locus-tag	class	description
DOU31_RS00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DOU31_RS00015	COG0594	ribonuclease P activity
DOU31_RS00020	COG0706	membrane insertase activity
DOU31_RS00030	COG0745	RESPONSE REGULATOR receiver
DOU31_RS00040	COG2851	Citrate transporter
DOU31_RS00050	COG0511	ligase activity, forming carbon-carbon bonds
DOU31_RS00055	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DOU31_RS00065	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
DOU31_RS00070	COG3052	prosthetic group binding
DOU31_RS00100	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DOU31_RS00115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DOU31_RS00120	COG0445	tRNA wobble uridine modification
DOU31_RS00125	COG0582	viral genome integration into host DNA
DOU31_RS00210	COG3730	PTS system glucitol sorbitol-specific
DOU31_RS00215	COG3732	PTS system glucitol sorbitol-specific
DOU31_RS00255	COG0357	Ribosomal RNA small subunit methyltransferase G
DOU31_RS00260	COG1192	Involved in chromosome partitioning
DOU31_RS00265	COG1475	DNA binding
DOU31_RS00270	COG4481	Protein conserved in bacteria
DOU31_RS00275	COG0012	GTP binding
DOU31_RS00290	COG0517	IMP dehydrogenase activity
DOU31_RS00290	COG0516	GMP reductase activity
DOU31_RS00295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DOU31_RS00370	COG1737	Transcriptional regulator
DOU31_RS00375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS00380	COG0626	cystathionine gamma-synthase activity
DOU31_RS00385	COG4463	regulation of RNA biosynthetic process
DOU31_RS00390	COG0542	response to heat
DOU31_RS00400	COG0826	peptidase U32
DOU31_RS00405	COG0826	peptidase U32
DOU31_RS00445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DOU31_RS00450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DOU31_RS00460	COG0302	gtp cyclohydrolase
DOU31_RS00465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DOU31_RS00470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DOU31_RS00485	COG0142	geranyltranstransferase activity
DOU31_RS00505	COG4939	FMN-binding domain protein
DOU31_RS00515	COG1575	Belongs to the MenA family. Type 1 subfamily
DOU31_RS00555	COG1316	TRANSCRIPTIONal
DOU31_RS00565	COG3397	chitin binding
DOU31_RS00595	COG0085	RNA polymerase activity
DOU31_RS00600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DOU31_RS00605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DOU31_RS00610	COG1070	Carbohydrate kinase
DOU31_RS00620	COG0783	Belongs to the Dps family
DOU31_RS00630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DOU31_RS00635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DOU31_RS00640	COG1368	sulfuric ester hydrolase activity
DOU31_RS00665	COG3716	PTS system mannose fructose sorbose family IID component
DOU31_RS00670	COG3715	PTS system
DOU31_RS00685	COG1131	(ABC) transporter
DOU31_RS00690	COG0842	Transport permease protein
DOU31_RS00695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOU31_RS00705	COG0803	Belongs to the bacterial solute-binding protein 9 family
DOU31_RS00705	COG3443	Belongs to the bacterial solute-binding protein 9 family
DOU31_RS00720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DOU31_RS00725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DOU31_RS00740	COG2011	ABC-type metal ion transport system permease component
DOU31_RS00750	COG3275	phosphorelay sensor kinase activity
DOU31_RS00755	COG3279	Response regulator of the LytR AlgR family
DOU31_RS00765	COG1346	cytolysis
DOU31_RS00770	COG1335	isochorismatase
DOU31_RS00840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOU31_RS00855	COG1959	2 iron, 2 sulfur cluster binding
DOU31_RS00860	COG2910	NAD(P)H-binding
DOU31_RS00870	COG1058	Belongs to the CinA family
DOU31_RS00870	COG1546	Belongs to the CinA family
DOU31_RS00875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DOU31_RS00885	COG1418	mRNA catabolic process
DOU31_RS00890	COG1692	metallophosphoesterase
DOU31_RS00895	COG4550	Control of competence regulator ComK, YlbF/YmcA
DOU31_RS00900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DOU31_RS00905	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DOU31_RS00910	COG0424	maF-like protein
DOU31_RS00920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DOU31_RS00940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOU31_RS00945	COG1554	hydrolase, family 65, central catalytic
DOU31_RS00950	COG2188	Transcriptional regulator
DOU31_RS00965	COG1970	mechanosensitive ion channel activity
DOU31_RS00970	COG0612	Peptidase, M16
DOU31_RS00975	COG0612	Peptidase, M16
DOU31_RS00980	COG1426	Protein conserved in bacteria
DOU31_RS01020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DOU31_RS01035	COG1737	Transcriptional regulator
DOU31_RS01045	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DOU31_RS01055	COG0371	Dehydrogenase
DOU31_RS01065	COG3716	PTS system mannose fructose sorbose family IID component
DOU31_RS01070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS01080	COG1312	Catalyzes the dehydration of D-mannonate
DOU31_RS01085	COG0800	Aldolase
DOU31_RS01115	COG0194	GDP metabolic process
DOU31_RS01120	COG1758	RNA polymerase activity
DOU31_RS01130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DOU31_RS01140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DOU31_RS01145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DOU31_RS01145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DOU31_RS01155	COG0515	serine threonine protein kinase
DOU31_RS01155	COG2815	serine threonine protein kinase
DOU31_RS01160	COG1162	GTPase activity
DOU31_RS01165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DOU31_RS01175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DOU31_RS01185	COG1461	Dihydroxyacetone kinase
DOU31_RS01190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DOU31_RS01195	COG0416	fatty acid biosynthetic process
DOU31_RS01200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DOU31_RS01210	COG4608	Belongs to the ABC transporter superfamily
DOU31_RS01215	COG0601	transmembrane transport
DOU31_RS01230	COG0571	ribonuclease III activity
DOU31_RS01235	COG1196	nuclear chromosome segregation
DOU31_RS01240	COG0561	phosphatase activity
DOU31_RS01245	COG0552	protein localization to endoplasmic reticulum
DOU31_RS01260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOU31_RS01270	COG2918	glutathione biosynthetic process
DOU31_RS01270	COG1181	Belongs to the D-alanine--D-alanine ligase family
DOU31_RS01290	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOU31_RS01295	COG4605	iron ion homeostasis
DOU31_RS01300	COG4604	ABC transporter, ATP-binding protein
DOU31_RS01305	COG4607	ABC-type enterochelin transport system periplasmic component
DOU31_RS01310	COG4166	transmembrane transport
DOU31_RS01315	COG2195	Cleaves the N-terminal amino acid of tripeptides
DOU31_RS01320	COG0519	Catalyzes the synthesis of GMP from XMP
DOU31_RS01325	COG4493	Belongs to the UPF0637 family
DOU31_RS01350	COG1268	BioY protein
DOU31_RS01360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DOU31_RS01380	COG0242	peptide deformylase activity
DOU31_RS01385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DOU31_RS01390	COG1185	polyribonucleotide nucleotidyltransferase activity
DOU31_RS01420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DOU31_RS01430	COG3764	Sortase (surface protein transpeptidase)
DOU31_RS01460	COG0519	Catalyzes the synthesis of GMP from XMP
DOU31_RS01465	COG4166	transmembrane transport
DOU31_RS01480	COG1363	Peptidase, m42
DOU31_RS01485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DOU31_RS01495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOU31_RS01500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DOU31_RS01505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DOU31_RS01515	COG5492	domain, Protein
DOU31_RS01520	COG1823	symporter activity
DOU31_RS01560	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DOU31_RS01565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DOU31_RS01610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS01615	COG2723	6-phospho-beta-galactosidase activity
DOU31_RS01620	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DOU31_RS01625	COG0659	secondary active sulfate transmembrane transporter activity
DOU31_RS01635	COG1846	Transcriptional regulator
DOU31_RS01645	COG1953	Uracil, thiamine, allantoin
DOU31_RS01650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DOU31_RS01655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOU31_RS01660	COG3257	ureidoglycine aminohydrolase activity
DOU31_RS01665	COG2508	Transcriptional regulator
DOU31_RS01670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DOU31_RS01680	COG1937	Protein conserved in bacteria
DOU31_RS01690	COG0446	pyridine nucleotide-disulphide oxidoreductase
DOU31_RS01700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DOU31_RS01705	COG1136	(ABC) transporter
DOU31_RS01710	COG0577	efflux transmembrane transporter activity
DOU31_RS01740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS01745	COG3715	PTS system
DOU31_RS01750	COG3716	PTS system mannose fructose sorbose family IID component
DOU31_RS01765	COG1193	negative regulation of DNA recombination
DOU31_RS01770	COG1785	Belongs to the alkaline phosphatase family
DOU31_RS01775	COG1834	amidinotransferase
DOU31_RS01805	COG3711	transcriptional antiterminator
DOU31_RS01820	COG0657	acetylesterase activity
DOU31_RS01825	COG1609	Transcriptional regulator
DOU31_RS01835	COG1869	D-ribose catabolic process
DOU31_RS01840	COG4975	Glucose uptake
DOU31_RS01845	COG0583	DNA-binding transcription factor activity
DOU31_RS01850	COG0110	maltose O-acetyltransferase activity
DOU31_RS01855	COG4221	oxidoreductase activity
DOU31_RS01860	COG2252	PERMEase
DOU31_RS01865	COG0301	tRNA thio-modification
DOU31_RS01870	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DOU31_RS01875	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DOU31_RS01880	COG0525	valine-tRNA ligase activity
DOU31_RS01900	COG0285	dihydrofolate synthase activity
DOU31_RS01905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOU31_RS01910	COG2003	Belongs to the UPF0758 family
DOU31_RS01945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DOU31_RS01950	COG2003	Belongs to the UPF0758 family
DOU31_RS01960	COG2003	Belongs to the UPF0758 family
DOU31_RS01965	COG0477	Major facilitator Superfamily
DOU31_RS01980	COG0488	(ABC) transporter
DOU31_RS01990	COG1278	Cold shock
DOU31_RS02000	COG5503	Protein of unknown function (DUF1447)
DOU31_RS02005	COG2832	Protein of unknown function (DUF454)
DOU31_RS02015	COG1132	(ABC) transporter
DOU31_RS02025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DOU31_RS02030	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DOU31_RS02040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DOU31_RS02045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DOU31_RS02055	COG4585	Histidine kinase
DOU31_RS02060	COG2197	response regulator
DOU31_RS02065	COG0569	domain protein
DOU31_RS02070	COG4841	protein insertion into membrane
DOU31_RS02075	COG0463	Glycosyl transferase, family 2
DOU31_RS02080	COG3842	ATPase activity
DOU31_RS02085	COG1175	transmembrane transport
