locus-tag	class	description
HYP11_gp039	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HYP11_gp049	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HYP11_gp079	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HYP11_gp117	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYP11_gp118	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYP11_gp119	COG1702	phosphate starvation-inducible protein PhoH
HYP11_gp142	COG0328	RNA-DNA hybrid ribonuclease activity
HYP11_gp146	COG0776	regulation of translation
HYP11_gp160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYP11_gp164	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)