locus-tag	class	description
HA514_RS00010	COG0592	DNA-directed DNA polymerase activity
HA514_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HA514_RS00025	COG0583	DNA-binding transcription factor activity
HA514_RS00035	COG0561	phosphatase activity
HA514_RS00040	COG2186	Transcriptional regulator
HA514_RS00045	COG3734	2-keto-3-deoxy-galactonokinase
HA514_RS00050	COG0800	Aldolase
HA514_RS00055	COG4948	Mandelate Racemase Muconate Lactonizing
HA514_RS00060	COG2271	Major facilitator Superfamily
HA514_RS00065	COG0823	Involved in the tonB-independent uptake of proteins
HA514_RS00070	COG5645	(Lipo)protein
HA514_RS00080	COG0071	Belongs to the small heat shock protein (HSP20) family
HA514_RS00085	COG2985	domain, Protein
HA514_RS00090	COG2188	Transcriptional regulator
HA514_RS00105	COG2149	membrane
HA514_RS00120	COG2610	gluconate transmembrane transporter activity
HA514_RS00125	COG0583	DNA-binding transcription factor activity
HA514_RS00135	COG2814	Major facilitator Superfamily
HA514_RS00155	COG4680	protein conserved in bacteria
HA514_RS00160	COG5499	transcription regulator containing HTH domain
HA514_RS00170	COG0028	Belongs to the TPP enzyme family
HA514_RS00175	COG0440	acetolactate synthase activity
HA514_RS00180	COG2197	response regulator
HA514_RS00190	COG2271	Major facilitator Superfamily
HA514_RS00200	COG0596	Alpha beta hydrolase
HA514_RS00210	COG0583	DNA-binding transcription factor activity
HA514_RS00215	COG2814	Major facilitator Superfamily
HA514_RS00220	COG0667	Aldo Keto reductase
HA514_RS00230	COG0697	spore germination
HA514_RS00235	COG4580	involved in the transport of maltose and maltodextrins
HA514_RS00240	COG1447	Phosphotransferase system cellobiose-specific component IIA
HA514_RS00245	COG2723	6-phospho-beta-galactosidase activity
HA514_RS00250	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HA514_RS00250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HA514_RS00260	COG1609	Transcriptional regulator
HA514_RS00270	COG0454	-acetyltransferase
HA514_RS00275	COG1464	Belongs to the NlpA lipoprotein family
HA514_RS00280	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HA514_RS00300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HA514_RS00305	COG3272	Protein of unknown function (DUF1722)
HA514_RS00310	COG2351	hydroxyisourate hydrolase activity
HA514_RS00315	COG0789	Transcriptional regulator
HA514_RS00330	COG0519	Catalyzes the synthesis of GMP from XMP
HA514_RS00360	COG2211	Major facilitator Superfamily
HA514_RS00365	COG1501	Belongs to the glycosyl hydrolase 31 family
HA514_RS00370	COG2982	Protein involved in outer membrane biogenesis
HA514_RS00375	COG2233	PERMEase
HA514_RS00380	COG0786	glutamate:sodium symporter activity
HA514_RS00385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HA514_RS00390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HA514_RS00395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HA514_RS00405	COG0194	GDP metabolic process
HA514_RS00410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HA514_RS00415	COG2860	membrane
HA514_RS00420	COG1561	YicC-like family, N-terminal region
HA514_RS00430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HA514_RS00440	COG0756	dUTP diphosphatase activity
HA514_RS00445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HA514_RS00450	COG2003	Belongs to the UPF0758 family
HA514_RS00455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HA514_RS00460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HA514_RS00465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HA514_RS00470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HA514_RS00480	COG1519	Transferase
HA514_RS00485	COG1216	Glycosyl transferase, family 2
HA514_RS00490	COG0438	transferase activity, transferring glycosyl groups
HA514_RS00500	COG0859	PFAM glycosyl transferase family 9
HA514_RS00530	COG0859	PFAM glycosyl transferase family 9
HA514_RS00545	COG1063	alcohol dehydrogenase
HA514_RS00560	COG2861	carbohydrate metabolic process
HA514_RS00565	COG4942	peptidase
HA514_RS00570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HA514_RS00575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HA514_RS00580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HA514_RS00585	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HA514_RS00590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HA514_RS00600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HA514_RS00605	COG2271	Major facilitator Superfamily
HA514_RS00615	COG2186	Transcriptional regulator
HA514_RS00630	COG3722	fumarate hydratase activity
HA514_RS00640	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS00640	COG2213	PTS system mannitol-specific
HA514_RS00650	COG1566	PFAM secretion protein HlyD family protein
HA514_RS00655	COG0625	glutathione transferase activity
HA514_RS00665	COG3276	selenocysteine insertion sequence binding
HA514_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS00690	COG3713	MltA-interacting MipA family protein
HA514_RS00700	COG2211	Major facilitator Superfamily
HA514_RS00710	COG3977	Valine--pyruvate aminotransferase
HA514_RS00715	COG0366	Alpha amylase catalytic
HA514_RS00720	COG2992	FlgJ-related protein
HA514_RS00725	COG1609	Transcriptional regulator
HA514_RS00725	COG2207	Transcriptional regulator
HA514_RS00730	COG4214	carbohydrate transport
HA514_RS00740	COG4213	ABC transporter substrate-binding protein
HA514_RS00745	COG2115	Belongs to the xylose isomerase family
HA514_RS00750	COG1070	Carbohydrate kinase
HA514_RS00755	COG1335	isochorismatase
HA514_RS00765	COG3274	enterobacterial common antigen metabolic process
HA514_RS00775	COG0752	glycyl-tRNA synthetase alpha subunit
HA514_RS00780	COG0751	glycine-tRNA ligase activity
HA514_RS00790	COG2944	sequence-specific DNA binding
HA514_RS00800	COG1278	Cold shock
HA514_RS00805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HA514_RS00815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA514_RS00825	COG1609	Transcriptional regulator
HA514_RS00830	COG2885	chlorophyll binding
HA514_RS00835	COG0243	molybdopterin cofactor binding
HA514_RS00840	COG0456	acetyltransferase
HA514_RS00845	COG2818	Glycosylase
HA514_RS00850	COG5571	outer membrane autotransporter
HA514_RS00855	COG2223	nitrite transmembrane transporter activity
HA514_RS00860	COG2194	sulfuric ester hydrolase activity
HA514_RS00870	COG0747	negative chemotaxis
HA514_RS00875	COG0601	transmembrane transport
HA514_RS00880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA514_RS00885	COG0444	Belongs to the ABC transporter superfamily
HA514_RS00890	COG4608	Belongs to the ABC transporter superfamily
HA514_RS00895	COG1072	(Pantothenic acid kinase))
HA514_RS00930	COG0250	Participates in transcription elongation, termination and antitermination
HA514_RS00975	COG3706	GGDEF domain
HA514_RS00980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HA514_RS00985	COG2022	thiamine diphosphate biosynthetic process
HA514_RS00990	COG2104	thiamine diphosphate biosynthetic process
HA514_RS00995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HA514_RS01010	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HA514_RS01015	COG2816	NAD+ diphosphatase activity
HA514_RS01020	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HA514_RS01025	COG1515	deoxyribonuclease V activity
HA514_RS01030	COG3068	Protein conserved in bacteria
HA514_RS01045	COG0151	Belongs to the GarS family
HA514_RS01075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HA514_RS01085	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HA514_RS01115	COG1187	pseudouridine synthase activity
HA514_RS01130	COG0527	aspartate kinase activity
HA514_RS01155	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HA514_RS01160	COG3223	Belongs to the PsiE family
HA514_RS01185	COG4580	involved in the transport of maltose and maltodextrins
HA514_RS01195	COG3161	chorismate lyase activity
HA514_RS01205	COG2217	Heavy metal translocating P-type atpase
HA514_RS01210	COG3714	YhhN family
HA514_RS01220	COG3776	membrane
HA514_RS01225	COG0742	ribosomal rna small subunit methyltransferase
HA514_RS01230	COG0552	protein localization to endoplasmic reticulum
HA514_RS01235	COG2884	Cell division ATP-binding protein ftsE
HA514_RS01240	COG2177	Part of the ABC transporter FtsEX involved in
HA514_RS01245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HA514_RS01250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HA514_RS01255	COG0683	leucine binding
HA514_RS01265	COG0683	leucine binding
HA514_RS01275	COG4177	L-phenylalanine transmembrane transporter activity
HA514_RS01280	COG0411	ABC transporter
HA514_RS01310	COG0584	glycerophosphoryl diester phosphodiesterase
HA514_RS01320	COG0405	Gamma-glutamyltransferase
HA514_RS01325	COG1247	-acetyltransferase
HA514_RS01330	COG0673	inositol 2-dehydrogenase activity
HA514_RS01335	COG1741	Belongs to the pirin family
HA514_RS01340	COG1609	Transcriptional regulator
HA514_RS01345	COG3265	gluconokinase activity
HA514_RS01350	COG2610	gluconate transmembrane transporter activity
HA514_RS01355	COG2937	Belongs to the GPAT DAPAT family
HA514_RS01360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HA514_RS01365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HA514_RS01370	COG0534	Mate efflux family protein
HA514_RS01375	COG3237	CsbD-like
HA514_RS01380	COG0735	belongs to the Fur family
HA514_RS01395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HA514_RS01405	COG0604	alcohol dehydrogenase
HA514_RS01410	COG0305	Participates in initiation and elongation during chromosome replication
HA514_RS01420	COG1448	Aminotransferase
HA514_RS01425	COG3700	Belongs to the class B bacterial acid phosphatase family
HA514_RS01430	COG0432	Pfam Uncharacterised protein family UPF0047
HA514_RS01435	COG2315	Protein conserved in bacteria
HA514_RS01445	COG0629	single-stranded DNA binding
HA514_RS01455	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HA514_RS01465	COG0789	Transcriptional regulator
HA514_RS01470	COG0625	glutathione transferase activity
HA514_RS01475	COG2252	PERMEase
HA514_RS01480	COG0025	NhaP-type Na H and K H
HA514_RS01485	COG0583	DNA-binding transcription factor activity
HA514_RS01495	COG1346	cytolysis
HA514_RS01500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HA514_RS01505	COG3162	membrane
HA514_RS01510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HA514_RS01515	COG1301	dicarboxylic acid transport
HA514_RS01520	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HA514_RS01530	COG0745	RESPONSE REGULATOR receiver
HA514_RS01540	COG0191	fructose-bisphosphate aldolase activity
HA514_RS01555	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA514_RS01560	COG1129	ABC transporter
HA514_RS01575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HA514_RS01580	COG0456	acetyltransferase
HA514_RS01585	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HA514_RS01590	COG3454	Phosphonate metabolism
HA514_RS01595	COG4778	phosphonate C-P lyase system protein PhnL
HA514_RS01600	COG4107	phosphonate C-P lyase system protein PhnK
HA514_RS01605	COG3627	carbon phosphorus lyase activity
HA514_RS01610	COG3626	phosphonate metabolism
HA514_RS01615	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HA514_RS01620	COG3624	Phosphonate C-P lyase system protein PhnG
HA514_RS01625	COG2188	Transcriptional regulator
HA514_RS01630	COG3639	organic phosphonate transmembrane transporter activity
HA514_RS01635	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HA514_RS01645	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HA514_RS01650	COG2824	Alkylphosphonate utilization operon protein PhnA
HA514_RS01655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HA514_RS01675	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HA514_RS01710	COG2003	Belongs to the UPF0758 family
HA514_RS01730	COG1309	transcriptional regulator
HA514_RS01745	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HA514_RS01750	COG1027	Aspartate ammonia-lyase
HA514_RS01755	COG3030	protein affecting phage T7 exclusion by the F plasmid
HA514_RS01760	COG0531	amino acid
HA514_RS01770	COG0459	protein refolding
HA514_RS01775	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HA514_RS01780	COG0700	Nucleoside recognition
HA514_RS01785	COG3366	ferrous iron transmembrane transporter activity
HA514_RS01795	COG1509	lysine 2,3-aminomutase activity
HA514_RS01805	COG5510	response to toxic substance
HA514_RS01835	COG0583	DNA-binding transcription factor activity
HA514_RS01845	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HA514_RS01850	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HA514_RS01855	COG1053	succinate dehydrogenase
HA514_RS01860	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HA514_RS01870	COG3264	Mechanosensitive ion channel
HA514_RS01870	COG1511	domain protein
HA514_RS01885	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HA514_RS01905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HA514_RS01910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HA514_RS01910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HA514_RS01915	COG0802	atpase or kinase
HA514_RS01925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HA514_RS01930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HA514_RS01935	COG1923	regulation of RNA biosynthetic process
HA514_RS01940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HA514_RS01945	COG0330	HflC and HflK could
HA514_RS01950	COG0330	HflC and HflK could
HA514_RS01955	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HA514_RS01965	COG1959	2 iron, 2 sulfur cluster binding
HA514_RS01970	COG0557	exoribonuclease II activity
HA514_RS01975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HA514_RS01980	COG0477	Major facilitator Superfamily
HA514_RS01985	COG1960	acyl-CoA dehydrogenase activity
HA514_RS01990	COG0840	transmembrane signaling receptor activity
HA514_RS02000	COG3650	response to hydrogen peroxide
HA514_RS02005	COG1073	alpha beta
HA514_RS02060	COG2965	DNA replication, synthesis of RNA primer
HA514_RS02065	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HA514_RS02070	COG0359	binds to the 23S rRNA
HA514_RS02075	COG3061	Opacity-associated protein A
HA514_RS02080	COG0545	Peptidyl-prolyl cis-trans isomerase
HA514_RS02085	COG1113	amino acid transport
HA514_RS02095	COG0840	transmembrane signaling receptor activity
HA514_RS02100	COG0697	spore germination
HA514_RS02110	COG0702	epimerase
HA514_RS02115	COG1733	regulation of RNA biosynthetic process
HA514_RS02125	COG1218	3'(2'),5'-bisphosphate nucleotidase
HA514_RS02130	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HA514_RS02140	COG1253	flavin adenine dinucleotide binding
HA514_RS02145	COG2211	Major facilitator Superfamily
HA514_RS02160	COG0673	inositol 2-dehydrogenase activity
HA514_RS02165	COG0673	inositol 2-dehydrogenase activity
HA514_RS02170	COG1609	Transcriptional regulator
HA514_RS02175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HA514_RS02180	COG0729	surface antigen
HA514_RS02185	COG2911	Protein conserved in bacteria
HA514_RS02190	COG2105	PFAM AIG2 family protein
HA514_RS02195	COG2336	PFAM SpoVT AbrB
HA514_RS02200	COG2337	Toxic component of a toxin-antitoxin (TA) module
HA514_RS02210	COG1879	ABC-type sugar transport system periplasmic component
HA514_RS02215	COG1129	ABC transporter
HA514_RS02220	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA514_RS02225	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA514_RS02235	COG0583	DNA-binding transcription factor activity
HA514_RS02245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HA514_RS02250	COG3028	Belongs to the UPF0307 family
HA514_RS02255	COG0312	modulator of DNA gyrase
HA514_RS02290	COG3964	amidohydrolase
HA514_RS02310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS02310	COG3711	transcriptional antiterminator
HA514_RS02315	COG0602	queuosine metabolic process
HA514_RS02325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HA514_RS02325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HA514_RS02325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS02350	COG0366	Alpha amylase catalytic
HA514_RS02355	COG1263	PTS System
HA514_RS02355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA514_RS02360	COG1609	Transcriptional regulator
HA514_RS02370	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HA514_RS02375	COG3397	chitin binding
HA514_RS02380	COG0251	oxidation-reduction process
HA514_RS02390	COG0540	Belongs to the ATCase OTCase family
HA514_RS02405	COG1438	arginine binding
HA514_RS02410	COG1288	antiporter activity
HA514_RS02425	COG2235	arginine
HA514_RS02430	COG2731	YhcH YjgK YiaL family protein
HA514_RS02435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HA514_RS02445	COG2211	Major facilitator Superfamily
HA514_RS02450	COG3507	Belongs to the glycosyl hydrolase 43 family
HA514_RS02455	COG1414	Transcriptional regulator
HA514_RS02460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HA514_RS02485	COG0582	viral genome integration into host DNA
HA514_RS02540	COG1609	Transcriptional regulator
HA514_RS02550	COG2211	Major facilitator Superfamily
HA514_RS02575	COG1335	isochorismatase
HA514_RS02605	COG0740	serine-type endopeptidase activity
HA514_RS02610	COG2850	peptidyl-arginine hydroxylation
HA514_RS02620	COG5457	Domain of unknown function (DUF1127)
HA514_RS02630	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HA514_RS02635	COG0583	DNA-binding transcription factor activity
HA514_RS02640	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS02655	COG0640	Transcriptional regulator
HA514_RS02685	COG0583	DNA-binding transcription factor activity
HA514_RS02690	COG2733	membrane
HA514_RS02720	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS02740	COG0523	cobalamin synthesis protein
HA514_RS02745	COG2879	small protein
HA514_RS02750	COG1966	Carbon starvation protein
HA514_RS02760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HA514_RS02765	COG2368	4-hydroxyphenylacetate
HA514_RS02785	COG3971	2-oxopent-4-enoate hydratase activity
HA514_RS02795	COG3384	dioxygenase
HA514_RS02800	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS02805	COG0179	Fumarylacetoacetate (FAA) hydrolase
HA514_RS02810	COG1846	Transcriptional regulator
HA514_RS02815	COG0840	transmembrane signaling receptor activity
HA514_RS02875	COG1484	DNA-dependent DNA replication
HA514_RS02885	COG1764	response to oxidative stress
HA514_RS02890	COG1846	Transcriptional regulator
HA514_RS02895	COG1309	transcriptional regulator
HA514_RS02900	COG3610	response to peptide
HA514_RS02905	COG2966	Psort location CytoplasmicMembrane, score
HA514_RS02910	COG2197	response regulator
