locus-tag class description HV036_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HV036_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HV036_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV036_RS00035 ENOG4105CC0 LysR family Transcriptional regulator HV036_RS00045 ENOG410667J hydrolase HV036_RS00050 ENOG4105EMF GntR family transcriptional regulator HV036_RS00055 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HV036_RS00060 ENOG4108RTU Aldolase HV036_RS00065 ENOG4105CXK mandelate racemase muconate lactonizing HV036_RS00070 ENOG4105DJB Major Facilitator Superfamily HV036_RS00075 ENOG4105D99 atp gtp-binding protein HV036_RS00080 ENOG4105R2A (LipO)protein HV036_RS00090 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HV036_RS00095 ENOG4105D0C transport protein HV036_RS00100 ENOG4105FDP GntR family transcriptional regulator HV036_RS00105 ENOG4105CI1 PTS System HV036_RS00110 ENOG4105F8D glycoside hydrolase family 4 HV036_RS00115 ENOG4105VG5 Membrane HV036_RS00120 ENOG4105JP4 Inner membrane protein yidG HV036_RS00125 ENOG4105BZC d-serine deaminase HV036_RS00135 ENOG4105E5M Multidrug resistance protein D HV036_RS00155 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase HV036_RS00160 ENOG4108Z3N Transcriptional regulator HV036_RS00170 ENOG4105C7K acetolactate synthase HV036_RS00175 ENOG4105M71 acetolactate synthase 1 regulatory subunit HV036_RS00180 ENOG4108KX4 response regulator HV036_RS00185 ENOG4105BZU Histidine kinase HV036_RS00190 ENOG4105CXY transporter HV036_RS00195 ENOG4105CXY transporter HV036_RS00200 ENOG4105CPT Alpha beta hydrolase HV036_RS00205 ENOG4108SAJ Protein of unknown function (DUF1198) HV036_RS00215 ENOG4108UZ3 Transporter HV036_RS00220 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HV036_RS00225 ENOG4105VCP PTS System HV036_RS00230 ENOG4105CS2 ec 3.2.1.21 HV036_RS00235 ENOG4105CK1 PTS System HV036_RS00245 ENOG4105ETE Transcriptional regulator (LacI family HV036_RS00255 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HV036_RS00260 ENOG4105BZS acriflavin resistance protein HV036_RS00265 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV036_RS00270 ENOG41067SE Tetr family transcriptional regulator HV036_RS00275 ENOG4105VEV -acetyltransferase HV036_RS00280 ENOG4107XI7 Tetr family transcriptional regulator HV036_RS00290 ENOG4105D01 (LipO)protein HV036_RS00315 ENOG4105CW0 outer membrane usher protein HV036_RS00320 ENOG4108MQF Chaperone HV036_RS00350 ENOG4108N3D putative enzyme HV036_RS00375 ENOG4108JJA ABC, transporter HV036_RS00385 ENOG4108MBX Secretion Protein HV036_RS00390 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HV036_RS00395 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HV036_RS00400 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HV036_RS00405 ENOG4107SEY Conserved Protein HV036_RS00410 ENOG4105VT2 5-hydroxyisourate hydrolase HV036_RS00415 ENOG4108XDN Transcriptional regulator HV036_RS00435 ENOG4105CW0 outer membrane usher protein HV036_RS00440 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HV036_RS00445 ENOG4108RQP Major type 1 subunit fimbrin HV036_RS00465 ENOG4105ECQ AraC Family Transcriptional Regulator HV036_RS00495 ENOG4105CT4 transporter HV036_RS00500 ENOG4105CJQ hydrolase, family 31 HV036_RS00505 ENOG4105JV1 AsmA family HV036_RS00510 ENOG4105C2W permease HV036_RS00515 ENOG4105D6U Sodium Glutamate Symporter HV036_RS00520 ENOG4105CB5 ATP-dependent DNA helicase recG HV036_RS00525 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HV036_RS00530 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV036_RS00545 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HV036_RS00550 ENOG4105EN6 Membrane HV036_RS00555 ENOG4105DSJ YicC domain protein HV036_RS00560 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HV036_RS00565 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HV036_RS00575 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HV036_RS00580 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HV036_RS00585 ENOG4105W5Q DNA repair protein (RadC HV036_RS00590 ENOG4105KDC 50s ribosomal protein l28 HV036_RS00595 ENOG4105W0E 50S ribosomal protein L33 HV036_RS00600 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HV036_RS00605 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HV036_RS00610 ENOG4106WTF Glycosyl transferase, family 2 HV036_RS00615 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HV036_RS00620 ENOG4105K64 Glycosyl transferase, family 2 HV036_RS00625 ENOG4105CPK Glycosyl transferase (Group 1 HV036_RS00635 ENOG4105DKP glycosyl transferase, family 9 HV036_RS00660 ENOG4105D16 lipopolysaccharide heptosyltransferase i HV036_RS00665 ENOG4105XA0 heptosyltransferase ii HV036_RS00670 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HV036_RS00675 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV036_RS00680 ENOG4105CPQ Dehydrogenase HV036_RS00695 ENOG4106WTF Glycosyl transferase, family 2 HV036_RS00700 ENOG4105PXI polysaccharide deacetylase HV036_RS00705 ENOG41063SB peptidase HV036_RS00710 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HV036_RS00715 ENOG4107YZP Rhodanese domain protein HV036_RS00720 ENOG4105VW4 glutaredoxin 3 HV036_RS00725 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HV036_RS00730 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HV036_RS00735 ENOG4105D7W serine acetyltransferase HV036_RS00740 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HV036_RS00745 ENOG4105C4R Atp-dependent dna helicase HV036_RS00750 ENOG4105C9X ppx gppa phosphatase HV036_RS00765 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HV036_RS00770 ENOG4105ESV Glycosyl transferase, family 4 HV036_RS00775 ENOG4105SFE lipopolysaccharide biosynthesis protein HV036_RS00780 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HV036_RS00785 ENOG4107QQG Dehydrogenase HV036_RS00790 ENOG4108WJ1 acetyltransferase HV036_RS00795 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HV036_RS00800 ENOG4105EGZ biosynthesis protein HV036_RS00805 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HV036_RS00810 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HV036_RS00815 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HV036_RS00820 ENOG4105C85 amino acid HV036_RS00845 ENOG410601J HemY protein HV036_RS00850 ENOG4105ECF c-methyltransferase HV036_RS00855 ENOG41076E6 Uroporphyrinogen-III Synthase HV036_RS00860 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HV036_RS00865 ENOG4107T0K Adenylate cyclase HV036_RS00875 ENOG4105S7Z (LipO)protein HV036_RS00885 ENOG4105CT0 Protein of unknown function, DUF484 HV036_RS00890 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV036_RS00895 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HV036_RS00900 ENOG4105C4R Atp-dependent dna helicase HV036_RS00905 ENOG4107QUT magnesium and cobalt transport protein CorA HV036_RS00910 ENOG4105FR1 rard protein HV036_RS00915 ENOG4108VUY thioesterase Superfamily protein HV036_RS00920 ENOG4105HDD phospholipase HV036_RS00925 ENOG4105C9U ATP-dependent DNA helicase RecQ HV036_RS00930 ENOG4105CCF Lysine exporter protein (Lyse ygga) HV036_RS00935 ENOG410829K Lysine exporter protein (Lyse ygga) HV036_RS00940 ENOG4108EUD Lysophospholipase HV036_RS00945 ENOG4105DQF Hydrolase HV036_RS00950 ENOG4105EMK carboxylate amino acid amine transporter HV036_RS00955 ENOG4105DZ2 Transcriptional regulator HV036_RS00965 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HV036_RS00970 ENOG4107SXA Phosphorylase HV036_RS00975 ENOG4105CGY Dna recombination protein HV036_RS00980 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HV036_RS00985 ENOG4105JC1 sterol-binding domain protein HV036_RS00990 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HV036_RS00995 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HV036_RS01000 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HV036_RS01005 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HV036_RS01010 ENOG4105F8V Hydrolase, tatD family HV036_RS01015 ENOG4105MDZ Transcriptional activator rfaH HV036_RS01020 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV036_RS01025 ENOG4107QK7 reductase HV036_RS01030 ENOG4105C5H ABC transporter HV036_RS01035 ENOG4105MVF Transcriptional regulator HV036_RS01040 ENOG4106JH6 (LipO)protein HV036_RS01050 ENOG4105C5I Dehydrogenase HV036_RS01060 ENOG4105D7K pfkb domain protein HV036_RS01070 ENOG4108M60 Transcriptional regulator HV036_RS01075 ENOG4108ZG0 Ompa motb domain protein HV036_RS01080 ENOG4107QY8 reductase HV036_RS01085 ENOG4105HNP -acetyltransferase HV036_RS01090 ENOG4108R3E Dna-3-methyladenine glycosylase i HV036_RS01095 ENOG4105EAX Putative lipase HV036_RS01100 ENOG4105FCD Major Facilitator HV036_RS01105 ENOG4105DIJ Phosphoethanolamine transferase HV036_RS01115 ENOG4105DEF Extracellular solute-binding protein, family 5 HV036_RS01120 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV036_RS01125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV036_RS01130 ENOG4105C3U ABC transporter HV036_RS01135 ENOG4108JQ7 (ABC) transporter HV036_RS01140 ENOG4105CS9 pantothenic acid kinase HV036_RS01165 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HV036_RS01170 ENOG4105PM1 preprotein translocase subunit SecE HV036_RS01175 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HV036_RS01190 ENOG4108VZM 50s ribosomal protein L10 HV036_RS01200 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV036_RS01205 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV036_RS01220 ENOG4106TD9 Diguanylate cyclase HV036_RS01225 ENOG4105D41 biosynthesis protein thiH HV036_RS01230 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HV036_RS01235 ENOG4105WHD thiamine biosynthesis protein ThiS HV036_RS01240 ENOG4105D06 uba thif-type nad fad binding protein HV036_RS01245 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HV036_RS01250 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HV036_RS01255 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HV036_RS01265 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HV036_RS01270 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HV036_RS01275 ENOG4105R2J Conserved Protein HV036_RS01280 ENOG4105K70 DNA-binding protein HV036_RS01285 ENOG4108T8B Protein of unknown function (DUF1481) HV036_RS01290 ENOG4105C12 Phosphoribosylglycinamide synthetase HV036_RS01295 ENOG4105DC1 bifunctional purine biosynthesis protein purh HV036_RS01315 ENOG4105CVG Homoserine O-transsuccinylase HV036_RS01320 ENOG4107QP3 malate synthase g HV036_RS01325 ENOG4108I9X Isocitrate lyase HV036_RS01330 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HV036_RS01335 ENOG41069M3 Transcriptional regulator HV036_RS01340 ENOG4105C3R Methionine synthase HV036_RS01345 ENOG4105EAM Na Pi-cotransporter HV036_RS01360 ENOG4105FE9 pseudouridine synthase HV036_RS01365 ENOG4108ZR5 Conserved Protein HV036_RS01370 ENOG4105C09 Bile acid HV036_RS01375 ENOG4105CFH Aspartokinase HV036_RS01390 ENOG4108MDC (LipO)protein HV036_RS01395 ENOG4108Q9C Periplasmic Protein HV036_RS01400 ENOG4105E3R (LipO)protein HV036_RS01405 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HV036_RS01410 ENOG4105EG2 ABC transporter, permease HV036_RS01415 ENOG4105D56 permease protein HV036_RS01420 ENOG4107FKK extracellular solute-binding protein family 1 HV036_RS01425 ENOG4108IJ9 (ABC) transporter HV036_RS01435 ENOG4107W52 maltose operon periplasmic protein HV036_RS01440 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HV036_RS01445 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HV036_RS01450 ENOG4105E55 glycerol-3-phosphate acyltransferase HV036_RS01455 ENOG41080IJ Diacylglycerol kinase HV036_RS01460 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HV036_RS01465 ENOG4107R73 Mate efflux family protein HV036_RS01470 ENOG4105VDW Csbd family HV036_RS01475 ENOG4105MYN Zinc uptake regulation protein HV036_RS01490 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV036_RS01495 ENOG4105P4Z Phage shock protein G HV036_RS01500 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HV036_RS01505 ENOG4105CDU Replicative dna helicase HV036_RS01510 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV036_RS01515 ENOG4105CGF Aromatic amino acid aminotransferase HV036_RS01520 ENOG4105F0S class B acid phosphatase HV036_RS01525 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HV036_RS01530 ENOG4105MSB protein, conserved in bacteria HV036_RS01535 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HV036_RS01540 ENOG4108UUM single-stranded DNA-binding protein HV036_RS01545 ENOG4108FPN Integrase HV036_RS01570 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HV036_RS01590 ENOG4105CVR type I restriction-modification system HV036_RS01600 ENOG4105PMV Membrane HV036_RS01610 ENOG4108M8H domain protein HV036_RS01615 ENOG4108W3Q Transcriptional regulator HV036_RS01620 ENOG4108Z4X TRANSCRIPTIONal HV036_RS01625 ENOG4108K3A Glutathione S-transferase HV036_RS01630 ENOG4105C7N Xanthine uracil vitamin C permease HV036_RS01635 ENOG4105EEQ Na H antiporter HV036_RS01640 ENOG4105CMU LysR family (Transcriptional regulator HV036_RS01645 ENOG4105VAW lrga family HV036_RS01650 ENOG41067MG lrgb family HV036_RS01655 ENOG4107QN1 sodium solute HV036_RS01660 ENOG41062QD Membrane HV036_RS01665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV036_RS01670 ENOG4105CK2 sodium dicarboxylate symporter HV036_RS01675 ENOG4108KQ5 Integrase catalytic subunit HV036_RS01680 ENOG41082ND Uncharacterized protein yjcO HV036_RS01685 ENOG41074AV Hok/gef family HV036_RS01710 ENOG4105D2N Aldolase HV036_RS01720 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV036_RS01725 ENOG4105CNN ABC, transporter HV036_RS01730 ENOG4105C2J ABC transporter HV036_RS01735 ENOG4105BZU Histidine kinase HV036_RS01745 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HV036_RS01750 ENOG410849A acetyltransferase, (GNAT) family HV036_RS01755 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HV036_RS01760 ENOG4105FD8 phosphonate metabolism protein PhnM HV036_RS01765 ENOG4105HRV phosphonate c-p lyase system protein phnl HV036_RS01770 ENOG4105ENV phosphonate C-P lyase system protein PhnK HV036_RS01775 ENOG4105FT8 Phosphonate metabolism HV036_RS01780 ENOG4105EKV Phosphonate metabolism protein HV036_RS01785 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HV036_RS01790 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HV036_RS01795 ENOG4107RJJ Transcriptional regulator HV036_RS01805 ENOG4105EHI Phosphonate ABC transporter, periplasmic HV036_RS01810 ENOG4105D5T phosphonate abc transporter HV036_RS01815 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HV036_RS01820 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HV036_RS01825 ENOG4108F5E vimentin HV036_RS01830 ENOG4108YIV HV036_RS01835 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HV036_RS01840 ENOG4105CSH Transporter HV036_RS01845 ENOG4105D7X high-affinity nickel-transporter HV036_RS01910 ENOG4108KZE transcriptional regulator HV036_RS01915 ENOG4108QDQ Ubiquinol-cytochrome C chaperone HV036_RS01950 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV036_RS01990 ENOG4108SIC Transcriptional regulator HV036_RS01995 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HV036_RS02005 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV036_RS02010 ENOG4108IJ0 Aspartate ammonia-lyase HV036_RS02015 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HV036_RS02020 ENOG4105DVH amino acid HV036_RS02035 ENOG4108P2H Inner membrane protein YjiG HV036_RS02040 ENOG41074DU domain protein HV036_RS02045 ENOG4108ZVF (LipO)protein HV036_RS02050 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HV036_RS02055 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HV036_RS02065 ENOG4106BSU Entericidin B HV036_RS02085 ENOG4106FGB Beta-lactamase HV036_RS02090 ENOG4105ETT transcriptional Regulator, LysR family HV036_RS02100 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HV036_RS02105 ENOG4105E33 succinate dehydrogenase HV036_RS02110 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV036_RS02115 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HV036_RS02120 ENOG4107SC7 Inner membrane transporter yjeM HV036_RS02125 ENOG4105EGS Mechanosensitive ion channel HV036_RS02160 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HV036_RS02165 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HV036_RS02170 ENOG4105K8N protein family UPF0079, ATPase HV036_RS02175 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV036_RS02180 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HV036_RS02185 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HV036_RS02190 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HV036_RS02195 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HV036_RS02200 ENOG4107QJR hflk protein HV036_RS02205 ENOG4105EPW hflc protein HV036_RS02220 ENOG4105KPV Transcriptional regulator HV036_RS02225 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HV036_RS02230 ENOG4105C2N RNA methyltransferase TrmH family group 3 HV036_RS02235 ENOG4105CSH Transporter HV036_RS02240 ENOG4105CSU acyl-Coa dehydrogenase HV036_RS02245 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS02250 ENOG4105S17 UPF0379 protein yjfN HV036_RS02255 ENOG4105WSB biofilm stress and motility protein A HV036_RS02260 ENOG4108MXZ Esterase HV036_RS02275 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HV036_RS02305 ENOG4105KIT UPF0379 protein yjfY HV036_RS02310 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HV036_RS02315 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HV036_RS02320 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HV036_RS02325 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HV036_RS02330 ENOG4108IPJ Membrane HV036_RS02335 ENOG4105FHY Opacity-associated protein A HV036_RS02340 ENOG4108V1T peptidylprolyl cis-trans isomerase HV036_RS02350 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HV036_RS02355 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS02360 ENOG4105DXC membrane HV036_RS02370 ENOG4105BZU Histidine kinase HV036_RS02375 ENOG4108WQH regulatoR HV036_RS02395 ENOG4105ECR NmrA family HV036_RS02400 ENOG4105KVH Transcriptional regulator HV036_RS02405 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HV036_RS02410 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HV036_RS02415 ENOG4108UUE Transcriptional regulator HV036_RS02420 ENOG41061GZ Protein of unknown function (DUF1107) HV036_RS02425 ENOG4105C37 (CBS) domain HV036_RS02430 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HV036_RS02435 ENOG4105CFU surface antigen HV036_RS02440 ENOG4105MA0 exported protein HV036_RS02445 ENOG4108ZHD aig2 family HV036_RS02450 ENOG4105F0N pyrophosphate phospho-hydrolase HV036_RS02455 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HV036_RS02460 ENOG4105C2J ABC transporter HV036_RS02465 ENOG4107R9N ABC transporter HV036_RS02470 ENOG41062B0 ABC transporter, permease HV036_RS02475 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS02485 ENOG4105DFU Cell wall formation (By similarity) HV036_RS02490 ENOG4105N42 UPF0307 protein HV036_RS02495 ENOG4105CMS peptidase U62, modulator of DNA gyrase HV036_RS02500 ENOG4108XVM Cytochrome b(562) HV036_RS02530 ENOG41069H0 dihydroorotase EC 3.5.2.3 HV036_RS02550 ENOG4105EMD TRANSCRIPTIONal HV036_RS02555 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HV036_RS02560 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HV036_RS02565 ENOG4105CG3 alpha amylase, catalytic region HV036_RS02570 ENOG4105C5Y PTS System HV036_RS02590 ENOG4105D4X repressor HV036_RS02600 ENOG4105E2D ec 3.2.1.52 HV036_RS02605 ENOG4108M1A Chitin-binding protein HV036_RS02610 ENOG4105KME endoribonuclease L-psp HV036_RS02615 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HV036_RS02620 ENOG4105CXT aspartate transcarbamylase HV036_RS02625 ENOG41077AM PyrBI operon attenuator HV036_RS02635 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HV036_RS02640 ENOG4105CSX c4-dicarboxylate anaerobic carrier HV036_RS02645 ENOG4105DBV ornithine carbamoyltransferase HV036_RS02650 ENOG4105C5B carbamate kinase HV036_RS02660 ENOG4105F2I Transposase HV036_RS02665 ENOG4105XEP YhcH YjgK YiaL family protein HV036_RS02670 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV036_RS02675 ENOG4105C01 Dihydroxy-acid dehydratase HV036_RS02680 ENOG4105CT4 transporter HV036_RS02685 ENOG4105DSG hydrolase family 43 HV036_RS02690 ENOG4107HP6 Transcriptional regulator HV036_RS02695 ENOG4105DBV ornithine carbamoyltransferase HV036_RS02700 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HV036_RS02705 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HV036_RS02735 ENOG4105ZTC transcriptional activator, Ogr delta HV036_RS02800 ENOG4105ETE Transcriptional regulator (LacI family HV036_RS02810 ENOG4105CT4 transporter HV036_RS02835 ENOG4105CHJ isochorismatase hydrolase HV036_RS02855 ENOG4105BZU Histidine kinase HV036_RS02860 ENOG4108ZXC Two component transcriptional regulator, luxr family HV036_RS02865 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HV036_RS02870 ENOG4105EZE Cupin 4 family protein HV036_RS02895 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV036_RS02900 ENOG4106DIZ Domain of unknown function (DUF1127) HV036_RS02910 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV036_RS02925 ENOG4108ZHR arsR family transcriptional regulator HV036_RS02945 ENOG4106BRA Membrane HV036_RS02955 ENOG4106AXJ AraC family transcriptional regulator HV036_RS02960 ENOG4105C26 Dehydrogenase HV036_RS02980 ENOG4105CKI cobalamin synthesis protein HV036_RS02985 ENOG4105VCD cytoplasmic protein HV036_RS02990 ENOG4105D22 carbon starvation protein HV036_RS02995 ENOG4105YW5 deoR family transcriptional regulator HV036_RS03000 ENOG4107UWN reductase HV036_RS03005 ENOG4105EFA 4-hydroxyphenylacetate HV036_RS03020 ENOG4105CNV Aldolase HV036_RS03035 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HV036_RS03040 ENOG4105C26 Dehydrogenase HV036_RS03045 ENOG4105ERH Fumarylacetoacetate hydrolase HV036_RS03050 ENOG4108V8F Transcriptional regulator, MarR family HV036_RS03055 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS03060 ENOG4105XYF acetyltransferase HV036_RS03070 ENOG4105RI1 glycoprotein receptor HV036_RS03075 ENOG4106CVF DNA replication protein HV036_RS03080 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HV036_RS03085 ENOG4108ZHJ Organic hydroperoxide resistance protein HV036_RS03090 ENOG4105K56 Transcriptional regulator HV036_RS03095 ENOG4107XM3 UPF0442 protein HV036_RS03100 ENOG4105DWK Membrane HV036_RS03105 ENOG4108N8T regulatoR HV036_RS03110 ENOG4108T94 DNA-binding transcriptional activator BglJ HV036_RS03115 ENOG4108UIN ybak prolyl-trna synthetase associated region HV036_RS03120 ENOG4105CK1 PTS System HV036_RS03125 ENOG4108819 ferric iron reductase HV036_RS03130 ENOG4106TD9 Diguanylate cyclase HV036_RS03135 ENOG4105YBH Protein of unknown function (DUF1435) HV036_RS03155 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV036_RS03160 ENOG4108WPU DNA polymerase III subunit psi HV036_RS03165 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HV036_RS03170 ENOG4105PAD Hydrolase HV036_RS03175 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HV036_RS03180 ENOG4105K3G Periplasmic Protein HV036_RS03190 ENOG4108NRW Phospholipase, patatin family HV036_RS03195 ENOG4105EYA deoxyribonuclease HV036_RS03200 ENOG41076CZ activating enzyme HV036_RS03205 ENOG4105G0K glycine radical enzyme YjjI family HV036_RS03215 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HV036_RS03225 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HV036_RS03230 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HV036_RS03235 ENOG41062Z9 Membrane HV036_RS03240 ENOG4105EAC phosphoserine phosphatase HV036_RS03245 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HV036_RS03250 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HV036_RS03265 ENOG4105C5H ABC transporter HV036_RS03270 ENOG4107SC1 transglycosylase HV036_RS03275 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HV036_RS03280 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HV036_RS03285 ENOG4105CVJ phosphoglycerate mutase HV036_RS03290 ENOG4105UEI Transcriptional Regulator AraC Family HV036_RS03295 ENOG4108RH0 Crea protein HV036_RS03300 ENOG41065U4 response regulator HV036_RS03305 ENOG410759A HV036_RS03310 ENOG4106FVC RNA methyltransferase HV036_RS03320 ENOG4105CFH Aspartokinase HV036_RS03330 ENOG4105D98 threonine synthase HV036_RS03335 ENOG41062C6 Protein of unknown function (DUF2502) HV036_RS03340 ENOG4105D1Q UPF0246 protein HV036_RS03345 ENOG4105BZG amino acid carrier protein HV036_RS03350 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV036_RS03355 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV036_RS03360 ENOG4105CSH Transporter HV036_RS03365 ENOG4106HK8 GPR1 FUN34 yaaH family protein HV036_RS03370 ENOG4105CFG Acts as a chaperone (By similarity) HV036_RS03380 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HV036_RS03385 ENOG41063Z6 transcriptional regulator, lysR family HV036_RS03390 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HV036_RS03395 ENOG4105DTN riboflavin biosynthesis protein ribF HV036_RS03400 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HV036_RS03410 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HV036_RS03415 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HV036_RS03425 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HV036_RS03430 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HV036_RS03435 ENOG4105M5B (LipO)protein HV036_RS03445 ENOG4105EQR Transposase IS116 IS110 IS902 HV036_RS03455 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HV036_RS03460 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV036_RS03465 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HV036_RS03470 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HV036_RS03475 ENOG4105NWN ApaG protein HV036_RS03480 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HV036_RS03485 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HV036_RS03490 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HV036_RS03495 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HV036_RS03500 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HV036_RS03505 ENOG4105D3G Pseudouridine synthase HV036_RS03510 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HV036_RS03515 ENOG4105CQ2 DNA polymerase HV036_RS03520 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV036_RS03525 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HV036_RS03530 ENOG4105EF1 ribulokinase HV036_RS03540 ENOG4108KF1 Membrane HV036_RS03550 ENOG4106SMU thiamine transporter membrane protein HV036_RS03570 ENOG4105S8Q sugar efflux transporter HV036_RS03575 ENOG41060TC Hok gef cell toxic protein HV036_RS03580 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HV036_RS03585 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HV036_RS03590 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HV036_RS03595 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HV036_RS03605 ENOG41064T2 transcriptional regulator, lysR family HV036_RS03610 ENOG4105C7K acetolactate synthase HV036_RS03615 ENOG4108ZP8 Acetolactate synthase small subunit HV036_RS03620 ENOG4107B7Y DNA-binding transcriptional regulator FruR HV036_RS03625 ENOG4108V6E Cell division protein mraZ HV036_RS03635 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV036_RS03640 ENOG4105CJN penicillin-binding protein HV036_RS03645 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HV036_RS03650 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HV036_RS03655 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HV036_RS03665 ENOG4105CNI cell division protein FtsW HV036_RS03670 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HV036_RS03675 ENOG4105DFU Cell wall formation (By similarity) HV036_RS03680 ENOG4105CPF Cell wall formation (By similarity) HV036_RS03685 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HV036_RS03690 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HV036_RS03695 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HV036_RS03700 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV036_RS03705 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HV036_RS03710 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HV036_RS03715 ENOG4105M6F mutator MutT protein HV036_RS03720 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HV036_RS03725 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HV036_RS03730 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HV036_RS03735 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV036_RS03740 ENOG4105D7Q type ii secretion system HV036_RS03745 ENOG4107QHF type ii secretion system protein e HV036_RS03750 ENOG4108ZUW Major pilin subunit HV036_RS03755 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HV036_RS03760 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV036_RS03765 ENOG4106A72 regulatory protein AmpE HV036_RS03770 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HV036_RS03775 ENOG4105CT4 transporter HV036_RS03780 ENOG4105C85 amino acid HV036_RS03785 ENOG41073TP transcriptional regulator HV036_RS03790 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HV036_RS03795 ENOG4107QSN dihydrolipoamide acetyltransferase HV036_RS03800 ENOG4107QN2 dihydrolipoyl dehydrogenase HV036_RS03810 ENOG4108NST exported protein HV036_RS03815 ENOG4107QIJ Aconitate hydratase 2 HV036_RS03825 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HV036_RS03830 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HV036_RS03835 ENOG4108ZRK uncharacterized protein yacC HV036_RS03840 ENOG4105E3B Multicopper oxidase HV036_RS03845 ENOG4105DZG Dehydrogenase HV036_RS03850 ENOG4108UGV hypoxanthine phosphoribosyltransferase HV036_RS03855 ENOG41077A9 carbonic anhydrase HV036_RS03860 ENOG4105DA5 (ABC) transporter HV036_RS03865 ENOG4105E3A (ABC) transporter HV036_RS03870 ENOG4108YTN IIa component HV036_RS03875 ENOG4107BJW polysaccharide deacetylase HV036_RS03885 ENOG4105SN2 fimbrial-like adhesin protein HV036_RS03895 ENOG4108XEY fimbrial-like adhesin protein HV036_RS03900 ENOG4105CW0 outer membrane usher protein HV036_RS03905 ENOG4108VEV chaperone HV036_RS03915 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HV036_RS03920 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HV036_RS03925 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HV036_RS03930 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HV036_RS03935 ENOG4105DJ0 Poly(A) Polymerase HV036_RS03940 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HV036_RS03945 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HV036_RS03950 ENOG4105PW4 Sugar fermentation stimulation protein homolog HV036_RS03955 ENOG4107XID 2'-5' rna ligase HV036_RS03960 ENOG4105CQ7 ATP-dependent helicase HV036_RS03965 ENOG4105BZ4 penicillin-binding protein HV036_RS03970 ENOG4105E0K tonB-dependent siderophore receptor HV036_RS03975 ENOG4105E0A ABC, transporter HV036_RS03980 ENOG4105J76 Periplasmic binding protein HV036_RS03985 ENOG4105S6R Iron-hydroxamate transporter permease subunit HV036_RS03990 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HV036_RS03995 ENOG4105CMQ Chloride channel HV036_RS04000 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HV036_RS04005 ENOG4105EN6 Membrane HV036_RS04015 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HV036_RS04020 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HV036_RS04025 ENOG4105C0H protease HV036_RS04030 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HV036_RS04035 ENOG4108T8E UPF0325 protein HV036_RS04040 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HV036_RS04045 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HV036_RS04050 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HV036_RS04055 ENOG4105CE9 30S ribosomal protein S2 HV036_RS04060 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HV036_RS04065 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HV036_RS04075 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HV036_RS04085 ENOG4105KNE Phosphatidate cytidylyltransferase HV036_RS04090 ENOG4105DZP Membrane-associated zinc metalloprotease HV036_RS04095 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV036_RS04100 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HV036_RS04105 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV036_RS04110 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HV036_RS04115 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV036_RS04120 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV036_RS04125 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV036_RS04130 ENOG4105C0B DNA polymerase III (alpha subunit) HV036_RS04135 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HV036_RS04140 ENOG4105CXN decarboxylase HV036_RS04145 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HV036_RS04150 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HV036_RS04155 ENOG4105M1T rho-binding antiterminator HV036_RS04160 ENOG4105W1I UPF0253 protein HV036_RS04165 ENOG4108VWS Yaeq family HV036_RS04170 ENOG4108YZN class I peptide chain release factor HV036_RS04175 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HV036_RS04180 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HV036_RS04185 ENOG4108R96 Methyltransferase, YaeB family HV036_RS04190 ENOG4108R8X outer membrane lipoprotein HV036_RS04195 ENOG4105D01 (LipO)protein HV036_RS04200 ENOG4108UMI ABC transporter, permease HV036_RS04205 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HV036_RS04210 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HV036_RS04245 ENOG4105CV8 reductase HV036_RS04250 ENOG4105HEI LysR family (Transcriptional regulator HV036_RS04255 ENOG4105F27 Major Facilitator HV036_RS04260 ENOG4107NA1 Endonuclease Exonuclease phosphatase HV036_RS04265 ENOG4105F2W methyltransferase HV036_RS04270 ENOG4105E9H Lytic Murein transglycosylase HV036_RS04275 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HV036_RS04280 ENOG4105D1A Methyltransferase HV036_RS04290 ENOG4107RZZ dna polymerase iii epsilon subunit HV036_RS04305 ENOG4105C3U ABC transporter HV036_RS04310 ENOG4108JQ7 (ABC) transporter HV036_RS04325 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV036_RS04330 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HV036_RS04335 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV036_RS04340 ENOG4107QPN acyl-Coa dehydrogenase HV036_RS04350 ENOG4105E7A Glutamine amidotransferase HV036_RS04355 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HV036_RS04360 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV036_RS04370 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV036_RS04375 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV036_RS04380 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV036_RS04385 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HV036_RS04395 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV036_RS04400 ENOG4105CIN aminoacyl-histidine dipeptidase HV036_RS04405 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HV036_RS04410 ENOG4105V1F Fermentation respiration switch protein HV036_RS04420 ENOG4105FCK Membrane HV036_RS04425 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HV036_RS04430 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HV036_RS04440 ENOG4105DFP Integrase HV036_RS04505 ENOG4108XTP Transcriptional regulator HV036_RS04600 ENOG4105DDI hemolysin-type calcium-binding region HV036_RS04610 ENOG4105CKK Glycosyl transferase, family 2 HV036_RS04615 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HV036_RS04620 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HV036_RS04715 ENOG4105DTA methyltransferase HV036_RS04725 ENOG4105BZU Histidine kinase HV036_RS04745 ENOG4105F4G Membrane HV036_RS04750 ENOG4108IQI permease HV036_RS04755 ENOG4107QK5 Homocysteine s-methyltransferase HV036_RS04760 ENOG4106FTQ Taurine ABC transporter, periplasmic HV036_RS04765 ENOG4108ETV ABC transporter HV036_RS04770 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HV036_RS04775 ENOG4105E2B Taurine dioxygenase HV036_RS04785 ENOG4105D52 delta-aminolevulinic acid dehydratase HV036_RS04790 ENOG4108NSE outer membrane autotransporter barrel HV036_RS04795 ENOG4108PNB DNA-binding transcriptional regulator HV036_RS04800 ENOG4107R6D beta-lactam binding protein AmpH HV036_RS04805 ENOG4108RWI nicotinamidase HV036_RS04810 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HV036_RS04815 ENOG4107QS8 (LipO)protein HV036_RS04820 ENOG4105FR5 inner membrane protein YaiY HV036_RS04825 ENOG4105UNH Membrane HV036_RS04830 ENOG4105CPF Cell wall formation (By similarity) HV036_RS04845 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) HV036_RS04850 ENOG4105VIF phosphate starvation-inducible protein HV036_RS04855 ENOG4105BZU Histidine kinase HV036_RS04860 ENOG4105II7 pyrroline-5-carboxylate reductase HV036_RS04865 ENOG4108UPT UPF0178 protein HV036_RS04870 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV036_RS04875 ENOG4105SS3 HV036_RS04880 ENOG4105HBA AroM protein HV036_RS04885 ENOG4105NBK UPF0345 protein HV036_RS04895 ENOG4105DKQ ROK family HV036_RS04900 ENOG4105EYH Exonuclease HV036_RS04905 ENOG4107RH8 nuclease SbcCD subunit D HV036_RS04915 ENOG4105BZU Histidine kinase HV036_RS04920 ENOG4105CWM branched-chain amino acid transport system II carrier protein HV036_RS04925 ENOG4105C85 amino acid HV036_RS04930 ENOG4107R28 alpha amylase, catalytic region HV036_RS04945 ENOG4105D3R alkyl hydroperoxide reductase HV036_RS04950 ENOG4108ZYK Acyl carrier protein phosphodiesterase HV036_RS04960 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HV036_RS04965 ENOG4105VIE preprotein translocase, subunit YajC HV036_RS04970 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV036_RS04975 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV036_RS04985 ENOG4105DRB nucleoside-specific channel-forming protein HV036_RS04990 ENOG4108KIC (LipO)protein HV036_RS04995 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HV036_RS05000 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HV036_RS05005 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HV036_RS05010 ENOG4107YIM Involved in the transcription termination process (By similarity) HV036_RS05015 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HV036_RS05020 ENOG4105CPC Aldo Keto reductase HV036_RS05025 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HV036_RS05030 ENOG4105CTB Polyprenyl synthetase HV036_RS05035 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HV036_RS05040 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HV036_RS05045 ENOG4107S0N DJ-1 family HV036_RS05050 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HV036_RS05060 ENOG4107RDB Major Facilitator HV036_RS05065 ENOG4107W7X Aldolase HV036_RS05075 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV036_RS05085 ENOG4105CNN ABC, transporter HV036_RS05090 ENOG4105C2J ABC transporter HV036_RS05095 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HV036_RS05100 ENOG4105CMG Carbohydrate kinase HV036_RS05110 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HV036_RS05115 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HV036_RS05120 ENOG4105CCU oxidase (Subunit III) HV036_RS05125 ENOG4105BZ9 Cytochrome C oxidase, subunit I HV036_RS05130 ENOG4105E2S oxidase) subunit II HV036_RS05135 ENOG4105EYM Major Facilitator superfamily HV036_RS05140 ENOG4105IEY (LipO)protein HV036_RS05145 ENOG4105M85 Bola protein HV036_RS05150 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HV036_RS05165 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HV036_RS05170 ENOG4105K70 DNA-binding protein HV036_RS05175 ENOG4105EIN peptidylprolyl cis-trans isomerase HV036_RS05180 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HV036_RS05185 ENOG4108TGP Thioesterase superfamily protein HV036_RS05190 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HV036_RS05195 ENOG4108NFA extracellular solute-binding protein HV036_RS05200 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HV036_RS05210 ENOG4108XM1 transcriptional regulator AsnC family HV036_RS05215 ENOG4105BZ1 (ABC) transporter HV036_RS05220 ENOG4105BZ1 (ABC) transporter HV036_RS05225 ENOG4108YZA Nitrogen regulatory protein pii HV036_RS05230 ENOG4105BZU Histidine kinase HV036_RS05235 ENOG4105C29 acyl-CoA thioesterase HV036_RS05240 ENOG4108MNP Glycoprotein polysaccharide metabolism HV036_RS05245 ENOG41080UX Methyltransferase HV036_RS05265 ENOG4107U9B transcriptional regulator HV036_RS05270 ENOG4108VW9 Membrane HV036_RS05275 ENOG4105ETE Transcriptional regulator (LacI family HV036_RS05285 ENOG41066DG (EAL) domain protein HV036_RS05290 ENOG4105NRA 50s ribosomal protein l31 type b HV036_RS05295 ENOG4105YK5 50S ribosomal protein L36 HV036_RS05310 ENOG4105GSJ Inner membrane protein ylaC HV036_RS05315 ENOG4108UW5 maltose o-acetyltransferase HV036_RS05325 ENOG4108UKR Biofilm formation regulator YbaJ HV036_RS05330 ENOG4105BZS acriflavin resistance protein HV036_RS05335 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV036_RS05340 ENOG4107XI7 Tetr family transcriptional regulator HV036_RS05345 ENOG4105EGS Mechanosensitive ion channel HV036_RS05350 ENOG4106428 Protein of unknown function (DUF2496) HV036_RS05355 ENOG4108URS primosomal replication protein n'' HV036_RS05360 ENOG4105WD1 Membrane HV036_RS05365 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HV036_RS05370 ENOG4107QMP dna polymerase iii subunits gamma and tau HV036_RS05375 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HV036_RS05380 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HV036_RS05385 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HV036_RS05390 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HV036_RS05395 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HV036_RS05400 ENOG4107RE1 Inosine-guanosine kinase HV036_RS05405 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV036_RS05410 ENOG4105EU0 Major facilitator Superfamily HV036_RS05415 ENOG4105CGH 5'-nucleotidase HV036_RS05420 ENOG4108Z66 YbaK ebsC protein HV036_RS05425 ENOG4105MBR gumn family HV036_RS05430 ENOG4105C59 p-type ATPase HV036_RS05435 ENOG4108Z6Z Transcriptional regulator HV036_RS05440 ENOG4105G5H Membrane HV036_RS05445 ENOG4107QX8 SPFH domain, Band 7 family protein HV036_RS05455 ENOG41083J0 (ABC) transporter HV036_RS05460 ENOG4105C4B ABC transporter, permease HV036_RS05465 ENOG4107QR8 Thioredoxin HV036_RS05470 ENOG4105E1F short-chain dehydrogenase reductase HV036_RS05475 ENOG4108UJV acyl-CoA thioesterase i HV036_RS05480 ENOG4108I0Y (ABC) transporter HV036_RS05485 ENOG4105CV6 ABC transporter, permease HV036_RS05490 ENOG4105FCK Membrane HV036_RS05500 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HV036_RS05505 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HV036_RS05510 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HV036_RS05515 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV036_RS05520 ENOG4105C8N cysteinyl-tRNA synthetase HV036_RS05525 ENOG4105S2T inner membrane protein YbcI HV036_RS05530 ENOG4107P2S Transcriptional regulator HV036_RS05535 ENOG4105CI1 PTS System HV036_RS05540 ENOG4105WQ3 Rna-binding protein HV036_RS05545 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HV036_RS05550 ENOG4108WDE Fimbrial protein HV036_RS05555 ENOG4105NJT Fimbrial protein HV036_RS05560 ENOG4108AF8 Chaperone HV036_RS05565 ENOG4105CW0 outer membrane usher protein HV036_RS05570 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HV036_RS05575 ENOG4108ZI2 Fimbrial protein HV036_RS05580 ENOG4108Q9V regulatoR HV036_RS05615 ENOG4105TDT uncharacterized protein yahO HV036_RS05630 ENOG4105C85 amino acid HV036_RS05635 ENOG4105EAA nucleoside HV036_RS05655 ENOG4105CUY Mechanosensitive ion channel HV036_RS05675 ENOG4108RCM Nitroreductase HV036_RS05680 ENOG4105MSB protein, conserved in bacteria HV036_RS05685 ENOG41067SE Tetr family transcriptional regulator HV036_RS05695 ENOG4105SUT Transcriptional Regulator AraC Family HV036_RS05700 ENOG4105E0K tonB-dependent siderophore receptor HV036_RS05710 ENOG4105WQ6 Membrane HV036_RS05720 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV036_RS05730 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HV036_RS05745 ENOG4105CNA YD repeat protein HV036_RS05795 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HV036_RS05825 ENOG4105C7K acetolactate synthase HV036_RS05830 ENOG4105CHR reductase HV036_RS05860 ENOG4105C94 Transporter HV036_RS05880 ENOG4105DIK (ABC) transporter HV036_RS05885 ENOG4105CC5 ABC transporter HV036_RS05890 ENOG4105CC5 ABC transporter HV036_RS05895 ENOG4108TSE Transferase HV036_RS05900 ENOG4107RNH