locus-tag	class	description
IE977_RS00010	COG0592	DNA-directed DNA polymerase activity
IE977_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IE977_RS00025	COG0583	DNA-binding transcription factor activity
IE977_RS00030	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS00030	COG0604	alcohol dehydrogenase
IE977_RS00030	COG3321	synthase
IE977_RS00035	COG0561	phosphatase activity
IE977_RS00040	COG2186	Transcriptional regulator
IE977_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
IE977_RS00050	COG0800	Aldolase
IE977_RS00055	COG4948	Mandelate Racemase Muconate Lactonizing
IE977_RS00060	COG2271	Major facilitator Superfamily
IE977_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
IE977_RS00070	COG5645	(Lipo)protein
IE977_RS00080	COG0071	Belongs to the small heat shock protein (HSP20) family
IE977_RS00085	COG2985	domain, Protein
IE977_RS00090	COG2188	Transcriptional regulator
IE977_RS00105	COG2149	membrane
IE977_RS00120	COG2610	gluconate transmembrane transporter activity
IE977_RS00125	COG0583	DNA-binding transcription factor activity
IE977_RS00135	COG2814	Major facilitator Superfamily
IE977_RS00160	COG0028	Belongs to the TPP enzyme family
IE977_RS00165	COG0440	acetolactate synthase activity
IE977_RS00170	COG2197	response regulator
IE977_RS00190	COG0596	Alpha beta hydrolase
IE977_RS00195	COG0583	DNA-binding transcription factor activity
IE977_RS00215	COG0697	spore germination
IE977_RS00220	COG4580	involved in the transport of maltose and maltodextrins
IE977_RS00225	COG1447	Phosphotransferase system cellobiose-specific component IIA
IE977_RS00230	COG2723	6-phospho-beta-galactosidase activity
IE977_RS00235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE977_RS00235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE977_RS00245	COG1609	Transcriptional regulator
IE977_RS00255	COG2814	Major facilitator Superfamily
IE977_RS00265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE977_RS00270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE977_RS00280	COG0454	-acetyltransferase
IE977_RS00285	COG1309	transcriptional regulator
IE977_RS00295	COG1464	Belongs to the NlpA lipoprotein family
IE977_RS00320	COG3188	usher protein
IE977_RS00325	COG3121	Chaperone
IE977_RS00355	COG3188	usher protein
IE977_RS00380	COG2274	protein secretion by the type I secretion system
IE977_RS00395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IE977_RS00410	COG3272	Protein of unknown function (DUF1722)
IE977_RS00415	COG2351	hydroxyisourate hydrolase activity
IE977_RS00445	COG3121	Chaperone
IE977_RS00475	COG0519	Catalyzes the synthesis of GMP from XMP
IE977_RS00520	COG2211	Major facilitator Superfamily
IE977_RS00525	COG1501	Belongs to the glycosyl hydrolase 31 family
IE977_RS00530	COG2982	Protein involved in outer membrane biogenesis
IE977_RS00535	COG2233	PERMEase
IE977_RS00540	COG0786	glutamate:sodium symporter activity
IE977_RS00545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IE977_RS00550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IE977_RS00555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IE977_RS00570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IE977_RS00590	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IE977_RS00595	COG1596	polysaccharide export
IE977_RS00600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IE977_RS00605	COG0489	protein tyrosine kinase activity
IE977_RS00605	COG3206	protein involved in exopolysaccharide biosynthesis
IE977_RS00610	COG2860	membrane
IE977_RS00615	COG1561	YicC-like family, N-terminal region
IE977_RS00625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IE977_RS00640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IE977_RS00645	COG2003	Belongs to the UPF0758 family
IE977_RS00650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IE977_RS00655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IE977_RS00660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IE977_RS00665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IE977_RS00675	COG1519	Transferase
IE977_RS00680	COG1216	Glycosyl transferase, family 2
IE977_RS00685	COG0438	transferase activity, transferring glycosyl groups
IE977_RS00695	COG0859	PFAM glycosyl transferase family 9
IE977_RS00720	COG0859	PFAM glycosyl transferase family 9
IE977_RS00725	COG0859	PFAM glycosyl transferase family 9
IE977_RS00740	COG1063	alcohol dehydrogenase
IE977_RS00750	COG0438	transferase activity, transferring glycosyl groups
IE977_RS00755	COG0463	Glycosyl transferase, family 2
IE977_RS00760	COG2861	carbohydrate metabolic process
IE977_RS00765	COG4942	peptidase
IE977_RS00770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IE977_RS00775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IE977_RS00780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IE977_RS00785	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IE977_RS00790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IE977_RS00800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IE977_RS00810	COG0248	Ppx GppA phosphatase
IE977_RS00820	COG3118	belongs to the thioredoxin family
IE977_RS00825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IE977_RS00830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IE977_RS00840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IE977_RS00845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IE977_RS00850	COG0456	acetyltransferase
IE977_RS00855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IE977_RS00860	COG2244	polysaccharide biosynthetic process
IE977_RS00875	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IE977_RS00905	COG3071	HemY protein
IE977_RS00910	COG2959	enzyme of heme biosynthesis
IE977_RS00920	COG0181	hydroxymethylbilane synthase activity
IE977_RS00935	COG5567	small periplasmic lipoprotein
IE977_RS00955	COG1011	Hydrolase
IE977_RS00960	COG0210	DNA helicase
IE977_RS00980	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
IE977_RS00990	COG1280	lysine exporter protein (LysE YggA)
IE977_RS00995	COG1280	lysine exporter protein (LysE YggA)
IE977_RS01000	COG2267	carboxylic ester hydrolase activity
IE977_RS01005	COG0561	phosphatase activity
IE977_RS01010	COG0697	spore germination
IE977_RS01015	COG0583	DNA-binding transcription factor activity
IE977_RS01025	COG0412	Dienelactone hydrolase
IE977_RS01035	COG1322	Protein conserved in bacteria
IE977_RS01040	COG2226	methyltransferase
IE977_RS01045	COG3165	ubiquinone biosynthetic process from chorismate
IE977_RS01050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IE977_RS01065	COG0805	protein transport
IE977_RS01070	COG0084	hydrolase, TatD family'
IE977_RS01080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IE977_RS01090	COG0488	(ABC) transporter
IE977_RS01095	COG2944	sequence-specific DNA binding
IE977_RS01105	COG1278	Cold shock
IE977_RS01110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IE977_RS01120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE977_RS01130	COG1609	Transcriptional regulator
IE977_RS01135	COG2885	chlorophyll binding
IE977_RS01140	COG0243	molybdopterin cofactor binding
IE977_RS01145	COG0456	acetyltransferase
IE977_RS01150	COG2818	Glycosylase
IE977_RS01155	COG5571	outer membrane autotransporter
IE977_RS01160	COG2223	nitrite transmembrane transporter activity
IE977_RS01175	COG0747	negative chemotaxis
IE977_RS01180	COG0601	transmembrane transport
IE977_RS01185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE977_RS01190	COG0444	Belongs to the ABC transporter superfamily
IE977_RS01195	COG4608	Belongs to the ABC transporter superfamily
IE977_RS01200	COG1072	(Pantothenic acid kinase))
IE977_RS01235	COG0250	Participates in transcription elongation, termination and antitermination
IE977_RS01280	COG3706	GGDEF domain
IE977_RS01290	COG2022	thiamine diphosphate biosynthetic process
IE977_RS01295	COG2104	thiamine diphosphate biosynthetic process
IE977_RS01300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IE977_RS01315	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
IE977_RS01325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IE977_RS01330	COG1515	deoxyribonuclease V activity
IE977_RS01335	COG3068	Protein conserved in bacteria
IE977_RS01350	COG0151	Belongs to the GarS family
IE977_RS01385	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IE977_RS01395	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IE977_RS01415	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IE977_RS01420	COG3657	addiction module killer protein
IE977_RS01425	COG1187	pseudouridine synthase activity
IE977_RS01440	COG0527	aspartate kinase activity
IE977_RS01465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IE977_RS01470	COG3223	Belongs to the PsiE family
IE977_RS01495	COG4580	involved in the transport of maltose and maltodextrins
IE977_RS01505	COG3161	chorismate lyase activity
IE977_RS01515	COG2937	Belongs to the GPAT DAPAT family
IE977_RS01520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IE977_RS01525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IE977_RS01530	COG0534	Mate efflux family protein
IE977_RS01535	COG3237	CsbD-like
IE977_RS01540	COG0735	belongs to the Fur family
IE977_RS01555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IE977_RS01565	COG0604	alcohol dehydrogenase
IE977_RS01570	COG0305	Participates in initiation and elongation during chromosome replication
IE977_RS01580	COG1448	Aminotransferase
IE977_RS01585	COG3700	Belongs to the class B bacterial acid phosphatase family
IE977_RS01595	COG2315	Protein conserved in bacteria
IE977_RS01605	COG0629	single-stranded DNA binding
IE977_RS01615	COG2199	diguanylate cyclase activity
IE977_RS01620	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IE977_RS01630	COG0789	Transcriptional regulator
IE977_RS01635	COG0625	glutathione transferase activity
IE977_RS01640	COG2252	PERMEase
IE977_RS01645	COG0025	NhaP-type Na H and K H
IE977_RS01650	COG0583	DNA-binding transcription factor activity
IE977_RS01660	COG1346	cytolysis
IE977_RS01665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IE977_RS01670	COG3162	membrane
IE977_RS01680	COG1301	dicarboxylic acid transport
IE977_RS01685	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IE977_RS01710	COG0191	fructose-bisphosphate aldolase activity
IE977_RS01725	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS01730	COG1129	ABC transporter
IE977_RS01735	COG4191	Histidine kinase
IE977_RS01735	COG0784	Response regulator, receiver
IE977_RS01740	COG1940	carbohydrate kinase activity
IE977_RS01745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IE977_RS01750	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS01755	COG1129	ABC transporter
IE977_RS01760	COG1879	ABC-type sugar transport system periplasmic component
IE977_RS01765	COG1737	Transcriptional regulator
IE977_RS01770	COG0698	ribose 5-phosphate isomerase
IE977_RS01780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IE977_RS01785	COG0456	acetyltransferase
IE977_RS01790	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IE977_RS01795	COG3454	Phosphonate metabolism
IE977_RS01800	COG4778	phosphonate C-P lyase system protein PhnL
IE977_RS01805	COG4107	phosphonate C-P lyase system protein PhnK
IE977_RS01810	COG3627	carbon phosphorus lyase activity
IE977_RS01815	COG3626	phosphonate metabolism
IE977_RS01820	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IE977_RS01825	COG3624	Phosphonate C-P lyase system protein PhnG
IE977_RS01830	COG2188	Transcriptional regulator
IE977_RS01835	COG3639	organic phosphonate transmembrane transporter activity
IE977_RS01840	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IE977_RS01850	COG2764	glyoxalase bleomycin resistance protein dioxygenase
IE977_RS01855	COG2824	Alkylphosphonate utilization operon protein PhnA
IE977_RS01860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IE977_RS01880	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IE977_RS01905	COG3647	Membrane
IE977_RS01910	COG2801	Transposase and inactivated derivatives
IE977_RS01925	COG3279	Response regulator of the LytR AlgR family
IE977_RS01930	COG3039	Transposase
IE977_RS01940	COG0366	Alpha amylase catalytic
IE977_RS01945	COG2190	(PTS) system
IE977_RS01945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS01945	COG1263	PTS System
IE977_RS01995	COG2378	regulation of single-species biofilm formation
IE977_RS02000	COG4735	regulation of single-species biofilm formation
IE977_RS02035	COG4974	Belongs to the 'phage' integrase family
IE977_RS02075	COG1309	transcriptional regulator
IE977_RS02090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IE977_RS02095	COG1027	Aspartate ammonia-lyase
IE977_RS02100	COG3030	protein affecting phage T7 exclusion by the F plasmid
IE977_RS02105	COG0531	amino acid
IE977_RS02115	COG0459	protein refolding
IE977_RS02120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IE977_RS02125	COG0700	Nucleoside recognition
IE977_RS02130	COG3366	ferrous iron transmembrane transporter activity
IE977_RS02155	COG5510	response to toxic substance
IE977_RS02180	COG0583	DNA-binding transcription factor activity
IE977_RS02190	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
IE977_RS02195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IE977_RS02200	COG1053	succinate dehydrogenase
IE977_RS02205	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IE977_RS02215	COG1511	domain protein
IE977_RS02215	COG3264	Mechanosensitive ion channel
IE977_RS02250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IE977_RS02255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IE977_RS02255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IE977_RS02260	COG0802	atpase or kinase
IE977_RS02270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IE977_RS02275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IE977_RS02280	COG1923	regulation of RNA biosynthetic process
IE977_RS02285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IE977_RS02290	COG0330	HflC and HflK could
IE977_RS02295	COG0330	HflC and HflK could
IE977_RS02300	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
IE977_RS02310	COG1959	2 iron, 2 sulfur cluster binding
IE977_RS02315	COG0557	exoribonuclease II activity
IE977_RS02320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IE977_RS02325	COG0477	Major facilitator Superfamily
IE977_RS02330	COG1960	acyl-CoA dehydrogenase activity
IE977_RS02345	COG3650	response to hydrogen peroxide
IE977_RS02350	COG1073	alpha beta
IE977_RS02365	COG3037	sugar-specific permease SgaT UlaA
IE977_RS02405	COG2965	DNA replication, synthesis of RNA primer
IE977_RS02410	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IE977_RS02415	COG0359	binds to the 23S rRNA
IE977_RS02420	COG0697	spore germination
IE977_RS02425	COG3061	Opacity-associated protein A
IE977_RS02430	COG0545	Peptidyl-prolyl cis-trans isomerase
IE977_RS02435	COG1113	amino acid transport
IE977_RS02445	COG0840	transmembrane signaling receptor activity
IE977_RS02450	COG0697	spore germination
IE977_RS02460	COG0702	epimerase
IE977_RS02465	COG1733	regulation of RNA biosynthetic process
IE977_RS02475	COG1218	3'(2'),5'-bisphosphate nucleotidase
IE977_RS02480	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
IE977_RS02490	COG1253	flavin adenine dinucleotide binding
IE977_RS02495	COG2211	Major facilitator Superfamily
IE977_RS02500	COG0673	inositol 2-dehydrogenase activity
IE977_RS02510	COG0673	inositol 2-dehydrogenase activity
IE977_RS02515	COG0673	inositol 2-dehydrogenase activity
IE977_RS02520	COG1609	Transcriptional regulator
IE977_RS02525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IE977_RS02530	COG0729	surface antigen
IE977_RS02535	COG2911	Protein conserved in bacteria
IE977_RS02540	COG2105	PFAM AIG2 family protein
IE977_RS02550	COG1879	ABC-type sugar transport system periplasmic component
IE977_RS02555	COG1129	ABC transporter
IE977_RS02560	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS02565	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS02580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IE977_RS02585	COG3028	Belongs to the UPF0307 family
IE977_RS02590	COG0312	modulator of DNA gyrase
IE977_RS02630	COG3964	amidohydrolase
IE977_RS02650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS02650	COG3711	transcriptional antiterminator
IE977_RS02655	COG0602	queuosine metabolic process
IE977_RS02665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE977_RS02665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS02665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE977_RS02670	COG0383	alpha-mannosidase activity
IE977_RS02690	COG0366	Alpha amylase catalytic
IE977_RS02695	COG1263	PTS System
IE977_RS02695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS02700	COG1609	Transcriptional regulator
IE977_RS02710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
IE977_RS02715	COG3397	chitin binding
IE977_RS02720	COG0251	oxidation-reduction process
IE977_RS02730	COG0540	Belongs to the ATCase OTCase family
IE977_RS02745	COG1438	arginine binding
IE977_RS02750	COG1288	antiporter activity
IE977_RS02765	COG2235	arginine
IE977_RS02770	COG2731	YhcH YjgK YiaL family protein
IE977_RS02775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE977_RS02780	COG0129	dihydroxy-acid dehydratase activity
IE977_RS02785	COG2211	Major facilitator Superfamily
IE977_RS02790	COG3507	Belongs to the glycosyl hydrolase 43 family
IE977_RS02795	COG1414	Transcriptional regulator
IE977_RS02800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IE977_RS02825	COG0582	viral genome integration into host DNA
IE977_RS02885	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
IE977_RS02905	COG1196	nuclear chromosome segregation
IE977_RS02960	COG1609	Transcriptional regulator
IE977_RS02970	COG2211	Major facilitator Superfamily
IE977_RS02995	COG1335	isochorismatase
IE977_RS03010	COG2204	response regulator
IE977_RS03015	COG4191	Histidine kinase
IE977_RS03020	COG4566	intracellular signal transduction
IE977_RS03025	COG0346	lactoylglutathione lyase activity
IE977_RS03030	COG0740	serine-type endopeptidase activity
IE977_RS03035	COG2850	peptidyl-arginine hydroxylation
IE977_RS03060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE977_RS03065	COG5457	Domain of unknown function (DUF1127)
IE977_RS03075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE977_RS03090	COG0640	Transcriptional regulator
IE977_RS03100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE977_RS03110	COG2733	membrane
IE977_RS03125	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS03140	COG0523	cobalamin synthesis protein
IE977_RS03145	COG2879	small protein
IE977_RS03150	COG1966	Carbon starvation protein
IE977_RS03155	COG1349	DNA-binding transcription factor activity
IE977_RS03160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IE977_RS03165	COG2368	4-hydroxyphenylacetate
IE977_RS03185	COG3971	2-oxopent-4-enoate hydratase activity
IE977_RS03195	COG3384	dioxygenase
IE977_RS03200	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS03205	COG0179	Fumarylacetoacetate (FAA) hydrolase
IE977_RS03210	COG1846	Transcriptional regulator