HA514_RS02915	COG2197	response regulator
HA514_RS02920	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HA514_RS02925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HA514_RS02930	COG4114	ferric iron reductase
HA514_RS02935	COG3706	GGDEF domain
HA514_RS02960	COG2813	Specifically methylates the guanine in position
HA514_RS02965	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HA514_RS02970	COG0456	acetyltransferase
HA514_RS02975	COG1011	Hydrolase
HA514_RS02980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HA514_RS02985	COG2823	Periplasmic or secreted lipoprotein
HA514_RS02990	COG5487	UPF0391 membrane protein
HA514_RS02995	COG4667	esterase of the alpha-beta hydrolase superfamily
HA514_RS03000	COG0084	hydrolase, TatD family'
HA514_RS03005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HA514_RS03010	COG1328	CTP reductase activity
HA514_RS03045	COG3188	usher protein
HA514_RS03050	COG3121	Chaperone
HA514_RS03060	COG3539	Fimbrial protein
HA514_RS03070	COG3726	membrane protein affecting hemolysin expression
HA514_RS03075	COG0560	Phosphoserine phosphatase
HA514_RS03090	COG0604	alcohol dehydrogenase
HA514_RS03100	COG0488	(ABC) transporter
HA514_RS03105	COG0741	lytic transglycosylase activity
HA514_RS03110	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HA514_RS03115	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HA514_RS03120	COG0406	alpha-ribazole phosphatase activity
HA514_RS03125	COG3708	Transcriptional regulator
HA514_RS03125	COG2207	Transcriptional regulator
HA514_RS03130	COG3045	CreA protein
HA514_RS03135	COG0745	RESPONSE REGULATOR receiver
HA514_RS03140	COG2205	protein histidine kinase activity
HA514_RS03145	COG4452	Inner membrane protein CreD
HA514_RS03150	COG0745	RESPONSE REGULATOR receiver
HA514_RS03160	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HA514_RS03170	COG0460	homoserine dehydrogenase
HA514_RS03170	COG0527	aspartate kinase activity
HA514_RS03180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HA514_RS03190	COG3022	response to hydroperoxide
HA514_RS03195	COG1115	amino acid carrier protein
HA514_RS03205	COG0521	Mo-molybdopterin cofactor biosynthetic process
HA514_RS03210	COG0477	Major facilitator Superfamily
HA514_RS03215	COG1584	GPR1 FUN34 yaaH family protein
HA514_RS03230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HA514_RS03235	COG0583	DNA-binding transcription factor activity
HA514_RS03240	COG0268	Binds directly to 16S ribosomal RNA
HA514_RS03250	COG0196	riboflavin kinase activity
HA514_RS03265	COG1047	Peptidyl-prolyl cis-trans
HA514_RS03270	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HA514_RS03280	COG0505	Belongs to the CarA family
HA514_RS03300	COG2249	NAD(P)H dehydrogenase (quinone) activity
HA514_RS03305	COG0475	glutathione-regulated potassium exporter activity
HA514_RS03305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HA514_RS03315	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HA514_RS03320	COG2967	ApaG domain
HA514_RS03330	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HA514_RS03340	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HA514_RS03345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HA514_RS03350	COG0564	pseudouridine synthase activity
HA514_RS03355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HA514_RS03360	COG0417	DNA replication proofreading
HA514_RS03365	COG0235	Class ii aldolase
HA514_RS03370	COG2160	L-arabinose isomerase activity
HA514_RS03375	COG1069	ribulokinase activity
HA514_RS03385	COG0586	Pfam SNARE associated Golgi protein
HA514_RS03395	COG1178	ABC-type Fe3 transport system permease component
HA514_RS03415	COG2814	Major facilitator Superfamily
HA514_RS03440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HA514_RS03455	COG0028	Belongs to the TPP enzyme family
HA514_RS03465	COG1609	Transcriptional regulator
HA514_RS03470	COG2001	Belongs to the MraZ family
HA514_RS03485	COG0768	penicillin binding
HA514_RS03490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HA514_RS03495	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HA514_RS03500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HA514_RS03510	COG0772	Belongs to the SEDS family
HA514_RS03525	COG1181	Belongs to the D-alanine--D-alanine ligase family
HA514_RS03535	COG0849	cell division
HA514_RS03540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HA514_RS03545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HA514_RS03555	COG0653	protein targeting
HA514_RS03560	COG0494	nUDIX hydrolase
HA514_RS03570	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HA514_RS03580	COG0516	GMP reductase activity
HA514_RS03585	COG1459	type II secretion system
HA514_RS03590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HA514_RS03595	COG4969	Belongs to the N-Me-Phe pilin family
HA514_RS03605	COG3023	N-Acetylmuramoyl-L-alanine amidase
HA514_RS03610	COG3725	Membrane protein required for beta-lactamase induction
HA514_RS03615	COG3940	Belongs to the glycosyl hydrolase 43 family
HA514_RS03620	COG2211	Major facilitator Superfamily
HA514_RS03625	COG1113	amino acid transport
HA514_RS03635	COG2186	Transcriptional regulator
HA514_RS03640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HA514_RS03645	COG0508	dehydrogenase complex catalyzes the overall conversion of
HA514_RS03650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HA514_RS03665	COG3064	Membrane
HA514_RS03710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HA514_RS03725	COG4993	Dehydrogenase
HA514_RS03735	COG0288	reversible hydration of carbon dioxide
HA514_RS03740	COG1131	(ABC) transporter
HA514_RS03745	COG0842	Transport permease protein
HA514_RS03750	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS03755	COG0726	polysaccharide deacetylase
HA514_RS03780	COG3188	usher protein
HA514_RS03785	COG3121	Chaperone
HA514_RS03795	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HA514_RS03800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HA514_RS03805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HA514_RS03810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HA514_RS03815	COG0617	tRNA 3'-terminal CCA addition
HA514_RS03820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HA514_RS03830	COG1489	DNA binding
HA514_RS03835	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HA514_RS03840	COG1643	Atp-dependent helicase
HA514_RS03845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HA514_RS03855	COG3121	Chaperone
HA514_RS03860	COG3188	usher protein
HA514_RS03870	COG4774	siderophore transport
HA514_RS03875	COG1120	ATPase activity
HA514_RS03880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HA514_RS03885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA514_RS03890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HA514_RS03900	COG0316	Belongs to the HesB IscA family
HA514_RS03905	COG2860	membrane
HA514_RS03915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HA514_RS03920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HA514_RS03930	COG3835	regulator
HA514_RS03965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HA514_RS03980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HA514_RS03990	COG0575	Belongs to the CDS family
HA514_RS03995	COG0750	zinc metalloprotease
HA514_RS04000	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HA514_RS04005	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HA514_RS04010	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HA514_RS04015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HA514_RS04020	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HA514_RS04025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HA514_RS04030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HA514_RS04040	COG0825	malonyl-CoA metabolic process
HA514_RS04050	COG0346	lactoylglutathione lyase activity
HA514_RS04055	COG0037	tRNA processing
HA514_RS04060	COG4568	rho-dependent transcription termination
HA514_RS04075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HA514_RS04080	COG3015	lipoprotein NlpE involved in copper resistance
HA514_RS04090	COG1720	tRNA m6t6A37 methyltransferase activity
HA514_RS04100	COG1464	Belongs to the NlpA lipoprotein family
HA514_RS04105	COG2011	ABC-type metal ion transport system permease component
HA514_RS04115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HA514_RS04155	COG0583	DNA-binding transcription factor activity
HA514_RS04160	COG2814	Major facilitator Superfamily
HA514_RS04165	COG3021	interspecies interaction between organisms
HA514_RS04170	COG2226	methyltransferase
HA514_RS04175	COG0741	lytic transglycosylase activity
HA514_RS04175	COG1388	LysM domain
HA514_RS04180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HA514_RS04185	COG2226	methyltransferase
HA514_RS04195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HA514_RS04210	COG0444	Belongs to the ABC transporter superfamily
HA514_RS04215	COG4608	Belongs to the ABC transporter superfamily
HA514_RS04240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HA514_RS04245	COG1960	acyl-CoA dehydrogenase activity
HA514_RS04255	COG0121	glutamine amidotransferase
HA514_RS04260	COG3034	peptidoglycan biosynthetic process
HA514_RS04275	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HA514_RS04280	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HA514_RS04295	COG2991	Protein conserved in bacteria
HA514_RS04300	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HA514_RS04305	COG2195	Cleaves the N-terminal amino acid of tripeptides
HA514_RS04325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HA514_RS04330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HA514_RS04335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HA514_RS04345	COG0582	viral genome integration into host DNA
HA514_RS04530	COG0463	Glycosyl transferase, family 2
HA514_RS04535	COG2246	polysaccharide biosynthetic process
HA514_RS04545	COG3772	lysozyme
HA514_RS04565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HA514_RS04575	COG3300	MHYT domain
HA514_RS04575	COG5001	Diguanylate cyclase
HA514_RS04590	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS04595	COG0583	DNA-binding transcription factor activity
HA514_RS04605	COG0628	permease
HA514_RS04610	COG0833	amino acid
HA514_RS04615	COG2040	homocysteine
HA514_RS04620	COG4521	taurine ABC transporter
HA514_RS04625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HA514_RS04630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HA514_RS04635	COG2175	clavaminate synthase activity
HA514_RS04645	COG0113	porphobilinogen synthase activity
HA514_RS04660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HA514_RS04670	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HA514_RS04690	COG1181	Belongs to the D-alanine--D-alanine ligase family
HA514_RS04715	COG3706	GGDEF domain
HA514_RS04720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HA514_RS04725	COG1671	Belongs to the UPF0178 family
HA514_RS04730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HA514_RS04740	COG4126	flavin adenine dinucleotide binding
HA514_RS04745	COG3123	guanosine phosphorylase activity
HA514_RS04755	COG1940	carbohydrate kinase activity
HA514_RS04760	COG0419	ATPase involved in DNA repair
HA514_RS04765	COG0420	3'-5' exonuclease activity
HA514_RS04775	COG5002	protein histidine kinase activity
HA514_RS04790	COG0366	Alpha amylase catalytic
HA514_RS04805	COG0450	alkyl hydroperoxide reductase
HA514_RS04810	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HA514_RS04825	COG1862	Preprotein translocase
HA514_RS04835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HA514_RS04850	COG3248	Nucleoside-binding outer membrane protein
HA514_RS04860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HA514_RS04865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HA514_RS04865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HA514_RS04870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HA514_RS04880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HA514_RS04885	COG0667	Aldo Keto reductase
HA514_RS04890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HA514_RS04895	COG0142	geranyltranstransferase activity
HA514_RS04915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HA514_RS04925	COG2814	Major facilitator Superfamily
HA514_RS04930	COG0109	protoheme IX farnesyltransferase activity
HA514_RS04935	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HA514_RS04940	COG1845	cytochrome c oxidase, subunit III
HA514_RS04945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HA514_RS04950	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HA514_RS04955	COG2223	nitrite transmembrane transporter activity
HA514_RS04960	COG3056	Lipoprotein
HA514_RS04965	COG0271	Belongs to the BolA IbaG family
HA514_RS04970	COG0544	peptidyl-prolyl cis-trans isomerase activity
HA514_RS04980	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HA514_RS04985	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HA514_RS04990	COG0776	regulation of translation
HA514_RS04995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HA514_RS05000	COG1555	photosystem II stabilization
HA514_RS05005	COG0824	Thioesterase
HA514_RS05010	COG3657	addiction module killer protein
HA514_RS05025	COG4533	DNA binding
HA514_RS05030	COG0561	phosphatase activity
HA514_RS05040	COG1522	sequence-specific DNA binding
HA514_RS05045	COG1132	(ABC) transporter
HA514_RS05050	COG1132	(ABC) transporter
HA514_RS05055	COG0347	Belongs to the P(II) protein family
HA514_RS05060	COG0004	ammonium transporteR
HA514_RS05065	COG1946	Acyl-CoA thioesterase
HA514_RS05070	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HA514_RS05075	COG3695	enzyme binding
HA514_RS05095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HA514_RS05100	COG2364	Membrane
HA514_RS05105	COG1609	Transcriptional regulator
HA514_RS05115	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HA514_RS05125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HA514_RS05145	COG0110	maltose O-acetyltransferase activity
HA514_RS05160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HA514_RS05165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HA514_RS05170	COG1309	transcriptional regulator
HA514_RS05175	COG1196	nuclear chromosome segregation
HA514_RS05175	COG3264	Mechanosensitive ion channel
HA514_RS05185	COG3923	Primosomal replication protein n
HA514_RS05190	COG2832	Protein of unknown function (DUF454)
HA514_RS05195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HA514_RS05205	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HA514_RS05210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HA514_RS05215	COG0326	Molecular chaperone. Has ATPase activity
HA514_RS05225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HA514_RS05230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA514_RS05235	COG4651	solute:proton antiporter activity
HA514_RS05235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HA514_RS05240	COG2223	nitrite transmembrane transporter activity
HA514_RS05245	COG0737	Belongs to the 5'-nucleotidase family
HA514_RS05250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HA514_RS05255	COG3735	TraB family
HA514_RS05260	COG2217	Heavy metal translocating P-type atpase
HA514_RS05270	COG1585	Membrane protein implicated in regulation of membrane protease activity
HA514_RS05275	COG0330	HflC and HflK could
HA514_RS05280	COG4619	ABC transporter
HA514_RS05285	COG0390	transport system, permease component
HA514_RS05290	COG3118	belongs to the thioredoxin family
HA514_RS05295	COG0300	oxidoreductase activity
HA514_RS05300	COG2755	lipolytic protein G-D-S-L family
HA514_RS05305	COG4181	ATPase activity
HA514_RS05310	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HA514_RS05315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HA514_RS05325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HA514_RS05330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HA514_RS05335	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HA514_RS05340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HA514_RS05350	COG1988	membrane-bound metal-dependent
HA514_RS05355	COG1609	Transcriptional regulator
HA514_RS05360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA514_RS05360	COG2190	(PTS) system
HA514_RS05360	COG1263	PTS System
HA514_RS05365	COG2501	S4 domain
HA514_RS05605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HA514_RS05680	COG5410	chromosome segregation
HA514_RS05860	COG1113	amino acid transport
HA514_RS05865	COG1396	sequence-specific DNA binding
HA514_RS05875	COG2211	Major facilitator Superfamily
HA514_RS05890	COG1609	Transcriptional regulator
HA514_RS05895	COG0668	transmembrane transport
HA514_RS05900	COG0477	Major facilitator Superfamily
HA514_RS05915	COG0778	Nitroreductase
HA514_RS05920	COG2315	Protein conserved in bacteria
HA514_RS05935	COG2207	Transcriptional regulator
HA514_RS05960	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HA514_RS05970	COG2207	Transcriptional regulator
HA514_RS05975	COG1289	transmembrane transporter activity
HA514_RS05985	COG1566	PFAM secretion protein HlyD family protein
HA514_RS06025	COG0745	RESPONSE REGULATOR receiver
HA514_RS06030	COG5002	protein histidine kinase activity
HA514_RS06090	COG4608	Belongs to the ABC transporter superfamily
HA514_RS06095	COG0444	Belongs to the ABC transporter superfamily
HA514_RS06105	COG0601	transmembrane transport
HA514_RS06120	COG4221	oxidoreductase activity
HA514_RS06135	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HA514_RS06155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HA514_RS06160	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HA514_RS06175	COG1121	(ABC) transporter
HA514_RS06180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HA514_RS06185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HA514_RS06190	COG2977	Belongs to the P-Pant transferase superfamily
HA514_RS06195	COG4771	TonB-dependent receptor
HA514_RS06200	COG2382	esterase
HA514_RS06205	COG3251	PFAM MbtH domain protein
HA514_RS06210	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HA514_RS06210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HA514_RS06215	COG1120	ATPase activity
HA514_RS06220	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA514_RS06225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA514_RS06235	COG4592	Periplasmic binding protein
HA514_RS06240	COG1169	isochorismate synthase
HA514_RS06245	COG1021	2,3-dihydroxybenzoate-AMP ligase
HA514_RS06250	COG3433	isochorismatase activity
HA514_RS06250	COG1535	isochorismatase