Outer membrane receptor FepA HV036_RS05905 ENOG4105E93 esterase HV036_RS05910 ENOG41085A6 mbth domain-containing protein HV036_RS05915 ENOG4105C0W non-ribosomal peptide synthetase HV036_RS05920 ENOG4105E0A ABC, transporter HV036_RS05925 ENOG4105TVJ transport system, permease HV036_RS05930 ENOG4105DQ5 transport system permease protein HV036_RS05935 ENOG4105E8G Major facilitator Superfamily HV036_RS05940 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HV036_RS05945 ENOG4105E4F Isochorismate synthase HV036_RS05950 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HV036_RS05955 ENOG4105WQI isochorismatase HV036_RS05960 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HV036_RS05965 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HV036_RS05970 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HV036_RS05975 ENOG4108P2H Inner membrane protein YjiG HV036_RS05980 ENOG41074DU domain protein HV036_RS05985 ENOG4105D22 carbon starvation protein HV036_RS05990 ENOG4105VCD cytoplasmic protein HV036_RS06005 ENOG4105CHR reductase HV036_RS06010 ENOG4107SCQ Iron-containing alcohol dehydrogenase HV036_RS06015 ENOG4105C2J ABC transporter HV036_RS06020 ENOG4105CNN ABC, transporter HV036_RS06035 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HV036_RS06040 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HV036_RS06050 ENOG4105HVQ Regulatory factor of maltose metabolism HV036_RS06060 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HV036_RS06065 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HV036_RS06070 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HV036_RS06075 ENOG4105CHM Aminotransferase HV036_RS06080 ENOG4105GTN ParB Domain Protein Nuclease HV036_RS06085 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HV036_RS06095 ENOG4105D3R alkyl hydroperoxide reductase HV036_RS06100 ENOG4108JU3 Alkyl hydroperoxide reductase HV036_RS06105 ENOG4108U51 Universal stress protein HV036_RS06110 ENOG4105E2A Dehydrogenase HV036_RS06115 ENOG4105NXH GreA GreB family elongation factor HV036_RS06125 ENOG4105KTS ribonuclease HV036_RS06130 ENOG4105CEE C4-dicarboxylate transporter HV036_RS06150 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HV036_RS06160 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HV036_RS06180 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HV036_RS06185 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HV036_RS06190 ENOG41064T2 transcriptional regulator, lysR family HV036_RS06195 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HV036_RS06200 ENOG4108Z43 UPF0250 protein HV036_RS06205 ENOG4105DZ1 carboxypeptidase HV036_RS06210 ENOG4105K6T rare lipoprotein A HV036_RS06215 ENOG4105CNI cell division protein FtsW HV036_RS06220 ENOG4105CJN penicillin-binding protein HV036_RS06225 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HV036_RS06230 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HV036_RS06240 ENOG4105DJF DNA polymerase III, delta' subunit HV036_RS06250 ENOG4105C8T Leucyl-tRNA synthetase HV036_RS06255 ENOG4107PAI alpha helical protein HV036_RS06260 ENOG4105DU0 nucleoside hydrolase HV036_RS06265 ENOG4105CDA abc transporter atp-binding protein HV036_RS06270 ENOG4105DRP amino acid AbC transporter HV036_RS06275 ENOG4105EAD ABC transporter HV036_RS06280 ENOG4107RP9 extracellular solute-binding protein, family 3 HV036_RS06285 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HV036_RS06290 ENOG4108JU5 Magnesium and cobalt efflux protein HV036_RS06295 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HV036_RS06300 ENOG4105C9A Phoh family HV036_RS06305 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HV036_RS06310 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV036_RS06350 ENOG4105CAQ asparagine synthetase HV036_RS06355 ENOG4105D4U had-superfamily hydrolase, subfamily iia HV036_RS06360 ENOG4105E2R ROK family HV036_RS06365 ENOG4105CE4 GlcNAc 6-P deacetylase HV036_RS06375 ENOG4105CI1 PTS System HV036_RS06380 ENOG4105CX6 glutaminyL-tRNA synthetase HV036_RS06390 ENOG4105GX6 (LipO)protein HV036_RS06395 ENOG41090R7 Ferric uptake HV036_RS06405 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HV036_RS06410 ENOG4105NNH LexA regulated protein HV036_RS06415 ENOG4105EV9 Alpha Beta Hydrolase HV036_RS06420 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HV036_RS06425 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HV036_RS06430 ENOG4105D5Q Arginine ornithine antiporter HV036_RS06435 ENOG4105CXN decarboxylase HV036_RS06445 ENOG4105EEX Two component transcriptional regulator (Winged helix family HV036_RS06450 ENOG4105C08 Histidine kinase HV036_RS06455 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HV036_RS06460 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HV036_RS06465 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HV036_RS06475 ENOG4105XIQ Protein of unknown function (DUF2517) HV036_RS06480 ENOG4105CVP deoxyribo-dipyrimidine photolyase HV036_RS06485 ENOG4107QNR UPF0135 protein HV036_RS06490 ENOG4105P4J Allophanate hydrolase, subunit 1 HV036_RS06495 ENOG4107R7A Allophanate hydrolase subunit 2 HV036_RS06500 ENOG4105E7W lamb ycsf family protein HV036_RS06505 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HV036_RS06510 ENOG4105BZN citrate synthase HV036_RS06515 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HV036_RS06520 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HV036_RS06525 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV036_RS06530 ENOG4105E33 succinate dehydrogenase HV036_RS06535 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HV036_RS06540 ENOG4105C7S Dehydrogenase HV036_RS06545 ENOG4105CMV Succinyl-CoA synthetase subunit beta HV036_RS06550 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HV036_RS06555 ENOG4105FDP GntR family transcriptional regulator HV036_RS06560 ENOG4105DM4 PTS System HV036_RS06565 ENOG4105C8I hydrolase, family 38 HV036_RS06570 ENOG4105C4M (Ubiquinol oxidase) subunit I HV036_RS06575 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV036_RS06585 ENOG4105KJB cyd operon protein YbgE HV036_RS06590 ENOG4107YD3 Thioesterase HV036_RS06595 ENOG4105E02 MotA TolQ exbB proton channel HV036_RS06605 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HV036_RS06610 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HV036_RS06615 ENOG4105KCK Peptidoglycan-associated lipoprotein HV036_RS06620 ENOG4105UFD tol-pal system protein YbgF HV036_RS06655 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HV036_RS06660 ENOG4105PGM cation diffusion facilitator family transporter HV036_RS06665 ENOG4105JND homeobox protein HV036_RS06670 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV036_RS06675 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HV036_RS06680 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HV036_RS06685 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HV036_RS06690 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HV036_RS06695 ENOG4105CMR udp-glucose 4-epimerase HV036_RS06700 ENOG4105DKW ABC transporter HV036_RS06705 ENOG4105F4R Transcriptional regulator mode HV036_RS06715 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HV036_RS06720 ENOG4105E0C molybdate abc transporter HV036_RS06730 ENOG4108K4B hydrolase HV036_RS06735 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HV036_RS06740 ENOG4105NBR Pectinesterase HV036_RS06745 ENOG4105CI2 imidazolone-5-propionate hydrolase HV036_RS06750 ENOG41088SP formiminoglutamate hydrolase HV036_RS06760 ENOG4105CGP Urocanate hydratase HV036_RS06765 ENOG4105C84 Histidine ammonia-lyase HV036_RS06770 ENOG4108V1U phospholipid-binding protein HV036_RS06775 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HV036_RS06780 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HV036_RS06785 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV036_RS06790 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV036_RS06810 ENOG4105CHW UPF0052 protein HV036_RS06820 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV036_RS06825 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HV036_RS06830 ENOG4105M00 molybdopterin converting factor, subunit 1 HV036_RS06835 ENOG4108ZAF Molybdopterin HV036_RS06840 ENOG4105HFZ Membrane HV036_RS06845 ENOG4107UXM Membrane HV036_RS06850 ENOG4105DZQ phospholipase D Transphosphatidylase HV036_RS06855 ENOG4105X23 Endonuclease Exonuclease phosphatase HV036_RS06860 ENOG4105I9U inner membrane protein ybhQ HV036_RS06865 ENOG4107QWP ABC-2 type transporter HV036_RS06870 ENOG4107QWP ABC-2 type transporter HV036_RS06875 ENOG4105CJ1 ABC, transporter HV036_RS06880 ENOG4105D0S secretion protein (HlyD HV036_RS06885 ENOG4107MVR Transcriptional regulator HV036_RS06890 ENOG4105C1J atp-dependent rna helicase HV036_RS06895 ENOG4105DVT helicase HV036_RS06910 ENOG4105CW0 outer membrane usher protein HV036_RS06915 ENOG4108VCD Chaperone HV036_RS06920 ENOG4105MX3 Fimbrial HV036_RS06925 ENOG4108MTB glycosyl transferase family HV036_RS06930 ENOG4105VR4 UPF0379 protein ybiJ HV036_RS06935 ENOG4105KSC Transcriptional regulator, TraR DksA family HV036_RS06940 ENOG4105ZY9 UPF0379 protein ybiM HV036_RS06945 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HV036_RS06950 ENOG4105D8X mechanosensitive ion channel HV036_RS06955 ENOG4105CDA abc transporter atp-binding protein HV036_RS06960 ENOG4105E5Q amino acid AbC transporter HV036_RS06965 ENOG4107R0W ABC transporter HV036_RS06970 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HV036_RS06980 ENOG4108T1M outer membrane protein x HV036_RS06985 ENOG4108I6E Sulfatase HV036_RS06995 ENOG4105KST dependent repressor HV036_RS07000 ENOG4105F4P )-transporter HV036_RS07005 ENOG4105CW7 secretion protein, HlyD family HV036_RS07010 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV036_RS07020 ENOG4105CPC Aldo Keto reductase HV036_RS07025 ENOG4105CS2 ec 3.2.1.21 HV036_RS07030 ENOG4105CK1 PTS System HV036_RS07035 ENOG4105FDP GntR family transcriptional regulator HV036_RS07040 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV036_RS07045 ENOG4105C5H ABC transporter HV036_RS07055 ENOG4105DPW Major facilitator superfamily MFS_1 HV036_RS07060 ENOG4105ETE Transcriptional regulator (LacI family HV036_RS07065 ENOG41072TH Protein of unknown function (DUF1479) HV036_RS07070 ENOG4108HCJ Hydrolase HV036_RS07080 ENOG4105F1A Pyruvate formate-lyase HV036_RS07085 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV036_RS07090 ENOG4105D06 uba thif-type nad fad binding protein HV036_RS07095 ENOG4105CVM Molybdenum cofactor synthesis domain protein HV036_RS07100 ENOG4105D44 asparaginase HV036_RS07105 ENOG4108JQ6 ABC transporter HV036_RS07125 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HV036_RS07130 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HV036_RS07135 ENOG4105D8V Glucose sorbosone dehydrogenase HV036_RS07140 ENOG4108TGY Glutathione S-transferase HV036_RS07145 ENOG4105DZ1 carboxypeptidase HV036_RS07150 ENOG4107FB0 transcriptional regulator DeoR family HV036_RS07155 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HV036_RS07165 ENOG4107QF7 multi-drug HV036_RS07170 ENOG4108HCJ Hydrolase HV036_RS07175 ENOG4106UW1 Major Facilitator superfamily HV036_RS07180 ENOG4108RFG Tetr family transcriptional regulator HV036_RS07195 ENOG4105KBH arsR family transcriptional regulator HV036_RS07230 ENOG4105GWF inner membrane protein YbjM HV036_RS07235 ENOG41090BQ Glutaredoxin HV036_RS07240 ENOG4108DBC nitroreductase HV036_RS07245 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HV036_RS07250 ENOG4108RMJ sensory transduction regulator HV036_RS07255 ENOG4107RUE extracellular solute-binding protein family 1 HV036_RS07260 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV036_RS07265 ENOG4105F38 ABC transporter, permease HV036_RS07270 ENOG4105D38 putrescine abc transporter HV036_RS07275 ENOG4105RBQ inner membrane protein ybjO HV036_RS07280 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HV036_RS07285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV036_RS07290 ENOG4105BZU Histidine kinase HV036_RS07295 ENOG4106TNF Periplasmic binding protein HV036_RS07300 ENOG4105DMR ABC, transporter HV036_RS07305 ENOG4105GBT ABC transporter HV036_RS07310 ENOG4106PMH Extracellular solute-binding protein family 3 HV036_RS07315 ENOG4105E5Z arginine transporter ATP-binding subunit HV036_RS07320 ENOG41064MM (LipO)protein HV036_RS07325 ENOG4105K8R UPF0145 protein HV036_RS07330 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV036_RS07335 ENOG4108PNB DNA-binding transcriptional regulator HV036_RS07350 ENOG4108XKW General secretion pathway protein C HV036_RS07355 ENOG4105GVR general secretion pathway protein D HV036_RS07360 ENOG4107QHF type ii secretion system protein e HV036_RS07365 ENOG4105D7Q type ii secretion system HV036_RS07370 ENOG4108VAU general secretion pathway protein G HV036_RS07380 ENOG4105X5Z General secretion pathway protein I HV036_RS07425 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HV036_RS07430 ENOG4105CGD Nad-dependent epimerase dehydratase HV036_RS07435 ENOG4105C5W Aldolase HV036_RS07440 ENOG4105C7K acetolactate synthase HV036_RS07445 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV036_RS07450 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HV036_RS07455 ENOG4105DWU Membrane HV036_RS07460 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV036_RS07465 ENOG4105CPB ATP-dependent endonuclease of the OLD family HV036_RS07470 ENOG4108MJ5 VirK protein HV036_RS07475 ENOG4105DJY efflux transporter, rnd family, mfp subunit HV036_RS07485 ENOG4105VEQ Cold shock protein HV036_RS07490 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HV036_RS07495 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV036_RS07510 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HV036_RS07515 ENOG4108JJ8 (ABC) transporter HV036_RS07520 ENOG4108JJ9 ABC, transporter HV036_RS07525 ENOG4105C3M thioredoxin reductase HV036_RS07530 ENOG4105EW9 transcriptional regulator AsnC family HV036_RS07535 ENOG4105CNU cell division protein FtsK HV036_RS07540 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HV036_RS07545 ENOG4105D1H recombination factor protein RarA HV036_RS07550 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HV036_RS07555 ENOG4107QY8 reductase HV036_RS07560 ENOG4105QAX Iron-sulfur HV036_RS07565 ENOG4107KGK dmso reductase anchor subunit HV036_RS07570 ENOG4108ISG Major Facilitator HV036_RS07580 ENOG4105F1A Pyruvate formate-lyase HV036_RS07585 ENOG4105C6N Formate acetyltransferase HV036_RS07590 ENOG4105TMB Formate nitrite transporter HV036_RS07595 ENOG4105DDY UPF0142 protein ycaO HV036_RS07600 ENOG4107VMU Membrane HV036_RS07605 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HV036_RS07610 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HV036_RS07615 ENOG4105CAT Cytidine monophosphate kinase HV036_RS07620 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HV036_RS07625 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV036_RS07630 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HV036_RS07635 ENOG4105BZ1 (ABC) transporter HV036_RS07640 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HV036_RS07645 ENOG4105T0Z Conserved Protein HV036_RS07650 ENOG4105W49 UPF0434 protein HV036_RS07655 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HV036_RS07660 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HV036_RS07665 ENOG4107S90 membrAne HV036_RS07670 ENOG4106371 Methyltransferase HV036_RS07675 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HV036_RS07680 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HV036_RS07685 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HV036_RS07690 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HV036_RS07695 ENOG4105EAQ (twin-arginine translocation) pathway signal HV036_RS07700 ENOG4105C5X domain protein HV036_RS07705 ENOG4105CGF Aromatic amino acid aminotransferase HV036_RS07715 ENOG4105C5S asparaginyl-tRNA synthetase HV036_RS07720 ENOG4107RH7 Nicotinate phosphoribosyltransferase HV036_RS07725 ENOG4105CD8 aminopeptidase N HV036_RS07735 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HV036_RS07740 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HV036_RS07745 ENOG4105GVF (ABC) transporter HV036_RS07750 ENOG4108UZX fmn reductase HV036_RS07755 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HV036_RS07760 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HV036_RS07765 ENOG4105QVC MOSC domain-containing protein HV036_RS07770 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HV036_RS07775 ENOG4105C5H ABC transporter HV036_RS07780 ENOG4105F1S paraquat-inducible protein a HV036_RS07785 ENOG4105DY2 Paraquat-inducible protein b HV036_RS07790 ENOG4108Q2G (LipO)protein HV036_RS07795 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HV036_RS07805 ENOG4105DAN ATP-dependent protease HV036_RS07810 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HV036_RS07815 ENOG4105UYK outer membrane protein a HV036_RS07820 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HV036_RS07825 ENOG4108RZ1 DNA transformation protein HV036_RS07830 ENOG4105EM2 membrane HV036_RS07835 ENOG410901E Membrane HV036_RS07840 ENOG41088T4 Helicase IV HV036_RS07845 ENOG4108Z5K methylglyoxal synthase HV036_RS07850 ENOG4108Q67 UPF0319 protein HV036_RS07855 ENOG4105K4P CoA-binding domain protein HV036_RS07860 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HV036_RS07865 ENOG4105DR4 Methyltransferase HV036_RS07870 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HV036_RS07880 ENOG4108MN8 Membrane HV036_RS07885 ENOG4107QSI ABC, transporter HV036_RS07900 ENOG4105EHG Permease protein HV036_RS07910 ENOG4105EGS Mechanosensitive ion channel HV036_RS07930 ENOG4105CJW magnesium transporter HV036_RS07935 ENOG4107T5V SNARE associated Golgi HV036_RS07940 ENOG4105D6F Phosphatase HV036_RS07945 ENOG4105XH3 HV036_RS07950 ENOG4105CS1 NAD(P)H quinone oxidoreductase HV036_RS07955 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HV036_RS07965 ENOG4105C2W permease HV036_RS07970 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HV036_RS07975 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HV036_RS07980 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HV036_RS07985 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HV036_RS07990 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HV036_RS07995 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HV036_RS08000 ENOG4108R86 Transcriptional regulator HV036_RS08010 ENOG4105C26 Dehydrogenase HV036_RS08015 ENOG4105CK7 Sodium proline symporter HV036_RS08025 ENOG4105D9N nucleoside HV036_RS08035 ENOG410650H (LipO)protein HV036_RS08040 ENOG4105DBE peroxidase HV036_RS08045 ENOG4105D5M phosphate starvation-inducible protein HV036_RS08050 ENOG4105BZG amino acid carrier protein HV036_RS08065 ENOG4105CHJ isochorismatase hydrolase HV036_RS08070 ENOG4105EUB pirin domain protein HV036_RS08095 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HV036_RS08100 ENOG4107SSZ Phosphatase HV036_RS08105 ENOG4107XHZ cytoplasmic chaperone TorD family protein HV036_RS08110 ENOG4108UQ5 membrane protein YcdZ HV036_RS08115 ENOG4105P8Q Curli production assembly transport component CsgG HV036_RS08120 ENOG4108WYR Curli production assembly transport component, CsgF HV036_RS08125 ENOG4108XDW curli assembly protein CsgE HV036_RS08130 ENOG41086KC Transcriptional regulator HV036_RS08135 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HV036_RS08140 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HV036_RS08145 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HV036_RS08150 ENOG41068SS HV036_RS08155 ENOG4108UVJ appr-1-p processing domain protein HV036_RS08170 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HV036_RS08175 ENOG4105NAC (LipO)protein HV036_RS08180 ENOG4108W47 Acidic protein msyB HV036_RS08190 ENOG4105D1S lipid A biosynthesis HV036_RS08195 ENOG4105C72 UPF0176 protein HV036_RS08200 ENOG4108YYC ycei family HV036_RS08205 ENOG4105DS1 cytochrome b561 HV036_RS08210 ENOG4106974 biofilm formation HV036_RS08215 ENOG4105F76 Sarcosine oxidase HV036_RS08220 ENOG4105PVA Biofilm formation regulatory protein BssS HV036_RS08225 ENOG4105MEA DNA damage-inducible protein i HV036_RS08230 ENOG4105EKE dihydroorotase HV036_RS08235 ENOG4105F3T (LipO)protein HV036_RS08240 ENOG4105EV4 Multidrug resistance protein mdtH HV036_RS08245 ENOG4105D9U N-acetyltransferase HV036_RS08250 ENOG4108YXG UPF0502 protein HV036_RS08255 ENOG4105EP9 oxidoreductase HV036_RS08260 ENOG4105CJR Integral membrane protein (MviN HV036_RS08265 ENOG4105QVD Flagella synthesis protein FlgN HV036_RS08270 ENOG4105M9M anti-sigma28 factor FlgM HV036_RS08275 ENOG4105CKS Flagella basal body P-ring formation protein flgA HV036_RS08280 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HV036_RS08285 ENOG4108ZC9 flagellar basal-body rod protein flgc HV036_RS08290 ENOG4105W00 Flagellar hook capping protein HV036_RS08295 ENOG4105BZE flagellar hook protein, FlgE HV036_RS08300 ENOG4108KPB Flagellar basal-body rod protein FlgF HV036_RS08305 ENOG4105CGA flagellar basal-body rod protein FlgG HV036_RS08320 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HV036_RS08325 ENOG4105E1Q flagellar hook-associated protein HV036_RS08330 ENOG4105DTJ flagellar hook-associated protein HV036_RS08335 ENOG4105EQ0 Major Facilitator superfamily HV036_RS08340 ENOG4105EJC lysr family transcriptional regulator HV036_RS08345 ENOG4107QQB Ribonuclease E HV036_RS08350 ENOG4105EI2 Pseudouridine synthase HV036_RS08355 ENOG4108UHJ MAF-like protein HV036_RS08360 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HV036_RS08365 ENOG4105VGS 50s ribosomal protein l32 HV036_RS08370 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HV036_RS08375 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HV036_RS08380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV036_RS08385 ENOG4105CHR reductase HV036_RS08390 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HV036_RS08395 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV036_RS08400 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HV036_RS08405 ENOG4105HHA aminodeoxychorismate lyase HV036_RS08415 ENOG4107QRG dna polymerase iii HV036_RS08420 ENOG4105F8V Hydrolase, tatD family HV036_RS08425 ENOG4105CI1 PTS System HV036_RS08430 ENOG4105CNM Receptor HV036_RS08435 ENOG4105K59 histidine triad (HIT) protein HV036_RS08440 ENOG41090DQ Lipoprotein HV036_RS08445 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HV036_RS08460 ENOG4105D0Y UPF0227 protein HV036_RS08465 ENOG4105CEP NADH dehydrogenase HV036_RS08470 ENOG4107MBR 17 kDa surface antigen HV036_RS08475 ENOG4108IND Tetr family transcriptional regulator HV036_RS08480 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HV036_RS08485 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV036_RS08490 ENOG4108JA2 transcriptioN-repair coupling factor HV036_RS08495 ENOG4105IQC Inner membrane protein YcfT HV036_RS08500 ENOG4105D60 lipoprotein releasing system transmembrane protein HV036_RS08505 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HV036_RS08510 ENOG4105D60 lipoprotein releasing system transmembrane protein HV036_RS08515 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HV036_RS08520 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HV036_RS08525 ENOG4108HM4 ABC transporter HV036_RS08530 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component HV036_RS08550 ENOG4108UK5 Transposase HV036_RS08555 ENOG4105EZE Cupin 4 family protein HV036_RS08560 ENOG4105IFJ Histidine kinase HV036_RS08565 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV036_RS08575 ENOG4107QTF adenylosuccinate lyase HV036_RS08580 ENOG41075W9 High frequency lysogenization protein HflD homolog HV036_RS08595 ENOG4108R99 pseudouridine synthase HV036_RS08600 ENOG4108HMX isocitrate dehydrogenase (NADP) HV036_RS08605 ENOG4105N0E Protein of unknown function (DUF2543) HV036_RS08620 ENOG4105Y3U Transglycosylase-associated protein HV036_RS08630 ENOG4106G4W HV036_RS08635 ENOG410620I Diguanylate cyclase HV036_RS08640 ENOG4105UCG Domain of unknown function (DUF333) HV036_RS08650 ENOG4105K78 MarR family Transcriptional regulator HV036_RS08655 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HV036_RS08660 ENOG4105DJ2 Major Facilitator Superfamily HV036_RS08665 ENOG4105R1U AraC Family Transcriptional Regulator HV036_RS08670 ENOG4108VMM UPF0756 membrane protein HV036_RS08680 ENOG4105CT4 transporter HV036_RS08685 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HV036_RS08690 ENOG4106AKX UPF0229 protein HV036_RS08695 ENOG4105CYN Serine protein kinase HV036_RS08700 ENOG4105GNX MltA-interacting MipA family protein HV036_RS08705 ENOG4105DSB aldose 1-epimerase HV036_RS08710 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV036_RS08720 ENOG4105VUT cytoplasmic protein HV036_RS08730 ENOG4108RWI nicotinamidase HV036_RS08735 ENOG4105HDK L-asparaginase HV036_RS08740 ENOG4105D07 Signal peptide peptidase, SppA HV036_RS08745 ENOG41069NU Nitroreductase HV036_RS08750 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HV036_RS08755 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV036_RS08760 ENOG4105D82 Glutamate dehydrogenase HV036_RS08765 ENOG4105MTM Protein of unknown function (DUF1496) HV036_RS08770 ENOG4105M6F mutator MutT protein HV036_RS08775 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV036_RS08780 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HV036_RS08785 ENOG4107RM6 sulfurtransferase HV036_RS08790 ENOG4108VGW abc transporter atp-binding protein HV036_RS08795 ENOG4105CXZ ABC transporter, permease HV036_RS08800 ENOG4105VNH ABC transporter solute-binding protein HV036_RS08810 ENOG4105CGK Exodeoxyribonuclease III HV036_RS08815 ENOG4105C8Y Acetylornithine aminotransferase HV036_RS08820 ENOG4105F4X arginine HV036_RS08825 ENOG4105C26 Dehydrogenase HV036_RS08830 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HV036_RS08840 ENOG4108SPG Periplasmic Protein HV036_RS08845 ENOG41090B9 response to stress HV036_RS08850 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HV036_RS08855 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HV036_RS08860 ENOG4105KKI DNA-binding transcriptional activator OsmE HV036_RS08865 ENOG4105VZJ PTS System HV036_RS08870 ENOG4105CK1 PTS System HV036_RS08875 ENOG4105VCP PTS System HV036_RS08880 ENOG4105EZV Transcriptional regulator HV036_RS08885 ENOG4105F8D glycoside hydrolase family 4 HV036_RS08890 ENOG410901P UPF0249 protein HV036_RS08895 ENOG4105CH6 catalase HV036_RS08905 ENOG4108ETY sodium dicarboxylate symporter HV036_RS08910 ENOG4107K5X Membrane-bound metal-dependent hydrolase HV036_RS08915 ENOG4105CHR reductase HV036_RS08920 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HV036_RS08925 ENOG4107PN8 YfeABCD locus regulator HV036_RS08935 ENOG4105P10 Uncharacterized protein ydiZ HV036_RS08940 ENOG4105DE4 1-phosphofructokinase HV036_RS08950 ENOG4108NE3 Salt-induced outer membrane protein HV036_RS08955 ENOG4105VR4 UPF0379 protein ybiJ HV036_RS08975 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HV036_RS08980 ENOG41082NX 50s ribosomal protein l35 HV036_RS08995 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HV036_RS09000 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HV036_RS09005 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV036_RS09015 ENOG4108V06 Glutathione peroxidase HV036_RS09020 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HV036_RS09025 ENOG4108QBX (LipO)protein HV036_RS09030 ENOG4108TC0 Diguanylate phosphodiesterase HV036_RS09035 ENOG4105CNG UPF0061 protein HV036_RS09040 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HV036_RS09045 ENOG4105EHG Permease protein HV036_RS09050 ENOG4107R4I Periplasmic binding protein HV036_RS09055 ENOG4106QJH hemin transport protein HV036_RS09060 ENOG4107ENK receptor HV036_RS09070 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV036_RS09075 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HV036_RS09080 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HV036_RS09085 ENOG4105CT4 transporter HV036_RS09105 ENOG4105IPI Membrane HV036_RS09110 ENOG4105CQB FAD linked oxidase domain protein HV036_RS09115 ENOG4105KA0 thioesterase Superfamily protein HV036_RS09120 ENOG410671Z uncharacterized protein ydiH HV036_RS09125 ENOG4108PNB DNA-binding transcriptional regulator HV036_RS09130 ENOG4108PNB DNA-binding transcriptional regulator HV036_RS09140 ENOG4108VCD Chaperone HV036_RS09145 ENOG4105CW0 outer membrane usher protein HV036_RS09165 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HV036_RS09180 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HV036_RS09185 ENOG4105BZU Histidine kinase HV036_RS09190 ENOG4108XDN Transcriptional regulator HV036_RS09205 ENOG4108Z4V iron-sulfur cluster assembly HV036_RS09210 ENOG4105DIW FeS assembly protein SUFB HV036_RS09215 ENOG4105C3K feS assembly ATPase SufC HV036_RS09220 ENOG4105JRK feS assembly protein SufD HV036_RS09225 ENOG4105C9B Cysteine desulfurase HV036_RS09230 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV036_RS09235 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV036_RS09245 ENOG4105CA9 Pyruvate kinase HV036_RS09250 ENOG4105C28 cystathionine HV036_RS09265 ENOG4108UMI ABC transporter, permease HV036_RS09270 ENOG4105D01 (LipO)protein HV036_RS09275 ENOG4105RFR Protein of unknown function (DUF2767) HV036_RS09315 ENOG4107B2H carbonic anhydrase HV036_RS09320 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HV036_RS09335 ENOG4107QI1 Mate efflux family protein HV036_RS09340 ENOG4108R6K riboflavin synthase, subunit alpha HV036_RS09345 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV036_RS09350 ENOG4105CZQ inner membrane transport protein YdhC HV036_RS09355 ENOG4105F52 Transcriptional regulator HV036_RS09360 ENOG4105ETE Transcriptional regulator (LacI family HV036_RS09370 ENOG4105F27 Major Facilitator HV036_RS09375 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV036_RS09380 ENOG4105K4H Nlp p60 protein HV036_RS09385 ENOG4105M2J Glutaredoxin HV036_RS09390 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HV036_RS09395 ENOG4108UYE Lactoylglutathione lyase HV036_RS09400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV036_RS09405 ENOG4108WUH Transcriptional regulator, TetR family HV036_RS09410 ENOG4105DIJ Phosphoethanolamine transferase HV036_RS09415 ENOG4105XZD Fe-S protein HV036_RS09420 ENOG4107RGM aldo keto reductase HV036_RS09425 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV036_RS09430 ENOG4105DSW Fusaric acid resistance protein HV036_RS09435 ENOG4105Y49 secretion protein, HlyD family HV036_RS09450 ENOG4105BZU Histidine kinase HV036_RS09455 ENOG4108XTF Outer Membrane Lipoprotein HV036_RS09460 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HV036_RS09465 ENOG410642K Lysozyme inhibitor HV036_RS09470 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HV036_RS09475 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HV036_RS09480 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV036_RS09485 ENOG4108K3A Glutathione S-transferase HV036_RS09490 ENOG4105DUX Transporter HV036_RS09495 ENOG4105CSM endonuclease III HV036_RS09505 ENOG4108UQQ Electron transport complex HV036_RS09510 ENOG4105D6A Electron transport complex HV036_RS09525 ENOG4105DGN Electron transport complex HV036_RS09530 ENOG4105M9B inner membrane protein ydgK HV036_RS09540 ENOG4106C6R beta-lactam resistance protein HV036_RS09545 ENOG4105D9R oxidoreductase HV036_RS09550 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HV036_RS09555 ENOG4105C87 Aminotransferase class I and II HV036_RS09565 ENOG4107R08 Integrase HV036_RS09685 ENOG4105CDU Replicative dna helicase HV036_RS09725 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HV036_RS09775 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HV036_RS09800 ENOG4108N0N Phage Terminase Large Subunit HV036_RS09945 ENOG4105Y50 Virulence Protein HV036_RS09965 ENOG4107P2S Transcriptional regulator HV036_RS09970 ENOG4106J39 exported protein HV036_RS09975 ENOG4105EIP mannose-6-phosphate isomerase HV036_RS09980 ENOG4107GFK fumarate HV036_RS09985 ENOG4105C9Q fumarate hydratase class II HV036_RS09990 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HV036_RS09995 ENOG4105JJR Histidine kinase HV036_RS10000 ENOG41066T8 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity) HV036_RS10005 ENOG4107EXC regulatoR HV036_RS10010 ENOG4105RA2 Membrane HV036_RS10015 ENOG410642E Short chain dehydrogenase HV036_RS10020 ENOG4105D5Q Arginine ornithine antiporter HV036_RS10025 ENOG4105C5D exported protein HV036_RS10030 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV036_RS10035 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV036_RS10040 ENOG4105D64 Mechanosensitive ion channel HV036_RS10045 ENOG4105Q9Y Universal stress protein HV036_RS10050 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV036_RS10055 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV036_RS10060 ENOG4105CFC Transporter HV036_RS10065 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HV036_RS10075 ENOG4106KR7 LysR family Transcriptional regulator HV036_RS10080 ENOG4108DG9 Smr protein MutS2 HV036_RS10085 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS10090 ENOG4107S5I aldo keto reductase HV036_RS10100 ENOG4105DZG Dehydrogenase HV036_RS10105 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF HV036_RS10125 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HV036_RS10135 ENOG4108IGT Dipeptidase HV036_RS10145 ENOG4105N1F Hnh endonuclease HV036_RS10150 ENOG4108M8W Monooxygenase HV036_RS10160 ENOG4105DSF transport protein HV036_RS10165 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HV036_RS10170 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HV036_RS10175 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HV036_RS10190 ENOG4105CTD carboxy-peptidase HV036_RS10195 ENOG4105D94 Major Facilitator Superfamily HV036_RS10200 ENOG4106NZI LysR family Transcriptional regulator HV036_RS10205 ENOG4105DAG ROK family HV036_RS10210 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV036_RS10215 ENOG4105CMQ Chloride channel HV036_RS10220 ENOG4108IJ8 ABC transporter HV036_RS10225 ENOG4105E90 ABC transporter HV036_RS10230 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV036_RS10235 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HV036_RS10245 ENOG4105ENX hydrolase HV036_RS10250 ENOG4105EQ2 LysR family Transcriptional regulator HV036_RS10255 ENOG4108UY2 Chloramphenicol acetyltransferase HV036_RS10260 ENOG4105X2V dna damage-inducible protein HV036_RS10265 ENOG4108NEM leader-binding protein dmsD HV036_RS10270 ENOG4107KGK dmso reductase anchor subunit HV036_RS10275 ENOG4105QAX Iron-sulfur HV036_RS10280 ENOG4107QY8 reductase HV036_RS10285 ENOG4105KBG Protein of unknown function (DUF1161) HV036_RS10300 ENOG4108MK9 spermidine N(1)-acetyltransferase HV036_RS10305 ENOG4105M5Q UPF0482 protein HV036_RS10315 ENOG4105CXK mandelate racemase muconate lactonizing HV036_RS10320 ENOG4105CPQ Dehydrogenase HV036_RS10330 ENOG4105DEI Mannitol dehydrogenase HV036_RS10335 ENOG41061EV selenium-binding protein YdfZ HV036_RS10340 ENOG4108U51 Universal stress protein HV036_RS10345 ENOG4107XBN GntR Family Transcriptional Regulator HV036_RS10350 ENOG4105EMU Dehydrogenase HV036_RS10355 ENOG4105DGW oligopeptidase A HV036_RS10360 ENOG4106IAW HV036_RS10365 ENOG4105VEQ Cold shock protein HV036_RS10370 ENOG4108RAV Conserved protein HV036_RS10375 ENOG4105Y50 Virulence Protein HV036_RS10380 ENOG4105KT5 UmuD protein HV036_RS10385 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV036_RS10405 ENOG4105D7N magnesium and cobalt transport protein CorA HV036_RS10420 ENOG4105DZG Dehydrogenase HV036_RS10435 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HV036_RS10445 ENOG4105C5I Dehydrogenase HV036_RS10450 ENOG4107H52 Dicarboxylate transport HV036_RS10455 ENOG410689M (LipO)protein HV036_RS10460 ENOG4105WXT Conserved Protein HV036_RS10465 ENOG4108WFR AraC Family Transcriptional Regulator HV036_RS10470 ENOG4105C26 Dehydrogenase HV036_RS10480 ENOG4105EUZ Beta-lactamase domain protein HV036_RS10485 ENOG4105F11 amine oxidase HV036_RS10490 ENOG4105DXM phenylacetic acid degradation protein HV036_RS10495 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HV036_RS10500 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HV036_RS10505 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HV036_RS10510 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HV036_RS10515 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV036_RS10520 ENOG4105E39 Enoyl-CoA hydratase HV036_RS10525 ENOG4108UKI Enoyl-CoA hydratase HV036_RS10530 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV036_RS10535 ENOG4108ZJI phenylacetic acid degradation protein HV036_RS10540 ENOG4105CHU acetyl-coa acetyltransferase HV036_RS10545 ENOG4105DZS Phenylacetate-CoA ligase HV036_RS10550 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HV036_RS10555 ENOG4108Z0R Transferase HV036_RS10560 ENOG4105C94 Transporter HV036_RS10570 ENOG4105EUZ Beta-lactamase domain protein HV036_RS10590 ENOG4107FW0 short-chain dehydrogenase reductase HV036_RS10605 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV036_RS10640 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HV036_RS10650 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HV036_RS10655 ENOG4105D3G Pseudouridine synthase HV036_RS10660 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HV036_RS10665 ENOG4105CQ7 ATP-dependent helicase HV036_RS10675 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HV036_RS10695 ENOG4107DB1 DUF218 domain HV036_RS10700 ENOG4105C26 Dehydrogenase HV036_RS10705 ENOG4105CPW cytochrome b561 HV036_RS10710 ENOG4105D9R oxidoreductase HV036_RS10715 ENOG4105E98 transcriptional regulator DeoR family HV036_RS10730 ENOG4108JJA ABC, transporter HV036_RS10735 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HV036_RS10760 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HV036_RS10785 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS10790 ENOG4105DDW LysR family Transcriptional regulator HV036_RS10795 ENOG4105E32 cytoplasmic protein HV036_RS10800 ENOG4105EBR Carboxylesterase HV036_RS10810 ENOG4105CHM Aminotransferase HV036_RS10815 ENOG4105E89 ABC transporter HV036_RS10820 ENOG4105DJ9 glucan biosynthesis protein HV036_RS10825 ENOG4108Z9I -acetyltransferase HV036_RS10830 ENOG4107WE3 acetyltransferase YdcK HV036_RS10835 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HV036_RS10840 ENOG41088CC tellurite resistance protein tehB HV036_RS10845 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HV036_RS10850 ENOG4105DEF Extracellular solute-binding protein, family 5 HV036_RS10855 ENOG4108KKZ (LipO)protein HV036_RS10870 ENOG4105DKK Benzoate HV036_RS10875 ENOG4108JCI Transcriptional regulator HV036_RS10880 ENOG4105CFP Peptidase U32 HV036_RS10885 ENOG4105RR0 Protein of unknown function (DUF2554) HV036_RS10895 ENOG4105ECQ AraC Family Transcriptional Regulator HV036_RS10915 ENOG4105C32 Amino acid ABC transporter (Permease) HV036_RS10925 ENOG4108JJB ABC transporter HV036_RS10930 ENOG4108IV0 ABC, transporter HV036_RS10935 ENOG4108MEK Metal-binding protein YodA HV036_RS10940 ENOG4105E5W Transporter HV036_RS10945 ENOG4108594 Permease of the drug metabolite transporter HV036_RS10950 ENOG4106DNR multiple antibiotic resistance protein HV036_RS10955 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HV036_RS10960 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HV036_RS10965 ENOG41082NP Multiple antibiotic resistance HV036_RS10970 ENOG4105F27 Major Facilitator HV036_RS10975 ENOG4105JAB phenazine biosynthesis protein, phzf family HV036_RS10980 ENOG4105JAB phenazine biosynthesis protein, phzf family HV036_RS10990 ENOG4105EGI Transcriptional regulator HV036_RS10995 ENOG4105C26 Dehydrogenase HV036_RS11000 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS11005 ENOG4105CSV Glutaminase HV036_RS11010 ENOG4105M0C cytoplasmic protein HV036_RS11015 ENOG4105BZU Histidine kinase HV036_RS11030 ENOG4105FFC UPF0187 protein HV036_RS11050 ENOG4108MBX Secretion Protein HV036_RS11060 ENOG4105EQR Transposase IS116 IS110 IS902 HV036_RS11070 ENOG4108J2P Alpha beta hydrolase fold HV036_RS11080 ENOG4105E0F Histidine kinase HV036_RS11095 ENOG4107VIJ nudix hydrolase HV036_RS11100 ENOG4105E98 transcriptional regulator DeoR family HV036_RS11140 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV036_RS11160 ENOG4105CW0 outer membrane usher protein HV036_RS11165 ENOG4108VCD Chaperone HV036_RS11180 ENOG4108VCD Chaperone HV036_RS11185 ENOG4105CW0 outer membrane usher protein HV036_RS11225 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV036_RS11235 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV036_RS11250 ENOG4107RSM transcriptional regulator HV036_RS11255 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV036_RS11260 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HV036_RS11265 ENOG4105F32 YngK protein HV036_RS11270 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HV036_RS11285 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS11290 ENOG4105WBN Transcriptional regulator (LacI family HV036_RS11305 ENOG4108M0B Sucrose porin HV036_RS11310 ENOG4105D7K pfkb domain protein HV036_RS11315 ENOG4105BZU Histidine kinase HV036_RS11330 ENOG4108UQS dipeptidase HV036_RS11335 ENOG4105DEF Extracellular solute-binding protein, family 5 HV036_RS11340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV036_RS11345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV036_RS11350 ENOG4105C3U ABC transporter HV036_RS11355 ENOG4107H6U ABC transporter HV036_RS11360 ENOG4108Z9K Osmotically inducible protein HV036_RS11365 ENOG4105EXG Transcriptional regulator HV036_RS11380 ENOG4105TPS biofilm-dependent modulation protein HV036_RS11385 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HV036_RS11390 ENOG4107R1I NAD-dependent malic enzyme HV036_RS11405 ENOG4105C5H ABC transporter HV036_RS11425 ENOG4105F27 Major Facilitator HV036_RS11435 ENOG4108MG3 formate dehydrogenase HV036_RS11440 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV036_RS11450 ENOG4105RPH Inner membrane protein YddG HV036_RS11455 ENOG4105FCK Membrane HV036_RS11470 ENOG4107QND Nitrite extrusion protein HV036_RS11475 ENOG4105CRU nitrate reductase, alpha subunit HV036_RS11480 ENOG4108IUE nitrate reductase beta subunit HV036_RS11485 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HV036_RS11490 ENOG4105D0D Nitrate reductase 2, gamma subunit HV036_RS11495 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HV036_RS11500 ENOG4108MEJ flavin reductase domain protein HV036_RS11505 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HV036_RS11510 ENOG4105YVS arsR family transcriptional regulator HV036_RS11515 ENOG4105W8I Transcriptional regulator HV036_RS11520 ENOG4105KD7 acetyltransferase HV036_RS11530 ENOG4105D1S lipid A biosynthesis HV036_RS11535 ENOG4105KZK Tautomerase pptA HV036_RS11540 ENOG4108N27 Glutathione S-transferase HV036_RS11545 ENOG4105EAB amino acid AbC transporter HV036_RS11550 ENOG4105CDA abc transporter atp-binding protein HV036_RS11565 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HV036_RS11580 ENOG4105DEN Luciferase family HV036_RS11590 ENOG4105EQ2 LysR family Transcriptional regulator HV036_RS11595 ENOG4105C85 amino acid HV036_RS11600 ENOG4108NS2 receptor HV036_RS11605 ENOG4105CHB tonB-dependent Receptor HV036_RS11610 ENOG4108WYP Transcriptional regulator HV036_RS11615 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HV036_RS11625 ENOG4108Z7F N-acetyltransferase HV036_RS11630 ENOG4108T9Y Inner membrane protein ydcZ HV036_RS11635 ENOG4105R71 cytoplasmic protein HV036_RS11640 ENOG4105DEF Extracellular solute-binding protein, family 5 HV036_RS11665 ENOG410654E Membrane HV036_RS11670 ENOG4108YS1 cytoplasmic protein HV036_RS11675 ENOG4108YS1 cytoplasmic protein HV036_RS11680 ENOG4105YP6 Domain of unknown function (DUF1869) HV036_RS11685 ENOG4105C26 Dehydrogenase HV036_RS11690 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV036_RS11700 ENOG4105C4M (Ubiquinol oxidase) subunit I HV036_RS11705 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV036_RS11715 ENOG41090X5 Heat shock protein hslJ HV036_RS11720 ENOG4105IKK cytoplasmic protein HV036_RS11725 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HV036_RS11730 ENOG4105FCK Membrane HV036_RS11750 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HV036_RS11755 ENOG4105C1J atp-dependent rna helicase HV036_RS11765 ENOG4107RX3 Mg2 transporter protein cora family protein HV036_RS11770 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS11815 ENOG4107QSI ABC, transporter HV036_RS11820 ENOG4105KXI murein