IE977_RS03215	COG0840	transmembrane signaling receptor activity
IE977_RS03235	COG1484	DNA-dependent DNA replication
IE977_RS03245	COG1764	response to oxidative stress
IE977_RS03250	COG1846	Transcriptional regulator
IE977_RS03255	COG3610	response to peptide
IE977_RS03260	COG2966	Psort location CytoplasmicMembrane, score
IE977_RS03265	COG2197	response regulator
IE977_RS03270	COG2197	response regulator
IE977_RS03275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IE977_RS03280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE977_RS03280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE977_RS03285	COG4114	ferric iron reductase
IE977_RS03315	COG2813	Specifically methylates the guanine in position
IE977_RS03320	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IE977_RS03325	COG0456	acetyltransferase
IE977_RS03330	COG1011	Hydrolase
IE977_RS03335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IE977_RS03340	COG2823	Periplasmic or secreted lipoprotein
IE977_RS03345	COG5487	UPF0391 membrane protein
IE977_RS03350	COG4667	esterase of the alpha-beta hydrolase superfamily
IE977_RS03355	COG0084	hydrolase, TatD family'
IE977_RS03360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IE977_RS03365	COG1328	CTP reductase activity
IE977_RS03375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IE977_RS03395	COG3726	membrane protein affecting hemolysin expression
IE977_RS03400	COG0560	Phosphoserine phosphatase
IE977_RS03425	COG0488	(ABC) transporter
IE977_RS03430	COG0741	lytic transglycosylase activity
IE977_RS03435	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
IE977_RS03440	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
IE977_RS03445	COG0406	alpha-ribazole phosphatase activity
IE977_RS03450	COG3708	Transcriptional regulator
IE977_RS03450	COG2207	Transcriptional regulator
IE977_RS03455	COG3045	CreA protein
IE977_RS03460	COG0745	RESPONSE REGULATOR receiver
IE977_RS03470	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IE977_RS03480	COG0527	aspartate kinase activity
IE977_RS03480	COG0460	homoserine dehydrogenase
IE977_RS03490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IE977_RS03505	COG1115	amino acid carrier protein
IE977_RS03515	COG0521	Mo-molybdopterin cofactor biosynthetic process
IE977_RS03520	COG0477	Major facilitator Superfamily
IE977_RS03525	COG1584	GPR1 FUN34 yaaH family protein
IE977_RS03530	COG0443	Heat shock 70 kDa protein
IE977_RS03540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IE977_RS03545	COG0583	DNA-binding transcription factor activity
IE977_RS03550	COG0268	Binds directly to 16S ribosomal RNA
IE977_RS03555	COG0196	riboflavin kinase activity
IE977_RS03570	COG1047	Peptidyl-prolyl cis-trans
IE977_RS03590	COG3716	PTS system mannose fructose sorbose family IID component
IE977_RS03595	COG3715	PTS system
IE977_RS03600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS03615	COG1609	Transcriptional regulator
IE977_RS03625	COG0505	Belongs to the CarA family
IE977_RS03645	COG2249	NAD(P)H dehydrogenase (quinone) activity
IE977_RS03650	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IE977_RS03650	COG0475	glutathione-regulated potassium exporter activity
IE977_RS03660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IE977_RS03665	COG2967	ApaG domain
IE977_RS03675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IE977_RS03680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IE977_RS03685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IE977_RS03690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IE977_RS03695	COG0564	pseudouridine synthase activity
IE977_RS03700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IE977_RS03705	COG0417	DNA replication proofreading
IE977_RS03710	COG0235	Class ii aldolase
IE977_RS03715	COG2160	L-arabinose isomerase activity
IE977_RS03720	COG1069	ribulokinase activity
IE977_RS03730	COG0586	Pfam SNARE associated Golgi protein
IE977_RS03740	COG1178	ABC-type Fe3 transport system permease component
IE977_RS03760	COG2814	Major facilitator Superfamily
IE977_RS03785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IE977_RS03800	COG0028	Belongs to the TPP enzyme family
IE977_RS03810	COG1609	Transcriptional regulator
IE977_RS03815	COG2001	Belongs to the MraZ family
IE977_RS03830	COG0768	penicillin binding
IE977_RS03835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IE977_RS03840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IE977_RS03845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IE977_RS03855	COG0772	Belongs to the SEDS family
IE977_RS03870	COG1181	Belongs to the D-alanine--D-alanine ligase family
IE977_RS03880	COG0849	cell division
IE977_RS03885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IE977_RS03890	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IE977_RS03900	COG0653	protein targeting
IE977_RS03905	COG0494	nUDIX hydrolase
IE977_RS03910	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IE977_RS03915	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IE977_RS03925	COG0516	GMP reductase activity
IE977_RS03930	COG1459	type II secretion system
IE977_RS03935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IE977_RS03940	COG4969	Belongs to the N-Me-Phe pilin family
IE977_RS03950	COG3023	N-Acetylmuramoyl-L-alanine amidase
IE977_RS03955	COG3725	Membrane protein required for beta-lactamase induction
IE977_RS03960	COG3940	Belongs to the glycosyl hydrolase 43 family
IE977_RS03965	COG2211	Major facilitator Superfamily
IE977_RS03970	COG1113	amino acid transport
IE977_RS03975	COG2186	Transcriptional regulator
IE977_RS03980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IE977_RS03985	COG0508	dehydrogenase complex catalyzes the overall conversion of
IE977_RS03990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IE977_RS04000	COG3064	Membrane
IE977_RS04020	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IE977_RS04035	COG4993	Dehydrogenase
IE977_RS04045	COG0288	reversible hydration of carbon dioxide
IE977_RS04050	COG1131	(ABC) transporter
IE977_RS04055	COG0842	Transport permease protein
IE977_RS04060	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS04065	COG0726	polysaccharide deacetylase
IE977_RS04085	COG3539	Fimbrial protein
IE977_RS04090	COG3188	usher protein
IE977_RS04095	COG3121	Chaperone
IE977_RS04105	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IE977_RS04110	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IE977_RS04120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IE977_RS04125	COG0617	tRNA 3'-terminal CCA addition
IE977_RS04130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IE977_RS04140	COG1489	DNA binding
IE977_RS04145	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IE977_RS04150	COG1643	Atp-dependent helicase
IE977_RS04155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IE977_RS04165	COG3121	Chaperone
IE977_RS04170	COG3188	usher protein
IE977_RS04180	COG4774	siderophore transport
IE977_RS04185	COG1120	ATPase activity
IE977_RS04190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IE977_RS04195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE977_RS04200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IE977_RS04210	COG0316	Belongs to the HesB IscA family
IE977_RS04215	COG2860	membrane
IE977_RS04225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IE977_RS04230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IE977_RS04235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE977_RS04240	COG3835	regulator
IE977_RS04285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IE977_RS04295	COG0575	Belongs to the CDS family
IE977_RS04300	COG0750	zinc metalloprotease
IE977_RS04305	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IE977_RS04315	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IE977_RS04320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IE977_RS04325	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IE977_RS04330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IE977_RS04335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IE977_RS04345	COG0825	malonyl-CoA metabolic process
IE977_RS04350	COG1982	Orn Lys Arg decarboxylase major
IE977_RS04355	COG0346	lactoylglutathione lyase activity
IE977_RS04360	COG0037	tRNA processing
IE977_RS04365	COG4568	rho-dependent transcription termination
IE977_RS04380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IE977_RS04385	COG3015	lipoprotein NlpE involved in copper resistance
IE977_RS04395	COG1720	tRNA m6t6A37 methyltransferase activity
IE977_RS04405	COG1464	Belongs to the NlpA lipoprotein family
IE977_RS04410	COG2011	ABC-type metal ion transport system permease component
IE977_RS04420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IE977_RS04460	COG0583	DNA-binding transcription factor activity
IE977_RS04465	COG2814	Major facilitator Superfamily
IE977_RS04470	COG3021	interspecies interaction between organisms
IE977_RS04475	COG2226	methyltransferase
IE977_RS04480	COG0741	lytic transglycosylase activity
IE977_RS04480	COG1388	LysM domain
IE977_RS04485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE977_RS04490	COG2226	methyltransferase
IE977_RS04515	COG0444	Belongs to the ABC transporter superfamily
IE977_RS04520	COG4608	Belongs to the ABC transporter superfamily
IE977_RS04525	COG0747	negative chemotaxis
IE977_RS04535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE977_RS04545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IE977_RS04550	COG1960	acyl-CoA dehydrogenase activity
IE977_RS04560	COG0121	glutamine amidotransferase
IE977_RS04565	COG3034	peptidoglycan biosynthetic process
IE977_RS04580	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IE977_RS04585	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
IE977_RS04600	COG2991	Protein conserved in bacteria
IE977_RS04605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IE977_RS04610	COG2195	Cleaves the N-terminal amino acid of tripeptides
IE977_RS04620	COG1073	alpha beta
IE977_RS04630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IE977_RS04635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IE977_RS04640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IE977_RS04650	COG0582	viral genome integration into host DNA
IE977_RS04670	COG3561	AntA/AntB antirepressor
IE977_RS04730	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IE977_RS04740	COG5001	Diguanylate cyclase
IE977_RS04740	COG3300	MHYT domain
IE977_RS04755	COG0628	permease
IE977_RS04765	COG2040	homocysteine
IE977_RS04770	COG4521	taurine ABC transporter
IE977_RS04775	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IE977_RS04780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE977_RS04785	COG2175	clavaminate synthase activity
IE977_RS04795	COG0113	porphobilinogen synthase activity
IE977_RS04810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IE977_RS04815	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IE977_RS04835	COG1181	Belongs to the D-alanine--D-alanine ligase family
IE977_RS04860	COG3706	GGDEF domain
IE977_RS04865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IE977_RS04870	COG1671	Belongs to the UPF0178 family
IE977_RS04875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IE977_RS04885	COG4126	flavin adenine dinucleotide binding
IE977_RS04890	COG3123	guanosine phosphorylase activity
IE977_RS04900	COG1940	carbohydrate kinase activity
IE977_RS04905	COG0419	ATPase involved in DNA repair
IE977_RS04910	COG0420	3'-5' exonuclease activity
IE977_RS04920	COG5002	protein histidine kinase activity
IE977_RS04935	COG0366	Alpha amylase catalytic
IE977_RS04950	COG0450	alkyl hydroperoxide reductase
IE977_RS04955	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
IE977_RS04970	COG1862	Preprotein translocase
IE977_RS04975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IE977_RS04980	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IE977_RS04995	COG3248	Nucleoside-binding outer membrane protein
IE977_RS05000	COG4238	major outer membrane lipoprotein
IE977_RS05005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IE977_RS05010	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IE977_RS05010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IE977_RS05015	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IE977_RS05020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IE977_RS05025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IE977_RS05030	COG0667	Aldo Keto reductase
IE977_RS05035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IE977_RS05040	COG0142	geranyltranstransferase activity
IE977_RS05055	COG2188	Transcriptional regulator
IE977_RS05065	COG1486	melibiose metabolic process
IE977_RS05070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE977_RS05075	COG0693	protein deglycase activity
IE977_RS05080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IE977_RS05090	COG2814	Major facilitator Superfamily
IE977_RS05095	COG0235	Class ii aldolase
IE977_RS05115	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS05120	COG1129	ABC transporter
IE977_RS05140	COG0109	protoheme IX farnesyltransferase activity
IE977_RS05145	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IE977_RS05150	COG1845	cytochrome c oxidase, subunit III
IE977_RS05155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IE977_RS05160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IE977_RS05165	COG2223	nitrite transmembrane transporter activity
IE977_RS05170	COG3056	Lipoprotein
IE977_RS05175	COG0271	Belongs to the BolA IbaG family
IE977_RS05180	COG0544	peptidyl-prolyl cis-trans isomerase activity
IE977_RS05195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IE977_RS05200	COG0776	regulation of translation
IE977_RS05205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IE977_RS05210	COG1555	photosystem II stabilization
IE977_RS05215	COG0824	Thioesterase
IE977_RS05220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IE977_RS05225	COG4533	DNA binding
IE977_RS05230	COG0561	phosphatase activity
IE977_RS05240	COG1522	sequence-specific DNA binding
IE977_RS05245	COG1132	(ABC) transporter
IE977_RS05250	COG1132	(ABC) transporter
IE977_RS05255	COG0347	Belongs to the P(II) protein family
IE977_RS05260	COG0004	ammonium transporteR
IE977_RS05265	COG1946	Acyl-CoA thioesterase
IE977_RS05270	COG3126	Type III secretion system lipoprotein chaperone (YscW)
IE977_RS05275	COG3695	enzyme binding
IE977_RS05300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE977_RS05305	COG2364	Membrane
IE977_RS05310	COG1609	Transcriptional regulator
IE977_RS05330	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IE977_RS05340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IE977_RS05360	COG0110	maltose O-acetyltransferase activity
IE977_RS05375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE977_RS05380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE977_RS05385	COG1309	transcriptional regulator
IE977_RS05390	COG1196	nuclear chromosome segregation
IE977_RS05390	COG3264	Mechanosensitive ion channel
IE977_RS05400	COG3923	Primosomal replication protein n
IE977_RS05405	COG2832	Protein of unknown function (DUF454)
IE977_RS05410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IE977_RS05420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IE977_RS05425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IE977_RS05430	COG0326	Molecular chaperone. Has ATPase activity
IE977_RS05440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IE977_RS05445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE977_RS05450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IE977_RS05450	COG4651	solute:proton antiporter activity
IE977_RS05455	COG2223	nitrite transmembrane transporter activity
IE977_RS05460	COG0737	Belongs to the 5'-nucleotidase family
IE977_RS05465	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IE977_RS05470	COG3735	TraB family
IE977_RS05475	COG2217	Heavy metal translocating P-type atpase
IE977_RS05485	COG1585	Membrane protein implicated in regulation of membrane protease activity
IE977_RS05490	COG0330	HflC and HflK could
IE977_RS05500	COG4619	ABC transporter
IE977_RS05505	COG0390	transport system, permease component
IE977_RS05510	COG3118	belongs to the thioredoxin family
IE977_RS05515	COG0300	oxidoreductase activity
IE977_RS05520	COG2755	lipolytic protein G-D-S-L family
IE977_RS05525	COG4181	ATPase activity
IE977_RS05530	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IE977_RS05545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IE977_RS05550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IE977_RS05555	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IE977_RS05560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IE977_RS05570	COG1988	membrane-bound metal-dependent
IE977_RS05575	COG1609	Transcriptional regulator
IE977_RS05580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS05580	COG1263	PTS System
IE977_RS05580	COG2190	(PTS) system
IE977_RS05585	COG2501	S4 domain
IE977_RS05645	COG0582	viral genome integration into host DNA
IE977_RS05775	COG2246	polysaccharide biosynthetic process
IE977_RS05790	COG2135	peptidase activity
IE977_RS05810	COG1113	amino acid transport
IE977_RS05815	COG2211	Major facilitator Superfamily
IE977_RS05830	COG1609	Transcriptional regulator
IE977_RS05835	COG0668	transmembrane transport
IE977_RS05840	COG0477	Major facilitator Superfamily
IE977_RS05855	COG0778	Nitroreductase
IE977_RS05860	COG2315	Protein conserved in bacteria
IE977_RS05880	COG4774	siderophore transport
IE977_RS05910	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IE977_RS05925	COG5499	transcription regulator containing HTH domain
IE977_RS05930	COG4680	protein conserved in bacteria
IE977_RS05980	COG4608	Belongs to the ABC transporter superfamily
IE977_RS05985	COG0444	Belongs to the ABC transporter superfamily
IE977_RS05990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE977_RS05995	COG0601	transmembrane transport
IE977_RS06010	COG3415	Transposase
IE977_RS06010	COG2801	Transposase and inactivated derivatives
IE977_RS06030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IE977_RS06060	COG1121	(ABC) transporter
IE977_RS06065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE977_RS06070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE977_RS06075	COG2977	Belongs to the P-Pant transferase superfamily
IE977_RS06080	COG4771	TonB-dependent receptor
IE977_RS06085	COG2382	esterase
IE977_RS06090	COG3251	PFAM MbtH domain protein
IE977_RS06095	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IE977_RS06095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IE977_RS06100	COG1120	ATPase activity
IE977_RS06105	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE977_RS06110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE977_RS06120	COG4592	Periplasmic binding protein
IE977_RS06125	COG1169	isochorismate synthase
IE977_RS06130	COG1021	2,3-dihydroxybenzoate-AMP ligase
IE977_RS06135	COG3433	isochorismatase activity
IE977_RS06135	COG1535	isochorismatase
IE977_RS06140	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS06145	COG2050	protein possibly involved in aromatic compounds catabolism
IE977_RS06150	COG1966	Carbon starvation protein
IE977_RS06155	COG2879	small protein
IE977_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS06175	COG0371	Dehydrogenase
IE977_RS06180	COG1129	ABC transporter
IE977_RS06185	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS06200	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
IE977_RS06220	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IE977_RS06225	COG0235	Class ii aldolase
IE977_RS06230	COG0436	Aminotransferase
IE977_RS06235	COG1475	DNA binding
IE977_RS06240	COG3969	phosphoadenosine phosphosulfate
IE977_RS06245	COG0583	DNA-binding transcription factor activity
IE977_RS06265	COG1063	alcohol dehydrogenase
IE977_RS06270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IE977_RS06280	COG2207	Transcriptional regulator
IE977_RS06285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IE977_RS06285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS06285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS06290	COG1363	Peptidase, m42
IE977_RS06295	COG0006	proline dipeptidase activity
IE977_RS06300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE977_RS06305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE977_RS06310	COG3719	Belongs to the RNase T2 family
IE977_RS06315	COG3069	C4-dicarboxylate transmembrane transporter activity
IE977_RS06335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE977_RS06340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE977_RS06360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IE977_RS06365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IE977_RS06370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IE977_RS06375	COG0583	DNA-binding transcription factor activity
IE977_RS06380	COG0321	lipoyl(octanoyl) transferase activity
IE977_RS06390	COG1686	Belongs to the peptidase S11 family
IE977_RS06395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IE977_RS06400	COG0772	Belongs to the SEDS family
IE977_RS06405	COG0768	penicillin binding
IE977_RS06415	COG0799	negative regulation of ribosome biogenesis
IE977_RS06425	COG1466	dna polymerase III delta subunit
IE977_RS06440	COG2888	peptidyl-tyrosine sulfation
IE977_RS06445	COG1957	nucleoside hydrolase
IE977_RS06450	COG1126	abc transporter atp-binding protein
IE977_RS06455	COG0765	amino acid transport
IE977_RS06460	COG0765	amino acid transport
IE977_RS06480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IE977_RS06485	COG1702	phosphate starvation-inducible protein PhoH
IE977_RS06490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IE977_RS06495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IE977_RS06535	COG0367	asparagine synthase
IE977_RS06540	COG0647	UMP catabolic process
IE977_RS06545	COG1846	Transcriptional regulator
IE977_RS06545	COG1940	carbohydrate kinase activity
IE977_RS06550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IE977_RS06560	COG2190	(PTS) system
IE977_RS06560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS06560	COG1263	PTS System
IE977_RS06565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IE977_RS06580	COG0735	belongs to the Fur family
IE977_RS06595	COG0596	Alpha beta hydrolase
IE977_RS06600	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
IE977_RS06605	COG0033	Phosphoglucomutase
IE977_RS06610	COG0531	amino acid
IE977_RS06615	COG1982	Orn Lys Arg decarboxylase major
IE977_RS06625	COG0745	RESPONSE REGULATOR receiver
IE977_RS06630	COG2205	protein histidine kinase activity
IE977_RS06635	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IE977_RS06640	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IE977_RS06645	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IE977_RS06660	COG0415	Belongs to the DNA photolyase family
IE977_RS06665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IE977_RS06670	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IE977_RS06675	COG1984	allophanate hydrolase subunit 2
IE977_RS06685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IE977_RS06690	COG0372	Belongs to the citrate synthase family
IE977_RS06695	COG2009	succinate dehydrogenase
IE977_RS06700	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IE977_RS06705	COG1053	succinate dehydrogenase
IE977_RS06710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IE977_RS06715	COG0567	Dehydrogenase, E1 component
IE977_RS06720	COG0508	dehydrogenase complex catalyzes the overall conversion of
IE977_RS06725	COG0045	succinate-CoA ligase (ADP-forming) activity
IE977_RS06730	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IE977_RS06735	COG2188	Transcriptional regulator
IE977_RS06740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE977_RS06740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS06740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE977_RS06745	COG0383	alpha-mannosidase activity
IE977_RS06750	COG1271	oxidase subunit
IE977_RS06755	COG1294	oxidase, subunit
IE977_RS06760	COG4890	Cyd operon protein YbgT
IE977_RS06765	COG3790	cyd operon protein YbgE
IE977_RS06770	COG0824	Thioesterase
IE977_RS06775	COG0811	peptide transport
IE977_RS06780	COG0848	biopolymer transport protein
IE977_RS06785	COG3064	Membrane
IE977_RS06790	COG0823	Involved in the tonB-independent uptake of proteins
IE977_RS06795	COG2885	chlorophyll binding
IE977_RS06800	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IE977_RS06835	COG3201	nicotinamide mononucleotide transporter
IE977_RS06840	COG1230	cation diffusion facilitator family transporter
IE977_RS06850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IE977_RS06860	COG2017	converts alpha-aldose to the beta-anomer
IE977_RS06865	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IE977_RS06870	COG1085	galactose-1-phosphate uridylyltransferase
IE977_RS06875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IE977_RS06880	COG1119	ATPase activity
IE977_RS06885	COG3585	molybdate ion transport
IE977_RS06885	COG2005	Transcriptional regulator
IE977_RS06895	COG0725	ABC transporter, periplasmic molybdate-binding protein
IE977_RS06900	COG4149	molybdate abc transporter
IE977_RS06910	COG0561	phosphatase activity
IE977_RS06915	COG2706	6-phosphogluconolactonase activity
IE977_RS06920	COG4677	pectinesterase activity
IE977_RS06930	COG0010	Belongs to the arginase family
IE977_RS06940	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IE977_RS06945	COG2986	histidine ammonia-lyase
IE977_RS06950	COG1881	PFAM PEBP family protein
IE977_RS06955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IE977_RS06960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IE977_RS06965	COG0156	8-amino-7-oxononanoate synthase activity
IE977_RS06970	COG2226	methyltransferase
IE977_RS06990	COG3415	Transposase
IE977_RS06990	COG2801	Transposase and inactivated derivatives
IE977_RS07005	COG0521	Mo-molybdopterin cofactor biosynthetic process
IE977_RS07010	COG0315	cyclic pyranopterin monophosphate synthase activity
IE977_RS07015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IE977_RS07020	COG0314	molybdopterin synthase activity
IE977_RS07025	COG0670	Belongs to the BI1 family
IE977_RS07030	COG0392	lysyltransferase activity
IE977_RS07035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IE977_RS07040	COG3568	Endonuclease Exonuclease Phosphatase
IE977_RS07050	COG0842	Transport permease protein
IE977_RS07055	COG0842	Transport permease protein
IE977_RS07060	COG1131	(ABC) transporter
IE977_RS07065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE977_RS07070	COG1309	transcriptional regulator
IE977_RS07075	COG0513	Belongs to the DEAD box helicase family
IE977_RS07080	COG1199	ATP-dependent helicase activity
IE977_RS07100	COG3121	Chaperone
IE977_RS07110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IE977_RS07120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IE977_RS07130	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
IE977_RS07135	COG0668	transmembrane transport
IE977_RS07140	COG1126	abc transporter atp-binding protein
IE977_RS07145	COG0765	amino acid transport
IE977_RS07150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE977_RS07155	COG0783	Belongs to the Dps family
IE977_RS07165	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IE977_RS07170	COG2194	sulfuric ester hydrolase activity
IE977_RS07180	COG1321	iron dependent repressor
IE977_RS07185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IE977_RS07190	COG1566	PFAM secretion protein HlyD family protein
IE977_RS07195	COG2814	Major facilitator Superfamily
IE977_RS07205	COG0667	Aldo Keto reductase
IE977_RS07215	COG2819	hydrolase of the alpha beta superfamily
IE977_RS07220	COG2382	esterase
IE977_RS07235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE977_RS07245	COG1538	Outer membrane efflux protein
IE977_RS07250	COG2723	6-phospho-beta-galactosidase activity
IE977_RS07255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE977_RS07260	COG2188	Transcriptional regulator
IE977_RS07265	COG1376	ErfK ybiS ycfS ynhG family protein
IE977_RS07270	COG0488	(ABC) transporter
IE977_RS07280	COG2271	Major facilitator Superfamily
IE977_RS07285	COG1609	Transcriptional regulator
IE977_RS07295	COG0561	phosphatase activity
IE977_RS07300	COG1882	Formate acetyltransferase
IE977_RS07305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IE977_RS07310	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IE977_RS07320	COG0303	'Molybdopterin
IE977_RS07325	COG1446	asparaginase
IE977_RS07360	COG2133	pyrroloquinoline quinone binding
IE977_RS07365	COG0625	glutathione transferase activity
IE977_RS07370	COG1686	Belongs to the peptidase S11 family
IE977_RS07375	COG1349	DNA-binding transcription factor activity
IE977_RS07380	COG0671	phosphoesterase, PA-phosphatase related
IE977_RS07390	COG2814	Major facilitator Superfamily
IE977_RS07395	COG0561	phosphatase activity
IE977_RS07400	COG0738	Major facilitator superfamily
IE977_RS07405	COG3226	Transcriptional regulator
IE977_RS07410	COG1393	Belongs to the ArsC family
IE977_RS07415	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IE977_RS07420	COG0640	Transcriptional regulator
IE977_RS07465	COG0778	Nitroreductase
IE977_RS07480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IE977_RS07485	COG3842	ATPase activity
IE977_RS07490	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE977_RS07495	COG1177	transmembrane transport
IE977_RS07505	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IE977_RS07510	COG0745	RESPONSE REGULATOR receiver
IE977_RS07515	COG5002	protein histidine kinase activity
IE977_RS07520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE977_RS07525	COG4160	amino acid transport
IE977_RS07530	COG4215	(ABC) transporter
IE977_RS07535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE977_RS07540	COG1126	abc transporter atp-binding protein
IE977_RS07550	COG0393	Putative heavy-metal-binding
IE977_RS07555	COG3023	N-Acetylmuramoyl-L-alanine amidase
IE977_RS07575	COG3031	protein transport across the cell outer membrane
IE977_RS07580	COG1450	Type ii and iii secretion system protein
IE977_RS07585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IE977_RS07595	COG2165	general secretion pathway protein
IE977_RS07605	COG2165	general secretion pathway protein
IE977_RS07630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IE977_RS07645	COG3397	chitin binding
IE977_RS07650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IE977_RS07655	COG0702	epimerase
IE977_RS07660	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IE977_RS07665	COG0028	Belongs to the TPP enzyme family
IE977_RS07680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IE977_RS07685	COG1151	hydroxylamine reductase activity
IE977_RS07690	COG2431	L-lysine efflux transmembrane transporter activity
IE977_RS07700	COG3593	DNA synthesis involved in DNA repair
IE977_RS07705	COG2990	Protein conserved in bacteria
IE977_RS07710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE977_RS07720	COG1278	Cold shock
IE977_RS07725	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IE977_RS07730	COG0542	response to heat
IE977_RS07735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IE977_RS07740	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IE977_RS07745	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IE977_RS07750	COG4988	ABC transporter
IE977_RS07755	COG0492	ferredoxin-NADP+ reductase activity
IE977_RS07765	COG1178	ABC-type Fe3 transport system permease component
IE977_RS07765	COG1674	ftsk spoiiie
IE977_RS07770	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IE977_RS07775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IE977_RS07780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IE977_RS07785	COG0243	molybdopterin cofactor binding
IE977_RS07790	COG0437	4 iron, 4 sulfur cluster binding
IE977_RS07795	COG3302	dmso reductase anchor subunit
IE977_RS07800	COG0477	Major facilitator Superfamily
IE977_RS07810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IE977_RS07815	COG1882	Formate acetyltransferase
IE977_RS07820	COG2116	formate transmembrane transporter activity
IE977_RS07825	COG1944	ATP diphosphatase activity
IE977_RS07830	COG2323	membrane
IE977_RS07835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IE977_RS07840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IE977_RS07845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IE977_RS07850	COG0539	negative regulation of cytoplasmic translation
IE977_RS07855	COG0776	regulation of translation
IE977_RS07865	COG1132	(ABC) transporter
IE977_RS07875	COG3214	Protein conserved in bacteria
IE977_RS07880	COG2835	tetraacyldisaccharide 4'-kinase activity
IE977_RS07885	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IE977_RS07890	COG3173	Aminoglycoside phosphotransferase
IE977_RS07895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IE977_RS07900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IE977_RS07910	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
IE977_RS07915	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IE977_RS07920	COG2989	Protein conserved in bacteria
IE977_RS07925	COG3108	Peptidase M15
IE977_RS07930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE977_RS07935	COG1448	Aminotransferase
IE977_RS07945	COG0017	Asparaginyl-tRNA synthetase
IE977_RS07950	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IE977_RS07955	COG0582	viral genome integration into host DNA
IE977_RS08025	COG4626	Terminase
IE977_RS08025	COG1802	Transcriptional regulator
IE977_RS08030	COG1484	DNA-dependent DNA replication
IE977_RS08035	COG0305	Participates in initiation and elongation during chromosome replication
IE977_RS08040	COG0484	heat shock protein binding
IE977_RS08075	COG3179	chitinase
IE977_RS08125	COG4626	Terminase
IE977_RS08125	COG1802	Transcriptional regulator
IE977_RS08130	COG4695	Portal protein
IE977_RS08135	COG0740	serine-type endopeptidase activity
IE977_RS08230	COG0308	aminopeptidase N
IE977_RS08240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IE977_RS08245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE977_RS08250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE977_RS08255	COG0431	NADPH-dependent FMN reductase
IE977_RS08260	COG0167	dihydroorotate dehydrogenase activity
IE977_RS08270	COG0633	Ferredoxin
IE977_RS08270	COG3217	Mosc domain protein beta barrel domain protein
IE977_RS08275	COG0116	Belongs to the methyltransferase superfamily
IE977_RS08275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IE977_RS08280	COG0488	(ABC) transporter
IE977_RS08285	COG2995	paraquat-inducible protein a
IE977_RS08290	COG3008	intermembrane lipid transfer
IE977_RS08290	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IE977_RS08295	COG3009	Protein conserved in bacteria
IE977_RS08300	COG3130	regulation of translation
IE977_RS08310	COG1067	ATP-dependent peptidase activity
IE977_RS08315	COG3120	sequence-specific DNA binding
IE977_RS08325	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
IE977_RS08330	COG3070	regulator of competence-specific genes
IE977_RS08335	COG1289	transmembrane transporter activity
IE977_RS08340	COG3304	Inner membrane component domain
IE977_RS08345	COG0210	DNA helicase
IE977_RS08350	COG1803	Methylglyoxal synthase
IE977_RS08355	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IE977_RS08360	COG1832	CoA-binding protein
IE977_RS08370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IE977_RS08375	COG1254	Belongs to the acylphosphatase family
IE977_RS08385	COG0670	Belongs to the BI1 family
IE977_RS08400	COG1120	ATPase activity
IE977_RS08405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE977_RS08415	COG3264	Mechanosensitive ion channel
IE977_RS08415	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
IE977_RS08430	COG2239	Acts as a magnesium transporter
IE977_RS08435	COG3039	Transposase
IE977_RS08440	COG0586	Pfam SNARE associated Golgi protein
IE977_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS08450	COG1733	regulation of RNA biosynthetic process
IE977_RS08475	COG3729	General stress protein
IE977_RS08485	COG2233	PERMEase
IE977_RS08490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IE977_RS08495	COG0778	Nitroreductase
IE977_RS08500	COG2267	carboxylic ester hydrolase activity
IE977_RS08505	COG0251	oxidation-reduction process
IE977_RS08510	COG1335	isochorismatase
IE977_RS08515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE977_RS08540	COG1309	transcriptional regulator
IE977_RS08550	COG0506	proline dehydrogenase activity
IE977_RS08550	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IE977_RS08550	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IE977_RS08555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IE977_RS08565	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IE977_RS08575	COG2822	iron ion transport
IE977_RS08585	COG1702	phosphate starvation-inducible protein PhoH
IE977_RS08590	COG1115	amino acid carrier protein
IE977_RS08600	COG1335	isochorismatase
IE977_RS08610	COG0583	DNA-binding transcription factor activity
IE977_RS08620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IE977_RS08625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IE977_RS08630	COG3381	protein complex oligomerization
IE977_RS08680	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IE977_RS08695	COG2943	transferase activity, transferring hexosyl groups
IE977_RS08700	COG5645	(Lipo)protein
IE977_RS08715	COG1560	Kdo2-lipid A biosynthetic process
IE977_RS08720	COG1054	Belongs to the UPF0176 family
IE977_RS08725	COG2353	YceI-like domain
IE977_RS08730	COG3038	cytochrome b561
IE977_RS08755	COG0418	dihydroorotase activity
IE977_RS08765	COG0477	Major facilitator Superfamily
IE977_RS08770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE977_RS08775	COG3132	Protein of unknown function, DUF480
IE977_RS08810	COG1558	bacterial-type flagellum-dependent cell motility
IE977_RS08820	COG1749	Flagellar hook protein flgE
IE977_RS08830	COG4786	Flagellar basal body rod
IE977_RS08850	COG1256	bacterial-type flagellum assembly