HA514_RS06255	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS06260	COG2050	protein possibly involved in aromatic compounds catabolism
HA514_RS06265	COG1966	Carbon starvation protein
HA514_RS06270	COG2879	small protein
HA514_RS06290	COG0371	Dehydrogenase
HA514_RS06295	COG1129	ABC transporter
HA514_RS06300	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA514_RS06315	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HA514_RS06335	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HA514_RS06340	COG0235	Class ii aldolase
HA514_RS06345	COG0436	Aminotransferase
HA514_RS06350	COG1475	DNA binding
HA514_RS06355	COG3969	phosphoadenosine phosphosulfate
HA514_RS06360	COG0583	DNA-binding transcription factor activity
HA514_RS06380	COG0243	molybdopterin cofactor binding
HA514_RS06400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HA514_RS06410	COG3719	Belongs to the RNase T2 family
HA514_RS06415	COG3069	C4-dicarboxylate transmembrane transporter activity
HA514_RS06430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HA514_RS06435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HA514_RS06440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HA514_RS06445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HA514_RS06450	COG0583	DNA-binding transcription factor activity
HA514_RS06455	COG0321	lipoyl(octanoyl) transferase activity
HA514_RS06465	COG1686	Belongs to the peptidase S11 family
HA514_RS06470	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HA514_RS06475	COG0772	Belongs to the SEDS family
HA514_RS06480	COG0768	penicillin binding
HA514_RS06490	COG0799	negative regulation of ribosome biogenesis
HA514_RS06500	COG1466	dna polymerase III delta subunit
HA514_RS06515	COG2888	peptidyl-tyrosine sulfation
HA514_RS06520	COG1957	nucleoside hydrolase
HA514_RS06525	COG1126	abc transporter atp-binding protein
HA514_RS06530	COG0765	amino acid transport
HA514_RS06535	COG0765	amino acid transport
HA514_RS06555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HA514_RS06560	COG1702	phosphate starvation-inducible protein PhoH
HA514_RS06565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HA514_RS06570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HA514_RS06610	COG0367	asparagine synthase
HA514_RS06615	COG0647	UMP catabolic process
HA514_RS06620	COG1846	Transcriptional regulator
HA514_RS06620	COG1940	carbohydrate kinase activity
HA514_RS06625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HA514_RS06635	COG1263	PTS System
HA514_RS06635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA514_RS06635	COG2190	(PTS) system
HA514_RS06640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HA514_RS06655	COG0735	belongs to the Fur family
HA514_RS06670	COG0596	Alpha beta hydrolase
HA514_RS06675	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HA514_RS06680	COG0033	Phosphoglucomutase
HA514_RS06685	COG0531	amino acid
HA514_RS06690	COG1982	Orn Lys Arg decarboxylase major
HA514_RS06700	COG0745	RESPONSE REGULATOR receiver
HA514_RS06705	COG2205	protein histidine kinase activity
HA514_RS06710	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HA514_RS06715	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HA514_RS06720	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HA514_RS06735	COG0415	Belongs to the DNA photolyase family
HA514_RS06740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HA514_RS06745	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HA514_RS06750	COG1984	allophanate hydrolase subunit 2
HA514_RS06760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HA514_RS06765	COG0372	Belongs to the citrate synthase family
HA514_RS06770	COG2009	succinate dehydrogenase
HA514_RS06775	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HA514_RS06780	COG1053	succinate dehydrogenase
HA514_RS06785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HA514_RS06790	COG0567	Dehydrogenase, E1 component
HA514_RS06795	COG0508	dehydrogenase complex catalyzes the overall conversion of
HA514_RS06800	COG0045	succinate-CoA ligase (ADP-forming) activity
HA514_RS06805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HA514_RS06810	COG2188	Transcriptional regulator
HA514_RS06815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HA514_RS06815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HA514_RS06815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS06820	COG0383	alpha-mannosidase activity
HA514_RS06825	COG1271	oxidase subunit
HA514_RS06830	COG1294	oxidase, subunit
HA514_RS06835	COG4890	Cyd operon protein YbgT
HA514_RS06840	COG3790	cyd operon protein YbgE
HA514_RS06845	COG0824	Thioesterase
HA514_RS06850	COG0811	peptide transport
HA514_RS06855	COG0848	biopolymer transport protein
HA514_RS06860	COG3064	Membrane
HA514_RS06870	COG2885	chlorophyll binding
HA514_RS06875	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HA514_RS06905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HA514_RS06910	COG3201	nicotinamide mononucleotide transporter
HA514_RS06915	COG1230	cation diffusion facilitator family transporter
HA514_RS06925	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HA514_RS06935	COG2017	converts alpha-aldose to the beta-anomer
HA514_RS06940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HA514_RS06945	COG1085	galactose-1-phosphate uridylyltransferase
HA514_RS06950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HA514_RS06955	COG1119	ATPase activity
HA514_RS06960	COG2005	Transcriptional regulator
HA514_RS06960	COG3585	molybdate ion transport
HA514_RS06970	COG0725	ABC transporter, periplasmic molybdate-binding protein
HA514_RS06975	COG4149	molybdate abc transporter
HA514_RS06985	COG0561	phosphatase activity
HA514_RS06990	COG2706	6-phosphogluconolactonase activity
HA514_RS07000	COG4677	pectinesterase activity
HA514_RS07010	COG0010	Belongs to the arginase family
HA514_RS07020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HA514_RS07025	COG2986	histidine ammonia-lyase
HA514_RS07030	COG1881	PFAM PEBP family protein
HA514_RS07035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HA514_RS07040	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HA514_RS07045	COG0156	8-amino-7-oxononanoate synthase activity
HA514_RS07050	COG2226	methyltransferase
HA514_RS07060	COG3842	ATPase activity
HA514_RS07080	COG0521	Mo-molybdopterin cofactor biosynthetic process
HA514_RS07090	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HA514_RS07095	COG0314	molybdopterin synthase activity
HA514_RS07100	COG0670	Belongs to the BI1 family
HA514_RS07105	COG0392	lysyltransferase activity
HA514_RS07110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HA514_RS07115	COG3568	Endonuclease Exonuclease Phosphatase
HA514_RS07125	COG0842	Transport permease protein
HA514_RS07130	COG0842	Transport permease protein
HA514_RS07135	COG1131	(ABC) transporter
HA514_RS07140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HA514_RS07145	COG1309	transcriptional regulator
HA514_RS07150	COG0513	Belongs to the DEAD box helicase family
HA514_RS07175	COG3121	Chaperone
HA514_RS07180	COG3539	Fimbrial protein
HA514_RS07185	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HA514_RS07195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HA514_RS07205	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HA514_RS07210	COG0668	transmembrane transport
HA514_RS07215	COG1126	abc transporter atp-binding protein
HA514_RS07220	COG0765	amino acid transport
HA514_RS07225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HA514_RS07230	COG0783	Belongs to the Dps family
HA514_RS07240	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HA514_RS07245	COG2194	sulfuric ester hydrolase activity
HA514_RS07255	COG1321	iron dependent repressor
HA514_RS07260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HA514_RS07265	COG1566	PFAM secretion protein HlyD family protein
HA514_RS07280	COG0667	Aldo Keto reductase
HA514_RS07285	COG2723	6-phospho-beta-galactosidase activity
HA514_RS07290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HA514_RS07295	COG2188	Transcriptional regulator
HA514_RS07300	COG1376	ErfK ybiS ycfS ynhG family protein
HA514_RS07305	COG0488	(ABC) transporter
HA514_RS07315	COG2271	Major facilitator Superfamily
HA514_RS07320	COG1609	Transcriptional regulator
HA514_RS07330	COG0561	phosphatase activity
HA514_RS07335	COG1882	Formate acetyltransferase
HA514_RS07340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HA514_RS07345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HA514_RS07350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HA514_RS07360	COG1446	asparaginase
HA514_RS07370	COG0747	negative chemotaxis
HA514_RS07395	COG2133	pyrroloquinoline quinone binding
HA514_RS07400	COG0625	glutathione transferase activity
HA514_RS07405	COG1686	Belongs to the peptidase S11 family
HA514_RS07410	COG1349	DNA-binding transcription factor activity
HA514_RS07415	COG0671	phosphoesterase, PA-phosphatase related
HA514_RS07425	COG2814	Major facilitator Superfamily
HA514_RS07430	COG0561	phosphatase activity
HA514_RS07435	COG0738	Major facilitator superfamily
HA514_RS07440	COG3226	Transcriptional regulator
HA514_RS07445	COG2985	domain, Protein
HA514_RS07445	COG0569	domain protein
HA514_RS07460	COG0778	Nitroreductase
HA514_RS07465	COG0189	ligase activity
HA514_RS07475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HA514_RS07480	COG3842	ATPase activity
HA514_RS07485	COG1176	ABC-type spermidine putrescine transport system, permease component I
HA514_RS07490	COG1177	transmembrane transport
HA514_RS07500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HA514_RS07505	COG0745	RESPONSE REGULATOR receiver
HA514_RS07510	COG5002	protein histidine kinase activity
HA514_RS07515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HA514_RS07520	COG4160	amino acid transport
HA514_RS07525	COG4215	(ABC) transporter
HA514_RS07530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HA514_RS07535	COG1126	abc transporter atp-binding protein
HA514_RS07545	COG0393	Putative heavy-metal-binding
HA514_RS07550	COG3023	N-Acetylmuramoyl-L-alanine amidase
HA514_RS07570	COG3031	protein transport across the cell outer membrane
HA514_RS07575	COG1450	Type ii and iii secretion system protein
HA514_RS07580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HA514_RS07585	COG1459	type II secretion system
HA514_RS07590	COG2165	general secretion pathway protein
HA514_RS07600	COG2165	general secretion pathway protein
HA514_RS07610	COG3156	type II secretion system protein K
HA514_RS07625	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HA514_RS07640	COG3397	chitin binding
HA514_RS07645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HA514_RS07650	COG0702	epimerase
HA514_RS07655	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HA514_RS07660	COG0028	Belongs to the TPP enzyme family
HA514_RS07670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HA514_RS07675	COG1151	hydroxylamine reductase activity
HA514_RS07680	COG2431	L-lysine efflux transmembrane transporter activity
HA514_RS07690	COG3593	DNA synthesis involved in DNA repair
HA514_RS07695	COG2990	Protein conserved in bacteria
HA514_RS07700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HA514_RS07710	COG1278	Cold shock
HA514_RS07715	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HA514_RS07720	COG0542	response to heat
HA514_RS07730	COG1518	maintenance of DNA repeat elements
HA514_RS07735	COG1203	CRISPR-associated helicase, Cas3
HA514_RS07760	COG5654	RES domain protein
HA514_RS07765	COG5642	Protein of unknown function (DUF2384)
HA514_RS07770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HA514_RS07775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HA514_RS07780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HA514_RS07785	COG4988	ABC transporter
HA514_RS07790	COG0492	ferredoxin-NADP+ reductase activity
HA514_RS07800	COG1178	ABC-type Fe3 transport system permease component
HA514_RS07800	COG1674	ftsk spoiiie
HA514_RS07805	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HA514_RS07810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HA514_RS07815	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HA514_RS07820	COG0243	molybdopterin cofactor binding
HA514_RS07825	COG0437	4 iron, 4 sulfur cluster binding
HA514_RS07830	COG3302	dmso reductase anchor subunit
HA514_RS07835	COG0477	Major facilitator Superfamily
HA514_RS07845	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HA514_RS07850	COG1882	Formate acetyltransferase
HA514_RS07855	COG2116	formate transmembrane transporter activity
HA514_RS07860	COG1944	ATP diphosphatase activity
HA514_RS07865	COG2323	membrane
HA514_RS07870	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HA514_RS07875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HA514_RS07880	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HA514_RS07885	COG0539	negative regulation of cytoplasmic translation
HA514_RS07890	COG0776	regulation of translation
HA514_RS07895	COG2333	competence protein COMEC
HA514_RS07895	COG0658	competence protein
HA514_RS07905	COG1663	tetraacyldisaccharide 4'-kinase activity
HA514_RS07910	COG3214	Protein conserved in bacteria
HA514_RS07915	COG2835	tetraacyldisaccharide 4'-kinase activity
HA514_RS07920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HA514_RS07925	COG3173	Aminoglycoside phosphotransferase
HA514_RS07930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HA514_RS07935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HA514_RS07945	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HA514_RS07950	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HA514_RS07955	COG2989	Protein conserved in bacteria
HA514_RS07960	COG3108	Peptidase M15
HA514_RS07965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HA514_RS07970	COG1448	Aminotransferase
HA514_RS07980	COG0017	Asparaginyl-tRNA synthetase
HA514_RS07985	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HA514_RS07990	COG0308	aminopeptidase N
HA514_RS08000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HA514_RS08005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA514_RS08010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HA514_RS08015	COG0431	NADPH-dependent FMN reductase
HA514_RS08020	COG0167	dihydroorotate dehydrogenase activity
HA514_RS08030	COG3217	Mosc domain protein beta barrel domain protein
HA514_RS08030	COG0633	Ferredoxin
HA514_RS08035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HA514_RS08035	COG0116	Belongs to the methyltransferase superfamily
HA514_RS08040	COG0488	(ABC) transporter
HA514_RS08045	COG2995	paraquat-inducible protein a
HA514_RS08050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HA514_RS08050	COG3008	intermembrane lipid transfer
HA514_RS08055	COG3009	Protein conserved in bacteria
HA514_RS08060	COG3130	regulation of translation
HA514_RS08070	COG1067	ATP-dependent peptidase activity
HA514_RS08075	COG3120	sequence-specific DNA binding
HA514_RS08085	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
HA514_RS08090	COG3070	regulator of competence-specific genes
HA514_RS08095	COG1289	transmembrane transporter activity
HA514_RS08100	COG3304	Inner membrane component domain
HA514_RS08105	COG0210	DNA helicase
HA514_RS08110	COG1803	Methylglyoxal synthase
HA514_RS08115	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HA514_RS08120	COG1832	CoA-binding protein
HA514_RS08130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HA514_RS08140	COG1881	PFAM PEBP family protein
HA514_RS08150	COG1254	Belongs to the acylphosphatase family
HA514_RS08155	COG2920	part of a sulfur-relay system
HA514_RS08195	COG0670	Belongs to the BI1 family
HA514_RS08220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HA514_RS08225	COG1696	Membrane protein involved in D-alanine export
HA514_RS08255	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HA514_RS08275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HA514_RS08280	COG3648	Uricase
HA514_RS08280	COG3195	allantoin biosynthetic process
HA514_RS08285	COG2351	hydroxyisourate hydrolase activity
HA514_RS08290	COG0402	S-adenosylhomocysteine deaminase activity
HA514_RS08295	COG1953	Uracil, thiamine, allantoin
HA514_RS08355	COG1126	abc transporter atp-binding protein
HA514_RS08360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HA514_RS08370	COG2239	Acts as a magnesium transporter
HA514_RS08395	COG3729	General stress protein
HA514_RS08405	COG2233	PERMEase
HA514_RS08410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HA514_RS08415	COG0778	Nitroreductase
HA514_RS08420	COG2267	carboxylic ester hydrolase activity
HA514_RS08425	COG0251	oxidation-reduction process
HA514_RS08430	COG1335	isochorismatase
HA514_RS08435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA514_RS08440	COG1309	transcriptional regulator
HA514_RS08450	COG0506	proline dehydrogenase activity
HA514_RS08450	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HA514_RS08450	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HA514_RS08455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HA514_RS08465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HA514_RS08475	COG2822	iron ion transport
HA514_RS08485	COG1702	phosphate starvation-inducible protein PhoH
HA514_RS08490	COG1115	amino acid carrier protein
HA514_RS08535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HA514_RS08540	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HA514_RS08545	COG3381	protein complex oligomerization
HA514_RS08595	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HA514_RS08610	COG2943	transferase activity, transferring hexosyl groups
HA514_RS08615	COG5645	(Lipo)protein
HA514_RS08655	COG1560	Kdo2-lipid A biosynthetic process
HA514_RS08665	COG2353	YceI-like domain
HA514_RS08670	COG3038	cytochrome b561
HA514_RS08695	COG0418	dihydroorotase activity
HA514_RS08705	COG0477	Major facilitator Superfamily
HA514_RS08710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HA514_RS08715	COG3132	Protein of unknown function, DUF480
HA514_RS08750	COG1558	bacterial-type flagellum-dependent cell motility
HA514_RS08755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HA514_RS08760	COG1749	Flagellar hook protein flgE
HA514_RS08765	COG4787	bacterial-type flagellum-dependent cell motility
HA514_RS08770	COG4786	Flagellar basal body rod
HA514_RS08790	COG1256	bacterial-type flagellum assembly
HA514_RS08800	COG2814	Major facilitator Superfamily
HA514_RS08805	COG0583	DNA-binding transcription factor activity
HA514_RS08810	COG1530	ribonuclease E activity
HA514_RS08815	COG0564	pseudouridine synthase activity
