locus-tag	class	description
HV036_RS00010	COG0592	DNA-directed DNA polymerase activity
HV036_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HV036_RS00035	COG0583	DNA-binding transcription factor activity
HV036_RS00045	COG0561	phosphatase activity
HV036_RS00050	COG2186	Transcriptional regulator
HV036_RS00055	COG3734	2-keto-3-deoxy-galactonokinase
HV036_RS00060	COG0800	Aldolase
HV036_RS00065	COG4948	Mandelate Racemase Muconate Lactonizing
HV036_RS00070	COG2271	Major facilitator Superfamily
HV036_RS00075	COG0823	Involved in the tonB-independent uptake of proteins
HV036_RS00080	COG5645	(Lipo)protein
HV036_RS00090	COG0071	Belongs to the small heat shock protein (HSP20) family
HV036_RS00095	COG2985	domain, Protein
HV036_RS00100	COG2188	Transcriptional regulator
HV036_RS00115	COG2149	membrane
HV036_RS00135	COG2814	Major facilitator Superfamily
HV036_RS00155	COG4680	protein conserved in bacteria
HV036_RS00160	COG5499	transcription regulator containing HTH domain
HV036_RS00170	COG0028	Belongs to the TPP enzyme family
HV036_RS00175	COG0440	acetolactate synthase activity
HV036_RS00180	COG2197	response regulator
HV036_RS00200	COG0596	Alpha beta hydrolase
HV036_RS00215	COG0697	spore germination
HV036_RS00220	COG4580	involved in the transport of maltose and maltodextrins
HV036_RS00225	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV036_RS00230	COG2723	6-phospho-beta-galactosidase activity
HV036_RS00235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV036_RS00235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV036_RS00245	COG1609	Transcriptional regulator
HV036_RS00260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV036_RS00265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS00275	COG0454	-acetyltransferase
HV036_RS00280	COG1309	transcriptional regulator
HV036_RS00290	COG1464	Belongs to the NlpA lipoprotein family
HV036_RS00315	COG3188	usher protein
HV036_RS00320	COG3121	Chaperone
HV036_RS00350	COG3188	usher protein
HV036_RS00375	COG2274	protein secretion by the type I secretion system
HV036_RS00390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HV036_RS00395	COG4977	sequence-specific DNA binding
HV036_RS00405	COG3272	Protein of unknown function (DUF1722)
HV036_RS00410	COG2351	hydroxyisourate hydrolase activity
HV036_RS00415	COG0789	Transcriptional regulator
HV036_RS00440	COG3121	Chaperone
HV036_RS00495	COG2211	Major facilitator Superfamily
HV036_RS00500	COG1501	Belongs to the glycosyl hydrolase 31 family
HV036_RS00505	COG2982	Protein involved in outer membrane biogenesis
HV036_RS00510	COG2233	PERMEase
HV036_RS00515	COG0786	glutamate:sodium symporter activity
HV036_RS00520	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV036_RS00525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV036_RS00530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV036_RS00545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HV036_RS00550	COG2860	membrane
HV036_RS00555	COG1561	YicC-like family, N-terminal region
HV036_RS00565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HV036_RS00575	COG0756	dUTP diphosphatase activity
HV036_RS00580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV036_RS00585	COG2003	Belongs to the UPF0758 family
HV036_RS00590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HV036_RS00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV036_RS00600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HV036_RS00605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HV036_RS00615	COG1519	Transferase
HV036_RS00620	COG1216	Glycosyl transferase, family 2
HV036_RS00625	COG0438	transferase activity, transferring glycosyl groups
HV036_RS00635	COG0859	PFAM glycosyl transferase family 9
HV036_RS00660	COG0859	PFAM glycosyl transferase family 9
HV036_RS00665	COG0859	PFAM glycosyl transferase family 9
HV036_RS00680	COG1063	alcohol dehydrogenase
HV036_RS00695	COG0463	Glycosyl transferase, family 2
HV036_RS00700	COG2861	carbohydrate metabolic process
HV036_RS00705	COG4942	peptidase
HV036_RS00710	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HV036_RS00715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV036_RS00720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV036_RS00725	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HV036_RS00730	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HV036_RS00740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV036_RS00750	COG0248	Ppx GppA phosphatase
HV036_RS00760	COG3118	belongs to the thioredoxin family
HV036_RS00765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV036_RS00770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV036_RS00780	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HV036_RS00785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV036_RS00790	COG0456	acetyltransferase
HV036_RS00795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV036_RS00800	COG2244	polysaccharide biosynthetic process
HV036_RS00815	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HV036_RS00845	COG3071	HemY protein
HV036_RS00850	COG2959	enzyme of heme biosynthesis
HV036_RS00860	COG0181	hydroxymethylbilane synthase activity
HV036_RS00875	COG5567	small periplasmic lipoprotein
HV036_RS00895	COG1011	Hydrolase
HV036_RS00900	COG0210	DNA helicase
HV036_RS00920	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HV036_RS00930	COG1280	lysine exporter protein (LysE YggA)
HV036_RS00935	COG1280	lysine exporter protein (LysE YggA)
HV036_RS00940	COG2267	carboxylic ester hydrolase activity
HV036_RS00945	COG0561	phosphatase activity
HV036_RS00950	COG0697	spore germination
HV036_RS00955	COG0583	DNA-binding transcription factor activity
HV036_RS00965	COG0412	Dienelactone hydrolase
HV036_RS00975	COG1322	Protein conserved in bacteria
HV036_RS00980	COG2226	methyltransferase
HV036_RS00985	COG3165	ubiquinone biosynthetic process from chorismate
HV036_RS00990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HV036_RS01005	COG0805	protein transport
HV036_RS01010	COG0084	hydrolase, TatD family'
HV036_RS01020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV036_RS01030	COG0488	(ABC) transporter
HV036_RS01035	COG2944	sequence-specific DNA binding
HV036_RS01045	COG1278	Cold shock
HV036_RS01050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV036_RS01060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV036_RS01070	COG1609	Transcriptional regulator
HV036_RS01075	COG2885	chlorophyll binding
HV036_RS01080	COG0243	molybdopterin cofactor binding
HV036_RS01085	COG0456	acetyltransferase
HV036_RS01090	COG2818	Glycosylase
HV036_RS01095	COG5571	outer membrane autotransporter
HV036_RS01100	COG2223	nitrite transmembrane transporter activity
HV036_RS01115	COG0747	negative chemotaxis
HV036_RS01120	COG0601	transmembrane transport
HV036_RS01125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV036_RS01130	COG0444	Belongs to the ABC transporter superfamily
HV036_RS01135	COG4608	Belongs to the ABC transporter superfamily
HV036_RS01140	COG1072	(Pantothenic acid kinase))
HV036_RS01175	COG0250	Participates in transcription elongation, termination and antitermination
HV036_RS01220	COG3706	GGDEF domain
HV036_RS01230	COG2022	thiamine diphosphate biosynthetic process
HV036_RS01235	COG2104	thiamine diphosphate biosynthetic process
HV036_RS01240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV036_RS01255	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HV036_RS01265	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HV036_RS01270	COG1515	deoxyribonuclease V activity
HV036_RS01290	COG0151	Belongs to the GarS family
HV036_RS01320	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV036_RS01330	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HV036_RS01360	COG1187	pseudouridine synthase activity
HV036_RS01375	COG0527	aspartate kinase activity
HV036_RS01400	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV036_RS01405	COG3223	Belongs to the PsiE family
HV036_RS01440	COG3161	chorismate lyase activity
HV036_RS01450	COG2937	Belongs to the GPAT DAPAT family
HV036_RS01455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV036_RS01460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV036_RS01465	COG0534	Mate efflux family protein
HV036_RS01470	COG3237	CsbD-like
HV036_RS01475	COG0735	belongs to the Fur family
HV036_RS01490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV036_RS01500	COG0604	alcohol dehydrogenase
HV036_RS01505	COG0305	Participates in initiation and elongation during chromosome replication
HV036_RS01515	COG1448	Aminotransferase
HV036_RS01520	COG3700	Belongs to the class B bacterial acid phosphatase family
HV036_RS01530	COG2315	Protein conserved in bacteria
HV036_RS01540	COG0629	single-stranded DNA binding
HV036_RS01570	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HV036_RS01590	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV036_RS01610	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV036_RS01620	COG0789	Transcriptional regulator
HV036_RS01625	COG0625	glutathione transferase activity
HV036_RS01630	COG2252	PERMEase
HV036_RS01635	COG0025	NhaP-type Na H and K H
HV036_RS01640	COG0583	DNA-binding transcription factor activity
HV036_RS01650	COG1346	cytolysis
HV036_RS01655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV036_RS01660	COG3162	membrane
HV036_RS01670	COG1301	dicarboxylic acid transport
HV036_RS01675	COG3415	Transposase
HV036_RS01675	COG2801	Transposase and inactivated derivatives
HV036_RS01680	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV036_RS01700	COG0745	RESPONSE REGULATOR receiver
HV036_RS01710	COG0191	fructose-bisphosphate aldolase activity
HV036_RS01725	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS01730	COG1129	ABC transporter
HV036_RS01735	COG4191	Histidine kinase
HV036_RS01735	COG0784	Response regulator, receiver
HV036_RS01745	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV036_RS01750	COG0456	acetyltransferase
HV036_RS01755	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HV036_RS01760	COG3454	Phosphonate metabolism
HV036_RS01765	COG4778	phosphonate C-P lyase system protein PhnL
HV036_RS01770	COG4107	phosphonate C-P lyase system protein PhnK
HV036_RS01775	COG3627	carbon phosphorus lyase activity
HV036_RS01780	COG3626	phosphonate metabolism
HV036_RS01785	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV036_RS01790	COG3624	Phosphonate C-P lyase system protein PhnG
HV036_RS01795	COG2188	Transcriptional regulator
HV036_RS01800	COG3639	organic phosphonate transmembrane transporter activity
HV036_RS01805	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV036_RS01815	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV036_RS01820	COG2824	Alkylphosphonate utilization operon protein PhnA
HV036_RS01825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HV036_RS01845	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV036_RS01910	COG2378	regulation of single-species biofilm formation
HV036_RS01915	COG4735	regulation of single-species biofilm formation
HV036_RS01950	COG4974	Belongs to the 'phage' integrase family
HV036_RS01990	COG1309	transcriptional regulator
HV036_RS02005	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV036_RS02010	COG1027	Aspartate ammonia-lyase
HV036_RS02015	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV036_RS02020	COG0531	amino acid
HV036_RS02030	COG0459	protein refolding
HV036_RS02035	COG0700	Nucleoside recognition
HV036_RS02040	COG3366	ferrous iron transmembrane transporter activity
HV036_RS02065	COG5510	response to toxic substance
HV036_RS02090	COG0583	DNA-binding transcription factor activity
HV036_RS02100	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HV036_RS02105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV036_RS02110	COG1053	succinate dehydrogenase
HV036_RS02115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HV036_RS02125	COG1511	domain protein
HV036_RS02125	COG3264	Mechanosensitive ion channel
HV036_RS02160	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV036_RS02165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV036_RS02165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV036_RS02170	COG0802	atpase or kinase
HV036_RS02180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HV036_RS02185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HV036_RS02190	COG1923	regulation of RNA biosynthetic process
HV036_RS02195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV036_RS02200	COG0330	HflC and HflK could
HV036_RS02205	COG0330	HflC and HflK could
HV036_RS02210	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV036_RS02220	COG1959	2 iron, 2 sulfur cluster binding
HV036_RS02225	COG0557	exoribonuclease II activity
HV036_RS02230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV036_RS02235	COG0477	Major facilitator Superfamily
HV036_RS02240	COG1960	acyl-CoA dehydrogenase activity
HV036_RS02255	COG3650	response to hydrogen peroxide
HV036_RS02260	COG1073	alpha beta
HV036_RS02275	COG3037	sugar-specific permease SgaT UlaA
HV036_RS02315	COG2965	DNA replication, synthesis of RNA primer
HV036_RS02320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV036_RS02325	COG0359	binds to the 23S rRNA
HV036_RS02330	COG0697	spore germination
HV036_RS02335	COG3061	Opacity-associated protein A
HV036_RS02340	COG0545	Peptidyl-prolyl cis-trans isomerase
HV036_RS02345	COG1113	amino acid transport
HV036_RS02355	COG0840	transmembrane signaling receptor activity
HV036_RS02360	COG0697	spore germination
HV036_RS02370	COG2205	protein histidine kinase activity
HV036_RS02370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV036_RS02375	COG2197	response regulator
HV036_RS02395	COG0702	epimerase
HV036_RS02400	COG1733	regulation of RNA biosynthetic process
HV036_RS02410	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV036_RS02415	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV036_RS02425	COG1253	flavin adenine dinucleotide binding
HV036_RS02430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV036_RS02435	COG0729	surface antigen
HV036_RS02440	COG2911	Protein conserved in bacteria
HV036_RS02445	COG2105	PFAM AIG2 family protein
HV036_RS02455	COG1879	ABC-type sugar transport system periplasmic component
HV036_RS02460	COG1129	ABC transporter
HV036_RS02465	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS02470	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS02485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV036_RS02490	COG3028	Belongs to the UPF0307 family
HV036_RS02495	COG0312	modulator of DNA gyrase
HV036_RS02530	COG3964	amidohydrolase
HV036_RS02550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS02550	COG3711	transcriptional antiterminator
HV036_RS02555	COG0602	queuosine metabolic process
HV036_RS02565	COG0366	Alpha amylase catalytic
HV036_RS02570	COG1263	PTS System
HV036_RS02570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV036_RS02590	COG1609	Transcriptional regulator
HV036_RS02600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HV036_RS02605	COG3397	chitin binding
HV036_RS02610	COG0251	oxidation-reduction process
HV036_RS02620	COG0540	Belongs to the ATCase OTCase family
HV036_RS02635	COG1438	arginine binding
HV036_RS02640	COG1288	antiporter activity
HV036_RS02660	COG3039	Transposase
HV036_RS02665	COG2731	YhcH YjgK YiaL family protein
HV036_RS02670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV036_RS02675	COG0129	dihydroxy-acid dehydratase activity
HV036_RS02680	COG2211	Major facilitator Superfamily
HV036_RS02685	COG3507	Belongs to the glycosyl hydrolase 43 family
HV036_RS02690	COG1414	Transcriptional regulator
HV036_RS02695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV036_RS02720	COG0582	viral genome integration into host DNA
HV036_RS02800	COG1609	Transcriptional regulator
HV036_RS02810	COG2211	Major facilitator Superfamily
HV036_RS02835	COG1335	isochorismatase
HV036_RS02850	COG2204	response regulator
HV036_RS02855	COG4191	Histidine kinase
HV036_RS02860	COG4566	intracellular signal transduction
HV036_RS02865	COG0740	serine-type endopeptidase activity
HV036_RS02870	COG2850	peptidyl-arginine hydroxylation
HV036_RS02895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV036_RS02900	COG5457	Domain of unknown function (DUF1127)
HV036_RS02910	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV036_RS02925	COG0640	Transcriptional regulator
HV036_RS02945	COG2733	membrane
HV036_RS02955	COG1917	Cupin 2, conserved barrel domain protein
HV036_RS02955	COG2207	Transcriptional regulator
HV036_RS02960	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS02980	COG0523	cobalamin synthesis protein
HV036_RS02985	COG2879	small protein
HV036_RS02990	COG1966	Carbon starvation protein
HV036_RS02995	COG1349	DNA-binding transcription factor activity
HV036_RS03000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV036_RS03005	COG2368	4-hydroxyphenylacetate
HV036_RS03025	COG3971	2-oxopent-4-enoate hydratase activity
HV036_RS03035	COG3384	dioxygenase
HV036_RS03040	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS03045	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV036_RS03050	COG1846	Transcriptional regulator
HV036_RS03055	COG0840	transmembrane signaling receptor activity
HV036_RS03075	COG1484	DNA-dependent DNA replication
HV036_RS03085	COG1764	response to oxidative stress
HV036_RS03090	COG1846	Transcriptional regulator
HV036_RS03095	COG3610	response to peptide
HV036_RS03100	COG2966	Psort location CytoplasmicMembrane, score
HV036_RS03105	COG2197	response regulator
HV036_RS03110	COG2197	response regulator
HV036_RS03115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV036_RS03120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV036_RS03125	COG4114	ferric iron reductase
HV036_RS03130	COG3706	GGDEF domain
HV036_RS03155	COG2813	Specifically methylates the guanine in position
HV036_RS03160	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV036_RS03165	COG0456	acetyltransferase
HV036_RS03170	COG1011	Hydrolase
HV036_RS03175	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HV036_RS03180	COG2823	Periplasmic or secreted lipoprotein
HV036_RS03185	COG5487	UPF0391 membrane protein
HV036_RS03190	COG4667	esterase of the alpha-beta hydrolase superfamily