peptide amidase A HV036_RS11825 ENOG4107S8C mandelate racemase muconate lactonizing HV036_RS11830 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HV036_RS11835 ENOG4108JU8 Transcriptional regulator HV036_RS11840 ENOG4106K28 UPF0283 membrane protein HV036_RS11845 ENOG4105CM6 amino acid regulated cytosolic protein HV036_RS11850 ENOG4105FKQ transcriptional regulator HV036_RS11855 ENOG4107EFV Outer membrane protein G HV036_RS11860 ENOG4108IJ9 (ABC) transporter HV036_RS11865 ENOG4107URF beta-phospho-glucomutase HV036_RS11870 ENOG4105C71 hydrolase family 65, central catalytic HV036_RS11875 ENOG4105CK5 oxidoreductase HV036_RS11880 ENOG4107TYA transient receptor potential locus HV036_RS11885 ENOG4107RRD Dehydrogenase HV036_RS11890 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HV036_RS11895 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HV036_RS11900 ENOG4105WEM extracellular solute-binding protein HV036_RS11905 ENOG4107QW3 Sucrose phosphorylase HV036_RS11910 ENOG4105NNG Peripheral inner membrane phage-shock protein HV036_RS11915 ENOG4105FM1 phage shock protein C HV036_RS11920 ENOG4105YYT phage shock protein B HV036_RS11925 ENOG41087YS Phage shock protein A HV036_RS11930 ENOG4105E51 psp operon transcriptional activator HV036_RS11935 ENOG4108J59 Extracellular solute-binding protein, family 5 HV036_RS11940 ENOG4108EKA peptide transport system, permease HV036_RS11945 ENOG4108EU3 peptide transport system, permease HV036_RS11950 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HV036_RS11955 ENOG4108JQ2 peptide transport system atp-binding protein HV036_RS11960 ENOG4108Q5F Tetr family transcriptional regulator HV036_RS11965 ENOG4108UQ8 endoribonuclease L-psp HV036_RS11970 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HV036_RS11975 ENOG4105Q4T oxidoreductase HV036_RS11980 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HV036_RS11985 ENOG4105BZU Histidine kinase HV036_RS11990 ENOG4105E39 Enoyl-CoA hydratase HV036_RS11995 ENOG410643D UPF0509 protein HV036_RS12000 ENOG4105N2W Transcriptional regulator HV036_RS12005 ENOG41061RM osmotically inducible lipoprotein HV036_RS12010 ENOG4108ZJT translation initiation factor, Sui1 HV036_RS12015 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HV036_RS12020 ENOG4105CFV Tetratricopeptide repeat protein HV036_RS12025 ENOG4105Q4A inner membrane protein yciS HV036_RS12030 ENOG4105EYK Phosphatidylglycerophosphatase B HV036_RS12035 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HV036_RS12040 ENOG4107QM5 aconitate hydratase HV036_RS12055 ENOG4107R11 Transcriptional regulator HV036_RS12060 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV036_RS12065 ENOG4105RKX Protein of unknown function (DUF2498) HV036_RS12070 ENOG4105ERU peptidase HV036_RS12075 ENOG4105UBK short-chain dehydrogenase reductase HV036_RS12080 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV036_RS12085 ENOG4105FE9 pseudouridine synthase HV036_RS12160 ENOG41090RK glycosyl transferase HV036_RS12165 ENOG4107RTD sua5 ycio yrdc ywlc family protein HV036_RS12170 ENOG4105DB7 PHP domain protein HV036_RS12180 ENOG4105CRQ synthase (Component I) HV036_RS12185 ENOG4108EFP Anthranilate synthase component II HV036_RS12190 ENOG4105DK0 Indole-3-glycerol phosphate synthase HV036_RS12195 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HV036_RS12200 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HV036_RS12205 ENOG41066VF YeeE YedE family protein HV036_RS12215 ENOG4105EIF outer membrane protein W HV036_RS12220 ENOG4105PI0 Ferredoxin HV036_RS12225 ENOG4108S3I UPF0259 membrane protein HV036_RS12230 ENOG4107835 probably involved in intracellular septation (By similarity) HV036_RS12235 ENOG4107RNH Outer membrane receptor FepA HV036_RS12240 ENOG4105NAU thioesterase Superfamily protein HV036_RS12245 ENOG410822N TonB family HV036_RS12250 ENOG4105K9H YciI-like protein HV036_RS12270 ENOG4108NIW Leucine export protein LeuE HV036_RS12285 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HV036_RS12290 ENOG4108W5H UPF0263 protein HV036_RS12295 ENOG4105EYW Ion transport protein HV036_RS12300 ENOG4108JQ7 (ABC) transporter HV036_RS12305 ENOG4105C3U ABC transporter HV036_RS12310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV036_RS12315 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV036_RS12320 ENOG4107QSI ABC, transporter HV036_RS12325 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HV036_RS12330 ENOG4105C0A alcohol dehydrogenase HV036_RS12335 ENOG4107104 thymidine kinase HV036_RS12345 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV036_RS12350 ENOG4105I93 response regulator HV036_RS12355 ENOG4105D78 K07001 NTE family protein HV036_RS12360 ENOG4105K5B UPF0225 protein HV036_RS12365 ENOG4105CIY formyltetrahydrofolate deformylase HV036_RS12380 ENOG41076YT nitrate reductase, gamma subunit HV036_RS12385 ENOG4105R3A Nitrate reductase HV036_RS12390 ENOG4108IUE nitrate reductase beta subunit HV036_RS12395 ENOG4105CRU nitrate reductase, alpha subunit HV036_RS12400 ENOG4105DQQ Major facilitator superfamily MFS_1 HV036_RS12405 ENOG4105BZU Histidine kinase HV036_RS12410 ENOG4105WH1 Two component transcriptional regulator luxr family HV036_RS12415 ENOG4105ID0 Putative invasin HV036_RS12425 ENOG4107QZF nitrite reductase NADPH large subunit HV036_RS12430 ENOG4105D7T ABC transporter HV036_RS12450 ENOG41090EX DsrE family HV036_RS12455 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS12465 ENOG4108NH8 Cation transport protein HV036_RS12470 ENOG4105WS7 Cation transport regulator HV036_RS12475 ENOG4105EWV Sodium calcium exchanger membrane region HV036_RS12480 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HV036_RS12485 ENOG41063JG Transcriptional regulator HV036_RS12490 ENOG4108YY7 Invasion gene expression up-regulator SirB HV036_RS12495 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HV036_RS12500 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HV036_RS12505 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HV036_RS12510 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HV036_RS12515 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HV036_RS12520 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HV036_RS12525 ENOG4105CHH sulfate transporter HV036_RS12535 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HV036_RS12540 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HV036_RS12545 ENOG4105C3G gtp-binding protein HV036_RS12595 ENOG4105CNA YD repeat protein HV036_RS12630 ENOG4105D9P serine threonine protein kinase HV036_RS12635 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV036_RS12695 ENOG4108WC9 type VI secretion system effector, hcp1 family HV036_RS12740 ENOG4106VK6 Flagellar motor protein HV036_RS12770 ENOG4105E53 ec 3.2.1.28 HV036_RS12775 ENOG4105E0K tonB-dependent siderophore receptor HV036_RS12780 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HV036_RS12785 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HV036_RS12790 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HV036_RS12795 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HV036_RS12800 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV036_RS12805 ENOG4105MWK D-amino acid dehydrogenase, small subunit HV036_RS12810 ENOG4105ED1 spovr family HV036_RS12820 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HV036_RS12825 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HV036_RS12830 ENOG4108ZZ3 UPF0260 protein HV036_RS12835 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HV036_RS12845 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HV036_RS12850 ENOG4107QMS site-determining protein HV036_RS12855 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HV036_RS12860 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HV036_RS12865 ENOG4105CEY Amp-dependent synthetase and ligase HV036_RS12870 ENOG4105Y4Z Outer Membrane Lipoprotein HV036_RS12875 ENOG41072GX Peptidase M22 Glycoprotease HV036_RS12880 ENOG4105DVT helicase HV036_RS12885 ENOG4105M4H endoribonuclease L-psp HV036_RS12890 ENOG4105X5C UPF0181 protein HV036_RS12895 ENOG4105CRQ synthase (Component I) HV036_RS12900 ENOG4105P8F nudix hydrolase HV036_RS12905 ENOG4105EJQ L-serine dehydratase HV036_RS12910 ENOG4107XTP (EAL) domain protein HV036_RS12915 ENOG4105EE5 Membrane protein terC HV036_RS12920 ENOG4105DAS pts system HV036_RS12925 ENOG4105ETZ PTS System HV036_RS12930 ENOG4105F3R pts system mannose fructose sorbose family iid HV036_RS12935 ENOG4108NK4 UPF0266 membrane protein HV036_RS12940 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HV036_RS12945 ENOG4105DHI Methyltransferase HV036_RS12950 ENOG4105CJN penicillin-binding protein HV036_RS12965 ENOG4105Q3Y exported protein HV036_RS12970 ENOG4106CCY Protein MgrB homolog HV036_RS12975 ENOG4105TIK HV036_RS12980 ENOG4105J4Q Transcriptional regulator HV036_RS12985 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV036_RS12990 ENOG4105D0M Protease HtpX homolog HV036_RS12995 ENOG4105CN1 protease HV036_RS13000 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HV036_RS13005 ENOG4108ZGC gaf domain protein HV036_RS13010 ENOG4105H2K paraquat-inducible protein a HV036_RS13015 ENOG4105DY2 Paraquat-inducible protein b HV036_RS13020 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HV036_RS13025 ENOG4105WT8 Protein of unknown function (DUF1480) HV036_RS13030 ENOG4108R1E Serine threonine protein phosphatase 1 HV036_RS13035 ENOG4108MJ5 VirK protein HV036_RS13040 ENOG4105NKT exported protein HV036_RS13045 ENOG4108PNC copper resistance HV036_RS13050 ENOG4105FXM Copper resistance protein HV036_RS13055 ENOG4105MPK DNA polymerase III subunit theta HV036_RS13060 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV036_RS13065 ENOG4105UMD exodeoxyribonuclease X HV036_RS13070 ENOG4105CUG Oligopeptidase b HV036_RS13075 ENOG4108Q2J Inner membrane protein YebE HV036_RS13080 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HV036_RS13095 ENOG4108UHU Aldolase HV036_RS13100 ENOG4105C01 Dihydroxy-acid dehydratase HV036_RS13105 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HV036_RS13110 ENOG4106KNT transcriptional regulator HV036_RS13115 ENOG4105CA9 Pyruvate kinase HV036_RS13120 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HV036_RS13125 ENOG4105DR5 peptidase HV036_RS13130 ENOG4105NXV High-affinity zinc uptake system protein HV036_RS13140 ENOG4105FAV ABC, transporter HV036_RS13145 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HV036_RS13150 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HV036_RS13155 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HV036_RS13160 ENOG4105CDY transcriptional regulatory protein HV036_RS13165 ENOG4108TIT dATP pyrophosphohydrolase HV036_RS13170 ENOG4105C9M aspartyl-trna synthetase HV036_RS13175 ENOG4105D3W isochorismatase HV036_RS13180 ENOG41081XQ Conserved Protein HV036_RS13185 ENOG4105WJG Glutathione HV036_RS13190 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HV036_RS13195 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HV036_RS13200 ENOG4106N3A copper homeostasis protein cutc HV036_RS13205 ENOG4106ZCM YecM protein HV036_RS13210 ENOG4105C75 arginyL-tRNA synthetase HV036_RS13225 ENOG4105F5H Glycosyl Hydrolase Family 88 HV036_RS13230 ENOG4105CT4 transporter HV036_RS13235 ENOG4105W13 flagellar protein HV036_RS13240 ENOG4105D7B Flagellar biosynthesis protein flha HV036_RS13245 ENOG4105D00 flagellar biosynthetic protein flhB HV036_RS13250 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HV036_RS13255 ENOG4108VYJ response regulator receiver protein HV036_RS13265 ENOG4105BZU Histidine kinase HV036_RS13270 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS13275 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS13305 ENOG4107QJT sodium dicarboxylate symporter HV036_RS13310 ENOG4108V3W Chemotaxis protein, CheW HV036_RS13315 ENOG4105CBS Chea signal transduction histidine kinase HV036_RS13320 ENOG4105ER2 Ompa motb domain protein HV036_RS13325 ENOG4107RD7 Flagellar Motor Protein, MotA HV036_RS13330 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HV036_RS13335 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HV036_RS13340 ENOG4108VA4 Universal stress protein HV036_RS13345 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HV036_RS13350 ENOG4108K4C ec 3.1.3.12 HV036_RS13355 ENOG4105CNN ABC, transporter HV036_RS13365 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HV036_RS13375 ENOG4108UEC Ferritin-like protein HV036_RS13380 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV036_RS13385 ENOG4105N4N Protein of unknown function (DUF2766) HV036_RS13410 ENOG41090A1 ferritin HV036_RS13415 ENOG4105VVZ metal-binding protein HV036_RS13420 ENOG4105E0U tyrosine-specific transport protein HV036_RS13425 ENOG4106RHG Yeca family HV036_RS13435 ENOG4105C32 Amino acid ABC transporter (Permease) HV036_RS13440 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV036_RS13445 ENOG4105C0Z ABC transporter HV036_RS13450 ENOG4108IV0 ABC, transporter HV036_RS13460 ENOG4105DQS Transcriptional regulator HV036_RS13490 ENOG4105DZR Type I site-specific deoxyribonuclease HV036_RS13500 ENOG4106RHG Yeca family HV036_RS13550 ENOG4108MXD gtp-binding protein HV036_RS13630 ENOG4105UZW Tail fiber assembly protein HV036_RS13725 ENOG4105ED4 portal protein HV036_RS13740 ENOG4105VZ1 Replication Protein HV036_RS13750 ENOG4105DFE Dna adenine methylase HV036_RS13795 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV036_RS13820 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HV036_RS13825 ENOG4105WH1 Two component transcriptional regulator luxr family HV036_RS13830 ENOG4105XVG cytoplasmic protein HV036_RS13835 ENOG4105VJY transcriptional regulator HV036_RS13840 ENOG4105CDA abc transporter atp-binding protein HV036_RS13845 ENOG4105E5Q amino acid AbC transporter HV036_RS13850 ENOG4105K6H D-cysteine desulfhydrase HV036_RS13855 ENOG4105EAB amino acid AbC transporter HV036_RS13860 ENOG4108M9K flagella biosynthesis protein FliZ HV036_RS13865 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV036_RS13870 ENOG4105I03 Flagellin HV036_RS13875 ENOG4105DTS flagellar hook-associated HV036_RS13880 ENOG4105MQ3 flagellar protein FliS HV036_RS13890 ENOG4105E5K Alpha-amylase HV036_RS13895 ENOG4108W9D (LipO)protein HV036_RS13900 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HV036_RS13905 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HV036_RS13910 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV036_RS13915 ENOG41090PJ Flagellar assembly protein HV036_RS13920 ENOG4108JIR Flagellum-specific ATP synthase HV036_RS13925 ENOG4105GSA Flagellar export protein flij HV036_RS13930 ENOG4105WF4 Flagellar hook-length control protein HV036_RS13935 ENOG4107ZI8 flagellar basal body-associated protein flil HV036_RS13940 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV036_RS13945 ENOG4105DD5 Flagellar motor switch protein HV036_RS13950 ENOG4105K0P flagellar biosynthesis protein HV036_RS13955 ENOG4105CN7 Flagellar biosynthetic protein FliP HV036_RS13965 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HV036_RS13970 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HV036_RS13980 ENOG4105YX3 cellular response to acidity HV036_RS13985 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase HV036_RS13995 ENOG4105VNZ cytoplasmic protein HV036_RS14000 ENOG4105CKW Inner membrane protein yedI HV036_RS14005 ENOG4105FDR Membrane HV036_RS14010 ENOG41090BB DNA mismatch endonuclease (vsr) HV036_RS14015 ENOG4105DVF Cytosine-specific methyltransferase HV036_RS14020 ENOG4105EST Metal Dependent Phosphohydrolase HV036_RS14025 ENOG4105FCK Membrane HV036_RS14030 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HV036_RS14035 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV036_RS14040 ENOG4108MRH transcriptional regulatory protein HV036_RS14060 ENOG4107GFK fumarate HV036_RS14075 ENOG4105CSH Transporter HV036_RS14085 ENOG4105F04 LysR family Transcriptional regulator HV036_RS14110 ENOG4105DUU IucA IucC family protein HV036_RS14115 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HV036_RS14130 ENOG4107R11 Transcriptional regulator HV036_RS14145 ENOG4108PXI ErfK YbiS YcfS YnhG HV036_RS14155 ENOG4108U51 Universal stress protein HV036_RS14160 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV036_RS14165 ENOG4105BZS acriflavin resistance protein HV036_RS14180 ENOG4105CSH Transporter HV036_RS14185 ENOG4105FYV Amp nucleosidase HV036_RS14190 ENOG4105DC7 peptidase M24 HV036_RS14200 ENOG4105UQX Mate efflux family protein HV036_RS14215 ENOG4105DR8 Membrane HV036_RS14220 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HV036_RS14225 ENOG4105DZ1 carboxypeptidase HV036_RS14230 ENOG4105CJB Exodeoxyribonuclease I HV036_RS14235 ENOG4105CUB amino acid HV036_RS14245 ENOG4105EQ1 Transcriptional regulator HV036_RS14250 ENOG4107SRH Nad-dependent epimerase dehydratase HV036_RS14260 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HV036_RS14270 ENOG4105CIH Imidazole acetol-phosphate transaminase HV036_RS14275 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HV036_RS14280 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HV036_RS14285 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HV036_RS14290 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HV036_RS14295 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HV036_RS14300 ENOG4105VNT transposase (IS4 family) protein HV036_RS14305 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HV036_RS14320 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HV036_RS14335 ENOG4107QKV phosphomannomutase HV036_RS14340 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HV036_RS14355 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HV036_RS14360 ENOG4105C1B dTDP-glucose 4-6-dehydratase HV036_RS14375 ENOG4107UKG Glycosyl transferase, family 4 HV036_RS14385 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV036_RS14390 ENOG4105G1A colanic acid biosynthesis protein HV036_RS14395 ENOG4107T8Q Glycosyl transferase (Group 1 HV036_RS14400 ENOG4105C74 pyruvyl transferase HV036_RS14405 ENOG4105PSV Polysaccharide Biosynthesis Protein HV036_RS14410 ENOG4105D3Q Sugar transferase HV036_RS14415 ENOG4107QKV phosphomannomutase HV036_RS14420 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HV036_RS14425 ENOG4106CD9 glycosyl transferase group 1 HV036_RS14430 ENOG4105FGF GDP-mannose mannosyl hydrolase HV036_RS14435 ENOG4105C30 Nad-dependent epimerase dehydratase HV036_RS14440 ENOG4105C0K Gdp-mannose 4,6-dehydratase HV036_RS14445 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HV036_RS14450 ENOG4105ECJ Glycosyl Transferase HV036_RS14455 ENOG4108NYJ Colanic acid HV036_RS14460 ENOG4107RXY Glycosyl transferase HV036_RS14465 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HV036_RS14470 ENOG41090RK glycosyl transferase HV036_RS14475 ENOG4105D75 Capsular exopolysaccharide family HV036_RS14480 ENOG4105KJF protein tyrosine phosphatase HV036_RS14485 ENOG4105DAY polysaccharide export protein HV036_RS14490 ENOG4105EE5 Membrane protein terC HV036_RS14495 ENOG4108GAE asmA family HV036_RS14500 ENOG4105DHP deoxycytidine triphosphate deaminase HV036_RS14510 ENOG4105BZU Histidine kinase HV036_RS14515 ENOG4105D03 DNA-3-methyladenine glycosylase II HV036_RS14520 ENOG4105R8A Heat shock protein HV036_RS14525 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV036_RS14530 ENOG4105BZS acriflavin resistance protein HV036_RS14535 ENOG4105BZS acriflavin resistance protein HV036_RS14540 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV036_RS14545 ENOG4105EB3 Histidine kinase HV036_RS14550 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV036_RS14555 ENOG4105CFP Peptidase U32 HV036_RS14570 ENOG4107TE5 Lipid kinase HV036_RS14575 ENOG4105EIE fructose-bisphosphate aldolase HV036_RS14580 ENOG4105EAA nucleoside HV036_RS14585 ENOG4108KD5 ADP-ribosylation crystallin J1 HV036_RS14590 ENOG4108TFM Kinase, PfkB family HV036_RS14595 ENOG4105FDP GntR family transcriptional regulator HV036_RS14600 ENOG4105DWF phosphomethylpyrimidine kinase HV036_RS14605 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HV036_RS14625 ENOG4108JPW Aminotransferase HV036_RS14630 ENOG4105DY8 decarboxylase HV036_RS14635 ENOG4108F2G Chain length determinant protein HV036_RS14640 ENOG4107ZF2 Phosphatase HV036_RS14645 ENOG4105DAY polysaccharide export protein HV036_RS14650 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HV036_RS14655 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HV036_RS14660 ENOG4105D1F ATP-binding protein HV036_RS14665 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HV036_RS14670 ENOG4108W15 Protein of unknown function (DUF1456) HV036_RS14675 ENOG4108NEV two component transcriptional regulator, LytTR family HV036_RS14680 ENOG4108HRK Histidine kinase HV036_RS14685 ENOG4108XDN Transcriptional regulator HV036_RS14695 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HV036_RS14700 ENOG4108IJ8 ABC transporter HV036_RS14705 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HV036_RS14710 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV036_RS14715 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HV036_RS14720 ENOG4105CXG d-lactate dehydrogenase HV036_RS14730 ENOG41061WM D-Alanyl-D-Alanine HV036_RS14735 ENOG41069YE inner membrane protein yohC HV036_RS14740 ENOG4105KHU inner membrane protein YohD HV036_RS14745 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HV036_RS14750 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV036_RS14755 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HV036_RS14760 ENOG4105VAW lrga family HV036_RS14765 ENOG41067MG lrgb family HV036_RS14770 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HV036_RS14775 ENOG4107GZ4 SanA protein HV036_RS14780 ENOG4107SDZ Galactoside transport system permease protein mglC HV036_RS14785 ENOG4105C2J ABC transporter HV036_RS14795 ENOG41060NJ transcriptional regulator HV036_RS14800 ENOG4105DHF Membrane HV036_RS14805 ENOG4105EUJ GTP cyclohydrolase i HV036_RS14810 ENOG4105CBP Major Facilitator HV036_RS14815 ENOG4105C4W S-formylglutathione hydrolase HV036_RS14820 ENOG4105D05 Receptor HV036_RS14825 ENOG4108IQI permease HV036_RS14830 ENOG4105DUM transcriptional regulator, lysR family HV036_RS14835 ENOG4105HMI Membrane HV036_RS14840 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HV036_RS14845 ENOG4105DM4 