locus-tag	class	description
HV128_RS00010	COG0592	DNA-directed DNA polymerase activity
HV128_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HV128_RS00025	COG0583	DNA-binding transcription factor activity
HV128_RS00030	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS00030	COG0604	alcohol dehydrogenase
HV128_RS00030	COG3321	synthase
HV128_RS00035	COG0561	phosphatase activity
HV128_RS00040	COG2186	Transcriptional regulator
HV128_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HV128_RS00050	COG0800	Aldolase
HV128_RS00055	COG4948	Mandelate Racemase Muconate Lactonizing
HV128_RS00060	COG2271	Major facilitator Superfamily
HV128_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
HV128_RS00070	COG5645	(Lipo)protein
HV128_RS00080	COG0071	Belongs to the small heat shock protein (HSP20) family
HV128_RS00085	COG2985	domain, Protein
HV128_RS00090	COG2188	Transcriptional regulator
HV128_RS00105	COG2149	membrane
HV128_RS00125	COG2814	Major facilitator Superfamily
HV128_RS00150	COG5499	transcription regulator containing HTH domain
HV128_RS00160	COG0028	Belongs to the TPP enzyme family
HV128_RS00165	COG0440	acetolactate synthase activity
HV128_RS00170	COG2197	response regulator
HV128_RS00195	COG0583	DNA-binding transcription factor activity
HV128_RS00215	COG0697	spore germination
HV128_RS00220	COG4580	involved in the transport of maltose and maltodextrins
HV128_RS00225	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV128_RS00245	COG2003	Belongs to the UPF0758 family
HV128_RS00315	COG3121	Chaperone
HV128_RS00345	COG2351	hydroxyisourate hydrolase activity
HV128_RS00350	COG3272	Protein of unknown function (DUF1722)
HV128_RS00365	COG4115	mRNA cleavage
HV128_RS00370	COG2161	toxin-antitoxin pair type II binding
HV128_RS00385	COG2274	protein secretion by the type I secretion system
HV128_RS00410	COG3188	usher protein
HV128_RS00440	COG3121	Chaperone
HV128_RS00445	COG3188	usher protein
HV128_RS00470	COG1464	Belongs to the NlpA lipoprotein family
HV128_RS00480	COG1487	ribonuclease activity
HV128_RS00495	COG1309	transcriptional regulator
HV128_RS00500	COG0454	-acetyltransferase
HV128_RS00510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV128_RS00515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV128_RS00525	COG2814	Major facilitator Superfamily
HV128_RS00535	COG1609	Transcriptional regulator
HV128_RS00545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV128_RS00545	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV128_RS00570	COG2211	Major facilitator Superfamily
HV128_RS00575	COG1501	Belongs to the glycosyl hydrolase 31 family
HV128_RS00580	COG2982	Protein involved in outer membrane biogenesis
HV128_RS00585	COG2233	PERMEase
HV128_RS00590	COG0786	glutamate:sodium symporter activity
HV128_RS00595	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV128_RS00600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV128_RS00605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV128_RS00620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HV128_RS00640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV128_RS00645	COG1596	polysaccharide export
HV128_RS00650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HV128_RS00655	COG3206	protein involved in exopolysaccharide biosynthesis
HV128_RS00655	COG0489	protein tyrosine kinase activity
HV128_RS00660	COG2860	membrane
HV128_RS00665	COG1561	YicC-like family, N-terminal region
HV128_RS00675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HV128_RS00685	COG0756	dUTP diphosphatase activity
HV128_RS00690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV128_RS00695	COG2003	Belongs to the UPF0758 family
HV128_RS00700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HV128_RS00705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV128_RS00710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HV128_RS00715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HV128_RS00725	COG1519	Transferase
HV128_RS00730	COG1216	Glycosyl transferase, family 2
HV128_RS00735	COG0438	transferase activity, transferring glycosyl groups
HV128_RS00745	COG0859	PFAM glycosyl transferase family 9
HV128_RS00755	COG1216	Glycosyl transferase, family 2
HV128_RS00765	COG0859	PFAM glycosyl transferase family 9
HV128_RS00770	COG0859	PFAM glycosyl transferase family 9
HV128_RS00785	COG1063	alcohol dehydrogenase
HV128_RS00795	COG0438	transferase activity, transferring glycosyl groups
HV128_RS00800	COG0463	Glycosyl transferase, family 2
HV128_RS00805	COG2861	carbohydrate metabolic process
HV128_RS00810	COG4942	peptidase
HV128_RS00815	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HV128_RS00820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV128_RS00825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV128_RS00830	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HV128_RS00835	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HV128_RS00845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV128_RS00855	COG0248	Ppx GppA phosphatase
HV128_RS00865	COG3118	belongs to the thioredoxin family
HV128_RS00870	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV128_RS00875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV128_RS00885	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HV128_RS00890	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV128_RS00895	COG0456	acetyltransferase
HV128_RS00900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV128_RS00905	COG2244	polysaccharide biosynthetic process
HV128_RS00920	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HV128_RS00955	COG3071	HemY protein
HV128_RS00960	COG2959	enzyme of heme biosynthesis
HV128_RS00970	COG0181	hydroxymethylbilane synthase activity
HV128_RS00985	COG5567	small periplasmic lipoprotein
HV128_RS01005	COG1011	Hydrolase
HV128_RS01010	COG0210	DNA helicase
HV128_RS01030	COG2826	transposase and inactivated derivatives, IS30 family
HV128_RS01035	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HV128_RS01045	COG1280	lysine exporter protein (LysE YggA)
HV128_RS01050	COG1280	lysine exporter protein (LysE YggA)
HV128_RS01055	COG2267	carboxylic ester hydrolase activity
HV128_RS01060	COG0561	phosphatase activity
HV128_RS01065	COG0697	spore germination
HV128_RS01070	COG0583	DNA-binding transcription factor activity
HV128_RS01080	COG0412	Dienelactone hydrolase
HV128_RS01090	COG1322	Protein conserved in bacteria
HV128_RS01095	COG2226	methyltransferase
HV128_RS01100	COG3165	ubiquinone biosynthetic process from chorismate
HV128_RS01105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HV128_RS01120	COG0805	protein transport
HV128_RS01125	COG0084	hydrolase, TatD family'
HV128_RS01135	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV128_RS01150	COG2944	sequence-specific DNA binding
HV128_RS01160	COG1278	Cold shock
HV128_RS01165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV128_RS01175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV128_RS01185	COG1609	Transcriptional regulator
HV128_RS01190	COG2885	chlorophyll binding
HV128_RS01195	COG0243	molybdopterin cofactor binding
HV128_RS01200	COG0456	acetyltransferase
HV128_RS01205	COG2818	Glycosylase
HV128_RS01210	COG5571	outer membrane autotransporter
HV128_RS01215	COG2223	nitrite transmembrane transporter activity
HV128_RS01255	COG0747	negative chemotaxis
HV128_RS01260	COG0601	transmembrane transport
HV128_RS01265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV128_RS01270	COG0444	Belongs to the ABC transporter superfamily
HV128_RS01275	COG4608	Belongs to the ABC transporter superfamily
HV128_RS01280	COG1072	(Pantothenic acid kinase))
HV128_RS01315	COG0250	Participates in transcription elongation, termination and antitermination
HV128_RS01360	COG3706	GGDEF domain
HV128_RS01370	COG2022	thiamine diphosphate biosynthetic process
HV128_RS01375	COG2104	thiamine diphosphate biosynthetic process
HV128_RS01380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV128_RS01395	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HV128_RS01405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HV128_RS01410	COG1515	deoxyribonuclease V activity
HV128_RS01415	COG3068	Protein conserved in bacteria
HV128_RS01430	COG0151	Belongs to the GarS family
HV128_RS01460	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV128_RS01470	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HV128_RS01490	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV128_RS01495	COG3657	addiction module killer protein
HV128_RS01500	COG1187	pseudouridine synthase activity
HV128_RS01515	COG0527	aspartate kinase activity
HV128_RS01540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV128_RS01545	COG3223	Belongs to the PsiE family
HV128_RS01570	COG4580	involved in the transport of maltose and maltodextrins
HV128_RS01580	COG3161	chorismate lyase activity
HV128_RS01590	COG2937	Belongs to the GPAT DAPAT family
HV128_RS01595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV128_RS01600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV128_RS01605	COG0534	Mate efflux family protein
HV128_RS01610	COG3237	CsbD-like
HV128_RS01615	COG0735	belongs to the Fur family
HV128_RS01630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV128_RS01640	COG0604	alcohol dehydrogenase
HV128_RS01645	COG0305	Participates in initiation and elongation during chromosome replication
HV128_RS01655	COG1448	Aminotransferase
HV128_RS01660	COG3700	Belongs to the class B bacterial acid phosphatase family
HV128_RS01670	COG2315	Protein conserved in bacteria
HV128_RS01680	COG0629	single-stranded DNA binding
HV128_RS01695	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV128_RS01705	COG0789	Transcriptional regulator
HV128_RS01710	COG0625	glutathione transferase activity
HV128_RS01715	COG2252	PERMEase
HV128_RS01720	COG0025	NhaP-type Na H and K H
HV128_RS01725	COG0583	DNA-binding transcription factor activity
HV128_RS01735	COG1346	cytolysis
HV128_RS01740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV128_RS01745	COG3162	membrane
HV128_RS01755	COG1301	dicarboxylic acid transport
HV128_RS01760	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV128_RS01775	COG0745	RESPONSE REGULATOR receiver
HV128_RS01785	COG0191	fructose-bisphosphate aldolase activity
HV128_RS01800	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV128_RS01805	COG1129	ABC transporter
HV128_RS01810	COG4191	Histidine kinase
HV128_RS01810	COG0784	Response regulator, receiver
HV128_RS01820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV128_RS01825	COG0456	acetyltransferase
HV128_RS01830	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HV128_RS01835	COG3454	Phosphonate metabolism
HV128_RS01840	COG4778	phosphonate C-P lyase system protein PhnL
HV128_RS01845	COG4107	phosphonate C-P lyase system protein PhnK
HV128_RS01850	COG3627	carbon phosphorus lyase activity
HV128_RS01855	COG3626	phosphonate metabolism
HV128_RS01860	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV128_RS01865	COG3624	Phosphonate C-P lyase system protein PhnG
HV128_RS01870	COG2188	Transcriptional regulator
HV128_RS01875	COG3639	organic phosphonate transmembrane transporter activity
HV128_RS01880	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV128_RS01890	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV128_RS01895	COG2824	Alkylphosphonate utilization operon protein PhnA
HV128_RS01900	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HV128_RS01920	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV128_RS01960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV128_RS01965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV128_RS01970	COG1309	transcriptional regulator
HV128_RS02005	COG4145	pantothenate transmembrane transporter activity
HV128_RS02010	COG3924	membrane
HV128_RS02015	COG0439	Biotin carboxylase
HV128_RS02020	COG0511	ligase activity, forming carbon-carbon bonds
HV128_RS02025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HV128_RS02030	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HV128_RS02040	COG0604	alcohol dehydrogenase
HV128_RS02045	COG2200	EAL domain
HV128_RS02045	COG2199	diguanylate cyclase activity
HV128_RS02050	COG1077	Cell shape determining protein MreB Mrl
HV128_RS02055	COG1792	Involved in formation and maintenance of cell shape
HV128_RS02060	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV128_RS02070	COG1530	ribonuclease E activity
HV128_RS02075	COG3164	Protein of unknown function
HV128_RS02080	COG0312	modulator of DNA gyrase
HV128_RS02085	COG3477	response to acidic pH
HV128_RS02090	COG0583	DNA-binding transcription factor activity
HV128_RS02105	COG1289	transmembrane transporter activity
HV128_RS02110	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS02115	COG2732	(Barnase) inhibitor
HV128_RS02125	COG1438	arginine binding
HV128_RS02135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV128_RS02140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV128_RS02145	COG3105	Protein conserved in bacteria
HV128_RS02150	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV128_RS02160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HV128_RS02165	COG0625	glutathione transferase activity
HV128_RS02170	COG2969	positive regulation of protein catabolic process
HV128_RS02175	COG3539	Fimbrial protein
HV128_RS02180	COG3121	Chaperone
HV128_RS02185	COG3188	usher protein
HV128_RS02195	COG3539	Fimbrial protein
HV128_RS02200	COG0493	'glutamate synthase
HV128_RS02205	COG0070	glutamate synthase
HV128_RS02205	COG0069	glutamate synthase activity
HV128_RS02205	COG0067	glutamate synthase
HV128_RS02210	COG1242	4 iron, 4 sulfur cluster binding
HV128_RS02215	COG0433	COG0433 Predicted ATPase
HV128_RS02225	COG1064	alcohol dehydrogenase
HV128_RS02240	COG2927	DNA polymerase III (CHI subunit)
HV128_RS02245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV128_RS02250	COG0795	lipopolysaccharide-transporting ATPase activity
HV128_RS02255	COG0795	lipopolysaccharide-transporting ATPase activity
HV128_RS02260	COG5002	protein histidine kinase activity
HV128_RS02260	COG0784	Response regulator, receiver
HV128_RS02260	COG2198	Histidine kinase
HV128_RS02265	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV128_RS02275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS02295	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HV128_RS02300	COG1137	ATPase activity
HV128_RS02305	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV128_RS02310	COG3117	lipopolysaccharide transmembrane transporter activity
HV128_RS02315	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV128_RS02325	COG0530	calcium, potassium:sodium antiporter activity
HV128_RS02330	COG1127	ABC transporter
HV128_RS02335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV128_RS02340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV128_RS02345	COG2854	intermembrane phospholipid transfer
HV128_RS02350	COG3113	response to antibiotic
HV128_RS02355	COG5007	Belongs to the BolA IbaG family
HV128_RS02360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HV128_RS02365	COG3423	Transcriptional regulator
HV128_RS02370	COG0142	geranyltranstransferase activity
HV128_RS02375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV128_RS02385	COG0697	spore germination
HV128_RS02390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HV128_RS02395	COG0642	Histidine kinase
HV128_RS02400	COG0745	RESPONSE REGULATOR receiver
HV128_RS02405	COG2027	D-alanyl-D-alanine carboxypeptidase
HV128_RS02415	COG1534	Rna-binding protein
HV128_RS02420	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HV128_RS02425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV128_RS02430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV128_RS02435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV128_RS02440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV128_RS02450	COG0137	argininosuccinate synthase activity
HV128_RS02470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV128_RS02475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV128_RS02480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HV128_RS02485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HV128_RS02505	COG0513	Belongs to the DEAD box helicase family
HV128_RS02510	COG0814	amino acid
HV128_RS02515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV128_RS02520	COG0826	peptidase U32
HV128_RS02525	COG0826	peptidase U32
HV128_RS02530	COG3154	lipid carrier protein
HV128_RS02535	COG3153	acetyltransferase
HV128_RS02540	COG2827	Endonuclease containing a URI domain
HV128_RS02545	COG3787	Belongs to the UPF0306 family
HV128_RS02550	COG0693	protein deglycase activity
HV128_RS02555	COG0702	epimerase
HV128_RS02560	COG0701	Predicted permease
HV128_RS02565	COG2823	Periplasmic or secreted lipoprotein
HV128_RS02570	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HV128_RS02575	COG0792	nuclease activity
HV128_RS02580	COG3107	peptidoglycan biosynthetic process
HV128_RS02585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV128_RS02600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV128_RS02600	COG1263	PTS System
HV128_RS02605	COG0191	fructose-bisphosphate aldolase activity
HV128_RS02610	COG2222	sugar isomerase
HV128_RS02615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV128_RS02620	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS02625	COG3716	PTS system mannose fructose sorbose family IID component
HV128_RS02635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV128_RS02645	COG1349	DNA-binding transcription factor activity
HV128_RS02650	COG2721	sulfolactate sulfo-lyase activity
HV128_RS02660	COG2084	Dehydrogenase
HV128_RS02665	COG1929	Belongs to the glycerate kinase type-1 family
HV128_RS02675	COG0583	DNA-binding transcription factor activity
HV128_RS02680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV128_RS02685	COG0814	amino acid
HV128_RS02690	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HV128_RS02695	COG1882	Formate acetyltransferase
HV128_RS02700	COG0814	amino acid
HV128_RS02710	COG1741	Belongs to the pirin family
HV128_RS02715	COG0583	DNA-binding transcription factor activity
HV128_RS02720	COG3152	Membrane
HV128_RS02725	COG0435	Glutathione S-transferase
HV128_RS02740	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV128_RS02745	COG4575	ribosome binding
HV128_RS02750	COG1422	Protein of unknown function (DUF1090)
HV128_RS02760	COG0586	Pfam SNARE associated Golgi protein
HV128_RS02765	COG2186	Transcriptional regulator
HV128_RS02770	COG2271	Major facilitator Superfamily
HV128_RS02780	COG2721	sulfolactate sulfo-lyase activity
HV128_RS02790	COG0861	Integral membrane protein TerC family
HV128_RS02795	COG0673	inositol 2-dehydrogenase activity
HV128_RS02800	COG1451	nucleotide metabolic process
HV128_RS02810	COG1902	pentaerythritol trinitrate reductase activity
HV128_RS02810	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV128_RS02815	COG1070	Carbohydrate kinase
HV128_RS02820	COG2390	Transcriptional regulator
HV128_RS02825	COG1129	ABC transporter
HV128_RS02830	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV128_RS02835	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV128_RS02840	COG1879	ABC-type sugar transport system periplasmic component
HV128_RS02845	COG1830	Aldolase
HV128_RS02850	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV128_RS02865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV128_RS02870	COG0840	transmembrane signaling receptor activity
HV128_RS02875	COG0840	transmembrane signaling receptor activity
HV128_RS02880	COG1695	Transcriptional regulator
HV128_RS02885	COG2375	cellular response to nickel ion
HV128_RS02915	COG3663	DNA glycosylase
HV128_RS02925	COG0358	DNA primase activity
HV128_RS02930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV128_RS02940	COG2197	response regulator
HV128_RS02950	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV128_RS02955	COG0830	nickel cation binding
HV128_RS02965	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV128_RS02970	COG0804	urea catabolic process
HV128_RS02975	COG0832	Belongs to the urease beta subunit family
HV128_RS02980	COG0831	urea catabolic process
HV128_RS02985	COG0829	nickel cation binding
HV128_RS02990	COG0477	Major facilitator Superfamily
HV128_RS03000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV128_RS03010	COG0617	tRNA 3'-terminal CCA addition
HV128_RS03015	COG4991	sh3 domain protein
HV128_RS03020	COG3025	triphosphatase activity
HV128_RS03030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HV128_RS03030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HV128_RS03040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HV128_RS03045	COG3539	Fimbrial protein
HV128_RS03050	COG3121	Chaperone
HV128_RS03055	COG3188	usher protein
HV128_RS03060	COG3539	Fimbrial protein
HV128_RS03070	COG3384	dioxygenase
HV128_RS03075	COG0754	glutathionylspermidine amidase activity
HV128_RS03090	COG0494	nUDIX hydrolase
HV128_RS03095	COG3151	Protein conserved in bacteria
HV128_RS03100	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV128_RS03105	COG3150	esterase
HV128_RS03110	COG0187	DNA topoisomerase II activity
HV128_RS03125	COG2211	Major facilitator Superfamily
HV128_RS03130	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV128_RS03135	COG1652	LysM domain
HV128_RS03140	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV128_RS03145	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV128_RS03160	COG3111	PFAM Bacterial OB fold (BOF) protein
HV128_RS03215	COG2826	transposase and inactivated derivatives, IS30 family
HV128_RS03225	COG0640	Transcriptional regulator
HV128_RS03230	COG1902	pentaerythritol trinitrate reductase activity
HV128_RS03240	COG1234	tRNA 3'-trailer cleavage
HV128_RS03245	COG0697	spore germination
HV128_RS03315	COG0604	alcohol dehydrogenase
HV128_RS03360	COG1979	alcohol dehydrogenase
HV128_RS03365	COG2207	Transcriptional regulator
HV128_RS03370	COG0586	Pfam SNARE associated Golgi protein
HV128_RS03375	COG0626	cystathionine gamma-synthase activity
HV128_RS03385	COG0848	biopolymer transport protein
HV128_RS03405	COG2862	Uncharacterized protein family, UPF0114
HV128_RS03410	COG0667	Aldo Keto reductase
HV128_RS03415	COG0840	transmembrane signaling receptor activity
HV128_RS03420	COG1349	DNA-binding transcription factor activity
HV128_RS03425	COG0625	glutathione transferase activity
HV128_RS03430	COG0754	glutathionylspermidine amidase activity
HV128_RS03440	COG1215	transferase activity, transferring glycosyl groups
HV128_RS03445	COG0726	polysaccharide deacetylase
HV128_RS03445	COG1649	PFAM Uncharacterised BCR, COG1649
HV128_RS03450	COG0457	Tetratricopeptide repeat
HV128_RS03470	COG2197	response regulator
HV128_RS03475	COG5002	protein histidine kinase activity
HV128_RS03485	COG1811	Na channel or pump
HV128_RS03490	COG1982	Orn Lys Arg decarboxylase major
HV128_RS03505	COG3493	citrate carrier protein
HV128_RS03510	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV128_RS03520	COG3052	prosthetic group binding
HV128_RS03540	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HV128_RS03545	COG2211	Major facilitator Superfamily
HV128_RS03550	COG0741	lytic transglycosylase activity
HV128_RS03560	COG1194	a g-specific adenine glycosylase
HV128_RS03570	COG3171	Protein conserved in bacteria
HV128_RS03580	COG2852	Protein conserved in bacteria
HV128_RS03585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV128_RS03595	COG1872	DUF167
HV128_RS03600	COG0762	integral membrane protein
HV128_RS03605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV128_RS03610	COG2805	Type II/IV secretion system protein
HV128_RS03630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV128_RS03635	COG2356	endonuclease I
HV128_RS03640	COG3091	SprT-like family
HV128_RS03645	COG2814	Major facilitator Superfamily
HV128_RS03665	COG1166	arginine decarboxylase activity
HV128_RS03670	COG0010	Belongs to the arginase family
HV128_RS03680	COG2146	nitrite reductase [NAD(P)H] activity
HV128_RS03695	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS03700	COG1414	Transcriptional regulator
HV128_RS03725	COG2267	carboxylic ester hydrolase activity
HV128_RS03730	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS03735	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HV128_RS03750	COG0501	Belongs to the peptidase M48B family
HV128_RS03755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV128_RS03760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS03765	COG2213	PTS system mannitol-specific
HV128_RS03770	COG1063	alcohol dehydrogenase
HV128_RS03775	COG1494	fructose-1,6-bisphosphatase
HV128_RS03785	COG1072	(Pantothenic acid kinase))
HV128_RS03790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV128_RS03795	COG0126	phosphoglycerate kinase activity
HV128_RS03800	COG0191	fructose-bisphosphate aldolase activity
HV128_RS03805	COG0668	transmembrane transport
HV128_RS03810	COG1279	arginine transmembrane transporter activity
HV128_RS03815	COG2968	Membrane
HV128_RS03820	COG0583	DNA-binding transcription factor activity
HV128_RS03825	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HV128_RS03830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV128_RS03835	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV128_RS03845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HV128_RS03855	COG0006	proline dipeptidase activity
HV128_RS03860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV128_RS03865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV128_RS03870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HV128_RS03880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HV128_RS03880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HV128_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS03890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV128_RS03910	COG2723	6-phospho-beta-galactosidase activity
HV128_RS03915	COG1737	Transcriptional regulator
HV128_RS03920	COG1272	protein, Hemolysin III
HV128_RS03925	COG0354	folic acid binding
HV128_RS03930	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV128_RS03945	COG4974	Belongs to the 'phage' integrase family
HV128_RS03955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV128_RS03965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HV128_RS03970	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HV128_RS03975	COG4942	peptidase
HV128_RS04005	COG1335	isochorismatase
HV128_RS04010	COG2067	long-chain fatty acid transport protein
HV128_RS04030	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV128_RS04035	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS04040	COG3111	PFAM Bacterial OB fold (BOF) protein
HV128_RS04055	COG1546	Belongs to the CinA family
HV128_RS04070	COG1294	oxidase, subunit
HV128_RS04075	COG1271	oxidase subunit
HV128_RS04080	COG3546	catalase activity
HV128_RS04085	COG3685	Protein conserved in bacteria
HV128_RS04090	COG3685	Protein conserved in bacteria
HV128_RS04095	COG3729	General stress protein
HV128_RS04100	COG3592	Divergent 4Fe-4S mono-cluster
HV128_RS04105	COG2388	GCN5-related N-acetyl-transferase
HV128_RS04110	COG0814	amino acid
HV128_RS04125	COG0183	Belongs to the thiolase family
HV128_RS04135	COG0823	Involved in the tonB-independent uptake of proteins
HV128_RS04145	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS04150	COG2814	Major facilitator Superfamily
HV128_RS04160	COG3842	ATPase activity
HV128_RS04165	COG0395	ABC-type sugar transport system, permease component
HV128_RS04170	COG1175	transmembrane transport
HV128_RS04175	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV128_RS04185	COG1794	racemase activity, acting on amino acids and derivatives
HV128_RS04190	COG0583	DNA-binding transcription factor activity
HV128_RS04200	COG1609	Transcriptional regulator
HV128_RS04205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV128_RS04210	COG2723	6-phospho-beta-galactosidase activity
HV128_RS04215	COG2186	Transcriptional regulator
HV128_RS04225	COG1609	Transcriptional regulator
HV128_RS04230	COG0318	PFAM AMP-dependent synthetase and ligase
HV128_RS04230	COG0204	Acyl-transferase
HV128_RS04235	COG0477	Major facilitator Superfamily
HV128_RS04240	COG0667	Aldo Keto reductase
HV128_RS04250	COG3066	DNA modification
HV128_RS04255	COG0494	nUDIX hydrolase
HV128_RS04265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HV128_RS04270	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HV128_RS04275	COG2165	general secretion pathway protein
HV128_RS04280	COG4795	General secretion pathway protein
HV128_RS04290	COG4967	type IV pilus modification protein PilV
HV128_RS04295	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV128_RS04305	COG1074	ATP-dependent DNA helicase activity
HV128_RS04310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV128_RS04315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV128_RS04315	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV128_RS04320	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV128_RS04340	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV128_RS04345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV128_RS04350	COG2166	iron-sulfur cluster assembly
HV128_RS04355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV128_RS04365	COG0583	DNA-binding transcription factor activity
HV128_RS04370	COG2363	Small membrane protein
HV128_RS04375	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HV128_RS04385	COG1760	l-serine dehydratase
HV128_RS04390	COG0814	amino acid
HV128_RS04395	COG1611	Belongs to the LOG family
HV128_RS04410	COG3098	single-species biofilm formation
HV128_RS04415	COG0564	pseudouridine synthase activity
HV128_RS04420	COG0716	FMN binding
HV128_RS04425	COG2271	Major facilitator Superfamily
HV128_RS04430	COG4948	Mandelate Racemase Muconate Lactonizing
HV128_RS04435	COG4948	Mandelate Racemase Muconate Lactonizing
HV128_RS04440	COG1929	Belongs to the glycerate kinase type-1 family
HV128_RS04445	COG4999	Histidine kinase
HV128_RS04445	COG3437	response regulator, receiver
HV128_RS04445	COG3850	Histidine kinase
HV128_RS04445	COG2205	protein histidine kinase activity
HV128_RS04450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV128_RS04455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV128_RS04460	COG3956	TIGRFAM MazG family protein
HV128_RS04475	COG1737	Transcriptional regulator
HV128_RS04480	COG2190	(PTS) system
HV128_RS04480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV128_RS04480	COG1263	PTS System
HV128_RS04485	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV128_RS04490	COG0602	queuosine metabolic process
HV128_RS04500	COG1473	amidohydrolase
HV128_RS04510	COG0720	synthase
HV128_RS04515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HV128_RS04530	COG2234	aminopeptidase activity
HV128_RS04550	COG0529	Catalyzes the synthesis of activated sulfate
HV128_RS04560	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HV128_RS04565	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HV128_RS04570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HV128_RS04575	COG0585	pseudouridine synthase activity
HV128_RS04590	COG1388	LysM domain
HV128_RS04590	COG4942	peptidase
HV128_RS04605	COG0477	Major facilitator Superfamily
HV128_RS04620	COG0163	prenyltransferase activity
HV128_RS04625	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV128_RS04640	COG0582	viral genome integration into host DNA
HV128_RS04705	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV128_RS04715	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV128_RS04770	COG1120	ATPase activity
HV128_RS04775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV128_RS04790	COG0309	Hydrogenase expression formation protein (HypE)
HV128_RS04795	COG0409	Hydrogenase expression formation protein
HV128_RS04800	COG0298	carbon dioxide binding
HV128_RS04805	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV128_RS04810	COG0375	protein maturation
HV128_RS04820	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV128_RS04825	COG0651	ATP synthesis coupled electron transport
HV128_RS04830	COG0650	Formate hydrogenlyase subunit 4
HV128_RS04835	COG3261	NADH dehydrogenase
HV128_RS04835	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV128_RS04840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV128_RS04845	COG3260	NADH ubiquinone oxidoreductase 20
HV128_RS04855	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV128_RS04860	COG2723	6-phospho-beta-galactosidase activity
HV128_RS04865	COG1263	PTS System
HV128_RS04865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV128_RS04870	COG1609	Transcriptional regulator
HV128_RS04875	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV128_RS04880	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV128_RS04885	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV128_RS04890	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV128_RS04895	COG0426	domain, Protein
HV128_RS04895	COG1773	rubredoxin
HV128_RS04900	COG3604	Transcriptional regulator
HV128_RS04910	COG1349	DNA-binding transcription factor activity
HV128_RS04915	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS04930	COG3732	PTS system glucitol sorbitol-specific
HV128_RS04935	COG3730	PTS system glucitol sorbitol-specific
HV128_RS04940	COG2951	lytic endotransglycosylase activity
HV128_RS04950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV128_RS04960	COG1546	Belongs to the CinA family
HV128_RS04975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HV128_RS04980	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV128_RS05010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV128_RS05015	COG1238	metal cluster binding
HV128_RS05020	COG2918	glutathione biosynthetic process
HV128_RS05035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV128_RS05040	COG2814	Major facilitator Superfamily
HV128_RS05045	COG1566	PFAM secretion protein HlyD family protein
HV128_RS05050	COG1846	Transcriptional regulator
HV128_RS05055	COG2814	Major facilitator Superfamily
HV128_RS05065	COG4176	ABC-type proline glycine betaine transport system permease component
HV128_RS05070	COG4175	Glycine betaine
HV128_RS05080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV128_RS05085	COG1780	Probably involved in ribonucleotide reductase function
HV128_RS05095	COG4575	ribosome binding
HV128_RS05120	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV128_RS05125	COG0401	homolog of Blt101
HV128_RS05130	COG0583	DNA-binding transcription factor activity
HV128_RS05135	COG0666	response to abiotic stimulus
HV128_RS05140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV128_RS05145	COG1304	FMN binding
HV128_RS05155	COG0549	Belongs to the carbamate kinase family
HV128_RS05160	COG0402	S-adenosylhomocysteine deaminase activity
HV128_RS05175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV128_RS05180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV128_RS05205	COG4221	oxidoreductase activity
HV128_RS05215	COG3250	beta-galactosidase activity
HV128_RS05290	COG1073	alpha beta
HV128_RS05290	COG2226	methyltransferase
HV128_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS05325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HV128_RS05335	COG3842	ATPase activity
HV128_RS05350	COG0395	ABC-type sugar transport system, permease component
HV128_RS05355	COG4209	transmembrane transport
HV128_RS05360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV128_RS05420	COG0582	viral genome integration into host DNA
HV128_RS05435	COG2867	negative regulation of translational initiation
HV128_RS05450	COG0497	DNA recombination
HV128_RS05455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HV128_RS05465	COG4536	flavin adenine dinucleotide binding
HV128_RS05470	COG4137	Cytochrome C assembly protein
HV128_RS05475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV128_RS05485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HV128_RS05490	COG0336	Belongs to the RNA methyltransferase TrmD family
HV128_RS05510	COG2885	chlorophyll binding
HV128_RS05515	COG2199	diguanylate cyclase activity
HV128_RS05530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV128_RS05535	COG1605	Chorismate mutase
HV128_RS05535	COG0287	Prephenate dehydrogenase
HV128_RS05545	COG0077	Prephenate dehydratase
HV128_RS05545	COG1605	Chorismate mutase
HV128_RS05555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV128_RS05560	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV128_RS05565	COG0564	pseudouridine synthase activity
HV128_RS05575	COG0542	response to heat
HV128_RS05605	COG0477	Major facilitator Superfamily
HV128_RS05610	COG5544	Lipoprotein
HV128_RS05615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV128_RS05620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV128_RS05620	COG1042	CoA-binding domain protein
HV128_RS05620	COG0045	succinate-CoA ligase (ADP-forming) activity
HV128_RS05630	COG3118	belongs to the thioredoxin family
HV128_RS05635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV128_RS05640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HV128_RS05645	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HV128_RS05650	COG0513	Belongs to the DEAD box helicase family
HV128_RS05655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HV128_RS05660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV128_RS05670	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HV128_RS05680	COG3086	response to oxidative stress
HV128_RS05825	COG0305	Participates in initiation and elongation during chromosome replication
HV128_RS05875	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HV128_RS05925	COG1783	phage Terminase large subunit
HV128_RS06120	COG0681	Belongs to the peptidase S26 family
HV128_RS06135	COG1381	Involved in DNA repair and RecF pathway recombination
HV128_RS06140	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV128_RS06150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV128_RS06155	COG1737	Transcriptional regulator
HV128_RS06160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV128_RS06165	COG1263	PTS System
HV128_RS06165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV128_RS06170	COG0560	Phosphoserine phosphatase
HV128_RS06180	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV128_RS06185	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HV128_RS06185	COG0047	phosphoribosylformylglycinamidine synthase activity
HV128_RS06190	COG2205	protein histidine kinase activity
HV128_RS06195	COG3170	Tfp pilus assembly protein FimV
HV128_RS06200	COG2204	response regulator
HV128_RS06205	COG0347	Belongs to the P(II) protein family
HV128_RS06210	COG1017	nitric oxide dioxygenase activity
HV128_RS06210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV128_RS06220	COG2259	Doxx family
HV128_RS06225	COG2814	Major facilitator Superfamily
HV128_RS06230	COG3711	transcriptional antiterminator
HV128_RS06240	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV128_RS06260	COG1104	cysteine desulfurase activity
HV128_RS06265	COG0822	iron-sulfur transferase activity
HV128_RS06270	COG0316	Belongs to the HesB IscA family
HV128_RS06275	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV128_RS06280	COG0443	Heat shock 70 kDa protein
HV128_RS06285	COG0633	Ferredoxin
HV128_RS06290	COG2975	iron-sulfur cluster assembly
HV128_RS06295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV128_RS06305	COG1737	Transcriptional regulator
HV128_RS06310	COG2897	thiosulfate sulfurtransferase activity
HV128_RS06320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV128_RS06320	COG1263	PTS System
HV128_RS06320	COG2190	(PTS) system
HV128_RS06325	COG2373	Large extracellular alpha-helical protein
HV128_RS06330	COG4953	penicillin-binding protein 1C
HV128_RS06335	COG0243	molybdopterin cofactor binding
HV128_RS06340	COG0437	4 iron, 4 sulfur cluster binding
HV128_RS06350	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV128_RS06360	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HV128_RS06370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HV128_RS06375	COG0124	histidyl-tRNA synthetase
HV128_RS06380	COG2976	Protein conserved in bacteria
HV128_RS06390	COG1160	GTP binding
HV128_RS06395	COG3104	oligopeptide transport
HV128_RS06400	COG1645	bacterial-type flagellum-dependent swarming motility
HV128_RS06415	COG1570	exodeoxyribonuclease VII activity
HV128_RS06420	COG0517	IMP dehydrogenase activity
HV128_RS06420	COG0516	GMP reductase activity
HV128_RS06435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV128_RS06455	COG0745	RESPONSE REGULATOR receiver
HV128_RS06460	COG3713	MltA-interacting MipA family protein
HV128_RS06475	COG2200	EAL domain
HV128_RS06490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV128_RS06500	COG2723	6-phospho-beta-galactosidase activity
HV128_RS06505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HV128_RS06510	COG2233	PERMEase
HV128_RS06520	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV128_RS06525	COG1446	asparaginase
HV128_RS06540	COG1393	Belongs to the ArsC family
HV128_RS06545	COG4783	chaperone-mediated protein folding
HV128_RS06550	COG0628	permease
HV128_RS06555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV128_RS06560	COG2716	regulation of RNA biosynthetic process
HV128_RS06570	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV128_RS06575	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HV128_RS06580	COG2321	neutral zinc metallopeptidase
HV128_RS06590	COG0400	carboxylic ester hydrolase activity
HV128_RS06600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV128_RS06605	COG1393	Belongs to the ArsC family
HV128_RS06615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV128_RS06620	COG3850	Histidine kinase
HV128_RS06625	COG0493	'glutamate synthase
HV128_RS06625	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV128_RS06630	COG0494	nUDIX hydrolase
HV128_RS06635	COG5342	invasion associated locus B
HV128_RS06640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV128_RS06655	COG0408	coproporphyrinogen oxidase activity
HV128_RS06680	COG2837	iron assimilation
HV128_RS06685	COG4150	thiosulfate binding
HV128_RS06690	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV128_RS06695	COG4208	sulfate ABC transporter
HV128_RS06700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV128_RS06725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS06740	COG3115	cell septum assembly
HV128_RS06745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HV128_RS06750	COG3530	Putative quorum-sensing-regulated virulence factor
HV128_RS06755	COG0385	Bile acid
HV128_RS06760	COG0583	DNA-binding transcription factor activity
HV128_RS06790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV128_RS06795	COG3415	Transposase
HV128_RS06800	COG3415	Transposase
HV128_RS06815	COG2200	EAL domain
HV128_RS06815	COG2199	diguanylate cyclase activity
HV128_RS06820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV128_RS06825	COG1914	H( )-stimulated, divalent metal cation uptake system
HV128_RS06835	COG0667	Aldo Keto reductase
HV128_RS06840	COG3961	Belongs to the TPP enzyme family
HV128_RS06850	COG0837	glucose binding
HV128_RS06855	COG3279	Response regulator of the LytR AlgR family
HV128_RS06860	COG3275	phosphorelay sensor kinase activity
HV128_RS06870	COG0436	Aminotransferase
HV128_RS06880	COG1560	Kdo2-lipid A biosynthetic process
HV128_RS06885	COG3706	GGDEF domain
HV128_RS06905	COG2003	Belongs to the UPF0758 family
HV128_RS06935	COG2378	regulation of single-species biofilm formation
HV128_RS06940	COG3596	GTP binding
HV128_RS06980	COG2826	transposase and inactivated derivatives, IS30 family
HV128_RS06990	COG3344	reverse transcriptase
HV128_RS07025	COG2223	nitrite transmembrane transporter activity
HV128_RS07035	COG1609	Transcriptional regulator
HV128_RS07055	COG2003	Belongs to the UPF0758 family
HV128_RS07095	COG3596	GTP binding
HV128_RS07170	COG0582	viral genome integration into host DNA
HV128_RS07185	COG2116	formate transmembrane transporter activity
HV128_RS07195	COG2067	long-chain fatty acid transport protein
HV128_RS07200	COG3691	Protein conserved in bacteria
HV128_RS07210	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV128_RS07210	COG1024	Enoyl-CoA hydratase
HV128_RS07215	COG2062	phosphohistidine phosphatase, SixA
HV128_RS07220	COG2840	Smr protein MutS2
HV128_RS07240	COG0730	response to heat
HV128_RS07245	COG3101	peptidyl-lysine hydroxylation
HV128_RS07255	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HV128_RS07255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV128_RS07260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV128_RS07275	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV128_RS07280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV128_RS07285	COG0101	tRNA pseudouridine synthase activity
HV128_RS07290	COG0586	Pfam SNARE associated Golgi protein
HV128_RS07300	COG0285	dihydrofolate synthase activity
HV128_RS07305	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV128_RS07310	COG1286	toxin biosynthetic process
HV128_RS07315	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV128_RS07320	COG0163	prenyltransferase activity
HV128_RS07330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV128_RS07340	COG4160	amino acid transport
HV128_RS07345	COG4598	ABC transporter
HV128_RS07350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV128_RS07355	COG1090	epimerase
HV128_RS07360	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV128_RS07365	COG0625	glutathione transferase activity
HV128_RS07370	COG0625	glutathione transferase activity
HV128_RS07375	COG0622	Phosphoesterase
HV128_RS07385	COG1609	Transcriptional regulator
HV128_RS07390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS07400	COG3037	sugar-specific permease SgaT UlaA
HV128_RS07405	COG3959	Transketolase, thiamine diphosphate binding domain
HV128_RS07410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV128_RS07435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV128_RS07440	COG0490	domain, Protein
HV128_RS07440	COG0471	metal ion transport
HV128_RS07450	COG0436	Aminotransferase
HV128_RS07455	COG0583	DNA-binding transcription factor activity
HV128_RS07460	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV128_RS07490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HV128_RS07500	COG0839	Belongs to the complex I subunit 6 family
HV128_RS07505	COG0713	ATP synthesis coupled electron transport
HV128_RS07510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV128_RS07515	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV128_RS07520	COG1007	ATP synthesis coupled electron transport
HV128_RS07525	COG0835	chemotaxis
HV128_RS07525	COG0784	Response regulator, receiver
HV128_RS07530	COG1234	tRNA 3'-trailer cleavage
HV128_RS07535	COG2153	protein acetylation
HV128_RS07540	COG4575	ribosome binding
HV128_RS07545	COG1169	isochorismate synthase
HV128_RS07550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HV128_RS07555	COG0596	Alpha beta hydrolase
HV128_RS07565	COG1441	menaquinone biosynthetic process
HV128_RS07595	COG0642	Histidine kinase
HV128_RS07610	COG0247	lactate metabolic process
HV128_RS07615	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HV128_RS07620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV128_RS07625	COG2271	Major facilitator Superfamily
HV128_RS07630	COG0584	glycerophosphoryl diester phosphodiesterase
HV128_RS07635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV128_RS07650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV128_RS07670	COG0642	Histidine kinase
HV128_RS07670	COG2198	Histidine kinase
HV128_RS07675	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV128_RS07685	COG2169	Transcriptional regulator
HV128_RS07685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV128_RS07695	COG4615	Cyclic peptide transporter
HV128_RS07700	COG2239	Acts as a magnesium transporter
HV128_RS07705	COG0659	secondary active sulfate transmembrane transporter activity
HV128_RS07710	COG0579	oxidoreductase
HV128_RS07720	COG3182	Iron-regulated membrane protein
HV128_RS07735	COG3082	Protein of unknown function (DUF1414)
HV128_RS07740	COG3081	Nucleoid-associated protein
HV128_RS07750	COG1061	Type III restriction enzyme res subunit
HV128_RS07755	COG1187	pseudouridine synthase activity
HV128_RS07760	COG2814	Major facilitator Superfamily
HV128_RS07770	COG4172	Belongs to the ABC transporter superfamily
HV128_RS07775	COG4239	(ABC) transporter, permease
HV128_RS07780	COG4174	ABC transporter (Permease)
HV128_RS07785	COG4166	transmembrane transport
HV128_RS07790	COG2200	EAL domain
HV128_RS07795	COG0791	NLP P60 protein
HV128_RS07800	COG0671	phosphoesterase, PA-phosphatase related
HV128_RS07805	COG0523	cobalamin synthesis protein
HV128_RS07810	COG0246	Mannitol dehydrogenase
HV128_RS07815	COG1312	Catalyzes the dehydration of D-mannonate
HV128_RS07820	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HV128_RS07835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS07835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS07840	COG1105	Belongs to the carbohydrate kinase PfkB family
HV128_RS07845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV128_RS07845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV128_RS07845	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV128_RS07850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HV128_RS07855	COG2855	membrane
HV128_RS07860	COG0583	DNA-binding transcription factor activity
HV128_RS07865	COG0833	amino acid
HV128_RS07870	COG4771	TonB-dependent receptor
HV128_RS07875	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HV128_RS07880	COG0477	Major facilitator Superfamily
HV128_RS07890	COG2311	Membrane
HV128_RS07905	COG1129	ABC transporter
HV128_RS07925	COG2949	membrane
HV128_RS07930	COG0295	cytidine deaminase activity
HV128_RS07935	COG1346	cytolysis
HV128_RS07945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV128_RS07950	COG1538	Outer membrane efflux protein
HV128_RS07955	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS07960	COG0586	Pfam SNARE associated Golgi protein
HV128_RS07970	COG1686	Belongs to the peptidase S11 family
HV128_RS07980	COG0277	FAD linked oxidase domain protein
HV128_RS07985	COG1472	Belongs to the glycosyl hydrolase 3 family
HV128_RS07990	COG1732	Glycine betaine
HV128_RS07995	COG1174	glycine betaine transport
HV128_RS08000	COG1125	glycine betaine transport
HV128_RS08005	COG1174	glycine betaine transport
HV128_RS08015	COG0789	Transcriptional regulator
HV128_RS08020	COG3275	phosphorelay sensor kinase activity
HV128_RS08025	COG3279	Response regulator of the LytR AlgR family
HV128_RS08030	COG4807	Protein conserved in bacteria
HV128_RS08040	COG0489	protein tyrosine kinase activity
HV128_RS08050	COG5455	response to cobalt ion
HV128_RS08055	COG1596	polysaccharide export
HV128_RS08060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HV128_RS08065	COG0489	protein tyrosine kinase activity
HV128_RS08065	COG3206	protein involved in exopolysaccharide biosynthesis
HV128_RS08070	COG0076	glutamate decarboxylase activity
HV128_RS08075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV128_RS08090	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HV128_RS08095	COG0351	phosphomethylpyrimidine kinase
HV128_RS08100	COG2188	Transcriptional regulator
HV128_RS08105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV128_RS08110	COG1397	ADP-ribosylglycohydrolase
HV128_RS08115	COG2211	Major facilitator Superfamily
HV128_RS08120	COG1830	Aldolase
HV128_RS08125	COG1597	lipid kinase activity
HV128_RS08140	COG0745	RESPONSE REGULATOR receiver
HV128_RS08145	COG2205	protein histidine kinase activity
HV128_RS08150	COG0477	Major facilitator Superfamily
HV128_RS08155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV128_RS08160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV128_RS08165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV128_RS08170	COG0443	Heat shock 70 kDa protein
HV128_RS08175	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV128_RS08180	COG5001	Diguanylate cyclase
HV128_RS08180	COG3447	MASE1 domain protein
HV128_RS08180	COG5002	protein histidine kinase activity
HV128_RS08190	COG0717	Belongs to the dCTP deaminase family
HV128_RS08195	COG2982	Protein involved in outer membrane biogenesis
HV128_RS08200	COG1253	flavin adenine dinucleotide binding
HV128_RS08215	COG3206	protein involved in exopolysaccharide biosynthesis
HV128_RS08215	COG0489	protein tyrosine kinase activity
HV128_RS08220	COG0463	Glycosyl transferase, family 2
HV128_RS08225	COG1045	serine acetyltransferase
HV128_RS08230	COG0438	transferase activity, transferring glycosyl groups
HV128_RS08240	COG1216	Glycosyl transferase, family 2
HV128_RS08245	COG0110	maltose O-acetyltransferase activity
HV128_RS08250	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV128_RS08255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV128_RS08260	COG1051	belongs to the nudix hydrolase family
HV128_RS08265	COG0297	glycogen (starch) synthase activity
HV128_RS08275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV128_RS08280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV128_RS08285	COG2244	polysaccharide biosynthetic process
HV128_RS08290	COG2327	Polysaccharide pyruvyl transferase
HV128_RS08295	COG0438	transferase activity, transferring glycosyl groups
HV128_RS08305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV128_RS08315	COG0438	transferase activity, transferring glycosyl groups
HV128_RS08325	COG1216	Glycosyl transferase, family 2
HV128_RS08325	COG0463	Glycosyl transferase, family 2
HV128_RS08340	COG0438	transferase activity, transferring glycosyl groups
HV128_RS08355	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HV128_RS08360	COG1088	dTDP-glucose 4,6-dehydratase activity
HV128_RS08390	COG0107	imidazoleglycerol-phosphate synthase activity
HV128_RS08395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HV128_RS08400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV128_RS08405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV128_RS08405	COG0131	Imidazoleglycerol-phosphate dehydratase
HV128_RS08410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV128_RS08420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HV128_RS08430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV128_RS08435	COG0583	DNA-binding transcription factor activity
HV128_RS08445	COG0531	amino acid
HV128_RS08450	COG2925	Exonuclease
HV128_RS08460	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV128_RS08465	COG1289	transmembrane transporter activity
HV128_RS08480	COG0534	Mate efflux family protein
HV128_RS08490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV128_RS08495	COG0477	Major facilitator Superfamily
HV128_RS08510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV128_RS08520	COG0589	response to stress
HV128_RS08525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HV128_RS08550	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HV128_RS08600	COG0583	DNA-binding transcription factor activity
HV128_RS08625	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV128_RS08625	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV128_RS08645	COG4565	transcriptional regulatory protein
HV128_RS08650	COG3290	protein histidine kinase activity
HV128_RS08660	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV128_RS08665	COG1418	mRNA catabolic process
HV128_RS08670	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV128_RS08675	COG3727	T/G mismatch-specific endonuclease activity
HV128_RS08680	COG0697	spore germination
HV128_RS08685	COG2354	Protein conserved in bacteria
HV128_RS08690	COG5475	Uncharacterized small protein (DUF2158)
HV128_RS08715	COG2197	response regulator
HV128_RS08725	COG1987	bacterial-type flagellum assembly
HV128_RS08765	COG1157	protein secretion by the type III secretion system
HV128_RS08775	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HV128_RS08785	COG1677	Flagellar hook-basal body complex protein FliE
HV128_RS08795	COG0366	Alpha amylase catalytic
HV128_RS08805	COG1516	flagellar protein fliS
HV128_RS08810	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV128_RS08815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV128_RS08850	COG2197	response regulator
HV128_RS08860	COG2197	response regulator
HV128_RS08890	COG0583	DNA-binding transcription factor activity
HV128_RS08925	COG3012	SEC-C Motif Domain Protein
HV128_RS08925	COG3318	Belongs to the UPF0149 family
HV128_RS08930	COG0814	amino acid
HV128_RS08940	COG1528	Iron-storage protein
HV128_RS08970	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV128_RS08975	COG1528	Iron-storage protein
HV128_RS08985	COG1879	ABC-type sugar transport system periplasmic component
HV128_RS08995	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV128_RS09005	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HV128_RS09045	COG1301	dicarboxylic acid transport
HV128_RS09080	COG0840	transmembrane signaling receptor activity
HV128_RS09095	COG0745	RESPONSE REGULATOR receiver
HV128_RS09145	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV128_RS09150	COG0018	arginyl-trna synthetase
HV128_RS09155	COG3102	Protein conserved in bacteria
HV128_RS09160	COG3142	Participates in the control of copper homeostasis
HV128_RS09165	COG0500	methyltransferase
HV128_RS09170	COG2226	methyltransferase
HV128_RS09175	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV128_RS09180	COG1801	Protein of unknown function DUF72
HV128_RS09185	COG0582	viral genome integration into host DNA
HV128_RS09235	COG4197	protein conserved in bacteria, prophage-related
HV128_RS09245	COG1802	Transcriptional regulator
HV128_RS09245	COG4626	Terminase
HV128_RS09255	COG0484	heat shock protein binding
HV128_RS09275	COG3179	chitinase
HV128_RS09320	COG1802	Transcriptional regulator
HV128_RS09320	COG4626	Terminase
HV128_RS09325	COG4695	Portal protein
HV128_RS09330	COG0740	serine-type endopeptidase activity
HV128_RS09440	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV128_RS09455	COG1335	isochorismatase
HV128_RS09465	COG0494	nUDIX hydrolase
HV128_RS09480	COG0632	four-way junction helicase activity
HV128_RS09485	COG2255	four-way junction helicase activity
HV128_RS09490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV128_RS09500	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV128_RS09505	COG0739	heme binding
HV128_RS09510	COG1560	Kdo2-lipid A biosynthetic process
HV128_RS09520	COG1737	Transcriptional regulator
HV128_RS09525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV128_RS09530	COG0129	dihydroxy-acid dehydratase activity
HV128_RS09535	COG0800	Aldolase
HV128_RS09545	COG2979	Protein of unknown function (DUF533)
HV128_RS09550	COG1770	oligopeptidase
HV128_RS09555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV128_RS09560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV128_RS09570	COG2372	response to copper ion
HV128_RS09575	COG1276	copper resistance
HV128_RS09590	COG2990	Protein conserved in bacteria
HV128_RS09605	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HV128_RS09605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HV128_RS09610	COG3008	intermembrane lipid transfer
HV128_RS09615	COG2995	paraquat-inducible protein a
HV128_RS09620	COG1956	GAF domain-containing protein
HV128_RS09625	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HV128_RS09635	COG0501	Belongs to the peptidase M48B family
HV128_RS09640	COG2814	Major facilitator Superfamily
HV128_RS09645	COG1414	Transcriptional regulator
HV128_RS09675	COG0768	penicillin binding
HV128_RS09680	COG2226	methyltransferase
HV128_RS09685	COG1971	Probably functions as a manganese efflux pump
HV128_RS09690	COG4811	Protein of unknown function (DUF986)
HV128_RS09695	COG3716	PTS system mannose fructose sorbose family IID component
HV128_RS09700	COG3715	PTS system
HV128_RS09705	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS09705	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV128_RS09710	COG1253	flavin adenine dinucleotide binding
HV128_RS09715	COG2200	EAL domain
HV128_RS09720	COG1760	l-serine dehydratase
HV128_RS09725	COG0494	nUDIX hydrolase
HV128_RS09740	COG0251	oxidation-reduction process
HV128_RS09745	COG1199	ATP-dependent helicase activity
HV128_RS09750	COG1214	PFAM Peptidase M22, glycoprotease
HV128_RS09755	COG3065	identical protein binding
HV128_RS09760	COG0318	PFAM AMP-dependent synthetase and ligase
HV128_RS09765	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV128_RS09770	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HV128_RS09775	COG2894	cell division
HV128_RS09780	COG0850	regulation of cytokinetic process
HV128_RS09790	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV128_RS09795	COG2983	Belongs to the UPF0260 family
HV128_RS09805	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV128_RS09815	COG2719	SpoVR family
HV128_RS09820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV128_RS09825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV128_RS09830	COG3263	regulation of cellular component size
HV128_RS09835	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV128_RS09840	COG0741	lytic transglycosylase activity
HV128_RS09850	COG4774	siderophore transport
HV128_RS09865	COG2814	Major facilitator Superfamily
HV128_RS09875	COG4977	sequence-specific DNA binding
HV128_RS09990	COG0515	serine threonine protein kinase
HV128_RS10005	COG3501	Rhs element vgr protein
HV128_RS10050	COG0012	GTP binding
HV128_RS10055	COG0193	aminoacyl-tRNA hydrolase activity
HV128_RS10070	COG0659	secondary active sulfate transmembrane transporter activity
HV128_RS10080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HV128_RS10090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HV128_RS10100	COG2890	protein-(glutamine-N5) methyltransferase activity
HV128_RS10115	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HV128_RS10120	COG0387	Pfam Sodium calcium exchanger
HV128_RS10125	COG4572	Cation transport regulator
HV128_RS10130	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV128_RS10140	COG0840	transmembrane signaling receptor activity
HV128_RS10145	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV128_RS10150	COG3707	response regulator
HV128_RS10155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV128_RS10165	COG1116	anion transmembrane transporter activity
HV128_RS10170	COG2146	nitrite reductase [NAD(P)H] activity
HV128_RS10170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV128_RS10175	COG0243	molybdopterin cofactor binding
HV128_RS10180	COG4932	domain protein
HV128_RS10185	COG2197	response regulator
HV128_RS10190	COG3850	Histidine kinase
HV128_RS10195	COG2223	nitrite transmembrane transporter activity
HV128_RS10200	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV128_RS10205	COG1140	nitrate reductase beta subunit
HV128_RS10210	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV128_RS10215	COG2181	nitrate reductase activity
HV128_RS10230	COG0788	formyltetrahydrofolate deformylase activity
HV128_RS10235	COG3012	SEC-C Motif Domain Protein
HV128_RS10240	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV128_RS10245	COG0745	RESPONSE REGULATOR receiver
HV128_RS10250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV128_RS10260	COG1435	thymidine kinase activity
HV128_RS10265	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS10265	COG1454	alcohol dehydrogenase
HV128_RS10270	COG2095	MarC family integral membrane protein
HV128_RS10290	COG0444	Belongs to the ABC transporter superfamily
HV128_RS10295	COG4608	Belongs to the ABC transporter superfamily
HV128_RS10300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV128_RS10305	COG3099	Belongs to the UPF0263 family
HV128_RS10325	COG1280	lysine exporter protein (LysE YggA)
HV128_RS10330	COG2350	Protein conserved in bacteria
HV128_RS10360	COG0727	PFAM Uncharacterised protein family (UPF0153)
HV128_RS10365	COG3047	cAMP biosynthetic process
HV128_RS10370	COG0425	Belongs to the sulfur carrier protein TusA family
HV128_RS10375	COG2391	methyltransferase activity
HV128_RS10380	COG0159	tryptophan synthase activity
HV128_RS10385	COG0133	tryptophan synthase activity
HV128_RS10395	COG0512	Glutamine amidotransferase of anthranilate synthase
HV128_RS10395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV128_RS10415	COG0009	L-threonylcarbamoyladenylate synthase
HV128_RS10425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HV128_RS10430	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS10435	COG0616	signal peptide processing
HV128_RS10465	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV128_RS10475	COG0671	phosphoesterase, PA-phosphatase related
HV128_RS10480	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV128_RS10485	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV128_RS10490	COG0284	orotidine-5'-phosphate decarboxylase activity
HV128_RS10495	COG0023	Translation Initiation Factor
HV128_RS10505	COG1349	DNA-binding transcription factor activity
HV128_RS10515	COG1024	Enoyl-CoA hydratase
HV128_RS10520	COG5001	Diguanylate cyclase
HV128_RS10530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV128_RS10530	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV128_RS10535	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV128_RS10540	COG3706	GGDEF domain
HV128_RS10545	COG3708	Transcriptional regulator
HV128_RS10545	COG2207	Transcriptional regulator
HV128_RS10550	COG0251	oxidation-reduction process
HV128_RS10560	COG4172	Belongs to the ABC transporter superfamily
HV128_RS10570	COG4171	peptide transport system, permease
HV128_RS10585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV128_RS10590	COG1842	Phage shock protein A
HV128_RS10600	COG1983	PspC domain protein
HV128_RS10610	COG0366	Alpha amylase catalytic
HV128_RS10615	COG1653	transport
HV128_RS10620	COG1175	transmembrane transport
HV128_RS10625	COG0395	ABC-type sugar transport system, permease component
HV128_RS10630	COG1063	alcohol dehydrogenase
HV128_RS10635	COG1082	Xylose isomerase domain protein TIM barrel
HV128_RS10640	COG0673	inositol 2-dehydrogenase activity
HV128_RS10645	COG1554	hydrolase, family 65, central catalytic
HV128_RS10650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV128_RS10655	COG3842	ATPase activity
HV128_RS10665	COG1609	Transcriptional regulator
HV128_RS10670	COG3106	COG3106 Predicted ATPase
HV128_RS10675	COG3768	UPF0283 membrane protein
HV128_RS10685	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV128_RS10690	COG4948	Mandelate Racemase Muconate Lactonizing
HV128_RS10695	COG2866	Carboxypeptidase
HV128_RS10700	COG4166	transmembrane transport
HV128_RS10725	COG2885	chlorophyll binding
HV128_RS10750	COG3501	Rhs element vgr protein
HV128_RS10775	COG2826	transposase and inactivated derivatives, IS30 family
HV128_RS10790	COG0789	Transcriptional regulator
HV128_RS10860	COG0840	transmembrane signaling receptor activity
HV128_RS10875	COG0513	Belongs to the DEAD box helicase family
HV128_RS10885	COG0582	viral genome integration into host DNA
HV128_RS10905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV128_RS10910	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV128_RS10910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV128_RS10910	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV128_RS10910	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV128_RS10915	COG3042	response to heat
HV128_RS10920	COG3187	Heat shock protein
HV128_RS10930	COG1294	oxidase, subunit
HV128_RS10935	COG1271	oxidase subunit
HV128_RS10945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV128_RS10950	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS10960	COG3615	Tellurite resistance protein tehB
HV128_RS10965	COG3615	Tellurite resistance protein tehB
HV128_RS10995	COG0747	negative chemotaxis
HV128_RS11005	COG3238	Protein conserved in bacteria
HV128_RS11010	COG1247	-acetyltransferase
HV128_RS11020	COG2130	NADP-dependent
HV128_RS11025	COG1802	Transcriptional regulator
HV128_RS11030	COG4772	TonB-dependent receptor
HV128_RS11055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV128_RS11060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV128_RS11065	COG1473	amidohydrolase
HV128_RS11070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV128_RS11075	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV128_RS11090	COG1126	abc transporter atp-binding protein
HV128_RS11100	COG0625	glutathione transferase activity
HV128_RS11105	COG1942	4-Oxalocrotonate Tautomerase
HV128_RS11110	COG1560	Kdo2-lipid A biosynthetic process
HV128_RS11120	COG0640	Transcriptional regulator
HV128_RS11125	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HV128_RS11130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV128_RS11135	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV128_RS11145	COG2181	nitrate reductase activity
HV128_RS11150	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV128_RS11155	COG1140	nitrate reductase beta subunit
HV128_RS11160	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV128_RS11165	COG2223	nitrite transmembrane transporter activity
HV128_RS11195	COG0437	4 iron, 4 sulfur cluster binding
HV128_RS11200	COG2864	formate dehydrogenase
HV128_RS11210	COG2814	Major facilitator Superfamily
HV128_RS11215	COG1252	NADH dehydrogenase
HV128_RS11225	COG1064	alcohol dehydrogenase
HV128_RS11230	COG0488	(ABC) transporter
HV128_RS11235	COG0281	malic enzyme
HV128_RS11265	COG1764	response to oxidative stress
HV128_RS11270	COG4608	Belongs to the ABC transporter superfamily
HV128_RS11275	COG0444	Belongs to the ABC transporter superfamily
HV128_RS11280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV128_RS11285	COG0601	transmembrane transport
HV128_RS11290	COG0747	negative chemotaxis
HV128_RS11295	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV128_RS11310	COG2200	EAL domain
HV128_RS11370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV128_RS11380	COG4628	conserved protein (DUF2132)
HV128_RS11385	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV128_RS11390	COG0583	DNA-binding transcription factor activity
HV128_RS11400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV128_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS11415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HV128_RS11450	COG2814	Major facilitator Superfamily
HV128_RS11475	COG1349	DNA-binding transcription factor activity
HV128_RS11480	COG0494	nUDIX hydrolase
HV128_RS11500	COG0745	RESPONSE REGULATOR receiver
HV128_RS11505	COG0596	Alpha beta hydrolase
HV128_RS11525	COG3781	membrane
HV128_RS11530	COG0246	Mannitol dehydrogenase
HV128_RS11540	COG3706	GGDEF domain
HV128_RS11550	COG2066	Belongs to the glutaminase family
HV128_RS11560	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS11565	COG0583	DNA-binding transcription factor activity
HV128_RS11580	COG2814	Major facilitator Superfamily
HV128_RS11590	COG1846	Transcriptional regulator
HV128_RS11605	COG0697	spore germination
HV128_RS11610	COG2814	Major facilitator Superfamily
HV128_RS11615	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV128_RS11625	COG1122	ATPase activity
HV128_RS11645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV128_RS11670	COG0826	peptidase U32
HV128_RS11675	COG1396	sequence-specific DNA binding
HV128_RS11680	COG3135	benzoate transporter
HV128_RS11700	COG0747	negative chemotaxis
HV128_RS11705	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV128_RS11710	COG0500	methyltransferase
HV128_RS11715	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV128_RS11720	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV128_RS11725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV128_RS11730	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HV128_RS11740	COG0436	Aminotransferase
HV128_RS11755	COG5383	Protein conserved in bacteria
HV128_RS11760	COG0583	DNA-binding transcription factor activity
HV128_RS11765	COG0840	transmembrane signaling receptor activity
HV128_RS11835	COG2274	protein secretion by the type I secretion system
HV128_RS11850	COG1349	DNA-binding transcription factor activity
HV128_RS11855	COG0673	inositol 2-dehydrogenase activity
HV128_RS11860	COG3038	cytochrome b561
HV128_RS11865	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS11870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV128_RS11890	COG1643	Atp-dependent helicase
HV128_RS11900	COG0564	pseudouridine synthase activity
HV128_RS11905	COG3122	Protein conserved in bacteria
HV128_RS11950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV128_RS11965	COG0300	oxidoreductase activity
HV128_RS11985	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV128_RS11995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV128_RS12000	COG3327	negative regulation of DNA-templated transcription, initiation
HV128_RS12005	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HV128_RS12010	COG0183	Belongs to the thiolase family
HV128_RS12015	COG2050	protein possibly involved in aromatic compounds catabolism
HV128_RS12020	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV128_RS12025	COG1024	Enoyl-CoA hydratase
HV128_RS12030	COG1024	Enoyl-CoA hydratase
HV128_RS12035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV128_RS12040	COG2151	metal-sulfur cluster biosynthetic enzyme
HV128_RS12045	COG3396	Phenylacetate-CoA oxygenase
HV128_RS12050	COG3460	Phenylacetate-CoA oxygenase
HV128_RS12055	COG3396	Phenylacetate-CoA oxygenase
HV128_RS12060	COG2030	dehydratase
HV128_RS12060	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS12080	COG3733	amine oxidase
HV128_RS12085	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV128_RS12090	COG5001	Diguanylate cyclase
HV128_RS12090	COG4251	negative regulation of phosphorylation
HV128_RS12090	COG3706	GGDEF domain
HV128_RS12090	COG2203	Gaf domain
HV128_RS12095	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS12100	COG2207	Transcriptional regulator
HV128_RS12105	COG3784	Protein of unknown function (DUF1318)
HV128_RS12120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV128_RS12145	COG4993	Dehydrogenase
HV128_RS12155	COG0814	amino acid
HV128_RS12180	COG1683	Conserved Protein
HV128_RS12190	COG4221	oxidoreductase activity
HV128_RS12195	COG1802	Transcriptional regulator
HV128_RS12200	COG0589	response to stress
HV128_RS12210	COG0246	Mannitol dehydrogenase
HV128_RS12215	COG0477	Major facilitator Superfamily
HV128_RS12220	COG1063	alcohol dehydrogenase
HV128_RS12225	COG4948	Mandelate Racemase Muconate Lactonizing
HV128_RS12230	COG1742	UPF0060 membrane protein
HV128_RS12240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV128_RS12265	COG0437	4 iron, 4 sulfur cluster binding
HV128_RS12270	COG3302	dmso reductase anchor subunit
HV128_RS12275	COG3381	protein complex oligomerization
HV128_RS12280	COG3141	response to X-ray
HV128_RS12295	COG0583	DNA-binding transcription factor activity
HV128_RS12340	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV128_RS12345	COG1940	carbohydrate kinase activity
HV128_RS12350	COG0583	DNA-binding transcription factor activity
HV128_RS12355	COG2814	Major facilitator Superfamily
HV128_RS12360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV128_RS12375	COG3591	Belongs to the peptidase S1B family
HV128_RS12380	COG2076	Multidrug Resistance protein
HV128_RS12385	COG2076	Multidrug Resistance protein
HV128_RS12390	COG0628	permease
HV128_RS12400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV128_RS12405	COG1403	HNH endonuclease
HV128_RS12410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV128_RS12450	COG4993	Dehydrogenase
HV128_RS12465	COG0667	Aldo Keto reductase
HV128_RS12475	COG2840	Smr protein MutS2
HV128_RS12480	COG0583	DNA-binding transcription factor activity
HV128_RS12490	COG1473	amidohydrolase
HV128_RS12495	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HV128_RS12500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV128_RS12515	COG0668	transmembrane transport
HV128_RS12520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV128_RS12525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV128_RS12535	COG0531	amino acid
HV128_RS12540	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS12545	COG3136	membrane protein required for alginate biosynthesis
HV128_RS12550	COG0745	RESPONSE REGULATOR receiver
HV128_RS12560	COG1278	Cold shock
HV128_RS12570	COG2205	protein histidine kinase activity
HV128_RS12585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV128_RS12585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV128_RS12595	COG5339	Protein conserved in bacteria
HV128_RS12600	COG1609	Transcriptional regulator
HV128_RS12770	COG1783	phage Terminase large subunit
HV128_RS12775	COG3728	DNA packaging
HV128_RS12785	COG3646	Phage regulatory protein
HV128_RS12880	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HV128_RS12970	COG0582	viral genome integration into host DNA
HV128_RS12980	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV128_RS12985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HV128_RS12990	COG0673	inositol 2-dehydrogenase activity
HV128_RS13040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV128_RS13045	COG3104	oligopeptide transport
HV128_RS13050	COG0625	glutathione transferase activity
HV128_RS13055	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV128_RS13060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HV128_RS13065	COG0259	pyridoxamine-phosphate oxidase activity
HV128_RS13070	COG3895	Periplasmic Protein
HV128_RS13075	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HV128_RS13085	COG3706	GGDEF domain
HV128_RS13100	COG1566	PFAM secretion protein HlyD family protein
HV128_RS13105	COG1289	transmembrane transporter activity
HV128_RS13110	COG2032	superoxide dismutase activity
HV128_RS13115	COG4989	oxidoreductase activity
HV128_RS13120	COG3313	Fe-S protein
HV128_RS13125	COG2194	sulfuric ester hydrolase activity
HV128_RS13130	COG1309	transcriptional regulator
HV128_RS13135	COG1902	pentaerythritol trinitrate reductase activity
HV128_RS13140	COG0346	lactoylglutathione lyase activity
HV128_RS13150	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV128_RS13155	COG0791	NLP P60 protein
HV128_RS13165	COG2814	Major facilitator Superfamily
HV128_RS13180	COG0583	DNA-binding transcription factor activity
HV128_RS13185	COG2814	Major facilitator Superfamily
HV128_RS13190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV128_RS13195	COG0307	riboflavin synthase, alpha
HV128_RS13215	COG0071	Belongs to the small heat shock protein (HSP20) family
HV128_RS13225	COG4529	Protein conserved in bacteria
HV128_RS13235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV128_RS13255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV128_RS13265	COG0765	amino acid transport
HV128_RS13270	COG0765	amino acid transport
HV128_RS13280	COG1464	Belongs to the NlpA lipoprotein family
HV128_RS13285	COG2011	ABC-type metal ion transport system permease component
HV128_RS13300	COG0626	cystathionine gamma-synthase activity
HV128_RS13315	COG1376	ErfK ybiS ycfS ynhG family protein
HV128_RS13320	COG2166	iron-sulfur cluster assembly
HV128_RS13325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV128_RS13330	COG0719	Fe-S assembly protein
HV128_RS13335	COG0396	ATPase activity
HV128_RS13340	COG0719	Fe-S assembly protein
HV128_RS13345	COG0316	Belongs to the HesB IscA family
HV128_RS13360	COG0789	Transcriptional regulator
HV128_RS13365	COG2200	EAL domain
HV128_RS13385	COG3383	formate dehydrogenase (NAD+) activity
HV128_RS13395	COG3539	Fimbrial protein
HV128_RS13410	COG3121	Chaperone
HV128_RS13425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV128_RS13435	COG2050	protein possibly involved in aromatic compounds catabolism
HV128_RS13440	COG0277	FAD linked oxidase domain protein
HV128_RS13440	COG0247	lactate metabolic process
HV128_RS13445	COG0628	permease
HV128_RS13455	COG1472	Belongs to the glycosyl hydrolase 3 family
HV128_RS13460	COG2211	Major facilitator Superfamily
HV128_RS13465	COG0574	Belongs to the PEP-utilizing enzyme family
HV128_RS13465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV128_RS13470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HV128_RS13475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV128_RS13480	COG4256	Hemin uptake protein
HV128_RS13490	COG3720	iron ion transport
HV128_RS13495	COG4558	Periplasmic binding protein
HV128_RS13500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV128_RS13510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HV128_RS13520	COG0791	NLP P60 protein
HV128_RS13530	COG0386	Belongs to the glutathione peroxidase family
HV128_RS13540	COG0776	regulation of translation
HV128_RS13545	COG0072	phenylalanine-tRNA ligase activity
HV128_RS13545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV128_RS13550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HV128_RS13595	COG3137	Salt-induced outer membrane protein
HV128_RS13600	COG1105	Belongs to the carbohydrate kinase PfkB family
HV128_RS13610	COG3001	Fructosamine kinase
HV128_RS13620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV128_RS13625	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS13630	COG1988	membrane-bound metal-dependent
HV128_RS13645	COG0753	catalase activity
HV128_RS13650	COG3394	polysaccharide catabolic process
HV128_RS13655	COG1486	melibiose metabolic process
HV128_RS13660	COG2169	Transcriptional regulator
HV128_RS13660	COG1917	Cupin 2, conserved barrel domain protein
HV128_RS13665	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV128_RS13670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV128_RS13675	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV128_RS13680	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV128_RS13690	COG0322	excinuclease ABC activity
HV128_RS13700	COG3678	ATP-independent chaperone mediated protein folding
HV128_RS13710	COG3724	N-succinylarginine dihydrolase activity
HV128_RS13715	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS13720	COG3138	arginine N-succinyltransferase
HV128_RS13730	COG0708	Exodeoxyribonuclease III
HV128_RS13740	COG4134	Bacterial extracellular solute-binding protein
HV128_RS13745	COG4135	transport system, permease component
HV128_RS13750	COG4136	ATPase activity
HV128_RS13755	COG2897	thiosulfate sulfurtransferase activity
HV128_RS13760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV128_RS13765	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV128_RS13770	COG0494	nUDIX hydrolase
HV128_RS13785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV128_RS13790	COG0709	Synthesizes selenophosphate from selenide and ATP
HV128_RS13795	COG0778	Nitroreductase
HV128_RS13800	COG0616	signal peptide processing
HV128_RS13805	COG0252	asparaginase activity
HV128_RS13810	COG1335	isochorismatase
HV128_RS13820	COG3139	Protein of unknown function (DUF1315)
HV128_RS13840	COG3713	MltA-interacting MipA family protein
HV128_RS13845	COG2766	serine protein kinase
HV128_RS13850	COG2718	Belongs to the UPF0229 family
HV128_RS13865	COG2246	polysaccharide biosynthetic process
HV128_RS13870	COG0463	Glycosyl transferase, family 2
HV128_RS13890	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV128_RS13895	COG2211	Major facilitator Superfamily
HV128_RS13905	COG2707	UPF0756 membrane protein
HV128_RS13910	COG2207	Transcriptional regulator
HV128_RS13915	COG2807	transmembrane transport
HV128_RS13920	COG0504	CTP synthase activity
HV128_RS13925	COG3189	MarR family transcriptional regulator
HV128_RS13935	COG3042	response to heat
HV128_RS13940	COG2203	Gaf domain
HV128_RS13940	COG2199	diguanylate cyclase activity
HV128_RS13955	COG2261	transglycosylase associated protein
HV128_RS13965	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV128_RS13975	COG0538	isocitrate dehydrogenase activity
HV128_RS13980	COG1187	pseudouridine synthase activity
HV128_RS13995	COG2915	High frequency lysogenization protein hflD homolog
HV128_RS14000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV128_RS14015	COG2205	protein histidine kinase activity
HV128_RS14020	COG2850	peptidyl-arginine hydroxylation
HV128_RS14025	COG1943	Transposase
HV128_RS14065	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV128_RS14070	COG1136	(ABC) transporter
HV128_RS14075	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV128_RS14080	COG4763	Acyl-transferase
HV128_RS14085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV128_RS14090	COG1388	LysM domain
HV128_RS14090	COG1376	ErfK ybiS ycfS ynhG family protein
HV128_RS14100	COG1309	transcriptional regulator
HV128_RS14105	COG3134	Outer membrane lipoprotein
HV128_RS14110	COG1252	NADH dehydrogenase
HV128_RS14115	COG3150	esterase
HV128_RS14130	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HV128_RS14135	COG5633	Lipoprotein
HV128_RS14140	COG0537	adenosine 5'-monophosphoramidase activity
HV128_RS14145	COG4773	Receptor
HV128_RS14155	COG0084	hydrolase, TatD family'
HV128_RS14160	COG0470	DNA polymerase III
HV128_RS14170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV128_RS14175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV128_RS14180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV128_RS14185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV128_RS14200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HV128_RS14205	COG0416	fatty acid biosynthetic process
HV128_RS14210	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HV128_RS14225	COG0564	pseudouridine synthase activity
HV128_RS14230	COG1530	ribonuclease E activity
HV128_RS14235	COG0583	DNA-binding transcription factor activity
HV128_RS14240	COG2814	Major facilitator Superfamily
HV128_RS14250	COG1256	bacterial-type flagellum assembly
HV128_RS14270	COG4786	Flagellar basal body rod
HV128_RS14280	COG1749	Flagellar hook protein flgE
HV128_RS14290	COG1558	bacterial-type flagellum-dependent cell motility
HV128_RS14325	COG3132	Protein of unknown function, DUF480
HV128_RS14330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV128_RS14335	COG0477	Major facilitator Superfamily
HV128_RS14345	COG0418	dihydroorotase activity
HV128_RS14370	COG3038	cytochrome b561
HV128_RS14375	COG2353	YceI-like domain
HV128_RS14385	COG1560	Kdo2-lipid A biosynthetic process
HV128_RS14400	COG5645	(Lipo)protein
HV128_RS14405	COG2943	transferase activity, transferring hexosyl groups
HV128_RS14420	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV128_RS14470	COG3381	protein complex oligomerization
HV128_RS14475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HV128_RS14480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV128_RS14495	COG0583	DNA-binding transcription factor activity
HV128_RS14505	COG1335	isochorismatase
HV128_RS14515	COG1702	phosphate starvation-inducible protein PhoH
HV128_RS14525	COG2822	iron ion transport
HV128_RS14535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV128_RS14545	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV128_RS14550	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV128_RS14550	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV128_RS14550	COG0506	proline dehydrogenase activity
HV128_RS14560	COG1309	transcriptional regulator
HV128_RS14565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV128_RS14570	COG1335	isochorismatase
HV128_RS14575	COG0251	oxidation-reduction process
HV128_RS14580	COG2267	carboxylic ester hydrolase activity
HV128_RS14585	COG0778	Nitroreductase
HV128_RS14590	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV128_RS14595	COG2233	PERMEase
HV128_RS14615	COG3729	General stress protein
HV128_RS14635	COG1733	regulation of RNA biosynthetic process
HV128_RS14640	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS14645	COG0586	Pfam SNARE associated Golgi protein
HV128_RS14650	COG2239	Acts as a magnesium transporter
HV128_RS14665	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV128_RS14665	COG3264	Mechanosensitive ion channel
HV128_RS14675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV128_RS14680	COG1120	ATPase activity
HV128_RS14695	COG0670	Belongs to the BI1 family
HV128_RS14705	COG1254	Belongs to the acylphosphatase family
HV128_RS14710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HV128_RS14720	COG1832	CoA-binding protein
HV128_RS14725	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HV128_RS14730	COG1803	Methylglyoxal synthase
HV128_RS14735	COG0210	DNA helicase
HV128_RS14740	COG3304	Inner membrane component domain
HV128_RS14745	COG1289	transmembrane transporter activity
HV128_RS14750	COG3070	regulator of competence-specific genes
HV128_RS14755	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HV128_RS14765	COG3120	sequence-specific DNA binding
HV128_RS14770	COG1067	ATP-dependent peptidase activity
HV128_RS14780	COG3130	regulation of translation
HV128_RS14785	COG3009	Protein conserved in bacteria
HV128_RS14790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV128_RS14790	COG3008	intermembrane lipid transfer
HV128_RS14795	COG2995	paraquat-inducible protein a
HV128_RS14800	COG0488	(ABC) transporter
HV128_RS14805	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HV128_RS14805	COG0116	Belongs to the methyltransferase superfamily
HV128_RS14810	COG0633	Ferredoxin
HV128_RS14810	COG3217	Mosc domain protein beta barrel domain protein
HV128_RS14820	COG0167	dihydroorotate dehydrogenase activity
HV128_RS14825	COG0431	NADPH-dependent FMN reductase
HV128_RS14830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV128_RS14835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV128_RS14840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV128_RS14850	COG0308	aminopeptidase N
HV128_RS14855	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HV128_RS14860	COG0017	Asparaginyl-tRNA synthetase
HV128_RS14870	COG1448	Aminotransferase
HV128_RS14875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV128_RS14880	COG3108	Peptidase M15
HV128_RS14885	COG2989	Protein conserved in bacteria
HV128_RS14890	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV128_RS14895	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV128_RS14905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV128_RS14910	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV128_RS14915	COG3173	Aminoglycoside phosphotransferase
HV128_RS14920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HV128_RS14925	COG2835	tetraacyldisaccharide 4'-kinase activity
HV128_RS14930	COG3214	Protein conserved in bacteria
HV128_RS14940	COG1132	(ABC) transporter
HV128_RS14945	COG2333	competence protein COMEC
HV128_RS14945	COG0658	competence protein
HV128_RS14950	COG0776	regulation of translation
HV128_RS14955	COG0539	negative regulation of cytoplasmic translation
HV128_RS14960	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HV128_RS14965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HV128_RS14970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HV128_RS14975	COG2323	membrane
HV128_RS14980	COG1944	ATP diphosphatase activity
HV128_RS14985	COG2116	formate transmembrane transporter activity
HV128_RS14990	COG1882	Formate acetyltransferase
HV128_RS14995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV128_RS15005	COG0477	Major facilitator Superfamily
HV128_RS15010	COG3302	dmso reductase anchor subunit
HV128_RS15015	COG0437	4 iron, 4 sulfur cluster binding
HV128_RS15020	COG0243	molybdopterin cofactor binding
HV128_RS15025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HV128_RS15030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV128_RS15035	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HV128_RS15040	COG1178	ABC-type Fe3 transport system permease component
HV128_RS15040	COG1674	ftsk spoiiie
HV128_RS15050	COG0492	ferredoxin-NADP+ reductase activity
HV128_RS15055	COG4988	ABC transporter
HV128_RS15060	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV128_RS15065	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HV128_RS15070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV128_RS15075	COG5642	Protein of unknown function (DUF2384)
HV128_RS15080	COG5654	RES domain protein
HV128_RS15105	COG1203	CRISPR-associated helicase, Cas3
HV128_RS15110	COG1518	maintenance of DNA repeat elements
HV128_RS15120	COG0542	response to heat
HV128_RS15125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HV128_RS15130	COG1278	Cold shock
HV128_RS15140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV128_RS15145	COG2990	Protein conserved in bacteria
HV128_RS15150	COG3593	DNA synthesis involved in DNA repair
HV128_RS15160	COG2431	L-lysine efflux transmembrane transporter activity
HV128_RS15165	COG1151	hydroxylamine reductase activity
HV128_RS15170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV128_RS15175	COG0028	Belongs to the TPP enzyme family
HV128_RS15180	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV128_RS15185	COG0702	epimerase
HV128_RS15190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV128_RS15195	COG3397	chitin binding
HV128_RS15210	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HV128_RS15235	COG2165	general secretion pathway protein
HV128_RS15245	COG2165	general secretion pathway protein
HV128_RS15250	COG1459	type II secretion system
HV128_RS15255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV128_RS15260	COG1450	Type ii and iii secretion system protein
HV128_RS15265	COG3031	protein transport across the cell outer membrane
HV128_RS15285	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV128_RS15290	COG0393	Putative heavy-metal-binding
HV128_RS15300	COG1126	abc transporter atp-binding protein
HV128_RS15305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV128_RS15310	COG4215	(ABC) transporter
HV128_RS15315	COG4160	amino acid transport
HV128_RS15320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV128_RS15325	COG5002	protein histidine kinase activity
HV128_RS15330	COG0745	RESPONSE REGULATOR receiver
HV128_RS15335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV128_RS15345	COG1177	transmembrane transport
HV128_RS15350	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV128_RS15355	COG3842	ATPase activity
HV128_RS15360	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV128_RS15375	COG0778	Nitroreductase
HV128_RS15395	COG0640	Transcriptional regulator
HV128_RS15400	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV128_RS15405	COG1393	Belongs to the ArsC family
HV128_RS15410	COG3226	Transcriptional regulator
HV128_RS15415	COG0738	Major facilitator superfamily
HV128_RS15420	COG0561	phosphatase activity
HV128_RS15425	COG2814	Major facilitator Superfamily
HV128_RS15435	COG0671	phosphoesterase, PA-phosphatase related
HV128_RS15440	COG1349	DNA-binding transcription factor activity
HV128_RS15445	COG1686	Belongs to the peptidase S11 family
HV128_RS15450	COG0625	glutathione transferase activity
HV128_RS15455	COG2133	pyrroloquinoline quinone binding
HV128_RS15490	COG1446	asparaginase
HV128_RS15495	COG0303	'Molybdopterin
HV128_RS15505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV128_RS15510	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV128_RS15515	COG1882	Formate acetyltransferase
HV128_RS15520	COG0561	phosphatase activity
HV128_RS15530	COG1609	Transcriptional regulator
HV128_RS15535	COG2271	Major facilitator Superfamily
HV128_RS15545	COG0488	(ABC) transporter
HV128_RS15550	COG1376	ErfK ybiS ycfS ynhG family protein
HV128_RS15555	COG2188	Transcriptional regulator
HV128_RS15560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV128_RS15565	COG2723	6-phospho-beta-galactosidase activity
HV128_RS15570	COG0667	Aldo Keto reductase
HV128_RS15580	COG2814	Major facilitator Superfamily
HV128_RS15585	COG1566	PFAM secretion protein HlyD family protein
HV128_RS15590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV128_RS15595	COG1321	iron dependent repressor
HV128_RS15605	COG2194	sulfuric ester hydrolase activity
HV128_RS15610	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV128_RS15620	COG0783	Belongs to the Dps family
HV128_RS15625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV128_RS15630	COG0765	amino acid transport
HV128_RS15635	COG1126	abc transporter atp-binding protein
HV128_RS15640	COG0668	transmembrane transport
HV128_RS15645	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HV128_RS15655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV128_RS15665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV128_RS15670	COG3539	Fimbrial protein
HV128_RS15700	COG0513	Belongs to the DEAD box helicase family
HV128_RS15705	COG1309	transcriptional regulator
HV128_RS15710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV128_RS15715	COG1131	(ABC) transporter
HV128_RS15720	COG0842	Transport permease protein
HV128_RS15725	COG0842	Transport permease protein
HV128_RS15735	COG3568	Endonuclease Exonuclease Phosphatase
HV128_RS15740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV128_RS15745	COG0392	lysyltransferase activity
HV128_RS15750	COG0670	Belongs to the BI1 family
HV128_RS15755	COG0314	molybdopterin synthase activity
HV128_RS15760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV128_RS15765	COG0315	cyclic pyranopterin monophosphate synthase activity
HV128_RS15770	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV128_RS15800	COG2226	methyltransferase
HV128_RS15805	COG0156	8-amino-7-oxononanoate synthase activity
HV128_RS15810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HV128_RS15815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HV128_RS15820	COG1881	PFAM PEBP family protein
HV128_RS15825	COG2986	histidine ammonia-lyase
HV128_RS15830	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HV128_RS15840	COG0010	Belongs to the arginase family
HV128_RS15850	COG4677	pectinesterase activity
HV128_RS15855	COG2706	6-phosphogluconolactonase activity
HV128_RS15860	COG0561	phosphatase activity
HV128_RS15870	COG4149	molybdate abc transporter
HV128_RS15875	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV128_RS15885	COG3585	molybdate ion transport
HV128_RS15885	COG2005	Transcriptional regulator
HV128_RS15890	COG1119	ATPase activity
HV128_RS15895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV128_RS15900	COG1085	galactose-1-phosphate uridylyltransferase
HV128_RS15905	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HV128_RS15910	COG2017	converts alpha-aldose to the beta-anomer
HV128_RS15920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV128_RS15930	COG1230	cation diffusion facilitator family transporter
HV128_RS15935	COG3201	nicotinamide mononucleotide transporter
HV128_RS15970	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV128_RS15975	COG2885	chlorophyll binding
HV128_RS15980	COG0823	Involved in the tonB-independent uptake of proteins
HV128_RS15985	COG3064	Membrane
HV128_RS15990	COG0848	biopolymer transport protein
HV128_RS15995	COG0811	peptide transport
HV128_RS16000	COG0824	Thioesterase
HV128_RS16005	COG3790	cyd operon protein YbgE
HV128_RS16010	COG4890	Cyd operon protein YbgT
HV128_RS16015	COG1294	oxidase, subunit
HV128_RS16020	COG1271	oxidase subunit
HV128_RS16025	COG0383	alpha-mannosidase activity
HV128_RS16030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV128_RS16030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV128_RS16030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS16035	COG2188	Transcriptional regulator
HV128_RS16040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV128_RS16045	COG0045	succinate-CoA ligase (ADP-forming) activity
HV128_RS16050	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV128_RS16055	COG0567	Dehydrogenase, E1 component
HV128_RS16060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV128_RS16065	COG1053	succinate dehydrogenase
HV128_RS16070	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV128_RS16075	COG2009	succinate dehydrogenase
HV128_RS16080	COG0372	Belongs to the citrate synthase family
HV128_RS16085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HV128_RS16095	COG1984	allophanate hydrolase subunit 2
HV128_RS16100	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV128_RS16105	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HV128_RS16125	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HV128_RS16130	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HV128_RS16135	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HV128_RS16140	COG2205	protein histidine kinase activity
HV128_RS16145	COG0745	RESPONSE REGULATOR receiver
HV128_RS16155	COG1982	Orn Lys Arg decarboxylase major
HV128_RS16160	COG0531	amino acid
HV128_RS16165	COG0033	Phosphoglucomutase
HV128_RS16170	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV128_RS16175	COG0596	Alpha beta hydrolase
HV128_RS16195	COG0735	belongs to the Fur family
HV128_RS16215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV128_RS16215	COG2190	(PTS) system
HV128_RS16215	COG1263	PTS System
HV128_RS16225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV128_RS16230	COG1846	Transcriptional regulator
HV128_RS16230	COG1940	carbohydrate kinase activity
HV128_RS16235	COG0647	UMP catabolic process
HV128_RS16240	COG0367	asparagine synthase
HV128_RS16280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV128_RS16285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HV128_RS16290	COG1702	phosphate starvation-inducible protein PhoH
HV128_RS16295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV128_RS16315	COG0765	amino acid transport
HV128_RS16320	COG0765	amino acid transport
HV128_RS16325	COG1126	abc transporter atp-binding protein
HV128_RS16330	COG1957	nucleoside hydrolase
HV128_RS16335	COG2888	peptidyl-tyrosine sulfation
HV128_RS16350	COG1466	dna polymerase III delta subunit
HV128_RS16360	COG0799	negative regulation of ribosome biogenesis
HV128_RS16370	COG0768	penicillin binding
HV128_RS16375	COG0772	Belongs to the SEDS family
HV128_RS16380	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV128_RS16385	COG1686	Belongs to the peptidase S11 family
HV128_RS16395	COG0321	lipoyl(octanoyl) transferase activity
HV128_RS16400	COG0583	DNA-binding transcription factor activity
HV128_RS16405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HV128_RS16410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HV128_RS16415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV128_RS16440	COG3069	C4-dicarboxylate transmembrane transporter activity
HV128_RS16445	COG3719	Belongs to the RNase T2 family
HV128_RS16450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV128_RS16455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV128_RS16460	COG0006	proline dipeptidase activity
HV128_RS16465	COG1363	Peptidase, m42
HV128_RS16470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS16470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS16470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV128_RS16475	COG2207	Transcriptional regulator
HV128_RS16485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV128_RS16490	COG1063	alcohol dehydrogenase
HV128_RS16510	COG0243	molybdopterin cofactor binding
HV128_RS16530	COG0583	DNA-binding transcription factor activity
HV128_RS16535	COG3969	phosphoadenosine phosphosulfate
HV128_RS16540	COG1475	DNA binding
HV128_RS16545	COG0436	Aminotransferase
HV128_RS16550	COG0235	Class ii aldolase
HV128_RS16555	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HV128_RS16570	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HV128_RS16585	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV128_RS16590	COG1129	ABC transporter
HV128_RS16595	COG0371	Dehydrogenase
HV128_RS16600	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS16615	COG2879	small protein
HV128_RS16620	COG1966	Carbon starvation protein
HV128_RS16625	COG2050	protein possibly involved in aromatic compounds catabolism
HV128_RS16630	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS16635	COG1535	isochorismatase
HV128_RS16635	COG3433	isochorismatase activity
HV128_RS16640	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV128_RS16645	COG1169	isochorismate synthase
HV128_RS16650	COG4592	Periplasmic binding protein
HV128_RS16660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV128_RS16665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV128_RS16670	COG1120	ATPase activity
HV128_RS16675	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV128_RS16675	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV128_RS16680	COG3251	PFAM MbtH domain protein
HV128_RS16685	COG2382	esterase
HV128_RS16690	COG4771	TonB-dependent receptor
HV128_RS16695	COG2977	Belongs to the P-Pant transferase superfamily
HV128_RS16700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV128_RS16705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV128_RS16710	COG1121	(ABC) transporter
HV128_RS16725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV128_RS16755	COG0601	transmembrane transport
HV128_RS16765	COG0444	Belongs to the ABC transporter superfamily
HV128_RS16770	COG4608	Belongs to the ABC transporter superfamily
HV128_RS16825	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HV128_RS16855	COG4774	siderophore transport
HV128_RS16875	COG2315	Protein conserved in bacteria
HV128_RS16880	COG0778	Nitroreductase
HV128_RS16900	COG0477	Major facilitator Superfamily
HV128_RS16905	COG0668	transmembrane transport
HV128_RS16910	COG1609	Transcriptional regulator
HV128_RS16925	COG2211	Major facilitator Superfamily
HV128_RS16930	COG1113	amino acid transport
HV128_RS16955	COG2246	polysaccharide biosynthetic process
HV128_RS16960	COG0463	Glycosyl transferase, family 2
HV128_RS17070	COG1783	phage Terminase large subunit
HV128_RS17075	COG3728	DNA packaging
HV128_RS17085	COG3646	Phage regulatory protein
HV128_RS17115	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HV128_RS17155	COG0305	Participates in initiation and elongation during chromosome replication
HV128_RS17225	COG3723	Recombinational DNA repair protein, rece pathway
HV128_RS17245	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV128_RS17340	COG2501	S4 domain
HV128_RS17345	COG1263	PTS System
HV128_RS17345	COG2190	(PTS) system
HV128_RS17345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV128_RS17350	COG1609	Transcriptional regulator
HV128_RS17365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV128_RS17370	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV128_RS17375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV128_RS17380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV128_RS17390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV128_RS17395	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV128_RS17400	COG4181	ATPase activity
HV128_RS17405	COG2755	lipolytic protein G-D-S-L family
HV128_RS17410	COG0300	oxidoreductase activity
HV128_RS17415	COG3118	belongs to the thioredoxin family
HV128_RS17420	COG0390	transport system, permease component
HV128_RS17425	COG4619	ABC transporter
HV128_RS17435	COG0330	HflC and HflK could
HV128_RS17440	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV128_RS17450	COG2217	Heavy metal translocating P-type atpase
HV128_RS17455	COG3735	TraB family
HV128_RS17460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV128_RS17465	COG0737	Belongs to the 5'-nucleotidase family
HV128_RS17470	COG2223	nitrite transmembrane transporter activity
HV128_RS17475	COG4651	solute:proton antiporter activity
HV128_RS17475	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV128_RS17480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV128_RS17485	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HV128_RS17495	COG0326	Molecular chaperone. Has ATPase activity
HV128_RS17500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HV128_RS17505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HV128_RS17515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HV128_RS17520	COG2832	Protein of unknown function (DUF454)
HV128_RS17525	COG3923	Primosomal replication protein n
HV128_RS17535	COG3264	Mechanosensitive ion channel
HV128_RS17535	COG1196	nuclear chromosome segregation
HV128_RS17540	COG1309	transcriptional regulator
HV128_RS17545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV128_RS17550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV128_RS17565	COG0110	maltose O-acetyltransferase activity
HV128_RS17585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HV128_RS17595	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV128_RS17615	COG1609	Transcriptional regulator
HV128_RS17620	COG2364	Membrane
HV128_RS17625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV128_RS17645	COG3695	enzyme binding
HV128_RS17650	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV128_RS17655	COG1946	Acyl-CoA thioesterase
HV128_RS17660	COG0004	ammonium transporteR
HV128_RS17665	COG0347	Belongs to the P(II) protein family
HV128_RS17670	COG1132	(ABC) transporter
HV128_RS17675	COG1132	(ABC) transporter
HV128_RS17680	COG1522	sequence-specific DNA binding
HV128_RS17690	COG0561	phosphatase activity
HV128_RS17695	COG4533	DNA binding
HV128_RS17700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HV128_RS17710	COG3657	addiction module killer protein
HV128_RS17715	COG0824	Thioesterase
HV128_RS17720	COG1555	photosystem II stabilization
HV128_RS17725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV128_RS17730	COG0776	regulation of translation
HV128_RS17735	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV128_RS17750	COG0544	peptidyl-prolyl cis-trans isomerase activity
HV128_RS17755	COG0271	Belongs to the BolA IbaG family
HV128_RS17760	COG3056	Lipoprotein
HV128_RS17765	COG2223	nitrite transmembrane transporter activity
HV128_RS17770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV128_RS17775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV128_RS17780	COG1845	cytochrome c oxidase, subunit III
HV128_RS17785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV128_RS17790	COG0109	protoheme IX farnesyltransferase activity
HV128_RS17810	COG1129	ABC transporter
HV128_RS17815	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV128_RS17835	COG0235	Class ii aldolase
HV128_RS17840	COG2814	Major facilitator Superfamily
HV128_RS17850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HV128_RS17855	COG0693	protein deglycase activity
HV128_RS17870	COG0142	geranyltranstransferase activity
HV128_RS17875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV128_RS17880	COG0667	Aldo Keto reductase
HV128_RS17885	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV128_RS17890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HV128_RS17895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HV128_RS17900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV128_RS17900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV128_RS17905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HV128_RS17910	COG4238	major outer membrane lipoprotein
HV128_RS17930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV128_RS17935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV128_RS17940	COG1862	Preprotein translocase
HV128_RS17955	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HV128_RS17960	COG0450	alkyl hydroperoxide reductase
HV128_RS17975	COG0366	Alpha amylase catalytic
HV128_RS17990	COG5002	protein histidine kinase activity
HV128_RS18000	COG0420	3'-5' exonuclease activity
HV128_RS18005	COG0419	ATPase involved in DNA repair
HV128_RS18010	COG1940	carbohydrate kinase activity
HV128_RS18020	COG3123	guanosine phosphorylase activity
HV128_RS18025	COG4126	flavin adenine dinucleotide binding
HV128_RS18035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV128_RS18040	COG1671	Belongs to the UPF0178 family
HV128_RS18045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV128_RS18050	COG3706	GGDEF domain
HV128_RS18075	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV128_RS18095	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV128_RS18100	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV128_RS18115	COG0113	porphobilinogen synthase activity
HV128_RS18125	COG2175	clavaminate synthase activity
HV128_RS18130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV128_RS18135	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV128_RS18140	COG4521	taurine ABC transporter
HV128_RS18145	COG2040	homocysteine
HV128_RS18150	COG0833	amino acid
HV128_RS18155	COG0628	permease
HV128_RS18170	COG3300	MHYT domain
HV128_RS18170	COG5001	Diguanylate cyclase
HV128_RS18180	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV128_RS18200	COG2003	Belongs to the UPF0758 family
HV128_RS18225	COG2378	regulation of single-species biofilm formation
HV128_RS18260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HV128_RS18265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV128_RS18270	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV128_RS18290	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV128_RS18295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV128_RS18300	COG2991	Protein conserved in bacteria
HV128_RS18315	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV128_RS18320	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV128_RS18335	COG3034	peptidoglycan biosynthetic process
HV128_RS18340	COG0121	glutamine amidotransferase
HV128_RS18355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV128_RS18375	COG2226	methyltransferase
HV128_RS18380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV128_RS18385	COG0741	lytic transglycosylase activity
HV128_RS18385	COG1388	LysM domain
HV128_RS18390	COG2226	methyltransferase
HV128_RS18395	COG3021	interspecies interaction between organisms
HV128_RS18400	COG2814	Major facilitator Superfamily
HV128_RS18405	COG0583	DNA-binding transcription factor activity
HV128_RS18445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV128_RS18455	COG2011	ABC-type metal ion transport system permease component
HV128_RS18460	COG1464	Belongs to the NlpA lipoprotein family
HV128_RS18470	COG1720	tRNA m6t6A37 methyltransferase activity
HV128_RS18480	COG3015	lipoprotein NlpE involved in copper resistance
HV128_RS18485	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV128_RS18500	COG4568	rho-dependent transcription termination
HV128_RS18505	COG0037	tRNA processing
HV128_RS18510	COG0346	lactoylglutathione lyase activity
HV128_RS18520	COG0825	malonyl-CoA metabolic process
HV128_RS18530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HV128_RS18535	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV128_RS18540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV128_RS18545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HV128_RS18560	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV128_RS18565	COG0750	zinc metalloprotease
HV128_RS18570	COG0575	Belongs to the CDS family
HV128_RS18580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV128_RS18625	COG3835	regulator
HV128_RS18635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HV128_RS18640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV128_RS18650	COG2860	membrane
HV128_RS18655	COG0316	Belongs to the HesB IscA family
HV128_RS18665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HV128_RS18670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV128_RS18675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV128_RS18680	COG1120	ATPase activity
HV128_RS18685	COG4774	siderophore transport
HV128_RS18690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV128_RS18695	COG1643	Atp-dependent helicase
HV128_RS18700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV128_RS18705	COG1489	DNA binding
HV128_RS18715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV128_RS18720	COG0617	tRNA 3'-terminal CCA addition
HV128_RS18725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV128_RS18735	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HV128_RS18740	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HV128_RS18750	COG3121	Chaperone
HV128_RS18755	COG3188	usher protein
HV128_RS18760	COG3539	Fimbrial protein
HV128_RS18780	COG0726	polysaccharide deacetylase
HV128_RS18785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS18790	COG0842	Transport permease protein
HV128_RS18795	COG1131	(ABC) transporter
HV128_RS18800	COG0288	reversible hydration of carbon dioxide
HV128_RS18810	COG4993	Dehydrogenase
HV128_RS18825	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HV128_RS18845	COG3064	Membrane
HV128_RS18855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV128_RS18860	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV128_RS18865	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV128_RS18870	COG2186	Transcriptional regulator
HV128_RS18875	COG1113	amino acid transport
HV128_RS18880	COG2211	Major facilitator Superfamily
HV128_RS18885	COG3940	Belongs to the glycosyl hydrolase 43 family
HV128_RS18890	COG3725	Membrane protein required for beta-lactamase induction
HV128_RS18895	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV128_RS18905	COG4969	Belongs to the N-Me-Phe pilin family
HV128_RS18910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV128_RS18915	COG1459	type II secretion system
HV128_RS18920	COG0516	GMP reductase activity
HV128_RS18930	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HV128_RS18935	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HV128_RS18940	COG0494	nUDIX hydrolase
HV128_RS18945	COG0653	protein targeting
HV128_RS18955	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HV128_RS18960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV128_RS18965	COG0849	cell division
HV128_RS18975	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV128_RS18990	COG0772	Belongs to the SEDS family
HV128_RS19000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV128_RS19005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV128_RS19010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV128_RS19015	COG0768	penicillin binding
HV128_RS19030	COG2001	Belongs to the MraZ family
HV128_RS19035	COG1609	Transcriptional regulator
HV128_RS19045	COG0028	Belongs to the TPP enzyme family
HV128_RS19060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV128_RS19085	COG2814	Major facilitator Superfamily
HV128_RS19105	COG1178	ABC-type Fe3 transport system permease component
HV128_RS19115	COG0586	Pfam SNARE associated Golgi protein
HV128_RS19125	COG1069	ribulokinase activity
HV128_RS19130	COG2160	L-arabinose isomerase activity
HV128_RS19135	COG0235	Class ii aldolase
HV128_RS19140	COG0417	DNA replication proofreading
HV128_RS19145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HV128_RS19150	COG0564	pseudouridine synthase activity
HV128_RS19155	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV128_RS19160	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV128_RS19165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV128_RS19170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HV128_RS19180	COG2967	ApaG domain
HV128_RS19185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV128_RS19195	COG0475	glutathione-regulated potassium exporter activity
HV128_RS19195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV128_RS19220	COG0505	Belongs to the CarA family
HV128_RS19230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HV128_RS19235	COG1047	Peptidyl-prolyl cis-trans
HV128_RS19250	COG0196	riboflavin kinase activity
HV128_RS19255	COG0268	Binds directly to 16S ribosomal RNA
HV128_RS19260	COG0583	DNA-binding transcription factor activity
HV128_RS19265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV128_RS19275	COG0443	Heat shock 70 kDa protein
HV128_RS19280	COG1584	GPR1 FUN34 yaaH family protein
HV128_RS19285	COG0477	Major facilitator Superfamily
HV128_RS19290	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV128_RS19300	COG1115	amino acid carrier protein
HV128_RS19315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV128_RS19325	COG0460	homoserine dehydrogenase
HV128_RS19325	COG0527	aspartate kinase activity
HV128_RS19335	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV128_RS19345	COG0745	RESPONSE REGULATOR receiver
HV128_RS19350	COG3045	CreA protein
HV128_RS19355	COG2207	Transcriptional regulator
HV128_RS19355	COG3708	Transcriptional regulator
HV128_RS19360	COG0406	alpha-ribazole phosphatase activity
HV128_RS19365	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HV128_RS19370	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HV128_RS19375	COG0741	lytic transglycosylase activity
HV128_RS19380	COG0488	(ABC) transporter
HV128_RS19405	COG0560	Phosphoserine phosphatase
HV128_RS19410	COG3726	membrane protein affecting hemolysin expression
HV128_RS19435	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HV128_RS19445	COG1328	CTP reductase activity
HV128_RS19450	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV128_RS19455	COG0084	hydrolase, TatD family'
HV128_RS19460	COG4667	esterase of the alpha-beta hydrolase superfamily
HV128_RS19465	COG5487	UPF0391 membrane protein
HV128_RS19470	COG2823	Periplasmic or secreted lipoprotein
HV128_RS19475	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HV128_RS19480	COG1011	Hydrolase
HV128_RS19485	COG0456	acetyltransferase
HV128_RS19490	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV128_RS19495	COG2813	Specifically methylates the guanine in position
HV128_RS19520	COG3706	GGDEF domain
HV128_RS19525	COG4114	ferric iron reductase
HV128_RS19530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV128_RS19530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV128_RS19535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV128_RS19540	COG2197	response regulator
HV128_RS19545	COG2197	response regulator
HV128_RS19550	COG2966	Psort location CytoplasmicMembrane, score
HV128_RS19555	COG3610	response to peptide
HV128_RS19560	COG1846	Transcriptional regulator
HV128_RS19565	COG1764	response to oxidative stress
HV128_RS19575	COG1484	DNA-dependent DNA replication
HV128_RS19595	COG0840	transmembrane signaling receptor activity
HV128_RS19600	COG1846	Transcriptional regulator
HV128_RS19605	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV128_RS19610	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS19615	COG3384	dioxygenase
HV128_RS19625	COG3971	2-oxopent-4-enoate hydratase activity
HV128_RS19645	COG2368	4-hydroxyphenylacetate
HV128_RS19650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV128_RS19655	COG1349	DNA-binding transcription factor activity
HV128_RS19660	COG1966	Carbon starvation protein
HV128_RS19665	COG2879	small protein
HV128_RS19670	COG0523	cobalamin synthesis protein
HV128_RS19675	COG3307	-O-antigen
HV128_RS19695	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS19710	COG2733	membrane
HV128_RS19720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV128_RS19730	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV128_RS19745	COG5457	Domain of unknown function (DUF1127)
HV128_RS19750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV128_RS19755	COG2850	peptidyl-arginine hydroxylation
HV128_RS19760	COG0740	serine-type endopeptidase activity
HV128_RS19765	COG4566	intracellular signal transduction
HV128_RS19770	COG4191	Histidine kinase
HV128_RS19775	COG2204	response regulator
HV128_RS19790	COG1335	isochorismatase
HV128_RS19815	COG1401	restriction endodeoxyribonuclease activity
HV128_RS19825	COG2211	Major facilitator Superfamily
HV128_RS19835	COG1609	Transcriptional regulator
HV128_RS19850	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV128_RS19875	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV128_RS19880	COG1414	Transcriptional regulator
HV128_RS19885	COG3507	Belongs to the glycosyl hydrolase 43 family
HV128_RS19890	COG2211	Major facilitator Superfamily
HV128_RS19895	COG0129	dihydroxy-acid dehydratase activity
HV128_RS19900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV128_RS19905	COG2731	YhcH YjgK YiaL family protein
HV128_RS19910	COG2235	arginine
HV128_RS19925	COG1288	antiporter activity
HV128_RS19930	COG1438	arginine binding
HV128_RS19945	COG0540	Belongs to the ATCase OTCase family
HV128_RS19955	COG0251	oxidation-reduction process
HV128_RS19960	COG3397	chitin binding
HV128_RS19965	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HV128_RS19975	COG1609	Transcriptional regulator
HV128_RS19980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV128_RS19980	COG1263	PTS System
HV128_RS19985	COG0366	Alpha amylase catalytic
HV128_RS19995	COG0602	queuosine metabolic process
HV128_RS20000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS20000	COG3711	transcriptional antiterminator
HV128_RS20005	COG2706	6-phosphogluconolactonase activity
HV128_RS20020	COG3964	amidohydrolase
HV128_RS20060	COG0312	modulator of DNA gyrase
HV128_RS20065	COG3028	Belongs to the UPF0307 family
HV128_RS20070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV128_RS20085	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV128_RS20090	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV128_RS20095	COG1129	ABC transporter
HV128_RS20100	COG1879	ABC-type sugar transport system periplasmic component
HV128_RS20110	COG2105	PFAM AIG2 family protein
HV128_RS20115	COG2911	Protein conserved in bacteria
HV128_RS20120	COG0729	surface antigen
HV128_RS20125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV128_RS20130	COG1253	flavin adenine dinucleotide binding
HV128_RS20140	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV128_RS20145	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV128_RS20155	COG1733	regulation of RNA biosynthetic process
HV128_RS20160	COG0702	epimerase
HV128_RS20170	COG0697	spore germination
HV128_RS20175	COG0840	transmembrane signaling receptor activity
HV128_RS20185	COG1113	amino acid transport
HV128_RS20190	COG0545	Peptidyl-prolyl cis-trans isomerase
HV128_RS20195	COG3061	Opacity-associated protein A
HV128_RS20200	COG0697	spore germination
HV128_RS20205	COG0359	binds to the 23S rRNA
HV128_RS20210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV128_RS20215	COG2965	DNA replication, synthesis of RNA primer
HV128_RS20255	COG3037	sugar-specific permease SgaT UlaA
HV128_RS20270	COG1073	alpha beta
HV128_RS20275	COG3650	response to hydrogen peroxide
HV128_RS20290	COG1960	acyl-CoA dehydrogenase activity
HV128_RS20295	COG0477	Major facilitator Superfamily
HV128_RS20300	COG0754	glutathionylspermidine amidase activity
HV128_RS20305	COG5463	Belongs to the UPF0441 family
HV128_RS20310	COG3766	membrane
HV128_RS20325	COG1842	Phage shock protein A
HV128_RS20330	COG3789	protein conserved in bacteria
HV128_RS20335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV128_RS20340	COG0557	exoribonuclease II activity
HV128_RS20345	COG1959	2 iron, 2 sulfur cluster binding
HV128_RS20355	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV128_RS20360	COG0330	HflC and HflK could
HV128_RS20365	COG0330	HflC and HflK could
HV128_RS20370	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV128_RS20375	COG1923	regulation of RNA biosynthetic process
HV128_RS20380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HV128_RS20385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HV128_RS20395	COG0802	atpase or kinase
HV128_RS20400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV128_RS20400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV128_RS20405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV128_RS20440	COG3264	Mechanosensitive ion channel
HV128_RS20440	COG1511	domain protein
HV128_RS20450	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HV128_RS20455	COG1053	succinate dehydrogenase
HV128_RS20460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV128_RS20465	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HV128_RS20475	COG0583	DNA-binding transcription factor activity
HV128_RS20500	COG5510	response to toxic substance
HV128_RS20525	COG3366	ferrous iron transmembrane transporter activity
HV128_RS20530	COG0700	Nucleoside recognition
HV128_RS20535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV128_RS20540	COG0459	protein refolding
HV128_RS20550	COG0531	amino acid
HV128_RS20555	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV128_RS20560	COG1027	Aspartate ammonia-lyase
HV128_RS20565	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV128_RS20580	COG1309	transcriptional regulator
HV128_RS20600	COG3647	Membrane
HV128_RS20625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV128_RS20635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV128_RS20640	COG0009	L-threonylcarbamoyladenylate synthase
HV128_RS20645	COG0551	DNA topoisomerase type I activity
HV128_RS20650	COG2922	Belongs to the Smg family
HV128_RS20660	COG0242	peptide deformylase activity
HV128_RS20665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HV128_RS20670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HV128_RS20670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HV128_RS20680	COG1970	mechanosensitive ion channel activity
HV128_RS20685	COG3036	rescue of stalled ribosome
HV128_RS20690	COG0789	Transcriptional regulator
HV128_RS20705	COG0202	RNA polymerase activity
HV128_RS20715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV128_RS20730	COG0201	protein transport
HV128_RS20740	COG1841	ribosomal large subunit assembly
HV128_RS20755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HV128_RS20760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HV128_RS20790	COG0255	Belongs to the universal ribosomal protein uL29 family
HV128_RS20795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HV128_RS20835	COG0051	transcription antitermination factor activity, RNA binding
HV128_RS20875	COG2168	tRNA wobble position uridine thiolation
HV128_RS20880	COG2923	Belongs to the DsrF TusC family
HV128_RS20885	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV128_RS20890	COG2964	Protein conserved in bacteria
HV128_RS20895	COG0545	Peptidyl-prolyl cis-trans isomerase
HV128_RS20905	COG1047	Peptidyl-prolyl cis-trans
HV128_RS20910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV128_RS20915	COG0475	glutathione-regulated potassium exporter activity
HV128_RS20915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV128_RS20920	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV128_RS20925	COG0488	(ABC) transporter
HV128_RS20935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV128_RS20945	COG0679	Auxin Efflux Carrier
HV128_RS20975	COG0429	hydrolase of the alpha beta-hydrolase fold
HV128_RS20980	COG3089	Belongs to the UPF0270 family
HV128_RS20985	COG3954	Phosphoribulokinase
HV128_RS20990	COG1765	OsmC-like protein
HV128_RS21000	COG1289	transmembrane transporter activity
HV128_RS21005	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV128_RS21010	COG0512	Glutamine amidotransferase of anthranilate synthase
HV128_RS21015	COG2184	nucleotidyltransferase activity
HV128_RS21025	COG0738	Major facilitator superfamily
HV128_RS21030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV128_RS21040	COG1648	precorrin-2 dehydrogenase activity
HV128_RS21040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV128_RS21050	COG0180	Tryptophanyl-tRNA synthetase
HV128_RS21060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV128_RS21065	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV128_RS21070	COG3266	domain, Protein
HV128_RS21075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HV128_RS21080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV128_RS21085	COG4796	Type ii and iii secretion system protein
HV128_RS21105	COG4972	Pilus assembly protein
HV128_RS21110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV128_RS21115	COG0494	nUDIX hydrolase
HV128_RS21125	COG1011	Hydrolase
HV128_RS21130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV128_RS21135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HV128_RS21140	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV128_RS21145	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HV128_RS21155	COG0745	RESPONSE REGULATOR receiver
HV128_RS21160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV128_RS21165	COG2183	response to ionizing radiation
HV128_RS21170	COG1918	ferrous iron import across plasma membrane
HV128_RS21190	COG1040	competence protein
HV128_RS21200	COG2610	gluconate transmembrane transporter activity
HV128_RS21205	COG1640	4-alpha-glucanotransferase
HV128_RS21210	COG0058	SHG alpha-glucan phosphorylase activity
HV128_RS21215	COG2909	trisaccharide binding
HV128_RS21220	COG1349	DNA-binding transcription factor activity
HV128_RS21225	COG0705	Rhomboid family
HV128_RS21230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV128_RS21235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV128_RS21240	COG0058	SHG alpha-glucan phosphorylase activity
HV128_RS21245	COG0297	glycogen (starch) synthase activity
HV128_RS21250	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HV128_RS21255	COG1523	belongs to the glycosyl hydrolase 13 family
HV128_RS21260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HV128_RS21265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV128_RS21270	COG2095	MarC family integral membrane protein
HV128_RS21280	COG2610	gluconate transmembrane transporter activity
HV128_RS21285	COG3265	gluconokinase activity
HV128_RS21290	COG1609	Transcriptional regulator
HV128_RS21295	COG1741	Belongs to the pirin family
HV128_RS21300	COG0673	inositol 2-dehydrogenase activity
HV128_RS21305	COG1247	-acetyltransferase
HV128_RS21310	COG0405	Gamma-glutamyltransferase
HV128_RS21320	COG0584	glycerophosphoryl diester phosphodiesterase
HV128_RS21350	COG0411	ABC transporter
HV128_RS21355	COG4177	L-phenylalanine transmembrane transporter activity
HV128_RS21365	COG0683	leucine binding
HV128_RS21370	COG0456	acetyltransferase
HV128_RS21375	COG0683	leucine binding
HV128_RS21380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV128_RS21385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV128_RS21390	COG2177	Part of the ABC transporter FtsEX involved in
HV128_RS21395	COG2884	Cell division ATP-binding protein ftsE
HV128_RS21400	COG0552	protein localization to endoplasmic reticulum
HV128_RS21405	COG0742	ribosomal rna small subunit methyltransferase
HV128_RS21410	COG3776	membrane
HV128_RS21420	COG3714	YhhN family
HV128_RS21425	COG2217	Heavy metal translocating P-type atpase
HV128_RS21440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV128_RS21445	COG0425	Belongs to the sulfur carrier protein TusA family
HV128_RS21450	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV128_RS21460	COG0628	permease
HV128_RS21480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV128_RS21500	COG1216	Glycosyl transferase, family 2
HV128_RS21525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV128_RS21535	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS21540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV128_RS21550	COG3479	Phenolic acid decarboxylase
HV128_RS21555	COG0583	DNA-binding transcription factor activity
HV128_RS21560	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS21580	COG1414	Transcriptional regulator
HV128_RS21585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HV128_RS21590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV128_RS21600	COG2205	protein histidine kinase activity
HV128_RS21605	COG0745	RESPONSE REGULATOR receiver
HV128_RS21610	COG1276	copper resistance
HV128_RS21615	COG2372	response to copper ion
HV128_RS21620	COG3667	copper resistance
HV128_RS21625	COG2132	Multicopper oxidase
HV128_RS21635	COG0739	heme binding
HV128_RS21665	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV128_RS21740	COG2081	HI0933 family
HV128_RS21745	COG0306	phosphate transporter
HV128_RS21755	COG0589	response to stress
HV128_RS21760	COG0742	ribosomal rna small subunit methyltransferase
HV128_RS21765	COG0339	signal peptide processing
HV128_RS21770	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV128_RS21775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV128_RS21795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV128_RS21805	COG2197	response regulator
HV128_RS21810	COG1028	Short-chain dehydrogenase reductase Sdr
HV128_RS21815	COG0583	DNA-binding transcription factor activity
HV128_RS21820	COG1295	ribonuclease BN
HV128_RS21825	COG0477	Major facilitator Superfamily
HV128_RS21830	COG2982	Protein involved in outer membrane biogenesis
HV128_RS21835	COG2200	EAL domain
HV128_RS21845	COG0612	Peptidase, M16
HV128_RS21850	COG1301	dicarboxylic acid transport
HV128_RS21855	COG2200	EAL domain
HV128_RS21855	COG2199	diguanylate cyclase activity
HV128_RS21860	COG0457	Tetratricopeptide repeat
HV128_RS21860	COG3118	belongs to the thioredoxin family
HV128_RS21865	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HV128_RS21870	COG1215	transferase activity, transferring glycosyl groups
HV128_RS21900	COG2194	sulfuric ester hydrolase activity
HV128_RS21910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV128_RS21940	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HV128_RS21950	COG1739	Uncharacterized protein family UPF0029
HV128_RS21955	COG0006	proline dipeptidase activity
HV128_RS21960	COG1024	Enoyl-CoA hydratase
HV128_RS21960	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV128_RS21965	COG0183	Belongs to the thiolase family
HV128_RS21970	COG0751	glycine-tRNA ligase activity
HV128_RS21975	COG0752	glycyl-tRNA synthetase alpha subunit
HV128_RS21985	COG3274	enterobacterial common antigen metabolic process
HV128_RS21990	COG1070	Carbohydrate kinase
HV128_RS21995	COG2115	Belongs to the xylose isomerase family
HV128_RS22000	COG4213	ABC transporter substrate-binding protein
HV128_RS22010	COG4214	carbohydrate transport
HV128_RS22015	COG1609	Transcriptional regulator
HV128_RS22015	COG2207	Transcriptional regulator
HV128_RS22020	COG2992	FlgJ-related protein
HV128_RS22025	COG0366	Alpha amylase catalytic
HV128_RS22030	COG3977	Valine--pyruvate aminotransferase
HV128_RS22035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV128_RS22040	COG1414	Transcriptional regulator
HV128_RS22050	COG2731	YhcH YjgK YiaL family protein
HV128_RS22060	COG2271	Major facilitator Superfamily
HV128_RS22065	COG1070	Carbohydrate kinase
HV128_RS22070	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV128_RS22075	COG3623	hexulose-6-phosphate isomerase
HV128_RS22080	COG0235	Class ii aldolase
HV128_RS22090	COG2211	Major facilitator Superfamily
HV128_RS22100	COG1012	belongs to the aldehyde dehydrogenase family
HV128_RS22105	COG1940	carbohydrate kinase activity
HV128_RS22110	COG3276	selenocysteine insertion sequence binding
HV128_RS22120	COG0625	glutathione transferase activity
HV128_RS22125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV128_RS22125	COG2213	PTS system mannitol-specific
HV128_RS22135	COG3722	fumarate hydratase activity
HV128_RS22155	COG3121	Chaperone
HV128_RS22160	COG3539	Fimbrial protein
HV128_RS22170	COG2186	Transcriptional regulator
HV128_RS22180	COG2271	Major facilitator Superfamily
HV128_RS22185	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV128_RS22195	COG0583	DNA-binding transcription factor activity
HV128_RS22200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV128_RS22210	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV128_RS22215	COG3978	acetolactate synthase activity
HV128_RS22235	COG3085	chromosome segregation
HV128_RS22285	COG4206	TonB-dependent receptor
HV128_RS22290	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV128_RS22310	COG0583	DNA-binding transcription factor activity
HV128_RS22315	COG0165	Argininosuccinate lyase
HV128_RS22325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HV128_RS22330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV128_RS22335	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HV128_RS22340	COG0371	Dehydrogenase
HV128_RS22345	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HV128_RS22355	COG0527	aspartate kinase activity
HV128_RS22355	COG0460	homoserine dehydrogenase
HV128_RS22360	COG0626	cystathionine gamma-synthase activity
HV128_RS22375	COG0254	rRNA binding
HV128_RS22380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV128_RS22385	COG1609	Transcriptional regulator
HV128_RS22390	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV128_RS22405	COG1575	Belongs to the MenA family. Type 1 subfamily
HV128_RS22410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HV128_RS22415	COG3074	FtsZ-dependent cytokinesis
HV128_RS22420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV128_RS22430	COG1494	fructose-1,6-bisphosphatase
HV128_RS22440	COG3152	Membrane
HV128_RS22450	COG0149	triose-phosphate isomerase activity
HV128_RS22460	COG2134	cdp-diacylglycerol pyrophosphatase
HV128_RS22470	COG0205	6-phosphofructokinase activity
HV128_RS22480	COG3678	ATP-independent chaperone mediated protein folding
HV128_RS22485	COG0745	RESPONSE REGULATOR receiver
HV128_RS22490	COG2205	protein histidine kinase activity
HV128_RS22495	COG2258	MOSC domain
HV128_RS22510	COG1917	Cupin 2, conserved barrel domain protein
HV128_RS22510	COG4977	sequence-specific DNA binding
HV128_RS22515	COG4977	sequence-specific DNA binding
HV128_RS22520	COG1070	Carbohydrate kinase
HV128_RS22525	COG4806	L-rhamnose isomerase
HV128_RS22530	COG0235	Class ii aldolase
HV128_RS22540	COG1129	ABC transporter
HV128_RS22545	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV128_RS22555	COG1454	alcohol dehydrogenase
HV128_RS22560	COG3254	rhamnose metabolic process
HV128_RS22565	COG2211	Major facilitator Superfamily
HV128_RS22585	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV128_RS22600	COG3188	usher protein
HV128_RS22605	COG3121	Chaperone
HV128_RS22630	COG0437	4 iron, 4 sulfur cluster binding
HV128_RS22635	COG2864	formate dehydrogenase
HV128_RS22640	COG3058	Necessary for formate dehydrogenase activity
HV128_RS22650	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV128_RS22660	COG0456	acetyltransferase
HV128_RS22675	COG1011	Hydrolase
HV128_RS22680	COG1349	DNA-binding transcription factor activity
HV128_RS22685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV128_RS22695	COG3684	Belongs to the aldolase LacD family
HV128_RS22705	COG1501	Belongs to the glycosyl hydrolase 31 family
HV128_RS22725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV128_RS22740	COG3852	Histidine kinase
HV128_RS22755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV128_RS22760	COG3078	GTPase activator activity
HV128_RS22775	COG0204	Acyl-transferase
HV128_RS22785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HV128_RS22790	COG3084	Protein conserved in bacteria
HV128_RS22795	COG0746	molybdenum cofactor guanylyltransferase activity
HV128_RS22800	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV128_RS22825	COG2186	Transcriptional regulator
HV128_RS22830	COG0477	Major facilitator Superfamily
HV128_RS22835	COG1609	Transcriptional regulator
HV128_RS22840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV128_RS22850	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV128_RS22855	COG1129	ABC transporter
HV128_RS22860	COG1869	D-ribose catabolic process
HV128_RS22865	COG3158	transport of potassium into the cell
HV128_RS22875	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HV128_RS22880	COG2502	aspartate--ammonia ligase
HV128_RS22885	COG1522	sequence-specific DNA binding
HV128_RS22890	COG0716	FMN binding
HV128_RS22895	COG0445	tRNA wobble uridine modification
HV128_RS22900	COG0357	Ribosomal RNA small subunit methyltransferase G
HV128_RS22905	COG3312	ion transport
HV128_RS22910	COG0356	it plays a direct role in the translocation of protons across the membrane
HV128_RS22920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HV128_RS22925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HV128_RS22940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV128_RS22945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV128_RS22950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV128_RS22960	COG3539	Fimbrial protein
HV128_RS22965	COG3121	Chaperone
HV128_RS22975	COG3539	Fimbrial protein
HV128_RS22980	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV128_RS22985	COG0573	inorganic phosphate transmembrane transporter activity
HV128_RS22990	COG0581	inorganic phosphate transmembrane transporter activity
HV128_RS22995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HV128_RS23000	COG0704	Plays a role in the regulation of phosphate uptake
HV128_RS23005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV128_RS23010	COG2252	PERMEase
HV128_RS23015	COG0431	NADPH-dependent FMN reductase
HV128_RS23020	COG2091	lysine biosynthetic process via aminoadipic acid
HV128_RS23035	COG0456	acetyltransferase
HV128_RS23045	COG0706	membrane insertase activity
HV128_RS23090	COG0501	Belongs to the peptidase M48B family
HV128_RS23095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV128_RS23115	COG4644	lycopene metabolic process
HV128_RS23160	COG0589	response to stress
HV128_RS23165	COG0659	secondary active sulfate transmembrane transporter activity
HV128_RS23215	COG4644	lycopene metabolic process
HV128_RS23230	COG3344	reverse transcriptase
HV128_RS23315	COG0071	Belongs to the small heat shock protein (HSP20) family
HV128_RS23320	COG0542	response to heat
HV128_RS23415	COG3093	addiction module antidote protein HigA
HV128_RS23420	COG3549	Plasmid maintenance system killer