HV036_RS03195	COG0084	hydrolase, TatD family'
HV036_RS03200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV036_RS03205	COG1328	CTP reductase activity
HV036_RS03215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HV036_RS03235	COG3726	membrane protein affecting hemolysin expression
HV036_RS03240	COG0560	Phosphoserine phosphatase
HV036_RS03265	COG0488	(ABC) transporter
HV036_RS03270	COG0741	lytic transglycosylase activity
HV036_RS03275	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HV036_RS03280	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HV036_RS03285	COG0406	alpha-ribazole phosphatase activity
HV036_RS03290	COG2207	Transcriptional regulator
HV036_RS03290	COG3708	Transcriptional regulator
HV036_RS03295	COG3045	CreA protein
HV036_RS03300	COG0745	RESPONSE REGULATOR receiver
HV036_RS03310	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV036_RS03320	COG0527	aspartate kinase activity
HV036_RS03320	COG0460	homoserine dehydrogenase
HV036_RS03330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV036_RS03345	COG1115	amino acid carrier protein
HV036_RS03355	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV036_RS03360	COG0477	Major facilitator Superfamily
HV036_RS03365	COG1584	GPR1 FUN34 yaaH family protein
HV036_RS03370	COG0443	Heat shock 70 kDa protein
HV036_RS03380	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV036_RS03385	COG0583	DNA-binding transcription factor activity
HV036_RS03390	COG0268	Binds directly to 16S ribosomal RNA
HV036_RS03395	COG0196	riboflavin kinase activity
HV036_RS03410	COG1047	Peptidyl-prolyl cis-trans
HV036_RS03415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HV036_RS03425	COG0505	Belongs to the CarA family
HV036_RS03460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV036_RS03460	COG0475	glutathione-regulated potassium exporter activity
HV036_RS03470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV036_RS03475	COG2967	ApaG domain
HV036_RS03485	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HV036_RS03490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV036_RS03495	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV036_RS03500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV036_RS03505	COG0564	pseudouridine synthase activity
HV036_RS03510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HV036_RS03515	COG0417	DNA replication proofreading
HV036_RS03520	COG0235	Class ii aldolase
HV036_RS03525	COG2160	L-arabinose isomerase activity
HV036_RS03530	COG1069	ribulokinase activity
HV036_RS03540	COG0586	Pfam SNARE associated Golgi protein
HV036_RS03550	COG1178	ABC-type Fe3 transport system permease component
HV036_RS03570	COG2814	Major facilitator Superfamily
HV036_RS03595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV036_RS03610	COG0028	Belongs to the TPP enzyme family
HV036_RS03615	COG0440	acetolactate synthase activity
HV036_RS03620	COG1609	Transcriptional regulator
HV036_RS03625	COG2001	Belongs to the MraZ family
HV036_RS03640	COG0768	penicillin binding
HV036_RS03645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV036_RS03650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV036_RS03655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV036_RS03665	COG0772	Belongs to the SEDS family
HV036_RS03680	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV036_RS03690	COG0849	cell division
HV036_RS03695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV036_RS03700	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HV036_RS03710	COG0653	protein targeting
HV036_RS03715	COG0494	nUDIX hydrolase
HV036_RS03720	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HV036_RS03725	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HV036_RS03735	COG0516	GMP reductase activity
HV036_RS03740	COG1459	type II secretion system
HV036_RS03745	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV036_RS03750	COG4969	Belongs to the N-Me-Phe pilin family
HV036_RS03760	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV036_RS03765	COG3725	Membrane protein required for beta-lactamase induction
HV036_RS03770	COG3940	Belongs to the glycosyl hydrolase 43 family
HV036_RS03775	COG2211	Major facilitator Superfamily
HV036_RS03780	COG1113	amino acid transport
HV036_RS03785	COG2186	Transcriptional regulator
HV036_RS03790	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV036_RS03795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV036_RS03800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV036_RS03810	COG3064	Membrane
HV036_RS03825	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HV036_RS03830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HV036_RS03840	COG2132	Multicopper oxidase
HV036_RS03845	COG4993	Dehydrogenase
HV036_RS03855	COG0288	reversible hydration of carbon dioxide
HV036_RS03860	COG1131	(ABC) transporter
HV036_RS03865	COG0842	Transport permease protein
HV036_RS03870	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS03875	COG0726	polysaccharide deacetylase
HV036_RS03885	COG3539	Fimbrial protein
HV036_RS03895	COG3539	Fimbrial protein
HV036_RS03900	COG3188	usher protein
HV036_RS03905	COG3121	Chaperone
HV036_RS03915	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HV036_RS03920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HV036_RS03930	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV036_RS03935	COG0617	tRNA 3'-terminal CCA addition
HV036_RS03940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV036_RS03950	COG1489	DNA binding
HV036_RS03955	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV036_RS03960	COG1643	Atp-dependent helicase
HV036_RS03965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV036_RS03970	COG4774	siderophore transport
HV036_RS03975	COG1120	ATPase activity
HV036_RS03980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV036_RS03985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV036_RS03990	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HV036_RS04000	COG0316	Belongs to the HesB IscA family
HV036_RS04005	COG2860	membrane
HV036_RS04015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV036_RS04020	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HV036_RS04025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV036_RS04030	COG3835	regulator
HV036_RS04075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV036_RS04085	COG0575	Belongs to the CDS family
HV036_RS04090	COG0750	zinc metalloprotease
HV036_RS04095	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV036_RS04110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HV036_RS04115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV036_RS04120	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV036_RS04125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HV036_RS04135	COG0825	malonyl-CoA metabolic process
HV036_RS04145	COG0346	lactoylglutathione lyase activity
HV036_RS04150	COG0037	tRNA processing
HV036_RS04155	COG4568	rho-dependent transcription termination
HV036_RS04170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV036_RS04175	COG3015	lipoprotein NlpE involved in copper resistance
HV036_RS04185	COG1720	tRNA m6t6A37 methyltransferase activity
HV036_RS04195	COG1464	Belongs to the NlpA lipoprotein family
HV036_RS04200	COG2011	ABC-type metal ion transport system permease component
HV036_RS04210	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV036_RS04250	COG0583	DNA-binding transcription factor activity
HV036_RS04255	COG2814	Major facilitator Superfamily
HV036_RS04260	COG3021	interspecies interaction between organisms
HV036_RS04265	COG2226	methyltransferase
HV036_RS04270	COG0741	lytic transglycosylase activity
HV036_RS04270	COG1388	LysM domain
HV036_RS04275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV036_RS04280	COG2226	methyltransferase
HV036_RS04305	COG0444	Belongs to the ABC transporter superfamily
HV036_RS04310	COG4608	Belongs to the ABC transporter superfamily
HV036_RS04335	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV036_RS04340	COG1960	acyl-CoA dehydrogenase activity
HV036_RS04350	COG0121	glutamine amidotransferase
HV036_RS04355	COG3034	peptidoglycan biosynthetic process
HV036_RS04370	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV036_RS04375	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV036_RS04390	COG2991	Protein conserved in bacteria
HV036_RS04395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV036_RS04400	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV036_RS04420	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV036_RS04425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV036_RS04430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HV036_RS04440	COG0582	viral genome integration into host DNA
HV036_RS04610	COG0463	Glycosyl transferase, family 2
HV036_RS04615	COG2246	polysaccharide biosynthetic process
HV036_RS04625	COG3772	lysozyme
HV036_RS04715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV036_RS04725	COG5001	Diguanylate cyclase
HV036_RS04725	COG3300	MHYT domain
HV036_RS04745	COG0628	permease
HV036_RS04750	COG0833	amino acid
HV036_RS04755	COG2040	homocysteine
HV036_RS04760	COG4521	taurine ABC transporter
HV036_RS04765	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV036_RS04770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV036_RS04775	COG2175	clavaminate synthase activity
HV036_RS04785	COG0113	porphobilinogen synthase activity
HV036_RS04800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV036_RS04805	COG1335	isochorismatase
HV036_RS04810	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV036_RS04830	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV036_RS04855	COG3706	GGDEF domain
HV036_RS04860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV036_RS04865	COG1671	Belongs to the UPF0178 family
HV036_RS04870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV036_RS04880	COG4126	flavin adenine dinucleotide binding
HV036_RS04885	COG3123	guanosine phosphorylase activity
HV036_RS04895	COG1940	carbohydrate kinase activity
HV036_RS04900	COG0419	ATPase involved in DNA repair
HV036_RS04905	COG0420	3'-5' exonuclease activity
HV036_RS04915	COG5002	protein histidine kinase activity
HV036_RS04930	COG0366	Alpha amylase catalytic
HV036_RS04945	COG0450	alkyl hydroperoxide reductase
HV036_RS04950	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HV036_RS04965	COG1862	Preprotein translocase
HV036_RS04970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV036_RS04975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV036_RS04990	COG4238	major outer membrane lipoprotein
HV036_RS04995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HV036_RS05000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV036_RS05000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV036_RS05005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HV036_RS05010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HV036_RS05015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV036_RS05020	COG0667	Aldo Keto reductase
HV036_RS05025	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV036_RS05030	COG0142	geranyltranstransferase activity
HV036_RS05045	COG0693	protein deglycase activity
HV036_RS05060	COG2814	Major facilitator Superfamily
HV036_RS05065	COG0235	Class ii aldolase
HV036_RS05075	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV036_RS05085	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS05090	COG1129	ABC transporter
HV036_RS05110	COG0109	protoheme IX farnesyltransferase activity
HV036_RS05115	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV036_RS05120	COG1845	cytochrome c oxidase, subunit III
HV036_RS05125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV036_RS05130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV036_RS05135	COG2223	nitrite transmembrane transporter activity
HV036_RS05140	COG3056	Lipoprotein
HV036_RS05145	COG0271	Belongs to the BolA IbaG family
HV036_RS05150	COG0544	peptidyl-prolyl cis-trans isomerase activity
HV036_RS05165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV036_RS05170	COG0776	regulation of translation
HV036_RS05175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV036_RS05180	COG1555	photosystem II stabilization
HV036_RS05185	COG0824	Thioesterase
HV036_RS05190	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HV036_RS05195	COG4533	DNA binding
HV036_RS05200	COG0561	phosphatase activity
HV036_RS05210	COG1522	sequence-specific DNA binding
HV036_RS05215	COG1132	(ABC) transporter
HV036_RS05220	COG1132	(ABC) transporter
HV036_RS05225	COG0347	Belongs to the P(II) protein family
HV036_RS05230	COG0004	ammonium transporteR
HV036_RS05235	COG1946	Acyl-CoA thioesterase
HV036_RS05240	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV036_RS05245	COG3695	enzyme binding
HV036_RS05265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV036_RS05270	COG2364	Membrane
HV036_RS05275	COG1609	Transcriptional regulator
HV036_RS05285	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV036_RS05295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HV036_RS05315	COG0110	maltose O-acetyltransferase activity
HV036_RS05330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV036_RS05335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS05340	COG1309	transcriptional regulator
HV036_RS05345	COG3264	Mechanosensitive ion channel
HV036_RS05345	COG1196	nuclear chromosome segregation
HV036_RS05355	COG3923	Primosomal replication protein n
HV036_RS05360	COG2832	Protein of unknown function (DUF454)
HV036_RS05365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HV036_RS05375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HV036_RS05380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HV036_RS05385	COG0326	Molecular chaperone. Has ATPase activity
HV036_RS05395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HV036_RS05400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV036_RS05405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV036_RS05405	COG4651	solute:proton antiporter activity
HV036_RS05410	COG2223	nitrite transmembrane transporter activity
HV036_RS05420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV036_RS05425	COG3735	TraB family
HV036_RS05430	COG2217	Heavy metal translocating P-type atpase
HV036_RS05440	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV036_RS05445	COG0330	HflC and HflK could
HV036_RS05455	COG4619	ABC transporter
HV036_RS05460	COG0390	transport system, permease component
HV036_RS05465	COG3118	belongs to the thioredoxin family
HV036_RS05470	COG0300	oxidoreductase activity
HV036_RS05475	COG2755	lipolytic protein G-D-S-L family
HV036_RS05480	COG4181	ATPase activity
HV036_RS05485	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV036_RS05490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV036_RS05500	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV036_RS05505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV036_RS05510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV036_RS05515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV036_RS05525	COG1988	membrane-bound metal-dependent
HV036_RS05530	COG1609	Transcriptional regulator
HV036_RS05535	COG1263	PTS System
HV036_RS05535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV036_RS05535	COG2190	(PTS) system
HV036_RS05540	COG2501	S4 domain
HV036_RS05610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HV036_RS05630	COG1113	amino acid transport
HV036_RS05635	COG2211	Major facilitator Superfamily
HV036_RS05650	COG1609	Transcriptional regulator
HV036_RS05655	COG0668	transmembrane transport
HV036_RS05660	COG0477	Major facilitator Superfamily
HV036_RS05675	COG0778	Nitroreductase
HV036_RS05680	COG2315	Protein conserved in bacteria
HV036_RS05695	COG2207	Transcriptional regulator
HV036_RS05700	COG4774	siderophore transport
HV036_RS05730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HV036_RS05745	COG3209	COG3209 Rhs family protein
HV036_RS05795	COG4680	protein conserved in bacteria
HV036_RS05810	COG1278	Cold shock
HV036_RS05860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV036_RS05880	COG1121	(ABC) transporter
HV036_RS05885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV036_RS05890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV036_RS05895	COG2977	Belongs to the P-Pant transferase superfamily
HV036_RS05900	COG4771	TonB-dependent receptor
HV036_RS05905	COG2382	esterase
HV036_RS05910	COG3251	PFAM MbtH domain protein
HV036_RS05915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV036_RS05915	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV036_RS05920	COG1120	ATPase activity
HV036_RS05925	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV036_RS05930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV036_RS05940	COG4592	Periplasmic binding protein
HV036_RS05945	COG1169	isochorismate synthase
HV036_RS05950	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV036_RS05955	COG3433	isochorismatase activity
HV036_RS05955	COG1535	isochorismatase
HV036_RS05960	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS05965	COG2050	protein possibly involved in aromatic compounds catabolism
HV036_RS05975	COG0700	Nucleoside recognition
HV036_RS05980	COG3366	ferrous iron transmembrane transporter activity
HV036_RS05985	COG1966	Carbon starvation protein
HV036_RS05990	COG2879	small protein
HV036_RS06010	COG0371	Dehydrogenase
HV036_RS06015	COG1129	ABC transporter
HV036_RS06020	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS06035	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HV036_RS06050	COG3423	Transcriptional regulator
HV036_RS06065	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HV036_RS06070	COG0235	Class ii aldolase
HV036_RS06075	COG0436	Aminotransferase
HV036_RS06080	COG1475	DNA binding
HV036_RS06085	COG3969	phosphoadenosine phosphosulfate
HV036_RS06110	COG1063	alcohol dehydrogenase
HV036_RS06115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV036_RS06125	COG3719	Belongs to the RNase T2 family
HV036_RS06130	COG3069	C4-dicarboxylate transmembrane transporter activity