HA514_RS08830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HA514_RS08835	COG0416	fatty acid biosynthetic process
HA514_RS08840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HA514_RS08855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HA514_RS08860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA514_RS08885	COG3121	Chaperone
HA514_RS08895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HA514_RS08900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HA514_RS08910	COG0470	DNA polymerase III
HA514_RS08915	COG0084	hydrolase, TatD family'
HA514_RS08925	COG4773	Receptor
HA514_RS08930	COG0537	adenosine 5'-monophosphoramidase activity
HA514_RS08935	COG5633	Lipoprotein
HA514_RS08940	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HA514_RS08955	COG3150	esterase
HA514_RS08960	COG1252	NADH dehydrogenase
HA514_RS08965	COG3134	Outer membrane lipoprotein
HA514_RS08970	COG1309	transcriptional regulator
HA514_RS08980	COG1388	LysM domain
HA514_RS08980	COG1376	ErfK ybiS ycfS ynhG family protein
HA514_RS08985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HA514_RS08990	COG4763	Acyl-transferase
HA514_RS08995	COG4591	ABC-type transport system involved in lipoprotein release permease component
HA514_RS09000	COG1136	(ABC) transporter
HA514_RS09005	COG4591	ABC-type transport system involved in lipoprotein release permease component
HA514_RS09015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HA514_RS09020	COG0840	transmembrane signaling receptor activity
HA514_RS09025	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HA514_RS09055	COG1943	Transposase
HA514_RS09060	COG2850	peptidyl-arginine hydroxylation
HA514_RS09075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HA514_RS09080	COG2915	High frequency lysogenization protein hflD homolog
HA514_RS09095	COG1187	pseudouridine synthase activity
HA514_RS09100	COG0538	isocitrate dehydrogenase activity
HA514_RS09120	COG4251	negative regulation of phosphorylation
HA514_RS09120	COG5001	Diguanylate cyclase
HA514_RS09120	COG3706	GGDEF domain
HA514_RS09120	COG2203	Gaf domain
HA514_RS09125	COG2261	transglycosylase associated protein
HA514_RS09135	COG2203	Gaf domain
HA514_RS09135	COG2199	diguanylate cyclase activity
HA514_RS09140	COG3042	response to heat
HA514_RS09150	COG3189	MarR family transcriptional regulator
HA514_RS09155	COG0504	CTP synthase activity
HA514_RS09160	COG2807	transmembrane transport
HA514_RS09165	COG2207	Transcriptional regulator
HA514_RS09170	COG2707	UPF0756 membrane protein
HA514_RS09180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HA514_RS09185	COG2718	Belongs to the UPF0229 family
HA514_RS09190	COG2766	serine protein kinase
HA514_RS09195	COG3713	MltA-interacting MipA family protein
HA514_RS09215	COG3139	Protein of unknown function (DUF1315)
HA514_RS09220	COG3469	chitinase activity
HA514_RS09220	COG3325	Belongs to the glycosyl hydrolase 18 family
HA514_RS09225	COG1335	isochorismatase
HA514_RS09230	COG0252	asparaginase activity
HA514_RS09235	COG0616	signal peptide processing
HA514_RS09240	COG0778	Nitroreductase
HA514_RS09245	COG0709	Synthesizes selenophosphate from selenide and ATP
HA514_RS09250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HA514_RS09265	COG0494	nUDIX hydrolase
HA514_RS09270	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HA514_RS09275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HA514_RS09280	COG2897	thiosulfate sulfurtransferase activity
HA514_RS09285	COG4136	ATPase activity
HA514_RS09290	COG4135	transport system, permease component
HA514_RS09295	COG4134	Bacterial extracellular solute-binding protein
HA514_RS09305	COG0708	Exodeoxyribonuclease III
HA514_RS09315	COG3138	arginine N-succinyltransferase
HA514_RS09320	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS09325	COG3724	N-succinylarginine dihydrolase activity
HA514_RS09335	COG3678	ATP-independent chaperone mediated protein folding
HA514_RS09345	COG0322	excinuclease ABC activity
HA514_RS09350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HA514_RS09355	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HA514_RS09360	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HA514_RS09365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HA514_RS09370	COG1447	Phosphotransferase system cellobiose-specific component IIA
HA514_RS09375	COG1917	Cupin 2, conserved barrel domain protein
HA514_RS09375	COG2169	Transcriptional regulator
HA514_RS09380	COG1486	melibiose metabolic process
HA514_RS09385	COG3394	polysaccharide catabolic process
HA514_RS09390	COG0753	catalase activity
HA514_RS09405	COG1988	membrane-bound metal-dependent
HA514_RS09410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA514_RS09420	COG3001	Fructosamine kinase
HA514_RS09430	COG1105	Belongs to the carbohydrate kinase PfkB family
HA514_RS09435	COG3137	Salt-induced outer membrane protein
HA514_RS09475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HA514_RS09480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HA514_RS09480	COG0072	phenylalanine-tRNA ligase activity
HA514_RS09485	COG0776	regulation of translation
HA514_RS09495	COG0386	Belongs to the glutathione peroxidase family
HA514_RS09505	COG0791	NLP P60 protein
HA514_RS09540	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HA514_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS09550	COG2610	gluconate transmembrane transporter activity
HA514_RS09560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HA514_RS09565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HA514_RS09570	COG0583	DNA-binding transcription factor activity
HA514_RS09580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA514_RS09585	COG4558	Periplasmic binding protein
HA514_RS09590	COG3720	iron ion transport
HA514_RS09600	COG4256	Hemin uptake protein
HA514_RS09605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HA514_RS09610	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HA514_RS09615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HA514_RS09615	COG0574	Belongs to the PEP-utilizing enzyme family
HA514_RS09620	COG2211	Major facilitator Superfamily
HA514_RS09625	COG1472	Belongs to the glycosyl hydrolase 3 family
HA514_RS09635	COG0628	permease
HA514_RS09640	COG0277	FAD linked oxidase domain protein
HA514_RS09640	COG0247	lactate metabolic process
HA514_RS09645	COG2050	protein possibly involved in aromatic compounds catabolism
HA514_RS09655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HA514_RS09670	COG3121	Chaperone
HA514_RS09695	COG3383	formate dehydrogenase (NAD+) activity
HA514_RS09715	COG2200	EAL domain
HA514_RS09720	COG0789	Transcriptional regulator
HA514_RS09725	COG0316	Belongs to the HesB IscA family
HA514_RS09730	COG0719	Fe-S assembly protein
HA514_RS09735	COG0396	ATPase activity
HA514_RS09740	COG0719	Fe-S assembly protein
HA514_RS09745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HA514_RS09750	COG2166	iron-sulfur cluster assembly
HA514_RS09755	COG1376	ErfK ybiS ycfS ynhG family protein
HA514_RS09770	COG0626	cystathionine gamma-synthase activity
HA514_RS09785	COG2011	ABC-type metal ion transport system permease component
HA514_RS09790	COG1464	Belongs to the NlpA lipoprotein family
HA514_RS09815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HA514_RS09825	COG4529	Protein conserved in bacteria
HA514_RS09840	COG0534	Mate efflux family protein
HA514_RS09845	COG0307	riboflavin synthase, alpha
HA514_RS09850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HA514_RS09855	COG2814	Major facilitator Superfamily
HA514_RS09860	COG0583	DNA-binding transcription factor activity
HA514_RS09875	COG2814	Major facilitator Superfamily
HA514_RS09885	COG0791	NLP P60 protein
HA514_RS09890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HA514_RS09895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HA514_RS09905	COG1902	pentaerythritol trinitrate reductase activity
HA514_RS09910	COG1309	transcriptional regulator
HA514_RS09915	COG2194	sulfuric ester hydrolase activity
HA514_RS09920	COG3313	Fe-S protein
HA514_RS09925	COG4989	oxidoreductase activity
HA514_RS09930	COG2032	superoxide dismutase activity
HA514_RS09940	COG1566	PFAM secretion protein HlyD family protein
HA514_RS09955	COG3706	GGDEF domain
HA514_RS09965	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HA514_RS09970	COG3895	Periplasmic Protein
HA514_RS09975	COG0259	pyridoxamine-phosphate oxidase activity
HA514_RS09980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HA514_RS09985	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HA514_RS09990	COG0625	glutathione transferase activity
HA514_RS09995	COG3104	oligopeptide transport
HA514_RS10000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HA514_RS10010	COG4659	FMN binding
HA514_RS10040	COG3039	Transposase
HA514_RS10055	COG0673	inositol 2-dehydrogenase activity
HA514_RS10060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HA514_RS10065	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HA514_RS10070	COG1263	PTS System
HA514_RS10070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA514_RS10075	COG1609	Transcriptional regulator
HA514_RS10080	COG5339	Protein conserved in bacteria
HA514_RS10085	COG1482	cell wall glycoprotein biosynthetic process
HA514_RS10090	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HA514_RS10090	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HA514_RS10095	COG0114	fumarate hydratase activity
HA514_RS10105	COG2205	protein histidine kinase activity
HA514_RS10115	COG0745	RESPONSE REGULATOR receiver
HA514_RS10120	COG3136	membrane protein required for alginate biosynthesis
HA514_RS10125	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS10130	COG0531	amino acid
HA514_RS10140	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HA514_RS10145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HA514_RS10150	COG0668	transmembrane transport
HA514_RS10155	COG0589	response to stress
HA514_RS10175	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HA514_RS10180	COG1473	amidohydrolase
HA514_RS10190	COG0583	DNA-binding transcription factor activity
HA514_RS10195	COG2840	Smr protein MutS2
HA514_RS10205	COG0667	Aldo Keto reductase
HA514_RS10210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HA514_RS10225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HA514_RS10235	COG1403	HNH endonuclease
HA514_RS10240	COG0384	phenazine biosynthesis protein PhzF
HA514_RS10245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA514_RS10250	COG0628	permease
HA514_RS10255	COG2076	Multidrug Resistance protein
HA514_RS10260	COG2076	Multidrug Resistance protein
HA514_RS10265	COG3591	Belongs to the peptidase S1B family
HA514_RS10275	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HA514_RS10280	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HA514_RS10285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HA514_RS10290	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS10295	COG1396	sequence-specific DNA binding
HA514_RS10295	COG1917	Cupin 2, conserved barrel domain protein
HA514_RS10300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HA514_RS10305	COG0174	glutamine synthetase
HA514_RS10310	COG0531	amino acid
HA514_RS10315	COG2814	Major facilitator Superfamily
HA514_RS10320	COG0583	DNA-binding transcription factor activity
HA514_RS10325	COG1940	carbohydrate kinase activity
HA514_RS10330	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HA514_RS10375	COG0583	DNA-binding transcription factor activity
HA514_RS10385	COG3141	response to X-ray
HA514_RS10390	COG2207	Transcriptional regulator
HA514_RS10390	COG3708	Transcriptional regulator
HA514_RS10395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HA514_RS10425	COG3381	protein complex oligomerization
HA514_RS10445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HA514_RS10455	COG1742	UPF0060 membrane protein
HA514_RS10460	COG4948	Mandelate Racemase Muconate Lactonizing
HA514_RS10465	COG1063	alcohol dehydrogenase
HA514_RS10470	COG0477	Major facilitator Superfamily
HA514_RS10475	COG0246	Mannitol dehydrogenase
HA514_RS10485	COG0589	response to stress
HA514_RS10490	COG1802	Transcriptional regulator
HA514_RS10495	COG4221	oxidoreductase activity
HA514_RS10505	COG3300	MHYT domain
HA514_RS10505	COG5001	Diguanylate cyclase
HA514_RS10530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HA514_RS10535	COG2911	Protein conserved in bacteria
HA514_RS10545	COG3784	Protein of unknown function (DUF1318)
HA514_RS10550	COG2207	Transcriptional regulator
HA514_RS10555	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS10560	COG5001	Diguanylate cyclase
HA514_RS10560	COG4251	negative regulation of phosphorylation
HA514_RS10560	COG2203	Gaf domain
HA514_RS10560	COG3706	GGDEF domain
HA514_RS10570	COG2030	dehydratase
HA514_RS10570	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS10575	COG3396	Phenylacetate-CoA oxygenase
HA514_RS10580	COG3460	Phenylacetate-CoA oxygenase
HA514_RS10585	COG3396	Phenylacetate-CoA oxygenase
HA514_RS10590	COG2151	metal-sulfur cluster biosynthetic enzyme
HA514_RS10595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HA514_RS10600	COG1024	Enoyl-CoA hydratase
HA514_RS10605	COG1024	Enoyl-CoA hydratase
HA514_RS10610	COG1250	3-hydroxyacyl-CoA dehydrogenase
HA514_RS10615	COG2050	protein possibly involved in aromatic compounds catabolism
HA514_RS10620	COG0183	Belongs to the thiolase family
HA514_RS10625	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HA514_RS10630	COG3327	negative regulation of DNA-templated transcription, initiation
HA514_RS10635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HA514_RS10640	COG2207	Transcriptional regulator
HA514_RS10650	COG0583	DNA-binding transcription factor activity
HA514_RS10655	COG1408	metallophosphoesterase
HA514_RS10660	COG2814	Major facilitator Superfamily
HA514_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS10675	COG4221	oxidoreductase activity
HA514_RS10705	COG0386	Belongs to the glutathione peroxidase family
HA514_RS10715	COG0251	oxidation-reduction process
HA514_RS10720	COG1309	transcriptional regulator
HA514_RS10730	COG2807	transmembrane transport
HA514_RS10735	COG1846	Transcriptional regulator
HA514_RS10740	COG0583	DNA-binding transcription factor activity
HA514_RS10785	COG0583	DNA-binding transcription factor activity
HA514_RS10815	COG0346	lactoylglutathione lyase activity
HA514_RS10835	COG0300	oxidoreductase activity
HA514_RS10850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HA514_RS10880	COG0583	DNA-binding transcription factor activity
HA514_RS10895	COG3122	Protein conserved in bacteria
HA514_RS10910	COG1643	Atp-dependent helicase
HA514_RS10915	COG4122	O-methyltransferase activity
HA514_RS10920	COG1538	Outer membrane efflux protein
HA514_RS10935	COG0477	Major facilitator Superfamily
HA514_RS10940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HA514_RS10945	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HA514_RS10950	COG3038	cytochrome b561
HA514_RS10955	COG0673	inositol 2-dehydrogenase activity
HA514_RS10960	COG1349	DNA-binding transcription factor activity
HA514_RS10980	COG0840	transmembrane signaling receptor activity
HA514_RS10985	COG4993	Dehydrogenase
HA514_RS10990	COG0583	DNA-binding transcription factor activity
HA514_RS10995	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS11000	COG3111	PFAM Bacterial OB fold (BOF) protein
HA514_RS11015	COG1546	Belongs to the CinA family
HA514_RS11030	COG1294	oxidase, subunit
HA514_RS11035	COG1271	oxidase subunit
HA514_RS11040	COG3546	catalase activity
HA514_RS11045	COG3685	Protein conserved in bacteria
HA514_RS11055	COG3685	Protein conserved in bacteria
HA514_RS11060	COG3729	General stress protein
HA514_RS11065	COG5383	Protein conserved in bacteria
HA514_RS11070	COG2272	Belongs to the type-B carboxylesterase lipase family
HA514_RS11080	COG0436	Aminotransferase
HA514_RS11090	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HA514_RS11095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HA514_RS11100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HA514_RS11105	COG1275	C4-dicarboxylate transporter malic acid transport protein
HA514_RS11110	COG0500	methyltransferase
HA514_RS11115	COG2195	Cleaves the N-terminal amino acid of tripeptides
HA514_RS11120	COG0747	negative chemotaxis
HA514_RS11140	COG3135	benzoate transporter
HA514_RS11145	COG1396	sequence-specific DNA binding
HA514_RS11150	COG0826	peptidase U32
HA514_RS11175	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HA514_RS11195	COG1129	ABC transporter
HA514_RS11205	COG3443	Belongs to the bacterial solute-binding protein 9 family
HA514_RS11210	COG2814	Major facilitator Superfamily
HA514_RS11215	COG0697	spore germination
HA514_RS11230	COG1846	Transcriptional regulator
HA514_RS11245	COG2814	Major facilitator Superfamily
HA514_RS11265	COG0583	DNA-binding transcription factor activity
HA514_RS11270	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS11280	COG2066	Belongs to the glutaminase family
HA514_RS11290	COG2199	diguanylate cyclase activity
HA514_RS11295	COG3706	GGDEF domain
HA514_RS11305	COG0246	Mannitol dehydrogenase
HA514_RS11310	COG3781	membrane
HA514_RS11330	COG0596	Alpha beta hydrolase
HA514_RS11335	COG0745	RESPONSE REGULATOR receiver
HA514_RS11340	COG2205	protein histidine kinase activity
HA514_RS11350	COG4106	trans-aconitate 2-methyltransferase activity
HA514_RS11355	COG0494	nUDIX hydrolase
HA514_RS11360	COG1349	DNA-binding transcription factor activity
HA514_RS11375	COG3550	peptidyl-serine autophosphorylation
HA514_RS11390	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HA514_RS11400	COG0745	RESPONSE REGULATOR receiver
HA514_RS11410	COG0583	DNA-binding transcription factor activity
HA514_RS11415	COG2814	Major facilitator Superfamily
HA514_RS11450	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HA514_RS11465	COG0583	DNA-binding transcription factor activity
HA514_RS11470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HA514_RS11475	COG4628	conserved protein (DUF2132)
HA514_RS11485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HA514_RS11535	COG0840	transmembrane signaling receptor activity
HA514_RS11565	COG2200	EAL domain
HA514_RS11580	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HA514_RS11585	COG0747	negative chemotaxis
HA514_RS11590	COG0601	transmembrane transport
HA514_RS11595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HA514_RS11600	COG0444	Belongs to the ABC transporter superfamily
HA514_RS11605	COG4608	Belongs to the ABC transporter superfamily
HA514_RS11610	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS11620	COG1764	response to oxidative stress