IE977_RS08860	COG2814	Major facilitator Superfamily
IE977_RS08865	COG0583	DNA-binding transcription factor activity
IE977_RS08870	COG1530	ribonuclease E activity
IE977_RS08875	COG0564	pseudouridine synthase activity
IE977_RS08880	COG0424	maF-like protein
IE977_RS08890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IE977_RS08895	COG0416	fatty acid biosynthetic process
IE977_RS08900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IE977_RS08915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IE977_RS08920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE977_RS08925	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IE977_RS08930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IE977_RS08935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IE977_RS08940	COG0470	DNA polymerase III
IE977_RS08945	COG0084	hydrolase, TatD family'
IE977_RS08955	COG4773	Receptor
IE977_RS08960	COG0537	adenosine 5'-monophosphoramidase activity
IE977_RS08965	COG5633	Lipoprotein
IE977_RS08970	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
IE977_RS08985	COG3150	esterase
IE977_RS08990	COG1252	NADH dehydrogenase
IE977_RS08995	COG3134	Outer membrane lipoprotein
IE977_RS09000	COG1309	transcriptional regulator
IE977_RS09010	COG1376	ErfK ybiS ycfS ynhG family protein
IE977_RS09010	COG1388	LysM domain
IE977_RS09015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IE977_RS09020	COG4763	Acyl-transferase
IE977_RS09025	COG4591	ABC-type transport system involved in lipoprotein release permease component
IE977_RS09030	COG1136	(ABC) transporter
IE977_RS09035	COG4591	ABC-type transport system involved in lipoprotein release permease component
IE977_RS09045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IE977_RS09075	COG1943	Transposase
IE977_RS09080	COG2850	peptidyl-arginine hydroxylation
IE977_RS09085	COG2205	protein histidine kinase activity
IE977_RS09100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IE977_RS09105	COG2915	High frequency lysogenization protein hflD homolog
IE977_RS09120	COG1187	pseudouridine synthase activity
IE977_RS09125	COG0538	isocitrate dehydrogenase activity
IE977_RS09135	COG4943	cyclic-guanylate-specific phosphodiesterase activity
IE977_RS09145	COG2261	transglycosylase associated protein
IE977_RS09160	COG2199	diguanylate cyclase activity
IE977_RS09160	COG2203	Gaf domain
IE977_RS09165	COG3042	response to heat
IE977_RS09175	COG3189	MarR family transcriptional regulator
IE977_RS09180	COG0504	CTP synthase activity
IE977_RS09185	COG2807	transmembrane transport
IE977_RS09190	COG2207	Transcriptional regulator
IE977_RS09195	COG2707	UPF0756 membrane protein
IE977_RS09205	COG2211	Major facilitator Superfamily
IE977_RS09210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IE977_RS09215	COG2718	Belongs to the UPF0229 family
IE977_RS09220	COG2766	serine protein kinase
IE977_RS09225	COG3713	MltA-interacting MipA family protein
IE977_RS09245	COG3139	Protein of unknown function (DUF1315)
IE977_RS09255	COG1335	isochorismatase
IE977_RS09260	COG0252	asparaginase activity
IE977_RS09265	COG0616	signal peptide processing
IE977_RS09270	COG0778	Nitroreductase
IE977_RS09275	COG0709	Synthesizes selenophosphate from selenide and ATP
IE977_RS09280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IE977_RS09290	COG1263	PTS System
IE977_RS09290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS09300	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
IE977_RS09325	COG0494	nUDIX hydrolase
IE977_RS09330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE977_RS09335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IE977_RS09340	COG2897	thiosulfate sulfurtransferase activity
IE977_RS09345	COG4136	ATPase activity
IE977_RS09350	COG4135	transport system, permease component
IE977_RS09355	COG4134	Bacterial extracellular solute-binding protein
IE977_RS09365	COG0708	Exodeoxyribonuclease III
IE977_RS09375	COG3138	arginine N-succinyltransferase
IE977_RS09380	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS09385	COG3724	N-succinylarginine dihydrolase activity
IE977_RS09395	COG3678	ATP-independent chaperone mediated protein folding
IE977_RS09405	COG0322	excinuclease ABC activity
IE977_RS09415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IE977_RS09420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE977_RS09425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE977_RS09430	COG1447	Phosphotransferase system cellobiose-specific component IIA
IE977_RS09435	COG2169	Transcriptional regulator
IE977_RS09435	COG1917	Cupin 2, conserved barrel domain protein
IE977_RS09440	COG1486	melibiose metabolic process
IE977_RS09445	COG3394	polysaccharide catabolic process
IE977_RS09450	COG0753	catalase activity
IE977_RS09460	COG1823	symporter activity
IE977_RS09465	COG1988	membrane-bound metal-dependent
IE977_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS09475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE977_RS09485	COG3001	Fructosamine kinase
IE977_RS09495	COG1105	Belongs to the carbohydrate kinase PfkB family
IE977_RS09500	COG3137	Salt-induced outer membrane protein
IE977_RS09545	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IE977_RS09550	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE977_RS09550	COG0072	phenylalanine-tRNA ligase activity
IE977_RS09555	COG0776	regulation of translation
IE977_RS09565	COG0386	Belongs to the glutathione peroxidase family
IE977_RS09575	COG0791	NLP P60 protein
IE977_RS09585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IE977_RS09595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE977_RS09600	COG4558	Periplasmic binding protein
IE977_RS09605	COG3720	iron ion transport
IE977_RS09615	COG4256	Hemin uptake protein
IE977_RS09620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IE977_RS09625	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IE977_RS09630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IE977_RS09630	COG0574	Belongs to the PEP-utilizing enzyme family
IE977_RS09635	COG2211	Major facilitator Superfamily
IE977_RS09640	COG1472	Belongs to the glycosyl hydrolase 3 family
IE977_RS09650	COG0628	permease
IE977_RS09655	COG0277	FAD linked oxidase domain protein
IE977_RS09655	COG0247	lactate metabolic process
IE977_RS09660	COG2050	protein possibly involved in aromatic compounds catabolism
IE977_RS09670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IE977_RS09685	COG3121	Chaperone
IE977_RS09710	COG3383	formate dehydrogenase (NAD+) activity
IE977_RS09725	COG2200	EAL domain
IE977_RS09730	COG0789	Transcriptional regulator
IE977_RS09735	COG0316	Belongs to the HesB IscA family
IE977_RS09740	COG0719	Fe-S assembly protein
IE977_RS09745	COG0396	ATPase activity
IE977_RS09750	COG0719	Fe-S assembly protein
IE977_RS09755	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IE977_RS09760	COG2166	iron-sulfur cluster assembly
IE977_RS09765	COG1376	ErfK ybiS ycfS ynhG family protein
IE977_RS09780	COG0626	cystathionine gamma-synthase activity
IE977_RS09795	COG2011	ABC-type metal ion transport system permease component
IE977_RS09800	COG1464	Belongs to the NlpA lipoprotein family
IE977_RS09810	COG0765	amino acid transport
IE977_RS09815	COG0765	amino acid transport
IE977_RS09825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE977_RS09845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE977_RS09855	COG4529	Protein conserved in bacteria
IE977_RS09870	COG0071	Belongs to the small heat shock protein (HSP20) family
IE977_RS09890	COG0307	riboflavin synthase, alpha
IE977_RS09895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IE977_RS09900	COG2814	Major facilitator Superfamily
IE977_RS09905	COG0583	DNA-binding transcription factor activity
IE977_RS09920	COG2814	Major facilitator Superfamily
IE977_RS09930	COG0791	NLP P60 protein
IE977_RS09935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IE977_RS09945	COG0346	lactoylglutathione lyase activity
IE977_RS09950	COG1902	pentaerythritol trinitrate reductase activity
IE977_RS09955	COG1309	transcriptional regulator
IE977_RS09960	COG2194	sulfuric ester hydrolase activity
IE977_RS09965	COG3313	Fe-S protein
IE977_RS09970	COG4989	oxidoreductase activity
IE977_RS09975	COG2032	superoxide dismutase activity
IE977_RS09980	COG1289	transmembrane transporter activity
IE977_RS09985	COG1566	PFAM secretion protein HlyD family protein
IE977_RS10000	COG3706	GGDEF domain
IE977_RS10010	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IE977_RS10015	COG3895	Periplasmic Protein
IE977_RS10020	COG0259	pyridoxamine-phosphate oxidase activity
IE977_RS10025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IE977_RS10030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IE977_RS10035	COG0625	glutathione transferase activity
IE977_RS10040	COG3104	oligopeptide transport
IE977_RS10045	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IE977_RS10095	COG0673	inositol 2-dehydrogenase activity
IE977_RS10100	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IE977_RS10105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IE977_RS10110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS10110	COG1263	PTS System
IE977_RS10115	COG1609	Transcriptional regulator
IE977_RS10120	COG5339	Protein conserved in bacteria
IE977_RS10130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IE977_RS10130	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IE977_RS10145	COG2205	protein histidine kinase activity
IE977_RS10155	COG1278	Cold shock
IE977_RS10165	COG0745	RESPONSE REGULATOR receiver
IE977_RS10170	COG3136	membrane protein required for alginate biosynthesis
IE977_RS10175	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS10180	COG0531	amino acid
IE977_RS10190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IE977_RS10195	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IE977_RS10200	COG0668	transmembrane transport
IE977_RS10205	COG0589	response to stress
IE977_RS10215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IE977_RS10220	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IE977_RS10225	COG1473	amidohydrolase
IE977_RS10235	COG0583	DNA-binding transcription factor activity
IE977_RS10240	COG2840	Smr protein MutS2
IE977_RS10250	COG0667	Aldo Keto reductase
IE977_RS10265	COG4993	Dehydrogenase
IE977_RS10305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IE977_RS10315	COG1403	HNH endonuclease
IE977_RS10320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE977_RS10330	COG0628	permease
IE977_RS10335	COG2076	Multidrug Resistance protein
IE977_RS10340	COG2076	Multidrug Resistance protein
IE977_RS10345	COG3591	Belongs to the peptidase S1B family
IE977_RS10355	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IE977_RS10360	COG2814	Major facilitator Superfamily
IE977_RS10365	COG0583	DNA-binding transcription factor activity
IE977_RS10370	COG1940	carbohydrate kinase activity
IE977_RS10375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IE977_RS10445	COG3141	response to X-ray
IE977_RS10450	COG3381	protein complex oligomerization
IE977_RS10455	COG3302	dmso reductase anchor subunit
IE977_RS10460	COG0437	4 iron, 4 sulfur cluster binding
IE977_RS10465	COG0243	molybdopterin cofactor binding
IE977_RS10485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE977_RS10495	COG1742	UPF0060 membrane protein
IE977_RS10500	COG4948	Mandelate Racemase Muconate Lactonizing
IE977_RS10505	COG1063	alcohol dehydrogenase
IE977_RS10510	COG0477	Major facilitator Superfamily
IE977_RS10515	COG1904	glucuronate isomerase
IE977_RS10525	COG0246	Mannitol dehydrogenase
IE977_RS10535	COG0589	response to stress
IE977_RS10540	COG1802	Transcriptional regulator
IE977_RS10545	COG4221	oxidoreductase activity
IE977_RS10560	COG4773	Receptor
IE977_RS10570	COG0725	ABC transporter, periplasmic molybdate-binding protein
IE977_RS10575	COG1176	ABC-type spermidine putrescine transport system, permease component I
IE977_RS10585	COG0814	amino acid
IE977_RS10595	COG4993	Dehydrogenase
IE977_RS10615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IE977_RS10620	COG2911	Protein conserved in bacteria
IE977_RS10630	COG3784	Protein of unknown function (DUF1318)
IE977_RS10635	COG2207	Transcriptional regulator
IE977_RS10640	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS10645	COG3706	GGDEF domain
IE977_RS10645	COG4251	negative regulation of phosphorylation
IE977_RS10645	COG5001	Diguanylate cyclase
IE977_RS10645	COG2203	Gaf domain
IE977_RS10650	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IE977_RS10655	COG3733	amine oxidase
IE977_RS10660	COG2030	dehydratase
IE977_RS10660	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS10665	COG3396	Phenylacetate-CoA oxygenase
IE977_RS10670	COG3460	Phenylacetate-CoA oxygenase
IE977_RS10675	COG3396	Phenylacetate-CoA oxygenase
IE977_RS10680	COG2151	metal-sulfur cluster biosynthetic enzyme
IE977_RS10685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IE977_RS10690	COG1024	Enoyl-CoA hydratase
IE977_RS10695	COG1024	Enoyl-CoA hydratase
IE977_RS10700	COG1250	3-hydroxyacyl-CoA dehydrogenase
IE977_RS10705	COG2050	protein possibly involved in aromatic compounds catabolism
IE977_RS10710	COG0183	Belongs to the thiolase family
IE977_RS10715	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IE977_RS10720	COG3327	negative regulation of DNA-templated transcription, initiation
IE977_RS10725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IE977_RS10755	COG0300	oxidoreductase activity
IE977_RS10770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IE977_RS10815	COG3122	Protein conserved in bacteria
IE977_RS10820	COG0564	pseudouridine synthase activity
IE977_RS10830	COG1643	Atp-dependent helicase
IE977_RS10835	COG4122	O-methyltransferase activity
IE977_RS10840	COG1538	Outer membrane efflux protein
IE977_RS10855	COG1434	Gram-negative-bacterium-type cell wall biogenesis
IE977_RS10860	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS10865	COG3038	cytochrome b561
IE977_RS10870	COG0673	inositol 2-dehydrogenase activity
IE977_RS10875	COG1349	DNA-binding transcription factor activity
IE977_RS10890	COG2274	protein secretion by the type I secretion system
IE977_RS10950	COG0840	transmembrane signaling receptor activity
IE977_RS10955	COG0583	DNA-binding transcription factor activity
IE977_RS10960	COG5383	Protein conserved in bacteria
IE977_RS10965	COG2272	Belongs to the type-B carboxylesterase lipase family
IE977_RS10975	COG0436	Aminotransferase
IE977_RS10985	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IE977_RS10990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE977_RS10995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IE977_RS11000	COG1275	C4-dicarboxylate transporter malic acid transport protein
IE977_RS11005	COG0500	methyltransferase
IE977_RS11010	COG2195	Cleaves the N-terminal amino acid of tripeptides
IE977_RS11015	COG0747	negative chemotaxis
IE977_RS11035	COG3135	benzoate transporter
IE977_RS11040	COG1396	sequence-specific DNA binding
IE977_RS11045	COG0826	peptidase U32
IE977_RS11070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IE977_RS11090	COG1129	ABC transporter
IE977_RS11100	COG3443	Belongs to the bacterial solute-binding protein 9 family
IE977_RS11105	COG2814	Major facilitator Superfamily
IE977_RS11110	COG0697	spore germination
IE977_RS11125	COG1846	Transcriptional regulator
IE977_RS11140	COG2814	Major facilitator Superfamily
IE977_RS11155	COG0583	DNA-binding transcription factor activity
IE977_RS11160	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS11170	COG2066	Belongs to the glutaminase family
IE977_RS11180	COG3706	GGDEF domain
IE977_RS11190	COG0246	Mannitol dehydrogenase
IE977_RS11195	COG3781	membrane
IE977_RS11230	COG0596	Alpha beta hydrolase
IE977_RS11255	COG0494	nUDIX hydrolase
IE977_RS11260	COG1349	DNA-binding transcription factor activity
IE977_RS11285	COG2801	Transposase and inactivated derivatives
IE977_RS11340	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IE977_RS11350	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS11355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IE977_RS11365	COG0583	DNA-binding transcription factor activity
IE977_RS11375	COG0583	DNA-binding transcription factor activity
IE977_RS11380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IE977_RS11385	COG3415	Transposase
IE977_RS11385	COG2801	Transposase and inactivated derivatives
IE977_RS11390	COG4628	conserved protein (DUF2132)
IE977_RS11395	COG1649	PFAM Uncharacterised BCR, COG1649
IE977_RS11400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IE977_RS11415	COG0840	transmembrane signaling receptor activity
IE977_RS11445	COG2200	EAL domain
IE977_RS11460	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
IE977_RS11465	COG0747	negative chemotaxis
IE977_RS11470	COG0601	transmembrane transport
IE977_RS11475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE977_RS11480	COG0444	Belongs to the ABC transporter superfamily
IE977_RS11485	COG4608	Belongs to the ABC transporter superfamily
IE977_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS11500	COG1764	response to oxidative stress
IE977_RS11530	COG0281	malic enzyme
IE977_RS11535	COG0488	(ABC) transporter
IE977_RS11540	COG1064	alcohol dehydrogenase
IE977_RS11550	COG1252	NADH dehydrogenase
IE977_RS11555	COG2814	Major facilitator Superfamily
IE977_RS11575	COG2864	formate dehydrogenase
IE977_RS11580	COG0437	4 iron, 4 sulfur cluster binding
IE977_RS11610	COG2223	nitrite transmembrane transporter activity
IE977_RS11615	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IE977_RS11620	COG1140	nitrate reductase beta subunit
IE977_RS11625	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IE977_RS11630	COG2181	nitrate reductase activity
IE977_RS11635	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IE977_RS11640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IE977_RS11650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IE977_RS11655	COG0640	Transcriptional regulator
IE977_RS11665	COG1560	Kdo2-lipid A biosynthetic process
IE977_RS11670	COG1942	4-Oxalocrotonate Tautomerase
IE977_RS11685	COG1126	abc transporter atp-binding protein
IE977_RS11700	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IE977_RS11705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE977_RS11710	COG1473	amidohydrolase
IE977_RS11715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE977_RS11745	COG4772	TonB-dependent receptor
IE977_RS11750	COG1802	Transcriptional regulator
IE977_RS11755	COG2130	NADP-dependent
IE977_RS11765	COG1247	-acetyltransferase
IE977_RS11770	COG3238	Protein conserved in bacteria
IE977_RS11780	COG0747	negative chemotaxis
IE977_RS11810	COG3615	Tellurite resistance protein tehB
IE977_RS11815	COG3615	Tellurite resistance protein tehB
IE977_RS11825	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS11830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IE977_RS11840	COG1271	oxidase subunit
IE977_RS11845	COG1294	oxidase, subunit
IE977_RS11855	COG3187	Heat shock protein
IE977_RS11860	COG3042	response to heat