HV036_RS06150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS06175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV036_RS06180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HV036_RS06185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HV036_RS06190	COG0583	DNA-binding transcription factor activity
HV036_RS06195	COG0321	lipoyl(octanoyl) transferase activity
HV036_RS06205	COG1686	Belongs to the peptidase S11 family
HV036_RS06210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV036_RS06215	COG0772	Belongs to the SEDS family
HV036_RS06220	COG0768	penicillin binding
HV036_RS06230	COG0799	negative regulation of ribosome biogenesis
HV036_RS06240	COG1466	dna polymerase III delta subunit
HV036_RS06255	COG2888	peptidyl-tyrosine sulfation
HV036_RS06260	COG1957	nucleoside hydrolase
HV036_RS06265	COG1126	abc transporter atp-binding protein
HV036_RS06270	COG0765	amino acid transport
HV036_RS06275	COG0765	amino acid transport
HV036_RS06295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV036_RS06300	COG1702	phosphate starvation-inducible protein PhoH
HV036_RS06305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HV036_RS06310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV036_RS06350	COG0367	asparagine synthase
HV036_RS06355	COG0647	UMP catabolic process
HV036_RS06360	COG1940	carbohydrate kinase activity
HV036_RS06360	COG1846	Transcriptional regulator
HV036_RS06365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV036_RS06375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV036_RS06375	COG2190	(PTS) system
HV036_RS06375	COG1263	PTS System
HV036_RS06380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV036_RS06395	COG0735	belongs to the Fur family
HV036_RS06415	COG0596	Alpha beta hydrolase
HV036_RS06420	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV036_RS06425	COG0033	Phosphoglucomutase
HV036_RS06430	COG0531	amino acid
HV036_RS06435	COG1982	Orn Lys Arg decarboxylase major
HV036_RS06445	COG0745	RESPONSE REGULATOR receiver
HV036_RS06450	COG2205	protein histidine kinase activity
HV036_RS06455	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HV036_RS06460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HV036_RS06465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HV036_RS06485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HV036_RS06490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV036_RS06495	COG1984	allophanate hydrolase subunit 2
HV036_RS06505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HV036_RS06510	COG0372	Belongs to the citrate synthase family
HV036_RS06515	COG2009	succinate dehydrogenase
HV036_RS06520	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV036_RS06525	COG1053	succinate dehydrogenase
HV036_RS06530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV036_RS06535	COG0567	Dehydrogenase, E1 component
HV036_RS06540	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV036_RS06545	COG0045	succinate-CoA ligase (ADP-forming) activity
HV036_RS06550	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV036_RS06555	COG2188	Transcriptional regulator
HV036_RS06560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS06560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV036_RS06560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV036_RS06565	COG0383	alpha-mannosidase activity
HV036_RS06570	COG1271	oxidase subunit
HV036_RS06575	COG1294	oxidase, subunit
HV036_RS06580	COG4890	Cyd operon protein YbgT
HV036_RS06585	COG3790	cyd operon protein YbgE
HV036_RS06590	COG0824	Thioesterase
HV036_RS06595	COG0811	peptide transport
HV036_RS06600	COG0848	biopolymer transport protein
HV036_RS06605	COG3064	Membrane
HV036_RS06610	COG0823	Involved in the tonB-independent uptake of proteins
HV036_RS06615	COG2885	chlorophyll binding
HV036_RS06620	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV036_RS06655	COG3201	nicotinamide mononucleotide transporter
HV036_RS06660	COG1230	cation diffusion facilitator family transporter
HV036_RS06670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV036_RS06680	COG2017	converts alpha-aldose to the beta-anomer
HV036_RS06685	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HV036_RS06690	COG1085	galactose-1-phosphate uridylyltransferase
HV036_RS06695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV036_RS06700	COG1119	ATPase activity
HV036_RS06705	COG3585	molybdate ion transport
HV036_RS06705	COG2005	Transcriptional regulator
HV036_RS06715	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV036_RS06720	COG4149	molybdate abc transporter
HV036_RS06730	COG0561	phosphatase activity
HV036_RS06735	COG2706	6-phosphogluconolactonase activity
HV036_RS06740	COG4677	pectinesterase activity
HV036_RS06750	COG0010	Belongs to the arginase family
HV036_RS06760	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HV036_RS06765	COG2986	histidine ammonia-lyase
HV036_RS06770	COG1881	PFAM PEBP family protein
HV036_RS06775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HV036_RS06780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HV036_RS06785	COG0156	8-amino-7-oxononanoate synthase activity
HV036_RS06790	COG2226	methyltransferase
HV036_RS06820	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV036_RS06825	COG0315	cyclic pyranopterin monophosphate synthase activity
HV036_RS06830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV036_RS06835	COG0314	molybdopterin synthase activity
HV036_RS06840	COG0670	Belongs to the BI1 family
HV036_RS06845	COG0392	lysyltransferase activity
HV036_RS06850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV036_RS06855	COG3568	Endonuclease Exonuclease Phosphatase
HV036_RS06865	COG0842	Transport permease protein
HV036_RS06870	COG0842	Transport permease protein
HV036_RS06875	COG1131	(ABC) transporter
HV036_RS06880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS06885	COG1309	transcriptional regulator
HV036_RS06890	COG0513	Belongs to the DEAD box helicase family
HV036_RS06920	COG3539	Fimbrial protein
HV036_RS06925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV036_RS06935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV036_RS06945	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HV036_RS06950	COG0668	transmembrane transport
HV036_RS06955	COG1126	abc transporter atp-binding protein
HV036_RS06960	COG0765	amino acid transport
HV036_RS06965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV036_RS06970	COG0783	Belongs to the Dps family
HV036_RS06980	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV036_RS06985	COG2194	sulfuric ester hydrolase activity
HV036_RS06995	COG1321	iron dependent repressor
HV036_RS07000	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV036_RS07005	COG1566	PFAM secretion protein HlyD family protein
HV036_RS07010	COG2814	Major facilitator Superfamily
HV036_RS07020	COG0667	Aldo Keto reductase
HV036_RS07025	COG2723	6-phospho-beta-galactosidase activity
HV036_RS07030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV036_RS07035	COG2188	Transcriptional regulator
HV036_RS07040	COG1376	ErfK ybiS ycfS ynhG family protein
HV036_RS07045	COG0488	(ABC) transporter
HV036_RS07055	COG2271	Major facilitator Superfamily
HV036_RS07060	COG1609	Transcriptional regulator
HV036_RS07070	COG0561	phosphatase activity
HV036_RS07075	COG1882	Formate acetyltransferase
HV036_RS07080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV036_RS07085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV036_RS07095	COG0303	'Molybdopterin
HV036_RS07100	COG1446	asparaginase
HV036_RS07135	COG2133	pyrroloquinoline quinone binding
HV036_RS07140	COG0625	glutathione transferase activity
HV036_RS07145	COG1686	Belongs to the peptidase S11 family
HV036_RS07150	COG1349	DNA-binding transcription factor activity
HV036_RS07155	COG0671	phosphoesterase, PA-phosphatase related
HV036_RS07165	COG2814	Major facilitator Superfamily
HV036_RS07170	COG0561	phosphatase activity
HV036_RS07175	COG0738	Major facilitator superfamily
HV036_RS07180	COG3226	Transcriptional regulator
HV036_RS07185	COG1393	Belongs to the ArsC family
HV036_RS07195	COG0640	Transcriptional regulator
HV036_RS07240	COG0778	Nitroreductase
HV036_RS07255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV036_RS07260	COG3842	ATPase activity
HV036_RS07265	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV036_RS07270	COG1177	transmembrane transport
HV036_RS07280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV036_RS07285	COG0745	RESPONSE REGULATOR receiver
HV036_RS07290	COG5002	protein histidine kinase activity
HV036_RS07295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV036_RS07300	COG4160	amino acid transport
HV036_RS07305	COG4215	(ABC) transporter
HV036_RS07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV036_RS07315	COG1126	abc transporter atp-binding protein
HV036_RS07325	COG0393	Putative heavy-metal-binding
HV036_RS07330	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV036_RS07350	COG3031	protein transport across the cell outer membrane
HV036_RS07355	COG1450	Type ii and iii secretion system protein
HV036_RS07360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV036_RS07365	COG1459	type II secretion system
HV036_RS07370	COG2165	general secretion pathway protein
HV036_RS07380	COG2165	general secretion pathway protein
HV036_RS07405	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HV036_RS07420	COG3397	chitin binding
HV036_RS07425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV036_RS07430	COG0702	epimerase
HV036_RS07435	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV036_RS07440	COG0028	Belongs to the TPP enzyme family
HV036_RS07445	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV036_RS07450	COG1151	hydroxylamine reductase activity
HV036_RS07455	COG2431	L-lysine efflux transmembrane transporter activity
HV036_RS07465	COG3593	DNA synthesis involved in DNA repair
HV036_RS07470	COG2990	Protein conserved in bacteria
HV036_RS07475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS07485	COG1278	Cold shock
HV036_RS07490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HV036_RS07495	COG0542	response to heat
HV036_RS07505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV036_RS07510	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HV036_RS07515	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV036_RS07520	COG4988	ABC transporter
HV036_RS07525	COG0492	ferredoxin-NADP+ reductase activity
HV036_RS07535	COG1178	ABC-type Fe3 transport system permease component
HV036_RS07535	COG1674	ftsk spoiiie
HV036_RS07540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HV036_RS07545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV036_RS07550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HV036_RS07555	COG0243	molybdopterin cofactor binding
HV036_RS07560	COG0437	4 iron, 4 sulfur cluster binding
HV036_RS07565	COG3302	dmso reductase anchor subunit
HV036_RS07570	COG0477	Major facilitator Superfamily
HV036_RS07580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV036_RS07585	COG1882	Formate acetyltransferase
HV036_RS07590	COG2116	formate transmembrane transporter activity
HV036_RS07595	COG1944	ATP diphosphatase activity
HV036_RS07600	COG2323	membrane
HV036_RS07605	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HV036_RS07610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HV036_RS07615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HV036_RS07620	COG0539	negative regulation of cytoplasmic translation
HV036_RS07625	COG0776	regulation of translation
HV036_RS07630	COG2333	competence protein COMEC
HV036_RS07630	COG0658	competence protein
HV036_RS07635	COG1132	(ABC) transporter
HV036_RS07645	COG3214	Protein conserved in bacteria
HV036_RS07650	COG2835	tetraacyldisaccharide 4'-kinase activity
HV036_RS07655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HV036_RS07660	COG3173	Aminoglycoside phosphotransferase
HV036_RS07665	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV036_RS07670	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV036_RS07680	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV036_RS07685	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV036_RS07690	COG2989	Protein conserved in bacteria
HV036_RS07695	COG3108	Peptidase M15
HV036_RS07700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV036_RS07705	COG1448	Aminotransferase
HV036_RS07715	COG0017	Asparaginyl-tRNA synthetase
HV036_RS07720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HV036_RS07725	COG0308	aminopeptidase N
HV036_RS07735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV036_RS07740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV036_RS07745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV036_RS07750	COG0431	NADPH-dependent FMN reductase
HV036_RS07755	COG0167	dihydroorotate dehydrogenase activity
HV036_RS07765	COG3217	Mosc domain protein beta barrel domain protein
HV036_RS07765	COG0633	Ferredoxin
HV036_RS07770	COG0116	Belongs to the methyltransferase superfamily
HV036_RS07770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HV036_RS07775	COG0488	(ABC) transporter
HV036_RS07780	COG2995	paraquat-inducible protein a
HV036_RS07785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV036_RS07785	COG3008	intermembrane lipid transfer
HV036_RS07790	COG3009	Protein conserved in bacteria
HV036_RS07795	COG3130	regulation of translation
HV036_RS07805	COG1067	ATP-dependent peptidase activity
HV036_RS07810	COG3120	sequence-specific DNA binding
HV036_RS07820	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HV036_RS07825	COG3070	regulator of competence-specific genes
HV036_RS07830	COG1289	transmembrane transporter activity
HV036_RS07835	COG3304	Inner membrane component domain
HV036_RS07840	COG0210	DNA helicase
HV036_RS07845	COG1803	Methylglyoxal synthase
HV036_RS07850	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HV036_RS07855	COG1832	CoA-binding protein
HV036_RS07865	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HV036_RS07870	COG1254	Belongs to the acylphosphatase family
HV036_RS07880	COG0670	Belongs to the BI1 family
HV036_RS07900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV036_RS07910	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV036_RS07910	COG3264	Mechanosensitive ion channel
HV036_RS07930	COG2239	Acts as a magnesium transporter
HV036_RS07935	COG0586	Pfam SNARE associated Golgi protein
HV036_RS07955	COG3729	General stress protein
HV036_RS07965	COG2233	PERMEase
HV036_RS07970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV036_RS07975	COG0778	Nitroreductase
HV036_RS07980	COG2267	carboxylic ester hydrolase activity
HV036_RS07985	COG0251	oxidation-reduction process
HV036_RS07990	COG1335	isochorismatase
HV036_RS07995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV036_RS08000	COG1309	transcriptional regulator
HV036_RS08010	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV036_RS08010	COG0506	proline dehydrogenase activity
HV036_RS08010	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV036_RS08015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV036_RS08025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV036_RS08045	COG1702	phosphate starvation-inducible protein PhoH
HV036_RS08050	COG1115	amino acid carrier protein
HV036_RS08065	COG1335	isochorismatase
HV036_RS08095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV036_RS08100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HV036_RS08105	COG3381	protein complex oligomerization
HV036_RS08155	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV036_RS08170	COG2943	transferase activity, transferring hexosyl groups
HV036_RS08175	COG5645	(Lipo)protein
HV036_RS08190	COG1560	Kdo2-lipid A biosynthetic process
HV036_RS08200	COG2353	YceI-like domain
HV036_RS08205	COG3038	cytochrome b561
HV036_RS08230	COG0418	dihydroorotase activity
HV036_RS08240	COG0477	Major facilitator Superfamily
HV036_RS08245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV036_RS08250	COG3132	Protein of unknown function, DUF480
HV036_RS08285	COG1558	bacterial-type flagellum-dependent cell motility
HV036_RS08295	COG1749	Flagellar hook protein flgE
HV036_RS08305	COG4786	Flagellar basal body rod
HV036_RS08325	COG1256	bacterial-type flagellum assembly
HV036_RS08335	COG2814	Major facilitator Superfamily
HV036_RS08340	COG0583	DNA-binding transcription factor activity
HV036_RS08345	COG1530	ribonuclease E activity
HV036_RS08350	COG0564	pseudouridine synthase activity
HV036_RS08355	COG0424	maF-like protein
HV036_RS08365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HV036_RS08370	COG0416	fatty acid biosynthetic process
HV036_RS08375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HV036_RS08390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV036_RS08395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV036_RS08400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV036_RS08405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV036_RS08415	COG0470	DNA polymerase III
HV036_RS08420	COG0084	hydrolase, TatD family'
HV036_RS08430	COG4773	Receptor
HV036_RS08435	COG0537	adenosine 5'-monophosphoramidase activity
HV036_RS08440	COG5633	Lipoprotein
HV036_RS08445	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HV036_RS08460	COG3150	esterase
HV036_RS08465	COG1252	NADH dehydrogenase
HV036_RS08470	COG3134	Outer membrane lipoprotein
HV036_RS08475	COG1309	transcriptional regulator
HV036_RS08485	COG1388	LysM domain
HV036_RS08485	COG1376	ErfK ybiS ycfS ynhG family protein
HV036_RS08490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV036_RS08495	COG4763	Acyl-transferase
HV036_RS08500	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV036_RS08505	COG1136	(ABC) transporter
HV036_RS08510	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV036_RS08550	COG1943	Transposase
HV036_RS08555	COG2850	peptidyl-arginine hydroxylation
HV036_RS08560	COG2205	protein histidine kinase activity
HV036_RS08575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV036_RS08580	COG2915	High frequency lysogenization protein hflD homolog
HV036_RS08595	COG1187	pseudouridine synthase activity
HV036_RS08600	COG0538	isocitrate dehydrogenase activity
HV036_RS08620	COG2261	transglycosylase associated protein
HV036_RS08635	COG2203	Gaf domain
HV036_RS08635	COG2199	diguanylate cyclase activity