PTS System HV036_RS14850 ENOG4105DE4 1-phosphofructokinase HV036_RS14855 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV036_RS14860 ENOG4105S8Q sugar efflux transporter HV036_RS14865 ENOG4105KRS Proteinase inhibitor HV036_RS14870 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HV036_RS14875 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HV036_RS14880 ENOG4105DEI Mannitol dehydrogenase HV036_RS14885 ENOG4105CKI cobalamin synthesis protein HV036_RS14890 ENOG41076MN Phosphoesterase, PA-phosphatase related HV036_RS14895 ENOG4107TT5 NLP P60 protein HV036_RS14900 ENOG4105CXC rtn protein HV036_RS14905 ENOG4105E43 Extracellular solute-binding protein, family 5 HV036_RS14910 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HV036_RS14915 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HV036_RS14920 ENOG4108JQ5 ABC transporter HV036_RS14925 ENOG4105HG6 HV036_RS14930 ENOG4105C2C drug resistance transporter, Bcr CflA HV036_RS14935 ENOG4105I08 Pseudouridine synthase HV036_RS14940 ENOG4105CFI type iii restriction protein res subunit HV036_RS14945 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HV036_RS14950 ENOG4106V8H Nucleoid-associated protein HV036_RS14955 ENOG4105PAN UPF0352 protein HV036_RS14960 ENOG4105E68 Sulfatase HV036_RS14970 ENOG4105S5I Membrane HV036_RS14980 ENOG4105DWT malate dehydrogenase (quinone) HV036_RS14985 ENOG4105CHH sulfate transporter HV036_RS14990 ENOG4105CJW magnesium transporter HV036_RS14995 ENOG4105IBP Cyclic peptide transporter HV036_RS15000 ENOG4105CF1 Alkylated DNA repair protein HV036_RS15005 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV036_RS15020 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HV036_RS15025 ENOG41068CG regulatoR HV036_RS15030 ENOG4105BZU Histidine kinase HV036_RS15035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV036_RS15040 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HV036_RS15045 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV036_RS15050 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV036_RS15055 ENOG4105XPH Ferredoxin HV036_RS15060 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HV036_RS15065 ENOG4105CXY transporter HV036_RS15070 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HV036_RS15075 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HV036_RS15080 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV036_RS15085 ENOG4108EWA cinA-like protein HV036_RS15090 ENOG4108UII YfaZ family HV036_RS15095 ENOG4105DHQ Histidine kinase HV036_RS15120 ENOG4105CEY Amp-dependent synthetase and ligase HV036_RS15125 ENOG4105DNI Converts SHCHC to OSB (By similarity) HV036_RS15130 ENOG4108IPT Naphthoate synthase HV036_RS15135 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HV036_RS15140 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HV036_RS15145 ENOG4105E4F Isochorismate synthase HV036_RS15150 ENOG4105TNS Conserved Protein HV036_RS15155 ENOG4107YB6 acetyltransferase, (GNAT) family HV036_RS15160 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HV036_RS15170 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV036_RS15175 ENOG4105C8S subunit m HV036_RS15180 ENOG4105D65 subunit l HV036_RS15185 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV036_RS15190 ENOG4107UFS subunit j HV036_RS15200 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HV036_RS15205 ENOG4108IEH NADH dehydrogenase subunit g HV036_RS15210 ENOG4107QIZ NADH dehydrogenase HV036_RS15215 ENOG4105GKE subunit e HV036_RS15220 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV036_RS15225 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV036_RS15230 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HV036_RS15235 ENOG4107NQ8 LysR family Transcriptional regulator HV036_RS15240 ENOG4105CHM Aminotransferase HV036_RS15245 ENOG4105DK2 UPF0207 protein HV036_RS15250 ENOG4107QWE )-transporter HV036_RS15255 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HV036_RS15260 ENOG4105XWI UPF0304 protein HV036_RS15270 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV036_RS15275 ENOG4105C6K Malic enzyme HV036_RS15280 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HV036_RS15285 ENOG4108HHA Transketolase HV036_RS15290 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HV036_RS15300 ENOG4106ETB IIa component HV036_RS15305 ENOG4105K2J Transcriptional regulator HV036_RS15310 ENOG4105PTV Nudix Hydrolase HV036_RS15315 ENOG4108RE9 Phosphodiesterase HV036_RS15320 ENOG4108SHQ Glutathione S-transferase HV036_RS15325 ENOG4105CYM Glutathione S-transferase HV036_RS15330 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HV036_RS15335 ENOG4105ECP epimerase HV036_RS15340 ENOG4105D9U N-acetyltransferase HV036_RS15345 ENOG4108JEH abc transporter atp-binding protein HV036_RS15350 ENOG4106YG3 ABC transporter HV036_RS15355 ENOG4105DSP amino acid AbC transporter HV036_RS15360 ENOG4105E89 ABC transporter HV036_RS15365 ENOG4105E89 ABC transporter HV036_RS15370 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV036_RS15375 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HV036_RS15380 ENOG4105E96 Colicin v production protein HV036_RS15385 ENOG4108S3P Sporulation domain protein HV036_RS15390 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HV036_RS15395 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HV036_RS15400 ENOG4105DQR SNARE associated Golgi HV036_RS15405 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HV036_RS15410 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV036_RS15415 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HV036_RS15420 ENOG4106WZ1 flagella biosynthesis regulator HV036_RS15425 ENOG4105F9N Major Facilitator Superfamily HV036_RS15430 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV036_RS15435 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HV036_RS15440 ENOG4105MH2 YfcL protein HV036_RS15445 ENOG4108BPE -transporting atpase HV036_RS15450 ENOG4105EJ9 Membrane HV036_RS15455 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HV036_RS15460 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HV036_RS15465 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HV036_RS15470 ENOG4108DG9 Smr protein MutS2 HV036_RS15475 ENOG4108BY2 phosphohistidine phosphatase HV036_RS15480 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV036_RS15485 ENOG4105CHU acetyl-coa acetyltransferase HV036_RS15490 ENOG4105KZW UPF0381 protein HV036_RS15495 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HV036_RS15500 ENOG410903C (LipO)protein HV036_RS15505 ENOG4105S64 Formate nitrite transporter HV036_RS15515 ENOG4105D1S lipid A biosynthesis HV036_RS15525 ENOG4105CHM Aminotransferase HV036_RS15530 ENOG4108HRK Histidine kinase HV036_RS15535 ENOG4105DY9 regulatoR HV036_RS15540 ENOG4105CHC glucokinase (EC 2.7.1.2) HV036_RS15550 ENOG4107RA9 decarboxylase HV036_RS15555 ENOG4105CPC Aldo Keto reductase HV036_RS15565 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HV036_RS15570 ENOG4105D9N nucleoside HV036_RS15575 ENOG4108KMM Diguanylate cyclase HV036_RS15590 ENOG4105HZG regulatoR HV036_RS15595 ENOG4105GXM Putative transcription regulator (DUF1323) HV036_RS15600 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HV036_RS15630 ENOG4108M0I Transcriptional regulator HV036_RS15635 ENOG4105DHU Bile acid HV036_RS15640 ENOG4105VRT cytoplasmic protein HV036_RS15645 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HV036_RS15650 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HV036_RS15655 ENOG4105EXN Sulfate transport protein CysZ HV036_RS15660 ENOG4105C6T cysteine synthase HV036_RS15670 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV036_RS15675 ENOG4105C5Y PTS System HV036_RS15685 ENOG4105C6T cysteine synthase HV036_RS15690 ENOG4108IJ6 ABC transporter HV036_RS15695 ENOG4105ECW sulfate abc transporter HV036_RS15700 ENOG4108I5D sulfate abc transporter HV036_RS15705 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HV036_RS15710 ENOG4105EZR dyp-type peroxidase family protein HV036_RS15715 ENOG4105E7K (LipO)protein HV036_RS15720 ENOG4105QZU Inner membrane protein YfeZ HV036_RS15725 ENOG4108R6G acetyltransferase HV036_RS15730 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HV036_RS15735 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HV036_RS15740 ENOG4105C6K Malic enzyme HV036_RS15750 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV036_RS15755 ENOG4108PVD exported protein HV036_RS15760 ENOG4107VIJ nudix hydrolase HV036_RS15765 ENOG4105BZ8 glutamate synthase HV036_RS15770 ENOG4105BZU Histidine kinase HV036_RS15775 ENOG4105BZS acriflavin resistance protein HV036_RS15785 ENOG4105KUZ arsenate reductase HV036_RS15790 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HV036_RS15800 ENOG4106KED esterase YpfH HV036_RS15805 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HV036_RS15810 ENOG4105CGZ zinc metallopeptidase HV036_RS15815 ENOG4105C8V SAICAR synthetase HV036_RS15820 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV036_RS15830 ENOG4105RH4 Glycine cleavage system transcriptional repressor HV036_RS15835 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV036_RS15840 ENOG4105C02 permease HV036_RS15845 ENOG4105ERG peptidase m48, ste24p HV036_RS15850 ENOG4105K89 arsenate reductase HV036_RS15875 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HV036_RS15880 ENOG4105C2W permease HV036_RS15885 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HV036_RS15890 ENOG4105CS2 ec 3.2.1.21 HV036_RS15900 ENOG4108V3E phosphoribosylglycinamide formyltransferase HV036_RS15910 ENOG4105C9X ppx gppa phosphatase HV036_RS15915 ENOG4105BZU Histidine kinase HV036_RS15920 ENOG41062G3 Protein of unknown function (DUF2633) HV036_RS15935 ENOG4105Z4Q MltA-interacting MipA family protein HV036_RS15940 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV036_RS15960 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV036_RS15965 ENOG4105UEI Transcriptional Regulator AraC Family HV036_RS15985 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV036_RS15990 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HV036_RS15995 ENOG4105D4Y metalloprotease HV036_RS16005 ENOG4105VPD cellular component movement HV036_RS16010 ENOG4105DUX Transporter HV036_RS16015 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HV036_RS16020 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV036_RS16025 ENOG4105N21 Membrane HV036_RS16030 ENOG4105CUT histidyl-tRNA synthetase HV036_RS16035 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HV036_RS16045 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HV036_RS16050 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HV036_RS16060 ENOG4107KGK dmso reductase anchor subunit HV036_RS16065 ENOG4105QAX Iron-sulfur HV036_RS16075 ENOG4108JQB penicillin-binding protein 1C HV036_RS16080 ENOG4105DN3 alpha-2-macroglobulin domain protein HV036_RS16085 ENOG4105CI1 PTS System HV036_RS16095 ENOG4105KHC sulfurtransferase HV036_RS16100 ENOG4108Q3X Transcriptional regulator HV036_RS16105 ENOG4105YYA enhanced serine sensitivity protein SseB HV036_RS16110 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV036_RS16115 ENOG4105WVQ Fe-S assembly protein IscX HV036_RS16120 ENOG4108ZIT Ferredoxin, 2FE-2S HV036_RS16125 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HV036_RS16130 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HV036_RS16135 ENOG4108Z4V iron-sulfur cluster assembly HV036_RS16140 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HV036_RS16145 ENOG4105C3J Cysteine desulfurase HV036_RS16150 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV036_RS16155 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HV036_RS16160 ENOG4105ECY inositol monophosphatase HV036_RS16165 ENOG4105D7X high-affinity nickel-transporter HV036_RS16175 ENOG4108MN2 Stationary phase inducible protein CsiE HV036_RS16180 ENOG4105D8G Major Facilitator superfamily HV036_RS16185 ENOG4108SB3 DoxX Family HV036_RS16190 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HV036_RS16195 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV036_RS16200 ENOG4108YZA Nitrogen regulatory protein pii HV036_RS16205 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV036_RS16210 ENOG4108SKK alpha helix protein HV036_RS16215 ENOG4107WP9 Histidine kinase HV036_RS16220 ENOG4108ETH Formylglycinamide ribotide synthetase HV036_RS16225 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HV036_RS16230 ENOG4108Z6B deaminase HV036_RS16235 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HV036_RS16245 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HV036_RS16250 ENOG4106G6Q Transcriptional regulator HV036_RS16255 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HV036_RS16260 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HV036_RS16265 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HV036_RS16270 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HV036_RS16275 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HV036_RS16280 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HV036_RS16285 ENOG4105C3F Signal peptidase i HV036_RS16305 ENOG4105Y50 Virulence Protein HV036_RS16465 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HV036_RS16475 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HV036_RS16540 ENOG4105E98 transcriptional regulator DeoR family HV036_RS16590 ENOG41076J9 exonuclease VIII HV036_RS16620 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HV036_RS16640 ENOG4108IYU L-aspartate oxidase HV036_RS16645 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HV036_RS16650 ENOG4105C1J atp-dependent rna helicase HV036_RS16655 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HV036_RS16660 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HV036_RS16665 ENOG4105EIB trna rrna methyltransferase HV036_RS16670 ENOG4105K63 Thioredoxin HV036_RS16675 ENOG4106IUH DTW domain containing protein HV036_RS16680 ENOG4105CD5 CoA-binding domain protein HV036_RS16685 ENOG4105JIM Phosphatidylserine synthase HV036_RS16690 ENOG4105T42 (LipO)protein HV036_RS16695 ENOG4105CSH Transporter HV036_RS16725 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV036_RS16730 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HV036_RS16735 ENOG4105C34 Pseudouridine synthase HV036_RS16740 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV036_RS16745 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HV036_RS16755 ENOG4105CQC Prephenate dehydratase HV036_RS16765 ENOG4105ZTC transcriptional activator, Ogr delta HV036_RS16790 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HV036_RS16795 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV036_RS16800 ENOG4108WS1 HV036_RS16805 ENOG4108KHX Diguanylate cyclase HV036_RS16810 ENOG41090EK ompa motb domain protein HV036_RS16825 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HV036_RS16830 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HV036_RS16835 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HV036_RS16840 ENOG4105K5M 30s ribosomal protein S16 HV036_RS16845 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HV036_RS16850 ENOG4106KVJ cytochrome C assembly protein HV036_RS16855 ENOG4108JU6 CBS domain protein HV036_RS16860 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HV036_RS16865 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HV036_RS16870 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HV036_RS16875 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV036_RS16880 ENOG4105VDB UPF0125 protein HV036_RS16885 ENOG4108Z1B Cyclase dehydrase HV036_RS16900 ENOG4105DFP Integrase HV036_RS16905 ENOG4106QCB CP4-57 prophage HV036_RS16910 ENOG410679B prophage CP4-57 regulatory protein alpA HV036_RS16915 ENOG4108P8R HV036_RS16920 ENOG4105JXR Protein of unknown function (DUF3296) HV036_RS16950 ENOG4105VN1 Heat shock protein HV036_RS16955 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV036_RS17020 ENOG4105F2I Transposase HV036_RS17030 ENOG4105F9F transposase HV036_RS17040 ENOG4108MXD gtp-binding protein HV036_RS17045 ENOG4106H6R UPF0380 protein HV036_RS17050 ENOG4108KZE transcriptional regulator HV036_RS17065 ENOG4106J9S Prophage HV036_RS17090 ENOG4105MFG Antirestriction protein HV036_RS17095 ENOG4108XS9 dna repair protein HV036_RS17100 ENOG4105ZS6 Protein of unknown function (DUF987) HV036_RS17105 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV036_RS17110 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HV036_RS17115 ENOG4105D7V transposase HV036_RS17120 ENOG4105I03 Flagellin HV036_RS17170 ENOG4105CAR Terminase, large subunit HV036_RS17200 ENOG4105QYK bacteriophage lambda Bor protein homolog HV036_RS17220 ENOG4105NVB glycoside hydrolase, family 19 HV036_RS17240 ENOG4105HGD Antitermination protein HV036_RS17270 ENOG4108XTP Transcriptional regulator HV036_RS17310 ENOG4107R08 Integrase HV036_RS17315 ENOG4108RVA ribokinase HV036_RS17325 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HV036_RS17345 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HV036_RS17365 ENOG4105ETE Transcriptional regulator (LacI family HV036_RS17380 ENOG4108R85 Short chain dehydrogenase HV036_RS17385 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV036_RS17400 ENOG4105DND Transcriptional regulator HV036_RS17410 ENOG4105E7U AraC family transcriptional regulator HV036_RS17415 ENOG4107GJV short-chain dehydrogenase reductase HV036_RS17420 ENOG4105EMU Dehydrogenase HV036_RS17425 ENOG4105EQ2 LysR family Transcriptional regulator HV036_RS17450 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HV036_RS17465 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV036_RS17470 ENOG4105CR8 Transcriptional regulator HV036_RS17480 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV036_RS17485 ENOG4105DZC cytosine deaminase HV036_RS17490 ENOG4105C5B carbamate kinase HV036_RS17500 ENOG4107REC cytoplasmic protein HV036_RS17505 ENOG4107R1Q Membrane protein FdrA HV036_RS17510 ENOG4107SNB ankyrin repeat protein YahD HV036_RS17515 ENOG4108NUU Transcriptional regulator HV036_RS17520 ENOG4105VPI YqaE family transport protein HV036_RS17525 ENOG4108V62 Rhodanese domain protein HV036_RS17535 ENOG4108X73 DNA- binding protein HV036_RS17540 ENOG4108RNS Exports L-alanine (By similarity) HV036_RS17545 ENOG4108WMJ Protein of unknown function (DUF2002) HV036_RS17550 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HV036_RS17555 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HV036_RS17560 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HV036_RS17565 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV036_RS17570 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV036_RS17575 ENOG4108IJ7 Glycine betaine HV036_RS17580 ENOG4108HQS Glycine betaine HV036_RS17585 ENOG4105GIJ Glycine betaine HV036_RS17595 ENOG4105NTK Transcriptional repressor Mpra HV036_RS17600 ENOG4105CW7 secretion protein, HlyD family HV036_RS17605 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV036_RS17610 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HV036_RS17615 ENOG4105D9M gamma-glutamylcysteine synthetase HV036_RS17620 ENOG4105W39 Membrane HV036_RS17625 ENOG4107VXZ Hydrolase HV036_RS17655 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HV036_RS17660 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HV036_RS17670 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HV036_RS17675 ENOG4107TH8 cina domain protein HV036_RS17685 ENOG4105CC5 ABC transporter HV036_RS17690 ENOG4105DIK (ABC) transporter HV036_RS17695 ENOG4105CVE Lytic murein transglycosylase HV036_RS17700 ENOG410787A Pts system, glucitol sorbitol-specific HV036_RS17705 ENOG4105DZY Pts system, glucitol sorbitol-specific HV036_RS17710 ENOG4105VI0 Pts system, glucitol sorbitol-specific HV036_RS17715 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HV036_RS17720 ENOG4105J92 DNA-binding transcriptional activator GutM HV036_RS17725 ENOG410804X Transcriptional regulator HV036_RS17735 ENOG4108JUA Transcriptional regulator HV036_RS17740 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center HV036_RS17745 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HV036_RS17755 ENOG4105C8H hydrogenase maturation protein Hypf HV036_RS17760 ENOG4108RC0 Electron transport protein HV036_RS17765 ENOG4105DDV Transcriptional regulator (LacI family HV036_RS17770 ENOG4105C5Y PTS System HV036_RS17775 ENOG4105CS2 ec 3.2.1.21 HV036_RS17780 ENOG4108MG9 hydrogenase 3 maturation protease HV036_RS17785 ENOG4105I6X formate hydrogenlyase maturation HV036_RS17790 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HV036_RS17795 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HV036_RS17800 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV036_RS17805 ENOG4107TDF Formate hydrogenlyase subunit 4 HV036_RS17810 ENOG4107R30 NADH dehydrogenase HV036_RS17815 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV036_RS17820 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HV036_RS17825 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HV036_RS17830 ENOG4107RSS Hydrogenase accessory protein HypB HV036_RS17835 ENOG41083WG hydrogenase assembly chaperone HV036_RS17840 ENOG4105CQS hydrogenase expression formation protein HypD HV036_RS17845 ENOG4105C45 hydrogenase expression formation protein (HypE) HV036_RS17855 ENOG4105VXR cytoplasmic protein HV036_RS17865 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HV036_RS17870 ENOG4105KZM cytoplasmic protein HV036_RS17875 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV036_RS17880 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV036_RS17890 ENOG4105JQN Transcriptional regulator HV036_RS17895 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV036_RS17910 ENOG4108K5P (LipO)protein HV036_RS17920 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HV036_RS17925 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HV036_RS17930 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HV036_RS17935 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HV036_RS17940 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV036_RS17945 ENOG4105N0Z inner membrane protein ygbE HV036_RS17950 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) HV036_RS17960 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HV036_RS17965 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HV036_RS17970 ENOG4108MXK alkaline phosphatase isozyme conversion HV036_RS17975 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HV036_RS17985 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HV036_RS17990 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HV036_RS17995 ENOG41075H3 AraC family transcriptional regulator HV036_RS18000 ENOG4105CH2 amidohydrolase HV036_RS18010 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HV036_RS18015 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HV036_RS18020 ENOG4105CI1 PTS System HV036_RS18025 ENOG4105QEK Transcriptional regulator HV036_RS18030 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HV036_RS18035 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HV036_RS18040 ENOG4105DXN mazG family HV036_RS18045 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV036_RS18050 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HV036_RS18055 ENOG4105BZU Histidine kinase HV036_RS18060 ENOG4105BZW Glycerate kinase HV036_RS18065 ENOG4105EQX glucarate dehydratase HV036_RS18070 ENOG4105EQX glucarate dehydratase HV036_RS18075 ENOG4105DJB Major Facilitator Superfamily HV036_RS18080 ENOG4105QDK Flavodoxin HV036_RS18085 ENOG4105DR9 pseudouridine synthase HV036_RS18090 ENOG4105WP7 tRNA pseudouridine synthase C HV036_RS18095 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HV036_RS18105 ENOG4105EWT decarboxylase family HV036_RS18110 ENOG4105C44 Serine transporter HV036_RS18115 ENOG4105EJQ L-serine dehydratase HV036_RS18120 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HV036_RS18125 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HV036_RS18130 ENOG4105M08 Membrane HV036_RS18135 ENOG4105ETT transcriptional Regulator, LysR family HV036_RS18140 ENOG4105M5B (LipO)protein HV036_RS18145 ENOG4105C9B Cysteine desulfurase HV036_RS18150 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV036_RS18155 ENOG4105CUZ uba thif-type nad fad binding protein HV036_RS18160 ENOG4105CA3 membrane-bound lytic murein transglycosylase HV036_RS18180 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV036_RS18185 ENOG4107QZM n-acetylglutamate synthase HV036_RS18190 ENOG4107QYX exodeoxyribonuclease v alpha HV036_RS18195 ENOG4107QKA exodeoxyribonuclease V beta HV036_RS18200 ENOG4107QXK peptidase HV036_RS18205 ENOG4105DSY exodeoxyribonuclease V, gamma HV036_RS18210 ENOG4105RVB Prepilin peptidase dependent protein c HV036_RS18215 ENOG4105SEN Protein of unknown function (DUF2509) HV036_RS18220 ENOG4105JCS prepilin peptidase dependent protein HV036_RS18225 ENOG4105IPU prepilin peptidase dependent protein A HV036_RS18230 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HV036_RS18235 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HV036_RS18240 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HV036_RS18245 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HV036_RS18250 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HV036_RS18255 ENOG4105SUV lipoprotein YgdR HV036_RS18260 ENOG4105CPC Aldo Keto reductase HV036_RS18265 ENOG4107S74 Lysophospholipid transporter LplT HV036_RS18270 ENOG4105CEY Amp-dependent synthetase and ligase HV036_RS18275 ENOG41060NJ transcriptional regulator HV036_RS18285 ENOG4107YCY Transcriptional regulator HV036_RS18290 ENOG4105CS2 ec 3.2.1.21 HV036_RS18295 ENOG4105CK1 PTS System HV036_RS18300 ENOG4105DDV Transcriptional regulator (LacI family HV036_RS18310 ENOG4105RQF LysR family Transcriptional regulator HV036_RS18325 ENOG4108QY5 Ferric enterobactin transport protein HV036_RS18330 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HV036_RS18335 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HV036_RS18350 ENOG4107QNK )-transporter HV036_RS18355 ENOG4105CHR reductase HV036_RS18365 ENOG4105CAZ oligogalacturonide lyase HV036_RS18370 ENOG4108PU9 oligogalacturonate-specific porin HV036_RS18375 ENOG4105CHU acetyl-coa acetyltransferase HV036_RS18390 ENOG4108MHD transport protein HV036_RS18395 ENOG410830R acetyltransferase HV036_RS18400 ENOG4105VR1 Pfam:DUF1271 HV036_RS18410 ENOG4108Z9Z response to DNA damage stimulus HV036_RS18415 ENOG4108N8X transition metal ion binding HV036_RS18420 ENOG4105WEF catalase HV036_RS18425 ENOG4105C4M (Ubiquinol oxidase) subunit I HV036_RS18430 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV036_RS18435 ENOG4105CG3 alpha amylase, catalytic region HV036_RS18445 ENOG4108WTK competence damage-inducible protein HV036_RS18460 ENOG4108YDI single-species biofilm formation on inanimate substrate HV036_RS18465 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV036_RS18470 ENOG4105EUZ Beta-lactamase domain protein HV036_RS18485 ENOG4108PNB DNA-binding transcriptional regulator HV036_RS18490 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HV036_RS18495 ENOG4108NIW Leucine export protein LeuE HV036_RS18510 ENOG4105MN3 Resolvase HV036_RS18530 ENOG4108K5P (LipO)protein HV036_RS18535 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HV036_RS18540 ENOG4105CRK lysyL-tRNA synthetase HV036_RS18550 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HV036_RS18555 ENOG4105T95 Thiol disulfide interChange protein HV036_RS18560 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV036_RS18565 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HV036_RS18570 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HV036_RS18575 ENOG4105Y75 tpr repeat protein HV036_RS18580 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HV036_RS18585 ENOG4108UT2 hemolysin iii HV036_RS18590 ENOG4108Q3X Transcriptional regulator HV036_RS18595 ENOG4105CS2 ec 3.2.1.21 HV036_RS18615 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV036_RS18620 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV036_RS18625 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HV036_RS18635 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HV036_RS18640 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV036_RS18645 ENOG4105D0A hydroxylase HV036_RS18650 ENOG4107RAQ aminopeptidase HV036_RS18660 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HV036_RS18670 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HV036_RS18680 ENOG4108JQ1 Dehydrogenase HV036_RS18685 ENOG4105E66 phosphoriboisomerase A HV036_RS18690 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HV036_RS18695 ENOG4105MPN Membrane HV036_RS18700 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HV036_RS18705 ENOG4105D64 Mechanosensitive ion channel HV036_RS18710 ENOG4105D2N Aldolase HV036_RS18715 ENOG4105BZA Phosphoglycerate kinase HV036_RS18720 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV036_RS18725 ENOG4107Z1W Fructose transport system kinase HV036_RS18730 ENOG4108R4K DNA-binding, transcriptional regulator HV036_RS18735 ENOG4108Q8A Fructose-1,6-bisphosphatase HV036_RS18740 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HV036_RS18745 ENOG4105CTS PTS system mannitol-specific HV036_RS18750 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV036_RS18755 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV036_RS18760 ENOG4108K0D peptidase, M48 HV036_RS18775 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HV036_RS18780 ENOG4105CHR reductase HV036_RS18785 ENOG410832A alpha/beta hydrolase fold HV036_RS18800 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HV036_RS18810 ENOG4108FUF Transcriptional regulator, IclR family HV036_RS18815 ENOG4105CHR reductase HV036_RS18840 ENOG4105CYW agmatinase HV036_RS18845 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HV036_RS18860 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HV036_RS18865 ENOG4107QNK )-transporter HV036_RS18870 ENOG4105GPY SprT protein HV036_RS18875 ENOG4105RWS endonuclease I HV036_RS18880 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HV036_RS18885 ENOG4105D7Z glutathione synthase HV036_RS18890 ENOG4108UJU UPF0301 protein HV036_RS18900 ENOG4105CZX twitching motility protein HV036_RS18905 ENOG4105DFA alanine racemase domain protein HV036_RS18910 ENOG4108VIA integral membrane protein HV036_RS18915 ENOG4105VZ9 UPF0235 protein HV036_RS18925 ENOG4105CSA Coproporphyrinogen iii oxidase HV036_RS18930 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HV036_RS18935 ENOG4105K33 Periplasmic Protein HV036_RS18940 ENOG41090ED Protein with unknown function (DUF469) HV036_RS18950 ENOG4105CEN a g-specific adenine glycosylase HV036_RS18955 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HV036_RS18960 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HV036_RS18965 ENOG4105EAA nucleoside HV036_RS18970 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HV036_RS18980 ENOG4105CHY citrate lyase, alpha HV036_RS18985 ENOG4105CI0 Citrate lyase HV036_RS18990 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HV036_RS18995 ENOG4105DUA (citrate (pro-3S)-lyase ligase HV036_RS19000 ENOG4105ERH Fumarylacetoacetate hydrolase HV036_RS19005 ENOG4105D2K citrate carrier protein HV036_RS19010 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV036_RS19015 ENOG4106YYS transcriptional regulatory protein HV036_RS19020 ENOG4105CXN decarboxylase HV036_RS19025 ENOG4108UQV Membrane HV036_RS19045 ENOG4105BZU Histidine kinase HV036_RS19050 ENOG4105WH1 Two component transcriptional regulator luxr family HV036_RS19070 ENOG4108TUY outer membrane protein PgaA HV036_RS19075 ENOG4107BJW polysaccharide deacetylase HV036_RS19080 ENOG4105CND Glycosyl transferase, family 2 HV036_RS19090 ENOG4106032 Glutathionylspermidine synthase HV036_RS19095 ENOG4105CYM Glutathione S-transferase HV036_RS19100 ENOG4107EDW L-fucose operon activator HV036_RS19105 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS19115 ENOG4105CPC Aldo Keto reductase HV036_RS19120 ENOG4108TEB UPF0114 protein HV036_RS19140 ENOG4108ZZF transport protein (ExbD) HV036_RS19145 ENOG4105CWK Biopolymer transport protein, ExbB HV036_RS19150 ENOG4105C28 cystathionine HV036_RS19155 ENOG4108K81 inner membrane protein YghB HV036_RS19160 ENOG4105CF7 AraC family transcriptional regulator HV036_RS19165 ENOG4108I6A alcohol dehydrogenase HV036_RS19170 ENOG4105CV8 reductase HV036_RS19210 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HV036_RS19255 ENOG4105E2A Dehydrogenase HV036_RS19280 ENOG4107RT3 EamA-like transporter family HV036_RS19285 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HV036_RS19290 ENOG4105EQ2 LysR family Transcriptional regulator HV036_RS19295 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV036_RS19300 ENOG4105WAB arsR family transcriptional regulator HV036_RS19315 ENOG4108YXQ IS66 Orf2 family protein HV036_RS19360 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HV036_RS19365 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HV036_RS19370 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV036_RS19375 ENOG4105H4F exported protein HV036_RS19380 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV036_RS19385 ENOG4105DHQ Histidine kinase HV036_RS19390 ENOG4105NF4 modulator of drug activity HV036_RS19395 ENOG4105VRH Antibiotic biosynthesis monooxygenase HV036_RS19400 ENOG4109066 lysm domain bon superfamily protein HV036_RS19410 ENOG4105EP8 Glycosyl Hydrolase Family 88 HV036_RS19415 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV036_RS19440 ENOG4105EHG Permease protein HV036_RS19445 ENOG4105DQ5 transport system permease protein HV036_RS19450 ENOG4105E0A ABC, transporter HV036_RS19460 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV036_RS19465 ENOG4105IPS esterase HV036_RS19470 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HV036_RS19475 ENOG4108SX3 cytoplasmic protein HV036_RS19480 ENOG41087AY ADP-Ribose pyrophosphatase HV036_RS19490 ENOG4105F1G UPF0441 protein HV036_RS19495 ENOG4106032 Glutathionylspermidine synthase HV036_RS19500 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HV036_RS19510 ENOG4106UBK fimbrial-like adhesin protein HV036_RS19515 ENOG4106PG1 outer membrane usher protein HV036_RS19520 ENOG4108TTM chaperone HV036_RS19530 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HV036_RS19535 ENOG4105W0Z cytoplasmic protein HV036_RS19540 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HV036_RS19545 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HV036_RS19550 ENOG4105I7R Adenylate cyclase HV036_RS19555 ENOG4106MWK domain protein HV036_RS19560 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HV036_RS19570 ENOG4107ZVW dihydroneopterin aldolase HV036_RS19580 ENOG4105C54 Major Facilitator superfamily HV036_RS19585 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV036_RS19590 ENOG4108YZ9 Urea amidohydrolase subunit gamma HV036_RS19595 ENOG4105KI2 Urea amidohydrolase subunit beta HV036_RS19600 ENOG4105CQM Urea amidohydrolase subunit alpha HV036_RS19605 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HV036_RS19615 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV036_RS19620 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HV036_RS19635 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HV036_RS19640 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV036_RS19645 ENOG4108VCA G U mismatch-specific DNA glycosylase HV036_RS19655 ENOG4105ZTC transcriptional activator, Ogr delta HV036_RS19695 ENOG4105UZW Tail fiber assembly protein HV036_RS19765 ENOG4105Y5J prophage protein HV036_RS19775 ENOG4105EFV Major head subunit HV036_RS19785 ENOG4108TVE i protein HV036_RS19805 ENOG4105QIB mu-like prophage Flumu protein gp29 HV036_RS19845 ENOG4105NVB glycoside hydrolase, family 19 HV036_RS19920 ENOG4108WTW DNA transposition protein HV036_RS19930 ENOG4105HVQ Regulatory factor of maltose metabolism HV036_RS19950 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV036_RS19955 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HV036_RS19960 ENOG4105C7B Threonine dehydratase HV036_RS19965 ENOG410811B TRANSCRIPTIONal HV036_RS19975 ENOG4105BZW Glycerate kinase HV036_RS19980 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV036_RS19985 ENOG4105CNV Aldolase HV036_RS19990 ENOG4105CTX dehydratase HV036_RS19995 ENOG4105E98 transcriptional regulator DeoR family HV036_RS20000 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HV036_RS20005 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HV036_RS20015 ENOG4105F3R pts system mannose fructose sorbose family iid HV036_RS20020 ENOG4105YHU PTS system HV036_RS20025 ENOG4105CE4 GlcNAc 6-P deacetylase HV036_RS20030 ENOG4105E70 isomerase HV036_RS20035 ENOG4105D2N Aldolase HV036_RS20040 ENOG4105CI1 PTS System HV036_RS20055 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HV036_RS20060 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HV036_RS20065 ENOG41082RQ UPF0102 protein HV036_RS20070 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HV036_RS20075 ENOG4105W4M Transport-associated protein HV036_RS20080 ENOG4107S21 permease HV036_RS20085 ENOG4105K4T epimerase HV036_RS20090 ENOG4107R7Y intracellular protease Pfpi family HV036_RS20095 ENOG4108ZPB UPF0306 protein HV036_RS20100 ENOG41082IR Excinuclease ABC C subunit domain protein HV036_RS20105 ENOG4108YYD acetyltransferase HV036_RS20125 ENOG4105DEN Luciferase family HV036_RS20130 ENOG4105CIC tryptophan-specific transport protein HV036_RS20135 ENOG4105C1J atp-dependent rna helicase HV036_RS20150 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HV036_RS20155 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HV036_RS20160 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HV036_RS20165 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HV036_RS20170 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HV036_RS20175 ENOG4105CHV Transcription elongation factor NusA HV036_RS20180 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HV036_RS20190 ENOG4105CDH Citrulline--aspartate ligase HV036_RS20200 ENOG4105NTZ Preprotein translocase subunit SecG HV036_RS20205 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HV036_RS20210 ENOG4105EEI dihydropteroate synthase HV036_RS20215 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HV036_RS20220 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HV036_RS20225 ENOG4105HBR Rna-binding protein HV036_RS20230 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HV036_RS20235 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HV036_RS20250 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HV036_RS20255 ENOG4105QYV Membrane HV036_RS20260 ENOG4105K46 50S ribosomal protein l27 HV036_RS20265 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HV036_RS20270 ENOG4105EAH synthase HV036_RS20275 ENOG4105HVQ Regulatory factor of maltose metabolism HV036_RS20280 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HV036_RS20285 ENOG4105VFK BolA family HV036_RS20290 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HV036_RS20295 ENOG4105E3I toluene tolerance HV036_RS20300 ENOG4107PE3 Mammalian cell entry related domain protein HV036_RS20305 ENOG4105CY3 ABC transporter, permease HV036_RS20310 ENOG4105DHJ ABC, transporter HV036_RS20315 ENOG4105FEU K -dependent Na -Ca exchanger HV036_RS20320 ENOG4105C2X Arabinose 5-phosphate isomerase HV036_RS20325 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HV036_RS20330 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HV036_RS20335 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HV036_RS20340 ENOG4108IUZ ABC transporter HV036_RS20345 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV036_RS20350 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HV036_RS20355 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HV036_RS20360 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HV036_RS20365 ENOG41080Z8 PHOSPHOCARRIER protein HV036_RS20370 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HV036_RS20375 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HV036_RS20380 ENOG4105BZU Histidine kinase HV036_RS20385 ENOG4108K5H permease YjgP YjgQ family protein HV036_RS20390 ENOG4108M8S permease YjgP YjgQ family protein HV036_RS20395 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV036_RS20400 ENOG4105MYG DNA polymerase iii, chi subunit HV036_RS20405 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HV036_RS20410 ENOG4108MJ3 acetyltransferase HV036_RS20415 ENOG4105DQ4 alcohol dehydrogenase HV036_RS20425 ENOG4105D7A ATP-binding protein HV036_RS20430 ENOG4105N5T Radical SAM Protein HV036_RS20435 ENOG4105CBC glutamate synthase HV036_RS20440 ENOG4105BZ8 glutamate synthase HV036_RS20445 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HV036_RS20450 ENOG4105DZC cytosine deaminase HV036_RS20455 ENOG4105UMR response to DNA damage stimulus HV036_RS20465 ENOG4105E6S usher protein( HV036_RS20470 ENOG4108S1B Periplasmic chaperone protein HV036_RS20475 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon HV036_RS20480 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon HV036_RS20485 ENOG4105KB2 stringent starvation protein b HV036_RS20490 ENOG4107MKT Stringent starvation protein a HV036_RS20495 ENOG4108UJD 30S ribosomal protein S9 HV036_RS20505 ENOG4105D6Z AFG1 family ATPase HV036_RS20510 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HV036_RS20515 ENOG4105C0H protease HV036_RS20520 ENOG4105C0H protease HV036_RS20530 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HV036_RS20535 ENOG4105RID UPF0379 protein yhcN HV036_RS20540 ENOG4105UNR (Barnase) inhibitor HV036_RS20545 ENOG4105C26 Dehydrogenase HV036_RS20550 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HV036_RS20560 ENOG4105ZQC membrane protein AaeX HV036_RS20565 ENOG4105CR8 Transcriptional regulator HV036_RS20570 ENOG4105D1U peptidase U62 modulator of DNA gyrase HV036_RS20575 ENOG4105QD6 exported protein HV036_RS20580 ENOG4105C03 ribonuclease HV036_RS20590 ENOG4105VQ7 Rod shape-determining protein MreD HV036_RS20595 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HV036_RS20605 ENOG41062P1 Diguanylate cyclase phosphodiesterase HV036_RS20610 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HV036_RS20615 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HV036_RS20620 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HV036_RS20625 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HV036_RS20630 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HV036_RS20635 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HV036_RS20640 ENOG4105RG0 Membrane HV036_RS20645 ENOG4108IA2 Sodium pantothenate symporter HV036_RS20660 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV036_RS20670 ENOG41061ME transport protein HV036_RS20675 ENOG4105BZU Histidine kinase HV036_RS20680 ENOG4108XG4 DNA-binding transcriptional regulator HV036_RS20685 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV036_RS20690 ENOG4105BZS acriflavin resistance protein HV036_RS20695 ENOG4105XCM membrane LIPOPROTEIN HV036_RS20730 ENOG4108Z0R Transferase HV036_RS20735 ENOG4105SG3 Protein of unknown function (DUF1488) HV036_RS20740 ENOG4105E2X shikimate dehydrogenase HV036_RS20745 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV036_RS20750 ENOG4108WI1 Dna topoisomerase HV036_RS20755 ENOG4108RPN Protein smg homolog HV036_RS20760 ENOG4105C79 DNA protecting protein DprA HV036_RS20765 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HV036_RS20770 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HV036_RS20775 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HV036_RS20780 ENOG4105C1A potassium transporter peripheral membrane HV036_RS20785 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HV036_RS20790 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HV036_RS20795 ENOG4105W1Y Transcriptional regulator HV036_RS20800 ENOG4105VTS DnaJ-like, subfamily C HV036_RS20810 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV036_RS20815 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HV036_RS20820 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HV036_RS20830 ENOG41067V7 50S ribosomal protein L36 HV036_RS20835 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HV036_RS20845 ENOG4105VPB 50S ribosomal protein L30 HV036_RS20860 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HV036_RS20865 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HV036_RS20870 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HV036_RS20880 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HV036_RS20885 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HV036_RS20895 ENOG41083MP 50s ribosomal protein l29 HV036_RS20900 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HV036_RS20910 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HV036_RS20950 ENOG4108UQY Iron-storage protein HV036_RS20955 ENOG4105W53 bacterioferritin-associated ferredoxin HV036_RS20960 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HV036_RS20965 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HV036_RS20980 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV036_RS20985 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV036_RS20990 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HV036_RS20995 ENOG4105WWK YheO domain protein HV036_RS21000 ENOG4108V1T peptidylprolyl cis-trans isomerase HV036_RS21005 ENOG4105VRX Protein slyX homolog HV036_RS21010 ENOG4108YZY peptidylprolyl cis-trans isomerase HV036_RS21015 ENOG4105VKU nucleicacid-binding protein HV036_RS21020 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV036_RS21025 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HV036_RS21030 ENOG4105C5H ABC transporter HV036_RS21035 ENOG4108K70 Transcriptional regulator HV036_RS21040 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV036_RS21045 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HV036_RS21050 ENOG4107TT2 Auxin Efflux Carrier HV036_RS21080 ENOG4105DNZ Alpha Beta Hydrolase HV036_RS21085 ENOG4105YP7 UPF0270 protein HV036_RS21090 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HV036_RS21095 ENOG4108UKZ OsmC family HV036_RS21100 ENOG4107RYR Transcriptional regulator, Crp Fnr family HV036_RS21105 ENOG410613R integral membrane protein, YccS YhfK family HV036_RS21110 ENOG4105C8Y Acetylornithine aminotransferase HV036_RS21115 ENOG4105DDQ anthranilate synthase HV036_RS21120 ENOG4105MZU cell filamentation protein HV036_RS21125 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV036_RS21130 ENOG4106DTQ Protein TsgA homolog HV036_RS21135 ENOG4107QZF nitrite reductase NADPH large subunit HV036_RS21140 ENOG4105WZK nitrite reductase NADPH small subunit HV036_RS21145 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HV036_RS21150 ENOG4105VYH HV036_RS21155 ENOG4105C31 Tryptophanyl-tRNA synthetase HV036_RS21165 ENOG4105DJV ribulose-phosphate 3-epimerase HV036_RS21170 ENOG4105DFE Dna adenine methylase HV036_RS21175 ENOG4105EGB membrane protein DamX HV036_RS21180 ENOG4105D49 3-dehydroquinate synthase HV036_RS21185 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV036_RS21210 ENOG4108U1Q Pilus assembly protein HV036_RS21215 ENOG4108JQC penicillin-binding protein 1A HV036_RS21220 ENOG4107RK2 ADP-ribose diphosphatase NudE HV036_RS21225 ENOG4105DQY intracellular growth attenuator HV036_RS21230 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HV036_RS21235 ENOG4105VEJ Heat shock protein HV036_RS21240 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HV036_RS21245 ENOG4108MAJ Membrane HV036_RS21250 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HV036_RS21255 ENOG4105E0F Histidine kinase HV036_RS21265 ENOG4108RRZ Transcription elongation factor GreB HV036_RS21270 ENOG4105BZM domain protein HV036_RS21275 ENOG4105XFK Ferrous iron transport protein A HV036_RS21285 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HV036_RS21290 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HV036_RS21295 ENOG4105MJ2 Competence protein HV036_RS21300 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HV036_RS21305 ENOG4105C6Z Gluconate HV036_RS21310 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HV036_RS21315 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV036_RS21320 ENOG41061ZR Transcriptional regulator HV036_RS21325 ENOG4105E98 transcriptional regulator DeoR family HV036_RS21330 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HV036_RS21335 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HV036_RS21340 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HV036_RS21345 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV036_RS21350 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HV036_RS21355 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HV036_RS21360 ENOG4108ESZ Glycogen debranching enzyme HV036_RS21365 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV036_RS21370 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV036_RS21375 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HV036_RS21380 ENOG4105C6Z Gluconate HV036_RS21385 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV036_RS21390 ENOG4105DIQ Transcriptional regulator HV036_RS21395 ENOG4105C2I pirin domain protein HV036_RS21400 ENOG4105D9R oxidoreductase HV036_RS21405 ENOG4105WCN acetyltransferase HV036_RS21410 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HV036_RS21415 ENOG4105WC8 Conserved Protein HV036_RS21420 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HV036_RS21435 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HV036_RS21440 ENOG4105BZ7 extracellular solute-binding protein family 1 HV036_RS21445 ENOG4108IV0 ABC, transporter HV036_RS21450 ENOG4105C0Z ABC transporter HV036_RS21455 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV036_RS21460 ENOG4105C32 Amino acid ABC transporter (Permease) HV036_RS21465 ENOG4105CP9 extracellular ligand-binding receptor HV036_RS21470 ENOG4105U59 -acetyltransferase HV036_RS21475 ENOG4105CP9 extracellular ligand-binding receptor HV036_RS21480 ENOG4108JPW Aminotransferase HV036_RS21485 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV036_RS21490 ENOG4105CRP Part of the ABC transporter FtsEX involved in HV036_RS21495 ENOG4105CAK Cell division ATP-binding protein ftsE HV036_RS21500 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HV036_RS21505 ENOG4106H78 methyltransferase HV036_RS21510 ENOG4105MG3 Membrane HV036_RS21520 ENOG4107FS9 Membrane HV036_RS21525 ENOG4105C59 p-type ATPase HV036_RS21530 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV036_RS21540 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV036_RS21545 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HV036_RS21550 ENOG4105EX9 Membrane HV036_RS21555 ENOG4108W1V Lipoprotein HV036_RS21560 ENOG4105DSF transport protein HV036_RS21600 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HV036_RS21625 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV036_RS21635 ENOG4105C2D reductase HV036_RS21640 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV036_RS21645 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HV036_RS21650 ENOG4105PY6 Phenolic acid decarboxylase HV036_RS21655 ENOG4105ETT transcriptional Regulator, LysR family HV036_RS21660 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HV036_RS21680 ENOG4105GR3 Histidine kinase HV036_RS21685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV036_RS21690 ENOG4108PG2 copper resistance HV036_RS21695 ENOG4105JDN Copper resistance protein HV036_RS21700 ENOG4105VR0 copper resistance HV036_RS21705 ENOG4105E3B Multicopper oxidase HV036_RS21715 ENOG4105DR5 peptidase HV036_RS21745 ENOG410624V efflux system protein HV036_RS21810 ENOG4105CBX hi0933 family HV036_RS21815 ENOG4105CJ3 phosphate transporter HV036_RS21820 ENOG4108V6B universal stress protein B HV036_RS21830 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HV036_RS21835 ENOG4105DGW oligopeptidase A HV036_RS21840 ENOG4105D6S protein involved in catabolism of external DNA HV036_RS21845 ENOG4105DC8 reductase HV036_RS21870 ENOG4106S2D Transcriptional regulator HV036_RS21875 ENOG4105CHR reductase HV036_RS21880 ENOG4105CBN LysR family transcriptional regulator HV036_RS21885 ENOG4107H3J ribonuclease HV036_RS21890 ENOG4105CSH Transporter HV036_RS21895 ENOG41066T0 asmA family HV036_RS21900 ENOG4105CMB EAL domain-containing protein HV036_RS21910 ENOG4105CS0 peptidase HV036_RS21915 ENOG4105CK2 sodium dicarboxylate symporter HV036_RS21920 ENOG4105BZU Histidine kinase HV036_RS21925 ENOG4105EJG cellulose synthase HV036_RS21930 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HV036_RS21935 ENOG4107EEX Cellulose synthase regulator protein HV036_RS21940 ENOG4107QZ7 Cellulose synthase catalytic subunit HV036_RS21945 ENOG4105UTS cellulose synthase operon protein YhjQ HV036_RS21950 ENOG410661M cytoplasmic protein HV036_RS21960 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HV036_RS21965 ENOG4105D1V cellulose synthase operon protein YhjU HV036_RS21970 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HV036_RS21975 ENOG4105D4A Cell wall formation (By similarity) HV036_RS22005 ENOG4108RR8 protoporphyrinogen oxidase HV036_RS22010 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV036_RS22015 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HV036_RS22020 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HV036_RS22025 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV036_RS22030 ENOG4105CHU acetyl-coa acetyltransferase HV036_RS22035 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HV036_RS22040 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit HV036_RS22050 ENOG4105MEV Acyl-transferase HV036_RS22055 ENOG4105CMG Carbohydrate kinase HV036_RS22060 ENOG4105C93 Xylose Isomerase HV036_RS22065 ENOG4105DFW ABC transporter HV036_RS22070 ENOG4105C2J ABC transporter HV036_RS22075 ENOG4108HWW ABC transporter HV036_RS22080 ENOG4105T16 Transcriptional regulator (AraC family) HV036_RS22085 ENOG4108UR8 BAX protein HV036_RS22090 ENOG4107T9C Alpha amylase catalytic region HV036_RS22095 ENOG4105JKW Valine--pyruvate aminotransferase HV036_RS22100 ENOG4108XIB electron transport protein ysaA HV036_RS22110 ENOG4105CT4 transporter HV036_RS22120 ENOG4105C26 Dehydrogenase HV036_RS22125 ENOG41066F8 ROK family HV036_RS22130 ENOG4105EM7 Selenocysteine-specific translation elongation factor HV036_RS22140 ENOG4108U78 Glutathione S-transferase HV036_RS22145 ENOG4105CTS PTS system mannitol-specific HV036_RS22155 ENOG4105E61 Mannitol repressor protein HV036_RS22160 ENOG4108YYI Protein of unknown function (DUF2810) HV036_RS22170 ENOG4105CW0 outer membrane usher protein HV036_RS22175 ENOG4108VCD Chaperone HV036_RS22180 ENOG4108S54 Fimbrial protein HV036_RS22185 ENOG4105DAA L-lactate HV036_RS22190 ENOG41073TP transcriptional regulator HV036_RS22195 ENOG4105DMF Dehydrogenase HV036_RS22200 ENOG4105D2S major facilitator superfamily HV036_RS22205 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HV036_RS22215 ENOG4105EMY transcriptional regulator HV036_RS22220 ENOG4105C7B Threonine dehydratase HV036_RS22230 ENOG4105CM2 brancheD-chain amino acid aminotransferase HV036_RS22235 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HV036_RS22250 ENOG4105C0P Mg chelatase subunit ChlI HV036_RS22255 ENOG4108WFC UPF0438 protein yifE HV036_RS22305 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HV036_RS22310 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HV036_RS22315 ENOG4108Y73 Membrane HV036_RS22320 ENOG4105EJ2 Transcriptional regulator HV036_RS22330 ENOG4105C5Q Transcriptional regulator HV036_RS22335 ENOG4105CH7 arginosuccinase HV036_RS22340 ENOG4105CAS nag kinase HV036_RS22345 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HV036_RS22350 ENOG4105CWC Acetylornithine deacetylase HV036_RS22355 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HV036_RS22360 ENOG4106R3P AraC family transcriptional regulator HV036_RS22370 ENOG4105DCT glycerol dehydrogenase HV036_RS22375 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HV036_RS22380 ENOG4105SYT Methylenetetrahydrofolate reductase HV036_RS22385 ENOG4105CFH Aspartokinase HV036_RS22390 ENOG4105C28 cystathionine HV036_RS22395 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HV036_RS22400 ENOG4105VFB Binds the 23S rRNA (By similarity) HV036_RS22405 ENOG4105C25 Primosomal protein n' HV036_RS22410 ENOG4105ETE Transcriptional regulator (LacI family HV036_RS22415 ENOG41063M6 Cell Division Protein HV036_RS22420 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HV036_RS22425 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HV036_RS22430 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HV036_RS22435 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HV036_RS22440 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HV036_RS22445 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV036_RS22450 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV036_RS22455 ENOG4105CBT Fructose-1,6-bisphosphatase HV036_RS22460 ENOG4105DP0 ferredoxin-NADP reductase HV036_RS22465 ENOG4108VTS Membrane HV036_RS22470 ENOG4105EBK exported protein HV036_RS22475 ENOG4105CP7 Triose-phosphate isomerase HV036_RS22485 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HV036_RS22490 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HV036_RS22495 ENOG4105CTQ phosphohexokinase HV036_RS22500 ENOG41076HS cation diffusion facilitator family transporter HV036_RS22505 ENOG4105FMW periplasmic HV036_RS22510 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV036_RS22515 ENOG4105E0F Histidine kinase HV036_RS22520 ENOG4108RPX mosc domain containing protein HV036_RS22525 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV036_RS22530 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HV036_RS22535 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HV036_RS22540 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HV036_RS22545 ENOG4105DET Rhamnulokinase HV036_RS22550 ENOG4105DKG l-rhamnose isomerase HV036_RS22555 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HV036_RS22560 ENOG4105D4B ABC, transporter HV036_RS22565 ENOG4105C2J ABC transporter HV036_RS22570 ENOG4105CNN ABC, transporter HV036_RS22575 ENOG4105F5R ABC transporter HV036_RS22580 ENOG4105C0A alcohol dehydrogenase HV036_RS22585 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HV036_RS22590 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV036_RS22610 ENOG4108UMN azlc family HV036_RS22635 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV036_RS22640 ENOG4108MG3 formate dehydrogenase HV036_RS22655 ENOG41068KX affects formate dehydrogenase-N HV036_RS22665 ENOG4105SUU thioesterase domain HV036_RS22670 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HV036_RS22675 ENOG4107S2Z UPF0761 membrane protein HV036_RS22680 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HV036_RS22685 ENOG4105E98 transcriptional regulator DeoR family HV036_RS22690 ENOG4108MGF sugar kinase HV036_RS22695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV036_RS22700 ENOG4105D2M Aldolase HV036_RS22705 ENOG4107QKS N-acylglucosamine 2-epimerase HV036_RS22710 ENOG4105CJQ hydrolase, family 31 HV036_RS22715 ENOG4105CT4 transporter HV036_RS22720 ENOG4105CT4 transporter HV036_RS22725 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HV036_RS22730 ENOG4105CI3 gtp-binding protein typa HV036_RS22735 ENOG4105C5F glutamine synthetase HV036_RS22740 ENOG4105CUX Signal transduction histidine kinase HV036_RS22745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV036_RS22750 ENOG4106FIY HV036_RS22755 ENOG4105D4P Coproporphyrinogen iii oxidase HV036_RS22760 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HV036_RS22770 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HV036_RS22775 ENOG4105C2M dna polymerase I HV036_RS22780 ENOG4106HNH Acyl-transferase HV036_RS22785 ENOG4108Z33 Thiol disulfide Interchange Protein HV036_RS22790 ENOG4105E27 serine threonine protein kinase HV036_RS22795 ENOG4105PC1 Conserved Protein HV036_RS22800 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HV036_RS22805 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HV036_RS22830 ENOG4107EJG GntR family transcriptional regulator HV036_RS22835 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV036_RS22840 ENOG4105ETE Transcriptional regulator (LacI family HV036_RS22845 ENOG4108RVA ribokinase HV036_RS22850 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV036_RS22855 ENOG4105CNN ABC, transporter HV036_RS22860 ENOG4105C2J ABC transporter HV036_RS22865 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HV036_RS22870 ENOG4105DFH Transport of potassium into the cell (By similarity) HV036_RS22880 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HV036_RS22885 ENOG4105CU9 asparagine synthetase A HV036_RS22890 ENOG4108VVK transcriptional Regulator, AsnC HV036_RS22895 ENOG4105QTB Flavodoxin HV036_RS22900 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HV036_RS22905 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HV036_RS22910 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HV036_RS22915 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HV036_RS22925 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HV036_RS22930 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HV036_RS22935 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HV036_RS22945 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HV036_RS22950 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HV036_RS22955 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HV036_RS22960 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HV036_RS22965 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HV036_RS22970 ENOG4105C8U phosphate abc transporter HV036_RS22975 ENOG4105E2Z phosphate ABC transporter (Permease HV036_RS22980 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HV036_RS22990 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HV036_RS22995 ENOG4105C7N Xanthine uracil vitamin C permease HV036_RS23000 ENOG4108YYH Nadph-dependent fmn reductase HV036_RS23005 ENOG4105E8Q phosphopantetheinyl transferase HV036_RS23010 ENOG4105G2Y Transcriptional regulator HV036_RS23015 ENOG4105CNH Multidrug resistance protein MdtL HV036_RS23020 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HV036_RS23025 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HV036_RS23035 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HV036_RS23040 ENOG4105VG0 50S ribosomal protein l34 HV036_RS23085 ENOG4105GR3 Histidine kinase HV036_RS23090 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV036_RS23095 ENOG4108PG2 copper resistance HV036_RS23100 ENOG4105JDN Copper resistance protein HV036_RS23125 ENOG4107ZXU DSBA oxidoreductase HV036_RS23130 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV036_RS23195 ENOG4105C94 Transporter HV036_RS23240 ENOG4108T1W Fimbrial subunit type 3 HV036_RS23260 ENOG4106JVB Replication Protein HV036_RS23275 ENOG4108YXQ IS66 Orf2 family protein HV036_RS23305 ENOG4105F2I Transposase HV036_RS23310 ENOG4105DJV ribulose-phosphate 3-epimerase HV036_RS23315 ENOG4108YZG isomerase HV036_RS23325 ENOG4105NYY transcriptional regulator, RpiR HV036_RS23425 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HV036_RS23430 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HV036_RS23445 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HV036_RS23465 ENOG4105CNN ABC, transporter HV036_RS23475 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV036_RS23480 ENOG4105ETE Transcriptional regulator (LacI family HV036_RS23485 ENOG4105F2I Transposase HV036_RS23515 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HV036_RS23530 ENOG41066T8 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity) HV036_RS23535 ENOG4105VEQ Cold shock protein HV036_RS23575 ENOG4105F04 LysR family Transcriptional regulator HV036_RS23590 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HV036_RS23595 ENOG4105CYM Glutathione S-transferase HV036_RS23600 ENOG4105EQR Transposase IS116 IS110 IS902 HV036_RS23615 ENOG4108BUD transposase HV036_RS23680 ENOG4108C33 Resolvase HV036_RS23685 ENOG4105EQR Transposase IS116 IS110 IS902 HV036_RS23700 ENOG4105D13 transposase HV036_RS23730 ENOG4105EQR Transposase IS116 IS110 IS902 HV036_RS23750 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV036_RS23760 ENOG4105ETE Transcriptional regulator (LacI family HV036_RS23765 ENOG4105CIS alcohol dehydrogenase HV036_RS23775 ENOG4105EQR Transposase IS116 IS110 IS902 HV036_RS23790 ENOG4108YXQ IS66 Orf2 family protein HV036_RS23795 ENOG4105E0A ABC, transporter HV036_RS23800 ENOG4108IHU transport system permease protein HV036_RS23805 ENOG4105DQ5 transport system permease protein HV036_RS23810 ENOG4108HUF Transporter HV036_RS23815 ENOG4105GAV receptor HV036_RS23820 ENOG4108S3W Anti-feci sigma factor, fecr HV036_RS23825 ENOG4108SF5 RNA Polymerase HV036_RS23845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV036_RS23870 ENOG4108M24 von Willebrand factor, type A HV036_RS23875 ENOG4108M24 von Willebrand factor, type A HV036_RS23905 ENOG4105DAX Pfam:DUF2983 HV036_RS23985 ENOG4105YJD HV036_RS23990 ENOG41090KG Inner membrane protein YqjE HV036_RS23995 ENOG4105NE1 Conserved Protein HV036_RS24000 ENOG4105WAY exported protein HV036_RS24005 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HV036_RS24010 ENOG4106W5V Membrane HV036_RS24015 ENOG4107YCY Transcriptional regulator HV036_RS24020 ENOG4105DPW Major facilitator superfamily MFS_1 HV036_RS24030 ENOG4105CTX dehydratase HV036_RS24040 ENOG4105DU1 integral membrane protein, terc HV036_RS24045 ENOG4105EE0 oxidoreductase HV036_RS24050 ENOG4108VKG metal-dependent hydrolase HV036_RS24055 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV036_RS24060 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV036_RS24065 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HV036_RS24070 ENOG4105DKT Transcriptional regulator HV036_RS24075 ENOG4105C2J ABC transporter HV036_RS24080 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HV036_RS24085 ENOG4105F5R ABC transporter HV036_RS24090 ENOG4105D4B ABC, transporter HV036_RS24095 ENOG41061GT Aldolase HV036_RS24100 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HV036_RS24105 ENOG4105C8Y Acetylornithine aminotransferase HV036_RS24110 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HV036_RS24115 ENOG4105C8Q Methyl-accepting chemotaxis HV036_RS24120 ENOG4105NTW Transcriptional regulator HV036_RS24125 ENOG4105Q26 Siderophore-interacting protein HV036_RS24165 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV036_RS24200 ENOG4105KSC Transcriptional regulator, TraR DksA family HV036_RS24205 ENOG4105VZ1 Replication Protein HV036_RS24220 ENOG4105ED4 portal protein HV036_RS24320 ENOG4105UZW Tail fiber assembly protein HV036_RS24330 ENOG4105C44 Serine transporter HV036_RS24340 ENOG4108CNN domain protein HV036_RS24345 ENOG4105CWB LysR family transcriptional Regulator HV036_RS24350 ENOG4105KAF membrAne HV036_RS24355 ENOG4105CHF Glutathione S-transferase HV036_RS24370 ENOG4105M5B (LipO)protein