IE977_RS11865	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE977_RS11865	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IE977_RS11865	COG1013	pyruvate-flavodoxin oxidoreductase activity
IE977_RS11865	COG0674	pyruvate-flavodoxin oxidoreductase activity
IE977_RS11870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IE977_RS11885	COG0582	viral genome integration into host DNA
IE977_RS11895	COG0513	Belongs to the DEAD box helicase family
IE977_RS11910	COG0840	transmembrane signaling receptor activity
IE977_RS11945	COG4166	transmembrane transport
IE977_RS11950	COG2866	Carboxypeptidase
IE977_RS11955	COG4948	Mandelate Racemase Muconate Lactonizing
IE977_RS11960	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IE977_RS11970	COG3768	UPF0283 membrane protein
IE977_RS11975	COG3106	COG3106 Predicted ATPase
IE977_RS11980	COG1609	Transcriptional regulator
IE977_RS11990	COG3842	ATPase activity
IE977_RS11995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE977_RS12000	COG1554	hydrolase, family 65, central catalytic
IE977_RS12005	COG0673	inositol 2-dehydrogenase activity
IE977_RS12010	COG1082	Xylose isomerase domain protein TIM barrel
IE977_RS12015	COG1063	alcohol dehydrogenase
IE977_RS12020	COG0395	ABC-type sugar transport system, permease component
IE977_RS12025	COG1175	transmembrane transport
IE977_RS12035	COG0366	Alpha amylase catalytic
IE977_RS12045	COG1983	PspC domain protein
IE977_RS12055	COG1842	Phage shock protein A
IE977_RS12060	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IE977_RS12075	COG4171	peptide transport system, permease
IE977_RS12085	COG4172	Belongs to the ABC transporter superfamily
IE977_RS12095	COG0251	oxidation-reduction process
IE977_RS12100	COG3708	Transcriptional regulator
IE977_RS12100	COG2207	Transcriptional regulator
IE977_RS12105	COG3706	GGDEF domain
IE977_RS12110	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IE977_RS12115	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE977_RS12115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE977_RS12120	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
IE977_RS12125	COG5001	Diguanylate cyclase
IE977_RS12130	COG1024	Enoyl-CoA hydratase
IE977_RS12140	COG1349	DNA-binding transcription factor activity
IE977_RS12150	COG0023	Translation Initiation Factor
IE977_RS12155	COG0284	orotidine-5'-phosphate decarboxylase activity
IE977_RS12160	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IE977_RS12165	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IE977_RS12170	COG0671	phosphoesterase, PA-phosphatase related
IE977_RS12180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IE977_RS12210	COG0616	signal peptide processing
IE977_RS12215	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS12220	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IE977_RS12230	COG0009	L-threonylcarbamoyladenylate synthase
IE977_RS12235	COG0613	PHP domain protein
IE977_RS12250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IE977_RS12250	COG0512	Glutamine amidotransferase of anthranilate synthase
IE977_RS12255	COG0135	phosphoribosylanthranilate isomerase activity
IE977_RS12255	COG0134	indole-3-glycerol-phosphate synthase activity
IE977_RS12260	COG0133	tryptophan synthase activity
IE977_RS12265	COG0159	tryptophan synthase activity
IE977_RS12270	COG2391	methyltransferase activity
IE977_RS12275	COG0425	Belongs to the sulfur carrier protein TusA family
IE977_RS12280	COG3047	cAMP biosynthetic process
IE977_RS12285	COG0727	PFAM Uncharacterised protein family (UPF0153)
IE977_RS12315	COG2350	Protein conserved in bacteria
IE977_RS12320	COG1280	lysine exporter protein (LysE YggA)
IE977_RS12340	COG3099	Belongs to the UPF0263 family
IE977_RS12345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IE977_RS12350	COG4608	Belongs to the ABC transporter superfamily
IE977_RS12355	COG0444	Belongs to the ABC transporter superfamily
IE977_RS12375	COG2095	MarC family integral membrane protein
IE977_RS12380	COG1454	alcohol dehydrogenase
IE977_RS12380	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS12385	COG1435	thymidine kinase activity
IE977_RS12400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IE977_RS12405	COG0745	RESPONSE REGULATOR receiver
IE977_RS12410	COG1752	Esterase of the alpha-beta hydrolase superfamily
IE977_RS12415	COG3012	SEC-C Motif Domain Protein
IE977_RS12420	COG0788	formyltetrahydrofolate deformylase activity
IE977_RS12435	COG2181	nitrate reductase activity
IE977_RS12440	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IE977_RS12445	COG1140	nitrate reductase beta subunit
IE977_RS12450	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IE977_RS12455	COG2223	nitrite transmembrane transporter activity
IE977_RS12460	COG3850	Histidine kinase
IE977_RS12465	COG2197	response regulator
IE977_RS12470	COG4932	domain protein
IE977_RS12475	COG0243	molybdopterin cofactor binding
IE977_RS12480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IE977_RS12480	COG2146	nitrite reductase [NAD(P)H] activity
IE977_RS12485	COG1116	anion transmembrane transporter activity
IE977_RS12495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IE977_RS12500	COG3707	response regulator
IE977_RS12505	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IE977_RS12510	COG0840	transmembrane signaling receptor activity
IE977_RS12520	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IE977_RS12525	COG4572	Cation transport regulator
IE977_RS12530	COG0387	Pfam Sodium calcium exchanger
IE977_RS12535	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IE977_RS12550	COG2890	protein-(glutamine-N5) methyltransferase activity
IE977_RS12560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IE977_RS12570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IE977_RS12580	COG0659	secondary active sulfate transmembrane transporter activity
IE977_RS12595	COG0193	aminoacyl-tRNA hydrolase activity
IE977_RS12600	COG0012	GTP binding
IE977_RS12630	COG3209	COG3209 Rhs family protein
IE977_RS12660	COG0515	serine threonine protein kinase
IE977_RS12785	COG4977	sequence-specific DNA binding
IE977_RS12805	COG4774	siderophore transport
IE977_RS12815	COG0741	lytic transglycosylase activity
IE977_RS12820	COG1619	proteins homologs of microcin C7 resistance protein MccF
IE977_RS12825	COG3263	regulation of cellular component size
IE977_RS12830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IE977_RS12835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE977_RS12840	COG2719	SpoVR family
IE977_RS12850	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IE977_RS12860	COG2983	Belongs to the UPF0260 family
IE977_RS12865	COG0179	Fumarylacetoacetate (FAA) hydrolase
IE977_RS12875	COG0850	regulation of cytokinetic process
IE977_RS12880	COG2894	cell division
IE977_RS12885	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IE977_RS12890	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IE977_RS12895	COG0318	PFAM AMP-dependent synthetase and ligase
IE977_RS12900	COG3065	identical protein binding
IE977_RS12905	COG1214	PFAM Peptidase M22, glycoprotease
IE977_RS12910	COG1199	ATP-dependent helicase activity
IE977_RS12915	COG0251	oxidation-reduction process
IE977_RS12930	COG0494	nUDIX hydrolase
IE977_RS12935	COG1760	l-serine dehydratase
IE977_RS12940	COG2200	EAL domain
IE977_RS12945	COG1253	flavin adenine dinucleotide binding
IE977_RS12950	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS12950	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS12955	COG3715	PTS system
IE977_RS12960	COG3716	PTS system mannose fructose sorbose family IID component
IE977_RS12965	COG4811	Protein of unknown function (DUF986)
IE977_RS12970	COG1971	Probably functions as a manganese efflux pump
IE977_RS12975	COG2226	methyltransferase
IE977_RS12980	COG0768	penicillin binding
IE977_RS13010	COG1414	Transcriptional regulator
IE977_RS13015	COG2814	Major facilitator Superfamily
IE977_RS13020	COG0501	Belongs to the peptidase M48B family
IE977_RS13030	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IE977_RS13035	COG1956	GAF domain-containing protein
IE977_RS13040	COG2995	paraquat-inducible protein a
IE977_RS13045	COG3008	intermembrane lipid transfer
IE977_RS13050	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IE977_RS13050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IE977_RS13065	COG2990	Protein conserved in bacteria
IE977_RS13080	COG1276	copper resistance
IE977_RS13085	COG2372	response to copper ion
IE977_RS13095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IE977_RS13100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IE977_RS13105	COG1770	oligopeptidase
IE977_RS13110	COG2979	Protein of unknown function (DUF533)
IE977_RS13120	COG0800	Aldolase
IE977_RS13125	COG0129	dihydroxy-acid dehydratase activity
IE977_RS13130	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IE977_RS13135	COG1737	Transcriptional regulator
IE977_RS13145	COG1560	Kdo2-lipid A biosynthetic process
IE977_RS13150	COG0739	heme binding
IE977_RS13155	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
IE977_RS13165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE977_RS13170	COG2255	four-way junction helicase activity
IE977_RS13175	COG0632	four-way junction helicase activity
IE977_RS13190	COG0494	nUDIX hydrolase
IE977_RS13200	COG1335	isochorismatase
IE977_RS13380	COG0484	heat shock protein binding
IE977_RS13385	COG0305	Participates in initiation and elongation during chromosome replication
IE977_RS13390	COG1484	DNA-dependent DNA replication
IE977_RS13475	COG1801	Protein of unknown function DUF72
IE977_RS13480	COG3788	relative of glutathione S-transferase, MAPEG superfamily
IE977_RS13485	COG2226	methyltransferase
IE977_RS13490	COG0500	methyltransferase
IE977_RS13495	COG3142	Participates in the control of copper homeostasis
IE977_RS13500	COG3102	Protein conserved in bacteria
IE977_RS13505	COG0018	arginyl-trna synthetase
IE977_RS13510	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IE977_RS13540	COG0745	RESPONSE REGULATOR receiver
IE977_RS13555	COG0840	transmembrane signaling receptor activity
IE977_RS13590	COG1301	dicarboxylic acid transport
IE977_RS13630	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IE977_RS13640	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS13650	COG1879	ABC-type sugar transport system periplasmic component
IE977_RS13660	COG1528	Iron-storage protein
IE977_RS13665	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IE977_RS13695	COG1528	Iron-storage protein
IE977_RS13705	COG0814	amino acid
IE977_RS13710	COG3318	Belongs to the UPF0149 family
IE977_RS13710	COG3012	SEC-C Motif Domain Protein
IE977_RS13745	COG0583	DNA-binding transcription factor activity
IE977_RS13765	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IE977_RS13770	COG3012	SEC-C Motif Domain Protein
IE977_RS13770	COG3318	Belongs to the UPF0149 family
IE977_RS13775	COG0732	type I restriction modification DNA specificity domain
IE977_RS13820	COG3596	GTP binding
IE977_RS13855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IE977_RS13860	COG2826	transposase and inactivated derivatives, IS30 family
IE977_RS13895	COG2197	response regulator
IE977_RS13905	COG2197	response regulator
IE977_RS13910	COG1126	abc transporter atp-binding protein
IE977_RS13915	COG0765	amino acid transport
IE977_RS13925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE977_RS13940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IE977_RS13945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IE977_RS13950	COG1516	flagellar protein fliS
IE977_RS13960	COG0366	Alpha amylase catalytic
IE977_RS13980	COG2246	polysaccharide biosynthetic process
IE977_RS14100	COG5410	chromosome segregation
IE977_RS14220	COG3756	Protein conserved in bacteria
IE977_RS14245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IE977_RS14300	COG0270	DNA (cytosine-5-)-methyltransferase activity
IE977_RS14350	COG0582	viral genome integration into host DNA
IE977_RS14355	COG1677	Flagellar hook-basal body complex protein FliE
IE977_RS14365	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IE977_RS14375	COG1157	protein secretion by the type III secretion system
IE977_RS14415	COG1987	bacterial-type flagellum assembly
IE977_RS14425	COG2197	response regulator
IE977_RS14450	COG5475	Uncharacterized small protein (DUF2158)
IE977_RS14455	COG2354	Protein conserved in bacteria
IE977_RS14460	COG0697	spore germination
IE977_RS14465	COG3727	T/G mismatch-specific endonuclease activity
IE977_RS14470	COG0270	DNA (cytosine-5-)-methyltransferase activity
IE977_RS14475	COG1418	mRNA catabolic process
IE977_RS14480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IE977_RS14490	COG3290	protein histidine kinase activity
IE977_RS14495	COG4565	transcriptional regulatory protein
IE977_RS14515	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IE977_RS14515	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IE977_RS14540	COG0583	DNA-binding transcription factor activity
IE977_RS14595	COG0737	Belongs to the 5'-nucleotidase family
IE977_RS14600	COG0737	Belongs to the 5'-nucleotidase family
IE977_RS14605	COG3248	Nucleoside-binding outer membrane protein
IE977_RS14625	COG1376	ErfK ybiS ycfS ynhG family protein
IE977_RS14630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IE977_RS14635	COG0589	response to stress
IE977_RS14645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE977_RS14660	COG0477	Major facilitator Superfamily
IE977_RS14665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IE977_RS14675	COG0534	Mate efflux family protein
IE977_RS14690	COG1289	transmembrane transporter activity
IE977_RS14695	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IE977_RS14705	COG2925	Exonuclease
IE977_RS14710	COG0531	amino acid
IE977_RS14720	COG0583	DNA-binding transcription factor activity
IE977_RS14725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IE977_RS14735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IE977_RS14745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IE977_RS14750	COG0131	Imidazoleglycerol-phosphate dehydratase
IE977_RS14750	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IE977_RS14755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IE977_RS14760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IE977_RS14765	COG0107	imidazoleglycerol-phosphate synthase activity
IE977_RS14800	COG1091	dTDP-4-dehydrorhamnose reductase activity
IE977_RS14825	COG0438	transferase activity, transferring glycosyl groups
IE977_RS14840	COG0438	transferase activity, transferring glycosyl groups
IE977_RS14845	COG0438	transferase activity, transferring glycosyl groups
IE977_RS14875	COG0438	transferase activity, transferring glycosyl groups
IE977_RS14880	COG2327	Polysaccharide pyruvyl transferase
IE977_RS14885	COG2244	polysaccharide biosynthetic process
IE977_RS14890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IE977_RS14895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IE977_RS14905	COG0297	glycogen (starch) synthase activity
IE977_RS14910	COG1051	belongs to the nudix hydrolase family
IE977_RS14915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IE977_RS14920	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IE977_RS14925	COG0110	maltose O-acetyltransferase activity
IE977_RS14930	COG1216	Glycosyl transferase, family 2
IE977_RS14940	COG0438	transferase activity, transferring glycosyl groups
IE977_RS14945	COG1045	serine acetyltransferase
IE977_RS14950	COG0463	Glycosyl transferase, family 2
IE977_RS14955	COG3206	protein involved in exopolysaccharide biosynthesis
IE977_RS14955	COG0489	protein tyrosine kinase activity
IE977_RS14970	COG1253	flavin adenine dinucleotide binding
IE977_RS14975	COG2982	Protein involved in outer membrane biogenesis
IE977_RS14980	COG0717	Belongs to the dCTP deaminase family
IE977_RS14990	COG3447	MASE1 domain protein
IE977_RS14990	COG5002	protein histidine kinase activity
IE977_RS14990	COG5001	Diguanylate cyclase
IE977_RS14995	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IE977_RS15000	COG0443	Heat shock 70 kDa protein
IE977_RS15010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE977_RS15015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE977_RS15020	COG0477	Major facilitator Superfamily
IE977_RS15025	COG2205	protein histidine kinase activity
IE977_RS15030	COG0745	RESPONSE REGULATOR receiver
IE977_RS15035	COG2801	Transposase and inactivated derivatives
IE977_RS15035	COG3415	Transposase
IE977_RS15040	COG0826	peptidase U32
IE977_RS15045	COG1597	lipid kinase activity
IE977_RS15050	COG4608	Belongs to the ABC transporter superfamily
IE977_RS15055	COG0444	Belongs to the ABC transporter superfamily
IE977_RS15060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IE977_RS15065	COG0601	transmembrane transport
IE977_RS15070	COG0747	negative chemotaxis
IE977_RS15075	COG4948	Mandelate Racemase Muconate Lactonizing
IE977_RS15080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE977_RS15090	COG1070	Carbohydrate kinase
IE977_RS15115	COG1070	Carbohydrate kinase
IE977_RS15125	COG1830	Aldolase
IE977_RS15130	COG2211	Major facilitator Superfamily
IE977_RS15135	COG1397	ADP-ribosylglycohydrolase
IE977_RS15140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE977_RS15145	COG2188	Transcriptional regulator
IE977_RS15150	COG0351	phosphomethylpyrimidine kinase
IE977_RS15155	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IE977_RS15245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IE977_RS15250	COG0076	glutamate decarboxylase activity
IE977_RS15255	COG0489	protein tyrosine kinase activity
IE977_RS15255	COG3206	protein involved in exopolysaccharide biosynthesis
IE977_RS15260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IE977_RS15265	COG1596	polysaccharide export
IE977_RS15270	COG5455	response to cobalt ion
IE977_RS15280	COG0489	protein tyrosine kinase activity
IE977_RS15290	COG4807	Protein conserved in bacteria
IE977_RS15300	COG3275	phosphorelay sensor kinase activity
IE977_RS15305	COG0789	Transcriptional regulator
IE977_RS15315	COG1174	glycine betaine transport
IE977_RS15320	COG1125	glycine betaine transport
IE977_RS15325	COG1174	glycine betaine transport
IE977_RS15330	COG1732	Glycine betaine
IE977_RS15335	COG1472	Belongs to the glycosyl hydrolase 3 family
IE977_RS15340	COG0277	FAD linked oxidase domain protein
IE977_RS15350	COG1686	Belongs to the peptidase S11 family
IE977_RS15360	COG0586	Pfam SNARE associated Golgi protein
IE977_RS15365	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS15370	COG1538	Outer membrane efflux protein
IE977_RS15375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IE977_RS15385	COG1346	cytolysis
IE977_RS15390	COG0295	cytidine deaminase activity
IE977_RS15395	COG2949	membrane
IE977_RS15405	COG1129	ABC transporter
IE977_RS15420	COG2311	Membrane
IE977_RS15430	COG0477	Major facilitator Superfamily
IE977_RS15435	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IE977_RS15440	COG4771	TonB-dependent receptor
IE977_RS15445	COG0833	amino acid
IE977_RS15450	COG0583	DNA-binding transcription factor activity
IE977_RS15455	COG2855	membrane
IE977_RS15460	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IE977_RS15465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE977_RS15465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IE977_RS15465	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
IE977_RS15470	COG1105	Belongs to the carbohydrate kinase PfkB family
IE977_RS15475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS15475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS15495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IE977_RS15500	COG1312	Catalyzes the dehydration of D-mannonate
IE977_RS15505	COG0246	Mannitol dehydrogenase
IE977_RS15510	COG0523	cobalamin synthesis protein
IE977_RS15515	COG0671	phosphoesterase, PA-phosphatase related
IE977_RS15520	COG0791	NLP P60 protein
IE977_RS15525	COG2200	EAL domain
IE977_RS15530	COG4166	transmembrane transport
IE977_RS15535	COG4174	ABC transporter (Permease)
IE977_RS15540	COG4239	(ABC) transporter, permease
IE977_RS15545	COG4172	Belongs to the ABC transporter superfamily
IE977_RS15555	COG2814	Major facilitator Superfamily
IE977_RS15560	COG1187	pseudouridine synthase activity
IE977_RS15565	COG1061	Type III restriction enzyme res subunit
IE977_RS15575	COG3081	Nucleoid-associated protein
IE977_RS15580	COG3082	Protein of unknown function (DUF1414)
IE977_RS15595	COG3182	Iron-regulated membrane protein
IE977_RS15605	COG0579	oxidoreductase
IE977_RS15610	COG0659	secondary active sulfate transmembrane transporter activity
IE977_RS15615	COG2239	Acts as a magnesium transporter
IE977_RS15620	COG4615	Cyclic peptide transporter
IE977_RS15630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IE977_RS15630	COG2169	Transcriptional regulator
IE977_RS15640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
IE977_RS15645	COG2198	Histidine kinase
IE977_RS15645	COG0642	Histidine kinase
IE977_RS15665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IE977_RS15680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IE977_RS15685	COG0584	glycerophosphoryl diester phosphodiesterase
IE977_RS15690	COG2271	Major facilitator Superfamily
IE977_RS15695	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IE977_RS15700	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
IE977_RS15705	COG0247	lactate metabolic process
IE977_RS15750	COG1441	menaquinone biosynthetic process
IE977_RS15760	COG0596	Alpha beta hydrolase
IE977_RS15765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IE977_RS15770	COG1169	isochorismate synthase
IE977_RS15775	COG4575	ribosome binding
IE977_RS15780	COG2153	protein acetylation
IE977_RS15785	COG1234	tRNA 3'-trailer cleavage
IE977_RS15790	COG0784	Response regulator, receiver
IE977_RS15790	COG0835	chemotaxis
IE977_RS15795	COG1007	ATP synthesis coupled electron transport
IE977_RS15800	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE977_RS15805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IE977_RS15810	COG0713	ATP synthesis coupled electron transport
IE977_RS15815	COG0839	Belongs to the complex I subunit 6 family
IE977_RS15825	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IE977_RS15855	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE977_RS15860	COG0583	DNA-binding transcription factor activity
IE977_RS15865	COG0436	Aminotransferase
IE977_RS15875	COG0490	domain, Protein
IE977_RS15875	COG0471	metal ion transport
IE977_RS15880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE977_RS15905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IE977_RS15910	COG3959	Transketolase, thiamine diphosphate binding domain
IE977_RS15915	COG3037	sugar-specific permease SgaT UlaA
IE977_RS15925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS15930	COG1609	Transcriptional regulator
IE977_RS15940	COG0622	Phosphoesterase
IE977_RS15945	COG0625	glutathione transferase activity
IE977_RS15950	COG0625	glutathione transferase activity
IE977_RS15955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IE977_RS15960	COG1090	epimerase
IE977_RS15965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE977_RS15970	COG4598	ABC transporter
IE977_RS15975	COG4160	amino acid transport
IE977_RS15985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE977_RS15995	COG0163	prenyltransferase activity
IE977_RS16000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IE977_RS16005	COG1286	toxin biosynthetic process
IE977_RS16010	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IE977_RS16015	COG0285	dihydrofolate synthase activity
IE977_RS16025	COG0586	Pfam SNARE associated Golgi protein
IE977_RS16030	COG0101	tRNA pseudouridine synthase activity
IE977_RS16035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IE977_RS16040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IE977_RS16055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE977_RS16060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IE977_RS16060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IE977_RS16070	COG3101	peptidyl-lysine hydroxylation
IE977_RS16075	COG0730	response to heat
IE977_RS16085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IE977_RS16095	COG2840	Smr protein MutS2
IE977_RS16100	COG2062	phosphohistidine phosphatase, SixA
IE977_RS16105	COG1024	Enoyl-CoA hydratase
IE977_RS16105	COG1250	3-hydroxyacyl-CoA dehydrogenase
IE977_RS16115	COG3691	Protein conserved in bacteria
IE977_RS16120	COG2067	long-chain fatty acid transport protein
IE977_RS16130	COG2116	formate transmembrane transporter activity
IE977_RS16140	COG3706	GGDEF domain
IE977_RS16145	COG1560	Kdo2-lipid A biosynthetic process
IE977_RS16155	COG0436	Aminotransferase
IE977_RS16160	COG3275	phosphorelay sensor kinase activity
IE977_RS16165	COG3279	Response regulator of the LytR AlgR family
IE977_RS16170	COG0837	glucose binding
IE977_RS16180	COG3961	Belongs to the TPP enzyme family
IE977_RS16185	COG0667	Aldo Keto reductase
IE977_RS16195	COG1914	H( )-stimulated, divalent metal cation uptake system
IE977_RS16200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IE977_RS16205	COG2200	EAL domain
IE977_RS16205	COG2199	diguanylate cyclase activity
IE977_RS16220	COG3415	Transposase
IE977_RS16225	COG3415	Transposase
IE977_RS16230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IE977_RS16260	COG0583	DNA-binding transcription factor activity
IE977_RS16265	COG0385	Bile acid
IE977_RS16270	COG3530	Putative quorum-sensing-regulated virulence factor
IE977_RS16275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IE977_RS16280	COG3115	cell septum assembly
IE977_RS16295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS16320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IE977_RS16325	COG4208	sulfate ABC transporter
IE977_RS16330	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IE977_RS16335	COG4150	thiosulfate binding
IE977_RS16340	COG2837	iron assimilation
IE977_RS16365	COG0408	coproporphyrinogen oxidase activity
IE977_RS16380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IE977_RS16385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IE977_RS16390	COG1609	Transcriptional regulator
IE977_RS16395	COG3250	beta-galactosidase activity
IE977_RS16400	COG2731	YhcH YjgK YiaL family protein
IE977_RS16405	COG0531	amino acid
IE977_RS16415	COG3408	Glycogen debranching enzyme
IE977_RS16415	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IE977_RS16420	COG5342	invasion associated locus B
IE977_RS16425	COG0494	nUDIX hydrolase
IE977_RS16430	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE977_RS16430	COG0493	'glutamate synthase
IE977_RS16435	COG3850	Histidine kinase
IE977_RS16440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE977_RS16450	COG1393	Belongs to the ArsC family
IE977_RS16455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IE977_RS16465	COG0400	carboxylic ester hydrolase activity
IE977_RS16475	COG2321	neutral zinc metallopeptidase
IE977_RS16480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IE977_RS16485	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IE977_RS16495	COG2716	regulation of RNA biosynthetic process
IE977_RS16500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IE977_RS16505	COG0628	permease
IE977_RS16510	COG4783	chaperone-mediated protein folding
IE977_RS16515	COG1393	Belongs to the ArsC family
IE977_RS16530	COG1446	asparaginase
IE977_RS16535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IE977_RS16545	COG2233	PERMEase
IE977_RS16550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IE977_RS16555	COG2723	6-phospho-beta-galactosidase activity
IE977_RS16565	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IE977_RS16580	COG2200	EAL domain
IE977_RS16600	COG3713	MltA-interacting MipA family protein
IE977_RS16605	COG0745	RESPONSE REGULATOR receiver
IE977_RS16625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE977_RS16650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE977_RS16660	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IE977_RS16680	COG5314	conjugation
IE977_RS16710	COG0582	viral genome integration into host DNA
IE977_RS16720	COG0517	IMP dehydrogenase activity
IE977_RS16720	COG0516	GMP reductase activity
IE977_RS16725	COG1570	exodeoxyribonuclease VII activity
IE977_RS16740	COG1645	bacterial-type flagellum-dependent swarming motility
IE977_RS16755	COG1160	GTP binding
IE977_RS16765	COG2976	Protein conserved in bacteria
IE977_RS16770	COG0124	histidyl-tRNA synthetase
IE977_RS16785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IE977_RS16805	COG0437	4 iron, 4 sulfur cluster binding
IE977_RS16810	COG0243	molybdopterin cofactor binding
IE977_RS16815	COG4953	penicillin-binding protein 1C
IE977_RS16820	COG2373	Large extracellular alpha-helical protein
IE977_RS16825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS16825	COG1263	PTS System
IE977_RS16825	COG2190	(PTS) system
IE977_RS16835	COG2897	thiosulfate sulfurtransferase activity
IE977_RS16840	COG1737	Transcriptional regulator
IE977_RS16850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IE977_RS16855	COG2975	iron-sulfur cluster assembly
IE977_RS16860	COG0633	Ferredoxin
IE977_RS16865	COG0443	Heat shock 70 kDa protein
IE977_RS16870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IE977_RS16875	COG0316	Belongs to the HesB IscA family
IE977_RS16880	COG0822	iron-sulfur transferase activity
IE977_RS16885	COG1104	cysteine desulfurase activity
IE977_RS16890	COG1959	2 iron, 2 sulfur cluster binding
IE977_RS16905	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IE977_RS16915	COG3711	transcriptional antiterminator
IE977_RS16920	COG2814	Major facilitator Superfamily
IE977_RS16925	COG2259	Doxx family
IE977_RS16935	COG1017	nitric oxide dioxygenase activity
IE977_RS16935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IE977_RS16940	COG0347	Belongs to the P(II) protein family
IE977_RS16945	COG2204	response regulator
IE977_RS16950	COG3170	Tfp pilus assembly protein FimV
IE977_RS16955	COG2205	protein histidine kinase activity
IE977_RS16960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IE977_RS16960	COG0047	phosphoribosylformylglycinamidine synthase activity
IE977_RS16965	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IE977_RS16975	COG0560	Phosphoserine phosphatase
IE977_RS16980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS16980	COG1263	PTS System
IE977_RS16985	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IE977_RS16990	COG1737	Transcriptional regulator
IE977_RS16995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE977_RS17005	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IE977_RS17010	COG1381	Involved in DNA repair and RecF pathway recombination
IE977_RS17025	COG0681	Belongs to the peptidase S26 family
IE977_RS17035	COG3086	response to oxidative stress
IE977_RS17045	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
IE977_RS17055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IE977_RS17060	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IE977_RS17065	COG0513	Belongs to the DEAD box helicase family
IE977_RS17070	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
IE977_RS17075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IE977_RS17080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IE977_RS17085	COG3118	belongs to the thioredoxin family
IE977_RS17090	COG3148	PFAM DTW domain containing protein
IE977_RS17095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE977_RS17095	COG0045	succinate-CoA ligase (ADP-forming) activity
IE977_RS17095	COG1042	CoA-binding domain protein
IE977_RS17100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IE977_RS17105	COG5544	Lipoprotein
IE977_RS17110	COG0477	Major facilitator Superfamily
IE977_RS17140	COG0542	response to heat
IE977_RS17150	COG0564	pseudouridine synthase activity
IE977_RS17155	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IE977_RS17160	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IE977_RS17170	COG0077	Prephenate dehydratase
IE977_RS17170	COG1605	Chorismate mutase
IE977_RS17180	COG1605	Chorismate mutase
IE977_RS17180	COG0287	Prephenate dehydrogenase
IE977_RS17185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IE977_RS17200	COG2199	diguanylate cyclase activity
IE977_RS17205	COG2885	chlorophyll binding
IE977_RS17225	COG0336	Belongs to the RNA methyltransferase TrmD family
IE977_RS17230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IE977_RS17240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IE977_RS17245	COG4137	Cytochrome C assembly protein
IE977_RS17250	COG4536	flavin adenine dinucleotide binding
IE977_RS17255	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IE977_RS17260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IE977_RS17265	COG0497	DNA recombination
IE977_RS17280	COG2867	negative regulation of translational initiation
IE977_RS17295	COG0582	viral genome integration into host DNA
IE977_RS17305	COG1475	DNA binding
IE977_RS17325	COG3409	Peptidoglycan-binding domain 1 protein
IE977_RS17325	COG3429	Glucose-6-phosphate dehydrogenase subunit
IE977_RS17375	COG2814	Major facilitator Superfamily
IE977_RS17380	COG1846	Transcriptional regulator
IE977_RS17385	COG1566	PFAM secretion protein HlyD family protein
IE977_RS17390	COG2814	Major facilitator Superfamily
IE977_RS17395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IE977_RS17410	COG2918	glutathione biosynthetic process
IE977_RS17415	COG1238	metal cluster binding
IE977_RS17420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE977_RS17450	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IE977_RS17455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IE977_RS17470	COG1546	Belongs to the CinA family
IE977_RS17480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IE977_RS17490	COG2951	lytic endotransglycosylase activity
IE977_RS17495	COG3730	PTS system glucitol sorbitol-specific
IE977_RS17500	COG3732	PTS system glucitol sorbitol-specific
IE977_RS17510	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS17515	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS17520	COG1349	DNA-binding transcription factor activity
IE977_RS17530	COG3604	Transcriptional regulator
IE977_RS17535	COG1773	rubredoxin
IE977_RS17535	COG0426	domain, Protein
IE977_RS17540	COG0446	pyridine nucleotide-disulphide oxidoreductase
IE977_RS17545	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IE977_RS17550	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IE977_RS17555	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE977_RS17560	COG1609	Transcriptional regulator
IE977_RS17565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS17565	COG1263	PTS System
IE977_RS17570	COG2723	6-phospho-beta-galactosidase activity
IE977_RS17575	COG3415	Transposase
IE977_RS17575	COG2801	Transposase and inactivated derivatives
IE977_RS17580	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IE977_RS17590	COG3260	NADH ubiquinone oxidoreductase 20
IE977_RS17595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IE977_RS17600	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
IE977_RS17600	COG3261	NADH dehydrogenase
IE977_RS17605	COG0650	Formate hydrogenlyase subunit 4
IE977_RS17610	COG0651	ATP synthesis coupled electron transport
IE977_RS17615	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE977_RS17625	COG0375	protein maturation
IE977_RS17630	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IE977_RS17635	COG0298	carbon dioxide binding
IE977_RS17640	COG0409	Hydrogenase expression formation protein
IE977_RS17645	COG0309	Hydrogenase expression formation protein (HypE)
IE977_RS17665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IE977_RS17675	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IE977_RS17680	COG0163	prenyltransferase activity
IE977_RS17695	COG0477	Major facilitator Superfamily
IE977_RS17710	COG4942	peptidase
IE977_RS17710	COG1388	LysM domain
IE977_RS17725	COG0585	pseudouridine synthase activity
IE977_RS17735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IE977_RS17740	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IE977_RS17750	COG0529	Catalyzes the synthesis of activated sulfate
IE977_RS17770	COG2234	aminopeptidase activity
IE977_RS17785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IE977_RS17790	COG0720	synthase
IE977_RS17800	COG1473	amidohydrolase
IE977_RS17810	COG0602	queuosine metabolic process
IE977_RS17815	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IE977_RS17820	COG2190	(PTS) system
IE977_RS17820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS17820	COG1263	PTS System
IE977_RS17825	COG1737	Transcriptional regulator
IE977_RS17840	COG3956	TIGRFAM MazG family protein
IE977_RS17845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IE977_RS17850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IE977_RS17855	COG2205	protein histidine kinase activity
IE977_RS17855	COG3437	response regulator, receiver
IE977_RS17855	COG3850	Histidine kinase
IE977_RS17855	COG4999	Histidine kinase
IE977_RS17860	COG1929	Belongs to the glycerate kinase type-1 family
IE977_RS17865	COG4948	Mandelate Racemase Muconate Lactonizing
IE977_RS17870	COG4948	Mandelate Racemase Muconate Lactonizing
IE977_RS17875	COG2271	Major facilitator Superfamily
IE977_RS17880	COG0716	FMN binding
IE977_RS17885	COG0564	pseudouridine synthase activity
IE977_RS17890	COG3098	single-species biofilm formation
IE977_RS17905	COG1611	Belongs to the LOG family
IE977_RS17910	COG0814	amino acid
IE977_RS17915	COG1760	l-serine dehydratase
IE977_RS17925	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
IE977_RS17930	COG2363	Small membrane protein
IE977_RS17935	COG0583	DNA-binding transcription factor activity
IE977_RS17945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IE977_RS17950	COG2166	iron-sulfur cluster assembly
IE977_RS17955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IE977_RS17960	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IE977_RS17980	COG0860	N-Acetylmuramoyl-L-alanine amidase
IE977_RS17985	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IE977_RS17985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IE977_RS17990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IE977_RS17995	COG1074	ATP-dependent DNA helicase activity
IE977_RS18005	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IE977_RS18010	COG4967	type IV pilus modification protein PilV
IE977_RS18020	COG4795	General secretion pathway protein
IE977_RS18025	COG2165	general secretion pathway protein
IE977_RS18030	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IE977_RS18035	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IE977_RS18045	COG0494	nUDIX hydrolase
IE977_RS18050	COG3066	DNA modification
IE977_RS18060	COG0667	Aldo Keto reductase
IE977_RS18065	COG0477	Major facilitator Superfamily
IE977_RS18070	COG0318	PFAM AMP-dependent synthetase and ligase
IE977_RS18070	COG0204	Acyl-transferase
IE977_RS18075	COG1609	Transcriptional regulator
IE977_RS18085	COG2186	Transcriptional regulator
IE977_RS18090	COG2723	6-phospho-beta-galactosidase activity
IE977_RS18095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IE977_RS18100	COG1609	Transcriptional regulator
IE977_RS18110	COG0583	DNA-binding transcription factor activity
IE977_RS18115	COG1794	racemase activity, acting on amino acids and derivatives
IE977_RS18125	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
IE977_RS18130	COG1175	transmembrane transport
IE977_RS18135	COG0395	ABC-type sugar transport system, permease component
IE977_RS18140	COG3842	ATPase activity
IE977_RS18150	COG2814	Major facilitator Superfamily
IE977_RS18155	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS18160	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IE977_RS18165	COG0823	Involved in the tonB-independent uptake of proteins
IE977_RS18170	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IE977_RS18175	COG0183	Belongs to the thiolase family
IE977_RS18190	COG0814	amino acid
IE977_RS18195	COG2388	GCN5-related N-acetyl-transferase
IE977_RS18200	COG3592	Divergent 4Fe-4S mono-cluster
IE977_RS18205	COG3729	General stress protein
IE977_RS18210	COG3685	Protein conserved in bacteria
IE977_RS18215	COG3685	Protein conserved in bacteria
IE977_RS18220	COG3546	catalase activity
IE977_RS18225	COG1271	oxidase subunit
IE977_RS18230	COG1294	oxidase, subunit
IE977_RS18245	COG1546	Belongs to the CinA family
IE977_RS18260	COG3111	PFAM Bacterial OB fold (BOF) protein
IE977_RS18265	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS18270	COG2015	COG2015, Alkyl sulfatase and related hydrolases
IE977_RS18290	COG2067	long-chain fatty acid transport protein
IE977_RS18335	COG2801	Transposase and inactivated derivatives
IE977_RS18410	COG4942	peptidase
IE977_RS18415	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IE977_RS18420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IE977_RS18430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IE977_RS18440	COG4974	Belongs to the 'phage' integrase family
IE977_RS18455	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IE977_RS18460	COG0354	folic acid binding
IE977_RS18465	COG1272	protein, Hemolysin III
IE977_RS18470	COG1737	Transcriptional regulator
IE977_RS18475	COG2723	6-phospho-beta-galactosidase activity
IE977_RS18495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IE977_RS18500	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS18505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IE977_RS18505	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IE977_RS18515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IE977_RS18520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IE977_RS18525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IE977_RS18530	COG0006	proline dipeptidase activity
IE977_RS18540	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IE977_RS18550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IE977_RS18555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IE977_RS18560	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IE977_RS18565	COG0583	DNA-binding transcription factor activity
IE977_RS18570	COG2968	Membrane
IE977_RS18575	COG1279	arginine transmembrane transporter activity
IE977_RS18580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IE977_RS18585	COG0668	transmembrane transport
IE977_RS18590	COG0191	fructose-bisphosphate aldolase activity
IE977_RS18595	COG0126	phosphoglycerate kinase activity
IE977_RS18600	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IE977_RS18605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IE977_RS18610	COG0501	Belongs to the peptidase M48B family
IE977_RS18630	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
IE977_RS18635	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS18640	COG2267	carboxylic ester hydrolase activity
IE977_RS18665	COG1414	Transcriptional regulator
IE977_RS18670	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS18685	COG2146	nitrite reductase [NAD(P)H] activity
IE977_RS18695	COG0010	Belongs to the arginase family
IE977_RS18700	COG1166	arginine decarboxylase activity
IE977_RS18720	COG2814	Major facilitator Superfamily
IE977_RS18725	COG3091	SprT-like family
IE977_RS18730	COG2356	endonuclease I
IE977_RS18735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IE977_RS18755	COG2805	Type II/IV secretion system protein
IE977_RS18760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IE977_RS18765	COG0762	integral membrane protein
IE977_RS18770	COG1872	DUF167
IE977_RS18780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IE977_RS18785	COG2852	Protein conserved in bacteria
IE977_RS18795	COG3171	Protein conserved in bacteria
IE977_RS18805	COG1194	a g-specific adenine glycosylase
IE977_RS18815	COG0741	lytic transglycosylase activity
IE977_RS18820	COG2211	Major facilitator Superfamily
IE977_RS18825	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IE977_RS18845	COG3052	prosthetic group binding
IE977_RS18855	COG0179	Fumarylacetoacetate (FAA) hydrolase
IE977_RS18860	COG3493	citrate carrier protein
IE977_RS18875	COG1982	Orn Lys Arg decarboxylase major
IE977_RS18880	COG1811	Na channel or pump
IE977_RS18890	COG2205	protein histidine kinase activity
IE977_RS18890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IE977_RS18895	COG2197	response regulator
IE977_RS18915	COG0457	Tetratricopeptide repeat
IE977_RS18920	COG1649	PFAM Uncharacterised BCR, COG1649
IE977_RS18920	COG0726	polysaccharide deacetylase
IE977_RS18925	COG1215	transferase activity, transferring glycosyl groups
IE977_RS18935	COG0754	glutathionylspermidine amidase activity
IE977_RS18940	COG0625	glutathione transferase activity
IE977_RS18945	COG1349	DNA-binding transcription factor activity
IE977_RS18950	COG0840	transmembrane signaling receptor activity
IE977_RS18955	COG0667	Aldo Keto reductase
IE977_RS18960	COG2862	Uncharacterized protein family, UPF0114
IE977_RS18980	COG0848	biopolymer transport protein
IE977_RS18990	COG0626	cystathionine gamma-synthase activity
IE977_RS18995	COG0586	Pfam SNARE associated Golgi protein
IE977_RS19000	COG2207	Transcriptional regulator
IE977_RS19005	COG1979	alcohol dehydrogenase
IE977_RS19085	COG3436	PFAM IS66 Orf2 family protein
IE977_RS19105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IE977_RS19115	COG1595	DNA-templated transcription, initiation
IE977_RS19120	COG3712	iron ion homeostasis
IE977_RS19125	COG4772	TonB-dependent receptor
IE977_RS19130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IE977_RS19135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE977_RS19140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE977_RS19145	COG1120	ATPase activity
IE977_RS19150	COG3436	PFAM IS66 Orf2 family protein
IE977_RS19170	COG1609	Transcriptional regulator
IE977_RS19180	COG2223	nitrite transmembrane transporter activity
IE977_RS19220	COG3436	PFAM IS66 Orf2 family protein
IE977_RS19225	COG4372	Transposase
IE977_RS19260	COG3415	Transposase
IE977_RS19260	COG2801	Transposase and inactivated derivatives
IE977_RS19280	COG3111	PFAM Bacterial OB fold (BOF) protein
IE977_RS19295	COG2249	NAD(P)H dehydrogenase (quinone) activity
IE977_RS19300	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IE977_RS19305	COG1652	LysM domain
IE977_RS19310	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IE977_RS19315	COG2211	Major facilitator Superfamily
IE977_RS19340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE977_RS19345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IE977_RS19350	COG1120	ATPase activity
IE977_RS19355	COG4774	siderophore transport
IE977_RS19360	COG0187	DNA topoisomerase II activity
IE977_RS19365	COG3150	esterase
IE977_RS19370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IE977_RS19375	COG3151	Protein conserved in bacteria
IE977_RS19380	COG0494	nUDIX hydrolase
IE977_RS19395	COG0754	glutathionylspermidine amidase activity
IE977_RS19400	COG3384	dioxygenase
IE977_RS19410	COG3335	DDE superfamily endonuclease
IE977_RS19415	COG3539	Fimbrial protein
IE977_RS19425	COG3121	Chaperone
IE977_RS19430	COG3539	Fimbrial protein
IE977_RS19435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IE977_RS19445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IE977_RS19445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IE977_RS19455	COG3025	triphosphatase activity
IE977_RS19460	COG4991	sh3 domain protein
IE977_RS19465	COG0617	tRNA 3'-terminal CCA addition
IE977_RS19475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IE977_RS19485	COG0477	Major facilitator Superfamily
IE977_RS19490	COG0829	nickel cation binding
IE977_RS19495	COG0831	urea catabolic process
IE977_RS19500	COG0832	Belongs to the urease beta subunit family
IE977_RS19505	COG0804	urea catabolic process
IE977_RS19510	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IE977_RS19520	COG0830	nickel cation binding
IE977_RS19525	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IE977_RS19535	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IE977_RS19540	COG0358	DNA primase activity
IE977_RS19550	COG3663	DNA glycosylase
IE977_RS19685	COG4695	Portal protein
IE977_RS19730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IE977_RS19770	COG0582	viral genome integration into host DNA
IE977_RS19780	COG2375	cellular response to nickel ion
IE977_RS19785	COG1695	Transcriptional regulator
IE977_RS19790	COG0840	transmembrane signaling receptor activity
IE977_RS19795	COG0840	transmembrane signaling receptor activity
IE977_RS19800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IE977_RS19815	COG3121	Chaperone
IE977_RS19820	COG3188	usher protein
IE977_RS19830	COG3539	Fimbrial protein
IE977_RS19840	COG3121	Chaperone
IE977_RS19855	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IE977_RS19860	COG1830	Aldolase
IE977_RS19865	COG1879	ABC-type sugar transport system periplasmic component
IE977_RS19870	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS19875	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS19880	COG1129	ABC transporter
IE977_RS19885	COG2390	Transcriptional regulator
IE977_RS19890	COG1070	Carbohydrate kinase
IE977_RS19895	COG0446	pyridine nucleotide-disulphide oxidoreductase
IE977_RS19895	COG1902	pentaerythritol trinitrate reductase activity
IE977_RS19905	COG1451	nucleotide metabolic process
IE977_RS19910	COG0673	inositol 2-dehydrogenase activity
IE977_RS19915	COG0861	Integral membrane protein TerC family
IE977_RS19925	COG2721	sulfolactate sulfo-lyase activity
IE977_RS19935	COG2271	Major facilitator Superfamily
IE977_RS19940	COG2186	Transcriptional regulator
IE977_RS19945	COG0586	Pfam SNARE associated Golgi protein
IE977_RS19955	COG1422	Protein of unknown function (DUF1090)
IE977_RS19960	COG4575	ribosome binding
IE977_RS19965	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
IE977_RS19975	COG2259	Doxx family
IE977_RS19980	COG0435	Glutathione S-transferase
IE977_RS19985	COG3152	Membrane
IE977_RS19990	COG0583	DNA-binding transcription factor activity
IE977_RS19995	COG1741	Belongs to the pirin family
IE977_RS20005	COG0814	amino acid
IE977_RS20010	COG1882	Formate acetyltransferase
IE977_RS20015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IE977_RS20020	COG0814	amino acid
IE977_RS20025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IE977_RS20030	COG0583	DNA-binding transcription factor activity
IE977_RS20040	COG1929	Belongs to the glycerate kinase type-1 family
IE977_RS20045	COG2084	Dehydrogenase
IE977_RS20055	COG2721	sulfolactate sulfo-lyase activity
IE977_RS20060	COG1349	DNA-binding transcription factor activity
IE977_RS20070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS20080	COG3716	PTS system mannose fructose sorbose family IID component
IE977_RS20085	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS20090	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IE977_RS20095	COG2222	sugar isomerase
IE977_RS20100	COG0191	fructose-bisphosphate aldolase activity
IE977_RS20105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IE977_RS20105	COG1263	PTS System
IE977_RS20120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IE977_RS20125	COG3107	peptidoglycan biosynthetic process
IE977_RS20130	COG0792	nuclease activity
IE977_RS20135	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IE977_RS20140	COG2823	Periplasmic or secreted lipoprotein
IE977_RS20145	COG0701	Predicted permease
IE977_RS20150	COG0702	epimerase
IE977_RS20155	COG0693	protein deglycase activity
IE977_RS20160	COG3787	Belongs to the UPF0306 family
IE977_RS20165	COG2827	Endonuclease containing a URI domain
IE977_RS20170	COG3153	acetyltransferase
IE977_RS20175	COG3154	lipid carrier protein
IE977_RS20180	COG0826	peptidase U32
IE977_RS20185	COG0826	peptidase U32
IE977_RS20190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IE977_RS20195	COG0814	amino acid
IE977_RS20200	COG0513	Belongs to the DEAD box helicase family
IE977_RS20220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IE977_RS20225	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IE977_RS20230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IE977_RS20235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IE977_RS20255	COG0137	argininosuccinate synthase activity
IE977_RS20265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IE977_RS20270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IE977_RS20275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IE977_RS20285	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IE977_RS20290	COG1534	Rna-binding protein
IE977_RS20300	COG2027	D-alanyl-D-alanine carboxypeptidase
IE977_RS20305	COG0745	RESPONSE REGULATOR receiver
IE977_RS20310	COG0642	Histidine kinase
IE977_RS20315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IE977_RS20320	COG0697	spore germination
IE977_RS20330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IE977_RS20335	COG0142	geranyltranstransferase activity
IE977_RS20340	COG3423	Transcriptional regulator
IE977_RS20345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IE977_RS20350	COG5007	Belongs to the BolA IbaG family
IE977_RS20355	COG3113	response to antibiotic
IE977_RS20360	COG2854	intermembrane phospholipid transfer
IE977_RS20365	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IE977_RS20370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IE977_RS20375	COG1127	ABC transporter
IE977_RS20380	COG0530	calcium, potassium:sodium antiporter activity
IE977_RS20390	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IE977_RS20395	COG3117	lipopolysaccharide transmembrane transporter activity
IE977_RS20400	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IE977_RS20405	COG1137	ATPase activity
IE977_RS20410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IE977_RS20430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS20440	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
IE977_RS20445	COG0784	Response regulator, receiver
IE977_RS20445	COG2198	Histidine kinase
IE977_RS20445	COG5002	protein histidine kinase activity
IE977_RS20450	COG0795	lipopolysaccharide-transporting ATPase activity
IE977_RS20455	COG0795	lipopolysaccharide-transporting ATPase activity
IE977_RS20460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IE977_RS20465	COG2927	DNA polymerase III (CHI subunit)
IE977_RS20480	COG1064	alcohol dehydrogenase
IE977_RS20490	COG0433	COG0433 Predicted ATPase
IE977_RS20495	COG1242	4 iron, 4 sulfur cluster binding
IE977_RS20500	COG0067	glutamate synthase
IE977_RS20500	COG0069	glutamate synthase activity
IE977_RS20500	COG0070	glutamate synthase
IE977_RS20505	COG0493	'glutamate synthase
IE977_RS20510	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IE977_RS20515	COG0402	S-adenosylhomocysteine deaminase activity
IE977_RS20520	COG2731	YhcH YjgK YiaL family protein
IE977_RS20535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IE977_RS20540	COG2186	Transcriptional regulator
IE977_RS20545	COG2969	positive regulation of protein catabolic process
IE977_RS20550	COG0625	glutathione transferase activity
IE977_RS20555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IE977_RS20565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IE977_RS20570	COG3105	Protein conserved in bacteria
IE977_RS20575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE977_RS20580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IE977_RS20590	COG1438	arginine binding
IE977_RS20600	COG2732	(Barnase) inhibitor
IE977_RS20605	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS20610	COG1289	transmembrane transporter activity
IE977_RS20625	COG0583	DNA-binding transcription factor activity
IE977_RS20630	COG0312	modulator of DNA gyrase
IE977_RS20635	COG3164	Protein of unknown function
IE977_RS20650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IE977_RS20655	COG1792	Involved in formation and maintenance of cell shape
IE977_RS20660	COG1077	Cell shape determining protein MreB Mrl
IE977_RS20665	COG2199	diguanylate cyclase activity
IE977_RS20665	COG2200	EAL domain
IE977_RS20670	COG0604	alcohol dehydrogenase
IE977_RS20680	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IE977_RS20685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IE977_RS20690	COG0511	ligase activity, forming carbon-carbon bonds
IE977_RS20695	COG0439	Biotin carboxylase
IE977_RS20700	COG3924	membrane
IE977_RS20705	COG4145	pantothenate transmembrane transporter activity
IE977_RS20710	COG2264	protein methyltransferase activity
IE977_RS20740	COG1309	transcriptional regulator
IE977_RS20745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IE977_RS20750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IE977_RS20790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IE977_RS20800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IE977_RS20805	COG0009	L-threonylcarbamoyladenylate synthase
IE977_RS20810	COG0551	DNA topoisomerase type I activity
IE977_RS20815	COG2922	Belongs to the Smg family
IE977_RS20820	COG0758	DNA mediated transformation
IE977_RS20825	COG0242	peptide deformylase activity
IE977_RS20830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IE977_RS20835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IE977_RS20835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IE977_RS20845	COG1970	mechanosensitive ion channel activity
IE977_RS20850	COG3036	rescue of stalled ribosome
IE977_RS20855	COG0789	Transcriptional regulator
IE977_RS20870	COG0202	RNA polymerase activity
IE977_RS20880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IE977_RS20895	COG0201	protein transport
IE977_RS20905	COG1841	ribosomal large subunit assembly
IE977_RS20920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IE977_RS20925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IE977_RS20955	COG0255	Belongs to the universal ribosomal protein uL29 family
IE977_RS20960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IE977_RS21000	COG0051	transcription antitermination factor activity, RNA binding
IE977_RS21040	COG2168	tRNA wobble position uridine thiolation
IE977_RS21045	COG2923	Belongs to the DsrF TusC family
IE977_RS21050	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IE977_RS21055	COG2964	Protein conserved in bacteria
IE977_RS21060	COG0545	Peptidyl-prolyl cis-trans isomerase
IE977_RS21070	COG1047	Peptidyl-prolyl cis-trans
IE977_RS21075	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
IE977_RS21080	COG0475	glutathione-regulated potassium exporter activity
IE977_RS21080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IE977_RS21085	COG2249	NAD(P)H dehydrogenase (quinone) activity
IE977_RS21090	COG0488	(ABC) transporter
IE977_RS21100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IE977_RS21110	COG0679	Auxin Efflux Carrier
IE977_RS21140	COG0429	hydrolase of the alpha beta-hydrolase fold
IE977_RS21145	COG3089	Belongs to the UPF0270 family
IE977_RS21150	COG3954	Phosphoribulokinase
IE977_RS21155	COG1765	OsmC-like protein
IE977_RS21165	COG1289	transmembrane transporter activity
IE977_RS21170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IE977_RS21180	COG2184	nucleotidyltransferase activity
IE977_RS21190	COG0738	Major facilitator superfamily
IE977_RS21195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IE977_RS21205	COG1648	precorrin-2 dehydrogenase activity
IE977_RS21205	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IE977_RS21215	COG0180	Tryptophanyl-tRNA synthetase
IE977_RS21225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IE977_RS21230	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IE977_RS21235	COG3266	domain, Protein
IE977_RS21240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IE977_RS21245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IE977_RS21250	COG4796	Type ii and iii secretion system protein
IE977_RS21270	COG4972	Pilus assembly protein
IE977_RS21275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IE977_RS21280	COG0494	nUDIX hydrolase
IE977_RS21290	COG1011	Hydrolase
IE977_RS21295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IE977_RS21300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IE977_RS21305	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IE977_RS21320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IE977_RS21325	COG2183	response to ionizing radiation
IE977_RS21330	COG1918	ferrous iron import across plasma membrane
IE977_RS21350	COG1040	competence protein
IE977_RS21360	COG2610	gluconate transmembrane transporter activity
IE977_RS21365	COG1640	4-alpha-glucanotransferase
IE977_RS21370	COG0058	SHG alpha-glucan phosphorylase activity
IE977_RS21375	COG2909	trisaccharide binding
IE977_RS21380	COG1349	DNA-binding transcription factor activity
IE977_RS21385	COG0705	Rhomboid family
IE977_RS21390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IE977_RS21395	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IE977_RS21400	COG0058	SHG alpha-glucan phosphorylase activity
IE977_RS21405	COG0297	glycogen (starch) synthase activity
IE977_RS21410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IE977_RS21415	COG1523	belongs to the glycosyl hydrolase 13 family
IE977_RS21420	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IE977_RS21425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IE977_RS21430	COG2095	MarC family integral membrane protein
IE977_RS21440	COG2610	gluconate transmembrane transporter activity
IE977_RS21445	COG3265	gluconokinase activity
IE977_RS21450	COG1609	Transcriptional regulator
IE977_RS21455	COG1741	Belongs to the pirin family
IE977_RS21460	COG0673	inositol 2-dehydrogenase activity
IE977_RS21465	COG1247	-acetyltransferase
IE977_RS21470	COG0405	Gamma-glutamyltransferase
IE977_RS21480	COG0584	glycerophosphoryl diester phosphodiesterase
IE977_RS21510	COG0411	ABC transporter
IE977_RS21515	COG4177	L-phenylalanine transmembrane transporter activity
IE977_RS21525	COG0683	leucine binding
IE977_RS21530	COG0456	acetyltransferase
IE977_RS21535	COG2801	Transposase and inactivated derivatives
IE977_RS21535	COG3415	Transposase
IE977_RS21540	COG0683	leucine binding
IE977_RS21545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IE977_RS21550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IE977_RS21555	COG2177	Part of the ABC transporter FtsEX involved in
IE977_RS21560	COG2884	Cell division ATP-binding protein ftsE
IE977_RS21565	COG0552	protein localization to endoplasmic reticulum
IE977_RS21570	COG0742	ribosomal rna small subunit methyltransferase
IE977_RS21575	COG3776	membrane
IE977_RS21580	COG2801	Transposase and inactivated derivatives
IE977_RS21580	COG3415	Transposase
IE977_RS21590	COG3714	YhhN family
IE977_RS21610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IE977_RS21615	COG0425	Belongs to the sulfur carrier protein TusA family
IE977_RS21620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IE977_RS21630	COG0628	permease
IE977_RS21650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IE977_RS21670	COG1216	Glycosyl transferase, family 2
IE977_RS21695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE977_RS21705	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS21710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IE977_RS21755	COG3479	Phenolic acid decarboxylase
IE977_RS21760	COG0583	DNA-binding transcription factor activity
IE977_RS21765	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS21775	COG2801	Transposase and inactivated derivatives
IE977_RS21775	COG3415	Transposase
IE977_RS21785	COG2081	HI0933 family
IE977_RS21790	COG0306	phosphate transporter
IE977_RS21800	COG0589	response to stress
IE977_RS21805	COG0742	ribosomal rna small subunit methyltransferase
IE977_RS21810	COG0339	signal peptide processing
IE977_RS21815	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IE977_RS21820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IE977_RS21840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IE977_RS21850	COG2197	response regulator
IE977_RS21855	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS21860	COG0583	DNA-binding transcription factor activity
IE977_RS21865	COG1295	ribonuclease BN
IE977_RS21870	COG0477	Major facilitator Superfamily
IE977_RS21875	COG3415	Transposase
IE977_RS21875	COG2801	Transposase and inactivated derivatives
IE977_RS21880	COG2982	Protein involved in outer membrane biogenesis
IE977_RS21885	COG2200	EAL domain
IE977_RS21895	COG0612	Peptidase, M16
IE977_RS21900	COG1301	dicarboxylic acid transport
IE977_RS21905	COG2200	EAL domain
IE977_RS21905	COG2199	diguanylate cyclase activity
IE977_RS21910	COG0457	Tetratricopeptide repeat
IE977_RS21910	COG3118	belongs to the thioredoxin family
IE977_RS21915	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IE977_RS21920	COG1215	transferase activity, transferring glycosyl groups
IE977_RS21930	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IE977_RS21930	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IE977_RS21935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IE977_RS21965	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
IE977_RS21975	COG1739	Uncharacterized protein family UPF0029
IE977_RS21980	COG0006	proline dipeptidase activity
IE977_RS21985	COG1250	3-hydroxyacyl-CoA dehydrogenase
IE977_RS21985	COG1024	Enoyl-CoA hydratase
IE977_RS21990	COG0183	Belongs to the thiolase family
IE977_RS21995	COG0751	glycine-tRNA ligase activity
IE977_RS22000	COG0752	glycyl-tRNA synthetase alpha subunit
IE977_RS22010	COG3274	enterobacterial common antigen metabolic process
IE977_RS22015	COG1070	Carbohydrate kinase
IE977_RS22020	COG2115	Belongs to the xylose isomerase family
IE977_RS22025	COG4213	ABC transporter substrate-binding protein
IE977_RS22035	COG4214	carbohydrate transport
IE977_RS22040	COG1609	Transcriptional regulator
IE977_RS22040	COG2207	Transcriptional regulator
IE977_RS22045	COG2992	FlgJ-related protein
IE977_RS22050	COG0366	Alpha amylase catalytic
IE977_RS22055	COG3977	Valine--pyruvate aminotransferase
IE977_RS22060	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IE977_RS22065	COG1414	Transcriptional regulator
IE977_RS22075	COG2731	YhcH YjgK YiaL family protein
IE977_RS22085	COG2271	Major facilitator Superfamily
IE977_RS22090	COG1070	Carbohydrate kinase
IE977_RS22095	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IE977_RS22100	COG3623	hexulose-6-phosphate isomerase
IE977_RS22105	COG0235	Class ii aldolase
IE977_RS22115	COG2211	Major facilitator Superfamily
IE977_RS22125	COG1012	belongs to the aldehyde dehydrogenase family
IE977_RS22130	COG1940	carbohydrate kinase activity
IE977_RS22135	COG3276	selenocysteine insertion sequence binding
IE977_RS22145	COG0625	glutathione transferase activity
IE977_RS22150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IE977_RS22150	COG2213	PTS system mannitol-specific
IE977_RS22160	COG3722	fumarate hydratase activity
IE977_RS22180	COG3121	Chaperone
IE977_RS22185	COG3539	Fimbrial protein
IE977_RS22195	COG2186	Transcriptional regulator
IE977_RS22200	COG1304	FMN binding
IE977_RS22205	COG2271	Major facilitator Superfamily
IE977_RS22210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IE977_RS22220	COG0583	DNA-binding transcription factor activity
IE977_RS22225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IE977_RS22235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IE977_RS22240	COG3978	acetolactate synthase activity
IE977_RS22265	COG3085	chromosome segregation
IE977_RS22315	COG4206	TonB-dependent receptor
IE977_RS22320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IE977_RS22340	COG0583	DNA-binding transcription factor activity
IE977_RS22345	COG0165	Argininosuccinate lyase
IE977_RS22355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IE977_RS22360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IE977_RS22365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IE977_RS22370	COG0371	Dehydrogenase
IE977_RS22385	COG0527	aspartate kinase activity
IE977_RS22385	COG0460	homoserine dehydrogenase
IE977_RS22390	COG0626	cystathionine gamma-synthase activity
IE977_RS22400	COG0254	rRNA binding
IE977_RS22405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IE977_RS22410	COG1609	Transcriptional regulator
IE977_RS22415	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IE977_RS22430	COG1575	Belongs to the MenA family. Type 1 subfamily
IE977_RS22440	COG3074	FtsZ-dependent cytokinesis
IE977_RS22445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IE977_RS22455	COG1494	fructose-1,6-bisphosphatase
IE977_RS22465	COG3152	Membrane
IE977_RS22475	COG0149	triose-phosphate isomerase activity
IE977_RS22485	COG2134	cdp-diacylglycerol pyrophosphatase
IE977_RS22495	COG0205	6-phosphofructokinase activity
IE977_RS22505	COG3678	ATP-independent chaperone mediated protein folding
IE977_RS22510	COG0745	RESPONSE REGULATOR receiver
IE977_RS22515	COG2205	protein histidine kinase activity
IE977_RS22520	COG2258	MOSC domain
IE977_RS22525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IE977_RS22535	COG1917	Cupin 2, conserved barrel domain protein
IE977_RS22535	COG4977	sequence-specific DNA binding
IE977_RS22540	COG4977	sequence-specific DNA binding
IE977_RS22545	COG1070	Carbohydrate kinase
IE977_RS22550	COG4806	L-rhamnose isomerase
IE977_RS22555	COG0235	Class ii aldolase
IE977_RS22565	COG1129	ABC transporter
IE977_RS22570	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS22580	COG1454	alcohol dehydrogenase
IE977_RS22590	COG2211	Major facilitator Superfamily
IE977_RS22610	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IE977_RS22625	COG3188	usher protein
IE977_RS22630	COG3121	Chaperone
IE977_RS22655	COG0437	4 iron, 4 sulfur cluster binding
IE977_RS22660	COG2864	formate dehydrogenase
IE977_RS22665	COG3058	Necessary for formate dehydrogenase activity
IE977_RS22675	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
IE977_RS22685	COG0456	acetyltransferase
IE977_RS22700	COG1011	Hydrolase
IE977_RS22705	COG1349	DNA-binding transcription factor activity
IE977_RS22710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE977_RS22720	COG3684	Belongs to the aldolase LacD family
IE977_RS22730	COG1501	Belongs to the glycosyl hydrolase 31 family
IE977_RS22745	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IE977_RS22760	COG3852	Histidine kinase
IE977_RS22775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IE977_RS22780	COG3078	GTPase activator activity
IE977_RS22795	COG0204	Acyl-transferase
IE977_RS22805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IE977_RS22810	COG3084	Protein conserved in bacteria
IE977_RS22815	COG0746	molybdenum cofactor guanylyltransferase activity
IE977_RS22820	COG1763	Mo-molybdopterin cofactor biosynthetic process
IE977_RS22840	COG2186	Transcriptional regulator
IE977_RS22845	COG0477	Major facilitator Superfamily
IE977_RS22850	COG1609	Transcriptional regulator
IE977_RS22855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IE977_RS22865	COG1172	Belongs to the binding-protein-dependent transport system permease family
IE977_RS22870	COG1129	ABC transporter
IE977_RS22875	COG1869	D-ribose catabolic process
IE977_RS22880	COG3158	transport of potassium into the cell
IE977_RS22890	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IE977_RS22895	COG2502	aspartate--ammonia ligase
IE977_RS22900	COG1522	sequence-specific DNA binding
IE977_RS22905	COG0716	FMN binding
IE977_RS22910	COG0445	tRNA wobble uridine modification
IE977_RS22915	COG0357	Ribosomal RNA small subunit methyltransferase G
IE977_RS22920	COG3312	ion transport
IE977_RS22925	COG0356	it plays a direct role in the translocation of protons across the membrane
IE977_RS22935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IE977_RS22940	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IE977_RS22955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IE977_RS22960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IE977_RS22965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IE977_RS22975	COG3539	Fimbrial protein
IE977_RS22980	COG3121	Chaperone
IE977_RS22990	COG3539	Fimbrial protein
IE977_RS22995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IE977_RS23000	COG0573	inorganic phosphate transmembrane transporter activity
IE977_RS23005	COG0581	inorganic phosphate transmembrane transporter activity
IE977_RS23010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IE977_RS23015	COG0704	Plays a role in the regulation of phosphate uptake
IE977_RS23020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IE977_RS23025	COG2252	PERMEase
IE977_RS23030	COG0431	NADPH-dependent FMN reductase
IE977_RS23035	COG2091	lysine biosynthetic process via aminoadipic acid
IE977_RS23055	COG0706	membrane insertase activity
IE977_RS23135	COG1192	Involved in chromosome partitioning
IE977_RS23225	COG0210	DNA helicase
IE977_RS23375	COG4245	von Willebrand factor, type A
IE977_RS23380	COG4245	von Willebrand factor, type A
IE977_RS23410	COG1358	cellular component organization or biogenesis
IE977_RS23515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IE977_RS23520	COG1028	Short-chain dehydrogenase reductase Sdr
IE977_RS23525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IE977_RS23530	COG1902	pentaerythritol trinitrate reductase activity
IE977_RS23580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IE977_RS23660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE977_RS23750	COG0625	glutathione transferase activity
IE977_RS23765	COG0583	DNA-binding transcription factor activity
IE977_RS23775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IE977_RS23790	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IE977_RS23810	COG1846	Transcriptional regulator
IE977_RS23815	COG0583	DNA-binding transcription factor activity
IE977_RS23825	COG2948	multi-organism process
IE977_RS23925	COG5001	Diguanylate cyclase
IE977_RS23925	COG3300	MHYT domain
IE977_RS24005	COG3550	peptidyl-serine autophosphorylation
IE977_RS24060	COG3039	Transposase
IE977_RS24100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IE977_RS24110	COG0589	response to stress
IE977_RS24115	COG0659	secondary active sulfate transmembrane transporter activity
IE977_RS24125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IE977_RS24130	COG1393	Belongs to the ArsC family
IE977_RS24135	COG0431	NADPH-dependent FMN reductase
IE977_RS24170	COG2205	protein histidine kinase activity
IE977_RS24185	COG4372	Transposase
IE977_RS24190	COG3436	PFAM IS66 Orf2 family protein
IE977_RS24275	COG0659	secondary active sulfate transmembrane transporter activity
IE977_RS24280	COG0589	response to stress
IE977_RS24285	COG1393	Belongs to the ArsC family
IE977_RS24290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IE977_RS24295	COG0640	Transcriptional regulator
IE977_RS24300	COG0431	NADPH-dependent FMN reductase
IE977_RS24305	COG2801	Transposase and inactivated derivatives
IE977_RS24315	COG2801	Transposase and inactivated derivatives
IE977_RS24345	COG3039	Transposase
IE977_RS24385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IE977_RS24385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IE977_RS24405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IE977_RS24420	COG3157	Type VI secretion system effector, Hcp
IE977_RS24540	COG3436	PFAM IS66 Orf2 family protein
IE977_RS24545	COG4372	Transposase
IE977_RS24790	COG2890	protein-(glutamine-N5) methyltransferase activity
IE977_RS24850	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IE977_RS24885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IE977_RS24915	COG1902	pentaerythritol trinitrate reductase activity
IE977_RS24920	COG3118	belongs to the thioredoxin family
IE977_RS24925	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IE977_RS24970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IE977_RS25020	COG3335	DDE superfamily endonuclease
IE977_RS25100	COG1473	amidohydrolase
IE977_RS25145	COG3039	Transposase
IE977_RS25180	COG0732	type I restriction modification DNA specificity domain
IE977_RS25185	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IE977_RS25215	COG4644	lycopene metabolic process
IE977_RS25310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE977_RS25315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IE977_RS25515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IE977_RS25615	COG3173	Aminoglycoside phosphotransferase
IE977_RS25675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IE977_RS25715	COG3451	type IV secretory pathway VirB4