HV036_RS08640	COG3042	response to heat
HV036_RS08650	COG3189	MarR family transcriptional regulator
HV036_RS08655	COG0504	CTP synthase activity
HV036_RS08660	COG2807	transmembrane transport
HV036_RS08665	COG2207	Transcriptional regulator
HV036_RS08670	COG2707	UPF0756 membrane protein
HV036_RS08680	COG2211	Major facilitator Superfamily
HV036_RS08685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV036_RS08690	COG2718	Belongs to the UPF0229 family
HV036_RS08695	COG2766	serine protein kinase
HV036_RS08700	COG3713	MltA-interacting MipA family protein
HV036_RS08720	COG3139	Protein of unknown function (DUF1315)
HV036_RS08730	COG1335	isochorismatase
HV036_RS08735	COG0252	asparaginase activity
HV036_RS08740	COG0616	signal peptide processing
HV036_RS08745	COG0778	Nitroreductase
HV036_RS08750	COG0709	Synthesizes selenophosphate from selenide and ATP
HV036_RS08755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV036_RS08770	COG0494	nUDIX hydrolase
HV036_RS08775	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV036_RS08780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV036_RS08785	COG2897	thiosulfate sulfurtransferase activity
HV036_RS08790	COG4136	ATPase activity
HV036_RS08795	COG4135	transport system, permease component
HV036_RS08800	COG4134	Bacterial extracellular solute-binding protein
HV036_RS08820	COG3138	arginine N-succinyltransferase
HV036_RS08825	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS08830	COG3724	N-succinylarginine dihydrolase activity
HV036_RS08840	COG3678	ATP-independent chaperone mediated protein folding
HV036_RS08850	COG0322	excinuclease ABC activity
HV036_RS08855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HV036_RS08860	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV036_RS08865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV036_RS08870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV036_RS08875	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV036_RS08880	COG2169	Transcriptional regulator
HV036_RS08880	COG1917	Cupin 2, conserved barrel domain protein
HV036_RS08885	COG1486	melibiose metabolic process
HV036_RS08890	COG3394	polysaccharide catabolic process
HV036_RS08895	COG0753	catalase activity
HV036_RS08910	COG1988	membrane-bound metal-dependent
HV036_RS08915	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS08920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV036_RS08930	COG3001	Fructosamine kinase
HV036_RS08940	COG1105	Belongs to the carbohydrate kinase PfkB family
HV036_RS08950	COG3137	Salt-induced outer membrane protein
HV036_RS08995	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HV036_RS09000	COG0072	phenylalanine-tRNA ligase activity
HV036_RS09000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV036_RS09005	COG0776	regulation of translation
HV036_RS09015	COG0386	Belongs to the glutathione peroxidase family
HV036_RS09025	COG0791	NLP P60 protein
HV036_RS09035	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HV036_RS09045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV036_RS09050	COG4558	Periplasmic binding protein
HV036_RS09055	COG3720	iron ion transport
HV036_RS09065	COG4256	Hemin uptake protein
HV036_RS09070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV036_RS09075	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HV036_RS09080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV036_RS09080	COG0574	Belongs to the PEP-utilizing enzyme family
HV036_RS09085	COG2211	Major facilitator Superfamily
HV036_RS09090	COG1472	Belongs to the glycosyl hydrolase 3 family
HV036_RS09105	COG0628	permease
HV036_RS09110	COG0277	FAD linked oxidase domain protein
HV036_RS09110	COG0247	lactate metabolic process
HV036_RS09115	COG2050	protein possibly involved in aromatic compounds catabolism
HV036_RS09125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV036_RS09165	COG3383	formate dehydrogenase (NAD+) activity
HV036_RS09185	COG2200	EAL domain
HV036_RS09190	COG0789	Transcriptional regulator
HV036_RS09205	COG0316	Belongs to the HesB IscA family
HV036_RS09210	COG0719	Fe-S assembly protein
HV036_RS09215	COG0396	ATPase activity
HV036_RS09220	COG0719	Fe-S assembly protein
HV036_RS09225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV036_RS09230	COG2166	iron-sulfur cluster assembly
HV036_RS09235	COG1376	ErfK ybiS ycfS ynhG family protein
HV036_RS09250	COG0626	cystathionine gamma-synthase activity
HV036_RS09265	COG2011	ABC-type metal ion transport system permease component
HV036_RS09270	COG1464	Belongs to the NlpA lipoprotein family
HV036_RS09290	COG4191	Histidine kinase
HV036_RS09310	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV036_RS09320	COG4529	Protein conserved in bacteria
HV036_RS09335	COG0534	Mate efflux family protein
HV036_RS09340	COG0307	riboflavin synthase, alpha
HV036_RS09345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV036_RS09350	COG2814	Major facilitator Superfamily
HV036_RS09355	COG0583	DNA-binding transcription factor activity
HV036_RS09370	COG2814	Major facilitator Superfamily
HV036_RS09380	COG0791	NLP P60 protein
HV036_RS09385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV036_RS09395	COG0346	lactoylglutathione lyase activity
HV036_RS09400	COG1902	pentaerythritol trinitrate reductase activity
HV036_RS09405	COG1309	transcriptional regulator
HV036_RS09410	COG2194	sulfuric ester hydrolase activity
HV036_RS09415	COG3313	Fe-S protein
HV036_RS09420	COG4989	oxidoreductase activity
HV036_RS09425	COG2032	superoxide dismutase activity
HV036_RS09430	COG1289	transmembrane transporter activity
HV036_RS09435	COG1566	PFAM secretion protein HlyD family protein
HV036_RS09450	COG3706	GGDEF domain
HV036_RS09460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HV036_RS09465	COG3895	Periplasmic Protein
HV036_RS09470	COG0259	pyridoxamine-phosphate oxidase activity
HV036_RS09475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HV036_RS09480	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV036_RS09485	COG0625	glutathione transferase activity
HV036_RS09490	COG3104	oligopeptide transport
HV036_RS09495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV036_RS09545	COG0673	inositol 2-dehydrogenase activity
HV036_RS09550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HV036_RS09555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV036_RS09565	COG0582	viral genome integration into host DNA
HV036_RS09800	COG1783	phage Terminase large subunit
HV036_RS09965	COG1609	Transcriptional regulator
HV036_RS09970	COG5339	Protein conserved in bacteria
HV036_RS09980	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV036_RS09980	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV036_RS09995	COG2205	protein histidine kinase activity
HV036_RS10005	COG0745	RESPONSE REGULATOR receiver
HV036_RS10010	COG3136	membrane protein required for alginate biosynthesis
HV036_RS10015	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS10020	COG0531	amino acid
HV036_RS10030	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV036_RS10035	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV036_RS10040	COG0668	transmembrane transport
HV036_RS10045	COG0589	response to stress
HV036_RS10055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV036_RS10060	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HV036_RS10065	COG1473	amidohydrolase
HV036_RS10075	COG0583	DNA-binding transcription factor activity
HV036_RS10080	COG2840	Smr protein MutS2
HV036_RS10090	COG0667	Aldo Keto reductase
HV036_RS10100	COG4993	Dehydrogenase
HV036_RS10145	COG1403	HNH endonuclease
HV036_RS10150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV036_RS10160	COG0628	permease
HV036_RS10165	COG2076	Multidrug Resistance protein
HV036_RS10170	COG2076	Multidrug Resistance protein
HV036_RS10175	COG3591	Belongs to the peptidase S1B family
HV036_RS10190	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV036_RS10195	COG2814	Major facilitator Superfamily
HV036_RS10200	COG0583	DNA-binding transcription factor activity
HV036_RS10205	COG1940	carbohydrate kinase activity
HV036_RS10210	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV036_RS10260	COG3141	response to X-ray
HV036_RS10265	COG3381	protein complex oligomerization
HV036_RS10270	COG3302	dmso reductase anchor subunit
HV036_RS10275	COG0437	4 iron, 4 sulfur cluster binding
HV036_RS10280	COG0243	molybdopterin cofactor binding
HV036_RS10300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV036_RS10315	COG4948	Mandelate Racemase Muconate Lactonizing
HV036_RS10320	COG1063	alcohol dehydrogenase
HV036_RS10325	COG0477	Major facilitator Superfamily
HV036_RS10330	COG0246	Mannitol dehydrogenase
HV036_RS10340	COG0589	response to stress
HV036_RS10345	COG1802	Transcriptional regulator
HV036_RS10350	COG4221	oxidoreductase activity
HV036_RS10365	COG1278	Cold shock
HV036_RS10370	COG2135	peptidase activity
HV036_RS10405	COG0598	Magnesium transport protein CorA
HV036_RS10420	COG4993	Dehydrogenase
HV036_RS10445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV036_RS10450	COG2911	Protein conserved in bacteria
HV036_RS10460	COG3784	Protein of unknown function (DUF1318)
HV036_RS10465	COG2207	Transcriptional regulator
HV036_RS10470	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS10475	COG3706	GGDEF domain
HV036_RS10475	COG2203	Gaf domain
HV036_RS10475	COG5001	Diguanylate cyclase
HV036_RS10475	COG4251	negative regulation of phosphorylation
HV036_RS10480	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV036_RS10485	COG3733	amine oxidase
HV036_RS10490	COG2030	dehydratase
HV036_RS10490	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS10495	COG3396	Phenylacetate-CoA oxygenase
HV036_RS10500	COG3460	Phenylacetate-CoA oxygenase
HV036_RS10505	COG3396	Phenylacetate-CoA oxygenase
HV036_RS10510	COG2151	metal-sulfur cluster biosynthetic enzyme
HV036_RS10515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV036_RS10520	COG1024	Enoyl-CoA hydratase
HV036_RS10525	COG1024	Enoyl-CoA hydratase
HV036_RS10530	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV036_RS10535	COG2050	protein possibly involved in aromatic compounds catabolism
HV036_RS10540	COG0183	Belongs to the thiolase family
HV036_RS10545	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HV036_RS10550	COG3327	negative regulation of DNA-templated transcription, initiation
HV036_RS10555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV036_RS10560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV036_RS10570	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV036_RS10590	COG0300	oxidoreductase activity
HV036_RS10605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV036_RS10650	COG3122	Protein conserved in bacteria
HV036_RS10655	COG0564	pseudouridine synthase activity
HV036_RS10665	COG1643	Atp-dependent helicase
HV036_RS10670	COG4122	O-methyltransferase activity
HV036_RS10675	COG1538	Outer membrane efflux protein
HV036_RS10695	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV036_RS10700	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS10705	COG3038	cytochrome b561
HV036_RS10710	COG0673	inositol 2-dehydrogenase activity
HV036_RS10715	COG1349	DNA-binding transcription factor activity
HV036_RS10730	COG2274	protein secretion by the type I secretion system
HV036_RS10785	COG0840	transmembrane signaling receptor activity
HV036_RS10790	COG0583	DNA-binding transcription factor activity
HV036_RS10795	COG5383	Protein conserved in bacteria
HV036_RS10800	COG2272	Belongs to the type-B carboxylesterase lipase family
HV036_RS10810	COG0436	Aminotransferase
HV036_RS10820	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HV036_RS10825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV036_RS10830	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV036_RS10835	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV036_RS10840	COG0500	methyltransferase
HV036_RS10845	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV036_RS10850	COG0747	negative chemotaxis
HV036_RS10870	COG3135	benzoate transporter
HV036_RS10875	COG1396	sequence-specific DNA binding
HV036_RS10880	COG0826	peptidase U32
HV036_RS10905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV036_RS10925	COG1122	ATPase activity
HV036_RS10935	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV036_RS10940	COG2814	Major facilitator Superfamily
HV036_RS10945	COG0697	spore germination
HV036_RS10960	COG1846	Transcriptional regulator
HV036_RS10970	COG2814	Major facilitator Superfamily
HV036_RS10990	COG0583	DNA-binding transcription factor activity
HV036_RS10995	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS11005	COG2066	Belongs to the glutaminase family
HV036_RS11015	COG3706	GGDEF domain
HV036_RS11030	COG3781	membrane
HV036_RS11070	COG0596	Alpha beta hydrolase
HV036_RS11075	COG0745	RESPONSE REGULATOR receiver
HV036_RS11080	COG2205	protein histidine kinase activity
HV036_RS11095	COG0494	nUDIX hydrolase
HV036_RS11100	COG1349	DNA-binding transcription factor activity
HV036_RS11140	COG2814	Major facilitator Superfamily
HV036_RS11165	COG3121	Chaperone
HV036_RS11180	COG3121	Chaperone
HV036_RS11225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HV036_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS11250	COG0583	DNA-binding transcription factor activity
HV036_RS11255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV036_RS11260	COG4628	conserved protein (DUF2132)
HV036_RS11270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV036_RS11285	COG0840	transmembrane signaling receptor activity
HV036_RS11315	COG2200	EAL domain
HV036_RS11330	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV036_RS11335	COG0747	negative chemotaxis
HV036_RS11340	COG0601	transmembrane transport
HV036_RS11345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV036_RS11350	COG0444	Belongs to the ABC transporter superfamily
HV036_RS11355	COG4608	Belongs to the ABC transporter superfamily
HV036_RS11360	COG1764	response to oxidative stress
HV036_RS11390	COG0281	malic enzyme
HV036_RS11405	COG0488	(ABC) transporter
HV036_RS11420	COG1252	NADH dehydrogenase
HV036_RS11425	COG2814	Major facilitator Superfamily
HV036_RS11435	COG2864	formate dehydrogenase
HV036_RS11440	COG0437	4 iron, 4 sulfur cluster binding
HV036_RS11450	COG0697	spore germination
HV036_RS11470	COG2223	nitrite transmembrane transporter activity
HV036_RS11475	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV036_RS11480	COG1140	nitrate reductase beta subunit
HV036_RS11485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV036_RS11490	COG2181	nitrate reductase activity
HV036_RS11495	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV036_RS11500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV036_RS11505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HV036_RS11510	COG0640	Transcriptional regulator
HV036_RS11515	COG0583	DNA-binding transcription factor activity
HV036_RS11520	COG0456	acetyltransferase
HV036_RS11530	COG1560	Kdo2-lipid A biosynthetic process
HV036_RS11535	COG1942	4-Oxalocrotonate Tautomerase
HV036_RS11540	COG0625	glutathione transferase activity
HV036_RS11545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV036_RS11550	COG1126	abc transporter atp-binding protein
HV036_RS11565	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV036_RS11570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV036_RS11575	COG1473	amidohydrolase
HV036_RS11580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV036_RS11605	COG4772	TonB-dependent receptor
HV036_RS11610	COG1802	Transcriptional regulator
HV036_RS11615	COG2130	NADP-dependent
HV036_RS11625	COG1247	-acetyltransferase
HV036_RS11630	COG3238	Protein conserved in bacteria
HV036_RS11640	COG0747	negative chemotaxis
HV036_RS11670	COG3615	Tellurite resistance protein tehB
HV036_RS11675	COG3615	Tellurite resistance protein tehB
HV036_RS11685	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS11690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV036_RS11700	COG1271	oxidase subunit
HV036_RS11705	COG1294	oxidase, subunit
HV036_RS11715	COG3187	Heat shock protein
HV036_RS11720	COG3042	response to heat
HV036_RS11725	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV036_RS11725	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV036_RS11725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV036_RS11725	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV036_RS11730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV036_RS11755	COG0513	Belongs to the DEAD box helicase family
HV036_RS11770	COG0840	transmembrane signaling receptor activity
HV036_RS11815	COG4166	transmembrane transport
HV036_RS11820	COG2866	Carboxypeptidase
HV036_RS11825	COG4948	Mandelate Racemase Muconate Lactonizing
HV036_RS11830	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV036_RS11840	COG3768	UPF0283 membrane protein
HV036_RS11845	COG3106	COG3106 Predicted ATPase
HV036_RS11850	COG1609	Transcriptional regulator
HV036_RS11860	COG3842	ATPase activity
HV036_RS11865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV036_RS11870	COG1554	hydrolase, family 65, central catalytic
HV036_RS11875	COG0673	inositol 2-dehydrogenase activity
HV036_RS11880	COG1082	Xylose isomerase domain protein TIM barrel
HV036_RS11885	COG1063	alcohol dehydrogenase
HV036_RS11890	COG0395	ABC-type sugar transport system, permease component
HV036_RS11895	COG1175	transmembrane transport
HV036_RS11900	COG1653	transport
HV036_RS11905	COG0366	Alpha amylase catalytic
HV036_RS11915	COG1983	PspC domain protein
HV036_RS11925	COG1842	Phage shock protein A
HV036_RS11930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV036_RS11945	COG4171	peptide transport system, permease
HV036_RS11955	COG4172	Belongs to the ABC transporter superfamily
HV036_RS11960	COG1309	transcriptional regulator
HV036_RS11965	COG0251	oxidation-reduction process
HV036_RS11970	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV036_RS11975	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV036_RS11975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV036_RS11980	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HV036_RS11985	COG5001	Diguanylate cyclase
HV036_RS11990	COG1024	Enoyl-CoA hydratase
HV036_RS12000	COG1349	DNA-binding transcription factor activity