HA514_RS11645	COG0281	malic enzyme
HA514_RS11650	COG0488	(ABC) transporter
HA514_RS11655	COG1064	alcohol dehydrogenase
HA514_RS11660	COG2814	Major facilitator Superfamily
HA514_RS11675	COG2326	polyphosphate kinase activity
HA514_RS11680	COG2864	formate dehydrogenase
HA514_RS11685	COG0437	4 iron, 4 sulfur cluster binding
HA514_RS11735	COG1473	amidohydrolase
HA514_RS11740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA514_RS11745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HA514_RS11745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HA514_RS11760	COG4772	TonB-dependent receptor
HA514_RS11765	COG1802	Transcriptional regulator
HA514_RS11770	COG2130	NADP-dependent
HA514_RS11780	COG1247	-acetyltransferase
HA514_RS11785	COG3238	Protein conserved in bacteria
HA514_RS11795	COG0747	negative chemotaxis
HA514_RS11825	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS11830	COG1177	transmembrane transport
HA514_RS11835	COG1176	ABC-type spermidine putrescine transport system, permease component I
HA514_RS11840	COG3842	ATPase activity
HA514_RS11845	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HA514_RS11850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HA514_RS11860	COG1271	oxidase subunit
HA514_RS11865	COG1294	oxidase, subunit
HA514_RS11875	COG3187	Heat shock protein
HA514_RS11880	COG3042	response to heat
HA514_RS11885	COG0674	pyruvate-flavodoxin oxidoreductase activity
HA514_RS11885	COG1013	pyruvate-flavodoxin oxidoreductase activity
HA514_RS11885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HA514_RS11885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HA514_RS11890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HA514_RS11925	COG0513	Belongs to the DEAD box helicase family
HA514_RS11950	COG3706	GGDEF domain
HA514_RS11960	COG0693	protein deglycase activity
HA514_RS11965	COG4166	transmembrane transport
HA514_RS11970	COG2866	Carboxypeptidase
HA514_RS11975	COG4948	Mandelate Racemase Muconate Lactonizing
HA514_RS11980	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HA514_RS11995	COG3768	UPF0283 membrane protein
HA514_RS12000	COG3106	COG3106 Predicted ATPase
HA514_RS12005	COG1609	Transcriptional regulator
HA514_RS12015	COG3842	ATPase activity
HA514_RS12020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA514_RS12025	COG1554	hydrolase, family 65, central catalytic
HA514_RS12030	COG0673	inositol 2-dehydrogenase activity
HA514_RS12035	COG1082	Xylose isomerase domain protein TIM barrel
HA514_RS12040	COG1063	alcohol dehydrogenase
HA514_RS12045	COG0395	ABC-type sugar transport system, permease component
HA514_RS12050	COG1175	transmembrane transport
HA514_RS12055	COG1653	transport
HA514_RS12060	COG0366	Alpha amylase catalytic
HA514_RS12070	COG1983	PspC domain protein
HA514_RS12080	COG1842	Phage shock protein A
HA514_RS12085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HA514_RS12100	COG4171	peptide transport system, permease
HA514_RS12110	COG4172	Belongs to the ABC transporter superfamily
HA514_RS12120	COG5002	protein histidine kinase activity
HA514_RS12140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HA514_RS12145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HA514_RS12150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HA514_RS12150	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HA514_RS12155	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HA514_RS12160	COG5001	Diguanylate cyclase
HA514_RS12165	COG1024	Enoyl-CoA hydratase
HA514_RS12175	COG1349	DNA-binding transcription factor activity
HA514_RS12185	COG0023	Translation Initiation Factor
HA514_RS12190	COG0284	orotidine-5'-phosphate decarboxylase activity
HA514_RS12195	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HA514_RS12200	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HA514_RS12205	COG0671	phosphoesterase, PA-phosphatase related
HA514_RS12215	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HA514_RS12245	COG0616	signal peptide processing
HA514_RS12250	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS12255	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HA514_RS12285	COG0009	L-threonylcarbamoyladenylate synthase
HA514_RS12290	COG0613	PHP domain protein
HA514_RS12305	COG0512	Glutamine amidotransferase of anthranilate synthase
HA514_RS12305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HA514_RS12315	COG0133	tryptophan synthase activity
HA514_RS12320	COG0159	tryptophan synthase activity
HA514_RS12325	COG0668	transmembrane transport
HA514_RS12330	COG1278	Cold shock
HA514_RS12350	COG1846	Transcriptional regulator
HA514_RS12380	COG2391	methyltransferase activity
HA514_RS12385	COG0425	Belongs to the sulfur carrier protein TusA family
HA514_RS12395	COG3047	cAMP biosynthetic process
HA514_RS12400	COG0727	PFAM Uncharacterised protein family (UPF0153)
HA514_RS12425	COG2350	Protein conserved in bacteria
HA514_RS12430	COG1280	lysine exporter protein (LysE YggA)
HA514_RS12445	COG3099	Belongs to the UPF0263 family
HA514_RS12450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HA514_RS12455	COG4608	Belongs to the ABC transporter superfamily
HA514_RS12460	COG0444	Belongs to the ABC transporter superfamily
HA514_RS12470	COG0601	transmembrane transport
HA514_RS12480	COG2095	MarC family integral membrane protein
HA514_RS12485	COG1454	alcohol dehydrogenase
HA514_RS12485	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS12490	COG1435	thymidine kinase activity
HA514_RS12500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HA514_RS12505	COG0745	RESPONSE REGULATOR receiver
HA514_RS12510	COG1752	Esterase of the alpha-beta hydrolase superfamily
HA514_RS12515	COG3012	SEC-C Motif Domain Protein
HA514_RS12520	COG0788	formyltetrahydrofolate deformylase activity
HA514_RS12535	COG1522	sequence-specific DNA binding
HA514_RS12540	COG0697	spore germination
HA514_RS12545	COG2181	nitrate reductase activity
HA514_RS12550	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HA514_RS12555	COG1140	nitrate reductase beta subunit
HA514_RS12560	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HA514_RS12565	COG2223	nitrite transmembrane transporter activity
HA514_RS12570	COG3850	Histidine kinase
HA514_RS12575	COG2197	response regulator
HA514_RS12580	COG4932	domain protein
HA514_RS12585	COG0243	molybdopterin cofactor binding
HA514_RS12590	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HA514_RS12590	COG2146	nitrite reductase [NAD(P)H] activity
HA514_RS12595	COG1116	anion transmembrane transporter activity
HA514_RS12605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HA514_RS12610	COG3707	response regulator
HA514_RS12615	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HA514_RS12620	COG0840	transmembrane signaling receptor activity
HA514_RS12630	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HA514_RS12635	COG4572	Cation transport regulator
HA514_RS12640	COG0387	Pfam Sodium calcium exchanger
HA514_RS12645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HA514_RS12655	COG2890	protein-(glutamine-N5) methyltransferase activity
HA514_RS12665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HA514_RS12670	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HA514_RS12675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HA514_RS12685	COG0659	secondary active sulfate transmembrane transporter activity
HA514_RS12700	COG0193	aminoacyl-tRNA hydrolase activity
HA514_RS12705	COG0012	GTP binding
HA514_RS12715	COG3209	COG3209 Rhs family protein
HA514_RS12735	COG3501	Rhs element vgr protein
HA514_RS12755	COG0515	serine threonine protein kinase
HA514_RS12870	COG0243	molybdopterin cofactor binding
HA514_RS12875	COG0583	DNA-binding transcription factor activity
HA514_RS12890	COG4977	sequence-specific DNA binding
HA514_RS12900	COG2814	Major facilitator Superfamily
HA514_RS12920	COG4774	siderophore transport
HA514_RS12935	COG0741	lytic transglycosylase activity
HA514_RS12940	COG1619	proteins homologs of microcin C7 resistance protein MccF
HA514_RS12945	COG3263	regulation of cellular component size
HA514_RS12950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HA514_RS12955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HA514_RS12960	COG2719	SpoVR family
HA514_RS12970	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HA514_RS12985	COG0179	Fumarylacetoacetate (FAA) hydrolase
HA514_RS12990	COG3100	YcgL domain-containing protein
HA514_RS12995	COG0850	regulation of cytokinetic process
HA514_RS13000	COG2894	cell division
HA514_RS13005	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HA514_RS13010	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HA514_RS13015	COG0318	PFAM AMP-dependent synthetase and ligase
HA514_RS13020	COG3065	identical protein binding
HA514_RS13025	COG1214	PFAM Peptidase M22, glycoprotease
HA514_RS13030	COG1199	ATP-dependent helicase activity
HA514_RS13035	COG0251	oxidation-reduction process
HA514_RS13050	COG0494	nUDIX hydrolase
HA514_RS13055	COG1760	l-serine dehydratase
HA514_RS13060	COG2200	EAL domain
HA514_RS13065	COG1253	flavin adenine dinucleotide binding
HA514_RS13070	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS13070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA514_RS13075	COG3715	PTS system
HA514_RS13080	COG3716	PTS system mannose fructose sorbose family IID component
HA514_RS13085	COG4811	Protein of unknown function (DUF986)
HA514_RS13090	COG1971	Probably functions as a manganese efflux pump
HA514_RS13095	COG2226	methyltransferase
HA514_RS13100	COG0768	penicillin binding
HA514_RS13130	COG1414	Transcriptional regulator
HA514_RS13140	COG0501	Belongs to the peptidase M48B family
HA514_RS13155	COG1956	GAF domain-containing protein
HA514_RS13160	COG2995	paraquat-inducible protein a
HA514_RS13165	COG3008	intermembrane lipid transfer
HA514_RS13170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HA514_RS13170	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HA514_RS13185	COG2990	Protein conserved in bacteria
HA514_RS13200	COG1276	copper resistance
HA514_RS13205	COG2372	response to copper ion
HA514_RS13215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HA514_RS13220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HA514_RS13225	COG1770	oligopeptidase
HA514_RS13230	COG2979	Protein of unknown function (DUF533)
HA514_RS13240	COG0800	Aldolase
HA514_RS13245	COG0129	dihydroxy-acid dehydratase activity
HA514_RS13250	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HA514_RS13255	COG1737	Transcriptional regulator
HA514_RS13265	COG1560	Kdo2-lipid A biosynthetic process
HA514_RS13270	COG0739	heme binding
HA514_RS13275	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HA514_RS13285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HA514_RS13295	COG2255	four-way junction helicase activity
HA514_RS13300	COG0632	four-way junction helicase activity
HA514_RS13315	COG0494	nUDIX hydrolase
HA514_RS13325	COG1335	isochorismatase
HA514_RS13330	COG1801	Protein of unknown function DUF72
HA514_RS13335	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HA514_RS13340	COG2226	methyltransferase
HA514_RS13345	COG0500	methyltransferase
HA514_RS13350	COG3142	Participates in the control of copper homeostasis
HA514_RS13355	COG3102	Protein conserved in bacteria
HA514_RS13360	COG0018	arginyl-trna synthetase
HA514_RS13365	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HA514_RS13395	COG3121	Chaperone
HA514_RS13400	COG3188	usher protein
HA514_RS13415	COG0745	RESPONSE REGULATOR receiver
HA514_RS13430	COG0840	transmembrane signaling receptor activity
HA514_RS13465	COG1301	dicarboxylic acid transport
HA514_RS13505	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HA514_RS13515	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA514_RS13525	COG1879	ABC-type sugar transport system periplasmic component
HA514_RS13530	COG1528	Iron-storage protein
HA514_RS13535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HA514_RS13555	COG1528	Iron-storage protein
HA514_RS13585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HA514_RS13595	COG3012	SEC-C Motif Domain Protein
HA514_RS13595	COG3318	Belongs to the UPF0149 family
HA514_RS13645	COG3596	GTP binding
HA514_RS13890	COG3179	chitinase
HA514_RS13910	COG1403	HNH endonuclease
HA514_RS13925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HA514_RS13965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HA514_RS14050	COG2197	response regulator
HA514_RS14060	COG2197	response regulator
HA514_RS14095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HA514_RS14100	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HA514_RS14105	COG1516	flagellar protein fliS
HA514_RS14115	COG0366	Alpha amylase catalytic
HA514_RS14155	COG1677	Flagellar hook-basal body complex protein FliE
HA514_RS14165	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HA514_RS14175	COG1157	protein secretion by the type III secretion system
HA514_RS14215	COG1987	bacterial-type flagellum assembly
HA514_RS14225	COG2197	response regulator
HA514_RS14250	COG5475	Uncharacterized small protein (DUF2158)
HA514_RS14255	COG2354	Protein conserved in bacteria
HA514_RS14260	COG0697	spore germination
HA514_RS14265	COG3727	T/G mismatch-specific endonuclease activity
HA514_RS14270	COG0270	DNA (cytosine-5-)-methyltransferase activity
HA514_RS14275	COG1418	mRNA catabolic process
HA514_RS14280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HA514_RS14290	COG3290	protein histidine kinase activity
HA514_RS14295	COG4565	transcriptional regulatory protein
HA514_RS14315	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HA514_RS14315	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HA514_RS14320	COG0583	DNA-binding transcription factor activity
HA514_RS14350	COG3121	Chaperone
HA514_RS14355	COG3539	Fimbrial protein
HA514_RS14380	COG0583	DNA-binding transcription factor activity
HA514_RS14385	COG3046	protein related to deoxyribodipyrimidine photolyase
HA514_RS14435	COG0582	viral genome integration into host DNA
HA514_RS14560	COG2916	Histone family protein nucleoid-structuring protein H-NS
HA514_RS14595	COG0583	DNA-binding transcription factor activity
HA514_RS14610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HA514_RS14625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA514_RS14640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HA514_RS14645	COG0475	glutathione-regulated potassium exporter activity
HA514_RS14650	COG2814	Major facilitator Superfamily
HA514_RS14680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HA514_RS14685	COG0589	response to stress
HA514_RS14695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HA514_RS14710	COG0477	Major facilitator Superfamily
HA514_RS14715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HA514_RS14720	COG0006	proline dipeptidase activity
HA514_RS14730	COG0534	Mate efflux family protein
HA514_RS14745	COG1289	transmembrane transporter activity
HA514_RS14750	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HA514_RS14760	COG2925	Exonuclease
HA514_RS14765	COG0531	amino acid
HA514_RS14775	COG0583	DNA-binding transcription factor activity
HA514_RS14780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HA514_RS14790	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HA514_RS14800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HA514_RS14805	COG0131	Imidazoleglycerol-phosphate dehydratase
HA514_RS14805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HA514_RS14810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HA514_RS14815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HA514_RS14820	COG0107	imidazoleglycerol-phosphate synthase activity
HA514_RS14865	COG0438	transferase activity, transferring glycosyl groups
HA514_RS14885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HA514_RS14890	COG1091	dTDP-4-dehydrorhamnose reductase activity
HA514_RS14895	COG1088	dTDP-glucose 4,6-dehydratase activity
HA514_RS14910	COG0438	transferase activity, transferring glycosyl groups
HA514_RS14915	COG2327	Polysaccharide pyruvyl transferase
HA514_RS14920	COG2244	polysaccharide biosynthetic process
HA514_RS14925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HA514_RS14930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HA514_RS14940	COG0297	glycogen (starch) synthase activity
HA514_RS14945	COG1051	belongs to the nudix hydrolase family
HA514_RS14950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HA514_RS14955	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HA514_RS14960	COG0110	maltose O-acetyltransferase activity
HA514_RS14965	COG1216	Glycosyl transferase, family 2
HA514_RS14975	COG0438	transferase activity, transferring glycosyl groups
HA514_RS14980	COG1045	serine acetyltransferase
HA514_RS14985	COG0463	Glycosyl transferase, family 2
HA514_RS14990	COG3206	protein involved in exopolysaccharide biosynthesis
HA514_RS14990	COG0489	protein tyrosine kinase activity
HA514_RS15005	COG1253	flavin adenine dinucleotide binding
HA514_RS15010	COG2982	Protein involved in outer membrane biogenesis
HA514_RS15015	COG0717	Belongs to the dCTP deaminase family
HA514_RS15025	COG5001	Diguanylate cyclase
HA514_RS15025	COG5002	protein histidine kinase activity
HA514_RS15025	COG3447	MASE1 domain protein
HA514_RS15030	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HA514_RS15035	COG0443	Heat shock 70 kDa protein
HA514_RS15040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HA514_RS15045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HA514_RS15050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HA514_RS15055	COG0477	Major facilitator Superfamily
HA514_RS15060	COG2205	protein histidine kinase activity
HA514_RS15065	COG0745	RESPONSE REGULATOR receiver
HA514_RS15080	COG1597	lipid kinase activity
HA514_RS15085	COG1830	Aldolase
HA514_RS15090	COG2211	Major facilitator Superfamily
HA514_RS15095	COG1397	ADP-ribosylglycohydrolase
HA514_RS15100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA514_RS15105	COG2188	Transcriptional regulator
HA514_RS15110	COG0351	phosphomethylpyrimidine kinase
HA514_RS15115	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HA514_RS15150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HA514_RS15155	COG0076	glutamate decarboxylase activity
HA514_RS15160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HA514_RS15165	COG0489	protein tyrosine kinase activity
HA514_RS15165	COG3206	protein involved in exopolysaccharide biosynthesis
HA514_RS15170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HA514_RS15175	COG1596	polysaccharide export
HA514_RS15180	COG5455	response to cobalt ion
HA514_RS15190	COG0489	protein tyrosine kinase activity
