locus-tag	class	description
HV326_RS00010	COG0592	DNA-directed DNA polymerase activity
HV326_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HV326_RS00025	COG0583	DNA-binding transcription factor activity
HV326_RS00030	COG3321	synthase
HV326_RS00030	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS00030	COG0604	alcohol dehydrogenase
HV326_RS00035	COG0561	phosphatase activity
HV326_RS00040	COG2186	Transcriptional regulator
HV326_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HV326_RS00050	COG0800	Aldolase
HV326_RS00055	COG4948	Mandelate Racemase Muconate Lactonizing
HV326_RS00060	COG2271	Major facilitator Superfamily
HV326_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
HV326_RS00070	COG5645	(Lipo)protein
HV326_RS00080	COG0071	Belongs to the small heat shock protein (HSP20) family
HV326_RS00085	COG2985	domain, Protein
HV326_RS00090	COG2188	Transcriptional regulator
HV326_RS00105	COG2149	membrane
HV326_RS00125	COG2814	Major facilitator Superfamily
HV326_RS00150	COG5499	transcription regulator containing HTH domain
HV326_RS00160	COG0028	Belongs to the TPP enzyme family
HV326_RS00165	COG0440	acetolactate synthase activity
HV326_RS00170	COG2197	response regulator
HV326_RS00195	COG0583	DNA-binding transcription factor activity
HV326_RS00215	COG0697	spore germination
HV326_RS00220	COG4580	involved in the transport of maltose and maltodextrins
HV326_RS00225	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV326_RS00230	COG2723	6-phospho-beta-galactosidase activity
HV326_RS00235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV326_RS00235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV326_RS00245	COG1609	Transcriptional regulator
HV326_RS00255	COG2814	Major facilitator Superfamily
HV326_RS00265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV326_RS00270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV326_RS00280	COG0454	-acetyltransferase
HV326_RS00285	COG1309	transcriptional regulator
HV326_RS00315	COG3188	usher protein
HV326_RS00345	COG3188	usher protein
HV326_RS00370	COG2274	protein secretion by the type I secretion system
HV326_RS00385	COG2161	toxin-antitoxin pair type II binding
HV326_RS00390	COG4115	mRNA cleavage
HV326_RS00405	COG3272	Protein of unknown function (DUF1722)
HV326_RS00410	COG2351	hydroxyisourate hydrolase activity
HV326_RS00440	COG3121	Chaperone
HV326_RS00510	COG2003	Belongs to the UPF0758 family
HV326_RS00525	COG2378	regulation of single-species biofilm formation
HV326_RS00530	COG3596	GTP binding
HV326_RS00555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HV326_RS00565	COG0582	viral genome integration into host DNA
HV326_RS00575	COG2211	Major facilitator Superfamily
HV326_RS00580	COG1501	Belongs to the glycosyl hydrolase 31 family
HV326_RS00585	COG2982	Protein involved in outer membrane biogenesis
HV326_RS00590	COG2233	PERMEase
HV326_RS00595	COG0786	glutamate:sodium symporter activity
HV326_RS00600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV326_RS00605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV326_RS00610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV326_RS00625	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HV326_RS00645	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV326_RS00650	COG1596	polysaccharide export
HV326_RS00655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HV326_RS00660	COG0489	protein tyrosine kinase activity
HV326_RS00660	COG3206	protein involved in exopolysaccharide biosynthesis
HV326_RS00665	COG2860	membrane
HV326_RS00670	COG1561	YicC-like family, N-terminal region
HV326_RS00680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HV326_RS00690	COG0756	dUTP diphosphatase activity
HV326_RS00695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV326_RS00700	COG2003	Belongs to the UPF0758 family
HV326_RS00705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HV326_RS00710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV326_RS00715	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HV326_RS00720	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HV326_RS00730	COG1519	Transferase
HV326_RS00735	COG1216	Glycosyl transferase, family 2
HV326_RS00740	COG0438	transferase activity, transferring glycosyl groups
HV326_RS00750	COG0859	PFAM glycosyl transferase family 9
HV326_RS00760	COG1216	Glycosyl transferase, family 2
HV326_RS00770	COG0859	PFAM glycosyl transferase family 9
HV326_RS00775	COG0859	PFAM glycosyl transferase family 9
HV326_RS00790	COG1063	alcohol dehydrogenase
HV326_RS00800	COG0438	transferase activity, transferring glycosyl groups
HV326_RS00805	COG0463	Glycosyl transferase, family 2
HV326_RS00810	COG2861	carbohydrate metabolic process
HV326_RS00815	COG4942	peptidase
HV326_RS00820	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HV326_RS00825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV326_RS00830	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV326_RS00835	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HV326_RS00840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HV326_RS00850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV326_RS00860	COG0248	Ppx GppA phosphatase
HV326_RS00870	COG3118	belongs to the thioredoxin family
HV326_RS00875	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV326_RS00880	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV326_RS00890	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HV326_RS00895	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV326_RS00900	COG0456	acetyltransferase
HV326_RS00905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV326_RS00910	COG2244	polysaccharide biosynthetic process
HV326_RS00925	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HV326_RS00960	COG3071	HemY protein
HV326_RS00965	COG2959	enzyme of heme biosynthesis
HV326_RS00975	COG0181	hydroxymethylbilane synthase activity
HV326_RS00990	COG5567	small periplasmic lipoprotein
HV326_RS01010	COG1011	Hydrolase
HV326_RS01015	COG0210	DNA helicase
HV326_RS01035	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HV326_RS01045	COG1280	lysine exporter protein (LysE YggA)
HV326_RS01050	COG1280	lysine exporter protein (LysE YggA)
HV326_RS01055	COG2267	carboxylic ester hydrolase activity
HV326_RS01060	COG0561	phosphatase activity
HV326_RS01065	COG0697	spore germination
HV326_RS01070	COG0583	DNA-binding transcription factor activity
HV326_RS01080	COG0412	Dienelactone hydrolase
HV326_RS01090	COG1322	Protein conserved in bacteria
HV326_RS01095	COG2226	methyltransferase
HV326_RS01100	COG3165	ubiquinone biosynthetic process from chorismate
HV326_RS01105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HV326_RS01120	COG0805	protein transport
HV326_RS01125	COG0084	hydrolase, TatD family'
HV326_RS01135	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV326_RS01150	COG2944	sequence-specific DNA binding
HV326_RS01160	COG1278	Cold shock
HV326_RS01165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV326_RS01175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV326_RS01185	COG1609	Transcriptional regulator
HV326_RS01190	COG2885	chlorophyll binding
HV326_RS01195	COG0243	molybdopterin cofactor binding
HV326_RS01200	COG0456	acetyltransferase
HV326_RS01205	COG2818	Glycosylase
HV326_RS01210	COG5571	outer membrane autotransporter
HV326_RS01215	COG2223	nitrite transmembrane transporter activity
HV326_RS01255	COG0747	negative chemotaxis
HV326_RS01260	COG0601	transmembrane transport
HV326_RS01265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV326_RS01270	COG0444	Belongs to the ABC transporter superfamily
HV326_RS01275	COG4608	Belongs to the ABC transporter superfamily
HV326_RS01280	COG1072	(Pantothenic acid kinase))
HV326_RS01315	COG0250	Participates in transcription elongation, termination and antitermination
HV326_RS01360	COG3706	GGDEF domain
HV326_RS01370	COG2022	thiamine diphosphate biosynthetic process
HV326_RS01375	COG2104	thiamine diphosphate biosynthetic process
HV326_RS01380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV326_RS01395	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HV326_RS01405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HV326_RS01410	COG1515	deoxyribonuclease V activity
HV326_RS01415	COG3068	Protein conserved in bacteria
HV326_RS01430	COG0151	Belongs to the GarS family
HV326_RS01460	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV326_RS01470	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HV326_RS01490	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV326_RS01495	COG3657	addiction module killer protein
HV326_RS01500	COG1187	pseudouridine synthase activity
HV326_RS01515	COG0527	aspartate kinase activity
HV326_RS01540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV326_RS01545	COG3223	Belongs to the PsiE family
HV326_RS01570	COG4580	involved in the transport of maltose and maltodextrins
HV326_RS01580	COG3161	chorismate lyase activity
HV326_RS01590	COG2937	Belongs to the GPAT DAPAT family
HV326_RS01595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV326_RS01600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV326_RS01605	COG0534	Mate efflux family protein
HV326_RS01610	COG3237	CsbD-like
HV326_RS01615	COG0735	belongs to the Fur family
HV326_RS01630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV326_RS01640	COG0604	alcohol dehydrogenase
HV326_RS01645	COG0305	Participates in initiation and elongation during chromosome replication
HV326_RS01655	COG1448	Aminotransferase
HV326_RS01660	COG3700	Belongs to the class B bacterial acid phosphatase family
HV326_RS01670	COG2315	Protein conserved in bacteria
HV326_RS01680	COG0629	single-stranded DNA binding
HV326_RS01695	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV326_RS01705	COG0789	Transcriptional regulator
HV326_RS01710	COG0625	glutathione transferase activity
HV326_RS01715	COG2252	PERMEase
HV326_RS01720	COG0025	NhaP-type Na H and K H
HV326_RS01725	COG0583	DNA-binding transcription factor activity
HV326_RS01735	COG1346	cytolysis
HV326_RS01740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV326_RS01745	COG3162	membrane
HV326_RS01755	COG1301	dicarboxylic acid transport
HV326_RS01760	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV326_RS01775	COG0745	RESPONSE REGULATOR receiver
HV326_RS01785	COG0191	fructose-bisphosphate aldolase activity
HV326_RS01800	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV326_RS01805	COG1129	ABC transporter
HV326_RS01810	COG0784	Response regulator, receiver
HV326_RS01810	COG4191	Histidine kinase
HV326_RS01820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV326_RS01825	COG0456	acetyltransferase
HV326_RS01830	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HV326_RS01835	COG3454	Phosphonate metabolism
HV326_RS01840	COG4778	phosphonate C-P lyase system protein PhnL
HV326_RS01845	COG4107	phosphonate C-P lyase system protein PhnK
HV326_RS01850	COG3627	carbon phosphorus lyase activity
HV326_RS01855	COG3626	phosphonate metabolism
HV326_RS01860	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV326_RS01865	COG3624	Phosphonate C-P lyase system protein PhnG
HV326_RS01870	COG2188	Transcriptional regulator
HV326_RS01875	COG3639	organic phosphonate transmembrane transporter activity
HV326_RS01880	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV326_RS01890	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV326_RS01895	COG2824	Alkylphosphonate utilization operon protein PhnA
HV326_RS01900	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HV326_RS01920	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV326_RS01945	COG3647	Membrane
HV326_RS01980	COG2378	regulation of single-species biofilm formation
HV326_RS01985	COG4735	regulation of single-species biofilm formation
HV326_RS02020	COG4974	Belongs to the 'phage' integrase family
HV326_RS02060	COG1309	transcriptional regulator
HV326_RS02075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV326_RS02080	COG1027	Aspartate ammonia-lyase
HV326_RS02085	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV326_RS02090	COG0531	amino acid
HV326_RS02100	COG0459	protein refolding
HV326_RS02105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV326_RS02110	COG0700	Nucleoside recognition
HV326_RS02115	COG3366	ferrous iron transmembrane transporter activity
HV326_RS02140	COG5510	response to toxic substance
HV326_RS02165	COG0583	DNA-binding transcription factor activity
HV326_RS02175	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HV326_RS02180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV326_RS02185	COG1053	succinate dehydrogenase
HV326_RS02190	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HV326_RS02200	COG3264	Mechanosensitive ion channel
HV326_RS02200	COG1511	domain protein
HV326_RS02235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV326_RS02240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV326_RS02240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV326_RS02245	COG0802	atpase or kinase
HV326_RS02255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HV326_RS02260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HV326_RS02265	COG1923	regulation of RNA biosynthetic process
HV326_RS02270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV326_RS02275	COG0330	HflC and HflK could
HV326_RS02280	COG0330	HflC and HflK could
HV326_RS02285	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV326_RS02295	COG1959	2 iron, 2 sulfur cluster binding
HV326_RS02300	COG0557	exoribonuclease II activity
HV326_RS02305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV326_RS02310	COG3789	protein conserved in bacteria
HV326_RS02315	COG1842	Phage shock protein A
HV326_RS02330	COG3766	membrane
HV326_RS02335	COG5463	Belongs to the UPF0441 family
HV326_RS02340	COG0754	glutathionylspermidine amidase activity
HV326_RS02345	COG0477	Major facilitator Superfamily
HV326_RS02350	COG1960	acyl-CoA dehydrogenase activity
HV326_RS02365	COG3650	response to hydrogen peroxide
HV326_RS02370	COG1073	alpha beta
HV326_RS02385	COG3037	sugar-specific permease SgaT UlaA
HV326_RS02425	COG2965	DNA replication, synthesis of RNA primer
HV326_RS02430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV326_RS02435	COG0359	binds to the 23S rRNA
HV326_RS02440	COG0697	spore germination
HV326_RS02445	COG3061	Opacity-associated protein A
HV326_RS02450	COG0545	Peptidyl-prolyl cis-trans isomerase
HV326_RS02455	COG1113	amino acid transport
HV326_RS02465	COG0840	transmembrane signaling receptor activity
HV326_RS02470	COG0697	spore germination
HV326_RS02480	COG0702	epimerase
HV326_RS02485	COG1733	regulation of RNA biosynthetic process
HV326_RS02495	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV326_RS02500	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV326_RS02510	COG1253	flavin adenine dinucleotide binding
HV326_RS02515	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV326_RS02520	COG0729	surface antigen
HV326_RS02525	COG2911	Protein conserved in bacteria
HV326_RS02530	COG2105	PFAM AIG2 family protein
HV326_RS02540	COG1879	ABC-type sugar transport system periplasmic component
HV326_RS02545	COG1129	ABC transporter
HV326_RS02550	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV326_RS02555	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV326_RS02570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV326_RS02575	COG3028	Belongs to the UPF0307 family
HV326_RS02580	COG0312	modulator of DNA gyrase
HV326_RS02620	COG3964	amidohydrolase
HV326_RS02635	COG2706	6-phosphogluconolactonase activity
HV326_RS02640	COG3711	transcriptional antiterminator
HV326_RS02640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS02645	COG0602	queuosine metabolic process
HV326_RS02655	COG0366	Alpha amylase catalytic
HV326_RS02660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV326_RS02660	COG1263	PTS System
HV326_RS02665	COG1609	Transcriptional regulator
HV326_RS02675	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HV326_RS02680	COG3397	chitin binding
HV326_RS02685	COG0251	oxidation-reduction process
HV326_RS02695	COG0540	Belongs to the ATCase OTCase family
HV326_RS02710	COG1438	arginine binding
HV326_RS02715	COG1288	antiporter activity
HV326_RS02730	COG2235	arginine
HV326_RS02735	COG2731	YhcH YjgK YiaL family protein
HV326_RS02740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV326_RS02745	COG0129	dihydroxy-acid dehydratase activity
HV326_RS02750	COG2211	Major facilitator Superfamily
HV326_RS02755	COG3507	Belongs to the glycosyl hydrolase 43 family
HV326_RS02760	COG1414	Transcriptional regulator
HV326_RS02765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV326_RS02790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV326_RS02795	COG0732	type I restriction modification DNA specificity domain
HV326_RS02835	COG1609	Transcriptional regulator
HV326_RS02845	COG2211	Major facilitator Superfamily
HV326_RS02855	COG1401	restriction endodeoxyribonuclease activity
HV326_RS02880	COG1335	isochorismatase
HV326_RS02895	COG2204	response regulator
HV326_RS02900	COG4191	Histidine kinase
HV326_RS02905	COG4566	intracellular signal transduction
HV326_RS02910	COG0740	serine-type endopeptidase activity
HV326_RS02915	COG2850	peptidyl-arginine hydroxylation
HV326_RS02920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV326_RS02925	COG5457	Domain of unknown function (DUF1127)
HV326_RS02940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV326_RS02950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV326_RS02960	COG2733	membrane
HV326_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS02995	COG3307	-O-antigen
HV326_RS03000	COG0523	cobalamin synthesis protein
HV326_RS03005	COG2879	small protein
HV326_RS03010	COG1966	Carbon starvation protein
HV326_RS03015	COG1349	DNA-binding transcription factor activity
HV326_RS03020	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV326_RS03025	COG2368	4-hydroxyphenylacetate
HV326_RS03045	COG3971	2-oxopent-4-enoate hydratase activity
HV326_RS03055	COG3384	dioxygenase
HV326_RS03060	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS03065	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV326_RS03070	COG1846	Transcriptional regulator
HV326_RS03075	COG0840	transmembrane signaling receptor activity
HV326_RS03095	COG1484	DNA-dependent DNA replication
HV326_RS03105	COG1764	response to oxidative stress
HV326_RS03110	COG1846	Transcriptional regulator
HV326_RS03115	COG3610	response to peptide
HV326_RS03120	COG2966	Psort location CytoplasmicMembrane, score
HV326_RS03125	COG2197	response regulator
HV326_RS03130	COG2197	response regulator
HV326_RS03135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV326_RS03140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV326_RS03140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV326_RS03145	COG4114	ferric iron reductase
HV326_RS03150	COG3706	GGDEF domain
HV326_RS03175	COG2813	Specifically methylates the guanine in position
HV326_RS03180	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV326_RS03185	COG0456	acetyltransferase
HV326_RS03190	COG1011	Hydrolase
HV326_RS03195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HV326_RS03200	COG2823	Periplasmic or secreted lipoprotein
HV326_RS03205	COG5487	UPF0391 membrane protein
HV326_RS03210	COG4667	esterase of the alpha-beta hydrolase superfamily
HV326_RS03215	COG0084	hydrolase, TatD family'
HV326_RS03220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV326_RS03225	COG1328	CTP reductase activity
HV326_RS03235	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HV326_RS03260	COG3726	membrane protein affecting hemolysin expression
HV326_RS03265	COG0560	Phosphoserine phosphatase
HV326_RS03290	COG0488	(ABC) transporter
HV326_RS03295	COG0741	lytic transglycosylase activity
HV326_RS03300	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HV326_RS03305	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HV326_RS03310	COG0406	alpha-ribazole phosphatase activity
HV326_RS03315	COG2207	Transcriptional regulator
HV326_RS03315	COG3708	Transcriptional regulator
HV326_RS03320	COG3045	CreA protein
HV326_RS03325	COG0745	RESPONSE REGULATOR receiver
HV326_RS03335	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV326_RS03345	COG0527	aspartate kinase activity
HV326_RS03345	COG0460	homoserine dehydrogenase
HV326_RS03355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV326_RS03370	COG1115	amino acid carrier protein
HV326_RS03380	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV326_RS03385	COG0477	Major facilitator Superfamily
HV326_RS03390	COG1584	GPR1 FUN34 yaaH family protein
HV326_RS03400	COG0443	Heat shock 70 kDa protein
HV326_RS03410	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV326_RS03415	COG0583	DNA-binding transcription factor activity
HV326_RS03420	COG0268	Binds directly to 16S ribosomal RNA
HV326_RS03425	COG0196	riboflavin kinase activity
HV326_RS03440	COG1047	Peptidyl-prolyl cis-trans
HV326_RS03445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HV326_RS03455	COG0505	Belongs to the CarA family
HV326_RS03480	COG0475	glutathione-regulated potassium exporter activity
HV326_RS03480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV326_RS03490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV326_RS03495	COG2967	ApaG domain
HV326_RS03505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HV326_RS03510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV326_RS03515	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV326_RS03520	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV326_RS03525	COG0564	pseudouridine synthase activity
HV326_RS03530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HV326_RS03535	COG0417	DNA replication proofreading
HV326_RS03540	COG0235	Class ii aldolase
HV326_RS03545	COG2160	L-arabinose isomerase activity
HV326_RS03550	COG1069	ribulokinase activity
HV326_RS03560	COG0586	Pfam SNARE associated Golgi protein
HV326_RS03570	COG1178	ABC-type Fe3 transport system permease component
HV326_RS03590	COG2814	Major facilitator Superfamily
HV326_RS03615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV326_RS03630	COG0028	Belongs to the TPP enzyme family
HV326_RS03640	COG1609	Transcriptional regulator
HV326_RS03645	COG2001	Belongs to the MraZ family
HV326_RS03660	COG0768	penicillin binding
HV326_RS03665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV326_RS03670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV326_RS03675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV326_RS03685	COG0772	Belongs to the SEDS family
HV326_RS03700	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV326_RS03710	COG0849	cell division
HV326_RS03715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV326_RS03720	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HV326_RS03730	COG0653	protein targeting
HV326_RS03735	COG0494	nUDIX hydrolase
HV326_RS03740	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HV326_RS03745	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HV326_RS03755	COG0516	GMP reductase activity
HV326_RS03760	COG1459	type II secretion system
HV326_RS03765	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV326_RS03770	COG4969	Belongs to the N-Me-Phe pilin family
HV326_RS03780	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV326_RS03785	COG3725	Membrane protein required for beta-lactamase induction
HV326_RS03790	COG3940	Belongs to the glycosyl hydrolase 43 family
HV326_RS03795	COG2211	Major facilitator Superfamily
HV326_RS03800	COG1113	amino acid transport
HV326_RS03805	COG2186	Transcriptional regulator
HV326_RS03810	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV326_RS03815	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV326_RS03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV326_RS03830	COG3064	Membrane
HV326_RS03850	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HV326_RS03875	COG4993	Dehydrogenase
HV326_RS03900	COG3561	AntA/AntB antirepressor
HV326_RS03975	COG4626	Terminase
HV326_RS03975	COG1802	Transcriptional regulator
HV326_RS03990	COG0288	reversible hydration of carbon dioxide
HV326_RS03995	COG1131	(ABC) transporter
HV326_RS04000	COG0842	Transport permease protein
HV326_RS04005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS04010	COG0726	polysaccharide deacetylase
HV326_RS04030	COG3539	Fimbrial protein
HV326_RS04035	COG3188	usher protein
HV326_RS04040	COG3121	Chaperone
HV326_RS04050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HV326_RS04055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HV326_RS04065	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV326_RS04070	COG0617	tRNA 3'-terminal CCA addition
HV326_RS04075	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV326_RS04085	COG1489	DNA binding
HV326_RS04090	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV326_RS04095	COG1643	Atp-dependent helicase
HV326_RS04100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV326_RS04110	COG1120	ATPase activity
HV326_RS04115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV326_RS04120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV326_RS04125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HV326_RS04135	COG0316	Belongs to the HesB IscA family
HV326_RS04140	COG2860	membrane
HV326_RS04150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV326_RS04155	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HV326_RS04165	COG3835	regulator
HV326_RS04210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV326_RS04220	COG0575	Belongs to the CDS family
HV326_RS04225	COG0750	zinc metalloprotease
HV326_RS04230	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV326_RS04245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HV326_RS04250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV326_RS04255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV326_RS04260	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HV326_RS04270	COG0825	malonyl-CoA metabolic process
HV326_RS04280	COG0346	lactoylglutathione lyase activity
HV326_RS04285	COG0037	tRNA processing
HV326_RS04290	COG4568	rho-dependent transcription termination
HV326_RS04305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV326_RS04310	COG3015	lipoprotein NlpE involved in copper resistance
HV326_RS04320	COG1720	tRNA m6t6A37 methyltransferase activity
HV326_RS04330	COG1464	Belongs to the NlpA lipoprotein family
HV326_RS04335	COG2011	ABC-type metal ion transport system permease component
HV326_RS04345	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV326_RS04385	COG0583	DNA-binding transcription factor activity
HV326_RS04390	COG2814	Major facilitator Superfamily
HV326_RS04395	COG3021	interspecies interaction between organisms
HV326_RS04400	COG2226	methyltransferase
HV326_RS04405	COG1388	LysM domain
HV326_RS04405	COG0741	lytic transglycosylase activity
HV326_RS04410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV326_RS04415	COG2226	methyltransferase
HV326_RS04435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV326_RS04450	COG0121	glutamine amidotransferase
HV326_RS04455	COG3034	peptidoglycan biosynthetic process
HV326_RS04470	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV326_RS04475	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HV326_RS04490	COG2991	Protein conserved in bacteria
HV326_RS04495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV326_RS04500	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV326_RS04535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV326_RS04540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HV326_RS04590	COG5002	protein histidine kinase activity
HV326_RS04600	COG0667	Aldo Keto reductase
HV326_RS04610	COG0778	Nitroreductase
HV326_RS04615	COG2814	Major facilitator Superfamily
HV326_RS04650	COG3596	GTP binding
HV326_RS04660	COG2378	regulation of single-species biofilm formation
HV326_RS04685	COG2003	Belongs to the UPF0758 family
HV326_RS04705	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV326_RS04715	COG3300	MHYT domain
HV326_RS04715	COG5001	Diguanylate cyclase
HV326_RS04730	COG0628	permease
HV326_RS04735	COG0833	amino acid
HV326_RS04740	COG2040	homocysteine
HV326_RS04745	COG4521	taurine ABC transporter
HV326_RS04750	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV326_RS04755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV326_RS04760	COG2175	clavaminate synthase activity
HV326_RS04770	COG0113	porphobilinogen synthase activity
HV326_RS04785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV326_RS04790	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV326_RS04810	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV326_RS04835	COG3706	GGDEF domain
HV326_RS04840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV326_RS04845	COG1671	Belongs to the UPF0178 family
HV326_RS04850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV326_RS04860	COG4126	flavin adenine dinucleotide binding
HV326_RS04865	COG3123	guanosine phosphorylase activity
HV326_RS04875	COG1940	carbohydrate kinase activity
HV326_RS04880	COG0419	ATPase involved in DNA repair
HV326_RS04885	COG0420	3'-5' exonuclease activity
HV326_RS04895	COG5002	protein histidine kinase activity
HV326_RS04910	COG0366	Alpha amylase catalytic
HV326_RS04925	COG0450	alkyl hydroperoxide reductase
HV326_RS04930	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HV326_RS04945	COG1862	Preprotein translocase
HV326_RS04950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV326_RS04955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV326_RS04975	COG4238	major outer membrane lipoprotein
HV326_RS04980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HV326_RS04985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV326_RS04985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV326_RS04990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HV326_RS04995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HV326_RS05000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV326_RS05005	COG0667	Aldo Keto reductase
HV326_RS05010	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV326_RS05015	COG0142	geranyltranstransferase activity
HV326_RS05030	COG0693	protein deglycase activity
HV326_RS05035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HV326_RS05045	COG2814	Major facilitator Superfamily
HV326_RS05050	COG0235	Class ii aldolase
HV326_RS05070	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV326_RS05075	COG1129	ABC transporter
HV326_RS05095	COG0109	protoheme IX farnesyltransferase activity
HV326_RS05100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV326_RS05105	COG1845	cytochrome c oxidase, subunit III
HV326_RS05110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV326_RS05115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV326_RS05120	COG2223	nitrite transmembrane transporter activity
HV326_RS05125	COG3056	Lipoprotein
HV326_RS05130	COG0271	Belongs to the BolA IbaG family
HV326_RS05135	COG0544	peptidyl-prolyl cis-trans isomerase activity
HV326_RS05150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV326_RS05155	COG0776	regulation of translation
HV326_RS05160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV326_RS05165	COG1555	photosystem II stabilization
HV326_RS05170	COG0824	Thioesterase
HV326_RS05175	COG3657	addiction module killer protein
HV326_RS05185	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HV326_RS05190	COG4533	DNA binding
HV326_RS05195	COG0561	phosphatase activity
HV326_RS05205	COG1522	sequence-specific DNA binding
HV326_RS05210	COG1132	(ABC) transporter
HV326_RS05215	COG1132	(ABC) transporter
HV326_RS05220	COG0347	Belongs to the P(II) protein family
HV326_RS05225	COG0004	ammonium transporteR
HV326_RS05230	COG1946	Acyl-CoA thioesterase
HV326_RS05235	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV326_RS05240	COG3695	enzyme binding
HV326_RS05260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV326_RS05265	COG2364	Membrane
HV326_RS05270	COG1609	Transcriptional regulator
HV326_RS05290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV326_RS05300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HV326_RS05320	COG0110	maltose O-acetyltransferase activity
HV326_RS05335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV326_RS05340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV326_RS05345	COG1309	transcriptional regulator
HV326_RS05350	COG3264	Mechanosensitive ion channel
HV326_RS05350	COG1196	nuclear chromosome segregation
HV326_RS05360	COG3923	Primosomal replication protein n
HV326_RS05365	COG2832	Protein of unknown function (DUF454)
HV326_RS05370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HV326_RS05380	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HV326_RS05385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HV326_RS05390	COG0326	Molecular chaperone. Has ATPase activity
HV326_RS05400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HV326_RS05405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV326_RS05410	COG4651	solute:proton antiporter activity
HV326_RS05410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV326_RS05415	COG2223	nitrite transmembrane transporter activity
HV326_RS05420	COG0737	Belongs to the 5'-nucleotidase family
HV326_RS05425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV326_RS05430	COG3735	TraB family
HV326_RS05435	COG2217	Heavy metal translocating P-type atpase
HV326_RS05445	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV326_RS05450	COG0330	HflC and HflK could
HV326_RS05460	COG4619	ABC transporter
HV326_RS05465	COG0390	transport system, permease component
HV326_RS05470	COG3118	belongs to the thioredoxin family
HV326_RS05475	COG0300	oxidoreductase activity
HV326_RS05480	COG2755	lipolytic protein G-D-S-L family
HV326_RS05485	COG4181	ATPase activity
HV326_RS05490	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV326_RS05495	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV326_RS05505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV326_RS05510	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV326_RS05515	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV326_RS05520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV326_RS05535	COG1609	Transcriptional regulator
HV326_RS05540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV326_RS05540	COG2190	(PTS) system
HV326_RS05540	COG1263	PTS System
HV326_RS05545	COG2501	S4 domain
HV326_RS05590	COG1113	amino acid transport
HV326_RS05595	COG2211	Major facilitator Superfamily
HV326_RS05610	COG1609	Transcriptional regulator
HV326_RS05615	COG0668	transmembrane transport
HV326_RS05620	COG0477	Major facilitator Superfamily
HV326_RS05640	COG0778	Nitroreductase
HV326_RS05645	COG2315	Protein conserved in bacteria
HV326_RS05665	COG4774	siderophore transport
HV326_RS05695	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HV326_RS05745	COG4608	Belongs to the ABC transporter superfamily
HV326_RS05750	COG0444	Belongs to the ABC transporter superfamily
HV326_RS05760	COG0601	transmembrane transport
HV326_RS05790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV326_RS05805	COG1121	(ABC) transporter
HV326_RS05810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV326_RS05815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV326_RS05820	COG2977	Belongs to the P-Pant transferase superfamily
HV326_RS05825	COG4771	TonB-dependent receptor
HV326_RS05830	COG2382	esterase
HV326_RS05835	COG3251	PFAM MbtH domain protein
HV326_RS05840	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV326_RS05840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV326_RS05845	COG1120	ATPase activity
HV326_RS05850	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV326_RS05855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV326_RS05865	COG4592	Periplasmic binding protein
HV326_RS05870	COG1169	isochorismate synthase
HV326_RS05875	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV326_RS05880	COG3433	isochorismatase activity
HV326_RS05880	COG1535	isochorismatase
HV326_RS05885	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS05890	COG2050	protein possibly involved in aromatic compounds catabolism
HV326_RS05895	COG1966	Carbon starvation protein
HV326_RS05900	COG2879	small protein
HV326_RS05915	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS05920	COG0371	Dehydrogenase
HV326_RS05925	COG1129	ABC transporter
HV326_RS05930	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV326_RS05945	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HV326_RS05960	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HV326_RS05965	COG0235	Class ii aldolase
HV326_RS05970	COG0436	Aminotransferase
HV326_RS05975	COG1475	DNA binding
HV326_RS05980	COG3969	phosphoadenosine phosphosulfate
HV326_RS05985	COG0583	DNA-binding transcription factor activity
HV326_RS06005	COG0243	molybdopterin cofactor binding
HV326_RS06025	COG1063	alcohol dehydrogenase
HV326_RS06030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV326_RS06040	COG2207	Transcriptional regulator
HV326_RS06045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS06045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS06045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV326_RS06050	COG1363	Peptidase, m42
HV326_RS06055	COG0006	proline dipeptidase activity
HV326_RS06060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV326_RS06065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV326_RS06070	COG3719	Belongs to the RNase T2 family
HV326_RS06075	COG3069	C4-dicarboxylate transmembrane transporter activity
HV326_RS06100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV326_RS06105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HV326_RS06110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HV326_RS06130	COG0321	lipoyl(octanoyl) transferase activity
HV326_RS06140	COG1686	Belongs to the peptidase S11 family
HV326_RS06145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV326_RS06150	COG0772	Belongs to the SEDS family
HV326_RS06155	COG0768	penicillin binding
HV326_RS06165	COG0799	negative regulation of ribosome biogenesis
HV326_RS06175	COG1466	dna polymerase III delta subunit
HV326_RS06190	COG2888	peptidyl-tyrosine sulfation
HV326_RS06195	COG1957	nucleoside hydrolase
HV326_RS06200	COG1126	abc transporter atp-binding protein
HV326_RS06205	COG0765	amino acid transport
HV326_RS06210	COG0765	amino acid transport
HV326_RS06230	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV326_RS06235	COG1702	phosphate starvation-inducible protein PhoH
HV326_RS06240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HV326_RS06245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV326_RS06285	COG0367	asparagine synthase
HV326_RS06290	COG0647	UMP catabolic process
HV326_RS06295	COG1846	Transcriptional regulator
HV326_RS06295	COG1940	carbohydrate kinase activity
HV326_RS06300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV326_RS06310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV326_RS06310	COG2190	(PTS) system
HV326_RS06310	COG1263	PTS System
HV326_RS06330	COG0735	belongs to the Fur family
HV326_RS06350	COG0596	Alpha beta hydrolase
HV326_RS06355	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV326_RS06360	COG0033	Phosphoglucomutase
HV326_RS06365	COG0531	amino acid
HV326_RS06370	COG1982	Orn Lys Arg decarboxylase major
HV326_RS06380	COG0745	RESPONSE REGULATOR receiver
HV326_RS06385	COG2205	protein histidine kinase activity
HV326_RS06390	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HV326_RS06395	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HV326_RS06400	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HV326_RS06420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HV326_RS06425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV326_RS06430	COG1984	allophanate hydrolase subunit 2
HV326_RS06440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HV326_RS06445	COG0372	Belongs to the citrate synthase family
HV326_RS06450	COG2009	succinate dehydrogenase
HV326_RS06455	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV326_RS06460	COG1053	succinate dehydrogenase
HV326_RS06465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV326_RS06470	COG0567	Dehydrogenase, E1 component
HV326_RS06475	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV326_RS06480	COG0045	succinate-CoA ligase (ADP-forming) activity
HV326_RS06485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV326_RS06490	COG2188	Transcriptional regulator
HV326_RS06500	COG0383	alpha-mannosidase activity
HV326_RS06505	COG1271	oxidase subunit
HV326_RS06510	COG1294	oxidase, subunit
HV326_RS06515	COG4890	Cyd operon protein YbgT
HV326_RS06520	COG3790	cyd operon protein YbgE
HV326_RS06525	COG0824	Thioesterase
HV326_RS06530	COG0811	peptide transport
HV326_RS06535	COG0848	biopolymer transport protein
HV326_RS06540	COG3064	Membrane
HV326_RS06545	COG0823	Involved in the tonB-independent uptake of proteins
HV326_RS06550	COG2885	chlorophyll binding
HV326_RS06555	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV326_RS06590	COG3201	nicotinamide mononucleotide transporter
HV326_RS06595	COG1230	cation diffusion facilitator family transporter
HV326_RS06605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV326_RS06615	COG2017	converts alpha-aldose to the beta-anomer
HV326_RS06620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HV326_RS06625	COG1085	galactose-1-phosphate uridylyltransferase
HV326_RS06630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV326_RS06635	COG1119	ATPase activity
HV326_RS06640	COG3585	molybdate ion transport
HV326_RS06640	COG2005	Transcriptional regulator
HV326_RS06650	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV326_RS06655	COG4149	molybdate abc transporter
HV326_RS06665	COG0561	phosphatase activity
HV326_RS06670	COG2706	6-phosphogluconolactonase activity
HV326_RS06675	COG4677	pectinesterase activity
HV326_RS06685	COG0010	Belongs to the arginase family
HV326_RS06695	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HV326_RS06700	COG2986	histidine ammonia-lyase
HV326_RS06705	COG1881	PFAM PEBP family protein
HV326_RS06710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HV326_RS06715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HV326_RS06720	COG0156	8-amino-7-oxononanoate synthase activity
HV326_RS06725	COG2226	methyltransferase
HV326_RS06755	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV326_RS06760	COG0315	cyclic pyranopterin monophosphate synthase activity
HV326_RS06765	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV326_RS06770	COG0314	molybdopterin synthase activity
HV326_RS06775	COG0670	Belongs to the BI1 family
HV326_RS06780	COG0392	lysyltransferase activity
HV326_RS06785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV326_RS06790	COG3568	Endonuclease Exonuclease Phosphatase
HV326_RS06800	COG0842	Transport permease protein
HV326_RS06805	COG0842	Transport permease protein
HV326_RS06810	COG1131	(ABC) transporter
HV326_RS06815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV326_RS06820	COG1309	transcriptional regulator
HV326_RS06825	COG0513	Belongs to the DEAD box helicase family
HV326_RS06855	COG3539	Fimbrial protein
HV326_RS06860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV326_RS06870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV326_RS06880	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HV326_RS06885	COG0668	transmembrane transport
HV326_RS06890	COG1126	abc transporter atp-binding protein
HV326_RS06895	COG0765	amino acid transport
HV326_RS06900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV326_RS06905	COG0783	Belongs to the Dps family
HV326_RS06915	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV326_RS06920	COG2194	sulfuric ester hydrolase activity
HV326_RS06930	COG1321	iron dependent repressor
HV326_RS06935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV326_RS06940	COG1566	PFAM secretion protein HlyD family protein
HV326_RS06945	COG2814	Major facilitator Superfamily
HV326_RS06955	COG0667	Aldo Keto reductase
HV326_RS06960	COG2723	6-phospho-beta-galactosidase activity
HV326_RS06965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV326_RS06970	COG2188	Transcriptional regulator
HV326_RS06975	COG1376	ErfK ybiS ycfS ynhG family protein
HV326_RS06995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV326_RS07000	COG0488	(ABC) transporter
HV326_RS07010	COG2271	Major facilitator Superfamily
HV326_RS07015	COG1609	Transcriptional regulator
HV326_RS07025	COG0561	phosphatase activity
HV326_RS07030	COG1882	Formate acetyltransferase
HV326_RS07035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV326_RS07040	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV326_RS07050	COG0303	'Molybdopterin
HV326_RS07055	COG1446	asparaginase
HV326_RS07090	COG2133	pyrroloquinoline quinone binding
HV326_RS07095	COG0625	glutathione transferase activity
HV326_RS07100	COG1686	Belongs to the peptidase S11 family
HV326_RS07105	COG1349	DNA-binding transcription factor activity
HV326_RS07110	COG0671	phosphoesterase, PA-phosphatase related
HV326_RS07120	COG2814	Major facilitator Superfamily
HV326_RS07125	COG0561	phosphatase activity
HV326_RS07130	COG0738	Major facilitator superfamily
HV326_RS07135	COG3226	Transcriptional regulator
HV326_RS07140	COG1393	Belongs to the ArsC family
HV326_RS07145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV326_RS07150	COG0640	Transcriptional regulator
HV326_RS07170	COG0778	Nitroreductase
HV326_RS07185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV326_RS07190	COG3842	ATPase activity
HV326_RS07195	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV326_RS07200	COG1177	transmembrane transport
HV326_RS07210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV326_RS07215	COG0745	RESPONSE REGULATOR receiver
HV326_RS07220	COG5002	protein histidine kinase activity
HV326_RS07225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV326_RS07230	COG4160	amino acid transport
HV326_RS07235	COG4215	(ABC) transporter
HV326_RS07240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV326_RS07245	COG1126	abc transporter atp-binding protein
HV326_RS07255	COG0393	Putative heavy-metal-binding
HV326_RS07260	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV326_RS07280	COG3031	protein transport across the cell outer membrane
HV326_RS07285	COG1450	Type ii and iii secretion system protein
HV326_RS07290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV326_RS07295	COG1459	type II secretion system
HV326_RS07300	COG2165	general secretion pathway protein
HV326_RS07310	COG2165	general secretion pathway protein
HV326_RS07335	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HV326_RS07350	COG3397	chitin binding
HV326_RS07355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV326_RS07360	COG0702	epimerase
HV326_RS07365	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV326_RS07370	COG0028	Belongs to the TPP enzyme family
HV326_RS07375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV326_RS07380	COG1151	hydroxylamine reductase activity
HV326_RS07385	COG2431	L-lysine efflux transmembrane transporter activity
HV326_RS07395	COG3593	DNA synthesis involved in DNA repair
HV326_RS07400	COG2990	Protein conserved in bacteria
HV326_RS07405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV326_RS07415	COG1278	Cold shock
HV326_RS07420	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HV326_RS07425	COG0542	response to heat
HV326_RS07435	COG1518	maintenance of DNA repeat elements
HV326_RS07440	COG1203	CRISPR-associated helicase, Cas3
HV326_RS07465	COG5654	RES domain protein
HV326_RS07470	COG5642	Protein of unknown function (DUF2384)
HV326_RS07475	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV326_RS07480	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HV326_RS07485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV326_RS07490	COG4988	ABC transporter
HV326_RS07495	COG0492	ferredoxin-NADP+ reductase activity
HV326_RS07505	COG1178	ABC-type Fe3 transport system permease component
HV326_RS07505	COG1674	ftsk spoiiie
HV326_RS07510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HV326_RS07515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV326_RS07520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HV326_RS07530	COG0437	4 iron, 4 sulfur cluster binding
HV326_RS07535	COG3302	dmso reductase anchor subunit
HV326_RS07540	COG0477	Major facilitator Superfamily
HV326_RS07550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV326_RS07555	COG1882	Formate acetyltransferase
HV326_RS07560	COG2116	formate transmembrane transporter activity
HV326_RS07565	COG3039	Transposase
HV326_RS07570	COG1944	ATP diphosphatase activity
HV326_RS07575	COG2323	membrane
HV326_RS07580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HV326_RS07585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HV326_RS07590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HV326_RS07595	COG0539	negative regulation of cytoplasmic translation
HV326_RS07600	COG0776	regulation of translation
HV326_RS07610	COG1132	(ABC) transporter
HV326_RS07620	COG3214	Protein conserved in bacteria
HV326_RS07625	COG2835	tetraacyldisaccharide 4'-kinase activity
HV326_RS07630	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HV326_RS07635	COG3173	Aminoglycoside phosphotransferase
HV326_RS07640	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV326_RS07645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV326_RS07655	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV326_RS07660	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV326_RS07665	COG2989	Protein conserved in bacteria
HV326_RS07670	COG3108	Peptidase M15
HV326_RS07675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV326_RS07680	COG1448	Aminotransferase
HV326_RS07690	COG0017	Asparaginyl-tRNA synthetase
HV326_RS07695	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HV326_RS07700	COG0308	aminopeptidase N
HV326_RS07710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV326_RS07715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV326_RS07720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV326_RS07725	COG0431	NADPH-dependent FMN reductase
HV326_RS07730	COG0167	dihydroorotate dehydrogenase activity
HV326_RS07740	COG0633	Ferredoxin
HV326_RS07740	COG3217	Mosc domain protein beta barrel domain protein
HV326_RS07745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HV326_RS07745	COG0116	Belongs to the methyltransferase superfamily
HV326_RS07750	COG0488	(ABC) transporter
HV326_RS07755	COG2995	paraquat-inducible protein a
HV326_RS07760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV326_RS07760	COG3008	intermembrane lipid transfer
HV326_RS07765	COG3009	Protein conserved in bacteria
HV326_RS07770	COG3130	regulation of translation
HV326_RS07780	COG1067	ATP-dependent peptidase activity
HV326_RS07785	COG3120	sequence-specific DNA binding
HV326_RS07795	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HV326_RS07800	COG3070	regulator of competence-specific genes
HV326_RS07805	COG1289	transmembrane transporter activity
HV326_RS07810	COG3304	Inner membrane component domain
HV326_RS07815	COG0210	DNA helicase
HV326_RS07820	COG1803	Methylglyoxal synthase
HV326_RS07825	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HV326_RS07830	COG1832	CoA-binding protein
HV326_RS07840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HV326_RS07845	COG1254	Belongs to the acylphosphatase family
HV326_RS07855	COG0670	Belongs to the BI1 family
HV326_RS07870	COG1120	ATPase activity
HV326_RS07875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV326_RS07885	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HV326_RS07885	COG3264	Mechanosensitive ion channel
HV326_RS07900	COG2239	Acts as a magnesium transporter
HV326_RS07905	COG0586	Pfam SNARE associated Golgi protein
HV326_RS07910	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS07915	COG1733	regulation of RNA biosynthetic process
HV326_RS07935	COG3729	General stress protein
HV326_RS07955	COG2233	PERMEase
HV326_RS07960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV326_RS07965	COG0778	Nitroreductase
HV326_RS07970	COG2267	carboxylic ester hydrolase activity
HV326_RS07975	COG0251	oxidation-reduction process
HV326_RS07980	COG1335	isochorismatase
HV326_RS07985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV326_RS07990	COG1309	transcriptional regulator
HV326_RS08000	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV326_RS08000	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV326_RS08000	COG0506	proline dehydrogenase activity
HV326_RS08005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV326_RS08015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV326_RS08025	COG2822	iron ion transport
HV326_RS08035	COG1702	phosphate starvation-inducible protein PhoH
HV326_RS08045	COG1335	isochorismatase
HV326_RS08055	COG0583	DNA-binding transcription factor activity
HV326_RS08070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV326_RS08075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HV326_RS08080	COG3381	protein complex oligomerization
HV326_RS08130	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV326_RS08145	COG2943	transferase activity, transferring hexosyl groups
HV326_RS08150	COG5645	(Lipo)protein
HV326_RS08165	COG1560	Kdo2-lipid A biosynthetic process
HV326_RS08175	COG2353	YceI-like domain
HV326_RS08180	COG3038	cytochrome b561
HV326_RS08205	COG0418	dihydroorotase activity
HV326_RS08215	COG0477	Major facilitator Superfamily
HV326_RS08220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV326_RS08225	COG3132	Protein of unknown function, DUF480
HV326_RS08260	COG1558	bacterial-type flagellum-dependent cell motility
HV326_RS08270	COG1749	Flagellar hook protein flgE
HV326_RS08280	COG4786	Flagellar basal body rod
HV326_RS08300	COG1256	bacterial-type flagellum assembly
HV326_RS08310	COG2814	Major facilitator Superfamily
HV326_RS08315	COG0583	DNA-binding transcription factor activity
HV326_RS08320	COG1530	ribonuclease E activity
HV326_RS08325	COG0564	pseudouridine synthase activity
HV326_RS08340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HV326_RS08345	COG0416	fatty acid biosynthetic process
HV326_RS08350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HV326_RS08365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV326_RS08370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV326_RS08375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV326_RS08380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV326_RS08390	COG0470	DNA polymerase III
HV326_RS08395	COG0084	hydrolase, TatD family'
HV326_RS08405	COG4773	Receptor
HV326_RS08410	COG0537	adenosine 5'-monophosphoramidase activity
HV326_RS08415	COG5633	Lipoprotein
HV326_RS08420	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HV326_RS08435	COG3150	esterase
HV326_RS08440	COG1252	NADH dehydrogenase
HV326_RS08445	COG3134	Outer membrane lipoprotein
HV326_RS08450	COG1309	transcriptional regulator
HV326_RS08460	COG1376	ErfK ybiS ycfS ynhG family protein
HV326_RS08460	COG1388	LysM domain
HV326_RS08465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV326_RS08470	COG4763	Acyl-transferase
HV326_RS08475	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV326_RS08480	COG1136	(ABC) transporter
HV326_RS08485	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV326_RS08525	COG1943	Transposase
HV326_RS08530	COG2850	peptidyl-arginine hydroxylation
HV326_RS08535	COG2205	protein histidine kinase activity
HV326_RS08550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV326_RS08555	COG2915	High frequency lysogenization protein hflD homolog
HV326_RS08570	COG1187	pseudouridine synthase activity
HV326_RS08575	COG0538	isocitrate dehydrogenase activity
HV326_RS08585	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV326_RS08595	COG2261	transglycosylase associated protein
HV326_RS08610	COG2203	Gaf domain
HV326_RS08610	COG2199	diguanylate cyclase activity
HV326_RS08615	COG3042	response to heat
HV326_RS08625	COG3189	MarR family transcriptional regulator
HV326_RS08630	COG0504	CTP synthase activity
HV326_RS08635	COG2807	transmembrane transport
HV326_RS08640	COG2207	Transcriptional regulator
HV326_RS08645	COG2707	UPF0756 membrane protein
HV326_RS08660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV326_RS08665	COG2718	Belongs to the UPF0229 family
HV326_RS08670	COG2766	serine protein kinase
HV326_RS08675	COG3713	MltA-interacting MipA family protein
HV326_RS08695	COG3139	Protein of unknown function (DUF1315)
HV326_RS08705	COG1335	isochorismatase
HV326_RS08710	COG0252	asparaginase activity
HV326_RS08715	COG0616	signal peptide processing
HV326_RS08720	COG0778	Nitroreductase
HV326_RS08725	COG0709	Synthesizes selenophosphate from selenide and ATP
HV326_RS08730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV326_RS08745	COG0494	nUDIX hydrolase
HV326_RS08750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV326_RS08755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV326_RS08760	COG2897	thiosulfate sulfurtransferase activity
HV326_RS08765	COG4136	ATPase activity
HV326_RS08770	COG4135	transport system, permease component
HV326_RS08775	COG4134	Bacterial extracellular solute-binding protein
HV326_RS08785	COG0708	Exodeoxyribonuclease III
HV326_RS08795	COG3138	arginine N-succinyltransferase
HV326_RS08800	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS08805	COG3724	N-succinylarginine dihydrolase activity
HV326_RS08815	COG3678	ATP-independent chaperone mediated protein folding
HV326_RS08825	COG0322	excinuclease ABC activity
HV326_RS08835	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV326_RS08840	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV326_RS08845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV326_RS08850	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV326_RS08855	COG1917	Cupin 2, conserved barrel domain protein
HV326_RS08855	COG2169	Transcriptional regulator
HV326_RS08860	COG1486	melibiose metabolic process
HV326_RS08865	COG3394	polysaccharide catabolic process
HV326_RS08870	COG0753	catalase activity
HV326_RS08885	COG1988	membrane-bound metal-dependent
HV326_RS08890	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS08895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV326_RS08905	COG3001	Fructosamine kinase
HV326_RS08915	COG1105	Belongs to the carbohydrate kinase PfkB family
HV326_RS08920	COG3137	Salt-induced outer membrane protein
HV326_RS08965	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HV326_RS08970	COG0072	phenylalanine-tRNA ligase activity
HV326_RS08970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV326_RS08975	COG0776	regulation of translation
HV326_RS08985	COG0386	Belongs to the glutathione peroxidase family
HV326_RS08995	COG0791	NLP P60 protein
HV326_RS09005	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HV326_RS09015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV326_RS09020	COG4558	Periplasmic binding protein
HV326_RS09025	COG3720	iron ion transport
HV326_RS09035	COG4256	Hemin uptake protein
HV326_RS09040	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV326_RS09045	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HV326_RS09050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV326_RS09050	COG0574	Belongs to the PEP-utilizing enzyme family
HV326_RS09055	COG2211	Major facilitator Superfamily
HV326_RS09060	COG1472	Belongs to the glycosyl hydrolase 3 family
HV326_RS09070	COG0628	permease
HV326_RS09075	COG0247	lactate metabolic process
HV326_RS09075	COG0277	FAD linked oxidase domain protein
HV326_RS09080	COG2050	protein possibly involved in aromatic compounds catabolism
HV326_RS09090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV326_RS09105	COG3121	Chaperone
HV326_RS09120	COG3539	Fimbrial protein
HV326_RS09130	COG3383	formate dehydrogenase (NAD+) activity
HV326_RS09150	COG2200	EAL domain
HV326_RS09155	COG0789	Transcriptional regulator
HV326_RS09170	COG0316	Belongs to the HesB IscA family
HV326_RS09175	COG0719	Fe-S assembly protein
HV326_RS09180	COG0396	ATPase activity
HV326_RS09185	COG0719	Fe-S assembly protein
HV326_RS09190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV326_RS09195	COG2166	iron-sulfur cluster assembly
HV326_RS09200	COG1376	ErfK ybiS ycfS ynhG family protein
HV326_RS09215	COG0626	cystathionine gamma-synthase activity
HV326_RS09230	COG2011	ABC-type metal ion transport system permease component
HV326_RS09235	COG1464	Belongs to the NlpA lipoprotein family
HV326_RS09245	COG0765	amino acid transport
HV326_RS09250	COG0765	amino acid transport
HV326_RS09260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV326_RS09280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV326_RS09290	COG4529	Protein conserved in bacteria
HV326_RS09300	COG0071	Belongs to the small heat shock protein (HSP20) family
HV326_RS09320	COG0307	riboflavin synthase, alpha
HV326_RS09325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV326_RS09330	COG2814	Major facilitator Superfamily
HV326_RS09335	COG0583	DNA-binding transcription factor activity
HV326_RS09350	COG2814	Major facilitator Superfamily
HV326_RS09360	COG0791	NLP P60 protein
HV326_RS09365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV326_RS09375	COG0346	lactoylglutathione lyase activity
HV326_RS09380	COG1902	pentaerythritol trinitrate reductase activity
HV326_RS09385	COG1309	transcriptional regulator
HV326_RS09390	COG2194	sulfuric ester hydrolase activity
HV326_RS09395	COG3313	Fe-S protein
HV326_RS09400	COG4989	oxidoreductase activity
HV326_RS09405	COG2032	superoxide dismutase activity
HV326_RS09410	COG1289	transmembrane transporter activity
HV326_RS09415	COG1566	PFAM secretion protein HlyD family protein
HV326_RS09430	COG3706	GGDEF domain
HV326_RS09440	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HV326_RS09445	COG3895	Periplasmic Protein
HV326_RS09450	COG0259	pyridoxamine-phosphate oxidase activity
HV326_RS09455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HV326_RS09460	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV326_RS09465	COG0625	glutathione transferase activity
HV326_RS09470	COG3104	oligopeptide transport
HV326_RS09475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV326_RS09520	COG2801	Transposase and inactivated derivatives
HV326_RS09530	COG3111	PFAM Bacterial OB fold (BOF) protein
HV326_RS09545	COG2814	Major facilitator Superfamily
HV326_RS09595	COG3077	Addiction module antitoxin, RelB DinJ family
HV326_RS09600	COG2026	Addiction module toxin, RelE StbE family
HV326_RS09610	COG0673	inositol 2-dehydrogenase activity
HV326_RS09615	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HV326_RS09620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV326_RS09630	COG0582	viral genome integration into host DNA
HV326_RS09670	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV326_RS09685	COG0629	single-stranded DNA binding
HV326_RS09690	COG4712	double-strand break repair protein
HV326_RS09810	COG0484	heat shock protein binding
HV326_RS09860	COG1783	phage Terminase large subunit
HV326_RS09975	COG0463	Glycosyl transferase, family 2
HV326_RS09980	COG2246	polysaccharide biosynthetic process
HV326_RS09995	COG1609	Transcriptional regulator
HV326_RS10000	COG5339	Protein conserved in bacteria
HV326_RS10010	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV326_RS10010	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV326_RS10025	COG2205	protein histidine kinase activity
HV326_RS10035	COG1278	Cold shock
HV326_RS10045	COG0745	RESPONSE REGULATOR receiver
HV326_RS10050	COG3136	membrane protein required for alginate biosynthesis
HV326_RS10055	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS10060	COG0531	amino acid
HV326_RS10070	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV326_RS10075	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV326_RS10080	COG0668	transmembrane transport
HV326_RS10085	COG0589	response to stress
HV326_RS10095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV326_RS10100	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HV326_RS10105	COG1473	amidohydrolase
HV326_RS10115	COG0583	DNA-binding transcription factor activity
HV326_RS10120	COG2840	Smr protein MutS2
HV326_RS10130	COG0667	Aldo Keto reductase
HV326_RS10145	COG4993	Dehydrogenase
HV326_RS10185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV326_RS10190	COG1403	HNH endonuclease
HV326_RS10195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV326_RS10205	COG0628	permease
HV326_RS10210	COG2076	Multidrug Resistance protein
HV326_RS10215	COG2076	Multidrug Resistance protein
HV326_RS10220	COG3591	Belongs to the peptidase S1B family
HV326_RS10235	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV326_RS10240	COG2814	Major facilitator Superfamily
HV326_RS10245	COG0583	DNA-binding transcription factor activity
HV326_RS10250	COG1940	carbohydrate kinase activity
HV326_RS10255	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV326_RS10300	COG0583	DNA-binding transcription factor activity
HV326_RS10315	COG3141	response to X-ray
HV326_RS10320	COG3381	protein complex oligomerization
HV326_RS10325	COG3302	dmso reductase anchor subunit
HV326_RS10330	COG0437	4 iron, 4 sulfur cluster binding
HV326_RS10355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV326_RS10365	COG1742	UPF0060 membrane protein
HV326_RS10370	COG4948	Mandelate Racemase Muconate Lactonizing
HV326_RS10375	COG1063	alcohol dehydrogenase
HV326_RS10380	COG0477	Major facilitator Superfamily
HV326_RS10385	COG0246	Mannitol dehydrogenase
HV326_RS10395	COG0589	response to stress
HV326_RS10400	COG1802	Transcriptional regulator
HV326_RS10405	COG4221	oxidoreductase activity
HV326_RS10415	COG1683	Conserved Protein
HV326_RS10420	COG2135	peptidase activity
HV326_RS10430	COG0814	amino acid
HV326_RS10440	COG4993	Dehydrogenase
HV326_RS10465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV326_RS10470	COG2911	Protein conserved in bacteria
HV326_RS10480	COG3784	Protein of unknown function (DUF1318)
HV326_RS10485	COG2207	Transcriptional regulator
HV326_RS10490	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS10495	COG5001	Diguanylate cyclase
HV326_RS10495	COG4251	negative regulation of phosphorylation
HV326_RS10495	COG3706	GGDEF domain
HV326_RS10495	COG2203	Gaf domain
HV326_RS10500	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV326_RS10505	COG3733	amine oxidase
HV326_RS10525	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS10525	COG2030	dehydratase
HV326_RS10530	COG3396	Phenylacetate-CoA oxygenase
HV326_RS10535	COG3460	Phenylacetate-CoA oxygenase
HV326_RS10540	COG3396	Phenylacetate-CoA oxygenase
HV326_RS10545	COG2151	metal-sulfur cluster biosynthetic enzyme
HV326_RS10550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV326_RS10555	COG1024	Enoyl-CoA hydratase
HV326_RS10560	COG1024	Enoyl-CoA hydratase
HV326_RS10565	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV326_RS10570	COG2050	protein possibly involved in aromatic compounds catabolism
HV326_RS10575	COG0183	Belongs to the thiolase family
HV326_RS10580	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HV326_RS10585	COG3327	negative regulation of DNA-templated transcription, initiation
HV326_RS10590	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV326_RS10600	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV326_RS10620	COG0300	oxidoreductase activity
HV326_RS10635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV326_RS10680	COG3122	Protein conserved in bacteria
HV326_RS10685	COG0564	pseudouridine synthase activity
HV326_RS10695	COG1643	Atp-dependent helicase
HV326_RS10715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV326_RS10720	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS10725	COG3038	cytochrome b561
HV326_RS10730	COG0673	inositol 2-dehydrogenase activity
HV326_RS10735	COG1349	DNA-binding transcription factor activity
HV326_RS10750	COG2274	protein secretion by the type I secretion system
HV326_RS10825	COG0840	transmembrane signaling receptor activity
HV326_RS10830	COG0583	DNA-binding transcription factor activity
HV326_RS10835	COG5383	Protein conserved in bacteria
HV326_RS10840	COG2272	Belongs to the type-B carboxylesterase lipase family
HV326_RS10850	COG0436	Aminotransferase
HV326_RS10860	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HV326_RS10865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV326_RS10870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV326_RS10875	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV326_RS10880	COG0500	methyltransferase
HV326_RS10885	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV326_RS10890	COG0747	negative chemotaxis
HV326_RS10910	COG3135	benzoate transporter
HV326_RS10915	COG1396	sequence-specific DNA binding
HV326_RS10920	COG0826	peptidase U32
HV326_RS10945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV326_RS10965	COG1129	ABC transporter
HV326_RS10975	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV326_RS10980	COG2814	Major facilitator Superfamily
HV326_RS10985	COG0697	spore germination
HV326_RS11000	COG1846	Transcriptional regulator
HV326_RS11010	COG2814	Major facilitator Superfamily
HV326_RS11025	COG0583	DNA-binding transcription factor activity
HV326_RS11030	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS11040	COG2066	Belongs to the glutaminase family
HV326_RS11050	COG3706	GGDEF domain
HV326_RS11060	COG0246	Mannitol dehydrogenase
HV326_RS11065	COG3781	membrane
HV326_RS11085	COG0596	Alpha beta hydrolase
HV326_RS11090	COG0745	RESPONSE REGULATOR receiver
HV326_RS11110	COG0494	nUDIX hydrolase
HV326_RS11115	COG1349	DNA-binding transcription factor activity
HV326_RS11170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV326_RS11215	COG2814	Major facilitator Superfamily
HV326_RS11250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HV326_RS11260	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS11265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV326_RS11275	COG0583	DNA-binding transcription factor activity
HV326_RS11280	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV326_RS11285	COG4628	conserved protein (DUF2132)
HV326_RS11295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV326_RS11380	COG2200	EAL domain
HV326_RS11395	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV326_RS11400	COG0747	negative chemotaxis
HV326_RS11405	COG0601	transmembrane transport
HV326_RS11410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV326_RS11415	COG0444	Belongs to the ABC transporter superfamily
HV326_RS11420	COG4608	Belongs to the ABC transporter superfamily
HV326_RS11425	COG1764	response to oxidative stress
HV326_RS11455	COG0281	malic enzyme
HV326_RS11460	COG0488	(ABC) transporter
HV326_RS11465	COG1064	alcohol dehydrogenase
HV326_RS11475	COG1252	NADH dehydrogenase
HV326_RS11480	COG2814	Major facilitator Superfamily
HV326_RS11490	COG2864	formate dehydrogenase
HV326_RS11495	COG0437	4 iron, 4 sulfur cluster binding
HV326_RS11525	COG2223	nitrite transmembrane transporter activity
HV326_RS11530	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV326_RS11535	COG1140	nitrate reductase beta subunit
HV326_RS11540	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV326_RS11545	COG2181	nitrate reductase activity
HV326_RS11555	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV326_RS11560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV326_RS11565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HV326_RS11570	COG0640	Transcriptional regulator
HV326_RS11580	COG1560	Kdo2-lipid A biosynthetic process
HV326_RS11585	COG1942	4-Oxalocrotonate Tautomerase
HV326_RS11590	COG0625	glutathione transferase activity
HV326_RS11600	COG1126	abc transporter atp-binding protein
HV326_RS11615	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV326_RS11620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV326_RS11625	COG1473	amidohydrolase
HV326_RS11630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV326_RS11635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV326_RS11660	COG4772	TonB-dependent receptor
HV326_RS11665	COG1802	Transcriptional regulator
HV326_RS11670	COG2130	NADP-dependent
HV326_RS11680	COG1247	-acetyltransferase
HV326_RS11685	COG3238	Protein conserved in bacteria
HV326_RS11695	COG0747	negative chemotaxis
HV326_RS11725	COG3615	Tellurite resistance protein tehB
HV326_RS11730	COG3615	Tellurite resistance protein tehB
HV326_RS11740	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS11745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV326_RS11755	COG1271	oxidase subunit
HV326_RS11760	COG1294	oxidase, subunit
HV326_RS11770	COG3187	Heat shock protein
HV326_RS11775	COG3042	response to heat
HV326_RS11780	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV326_RS11780	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV326_RS11780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV326_RS11780	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV326_RS11785	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV326_RS11805	COG0582	viral genome integration into host DNA
HV326_RS11815	COG0513	Belongs to the DEAD box helicase family
HV326_RS11830	COG0840	transmembrane signaling receptor activity
HV326_RS11930	COG2885	chlorophyll binding
HV326_RS11955	COG4166	transmembrane transport
HV326_RS11960	COG2866	Carboxypeptidase
HV326_RS11965	COG4948	Mandelate Racemase Muconate Lactonizing
HV326_RS11970	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV326_RS11980	COG3768	UPF0283 membrane protein
HV326_RS11985	COG3106	COG3106 Predicted ATPase
HV326_RS11990	COG1609	Transcriptional regulator
HV326_RS12000	COG3842	ATPase activity
HV326_RS12005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV326_RS12010	COG1554	hydrolase, family 65, central catalytic
HV326_RS12015	COG0673	inositol 2-dehydrogenase activity
HV326_RS12020	COG1082	Xylose isomerase domain protein TIM barrel
HV326_RS12025	COG1063	alcohol dehydrogenase
HV326_RS12030	COG0395	ABC-type sugar transport system, permease component
HV326_RS12035	COG1175	transmembrane transport
HV326_RS12040	COG1653	transport
HV326_RS12045	COG0366	Alpha amylase catalytic
HV326_RS12055	COG1983	PspC domain protein
HV326_RS12065	COG1842	Phage shock protein A
HV326_RS12070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV326_RS12085	COG4171	peptide transport system, permease
HV326_RS12095	COG4172	Belongs to the ABC transporter superfamily
HV326_RS12105	COG0251	oxidation-reduction process
HV326_RS12110	COG2207	Transcriptional regulator
HV326_RS12110	COG3708	Transcriptional regulator
HV326_RS12115	COG3706	GGDEF domain
HV326_RS12120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV326_RS12125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV326_RS12125	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV326_RS12135	COG5001	Diguanylate cyclase
HV326_RS12140	COG1024	Enoyl-CoA hydratase
HV326_RS12150	COG1349	DNA-binding transcription factor activity
HV326_RS12160	COG0023	Translation Initiation Factor
HV326_RS12165	COG0284	orotidine-5'-phosphate decarboxylase activity
HV326_RS12170	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV326_RS12175	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV326_RS12180	COG0671	phosphoesterase, PA-phosphatase related
HV326_RS12190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV326_RS12220	COG0616	signal peptide processing
HV326_RS12225	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS12230	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HV326_RS12240	COG0009	L-threonylcarbamoyladenylate synthase
HV326_RS12260	COG0512	Glutamine amidotransferase of anthranilate synthase
HV326_RS12260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV326_RS12270	COG0133	tryptophan synthase activity
HV326_RS12275	COG0159	tryptophan synthase activity
HV326_RS12285	COG0425	Belongs to the sulfur carrier protein TusA family
HV326_RS12290	COG3047	cAMP biosynthetic process
HV326_RS12295	COG0727	PFAM Uncharacterised protein family (UPF0153)
HV326_RS12325	COG2350	Protein conserved in bacteria
HV326_RS12330	COG1280	lysine exporter protein (LysE YggA)
HV326_RS12350	COG3099	Belongs to the UPF0263 family
HV326_RS12355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV326_RS12360	COG4608	Belongs to the ABC transporter superfamily
HV326_RS12365	COG0444	Belongs to the ABC transporter superfamily
HV326_RS12385	COG2095	MarC family integral membrane protein
HV326_RS12390	COG1454	alcohol dehydrogenase
HV326_RS12390	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS12395	COG1435	thymidine kinase activity
HV326_RS12405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV326_RS12410	COG0745	RESPONSE REGULATOR receiver
HV326_RS12415	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV326_RS12420	COG3012	SEC-C Motif Domain Protein
HV326_RS12425	COG0788	formyltetrahydrofolate deformylase activity
HV326_RS12440	COG2181	nitrate reductase activity
HV326_RS12445	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV326_RS12450	COG1140	nitrate reductase beta subunit
HV326_RS12455	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV326_RS12460	COG2223	nitrite transmembrane transporter activity
HV326_RS12465	COG3850	Histidine kinase
HV326_RS12470	COG2197	response regulator
HV326_RS12475	COG4932	domain protein
HV326_RS12480	COG0243	molybdopterin cofactor binding
HV326_RS12485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV326_RS12485	COG2146	nitrite reductase [NAD(P)H] activity
HV326_RS12490	COG1116	anion transmembrane transporter activity
HV326_RS12500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV326_RS12505	COG3707	response regulator
HV326_RS12510	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV326_RS12515	COG0840	transmembrane signaling receptor activity
HV326_RS12525	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV326_RS12530	COG4572	Cation transport regulator
HV326_RS12535	COG0387	Pfam Sodium calcium exchanger
HV326_RS12540	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HV326_RS12555	COG2890	protein-(glutamine-N5) methyltransferase activity
HV326_RS12565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HV326_RS12575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HV326_RS12585	COG0659	secondary active sulfate transmembrane transporter activity
HV326_RS12600	COG0193	aminoacyl-tRNA hydrolase activity
HV326_RS12605	COG0012	GTP binding
HV326_RS12655	COG3501	Rhs element vgr protein
HV326_RS12670	COG0515	serine threonine protein kinase
HV326_RS12685	COG4774	siderophore transport
HV326_RS12695	COG0741	lytic transglycosylase activity
HV326_RS12700	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV326_RS12705	COG3263	regulation of cellular component size
HV326_RS12710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV326_RS12715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV326_RS12720	COG2719	SpoVR family
HV326_RS12730	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV326_RS12740	COG2983	Belongs to the UPF0260 family
HV326_RS12745	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV326_RS12755	COG0850	regulation of cytokinetic process
HV326_RS12760	COG2894	cell division
HV326_RS12765	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HV326_RS12770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV326_RS12775	COG0318	PFAM AMP-dependent synthetase and ligase
HV326_RS12780	COG3065	identical protein binding
HV326_RS12785	COG1214	PFAM Peptidase M22, glycoprotease
HV326_RS12790	COG1199	ATP-dependent helicase activity
HV326_RS12795	COG0251	oxidation-reduction process
HV326_RS12810	COG0494	nUDIX hydrolase
HV326_RS12815	COG1760	l-serine dehydratase
HV326_RS12820	COG2200	EAL domain
HV326_RS12825	COG1253	flavin adenine dinucleotide binding
HV326_RS12830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV326_RS12830	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS12835	COG3715	PTS system
HV326_RS12840	COG3716	PTS system mannose fructose sorbose family IID component
HV326_RS12845	COG4811	Protein of unknown function (DUF986)
HV326_RS12850	COG1971	Probably functions as a manganese efflux pump
HV326_RS12855	COG2226	methyltransferase
HV326_RS12860	COG0768	penicillin binding
HV326_RS12890	COG1414	Transcriptional regulator
HV326_RS12895	COG2814	Major facilitator Superfamily
HV326_RS12900	COG0501	Belongs to the peptidase M48B family
HV326_RS12910	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HV326_RS12915	COG1956	GAF domain-containing protein
HV326_RS12920	COG2995	paraquat-inducible protein a
HV326_RS12925	COG3008	intermembrane lipid transfer
HV326_RS12930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HV326_RS12930	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HV326_RS12945	COG2990	Protein conserved in bacteria
HV326_RS12960	COG1276	copper resistance
HV326_RS12965	COG2372	response to copper ion
HV326_RS12975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV326_RS12980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV326_RS12985	COG1770	oligopeptidase
HV326_RS12990	COG2979	Protein of unknown function (DUF533)
HV326_RS13000	COG0800	Aldolase
HV326_RS13005	COG0129	dihydroxy-acid dehydratase activity
HV326_RS13010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV326_RS13015	COG1737	Transcriptional regulator
HV326_RS13025	COG1560	Kdo2-lipid A biosynthetic process
HV326_RS13030	COG0739	heme binding
HV326_RS13035	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV326_RS13045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV326_RS13050	COG2255	four-way junction helicase activity
HV326_RS13055	COG0632	four-way junction helicase activity
HV326_RS13070	COG0494	nUDIX hydrolase
HV326_RS13080	COG1335	isochorismatase
HV326_RS13095	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV326_RS13195	COG0740	serine-type endopeptidase activity
HV326_RS13200	COG4695	Portal protein
HV326_RS13205	COG4626	Terminase
HV326_RS13205	COG1802	Transcriptional regulator
HV326_RS13235	COG0582	viral genome integration into host DNA
HV326_RS13240	COG1801	Protein of unknown function DUF72
HV326_RS13245	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV326_RS13250	COG2226	methyltransferase
HV326_RS13255	COG0500	methyltransferase
HV326_RS13260	COG3142	Participates in the control of copper homeostasis
HV326_RS13265	COG3102	Protein conserved in bacteria
HV326_RS13270	COG0018	arginyl-trna synthetase
HV326_RS13275	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV326_RS13300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HV326_RS13315	COG0745	RESPONSE REGULATOR receiver
HV326_RS13330	COG0840	transmembrane signaling receptor activity
HV326_RS13365	COG1301	dicarboxylic acid transport
HV326_RS13405	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HV326_RS13415	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV326_RS13425	COG1879	ABC-type sugar transport system periplasmic component
HV326_RS13435	COG1528	Iron-storage protein
HV326_RS13440	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV326_RS13470	COG1528	Iron-storage protein
HV326_RS13480	COG0814	amino acid
HV326_RS13485	COG3318	Belongs to the UPF0149 family
HV326_RS13485	COG3012	SEC-C Motif Domain Protein
HV326_RS13520	COG0583	DNA-binding transcription factor activity
HV326_RS13550	COG2197	response regulator
HV326_RS13560	COG2197	response regulator
HV326_RS13595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV326_RS13600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV326_RS13605	COG1516	flagellar protein fliS
HV326_RS13615	COG0366	Alpha amylase catalytic
HV326_RS13625	COG1677	Flagellar hook-basal body complex protein FliE
HV326_RS13635	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HV326_RS13645	COG1157	protein secretion by the type III secretion system
HV326_RS13685	COG1987	bacterial-type flagellum assembly
HV326_RS13695	COG2197	response regulator
HV326_RS13720	COG5475	Uncharacterized small protein (DUF2158)
HV326_RS13725	COG2354	Protein conserved in bacteria
HV326_RS13730	COG0697	spore germination
HV326_RS13735	COG3727	T/G mismatch-specific endonuclease activity
HV326_RS13740	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV326_RS13745	COG1418	mRNA catabolic process
HV326_RS13750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV326_RS13760	COG3290	protein histidine kinase activity
HV326_RS13765	COG4565	transcriptional regulatory protein
HV326_RS13785	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV326_RS13785	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV326_RS13810	COG0583	DNA-binding transcription factor activity
HV326_RS13860	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HV326_RS13885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HV326_RS13890	COG0589	response to stress
HV326_RS13900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV326_RS13915	COG0477	Major facilitator Superfamily
HV326_RS13920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV326_RS13930	COG0534	Mate efflux family protein
HV326_RS13945	COG1289	transmembrane transporter activity
HV326_RS13950	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV326_RS13960	COG2925	Exonuclease
HV326_RS13965	COG0531	amino acid
HV326_RS13975	COG0583	DNA-binding transcription factor activity
HV326_RS13980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV326_RS13990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HV326_RS14000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV326_RS14005	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV326_RS14005	COG0131	Imidazoleglycerol-phosphate dehydratase
HV326_RS14010	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV326_RS14015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HV326_RS14020	COG0107	imidazoleglycerol-phosphate synthase activity
HV326_RS14050	COG1088	dTDP-glucose 4,6-dehydratase activity
HV326_RS14055	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HV326_RS14070	COG0438	transferase activity, transferring glycosyl groups
HV326_RS14085	COG1216	Glycosyl transferase, family 2
HV326_RS14085	COG0463	Glycosyl transferase, family 2
HV326_RS14095	COG0438	transferase activity, transferring glycosyl groups
HV326_RS14105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV326_RS14115	COG0438	transferase activity, transferring glycosyl groups
HV326_RS14120	COG2327	Polysaccharide pyruvyl transferase
HV326_RS14125	COG2244	polysaccharide biosynthetic process
HV326_RS14130	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV326_RS14135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV326_RS14145	COG0297	glycogen (starch) synthase activity
HV326_RS14150	COG1051	belongs to the nudix hydrolase family
HV326_RS14155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV326_RS14160	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV326_RS14165	COG0110	maltose O-acetyltransferase activity
HV326_RS14170	COG1216	Glycosyl transferase, family 2
HV326_RS14180	COG0438	transferase activity, transferring glycosyl groups
HV326_RS14185	COG1045	serine acetyltransferase
HV326_RS14190	COG0463	Glycosyl transferase, family 2
HV326_RS14195	COG0489	protein tyrosine kinase activity
HV326_RS14195	COG3206	protein involved in exopolysaccharide biosynthesis
HV326_RS14210	COG1253	flavin adenine dinucleotide binding
HV326_RS14215	COG2982	Protein involved in outer membrane biogenesis
HV326_RS14220	COG0717	Belongs to the dCTP deaminase family
HV326_RS14230	COG3447	MASE1 domain protein
HV326_RS14230	COG5002	protein histidine kinase activity
HV326_RS14230	COG5001	Diguanylate cyclase
HV326_RS14235	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV326_RS14240	COG0443	Heat shock 70 kDa protein
HV326_RS14245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV326_RS14250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV326_RS14255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV326_RS14260	COG0477	Major facilitator Superfamily
HV326_RS14265	COG2205	protein histidine kinase activity
HV326_RS14270	COG0745	RESPONSE REGULATOR receiver
HV326_RS14285	COG1597	lipid kinase activity
HV326_RS14290	COG1830	Aldolase
HV326_RS14295	COG2211	Major facilitator Superfamily
HV326_RS14300	COG1397	ADP-ribosylglycohydrolase
HV326_RS14305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV326_RS14310	COG2188	Transcriptional regulator
HV326_RS14315	COG0351	phosphomethylpyrimidine kinase
HV326_RS14320	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HV326_RS14335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV326_RS14340	COG0076	glutamate decarboxylase activity
HV326_RS14345	COG3206	protein involved in exopolysaccharide biosynthesis
HV326_RS14345	COG0489	protein tyrosine kinase activity
HV326_RS14350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HV326_RS14355	COG1596	polysaccharide export
HV326_RS14365	COG5455	response to cobalt ion
HV326_RS14375	COG0489	protein tyrosine kinase activity
HV326_RS14385	COG4807	Protein conserved in bacteria
HV326_RS14390	COG3279	Response regulator of the LytR AlgR family
HV326_RS14395	COG3275	phosphorelay sensor kinase activity
HV326_RS14400	COG0789	Transcriptional regulator
HV326_RS14410	COG1174	glycine betaine transport
HV326_RS14415	COG1125	glycine betaine transport
HV326_RS14420	COG1174	glycine betaine transport
HV326_RS14425	COG1732	Glycine betaine
HV326_RS14430	COG1472	Belongs to the glycosyl hydrolase 3 family
HV326_RS14435	COG0277	FAD linked oxidase domain protein
HV326_RS14445	COG1686	Belongs to the peptidase S11 family
HV326_RS14455	COG0586	Pfam SNARE associated Golgi protein
HV326_RS14460	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS14465	COG1538	Outer membrane efflux protein
HV326_RS14470	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV326_RS14480	COG1346	cytolysis
HV326_RS14485	COG0295	cytidine deaminase activity
HV326_RS14490	COG2949	membrane
HV326_RS14510	COG1129	ABC transporter
HV326_RS14525	COG2311	Membrane
HV326_RS14535	COG0477	Major facilitator Superfamily
HV326_RS14540	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HV326_RS14545	COG4771	TonB-dependent receptor
HV326_RS14550	COG0833	amino acid
HV326_RS14555	COG0583	DNA-binding transcription factor activity
HV326_RS14560	COG2855	membrane
HV326_RS14565	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HV326_RS14570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV326_RS14570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV326_RS14570	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV326_RS14575	COG1105	Belongs to the carbohydrate kinase PfkB family
HV326_RS14580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS14580	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS14600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV326_RS14690	COG1312	Catalyzes the dehydration of D-mannonate
HV326_RS14695	COG0246	Mannitol dehydrogenase
HV326_RS14700	COG0523	cobalamin synthesis protein
HV326_RS14705	COG0671	phosphoesterase, PA-phosphatase related
HV326_RS14710	COG0791	NLP P60 protein
HV326_RS14715	COG2200	EAL domain
HV326_RS14720	COG4166	transmembrane transport
HV326_RS14725	COG4174	ABC transporter (Permease)
HV326_RS14730	COG4239	(ABC) transporter, permease
HV326_RS14735	COG4172	Belongs to the ABC transporter superfamily
HV326_RS14745	COG2814	Major facilitator Superfamily
HV326_RS14750	COG1187	pseudouridine synthase activity
HV326_RS14755	COG1061	Type III restriction enzyme res subunit
HV326_RS14765	COG3081	Nucleoid-associated protein
HV326_RS14770	COG3082	Protein of unknown function (DUF1414)
HV326_RS14785	COG3182	Iron-regulated membrane protein
HV326_RS14795	COG0579	oxidoreductase
HV326_RS14800	COG0659	secondary active sulfate transmembrane transporter activity
HV326_RS14805	COG2239	Acts as a magnesium transporter
HV326_RS14810	COG4615	Cyclic peptide transporter
HV326_RS14820	COG2169	Transcriptional regulator
HV326_RS14820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV326_RS14835	COG0642	Histidine kinase
HV326_RS14835	COG2198	Histidine kinase
HV326_RS14855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV326_RS14870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV326_RS14875	COG0584	glycerophosphoryl diester phosphodiesterase
HV326_RS14880	COG2271	Major facilitator Superfamily
HV326_RS14885	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV326_RS14890	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HV326_RS14895	COG0247	lactate metabolic process
HV326_RS14910	COG0642	Histidine kinase
HV326_RS14940	COG1441	menaquinone biosynthetic process
HV326_RS14950	COG0596	Alpha beta hydrolase
HV326_RS14955	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HV326_RS14960	COG1169	isochorismate synthase
HV326_RS14965	COG4575	ribosome binding
HV326_RS14970	COG2153	protein acetylation
HV326_RS14975	COG1234	tRNA 3'-trailer cleavage
HV326_RS14980	COG0784	Response regulator, receiver
HV326_RS14980	COG0835	chemotaxis
HV326_RS14985	COG1007	ATP synthesis coupled electron transport
HV326_RS14990	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV326_RS14995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV326_RS15000	COG0713	ATP synthesis coupled electron transport
HV326_RS15005	COG0839	Belongs to the complex I subunit 6 family
HV326_RS15015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HV326_RS15045	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV326_RS15050	COG0583	DNA-binding transcription factor activity
HV326_RS15055	COG0436	Aminotransferase
HV326_RS15065	COG0490	domain, Protein
HV326_RS15065	COG0471	metal ion transport
HV326_RS15070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV326_RS15095	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV326_RS15100	COG3959	Transketolase, thiamine diphosphate binding domain
HV326_RS15105	COG3037	sugar-specific permease SgaT UlaA
HV326_RS15115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS15120	COG1609	Transcriptional regulator
HV326_RS15130	COG0622	Phosphoesterase
HV326_RS15135	COG0625	glutathione transferase activity
HV326_RS15140	COG0625	glutathione transferase activity
HV326_RS15145	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV326_RS15150	COG1090	epimerase
HV326_RS15155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV326_RS15160	COG4598	ABC transporter
HV326_RS15165	COG4160	amino acid transport
HV326_RS15175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV326_RS15185	COG0163	prenyltransferase activity
HV326_RS15190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV326_RS15195	COG1286	toxin biosynthetic process
HV326_RS15200	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV326_RS15205	COG0285	dihydrofolate synthase activity
HV326_RS15215	COG0586	Pfam SNARE associated Golgi protein
HV326_RS15220	COG0101	tRNA pseudouridine synthase activity
HV326_RS15225	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV326_RS15230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV326_RS15245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV326_RS15250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HV326_RS15250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV326_RS15260	COG3101	peptidyl-lysine hydroxylation
HV326_RS15265	COG0730	response to heat
HV326_RS15285	COG2840	Smr protein MutS2
HV326_RS15290	COG2062	phosphohistidine phosphatase, SixA
HV326_RS15295	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV326_RS15295	COG1024	Enoyl-CoA hydratase
HV326_RS15305	COG3691	Protein conserved in bacteria
HV326_RS15310	COG2067	long-chain fatty acid transport protein
HV326_RS15320	COG2116	formate transmembrane transporter activity
HV326_RS15330	COG3706	GGDEF domain
HV326_RS15335	COG1560	Kdo2-lipid A biosynthetic process
HV326_RS15345	COG0436	Aminotransferase
HV326_RS15350	COG3275	phosphorelay sensor kinase activity
HV326_RS15355	COG3279	Response regulator of the LytR AlgR family
HV326_RS15360	COG0837	glucose binding
HV326_RS15370	COG3961	Belongs to the TPP enzyme family
HV326_RS15375	COG0667	Aldo Keto reductase
HV326_RS15385	COG1914	H( )-stimulated, divalent metal cation uptake system
HV326_RS15390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV326_RS15395	COG2200	EAL domain
HV326_RS15395	COG2199	diguanylate cyclase activity
HV326_RS15410	COG3415	Transposase
HV326_RS15415	COG3415	Transposase
HV326_RS15420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HV326_RS15450	COG0583	DNA-binding transcription factor activity
HV326_RS15455	COG0385	Bile acid
HV326_RS15460	COG3530	Putative quorum-sensing-regulated virulence factor
HV326_RS15465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HV326_RS15470	COG3115	cell septum assembly
HV326_RS15485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS15510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV326_RS15515	COG4208	sulfate ABC transporter
HV326_RS15520	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV326_RS15525	COG4150	thiosulfate binding
HV326_RS15530	COG2837	iron assimilation
HV326_RS15555	COG0408	coproporphyrinogen oxidase activity
HV326_RS15570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV326_RS15575	COG5342	invasion associated locus B
HV326_RS15580	COG0494	nUDIX hydrolase
HV326_RS15585	COG0493	'glutamate synthase
HV326_RS15585	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV326_RS15590	COG3850	Histidine kinase
HV326_RS15595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV326_RS15605	COG1393	Belongs to the ArsC family
HV326_RS15610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV326_RS15620	COG0400	carboxylic ester hydrolase activity
HV326_RS15630	COG2321	neutral zinc metallopeptidase
HV326_RS15635	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HV326_RS15640	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV326_RS15650	COG2716	regulation of RNA biosynthetic process
HV326_RS15655	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV326_RS15660	COG0628	permease
HV326_RS15665	COG4783	chaperone-mediated protein folding
HV326_RS15670	COG1393	Belongs to the ArsC family
HV326_RS15685	COG1446	asparaginase
HV326_RS15690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV326_RS15700	COG2233	PERMEase
HV326_RS15705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HV326_RS15710	COG2723	6-phospho-beta-galactosidase activity
HV326_RS15720	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV326_RS15735	COG2200	EAL domain
HV326_RS15750	COG3713	MltA-interacting MipA family protein
HV326_RS15755	COG0745	RESPONSE REGULATOR receiver
HV326_RS15775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV326_RS15790	COG3179	chitinase
HV326_RS15805	COG2246	polysaccharide biosynthetic process
HV326_RS15810	COG0463	Glycosyl transferase, family 2
HV326_RS15930	COG3728	DNA packaging
HV326_RS15930	COG5484	DNA packaging
HV326_RS16020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV326_RS16060	COG0516	GMP reductase activity
HV326_RS16060	COG0517	IMP dehydrogenase activity
HV326_RS16065	COG1570	exodeoxyribonuclease VII activity
HV326_RS16080	COG1645	bacterial-type flagellum-dependent swarming motility
HV326_RS16085	COG3104	oligopeptide transport
HV326_RS16090	COG1160	GTP binding
HV326_RS16100	COG2976	Protein conserved in bacteria
HV326_RS16105	COG0124	histidyl-tRNA synthetase
HV326_RS16110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HV326_RS16120	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HV326_RS16130	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV326_RS16140	COG0437	4 iron, 4 sulfur cluster binding
HV326_RS16145	COG0243	molybdopterin cofactor binding
HV326_RS16150	COG4953	penicillin-binding protein 1C
HV326_RS16155	COG2373	Large extracellular alpha-helical protein
HV326_RS16160	COG1263	PTS System
HV326_RS16160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV326_RS16160	COG2190	(PTS) system
HV326_RS16170	COG2897	thiosulfate sulfurtransferase activity
HV326_RS16175	COG1737	Transcriptional regulator
HV326_RS16185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV326_RS16190	COG2975	iron-sulfur cluster assembly
HV326_RS16195	COG0633	Ferredoxin
HV326_RS16200	COG0443	Heat shock 70 kDa protein
HV326_RS16205	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HV326_RS16210	COG0316	Belongs to the HesB IscA family
HV326_RS16215	COG0822	iron-sulfur transferase activity
HV326_RS16220	COG1104	cysteine desulfurase activity
HV326_RS16240	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV326_RS16250	COG3711	transcriptional antiterminator
HV326_RS16255	COG2814	Major facilitator Superfamily
HV326_RS16260	COG2259	Doxx family
HV326_RS16270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV326_RS16270	COG1017	nitric oxide dioxygenase activity
HV326_RS16275	COG0347	Belongs to the P(II) protein family
HV326_RS16280	COG2204	response regulator
HV326_RS16285	COG3170	Tfp pilus assembly protein FimV
HV326_RS16290	COG2205	protein histidine kinase activity
HV326_RS16295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HV326_RS16295	COG0047	phosphoribosylformylglycinamidine synthase activity
HV326_RS16300	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV326_RS16310	COG0560	Phosphoserine phosphatase
HV326_RS16315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV326_RS16315	COG1263	PTS System
HV326_RS16320	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV326_RS16325	COG1737	Transcriptional regulator
HV326_RS16330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV326_RS16340	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV326_RS16345	COG1381	Involved in DNA repair and RecF pathway recombination
HV326_RS16360	COG0681	Belongs to the peptidase S26 family
HV326_RS16370	COG3086	response to oxidative stress
HV326_RS16380	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HV326_RS16390	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV326_RS16395	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HV326_RS16400	COG0513	Belongs to the DEAD box helicase family
HV326_RS16405	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HV326_RS16410	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HV326_RS16415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV326_RS16420	COG3118	belongs to the thioredoxin family
HV326_RS16430	COG0045	succinate-CoA ligase (ADP-forming) activity
HV326_RS16430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV326_RS16430	COG1042	CoA-binding domain protein
HV326_RS16435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV326_RS16440	COG5544	Lipoprotein
HV326_RS16445	COG0477	Major facilitator Superfamily
HV326_RS16475	COG0542	response to heat
HV326_RS16485	COG0564	pseudouridine synthase activity
HV326_RS16490	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV326_RS16495	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV326_RS16505	COG1605	Chorismate mutase
HV326_RS16505	COG0077	Prephenate dehydratase
HV326_RS16515	COG0287	Prephenate dehydrogenase
HV326_RS16515	COG1605	Chorismate mutase
HV326_RS16520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV326_RS16535	COG2199	diguanylate cyclase activity
HV326_RS16540	COG2885	chlorophyll binding
HV326_RS16560	COG0336	Belongs to the RNA methyltransferase TrmD family
HV326_RS16565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HV326_RS16575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV326_RS16580	COG4137	Cytochrome C assembly protein
HV326_RS16585	COG4536	flavin adenine dinucleotide binding
HV326_RS16595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HV326_RS16600	COG0497	DNA recombination
HV326_RS16615	COG2867	negative regulation of translational initiation
HV326_RS16630	COG0582	viral genome integration into host DNA
HV326_RS16640	COG3311	Transcriptional regulator
HV326_RS16655	COG4735	regulation of single-species biofilm formation
HV326_RS16685	COG2003	Belongs to the UPF0758 family
HV326_RS16705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV326_RS16710	COG4209	transmembrane transport
HV326_RS16715	COG0395	ABC-type sugar transport system, permease component
HV326_RS16730	COG3842	ATPase activity
HV326_RS16740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HV326_RS16760	COG2814	Major facilitator Superfamily
HV326_RS16765	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HV326_RS16770	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS16775	COG1073	alpha beta
HV326_RS16775	COG2226	methyltransferase
HV326_RS16860	COG3250	beta-galactosidase activity
HV326_RS16870	COG4221	oxidoreductase activity
HV326_RS16895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV326_RS16900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV326_RS16915	COG0402	S-adenosylhomocysteine deaminase activity
HV326_RS16920	COG0549	Belongs to the carbamate kinase family
HV326_RS16930	COG1304	FMN binding
HV326_RS16935	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV326_RS16940	COG0666	response to abiotic stimulus
HV326_RS16945	COG0583	DNA-binding transcription factor activity
HV326_RS16950	COG0401	homolog of Blt101
HV326_RS16955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV326_RS16970	COG3039	Transposase
HV326_RS16990	COG4575	ribosome binding
HV326_RS17000	COG1780	Probably involved in ribonucleotide reductase function
HV326_RS17005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV326_RS17015	COG4175	Glycine betaine
HV326_RS17020	COG4176	ABC-type proline glycine betaine transport system permease component
HV326_RS17030	COG2814	Major facilitator Superfamily
HV326_RS17035	COG1846	Transcriptional regulator
HV326_RS17040	COG1566	PFAM secretion protein HlyD family protein
HV326_RS17045	COG2814	Major facilitator Superfamily
HV326_RS17050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HV326_RS17065	COG2918	glutathione biosynthetic process
HV326_RS17070	COG1238	metal cluster binding
HV326_RS17075	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV326_RS17105	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV326_RS17110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HV326_RS17125	COG1546	Belongs to the CinA family
HV326_RS17135	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV326_RS17145	COG2951	lytic endotransglycosylase activity
HV326_RS17150	COG3730	PTS system glucitol sorbitol-specific
HV326_RS17155	COG3732	PTS system glucitol sorbitol-specific
HV326_RS17165	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS17170	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS17175	COG1349	DNA-binding transcription factor activity
HV326_RS17185	COG3604	Transcriptional regulator
HV326_RS17190	COG0426	domain, Protein
HV326_RS17190	COG1773	rubredoxin
HV326_RS17195	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV326_RS17200	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV326_RS17205	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV326_RS17210	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV326_RS17215	COG1609	Transcriptional regulator
HV326_RS17220	COG1263	PTS System
HV326_RS17220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV326_RS17225	COG2723	6-phospho-beta-galactosidase activity
HV326_RS17230	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV326_RS17240	COG3260	NADH ubiquinone oxidoreductase 20
HV326_RS17245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV326_RS17250	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV326_RS17250	COG3261	NADH dehydrogenase
HV326_RS17255	COG0650	Formate hydrogenlyase subunit 4
HV326_RS17260	COG0651	ATP synthesis coupled electron transport
HV326_RS17265	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV326_RS17275	COG0375	protein maturation
HV326_RS17280	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV326_RS17285	COG0298	carbon dioxide binding
HV326_RS17290	COG0409	Hydrogenase expression formation protein
HV326_RS17295	COG0309	Hydrogenase expression formation protein (HypE)
HV326_RS17310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV326_RS17315	COG1120	ATPase activity
HV326_RS17335	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HV326_RS17345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV326_RS17350	COG0163	prenyltransferase activity
HV326_RS17365	COG0477	Major facilitator Superfamily
HV326_RS17380	COG4942	peptidase
HV326_RS17380	COG1388	LysM domain
HV326_RS17395	COG0585	pseudouridine synthase activity
HV326_RS17400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HV326_RS17405	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HV326_RS17410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HV326_RS17420	COG0529	Catalyzes the synthesis of activated sulfate
HV326_RS17440	COG2234	aminopeptidase activity
HV326_RS17455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HV326_RS17460	COG0720	synthase
HV326_RS17470	COG1473	amidohydrolase
HV326_RS17480	COG0602	queuosine metabolic process
HV326_RS17485	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV326_RS17490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV326_RS17490	COG2190	(PTS) system
HV326_RS17490	COG1263	PTS System
HV326_RS17495	COG1737	Transcriptional regulator
HV326_RS17510	COG3956	TIGRFAM MazG family protein
HV326_RS17515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV326_RS17520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV326_RS17525	COG2205	protein histidine kinase activity
HV326_RS17525	COG3437	response regulator, receiver
HV326_RS17525	COG4999	Histidine kinase
HV326_RS17525	COG3850	Histidine kinase
HV326_RS17530	COG1929	Belongs to the glycerate kinase type-1 family
HV326_RS17535	COG4948	Mandelate Racemase Muconate Lactonizing
HV326_RS17540	COG4948	Mandelate Racemase Muconate Lactonizing
HV326_RS17545	COG2271	Major facilitator Superfamily
HV326_RS17550	COG0716	FMN binding
HV326_RS17555	COG0564	pseudouridine synthase activity
HV326_RS17560	COG3098	single-species biofilm formation
HV326_RS17575	COG1611	Belongs to the LOG family
HV326_RS17580	COG0814	amino acid
HV326_RS17585	COG1760	l-serine dehydratase
HV326_RS17595	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HV326_RS17600	COG2363	Small membrane protein
HV326_RS17605	COG0583	DNA-binding transcription factor activity
HV326_RS17615	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV326_RS17620	COG2166	iron-sulfur cluster assembly
HV326_RS17625	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV326_RS17630	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV326_RS17650	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV326_RS17655	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV326_RS17655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV326_RS17660	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV326_RS17665	COG1074	ATP-dependent DNA helicase activity
HV326_RS17675	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV326_RS17680	COG4967	type IV pilus modification protein PilV
HV326_RS17690	COG4795	General secretion pathway protein
HV326_RS17695	COG2165	general secretion pathway protein
HV326_RS17700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HV326_RS17705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HV326_RS17715	COG0494	nUDIX hydrolase
HV326_RS17720	COG3066	DNA modification
HV326_RS17730	COG0667	Aldo Keto reductase
HV326_RS17735	COG0477	Major facilitator Superfamily
HV326_RS17740	COG0204	Acyl-transferase
HV326_RS17740	COG0318	PFAM AMP-dependent synthetase and ligase
HV326_RS17745	COG1609	Transcriptional regulator
HV326_RS17755	COG2186	Transcriptional regulator
HV326_RS17760	COG2723	6-phospho-beta-galactosidase activity
HV326_RS17765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV326_RS17770	COG1609	Transcriptional regulator
HV326_RS17780	COG0583	DNA-binding transcription factor activity
HV326_RS17785	COG1794	racemase activity, acting on amino acids and derivatives
HV326_RS17795	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV326_RS17800	COG1175	transmembrane transport
HV326_RS17805	COG0395	ABC-type sugar transport system, permease component
HV326_RS17810	COG3842	ATPase activity
HV326_RS17820	COG2814	Major facilitator Superfamily
HV326_RS17825	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS17835	COG0823	Involved in the tonB-independent uptake of proteins
HV326_RS17840	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV326_RS17845	COG0183	Belongs to the thiolase family
HV326_RS17860	COG0814	amino acid
HV326_RS17865	COG2388	GCN5-related N-acetyl-transferase
HV326_RS17870	COG3592	Divergent 4Fe-4S mono-cluster
HV326_RS17875	COG3729	General stress protein
HV326_RS17880	COG3685	Protein conserved in bacteria
HV326_RS17885	COG3685	Protein conserved in bacteria
HV326_RS17890	COG3546	catalase activity
HV326_RS17895	COG1271	oxidase subunit
HV326_RS17900	COG1294	oxidase, subunit
HV326_RS17915	COG1546	Belongs to the CinA family
HV326_RS17930	COG3111	PFAM Bacterial OB fold (BOF) protein
HV326_RS17935	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS17940	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HV326_RS17960	COG2067	long-chain fatty acid transport protein
HV326_RS17965	COG1335	isochorismatase
HV326_RS18040	COG4942	peptidase
HV326_RS18045	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HV326_RS18050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HV326_RS18060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV326_RS18070	COG4974	Belongs to the 'phage' integrase family
HV326_RS18085	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV326_RS18090	COG0354	folic acid binding
HV326_RS18095	COG1272	protein, Hemolysin III
HV326_RS18100	COG1737	Transcriptional regulator
HV326_RS18105	COG2723	6-phospho-beta-galactosidase activity
HV326_RS18125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV326_RS18130	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS18135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HV326_RS18135	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HV326_RS18145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HV326_RS18150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV326_RS18155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV326_RS18160	COG0006	proline dipeptidase activity
HV326_RS18170	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HV326_RS18180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV326_RS18185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV326_RS18190	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HV326_RS18195	COG0583	DNA-binding transcription factor activity
HV326_RS18200	COG2968	Membrane
HV326_RS18205	COG1279	arginine transmembrane transporter activity
HV326_RS18210	COG0668	transmembrane transport
HV326_RS18215	COG0191	fructose-bisphosphate aldolase activity
HV326_RS18220	COG0126	phosphoglycerate kinase activity
HV326_RS18225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HV326_RS18230	COG1072	(Pantothenic acid kinase))
HV326_RS18240	COG1494	fructose-1,6-bisphosphatase
HV326_RS18245	COG1063	alcohol dehydrogenase
HV326_RS18250	COG2213	PTS system mannitol-specific
HV326_RS18255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS18260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV326_RS18265	COG0501	Belongs to the peptidase M48B family
HV326_RS18280	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HV326_RS18285	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS18290	COG2267	carboxylic ester hydrolase activity
HV326_RS18315	COG1414	Transcriptional regulator
HV326_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS18335	COG2146	nitrite reductase [NAD(P)H] activity
HV326_RS18345	COG0010	Belongs to the arginase family
HV326_RS18350	COG1166	arginine decarboxylase activity
HV326_RS18370	COG2814	Major facilitator Superfamily
HV326_RS18375	COG3091	SprT-like family
HV326_RS18380	COG2356	endonuclease I
HV326_RS18385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV326_RS18405	COG2805	Type II/IV secretion system protein
HV326_RS18410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV326_RS18415	COG0762	integral membrane protein
HV326_RS18420	COG1872	DUF167
HV326_RS18430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV326_RS18435	COG2852	Protein conserved in bacteria
HV326_RS18445	COG3171	Protein conserved in bacteria
HV326_RS18455	COG1194	a g-specific adenine glycosylase
HV326_RS18465	COG0741	lytic transglycosylase activity
HV326_RS18470	COG2211	Major facilitator Superfamily
HV326_RS18475	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HV326_RS18495	COG3052	prosthetic group binding
HV326_RS18505	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV326_RS18510	COG3493	citrate carrier protein
HV326_RS18525	COG1982	Orn Lys Arg decarboxylase major
HV326_RS18530	COG1811	Na channel or pump
HV326_RS18560	COG4974	Belongs to the 'phage' integrase family
HV326_RS18595	COG4735	regulation of single-species biofilm formation
HV326_RS18600	COG2378	regulation of single-species biofilm formation
HV326_RS18635	COG5002	protein histidine kinase activity
HV326_RS18640	COG2197	response regulator
HV326_RS18660	COG0457	Tetratricopeptide repeat
HV326_RS18665	COG0726	polysaccharide deacetylase
HV326_RS18665	COG1649	PFAM Uncharacterised BCR, COG1649
HV326_RS18670	COG1215	transferase activity, transferring glycosyl groups
HV326_RS18680	COG0754	glutathionylspermidine amidase activity
HV326_RS18685	COG0625	glutathione transferase activity
HV326_RS18690	COG1349	DNA-binding transcription factor activity
HV326_RS18700	COG0667	Aldo Keto reductase
HV326_RS18705	COG2862	Uncharacterized protein family, UPF0114
HV326_RS18725	COG0848	biopolymer transport protein
HV326_RS18735	COG0626	cystathionine gamma-synthase activity
HV326_RS18740	COG0586	Pfam SNARE associated Golgi protein
HV326_RS18745	COG2207	Transcriptional regulator
HV326_RS18750	COG1979	alcohol dehydrogenase
HV326_RS18795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV326_RS18805	COG1595	DNA-templated transcription, initiation
HV326_RS18810	COG3712	iron ion homeostasis
HV326_RS18815	COG4772	TonB-dependent receptor
HV326_RS18820	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HV326_RS18825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV326_RS18830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV326_RS18835	COG1120	ATPase activity
HV326_RS18840	COG3436	PFAM IS66 Orf2 family protein
HV326_RS18865	COG1609	Transcriptional regulator
HV326_RS18875	COG2223	nitrite transmembrane transporter activity
HV326_RS18920	COG1234	tRNA 3'-trailer cleavage
HV326_RS18930	COG0583	DNA-binding transcription factor activity
HV326_RS18935	COG1902	pentaerythritol trinitrate reductase activity
HV326_RS18940	COG0640	Transcriptional regulator
HV326_RS18995	COG3111	PFAM Bacterial OB fold (BOF) protein
HV326_RS19010	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV326_RS19015	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV326_RS19020	COG1652	LysM domain
HV326_RS19025	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV326_RS19030	COG2211	Major facilitator Superfamily
HV326_RS19045	COG0187	DNA topoisomerase II activity
HV326_RS19050	COG3150	esterase
HV326_RS19055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV326_RS19060	COG3151	Protein conserved in bacteria
HV326_RS19065	COG0494	nUDIX hydrolase
HV326_RS19080	COG0754	glutathionylspermidine amidase activity
HV326_RS19085	COG3384	dioxygenase
HV326_RS19095	COG3539	Fimbrial protein
HV326_RS19100	COG3188	usher protein
HV326_RS19105	COG3121	Chaperone
HV326_RS19110	COG3539	Fimbrial protein
HV326_RS19115	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HV326_RS19125	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HV326_RS19125	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HV326_RS19135	COG3025	triphosphatase activity
HV326_RS19140	COG4991	sh3 domain protein
HV326_RS19145	COG0617	tRNA 3'-terminal CCA addition
HV326_RS19155	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV326_RS19165	COG0477	Major facilitator Superfamily
HV326_RS19170	COG0829	nickel cation binding
HV326_RS19175	COG0831	urea catabolic process
HV326_RS19180	COG0832	Belongs to the urease beta subunit family
HV326_RS19185	COG0804	urea catabolic process
HV326_RS19190	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV326_RS19200	COG0830	nickel cation binding
HV326_RS19205	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV326_RS19215	COG2197	response regulator
HV326_RS19225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV326_RS19230	COG0358	DNA primase activity
HV326_RS19240	COG3663	DNA glycosylase
HV326_RS19270	COG2375	cellular response to nickel ion
HV326_RS19275	COG1695	Transcriptional regulator
HV326_RS19280	COG0840	transmembrane signaling receptor activity
HV326_RS19285	COG0840	transmembrane signaling receptor activity
HV326_RS19290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV326_RS19305	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV326_RS19310	COG1830	Aldolase
HV326_RS19315	COG1879	ABC-type sugar transport system periplasmic component
HV326_RS19320	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV326_RS19325	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV326_RS19330	COG1129	ABC transporter
HV326_RS19335	COG2390	Transcriptional regulator
HV326_RS19340	COG1070	Carbohydrate kinase
HV326_RS19345	COG1902	pentaerythritol trinitrate reductase activity
HV326_RS19345	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV326_RS19355	COG1451	nucleotide metabolic process
HV326_RS19360	COG0673	inositol 2-dehydrogenase activity
HV326_RS19365	COG0861	Integral membrane protein TerC family
HV326_RS19375	COG2721	sulfolactate sulfo-lyase activity
HV326_RS19385	COG2271	Major facilitator Superfamily
HV326_RS19390	COG2186	Transcriptional regulator
HV326_RS19395	COG0586	Pfam SNARE associated Golgi protein
HV326_RS19405	COG1422	Protein of unknown function (DUF1090)
HV326_RS19410	COG4575	ribosome binding
HV326_RS19415	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV326_RS19425	COG2259	Doxx family
HV326_RS19430	COG0435	Glutathione S-transferase
HV326_RS19435	COG3152	Membrane
HV326_RS19440	COG0583	DNA-binding transcription factor activity
HV326_RS19445	COG1741	Belongs to the pirin family
HV326_RS19455	COG0814	amino acid
HV326_RS19460	COG1882	Formate acetyltransferase
HV326_RS19465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HV326_RS19470	COG0814	amino acid
HV326_RS19475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV326_RS19480	COG0583	DNA-binding transcription factor activity
HV326_RS19490	COG1929	Belongs to the glycerate kinase type-1 family
HV326_RS19495	COG2084	Dehydrogenase
HV326_RS19505	COG2721	sulfolactate sulfo-lyase activity
HV326_RS19510	COG1349	DNA-binding transcription factor activity
HV326_RS19520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV326_RS19530	COG3716	PTS system mannose fructose sorbose family IID component
HV326_RS19535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS19540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV326_RS19545	COG2222	sugar isomerase
HV326_RS19550	COG0191	fructose-bisphosphate aldolase activity
HV326_RS19555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV326_RS19555	COG1263	PTS System
HV326_RS19570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV326_RS19575	COG3107	peptidoglycan biosynthetic process
HV326_RS19580	COG0792	nuclease activity
HV326_RS19585	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HV326_RS19590	COG2823	Periplasmic or secreted lipoprotein
HV326_RS19595	COG0701	Predicted permease
HV326_RS19600	COG0702	epimerase
HV326_RS19605	COG0693	protein deglycase activity
HV326_RS19610	COG3787	Belongs to the UPF0306 family
HV326_RS19615	COG2827	Endonuclease containing a URI domain
HV326_RS19620	COG3153	acetyltransferase
HV326_RS19625	COG3154	lipid carrier protein
HV326_RS19630	COG0826	peptidase U32
HV326_RS19635	COG0826	peptidase U32
HV326_RS19640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV326_RS19645	COG0814	amino acid
HV326_RS19650	COG0513	Belongs to the DEAD box helicase family
HV326_RS19670	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HV326_RS19675	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HV326_RS19680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV326_RS19685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HV326_RS19705	COG0137	argininosuccinate synthase activity
HV326_RS19715	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV326_RS19720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV326_RS19725	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV326_RS19730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV326_RS19735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HV326_RS19740	COG1534	Rna-binding protein
HV326_RS19750	COG2027	D-alanyl-D-alanine carboxypeptidase
HV326_RS19755	COG0745	RESPONSE REGULATOR receiver
HV326_RS19760	COG0642	Histidine kinase
HV326_RS19765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HV326_RS19770	COG0697	spore germination
HV326_RS19780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV326_RS19785	COG0142	geranyltranstransferase activity
HV326_RS19790	COG3423	Transcriptional regulator
HV326_RS19795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HV326_RS19800	COG5007	Belongs to the BolA IbaG family
HV326_RS19805	COG3113	response to antibiotic
HV326_RS19810	COG2854	intermembrane phospholipid transfer
HV326_RS19815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV326_RS19820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV326_RS19825	COG1127	ABC transporter
HV326_RS19830	COG0530	calcium, potassium:sodium antiporter activity
HV326_RS19840	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV326_RS19845	COG3117	lipopolysaccharide transmembrane transporter activity
HV326_RS19850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV326_RS19855	COG1137	ATPase activity
HV326_RS19860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HV326_RS19880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS19890	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV326_RS19895	COG2198	Histidine kinase
HV326_RS19895	COG5002	protein histidine kinase activity
HV326_RS19895	COG0784	Response regulator, receiver
HV326_RS19900	COG0795	lipopolysaccharide-transporting ATPase activity
HV326_RS19905	COG0795	lipopolysaccharide-transporting ATPase activity
HV326_RS19910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HV326_RS19915	COG2927	DNA polymerase III (CHI subunit)
HV326_RS19930	COG1064	alcohol dehydrogenase
HV326_RS19940	COG0433	COG0433 Predicted ATPase
HV326_RS19945	COG1242	4 iron, 4 sulfur cluster binding
HV326_RS19950	COG0069	glutamate synthase activity
HV326_RS19950	COG0070	glutamate synthase
HV326_RS19950	COG0067	glutamate synthase
HV326_RS19955	COG0493	'glutamate synthase
HV326_RS19960	COG3539	Fimbrial protein
HV326_RS19970	COG3188	usher protein
HV326_RS19975	COG3121	Chaperone
HV326_RS19980	COG3539	Fimbrial protein
HV326_RS19985	COG2969	positive regulation of protein catabolic process
HV326_RS19990	COG0625	glutathione transferase activity
HV326_RS19995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HV326_RS20005	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV326_RS20010	COG3105	Protein conserved in bacteria
HV326_RS20015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV326_RS20020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV326_RS20030	COG1438	arginine binding
HV326_RS20040	COG2732	(Barnase) inhibitor
HV326_RS20045	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS20050	COG1289	transmembrane transporter activity
HV326_RS20065	COG0583	DNA-binding transcription factor activity
HV326_RS20070	COG3477	response to acidic pH
HV326_RS20075	COG0312	modulator of DNA gyrase
HV326_RS20080	COG3164	Protein of unknown function
HV326_RS20085	COG1530	ribonuclease E activity
HV326_RS20095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV326_RS20100	COG1792	Involved in formation and maintenance of cell shape
HV326_RS20105	COG1077	Cell shape determining protein MreB Mrl
HV326_RS20110	COG2199	diguanylate cyclase activity
HV326_RS20110	COG2200	EAL domain
HV326_RS20115	COG0604	alcohol dehydrogenase
HV326_RS20125	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HV326_RS20130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HV326_RS20135	COG0511	ligase activity, forming carbon-carbon bonds
HV326_RS20140	COG0439	Biotin carboxylase
HV326_RS20145	COG3924	membrane
HV326_RS20150	COG4145	pantothenate transmembrane transporter activity
HV326_RS20190	COG1802	Transcriptional regulator
HV326_RS20190	COG4626	Terminase
HV326_RS20270	COG3311	Transcriptional regulator
HV326_RS20280	COG3039	Transposase
HV326_RS20300	COG1309	transcriptional regulator
HV326_RS20305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV326_RS20310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV326_RS20350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV326_RS20360	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HV326_RS20365	COG0009	L-threonylcarbamoyladenylate synthase
HV326_RS20370	COG0551	DNA topoisomerase type I activity
HV326_RS20375	COG2922	Belongs to the Smg family
HV326_RS20380	COG0758	DNA mediated transformation
HV326_RS20385	COG0242	peptide deformylase activity
HV326_RS20390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HV326_RS20395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HV326_RS20395	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HV326_RS20405	COG1970	mechanosensitive ion channel activity
HV326_RS20410	COG3036	rescue of stalled ribosome
HV326_RS20415	COG0789	Transcriptional regulator
HV326_RS20430	COG0202	RNA polymerase activity
HV326_RS20440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV326_RS20455	COG0201	protein transport
HV326_RS20465	COG1841	ribosomal large subunit assembly
HV326_RS20480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HV326_RS20485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HV326_RS20515	COG0255	Belongs to the universal ribosomal protein uL29 family
HV326_RS20520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HV326_RS20560	COG0051	transcription antitermination factor activity, RNA binding
HV326_RS20600	COG2168	tRNA wobble position uridine thiolation
HV326_RS20605	COG2923	Belongs to the DsrF TusC family
HV326_RS20610	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV326_RS20615	COG2964	Protein conserved in bacteria
HV326_RS20620	COG0545	Peptidyl-prolyl cis-trans isomerase
HV326_RS20630	COG1047	Peptidyl-prolyl cis-trans
HV326_RS20635	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV326_RS20640	COG0475	glutathione-regulated potassium exporter activity
HV326_RS20640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV326_RS20645	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV326_RS20650	COG0488	(ABC) transporter
HV326_RS20660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HV326_RS20670	COG0679	Auxin Efflux Carrier
HV326_RS20700	COG0429	hydrolase of the alpha beta-hydrolase fold
HV326_RS20705	COG3089	Belongs to the UPF0270 family
HV326_RS20710	COG3954	Phosphoribulokinase
HV326_RS20715	COG1765	OsmC-like protein
HV326_RS20725	COG1289	transmembrane transporter activity
HV326_RS20730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV326_RS20735	COG0512	Glutamine amidotransferase of anthranilate synthase
HV326_RS20740	COG2184	nucleotidyltransferase activity
HV326_RS20750	COG0738	Major facilitator superfamily
HV326_RS20755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV326_RS20765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV326_RS20765	COG1648	precorrin-2 dehydrogenase activity
HV326_RS20775	COG0180	Tryptophanyl-tRNA synthetase
HV326_RS20785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV326_RS20790	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV326_RS20795	COG3266	domain, Protein
HV326_RS20800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HV326_RS20805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HV326_RS20810	COG4796	Type ii and iii secretion system protein
HV326_RS20830	COG4972	Pilus assembly protein
HV326_RS20835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV326_RS20840	COG0494	nUDIX hydrolase
HV326_RS20850	COG1011	Hydrolase
HV326_RS20855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV326_RS20860	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HV326_RS20865	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV326_RS20870	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HV326_RS20880	COG0745	RESPONSE REGULATOR receiver
HV326_RS20885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV326_RS20890	COG2183	response to ionizing radiation
HV326_RS20895	COG1918	ferrous iron import across plasma membrane
HV326_RS20915	COG1040	competence protein
HV326_RS20925	COG2610	gluconate transmembrane transporter activity
HV326_RS20930	COG1640	4-alpha-glucanotransferase
HV326_RS20935	COG0058	SHG alpha-glucan phosphorylase activity
HV326_RS20940	COG2909	trisaccharide binding
HV326_RS20945	COG1349	DNA-binding transcription factor activity
HV326_RS20950	COG0705	Rhomboid family
HV326_RS20955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV326_RS20960	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV326_RS20965	COG0058	SHG alpha-glucan phosphorylase activity
HV326_RS20970	COG0297	glycogen (starch) synthase activity
HV326_RS20975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HV326_RS20980	COG1523	belongs to the glycosyl hydrolase 13 family
HV326_RS20985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HV326_RS20990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV326_RS20995	COG2095	MarC family integral membrane protein
HV326_RS21005	COG2610	gluconate transmembrane transporter activity
HV326_RS21010	COG3265	gluconokinase activity
HV326_RS21015	COG1609	Transcriptional regulator
HV326_RS21020	COG1741	Belongs to the pirin family
HV326_RS21025	COG0673	inositol 2-dehydrogenase activity
HV326_RS21030	COG1247	-acetyltransferase
HV326_RS21035	COG0405	Gamma-glutamyltransferase
HV326_RS21045	COG0584	glycerophosphoryl diester phosphodiesterase
HV326_RS21075	COG0411	ABC transporter
HV326_RS21080	COG4177	L-phenylalanine transmembrane transporter activity
HV326_RS21090	COG0683	leucine binding
HV326_RS21095	COG0456	acetyltransferase
HV326_RS21100	COG0683	leucine binding
HV326_RS21105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV326_RS21110	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HV326_RS21115	COG2177	Part of the ABC transporter FtsEX involved in
HV326_RS21120	COG2884	Cell division ATP-binding protein ftsE
HV326_RS21125	COG0552	protein localization to endoplasmic reticulum
HV326_RS21130	COG0742	ribosomal rna small subunit methyltransferase
HV326_RS21135	COG3776	membrane
HV326_RS21145	COG3714	YhhN family
HV326_RS21150	COG2217	Heavy metal translocating P-type atpase
HV326_RS21165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV326_RS21170	COG0425	Belongs to the sulfur carrier protein TusA family
HV326_RS21175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV326_RS21185	COG0628	permease
HV326_RS21205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV326_RS21225	COG1216	Glycosyl transferase, family 2
HV326_RS21250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV326_RS21260	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS21265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV326_RS21275	COG3479	Phenolic acid decarboxylase
HV326_RS21280	COG0583	DNA-binding transcription factor activity
HV326_RS21285	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS21305	COG1414	Transcriptional regulator
HV326_RS21310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HV326_RS21315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV326_RS21325	COG2205	protein histidine kinase activity
HV326_RS21330	COG0745	RESPONSE REGULATOR receiver
HV326_RS21335	COG1276	copper resistance
HV326_RS21340	COG2372	response to copper ion
HV326_RS21345	COG3667	copper resistance
HV326_RS21350	COG2132	Multicopper oxidase
HV326_RS21360	COG0739	heme binding
HV326_RS21390	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV326_RS21455	COG2081	HI0933 family
HV326_RS21460	COG0306	phosphate transporter
HV326_RS21470	COG0589	response to stress
HV326_RS21475	COG0742	ribosomal rna small subunit methyltransferase
HV326_RS21480	COG0339	signal peptide processing
HV326_RS21485	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV326_RS21490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV326_RS21510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV326_RS21520	COG2197	response regulator
HV326_RS21525	COG1028	Short-chain dehydrogenase reductase Sdr
HV326_RS21530	COG0583	DNA-binding transcription factor activity
HV326_RS21535	COG1295	ribonuclease BN
HV326_RS21540	COG0477	Major facilitator Superfamily
HV326_RS21545	COG2982	Protein involved in outer membrane biogenesis
HV326_RS21550	COG2200	EAL domain
HV326_RS21560	COG0612	Peptidase, M16
HV326_RS21565	COG1301	dicarboxylic acid transport
HV326_RS21570	COG2200	EAL domain
HV326_RS21570	COG2199	diguanylate cyclase activity
HV326_RS21575	COG0457	Tetratricopeptide repeat
HV326_RS21575	COG3118	belongs to the thioredoxin family
HV326_RS21580	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HV326_RS21585	COG1215	transferase activity, transferring glycosyl groups
HV326_RS21615	COG2194	sulfuric ester hydrolase activity
HV326_RS21625	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV326_RS21655	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HV326_RS21665	COG1739	Uncharacterized protein family UPF0029
HV326_RS21670	COG0006	proline dipeptidase activity
HV326_RS21675	COG1024	Enoyl-CoA hydratase
HV326_RS21675	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV326_RS21680	COG0183	Belongs to the thiolase family
HV326_RS21685	COG0751	glycine-tRNA ligase activity
HV326_RS21690	COG0752	glycyl-tRNA synthetase alpha subunit
HV326_RS21700	COG3274	enterobacterial common antigen metabolic process
HV326_RS21705	COG1070	Carbohydrate kinase
HV326_RS21710	COG2115	Belongs to the xylose isomerase family
HV326_RS21715	COG3039	Transposase
HV326_RS21720	COG4213	ABC transporter substrate-binding protein
HV326_RS21730	COG4214	carbohydrate transport
HV326_RS21735	COG1609	Transcriptional regulator
HV326_RS21735	COG2207	Transcriptional regulator
HV326_RS21740	COG2992	FlgJ-related protein
HV326_RS21745	COG0366	Alpha amylase catalytic
HV326_RS21750	COG3977	Valine--pyruvate aminotransferase
HV326_RS21755	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV326_RS21760	COG1414	Transcriptional regulator
HV326_RS21770	COG2731	YhcH YjgK YiaL family protein
HV326_RS21780	COG2271	Major facilitator Superfamily
HV326_RS21785	COG1070	Carbohydrate kinase
HV326_RS21790	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV326_RS21795	COG3623	hexulose-6-phosphate isomerase
HV326_RS21800	COG0235	Class ii aldolase
HV326_RS21810	COG2211	Major facilitator Superfamily
HV326_RS21820	COG1012	belongs to the aldehyde dehydrogenase family
HV326_RS21825	COG1940	carbohydrate kinase activity
HV326_RS21830	COG3276	selenocysteine insertion sequence binding
HV326_RS21840	COG0625	glutathione transferase activity
HV326_RS21845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV326_RS21845	COG2213	PTS system mannitol-specific
HV326_RS21855	COG3722	fumarate hydratase activity
HV326_RS21875	COG3121	Chaperone
HV326_RS21880	COG3539	Fimbrial protein
HV326_RS21890	COG2186	Transcriptional regulator
HV326_RS21900	COG2271	Major facilitator Superfamily
HV326_RS21905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV326_RS21915	COG0583	DNA-binding transcription factor activity
HV326_RS21920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV326_RS21930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV326_RS21935	COG3978	acetolactate synthase activity
HV326_RS21955	COG3085	chromosome segregation
HV326_RS22005	COG4206	TonB-dependent receptor
HV326_RS22010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV326_RS22030	COG0583	DNA-binding transcription factor activity
HV326_RS22035	COG0165	Argininosuccinate lyase
HV326_RS22045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HV326_RS22050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HV326_RS22055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HV326_RS22060	COG0371	Dehydrogenase
HV326_RS22065	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HV326_RS22075	COG0527	aspartate kinase activity
HV326_RS22075	COG0460	homoserine dehydrogenase
HV326_RS22080	COG0626	cystathionine gamma-synthase activity
HV326_RS22095	COG0254	rRNA binding
HV326_RS22100	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV326_RS22105	COG1609	Transcriptional regulator
HV326_RS22110	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV326_RS22125	COG1575	Belongs to the MenA family. Type 1 subfamily
HV326_RS22130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HV326_RS22135	COG3074	FtsZ-dependent cytokinesis
HV326_RS22140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV326_RS22150	COG1494	fructose-1,6-bisphosphatase
HV326_RS22160	COG3152	Membrane
HV326_RS22170	COG0149	triose-phosphate isomerase activity
HV326_RS22180	COG2134	cdp-diacylglycerol pyrophosphatase
HV326_RS22190	COG0205	6-phosphofructokinase activity
HV326_RS22200	COG3678	ATP-independent chaperone mediated protein folding
HV326_RS22205	COG0745	RESPONSE REGULATOR receiver
HV326_RS22210	COG2205	protein histidine kinase activity
HV326_RS22215	COG2258	MOSC domain
HV326_RS22230	COG4977	sequence-specific DNA binding
HV326_RS22230	COG1917	Cupin 2, conserved barrel domain protein
HV326_RS22235	COG4977	sequence-specific DNA binding
HV326_RS22240	COG1070	Carbohydrate kinase
HV326_RS22245	COG4806	L-rhamnose isomerase
HV326_RS22250	COG0235	Class ii aldolase
HV326_RS22260	COG1129	ABC transporter
HV326_RS22265	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV326_RS22275	COG1454	alcohol dehydrogenase
HV326_RS22280	COG3254	rhamnose metabolic process
HV326_RS22285	COG2211	Major facilitator Superfamily
HV326_RS22305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV326_RS22320	COG3188	usher protein
HV326_RS22325	COG3121	Chaperone
HV326_RS22350	COG0437	4 iron, 4 sulfur cluster binding
HV326_RS22355	COG2864	formate dehydrogenase
HV326_RS22360	COG3058	Necessary for formate dehydrogenase activity
HV326_RS22370	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV326_RS22380	COG0456	acetyltransferase
HV326_RS22395	COG1011	Hydrolase
HV326_RS22400	COG1349	DNA-binding transcription factor activity
HV326_RS22405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV326_RS22415	COG3684	Belongs to the aldolase LacD family
HV326_RS22425	COG1501	Belongs to the glycosyl hydrolase 31 family
HV326_RS22445	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HV326_RS22460	COG3852	Histidine kinase
HV326_RS22475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV326_RS22480	COG3078	GTPase activator activity
HV326_RS22505	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HV326_RS22510	COG3084	Protein conserved in bacteria
HV326_RS22515	COG0746	molybdenum cofactor guanylyltransferase activity
HV326_RS22520	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV326_RS22545	COG2186	Transcriptional regulator
HV326_RS22550	COG0477	Major facilitator Superfamily
HV326_RS22555	COG1609	Transcriptional regulator
HV326_RS22560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV326_RS22570	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV326_RS22575	COG1129	ABC transporter
HV326_RS22580	COG1869	D-ribose catabolic process
HV326_RS22585	COG3158	transport of potassium into the cell
HV326_RS22595	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HV326_RS22600	COG2502	aspartate--ammonia ligase
HV326_RS22605	COG1522	sequence-specific DNA binding
HV326_RS22610	COG0716	FMN binding
HV326_RS22615	COG0445	tRNA wobble uridine modification
HV326_RS22620	COG0357	Ribosomal RNA small subunit methyltransferase G
HV326_RS22625	COG3312	ion transport
HV326_RS22630	COG0356	it plays a direct role in the translocation of protons across the membrane
HV326_RS22640	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HV326_RS22645	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HV326_RS22660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV326_RS22665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV326_RS22670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV326_RS22680	COG3539	Fimbrial protein
HV326_RS22685	COG3121	Chaperone
HV326_RS22695	COG3539	Fimbrial protein
HV326_RS22700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV326_RS22705	COG0573	inorganic phosphate transmembrane transporter activity
HV326_RS22710	COG0581	inorganic phosphate transmembrane transporter activity
HV326_RS22715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HV326_RS22720	COG0704	Plays a role in the regulation of phosphate uptake
HV326_RS22725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV326_RS22730	COG2252	PERMEase
HV326_RS22735	COG0431	NADPH-dependent FMN reductase
HV326_RS22740	COG2091	lysine biosynthetic process via aminoadipic acid
HV326_RS22755	COG0456	acetyltransferase
HV326_RS22765	COG0706	membrane insertase activity
HV326_RS22870	COG0071	Belongs to the small heat shock protein (HSP20) family
HV326_RS22875	COG0542	response to heat
HV326_RS22925	COG0501	Belongs to the peptidase M48B family
HV326_RS22930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV326_RS22950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV326_RS22955	COG1127	ABC transporter
HV326_RS22975	COG2951	lytic endotransglycosylase activity
HV326_RS23035	COG3039	Transposase
HV326_RS23055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HV326_RS23060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HV326_RS23065	COG2986	histidine ammonia-lyase
HV326_RS23080	COG2358	TRAP transporter, solute receptor (TAXI family
HV326_RS23090	COG0402	S-adenosylhomocysteine deaminase activity
HV326_RS23100	COG1228	amidohydrolase
HV326_RS23155	COG3344	reverse transcriptase