HV036_RS12010	COG0023	Translation Initiation Factor
HV036_RS12015	COG0284	orotidine-5'-phosphate decarboxylase activity
HV036_RS12020	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV036_RS12025	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV036_RS12030	COG0671	phosphoesterase, PA-phosphatase related
HV036_RS12040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV036_RS12070	COG0616	signal peptide processing
HV036_RS12075	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS12080	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HV036_RS12160	COG0463	Glycosyl transferase, family 2
HV036_RS12165	COG0009	L-threonylcarbamoyladenylate synthase
HV036_RS12170	COG0613	PHP domain protein
HV036_RS12185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV036_RS12185	COG0512	Glutamine amidotransferase of anthranilate synthase
HV036_RS12195	COG0133	tryptophan synthase activity
HV036_RS12200	COG0159	tryptophan synthase activity
HV036_RS12205	COG2391	methyltransferase activity
HV036_RS12210	COG0425	Belongs to the sulfur carrier protein TusA family
HV036_RS12215	COG3047	cAMP biosynthetic process
HV036_RS12220	COG0727	PFAM Uncharacterised protein family (UPF0153)
HV036_RS12250	COG2350	Protein conserved in bacteria
HV036_RS12255	COG2963	transposase activity
HV036_RS12270	COG1280	lysine exporter protein (LysE YggA)
HV036_RS12290	COG3099	Belongs to the UPF0263 family
HV036_RS12295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV036_RS12300	COG4608	Belongs to the ABC transporter superfamily
HV036_RS12305	COG0444	Belongs to the ABC transporter superfamily
HV036_RS12325	COG2095	MarC family integral membrane protein
HV036_RS12330	COG1454	alcohol dehydrogenase
HV036_RS12330	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS12335	COG1435	thymidine kinase activity
HV036_RS12345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV036_RS12350	COG0745	RESPONSE REGULATOR receiver
HV036_RS12355	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV036_RS12360	COG3012	SEC-C Motif Domain Protein
HV036_RS12365	COG0788	formyltetrahydrofolate deformylase activity
HV036_RS12380	COG2181	nitrate reductase activity
HV036_RS12385	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV036_RS12390	COG1140	nitrate reductase beta subunit
HV036_RS12395	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV036_RS12400	COG2223	nitrite transmembrane transporter activity
HV036_RS12405	COG3850	Histidine kinase
HV036_RS12410	COG2197	response regulator
HV036_RS12415	COG4932	domain protein
HV036_RS12420	COG0243	molybdopterin cofactor binding
HV036_RS12425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV036_RS12425	COG2146	nitrite reductase [NAD(P)H] activity
HV036_RS12430	COG1116	anion transmembrane transporter activity
HV036_RS12440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV036_RS12445	COG3707	response regulator
HV036_RS12450	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV036_RS12455	COG0840	transmembrane signaling receptor activity
HV036_RS12465	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV036_RS12470	COG4572	Cation transport regulator
HV036_RS12475	COG0387	Pfam Sodium calcium exchanger
HV036_RS12480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HV036_RS12495	COG2890	protein-(glutamine-N5) methyltransferase activity
HV036_RS12505	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HV036_RS12515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HV036_RS12525	COG0659	secondary active sulfate transmembrane transporter activity
HV036_RS12540	COG0193	aminoacyl-tRNA hydrolase activity
HV036_RS12545	COG0012	GTP binding
HV036_RS12595	COG3209	COG3209 Rhs family protein
HV036_RS12610	COG3501	Rhs element vgr protein
HV036_RS12630	COG0515	serine threonine protein kinase
HV036_RS12760	COG4977	sequence-specific DNA binding
HV036_RS12765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV036_RS12775	COG4774	siderophore transport
HV036_RS12785	COG0741	lytic transglycosylase activity
HV036_RS12790	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV036_RS12795	COG3263	regulation of cellular component size
HV036_RS12800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV036_RS12805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV036_RS12810	COG2719	SpoVR family
HV036_RS12820	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV036_RS12830	COG2983	Belongs to the UPF0260 family
HV036_RS12835	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV036_RS12845	COG0850	regulation of cytokinetic process
HV036_RS12850	COG2894	cell division
HV036_RS12855	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HV036_RS12860	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV036_RS12865	COG0318	PFAM AMP-dependent synthetase and ligase
HV036_RS12870	COG3065	identical protein binding
HV036_RS12875	COG1214	PFAM Peptidase M22, glycoprotease
HV036_RS12880	COG1199	ATP-dependent helicase activity
HV036_RS12885	COG0251	oxidation-reduction process
HV036_RS12890	COG3140	Belongs to the UPF0181 family
HV036_RS12905	COG1760	l-serine dehydratase
HV036_RS12910	COG2200	EAL domain
HV036_RS12915	COG1253	flavin adenine dinucleotide binding
HV036_RS12920	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV036_RS12920	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS12925	COG3715	PTS system
HV036_RS12930	COG3716	PTS system mannose fructose sorbose family IID component
HV036_RS12935	COG4811	Protein of unknown function (DUF986)
HV036_RS12940	COG1971	Probably functions as a manganese efflux pump
HV036_RS12945	COG2226	methyltransferase
HV036_RS12950	COG0768	penicillin binding
HV036_RS12980	COG1414	Transcriptional regulator
HV036_RS12985	COG2814	Major facilitator Superfamily
HV036_RS12990	COG0501	Belongs to the peptidase M48B family
HV036_RS13000	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HV036_RS13005	COG1956	GAF domain-containing protein
HV036_RS13010	COG2995	paraquat-inducible protein a
HV036_RS13015	COG3008	intermembrane lipid transfer
HV036_RS13020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HV036_RS13020	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HV036_RS13035	COG2990	Protein conserved in bacteria
HV036_RS13045	COG1276	copper resistance
HV036_RS13050	COG2372	response to copper ion
HV036_RS13060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV036_RS13065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV036_RS13070	COG1770	oligopeptidase
HV036_RS13075	COG2979	Protein of unknown function (DUF533)
HV036_RS13095	COG0800	Aldolase
HV036_RS13100	COG0129	dihydroxy-acid dehydratase activity
HV036_RS13105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV036_RS13110	COG1737	Transcriptional regulator
HV036_RS13120	COG1560	Kdo2-lipid A biosynthetic process
HV036_RS13125	COG0739	heme binding
HV036_RS13130	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV036_RS13140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV036_RS13145	COG2255	four-way junction helicase activity
HV036_RS13150	COG0632	four-way junction helicase activity
HV036_RS13165	COG0494	nUDIX hydrolase
HV036_RS13175	COG1335	isochorismatase
HV036_RS13180	COG1801	Protein of unknown function DUF72
HV036_RS13185	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV036_RS13190	COG2226	methyltransferase
HV036_RS13195	COG0500	methyltransferase
HV036_RS13200	COG3142	Participates in the control of copper homeostasis
HV036_RS13205	COG3102	Protein conserved in bacteria
HV036_RS13210	COG0018	arginyl-trna synthetase
HV036_RS13225	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV036_RS13255	COG0745	RESPONSE REGULATOR receiver
HV036_RS13270	COG0840	transmembrane signaling receptor activity
HV036_RS13305	COG1301	dicarboxylic acid transport
HV036_RS13345	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HV036_RS13355	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS13365	COG1879	ABC-type sugar transport system periplasmic component
HV036_RS13375	COG1528	Iron-storage protein
HV036_RS13380	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV036_RS13410	COG1528	Iron-storage protein
HV036_RS13420	COG0814	amino acid
HV036_RS13425	COG3318	Belongs to the UPF0149 family
HV036_RS13425	COG3012	SEC-C Motif Domain Protein
HV036_RS13460	COG0583	DNA-binding transcription factor activity
HV036_RS13490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV036_RS13500	COG3012	SEC-C Motif Domain Protein
HV036_RS13500	COG3318	Belongs to the UPF0149 family
HV036_RS13550	COG3596	GTP binding
HV036_RS13725	COG4695	Portal protein
HV036_RS13795	COG4974	Belongs to the 'phage' integrase family
HV036_RS13825	COG2197	response regulator
HV036_RS13835	COG2197	response regulator
HV036_RS13875	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV036_RS13880	COG1516	flagellar protein fliS
HV036_RS13890	COG0366	Alpha amylase catalytic
HV036_RS13900	COG1677	Flagellar hook-basal body complex protein FliE
HV036_RS13910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HV036_RS13920	COG1157	protein secretion by the type III secretion system
HV036_RS13960	COG1987	bacterial-type flagellum assembly
HV036_RS13970	COG2197	response regulator
HV036_RS13995	COG5475	Uncharacterized small protein (DUF2158)
HV036_RS14000	COG2354	Protein conserved in bacteria
HV036_RS14005	COG0697	spore germination
HV036_RS14010	COG3727	T/G mismatch-specific endonuclease activity
HV036_RS14015	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV036_RS14020	COG1418	mRNA catabolic process
HV036_RS14025	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV036_RS14035	COG3290	protein histidine kinase activity
HV036_RS14040	COG4565	transcriptional regulatory protein
HV036_RS14060	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV036_RS14060	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV036_RS14085	COG0583	DNA-binding transcription factor activity
HV036_RS14145	COG1376	ErfK ybiS ycfS ynhG family protein
HV036_RS14150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HV036_RS14155	COG0589	response to stress
HV036_RS14160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS14165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV036_RS14180	COG0477	Major facilitator Superfamily
HV036_RS14185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV036_RS14190	COG0006	proline dipeptidase activity
HV036_RS14200	COG0534	Mate efflux family protein
HV036_RS14215	COG1289	transmembrane transporter activity
HV036_RS14220	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV036_RS14230	COG2925	Exonuclease
HV036_RS14235	COG0531	amino acid
HV036_RS14245	COG0583	DNA-binding transcription factor activity
HV036_RS14250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV036_RS14260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HV036_RS14270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV036_RS14275	COG0131	Imidazoleglycerol-phosphate dehydratase
HV036_RS14275	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV036_RS14280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV036_RS14285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HV036_RS14290	COG0107	imidazoleglycerol-phosphate synthase activity
HV036_RS14295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HV036_RS14295	COG0140	phosphoribosyl-ATP diphosphatase activity
HV036_RS14300	COG3385	transposase activity
HV036_RS14335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV036_RS14355	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV036_RS14375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV036_RS14395	COG0438	transferase activity, transferring glycosyl groups
HV036_RS14400	COG2327	Polysaccharide pyruvyl transferase
HV036_RS14405	COG2244	polysaccharide biosynthetic process
HV036_RS14410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV036_RS14415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV036_RS14425	COG0297	glycogen (starch) synthase activity
HV036_RS14430	COG1051	belongs to the nudix hydrolase family
HV036_RS14435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV036_RS14440	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV036_RS14445	COG0110	maltose O-acetyltransferase activity
HV036_RS14450	COG1216	Glycosyl transferase, family 2
HV036_RS14460	COG0438	transferase activity, transferring glycosyl groups
HV036_RS14465	COG1045	serine acetyltransferase
HV036_RS14470	COG0463	Glycosyl transferase, family 2
HV036_RS14475	COG3206	protein involved in exopolysaccharide biosynthesis
HV036_RS14475	COG0489	protein tyrosine kinase activity
HV036_RS14490	COG1253	flavin adenine dinucleotide binding
HV036_RS14495	COG2982	Protein involved in outer membrane biogenesis
HV036_RS14500	COG0717	Belongs to the dCTP deaminase family
HV036_RS14510	COG3447	MASE1 domain protein
HV036_RS14510	COG5001	Diguanylate cyclase
HV036_RS14510	COG5002	protein histidine kinase activity
HV036_RS14515	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV036_RS14520	COG0443	Heat shock 70 kDa protein
HV036_RS14525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS14530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV036_RS14535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV036_RS14540	COG0477	Major facilitator Superfamily
HV036_RS14545	COG2205	protein histidine kinase activity
HV036_RS14550	COG0745	RESPONSE REGULATOR receiver
HV036_RS14570	COG1597	lipid kinase activity
HV036_RS14575	COG1830	Aldolase
HV036_RS14580	COG2211	Major facilitator Superfamily
HV036_RS14585	COG1397	ADP-ribosylglycohydrolase
HV036_RS14590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV036_RS14595	COG2188	Transcriptional regulator
HV036_RS14600	COG0351	phosphomethylpyrimidine kinase
HV036_RS14605	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HV036_RS14625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV036_RS14630	COG0076	glutamate decarboxylase activity
HV036_RS14635	COG0489	protein tyrosine kinase activity
HV036_RS14635	COG3206	protein involved in exopolysaccharide biosynthesis
HV036_RS14640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HV036_RS14645	COG1596	polysaccharide export
HV036_RS14650	COG5455	response to cobalt ion
HV036_RS14655	COG0456	acetyltransferase
HV036_RS14660	COG0489	protein tyrosine kinase activity
HV036_RS14670	COG4807	Protein conserved in bacteria
HV036_RS14675	COG3279	Response regulator of the LytR AlgR family
HV036_RS14680	COG3275	phosphorelay sensor kinase activity
HV036_RS14685	COG0789	Transcriptional regulator
HV036_RS14695	COG1174	glycine betaine transport
HV036_RS14700	COG1125	glycine betaine transport
HV036_RS14705	COG1174	glycine betaine transport
HV036_RS14710	COG1732	Glycine betaine
HV036_RS14715	COG1472	Belongs to the glycosyl hydrolase 3 family
HV036_RS14720	COG0277	FAD linked oxidase domain protein
HV036_RS14730	COG1686	Belongs to the peptidase S11 family
HV036_RS14740	COG0586	Pfam SNARE associated Golgi protein
HV036_RS14745	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS14750	COG1538	Outer membrane efflux protein
HV036_RS14755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV036_RS14765	COG1346	cytolysis
HV036_RS14770	COG0295	cytidine deaminase activity
HV036_RS14775	COG2949	membrane
HV036_RS14785	COG1129	ABC transporter
HV036_RS14800	COG2311	Membrane
HV036_RS14810	COG0477	Major facilitator Superfamily
HV036_RS14815	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HV036_RS14820	COG4771	TonB-dependent receptor
HV036_RS14825	COG0833	amino acid
HV036_RS14830	COG0583	DNA-binding transcription factor activity
HV036_RS14835	COG2855	membrane
HV036_RS14840	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HV036_RS14845	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV036_RS14845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV036_RS14845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV036_RS14850	COG1105	Belongs to the carbohydrate kinase PfkB family
HV036_RS14870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HV036_RS14875	COG1312	Catalyzes the dehydration of D-mannonate
HV036_RS14880	COG0246	Mannitol dehydrogenase
HV036_RS14885	COG0523	cobalamin synthesis protein
HV036_RS14890	COG0671	phosphoesterase, PA-phosphatase related
HV036_RS14895	COG0791	NLP P60 protein
HV036_RS14900	COG2200	EAL domain
HV036_RS14905	COG4166	transmembrane transport
HV036_RS14910	COG4174	ABC transporter (Permease)
HV036_RS14915	COG4239	(ABC) transporter, permease
HV036_RS14920	COG4172	Belongs to the ABC transporter superfamily
HV036_RS14930	COG2814	Major facilitator Superfamily
HV036_RS14935	COG1187	pseudouridine synthase activity
HV036_RS14940	COG1061	Type III restriction enzyme res subunit
HV036_RS14950	COG3081	Nucleoid-associated protein
HV036_RS14955	COG3082	Protein of unknown function (DUF1414)
HV036_RS14970	COG3182	Iron-regulated membrane protein
HV036_RS14980	COG0579	oxidoreductase
HV036_RS14985	COG0659	secondary active sulfate transmembrane transporter activity
HV036_RS14990	COG2239	Acts as a magnesium transporter
HV036_RS14995	COG4615	Cyclic peptide transporter
HV036_RS15005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV036_RS15005	COG2169	Transcriptional regulator
HV036_RS15020	COG0642	Histidine kinase
HV036_RS15020	COG2198	Histidine kinase
HV036_RS15040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV036_RS15055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV036_RS15060	COG0584	glycerophosphoryl diester phosphodiesterase
HV036_RS15065	COG2271	Major facilitator Superfamily
HV036_RS15070	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV036_RS15075	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HV036_RS15080	COG0247	lactate metabolic process
HV036_RS15095	COG0642	Histidine kinase
HV036_RS15125	COG1441	menaquinone biosynthetic process
HV036_RS15135	COG0596	Alpha beta hydrolase
HV036_RS15140	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HV036_RS15145	COG1169	isochorismate synthase
HV036_RS15150	COG4575	ribosome binding
HV036_RS15155	COG2153	protein acetylation
HV036_RS15160	COG1234	tRNA 3'-trailer cleavage
HV036_RS15165	COG0784	Response regulator, receiver
HV036_RS15165	COG0835	chemotaxis
HV036_RS15170	COG1007	ATP synthesis coupled electron transport
HV036_RS15175	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV036_RS15180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV036_RS15185	COG0713	ATP synthesis coupled electron transport
HV036_RS15190	COG0839	Belongs to the complex I subunit 6 family
HV036_RS15200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HV036_RS15230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV036_RS15235	COG0583	DNA-binding transcription factor activity
HV036_RS15240	COG0436	Aminotransferase
HV036_RS15250	COG0471	metal ion transport
HV036_RS15250	COG0490	domain, Protein
HV036_RS15255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV036_RS15280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV036_RS15285	COG3959	Transketolase, thiamine diphosphate binding domain
HV036_RS15290	COG3037	sugar-specific permease SgaT UlaA
HV036_RS15300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS15305	COG1609	Transcriptional regulator
HV036_RS15315	COG0622	Phosphoesterase
HV036_RS15320	COG0625	glutathione transferase activity
HV036_RS15325	COG0625	glutathione transferase activity
HV036_RS15330	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV036_RS15335	COG1090	epimerase
HV036_RS15340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV036_RS15345	COG4598	ABC transporter
HV036_RS15350	COG4160	amino acid transport
HV036_RS15360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV036_RS15370	COG0163	prenyltransferase activity
HV036_RS15375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV036_RS15380	COG1286	toxin biosynthetic process
HV036_RS15385	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV036_RS15390	COG0285	dihydrofolate synthase activity
HV036_RS15395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HV036_RS15400	COG0586	Pfam SNARE associated Golgi protein
HV036_RS15405	COG0101	tRNA pseudouridine synthase activity
HV036_RS15410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV036_RS15415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV036_RS15430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV036_RS15435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV036_RS15435	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HV036_RS15445	COG3101	peptidyl-lysine hydroxylation
HV036_RS15450	COG0730	response to heat
HV036_RS15470	COG2840	Smr protein MutS2
HV036_RS15475	COG2062	phosphohistidine phosphatase, SixA
HV036_RS15480	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV036_RS15480	COG1024	Enoyl-CoA hydratase
HV036_RS15490	COG3691	Protein conserved in bacteria
HV036_RS15495	COG2067	long-chain fatty acid transport protein
HV036_RS15505	COG2116	formate transmembrane transporter activity
HV036_RS15515	COG1560	Kdo2-lipid A biosynthetic process
HV036_RS15525	COG0436	Aminotransferase
HV036_RS15530	COG3275	phosphorelay sensor kinase activity
HV036_RS15535	COG3279	Response regulator of the LytR AlgR family
HV036_RS15540	COG0837	glucose binding
HV036_RS15550	COG3961	Belongs to the TPP enzyme family
HV036_RS15555	COG0667	Aldo Keto reductase
HV036_RS15565	COG1914	H( )-stimulated, divalent metal cation uptake system
HV036_RS15570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV036_RS15575	COG2199	diguanylate cyclase activity
HV036_RS15575	COG2200	EAL domain
HV036_RS15590	COG3415	Transposase
HV036_RS15595	COG3415	Transposase
HV036_RS15600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV036_RS15630	COG0583	DNA-binding transcription factor activity
HV036_RS15635	COG0385	Bile acid
HV036_RS15640	COG3530	Putative quorum-sensing-regulated virulence factor
HV036_RS15645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HV036_RS15650	COG3115	cell septum assembly
HV036_RS15665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS15690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV036_RS15695	COG4208	sulfate ABC transporter
HV036_RS15700	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV036_RS15705	COG4150	thiosulfate binding
HV036_RS15710	COG2837	iron assimilation
HV036_RS15735	COG0408	coproporphyrinogen oxidase activity
HV036_RS15750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV036_RS15755	COG5342	invasion associated locus B
HV036_RS15760	COG0494	nUDIX hydrolase
HV036_RS15765	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV036_RS15765	COG0493	'glutamate synthase
HV036_RS15770	COG3850	Histidine kinase
HV036_RS15775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV036_RS15785	COG1393	Belongs to the ArsC family
HV036_RS15790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV036_RS15800	COG0400	carboxylic ester hydrolase activity
HV036_RS15810	COG2321	neutral zinc metallopeptidase
HV036_RS15815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HV036_RS15820	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV036_RS15830	COG2716	regulation of RNA biosynthetic process
HV036_RS15835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV036_RS15840	COG0628	permease
HV036_RS15845	COG4783	chaperone-mediated protein folding
HV036_RS15850	COG1393	Belongs to the ArsC family
HV036_RS15865	COG1446	asparaginase
HV036_RS15880	COG2233	PERMEase
HV036_RS15885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HV036_RS15890	COG2723	6-phospho-beta-galactosidase activity
HV036_RS15900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV036_RS15915	COG2200	EAL domain
HV036_RS15935	COG3713	MltA-interacting MipA family protein
HV036_RS15940	COG0745	RESPONSE REGULATOR receiver
HV036_RS15960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS15965	COG3708	Transcriptional regulator
HV036_RS15965	COG2207	Transcriptional regulator
HV036_RS15985	COG0517	IMP dehydrogenase activity
HV036_RS15985	COG0516	GMP reductase activity
HV036_RS15990	COG1570	exodeoxyribonuclease VII activity
HV036_RS16005	COG1645	bacterial-type flagellum-dependent swarming motility
HV036_RS16010	COG3104	oligopeptide transport
HV036_RS16015	COG1160	GTP binding
HV036_RS16025	COG2976	Protein conserved in bacteria
HV036_RS16030	COG0124	histidyl-tRNA synthetase
HV036_RS16035	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HV036_RS16045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HV036_RS16060	COG3302	dmso reductase anchor subunit
HV036_RS16065	COG0437	4 iron, 4 sulfur cluster binding
HV036_RS16075	COG4953	penicillin-binding protein 1C
HV036_RS16080	COG2373	Large extracellular alpha-helical protein
HV036_RS16085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV036_RS16085	COG2190	(PTS) system
HV036_RS16085	COG1263	PTS System
HV036_RS16095	COG2897	thiosulfate sulfurtransferase activity
HV036_RS16100	COG1737	Transcriptional regulator
HV036_RS16110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV036_RS16115	COG2975	iron-sulfur cluster assembly
HV036_RS16120	COG0633	Ferredoxin
HV036_RS16125	COG0443	Heat shock 70 kDa protein
HV036_RS16130	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV036_RS16135	COG0316	Belongs to the HesB IscA family
HV036_RS16140	COG0822	iron-sulfur transferase activity
HV036_RS16145	COG1104	cysteine desulfurase activity
HV036_RS16165	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV036_RS16175	COG3711	transcriptional antiterminator
HV036_RS16180	COG2814	Major facilitator Superfamily
HV036_RS16185	COG2259	Doxx family
HV036_RS16195	COG1017	nitric oxide dioxygenase activity
HV036_RS16195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV036_RS16200	COG0347	Belongs to the P(II) protein family
HV036_RS16205	COG2204	response regulator
HV036_RS16210	COG3170	Tfp pilus assembly protein FimV
HV036_RS16215	COG2205	protein histidine kinase activity
HV036_RS16220	COG0047	phosphoribosylformylglycinamidine synthase activity
HV036_RS16220	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HV036_RS16225	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV036_RS16235	COG0560	Phosphoserine phosphatase
HV036_RS16245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV036_RS16250	COG1737	Transcriptional regulator
HV036_RS16255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV036_RS16265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV036_RS16270	COG1381	Involved in DNA repair and RecF pathway recombination
HV036_RS16285	COG0681	Belongs to the peptidase S26 family
HV036_RS16365	COG1196	nuclear chromosome segregation
HV036_RS16470	COG3772	lysozyme
HV036_RS16540	COG1349	DNA-binding transcription factor activity
HV036_RS16555	COG1846	Transcriptional regulator
HV036_RS16590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV036_RS16620	COG3086	response to oxidative stress
HV036_RS16640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV036_RS16645	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HV036_RS16650	COG0513	Belongs to the DEAD box helicase family
HV036_RS16655	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HV036_RS16660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HV036_RS16665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV036_RS16670	COG3118	belongs to the thioredoxin family
HV036_RS16680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV036_RS16680	COG0045	succinate-CoA ligase (ADP-forming) activity
HV036_RS16680	COG1042	CoA-binding domain protein
HV036_RS16685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV036_RS16690	COG5544	Lipoprotein
HV036_RS16695	COG0477	Major facilitator Superfamily
HV036_RS16725	COG0542	response to heat
HV036_RS16735	COG0564	pseudouridine synthase activity
HV036_RS16740	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV036_RS16745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV036_RS16755	COG1605	Chorismate mutase
HV036_RS16755	COG0077	Prephenate dehydratase
HV036_RS16790	COG0287	Prephenate dehydrogenase
HV036_RS16790	COG1605	Chorismate mutase
HV036_RS16795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV036_RS16805	COG2199	diguanylate cyclase activity
HV036_RS16810	COG2885	chlorophyll binding
HV036_RS16830	COG0336	Belongs to the RNA methyltransferase TrmD family
HV036_RS16835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HV036_RS16845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV036_RS16850	COG4137	Cytochrome C assembly protein
HV036_RS16855	COG4536	flavin adenine dinucleotide binding
HV036_RS16860	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HV036_RS16865	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HV036_RS16870	COG0497	DNA recombination
HV036_RS16885	COG2867	negative regulation of translational initiation
HV036_RS16900	COG0582	viral genome integration into host DNA
HV036_RS16910	COG3311	Transcriptional regulator
HV036_RS16915	COG4983	Phage plasmid primase, P4 family domain protein
HV036_RS16950	COG0071	Belongs to the small heat shock protein (HSP20) family
HV036_RS16955	COG0542	response to heat
HV036_RS17015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV036_RS17020	COG3039	Transposase
HV036_RS17030	COG2826	transposase and inactivated derivatives, IS30 family
HV036_RS17040	COG3596	GTP binding
HV036_RS17050	COG2378	regulation of single-species biofilm formation
HV036_RS17095	COG2003	Belongs to the UPF0758 family
HV036_RS17115	COG0675	Transposase, IS605 OrfB family
HV036_RS17165	COG4695	Portal protein
HV036_RS17170	COG4626	Terminase
HV036_RS17170	COG1802	Transcriptional regulator
HV036_RS17220	COG3179	chitinase
HV036_RS17240	COG0484	heat shock protein binding
HV036_RS17310	COG0582	viral genome integration into host DNA
HV036_RS17315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV036_RS17320	COG4209	transmembrane transport
HV036_RS17325	COG0395	ABC-type sugar transport system, permease component
HV036_RS17340	COG3842	ATPase activity
HV036_RS17345	COG0154	amidase activity
HV036_RS17350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HV036_RS17370	COG2814	Major facilitator Superfamily
HV036_RS17375	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HV036_RS17380	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS17385	COG1073	alpha beta
HV036_RS17385	COG2226	methyltransferase
HV036_RS17400	COG0583	DNA-binding transcription factor activity
HV036_RS17410	COG4977	sequence-specific DNA binding
HV036_RS17410	COG1917	Cupin 2, conserved barrel domain protein
HV036_RS17415	COG4221	oxidoreductase activity
HV036_RS17420	COG4221	oxidoreductase activity
HV036_RS17445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS17450	COG1051	belongs to the nudix hydrolase family
HV036_RS17465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV036_RS17470	COG0583	DNA-binding transcription factor activity
HV036_RS17480	COG2226	methyltransferase
HV036_RS17485	COG0402	S-adenosylhomocysteine deaminase activity
HV036_RS17490	COG0549	Belongs to the carbamate kinase family
HV036_RS17500	COG1304	FMN binding
HV036_RS17505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV036_RS17510	COG0666	response to abiotic stimulus
HV036_RS17515	COG0583	DNA-binding transcription factor activity
HV036_RS17520	COG0401	homolog of Blt101
HV036_RS17525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV036_RS17550	COG4575	ribosome binding
HV036_RS17560	COG1780	Probably involved in ribonucleotide reductase function
HV036_RS17565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV036_RS17575	COG4175	Glycine betaine
HV036_RS17580	COG4176	ABC-type proline glycine betaine transport system permease component
HV036_RS17590	COG2814	Major facilitator Superfamily
HV036_RS17595	COG1846	Transcriptional regulator
HV036_RS17600	COG1566	PFAM secretion protein HlyD family protein
HV036_RS17605	COG2814	Major facilitator Superfamily
HV036_RS17615	COG2918	glutathione biosynthetic process
HV036_RS17620	COG1238	metal cluster binding
HV036_RS17625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV036_RS17655	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV036_RS17660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HV036_RS17675	COG1546	Belongs to the CinA family
HV036_RS17685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV036_RS17695	COG2951	lytic endotransglycosylase activity
HV036_RS17700	COG3730	PTS system glucitol sorbitol-specific
HV036_RS17705	COG3732	PTS system glucitol sorbitol-specific
HV036_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS17720	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS17725	COG1349	DNA-binding transcription factor activity
HV036_RS17735	COG3604	Transcriptional regulator
HV036_RS17740	COG0426	domain, Protein
HV036_RS17740	COG1773	rubredoxin
HV036_RS17745	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV036_RS17750	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV036_RS17755	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV036_RS17760	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV036_RS17765	COG1609	Transcriptional regulator
HV036_RS17770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV036_RS17770	COG1263	PTS System
HV036_RS17775	COG2723	6-phospho-beta-galactosidase activity
HV036_RS17780	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV036_RS17790	COG3260	NADH ubiquinone oxidoreductase 20
HV036_RS17795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV036_RS17800	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV036_RS17800	COG3261	NADH dehydrogenase
HV036_RS17805	COG0650	Formate hydrogenlyase subunit 4
HV036_RS17810	COG0651	ATP synthesis coupled electron transport
HV036_RS17815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV036_RS17825	COG0375	protein maturation
HV036_RS17830	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV036_RS17835	COG0298	carbon dioxide binding
HV036_RS17840	COG0409	Hydrogenase expression formation protein
HV036_RS17845	COG0309	Hydrogenase expression formation protein (HypE)
HV036_RS17865	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HV036_RS17875	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV036_RS17880	COG0163	prenyltransferase activity
HV036_RS17910	COG4942	peptidase
HV036_RS17910	COG1388	LysM domain
HV036_RS17925	COG0585	pseudouridine synthase activity
HV036_RS17930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HV036_RS17935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HV036_RS17940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HV036_RS17950	COG0529	Catalyzes the synthesis of activated sulfate
HV036_RS17970	COG2234	aminopeptidase activity
HV036_RS17985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HV036_RS17990	COG0720	synthase
HV036_RS17995	COG2207	Transcriptional regulator
HV036_RS18000	COG1473	amidohydrolase
HV036_RS18010	COG0602	queuosine metabolic process
HV036_RS18015	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV036_RS18020	COG2190	(PTS) system
HV036_RS18020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV036_RS18020	COG1263	PTS System
HV036_RS18025	COG1737	Transcriptional regulator
HV036_RS18040	COG3956	TIGRFAM MazG family protein
HV036_RS18045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV036_RS18050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV036_RS18055	COG3850	Histidine kinase
HV036_RS18055	COG3437	response regulator, receiver
HV036_RS18055	COG2205	protein histidine kinase activity
HV036_RS18055	COG4999	Histidine kinase
HV036_RS18060	COG1929	Belongs to the glycerate kinase type-1 family
HV036_RS18065	COG4948	Mandelate Racemase Muconate Lactonizing
HV036_RS18070	COG4948	Mandelate Racemase Muconate Lactonizing
HV036_RS18075	COG2271	Major facilitator Superfamily
HV036_RS18080	COG0716	FMN binding
HV036_RS18085	COG0564	pseudouridine synthase activity
HV036_RS18090	COG3098	single-species biofilm formation
HV036_RS18105	COG1611	Belongs to the LOG family
HV036_RS18110	COG0814	amino acid
HV036_RS18115	COG1760	l-serine dehydratase
HV036_RS18125	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HV036_RS18130	COG2363	Small membrane protein
HV036_RS18135	COG0583	DNA-binding transcription factor activity
HV036_RS18145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV036_RS18150	COG2166	iron-sulfur cluster assembly
HV036_RS18155	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV036_RS18160	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV036_RS18180	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV036_RS18185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV036_RS18185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV036_RS18190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV036_RS18195	COG1074	ATP-dependent DNA helicase activity
HV036_RS18205	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV036_RS18210	COG4967	type IV pilus modification protein PilV
HV036_RS18220	COG4795	General secretion pathway protein
HV036_RS18225	COG2165	general secretion pathway protein
HV036_RS18230	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HV036_RS18235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HV036_RS18245	COG0494	nUDIX hydrolase
HV036_RS18250	COG3066	DNA modification
HV036_RS18260	COG0667	Aldo Keto reductase
HV036_RS18265	COG0477	Major facilitator Superfamily
HV036_RS18270	COG0318	PFAM AMP-dependent synthetase and ligase
HV036_RS18270	COG0204	Acyl-transferase
HV036_RS18275	COG1609	Transcriptional regulator
HV036_RS18285	COG2186	Transcriptional regulator
HV036_RS18290	COG2723	6-phospho-beta-galactosidase activity
HV036_RS18295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV036_RS18300	COG1609	Transcriptional regulator
HV036_RS18310	COG0583	DNA-binding transcription factor activity
HV036_RS18315	COG1794	racemase activity, acting on amino acids and derivatives
HV036_RS18325	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV036_RS18330	COG1175	transmembrane transport
HV036_RS18335	COG0395	ABC-type sugar transport system, permease component
HV036_RS18340	COG3842	ATPase activity
HV036_RS18350	COG2814	Major facilitator Superfamily
HV036_RS18355	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS18365	COG0823	Involved in the tonB-independent uptake of proteins
HV036_RS18370	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV036_RS18375	COG0183	Belongs to the thiolase family
HV036_RS18390	COG0814	amino acid
HV036_RS18395	COG2388	GCN5-related N-acetyl-transferase
HV036_RS18400	COG3592	Divergent 4Fe-4S mono-cluster
HV036_RS18405	COG3729	General stress protein
HV036_RS18410	COG3685	Protein conserved in bacteria
HV036_RS18415	COG3685	Protein conserved in bacteria
HV036_RS18420	COG3546	catalase activity
HV036_RS18425	COG1271	oxidase subunit
HV036_RS18430	COG1294	oxidase, subunit
HV036_RS18445	COG1546	Belongs to the CinA family
HV036_RS18460	COG3111	PFAM Bacterial OB fold (BOF) protein
HV036_RS18465	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS18470	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV036_RS18490	COG2067	long-chain fatty acid transport protein
HV036_RS18495	COG1280	lysine exporter protein (LysE YggA)
HV036_RS18510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV036_RS18530	COG4942	peptidase
HV036_RS18535	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HV036_RS18540	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HV036_RS18550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV036_RS18560	COG4974	Belongs to the 'phage' integrase family
HV036_RS18575	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV036_RS18580	COG0354	folic acid binding
HV036_RS18585	COG1272	protein, Hemolysin III
HV036_RS18590	COG1737	Transcriptional regulator
HV036_RS18595	COG2723	6-phospho-beta-galactosidase activity
HV036_RS18615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV036_RS18620	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS18625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HV036_RS18625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HV036_RS18635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HV036_RS18640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV036_RS18645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV036_RS18650	COG0006	proline dipeptidase activity
HV036_RS18660	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HV036_RS18670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV036_RS18680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV036_RS18690	COG0583	DNA-binding transcription factor activity
HV036_RS18695	COG2968	Membrane
HV036_RS18700	COG1279	arginine transmembrane transporter activity
HV036_RS18705	COG0668	transmembrane transport
HV036_RS18710	COG0191	fructose-bisphosphate aldolase activity
HV036_RS18715	COG0126	phosphoglycerate kinase activity
HV036_RS18720	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV036_RS18725	COG1072	(Pantothenic acid kinase))
HV036_RS18735	COG1494	fructose-1,6-bisphosphatase
HV036_RS18740	COG1063	alcohol dehydrogenase
HV036_RS18745	COG2213	PTS system mannitol-specific
HV036_RS18750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS18755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV036_RS18760	COG0501	Belongs to the peptidase M48B family
HV036_RS18775	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HV036_RS18780	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS18785	COG2267	carboxylic ester hydrolase activity
HV036_RS18810	COG1414	Transcriptional regulator
HV036_RS18815	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS18830	COG2146	nitrite reductase [NAD(P)H] activity
HV036_RS18840	COG0010	Belongs to the arginase family
HV036_RS18845	COG1166	arginine decarboxylase activity
HV036_RS18865	COG2814	Major facilitator Superfamily
HV036_RS18870	COG3091	SprT-like family
HV036_RS18875	COG2356	endonuclease I
HV036_RS18880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV036_RS18900	COG2805	Type II/IV secretion system protein
HV036_RS18905	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV036_RS18910	COG0762	integral membrane protein
HV036_RS18915	COG1872	DUF167
HV036_RS18925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV036_RS18930	COG2852	Protein conserved in bacteria
HV036_RS18940	COG3171	Protein conserved in bacteria
HV036_RS18950	COG1194	a g-specific adenine glycosylase
HV036_RS18960	COG0741	lytic transglycosylase activity
HV036_RS18965	COG2211	Major facilitator Superfamily
HV036_RS18970	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HV036_RS18990	COG3052	prosthetic group binding
HV036_RS19000	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV036_RS19005	COG3493	citrate carrier protein
HV036_RS19020	COG1982	Orn Lys Arg decarboxylase major
HV036_RS19025	COG1811	Na channel or pump
HV036_RS19045	COG5002	protein histidine kinase activity
HV036_RS19050	COG2197	response regulator
HV036_RS19070	COG0457	Tetratricopeptide repeat
HV036_RS19075	COG1649	PFAM Uncharacterised BCR, COG1649
HV036_RS19075	COG0726	polysaccharide deacetylase
HV036_RS19080	COG1215	transferase activity, transferring glycosyl groups
HV036_RS19090	COG0754	glutathionylspermidine amidase activity
HV036_RS19095	COG0625	glutathione transferase activity
HV036_RS19100	COG1349	DNA-binding transcription factor activity
HV036_RS19105	COG0840	transmembrane signaling receptor activity
HV036_RS19115	COG0667	Aldo Keto reductase
HV036_RS19120	COG2862	Uncharacterized protein family, UPF0114
HV036_RS19140	COG0848	biopolymer transport protein
HV036_RS19150	COG0626	cystathionine gamma-synthase activity
HV036_RS19155	COG0586	Pfam SNARE associated Golgi protein
HV036_RS19160	COG2207	Transcriptional regulator
HV036_RS19165	COG1979	alcohol dehydrogenase
HV036_RS19210	COG0604	alcohol dehydrogenase
HV036_RS19280	COG0697	spore germination
HV036_RS19285	COG1234	tRNA 3'-trailer cleavage
HV036_RS19295	COG1902	pentaerythritol trinitrate reductase activity
HV036_RS19300	COG0640	Transcriptional regulator
HV036_RS19315	COG3436	PFAM IS66 Orf2 family protein
HV036_RS19320	COG2433	Pfam Transposase IS66
HV036_RS19365	COG0204	Acyl-transferase
HV036_RS19375	COG3111	PFAM Bacterial OB fold (BOF) protein
HV036_RS19390	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV036_RS19395	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV036_RS19400	COG1652	LysM domain
HV036_RS19410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV036_RS19415	COG2211	Major facilitator Superfamily
HV036_RS19440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV036_RS19445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV036_RS19450	COG1120	ATPase activity
HV036_RS19455	COG4774	siderophore transport
HV036_RS19460	COG0187	DNA topoisomerase II activity
HV036_RS19465	COG3150	esterase
HV036_RS19470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV036_RS19475	COG3151	Protein conserved in bacteria
HV036_RS19480	COG0494	nUDIX hydrolase
HV036_RS19495	COG0754	glutathionylspermidine amidase activity
HV036_RS19500	COG3384	dioxygenase
HV036_RS19510	COG3539	Fimbrial protein
HV036_RS19515	COG3188	usher protein
HV036_RS19520	COG3121	Chaperone
HV036_RS19530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HV036_RS19540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HV036_RS19540	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HV036_RS19550	COG3025	triphosphatase activity
HV036_RS19555	COG4991	sh3 domain protein
HV036_RS19560	COG0617	tRNA 3'-terminal CCA addition
HV036_RS19570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV036_RS19580	COG2271	Major facilitator Superfamily
HV036_RS19585	COG0829	nickel cation binding
HV036_RS19590	COG0831	urea catabolic process
HV036_RS19595	COG0832	Belongs to the urease beta subunit family
HV036_RS19600	COG0804	urea catabolic process
HV036_RS19605	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV036_RS19615	COG0830	nickel cation binding
HV036_RS19620	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV036_RS19630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV036_RS19635	COG0358	DNA primase activity
HV036_RS19645	COG3663	DNA glycosylase
HV036_RS19765	COG4387	Mu-like prophage protein GP36
HV036_RS19775	COG4397	Mu-like prophage major head subunit gpT
HV036_RS19785	COG4388	Caudovirus prohead serine protease
HV036_RS19805	COG4383	Mu-like prophage protein gp29
HV036_RS19845	COG3179	chitinase
HV036_RS19920	COG2842	Transposition protein
HV036_RS19930	COG3423	Transcriptional regulator
HV036_RS19950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HV036_RS19955	COG0814	amino acid
HV036_RS19960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV036_RS19965	COG0583	DNA-binding transcription factor activity
HV036_RS19975	COG1929	Belongs to the glycerate kinase type-1 family
HV036_RS19980	COG2084	Dehydrogenase
HV036_RS19990	COG2721	sulfolactate sulfo-lyase activity
HV036_RS19995	COG1349	DNA-binding transcription factor activity
HV036_RS20005	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV036_RS20015	COG3716	PTS system mannose fructose sorbose family IID component
HV036_RS20020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS20025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV036_RS20030	COG2222	sugar isomerase
HV036_RS20035	COG0191	fructose-bisphosphate aldolase activity
HV036_RS20040	COG1263	PTS System
HV036_RS20040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV036_RS20055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV036_RS20060	COG3107	peptidoglycan biosynthetic process
HV036_RS20065	COG0792	nuclease activity
HV036_RS20070	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HV036_RS20075	COG2823	Periplasmic or secreted lipoprotein
HV036_RS20080	COG0701	Predicted permease
HV036_RS20085	COG0702	epimerase
HV036_RS20090	COG0693	protein deglycase activity
HV036_RS20095	COG3787	Belongs to the UPF0306 family
HV036_RS20100	COG2827	Endonuclease containing a URI domain
HV036_RS20105	COG3153	acetyltransferase
HV036_RS20110	COG3154	lipid carrier protein
HV036_RS20115	COG0826	peptidase U32
HV036_RS20120	COG0826	peptidase U32
HV036_RS20125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV036_RS20130	COG0814	amino acid
HV036_RS20135	COG0513	Belongs to the DEAD box helicase family
HV036_RS20150	COG1185	polyribonucleotide nucleotidyltransferase activity
HV036_RS20155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HV036_RS20160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HV036_RS20165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV036_RS20170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV036_RS20190	COG0137	argininosuccinate synthase activity
HV036_RS20200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV036_RS20205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV036_RS20210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV036_RS20220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HV036_RS20225	COG1534	Rna-binding protein
HV036_RS20235	COG2027	D-alanyl-D-alanine carboxypeptidase
HV036_RS20240	COG0745	RESPONSE REGULATOR receiver
HV036_RS20245	COG0642	Histidine kinase
HV036_RS20250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HV036_RS20255	COG0697	spore germination
HV036_RS20265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV036_RS20270	COG0142	geranyltranstransferase activity
HV036_RS20275	COG3423	Transcriptional regulator
HV036_RS20280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HV036_RS20285	COG5007	Belongs to the BolA IbaG family
HV036_RS20290	COG3113	response to antibiotic
HV036_RS20295	COG2854	intermembrane phospholipid transfer
HV036_RS20300	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV036_RS20305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV036_RS20310	COG1127	ABC transporter
HV036_RS20315	COG0530	calcium, potassium:sodium antiporter activity
HV036_RS20325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV036_RS20330	COG3117	lipopolysaccharide transmembrane transporter activity
HV036_RS20335	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV036_RS20340	COG1137	ATPase activity
HV036_RS20345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HV036_RS20365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS20375	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV036_RS20380	COG2198	Histidine kinase
HV036_RS20380	COG0784	Response regulator, receiver
HV036_RS20380	COG5002	protein histidine kinase activity
HV036_RS20385	COG0795	lipopolysaccharide-transporting ATPase activity
HV036_RS20390	COG0795	lipopolysaccharide-transporting ATPase activity
HV036_RS20395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV036_RS20400	COG2927	DNA polymerase III (CHI subunit)
HV036_RS20410	COG0456	acetyltransferase
HV036_RS20415	COG1064	alcohol dehydrogenase
HV036_RS20425	COG0433	COG0433 Predicted ATPase
HV036_RS20430	COG1242	4 iron, 4 sulfur cluster binding
HV036_RS20435	COG0070	glutamate synthase
HV036_RS20435	COG0069	glutamate synthase activity
HV036_RS20435	COG0067	glutamate synthase
HV036_RS20440	COG0493	'glutamate synthase
HV036_RS20445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV036_RS20450	COG0402	S-adenosylhomocysteine deaminase activity
HV036_RS20455	COG3539	Fimbrial protein
HV036_RS20465	COG3188	usher protein
HV036_RS20470	COG3121	Chaperone
HV036_RS20475	COG3539	Fimbrial protein
HV036_RS20480	COG3539	Fimbrial protein
HV036_RS20485	COG2969	positive regulation of protein catabolic process
HV036_RS20490	COG0625	glutathione transferase activity
HV036_RS20495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HV036_RS20505	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV036_RS20510	COG3105	Protein conserved in bacteria
HV036_RS20515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV036_RS20520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV036_RS20530	COG1438	arginine binding
HV036_RS20540	COG2732	(Barnase) inhibitor
HV036_RS20545	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS20550	COG1289	transmembrane transporter activity
HV036_RS20565	COG0583	DNA-binding transcription factor activity
HV036_RS20570	COG0312	modulator of DNA gyrase
HV036_RS20575	COG3164	Protein of unknown function
HV036_RS20580	COG1530	ribonuclease E activity
HV036_RS20590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV036_RS20595	COG1792	Involved in formation and maintenance of cell shape
HV036_RS20600	COG1077	Cell shape determining protein MreB Mrl
HV036_RS20605	COG2199	diguanylate cyclase activity
HV036_RS20605	COG2200	EAL domain
HV036_RS20610	COG0604	alcohol dehydrogenase
HV036_RS20620	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HV036_RS20625	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HV036_RS20630	COG0511	ligase activity, forming carbon-carbon bonds
HV036_RS20635	COG0439	Biotin carboxylase
HV036_RS20640	COG3924	membrane
HV036_RS20645	COG4145	pantothenate transmembrane transporter activity
HV036_RS20680	COG1309	transcriptional regulator
HV036_RS20685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS20690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV036_RS20730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV036_RS20740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV036_RS20745	COG0009	L-threonylcarbamoyladenylate synthase
HV036_RS20750	COG0551	DNA topoisomerase type I activity
HV036_RS20755	COG2922	Belongs to the Smg family
HV036_RS20760	COG0758	DNA mediated transformation
HV036_RS20765	COG0242	peptide deformylase activity
HV036_RS20770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HV036_RS20775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HV036_RS20775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HV036_RS20785	COG1970	mechanosensitive ion channel activity
HV036_RS20790	COG3036	rescue of stalled ribosome
HV036_RS20795	COG0789	Transcriptional regulator
HV036_RS20810	COG0202	RNA polymerase activity
HV036_RS20820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV036_RS20835	COG0201	protein transport
HV036_RS20845	COG1841	ribosomal large subunit assembly
HV036_RS20860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HV036_RS20865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HV036_RS20895	COG0255	Belongs to the universal ribosomal protein uL29 family
HV036_RS20900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HV036_RS20940	COG0051	transcription antitermination factor activity, RNA binding
HV036_RS20980	COG2168	tRNA wobble position uridine thiolation
HV036_RS20985	COG2923	Belongs to the DsrF TusC family
HV036_RS20990	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV036_RS20995	COG2964	Protein conserved in bacteria
HV036_RS21000	COG0545	Peptidyl-prolyl cis-trans isomerase
HV036_RS21005	COG2900	Belongs to the SlyX family
HV036_RS21010	COG1047	Peptidyl-prolyl cis-trans