HA514_RS15200	COG4807	Protein conserved in bacteria
HA514_RS15210	COG3275	phosphorelay sensor kinase activity
HA514_RS15215	COG0789	Transcriptional regulator
HA514_RS15225	COG1174	glycine betaine transport
HA514_RS15230	COG1125	glycine betaine transport
HA514_RS15235	COG1174	glycine betaine transport
HA514_RS15240	COG1732	Glycine betaine
HA514_RS15245	COG1472	Belongs to the glycosyl hydrolase 3 family
HA514_RS15250	COG0277	FAD linked oxidase domain protein
HA514_RS15260	COG1686	Belongs to the peptidase S11 family
HA514_RS15270	COG0586	Pfam SNARE associated Golgi protein
HA514_RS15275	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS15280	COG1538	Outer membrane efflux protein
HA514_RS15285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HA514_RS15295	COG1346	cytolysis
HA514_RS15300	COG0295	cytidine deaminase activity
HA514_RS15305	COG2949	membrane
HA514_RS15325	COG1129	ABC transporter
HA514_RS15340	COG2311	Membrane
HA514_RS15350	COG0477	Major facilitator Superfamily
HA514_RS15360	COG4771	TonB-dependent receptor
HA514_RS15365	COG0833	amino acid
HA514_RS15370	COG0583	DNA-binding transcription factor activity
HA514_RS15375	COG2855	membrane
HA514_RS15380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HA514_RS15385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HA514_RS15385	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HA514_RS15385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HA514_RS15390	COG1105	Belongs to the carbohydrate kinase PfkB family
HA514_RS15410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HA514_RS15415	COG1312	Catalyzes the dehydration of D-mannonate
HA514_RS15420	COG0246	Mannitol dehydrogenase
HA514_RS15425	COG0523	cobalamin synthesis protein
HA514_RS15430	COG0671	phosphoesterase, PA-phosphatase related
HA514_RS15435	COG0791	NLP P60 protein
HA514_RS15440	COG2200	EAL domain
HA514_RS15445	COG4166	transmembrane transport
HA514_RS15450	COG4174	ABC transporter (Permease)
HA514_RS15455	COG4239	(ABC) transporter, permease
HA514_RS15460	COG4172	Belongs to the ABC transporter superfamily
HA514_RS15470	COG2814	Major facilitator Superfamily
HA514_RS15475	COG1187	pseudouridine synthase activity
HA514_RS15480	COG1061	Type III restriction enzyme res subunit
HA514_RS15490	COG3081	Nucleoid-associated protein
HA514_RS15495	COG3082	Protein of unknown function (DUF1414)
HA514_RS15510	COG3182	Iron-regulated membrane protein
HA514_RS15520	COG0579	oxidoreductase
HA514_RS15525	COG0659	secondary active sulfate transmembrane transporter activity
HA514_RS15530	COG2239	Acts as a magnesium transporter
HA514_RS15535	COG4615	Cyclic peptide transporter
HA514_RS15540	COG3145	DNA-N1-methyladenine dioxygenase activity
HA514_RS15545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HA514_RS15545	COG2169	Transcriptional regulator
HA514_RS15550	COG1477	protein flavinylation
HA514_RS15560	COG0642	Histidine kinase
HA514_RS15560	COG2198	Histidine kinase
HA514_RS15580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HA514_RS15595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HA514_RS15600	COG0584	glycerophosphoryl diester phosphodiesterase
HA514_RS15605	COG2271	Major facilitator Superfamily
HA514_RS15610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HA514_RS15615	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
HA514_RS15620	COG0247	lactate metabolic process
HA514_RS15635	COG2205	protein histidine kinase activity
HA514_RS15665	COG1441	menaquinone biosynthetic process
HA514_RS15675	COG0596	Alpha beta hydrolase
HA514_RS15680	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HA514_RS15685	COG1169	isochorismate synthase
HA514_RS15690	COG4575	ribosome binding
HA514_RS15695	COG2153	protein acetylation
HA514_RS15700	COG1234	tRNA 3'-trailer cleavage
HA514_RS15705	COG0835	chemotaxis
HA514_RS15705	COG0784	Response regulator, receiver
HA514_RS15710	COG1007	ATP synthesis coupled electron transport
HA514_RS15715	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HA514_RS15720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HA514_RS15725	COG0713	ATP synthesis coupled electron transport
HA514_RS15730	COG0839	Belongs to the complex I subunit 6 family
HA514_RS15740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HA514_RS15770	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HA514_RS15775	COG0583	DNA-binding transcription factor activity
HA514_RS15780	COG0436	Aminotransferase
HA514_RS15790	COG0471	metal ion transport
HA514_RS15790	COG0490	domain, Protein
HA514_RS15795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA514_RS15820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HA514_RS15825	COG3959	Transketolase, thiamine diphosphate binding domain
HA514_RS15830	COG3037	sugar-specific permease SgaT UlaA
HA514_RS15840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS15845	COG1609	Transcriptional regulator
HA514_RS15855	COG0622	Phosphoesterase
HA514_RS15860	COG0625	glutathione transferase activity
HA514_RS15865	COG0625	glutathione transferase activity
HA514_RS15870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HA514_RS15875	COG1090	epimerase
HA514_RS15880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HA514_RS15885	COG4598	ABC transporter
HA514_RS15890	COG4160	amino acid transport
HA514_RS15900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HA514_RS15910	COG0163	prenyltransferase activity
HA514_RS15915	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HA514_RS15920	COG1286	toxin biosynthetic process
HA514_RS15925	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HA514_RS15930	COG0285	dihydrofolate synthase activity
HA514_RS15940	COG0586	Pfam SNARE associated Golgi protein
HA514_RS15945	COG0101	tRNA pseudouridine synthase activity
HA514_RS15950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HA514_RS15955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HA514_RS15970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HA514_RS15975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HA514_RS15975	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HA514_RS15985	COG3101	peptidyl-lysine hydroxylation
HA514_RS15990	COG0730	response to heat
HA514_RS16000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HA514_RS16010	COG2840	Smr protein MutS2
HA514_RS16015	COG2062	phosphohistidine phosphatase, SixA
HA514_RS16020	COG1024	Enoyl-CoA hydratase
HA514_RS16020	COG1250	3-hydroxyacyl-CoA dehydrogenase
HA514_RS16030	COG3691	Protein conserved in bacteria
HA514_RS16035	COG2067	long-chain fatty acid transport protein
HA514_RS16045	COG2116	formate transmembrane transporter activity
HA514_RS16060	COG0582	viral genome integration into host DNA
HA514_RS16080	COG4974	Belongs to the 'phage' integrase family
HA514_RS16170	COG2963	transposase activity
HA514_RS16175	COG1609	Transcriptional regulator
HA514_RS16185	COG2223	nitrite transmembrane transporter activity
HA514_RS16220	COG0071	Belongs to the small heat shock protein (HSP20) family
HA514_RS16225	COG0542	response to heat
HA514_RS16240	COG0501	Belongs to the peptidase M48B family
HA514_RS16270	COG1560	Kdo2-lipid A biosynthetic process
HA514_RS16280	COG0436	Aminotransferase
HA514_RS16285	COG3275	phosphorelay sensor kinase activity
HA514_RS16290	COG3279	Response regulator of the LytR AlgR family
HA514_RS16295	COG0837	glucose binding
HA514_RS16305	COG3961	Belongs to the TPP enzyme family
HA514_RS16310	COG0667	Aldo Keto reductase
HA514_RS16320	COG1914	H( )-stimulated, divalent metal cation uptake system
HA514_RS16325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HA514_RS16330	COG2200	EAL domain
HA514_RS16330	COG2199	diguanylate cyclase activity
HA514_RS16345	COG3415	Transposase
HA514_RS16350	COG3415	Transposase
HA514_RS16355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HA514_RS16380	COG0583	DNA-binding transcription factor activity
HA514_RS16385	COG2211	Major facilitator Superfamily
HA514_RS16390	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HA514_RS16400	COG0583	DNA-binding transcription factor activity
HA514_RS16405	COG0385	Bile acid
HA514_RS16410	COG3530	Putative quorum-sensing-regulated virulence factor
HA514_RS16415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HA514_RS16420	COG3115	cell septum assembly
HA514_RS16440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS16465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HA514_RS16470	COG4208	sulfate ABC transporter
HA514_RS16475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HA514_RS16480	COG4150	thiosulfate binding
HA514_RS16485	COG2837	iron assimilation
HA514_RS16505	COG0860	N-Acetylmuramoyl-L-alanine amidase
HA514_RS16510	COG0408	coproporphyrinogen oxidase activity
HA514_RS16525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HA514_RS16530	COG5342	invasion associated locus B
HA514_RS16535	COG0494	nUDIX hydrolase
HA514_RS16540	COG3850	Histidine kinase
HA514_RS16545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HA514_RS16555	COG1393	Belongs to the ArsC family
HA514_RS16560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HA514_RS16570	COG0400	carboxylic ester hydrolase activity
HA514_RS16580	COG2321	neutral zinc metallopeptidase
HA514_RS16590	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HA514_RS16600	COG2716	regulation of RNA biosynthetic process
HA514_RS16605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HA514_RS16610	COG0628	permease
HA514_RS16615	COG4783	chaperone-mediated protein folding
HA514_RS16620	COG1393	Belongs to the ArsC family
HA514_RS16630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HA514_RS16635	COG1446	asparaginase
HA514_RS16640	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HA514_RS16650	COG2233	PERMEase
HA514_RS16655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HA514_RS16660	COG2723	6-phospho-beta-galactosidase activity
HA514_RS16665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HA514_RS16670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HA514_RS16685	COG2200	EAL domain
HA514_RS16695	COG0583	DNA-binding transcription factor activity
HA514_RS16715	COG3718	enzyme involved in inositol metabolism
HA514_RS16725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA514_RS16735	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA514_RS16750	COG0673	inositol 2-dehydrogenase activity
HA514_RS16755	COG3962	Belongs to the TPP enzyme family
HA514_RS16780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HA514_RS16790	COG1061	Type III restriction enzyme res subunit
HA514_RS16835	COG3093	addiction module antidote protein HigA
HA514_RS16840	COG3846	protein secretion by the type IV secretion system
HA514_RS16885	COG0582	viral genome integration into host DNA
HA514_RS16895	COG0517	IMP dehydrogenase activity
HA514_RS16895	COG0516	GMP reductase activity
HA514_RS16900	COG1570	exodeoxyribonuclease VII activity
HA514_RS16915	COG1645	bacterial-type flagellum-dependent swarming motility
HA514_RS16925	COG3104	oligopeptide transport
HA514_RS16930	COG1160	GTP binding
HA514_RS16940	COG2976	Protein conserved in bacteria
HA514_RS16945	COG0124	histidyl-tRNA synthetase
HA514_RS16960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HA514_RS16980	COG0437	4 iron, 4 sulfur cluster binding
HA514_RS16985	COG0243	molybdopterin cofactor binding
HA514_RS16990	COG4953	penicillin-binding protein 1C
HA514_RS16995	COG2373	Large extracellular alpha-helical protein
HA514_RS17000	COG1263	PTS System
HA514_RS17000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA514_RS17000	COG2190	(PTS) system
HA514_RS17010	COG2897	thiosulfate sulfurtransferase activity
HA514_RS17015	COG1737	Transcriptional regulator
HA514_RS17025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HA514_RS17030	COG2975	iron-sulfur cluster assembly
HA514_RS17035	COG0633	Ferredoxin
HA514_RS17040	COG0443	Heat shock 70 kDa protein
HA514_RS17045	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HA514_RS17050	COG0316	Belongs to the HesB IscA family
HA514_RS17055	COG0822	iron-sulfur transferase activity
HA514_RS17060	COG1104	cysteine desulfurase activity
HA514_RS17065	COG1959	2 iron, 2 sulfur cluster binding
HA514_RS17080	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HA514_RS17090	COG3711	transcriptional antiterminator
HA514_RS17095	COG2814	Major facilitator Superfamily
HA514_RS17100	COG2259	Doxx family
HA514_RS17110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HA514_RS17110	COG1017	nitric oxide dioxygenase activity
HA514_RS17115	COG0347	Belongs to the P(II) protein family
HA514_RS17120	COG2204	response regulator
HA514_RS17125	COG3170	Tfp pilus assembly protein FimV
HA514_RS17130	COG2205	protein histidine kinase activity
HA514_RS17135	COG0047	phosphoribosylformylglycinamidine synthase activity
HA514_RS17135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HA514_RS17140	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HA514_RS17150	COG0560	Phosphoserine phosphatase
HA514_RS17155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA514_RS17155	COG1263	PTS System
HA514_RS17160	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HA514_RS17165	COG1737	Transcriptional regulator
HA514_RS17170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HA514_RS17180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HA514_RS17185	COG1381	Involved in DNA repair and RecF pathway recombination
HA514_RS17190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HA514_RS17200	COG0681	Belongs to the peptidase S26 family
HA514_RS17210	COG3086	response to oxidative stress
HA514_RS17220	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HA514_RS17235	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HA514_RS17240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HA514_RS17245	COG0513	Belongs to the DEAD box helicase family
HA514_RS17255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HA514_RS17260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HA514_RS17265	COG3118	belongs to the thioredoxin family
HA514_RS17280	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HA514_RS17285	COG5544	Lipoprotein
HA514_RS17290	COG0477	Major facilitator Superfamily
HA514_RS17315	COG0542	response to heat
HA514_RS17330	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HA514_RS17335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HA514_RS17345	COG1605	Chorismate mutase
HA514_RS17345	COG0077	Prephenate dehydratase
HA514_RS17355	COG1605	Chorismate mutase
HA514_RS17355	COG0287	Prephenate dehydrogenase
HA514_RS17360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HA514_RS17375	COG2199	diguanylate cyclase activity
HA514_RS17380	COG2885	chlorophyll binding
HA514_RS17405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HA514_RS17415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HA514_RS17420	COG4137	Cytochrome C assembly protein
HA514_RS17425	COG4536	flavin adenine dinucleotide binding
HA514_RS17430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HA514_RS17435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HA514_RS17440	COG0497	DNA recombination
HA514_RS17455	COG2867	negative regulation of translational initiation
HA514_RS17560	COG0740	serine-type endopeptidase activity
HA514_RS17565	COG4695	Portal protein
HA514_RS17570	COG1802	Transcriptional regulator
HA514_RS17570	COG4626	Terminase
HA514_RS17635	COG0484	heat shock protein binding
HA514_RS17645	COG1484	DNA-dependent DNA replication
HA514_RS17650	COG1802	Transcriptional regulator
HA514_RS17650	COG4626	Terminase
HA514_RS17725	COG0582	viral genome integration into host DNA
HA514_RS17785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HA514_RS17790	COG1051	belongs to the nudix hydrolase family
HA514_RS17805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HA514_RS17820	COG2226	methyltransferase
HA514_RS17825	COG0402	S-adenosylhomocysteine deaminase activity
HA514_RS17830	COG0549	Belongs to the carbamate kinase family
HA514_RS17840	COG1304	FMN binding
HA514_RS17845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HA514_RS17850	COG0666	response to abiotic stimulus
HA514_RS17855	COG0583	DNA-binding transcription factor activity
HA514_RS17860	COG0401	homolog of Blt101
HA514_RS17865	COG0640	Transcriptional regulator
HA514_RS17870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HA514_RS17895	COG4575	ribosome binding
HA514_RS17905	COG1780	Probably involved in ribonucleotide reductase function
HA514_RS17925	COG4176	ABC-type proline glycine betaine transport system permease component
HA514_RS17935	COG2814	Major facilitator Superfamily
HA514_RS17940	COG1846	Transcriptional regulator
HA514_RS17945	COG1566	PFAM secretion protein HlyD family protein
HA514_RS17950	COG2814	Major facilitator Superfamily
HA514_RS17955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HA514_RS17970	COG2918	glutathione biosynthetic process
HA514_RS17975	COG1238	metal cluster binding
HA514_RS17980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA514_RS18010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HA514_RS18015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HA514_RS18025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HA514_RS18030	COG1546	Belongs to the CinA family
HA514_RS18040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HA514_RS18050	COG2951	lytic endotransglycosylase activity
HA514_RS18055	COG3730	PTS system glucitol sorbitol-specific
HA514_RS18060	COG3732	PTS system glucitol sorbitol-specific
HA514_RS18070	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS18075	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS18080	COG1349	DNA-binding transcription factor activity
HA514_RS18090	COG3604	Transcriptional regulator
HA514_RS18095	COG1773	rubredoxin
HA514_RS18095	COG0426	domain, Protein
HA514_RS18100	COG0446	pyridine nucleotide-disulphide oxidoreductase
HA514_RS18105	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HA514_RS18110	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HA514_RS18115	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HA514_RS18120	COG1609	Transcriptional regulator
HA514_RS18125	COG1263	PTS System
HA514_RS18125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA514_RS18130	COG2723	6-phospho-beta-galactosidase activity
HA514_RS18135	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HA514_RS18145	COG3260	NADH ubiquinone oxidoreductase 20
HA514_RS18150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HA514_RS18155	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HA514_RS18155	COG3261	NADH dehydrogenase
HA514_RS18160	COG0650	Formate hydrogenlyase subunit 4
HA514_RS18165	COG0651	ATP synthesis coupled electron transport
HA514_RS18170	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HA514_RS18180	COG0375	protein maturation
HA514_RS18185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HA514_RS18190	COG0298	carbon dioxide binding
HA514_RS18195	COG0409	Hydrogenase expression formation protein
HA514_RS18200	COG0309	Hydrogenase expression formation protein (HypE)
HA514_RS18215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA514_RS18220	COG1120	ATPase activity
HA514_RS18240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HA514_RS18250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HA514_RS18255	COG0163	prenyltransferase activity
HA514_RS18285	COG4942	peptidase
HA514_RS18285	COG1388	LysM domain
HA514_RS18300	COG0585	pseudouridine synthase activity
HA514_RS18310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HA514_RS18315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HA514_RS18325	COG0529	Catalyzes the synthesis of activated sulfate
HA514_RS18345	COG2234	aminopeptidase activity
HA514_RS18350	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HA514_RS18355	COG1518	maintenance of DNA repeat elements
HA514_RS18385	COG1203	CRISPR-associated helicase, Cas3
HA514_RS18400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HA514_RS18405	COG0720	synthase
HA514_RS18410	COG0602	queuosine metabolic process
HA514_RS18415	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HA514_RS18420	COG1263	PTS System
HA514_RS18420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HA514_RS18420	COG2190	(PTS) system
HA514_RS18425	COG1737	Transcriptional regulator
HA514_RS18445	COG3956	TIGRFAM MazG family protein
HA514_RS18450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HA514_RS18455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HA514_RS18460	COG4999	Histidine kinase
HA514_RS18460	COG2205	protein histidine kinase activity
HA514_RS18460	COG3437	response regulator, receiver
HA514_RS18460	COG3850	Histidine kinase
HA514_RS18465	COG1929	Belongs to the glycerate kinase type-1 family
HA514_RS18470	COG4948	Mandelate Racemase Muconate Lactonizing
HA514_RS18475	COG4948	Mandelate Racemase Muconate Lactonizing
HA514_RS18480	COG2271	Major facilitator Superfamily
HA514_RS18515	COG0564	pseudouridine synthase activity
HA514_RS18520	COG3098	single-species biofilm formation
HA514_RS18535	COG1611	Belongs to the LOG family
HA514_RS18540	COG0814	amino acid
HA514_RS18545	COG1760	l-serine dehydratase
HA514_RS18555	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
HA514_RS18560	COG2363	Small membrane protein
HA514_RS18565	COG0583	DNA-binding transcription factor activity
HA514_RS18575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HA514_RS18580	COG2166	iron-sulfur cluster assembly
HA514_RS18585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HA514_RS18590	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HA514_RS18605	COG0860	N-Acetylmuramoyl-L-alanine amidase
HA514_RS18610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HA514_RS18610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HA514_RS18615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HA514_RS18620	COG1074	ATP-dependent DNA helicase activity
HA514_RS18630	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HA514_RS18635	COG4967	type IV pilus modification protein PilV
HA514_RS18645	COG4795	General secretion pathway protein
HA514_RS18650	COG2165	general secretion pathway protein
HA514_RS18655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HA514_RS18660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HA514_RS18670	COG0494	nUDIX hydrolase
HA514_RS18675	COG3066	DNA modification
HA514_RS18685	COG0667	Aldo Keto reductase
HA514_RS18690	COG0477	Major facilitator Superfamily
HA514_RS18695	COG0204	Acyl-transferase
HA514_RS18695	COG0318	PFAM AMP-dependent synthetase and ligase
HA514_RS18700	COG1609	Transcriptional regulator
HA514_RS18710	COG1609	Transcriptional regulator
HA514_RS18720	COG0583	DNA-binding transcription factor activity
HA514_RS18725	COG1794	racemase activity, acting on amino acids and derivatives
HA514_RS18730	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HA514_RS18735	COG2814	Major facilitator Superfamily
HA514_RS18740	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS18750	COG0183	Belongs to the thiolase family
HA514_RS18765	COG0814	amino acid
HA514_RS18770	COG2388	GCN5-related N-acetyl-transferase
HA514_RS18775	COG3592	Divergent 4Fe-4S mono-cluster
HA514_RS18785	COG4565	transcriptional regulatory protein
HA514_RS18795	COG4208	sulfate ABC transporter
HA514_RS18800	COG3842	ATPase activity
HA514_RS18810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HA514_RS18860	COG4942	peptidase
HA514_RS18865	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HA514_RS18870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HA514_RS18880	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HA514_RS18890	COG4974	Belongs to the 'phage' integrase family
HA514_RS18905	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HA514_RS18910	COG0354	folic acid binding
HA514_RS18915	COG1272	protein, Hemolysin III
HA514_RS18920	COG1737	Transcriptional regulator
HA514_RS18925	COG2723	6-phospho-beta-galactosidase activity
HA514_RS18930	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS18935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HA514_RS18935	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HA514_RS18945	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HA514_RS18950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HA514_RS18955	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HA514_RS18960	COG0006	proline dipeptidase activity
HA514_RS18970	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HA514_RS18980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HA514_RS18985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HA514_RS18990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HA514_RS18995	COG0583	DNA-binding transcription factor activity
HA514_RS19000	COG2968	Membrane
HA514_RS19005	COG1279	arginine transmembrane transporter activity
HA514_RS19010	COG0668	transmembrane transport
HA514_RS19015	COG0191	fructose-bisphosphate aldolase activity
HA514_RS19025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HA514_RS19030	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HA514_RS19035	COG0501	Belongs to the peptidase M48B family
HA514_RS19055	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HA514_RS19060	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS19065	COG2267	carboxylic ester hydrolase activity
HA514_RS19075	COG2814	Major facilitator Superfamily
HA514_RS19090	COG1414	Transcriptional regulator
HA514_RS19095	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS19110	COG2146	nitrite reductase [NAD(P)H] activity
HA514_RS19130	COG3121	Chaperone
HA514_RS19135	COG3188	usher protein
HA514_RS19150	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
HA514_RS19150	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
HA514_RS19150	COG3210	domain, Protein
HA514_RS19150	COG3064	Membrane
HA514_RS19150	COG3064	Membrane
HA514_RS19150	COG3210	domain, Protein
HA514_RS19155	COG1166	arginine decarboxylase activity
HA514_RS19185	COG2814	Major facilitator Superfamily
HA514_RS19190	COG3091	SprT-like family
HA514_RS19195	COG2356	endonuclease I
HA514_RS19200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HA514_RS19220	COG2805	Type II/IV secretion system protein
HA514_RS19225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HA514_RS19230	COG0762	integral membrane protein
HA514_RS19235	COG1872	DUF167
HA514_RS19245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HA514_RS19250	COG2852	Protein conserved in bacteria
HA514_RS19260	COG3171	Protein conserved in bacteria
HA514_RS19270	COG1194	a g-specific adenine glycosylase
HA514_RS19280	COG0741	lytic transglycosylase activity
HA514_RS19285	COG2211	Major facilitator Superfamily
HA514_RS19310	COG3052	prosthetic group binding
HA514_RS19320	COG0179	Fumarylacetoacetate (FAA) hydrolase
HA514_RS19325	COG3493	citrate carrier protein
HA514_RS19340	COG1982	Orn Lys Arg decarboxylase major
HA514_RS19345	COG1811	Na channel or pump
HA514_RS19365	COG2003	Belongs to the UPF0758 family
HA514_RS19385	COG0582	viral genome integration into host DNA
HA514_RS19470	COG3596	GTP binding
HA514_RS19480	COG2378	regulation of single-species biofilm formation
HA514_RS19490	COG2378	regulation of single-species biofilm formation
HA514_RS19510	COG2003	Belongs to the UPF0758 family
HA514_RS19550	COG0457	Tetratricopeptide repeat
HA514_RS19555	COG0726	polysaccharide deacetylase
HA514_RS19555	COG1649	PFAM Uncharacterised BCR, COG1649
HA514_RS19560	COG1215	transferase activity, transferring glycosyl groups
HA514_RS19570	COG0754	glutathionylspermidine amidase activity
HA514_RS19575	COG0625	glutathione transferase activity
HA514_RS19600	COG0667	Aldo Keto reductase
HA514_RS19605	COG2862	Uncharacterized protein family, UPF0114
HA514_RS19625	COG0848	biopolymer transport protein
HA514_RS19635	COG0626	cystathionine gamma-synthase activity
HA514_RS19640	COG0586	Pfam SNARE associated Golgi protein
HA514_RS19645	COG2207	Transcriptional regulator
HA514_RS19650	COG1979	alcohol dehydrogenase
HA514_RS19660	COG1032	radical SAM domain protein
HA514_RS19665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HA514_RS19685	COG3111	PFAM Bacterial OB fold (BOF) protein
HA514_RS19700	COG2249	NAD(P)H dehydrogenase (quinone) activity
HA514_RS19705	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HA514_RS19710	COG1652	LysM domain
HA514_RS19725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA514_RS19730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HA514_RS19735	COG1120	ATPase activity
HA514_RS19740	COG4774	siderophore transport
HA514_RS19745	COG0187	DNA topoisomerase II activity
HA514_RS19750	COG3150	esterase
HA514_RS19755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HA514_RS19760	COG3151	Protein conserved in bacteria
HA514_RS19765	COG0494	nUDIX hydrolase
HA514_RS19780	COG0754	glutathionylspermidine amidase activity
HA514_RS19785	COG3384	dioxygenase
HA514_RS19790	COG3539	Fimbrial protein
HA514_RS19795	COG3188	usher protein
HA514_RS19800	COG3121	Chaperone
HA514_RS19805	COG3539	Fimbrial protein
HA514_RS19810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HA514_RS19820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HA514_RS19820	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HA514_RS19830	COG3025	triphosphatase activity
HA514_RS19835	COG4991	sh3 domain protein
HA514_RS19840	COG0617	tRNA 3'-terminal CCA addition
HA514_RS19850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HA514_RS19860	COG0829	nickel cation binding
HA514_RS19865	COG0831	urea catabolic process
HA514_RS19870	COG0832	Belongs to the urease beta subunit family
HA514_RS19875	COG0804	urea catabolic process
HA514_RS19880	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HA514_RS19890	COG0830	nickel cation binding
HA514_RS19905	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HA514_RS19910	COG0358	DNA primase activity
HA514_RS19920	COG3663	DNA glycosylase
HA514_RS19960	COG2003	Belongs to the UPF0758 family
HA514_RS19970	COG3468	outer membrane autotransporter barrel domain protein
HA514_RS19975	COG2378	regulation of single-species biofilm formation
HA514_RS19985	COG3596	GTP binding
HA514_RS20050	COG1204	response to ionizing radiation
HA514_RS20070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HA514_RS20085	COG4735	regulation of single-species biofilm formation
HA514_RS20105	COG4983	Phage plasmid primase, P4 family domain protein
HA514_RS20180	COG2375	cellular response to nickel ion
HA514_RS20185	COG1695	Transcriptional regulator
HA514_RS20190	COG0840	transmembrane signaling receptor activity
HA514_RS20195	COG0840	transmembrane signaling receptor activity
HA514_RS20200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HA514_RS20215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HA514_RS20220	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HA514_RS20225	COG1830	Aldolase
HA514_RS20230	COG1879	ABC-type sugar transport system periplasmic component
HA514_RS20235	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA514_RS20240	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA514_RS20245	COG1129	ABC transporter
HA514_RS20250	COG2390	Transcriptional regulator
HA514_RS20255	COG1070	Carbohydrate kinase
HA514_RS20260	COG1902	pentaerythritol trinitrate reductase activity
HA514_RS20260	COG0446	pyridine nucleotide-disulphide oxidoreductase
HA514_RS20270	COG1451	nucleotide metabolic process
HA514_RS20275	COG0673	inositol 2-dehydrogenase activity
HA514_RS20280	COG0861	Integral membrane protein TerC family
HA514_RS20290	COG2721	sulfolactate sulfo-lyase activity
HA514_RS20300	COG2271	Major facilitator Superfamily
HA514_RS20305	COG2186	Transcriptional regulator
HA514_RS20310	COG0586	Pfam SNARE associated Golgi protein
HA514_RS20320	COG1422	Protein of unknown function (DUF1090)
HA514_RS20325	COG4575	ribosome binding
HA514_RS20330	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HA514_RS20340	COG2259	Doxx family
HA514_RS20345	COG0435	Glutathione S-transferase
HA514_RS20350	COG3152	Membrane
HA514_RS20355	COG0583	DNA-binding transcription factor activity
HA514_RS20360	COG1741	Belongs to the pirin family
HA514_RS20370	COG0814	amino acid
HA514_RS20395	COG1882	Formate acetyltransferase
HA514_RS20400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HA514_RS20405	COG0814	amino acid
HA514_RS20410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HA514_RS20415	COG0583	DNA-binding transcription factor activity
HA514_RS20445	COG2084	Dehydrogenase
HA514_RS20455	COG2721	sulfolactate sulfo-lyase activity
HA514_RS20470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS20475	COG3414	Phosphotransferase system galactitol-specific IIB component
HA514_RS20480	COG3775	system Galactitol-specific IIC component
HA514_RS20485	COG1063	alcohol dehydrogenase
HA514_RS20495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HA514_RS20500	COG3107	peptidoglycan biosynthetic process
HA514_RS20505	COG0792	nuclease activity
HA514_RS20510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HA514_RS20515	COG2823	Periplasmic or secreted lipoprotein
HA514_RS20520	COG0701	Predicted permease
HA514_RS20525	COG0702	epimerase
HA514_RS20530	COG0693	protein deglycase activity
HA514_RS20535	COG3787	Belongs to the UPF0306 family
HA514_RS20540	COG2827	Endonuclease containing a URI domain
HA514_RS20545	COG3153	acetyltransferase
HA514_RS20550	COG3154	lipid carrier protein
HA514_RS20555	COG0826	peptidase U32
HA514_RS20560	COG0826	peptidase U32
HA514_RS20565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HA514_RS20570	COG0814	amino acid
HA514_RS20575	COG0513	Belongs to the DEAD box helicase family
HA514_RS20595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HA514_RS20600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HA514_RS20605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HA514_RS20610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HA514_RS20630	COG0137	argininosuccinate synthase activity
HA514_RS20640	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HA514_RS20645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HA514_RS20650	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HA514_RS20655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HA514_RS20660	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HA514_RS20665	COG1534	Rna-binding protein
HA514_RS20675	COG2027	D-alanyl-D-alanine carboxypeptidase
HA514_RS20680	COG0745	RESPONSE REGULATOR receiver
HA514_RS20685	COG0642	Histidine kinase
HA514_RS20690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HA514_RS20695	COG0697	spore germination
HA514_RS20705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HA514_RS20710	COG0142	geranyltranstransferase activity
HA514_RS20715	COG3423	Transcriptional regulator
HA514_RS20720	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HA514_RS20725	COG5007	Belongs to the BolA IbaG family
HA514_RS20730	COG3113	response to antibiotic
HA514_RS20735	COG2854	intermembrane phospholipid transfer
HA514_RS20740	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HA514_RS20745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HA514_RS20750	COG1127	ABC transporter
HA514_RS20755	COG0530	calcium, potassium:sodium antiporter activity
HA514_RS20765	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HA514_RS20770	COG3117	lipopolysaccharide transmembrane transporter activity
HA514_RS20775	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HA514_RS20780	COG1137	ATPase activity
HA514_RS20785	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HA514_RS20805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HA514_RS20815	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HA514_RS20820	COG0784	Response regulator, receiver
HA514_RS20820	COG2198	Histidine kinase
HA514_RS20820	COG5002	protein histidine kinase activity
HA514_RS20825	COG0795	lipopolysaccharide-transporting ATPase activity
HA514_RS20830	COG0795	lipopolysaccharide-transporting ATPase activity
HA514_RS20835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HA514_RS20840	COG2927	DNA polymerase III (CHI subunit)
HA514_RS20855	COG1064	alcohol dehydrogenase
HA514_RS20865	COG0433	COG0433 Predicted ATPase
HA514_RS20870	COG1242	4 iron, 4 sulfur cluster binding
HA514_RS20875	COG0069	glutamate synthase activity
HA514_RS20875	COG0067	glutamate synthase
HA514_RS20875	COG0070	glutamate synthase
HA514_RS20880	COG0493	'glutamate synthase
HA514_RS20890	COG3188	usher protein
HA514_RS20895	COG3121	Chaperone
HA514_RS20900	COG3539	Fimbrial protein
HA514_RS20905	COG2969	positive regulation of protein catabolic process
HA514_RS20910	COG0625	glutathione transferase activity
HA514_RS20920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HA514_RS20930	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HA514_RS20935	COG3105	Protein conserved in bacteria
HA514_RS20940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HA514_RS20945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HA514_RS20955	COG1438	arginine binding
HA514_RS20970	COG2732	(Barnase) inhibitor
HA514_RS20975	COG1012	belongs to the aldehyde dehydrogenase family
HA514_RS20980	COG1289	transmembrane transporter activity
HA514_RS20995	COG0583	DNA-binding transcription factor activity
HA514_RS21000	COG0312	modulator of DNA gyrase
HA514_RS21005	COG3164	Protein of unknown function
HA514_RS21010	COG1530	ribonuclease E activity
HA514_RS21020	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HA514_RS21025	COG1792	Involved in formation and maintenance of cell shape
HA514_RS21030	COG1077	Cell shape determining protein MreB Mrl
HA514_RS21035	COG2200	EAL domain
HA514_RS21035	COG2199	diguanylate cyclase activity
HA514_RS21040	COG0604	alcohol dehydrogenase
HA514_RS21050	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HA514_RS21055	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HA514_RS21060	COG0511	ligase activity, forming carbon-carbon bonds
HA514_RS21065	COG0439	Biotin carboxylase
HA514_RS21080	COG3924	membrane
HA514_RS21085	COG4145	pantothenate transmembrane transporter activity
HA514_RS21090	COG2264	protein methyltransferase activity
HA514_RS21120	COG4626	Terminase
HA514_RS21120	COG1802	Transcriptional regulator
HA514_RS21200	COG3561	AntA/AntB antirepressor
HA514_RS21215	COG0582	viral genome integration into host DNA
HA514_RS21230	COG1309	transcriptional regulator
HA514_RS21235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HA514_RS21240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HA514_RS21250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HA514_RS21255	COG4597	amino acid ABC transporter
HA514_RS21260	COG0765	amino acid transport
HA514_RS21265	COG1126	abc transporter atp-binding protein
HA514_RS21300	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HA514_RS21310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HA514_RS21315	COG0009	L-threonylcarbamoyladenylate synthase
HA514_RS21320	COG0551	DNA topoisomerase type I activity
HA514_RS21325	COG2922	Belongs to the Smg family
HA514_RS21330	COG0758	DNA mediated transformation
HA514_RS21335	COG0242	peptide deformylase activity
HA514_RS21340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HA514_RS21345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HA514_RS21345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HA514_RS21360	COG3036	rescue of stalled ribosome
HA514_RS21365	COG0789	Transcriptional regulator
HA514_RS21380	COG0202	RNA polymerase activity
HA514_RS21390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HA514_RS21405	COG0201	protein transport
HA514_RS21415	COG1841	ribosomal large subunit assembly
HA514_RS21430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HA514_RS21435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HA514_RS21465	COG0255	Belongs to the universal ribosomal protein uL29 family
HA514_RS21470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HA514_RS21510	COG0051	transcription antitermination factor activity, RNA binding
HA514_RS21520	COG3267	Type II secretory pathway component ExeA
HA514_RS21520	COG3409	Peptidoglycan-binding domain 1 protein
HA514_RS21525	COG3031	protein transport across the cell outer membrane
HA514_RS21530	COG1450	Type ii and iii secretion system protein
HA514_RS21535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HA514_RS21540	COG1459	type II secretion system
HA514_RS21545	COG2165	general secretion pathway protein
HA514_RS21550	COG2165	general secretion pathway protein
HA514_RS21555	COG2165	general secretion pathway protein
HA514_RS21560	COG4795	General secretion pathway protein
HA514_RS21565	COG3156	type II secretion system protein K
HA514_RS21615	COG2168	tRNA wobble position uridine thiolation
HA514_RS21620	COG2923	Belongs to the DsrF TusC family
HA514_RS21625	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HA514_RS21630	COG2964	Protein conserved in bacteria
HA514_RS21635	COG0545	Peptidyl-prolyl cis-trans isomerase
HA514_RS21645	COG1047	Peptidyl-prolyl cis-trans
HA514_RS21650	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HA514_RS21655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HA514_RS21655	COG0475	glutathione-regulated potassium exporter activity
HA514_RS21660	COG2249	NAD(P)H dehydrogenase (quinone) activity
HA514_RS21665	COG0488	(ABC) transporter
HA514_RS21675	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HA514_RS21685	COG0679	Auxin Efflux Carrier
HA514_RS21715	COG0429	hydrolase of the alpha beta-hydrolase fold
HA514_RS21720	COG3089	Belongs to the UPF0270 family
HA514_RS21725	COG3954	Phosphoribulokinase
HA514_RS21730	COG1765	OsmC-like protein
HA514_RS21740	COG1289	transmembrane transporter activity
HA514_RS21750	COG0512	Glutamine amidotransferase of anthranilate synthase
HA514_RS21755	COG2184	nucleotidyltransferase activity
HA514_RS21765	COG0738	Major facilitator superfamily
HA514_RS21770	COG0402	S-adenosylhomocysteine deaminase activity
HA514_RS21775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HA514_RS21785	COG1648	precorrin-2 dehydrogenase activity
HA514_RS21785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HA514_RS21795	COG0180	Tryptophanyl-tRNA synthetase
HA514_RS21805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HA514_RS21810	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HA514_RS21815	COG3266	domain, Protein
HA514_RS21820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HA514_RS21825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HA514_RS21830	COG4796	Type ii and iii secretion system protein
HA514_RS21850	COG4972	Pilus assembly protein
HA514_RS21855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HA514_RS21860	COG0494	nUDIX hydrolase
HA514_RS21870	COG1011	Hydrolase
HA514_RS21875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HA514_RS21885	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HA514_RS21895	COG0745	RESPONSE REGULATOR receiver
HA514_RS21900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HA514_RS21905	COG2183	response to ionizing radiation
HA514_RS21910	COG1918	ferrous iron import across plasma membrane
HA514_RS21935	COG1040	competence protein
HA514_RS21945	COG2610	gluconate transmembrane transporter activity
HA514_RS21950	COG1640	4-alpha-glucanotransferase
HA514_RS21955	COG0058	SHG alpha-glucan phosphorylase activity
HA514_RS21960	COG2909	trisaccharide binding
HA514_RS21965	COG1349	DNA-binding transcription factor activity
HA514_RS21970	COG0705	Rhomboid family
HA514_RS21975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HA514_RS21980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HA514_RS21985	COG0058	SHG alpha-glucan phosphorylase activity
HA514_RS21990	COG0297	glycogen (starch) synthase activity
HA514_RS21995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HA514_RS22000	COG1523	belongs to the glycosyl hydrolase 13 family
HA514_RS22005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HA514_RS22010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HA514_RS22015	COG2095	MarC family integral membrane protein
HA514_RS22025	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HA514_RS22035	COG0477	Major facilitator Superfamily
HA514_RS22040	COG0628	permease
HA514_RS22045	COG2091	lysine biosynthetic process via aminoadipic acid
HA514_RS22085	COG3479	Phenolic acid decarboxylase
HA514_RS22095	COG1028	Short-chain dehydrogenase reductase Sdr
HA514_RS22100	COG0791	NLP P60 protein
HA514_RS22120	COG2132	Multicopper oxidase
HA514_RS22130	COG0739	heme binding
HA514_RS22160	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HA514_RS22225	COG2081	HI0933 family
HA514_RS22230	COG0306	phosphate transporter
HA514_RS22240	COG0589	response to stress
HA514_RS22245	COG0742	ribosomal rna small subunit methyltransferase
HA514_RS22250	COG0339	signal peptide processing
HA514_RS22255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HA514_RS22260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HA514_RS22270	COG3415	Transposase
HA514_RS22270	COG2801	Transposase and inactivated derivatives
HA514_RS22280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HA514_RS22290	COG2197	response regulator
HA514_RS22300	COG0583	DNA-binding transcription factor activity
HA514_RS22305	COG1295	ribonuclease BN
HA514_RS22310	COG0477	Major facilitator Superfamily
HA514_RS22315	COG2982	Protein involved in outer membrane biogenesis
HA514_RS22320	COG2200	EAL domain
HA514_RS22330	COG0612	Peptidase, M16
HA514_RS22335	COG1301	dicarboxylic acid transport
HA514_RS22340	COG2199	diguanylate cyclase activity
HA514_RS22340	COG2200	EAL domain
HA514_RS22345	COG3118	belongs to the thioredoxin family
HA514_RS22345	COG0457	Tetratricopeptide repeat
HA514_RS22350	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HA514_RS22355	COG1215	transferase activity, transferring glycosyl groups
HA514_RS22360	COG1215	transferase activity, transferring glycosyl groups
HA514_RS22385	COG2194	sulfuric ester hydrolase activity
HA514_RS22400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HA514_RS22430	COG4206	TonB-dependent receptor
HA514_RS22435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HA514_RS22455	COG0583	DNA-binding transcription factor activity
HA514_RS22460	COG0165	Argininosuccinate lyase
HA514_RS22470	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HA514_RS22475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HA514_RS22480	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HA514_RS22485	COG2207	Transcriptional regulator
HA514_RS22495	COG0371	Dehydrogenase
HA514_RS22500	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HA514_RS22510	COG0460	homoserine dehydrogenase
HA514_RS22510	COG0527	aspartate kinase activity
HA514_RS22515	COG0626	cystathionine gamma-synthase activity
HA514_RS22525	COG0254	rRNA binding
HA514_RS22530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HA514_RS22535	COG1609	Transcriptional regulator
HA514_RS22540	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HA514_RS22555	COG1575	Belongs to the MenA family. Type 1 subfamily
HA514_RS22565	COG3074	FtsZ-dependent cytokinesis
HA514_RS22575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HA514_RS22580	COG1494	fructose-1,6-bisphosphatase
HA514_RS22590	COG3152	Membrane
HA514_RS22600	COG0149	triose-phosphate isomerase activity
HA514_RS22610	COG2134	cdp-diacylglycerol pyrophosphatase
HA514_RS22615	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HA514_RS22620	COG0205	6-phosphofructokinase activity
HA514_RS22630	COG3678	ATP-independent chaperone mediated protein folding
HA514_RS22635	COG0745	RESPONSE REGULATOR receiver
HA514_RS22640	COG2205	protein histidine kinase activity
HA514_RS22645	COG2258	MOSC domain
HA514_RS22650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HA514_RS22660	COG1917	Cupin 2, conserved barrel domain protein
HA514_RS22660	COG4977	sequence-specific DNA binding
HA514_RS22665	COG4977	sequence-specific DNA binding
HA514_RS22670	COG1070	Carbohydrate kinase
HA514_RS22675	COG4806	L-rhamnose isomerase
HA514_RS22685	COG3254	rhamnose metabolic process
HA514_RS22690	COG2211	Major facilitator Superfamily
HA514_RS22710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HA514_RS22745	COG0437	4 iron, 4 sulfur cluster binding
HA514_RS22750	COG2864	formate dehydrogenase
HA514_RS22760	COG2831	hemolysin activation secretion protein
HA514_RS22765	COG2994	toxin metabolic process
HA514_RS22770	COG3210	domain, Protein
HA514_RS22770	COG3210	domain, Protein
HA514_RS22775	COG3210	domain, Protein
HA514_RS22810	COG0456	acetyltransferase
HA514_RS22825	COG1011	Hydrolase
HA514_RS22830	COG1349	DNA-binding transcription factor activity
HA514_RS22835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA514_RS22845	COG3684	Belongs to the aldolase LacD family
HA514_RS22855	COG1501	Belongs to the glycosyl hydrolase 31 family
HA514_RS22875	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HA514_RS22890	COG3852	Histidine kinase
HA514_RS22905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HA514_RS22910	COG3078	GTPase activator activity
HA514_RS22925	COG0204	Acyl-transferase
HA514_RS22935	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HA514_RS22940	COG3084	Protein conserved in bacteria
HA514_RS22945	COG0746	molybdenum cofactor guanylyltransferase activity
HA514_RS22950	COG1763	Mo-molybdopterin cofactor biosynthetic process
HA514_RS22980	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HA514_RS22990	COG1739	Uncharacterized protein family UPF0029
HA514_RS22995	COG0006	proline dipeptidase activity
HA514_RS23000	COG1250	3-hydroxyacyl-CoA dehydrogenase
HA514_RS23000	COG1024	Enoyl-CoA hydratase
HA514_RS23005	COG0183	Belongs to the thiolase family
HA514_RS23015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HA514_RS23025	COG0084	hydrolase, TatD family'
HA514_RS23030	COG0805	protein transport
HA514_RS23045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HA514_RS23050	COG3165	ubiquinone biosynthetic process from chorismate
HA514_RS23055	COG2226	methyltransferase
HA514_RS23060	COG1322	Protein conserved in bacteria
HA514_RS23070	COG0412	Dienelactone hydrolase
HA514_RS23080	COG0366	Alpha amylase catalytic
HA514_RS23085	COG0395	ABC-type sugar transport system, permease component
HA514_RS23090	COG1175	transmembrane transport
HA514_RS23095	COG1653	transport
HA514_RS23100	COG1609	Transcriptional regulator
HA514_RS23110	COG3842	ATPase activity
HA514_RS23115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HA514_RS23120	COG0583	DNA-binding transcription factor activity
HA514_RS23125	COG0697	spore germination
HA514_RS23130	COG0561	phosphatase activity
HA514_RS23135	COG2267	carboxylic ester hydrolase activity
HA514_RS23140	COG1280	lysine exporter protein (LysE YggA)
HA514_RS23145	COG1280	lysine exporter protein (LysE YggA)
HA514_RS23155	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HA514_RS23180	COG1011	Hydrolase
HA514_RS23215	COG0181	hydroxymethylbilane synthase activity
HA514_RS23225	COG2959	enzyme of heme biosynthesis
HA514_RS23230	COG3071	HemY protein
HA514_RS23265	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HA514_RS23280	COG2244	polysaccharide biosynthetic process
HA514_RS23285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HA514_RS23290	COG0456	acetyltransferase
HA514_RS23295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HA514_RS23300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HA514_RS23310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HA514_RS23315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HA514_RS23320	COG3118	belongs to the thioredoxin family
HA514_RS23330	COG0248	Ppx GppA phosphatase
HA514_RS23340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HA514_RS23350	COG0583	DNA-binding transcription factor activity
HA514_RS23355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HA514_RS23365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HA514_RS23370	COG3978	acetolactate synthase activity
HA514_RS23385	COG0606	chelatase, subunit chli
HA514_RS23390	COG3085	chromosome segregation
HA514_RS23435	COG2186	Transcriptional regulator
HA514_RS23440	COG0477	Major facilitator Superfamily
HA514_RS23445	COG1609	Transcriptional regulator
HA514_RS23450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HA514_RS23460	COG1172	Belongs to the binding-protein-dependent transport system permease family
HA514_RS23465	COG1129	ABC transporter
HA514_RS23470	COG1869	D-ribose catabolic process
HA514_RS23475	COG3158	transport of potassium into the cell
HA514_RS23485	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HA514_RS23490	COG2502	aspartate--ammonia ligase
HA514_RS23495	COG1522	sequence-specific DNA binding
HA514_RS23500	COG0716	FMN binding
HA514_RS23505	COG0445	tRNA wobble uridine modification
HA514_RS23510	COG0357	Ribosomal RNA small subunit methyltransferase G
HA514_RS23515	COG3312	ion transport
HA514_RS23520	COG0356	it plays a direct role in the translocation of protons across the membrane
HA514_RS23530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HA514_RS23535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HA514_RS23550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HA514_RS23555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HA514_RS23560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HA514_RS23575	COG3121	Chaperone
HA514_RS23585	COG3539	Fimbrial protein
HA514_RS23590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HA514_RS23595	COG0573	inorganic phosphate transmembrane transporter activity
HA514_RS23600	COG0581	inorganic phosphate transmembrane transporter activity
HA514_RS23605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HA514_RS23610	COG0704	Plays a role in the regulation of phosphate uptake
HA514_RS23615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HA514_RS23620	COG2252	PERMEase
HA514_RS23625	COG0431	NADPH-dependent FMN reductase
HA514_RS23630	COG2091	lysine biosynthetic process via aminoadipic acid
HA514_RS23645	COG0454	-acetyltransferase
HA514_RS23650	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HA514_RS23655	COG0706	membrane insertase activity
HA514_RS23700	COG3344	reverse transcriptase
HA514_RS23710	COG3039	Transposase
HA514_RS23800	COG1846	Transcriptional regulator
HA514_RS23820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HA514_RS23900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HA514_RS23910	COG0589	response to stress
HA514_RS23930	COG4644	lycopene metabolic process
HA514_RS23945	COG1127	ABC transporter
HA514_RS23950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HA514_RS24020	COG0058	SHG alpha-glucan phosphorylase activity
HA514_RS24025	COG0033	Phosphoglucomutase
HA514_RS24100	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HA514_RS24105	COG4804	nuclease activity
HA514_RS24115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HA514_RS24130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HA514_RS24170	COG0625	glutathione transferase activity
HA514_RS24205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HA514_RS24225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HA514_RS24275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HA514_RS24360	COG5433	transposase activity
HA514_RS24385	COG4644	lycopene metabolic process
HA514_RS24425	COG5001	Diguanylate cyclase
HA514_RS24425	COG3300	MHYT domain
HA514_RS24535	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HA514_RS24610	COG2135	peptidase activity
HA514_RS24885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HA514_RS24885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HA514_RS24965	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HA514_RS25010	COG1192	Involved in chromosome partitioning
HA514_RS25050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HA514_RS25065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HA514_RS25085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs