locus-tag class description HV128_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HV128_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HV128_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV128_RS00025 ENOG4105CC0 LysR family Transcriptional regulator HV128_RS00035 ENOG410667J hydrolase HV128_RS00040 ENOG4105EMF GntR family transcriptional regulator HV128_RS00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HV128_RS00050 ENOG4108RTU Aldolase HV128_RS00055 ENOG4105CXK mandelate racemase muconate lactonizing HV128_RS00060 ENOG4105DJB Major Facilitator Superfamily HV128_RS00065 ENOG4105D99 atp gtp-binding protein HV128_RS00070 ENOG4105R2A (LipO)protein HV128_RS00080 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HV128_RS00085 ENOG4105D0C transport protein HV128_RS00090 ENOG4105FDP GntR family transcriptional regulator HV128_RS00095 ENOG4105CI1 PTS System HV128_RS00100 ENOG4105F8D glycoside hydrolase family 4 HV128_RS00105 ENOG4105VG5 Membrane HV128_RS00110 ENOG4105JP4 Inner membrane protein yidG HV128_RS00125 ENOG4105E5M Multidrug resistance protein D HV128_RS00150 ENOG4108Z3N Transcriptional regulator HV128_RS00160 ENOG4105C7K acetolactate synthase HV128_RS00165 ENOG4105M71 acetolactate synthase 1 regulatory subunit HV128_RS00170 ENOG4108KX4 response regulator HV128_RS00175 ENOG4105BZU Histidine kinase HV128_RS00180 ENOG4105CXY transporter HV128_RS00185 ENOG4105CXY transporter HV128_RS00200 ENOG4108SAJ Protein of unknown function (DUF1198) HV128_RS00215 ENOG4108UZ3 Transporter HV128_RS00220 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HV128_RS00225 ENOG4105VCP PTS System HV128_RS00240 ENOG4106H6R UPF0380 protein HV128_RS00245 ENOG4108XS9 dna repair protein HV128_RS00250 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV128_RS00255 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HV128_RS00290 ENOG4105ECQ AraC Family Transcriptional Regulator HV128_RS00310 ENOG4108RQP Major type 1 subunit fimbrin HV128_RS00315 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HV128_RS00320 ENOG4105CW0 outer membrane usher protein HV128_RS00345 ENOG4105VT2 5-hydroxyisourate hydrolase HV128_RS00350 ENOG4107SEY Conserved Protein HV128_RS00355 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HV128_RS00365 ENOG4105KRQ Addiction module toxin, Txe YoeB family HV128_RS00370 ENOG4105VTW prevent-host-death family HV128_RS00375 ENOG4108MBX Secretion Protein HV128_RS00385 ENOG4108JJA ABC, transporter HV128_RS00410 ENOG4108N3D putative enzyme HV128_RS00440 ENOG4108MQF Chaperone HV128_RS00445 ENOG4105CW0 outer membrane usher protein HV128_RS00470 ENOG4105D01 (LipO)protein HV128_RS00480 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HV128_RS00495 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HV128_RS00500 ENOG4105VEV -acetyltransferase HV128_RS00505 ENOG41067SE Tetr family transcriptional regulator HV128_RS00510 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV128_RS00515 ENOG4105BZS acriflavin resistance protein HV128_RS00520 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HV128_RS00525 ENOG4105C2C drug resistance transporter, Bcr CflA HV128_RS00535 ENOG4105ETE Transcriptional regulator (LacI family HV128_RS00545 ENOG4105CK1 PTS System HV128_RS00570 ENOG4105CT4 transporter HV128_RS00575 ENOG4105CJQ hydrolase, family 31 HV128_RS00580 ENOG4105JV1 AsmA family HV128_RS00585 ENOG4105C2W permease HV128_RS00590 ENOG4105D6U Sodium Glutamate Symporter HV128_RS00595 ENOG4105CB5 ATP-dependent DNA helicase recG HV128_RS00600 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HV128_RS00605 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV128_RS00620 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HV128_RS00630 ENOG4108Y9B (LipO)protein HV128_RS00635 ENOG4108W78 Pfam:DUF1017 HV128_RS00640 ENOG4105E3R (LipO)protein HV128_RS00645 ENOG4105DAY polysaccharide export protein HV128_RS00650 ENOG4107ZF2 Phosphatase HV128_RS00655 ENOG4108F2G Chain length determinant protein HV128_RS00660 ENOG4105EN6 Membrane HV128_RS00665 ENOG4105DSJ YicC domain protein HV128_RS00670 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HV128_RS00675 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HV128_RS00685 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HV128_RS00690 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HV128_RS00695 ENOG4105W5Q DNA repair protein (RadC HV128_RS00700 ENOG4105KDC 50s ribosomal protein l28 HV128_RS00705 ENOG4105W0E 50S ribosomal protein L33 HV128_RS00710 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HV128_RS00715 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HV128_RS00720 ENOG4106WTF Glycosyl transferase, family 2 HV128_RS00725 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HV128_RS00730 ENOG4105K64 Glycosyl transferase, family 2 HV128_RS00735 ENOG4105CPK Glycosyl transferase (Group 1 HV128_RS00745 ENOG4105DKP glycosyl transferase, family 9 HV128_RS00755 ENOG4107R51 Glycosyl transferase, family 2 HV128_RS00765 ENOG4105D16 lipopolysaccharide heptosyltransferase i HV128_RS00770 ENOG4105XA0 heptosyltransferase ii HV128_RS00775 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HV128_RS00780 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV128_RS00785 ENOG4105CPQ Dehydrogenase HV128_RS00795 ENOG4107TAE Glycosyl transferase (Group 1 HV128_RS00800 ENOG4106WTF Glycosyl transferase, family 2 HV128_RS00805 ENOG4105PXI polysaccharide deacetylase HV128_RS00810 ENOG41063SB peptidase HV128_RS00815 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HV128_RS00820 ENOG4107YZP Rhodanese domain protein HV128_RS00825 ENOG4105VW4 glutaredoxin 3 HV128_RS00830 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HV128_RS00835 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HV128_RS00840 ENOG4105D7W serine acetyltransferase HV128_RS00845 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HV128_RS00850 ENOG4105C4R Atp-dependent dna helicase HV128_RS00855 ENOG4105C9X ppx gppa phosphatase HV128_RS00870 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HV128_RS00875 ENOG4105ESV Glycosyl transferase, family 4 HV128_RS00880 ENOG4105SFE lipopolysaccharide biosynthesis protein HV128_RS00885 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HV128_RS00890 ENOG4107QQG Dehydrogenase HV128_RS00895 ENOG4108WJ1 acetyltransferase HV128_RS00900 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HV128_RS00905 ENOG4105EGZ biosynthesis protein HV128_RS00910 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HV128_RS00915 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HV128_RS00920 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HV128_RS00925 ENOG4105C85 amino acid HV128_RS00955 ENOG410601J HemY protein HV128_RS00960 ENOG4105ECF c-methyltransferase HV128_RS00965 ENOG41076E6 Uroporphyrinogen-III Synthase HV128_RS00970 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HV128_RS00975 ENOG4107T0K Adenylate cyclase HV128_RS00980 ENOG4105XQ6 frataxin-like protein HV128_RS00985 ENOG4105S7Z (LipO)protein HV128_RS00995 ENOG4105CT0 Protein of unknown function, DUF484 HV128_RS01000 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV128_RS01005 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HV128_RS01010 ENOG4105C4R Atp-dependent dna helicase HV128_RS01015 ENOG4107QUT magnesium and cobalt transport protein CorA HV128_RS01020 ENOG4105FR1 rard protein HV128_RS01025 ENOG4108VUY thioesterase Superfamily protein HV128_RS01030 ENOG4105F9F transposase HV128_RS01035 ENOG4105HDD phospholipase HV128_RS01040 ENOG4105C9U ATP-dependent DNA helicase RecQ HV128_RS01045 ENOG4105CCF Lysine exporter protein (Lyse ygga) HV128_RS01050 ENOG410829K Lysine exporter protein (Lyse ygga) HV128_RS01055 ENOG4108EUD Lysophospholipase HV128_RS01060 ENOG4105DQF Hydrolase HV128_RS01065 ENOG4105EMK carboxylate amino acid amine transporter HV128_RS01070 ENOG4105DZ2 Transcriptional regulator HV128_RS01080 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HV128_RS01085 ENOG4107SXA Phosphorylase HV128_RS01090 ENOG4105CGY Dna recombination protein HV128_RS01095 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HV128_RS01100 ENOG4105JC1 sterol-binding domain protein HV128_RS01105 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HV128_RS01110 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HV128_RS01115 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HV128_RS01120 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HV128_RS01125 ENOG4105F8V Hydrolase, tatD family HV128_RS01130 ENOG4105MDZ Transcriptional activator rfaH HV128_RS01135 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV128_RS01140 ENOG4107QK7 reductase HV128_RS01145 ENOG4105C5H ABC transporter HV128_RS01150 ENOG4105MVF Transcriptional regulator HV128_RS01155 ENOG4106JH6 (LipO)protein HV128_RS01165 ENOG4105C5I Dehydrogenase HV128_RS01175 ENOG4105D7K pfkb domain protein HV128_RS01185 ENOG4108M60 Transcriptional regulator HV128_RS01190 ENOG4108ZG0 Ompa motb domain protein HV128_RS01195 ENOG4107QY8 reductase HV128_RS01200 ENOG4105HNP -acetyltransferase HV128_RS01205 ENOG4108R3E Dna-3-methyladenine glycosylase i HV128_RS01210 ENOG4105EAX Putative lipase HV128_RS01215 ENOG4105FCD Major Facilitator HV128_RS01220 ENOG4106EAR Fimbrial protein HV128_RS01225 ENOG4108VCD Chaperone HV128_RS01230 ENOG4105CW0 outer membrane usher protein HV128_RS01235 ENOG4105MHR Fimbrial protein HV128_RS01240 ENOG4106UCC Fimbrial protein HV128_RS01245 ENOG4105DIJ Phosphoethanolamine transferase HV128_RS01255 ENOG4105DEF Extracellular solute-binding protein, family 5 HV128_RS01260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV128_RS01265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV128_RS01270 ENOG4105C3U ABC transporter HV128_RS01275 ENOG4108JQ7 (ABC) transporter HV128_RS01280 ENOG4105CS9 pantothenic acid kinase HV128_RS01305 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HV128_RS01310 ENOG4105PM1 preprotein translocase subunit SecE HV128_RS01315 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HV128_RS01330 ENOG4108VZM 50s ribosomal protein L10 HV128_RS01340 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV128_RS01345 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV128_RS01360 ENOG4106TD9 Diguanylate cyclase HV128_RS01365 ENOG4105D41 biosynthesis protein thiH HV128_RS01370 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HV128_RS01375 ENOG4105WHD thiamine biosynthesis protein ThiS HV128_RS01380 ENOG4105D06 uba thif-type nad fad binding protein HV128_RS01390 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HV128_RS01395 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HV128_RS01405 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HV128_RS01410 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HV128_RS01415 ENOG4105R2J Conserved Protein HV128_RS01420 ENOG4105K70 DNA-binding protein HV128_RS01425 ENOG4108T8B Protein of unknown function (DUF1481) HV128_RS01430 ENOG4105C12 Phosphoribosylglycinamide synthetase HV128_RS01435 ENOG4105DC1 bifunctional purine biosynthesis protein purh HV128_RS01455 ENOG4105CVG Homoserine O-transsuccinylase HV128_RS01460 ENOG4107QP3 malate synthase g HV128_RS01465 ENOG4108I9X Isocitrate lyase HV128_RS01470 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HV128_RS01475 ENOG41069M3 Transcriptional regulator HV128_RS01480 ENOG4105C3R Methionine synthase HV128_RS01485 ENOG4105EAM Na Pi-cotransporter HV128_RS01490 ENOG4105YES addiction module antidote protein HV128_RS01495 ENOG4105VUH addiction module killer protein HV128_RS01500 ENOG4105FE9 pseudouridine synthase HV128_RS01505 ENOG4108ZR5 Conserved Protein HV128_RS01510 ENOG4105C09 Bile acid HV128_RS01515 ENOG4105CFH Aspartokinase HV128_RS01530 ENOG4108MDC (LipO)protein HV128_RS01535 ENOG4108Q9C Periplasmic Protein HV128_RS01540 ENOG4105E3R (LipO)protein HV128_RS01545 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HV128_RS01550 ENOG4105EG2 ABC transporter, permease HV128_RS01555 ENOG4105D56 permease protein HV128_RS01560 ENOG4107FKK extracellular solute-binding protein family 1 HV128_RS01565 ENOG4108IJ9 (ABC) transporter HV128_RS01570 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HV128_RS01575 ENOG4107W52 maltose operon periplasmic protein HV128_RS01580 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HV128_RS01585 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HV128_RS01590 ENOG4105E55 glycerol-3-phosphate acyltransferase HV128_RS01595 ENOG41080IJ Diacylglycerol kinase HV128_RS01600 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HV128_RS01605 ENOG4107R73 Mate efflux family protein HV128_RS01610 ENOG4105VDW Csbd family HV128_RS01615 ENOG4105MYN Zinc uptake regulation protein HV128_RS01630 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV128_RS01635 ENOG4105P4Z Phage shock protein G HV128_RS01640 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HV128_RS01645 ENOG4105CDU Replicative dna helicase HV128_RS01650 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV128_RS01655 ENOG4105CGF Aromatic amino acid aminotransferase HV128_RS01660 ENOG4105F0S class B acid phosphatase HV128_RS01665 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HV128_RS01670 ENOG4105MSB protein, conserved in bacteria HV128_RS01675 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HV128_RS01680 ENOG4108UUM single-stranded DNA-binding protein HV128_RS01685 ENOG4105PMV Membrane HV128_RS01695 ENOG4108M8H domain protein HV128_RS01700 ENOG4108W3Q Transcriptional regulator HV128_RS01705 ENOG4108Z4X TRANSCRIPTIONal HV128_RS01710 ENOG4108K3A Glutathione S-transferase HV128_RS01715 ENOG4105C7N Xanthine uracil vitamin C permease HV128_RS01720 ENOG4105EEQ Na H antiporter HV128_RS01725 ENOG4105CMU LysR family (Transcriptional regulator HV128_RS01730 ENOG4105VAW lrga family HV128_RS01735 ENOG41067MG lrgb family HV128_RS01740 ENOG4107QN1 sodium solute HV128_RS01745 ENOG41062QD Membrane HV128_RS01750 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV128_RS01755 ENOG4105CK2 sodium dicarboxylate symporter HV128_RS01760 ENOG41082ND Uncharacterized protein yjcO HV128_RS01765 ENOG41074AV Hok/gef family HV128_RS01785 ENOG4105D2N Aldolase HV128_RS01795 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV128_RS01800 ENOG4105CNN ABC, transporter HV128_RS01805 ENOG4105C2J ABC transporter HV128_RS01810 ENOG4105BZU Histidine kinase HV128_RS01820 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HV128_RS01825 ENOG410849A acetyltransferase, (GNAT) family HV128_RS01830 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HV128_RS01835 ENOG4105FD8 phosphonate metabolism protein PhnM HV128_RS01840 ENOG4105HRV phosphonate c-p lyase system protein phnl HV128_RS01845 ENOG4105ENV phosphonate C-P lyase system protein PhnK HV128_RS01850 ENOG4105FT8 Phosphonate metabolism HV128_RS01855 ENOG4105EKV Phosphonate metabolism protein HV128_RS01860 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HV128_RS01865 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HV128_RS01870 ENOG4107RJJ Transcriptional regulator HV128_RS01880 ENOG4105EHI Phosphonate ABC transporter, periplasmic HV128_RS01885 ENOG4105D5T phosphonate abc transporter HV128_RS01890 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HV128_RS01895 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HV128_RS01900 ENOG4108F5E vimentin HV128_RS01905 ENOG4108YIV HV128_RS01910 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HV128_RS01915 ENOG4105CSH Transporter HV128_RS01920 ENOG4105D7X high-affinity nickel-transporter HV128_RS01955 ENOG4105XCM membrane LIPOPROTEIN HV128_RS01960 ENOG4105BZS acriflavin resistance protein HV128_RS01965 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV128_RS01970 ENOG4108XG4 DNA-binding transcriptional regulator HV128_RS01975 ENOG4105BZU Histidine kinase HV128_RS01980 ENOG41061ME transport protein HV128_RS01990 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV128_RS02005 ENOG4108IA2 Sodium pantothenate symporter HV128_RS02010 ENOG4105RG0 Membrane HV128_RS02015 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HV128_RS02020 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HV128_RS02025 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HV128_RS02030 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HV128_RS02040 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HV128_RS02045 ENOG41062P1 Diguanylate cyclase phosphodiesterase HV128_RS02055 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HV128_RS02060 ENOG4105VQ7 Rod shape-determining protein MreD HV128_RS02070 ENOG4105C03 ribonuclease HV128_RS02075 ENOG4105QD6 exported protein HV128_RS02080 ENOG4105D1U peptidase U62 modulator of DNA gyrase HV128_RS02085 ENOG4105R3P Inner membrane protein yagU HV128_RS02090 ENOG4105CR8 Transcriptional regulator HV128_RS02095 ENOG4105ZQC membrane protein AaeX HV128_RS02105 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HV128_RS02110 ENOG4105C26 Dehydrogenase HV128_RS02115 ENOG4105UNR (Barnase) inhibitor HV128_RS02120 ENOG4105RID UPF0379 protein yhcN HV128_RS02125 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HV128_RS02135 ENOG4105C0H protease HV128_RS02140 ENOG4105C0H protease HV128_RS02145 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HV128_RS02150 ENOG4105D6Z AFG1 family ATPase HV128_RS02160 ENOG4108UJD 30S ribosomal protein S9 HV128_RS02165 ENOG4107MKT Stringent starvation protein a HV128_RS02170 ENOG4105KB2 stringent starvation protein b HV128_RS02175 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon HV128_RS02180 ENOG4108S1B Periplasmic chaperone protein HV128_RS02185 ENOG4105E6S usher protein( HV128_RS02195 ENOG4105UMR response to DNA damage stimulus HV128_RS02200 ENOG4105BZ8 glutamate synthase HV128_RS02205 ENOG4105CBC glutamate synthase HV128_RS02210 ENOG4105N5T Radical SAM Protein HV128_RS02215 ENOG4105D7A ATP-binding protein HV128_RS02225 ENOG4105DQ4 alcohol dehydrogenase HV128_RS02230 ENOG4108MJ3 acetyltransferase HV128_RS02235 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HV128_RS02240 ENOG4105MYG DNA polymerase iii, chi subunit HV128_RS02245 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV128_RS02250 ENOG4108M8S permease YjgP YjgQ family protein HV128_RS02255 ENOG4108K5H permease YjgP YjgQ family protein HV128_RS02260 ENOG4105BZU Histidine kinase HV128_RS02265 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HV128_RS02270 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HV128_RS02275 ENOG41080Z8 PHOSPHOCARRIER protein HV128_RS02280 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HV128_RS02285 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HV128_RS02290 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HV128_RS02295 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV128_RS02300 ENOG4108IUZ ABC transporter HV128_RS02305 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HV128_RS02310 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HV128_RS02320 ENOG4105C2X Arabinose 5-phosphate isomerase HV128_RS02325 ENOG4105FEU K -dependent Na -Ca exchanger HV128_RS02330 ENOG4105DHJ ABC, transporter HV128_RS02335 ENOG4105CY3 ABC transporter, permease HV128_RS02340 ENOG4107PE3 Mammalian cell entry related domain protein HV128_RS02345 ENOG4105E3I toluene tolerance HV128_RS02350 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HV128_RS02355 ENOG4105VFK BolA family HV128_RS02360 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HV128_RS02365 ENOG4105HVQ Regulatory factor of maltose metabolism HV128_RS02370 ENOG4105EAH synthase HV128_RS02375 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HV128_RS02380 ENOG4105K46 50S ribosomal protein l27 HV128_RS02385 ENOG4105QYV Membrane HV128_RS02390 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HV128_RS02405 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HV128_RS02410 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HV128_RS02415 ENOG4105HBR Rna-binding protein HV128_RS02420 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HV128_RS02425 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HV128_RS02430 ENOG4105EEI dihydropteroate synthase HV128_RS02435 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HV128_RS02440 ENOG4105NTZ Preprotein translocase subunit SecG HV128_RS02450 ENOG4105CDH Citrulline--aspartate ligase HV128_RS02460 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HV128_RS02465 ENOG4105CHV Transcription elongation factor NusA HV128_RS02470 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HV128_RS02475 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HV128_RS02480 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HV128_RS02485 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HV128_RS02505 ENOG4105C1J atp-dependent rna helicase HV128_RS02510 ENOG4105CIC tryptophan-specific transport protein HV128_RS02515 ENOG4105DEN Luciferase family HV128_RS02535 ENOG4108YYD acetyltransferase HV128_RS02540 ENOG41082IR Excinuclease ABC C subunit domain protein HV128_RS02545 ENOG4108ZPB UPF0306 protein HV128_RS02550 ENOG4107R7Y intracellular protease Pfpi family HV128_RS02555 ENOG4105K4T epimerase HV128_RS02560 ENOG4107S21 permease HV128_RS02565 ENOG4105W4M Transport-associated protein HV128_RS02570 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HV128_RS02575 ENOG41082RQ UPF0102 protein HV128_RS02580 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HV128_RS02585 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HV128_RS02600 ENOG4105CI1 PTS System HV128_RS02605 ENOG4105D2N Aldolase HV128_RS02610 ENOG4105E70 isomerase HV128_RS02615 ENOG4105CE4 GlcNAc 6-P deacetylase HV128_RS02620 ENOG4105YHU PTS system HV128_RS02625 ENOG4105F3R pts system mannose fructose sorbose family iid HV128_RS02635 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HV128_RS02640 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HV128_RS02645 ENOG4105E98 transcriptional regulator DeoR family HV128_RS02650 ENOG4105CTX dehydratase HV128_RS02655 ENOG4105CNV Aldolase HV128_RS02660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV128_RS02665 ENOG4105BZW Glycerate kinase HV128_RS02675 ENOG410811B TRANSCRIPTIONal HV128_RS02680 ENOG4105C7B Threonine dehydratase HV128_RS02685 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HV128_RS02690 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV128_RS02695 ENOG4105C6N Formate acetyltransferase HV128_RS02700 ENOG4105C44 Serine transporter HV128_RS02710 ENOG4108CNN domain protein HV128_RS02715 ENOG4105CWB LysR family transcriptional Regulator HV128_RS02720 ENOG4105KAF membrAne HV128_RS02725 ENOG4105CHF Glutathione S-transferase HV128_RS02735 ENOG4105YJD HV128_RS02740 ENOG41090KG Inner membrane protein YqjE HV128_RS02745 ENOG4105NE1 Conserved Protein HV128_RS02750 ENOG4105WAY exported protein HV128_RS02755 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HV128_RS02760 ENOG4106W5V Membrane HV128_RS02765 ENOG4107YCY Transcriptional regulator HV128_RS02770 ENOG4105DPW Major facilitator superfamily MFS_1 HV128_RS02780 ENOG4105CTX dehydratase HV128_RS02790 ENOG4105DU1 integral membrane protein, terc HV128_RS02795 ENOG4105EE0 oxidoreductase HV128_RS02800 ENOG4108VKG metal-dependent hydrolase HV128_RS02805 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV128_RS02810 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV128_RS02815 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HV128_RS02820 ENOG4105DKT Transcriptional regulator HV128_RS02825 ENOG4105C2J ABC transporter HV128_RS02830 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HV128_RS02835 ENOG4105F5R ABC transporter HV128_RS02840 ENOG4105D4B ABC, transporter HV128_RS02845 ENOG41061GT Aldolase HV128_RS02850 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HV128_RS02865 ENOG4105C8Y Acetylornithine aminotransferase HV128_RS02870 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HV128_RS02875 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS02880 ENOG4105NTW Transcriptional regulator HV128_RS02885 ENOG4105Q26 Siderophore-interacting protein HV128_RS02915 ENOG4108VCA G U mismatch-specific DNA glycosylase HV128_RS02920 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV128_RS02925 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HV128_RS02940 ENOG4108S01 response regulator HV128_RS02950 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HV128_RS02955 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV128_RS02965 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HV128_RS02970 ENOG4105CQM Urea amidohydrolase subunit alpha HV128_RS02975 ENOG4105KI2 Urea amidohydrolase subunit beta HV128_RS02980 ENOG4108YZ9 Urea amidohydrolase subunit gamma HV128_RS02985 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV128_RS02990 ENOG4105C54 Major Facilitator superfamily HV128_RS03000 ENOG4107ZVW dihydroneopterin aldolase HV128_RS03010 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HV128_RS03015 ENOG4106MWK domain protein HV128_RS03020 ENOG4105I7R Adenylate cyclase HV128_RS03025 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HV128_RS03030 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HV128_RS03035 ENOG4105W0Z cytoplasmic protein HV128_RS03040 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HV128_RS03045 ENOG4108MY7 Fimbrial HV128_RS03050 ENOG4108TTM chaperone HV128_RS03055 ENOG4106PG1 outer membrane usher protein HV128_RS03060 ENOG4106UBK fimbrial-like adhesin protein HV128_RS03070 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HV128_RS03075 ENOG4106032 Glutathionylspermidine synthase HV128_RS03080 ENOG4105F1G UPF0441 protein HV128_RS03090 ENOG41087AY ADP-Ribose pyrophosphatase HV128_RS03095 ENOG4108SX3 cytoplasmic protein HV128_RS03100 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HV128_RS03105 ENOG4105IPS esterase HV128_RS03110 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV128_RS03125 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV128_RS03130 ENOG4105EP8 Glycosyl Hydrolase Family 88 HV128_RS03135 ENOG4109066 lysm domain bon superfamily protein HV128_RS03140 ENOG4105VRH Antibiotic biosynthesis monooxygenase HV128_RS03145 ENOG4105NF4 modulator of drug activity HV128_RS03150 ENOG4105DHQ Histidine kinase HV128_RS03155 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV128_RS03160 ENOG4105H4F exported protein HV128_RS03165 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV128_RS03170 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HV128_RS03175 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HV128_RS03215 ENOG4105F9F transposase HV128_RS03225 ENOG4105WAB arsR family transcriptional regulator HV128_RS03230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV128_RS03235 ENOG4105EQ2 LysR family Transcriptional regulator HV128_RS03240 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HV128_RS03245 ENOG4107RT3 EamA-like transporter family HV128_RS03270 ENOG4105E2A Dehydrogenase HV128_RS03315 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HV128_RS03355 ENOG4105CV8 reductase HV128_RS03360 ENOG4108I6A alcohol dehydrogenase HV128_RS03365 ENOG4105CF7 AraC family transcriptional regulator HV128_RS03370 ENOG4108K81 inner membrane protein YghB HV128_RS03375 ENOG4105C28 cystathionine HV128_RS03380 ENOG4105CWK Biopolymer transport protein, ExbB HV128_RS03385 ENOG4108ZZF transport protein (ExbD) HV128_RS03405 ENOG4108TEB UPF0114 protein HV128_RS03410 ENOG4105CPC Aldo Keto reductase HV128_RS03415 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS03420 ENOG4107EDW L-fucose operon activator HV128_RS03425 ENOG4105CYM Glutathione S-transferase HV128_RS03430 ENOG4106032 Glutathionylspermidine synthase HV128_RS03440 ENOG4105CND Glycosyl transferase, family 2 HV128_RS03445 ENOG4107BJW polysaccharide deacetylase HV128_RS03450 ENOG4108TUY outer membrane protein PgaA HV128_RS03470 ENOG4105WH1 Two component transcriptional regulator luxr family HV128_RS03475 ENOG4105BZU Histidine kinase HV128_RS03485 ENOG4108UQV Membrane HV128_RS03490 ENOG4105CXN decarboxylase HV128_RS03495 ENOG4106YYS transcriptional regulatory protein HV128_RS03500 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV128_RS03505 ENOG4105D2K citrate carrier protein HV128_RS03510 ENOG4105ERH Fumarylacetoacetate hydrolase HV128_RS03515 ENOG4105DUA (citrate (pro-3S)-lyase ligase HV128_RS03520 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HV128_RS03525 ENOG4105CI0 Citrate lyase HV128_RS03530 ENOG4105CHY citrate lyase, alpha HV128_RS03540 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HV128_RS03545 ENOG4105EAA nucleoside HV128_RS03550 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HV128_RS03555 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HV128_RS03560 ENOG4105CEN a g-specific adenine glycosylase HV128_RS03570 ENOG41090ED Protein with unknown function (DUF469) HV128_RS03575 ENOG4105K33 Periplasmic Protein HV128_RS03580 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HV128_RS03585 ENOG4105CSA Coproporphyrinogen iii oxidase HV128_RS03595 ENOG4105VZ9 UPF0235 protein HV128_RS03600 ENOG4108VIA integral membrane protein HV128_RS03605 ENOG4105DFA alanine racemase domain protein HV128_RS03610 ENOG4105CZX twitching motility protein HV128_RS03620 ENOG4108UJU UPF0301 protein HV128_RS03625 ENOG4105D7Z glutathione synthase HV128_RS03630 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HV128_RS03635 ENOG4105RWS endonuclease I HV128_RS03640 ENOG4105GPY SprT protein HV128_RS03645 ENOG4107QNK )-transporter HV128_RS03650 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HV128_RS03665 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HV128_RS03670 ENOG4105CYW agmatinase HV128_RS03695 ENOG4105CHR reductase HV128_RS03700 ENOG4108FUF Transcriptional regulator, IclR family HV128_RS03710 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HV128_RS03725 ENOG410832A alpha/beta hydrolase fold HV128_RS03730 ENOG4105CHR reductase HV128_RS03735 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) HV128_RS03750 ENOG4108K0D peptidase, M48 HV128_RS03755 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV128_RS03760 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV128_RS03765 ENOG4105CTS PTS system mannitol-specific HV128_RS03770 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HV128_RS03775 ENOG4108Q8A Fructose-1,6-bisphosphatase HV128_RS03780 ENOG4108R4K DNA-binding, transcriptional regulator HV128_RS03785 ENOG4107Z1W Fructose transport system kinase HV128_RS03790 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV128_RS03795 ENOG4105BZA Phosphoglycerate kinase HV128_RS03800 ENOG4105D2N Aldolase HV128_RS03805 ENOG4105D64 Mechanosensitive ion channel HV128_RS03810 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HV128_RS03815 ENOG4105MPN Membrane HV128_RS03820 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HV128_RS03825 ENOG4105E66 phosphoriboisomerase A HV128_RS03830 ENOG4108JQ1 Dehydrogenase HV128_RS03835 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HV128_RS03845 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HV128_RS03855 ENOG4107RAQ aminopeptidase HV128_RS03860 ENOG4105D0A hydroxylase HV128_RS03865 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV128_RS03870 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HV128_RS03880 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HV128_RS03885 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV128_RS03890 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV128_RS03910 ENOG4105CS2 ec 3.2.1.21 HV128_RS03915 ENOG4108Q3X Transcriptional regulator HV128_RS03920 ENOG4108UT2 hemolysin iii HV128_RS03925 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HV128_RS03930 ENOG4105Y75 tpr repeat protein HV128_RS03935 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HV128_RS03940 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HV128_RS03945 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV128_RS03950 ENOG4105T95 Thiol disulfide interChange protein HV128_RS03955 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HV128_RS03965 ENOG4105CRK lysyL-tRNA synthetase HV128_RS03970 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HV128_RS03975 ENOG4108K5P (LipO)protein HV128_RS04005 ENOG4105CHJ isochorismatase hydrolase HV128_RS04010 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HV128_RS04015 ENOG4108PNB DNA-binding transcriptional regulator HV128_RS04030 ENOG4105EUZ Beta-lactamase domain protein HV128_RS04035 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV128_RS04040 ENOG4108YDI single-species biofilm formation on inanimate substrate HV128_RS04055 ENOG4108WTK competence damage-inducible protein HV128_RS04065 ENOG4105CG3 alpha amylase, catalytic region HV128_RS04070 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV128_RS04075 ENOG4105C4M (Ubiquinol oxidase) subunit I HV128_RS04080 ENOG4105WEF catalase HV128_RS04085 ENOG4108N8X transition metal ion binding HV128_RS04090 ENOG4108Z9Z response to DNA damage stimulus HV128_RS04100 ENOG4105VR1 Pfam:DUF1271 HV128_RS04105 ENOG410830R acetyltransferase HV128_RS04110 ENOG4108MHD transport protein HV128_RS04125 ENOG4105CHU acetyl-coa acetyltransferase HV128_RS04130 ENOG4108QGT oligogalacturonate-specific porin HV128_RS04135 ENOG4105CAZ oligogalacturonide lyase HV128_RS04145 ENOG4105CHR reductase HV128_RS04150 ENOG4107QNK )-transporter HV128_RS04165 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HV128_RS04170 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HV128_RS04175 ENOG4108QY5 Ferric enterobactin transport protein HV128_RS04190 ENOG4105RQF LysR family Transcriptional regulator HV128_RS04200 ENOG4105DDV Transcriptional regulator (LacI family HV128_RS04205 ENOG4105CK1 PTS System HV128_RS04210 ENOG4105CS2 ec 3.2.1.21 HV128_RS04215 ENOG4105C6F GntR Family Transcriptional Regulator HV128_RS04225 ENOG41060NJ transcriptional regulator HV128_RS04230 ENOG4105CEY Amp-dependent synthetase and ligase HV128_RS04235 ENOG4107S74 Lysophospholipid transporter LplT HV128_RS04240 ENOG4105CPC Aldo Keto reductase HV128_RS04245 ENOG4105SUV lipoprotein YgdR HV128_RS04250 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HV128_RS04255 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HV128_RS04260 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HV128_RS04265 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HV128_RS04270 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HV128_RS04275 ENOG4105IPU prepilin peptidase dependent protein A HV128_RS04280 ENOG4105JCS prepilin peptidase dependent protein HV128_RS04285 ENOG4105SEN Protein of unknown function (DUF2509) HV128_RS04290 ENOG4105RVB Prepilin peptidase dependent protein c HV128_RS04295 ENOG4105DSY exodeoxyribonuclease V, gamma HV128_RS04300 ENOG4107QXK peptidase HV128_RS04305 ENOG4107QKA exodeoxyribonuclease V beta HV128_RS04310 ENOG4107QYX exodeoxyribonuclease v alpha HV128_RS04315 ENOG4107QZM n-acetylglutamate synthase HV128_RS04320 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV128_RS04340 ENOG4105CA3 membrane-bound lytic murein transglycosylase HV128_RS04345 ENOG4105CUZ uba thif-type nad fad binding protein HV128_RS04350 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV128_RS04355 ENOG4105C9B Cysteine desulfurase HV128_RS04360 ENOG4105M5B (LipO)protein HV128_RS04365 ENOG4105ETT transcriptional Regulator, LysR family HV128_RS04370 ENOG4105M08 Membrane HV128_RS04375 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HV128_RS04380 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HV128_RS04385 ENOG4105EJQ L-serine dehydratase HV128_RS04390 ENOG4105C44 Serine transporter HV128_RS04395 ENOG4105EWT decarboxylase family HV128_RS04405 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HV128_RS04410 ENOG4105WP7 tRNA pseudouridine synthase C HV128_RS04415 ENOG4105DR9 pseudouridine synthase HV128_RS04420 ENOG4105QDK Flavodoxin HV128_RS04425 ENOG4105DJB Major Facilitator Superfamily HV128_RS04430 ENOG4105EQX glucarate dehydratase HV128_RS04435 ENOG4105EQX glucarate dehydratase HV128_RS04440 ENOG4105BZW Glycerate kinase HV128_RS04445 ENOG4105BZU Histidine kinase HV128_RS04450 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HV128_RS04455 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV128_RS04460 ENOG4105DXN mazG family HV128_RS04465 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HV128_RS04470 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HV128_RS04475 ENOG4105QEK Transcriptional regulator HV128_RS04480 ENOG4105CI1 PTS System HV128_RS04485 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HV128_RS04490 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HV128_RS04500 ENOG4105CH2 amidohydrolase HV128_RS04505 ENOG41063ZK Transcriptional Regulator AraC Family HV128_RS04510 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HV128_RS04515 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HV128_RS04525 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HV128_RS04530 ENOG4108MXK alkaline phosphatase isozyme conversion HV128_RS04535 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HV128_RS04540 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HV128_RS04550 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) HV128_RS04555 ENOG4105N0Z inner membrane protein ygbE HV128_RS04560 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV128_RS04565 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HV128_RS04570 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HV128_RS04575 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HV128_RS04580 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HV128_RS04585 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HV128_RS04590 ENOG4108K5P (LipO)protein HV128_RS04605 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV128_RS04610 ENOG4105JQN Transcriptional regulator HV128_RS04620 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV128_RS04625 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV128_RS04630 ENOG4105KZM cytoplasmic protein HV128_RS04635 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HV128_RS04640 ENOG41067CV Integrase HV128_RS04705 ENOG4105DZR Type I site-specific deoxyribonuclease HV128_RS04715 ENOG4105CVR type I restriction-modification system HV128_RS04760 ENOG4105VXR cytoplasmic protein HV128_RS04770 ENOG4105E0A ABC, transporter HV128_RS04775 ENOG4105EHG Permease protein HV128_RS04790 ENOG4105C45 hydrogenase expression formation protein (HypE) HV128_RS04795 ENOG4105CQS hydrogenase expression formation protein HypD HV128_RS04800 ENOG41083WG hydrogenase assembly chaperone HV128_RS04805 ENOG4107RSS Hydrogenase accessory protein HypB HV128_RS04810 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HV128_RS04815 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HV128_RS04820 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV128_RS04825 ENOG4107R30 NADH dehydrogenase HV128_RS04830 ENOG4107TDF Formate hydrogenlyase subunit 4 HV128_RS04835 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV128_RS04840 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HV128_RS04845 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HV128_RS04850 ENOG4105I6X formate hydrogenlyase maturation HV128_RS04855 ENOG4108MG9 hydrogenase 3 maturation protease HV128_RS04860 ENOG4105CS2 ec 3.2.1.21 HV128_RS04865 ENOG4105C5Y PTS System HV128_RS04870 ENOG4105DDV Transcriptional regulator (LacI family HV128_RS04875 ENOG4108RC0 Electron transport protein HV128_RS04880 ENOG4105C8H hydrogenase maturation protein Hypf HV128_RS04890 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HV128_RS04895 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center HV128_RS04900 ENOG4108JUA Transcriptional regulator HV128_RS04910 ENOG410804X Transcriptional regulator HV128_RS04915 ENOG4105J92 DNA-binding transcriptional activator GutM HV128_RS04920 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HV128_RS04925 ENOG4105VI0 Pts system, glucitol sorbitol-specific HV128_RS04930 ENOG4105DZY Pts system, glucitol sorbitol-specific HV128_RS04935 ENOG410787A Pts system, glucitol sorbitol-specific HV128_RS04940 ENOG4105CVE Lytic murein transglycosylase HV128_RS04945 ENOG4105DIK (ABC) transporter HV128_RS04950 ENOG4105CC5 ABC transporter HV128_RS04960 ENOG4107TH8 cina domain protein HV128_RS04965 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HV128_RS04975 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HV128_RS04980 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HV128_RS05010 ENOG4107VXZ Hydrolase HV128_RS05015 ENOG4105W39 Membrane HV128_RS05020 ENOG4105D9M gamma-glutamylcysteine synthetase HV128_RS05025 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HV128_RS05035 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HV128_RS05040 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV128_RS05045 ENOG4105CW7 secretion protein, HlyD family HV128_RS05050 ENOG4105NTK Transcriptional repressor Mpra HV128_RS05060 ENOG4105GIJ Glycine betaine HV128_RS05065 ENOG4108HQS Glycine betaine HV128_RS05070 ENOG4108IJ7 Glycine betaine HV128_RS05075 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV128_RS05080 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV128_RS05085 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HV128_RS05090 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HV128_RS05095 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HV128_RS05100 ENOG4108WMJ Protein of unknown function (DUF2002) HV128_RS05105 ENOG4108RNS Exports L-alanine (By similarity) HV128_RS05110 ENOG4108X73 DNA- binding protein HV128_RS05120 ENOG4108V62 Rhodanese domain protein HV128_RS05125 ENOG4105VPI YqaE family transport protein HV128_RS05130 ENOG4108NUU Transcriptional regulator HV128_RS05135 ENOG4107SNB ankyrin repeat protein YahD HV128_RS05140 ENOG4107R1Q Membrane protein FdrA HV128_RS05145 ENOG4107REC cytoplasmic protein HV128_RS05155 ENOG4105C5B carbamate kinase HV128_RS05160 ENOG4105DZC cytosine deaminase HV128_RS05175 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV128_RS05200 ENOG4105EQ2 LysR family Transcriptional regulator HV128_RS05205 ENOG4105EMU Dehydrogenase HV128_RS05220 ENOG4105BZU Histidine kinase HV128_RS05250 ENOG4105EQR Transposase IS116 IS110 IS902 HV128_RS05285 ENOG4105CNV Aldolase HV128_RS05290 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV128_RS05295 ENOG4108R85 Short chain dehydrogenase HV128_RS05310 ENOG4105ETE Transcriptional regulator (LacI family HV128_RS05350 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HV128_RS05360 ENOG4108RVA ribokinase HV128_RS05405 ENOG4105ZTC transcriptional activator, Ogr delta HV128_RS05420 ENOG4105DFP Integrase HV128_RS05435 ENOG4108Z1B Cyclase dehydrase HV128_RS05440 ENOG4105VDB UPF0125 protein HV128_RS05445 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV128_RS05450 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HV128_RS05455 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HV128_RS05465 ENOG4108JU6 CBS domain protein HV128_RS05470 ENOG4106KVJ cytochrome C assembly protein HV128_RS05475 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HV128_RS05480 ENOG4105K5M 30s ribosomal protein S16 HV128_RS05485 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HV128_RS05490 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HV128_RS05495 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HV128_RS05510 ENOG41090EK ompa motb domain protein HV128_RS05515 ENOG4108KHX Diguanylate cyclase HV128_RS05520 ENOG4108WS1 HV128_RS05525 ENOG4105QP9 Protein of unknown function (DUF2799) HV128_RS05530 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV128_RS05535 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HV128_RS05545 ENOG4105CQC Prephenate dehydratase HV128_RS05555 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HV128_RS05560 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV128_RS05565 ENOG4105C34 Pseudouridine synthase HV128_RS05570 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HV128_RS05575 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV128_RS05605 ENOG4105CSH Transporter HV128_RS05610 ENOG4105T42 (LipO)protein HV128_RS05615 ENOG4105JIM Phosphatidylserine synthase HV128_RS05620 ENOG4105CD5 CoA-binding domain protein HV128_RS05625 ENOG4106IUH DTW domain containing protein HV128_RS05630 ENOG4105K63 Thioredoxin HV128_RS05635 ENOG4105EIB trna rrna methyltransferase HV128_RS05640 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HV128_RS05645 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HV128_RS05650 ENOG4105C1J atp-dependent rna helicase HV128_RS05655 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HV128_RS05660 ENOG4108IYU L-aspartate oxidase HV128_RS05670 ENOG41069PW sigma-e factor negative regulatory protein HV128_RS05680 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HV128_RS05825 ENOG4105CDU Replicative dna helicase HV128_RS05855 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HV128_RS05860 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HV128_RS05865 ENOG4108R1E Serine threonine protein phosphatase 1 HV128_RS05875 ENOG4105QBX endodeoxyribonuclease RusA HV128_RS05900 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HV128_RS05925 ENOG4108N0N Phage Terminase Large Subunit HV128_RS06120 ENOG4105C3F Signal peptidase i HV128_RS06125 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HV128_RS06135 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HV128_RS06140 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HV128_RS06145 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HV128_RS06150 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HV128_RS06155 ENOG4106G6Q Transcriptional regulator HV128_RS06160 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HV128_RS06170 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HV128_RS06175 ENOG4108Z6B deaminase HV128_RS06180 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HV128_RS06185 ENOG4107QIK phosphoribosylformylglycinamidine synthase HV128_RS06190 ENOG4107WP9 Histidine kinase HV128_RS06195 ENOG4108SKK alpha helix protein HV128_RS06200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV128_RS06205 ENOG4108YZA Nitrogen regulatory protein pii HV128_RS06210 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV128_RS06215 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HV128_RS06220 ENOG4108SB3 DoxX Family HV128_RS06225 ENOG4105D8G Major Facilitator superfamily HV128_RS06230 ENOG4108MN2 Stationary phase inducible protein CsiE HV128_RS06240 ENOG4105D7X high-affinity nickel-transporter HV128_RS06245 ENOG4105ECY inositol monophosphatase HV128_RS06250 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HV128_RS06255 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV128_RS06260 ENOG4105C3J Cysteine desulfurase HV128_RS06265 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HV128_RS06270 ENOG4108Z4V iron-sulfur cluster assembly HV128_RS06275 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HV128_RS06280 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HV128_RS06285 ENOG4108ZIT Ferredoxin, 2FE-2S HV128_RS06290 ENOG4105WVQ Fe-S assembly protein IscX HV128_RS06295 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV128_RS06300 ENOG4105YYA enhanced serine sensitivity protein SseB HV128_RS06305 ENOG4108Q3X Transcriptional regulator HV128_RS06310 ENOG4105KHC sulfurtransferase HV128_RS06320 ENOG4105CI1 PTS System HV128_RS06325 ENOG4105DN3 alpha-2-macroglobulin domain protein HV128_RS06330 ENOG4108JQB penicillin-binding protein 1C HV128_RS06335 ENOG4107QY8 reductase HV128_RS06340 ENOG4105QAX Iron-sulfur HV128_RS06350 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV128_RS06355 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HV128_RS06360 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HV128_RS06370 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HV128_RS06375 ENOG4105CUT histidyl-tRNA synthetase HV128_RS06380 ENOG4105N21 Membrane HV128_RS06385 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV128_RS06390 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HV128_RS06395 ENOG4105DUX Transporter HV128_RS06400 ENOG4105VPD cellular component movement HV128_RS06410 ENOG4105D4Y metalloprotease HV128_RS06415 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HV128_RS06420 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV128_RS06430 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HV128_RS06435 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV128_RS06455 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV128_RS06460 ENOG4105Z4Q MltA-interacting MipA family protein HV128_RS06470 ENOG41062G3 Protein of unknown function (DUF2633) HV128_RS06475 ENOG4105BZU Histidine kinase HV128_RS06480 ENOG4105C9X ppx gppa phosphatase HV128_RS06490 ENOG4108V3E phosphoribosylglycinamide formyltransferase HV128_RS06500 ENOG4105CS2 ec 3.2.1.21 HV128_RS06505 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HV128_RS06510 ENOG4105C2W permease HV128_RS06515 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HV128_RS06520 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV128_RS06540 ENOG4105K89 arsenate reductase HV128_RS06545 ENOG4105ERG peptidase m48, ste24p HV128_RS06550 ENOG4105C02 permease HV128_RS06555 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV128_RS06560 ENOG4105RH4 Glycine cleavage system transcriptional repressor HV128_RS06570 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV128_RS06575 ENOG4105C8V SAICAR synthetase HV128_RS06580 ENOG4105CGZ zinc metallopeptidase HV128_RS06585 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HV128_RS06590 ENOG4106KED esterase YpfH HV128_RS06600 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HV128_RS06605 ENOG4105KUZ arsenate reductase HV128_RS06615 ENOG4105BZS acriflavin resistance protein HV128_RS06620 ENOG4105BZU Histidine kinase HV128_RS06625 ENOG4105BZ8 glutamate synthase HV128_RS06630 ENOG4107VIJ nudix hydrolase HV128_RS06635 ENOG4108PVD exported protein HV128_RS06640 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV128_RS06650 ENOG4105C6K Malic enzyme HV128_RS06655 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HV128_RS06660 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HV128_RS06665 ENOG4108R6G acetyltransferase HV128_RS06670 ENOG4105QZU Inner membrane protein YfeZ HV128_RS06675 ENOG4105E7K (LipO)protein HV128_RS06680 ENOG4105EZR dyp-type peroxidase family protein HV128_RS06685 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HV128_RS06690 ENOG4108I5D sulfate abc transporter HV128_RS06695 ENOG4105ECW sulfate abc transporter HV128_RS06700 ENOG4108IJ6 ABC transporter HV128_RS06705 ENOG4105C6T cysteine synthase HV128_RS06715 ENOG4105C5Y PTS System HV128_RS06720 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV128_RS06730 ENOG4105C6T cysteine synthase HV128_RS06735 ENOG4105EXN Sulfate transport protein CysZ HV128_RS06740 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HV128_RS06745 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HV128_RS06750 ENOG4105VRT cytoplasmic protein HV128_RS06755 ENOG4105DHU Bile acid HV128_RS06760 ENOG4108M0I Transcriptional regulator HV128_RS06790 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HV128_RS06795 ENOG4105GXM Putative transcription regulator (DUF1323) HV128_RS06800 ENOG4105HZG regulatoR HV128_RS06815 ENOG4108KMM Diguanylate cyclase HV128_RS06820 ENOG4105D9N nucleoside HV128_RS06825 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HV128_RS06835 ENOG4105CPC Aldo Keto reductase HV128_RS06840 ENOG4107RA9 decarboxylase HV128_RS06850 ENOG4105CHC glucokinase (EC 2.7.1.2) HV128_RS06855 ENOG4105DY9 regulatoR HV128_RS06860 ENOG4108HRK Histidine kinase HV128_RS06865 ENOG4105EQR Transposase IS116 IS110 IS902 HV128_RS06870 ENOG4105CHM Aminotransferase HV128_RS06880 ENOG4105D1S lipid A biosynthesis HV128_RS06885 ENOG4105BZU Histidine kinase HV128_RS06890 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HV128_RS06895 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV128_RS06900 ENOG4105ZS6 Protein of unknown function (DUF987) HV128_RS06905 ENOG4108XS9 dna repair protein HV128_RS06910 ENOG4106549 Antirestriction protein HV128_RS06915 ENOG4106ZN7 UPF0401 protein YkfF HV128_RS06920 ENOG4106H6R UPF0380 protein HV128_RS06935 ENOG4108KZE transcriptional regulator HV128_RS06940 ENOG4108MXD gtp-binding protein HV128_RS06980 ENOG4105F9F transposase HV128_RS06990 ENOG4105EKQ RNA-directed DNA polymerase HV128_RS07025 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV128_RS07035 ENOG4105ETE Transcriptional regulator (LacI family HV128_RS07045 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HV128_RS07055 ENOG4108XS9 dna repair protein HV128_RS07060 ENOG4105MFG Antirestriction protein HV128_RS07065 ENOG4106ZN7 UPF0401 protein YkfF HV128_RS07070 ENOG4106J9S Prophage HV128_RS07090 ENOG4106H6R UPF0380 protein HV128_RS07095 ENOG4105TS0 gtp-binding protein HV128_RS07130 ENOG4105NI8 Cytosine-specific methyltransferase HV128_RS07185 ENOG4105S64 Formate nitrite transporter HV128_RS07190 ENOG410903C (LipO)protein HV128_RS07195 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HV128_RS07200 ENOG4105KZW UPF0381 protein HV128_RS07205 ENOG4105CHU acetyl-coa acetyltransferase HV128_RS07210 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV128_RS07215 ENOG4108BY2 phosphohistidine phosphatase HV128_RS07220 ENOG4108DG9 Smr protein MutS2 HV128_RS07225 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HV128_RS07230 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HV128_RS07235 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HV128_RS07240 ENOG4105EJ9 Membrane HV128_RS07245 ENOG4108BPE -transporting atpase HV128_RS07250 ENOG4105MH2 YfcL protein HV128_RS07255 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HV128_RS07260 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV128_RS07265 ENOG4105F9N Major Facilitator Superfamily HV128_RS07270 ENOG4106WZ1 flagella biosynthesis regulator HV128_RS07275 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HV128_RS07280 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV128_RS07285 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HV128_RS07290 ENOG4105DQR SNARE associated Golgi HV128_RS07295 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HV128_RS07300 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HV128_RS07305 ENOG4108S3P Sporulation domain protein HV128_RS07310 ENOG4105E96 Colicin v production protein HV128_RS07315 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HV128_RS07320 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV128_RS07325 ENOG4105E89 ABC transporter HV128_RS07330 ENOG4105E89 ABC transporter HV128_RS07335 ENOG4105DSP amino acid AbC transporter HV128_RS07340 ENOG4106YG3 ABC transporter HV128_RS07345 ENOG4108JEH abc transporter atp-binding protein HV128_RS07350 ENOG4105D9U N-acetyltransferase HV128_RS07355 ENOG4105ECP epimerase HV128_RS07360 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HV128_RS07365 ENOG4105CYM Glutathione S-transferase HV128_RS07370 ENOG4108SHQ Glutathione S-transferase HV128_RS07375 ENOG4108RE9 Phosphodiesterase HV128_RS07380 ENOG4105PTV Nudix Hydrolase HV128_RS07385 ENOG4105K2J Transcriptional regulator HV128_RS07390 ENOG4106ETB IIa component HV128_RS07400 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HV128_RS07405 ENOG4108HHA Transketolase HV128_RS07410 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HV128_RS07415 ENOG4105C6K Malic enzyme HV128_RS07420 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV128_RS07430 ENOG4105XWI UPF0304 protein HV128_RS07435 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HV128_RS07440 ENOG4107QWE )-transporter HV128_RS07445 ENOG4105DK2 UPF0207 protein HV128_RS07450 ENOG4105CHM Aminotransferase HV128_RS07455 ENOG4107NQ8 LysR family Transcriptional regulator HV128_RS07460 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HV128_RS07465 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV128_RS07470 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV128_RS07475 ENOG4105GKE subunit e HV128_RS07480 ENOG4107QIZ NADH dehydrogenase HV128_RS07485 ENOG4108IEH NADH dehydrogenase subunit g HV128_RS07490 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HV128_RS07500 ENOG4107UFS subunit j HV128_RS07505 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV128_RS07510 ENOG4105D65 subunit l HV128_RS07515 ENOG4105C8S subunit m HV128_RS07520 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV128_RS07530 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HV128_RS07535 ENOG4107YB6 acetyltransferase, (GNAT) family HV128_RS07540 ENOG4105TNS Conserved Protein HV128_RS07545 ENOG4105E4F Isochorismate synthase HV128_RS07550 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HV128_RS07555 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HV128_RS07560 ENOG4108IPT Naphthoate synthase HV128_RS07565 ENOG4105DNI Converts SHCHC to OSB (By similarity) HV128_RS07570 ENOG4105CEY Amp-dependent synthetase and ligase HV128_RS07595 ENOG4105DHQ Histidine kinase HV128_RS07600 ENOG4108UII YfaZ family HV128_RS07605 ENOG4108EWA cinA-like protein HV128_RS07610 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV128_RS07615 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HV128_RS07620 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HV128_RS07625 ENOG4105CXY transporter HV128_RS07630 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HV128_RS07635 ENOG4105XPH Ferredoxin HV128_RS07640 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV128_RS07645 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV128_RS07650 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HV128_RS07655 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV128_RS07660 ENOG4105BZU Histidine kinase HV128_RS07665 ENOG41068CG regulatoR HV128_RS07670 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HV128_RS07685 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV128_RS07690 ENOG4105CF1 Alkylated DNA repair protein HV128_RS07695 ENOG4105IBP Cyclic peptide transporter HV128_RS07700 ENOG4105CJW magnesium transporter HV128_RS07705 ENOG4105CHH sulfate transporter HV128_RS07710 ENOG4105DWT malate dehydrogenase (quinone) HV128_RS07720 ENOG4105S5I Membrane HV128_RS07730 ENOG4105E68 Sulfatase HV128_RS07735 ENOG4105PAN UPF0352 protein HV128_RS07740 ENOG4106V8H Nucleoid-associated protein HV128_RS07745 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HV128_RS07750 ENOG4105CFI type iii restriction protein res subunit HV128_RS07755 ENOG4105I08 Pseudouridine synthase HV128_RS07760 ENOG4105C2C drug resistance transporter, Bcr CflA HV128_RS07765 ENOG4105HG6 HV128_RS07770 ENOG4108JQ5 ABC transporter HV128_RS07775 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HV128_RS07780 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HV128_RS07785 ENOG4105E43 Extracellular solute-binding protein, family 5 HV128_RS07790 ENOG4105CXC rtn protein HV128_RS07795 ENOG4107TT5 NLP P60 protein HV128_RS07800 ENOG41076MN Phosphoesterase, PA-phosphatase related HV128_RS07805 ENOG4105CKI cobalamin synthesis protein HV128_RS07810 ENOG4105DEI Mannitol dehydrogenase HV128_RS07815 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HV128_RS07820 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HV128_RS07825 ENOG4105KRS Proteinase inhibitor HV128_RS07830 ENOG4105S8Q sugar efflux transporter HV128_RS07835 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV128_RS07840 ENOG4105DE4 1-phosphofructokinase HV128_RS07845 ENOG4105DM4 PTS System HV128_RS07850 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HV128_RS07855 ENOG4105HMI Membrane HV128_RS07860 ENOG4105DUM transcriptional regulator, lysR family HV128_RS07865 ENOG4108IQI permease HV128_RS07870 ENOG4105D05 Receptor HV128_RS07875 ENOG4105C4W S-formylglutathione hydrolase HV128_RS07880 ENOG4105CBP Major Facilitator HV128_RS07885 ENOG4105EUJ GTP cyclohydrolase i HV128_RS07890 ENOG4105DHF Membrane HV128_RS07895 ENOG41060NJ transcriptional regulator HV128_RS07905 ENOG4105C2J ABC transporter HV128_RS07910 ENOG4107SDZ Galactoside transport system permease protein mglC HV128_RS07925 ENOG4107GZ4 SanA protein HV128_RS07930 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HV128_RS07935 ENOG41067MG lrgb family HV128_RS07940 ENOG4105VAW lrga family HV128_RS07945 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HV128_RS07950 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV128_RS07955 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HV128_RS07960 ENOG4105KHU inner membrane protein YohD HV128_RS07965 ENOG41069YE inner membrane protein yohC HV128_RS07970 ENOG41061WM D-Alanyl-D-Alanine HV128_RS07980 ENOG4105CXG d-lactate dehydrogenase HV128_RS07985 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HV128_RS07990 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV128_RS07995 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HV128_RS08000 ENOG4108IJ8 ABC transporter HV128_RS08005 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HV128_RS08015 ENOG4108XDN Transcriptional regulator HV128_RS08020 ENOG4108HRK Histidine kinase HV128_RS08025 ENOG4108NEV two component transcriptional regulator, LytTR family HV128_RS08030 ENOG4108W15 Protein of unknown function (DUF1456) HV128_RS08040 ENOG4105D1F ATP-binding protein HV128_RS08050 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HV128_RS08055 ENOG4105DAY polysaccharide export protein HV128_RS08060 ENOG4107ZF2 Phosphatase HV128_RS08065 ENOG4108F2G Chain length determinant protein HV128_RS08070 ENOG4105DY8 decarboxylase HV128_RS08075 ENOG4108JPW Aminotransferase HV128_RS08090 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HV128_RS08095 ENOG4105DWF phosphomethylpyrimidine kinase HV128_RS08100 ENOG4105FDP GntR family transcriptional regulator HV128_RS08105 ENOG4108TFM Kinase, PfkB family HV128_RS08110 ENOG4108KD5 ADP-ribosylation crystallin J1 HV128_RS08115 ENOG4105EAA nucleoside HV128_RS08120 ENOG4105EIE fructose-bisphosphate aldolase HV128_RS08125 ENOG4107TE5 Lipid kinase HV128_RS08130 ENOG4105CFP Peptidase U32 HV128_RS08140 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV128_RS08145 ENOG4105EB3 Histidine kinase HV128_RS08150 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV128_RS08155 ENOG4105BZS acriflavin resistance protein HV128_RS08160 ENOG4105BZS acriflavin resistance protein HV128_RS08165 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV128_RS08170 ENOG4105R8A Heat shock protein HV128_RS08175 ENOG4105D03 DNA-3-methyladenine glycosylase II HV128_RS08180 ENOG4105BZU Histidine kinase HV128_RS08190 ENOG4105DHP deoxycytidine triphosphate deaminase HV128_RS08195 ENOG4108GAE asmA family HV128_RS08200 ENOG4105EE5 Membrane protein terC HV128_RS08205 ENOG4105DAY polysaccharide export protein HV128_RS08210 ENOG4105KJF protein tyrosine phosphatase HV128_RS08215 ENOG4105D75 Capsular exopolysaccharide family HV128_RS08220 ENOG41090RK glycosyl transferase HV128_RS08225 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HV128_RS08230 ENOG4107RXY Glycosyl transferase HV128_RS08235 ENOG4108NYJ Colanic acid HV128_RS08240 ENOG4105ECJ Glycosyl Transferase HV128_RS08245 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HV128_RS08250 ENOG4105C0K Gdp-mannose 4,6-dehydratase HV128_RS08255 ENOG4105C30 Nad-dependent epimerase dehydratase HV128_RS08260 ENOG4105FGF GDP-mannose mannosyl hydrolase HV128_RS08265 ENOG4106CD9 glycosyl transferase group 1 HV128_RS08270 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HV128_RS08275 ENOG4107QKV phosphomannomutase HV128_RS08280 ENOG4105D3Q Sugar transferase HV128_RS08285 ENOG4105PSV Polysaccharide Biosynthesis Protein HV128_RS08290 ENOG4105C74 pyruvyl transferase HV128_RS08295 ENOG4107T8Q Glycosyl transferase (Group 1 HV128_RS08300 ENOG4105G1A colanic acid biosynthesis protein HV128_RS08305 ENOG4105DMT epimerase dehydratase HV128_RS08310 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV128_RS08315 ENOG4107XU6 Glycosyl transferase (Group 1 HV128_RS08325 ENOG4105K64 Glycosyl transferase, family 2 HV128_RS08340 ENOG4105CPK Glycosyl transferase (Group 1 HV128_RS08350 ENOG4105CMR udp-glucose 4-epimerase HV128_RS08355 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HV128_RS08360 ENOG4105C1B dTDP-glucose 4-6-dehydratase HV128_RS08365 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HV128_RS08380 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HV128_RS08390 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HV128_RS08395 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HV128_RS08400 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HV128_RS08405 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HV128_RS08410 ENOG4105CIH Imidazole acetol-phosphate transaminase HV128_RS08420 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HV128_RS08430 ENOG4107SRH Nad-dependent epimerase dehydratase HV128_RS08435 ENOG4105EQ1 Transcriptional regulator HV128_RS08445 ENOG4105CUB amino acid HV128_RS08450 ENOG4105CJB Exodeoxyribonuclease I HV128_RS08455 ENOG4105DZ1 carboxypeptidase HV128_RS08460 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HV128_RS08465 ENOG4105DR8 Membrane HV128_RS08480 ENOG4105UQX Mate efflux family protein HV128_RS08490 ENOG4105FYV Amp nucleosidase HV128_RS08495 ENOG4105CSH Transporter HV128_RS08510 ENOG4105BZS acriflavin resistance protein HV128_RS08520 ENOG4108U51 Universal stress protein HV128_RS08530 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV128_RS08545 ENOG4107R11 Transcriptional regulator HV128_RS08550 ENOG4105XUP Phage derived protein Gp49-like (DUF891) HV128_RS08570 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HV128_RS08575 ENOG4105DUU IucA IucC family protein HV128_RS08600 ENOG4105F04 LysR family Transcriptional regulator HV128_RS08610 ENOG4105CSH Transporter HV128_RS08625 ENOG4107GFK fumarate HV128_RS08645 ENOG4108MRH transcriptional regulatory protein HV128_RS08650 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV128_RS08655 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HV128_RS08660 ENOG4105FCK Membrane HV128_RS08665 ENOG4105EST Metal Dependent Phosphohydrolase HV128_RS08670 ENOG4105DVF Cytosine-specific methyltransferase HV128_RS08675 ENOG41090BB DNA mismatch endonuclease (vsr) HV128_RS08680 ENOG4105FDR Membrane HV128_RS08685 ENOG4105CKW Inner membrane protein yedI HV128_RS08690 ENOG4105VNZ cytoplasmic protein HV128_RS08700 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase HV128_RS08705 ENOG4105YX3 cellular response to acidity HV128_RS08715 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HV128_RS08720 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HV128_RS08730 ENOG4105CN7 Flagellar biosynthetic protein FliP HV128_RS08735 ENOG4105K0P flagellar biosynthesis protein HV128_RS08740 ENOG4105DD5 Flagellar motor switch protein HV128_RS08745 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV128_RS08750 ENOG4107ZI8 flagellar basal body-associated protein flil HV128_RS08755 ENOG4105WF4 Flagellar hook-length control protein HV128_RS08760 ENOG4105GSA Flagellar export protein flij HV128_RS08765 ENOG4108JIR Flagellum-specific ATP synthase HV128_RS08770 ENOG41090PJ Flagellar assembly protein HV128_RS08775 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV128_RS08780 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HV128_RS08785 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HV128_RS08790 ENOG4108W9D (LipO)protein HV128_RS08795 ENOG4105E5K Alpha-amylase HV128_RS08805 ENOG4105MQ3 flagellar protein FliS HV128_RS08810 ENOG4105DTS flagellar hook-associated HV128_RS08815 ENOG4105I03 Flagellin HV128_RS08820 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV128_RS08825 ENOG4108M9K flagella biosynthesis protein FliZ HV128_RS08830 ENOG4105EAB amino acid AbC transporter HV128_RS08835 ENOG4105K6H D-cysteine desulfhydrase HV128_RS08840 ENOG4105E5Q amino acid AbC transporter HV128_RS08845 ENOG4105CDA abc transporter atp-binding protein HV128_RS08850 ENOG4105VJY transcriptional regulator HV128_RS08855 ENOG4105XVG cytoplasmic protein HV128_RS08860 ENOG4105WH1 Two component transcriptional regulator luxr family HV128_RS08865 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HV128_RS08890 ENOG4105DQS Transcriptional regulator HV128_RS08900 ENOG4108IV0 ABC, transporter HV128_RS08905 ENOG4105C0Z ABC transporter HV128_RS08910 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV128_RS08915 ENOG4105C32 Amino acid ABC transporter (Permease) HV128_RS08925 ENOG4106RHG Yeca family HV128_RS08930 ENOG4105E0U tyrosine-specific transport protein HV128_RS08935 ENOG4105VVZ metal-binding protein HV128_RS08940 ENOG41090A1 ferritin HV128_RS08965 ENOG4105N4N Protein of unknown function (DUF2766) HV128_RS08970 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV128_RS08975 ENOG4108UEC Ferritin-like protein HV128_RS08985 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HV128_RS08995 ENOG4105CNN ABC, transporter HV128_RS09000 ENOG4108K4C ec 3.1.3.12 HV128_RS09005 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HV128_RS09010 ENOG4108VA4 Universal stress protein HV128_RS09015 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HV128_RS09020 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HV128_RS09025 ENOG4107RD7 Flagellar Motor Protein, MotA HV128_RS09030 ENOG4105ER2 Ompa motb domain protein HV128_RS09035 ENOG4105CBS Chea signal transduction histidine kinase HV128_RS09040 ENOG4108V3W Chemotaxis protein, CheW HV128_RS09045 ENOG4107QJT sodium dicarboxylate symporter HV128_RS09075 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS09080 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS09085 ENOG4105BZU Histidine kinase HV128_RS09095 ENOG4108VYJ response regulator receiver protein HV128_RS09100 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HV128_RS09125 ENOG4105D00 flagellar biosynthetic protein flhB HV128_RS09130 ENOG4105D7B Flagellar biosynthesis protein flha HV128_RS09135 ENOG4105W13 flagellar protein HV128_RS09145 ENOG4105F5H Glycosyl Hydrolase Family 88 HV128_RS09150 ENOG4105C75 arginyL-tRNA synthetase HV128_RS09155 ENOG4106ZCM YecM protein HV128_RS09160 ENOG4106N3A copper homeostasis protein cutc HV128_RS09165 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HV128_RS09170 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HV128_RS09175 ENOG4105WJG Glutathione HV128_RS09180 ENOG41081XQ Conserved Protein HV128_RS09185 ENOG4107R08 Integrase HV128_RS09235 ENOG4105W7J DNA binding HV128_RS09245 ENOG4105CAR Terminase, large subunit HV128_RS09255 ENOG4105HGD Antitermination protein HV128_RS09275 ENOG4105NVB glycoside hydrolase, family 19 HV128_RS09320 ENOG4105CAR Terminase, large subunit HV128_RS09330 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HV128_RS09440 ENOG4108C33 Resolvase HV128_RS09450 ENOG4105Y50 Virulence Protein HV128_RS09455 ENOG4105D3W isochorismatase HV128_RS09460 ENOG4105C9M aspartyl-trna synthetase HV128_RS09465 ENOG4108TIT dATP pyrophosphohydrolase HV128_RS09470 ENOG4105CDY transcriptional regulatory protein HV128_RS09475 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HV128_RS09480 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HV128_RS09485 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HV128_RS09490 ENOG4105FAV ABC, transporter HV128_RS09500 ENOG4105NXV High-affinity zinc uptake system protein HV128_RS09505 ENOG4105DR5 peptidase HV128_RS09510 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HV128_RS09515 ENOG4105CA9 Pyruvate kinase HV128_RS09520 ENOG4106KNT transcriptional regulator HV128_RS09525 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HV128_RS09530 ENOG4105C01 Dihydroxy-acid dehydratase HV128_RS09535 ENOG4108UHU Aldolase HV128_RS09540 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HV128_RS09545 ENOG4108Q2J Inner membrane protein YebE HV128_RS09550 ENOG4105CUG Oligopeptidase b HV128_RS09555 ENOG4105UMD exodeoxyribonuclease X HV128_RS09560 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV128_RS09565 ENOG4105MPK DNA polymerase III subunit theta HV128_RS09570 ENOG4105FXM Copper resistance protein HV128_RS09575 ENOG4108PNC copper resistance HV128_RS09580 ENOG4105NKT exported protein HV128_RS09590 ENOG4108MJ5 VirK protein HV128_RS09595 ENOG4108R1E Serine threonine protein phosphatase 1 HV128_RS09600 ENOG4105WT8 Protein of unknown function (DUF1480) HV128_RS09605 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HV128_RS09610 ENOG4105DY2 Paraquat-inducible protein b HV128_RS09615 ENOG4105H2K paraquat-inducible protein a HV128_RS09620 ENOG4108ZGC gaf domain protein HV128_RS09625 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HV128_RS09630 ENOG4105CN1 protease HV128_RS09635 ENOG4105D0M Protease HtpX homolog HV128_RS09640 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV128_RS09645 ENOG4105J4Q Transcriptional regulator HV128_RS09650 ENOG4105TIK HV128_RS09655 ENOG4106CCY Protein MgrB homolog HV128_RS09660 ENOG4105Q3Y exported protein HV128_RS09675 ENOG4105CJN penicillin-binding protein HV128_RS09680 ENOG4105DHI Methyltransferase HV128_RS09685 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HV128_RS09690 ENOG4108NK4 UPF0266 membrane protein HV128_RS09695 ENOG4105F3R pts system mannose fructose sorbose family iid HV128_RS09700 ENOG4105ETZ PTS System HV128_RS09705 ENOG4105DAS pts system HV128_RS09710 ENOG4105EE5 Membrane protein terC HV128_RS09715 ENOG4107XTP (EAL) domain protein HV128_RS09720 ENOG4105EJQ L-serine dehydratase HV128_RS09725 ENOG4105P8F nudix hydrolase HV128_RS09730 ENOG4105CRQ synthase (Component I) HV128_RS09735 ENOG4105X5C UPF0181 protein HV128_RS09740 ENOG4105M4H endoribonuclease L-psp HV128_RS09745 ENOG4105DVT helicase HV128_RS09750 ENOG41072GX Peptidase M22 Glycoprotease HV128_RS09755 ENOG4105Y4Z Outer Membrane Lipoprotein HV128_RS09760 ENOG4105CEY Amp-dependent synthetase and ligase HV128_RS09765 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HV128_RS09770 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HV128_RS09775 ENOG4107QMS site-determining protein HV128_RS09780 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HV128_RS09790 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HV128_RS09795 ENOG4108ZZ3 UPF0260 protein HV128_RS09800 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HV128_RS09805 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HV128_RS09815 ENOG4105ED1 spovr family HV128_RS09820 ENOG4105MWK D-amino acid dehydrogenase, small subunit HV128_RS09825 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV128_RS09830 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HV128_RS09835 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HV128_RS09840 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HV128_RS09845 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HV128_RS09850 ENOG4105E0K tonB-dependent siderophore receptor HV128_RS09855 ENOG4105E53 ec 3.2.1.28 HV128_RS09865 ENOG4107RTG Major Facilitator superfamily HV128_RS09895 ENOG4106VK6 Flagellar motor protein HV128_RS09935 ENOG4108WC9 type VI secretion system effector, hcp1 family HV128_RS09985 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV128_RS09990 ENOG4105D9P serine threonine protein kinase HV128_RS10050 ENOG4105C3G gtp-binding protein HV128_RS10055 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HV128_RS10060 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HV128_RS10070 ENOG4105CHH sulfate transporter HV128_RS10075 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HV128_RS10080 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HV128_RS10085 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HV128_RS10090 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HV128_RS10095 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HV128_RS10100 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HV128_RS10105 ENOG4108YY7 Invasion gene expression up-regulator SirB HV128_RS10110 ENOG41063JG Transcriptional regulator HV128_RS10115 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HV128_RS10120 ENOG4105EWV Sodium calcium exchanger membrane region HV128_RS10125 ENOG4105WS7 Cation transport regulator HV128_RS10130 ENOG4108NH8 Cation transport protein HV128_RS10140 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS10145 ENOG41090EX DsrE family HV128_RS10165 ENOG4105D7T ABC transporter HV128_RS10170 ENOG4107QZF nitrite reductase NADPH large subunit HV128_RS10180 ENOG4105ID0 Putative invasin HV128_RS10185 ENOG4105WH1 Two component transcriptional regulator luxr family HV128_RS10190 ENOG4105BZU Histidine kinase HV128_RS10195 ENOG4105DQQ Major facilitator superfamily MFS_1 HV128_RS10200 ENOG4105CRU nitrate reductase, alpha subunit HV128_RS10205 ENOG4108IUE nitrate reductase beta subunit HV128_RS10210 ENOG4105R3A Nitrate reductase HV128_RS10215 ENOG41076YT nitrate reductase, gamma subunit HV128_RS10230 ENOG4105CIY formyltetrahydrofolate deformylase HV128_RS10235 ENOG4105K5B UPF0225 protein HV128_RS10240 ENOG4105D78 K07001 NTE family protein HV128_RS10245 ENOG4105I93 response regulator HV128_RS10250 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV128_RS10260 ENOG4107104 thymidine kinase HV128_RS10265 ENOG4105C0A alcohol dehydrogenase HV128_RS10270 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HV128_RS10275 ENOG4107QSI ABC, transporter HV128_RS10280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV128_RS10285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV128_RS10290 ENOG4105C3U ABC transporter HV128_RS10295 ENOG4108JQ7 (ABC) transporter HV128_RS10300 ENOG4105EYW Ion transport protein HV128_RS10305 ENOG4108W5H UPF0263 protein HV128_RS10310 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HV128_RS10325 ENOG4108NIW Leucine export protein LeuE HV128_RS10330 ENOG4105K9H YciI-like protein HV128_RS10335 ENOG410822N TonB family HV128_RS10340 ENOG4105NAU thioesterase Superfamily protein HV128_RS10345 ENOG4107RNH Outer membrane receptor FepA HV128_RS10350 ENOG4107835 probably involved in intracellular septation (By similarity) HV128_RS10355 ENOG4108S3I UPF0259 membrane protein HV128_RS10360 ENOG4105PI0 Ferredoxin HV128_RS10365 ENOG4105EIF outer membrane protein W HV128_RS10375 ENOG41066VF YeeE YedE family protein HV128_RS10380 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HV128_RS10385 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HV128_RS10390 ENOG4105DK0 Indole-3-glycerol phosphate synthase HV128_RS10395 ENOG4108EFP Anthranilate synthase component II HV128_RS10400 ENOG4105CRQ synthase (Component I) HV128_RS10410 ENOG4105DB7 PHP domain protein HV128_RS10415 ENOG4107RTD sua5 ycio yrdc ywlc family protein HV128_RS10420 ENOG4105FE9 pseudouridine synthase HV128_RS10425 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV128_RS10430 ENOG4105UBK short-chain dehydrogenase reductase HV128_RS10435 ENOG4105ERU peptidase HV128_RS10440 ENOG4105RKX Protein of unknown function (DUF2498) HV128_RS10445 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV128_RS10450 ENOG4107R11 Transcriptional regulator HV128_RS10465 ENOG4107QM5 aconitate hydratase HV128_RS10475 ENOG4105EYK Phosphatidylglycerophosphatase B HV128_RS10480 ENOG4105Q4A inner membrane protein yciS HV128_RS10485 ENOG4105CFV Tetratricopeptide repeat protein HV128_RS10490 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HV128_RS10495 ENOG4108ZJT translation initiation factor, Sui1 HV128_RS10500 ENOG41061RM osmotically inducible lipoprotein HV128_RS10505 ENOG4105N2W Transcriptional regulator HV128_RS10510 ENOG410643D UPF0509 protein HV128_RS10515 ENOG4105E39 Enoyl-CoA hydratase HV128_RS10520 ENOG4105BZU Histidine kinase HV128_RS10525 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HV128_RS10530 ENOG4105Q4T oxidoreductase HV128_RS10535 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HV128_RS10540 ENOG4105BZU Histidine kinase HV128_RS10550 ENOG4108UQ8 endoribonuclease L-psp HV128_RS10560 ENOG4108JQ2 peptide transport system atp-binding protein HV128_RS10565 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HV128_RS10570 ENOG4108EU3 peptide transport system, permease HV128_RS10575 ENOG4108EKA peptide transport system, permease HV128_RS10580 ENOG4108J59 Extracellular solute-binding protein, family 5 HV128_RS10585 ENOG4105E51 psp operon transcriptional activator HV128_RS10590 ENOG41087YS Phage shock protein A HV128_RS10595 ENOG4105YYT phage shock protein B HV128_RS10600 ENOG4105FM1 phage shock protein C HV128_RS10605 ENOG4105NNG Peripheral inner membrane phage-shock protein HV128_RS10610 ENOG4107QW3 Sucrose phosphorylase HV128_RS10615 ENOG4105WEM extracellular solute-binding protein HV128_RS10620 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HV128_RS10625 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HV128_RS10630 ENOG4107RRD Dehydrogenase HV128_RS10635 ENOG4107TYA transient receptor potential locus HV128_RS10640 ENOG4105CK5 oxidoreductase HV128_RS10645 ENOG4105C71 hydrolase family 65, central catalytic HV128_RS10650 ENOG4107URF beta-phospho-glucomutase HV128_RS10655 ENOG4108IJ9 (ABC) transporter HV128_RS10660 ENOG4107EFV Outer membrane protein G HV128_RS10665 ENOG4105FKQ transcriptional regulator HV128_RS10670 ENOG4105CM6 amino acid regulated cytosolic protein HV128_RS10675 ENOG4106K28 UPF0283 membrane protein HV128_RS10680 ENOG4108JU8 Transcriptional regulator HV128_RS10685 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HV128_RS10690 ENOG4107S8C mandelate racemase muconate lactonizing HV128_RS10695 ENOG4105KXI murein peptide amidase A HV128_RS10700 ENOG4107QSI ABC, transporter HV128_RS10725 ENOG4108ZG0 Ompa motb domain protein HV128_RS10735 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV128_RS10750 ENOG4105CS6 Rhs element vgr protein HV128_RS10775 ENOG4105F9F transposase HV128_RS10790 ENOG4105W1Y Transcriptional regulator HV128_RS10860 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS10865 ENOG4107RX3 Mg2 transporter protein cora family protein HV128_RS10875 ENOG4105C1J atp-dependent rna helicase HV128_RS10880 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HV128_RS10885 ENOG4107R08 Integrase HV128_RS10905 ENOG4105FCK Membrane HV128_RS10910 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HV128_RS10915 ENOG4105IKK cytoplasmic protein HV128_RS10920 ENOG41090X5 Heat shock protein hslJ HV128_RS10930 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV128_RS10935 ENOG4105C4M (Ubiquinol oxidase) subunit I HV128_RS10945 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV128_RS10950 ENOG4105C26 Dehydrogenase HV128_RS10955 ENOG4105YP6 Domain of unknown function (DUF1869) HV128_RS10960 ENOG4108YS1 cytoplasmic protein HV128_RS10965 ENOG4108YS1 cytoplasmic protein HV128_RS10970 ENOG410654E Membrane HV128_RS10995 ENOG4105DEF Extracellular solute-binding protein, family 5 HV128_RS11000 ENOG4105R71 cytoplasmic protein HV128_RS11005 ENOG4108T9Y Inner membrane protein ydcZ HV128_RS11010 ENOG4108Z7F N-acetyltransferase HV128_RS11020 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HV128_RS11025 ENOG4108WYP Transcriptional regulator HV128_RS11030 ENOG4105CHB tonB-dependent Receptor HV128_RS11035 ENOG4108NS2 receptor HV128_RS11040 ENOG4105C85 amino acid HV128_RS11045 ENOG4105EQ2 LysR family Transcriptional regulator HV128_RS11055 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV128_RS11060 ENOG4105DEN Luciferase family HV128_RS11075 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HV128_RS11090 ENOG4105CDA abc transporter atp-binding protein HV128_RS11100 ENOG4108N27 Glutathione S-transferase HV128_RS11105 ENOG4105KZK Tautomerase pptA HV128_RS11110 ENOG4105D1S lipid A biosynthesis HV128_RS11120 ENOG4105YVS arsR family transcriptional regulator HV128_RS11125 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HV128_RS11130 ENOG4108MEJ flavin reductase domain protein HV128_RS11135 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HV128_RS11140 ENOG4106DRA Inner membrane protein YidI HV128_RS11145 ENOG4105D0D Nitrate reductase 2, gamma subunit HV128_RS11150 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HV128_RS11155 ENOG4108IUE nitrate reductase beta subunit HV128_RS11160 ENOG4105CRU nitrate reductase, alpha subunit HV128_RS11165 ENOG4107QND Nitrite extrusion protein HV128_RS11180 ENOG4105FCK Membrane HV128_RS11195 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV128_RS11200 ENOG4108MG3 formate dehydrogenase HV128_RS11210 ENOG4105F27 Major Facilitator HV128_RS11225 ENOG4105DQ4 alcohol dehydrogenase HV128_RS11230 ENOG4105C5H ABC transporter HV128_RS11235 ENOG4107R1I NAD-dependent malic enzyme HV128_RS11245 ENOG4105TPS biofilm-dependent modulation protein HV128_RS11260 ENOG4105EXG Transcriptional regulator HV128_RS11265 ENOG4108Z9K Osmotically inducible protein HV128_RS11270 ENOG4107H6U ABC transporter HV128_RS11275 ENOG4105C3U ABC transporter HV128_RS11280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV128_RS11285 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV128_RS11290 ENOG4105DEF Extracellular solute-binding protein, family 5 HV128_RS11295 ENOG4108UQS dipeptidase HV128_RS11300 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) HV128_RS11310 ENOG4105BZU Histidine kinase HV128_RS11315 ENOG4105D7K pfkb domain protein HV128_RS11320 ENOG4108M0B Sucrose porin HV128_RS11335 ENOG4105WBN Transcriptional regulator (LacI family HV128_RS11370 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HV128_RS11375 ENOG4105F32 YngK protein HV128_RS11380 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HV128_RS11385 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV128_RS11390 ENOG4107RSM transcriptional regulator HV128_RS11400 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HV128_RS11405 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV128_RS11415 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV128_RS11450 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV128_RS11475 ENOG4105E98 transcriptional regulator DeoR family HV128_RS11480 ENOG4107VIJ nudix hydrolase HV128_RS11495 ENOG4105E0F Histidine kinase HV128_RS11505 ENOG4105CPT Alpha beta hydrolase HV128_RS11525 ENOG4105FFC UPF0187 protein HV128_RS11530 ENOG4107QZW Altronate oxidoreductase HV128_RS11540 ENOG4105BZU Histidine kinase HV128_RS11545 ENOG4105M0C cytoplasmic protein HV128_RS11550 ENOG4105CSV Glutaminase HV128_RS11555 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS11560 ENOG4105C26 Dehydrogenase HV128_RS11565 ENOG4105EGI Transcriptional regulator HV128_RS11570 ENOG4105JAB phenazine biosynthesis protein, phzf family HV128_RS11575 ENOG4105JAB phenazine biosynthesis protein, phzf family HV128_RS11580 ENOG4105F27 Major Facilitator HV128_RS11585 ENOG41082NP Multiple antibiotic resistance HV128_RS11590 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HV128_RS11595 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HV128_RS11600 ENOG4106DNR multiple antibiotic resistance protein HV128_RS11605 ENOG4108594 Permease of the drug metabolite transporter HV128_RS11610 ENOG4105E5W Transporter HV128_RS11615 ENOG4108MEK Metal-binding protein YodA HV128_RS11620 ENOG4108IV0 ABC, transporter HV128_RS11625 ENOG4108JJB ABC transporter HV128_RS11635 ENOG4105C32 Amino acid ABC transporter (Permease) HV128_RS11655 ENOG4105ECQ AraC Family Transcriptional Regulator HV128_RS11665 ENOG4105RR0 Protein of unknown function (DUF2554) HV128_RS11670 ENOG4105CFP Peptidase U32 HV128_RS11675 ENOG4108JCI Transcriptional regulator HV128_RS11680 ENOG4105DKK Benzoate HV128_RS11695 ENOG4108KKZ (LipO)protein HV128_RS11700 ENOG4105DEF Extracellular solute-binding protein, family 5 HV128_RS11705 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HV128_RS11710 ENOG41088CC tellurite resistance protein tehB HV128_RS11715 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HV128_RS11720 ENOG4107WE3 acetyltransferase YdcK HV128_RS11725 ENOG4108Z9I -acetyltransferase HV128_RS11730 ENOG4105DJ9 glucan biosynthesis protein HV128_RS11735 ENOG4105E89 ABC transporter HV128_RS11740 ENOG4105CHM Aminotransferase HV128_RS11755 ENOG4105E32 cytoplasmic protein HV128_RS11760 ENOG4105DDW LysR family Transcriptional regulator HV128_RS11765 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS11805 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HV128_RS11835 ENOG4108JJA ABC, transporter HV128_RS11850 ENOG4105E98 transcriptional regulator DeoR family HV128_RS11855 ENOG4105D9R oxidoreductase HV128_RS11860 ENOG4105CPW cytochrome b561 HV128_RS11865 ENOG4105C26 Dehydrogenase HV128_RS11870 ENOG4107DB1 DUF218 domain HV128_RS11885 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HV128_RS11890 ENOG4105CQ7 ATP-dependent helicase HV128_RS11895 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HV128_RS11900 ENOG4105D3G Pseudouridine synthase HV128_RS11905 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HV128_RS11915 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HV128_RS11950 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV128_RS11965 ENOG4107FW0 short-chain dehydrogenase reductase HV128_RS11985 ENOG4105EUZ Beta-lactamase domain protein HV128_RS11995 ENOG4108Z0R Transferase HV128_RS12000 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HV128_RS12005 ENOG4105DZS Phenylacetate-CoA ligase HV128_RS12010 ENOG4105CHU acetyl-coa acetyltransferase HV128_RS12015 ENOG4108ZJI phenylacetic acid degradation protein HV128_RS12020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV128_RS12025 ENOG4108UKI Enoyl-CoA hydratase HV128_RS12030 ENOG4105E39 Enoyl-CoA hydratase HV128_RS12035 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV128_RS12040 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HV128_RS12045 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HV128_RS12050 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HV128_RS12055 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HV128_RS12060 ENOG4105DXM phenylacetic acid degradation protein HV128_RS12080 ENOG4105F11 amine oxidase HV128_RS12085 ENOG4105EUZ Beta-lactamase domain protein HV128_RS12095 ENOG4105C26 Dehydrogenase HV128_RS12100 ENOG4108WFR AraC Family Transcriptional Regulator HV128_RS12105 ENOG4105WXT Conserved Protein HV128_RS12110 ENOG410689M (LipO)protein HV128_RS12120 ENOG4105C5I Dehydrogenase HV128_RS12130 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HV128_RS12145 ENOG4105DZG Dehydrogenase HV128_RS12155 ENOG4105C44 Serine transporter HV128_RS12160 ENOG4105Y50 Virulence Protein HV128_RS12180 ENOG4105EWC Purine nucleoside phosphorylase HV128_RS12185 ENOG4105DGW oligopeptidase A HV128_RS12190 ENOG4105EMU Dehydrogenase HV128_RS12195 ENOG4107XBN GntR Family Transcriptional Regulator HV128_RS12200 ENOG4108U51 Universal stress protein HV128_RS12205 ENOG41061EV selenium-binding protein YdfZ HV128_RS12210 ENOG4105DEI Mannitol dehydrogenase HV128_RS12220 ENOG4105CPQ Dehydrogenase HV128_RS12225 ENOG4105CXK mandelate racemase muconate lactonizing HV128_RS12230 ENOG4105KK4 UPF0060 membrane protein HV128_RS12235 ENOG4105M5Q UPF0482 protein HV128_RS12240 ENOG4108MK9 spermidine N(1)-acetyltransferase HV128_RS12255 ENOG4105KBG Protein of unknown function (DUF1161) HV128_RS12265 ENOG4105QAX Iron-sulfur HV128_RS12270 ENOG4107KGK dmso reductase anchor subunit HV128_RS12275 ENOG4108NEM leader-binding protein dmsD HV128_RS12280 ENOG4105X2V dna damage-inducible protein HV128_RS12290 ENOG4108UY2 Chloramphenicol acetyltransferase HV128_RS12295 ENOG4105EQ2 LysR family Transcriptional regulator HV128_RS12300 ENOG4105ENX hydrolase HV128_RS12305 ENOG4107RTG Major Facilitator superfamily HV128_RS12315 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HV128_RS12320 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV128_RS12325 ENOG4105E90 ABC transporter HV128_RS12330 ENOG4108IJ8 ABC transporter HV128_RS12335 ENOG4105CMQ Chloride channel HV128_RS12340 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV128_RS12345 ENOG4105DAG ROK family HV128_RS12350 ENOG4106NZI LysR family Transcriptional regulator HV128_RS12355 ENOG4105D94 Major Facilitator Superfamily HV128_RS12360 ENOG4105CTD carboxy-peptidase HV128_RS12375 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HV128_RS12380 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) HV128_RS12385 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HV128_RS12390 ENOG4105DSF transport protein HV128_RS12400 ENOG4108M8W Monooxygenase HV128_RS12405 ENOG4105N1F Hnh endonuclease HV128_RS12410 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV128_RS12415 ENOG4108IGT Dipeptidase HV128_RS12425 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HV128_RS12445 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF HV128_RS12450 ENOG4105DZG Dehydrogenase HV128_RS12455 ENOG4105KT5 UmuD protein HV128_RS12465 ENOG4107S5I aldo keto reductase HV128_RS12470 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS12475 ENOG4108DG9 Smr protein MutS2 HV128_RS12480 ENOG4106KR7 LysR family Transcriptional regulator HV128_RS12490 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HV128_RS12495 ENOG4105CFC Transporter HV128_RS12500 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV128_RS12505 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV128_RS12510 ENOG4105Q9Y Universal stress protein HV128_RS12515 ENOG4105D64 Mechanosensitive ion channel HV128_RS12520 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV128_RS12525 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV128_RS12530 ENOG4105C5D exported protein HV128_RS12535 ENOG4105D5Q Arginine ornithine antiporter HV128_RS12540 ENOG410642E Short chain dehydrogenase HV128_RS12545 ENOG4105RA2 Membrane HV128_RS12550 ENOG4107EXC regulatoR HV128_RS12555 ENOG41066T8 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity) HV128_RS12560 ENOG4105VEQ Cold shock protein HV128_RS12570 ENOG4105JJR Histidine kinase HV128_RS12575 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HV128_RS12580 ENOG4105C9Q fumarate hydratase class II HV128_RS12585 ENOG4107GFK fumarate HV128_RS12590 ENOG4105EIP mannose-6-phosphate isomerase HV128_RS12595 ENOG4106J39 exported protein HV128_RS12600 ENOG4107P2S Transcriptional regulator HV128_RS12770 ENOG4108N0N Phage Terminase Large Subunit HV128_RS12775 ENOG41061CV Terminase small subunit HV128_RS12785 ENOG4106050 phage regulatory protein, rha family HV128_RS12790 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HV128_RS12820 ENOG4108R1E Serine threonine protein phosphatase 1 HV128_RS12830 ENOG4105NY2 NinB protein HV128_RS12970 ENOG4107R08 Integrase HV128_RS12980 ENOG4105C87 Aminotransferase class I and II HV128_RS12985 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HV128_RS12990 ENOG4105D9R oxidoreductase HV128_RS12995 ENOG4106C6R beta-lactam resistance protein HV128_RS13005 ENOG4105M9B inner membrane protein ydgK HV128_RS13010 ENOG4105DGN Electron transport complex HV128_RS13025 ENOG4105D6A Electron transport complex HV128_RS13030 ENOG4108UQQ Electron transport complex HV128_RS13040 ENOG4105CSM endonuclease III HV128_RS13045 ENOG4105DUX Transporter HV128_RS13050 ENOG4108K3A Glutathione S-transferase HV128_RS13055 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV128_RS13060 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HV128_RS13065 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HV128_RS13070 ENOG410642K Lysozyme inhibitor HV128_RS13075 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HV128_RS13080 ENOG4108XTF Outer Membrane Lipoprotein HV128_RS13085 ENOG4105BZU Histidine kinase HV128_RS13100 ENOG4105Y49 secretion protein, HlyD family HV128_RS13105 ENOG4105DSW Fusaric acid resistance protein HV128_RS13110 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV128_RS13115 ENOG4107RGM aldo keto reductase HV128_RS13120 ENOG4105XZD Fe-S protein HV128_RS13125 ENOG4105DIJ Phosphoethanolamine transferase HV128_RS13130 ENOG4108WUH Transcriptional regulator, TetR family HV128_RS13135 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV128_RS13140 ENOG4108UYE Lactoylglutathione lyase HV128_RS13145 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HV128_RS13150 ENOG4105M2J Glutaredoxin HV128_RS13155 ENOG4105K4H Nlp p60 protein HV128_RS13160 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV128_RS13165 ENOG4105F27 Major Facilitator HV128_RS13175 ENOG4105ETE Transcriptional regulator (LacI family HV128_RS13180 ENOG4105F52 Transcriptional regulator HV128_RS13185 ENOG4105CZQ inner membrane transport protein YdhC HV128_RS13190 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV128_RS13195 ENOG4108R6K riboflavin synthase, subunit alpha HV128_RS13215 ENOG4108ZNX Heat shock protein HV128_RS13225 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HV128_RS13230 ENOG4107B2H carbonic anhydrase HV128_RS13255 ENOG4106TNF Periplasmic binding protein HV128_RS13265 ENOG4105E5Q amino acid AbC transporter HV128_RS13270 ENOG4105DRP amino acid AbC transporter HV128_RS13275 ENOG4105RFR Protein of unknown function (DUF2767) HV128_RS13280 ENOG4105D01 (LipO)protein HV128_RS13285 ENOG4108UMI ABC transporter, permease HV128_RS13300 ENOG4105C28 cystathionine HV128_RS13305 ENOG4105CA9 Pyruvate kinase HV128_RS13315 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV128_RS13320 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV128_RS13325 ENOG4105C9B Cysteine desulfurase HV128_RS13330 ENOG4105JRK feS assembly protein SufD HV128_RS13335 ENOG4105C3K feS assembly ATPase SufC HV128_RS13340 ENOG4105DIW FeS assembly protein SUFB HV128_RS13345 ENOG4108Z4V iron-sulfur cluster assembly HV128_RS13360 ENOG4108XDN Transcriptional regulator HV128_RS13365 ENOG4105BZU Histidine kinase HV128_RS13370 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HV128_RS13385 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HV128_RS13395 ENOG4108T65 Fimbrial HV128_RS13405 ENOG4105CW0 outer membrane usher protein HV128_RS13410 ENOG4108VCD Chaperone HV128_RS13420 ENOG4108PNB DNA-binding transcriptional regulator HV128_RS13425 ENOG4108PNB DNA-binding transcriptional regulator HV128_RS13430 ENOG410671Z uncharacterized protein ydiH HV128_RS13435 ENOG4105KA0 thioesterase Superfamily protein HV128_RS13440 ENOG4105CQB FAD linked oxidase domain protein HV128_RS13445 ENOG4105IPI Membrane HV128_RS13455 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HV128_RS13460 ENOG4105CT4 transporter HV128_RS13465 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HV128_RS13470 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HV128_RS13475 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV128_RS13485 ENOG4107ENK receptor HV128_RS13490 ENOG4106QJH hemin transport protein HV128_RS13495 ENOG4107R4I Periplasmic binding protein HV128_RS13500 ENOG4105EHG Permease protein HV128_RS13505 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HV128_RS13510 ENOG4105CNG UPF0061 protein HV128_RS13515 ENOG4108TC0 Diguanylate phosphodiesterase HV128_RS13520 ENOG4108QBX (LipO)protein HV128_RS13525 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HV128_RS13530 ENOG4108V06 Glutathione peroxidase HV128_RS13540 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV128_RS13545 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HV128_RS13550 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HV128_RS13565 ENOG41082NX 50s ribosomal protein l35 HV128_RS13570 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HV128_RS13590 ENOG4105VR4 UPF0379 protein ybiJ HV128_RS13595 ENOG4108NE3 Salt-induced outer membrane protein HV128_RS13600 ENOG4105DE4 1-phosphofructokinase HV128_RS13605 ENOG4105P10 Uncharacterized protein ydiZ HV128_RS13615 ENOG4107PN8 YfeABCD locus regulator HV128_RS13620 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HV128_RS13625 ENOG4105CHR reductase HV128_RS13630 ENOG4107K5X Membrane-bound metal-dependent hydrolase HV128_RS13635 ENOG4108ETY sodium dicarboxylate symporter HV128_RS13645 ENOG4105CH6 catalase HV128_RS13650 ENOG410901P UPF0249 protein HV128_RS13655 ENOG4105F8D glycoside hydrolase family 4 HV128_RS13660 ENOG4105EZV Transcriptional regulator HV128_RS13665 ENOG4105VCP PTS System HV128_RS13670 ENOG4105CK1 PTS System HV128_RS13675 ENOG4105VZJ PTS System HV128_RS13680 ENOG4105KKI DNA-binding transcriptional activator OsmE HV128_RS13690 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HV128_RS13695 ENOG41090B9 response to stress HV128_RS13700 ENOG4108SPG Periplasmic Protein HV128_RS13710 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HV128_RS13715 ENOG4105C26 Dehydrogenase HV128_RS13720 ENOG4105F4X arginine HV128_RS13725 ENOG4105C8Y Acetylornithine aminotransferase HV128_RS13730 ENOG4105CGK Exodeoxyribonuclease III HV128_RS13740 ENOG4105VNH ABC transporter solute-binding protein HV128_RS13745 ENOG4105CXZ ABC transporter, permease HV128_RS13750 ENOG4108VGW abc transporter atp-binding protein HV128_RS13755 ENOG4107RM6 sulfurtransferase HV128_RS13760 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HV128_RS13765 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV128_RS13770 ENOG4105M6F mutator MutT protein HV128_RS13775 ENOG4105MTM Protein of unknown function (DUF1496) HV128_RS13780 ENOG4105D82 Glutamate dehydrogenase HV128_RS13785 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV128_RS13790 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HV128_RS13795 ENOG41069NU Nitroreductase HV128_RS13800 ENOG4105D07 Signal peptide peptidase, SppA HV128_RS13805 ENOG4105HDK L-asparaginase HV128_RS13810 ENOG4108RWI nicotinamidase HV128_RS13820 ENOG4105VUT cytoplasmic protein HV128_RS13830 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV128_RS13835 ENOG4105DSB aldose 1-epimerase HV128_RS13840 ENOG4105GNX MltA-interacting MipA family protein HV128_RS13845 ENOG4105CYN Serine protein kinase HV128_RS13850 ENOG4106AKX UPF0229 protein HV128_RS13865 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HV128_RS13870 ENOG4105CKK Glycosyl transferase, family 2 HV128_RS13890 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HV128_RS13895 ENOG4105CT4 transporter HV128_RS13905 ENOG4108VMM UPF0756 membrane protein HV128_RS13910 ENOG4105R1U AraC Family Transcriptional Regulator HV128_RS13915 ENOG4105DJ2 Major Facilitator Superfamily HV128_RS13920 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HV128_RS13925 ENOG4105K78 MarR family Transcriptional regulator HV128_RS13935 ENOG4105UCG Domain of unknown function (DUF333) HV128_RS13940 ENOG410620I Diguanylate cyclase HV128_RS13945 ENOG4106G4W HV128_RS13955 ENOG4105Y3U Transglycosylase-associated protein HV128_RS13965 ENOG41066DG (EAL) domain protein HV128_RS13970 ENOG4105N0E Protein of unknown function (DUF2543) HV128_RS13975 ENOG4108HMX isocitrate dehydrogenase (NADP) HV128_RS13980 ENOG4108R99 pseudouridine synthase HV128_RS13995 ENOG41075W9 High frequency lysogenization protein HflD homolog HV128_RS14000 ENOG4107QTF adenylosuccinate lyase HV128_RS14010 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV128_RS14015 ENOG4105IFJ Histidine kinase HV128_RS14020 ENOG4105EZE Cupin 4 family protein HV128_RS14025 ENOG4108UK5 Transposase HV128_RS14030 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HV128_RS14045 ENOG4108EG7 Binding-protein-dependent transport systems, inner membrane component HV128_RS14050 ENOG4108HM4 ABC transporter HV128_RS14055 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HV128_RS14060 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HV128_RS14065 ENOG4105D60 lipoprotein releasing system transmembrane protein HV128_RS14070 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HV128_RS14075 ENOG4105D60 lipoprotein releasing system transmembrane protein HV128_RS14080 ENOG4105IQC Inner membrane protein YcfT HV128_RS14085 ENOG4108JA2 transcriptioN-repair coupling factor HV128_RS14090 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV128_RS14095 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HV128_RS14100 ENOG4108IND Tetr family transcriptional regulator HV128_RS14105 ENOG4107MBR 17 kDa surface antigen HV128_RS14110 ENOG4105CEP NADH dehydrogenase HV128_RS14115 ENOG4105D0Y UPF0227 protein HV128_RS14130 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HV128_RS14135 ENOG41090DQ Lipoprotein HV128_RS14140 ENOG4105K59 histidine triad (HIT) protein HV128_RS14145 ENOG4105CNM Receptor HV128_RS14150 ENOG4105CI1 PTS System HV128_RS14155 ENOG4105F8V Hydrolase, tatD family HV128_RS14160 ENOG4107QRG dna polymerase iii HV128_RS14170 ENOG4105HHA aminodeoxychorismate lyase HV128_RS14175 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HV128_RS14180 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV128_RS14185 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HV128_RS14190 ENOG4105CHR reductase HV128_RS14195 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV128_RS14200 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HV128_RS14205 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HV128_RS14210 ENOG4105VGS 50s ribosomal protein l32 HV128_RS14215 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HV128_RS14220 ENOG4108UHJ MAF-like protein HV128_RS14225 ENOG4105EI2 Pseudouridine synthase HV128_RS14230 ENOG4107QQB Ribonuclease E HV128_RS14235 ENOG4105EJC lysr family transcriptional regulator HV128_RS14240 ENOG4105EQ0 Major Facilitator superfamily HV128_RS14245 ENOG4105DTJ flagellar hook-associated protein HV128_RS14250 ENOG4105E1Q flagellar hook-associated protein HV128_RS14255 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HV128_RS14270 ENOG4105CGA flagellar basal-body rod protein FlgG HV128_RS14275 ENOG4108KPB Flagellar basal-body rod protein FlgF HV128_RS14280 ENOG4105BZE flagellar hook protein, FlgE HV128_RS14285 ENOG4105W00 Flagellar hook capping protein HV128_RS14290 ENOG4108ZC9 flagellar basal-body rod protein flgc HV128_RS14295 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HV128_RS14300 ENOG4105CKS Flagella basal body P-ring formation protein flgA HV128_RS14305 ENOG4105M9M anti-sigma28 factor FlgM HV128_RS14310 ENOG4105QVD Flagella synthesis protein FlgN HV128_RS14315 ENOG4105CJR Integral membrane protein (MviN HV128_RS14320 ENOG4105EP9 oxidoreductase HV128_RS14325 ENOG4108YXG UPF0502 protein HV128_RS14330 ENOG4105D9U N-acetyltransferase HV128_RS14335 ENOG4105EV4 Multidrug resistance protein mdtH HV128_RS14340 ENOG4105F3T (LipO)protein HV128_RS14345 ENOG4105EKE dihydroorotase HV128_RS14350 ENOG4105MEA DNA damage-inducible protein i HV128_RS14355 ENOG4105PVA Biofilm formation regulatory protein BssS HV128_RS14360 ENOG4105F76 Sarcosine oxidase HV128_RS14365 ENOG4106974 biofilm formation HV128_RS14370 ENOG4105DS1 cytochrome b561 HV128_RS14375 ENOG4108YYC ycei family HV128_RS14380 ENOG4105C72 UPF0176 protein HV128_RS14385 ENOG4105D1S lipid A biosynthesis HV128_RS14390 ENOG4105C6X Major Facilitator HV128_RS14395 ENOG4108W47 Acidic protein msyB HV128_RS14400 ENOG4105NAC (LipO)protein HV128_RS14405 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HV128_RS14420 ENOG4108UVJ appr-1-p processing domain protein HV128_RS14430 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HV128_RS14435 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HV128_RS14440 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HV128_RS14445 ENOG41086KC Transcriptional regulator HV128_RS14450 ENOG4108XDW curli assembly protein CsgE HV128_RS14455 ENOG4108WYR Curli production assembly transport component, CsgF HV128_RS14460 ENOG4105P8Q Curli production assembly transport component CsgG HV128_RS14465 ENOG4108UQ5 membrane protein YcdZ HV128_RS14470 ENOG4107XHZ cytoplasmic chaperone TorD family protein HV128_RS14475 ENOG4107SSZ Phosphatase HV128_RS14480 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HV128_RS14495 ENOG4105CR8 Transcriptional regulator HV128_RS14500 ENOG4105EUB pirin domain protein HV128_RS14505 ENOG4105CHJ isochorismatase hydrolase HV128_RS14515 ENOG4105D5M phosphate starvation-inducible protein HV128_RS14520 ENOG4105DBE peroxidase HV128_RS14525 ENOG410650H (LipO)protein HV128_RS14535 ENOG4105D9N nucleoside HV128_RS14545 ENOG4105CK7 Sodium proline symporter HV128_RS14550 ENOG4105C26 Dehydrogenase HV128_RS14560 ENOG4108R86 Transcriptional regulator HV128_RS14565 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HV128_RS14570 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HV128_RS14575 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) HV128_RS14580 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HV128_RS14585 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HV128_RS14590 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HV128_RS14595 ENOG4105C2W permease HV128_RS14615 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HV128_RS14620 ENOG4105CS1 NAD(P)H quinone oxidoreductase HV128_RS14625 ENOG4105XH3 HV128_RS14630 ENOG4105D6F Phosphatase HV128_RS14635 ENOG4105KVH Transcriptional regulator HV128_RS14640 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HV128_RS14645 ENOG4107T5V SNARE associated Golgi HV128_RS14650 ENOG4105CJW magnesium transporter HV128_RS14665 ENOG4105EGS Mechanosensitive ion channel HV128_RS14675 ENOG4105EHG Permease protein HV128_RS14680 ENOG4105E0A ABC, transporter HV128_RS14690 ENOG4107QSI ABC, transporter HV128_RS14695 ENOG4108MN8 Membrane HV128_RS14705 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HV128_RS14710 ENOG4105DR4 Methyltransferase HV128_RS14715 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HV128_RS14720 ENOG4105K4P CoA-binding domain protein HV128_RS14725 ENOG4108Q67 UPF0319 protein HV128_RS14730 ENOG4108Z5K methylglyoxal synthase HV128_RS14735 ENOG41088T4 Helicase IV HV128_RS14740 ENOG410901E Membrane HV128_RS14745 ENOG4105EM2 membrane HV128_RS14750 ENOG4108RZ1 DNA transformation protein HV128_RS14755 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) HV128_RS14760 ENOG4105UYK outer membrane protein a HV128_RS14765 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HV128_RS14770 ENOG4105DAN ATP-dependent protease HV128_RS14780 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HV128_RS14785 ENOG4108Q2G (LipO)protein HV128_RS14790 ENOG4105DY2 Paraquat-inducible protein b HV128_RS14795 ENOG4105F1S paraquat-inducible protein a HV128_RS14800 ENOG4105C5H ABC transporter HV128_RS14805 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HV128_RS14810 ENOG4105QVC MOSC domain-containing protein HV128_RS14815 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HV128_RS14820 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HV128_RS14825 ENOG4108UZX fmn reductase HV128_RS14830 ENOG4105GVF (ABC) transporter HV128_RS14835 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HV128_RS14840 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HV128_RS14850 ENOG4105CD8 aminopeptidase N HV128_RS14855 ENOG4107RH7 Nicotinate phosphoribosyltransferase HV128_RS14860 ENOG4105C5S asparaginyl-tRNA synthetase HV128_RS14870 ENOG4105CGF Aromatic amino acid aminotransferase HV128_RS14875 ENOG4105C5X domain protein HV128_RS14880 ENOG4105EAQ (twin-arginine translocation) pathway signal HV128_RS14885 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HV128_RS14890 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HV128_RS14895 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HV128_RS14900 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HV128_RS14905 ENOG4106371 Methyltransferase HV128_RS14910 ENOG4107S90 membrAne HV128_RS14915 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HV128_RS14920 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HV128_RS14925 ENOG4105W49 UPF0434 protein HV128_RS14930 ENOG4105T0Z Conserved Protein HV128_RS14935 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HV128_RS14940 ENOG4105BZ1 (ABC) transporter HV128_RS14945 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HV128_RS14950 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV128_RS14955 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HV128_RS14960 ENOG4105CAT Cytidine monophosphate kinase HV128_RS14965 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HV128_RS14970 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HV128_RS14975 ENOG4107VMU Membrane HV128_RS14980 ENOG4105DDY UPF0142 protein ycaO HV128_RS14985 ENOG4105TMB Formate nitrite transporter HV128_RS14990 ENOG4105C6N Formate acetyltransferase HV128_RS14995 ENOG4105F1A Pyruvate formate-lyase HV128_RS15005 ENOG4108ISG Major Facilitator HV128_RS15010 ENOG4107KGK dmso reductase anchor subunit HV128_RS15015 ENOG4105QAX Iron-sulfur HV128_RS15020 ENOG4107QY8 reductase HV128_RS15025 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HV128_RS15030 ENOG4105D1H recombination factor protein RarA HV128_RS15035 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HV128_RS15040 ENOG4105CNU cell division protein FtsK HV128_RS15045 ENOG4105EW9 transcriptional regulator AsnC family HV128_RS15050 ENOG4105C3M thioredoxin reductase HV128_RS15055 ENOG4108JJ9 ABC, transporter HV128_RS15060 ENOG4108JJ8 (ABC) transporter HV128_RS15065 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HV128_RS15090 ENOG4105M6W Crispr-associated protein, Csy3 family HV128_RS15095 ENOG4105DZX CRISPR-associated protein, Csy2 family HV128_RS15100 ENOG4105ENG CRISPR-associated protein, Csy1 family HV128_RS15105 ENOG4107IIZ CRISPR-associated helicase, Cas3 HV128_RS15110 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HV128_RS15120 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV128_RS15125 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HV128_RS15130 ENOG4105VEQ Cold shock protein HV128_RS15140 ENOG4105DJY efflux transporter, rnd family, mfp subunit HV128_RS15145 ENOG4108MJ5 VirK protein HV128_RS15150 ENOG4105CPB ATP-dependent endonuclease of the OLD family HV128_RS15155 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV128_RS15160 ENOG4105DWU Membrane HV128_RS15165 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HV128_RS15170 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV128_RS15175 ENOG4105C7K acetolactate synthase HV128_RS15180 ENOG4105C5W Aldolase HV128_RS15185 ENOG4105CGD Nad-dependent epimerase dehydratase HV128_RS15190 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HV128_RS15235 ENOG4105X5Z General secretion pathway protein I HV128_RS15245 ENOG4108VAU general secretion pathway protein G HV128_RS15250 ENOG4105D7Q type ii secretion system HV128_RS15255 ENOG4107QHF type ii secretion system protein e HV128_RS15260 ENOG4105GVR general secretion pathway protein D HV128_RS15265 ENOG4108XKW General secretion pathway protein C HV128_RS15280 ENOG4108PNB DNA-binding transcriptional regulator HV128_RS15285 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV128_RS15290 ENOG4105K8R UPF0145 protein HV128_RS15295 ENOG41064MM (LipO)protein HV128_RS15300 ENOG4105E5Z arginine transporter ATP-binding subunit HV128_RS15305 ENOG4106PMH Extracellular solute-binding protein family 3 HV128_RS15310 ENOG4105GBT ABC transporter HV128_RS15315 ENOG4105DMR ABC, transporter HV128_RS15320 ENOG4106TNF Periplasmic binding protein HV128_RS15325 ENOG4105BZU Histidine kinase HV128_RS15330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV128_RS15335 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HV128_RS15340 ENOG4105RBQ inner membrane protein ybjO HV128_RS15345 ENOG4105D38 putrescine abc transporter HV128_RS15350 ENOG4105F38 ABC transporter, permease HV128_RS15355 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV128_RS15360 ENOG4107RUE extracellular solute-binding protein family 1 HV128_RS15365 ENOG4108RMJ sensory transduction regulator HV128_RS15370 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HV128_RS15375 ENOG4108DBC nitroreductase HV128_RS15380 ENOG41090BQ Glutaredoxin HV128_RS15385 ENOG4105GWF inner membrane protein YbjM HV128_RS15395 ENOG4105KBH arsR family transcriptional regulator HV128_RS15410 ENOG4108RFG Tetr family transcriptional regulator HV128_RS15415 ENOG4106UW1 Major Facilitator superfamily HV128_RS15420 ENOG4108HCJ Hydrolase HV128_RS15425 ENOG4107QF7 multi-drug HV128_RS15435 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HV128_RS15440 ENOG4107FB0 transcriptional regulator DeoR family HV128_RS15445 ENOG4105DZ1 carboxypeptidase HV128_RS15450 ENOG4108TGY Glutathione S-transferase HV128_RS15455 ENOG4105D8V Glucose sorbosone dehydrogenase HV128_RS15460 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HV128_RS15465 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HV128_RS15485 ENOG4108JQ6 ABC transporter HV128_RS15490 ENOG4105D44 asparaginase HV128_RS15495 ENOG4105CVM Molybdenum cofactor synthesis domain protein HV128_RS15500 ENOG4105D06 uba thif-type nad fad binding protein HV128_RS15505 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV128_RS15510 ENOG4105F1A Pyruvate formate-lyase HV128_RS15520 ENOG4108HCJ Hydrolase HV128_RS15525 ENOG41072TH Protein of unknown function (DUF1479) HV128_RS15530 ENOG4105ETE Transcriptional regulator (LacI family HV128_RS15535 ENOG4105DPW Major facilitator superfamily MFS_1 HV128_RS15545 ENOG4105C5H ABC transporter HV128_RS15550 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV128_RS15555 ENOG4105FDP GntR family transcriptional regulator HV128_RS15560 ENOG4105CK1 PTS System HV128_RS15565 ENOG4105CS2 ec 3.2.1.21 HV128_RS15570 ENOG4105CPC Aldo Keto reductase HV128_RS15580 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV128_RS15585 ENOG4105CW7 secretion protein, HlyD family HV128_RS15590 ENOG4105F4P )-transporter HV128_RS15595 ENOG4105KST dependent repressor HV128_RS15605 ENOG4108I6E Sulfatase HV128_RS15610 ENOG4108T1M outer membrane protein x HV128_RS15620 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HV128_RS15625 ENOG4107R0W ABC transporter HV128_RS15630 ENOG4105E5Q amino acid AbC transporter HV128_RS15635 ENOG4105CDA abc transporter atp-binding protein HV128_RS15640 ENOG4105D8X mechanosensitive ion channel HV128_RS15645 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HV128_RS15650 ENOG4105ZY9 UPF0379 protein ybiM HV128_RS15655 ENOG4105KSC Transcriptional regulator, TraR DksA family HV128_RS15660 ENOG4105VR4 UPF0379 protein ybiJ HV128_RS15665 ENOG4108MTB glycosyl transferase family HV128_RS15670 ENOG4105MX3 Fimbrial HV128_RS15675 ENOG4108VCD Chaperone HV128_RS15680 ENOG4105CW0 outer membrane usher protein HV128_RS15695 ENOG4105DVT helicase HV128_RS15700 ENOG4105C1J atp-dependent rna helicase HV128_RS15705 ENOG4107MVR Transcriptional regulator HV128_RS15710 ENOG4105D0S secretion protein (HlyD HV128_RS15715 ENOG4105CJ1 ABC, transporter HV128_RS15720 ENOG4107QWP ABC-2 type transporter HV128_RS15725 ENOG4107QWP ABC-2 type transporter HV128_RS15730 ENOG4105I9U inner membrane protein ybhQ HV128_RS15735 ENOG4105X23 Endonuclease Exonuclease phosphatase HV128_RS15740 ENOG4105DZQ phospholipase D Transphosphatidylase HV128_RS15745 ENOG4107UXM Membrane HV128_RS15750 ENOG4105HFZ Membrane HV128_RS15755 ENOG4108ZAF Molybdopterin HV128_RS15760 ENOG4105M00 molybdopterin converting factor, subunit 1 HV128_RS15765 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HV128_RS15770 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV128_RS15780 ENOG4105CHW UPF0052 protein HV128_RS15800 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV128_RS15805 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV128_RS15810 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HV128_RS15815 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HV128_RS15820 ENOG4108V1U phospholipid-binding protein HV128_RS15825 ENOG4105C84 Histidine ammonia-lyase HV128_RS15830 ENOG4105CGP Urocanate hydratase HV128_RS15840 ENOG41088SP formiminoglutamate hydrolase HV128_RS15845 ENOG4105CI2 imidazolone-5-propionate hydrolase HV128_RS15850 ENOG4105NBR Pectinesterase HV128_RS15855 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HV128_RS15860 ENOG4108K4B hydrolase HV128_RS15870 ENOG4105E0C molybdate abc transporter HV128_RS15875 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HV128_RS15885 ENOG4105F4R Transcriptional regulator mode HV128_RS15890 ENOG4105DKW ABC transporter HV128_RS15895 ENOG4105CMR udp-glucose 4-epimerase HV128_RS15900 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HV128_RS15905 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HV128_RS15910 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HV128_RS15915 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HV128_RS15920 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV128_RS15925 ENOG4105JND homeobox protein HV128_RS15930 ENOG4105PGM cation diffusion facilitator family transporter HV128_RS15935 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HV128_RS15970 ENOG4105UFD tol-pal system protein YbgF HV128_RS15975 ENOG4105KCK Peptidoglycan-associated lipoprotein HV128_RS15980 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HV128_RS15985 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HV128_RS15995 ENOG4105E02 MotA TolQ exbB proton channel HV128_RS16000 ENOG4107YD3 Thioesterase HV128_RS16005 ENOG4105KJB cyd operon protein YbgE HV128_RS16015 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV128_RS16020 ENOG4105C4M (Ubiquinol oxidase) subunit I HV128_RS16025 ENOG4105C8I hydrolase, family 38 HV128_RS16030 ENOG4105DM4 PTS System HV128_RS16035 ENOG4105FDP GntR family transcriptional regulator HV128_RS16040 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HV128_RS16045 ENOG4105CMV Succinyl-CoA synthetase subunit beta HV128_RS16050 ENOG4105C7S Dehydrogenase HV128_RS16055 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HV128_RS16060 ENOG4105E33 succinate dehydrogenase HV128_RS16065 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV128_RS16070 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HV128_RS16075 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HV128_RS16080 ENOG4105BZN citrate synthase HV128_RS16085 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HV128_RS16090 ENOG4105E7W lamb ycsf family protein HV128_RS16095 ENOG4107R7A Allophanate hydrolase subunit 2 HV128_RS16100 ENOG4105P4J Allophanate hydrolase, subunit 1 HV128_RS16105 ENOG4107QNR UPF0135 protein HV128_RS16110 ENOG4105CVP deoxyribo-dipyrimidine photolyase HV128_RS16115 ENOG4105XIQ Protein of unknown function (DUF2517) HV128_RS16125 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HV128_RS16130 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HV128_RS16135 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HV128_RS16140 ENOG4105C08 Histidine kinase HV128_RS16145 ENOG4105EEX Two component transcriptional regulator (Winged helix family HV128_RS16155 ENOG4105CXN decarboxylase HV128_RS16160 ENOG4105D5Q Arginine ornithine antiporter HV128_RS16165 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HV128_RS16170 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HV128_RS16175 ENOG4105EV9 Alpha Beta Hydrolase HV128_RS16180 ENOG4105NNH LexA regulated protein HV128_RS16185 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HV128_RS16195 ENOG41090R7 Ferric uptake HV128_RS16200 ENOG4105GX6 (LipO)protein HV128_RS16215 ENOG4105CI1 PTS System HV128_RS16225 ENOG4105CE4 GlcNAc 6-P deacetylase HV128_RS16230 ENOG4105E2R ROK family HV128_RS16235 ENOG4105D4U had-superfamily hydrolase, subfamily iia HV128_RS16240 ENOG4105CAQ asparagine synthetase HV128_RS16280 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV128_RS16285 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HV128_RS16290 ENOG4105C9A Phoh family HV128_RS16295 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HV128_RS16300 ENOG4108JU5 Magnesium and cobalt efflux protein HV128_RS16305 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HV128_RS16310 ENOG4107RP9 extracellular solute-binding protein, family 3 HV128_RS16315 ENOG4105EAD ABC transporter HV128_RS16320 ENOG4105DRP amino acid AbC transporter HV128_RS16325 ENOG4105CDA abc transporter atp-binding protein HV128_RS16330 ENOG4105DU0 nucleoside hydrolase HV128_RS16335 ENOG4107PAI alpha helical protein HV128_RS16340 ENOG4105C8T Leucyl-tRNA synthetase HV128_RS16350 ENOG4105DJF DNA polymerase III, delta' subunit HV128_RS16360 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HV128_RS16365 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HV128_RS16370 ENOG4105CJN penicillin-binding protein HV128_RS16375 ENOG4105CNI cell division protein FtsW HV128_RS16380 ENOG4105K6T rare lipoprotein A HV128_RS16385 ENOG4105DZ1 carboxypeptidase HV128_RS16390 ENOG4108Z43 UPF0250 protein HV128_RS16395 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HV128_RS16400 ENOG41064T2 transcriptional regulator, lysR family HV128_RS16405 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HV128_RS16410 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HV128_RS16430 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HV128_RS16440 ENOG4105CEE C4-dicarboxylate transporter HV128_RS16445 ENOG4105KTS ribonuclease HV128_RS16450 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HV128_RS16455 ENOG410863U PTS System HV128_RS16460 ENOG4105DC7 peptidase M24 HV128_RS16465 ENOG4105CN9 Peptidase m42 family protein HV128_RS16470 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV128_RS16475 ENOG4108CIP transcriptional regulator HV128_RS16485 ENOG4105NXH GreA GreB family elongation factor HV128_RS16490 ENOG4105E2A Dehydrogenase HV128_RS16495 ENOG4108U51 Universal stress protein HV128_RS16505 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV128_RS16510 ENOG4107QY8 reductase HV128_RS16520 ENOG4108JU3 Alkyl hydroperoxide reductase HV128_RS16525 ENOG4105D3R alkyl hydroperoxide reductase HV128_RS16530 ENOG4105DQS Transcriptional regulator HV128_RS16535 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HV128_RS16540 ENOG4105GTN ParB Domain Protein Nuclease HV128_RS16545 ENOG4105CHM Aminotransferase HV128_RS16550 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HV128_RS16555 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HV128_RS16560 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HV128_RS16565 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HV128_RS16570 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HV128_RS16585 ENOG4105CNN ABC, transporter HV128_RS16590 ENOG4105C2J ABC transporter HV128_RS16595 ENOG4107SCQ Iron-containing alcohol dehydrogenase HV128_RS16600 ENOG4105CHR reductase HV128_RS16615 ENOG4105VCD cytoplasmic protein HV128_RS16620 ENOG4105D22 carbon starvation protein HV128_RS16625 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HV128_RS16630 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HV128_RS16635 ENOG4105WQI isochorismatase HV128_RS16640 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HV128_RS16645 ENOG4105E4F Isochorismate synthase HV128_RS16650 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HV128_RS16655 ENOG4105E8G Major facilitator Superfamily HV128_RS16660 ENOG4105DQ5 transport system permease protein HV128_RS16665 ENOG4105TVJ transport system, permease HV128_RS16670 ENOG4105E0A ABC, transporter HV128_RS16675 ENOG4105C0W non-ribosomal peptide synthetase HV128_RS16680 ENOG41085A6 mbth domain-containing protein HV128_RS16685 ENOG4105E93 esterase HV128_RS16690 ENOG4107RNH Outer membrane receptor FepA HV128_RS16695 ENOG4108TSE Transferase HV128_RS16700 ENOG4105CC5 ABC transporter HV128_RS16705 ENOG4105CC5 ABC transporter HV128_RS16710 ENOG4105DIK (ABC) transporter HV128_RS16725 ENOG4105C94 Transporter HV128_RS16755 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV128_RS16760 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV128_RS16765 ENOG4105C3U ABC transporter HV128_RS16770 ENOG4108JQ7 (ABC) transporter HV128_RS16780 ENOG4105CHR reductase HV128_RS16785 ENOG4105C7K acetolactate synthase HV128_RS16825 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HV128_RS16835 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV128_RS16845 ENOG4105WQ6 Membrane HV128_RS16855 ENOG4105E0K tonB-dependent siderophore receptor HV128_RS16860 ENOG4105HFT AraC family transcriptional regulator HV128_RS16870 ENOG41067SE Tetr family transcriptional regulator HV128_RS16875 ENOG4105MSB protein, conserved in bacteria HV128_RS16880 ENOG4108RCM Nitroreductase HV128_RS16905 ENOG4105CUY Mechanosensitive ion channel HV128_RS16925 ENOG4105EAA nucleoside HV128_RS16930 ENOG4105C85 amino acid HV128_RS16945 ENOG4105TDT uncharacterized protein yahO HV128_RS16950 ENOG4105KT5 UmuD protein HV128_RS16955 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HV128_RS16960 ENOG4105CKK Glycosyl transferase, family 2 HV128_RS17070 ENOG4108N0N Phage Terminase Large Subunit HV128_RS17075 ENOG41061CV Terminase small subunit HV128_RS17085 ENOG4106050 phage regulatory protein, rha family HV128_RS17090 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HV128_RS17115 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HV128_RS17120 ENOG4105RWQ Protein of unknown function (DUF1364) HV128_RS17125 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HV128_RS17130 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HV128_RS17155 ENOG4105CDU Replicative dna helicase HV128_RS17225 ENOG4108PNI recT protein HV128_RS17245 ENOG4105DFE Dna adenine methylase HV128_RS17300 ENOG4108Q9V regulatoR HV128_RS17305 ENOG4108ZI2 Fimbrial protein HV128_RS17310 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HV128_RS17315 ENOG4105CW0 outer membrane usher protein HV128_RS17320 ENOG4108AF8 Chaperone HV128_RS17325 ENOG4105NJT Fimbrial protein HV128_RS17330 ENOG4108WDE Fimbrial protein HV128_RS17335 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HV128_RS17340 ENOG4105WQ3 Rna-binding protein HV128_RS17345 ENOG4105CI1 PTS System HV128_RS17350 ENOG4107P2S Transcriptional regulator HV128_RS17360 ENOG4105C8N cysteinyl-tRNA synthetase HV128_RS17365 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV128_RS17370 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) HV128_RS17375 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HV128_RS17380 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HV128_RS17390 ENOG4105FCK Membrane HV128_RS17395 ENOG4105CV6 ABC transporter, permease HV128_RS17400 ENOG4108I0Y (ABC) transporter HV128_RS17405 ENOG4108UJV acyl-CoA thioesterase i HV128_RS17410 ENOG4105E1F short-chain dehydrogenase reductase HV128_RS17415 ENOG4107QR8 Thioredoxin HV128_RS17420 ENOG4105C4B ABC transporter, permease HV128_RS17425 ENOG41083J0 (ABC) transporter HV128_RS17435 ENOG4107QX8 SPFH domain, Band 7 family protein HV128_RS17440 ENOG4105G5H Membrane HV128_RS17445 ENOG4108Z6Z Transcriptional regulator HV128_RS17450 ENOG4105C59 p-type ATPase HV128_RS17455 ENOG4105MBR gumn family HV128_RS17460 ENOG4108Z66 YbaK ebsC protein HV128_RS17465 ENOG4105CGH 5'-nucleotidase HV128_RS17470 ENOG4105EU0 Major facilitator Superfamily HV128_RS17475 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV128_RS17480 ENOG4107RE1 Inosine-guanosine kinase HV128_RS17485 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HV128_RS17490 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HV128_RS17495 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HV128_RS17500 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HV128_RS17505 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HV128_RS17510 ENOG4107QMP dna polymerase iii subunits gamma and tau HV128_RS17515 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HV128_RS17520 ENOG4105WD1 Membrane HV128_RS17525 ENOG4108URS primosomal replication protein n'' HV128_RS17530 ENOG4106428 Protein of unknown function (DUF2496) HV128_RS17535 ENOG4105EGS Mechanosensitive ion channel HV128_RS17540 ENOG4107XI7 Tetr family transcriptional regulator HV128_RS17545 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV128_RS17550 ENOG4105BZS acriflavin resistance protein HV128_RS17555 ENOG4108UKR Biofilm formation regulator YbaJ HV128_RS17565 ENOG4108UW5 maltose o-acetyltransferase HV128_RS17570 ENOG4105GSJ Inner membrane protein ylaC HV128_RS17585 ENOG4105YK5 50S ribosomal protein L36 HV128_RS17590 ENOG4105NRA 50s ribosomal protein l31 type b HV128_RS17595 ENOG41066DG (EAL) domain protein HV128_RS17605 ENOG41061MD high-affinity nickel-transporter HV128_RS17615 ENOG4105ETE Transcriptional regulator (LacI family HV128_RS17620 ENOG4108VW9 Membrane HV128_RS17625 ENOG4107U9B transcriptional regulator HV128_RS17645 ENOG41080UX Methyltransferase HV128_RS17650 ENOG4108MNP Glycoprotein polysaccharide metabolism HV128_RS17655 ENOG4105C29 acyl-CoA thioesterase HV128_RS17660 ENOG4105BZU Histidine kinase HV128_RS17665 ENOG4108YZA Nitrogen regulatory protein pii HV128_RS17670 ENOG4105BZ1 (ABC) transporter HV128_RS17675 ENOG4105BZ1 (ABC) transporter HV128_RS17680 ENOG4108XM1 transcriptional regulator AsnC family HV128_RS17690 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HV128_RS17695 ENOG4108NFA extracellular solute-binding protein HV128_RS17700 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HV128_RS17710 ENOG4105VUH addiction module killer protein HV128_RS17715 ENOG4108TGP Thioesterase superfamily protein HV128_RS17720 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HV128_RS17725 ENOG4105EIN peptidylprolyl cis-trans isomerase HV128_RS17730 ENOG4105K70 DNA-binding protein HV128_RS17735 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HV128_RS17750 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HV128_RS17755 ENOG4105M85 Bola protein HV128_RS17760 ENOG4105IEY (LipO)protein HV128_RS17765 ENOG4105EYM Major Facilitator superfamily HV128_RS17770 ENOG4105E2S oxidase) subunit II HV128_RS17775 ENOG4105BZ9 Cytochrome C oxidase, subunit I HV128_RS17780 ENOG4105CCU oxidase (Subunit III) HV128_RS17785 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HV128_RS17790 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HV128_RS17800 ENOG4105CMG Carbohydrate kinase HV128_RS17805 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HV128_RS17810 ENOG4105C2J ABC transporter HV128_RS17815 ENOG4105CNN ABC, transporter HV128_RS17825 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV128_RS17835 ENOG4107W7X Aldolase HV128_RS17840 ENOG4107RDB Major Facilitator HV128_RS17850 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HV128_RS17855 ENOG4107S0N DJ-1 family HV128_RS17865 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HV128_RS17870 ENOG4105CTB Polyprenyl synthetase HV128_RS17875 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HV128_RS17880 ENOG4105CPC Aldo Keto reductase HV128_RS17885 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HV128_RS17890 ENOG4107YIM Involved in the transcription termination process (By similarity) HV128_RS17895 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HV128_RS17900 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HV128_RS17905 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HV128_RS17910 ENOG4108KIC (LipO)protein HV128_RS17915 ENOG4105DRB nucleoside-specific channel-forming protein HV128_RS17930 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV128_RS17935 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV128_RS17940 ENOG4105VIE preprotein translocase, subunit YajC HV128_RS17945 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HV128_RS17955 ENOG4108ZYK Acyl carrier protein phosphodiesterase HV128_RS17960 ENOG4105D3R alkyl hydroperoxide reductase HV128_RS17975 ENOG4107R28 alpha amylase, catalytic region HV128_RS17980 ENOG4105C85 amino acid HV128_RS17985 ENOG4105CWM branched-chain amino acid transport system II carrier protein HV128_RS17990 ENOG4105BZU Histidine kinase HV128_RS18000 ENOG4107RH8 nuclease SbcCD subunit D HV128_RS18005 ENOG4105EYH Exonuclease HV128_RS18010 ENOG4105DKQ ROK family HV128_RS18020 ENOG4105NBK UPF0345 protein HV128_RS18025 ENOG4105HBA AroM protein HV128_RS18030 ENOG4105SS3 HV128_RS18035 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV128_RS18040 ENOG4108UPT UPF0178 protein HV128_RS18045 ENOG4105II7 pyrroline-5-carboxylate reductase HV128_RS18050 ENOG4105BZU Histidine kinase HV128_RS18055 ENOG4105VIF phosphate starvation-inducible protein HV128_RS18060 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) HV128_RS18075 ENOG4105CPF Cell wall formation (By similarity) HV128_RS18080 ENOG4105UNH Membrane HV128_RS18085 ENOG4105FR5 inner membrane protein YaiY HV128_RS18090 ENOG4107QS8 (LipO)protein HV128_RS18095 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HV128_RS18100 ENOG4107R6D beta-lactam binding protein AmpH HV128_RS18105 ENOG4108PNB DNA-binding transcriptional regulator HV128_RS18110 ENOG4108NSE outer membrane autotransporter barrel HV128_RS18115 ENOG4105D52 delta-aminolevulinic acid dehydratase HV128_RS18125 ENOG4105E2B Taurine dioxygenase HV128_RS18130 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HV128_RS18135 ENOG4108ETV ABC transporter HV128_RS18140 ENOG4106FTQ Taurine ABC transporter, periplasmic HV128_RS18145 ENOG4107QK5 Homocysteine s-methyltransferase HV128_RS18150 ENOG4108IQI permease HV128_RS18155 ENOG4105F4G Membrane HV128_RS18170 ENOG4105BZU Histidine kinase HV128_RS18180 ENOG4105DTA methyltransferase HV128_RS18185 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HV128_RS18190 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV128_RS18195 ENOG4105ZS6 Protein of unknown function (DUF987) HV128_RS18200 ENOG4108XS9 dna repair protein HV128_RS18205 ENOG4105MFG Antirestriction protein HV128_RS18210 ENOG4106ZN7 UPF0401 protein YkfF HV128_RS18225 ENOG4108KZE transcriptional regulator HV128_RS18260 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HV128_RS18265 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HV128_RS18270 ENOG4105FCK Membrane HV128_RS18280 ENOG4105V1F Fermentation respiration switch protein HV128_RS18285 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HV128_RS18290 ENOG4105CIN aminoacyl-histidine dipeptidase HV128_RS18295 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV128_RS18305 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HV128_RS18310 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV128_RS18315 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV128_RS18320 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV128_RS18330 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HV128_RS18335 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HV128_RS18340 ENOG4105E7A Glutamine amidotransferase HV128_RS18350 ENOG4107QPN acyl-Coa dehydrogenase HV128_RS18355 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV128_RS18365 ENOG4107RZZ dna polymerase iii epsilon subunit HV128_RS18375 ENOG4105D1A Methyltransferase HV128_RS18380 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HV128_RS18385 ENOG4105E9H Lytic Murein transglycosylase HV128_RS18390 ENOG4105F2W methyltransferase HV128_RS18395 ENOG4107NA1 Endonuclease Exonuclease phosphatase HV128_RS18400 ENOG4105F27 Major Facilitator HV128_RS18405 ENOG4105HEI LysR family (Transcriptional regulator HV128_RS18410 ENOG4105CV8 reductase HV128_RS18445 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HV128_RS18450 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HV128_RS18455 ENOG4108UMI ABC transporter, permease HV128_RS18460 ENOG4105D01 (LipO)protein HV128_RS18465 ENOG4108R8X outer membrane lipoprotein HV128_RS18470 ENOG4108R96 Methyltransferase, YaeB family HV128_RS18475 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HV128_RS18480 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HV128_RS18485 ENOG4108YZN class I peptide chain release factor HV128_RS18490 ENOG4108VWS Yaeq family HV128_RS18495 ENOG4105W1I UPF0253 protein HV128_RS18500 ENOG4105M1T rho-binding antiterminator HV128_RS18505 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HV128_RS18510 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HV128_RS18515 ENOG4105CXN decarboxylase HV128_RS18520 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HV128_RS18525 ENOG4105C0B DNA polymerase III (alpha subunit) HV128_RS18530 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV128_RS18535 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV128_RS18540 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV128_RS18545 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HV128_RS18550 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV128_RS18555 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HV128_RS18560 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV128_RS18565 ENOG4105DZP Membrane-associated zinc metalloprotease HV128_RS18570 ENOG4105KNE Phosphatidate cytidylyltransferase HV128_RS18580 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HV128_RS18590 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HV128_RS18595 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HV128_RS18605 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HV128_RS18610 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HV128_RS18615 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HV128_RS18620 ENOG4108T8E UPF0325 protein HV128_RS18625 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HV128_RS18630 ENOG4105C0H protease HV128_RS18635 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HV128_RS18640 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HV128_RS18645 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HV128_RS18650 ENOG4105EN6 Membrane HV128_RS18655 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HV128_RS18660 ENOG4105CMQ Chloride channel HV128_RS18665 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HV128_RS18670 ENOG4105S6R Iron-hydroxamate transporter permease subunit HV128_RS18675 ENOG4105J76 Periplasmic binding protein HV128_RS18680 ENOG4105E0A ABC, transporter HV128_RS18685 ENOG4105E0K tonB-dependent siderophore receptor HV128_RS18690 ENOG4105BZ4 penicillin-binding protein HV128_RS18695 ENOG4105CQ7 ATP-dependent helicase HV128_RS18700 ENOG4107XID 2'-5' rna ligase HV128_RS18705 ENOG4105PW4 Sugar fermentation stimulation protein homolog HV128_RS18710 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HV128_RS18715 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HV128_RS18720 ENOG4105DJ0 Poly(A) Polymerase HV128_RS18725 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HV128_RS18730 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HV128_RS18735 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HV128_RS18740 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HV128_RS18750 ENOG4108VEV chaperone HV128_RS18755 ENOG4105CW0 outer membrane usher protein HV128_RS18760 ENOG4108XEY fimbrial-like adhesin protein HV128_RS18780 ENOG4107BJW polysaccharide deacetylase HV128_RS18785 ENOG4108YTN IIa component HV128_RS18790 ENOG4105E3A (ABC) transporter HV128_RS18795 ENOG4105DA5 (ABC) transporter HV128_RS18800 ENOG41077A9 carbonic anhydrase HV128_RS18805 ENOG4108UGV hypoxanthine phosphoribosyltransferase HV128_RS18810 ENOG4105DZG Dehydrogenase HV128_RS18815 ENOG4105E3B Multicopper oxidase HV128_RS18820 ENOG4108ZRK uncharacterized protein yacC HV128_RS18825 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HV128_RS18830 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HV128_RS18840 ENOG4107QIJ Aconitate hydratase 2 HV128_RS18845 ENOG4108NST exported protein HV128_RS18855 ENOG4107QN2 dihydrolipoyl dehydrogenase HV128_RS18860 ENOG4107QSN dihydrolipoamide acetyltransferase HV128_RS18865 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HV128_RS18870 ENOG41073TP transcriptional regulator HV128_RS18875 ENOG4105C85 amino acid HV128_RS18880 ENOG4105CT4 transporter HV128_RS18885 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HV128_RS18890 ENOG4106A72 regulatory protein AmpE HV128_RS18895 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV128_RS18900 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HV128_RS18905 ENOG4108ZUW Major pilin subunit HV128_RS18910 ENOG4107QHF type ii secretion system protein e HV128_RS18915 ENOG4105D7Q type ii secretion system HV128_RS18920 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV128_RS18925 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HV128_RS18930 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HV128_RS18935 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HV128_RS18940 ENOG4105M6F mutator MutT protein HV128_RS18945 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HV128_RS18950 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HV128_RS18955 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV128_RS18960 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HV128_RS18965 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HV128_RS18970 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HV128_RS18975 ENOG4105CPF Cell wall formation (By similarity) HV128_RS18980 ENOG4105DFU Cell wall formation (By similarity) HV128_RS18985 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HV128_RS18990 ENOG4105CNI cell division protein FtsW HV128_RS19000 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HV128_RS19005 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HV128_RS19010 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HV128_RS19015 ENOG4105CJN penicillin-binding protein HV128_RS19020 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV128_RS19030 ENOG4108V6E Cell division protein mraZ HV128_RS19035 ENOG4107B7Y DNA-binding transcriptional regulator FruR HV128_RS19040 ENOG4108ZP8 Acetolactate synthase small subunit HV128_RS19045 ENOG4105C7K acetolactate synthase HV128_RS19050 ENOG41064T2 transcriptional regulator, lysR family HV128_RS19060 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HV128_RS19065 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HV128_RS19075 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HV128_RS19080 ENOG41060TC Hok gef cell toxic protein HV128_RS19085 ENOG4105S8Q sugar efflux transporter HV128_RS19105 ENOG4106SMU thiamine transporter membrane protein HV128_RS19115 ENOG4108KF1 Membrane HV128_RS19125 ENOG4105EF1 ribulokinase HV128_RS19130 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HV128_RS19135 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV128_RS19140 ENOG4105CQ2 DNA polymerase HV128_RS19145 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HV128_RS19150 ENOG4105D3G Pseudouridine synthase HV128_RS19155 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HV128_RS19160 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HV128_RS19165 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HV128_RS19170 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HV128_RS19175 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HV128_RS19180 ENOG4105NWN ApaG protein HV128_RS19185 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HV128_RS19190 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HV128_RS19195 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV128_RS19205 ENOG4106AS2 Outer membrane autotransporter HV128_RS19210 ENOG4105M5B (LipO)protein HV128_RS19215 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HV128_RS19220 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HV128_RS19225 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HV128_RS19230 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HV128_RS19235 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HV128_RS19240 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HV128_RS19245 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HV128_RS19250 ENOG4105DTN riboflavin biosynthesis protein ribF HV128_RS19255 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HV128_RS19260 ENOG41063Z6 transcriptional regulator, lysR family HV128_RS19265 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HV128_RS19275 ENOG4105CFG Acts as a chaperone (By similarity) HV128_RS19280 ENOG4106HK8 GPR1 FUN34 yaaH family protein HV128_RS19285 ENOG4105CSH Transporter HV128_RS19290 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV128_RS19295 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV128_RS19300 ENOG4105BZG amino acid carrier protein HV128_RS19305 ENOG4105D1Q UPF0246 protein HV128_RS19310 ENOG41062C6 Protein of unknown function (DUF2502) HV128_RS19315 ENOG4105D98 threonine synthase HV128_RS19325 ENOG4105CFH Aspartokinase HV128_RS19335 ENOG4106FVC RNA methyltransferase HV128_RS19340 ENOG410759A HV128_RS19345 ENOG41065U4 response regulator HV128_RS19350 ENOG4108RH0 Crea protein HV128_RS19355 ENOG4105UEI Transcriptional Regulator AraC Family HV128_RS19360 ENOG4105CVJ phosphoglycerate mutase HV128_RS19365 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HV128_RS19370 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HV128_RS19375 ENOG4107SC1 transglycosylase HV128_RS19380 ENOG4105C5H ABC transporter HV128_RS19385 ENOG4105JQN Transcriptional regulator HV128_RS19395 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HV128_RS19400 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HV128_RS19405 ENOG4105EAC phosphoserine phosphatase HV128_RS19410 ENOG41062Z9 Membrane HV128_RS19415 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HV128_RS19425 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HV128_RS19435 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HV128_RS19445 ENOG4105G0K glycine radical enzyme YjjI family HV128_RS19450 ENOG41076CZ activating enzyme HV128_RS19455 ENOG4105EYA deoxyribonuclease HV128_RS19460 ENOG4108NRW Phospholipase, patatin family HV128_RS19470 ENOG4105K3G Periplasmic Protein HV128_RS19475 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HV128_RS19480 ENOG4105PAD Hydrolase HV128_RS19485 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HV128_RS19490 ENOG4108WPU DNA polymerase III subunit psi HV128_RS19495 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV128_RS19515 ENOG4105YBH Protein of unknown function (DUF1435) HV128_RS19520 ENOG4106TD9 Diguanylate cyclase HV128_RS19525 ENOG4108819 ferric iron reductase HV128_RS19530 ENOG4105CK1 PTS System HV128_RS19535 ENOG4108UIN ybak prolyl-trna synthetase associated region HV128_RS19540 ENOG4108T94 DNA-binding transcriptional activator BglJ HV128_RS19545 ENOG4108N8T regulatoR HV128_RS19550 ENOG4105DWK Membrane HV128_RS19555 ENOG4107XM3 UPF0442 protein HV128_RS19560 ENOG4105K56 Transcriptional regulator HV128_RS19565 ENOG4108ZHJ Organic hydroperoxide resistance protein HV128_RS19570 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HV128_RS19575 ENOG4106CVF DNA replication protein HV128_RS19580 ENOG4105RI1 glycoprotein receptor HV128_RS19585 ENOG4107RES phosphoglycerol transferase I HV128_RS19590 ENOG4105XYF acetyltransferase HV128_RS19595 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS19600 ENOG4108V8F Transcriptional regulator, MarR family HV128_RS19605 ENOG4105ERH Fumarylacetoacetate hydrolase HV128_RS19610 ENOG4105C26 Dehydrogenase HV128_RS19615 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HV128_RS19630 ENOG4105CNV Aldolase HV128_RS19645 ENOG4105EFA 4-hydroxyphenylacetate HV128_RS19650 ENOG4107UWN reductase HV128_RS19655 ENOG4105YW5 deoR family transcriptional regulator HV128_RS19660 ENOG4105D22 carbon starvation protein HV128_RS19665 ENOG4105VCD cytoplasmic protein HV128_RS19670 ENOG4105CKI cobalamin synthesis protein HV128_RS19675 ENOG4105PF3 O-Antigen polymerase HV128_RS19680 ENOG4105X1N Glycosyl transferase family 8 HV128_RS19695 ENOG4105C26 Dehydrogenase HV128_RS19710 ENOG4106BRA Membrane HV128_RS19720 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV128_RS19730 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV128_RS19745 ENOG4106DIZ Domain of unknown function (DUF1127) HV128_RS19750 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV128_RS19755 ENOG4105EZE Cupin 4 family protein HV128_RS19760 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HV128_RS19765 ENOG4108ZXC Two component transcriptional regulator, luxr family HV128_RS19770 ENOG4105BZU Histidine kinase HV128_RS19790 ENOG4105CHJ isochorismatase hydrolase HV128_RS19815 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HV128_RS19825 ENOG4105CT4 transporter HV128_RS19835 ENOG4105ETE Transcriptional regulator (LacI family HV128_RS19850 ENOG4105CVR type I restriction-modification system HV128_RS19865 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HV128_RS19870 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HV128_RS19875 ENOG4105DBV ornithine carbamoyltransferase HV128_RS19880 ENOG4107HP6 Transcriptional regulator HV128_RS19885 ENOG4105DSG hydrolase family 43 HV128_RS19890 ENOG4105CT4 transporter HV128_RS19895 ENOG4105C01 Dihydroxy-acid dehydratase HV128_RS19900 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV128_RS19905 ENOG4105XEP YhcH YjgK YiaL family protein HV128_RS19910 ENOG4105CEU Arginine dihydrolase HV128_RS19915 ENOG4105C5B carbamate kinase HV128_RS19920 ENOG4105DBV ornithine carbamoyltransferase HV128_RS19925 ENOG4105CSX c4-dicarboxylate anaerobic carrier HV128_RS19930 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HV128_RS19940 ENOG41077AM PyrBI operon attenuator HV128_RS19945 ENOG4105CXT aspartate transcarbamylase HV128_RS19950 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HV128_RS19955 ENOG4105KME endoribonuclease L-psp HV128_RS19960 ENOG4108M1A Chitin-binding protein HV128_RS19965 ENOG4105E2D ec 3.2.1.52 HV128_RS19975 ENOG4105D4X repressor HV128_RS19980 ENOG4105C5Y PTS System HV128_RS19985 ENOG4105CG3 alpha amylase, catalytic region HV128_RS19990 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HV128_RS19995 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HV128_RS20000 ENOG4105EMD TRANSCRIPTIONal HV128_RS20005 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HV128_RS20020 ENOG41069H0 dihydroorotase EC 3.5.2.3 HV128_RS20050 ENOG41074AV Hok/gef family HV128_RS20055 ENOG4108XVM Cytochrome b(562) HV128_RS20060 ENOG4105CMS peptidase U62, modulator of DNA gyrase HV128_RS20065 ENOG4105N42 UPF0307 protein HV128_RS20070 ENOG4105DFU Cell wall formation (By similarity) HV128_RS20080 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS20085 ENOG41062B0 ABC transporter, permease HV128_RS20090 ENOG4107R9N ABC transporter HV128_RS20095 ENOG4105C2J ABC transporter HV128_RS20100 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HV128_RS20105 ENOG4105F0N pyrophosphate phospho-hydrolase HV128_RS20110 ENOG4108ZHD aig2 family HV128_RS20115 ENOG4105MA0 exported protein HV128_RS20120 ENOG4105CFU surface antigen HV128_RS20125 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HV128_RS20130 ENOG4105C37 (CBS) domain HV128_RS20135 ENOG41061GZ Protein of unknown function (DUF1107) HV128_RS20140 ENOG4108UUE Transcriptional regulator HV128_RS20145 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HV128_RS20150 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HV128_RS20155 ENOG4105KVH Transcriptional regulator HV128_RS20160 ENOG4105ECR NmrA family HV128_RS20170 ENOG4105DXC membrane HV128_RS20175 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS20180 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HV128_RS20190 ENOG4108V1T peptidylprolyl cis-trans isomerase HV128_RS20195 ENOG4105FHY Opacity-associated protein A HV128_RS20200 ENOG4108IPJ Membrane HV128_RS20205 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HV128_RS20210 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HV128_RS20215 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HV128_RS20220 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HV128_RS20225 ENOG4105KIT UPF0379 protein yjfY HV128_RS20255 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HV128_RS20270 ENOG4108MXZ Esterase HV128_RS20275 ENOG4105WSB biofilm stress and motility protein A HV128_RS20280 ENOG4105S17 UPF0379 protein yjfN HV128_RS20285 ENOG4105C8Q Methyl-accepting chemotaxis HV128_RS20290 ENOG4105CSU acyl-Coa dehydrogenase HV128_RS20295 ENOG4105CSH Transporter HV128_RS20300 ENOG4106032 Glutathionylspermidine synthase HV128_RS20305 ENOG4108KXT Conserved Protein HV128_RS20310 ENOG4105Z6B inner membrane protein yjfl HV128_RS20315 ENOG4107VNS Protein of unknown function (DUF2491) HV128_RS20325 ENOG4108P9J Phage shock protein A HV128_RS20330 ENOG4105FUX Conserved Protein HV128_RS20335 ENOG4105C2N RNA methyltransferase TrmH family group 3 HV128_RS20340 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HV128_RS20345 ENOG4105KPV Transcriptional regulator HV128_RS20360 ENOG4105EPW hflc protein HV128_RS20365 ENOG4107QJR hflk protein HV128_RS20370 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HV128_RS20375 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HV128_RS20380 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HV128_RS20385 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HV128_RS20390 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV128_RS20395 ENOG4105K8N protein family UPF0079, ATPase HV128_RS20400 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HV128_RS20405 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HV128_RS20440 ENOG4105EGS Mechanosensitive ion channel HV128_RS20445 ENOG4107SC7 Inner membrane transporter yjeM HV128_RS20450 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HV128_RS20455 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV128_RS20460 ENOG4105E33 succinate dehydrogenase HV128_RS20465 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HV128_RS20475 ENOG4105ETT transcriptional Regulator, LysR family HV128_RS20480 ENOG4106FGB Beta-lactamase HV128_RS20500 ENOG4106BSU Entericidin B HV128_RS20510 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HV128_RS20515 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HV128_RS20520 ENOG4108ZVF (LipO)protein HV128_RS20525 ENOG41074DU domain protein HV128_RS20530 ENOG4108P2H Inner membrane protein YjiG HV128_RS20535 ENOG4105DYB Isoaspartyl dipeptidase HV128_RS20550 ENOG4105DVH amino acid HV128_RS20555 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HV128_RS20560 ENOG4108IJ0 Aspartate ammonia-lyase HV128_RS20565 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV128_RS20570 ENOG4105VF7 tolerance protein HV128_RS20575 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HV128_RS20580 ENOG4108SIC Transcriptional regulator HV128_RS20600 ENOG4108R5S membrane HV128_RS20625 ENOG4108Z0R Transferase HV128_RS20630 ENOG4105SG3 Protein of unknown function (DUF1488) HV128_RS20635 ENOG4105E2X shikimate dehydrogenase HV128_RS20640 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV128_RS20645 ENOG4108WI1 Dna topoisomerase HV128_RS20650 ENOG4108RPN Protein smg homolog HV128_RS20660 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HV128_RS20665 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HV128_RS20670 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HV128_RS20675 ENOG4105C1A potassium transporter peripheral membrane HV128_RS20680 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HV128_RS20685 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HV128_RS20690 ENOG4105W1Y Transcriptional regulator HV128_RS20695 ENOG4105VTS DnaJ-like, subfamily C HV128_RS20705 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV128_RS20710 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HV128_RS20715 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HV128_RS20725 ENOG41067V7 50S ribosomal protein L36 HV128_RS20730 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HV128_RS20740 ENOG4105VPB 50S ribosomal protein L30 HV128_RS20755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HV128_RS20760 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HV128_RS20765 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HV128_RS20775 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HV128_RS20780 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HV128_RS20790 ENOG41083MP 50s ribosomal protein l29 HV128_RS20795 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HV128_RS20805 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HV128_RS20845 ENOG4108UQY Iron-storage protein HV128_RS20850 ENOG4105W53 bacterioferritin-associated ferredoxin HV128_RS20855 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HV128_RS20860 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HV128_RS20875 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV128_RS20880 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV128_RS20885 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HV128_RS20890 ENOG4105WWK YheO domain protein HV128_RS20895 ENOG4108V1T peptidylprolyl cis-trans isomerase HV128_RS20900 ENOG4105VRX Protein slyX homolog HV128_RS20905 ENOG4108YZY peptidylprolyl cis-trans isomerase HV128_RS20910 ENOG4105VKU nucleicacid-binding protein HV128_RS20915 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV128_RS20920 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HV128_RS20925 ENOG4105C5H ABC transporter HV128_RS20930 ENOG4108K70 Transcriptional regulator HV128_RS20935 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV128_RS20940 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HV128_RS20945 ENOG4107TT2 Auxin Efflux Carrier HV128_RS20975 ENOG4105DNZ Alpha Beta Hydrolase HV128_RS20980 ENOG4105YP7 UPF0270 protein HV128_RS20985 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HV128_RS20990 ENOG4108UKZ OsmC family HV128_RS20995 ENOG4107RYR Transcriptional regulator, Crp Fnr family HV128_RS21000 ENOG410613R integral membrane protein, YccS YhfK family HV128_RS21005 ENOG4105C8Y Acetylornithine aminotransferase HV128_RS21010 ENOG4105DDQ anthranilate synthase HV128_RS21015 ENOG4105MZU cell filamentation protein HV128_RS21020 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV128_RS21025 ENOG4106DTQ Protein TsgA homolog HV128_RS21030 ENOG4107QZF nitrite reductase NADPH large subunit HV128_RS21035 ENOG4105WZK nitrite reductase NADPH small subunit HV128_RS21040 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HV128_RS21045 ENOG4105VYH HV128_RS21050 ENOG4105C31 Tryptophanyl-tRNA synthetase HV128_RS21060 ENOG4105DJV ribulose-phosphate 3-epimerase HV128_RS21065 ENOG4105DFE Dna adenine methylase HV128_RS21070 ENOG4105EGB membrane protein DamX HV128_RS21075 ENOG4105D49 3-dehydroquinate synthase HV128_RS21080 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV128_RS21085 ENOG4105E4G Type IV pilus HV128_RS21105 ENOG4108U1Q Pilus assembly protein HV128_RS21110 ENOG4108JQC penicillin-binding protein 1A HV128_RS21115 ENOG4107RK2 ADP-ribose diphosphatase NudE HV128_RS21120 ENOG4105DQY intracellular growth attenuator HV128_RS21125 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HV128_RS21130 ENOG4105VEJ Heat shock protein HV128_RS21135 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HV128_RS21140 ENOG4108MAJ Membrane HV128_RS21145 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HV128_RS21150 ENOG4105E0F Histidine kinase HV128_RS21160 ENOG4108RRZ Transcription elongation factor GreB HV128_RS21165 ENOG4105BZM domain protein HV128_RS21170 ENOG4105XFK Ferrous iron transport protein A HV128_RS21180 ENOG41060N5 May function as a transcriptional regulator that controls feoABC expression (By similarity) HV128_RS21185 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HV128_RS21190 ENOG4105MJ2 Competence protein HV128_RS21195 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HV128_RS21200 ENOG4105C6Z Gluconate HV128_RS21205 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HV128_RS21210 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV128_RS21215 ENOG41061ZR Transcriptional regulator HV128_RS21220 ENOG4105E98 transcriptional regulator DeoR family HV128_RS21225 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HV128_RS21230 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HV128_RS21235 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HV128_RS21240 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV128_RS21245 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HV128_RS21250 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HV128_RS21255 ENOG4108ESZ Glycogen debranching enzyme HV128_RS21260 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV128_RS21265 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV128_RS21270 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HV128_RS21280 ENOG4105C6Z Gluconate HV128_RS21285 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV128_RS21290 ENOG4105DIQ Transcriptional regulator HV128_RS21295 ENOG4105C2I pirin domain protein HV128_RS21300 ENOG4105D9R oxidoreductase HV128_RS21305 ENOG4105WCN acetyltransferase HV128_RS21310 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HV128_RS21315 ENOG4105WC8 Conserved Protein HV128_RS21320 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HV128_RS21335 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HV128_RS21340 ENOG4105BZ7 extracellular solute-binding protein family 1 HV128_RS21345 ENOG4108IV0 ABC, transporter HV128_RS21350 ENOG4105C0Z ABC transporter HV128_RS21355 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV128_RS21360 ENOG4105C32 Amino acid ABC transporter (Permease) HV128_RS21365 ENOG4105CP9 extracellular ligand-binding receptor HV128_RS21370 ENOG4105U59 -acetyltransferase HV128_RS21375 ENOG4105CP9 extracellular ligand-binding receptor HV128_RS21380 ENOG4108JPW Aminotransferase HV128_RS21385 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV128_RS21390 ENOG4105CRP Part of the ABC transporter FtsEX involved in HV128_RS21395 ENOG4105CAK Cell division ATP-binding protein ftsE HV128_RS21400 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HV128_RS21405 ENOG4106H78 methyltransferase HV128_RS21410 ENOG4105MG3 Membrane HV128_RS21420 ENOG4107FS9 Membrane HV128_RS21425 ENOG4105C59 p-type ATPase HV128_RS21430 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV128_RS21440 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV128_RS21445 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HV128_RS21450 ENOG4105EX9 Membrane HV128_RS21455 ENOG4108W1V Lipoprotein HV128_RS21460 ENOG4105DSF transport protein HV128_RS21500 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HV128_RS21525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV128_RS21535 ENOG4105C2D reductase HV128_RS21540 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV128_RS21545 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HV128_RS21550 ENOG4105PY6 Phenolic acid decarboxylase HV128_RS21555 ENOG4105ETT transcriptional Regulator, LysR family HV128_RS21560 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HV128_RS21580 ENOG4107258 Transcriptional regulator HV128_RS21585 ENOG4105JSC dimethylmenaquinone methyltransferase HV128_RS21600 ENOG4105GR3 Histidine kinase HV128_RS21605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV128_RS21610 ENOG4108PG2 copper resistance HV128_RS21615 ENOG4105JDN Copper resistance protein HV128_RS21620 ENOG4105VR0 copper resistance HV128_RS21625 ENOG4105E3B Multicopper oxidase HV128_RS21635 ENOG4105DR5 peptidase HV128_RS21665 ENOG410624V efflux system protein HV128_RS21740 ENOG4105CBX hi0933 family HV128_RS21745 ENOG4105CJ3 phosphate transporter HV128_RS21750 ENOG4108V6B universal stress protein B HV128_RS21760 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HV128_RS21765 ENOG4105DGW oligopeptidase A HV128_RS21770 ENOG4105D6S protein involved in catabolism of external DNA HV128_RS21775 ENOG4105DC8 reductase HV128_RS21805 ENOG4106S2D Transcriptional regulator HV128_RS21810 ENOG4105CHR reductase HV128_RS21815 ENOG4105CBN LysR family transcriptional regulator HV128_RS21820 ENOG4107H3J ribonuclease HV128_RS21825 ENOG4105CSH Transporter HV128_RS21830 ENOG41066T0 asmA family HV128_RS21835 ENOG4105CMB EAL domain-containing protein HV128_RS21845 ENOG4105CS0 peptidase HV128_RS21850 ENOG4105CK2 sodium dicarboxylate symporter HV128_RS21855 ENOG4105BZU Histidine kinase HV128_RS21860 ENOG4105EJG cellulose synthase HV128_RS21865 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HV128_RS21870 ENOG4107EEX Cellulose synthase regulator protein HV128_RS21875 ENOG4107QZ7 Cellulose synthase catalytic subunit HV128_RS21880 ENOG4105UTS cellulose synthase operon protein YhjQ HV128_RS21885 ENOG410661M cytoplasmic protein HV128_RS21890 ENOG4105U74 cellulose biosynthesis protein BcsE HV128_RS21895 ENOG410675P Celllulose biosynthesis operon protein BcsF YhjT HV128_RS21900 ENOG4105D1V cellulose synthase operon protein YhjU HV128_RS21905 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HV128_RS21910 ENOG4105D4A Cell wall formation (By similarity) HV128_RS21940 ENOG4108RR8 protoporphyrinogen oxidase HV128_RS21945 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV128_RS21950 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HV128_RS21955 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HV128_RS21960 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV128_RS21965 ENOG4105CHU acetyl-coa acetyltransferase HV128_RS21970 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HV128_RS21975 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit HV128_RS21985 ENOG4105MEV Acyl-transferase HV128_RS21990 ENOG4105CMG Carbohydrate kinase HV128_RS21995 ENOG4105C93 Xylose Isomerase HV128_RS22000 ENOG4105DFW ABC transporter HV128_RS22005 ENOG4105C2J ABC transporter HV128_RS22010 ENOG4108HWW ABC transporter HV128_RS22015 ENOG4105T16 Transcriptional regulator (AraC family) HV128_RS22020 ENOG4108UR8 BAX protein HV128_RS22025 ENOG4107T9C Alpha amylase catalytic region HV128_RS22030 ENOG4105JKW Valine--pyruvate aminotransferase HV128_RS22035 ENOG4108XIB electron transport protein ysaA HV128_RS22040 ENOG4105J4Q Transcriptional regulator HV128_RS22045 ENOG4105DG4 malate L-lactate dehydrogenase HV128_RS22050 ENOG4108R66 Conserved Protein HV128_RS22055 ENOG4108M5W HV128_RS22060 ENOG4105DJB Major Facilitator Superfamily HV128_RS22065 ENOG4105CMG Carbohydrate kinase HV128_RS22070 ENOG4105H6Q decarboxylase HV128_RS22075 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HV128_RS22080 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV128_RS22085 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HV128_RS22090 ENOG4105CT4 transporter HV128_RS22100 ENOG4105C26 Dehydrogenase HV128_RS22105 ENOG41066F8 ROK family HV128_RS22110 ENOG4105EM7 Selenocysteine-specific translation elongation factor HV128_RS22120 ENOG4108U78 Glutathione S-transferase HV128_RS22125 ENOG4105CTS PTS system mannitol-specific HV128_RS22135 ENOG4105E61 Mannitol repressor protein HV128_RS22140 ENOG4108YYI Protein of unknown function (DUF2810) HV128_RS22150 ENOG4105CW0 outer membrane usher protein HV128_RS22155 ENOG4108VCD Chaperone HV128_RS22160 ENOG4108S54 Fimbrial protein HV128_RS22165 ENOG4105DAA L-lactate HV128_RS22170 ENOG41073TP transcriptional regulator HV128_RS22175 ENOG4105DMF Dehydrogenase HV128_RS22180 ENOG4105D2S major facilitator superfamily HV128_RS22185 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HV128_RS22195 ENOG4105EMY transcriptional regulator HV128_RS22200 ENOG4105C7B Threonine dehydratase HV128_RS22210 ENOG4105CM2 brancheD-chain amino acid aminotransferase HV128_RS22215 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HV128_RS22230 ENOG4105C0P Mg chelatase subunit ChlI HV128_RS22235 ENOG4108WFC UPF0438 protein yifE HV128_RS22285 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HV128_RS22290 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HV128_RS22295 ENOG4108Y73 Membrane HV128_RS22300 ENOG4105EJ2 Transcriptional regulator HV128_RS22310 ENOG4105C5Q Transcriptional regulator HV128_RS22315 ENOG4105CH7 arginosuccinase HV128_RS22320 ENOG4105CAS nag kinase HV128_RS22325 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HV128_RS22330 ENOG4105CWC Acetylornithine deacetylase HV128_RS22335 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HV128_RS22340 ENOG4105DCT glycerol dehydrogenase HV128_RS22345 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HV128_RS22350 ENOG4105SYT Methylenetetrahydrofolate reductase HV128_RS22355 ENOG4105CFH Aspartokinase HV128_RS22360 ENOG4105C28 cystathionine HV128_RS22365 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HV128_RS22370 ENOG4108QGT oligogalacturonate-specific porin HV128_RS22375 ENOG4105VFB Binds the 23S rRNA (By similarity) HV128_RS22380 ENOG4105C25 Primosomal protein n' HV128_RS22385 ENOG4105ETE Transcriptional regulator (LacI family HV128_RS22390 ENOG41063M6 Cell Division Protein HV128_RS22395 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HV128_RS22405 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HV128_RS22410 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HV128_RS22415 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HV128_RS22420 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV128_RS22430 ENOG4105CBT Fructose-1,6-bisphosphatase HV128_RS22435 ENOG4105DP0 ferredoxin-NADP reductase HV128_RS22440 ENOG4108VTS Membrane HV128_RS22445 ENOG4105EBK exported protein HV128_RS22450 ENOG4105CP7 Triose-phosphate isomerase HV128_RS22460 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HV128_RS22465 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HV128_RS22470 ENOG4105CTQ phosphohexokinase HV128_RS22475 ENOG41076HS cation diffusion facilitator family transporter HV128_RS22480 ENOG4105FMW periplasmic HV128_RS22485 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV128_RS22490 ENOG4105E0F Histidine kinase HV128_RS22495 ENOG4108RPX mosc domain containing protein HV128_RS22500 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV128_RS22505 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HV128_RS22510 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HV128_RS22515 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HV128_RS22520 ENOG4105DET Rhamnulokinase HV128_RS22525 ENOG4105DKG l-rhamnose isomerase HV128_RS22530 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HV128_RS22535 ENOG4105D4B ABC, transporter HV128_RS22540 ENOG4105C2J ABC transporter HV128_RS22545 ENOG4105CNN ABC, transporter HV128_RS22550 ENOG4105F5R ABC transporter HV128_RS22555 ENOG4105C0A alcohol dehydrogenase HV128_RS22560 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HV128_RS22565 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV128_RS22585 ENOG4108UMN azlc family HV128_RS22600 ENOG4105E6S usher protein( HV128_RS22605 ENOG4108S1B Periplasmic chaperone protein HV128_RS22630 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV128_RS22635 ENOG4108MG3 formate dehydrogenase HV128_RS22640 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HV128_RS22650 ENOG41068KX affects formate dehydrogenase-N HV128_RS22660 ENOG4105SUU thioesterase domain HV128_RS22665 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HV128_RS22670 ENOG4107S2Z UPF0761 membrane protein HV128_RS22675 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HV128_RS22680 ENOG4105E98 transcriptional regulator DeoR family HV128_RS22685 ENOG4108MGF sugar kinase HV128_RS22690 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV128_RS22695 ENOG4105D2M Aldolase HV128_RS22700 ENOG4107QKS N-acylglucosamine 2-epimerase HV128_RS22705 ENOG4105CJQ hydrolase, family 31 HV128_RS22710 ENOG4105CT4 transporter HV128_RS22720 ENOG4105EQR Transposase IS116 IS110 IS902 HV128_RS22725 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HV128_RS22730 ENOG4105CI3 gtp-binding protein typa HV128_RS22735 ENOG4105C5F glutamine synthetase HV128_RS22740 ENOG4105CUX Signal transduction histidine kinase HV128_RS22745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV128_RS22750 ENOG4106FIY HV128_RS22755 ENOG4105D4P Coproporphyrinogen iii oxidase HV128_RS22760 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HV128_RS22765 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HV128_RS22770 ENOG4105C2M dna polymerase I HV128_RS22775 ENOG4106HNH Acyl-transferase HV128_RS22780 ENOG4108Z33 Thiol disulfide Interchange Protein HV128_RS22785 ENOG4105E27 serine threonine protein kinase HV128_RS22790 ENOG4105PC1 Conserved Protein HV128_RS22795 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HV128_RS22800 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HV128_RS22825 ENOG4107EJG GntR family transcriptional regulator HV128_RS22830 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV128_RS22835 ENOG4105ETE Transcriptional regulator (LacI family HV128_RS22840 ENOG4108RVA ribokinase HV128_RS22845 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV128_RS22850 ENOG4105CNN ABC, transporter HV128_RS22855 ENOG4105C2J ABC transporter HV128_RS22860 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HV128_RS22865 ENOG4105DFH Transport of potassium into the cell (By similarity) HV128_RS22875 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HV128_RS22880 ENOG4105CU9 asparagine synthetase A HV128_RS22885 ENOG4108VVK transcriptional Regulator, AsnC HV128_RS22890 ENOG4105QTB Flavodoxin HV128_RS22895 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HV128_RS22900 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HV128_RS22905 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HV128_RS22910 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HV128_RS22920 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HV128_RS22925 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HV128_RS22930 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HV128_RS22940 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HV128_RS22945 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HV128_RS22950 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HV128_RS22955 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HV128_RS22960 ENOG4106EAR Fimbrial protein HV128_RS22965 ENOG4108VCD Chaperone HV128_RS22970 ENOG4105CW0 outer membrane usher protein HV128_RS22975 ENOG4105I74 Fimbrial protein HV128_RS22980 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HV128_RS22985 ENOG4105C8U phosphate abc transporter HV128_RS22990 ENOG4105E2Z phosphate ABC transporter (Permease HV128_RS22995 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HV128_RS23005 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HV128_RS23010 ENOG4105C7N Xanthine uracil vitamin C permease HV128_RS23015 ENOG4108YYH Nadph-dependent fmn reductase HV128_RS23020 ENOG4105E8Q phosphopantetheinyl transferase HV128_RS23025 ENOG4105G2Y Transcriptional regulator HV128_RS23030 ENOG4105CNH Multidrug resistance protein MdtL HV128_RS23035 ENOG41080E2 ribosomal-protein-alanine acetyltransferase HV128_RS23040 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HV128_RS23045 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HV128_RS23055 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HV128_RS23060 ENOG4105VG0 50S ribosomal protein l34 HV128_RS23090 ENOG4105D0M Protease HtpX homolog HV128_RS23150 ENOG4105EQR Transposase IS116 IS110 IS902 HV128_RS23165 ENOG4105CHH sulfate transporter HV128_RS23180 ENOG4105EQR Transposase IS116 IS110 IS902 HV128_RS23230 ENOG4105EKQ RNA-directed DNA polymerase HV128_RS23295 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HV128_RS23315 ENOG4105VN1 Heat shock protein HV128_RS23320 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV128_RS23375 ENOG4105M5B (LipO)protein HV128_RS23415 ENOG41081XE plasmid maintenance system antidote protein, xre family HV128_RS23420 ENOG41080ET plasmid maintenance system killer protein