HV036_RS21015	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV036_RS21020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV036_RS21020	COG0475	glutathione-regulated potassium exporter activity
HV036_RS21025	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV036_RS21030	COG0488	(ABC) transporter
HV036_RS21040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV036_RS21050	COG0679	Auxin Efflux Carrier
HV036_RS21080	COG0429	hydrolase of the alpha beta-hydrolase fold
HV036_RS21085	COG3089	Belongs to the UPF0270 family
HV036_RS21090	COG3954	Phosphoribulokinase
HV036_RS21095	COG1765	OsmC-like protein
HV036_RS21105	COG1289	transmembrane transporter activity
HV036_RS21110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV036_RS21115	COG0512	Glutamine amidotransferase of anthranilate synthase
HV036_RS21120	COG2184	nucleotidyltransferase activity
HV036_RS21130	COG0738	Major facilitator superfamily
HV036_RS21135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV036_RS21145	COG1648	precorrin-2 dehydrogenase activity
HV036_RS21145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV036_RS21155	COG0180	Tryptophanyl-tRNA synthetase
HV036_RS21165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV036_RS21170	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV036_RS21175	COG3266	domain, Protein
HV036_RS21180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HV036_RS21185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV036_RS21210	COG4972	Pilus assembly protein
HV036_RS21215	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV036_RS21220	COG0494	nUDIX hydrolase
HV036_RS21230	COG1011	Hydrolase
HV036_RS21235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV036_RS21240	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HV036_RS21245	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV036_RS21250	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HV036_RS21260	COG0745	RESPONSE REGULATOR receiver
HV036_RS21265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV036_RS21270	COG2183	response to ionizing radiation
HV036_RS21275	COG1918	ferrous iron import across plasma membrane
HV036_RS21295	COG1040	competence protein
HV036_RS21305	COG2610	gluconate transmembrane transporter activity
HV036_RS21310	COG1640	4-alpha-glucanotransferase
HV036_RS21315	COG0058	SHG alpha-glucan phosphorylase activity
HV036_RS21320	COG2909	trisaccharide binding
HV036_RS21325	COG1349	DNA-binding transcription factor activity
HV036_RS21330	COG0705	Rhomboid family
HV036_RS21335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV036_RS21340	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV036_RS21345	COG0058	SHG alpha-glucan phosphorylase activity
HV036_RS21350	COG0297	glycogen (starch) synthase activity
HV036_RS21355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HV036_RS21360	COG1523	belongs to the glycosyl hydrolase 13 family
HV036_RS21365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HV036_RS21370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV036_RS21375	COG2095	MarC family integral membrane protein
HV036_RS21380	COG2610	gluconate transmembrane transporter activity
HV036_RS21385	COG3265	gluconokinase activity
HV036_RS21390	COG1609	Transcriptional regulator
HV036_RS21395	COG1741	Belongs to the pirin family
HV036_RS21400	COG0673	inositol 2-dehydrogenase activity
HV036_RS21405	COG1247	-acetyltransferase
HV036_RS21410	COG0405	Gamma-glutamyltransferase
HV036_RS21420	COG0584	glycerophosphoryl diester phosphodiesterase
HV036_RS21450	COG0411	ABC transporter
HV036_RS21465	COG0683	leucine binding
HV036_RS21475	COG0683	leucine binding
HV036_RS21480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV036_RS21485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV036_RS21490	COG2177	Part of the ABC transporter FtsEX involved in
HV036_RS21495	COG2884	Cell division ATP-binding protein ftsE
HV036_RS21500	COG0552	protein localization to endoplasmic reticulum
HV036_RS21505	COG0742	ribosomal rna small subunit methyltransferase
HV036_RS21510	COG3776	membrane
HV036_RS21520	COG3714	YhhN family
HV036_RS21525	COG2217	Heavy metal translocating P-type atpase
HV036_RS21540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV036_RS21545	COG0425	Belongs to the sulfur carrier protein TusA family
HV036_RS21550	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV036_RS21560	COG0628	permease
HV036_RS21580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV036_RS21600	COG1216	Glycosyl transferase, family 2
HV036_RS21625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV036_RS21635	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS21640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV036_RS21650	COG3479	Phenolic acid decarboxylase
HV036_RS21655	COG0583	DNA-binding transcription factor activity
HV036_RS21660	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS21680	COG2205	protein histidine kinase activity
HV036_RS21685	COG0745	RESPONSE REGULATOR receiver
HV036_RS21690	COG1276	copper resistance
HV036_RS21695	COG2372	response to copper ion
HV036_RS21700	COG3667	copper resistance
HV036_RS21705	COG2132	Multicopper oxidase
HV036_RS21715	COG0739	heme binding
HV036_RS21745	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV036_RS21810	COG2081	HI0933 family
HV036_RS21815	COG0306	phosphate transporter
HV036_RS21825	COG0589	response to stress
HV036_RS21830	COG0742	ribosomal rna small subunit methyltransferase
HV036_RS21835	COG0339	signal peptide processing
HV036_RS21840	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV036_RS21845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV036_RS21860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV036_RS21870	COG2197	response regulator
HV036_RS21875	COG1028	Short-chain dehydrogenase reductase Sdr
HV036_RS21880	COG0583	DNA-binding transcription factor activity
HV036_RS21885	COG1295	ribonuclease BN
HV036_RS21890	COG0477	Major facilitator Superfamily
HV036_RS21895	COG2982	Protein involved in outer membrane biogenesis
HV036_RS21900	COG2200	EAL domain
HV036_RS21910	COG0612	Peptidase, M16
HV036_RS21915	COG1301	dicarboxylic acid transport
HV036_RS21920	COG2199	diguanylate cyclase activity
HV036_RS21920	COG2200	EAL domain
HV036_RS21925	COG0457	Tetratricopeptide repeat
HV036_RS21925	COG3118	belongs to the thioredoxin family
HV036_RS21930	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HV036_RS21935	COG1215	transferase activity, transferring glycosyl groups
HV036_RS21940	COG1215	transferase activity, transferring glycosyl groups
HV036_RS21965	COG2194	sulfuric ester hydrolase activity
HV036_RS21975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV036_RS22005	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HV036_RS22015	COG1739	Uncharacterized protein family UPF0029
HV036_RS22020	COG0006	proline dipeptidase activity
HV036_RS22025	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV036_RS22025	COG1024	Enoyl-CoA hydratase
HV036_RS22030	COG0183	Belongs to the thiolase family
HV036_RS22035	COG0751	glycine-tRNA ligase activity
HV036_RS22040	COG0752	glycyl-tRNA synthetase alpha subunit
HV036_RS22050	COG3274	enterobacterial common antigen metabolic process
HV036_RS22055	COG1070	Carbohydrate kinase
HV036_RS22060	COG2115	Belongs to the xylose isomerase family
HV036_RS22065	COG4213	ABC transporter substrate-binding protein
HV036_RS22075	COG4214	carbohydrate transport
HV036_RS22080	COG2207	Transcriptional regulator
HV036_RS22080	COG1609	Transcriptional regulator
HV036_RS22085	COG2992	FlgJ-related protein
HV036_RS22090	COG0366	Alpha amylase catalytic
HV036_RS22095	COG3977	Valine--pyruvate aminotransferase
HV036_RS22100	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV036_RS22110	COG2211	Major facilitator Superfamily
HV036_RS22120	COG1012	belongs to the aldehyde dehydrogenase family
HV036_RS22125	COG1940	carbohydrate kinase activity
HV036_RS22130	COG3276	selenocysteine insertion sequence binding
HV036_RS22140	COG0625	glutathione transferase activity
HV036_RS22145	COG2213	PTS system mannitol-specific
HV036_RS22145	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV036_RS22155	COG3722	fumarate hydratase activity
HV036_RS22170	COG3188	usher protein
HV036_RS22175	COG3121	Chaperone
HV036_RS22180	COG3539	Fimbrial protein
HV036_RS22190	COG2186	Transcriptional regulator
HV036_RS22195	COG1304	FMN binding
HV036_RS22200	COG2271	Major facilitator Superfamily
HV036_RS22205	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV036_RS22215	COG0583	DNA-binding transcription factor activity
HV036_RS22220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV036_RS22230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV036_RS22235	COG3978	acetolactate synthase activity
HV036_RS22255	COG3085	chromosome segregation
HV036_RS22305	COG4206	TonB-dependent receptor
HV036_RS22310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV036_RS22330	COG0583	DNA-binding transcription factor activity
HV036_RS22335	COG0165	Argininosuccinate lyase
HV036_RS22345	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HV036_RS22350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV036_RS22355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HV036_RS22360	COG2207	Transcriptional regulator
HV036_RS22370	COG0371	Dehydrogenase
HV036_RS22375	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HV036_RS22380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV036_RS22385	COG0527	aspartate kinase activity
HV036_RS22385	COG0460	homoserine dehydrogenase
HV036_RS22390	COG0626	cystathionine gamma-synthase activity
HV036_RS22400	COG0254	rRNA binding
HV036_RS22405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV036_RS22410	COG1609	Transcriptional regulator
HV036_RS22415	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV036_RS22430	COG1575	Belongs to the MenA family. Type 1 subfamily
HV036_RS22440	COG3074	FtsZ-dependent cytokinesis
HV036_RS22445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV036_RS22450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV036_RS22455	COG1494	fructose-1,6-bisphosphatase
HV036_RS22465	COG3152	Membrane
HV036_RS22475	COG0149	triose-phosphate isomerase activity
HV036_RS22485	COG2134	cdp-diacylglycerol pyrophosphatase
HV036_RS22495	COG0205	6-phosphofructokinase activity
HV036_RS22505	COG3678	ATP-independent chaperone mediated protein folding
HV036_RS22510	COG0745	RESPONSE REGULATOR receiver
HV036_RS22515	COG2205	protein histidine kinase activity
HV036_RS22520	COG2258	MOSC domain
HV036_RS22525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV036_RS22535	COG4977	sequence-specific DNA binding
HV036_RS22535	COG1917	Cupin 2, conserved barrel domain protein
HV036_RS22540	COG4977	sequence-specific DNA binding
HV036_RS22545	COG1070	Carbohydrate kinase
HV036_RS22550	COG4806	L-rhamnose isomerase
HV036_RS22555	COG0235	Class ii aldolase
HV036_RS22565	COG1129	ABC transporter
HV036_RS22570	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS22580	COG1454	alcohol dehydrogenase
HV036_RS22585	COG3254	rhamnose metabolic process
HV036_RS22590	COG2211	Major facilitator Superfamily
HV036_RS22610	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV036_RS22635	COG0437	4 iron, 4 sulfur cluster binding
HV036_RS22640	COG2864	formate dehydrogenase
HV036_RS22655	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV036_RS22665	COG0456	acetyltransferase
HV036_RS22680	COG1011	Hydrolase
HV036_RS22685	COG1349	DNA-binding transcription factor activity
HV036_RS22690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV036_RS22700	COG3684	Belongs to the aldolase LacD family
HV036_RS22710	COG1501	Belongs to the glycosyl hydrolase 31 family
HV036_RS22725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV036_RS22740	COG3852	Histidine kinase
HV036_RS22755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV036_RS22760	COG3078	GTPase activator activity
HV036_RS22780	COG0204	Acyl-transferase
HV036_RS22790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HV036_RS22795	COG3084	Protein conserved in bacteria
HV036_RS22800	COG0746	molybdenum cofactor guanylyltransferase activity
HV036_RS22805	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV036_RS22830	COG2186	Transcriptional regulator
HV036_RS22835	COG0477	Major facilitator Superfamily
HV036_RS22840	COG1609	Transcriptional regulator
HV036_RS22845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV036_RS22855	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS22860	COG1129	ABC transporter
HV036_RS22865	COG1869	D-ribose catabolic process
HV036_RS22870	COG3158	transport of potassium into the cell
HV036_RS22880	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HV036_RS22885	COG2502	aspartate--ammonia ligase
HV036_RS22890	COG1522	sequence-specific DNA binding
HV036_RS22895	COG0716	FMN binding
HV036_RS22900	COG0445	tRNA wobble uridine modification
HV036_RS22905	COG0357	Ribosomal RNA small subunit methyltransferase G
HV036_RS22910	COG3312	ion transport
HV036_RS22915	COG0356	it plays a direct role in the translocation of protons across the membrane
HV036_RS22925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HV036_RS22930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HV036_RS22935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV036_RS22945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV036_RS22950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV036_RS22955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV036_RS22965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV036_RS22970	COG0573	inorganic phosphate transmembrane transporter activity
HV036_RS22975	COG0581	inorganic phosphate transmembrane transporter activity
HV036_RS22980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HV036_RS22985	COG0704	Plays a role in the regulation of phosphate uptake
HV036_RS22990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV036_RS22995	COG2252	PERMEase
HV036_RS23000	COG0431	NADPH-dependent FMN reductase
HV036_RS23005	COG2091	lysine biosynthetic process via aminoadipic acid
HV036_RS23025	COG0706	membrane insertase activity
HV036_RS23085	COG2205	protein histidine kinase activity
HV036_RS23090	COG0745	RESPONSE REGULATOR receiver
HV036_RS23095	COG1276	copper resistance
HV036_RS23100	COG2372	response to copper ion
HV036_RS23125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HV036_RS23130	COG1902	pentaerythritol trinitrate reductase activity
HV036_RS23135	COG3118	belongs to the thioredoxin family
HV036_RS23140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV036_RS23195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV036_RS23270	COG2433	Pfam Transposase IS66
HV036_RS23275	COG3436	PFAM IS66 Orf2 family protein
HV036_RS23305	COG3039	Transposase
HV036_RS23310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV036_RS23315	COG0698	ribose 5-phosphate isomerase
HV036_RS23320	COG1263	PTS System
HV036_RS23320	COG2190	(PTS) system
HV036_RS23320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV036_RS23325	COG1737	Transcriptional regulator
HV036_RS23465	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS23470	COG1129	ABC transporter
HV036_RS23480	COG1609	Transcriptional regulator
HV036_RS23485	COG3039	Transposase
HV036_RS23515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV036_RS23515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV036_RS23535	COG1278	Cold shock
HV036_RS23565	COG4644	lycopene metabolic process
HV036_RS23575	COG0583	DNA-binding transcription factor activity
HV036_RS23590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV036_RS23595	COG0625	glutathione transferase activity
HV036_RS23680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV036_RS23750	COG2223	nitrite transmembrane transporter activity
HV036_RS23760	COG1609	Transcriptional regulator
HV036_RS23790	COG3436	PFAM IS66 Orf2 family protein
HV036_RS23795	COG1120	ATPase activity
HV036_RS23800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV036_RS23805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV036_RS23810	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV036_RS23815	COG4772	TonB-dependent receptor
HV036_RS23820	COG3712	iron ion homeostasis
HV036_RS23825	COG1595	DNA-templated transcription, initiation
HV036_RS23845	COG4974	Belongs to the 'phage' integrase family
HV036_RS23870	COG4245	von Willebrand factor, type A
HV036_RS23875	COG4245	von Willebrand factor, type A
HV036_RS23905	COG1358	cellular component organization or biogenesis
HV036_RS23990	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV036_RS23995	COG4575	ribosome binding
HV036_RS24000	COG1422	Protein of unknown function (DUF1090)
HV036_RS24010	COG0586	Pfam SNARE associated Golgi protein
HV036_RS24015	COG2186	Transcriptional regulator
HV036_RS24020	COG2271	Major facilitator Superfamily
HV036_RS24030	COG2721	sulfolactate sulfo-lyase activity
HV036_RS24040	COG0861	Integral membrane protein TerC family
HV036_RS24045	COG0673	inositol 2-dehydrogenase activity
HV036_RS24050	COG1451	nucleotide metabolic process
HV036_RS24060	COG1902	pentaerythritol trinitrate reductase activity
HV036_RS24060	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV036_RS24065	COG1070	Carbohydrate kinase
HV036_RS24070	COG2390	Transcriptional regulator
HV036_RS24075	COG1129	ABC transporter
HV036_RS24080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS24085	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV036_RS24090	COG1879	ABC-type sugar transport system periplasmic component
HV036_RS24095	COG1830	Aldolase
HV036_RS24100	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV036_RS24105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV036_RS24110	COG0840	transmembrane signaling receptor activity
HV036_RS24115	COG0840	transmembrane signaling receptor activity
HV036_RS24120	COG1695	Transcriptional regulator
HV036_RS24125	COG2375	cellular response to nickel ion
HV036_RS24165	COG4974	Belongs to the 'phage' integrase family
HV036_RS24200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV036_RS24220	COG4695	Portal protein
HV036_RS24330	COG0814	amino acid
HV036_RS24340	COG1741	Belongs to the pirin family
HV036_RS24345	COG0583	DNA-binding transcription factor activity
HV036_RS24350	COG3152	Membrane
HV036_RS24355	COG0435	Glutathione S-transferase