DOU31_RS02105	COG0737	Belongs to the 5'-nucleotidase family
DOU31_RS02120	COG0492	ferredoxin-NADP+ reductase activity
DOU31_RS02135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DOU31_RS02140	COG1098	S1 RNA binding domain
DOU31_RS02195	COG0438	transferase activity, transferring glycosyl groups
DOU31_RS02200	COG2084	Dehydrogenase
DOU31_RS02205	COG4703	Protein of unknown function (DUF1797)
DOU31_RS02210	COG1846	Transcriptional regulator
DOU31_RS02215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DOU31_RS02230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DOU31_RS02240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DOU31_RS02250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DOU31_RS02255	COG0439	Biotin carboxylase
DOU31_RS02260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DOU31_RS02265	COG0825	malonyl-CoA metabolic process
DOU31_RS02275	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DOU31_RS02280	COG1534	Rna-binding protein
DOU31_RS02285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DOU31_RS02290	COG1713	HD superfamily hydrolase involved in NAD metabolism
DOU31_RS02295	COG0799	negative regulation of ribosome biogenesis
DOU31_RS02300	COG2226	methyltransferase
DOU31_RS02305	COG1323	Belongs to the UPF0348 family
DOU31_RS02310	COG0217	transcriptional regulatory protein
DOU31_RS02355	COG1876	peptidase activity
DOU31_RS02360	COG1942	4-Oxalocrotonate Tautomerase
DOU31_RS02365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DOU31_RS02370	COG0768	penicillin binding
DOU31_RS02375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DOU31_RS02420	COG1073	alpha beta
DOU31_RS02425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DOU31_RS02440	COG1940	carbohydrate kinase activity
DOU31_RS02445	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DOU31_RS02455	COG3189	MarR family transcriptional regulator
DOU31_RS02470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DOU31_RS02475	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DOU31_RS02480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DOU31_RS02485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DOU31_RS02495	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DOU31_RS02500	COG0352	thiamine-phosphate diphosphorylase activity
DOU31_RS02505	COG0351	phosphomethylpyrimidine kinase
DOU31_RS02510	COG1733	regulation of RNA biosynthetic process
DOU31_RS02515	COG2814	Major facilitator Superfamily
DOU31_RS02520	COG0477	Major facilitator Superfamily
DOU31_RS02540	COG1122	ATPase activity
DOU31_RS02550	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DOU31_RS02555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DOU31_RS02565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DOU31_RS02570	COG3870	Protein conserved in bacteria
DOU31_RS02575	COG0470	DNA polymerase III
DOU31_RS02580	COG1774	PSP1 C-terminal conserved region
DOU31_RS02585	COG4467	Involved in initiation control of chromosome replication
DOU31_RS02595	COG4619	ABC transporter
DOU31_RS02600	COG0390	transport system, permease component
DOU31_RS02610	COG0602	queuosine metabolic process
DOU31_RS02615	COG1328	CTP reductase activity
DOU31_RS02620	COG1136	(ABC) transporter
DOU31_RS02625	COG0577	efflux transmembrane transporter activity
DOU31_RS02635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DOU31_RS02640	COG1696	Membrane protein involved in D-alanine export
DOU31_RS02645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DOU31_RS02650	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DOU31_RS02655	COG1363	Peptidase, m42
DOU31_RS02665	COG1234	tRNA 3'-trailer cleavage
DOU31_RS02670	COG0095	Lipoate-protein ligase
DOU31_RS02700	COG0708	Exodeoxyribonuclease III
DOU31_RS02710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DOU31_RS02725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DOU31_RS02730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DOU31_RS02735	COG0250	Participates in transcription elongation, termination and antitermination
DOU31_RS02750	COG4166	transmembrane transport
DOU31_RS02755	COG1363	Peptidase, m42
DOU31_RS02765	COG1760	l-serine dehydratase
DOU31_RS02770	COG1760	l-serine dehydratase
DOU31_RS02775	COG0488	(ABC) transporter
DOU31_RS02780	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DOU31_RS02785	COG0081	regulation of translation
DOU31_RS02795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DOU31_RS02800	COG0222	ribosome binding
DOU31_RS02810	COG1917	Cupin 2, conserved barrel domain protein
DOU31_RS02810	COG2207	Transcriptional regulator
DOU31_RS02815	COG0531	amino acid
DOU31_RS02820	COG3250	beta-galactosidase activity
DOU31_RS02825	COG2261	transglycosylase associated protein
DOU31_RS02835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DOU31_RS02840	COG2137	regulation of response to DNA damage stimulus
DOU31_RS02845	COG1194	a g-specific adenine glycosylase
DOU31_RS02875	COG3853	Toxic anion resistance protein (TelA)
DOU31_RS02885	COG0494	nUDIX hydrolase
DOU31_RS02895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DOU31_RS02900	COG2827	Endonuclease containing a URI domain
DOU31_RS02905	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DOU31_RS02910	COG0204	Acyl-transferase
DOU31_RS02915	COG0420	3'-5' exonuclease activity
DOU31_RS02920	COG0419	ATPase involved in DNA repair
DOU31_RS02970	COG1132	(ABC) transporter
DOU31_RS02975	COG0180	Tryptophanyl-tRNA synthetase
DOU31_RS02980	COG1393	Belongs to the ArsC family
DOU31_RS02985	COG4862	establishment of competence for transformation
DOU31_RS02995	COG1164	Oligoendopeptidase f
DOU31_RS03010	COG4116	CYTH
DOU31_RS03015	COG2357	RelA SpoT domain protein
DOU31_RS03020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DOU31_RS03025	COG0564	pseudouridine synthase activity
DOU31_RS03030	COG2239	Acts as a magnesium transporter
DOU31_RS03035	COG3142	Participates in the control of copper homeostasis
DOU31_RS03050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DOU31_RS03060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DOU31_RS03075	COG2348	transferase activity, transferring amino-acyl groups
DOU31_RS03080	COG4684	Psort location CytoplasmicMembrane, score
DOU31_RS03085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DOU31_RS03095	COG0604	alcohol dehydrogenase
DOU31_RS03105	COG3842	ATPase activity
DOU31_RS03110	COG1176	ABC-type spermidine putrescine transport system, permease component I
DOU31_RS03115	COG1177	transmembrane transport
DOU31_RS03120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DOU31_RS03130	COG2610	gluconate transmembrane transporter activity
DOU31_RS03135	COG1929	Belongs to the glycerate kinase type-1 family
DOU31_RS03140	COG3835	regulator
DOU31_RS03145	COG1597	lipid kinase activity
DOU31_RS03160	COG3448	diguanylate cyclase activity
DOU31_RS03160	COG4175	Glycine betaine
DOU31_RS03170	COG0488	(ABC) transporter
DOU31_RS03175	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DOU31_RS03190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DOU31_RS03195	COG0459	protein refolding
DOU31_RS03210	COG3942	CHAP domain
DOU31_RS03210	COG1705	Flagellar rod assembly protein muramidase FlgJ
DOU31_RS03215	COG2246	polysaccharide biosynthetic process
DOU31_RS03220	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DOU31_RS03225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DOU31_RS03240	COG3592	Divergent 4Fe-4S mono-cluster
DOU31_RS03245	COG2388	GCN5-related N-acetyl-transferase
DOU31_RS03250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DOU31_RS03265	COG0557	exoribonuclease II activity
DOU31_RS03270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DOU31_RS03280	COG0356	it plays a direct role in the translocation of protons across the membrane
DOU31_RS03285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DOU31_RS03290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DOU31_RS03295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DOU31_RS03300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DOU31_RS03305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DOU31_RS03310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DOU31_RS03315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DOU31_RS03320	COG4836	Membrane
DOU31_RS03325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DOU31_RS03340	COG0628	permease
DOU31_RS03345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DOU31_RS03355	COG3711	transcriptional antiterminator
DOU31_RS03360	COG2190	(PTS) system
DOU31_RS03360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS03360	COG1263	PTS System
DOU31_RS03365	COG2723	6-phospho-beta-galactosidase activity
DOU31_RS03370	COG0194	GDP metabolic process
DOU31_RS03385	COG1132	(ABC) transporter
DOU31_RS03400	COG1482	cell wall glycoprotein biosynthetic process
DOU31_RS03410	COG1957	nucleoside hydrolase
DOU31_RS03415	COG3442	glutamine amidotransferase
DOU31_RS03420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DOU31_RS03430	COG0402	S-adenosylhomocysteine deaminase activity
DOU31_RS03435	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DOU31_RS03435	COG0493	'glutamate synthase
DOU31_RS03450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DOU31_RS03455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DOU31_RS03465	COG0549	Belongs to the carbamate kinase family
DOU31_RS03470	COG0251	oxidation-reduction process
DOU31_RS03485	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DOU31_RS03485	COG3608	succinylglutamate desuccinylase aspartoacylase
DOU31_RS03495	COG0746	molybdenum cofactor guanylyltransferase activity
DOU31_RS03500	COG1104	cysteine desulfurase activity
DOU31_RS03520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DOU31_RS03525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DOU31_RS03525	COG3608	succinylglutamate desuccinylase aspartoacylase
DOU31_RS03530	COG0716	FMN binding
DOU31_RS03535	COG0543	2 iron, 2 sulfur cluster binding
DOU31_RS03540	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
DOU31_RS03540	COG0493	'glutamate synthase
DOU31_RS03550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DOU31_RS03555	COG1053	succinate dehydrogenase
DOU31_RS03560	COG1435	thymidine kinase activity
DOU31_RS03565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DOU31_RS03570	COG2890	protein-(glutamine-N5) methyltransferase activity
DOU31_RS03575	COG0009	L-threonylcarbamoyladenylate synthase
DOU31_RS03580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DOU31_RS03585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DOU31_RS03620	COG1396	sequence-specific DNA binding
DOU31_RS03645	COG0772	Belongs to the SEDS family
DOU31_RS03650	COG1393	Belongs to the ArsC family
DOU31_RS03655	COG0509	glycine decarboxylation via glycine cleavage system
DOU31_RS03670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DOU31_RS03675	COG2011	ABC-type metal ion transport system permease component
DOU31_RS03680	COG1464	Belongs to the NlpA lipoprotein family
DOU31_RS03685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DOU31_RS03690	COG4589	Belongs to the CDS family
DOU31_RS03705	COG0546	phosphoglycolate phosphatase activity
DOU31_RS03735	COG1214	PFAM Peptidase M22, glycoprotease
DOU31_RS03745	COG0456	acetyltransferase
DOU31_RS03750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DOU31_RS03755	COG0018	arginyl-trna synthetase
DOU31_RS03775	COG0038	chloride channel
DOU31_RS03780	COG4476	Belongs to the UPF0223 family
DOU31_RS03785	COG0483	inositol monophosphate 1-phosphatase activity
DOU31_RS03790	COG1217	gtp-binding protein TYPA
DOU31_RS03795	COG0514	ATP-dependent DNA helicase (RecQ)
DOU31_RS03800	COG4838	Belongs to the UPF0358 family
DOU31_RS03805	COG0772	Belongs to the SEDS family
DOU31_RS03810	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DOU31_RS03825	COG4471	UPF0298 protein
DOU31_RS03830	COG0742	ribosomal rna small subunit methyltransferase
DOU31_RS03835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DOU31_RS03840	COG3480	Lon protease (S16) C-terminal proteolytic domain
DOU31_RS03845	COG1555	photosystem II stabilization
DOU31_RS03850	COG2131	deaminase
DOU31_RS03855	COG0658	competence protein
DOU31_RS03855	COG2333	competence protein COMEC
DOU31_RS03860	COG1466	dna polymerase III delta subunit
DOU31_RS03865	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DOU31_RS03870	COG1607	acyl-coa hydrolase
DOU31_RS03875	COG0268	Binds directly to 16S ribosomal RNA
DOU31_RS03885	COG0306	phosphate transporter
DOU31_RS03895	COG3394	polysaccharide catabolic process
DOU31_RS03900	COG1968	undecaprenyl-diphosphatase activity
DOU31_RS03905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS03905	COG1263	PTS System
DOU31_RS03905	COG2190	(PTS) system
DOU31_RS03915	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DOU31_RS03920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS03920	COG1263	PTS System
DOU31_RS03925	COG1737	Transcriptional regulator
DOU31_RS03940	COG0402	S-adenosylhomocysteine deaminase activity
DOU31_RS03950	COG0516	GMP reductase activity
DOU31_RS03965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DOU31_RS03970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DOU31_RS03975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DOU31_RS03980	COG0640	Transcriptional regulator
DOU31_RS03985	COG0460	homoserine dehydrogenase
DOU31_RS03995	COG0083	homoserine kinase activity
DOU31_RS04000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DOU31_RS04005	COG0735	belongs to the Fur family
DOU31_RS04010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DOU31_RS04015	COG1610	YqeY-like protein
DOU31_RS04020	COG1702	phosphate starvation-inducible protein PhoH
DOU31_RS04030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DOU31_RS04035	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DOU31_RS04040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DOU31_RS04045	COG1381	Involved in DNA repair and RecF pathway recombination
DOU31_RS04055	COG0752	glycyl-tRNA synthetase alpha subunit
DOU31_RS04060	COG0751	glycine-tRNA ligase activity
DOU31_RS04070	COG0706	membrane insertase activity
DOU31_RS04080	COG1254	Belongs to the acylphosphatase family
DOU31_RS04085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOU31_RS04095	COG0052	Belongs to the universal ribosomal protein uS2 family
DOU31_RS04100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DOU31_RS04105	COG0528	UMP kinase activity
DOU31_RS04110	COG0233	cytoplasmic translational termination
DOU31_RS04120	COG0719	Fe-S assembly protein
DOU31_RS04125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DOU31_RS04135	COG0719	Fe-S assembly protein
DOU31_RS04145	COG1028	Short-chain dehydrogenase reductase Sdr
DOU31_RS04150	COG0750	zinc metalloprotease
DOU31_RS04155	COG0442	prolyl-tRNA aminoacylation
DOU31_RS04165	COG0531	amino acid
DOU31_RS04175	COG1199	ATP-dependent helicase activity
DOU31_RS04175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DOU31_RS04185	COG0436	Aminotransferase
DOU31_RS04190	COG0017	Asparaginyl-tRNA synthetase
DOU31_RS04210	COG1705	Flagellar rod assembly protein muramidase FlgJ
DOU31_RS04220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DOU31_RS04235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DOU31_RS04240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DOU31_RS04250	COG0542	response to heat
DOU31_RS04265	COG0481	GTPase activity
DOU31_RS04270	COG1609	Transcriptional regulator
DOU31_RS04275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DOU31_RS04280	COG3962	Belongs to the TPP enzyme family
DOU31_RS04285	COG3718	enzyme involved in inositol metabolism
DOU31_RS04290	COG1012	belongs to the aldehyde dehydrogenase family
DOU31_RS04300	COG0673	inositol 2-dehydrogenase activity
DOU31_RS04305	COG1082	Xylose isomerase domain protein TIM barrel
DOU31_RS04310	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DOU31_RS04325	COG1609	Transcriptional regulator
DOU31_RS04340	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DOU31_RS04350	COG1175	transmembrane transport
DOU31_RS04355	COG0395	ABC-type sugar transport system, permease component
DOU31_RS04380	COG1132	(ABC) transporter
DOU31_RS04405	COG1175	transmembrane transport
DOU31_RS04410	COG0395	ABC-type sugar transport system, permease component
DOU31_RS04415	COG1653	transport
DOU31_RS04425	COG2972	Histidine kinase
DOU31_RS04430	COG4753	response regulator
DOU31_RS04430	COG2207	Transcriptional regulator
DOU31_RS04450	COG0346	lactoylglutathione lyase activity
DOU31_RS04455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS04455	COG1263	PTS System
DOU31_RS04470	COG2738	Putative neutral zinc metallopeptidase
DOU31_RS04480	COG0384	phenazine biosynthesis protein PhzF
DOU31_RS04490	COG0590	tRNA wobble adenosine to inosine editing
DOU31_RS04500	COG0582	viral genome integration into host DNA
DOU31_RS04535	COG3561	AntA/AntB antirepressor
DOU31_RS04585	COG0629	single-stranded DNA binding
DOU31_RS04680	COG1783	phage Terminase large subunit
DOU31_RS04770	COG0584	glycerophosphoryl diester phosphodiesterase
DOU31_RS04825	COG2309	aminopeptidase activity
DOU31_RS04830	COG1309	transcriptional regulator
DOU31_RS04835	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DOU31_RS04840	COG0716	FMN binding
DOU31_RS04845	COG0024	Methionine aminopeptidase
DOU31_RS04850	COG1295	ribonuclease BN
DOU31_RS04855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DOU31_RS04875	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DOU31_RS04885	COG1088	dTDP-glucose 4,6-dehydratase activity
DOU31_RS04890	COG1091	dTDP-4-dehydrorhamnose reductase activity
DOU31_RS04895	COG1215	transferase activity, transferring glycosyl groups
DOU31_RS04910	COG1682	transport, permease protein
DOU31_RS04915	COG1134	teichoic acid transport
DOU31_RS04920	COG0438	transferase activity, transferring glycosyl groups
DOU31_RS04920	COG1216	Glycosyl transferase, family 2
DOU31_RS04925	COG0438	transferase activity, transferring glycosyl groups
DOU31_RS04925	COG1216	Glycosyl transferase, family 2
DOU31_RS04940	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DOU31_RS04950	COG3475	LICD family
DOU31_RS04965	COG1216	Glycosyl transferase, family 2
DOU31_RS04970	COG1216	Glycosyl transferase, family 2
DOU31_RS04970	COG1442	glycosyl transferase family 8
DOU31_RS04975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DOU31_RS04975	COG0463	Glycosyl transferase, family 2
DOU31_RS04980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DOU31_RS04985	COG0463	Glycosyl transferase, family 2
DOU31_RS04985	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DOU31_RS05005	COG0463	Glycosyl transferase, family 2
DOU31_RS05010	COG0584	glycerophosphoryl diester phosphodiesterase
DOU31_RS05015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DOU31_RS05020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DOU31_RS05025	COG0789	Transcriptional regulator
DOU31_RS05045	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DOU31_RS05055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DOU31_RS05060	COG4720	Psort location CytoplasmicMembrane, score
DOU31_RS05065	COG1122	ATPase activity
DOU31_RS05075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DOU31_RS05120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DOU31_RS05125	COG2011	ABC-type metal ion transport system permease component
DOU31_RS05135	COG1473	amidohydrolase
DOU31_RS05145	COG0488	(ABC) transporter
DOU31_RS05155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DOU31_RS05160	COG1121	(ABC) transporter
DOU31_RS05165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DOU31_RS05170	COG1104	cysteine desulfurase activity
DOU31_RS05180	COG0482	sulfurtransferase activity
DOU31_RS05190	COG2814	Major facilitator Superfamily
DOU31_RS05195	COG1881	PFAM PEBP family protein
DOU31_RS05215	COG3708	Transcriptional regulator
DOU31_RS05215	COG2207	Transcriptional regulator
DOU31_RS05230	COG1271	oxidase subunit
DOU31_RS05235	COG1294	oxidase, subunit
DOU31_RS05240	COG4988	ABC transporter
DOU31_RS05245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DOU31_RS05260	COG1252	NADH dehydrogenase
DOU31_RS05270	COG1674	ftsk spoiiie
DOU31_RS05280	COG1136	(ABC) transporter
DOU31_RS05285	COG0577	efflux transmembrane transporter activity
DOU31_RS05290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DOU31_RS05300	COG0531	amino acid
DOU31_RS05305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DOU31_RS05315	COG4537	Required for transformation and DNA binding
DOU31_RS05325	COG0582	viral genome integration into host DNA
DOU31_RS05330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DOU31_RS05340	COG1396	sequence-specific DNA binding
DOU31_RS05570	COG0827	DNA restriction-modification system
DOU31_RS05575	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DOU31_RS05580	COG0589	response to stress
DOU31_RS05600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DOU31_RS05605	COG2094	Belongs to the DNA glycosylase MPG family
DOU31_RS05615	COG2264	protein methyltransferase activity
DOU31_RS05620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DOU31_RS05625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DOU31_RS05630	COG1490	D-aminoacyl-tRNA deacylase activity
DOU31_RS05640	COG0124	histidyl-tRNA synthetase
DOU31_RS05645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DOU31_RS05650	COG0351	phosphomethylpyrimidine kinase
DOU31_RS05655	COG4720	Psort location CytoplasmicMembrane, score
DOU31_RS05660	COG4475	Protein of unknown function (DUF436)
DOU31_RS05665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOU31_RS05670	COG2390	Transcriptional regulator
DOU31_RS05680	COG0126	phosphoglycerate kinase activity
DOU31_RS05685	COG0149	triose-phosphate isomerase activity
DOU31_RS05705	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DOU31_RS05715	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DOU31_RS05715	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DOU31_RS05730	COG3715	PTS system
DOU31_RS05735	COG3716	PTS system mannose fructose sorbose family IID component
DOU31_RS05740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DOU31_RS05780	COG1368	sulfuric ester hydrolase activity
DOU31_RS05785	COG2814	Major facilitator Superfamily
DOU31_RS05795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOU31_RS05800	COG2364	Membrane
DOU31_RS05845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DOU31_RS05855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DOU31_RS05885	COG3069	C4-dicarboxylate transmembrane transporter activity
DOU31_RS05895	COG2706	6-phosphogluconolactonase activity
DOU31_RS05900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DOU31_RS05905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DOU31_RS05920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DOU31_RS05925	COG1940	carbohydrate kinase activity
DOU31_RS05935	COG4129	membrane
DOU31_RS05945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DOU31_RS05965	COG0584	glycerophosphoryl diester phosphodiesterase
DOU31_RS05970	COG0398	Pfam SNARE associated Golgi protein
DOU31_RS05980	COG1914	H( )-stimulated, divalent metal cation uptake system
DOU31_RS05985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DOU31_RS05990	COG0336	Belongs to the RNA methyltransferase TrmD family
DOU31_RS05995	COG0335	large ribosomal subunit rRNA binding
DOU31_RS06070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DOU31_RS06085	COG0726	polysaccharide deacetylase
DOU31_RS06100	COG1349	DNA-binding transcription factor activity
DOU31_RS06105	COG3775	system Galactitol-specific IIC component
DOU31_RS06120	COG0698	ribose 5-phosphate isomerase
DOU31_RS06125	COG0698	ribose 5-phosphate isomerase
DOU31_RS06135	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS06140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS06140	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS06150	COG3716	PTS system mannose fructose sorbose family IID component
DOU31_RS06155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DOU31_RS06160	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DOU31_RS06165	COG1691	(AIR) carboxylase
DOU31_RS06170	COG3875	lactate racemase activity
DOU31_RS06175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOU31_RS06180	COG0310	cobalt ion transport
DOU31_RS06195	COG1606	tRNA processing
DOU31_RS06230	COG1064	alcohol dehydrogenase
DOU31_RS06245	COG1705	Flagellar rod assembly protein muramidase FlgJ
DOU31_RS06245	COG3942	CHAP domain
DOU31_RS06265	COG3227	Zinc metalloprotease (Elastase)
DOU31_RS06280	COG0583	DNA-binding transcription factor activity
DOU31_RS06290	COG1368	sulfuric ester hydrolase activity
DOU31_RS06300	COG1442	glycosyl transferase family 8
DOU31_RS06305	COG1442	glycosyl transferase family 8
DOU31_RS06310	COG2188	Transcriptional regulator
DOU31_RS06315	COG2222	sugar isomerase
DOU31_RS06320	COG3684	Belongs to the aldolase LacD family
DOU31_RS06325	COG1105	Belongs to the carbohydrate kinase PfkB family
DOU31_RS06335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS06335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS06340	COG3715	PTS system
DOU31_RS06345	COG3716	PTS system mannose fructose sorbose family IID component
DOU31_RS06355	COG1470	cell adhesion involved in biofilm formation
DOU31_RS06355	COG0366	Alpha amylase catalytic
DOU31_RS06360	COG0628	permease
DOU31_RS06375	COG4876	unkown
DOU31_RS06380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DOU31_RS06390	COG4166	transmembrane transport
DOU31_RS06395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DOU31_RS06405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DOU31_RS06410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DOU31_RS06415	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DOU31_RS06420	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DOU31_RS06425	COG0047	phosphoribosylformylglycinamidine synthase activity
DOU31_RS06430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DOU31_RS06435	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DOU31_RS06440	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DOU31_RS06445	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DOU31_RS06450	COG0138	bifunctional purine biosynthesis protein purh
DOU31_RS06455	COG0151	Belongs to the GarS family
DOU31_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
DOU31_RS06485	COG1739	Uncharacterized protein family UPF0029
DOU31_RS06495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS06505	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DOU31_RS06525	COG0653	protein targeting
DOU31_RS06535	COG2884	Cell division ATP-binding protein ftsE
DOU31_RS06540	COG2177	Part of the ABC transporter FtsEX involved in
DOU31_RS06550	COG0573	inorganic phosphate transmembrane transporter activity
DOU31_RS06555	COG0581	inorganic phosphate transmembrane transporter activity
DOU31_RS06560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DOU31_RS06565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DOU31_RS06570	COG0704	Plays a role in the regulation of phosphate uptake
DOU31_RS06575	COG3595	metallopeptidase activity
DOU31_RS06585	COG1950	PFAM Membrane protein of
DOU31_RS06590	COG0322	excinuclease ABC activity
DOU31_RS06595	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DOU31_RS06600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DOU31_RS06605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DOU31_RS06610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DOU31_RS06620	COG4980	gas vesicle protein
DOU31_RS06625	COG0006	proline dipeptidase activity
DOU31_RS06630	COG1609	Transcriptional regulator
DOU31_RS06645	COG1131	(ABC) transporter
DOU31_RS06660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DOU31_RS06680	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DOU31_RS06690	COG3763	UPF0154 protein
DOU31_RS06695	COG1132	(ABC) transporter
DOU31_RS06700	COG1132	(ABC) transporter
DOU31_RS06705	COG0710	3-dehydroquinate dehydratase activity
DOU31_RS06710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DOU31_RS06715	COG0328	RNA-DNA hybrid ribonuclease activity
DOU31_RS06725	COG1278	Cold shock
DOU31_RS06730	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DOU31_RS06740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DOU31_RS06745	COG0564	pseudouridine synthase activity
DOU31_RS06755	COG2233	PERMEase
DOU31_RS06760	COG0540	Belongs to the ATCase OTCase family
DOU31_RS06765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DOU31_RS06770	COG0505	Belongs to the CarA family
DOU31_RS06775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DOU31_RS06780	COG0543	2 iron, 2 sulfur cluster binding
DOU31_RS06785	COG0167	dihydroorotate dehydrogenase activity
DOU31_RS06790	COG0284	orotidine-5'-phosphate decarboxylase activity
DOU31_RS06805	COG0583	DNA-binding transcription factor activity
DOU31_RS06810	COG1609	Transcriptional regulator
DOU31_RS06820	COG0383	alpha-mannosidase activity
DOU31_RS06825	COG0436	Aminotransferase
DOU31_RS06835	COG5002	protein histidine kinase activity
DOU31_RS06840	COG0745	RESPONSE REGULATOR receiver
DOU31_RS06845	COG1683	Conserved Protein
DOU31_RS06850	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DOU31_RS06855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DOU31_RS06860	COG0789	Transcriptional regulator
DOU31_RS06865	COG0431	NADPH-dependent FMN reductase
DOU31_RS06870	COG1214	PFAM Peptidase M22, glycoprotease
DOU31_RS06870	COG0456	acetyltransferase
DOU31_RS06875	COG0228	four-way junction DNA binding
DOU31_RS06880	COG1837	Belongs to the UPF0109 family
DOU31_RS06890	COG1234	tRNA 3'-trailer cleavage
DOU31_RS06895	COG0300	oxidoreductase activity
DOU31_RS06900	COG5416	Lipopolysaccharide assembly protein A domain
DOU31_RS06905	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DOU31_RS06905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DOU31_RS06910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DOU31_RS06920	COG1272	protein, Hemolysin III
DOU31_RS06925	COG1307	EDD domain protein, DegV family
DOU31_RS06930	COG2755	lipolytic protein G-D-S-L family
DOU31_RS06935	COG4698	Protein conserved in bacteria
DOU31_RS06940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DOU31_RS06945	COG4479	Belongs to the UPF0346 family
DOU31_RS06950	COG0793	Belongs to the peptidase S41A family
DOU31_RS06950	COG3409	Peptidoglycan-binding domain 1 protein
DOU31_RS06955	COG0681	Belongs to the peptidase S26 family
DOU31_RS06970	COG1131	(ABC) transporter
DOU31_RS06980	COG1136	(ABC) transporter
DOU31_RS06985	COG0577	efflux transmembrane transporter activity
DOU31_RS06990	COG0604	alcohol dehydrogenase
DOU31_RS07000	COG0346	lactoylglutathione lyase activity
DOU31_RS07010	COG1028	Short-chain dehydrogenase reductase Sdr
DOU31_RS07030	COG0280	phosphate acetyltransferase
DOU31_RS07035	COG3426	butyrate kinase activity
DOU31_RS07040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DOU31_RS07045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DOU31_RS07050	COG0022	dehydrogenase e1 component
DOU31_RS07055	COG0508	dehydrogenase complex catalyzes the overall conversion of
DOU31_RS07065	COG0583	DNA-binding transcription factor activity
DOU31_RS07070	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DOU31_RS07100	COG1674	ftsk spoiiie
DOU31_RS07115	COG2946	Replication initiation factor
DOU31_RS07150	COG0741	lytic transglycosylase activity
DOU31_RS07150	COG0791	NLP P60 protein
DOU31_RS07165	COG3328	transposase activity
DOU31_RS07170	COG3328	transposase activity
DOU31_RS07180	COG1316	TRANSCRIPTIONal
DOU31_RS07185	COG3944	biosynthesis protein
DOU31_RS07190	COG0489	protein tyrosine kinase activity
DOU31_RS07195	COG4464	protein tyrosine phosphatase activity
DOU31_RS07205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DOU31_RS07215	COG0438	transferase activity, transferring glycosyl groups
DOU31_RS07260	COG4372	Transposase
DOU31_RS07305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DOU31_RS07310	COG0758	DNA mediated transformation
DOU31_RS07315	COG1266	CAAX protease self-immunity
DOU31_RS07320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DOU31_RS07325	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DOU31_RS07335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DOU31_RS07340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DOU31_RS07345	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DOU31_RS07355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DOU31_RS07360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DOU31_RS07365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOU31_RS07370	COG1120	ATPase activity
DOU31_RS07380	COG2096	Adenosyltransferase
DOU31_RS07410	COG4303	Ethanolamine ammonia lyase large subunit
DOU31_RS07415	COG4302	ethanolamine ammonia-lyase activity
DOU31_RS07430	COG1454	alcohol dehydrogenase
DOU31_RS07430	COG1012	belongs to the aldehyde dehydrogenase family
DOU31_RS07445	COG4869	propanediol catabolic process
DOU31_RS07455	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
DOU31_RS07460	COG3192	ethanolamine utilization protein
DOU31_RS07465	COG4766	ethanolamine catabolic process
DOU31_RS07470	COG1832	CoA-binding protein
DOU31_RS07475	COG0187	DNA topoisomerase II activity
DOU31_RS07480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DOU31_RS07485	COG1882	Formate acetyltransferase
DOU31_RS07490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DOU31_RS07495	COG1227	inorganic diphosphatase activity
DOU31_RS07505	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DOU31_RS07515	COG2190	(PTS) system
DOU31_RS07515	COG1263	PTS System
DOU31_RS07515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS07520	COG2723	6-phospho-beta-galactosidase activity
DOU31_RS07530	COG1609	Transcriptional regulator
DOU31_RS07540	COG0366	Alpha amylase catalytic
DOU31_RS07545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS07545	COG2190	(PTS) system
DOU31_RS07545	COG1263	PTS System
DOU31_RS07555	COG0415	Belongs to the DNA photolyase family
DOU31_RS07560	COG0753	catalase activity
DOU31_RS07580	COG1132	(ABC) transporter
DOU31_RS07585	COG1132	(ABC) transporter
DOU31_RS07590	COG2207	Transcriptional regulator
DOU31_RS07605	COG2816	NAD+ diphosphatase activity
DOU31_RS07610	COG0446	pyridine nucleotide-disulphide oxidoreductase
DOU31_RS07615	COG0735	belongs to the Fur family
DOU31_RS07625	COG1705	Flagellar rod assembly protein muramidase FlgJ
DOU31_RS07625	COG1388	LysM domain
DOU31_RS07630	COG2814	Major facilitator Superfamily
DOU31_RS07640	COG4224	UPF0291 protein
DOU31_RS07645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DOU31_RS07650	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DOU31_RS07660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DOU31_RS07665	COG0488	(ABC) transporter
DOU31_RS07690	COG1307	EDD domain protein, DegV family
DOU31_RS07700	COG0077	Prephenate dehydratase
DOU31_RS07705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DOU31_RS07715	COG0287	Prephenate dehydrogenase
DOU31_RS07720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DOU31_RS07730	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DOU31_RS07735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DOU31_RS07750	COG0617	tRNA 3'-terminal CCA addition
DOU31_RS07755	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DOU31_RS07760	COG1694	Mazg nucleotide pyrophosphohydrolase
DOU31_RS07765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOU31_RS07770	COG5582	Belongs to the UPF0302 family
DOU31_RS07775	COG0457	Tetratricopeptide repeat
DOU31_RS07795	COG1160	GTP binding
DOU31_RS07800	COG0539	negative regulation of cytoplasmic translation
DOU31_RS07805	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DOU31_RS07815	COG0514	ATP-dependent DNA helicase (RecQ)
DOU31_RS07835	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DOU31_RS07840	COG1187	pseudouridine synthase activity
DOU31_RS07845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DOU31_RS07850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DOU31_RS07855	COG4974	Belongs to the 'phage' integrase family
DOU31_RS07870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DOU31_RS07890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS07900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DOU31_RS07910	COG0735	belongs to the Fur family
DOU31_RS07915	COG2996	Protein conserved in bacteria
DOU31_RS07925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DOU31_RS07930	COG0358	DNA primase activity
DOU31_RS07935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DOU31_RS07940	COG0741	lytic transglycosylase activity
DOU31_RS07950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DOU31_RS07960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS07965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS07965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DOU31_RS07965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DOU31_RS07975	COG3711	transcriptional antiterminator
DOU31_RS07975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS07985	COG3711	transcriptional antiterminator
DOU31_RS07990	COG4166	transmembrane transport
DOU31_RS08000	COG4948	Mandelate Racemase Muconate Lactonizing
DOU31_RS08005	COG2151	metal-sulfur cluster biosynthetic enzyme
DOU31_RS08030	COG0019	diaminopimelate decarboxylase activity
DOU31_RS08035	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DOU31_RS08060	COG1394	ATPase activity, coupled to movement of substances
DOU31_RS08065	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
DOU31_RS08070	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
DOU31_RS08075	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
DOU31_RS08080	COG1527	subunit (C
DOU31_RS08085	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
DOU31_RS08090	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DOU31_RS08095	COG1269	ATP hydrolysis coupled proton transport
DOU31_RS08115	COG0166	Belongs to the GPI family
DOU31_RS08120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DOU31_RS08125	COG2081	HI0933 family
DOU31_RS08130	COG0488	(ABC) transporter
DOU31_RS08140	COG1486	melibiose metabolic process
DOU31_RS08145	COG1609	Transcriptional regulator
DOU31_RS08150	COG1668	transmembrane transport
DOU31_RS08155	COG4152	abc transporter atp-binding protein
DOU31_RS08170	COG0322	excinuclease ABC activity
DOU31_RS08175	COG3118	belongs to the thioredoxin family
DOU31_RS08180	COG1193	negative regulation of DNA recombination
DOU31_RS08185	COG1286	toxin biosynthetic process
DOU31_RS08205	COG2217	Heavy metal translocating P-type atpase
DOU31_RS08210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DOU31_RS08215	COG4149	molybdate abc transporter
DOU31_RS08220	COG0725	ABC transporter, periplasmic molybdate-binding protein
DOU31_RS08230	COG0521	Mo-molybdopterin cofactor biosynthetic process
DOU31_RS08245	COG0315	cyclic pyranopterin monophosphate synthase activity
DOU31_RS08255	COG0303	'Molybdopterin
DOU31_RS08260	COG3383	formate dehydrogenase (NAD+) activity
DOU31_RS08265	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DOU31_RS08280	COG2116	formate transmembrane transporter activity
DOU31_RS08285	COG0746	molybdenum cofactor guanylyltransferase activity
DOU31_RS08300	COG2195	Cleaves the N-terminal amino acid of tripeptides
DOU31_RS08305	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DOU31_RS08310	COG2384	SAM-dependent methyltransferase
DOU31_RS08315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DOU31_RS08325	COG0513	Belongs to the DEAD box helicase family
DOU31_RS08340	COG2824	Alkylphosphonate utilization operon protein PhnA
DOU31_RS08345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DOU31_RS08350	COG4109	DRTGG domain
DOU31_RS08355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DOU31_RS08360	COG2814	Major facilitator Superfamily
DOU31_RS08375	COG1278	Cold shock
DOU31_RS08385	COG0628	permease
DOU31_RS08395	COG3425	synthase
DOU31_RS08405	COG1461	Dihydroxyacetone kinase
DOU31_RS08410	COG2376	Dihydroxyacetone kinase
DOU31_RS08415	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DOU31_RS08420	COG0371	Dehydrogenase
DOU31_RS08450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DOU31_RS08465	COG0366	Alpha amylase catalytic
DOU31_RS08470	COG0366	Alpha amylase catalytic
DOU31_RS08475	COG0366	Alpha amylase catalytic
DOU31_RS08485	COG2182	Extracellular solute-binding protein
DOU31_RS08490	COG1175	transmembrane transport
DOU31_RS08495	COG3833	ABC-type maltose transport systems, permease component
DOU31_RS08505	COG1136	(ABC) transporter
DOU31_RS08505	COG0577	efflux transmembrane transporter activity
DOU31_RS08505	COG1136	(ABC) transporter
DOU31_RS08505	COG0577	efflux transmembrane transporter activity
DOU31_RS08520	COG0492	ferredoxin-NADP+ reductase activity
DOU31_RS08585	COG1674	ftsk spoiiie
DOU31_RS08590	COG4499	WXG100 protein secretion system (Wss), protein YukC
DOU31_RS08610	COG4842	Belongs to the WXG100 family
DOU31_RS08615	COG2188	Transcriptional regulator
DOU31_RS08625	COG1309	transcriptional regulator
DOU31_RS08650	COG2268	Band 7 protein
DOU31_RS08700	COG0436	Aminotransferase
DOU31_RS08720	COG3091	SprT-like family
DOU31_RS08725	COG2183	response to ionizing radiation
DOU31_RS08730	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DOU31_RS08735	COG0484	heat shock protein binding
DOU31_RS08745	COG0443	Heat shock 70 kDa protein
DOU31_RS08750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DOU31_RS08755	COG1420	regulation of RNA biosynthetic process
DOU31_RS08760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DOU31_RS08765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DOU31_RS08775	COG0583	DNA-binding transcription factor activity
DOU31_RS08780	COG0583	DNA-binding transcription factor activity
DOU31_RS08785	COG0772	Belongs to the SEDS family
DOU31_RS08800	COG1695	Transcriptional regulator
DOU31_RS08815	COG0196	riboflavin kinase activity
DOU31_RS08820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DOU31_RS08830	COG4824	toxin secretion phage lysis holin
DOU31_RS08925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DOU31_RS08930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DOU31_RS08940	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DOU31_RS08945	COG0195	Participates in both transcription termination and antitermination
DOU31_RS08950	COG0779	Required for maturation of 30S ribosomal subunits
DOU31_RS08955	COG1388	LysM domain
DOU31_RS08955	COG4932	domain protein
DOU31_RS08960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DOU31_RS08965	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DOU31_RS08975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DOU31_RS08980	COG1368	sulfuric ester hydrolase activity
DOU31_RS08995	COG3850	Histidine kinase
DOU31_RS08995	COG5002	protein histidine kinase activity
DOU31_RS09000	COG0745	RESPONSE REGULATOR receiver
DOU31_RS09005	COG0561	phosphatase activity
DOU31_RS09025	COG1122	ATPase activity
DOU31_RS09055	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DOU31_RS09070	COG2707	UPF0756 membrane protein
DOU31_RS09075	COG0673	inositol 2-dehydrogenase activity
DOU31_RS09080	COG2723	6-phospho-beta-galactosidase activity
DOU31_RS09085	COG2188	Transcriptional regulator
DOU31_RS09095	COG1609	Transcriptional regulator
DOU31_RS09100	COG3459	Glycosyltransferase 36 associated
DOU31_RS09115	COG3458	cephalosporin-C deacetylase activity
DOU31_RS09130	COG0395	ABC-type sugar transport system, permease component
DOU31_RS09135	COG4209	transmembrane transport
DOU31_RS09160	COG3976	FMN-binding domain protein
DOU31_RS09160	COG0431	NADPH-dependent FMN reductase
DOU31_RS09160	COG1053	succinate dehydrogenase
DOU31_RS09180	COG0402	S-adenosylhomocysteine deaminase activity
DOU31_RS09185	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DOU31_RS09195	COG3842	ATPase activity
DOU31_RS09205	COG1175	transmembrane transport
DOU31_RS09225	COG3527	Alpha-acetolactate decarboxylase
DOU31_RS09230	COG0028	Belongs to the TPP enzyme family
DOU31_RS09235	COG1316	TRANSCRIPTIONal
DOU31_RS09240	COG0446	pyridine nucleotide-disulphide oxidoreductase
DOU31_RS09245	COG4565	transcriptional regulatory protein
DOU31_RS09250	COG3290	protein histidine kinase activity
DOU31_RS09255	COG3493	citrate carrier protein
DOU31_RS09270	COG3906	Belongs to the UPF0473 family
DOU31_RS09275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DOU31_RS09280	COG4472	Bacterial protein of unknown function (DUF965)
DOU31_RS09295	COG3689	TIGRFAM TIGR03943 family protein
DOU31_RS09300	COG0701	Predicted permease
DOU31_RS09305	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DOU31_RS09320	COG5002	protein histidine kinase activity
DOU31_RS09325	COG0745	RESPONSE REGULATOR receiver
DOU31_RS09330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DOU31_RS09335	COG1307	EDD domain protein, DegV family
DOU31_RS09350	COG0647	UMP catabolic process
DOU31_RS09355	COG4470	Protein conserved in bacteria
DOU31_RS09360	COG0737	Belongs to the 5'-nucleotidase family
DOU31_RS09370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DOU31_RS09375	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DOU31_RS09380	COG1854	S-ribosylhomocysteine lyase activity
DOU31_RS09390	COG3237	CsbD-like
DOU31_RS09395	COG1940	carbohydrate kinase activity
DOU31_RS09410	COG0254	rRNA binding
DOU31_RS09415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DOU31_RS09420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DOU31_RS09430	COG0191	fructose-bisphosphate aldolase activity
DOU31_RS09435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DOU31_RS09440	COG1666	GTP binding
DOU31_RS09465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS09470	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS09475	COG1446	asparaginase
DOU31_RS09485	COG2188	Transcriptional regulator
DOU31_RS09490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DOU31_RS09495	COG3935	DnaD domain protein
DOU31_RS09500	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DOU31_RS09505	COG0116	Belongs to the methyltransferase superfamily
DOU31_RS09515	COG3599	regulation of cell shape
DOU31_RS09520	COG4474	Belongs to the UPF0398 family
DOU31_RS09525	COG3331	DNA recombination
DOU31_RS09530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOU31_RS09535	COG0504	CTP synthase activity
DOU31_RS09550	COG0095	Lipoate-protein ligase
DOU31_RS09555	COG1078	dGTPase activity
DOU31_RS09560	COG0561	phosphatase activity
DOU31_RS09575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DOU31_RS09580	COG0656	L-ascorbic acid biosynthetic process
DOU31_RS09595	COG0668	transmembrane transport
DOU31_RS09600	COG1473	amidohydrolase
DOU31_RS09605	COG2171	N-acyltransferase activity
DOU31_RS09610	COG0517	IMP dehydrogenase activity
DOU31_RS09620	COG3623	hexulose-6-phosphate isomerase
DOU31_RS09625	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DOU31_RS09635	COG3037	sugar-specific permease SgaT UlaA
DOU31_RS09640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS09650	COG1349	DNA-binding transcription factor activity
DOU31_RS09655	COG0622	Phosphoesterase
DOU31_RS09660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DOU31_RS09665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DOU31_RS09675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOU31_RS09680	COG0765	amino acid transport
DOU31_RS09685	COG0765	amino acid transport
DOU31_RS09690	COG0072	phenylalanine-tRNA ligase activity
DOU31_RS09690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOU31_RS09695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DOU31_RS09700	COG1733	regulation of RNA biosynthetic process
DOU31_RS09705	COG1074	ATP-dependent DNA helicase activity
DOU31_RS09710	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DOU31_RS09725	COG1139	Iron-sulfur cluster binding protein
DOU31_RS09730	COG0247	lactate metabolic process
DOU31_RS09750	COG1113	amino acid transport
DOU31_RS09765	COG1132	(ABC) transporter
DOU31_RS09860	COG0456	acetyltransferase
DOU31_RS09890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DOU31_RS09900	COG2814	Major facilitator Superfamily
DOU31_RS09920	COG0572	uridine kinase
DOU31_RS09925	COG1609	Transcriptional regulator
DOU31_RS09930	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DOU31_RS09935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DOU31_RS09940	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DOU31_RS09955	COG0110	maltose O-acetyltransferase activity
DOU31_RS09970	COG1956	GAF domain-containing protein
DOU31_RS09975	COG0402	S-adenosylhomocysteine deaminase activity
DOU31_RS09980	COG0402	S-adenosylhomocysteine deaminase activity
DOU31_RS09985	COG4166	transmembrane transport
DOU31_RS09990	COG2508	Transcriptional regulator
DOU31_RS10000	COG1914	H( )-stimulated, divalent metal cation uptake system
DOU31_RS10010	COG1660	Displays ATPase and GTPase activities
DOU31_RS10015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DOU31_RS10020	COG1116	anion transmembrane transporter activity
DOU31_RS10120	COG5002	protein histidine kinase activity
DOU31_RS10125	COG0745	RESPONSE REGULATOR receiver
DOU31_RS10130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DOU31_RS10135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DOU31_RS10150	COG0205	6-phosphofructokinase activity
DOU31_RS10155	COG0587	DNA-directed DNA polymerase activity
DOU31_RS10165	COG2814	Major facilitator Superfamily
DOU31_RS10175	COG2252	PERMEase
DOU31_RS10185	COG0561	phosphatase activity
DOU31_RS10200	COG0105	UTP biosynthetic process
DOU31_RS10240	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DOU31_RS10240	COG0392	lysyltransferase activity
DOU31_RS10245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DOU31_RS10250	COG0517	IMP dehydrogenase activity
DOU31_RS10255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DOU31_RS10255	COG0574	Belongs to the PEP-utilizing enzyme family
DOU31_RS10280	COG2723	6-phospho-beta-galactosidase activity
DOU31_RS10285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS10290	COG1447	Phosphotransferase system cellobiose-specific component IIA
DOU31_RS10295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS10315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS10320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS10325	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DOU31_RS10325	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DOU31_RS10335	COG0673	inositol 2-dehydrogenase activity
DOU31_RS10355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DOU31_RS10360	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DOU31_RS10365	COG3599	regulation of cell shape
DOU31_RS10370	COG2302	S4 RNA-binding domain
DOU31_RS10375	COG0762	integral membrane protein
DOU31_RS10380	COG1799	cell septum assembly
DOU31_RS10385	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DOU31_RS10390	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DOU31_RS10395	COG0849	cell division
DOU31_RS10405	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DOU31_RS10410	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DOU31_RS10415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DOU31_RS10420	COG0768	penicillin binding
DOU31_RS10430	COG0275	rRNA processing
DOU31_RS10435	COG2001	Belongs to the MraZ family
DOU31_RS10460	COG0497	DNA recombination
DOU31_RS10465	COG1438	arginine binding
DOU31_RS10470	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DOU31_RS10475	COG0142	geranyltranstransferase activity
DOU31_RS10480	COG1722	exodeoxyribonuclease VII activity
DOU31_RS10485	COG1570	exodeoxyribonuclease VII activity
DOU31_RS10490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DOU31_RS10495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DOU31_RS10500	COG1302	Protein conserved in bacteria
DOU31_RS10505	COG1694	Mazg nucleotide pyrophosphohydrolase
DOU31_RS10510	COG0006	proline dipeptidase activity
DOU31_RS10515	COG1408	metallophosphoesterase
DOU31_RS10520	COG3223	Belongs to the PsiE family
DOU31_RS10525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DOU31_RS10535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DOU31_RS10615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DOU31_RS10630	COG2190	(PTS) system
DOU31_RS10630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS10630	COG1263	PTS System
DOU31_RS10640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOU31_RS10645	COG2017	converts alpha-aldose to the beta-anomer
DOU31_RS10650	COG1609	Transcriptional regulator
DOU31_RS10665	COG0802	atpase or kinase
DOU31_RS10670	COG0280	phosphate acetyltransferase
DOU31_RS10675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DOU31_RS10680	COG0561	phosphatase activity
DOU31_RS10695	COG3584	3D domain protein
DOU31_RS10710	COG1132	(ABC) transporter
DOU31_RS10715	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DOU31_RS10720	COG1803	Methylglyoxal synthase
DOU31_RS10725	COG3842	ATPase activity
DOU31_RS10735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DOU31_RS10740	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DOU31_RS10745	COG0084	hydrolase, TatD family'
DOU31_RS10750	COG3973	AAA domain
DOU31_RS10765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOU31_RS10765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DOU31_RS10770	COG0531	amino acid
DOU31_RS10775	COG4975	Glucose uptake
DOU31_RS10780	COG2205	protein histidine kinase activity
DOU31_RS10785	COG0745	RESPONSE REGULATOR receiver
DOU31_RS10805	COG2855	membrane
DOU31_RS10810	COG0659	secondary active sulfate transmembrane transporter activity
DOU31_RS10815	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DOU31_RS10815	COG0456	acetyltransferase
DOU31_RS10825	COG3759	membrane
DOU31_RS10835	COG2315	Protein conserved in bacteria
DOU31_RS10840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DOU31_RS10845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DOU31_RS10850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DOU31_RS10860	COG4608	Belongs to the ABC transporter superfamily
DOU31_RS10865	COG0444	Belongs to the ABC transporter superfamily
DOU31_RS10870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DOU31_RS10875	COG0601	transmembrane transport
DOU31_RS10885	COG4166	transmembrane transport
DOU31_RS10920	COG1304	FMN binding
DOU31_RS10925	COG1012	belongs to the aldehyde dehydrogenase family
DOU31_RS10925	COG1454	alcohol dehydrogenase
DOU31_RS10940	COG1862	Preprotein translocase
DOU31_RS10945	COG0343	queuine tRNA-ribosyltransferase activity
DOU31_RS10950	COG0371	Dehydrogenase
DOU31_RS10955	COG0765	amino acid transport
DOU31_RS10960	COG1126	abc transporter atp-binding protein
DOU31_RS11005	COG1484	DNA-dependent DNA replication
DOU31_RS11010	COG3611	Membrane attachment protein
DOU31_RS11015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DOU31_RS11020	COG0237	dephospho-CoA kinase activity
DOU31_RS11025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DOU31_RS11030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOU31_RS11030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DOU31_RS11035	COG4989	oxidoreductase activity
DOU31_RS11045	COG2217	Heavy metal translocating P-type atpase
DOU31_RS11055	COG3158	transport of potassium into the cell
DOU31_RS11075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DOU31_RS11080	COG0346	lactoylglutathione lyase activity
DOU31_RS11100	COG1174	glycine betaine transport
DOU31_RS11110	COG0531	amino acid
DOU31_RS11130	COG2365	Tyrosine phosphatase family
DOU31_RS11140	COG0681	Belongs to the peptidase S26 family
DOU31_RS11160	COG2337	Toxic component of a toxin-antitoxin (TA) module
DOU31_RS11165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DOU31_RS11170	COG0736	holo-[acyl-carrier-protein] synthase activity
DOU31_RS11190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DOU31_RS11195	COG1181	Belongs to the D-alanine--D-alanine ligase family
DOU31_RS11200	COG1671	Belongs to the UPF0178 family
DOU31_RS11205	COG0187	DNA topoisomerase II activity
DOU31_RS11225	COG3964	amidohydrolase
DOU31_RS11240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS11270	COG3711	transcriptional antiterminator
DOU31_RS11275	COG0673	inositol 2-dehydrogenase activity
DOU31_RS11280	COG2337	Toxic component of a toxin-antitoxin (TA) module
DOU31_RS11295	COG1011	Hydrolase
DOU31_RS11300	COG1187	pseudouridine synthase activity
DOU31_RS11310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DOU31_RS11335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS11335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS11340	COG2188	Transcriptional regulator
DOU31_RS11350	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DOU31_RS11375	COG4166	transmembrane transport
DOU31_RS11380	COG0765	amino acid transport
DOU31_RS11385	COG1126	abc transporter atp-binding protein
DOU31_RS11390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOU31_RS11395	COG3177	Filamentation induced by cAMP protein fic
DOU31_RS11410	COG0495	leucyl-tRNA aminoacylation
DOU31_RS11415	COG1388	LysM domain
DOU31_RS11415	COG1705	Flagellar rod assembly protein muramidase FlgJ
DOU31_RS11430	COG0671	phosphoesterase, PA-phosphatase related
DOU31_RS11435	COG1242	4 iron, 4 sulfur cluster binding
DOU31_RS11440	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DOU31_RS11445	COG1136	(ABC) transporter
DOU31_RS11450	COG0577	efflux transmembrane transporter activity
DOU31_RS11455	COG1309	transcriptional regulator
DOU31_RS11470	COG1132	(ABC) transporter
DOU31_RS11475	COG1132	(ABC) transporter
DOU31_RS11490	COG0477	Major facilitator Superfamily
DOU31_RS11495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DOU31_RS11505	COG1122	ATPase activity
DOU31_RS11510	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DOU31_RS11510	COG2755	lipolytic protein G-D-S-L family
DOU31_RS11515	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DOU31_RS11525	COG1278	Cold shock
DOU31_RS11530	COG2816	NAD+ diphosphatase activity
DOU31_RS11535	COG0584	glycerophosphoryl diester phosphodiesterase
DOU31_RS11565	COG0740	serine-type endopeptidase activity
DOU31_RS11580	COG1481	regulation of sporulation
DOU31_RS11590	COG1660	Displays ATPase and GTPase activities
DOU31_RS11600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DOU31_RS11605	COG0556	nucleotide-excision repair
DOU31_RS11610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DOU31_RS11620	COG1285	pathogenesis
DOU31_RS11625	COG2217	Heavy metal translocating P-type atpase
DOU31_RS11670	COG1054	Belongs to the UPF0176 family
DOU31_RS11680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DOU31_RS11710	COG1428	Deoxynucleoside kinase
DOU31_RS11725	COG0154	amidase activity
DOU31_RS11730	COG0549	Belongs to the carbamate kinase family
DOU31_RS11740	COG0531	amino acid
DOU31_RS11745	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DOU31_RS11750	COG2197	response regulator
DOU31_RS11760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DOU31_RS11765	COG1597	lipid kinase activity
DOU31_RS11770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DOU31_RS11775	COG0154	amidase activity
DOU31_RS11780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DOU31_RS11790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DOU31_RS11795	COG0210	DNA helicase
DOU31_RS11805	COG1349	DNA-binding transcription factor activity
DOU31_RS11810	COG1105	Belongs to the carbohydrate kinase PfkB family
DOU31_RS11815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS11815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DOU31_RS11815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DOU31_RS11825	COG0544	peptidyl-prolyl cis-trans isomerase activity
DOU31_RS11845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DOU31_RS11850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS11865	COG0542	response to heat
DOU31_RS11890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DOU31_RS11895	COG1253	flavin adenine dinucleotide binding
DOU31_RS11900	COG0628	permease
DOU31_RS11910	COG3557	Belongs to the UPF0374 family
DOU31_RS11915	COG3684	Belongs to the aldolase LacD family
DOU31_RS11925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS11925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DOU31_RS11925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DOU31_RS11940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DOU31_RS11945	COG0510	thiamine kinase activity
DOU31_RS11950	COG4473	ABC transporter
DOU31_RS11955	COG1131	(ABC) transporter
DOU31_RS11960	COG0537	adenosine 5'-monophosphoramidase activity
DOU31_RS11970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DOU31_RS11975	COG3481	metal-dependent phosphohydrolase, HD sub domain
DOU31_RS11990	COG3679	Belongs to the UPF0342 family
DOU31_RS11995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DOU31_RS12000	COG0564	pseudouridine synthase activity
DOU31_RS12010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DOU31_RS12015	COG1438	arginine binding
DOU31_RS12020	COG1732	Glycine betaine
DOU31_RS12025	COG1125	glycine betaine transport
DOU31_RS12025	COG0517	IMP dehydrogenase activity
DOU31_RS12030	COG3594	Acyltransferase
DOU31_RS12045	COG1187	pseudouridine synthase activity
DOU31_RS12050	COG2244	polysaccharide biosynthetic process
DOU31_RS12055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DOU31_RS12065	COG0346	lactoylglutathione lyase activity
DOU31_RS12080	COG0217	transcriptional regulatory protein
DOU31_RS12095	COG0534	Mate efflux family protein
DOU31_RS12110	COG1349	DNA-binding transcription factor activity
DOU31_RS12115	COG2514	catechol 2,3-dioxygenase activity
DOU31_RS12125	COG1609	Transcriptional regulator
DOU31_RS12145	COG0095	Lipoate-protein ligase
DOU31_RS12150	COG0778	Nitroreductase
DOU31_RS12155	COG1733	regulation of RNA biosynthetic process
DOU31_RS12170	COG0583	DNA-binding transcription factor activity
DOU31_RS12185	COG0039	L-malate dehydrogenase activity
DOU31_RS12195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DOU31_RS12210	COG1757	Na H antiporter
DOU31_RS12215	COG1113	amino acid transport
DOU31_RS12230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DOU31_RS12240	COG0656	L-ascorbic acid biosynthetic process
DOU31_RS12255	COG1263	PTS System
DOU31_RS12255	COG2190	(PTS) system
DOU31_RS12255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS12260	COG2190	(PTS) system
DOU31_RS12260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS12260	COG1263	PTS System
DOU31_RS12265	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DOU31_RS12295	COG2723	6-phospho-beta-galactosidase activity
DOU31_RS12300	COG1263	PTS System
DOU31_RS12300	COG2190	(PTS) system
DOU31_RS12300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS12305	COG3711	transcriptional antiterminator
DOU31_RS12330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DOU31_RS12355	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DOU31_RS12410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DOU31_RS12415	COG1780	Probably involved in ribonucleotide reductase function
DOU31_RS12420	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DOU31_RS12440	COG1285	pathogenesis
DOU31_RS12445	COG0363	glucosamine-6-phosphate deaminase activity
DOU31_RS12450	COG1316	TRANSCRIPTIONal
DOU31_RS12455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DOU31_RS12460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DOU31_RS12475	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DOU31_RS12480	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DOU31_RS12490	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS12495	COG3716	PTS system mannose fructose sorbose family IID component
DOU31_RS12510	COG1764	response to oxidative stress
DOU31_RS12515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DOU31_RS12520	COG0363	glucosamine-6-phosphate deaminase activity
DOU31_RS12525	COG4948	Mandelate Racemase Muconate Lactonizing
DOU31_RS12530	COG2267	carboxylic ester hydrolase activity
DOU31_RS12535	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DOU31_RS12540	COG1169	isochorismate synthase
DOU31_RS12545	COG0318	PFAM AMP-dependent synthetase and ligase
DOU31_RS12550	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DOU31_RS12560	COG1388	LysM domain
DOU31_RS12560	COG3942	CHAP domain
DOU31_RS12575	COG3104	oligopeptide transport
DOU31_RS12585	COG1028	Short-chain dehydrogenase reductase Sdr
DOU31_RS12590	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DOU31_RS12600	COG0800	Aldolase
DOU31_RS12610	COG1414	Transcriptional regulator
DOU31_RS12620	COG2814	Major facilitator Superfamily
DOU31_RS12640	COG0577	efflux transmembrane transporter activity
DOU31_RS12645	COG0577	efflux transmembrane transporter activity
DOU31_RS12645	COG1136	(ABC) transporter
DOU31_RS12660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DOU31_RS12665	COG0246	Mannitol dehydrogenase
DOU31_RS12670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS12675	COG2213	PTS system mannitol-specific
DOU31_RS12685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS12690	COG3711	transcriptional antiterminator
DOU31_RS12695	COG2213	PTS system mannitol-specific
DOU31_RS12705	COG0561	phosphatase activity
DOU31_RS12710	COG0778	Nitroreductase
DOU31_RS12715	COG1846	Transcriptional regulator
DOU31_RS12720	COG1757	Na H antiporter
DOU31_RS12725	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DOU31_RS12750	COG0628	permease
DOU31_RS12755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DOU31_RS12790	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DOU31_RS12800	COG0549	Belongs to the carbamate kinase family
DOU31_RS12815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DOU31_RS12820	COG3835	regulator
DOU31_RS12845	COG0666	response to abiotic stimulus
DOU31_RS12860	COG5002	protein histidine kinase activity
DOU31_RS12865	COG0745	RESPONSE REGULATOR receiver
DOU31_RS12870	COG1104	cysteine desulfurase activity
DOU31_RS12875	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DOU31_RS12880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DOU31_RS12885	COG0527	aspartate kinase activity
DOU31_RS12895	COG1801	Protein of unknown function DUF72
DOU31_RS12905	COG3397	chitin binding
DOU31_RS12910	COG3469	chitinase activity
DOU31_RS12915	COG2076	Multidrug Resistance protein
DOU31_RS12920	COG2076	Multidrug Resistance protein
DOU31_RS12925	COG0346	lactoylglutathione lyase activity
DOU31_RS12930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DOU31_RS12940	COG3579	cysteine-type endopeptidase activity
DOU31_RS12945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DOU31_RS12960	COG2217	Heavy metal translocating P-type atpase
DOU31_RS12975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DOU31_RS12980	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DOU31_RS12990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DOU31_RS12995	COG2723	6-phospho-beta-galactosidase activity
DOU31_RS13000	COG0626	cystathionine gamma-synthase activity
DOU31_RS13005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DOU31_RS13015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DOU31_RS13030	COG0167	dihydroorotate dehydrogenase activity
DOU31_RS13035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DOU31_RS13040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DOU31_RS13045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DOU31_RS13060	COG1418	mRNA catabolic process
DOU31_RS13065	COG0519	Catalyzes the synthesis of GMP from XMP
DOU31_RS13070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DOU31_RS13075	COG2169	Transcriptional regulator
DOU31_RS13080	COG0596	Alpha beta hydrolase
DOU31_RS13090	COG2723	6-phospho-beta-galactosidase activity
DOU31_RS13095	COG2723	6-phospho-beta-galactosidase activity
DOU31_RS13100	COG2190	(PTS) system
DOU31_RS13100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS13100	COG1263	PTS System
DOU31_RS13105	COG3711	transcriptional antiterminator
DOU31_RS13260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DOU31_RS13265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DOU31_RS13270	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DOU31_RS13275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DOU31_RS13280	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DOU31_RS13285	COG0037	tRNA processing
DOU31_RS13290	COG1098	S1 RNA binding domain
DOU31_RS13305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DOU31_RS13310	COG2244	polysaccharide biosynthetic process
DOU31_RS13315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DOU31_RS13320	COG0193	aminoacyl-tRNA hydrolase activity
DOU31_RS13325	COG0039	L-malate dehydrogenase activity
DOU31_RS13340	COG3942	CHAP domain
DOU31_RS13340	COG1705	Flagellar rod assembly protein muramidase FlgJ
DOU31_RS13345	COG1827	regulation of RNA biosynthetic process
DOU31_RS13350	COG0110	maltose O-acetyltransferase activity
DOU31_RS13355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DOU31_RS13365	COG0765	amino acid transport
DOU31_RS13370	COG1126	abc transporter atp-binding protein
DOU31_RS13385	COG1114	Component of the transport system for branched-chain amino acids
DOU31_RS13390	COG0393	Putative heavy-metal-binding
DOU31_RS13405	COG1122	ATPase activity
DOU31_RS13410	COG1122	ATPase activity
DOU31_RS13415	COG1473	amidohydrolase
DOU31_RS13430	COG0203	ribosomal protein L17
DOU31_RS13435	COG0202	RNA polymerase activity
DOU31_RS13440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DOU31_RS13445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DOU31_RS13450	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DOU31_RS13455	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DOU31_RS13460	COG0563	adenylate kinase activity
DOU31_RS13465	COG0201	protein transport
DOU31_RS13470	COG0200	Binds to the 23S rRNA
DOU31_RS13475	COG1841	ribosomal large subunit assembly
DOU31_RS13480	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DOU31_RS13485	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DOU31_RS13490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DOU31_RS13495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DOU31_RS13500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DOU31_RS13505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DOU31_RS13510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DOU31_RS13515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DOU31_RS13520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DOU31_RS13525	COG0255	Belongs to the universal ribosomal protein uL29 family
DOU31_RS13530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DOU31_RS13535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DOU31_RS13540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DOU31_RS13545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DOU31_RS13550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DOU31_RS13555	COG0089	rRNA binding
DOU31_RS13560	COG0088	Forms part of the polypeptide exit tunnel
DOU31_RS13565	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DOU31_RS13570	COG0051	transcription antitermination factor activity, RNA binding
DOU31_RS13575	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DOU31_RS13580	COG0351	phosphomethylpyrimidine kinase
DOU31_RS13585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DOU31_RS13590	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DOU31_RS13595	COG0049	tRNA binding
DOU31_RS13600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DOU31_RS13610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DOU31_RS13615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DOU31_RS13620	COG0588	phosphoglycerate mutase activity
DOU31_RS13625	COG1979	alcohol dehydrogenase
DOU31_RS13630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOU31_RS13635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DOU31_RS13640	COG1120	ATPase activity
DOU31_RS13645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DOU31_RS13650	COG0813	purine-nucleoside phosphorylase activity
DOU31_RS13660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DOU31_RS13680	COG1079	Belongs to the binding-protein-dependent transport system permease family
DOU31_RS13685	COG4603	Belongs to the binding-protein-dependent transport system permease family
DOU31_RS13690	COG3845	ABC transporter
DOU31_RS13695	COG1744	ABC transporter substrate-binding protein PnrA-like
DOU31_RS13700	COG1744	ABC transporter substrate-binding protein PnrA-like
DOU31_RS13705	COG0295	cytidine deaminase activity
DOU31_RS13710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DOU31_RS13715	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DOU31_RS13720	COG1609	Transcriptional regulator
DOU31_RS13725	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DOU31_RS13730	COG2813	Specifically methylates the guanine in position
DOU31_RS13740	COG1072	(Pantothenic acid kinase))
DOU31_RS13745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DOU31_RS13745	COG0519	Catalyzes the synthesis of GMP from XMP
DOU31_RS13805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DOU31_RS13815	COG0251	oxidation-reduction process
DOU31_RS13825	COG0604	alcohol dehydrogenase
DOU31_RS13830	COG0640	Transcriptional regulator
DOU31_RS13840	COG1288	antiporter activity
DOU31_RS13850	COG0549	Belongs to the carbamate kinase family
DOU31_RS13855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DOU31_RS13860	COG2235	arginine
DOU31_RS13865	COG1438	arginine binding
DOU31_RS13870	COG1438	arginine binding
DOU31_RS13880	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DOU31_RS13885	COG1760	l-serine dehydratase
DOU31_RS13890	COG1760	l-serine dehydratase
DOU31_RS13900	COG2964	Protein conserved in bacteria
DOU31_RS13910	COG2116	formate transmembrane transporter activity
DOU31_RS13935	COG1597	lipid kinase activity
DOU31_RS13970	COG2814	Major facilitator Superfamily
DOU31_RS13995	COG2261	transglycosylase associated protein
DOU31_RS14020	COG1028	Short-chain dehydrogenase reductase Sdr
DOU31_RS14025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DOU31_RS14035	COG3408	Glycogen debranching enzyme
DOU31_RS14035	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DOU31_RS14040	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DOU31_RS14045	COG2255	four-way junction helicase activity
DOU31_RS14050	COG0632	four-way junction helicase activity
DOU31_RS14055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DOU31_RS14060	COG4224	UPF0291 protein
DOU31_RS14065	COG4166	transmembrane transport
DOU31_RS14070	COG0737	Belongs to the 5'-nucleotidase family
DOU31_RS14075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DOU31_RS14080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DOU31_RS14085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DOU31_RS14090	COG1121	(ABC) transporter
DOU31_RS14095	COG0803	Belongs to the bacterial solute-binding protein 9 family
DOU31_RS14095	COG3443	Belongs to the bacterial solute-binding protein 9 family
DOU31_RS14105	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DOU31_RS14110	COG4466	Protein conserved in bacteria
DOU31_RS14120	COG3688	RNA-binding protein containing a PIN domain
DOU31_RS14125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DOU31_RS14130	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DOU31_RS14135	COG0215	cysteine-tRNA ligase activity
DOU31_RS14140	COG1045	serine acetyltransferase
DOU31_RS14150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DOU31_RS14155	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DOU31_RS14160	COG4956	integral membrane protein (PIN domain superfamily)
DOU31_RS14170	COG0756	dUTP diphosphatase activity
DOU31_RS14175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DOU31_RS14180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DOU31_RS14210	COG0392	lysyltransferase activity
DOU31_RS14210	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DOU31_RS14215	COG0251	oxidation-reduction process
DOU31_RS14220	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DOU31_RS14230	COG1737	Transcriptional regulator
DOU31_RS14255	COG3716	PTS system mannose fructose sorbose family IID component
DOU31_RS14260	COG3715	PTS system
DOU31_RS14270	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DOU31_RS14270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DOU31_RS14275	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DOU31_RS14275	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DOU31_RS14280	COG0488	(ABC) transporter
DOU31_RS14290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DOU31_RS14295	COG0305	Participates in initiation and elongation during chromosome replication
DOU31_RS14300	COG0359	binds to the 23S rRNA
DOU31_RS14310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DOU31_RS14315	COG0629	single-stranded DNA binding
DOU31_RS14320	COG0360	Binds together with S18 to 16S ribosomal RNA
DOU31_RS14330	COG0187	DNA topoisomerase II activity
DOU31_RS14335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DOU31_RS14340	COG2501	S4 domain
DOU31_RS14345	COG0592	DNA-directed DNA polymerase activity
DOU31_RS14430	COG2184	nucleotidyltransferase activity
DOU31_RS14465	COG0488	(ABC) transporter
DOU31_RS14480	COG0477	Major facilitator Superfamily
DOU31_RS14485	COG2003	Belongs to the UPF0758 family
DOU31_RS14515	COG3843	relaxase mobilization nuclease domain protein
DOU31_RS14585	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DOU31_RS14610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DOU31_RS14635	COG1192	Involved in chromosome partitioning
DOU31_RS14650	COG0210	DNA helicase
DOU31_RS14665	COG0563	adenylate kinase activity
DOU31_RS14670	COG2217	Heavy metal translocating P-type atpase
DOU31_RS14675	COG2217	Heavy metal translocating P-type atpase
DOU31_RS14685	COG3682	Transcriptional regulator
DOU31_RS14710	COG1388	LysM domain
DOU31_RS14725	COG0745	RESPONSE REGULATOR receiver
DOU31_RS14730	COG2132	Multicopper oxidase
DOU31_RS14750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DOU31_RS14785	COG3843	relaxase mobilization nuclease domain protein
DOU31_RS14820	COG0629	single-stranded DNA binding
DOU31_RS15000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DOU31_RS15055	COG2184	nucleotidyltransferase activity
DOU31_RS15105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid