locus-tag	class	description
EGM183_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGM183_RS00010	COG0592	DNA-directed DNA polymerase activity
EGM183_RS00015	COG2501	S4 domain
EGM183_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EGM183_RS00025	COG0187	DNA topoisomerase II activity
EGM183_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
EGM183_RS00040	COG0629	single-stranded DNA binding
EGM183_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EGM183_RS00055	COG0359	binds to the 23S rRNA
EGM183_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
EGM183_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EGM183_RS00075	COG0488	(ABC) transporter
EGM183_RS00080	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EGM183_RS00080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EGM183_RS00085	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM183_RS00085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS00095	COG3715	PTS system
EGM183_RS00100	COG3716	PTS system mannose fructose sorbose family IID component
EGM183_RS00120	COG1737	Transcriptional regulator
EGM183_RS00125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS00125	COG1263	PTS System
EGM183_RS00130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EGM183_RS00135	COG0251	oxidation-reduction process
EGM183_RS00140	COG0392	lysyltransferase activity
EGM183_RS00140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EGM183_RS00165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EGM183_RS00170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EGM183_RS00175	COG0756	dUTP diphosphatase activity
EGM183_RS00185	COG4956	integral membrane protein (PIN domain superfamily)
EGM183_RS00190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EGM183_RS00195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGM183_RS00200	COG1045	serine acetyltransferase
EGM183_RS00205	COG0215	cysteine-tRNA ligase activity
EGM183_RS00210	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EGM183_RS00215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGM183_RS00220	COG3688	RNA-binding protein containing a PIN domain
EGM183_RS00230	COG4466	Protein conserved in bacteria
EGM183_RS00235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EGM183_RS00240	COG3443	Belongs to the bacterial solute-binding protein 9 family
EGM183_RS00240	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGM183_RS00245	COG1121	(ABC) transporter
EGM183_RS00250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGM183_RS00255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGM183_RS00260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EGM183_RS00265	COG0737	Belongs to the 5'-nucleotidase family
EGM183_RS00270	COG4166	transmembrane transport
EGM183_RS00275	COG4224	UPF0291 protein
EGM183_RS00280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EGM183_RS00290	COG0632	four-way junction helicase activity
EGM183_RS00295	COG2255	four-way junction helicase activity
EGM183_RS00300	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EGM183_RS00315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGM183_RS00320	COG1028	Short-chain dehydrogenase reductase Sdr
EGM183_RS00345	COG2261	transglycosylase associated protein
EGM183_RS00380	COG2814	Major facilitator Superfamily
EGM183_RS00405	COG1597	lipid kinase activity
EGM183_RS00425	COG2116	formate transmembrane transporter activity
EGM183_RS00435	COG2964	Protein conserved in bacteria
EGM183_RS00445	COG1760	l-serine dehydratase
EGM183_RS00450	COG1760	l-serine dehydratase
EGM183_RS00455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EGM183_RS00465	COG1438	arginine binding
EGM183_RS00470	COG1438	arginine binding
EGM183_RS00475	COG2235	arginine
EGM183_RS00480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EGM183_RS00485	COG0549	Belongs to the carbamate kinase family
EGM183_RS00495	COG1288	antiporter activity
EGM183_RS00505	COG0640	Transcriptional regulator
EGM183_RS00510	COG0604	alcohol dehydrogenase
EGM183_RS00520	COG0251	oxidation-reduction process
EGM183_RS00530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGM183_RS00535	COG2423	ornithine cyclodeaminase activity
EGM183_RS00580	COG0519	Catalyzes the synthesis of GMP from XMP
EGM183_RS00580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGM183_RS00585	COG1072	(Pantothenic acid kinase))
EGM183_RS00595	COG2813	Specifically methylates the guanine in position
EGM183_RS00600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EGM183_RS00605	COG1609	Transcriptional regulator
EGM183_RS00610	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EGM183_RS00615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EGM183_RS00620	COG0295	cytidine deaminase activity
EGM183_RS00625	COG1744	ABC transporter substrate-binding protein PnrA-like
EGM183_RS00630	COG1744	ABC transporter substrate-binding protein PnrA-like
EGM183_RS00635	COG3845	ABC transporter
EGM183_RS00640	COG4603	Belongs to the binding-protein-dependent transport system permease family
EGM183_RS00645	COG1079	Belongs to the binding-protein-dependent transport system permease family
EGM183_RS00660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EGM183_RS00675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EGM183_RS00680	COG1120	ATPase activity
EGM183_RS00685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGM183_RS00690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGM183_RS00695	COG1979	alcohol dehydrogenase
EGM183_RS00700	COG0588	phosphoglycerate mutase activity
EGM183_RS00705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EGM183_RS00710	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EGM183_RS00715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EGM183_RS00720	COG0049	tRNA binding
EGM183_RS00725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGM183_RS00730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EGM183_RS00735	COG0351	phosphomethylpyrimidine kinase
EGM183_RS00740	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EGM183_RS00745	COG0051	transcription antitermination factor activity, RNA binding
EGM183_RS00750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EGM183_RS00755	COG0088	Forms part of the polypeptide exit tunnel
EGM183_RS00760	COG0089	rRNA binding
EGM183_RS00765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EGM183_RS00770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EGM183_RS00775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EGM183_RS00780	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EGM183_RS00785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EGM183_RS00790	COG0255	Belongs to the universal ribosomal protein uL29 family
EGM183_RS00795	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EGM183_RS00800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EGM183_RS00805	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EGM183_RS00810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EGM183_RS00815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EGM183_RS00820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EGM183_RS00825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EGM183_RS00830	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EGM183_RS00835	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EGM183_RS00840	COG1841	ribosomal large subunit assembly
EGM183_RS00845	COG0200	Binds to the 23S rRNA
EGM183_RS00850	COG0201	protein transport
EGM183_RS00855	COG0563	adenylate kinase activity
EGM183_RS00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EGM183_RS00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EGM183_RS00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EGM183_RS00875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EGM183_RS00880	COG0202	RNA polymerase activity
EGM183_RS00885	COG0203	ribosomal protein L17
EGM183_RS00895	COG1473	amidohydrolase
EGM183_RS00900	COG1122	ATPase activity
EGM183_RS00905	COG1122	ATPase activity
EGM183_RS00920	COG0393	Putative heavy-metal-binding
EGM183_RS00925	COG1114	Component of the transport system for branched-chain amino acids
EGM183_RS00940	COG1126	abc transporter atp-binding protein
EGM183_RS00945	COG0765	amino acid transport
EGM183_RS00955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EGM183_RS00960	COG0110	maltose O-acetyltransferase activity
EGM183_RS00965	COG1827	regulation of RNA biosynthetic process
EGM183_RS00970	COG1705	Flagellar rod assembly protein muramidase FlgJ
EGM183_RS00970	COG3942	CHAP domain
EGM183_RS00980	COG0039	L-malate dehydrogenase activity
EGM183_RS00985	COG0193	aminoacyl-tRNA hydrolase activity
EGM183_RS00990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EGM183_RS00995	COG2244	polysaccharide biosynthetic process
EGM183_RS01000	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EGM183_RS01010	COG1098	S1 RNA binding domain
EGM183_RS01015	COG0037	tRNA processing
EGM183_RS01020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EGM183_RS01025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGM183_RS01030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EGM183_RS01035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGM183_RS01040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EGM183_RS01185	COG3711	transcriptional antiterminator
EGM183_RS01190	COG2190	(PTS) system
EGM183_RS01190	COG1263	PTS System
EGM183_RS01190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS01195	COG2723	6-phospho-beta-galactosidase activity
EGM183_RS01200	COG2723	6-phospho-beta-galactosidase activity
EGM183_RS01210	COG0596	Alpha beta hydrolase
EGM183_RS01215	COG2169	Transcriptional regulator
EGM183_RS01220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGM183_RS01230	COG1418	mRNA catabolic process
EGM183_RS01245	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EGM183_RS01250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGM183_RS01255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGM183_RS01260	COG0167	dihydroorotate dehydrogenase activity
EGM183_RS01270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGM183_RS01280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EGM183_RS01285	COG0626	cystathionine gamma-synthase activity
EGM183_RS01290	COG2723	6-phospho-beta-galactosidase activity
EGM183_RS01295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS01305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EGM183_RS01310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EGM183_RS01325	COG2217	Heavy metal translocating P-type atpase
EGM183_RS01340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGM183_RS01345	COG3579	cysteine-type endopeptidase activity
EGM183_RS01350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGM183_RS01355	COG0346	lactoylglutathione lyase activity
EGM183_RS01360	COG2076	Multidrug Resistance protein
EGM183_RS01365	COG2076	Multidrug Resistance protein
EGM183_RS01370	COG3469	chitinase activity
EGM183_RS01375	COG3397	chitin binding
EGM183_RS01385	COG1801	Protein of unknown function DUF72
EGM183_RS01395	COG0527	aspartate kinase activity
EGM183_RS01400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGM183_RS01405	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EGM183_RS01410	COG1104	cysteine desulfurase activity
EGM183_RS01415	COG0745	RESPONSE REGULATOR receiver
EGM183_RS01420	COG5002	protein histidine kinase activity
EGM183_RS01440	COG0666	response to abiotic stimulus
EGM183_RS01455	COG3835	regulator
EGM183_RS01460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EGM183_RS01475	COG0549	Belongs to the carbamate kinase family
EGM183_RS01480	COG1301	dicarboxylic acid transport
EGM183_RS01485	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EGM183_RS01515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGM183_RS01520	COG0628	permease
EGM183_RS01540	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EGM183_RS01545	COG1757	Na H antiporter
EGM183_RS01550	COG1846	Transcriptional regulator
EGM183_RS01555	COG0778	Nitroreductase
EGM183_RS01560	COG0561	phosphatase activity
EGM183_RS01570	COG3711	transcriptional antiterminator
EGM183_RS01575	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM183_RS01585	COG2213	PTS system mannitol-specific
EGM183_RS01590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM183_RS01595	COG0246	Mannitol dehydrogenase
EGM183_RS01600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EGM183_RS01615	COG0577	efflux transmembrane transporter activity
EGM183_RS01615	COG1136	(ABC) transporter
EGM183_RS01620	COG0577	efflux transmembrane transporter activity
EGM183_RS01630	COG2814	Major facilitator Superfamily
EGM183_RS01640	COG1414	Transcriptional regulator
EGM183_RS01655	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EGM183_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
EGM183_RS01670	COG3104	oligopeptide transport
EGM183_RS01675	COG1388	LysM domain
EGM183_RS01675	COG3942	CHAP domain
EGM183_RS01685	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EGM183_RS01690	COG0318	PFAM AMP-dependent synthetase and ligase
EGM183_RS01700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EGM183_RS01705	COG2267	carboxylic ester hydrolase activity
EGM183_RS01710	COG4948	Mandelate Racemase Muconate Lactonizing
EGM183_RS01715	COG0363	glucosamine-6-phosphate deaminase activity
EGM183_RS01720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGM183_RS01725	COG1764	response to oxidative stress
EGM183_RS01740	COG3716	PTS system mannose fructose sorbose family IID component
EGM183_RS01745	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS01755	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EGM183_RS01760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EGM183_RS01775	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGM183_RS01780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EGM183_RS01785	COG1316	TRANSCRIPTIONal
EGM183_RS01790	COG0363	glucosamine-6-phosphate deaminase activity
EGM183_RS01795	COG1285	pathogenesis
EGM183_RS01810	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGM183_RS01815	COG1780	Probably involved in ribonucleotide reductase function
EGM183_RS01820	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EGM183_RS01845	COG0656	L-ascorbic acid biosynthetic process
EGM183_RS01855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGM183_RS01870	COG1113	amino acid transport
EGM183_RS01875	COG1757	Na H antiporter
EGM183_RS01890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EGM183_RS01895	COG0039	L-malate dehydrogenase activity
EGM183_RS01910	COG0583	DNA-binding transcription factor activity
EGM183_RS01925	COG1733	regulation of RNA biosynthetic process
EGM183_RS01930	COG0778	Nitroreductase
EGM183_RS01935	COG0095	Lipoate-protein ligase
EGM183_RS01955	COG1609	Transcriptional regulator
EGM183_RS01965	COG2514	catechol 2,3-dioxygenase activity
EGM183_RS01970	COG1349	DNA-binding transcription factor activity
EGM183_RS01985	COG0534	Mate efflux family protein
EGM183_RS02000	COG0217	transcriptional regulatory protein
EGM183_RS02015	COG0346	lactoylglutathione lyase activity
EGM183_RS02025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EGM183_RS02030	COG2244	polysaccharide biosynthetic process
EGM183_RS02035	COG1187	pseudouridine synthase activity
EGM183_RS02050	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
EGM183_RS02055	COG1518	maintenance of DNA repeat elements
EGM183_RS02060	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EGM183_RS02070	COG3594	Acyltransferase
EGM183_RS02075	COG1125	glycine betaine transport
EGM183_RS02075	COG0517	IMP dehydrogenase activity
EGM183_RS02080	COG1732	Glycine betaine
EGM183_RS02085	COG1438	arginine binding
EGM183_RS02090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGM183_RS02100	COG0564	pseudouridine synthase activity
EGM183_RS02105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGM183_RS02110	COG3679	Belongs to the UPF0342 family
EGM183_RS02125	COG3481	metal-dependent phosphohydrolase, HD sub domain
EGM183_RS02130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGM183_RS02140	COG0537	adenosine 5'-monophosphoramidase activity
EGM183_RS02145	COG1131	(ABC) transporter
EGM183_RS02150	COG4473	ABC transporter
EGM183_RS02155	COG0510	thiamine kinase activity
EGM183_RS02160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EGM183_RS02175	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EGM183_RS02175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM183_RS02175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EGM183_RS02185	COG3684	Belongs to the aldolase LacD family
EGM183_RS02190	COG3557	Belongs to the UPF0374 family
EGM183_RS02200	COG0628	permease
EGM183_RS02205	COG1253	flavin adenine dinucleotide binding
EGM183_RS02210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EGM183_RS02235	COG0542	response to heat
EGM183_RS02245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM183_RS02250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGM183_RS02270	COG0544	peptidyl-prolyl cis-trans isomerase activity
EGM183_RS02280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM183_RS02280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EGM183_RS02280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EGM183_RS02285	COG1105	Belongs to the carbohydrate kinase PfkB family
EGM183_RS02290	COG1349	DNA-binding transcription factor activity
EGM183_RS02300	COG0210	DNA helicase
EGM183_RS02305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGM183_RS02310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGM183_RS02315	COG0154	amidase activity
EGM183_RS02320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGM183_RS02325	COG1597	lipid kinase activity
EGM183_RS02330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGM183_RS02340	COG2197	response regulator
EGM183_RS02345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EGM183_RS02350	COG0531	amino acid
EGM183_RS02355	COG2957	Belongs to the agmatine deiminase family
EGM183_RS02360	COG0549	Belongs to the carbamate kinase family
EGM183_RS02365	COG0154	amidase activity
EGM183_RS02380	COG1428	Deoxynucleoside kinase
EGM183_RS02410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EGM183_RS02420	COG1054	Belongs to the UPF0176 family
EGM183_RS02465	COG2217	Heavy metal translocating P-type atpase
EGM183_RS02470	COG1285	pathogenesis
EGM183_RS02480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGM183_RS02485	COG0556	nucleotide-excision repair
EGM183_RS02490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EGM183_RS02500	COG1660	Displays ATPase and GTPase activities
EGM183_RS02510	COG1481	regulation of sporulation
EGM183_RS02525	COG0740	serine-type endopeptidase activity
EGM183_RS02555	COG0584	glycerophosphoryl diester phosphodiesterase
EGM183_RS02560	COG2816	NAD+ diphosphatase activity
EGM183_RS02565	COG1278	Cold shock
EGM183_RS02575	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EGM183_RS02580	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EGM183_RS02580	COG2755	lipolytic protein G-D-S-L family
EGM183_RS02585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EGM183_RS02590	COG0477	Major facilitator Superfamily
EGM183_RS02605	COG1132	(ABC) transporter
EGM183_RS02610	COG1132	(ABC) transporter
EGM183_RS02615	COG1309	transcriptional regulator
EGM183_RS02620	COG0577	efflux transmembrane transporter activity
EGM183_RS02625	COG1136	(ABC) transporter
EGM183_RS02630	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EGM183_RS02635	COG1242	4 iron, 4 sulfur cluster binding
EGM183_RS02640	COG0671	phosphoesterase, PA-phosphatase related
EGM183_RS02655	COG1388	LysM domain
EGM183_RS02655	COG1705	Flagellar rod assembly protein muramidase FlgJ
EGM183_RS02660	COG0495	leucyl-tRNA aminoacylation
EGM183_RS02680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGM183_RS02685	COG1126	abc transporter atp-binding protein
EGM183_RS02690	COG0765	amino acid transport
EGM183_RS02695	COG4166	transmembrane transport
EGM183_RS02710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EGM183_RS02715	COG1187	pseudouridine synthase activity
EGM183_RS02720	COG1011	Hydrolase
EGM183_RS02735	COG2337	Toxic component of a toxin-antitoxin (TA) module
EGM183_RS02760	COG0673	inositol 2-dehydrogenase activity
EGM183_RS02765	COG3711	transcriptional antiterminator
EGM183_RS02795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS02810	COG3964	amidohydrolase
EGM183_RS02830	COG0187	DNA topoisomerase II activity
EGM183_RS02835	COG1671	Belongs to the UPF0178 family
EGM183_RS02840	COG1181	Belongs to the D-alanine--D-alanine ligase family
EGM183_RS02845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EGM183_RS02855	COG0736	holo-[acyl-carrier-protein] synthase activity
EGM183_RS02860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EGM183_RS02865	COG2337	Toxic component of a toxin-antitoxin (TA) module
EGM183_RS02885	COG0681	Belongs to the peptidase S26 family
EGM183_RS02900	COG2365	Tyrosine phosphatase family
EGM183_RS02920	COG0531	amino acid
EGM183_RS02930	COG1174	glycine betaine transport
EGM183_RS02950	COG0346	lactoylglutathione lyase activity
EGM183_RS02955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EGM183_RS02970	COG3158	transport of potassium into the cell
EGM183_RS02980	COG2217	Heavy metal translocating P-type atpase
EGM183_RS02990	COG4989	oxidoreductase activity
EGM183_RS02995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGM183_RS02995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGM183_RS03000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EGM183_RS03005	COG0237	dephospho-CoA kinase activity
EGM183_RS03010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EGM183_RS03015	COG3611	Membrane attachment protein
EGM183_RS03020	COG1484	DNA-dependent DNA replication
EGM183_RS03040	COG1215	transferase activity, transferring glycosyl groups
EGM183_RS03065	COG1126	abc transporter atp-binding protein
EGM183_RS03070	COG0765	amino acid transport
EGM183_RS03075	COG0371	Dehydrogenase
EGM183_RS03080	COG0343	queuine tRNA-ribosyltransferase activity
EGM183_RS03085	COG1862	Preprotein translocase
EGM183_RS03095	COG1454	alcohol dehydrogenase
EGM183_RS03095	COG1012	belongs to the aldehyde dehydrogenase family
EGM183_RS03100	COG1304	FMN binding
EGM183_RS03130	COG4166	transmembrane transport
EGM183_RS03140	COG0601	transmembrane transport
EGM183_RS03145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGM183_RS03150	COG0444	Belongs to the ABC transporter superfamily
EGM183_RS03155	COG4608	Belongs to the ABC transporter superfamily
EGM183_RS03165	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EGM183_RS03170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EGM183_RS03175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EGM183_RS03185	COG3759	membrane
EGM183_RS03195	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EGM183_RS03195	COG0456	acetyltransferase
EGM183_RS03200	COG0659	secondary active sulfate transmembrane transporter activity
EGM183_RS03205	COG2855	membrane
EGM183_RS03225	COG0745	RESPONSE REGULATOR receiver
EGM183_RS03230	COG2205	protein histidine kinase activity
EGM183_RS03235	COG4975	Glucose uptake
EGM183_RS03240	COG0531	amino acid
EGM183_RS03245	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGM183_RS03245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGM183_RS03260	COG3973	AAA domain
EGM183_RS03265	COG0084	hydrolase, TatD family'
EGM183_RS03270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EGM183_RS03275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGM183_RS03285	COG3842	ATPase activity
EGM183_RS03290	COG1803	Methylglyoxal synthase
EGM183_RS03295	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EGM183_RS03300	COG1132	(ABC) transporter
EGM183_RS03305	COG1132	(ABC) transporter
EGM183_RS03315	COG3584	3D domain protein
EGM183_RS03330	COG0561	phosphatase activity
EGM183_RS03335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EGM183_RS03340	COG0280	phosphate acetyltransferase
EGM183_RS03345	COG0802	atpase or kinase
EGM183_RS03350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EGM183_RS03360	COG1609	Transcriptional regulator
EGM183_RS03365	COG2017	converts alpha-aldose to the beta-anomer
EGM183_RS03370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGM183_RS03380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS03380	COG2190	(PTS) system
EGM183_RS03380	COG1263	PTS System
EGM183_RS03390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EGM183_RS03440	COG0582	viral genome integration into host DNA
EGM183_RS03445	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EGM183_RS03450	COG0582	viral genome integration into host DNA
EGM183_RS03500	COG3064	Membrane
EGM183_RS03500	COG4991	sh3 domain protein
EGM183_RS03500	COG0515	serine threonine protein kinase
EGM183_RS03515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EGM183_RS03525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EGM183_RS03545	COG1396	sequence-specific DNA binding
EGM183_RS03560	COG3646	Phage regulatory protein
EGM183_RS03585	COG5377	YqaJ viral recombinase family
EGM183_RS03590	COG3723	Recombinational DNA repair protein, rece pathway
EGM183_RS03595	COG3935	DnaD domain protein
EGM183_RS03730	COG0228	four-way junction DNA binding
EGM183_RS03780	COG4824	toxin secretion phage lysis holin
EGM183_RS03805	COG3223	Belongs to the PsiE family
EGM183_RS03810	COG1408	metallophosphoesterase
EGM183_RS03815	COG0006	proline dipeptidase activity
EGM183_RS03820	COG1694	Mazg nucleotide pyrophosphohydrolase
EGM183_RS03825	COG1302	Protein conserved in bacteria
EGM183_RS03830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGM183_RS03835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGM183_RS03840	COG1570	exodeoxyribonuclease VII activity
EGM183_RS03845	COG1722	exodeoxyribonuclease VII activity
EGM183_RS03850	COG0142	geranyltranstransferase activity
EGM183_RS03855	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EGM183_RS03860	COG1438	arginine binding
EGM183_RS03865	COG0497	DNA recombination
EGM183_RS03885	COG2001	Belongs to the MraZ family
EGM183_RS03890	COG0275	rRNA processing
EGM183_RS03900	COG0768	penicillin binding
EGM183_RS03905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGM183_RS03910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EGM183_RS03915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGM183_RS03920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EGM183_RS03925	COG0849	cell division
EGM183_RS03930	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EGM183_RS03935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EGM183_RS03940	COG1799	cell septum assembly
EGM183_RS03945	COG0762	integral membrane protein
EGM183_RS03950	COG2302	S4 RNA-binding domain
EGM183_RS03955	COG3599	regulation of cell shape
EGM183_RS03960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EGM183_RS03965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EGM183_RS03985	COG0673	inositol 2-dehydrogenase activity
EGM183_RS03995	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EGM183_RS03995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EGM183_RS04000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS04005	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS04025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS04030	COG1447	Phosphotransferase system cellobiose-specific component IIA
EGM183_RS04035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS04040	COG2723	6-phospho-beta-galactosidase activity
EGM183_RS04060	COG0574	Belongs to the PEP-utilizing enzyme family
EGM183_RS04060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGM183_RS04065	COG0517	IMP dehydrogenase activity
EGM183_RS04070	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EGM183_RS04075	COG0392	lysyltransferase activity
EGM183_RS04075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EGM183_RS04120	COG0105	UTP biosynthetic process
EGM183_RS04135	COG0561	phosphatase activity
EGM183_RS04145	COG2252	PERMEase
EGM183_RS04150	COG2814	Major facilitator Superfamily
EGM183_RS04160	COG0587	DNA-directed DNA polymerase activity
EGM183_RS04165	COG0205	6-phosphofructokinase activity
EGM183_RS04180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EGM183_RS04185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EGM183_RS04190	COG0745	RESPONSE REGULATOR receiver
EGM183_RS04195	COG5002	protein histidine kinase activity
EGM183_RS04285	COG1116	anion transmembrane transporter activity
EGM183_RS04290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EGM183_RS04295	COG1660	Displays ATPase and GTPase activities
EGM183_RS04300	COG1914	H( )-stimulated, divalent metal cation uptake system
EGM183_RS04310	COG2508	Transcriptional regulator
EGM183_RS04315	COG4166	transmembrane transport
EGM183_RS04320	COG0402	S-adenosylhomocysteine deaminase activity
EGM183_RS04325	COG0402	S-adenosylhomocysteine deaminase activity
EGM183_RS04330	COG1956	GAF domain-containing protein
EGM183_RS04340	COG0110	maltose O-acetyltransferase activity
EGM183_RS04355	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EGM183_RS04360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EGM183_RS04365	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EGM183_RS04370	COG1609	Transcriptional regulator
EGM183_RS04400	COG2814	Major facilitator Superfamily
EGM183_RS04405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EGM183_RS04435	COG0456	acetyltransferase
EGM183_RS04525	COG1113	amino acid transport
EGM183_RS04540	COG0247	lactate metabolic process
EGM183_RS04545	COG1139	Iron-sulfur cluster binding protein
EGM183_RS04560	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EGM183_RS04565	COG1074	ATP-dependent DNA helicase activity
EGM183_RS04570	COG1733	regulation of RNA biosynthetic process
EGM183_RS04575	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EGM183_RS04580	COG0072	phenylalanine-tRNA ligase activity
EGM183_RS04580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGM183_RS04585	COG0765	amino acid transport
EGM183_RS04590	COG0765	amino acid transport
EGM183_RS04595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGM183_RS04605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EGM183_RS04610	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EGM183_RS04615	COG0622	Phosphoesterase
EGM183_RS04620	COG1349	DNA-binding transcription factor activity
EGM183_RS04630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM183_RS04635	COG3037	sugar-specific permease SgaT UlaA
EGM183_RS04645	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EGM183_RS04650	COG3623	hexulose-6-phosphate isomerase
EGM183_RS04660	COG0517	IMP dehydrogenase activity
EGM183_RS04665	COG2171	N-acyltransferase activity
EGM183_RS04670	COG1473	amidohydrolase
EGM183_RS04675	COG0668	transmembrane transport
EGM183_RS04685	COG0656	L-ascorbic acid biosynthetic process
EGM183_RS04690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EGM183_RS04710	COG1078	dGTPase activity
EGM183_RS04715	COG0095	Lipoate-protein ligase
EGM183_RS04730	COG0504	CTP synthase activity
EGM183_RS04735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EGM183_RS04740	COG3331	DNA recombination
EGM183_RS04745	COG4474	Belongs to the UPF0398 family
EGM183_RS04750	COG3599	regulation of cell shape
EGM183_RS04760	COG0116	Belongs to the methyltransferase superfamily
EGM183_RS04765	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EGM183_RS04770	COG3935	DnaD domain protein
EGM183_RS04775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGM183_RS04780	COG2188	Transcriptional regulator
EGM183_RS04790	COG1446	asparaginase
EGM183_RS04795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS04800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS04825	COG1666	GTP binding
EGM183_RS04830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EGM183_RS04835	COG0191	fructose-bisphosphate aldolase activity
EGM183_RS04840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EGM183_RS04845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EGM183_RS04850	COG0254	rRNA binding
EGM183_RS04865	COG1940	carbohydrate kinase activity
EGM183_RS04870	COG3237	CsbD-like
EGM183_RS04875	COG0778	Nitroreductase
EGM183_RS04880	COG1854	S-ribosylhomocysteine lyase activity
EGM183_RS04885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EGM183_RS04890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGM183_RS04900	COG0737	Belongs to the 5'-nucleotidase family
EGM183_RS04905	COG4470	Protein conserved in bacteria
EGM183_RS04910	COG0647	UMP catabolic process
EGM183_RS04925	COG1307	EDD domain protein, DegV family
EGM183_RS04930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EGM183_RS04935	COG0745	RESPONSE REGULATOR receiver
EGM183_RS04940	COG5002	protein histidine kinase activity
EGM183_RS04955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EGM183_RS04960	COG0701	Predicted permease
EGM183_RS04965	COG3689	TIGRFAM TIGR03943 family protein
EGM183_RS04980	COG4472	Bacterial protein of unknown function (DUF965)
EGM183_RS04985	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EGM183_RS04990	COG3906	Belongs to the UPF0473 family
EGM183_RS05005	COG3493	citrate carrier protein
EGM183_RS05010	COG3290	protein histidine kinase activity
EGM183_RS05015	COG4565	transcriptional regulatory protein
EGM183_RS05020	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGM183_RS05050	COG1131	(ABC) transporter
EGM183_RS05060	COG1316	TRANSCRIPTIONal
EGM183_RS05065	COG0028	Belongs to the TPP enzyme family
EGM183_RS05070	COG3527	Alpha-acetolactate decarboxylase
EGM183_RS05090	COG1175	transmembrane transport
EGM183_RS05100	COG3842	ATPase activity
EGM183_RS05110	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EGM183_RS05115	COG0402	S-adenosylhomocysteine deaminase activity
EGM183_RS05135	COG0431	NADPH-dependent FMN reductase
EGM183_RS05135	COG3976	FMN-binding domain protein
EGM183_RS05135	COG1053	succinate dehydrogenase
EGM183_RS05150	COG1408	metallophosphoesterase
EGM183_RS05155	COG4209	transmembrane transport
EGM183_RS05160	COG0395	ABC-type sugar transport system, permease component
EGM183_RS05175	COG3458	cephalosporin-C deacetylase activity
EGM183_RS05185	COG1472	Belongs to the glycosyl hydrolase 3 family
EGM183_RS05190	COG3459	Glycosyltransferase 36 associated
EGM183_RS05195	COG1609	Transcriptional regulator
EGM183_RS05205	COG2188	Transcriptional regulator
EGM183_RS05210	COG2723	6-phospho-beta-galactosidase activity
EGM183_RS05215	COG0673	inositol 2-dehydrogenase activity
EGM183_RS05220	COG2707	UPF0756 membrane protein
EGM183_RS05235	COG1293	RNA-binding protein homologous to eukaryotic snRNP
EGM183_RS05255	COG1122	ATPase activity
EGM183_RS05275	COG0561	phosphatase activity
EGM183_RS05280	COG0745	RESPONSE REGULATOR receiver
EGM183_RS05285	COG3850	Histidine kinase
EGM183_RS05285	COG5002	protein histidine kinase activity
EGM183_RS05300	COG1368	sulfuric ester hydrolase activity
EGM183_RS05305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EGM183_RS05310	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGM183_RS05315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EGM183_RS05320	COG4932	domain protein
EGM183_RS05320	COG1388	LysM domain
EGM183_RS05325	COG0779	Required for maturation of 30S ribosomal subunits
EGM183_RS05330	COG0195	Participates in both transcription termination and antitermination
EGM183_RS05335	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EGM183_RS05345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EGM183_RS05350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EGM183_RS05425	COG4824	toxin secretion phage lysis holin
EGM183_RS05435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EGM183_RS05440	COG0196	riboflavin kinase activity
EGM183_RS05450	COG1695	Transcriptional regulator
EGM183_RS05470	COG0772	Belongs to the SEDS family
EGM183_RS05475	COG0583	DNA-binding transcription factor activity
EGM183_RS05480	COG0583	DNA-binding transcription factor activity
EGM183_RS05485	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EGM183_RS05490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGM183_RS05495	COG1420	regulation of RNA biosynthetic process
EGM183_RS05500	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EGM183_RS05505	COG0443	Heat shock 70 kDa protein
EGM183_RS05510	COG0484	heat shock protein binding
EGM183_RS05515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EGM183_RS05520	COG2183	response to ionizing radiation
EGM183_RS05525	COG3091	SprT-like family
EGM183_RS05535	COG0436	Aminotransferase
EGM183_RS05580	COG2268	Band 7 protein
EGM183_RS05605	COG1309	transcriptional regulator
EGM183_RS05615	COG2188	Transcriptional regulator
EGM183_RS05620	COG4842	Belongs to the WXG100 family
EGM183_RS05640	COG4499	WXG100 protein secretion system (Wss), protein YukC
EGM183_RS05645	COG1674	ftsk spoiiie
EGM183_RS05715	COG0492	ferredoxin-NADP+ reductase activity
EGM183_RS05730	COG1136	(ABC) transporter
EGM183_RS05730	COG0577	efflux transmembrane transporter activity
EGM183_RS05730	COG1136	(ABC) transporter
EGM183_RS05730	COG0577	efflux transmembrane transporter activity
EGM183_RS05740	COG3833	ABC-type maltose transport systems, permease component
EGM183_RS05745	COG1175	transmembrane transport
EGM183_RS05750	COG2182	Extracellular solute-binding protein
EGM183_RS05755	COG0366	Alpha amylase catalytic
EGM183_RS05760	COG0366	Alpha amylase catalytic
EGM183_RS05765	COG0366	Alpha amylase catalytic
EGM183_RS05775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EGM183_RS05805	COG0371	Dehydrogenase
EGM183_RS05810	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EGM183_RS05815	COG2376	Dihydroxyacetone kinase
EGM183_RS05820	COG1461	Dihydroxyacetone kinase
EGM183_RS05830	COG3425	synthase
EGM183_RS05840	COG0628	permease
EGM183_RS05850	COG1278	Cold shock
EGM183_RS05865	COG2814	Major facilitator Superfamily
EGM183_RS05870	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EGM183_RS05875	COG4109	DRTGG domain
EGM183_RS05880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EGM183_RS05885	COG2824	Alkylphosphonate utilization operon protein PhnA
EGM183_RS05900	COG0513	Belongs to the DEAD box helicase family
EGM183_RS05910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGM183_RS05915	COG2384	SAM-dependent methyltransferase
EGM183_RS05920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EGM183_RS05925	COG2195	Cleaves the N-terminal amino acid of tripeptides
EGM183_RS05940	COG0746	molybdenum cofactor guanylyltransferase activity
EGM183_RS05945	COG2116	formate transmembrane transporter activity
EGM183_RS05960	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EGM183_RS05965	COG3383	formate dehydrogenase (NAD+) activity
EGM183_RS05970	COG0303	'Molybdopterin
EGM183_RS05975	COG0315	cyclic pyranopterin monophosphate synthase activity
EGM183_RS05990	COG0521	Mo-molybdopterin cofactor biosynthetic process
EGM183_RS06000	COG0725	ABC transporter, periplasmic molybdate-binding protein
EGM183_RS06005	COG4149	molybdate abc transporter
EGM183_RS06010	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EGM183_RS06015	COG2217	Heavy metal translocating P-type atpase
EGM183_RS06025	COG1286	toxin biosynthetic process
EGM183_RS06030	COG1193	negative regulation of DNA recombination
EGM183_RS06035	COG3118	belongs to the thioredoxin family
EGM183_RS06040	COG0322	excinuclease ABC activity
EGM183_RS06050	COG4152	abc transporter atp-binding protein
EGM183_RS06055	COG1668	transmembrane transport
EGM183_RS06060	COG1609	Transcriptional regulator
EGM183_RS06065	COG1486	melibiose metabolic process
EGM183_RS06080	COG2081	HI0933 family
EGM183_RS06090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGM183_RS06095	COG0166	Belongs to the GPI family
EGM183_RS06115	COG1269	ATP hydrolysis coupled proton transport
EGM183_RS06120	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGM183_RS06125	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
EGM183_RS06130	COG1527	subunit (C
EGM183_RS06135	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
EGM183_RS06140	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
EGM183_RS06145	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
EGM183_RS06150	COG1394	ATPase activity, coupled to movement of substances
EGM183_RS06165	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
EGM183_RS06170	COG0019	diaminopimelate decarboxylase activity
EGM183_RS06195	COG2151	metal-sulfur cluster biosynthetic enzyme
EGM183_RS06200	COG4948	Mandelate Racemase Muconate Lactonizing
EGM183_RS06210	COG4166	transmembrane transport
EGM183_RS06215	COG3711	transcriptional antiterminator
EGM183_RS06225	COG0741	lytic transglycosylase activity
EGM183_RS06230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EGM183_RS06235	COG0358	DNA primase activity
EGM183_RS06240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGM183_RS06250	COG2996	Protein conserved in bacteria
EGM183_RS06255	COG0735	belongs to the Fur family
EGM183_RS06265	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EGM183_RS06275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS06290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EGM183_RS06305	COG4974	Belongs to the 'phage' integrase family
EGM183_RS06310	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EGM183_RS06315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EGM183_RS06320	COG1187	pseudouridine synthase activity
EGM183_RS06325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EGM183_RS06345	COG0514	ATP-dependent DNA helicase (RecQ)
EGM183_RS06355	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EGM183_RS06360	COG0539	negative regulation of cytoplasmic translation
EGM183_RS06365	COG1160	GTP binding
EGM183_RS06380	COG0457	Tetratricopeptide repeat
EGM183_RS06385	COG5582	Belongs to the UPF0302 family
EGM183_RS06390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EGM183_RS06395	COG1694	Mazg nucleotide pyrophosphohydrolase
EGM183_RS06400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EGM183_RS06405	COG0617	tRNA 3'-terminal CCA addition
EGM183_RS06420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EGM183_RS06425	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EGM183_RS06435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EGM183_RS06440	COG0287	Prephenate dehydrogenase
EGM183_RS06450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EGM183_RS06455	COG0077	Prephenate dehydratase
EGM183_RS06465	COG1307	EDD domain protein, DegV family
EGM183_RS06490	COG0488	(ABC) transporter
EGM183_RS06495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EGM183_RS06505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EGM183_RS06510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EGM183_RS06515	COG4224	UPF0291 protein
EGM183_RS06525	COG2814	Major facilitator Superfamily
EGM183_RS06530	COG1705	Flagellar rod assembly protein muramidase FlgJ
EGM183_RS06530	COG1388	LysM domain
EGM183_RS06540	COG0735	belongs to the Fur family
EGM183_RS06545	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGM183_RS06550	COG2816	NAD+ diphosphatase activity
EGM183_RS06565	COG2207	Transcriptional regulator
EGM183_RS06570	COG1132	(ABC) transporter
EGM183_RS06575	COG1132	(ABC) transporter
EGM183_RS06590	COG0753	catalase activity
EGM183_RS06595	COG0415	Belongs to the DNA photolyase family
EGM183_RS06605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS06605	COG1263	PTS System
EGM183_RS06605	COG2190	(PTS) system
EGM183_RS06610	COG0366	Alpha amylase catalytic
EGM183_RS06620	COG1609	Transcriptional regulator
EGM183_RS06630	COG2723	6-phospho-beta-galactosidase activity
EGM183_RS06635	COG1263	PTS System
EGM183_RS06635	COG2190	(PTS) system
EGM183_RS06635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS06645	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EGM183_RS06655	COG1227	inorganic diphosphatase activity
EGM183_RS06660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EGM183_RS06665	COG1882	Formate acetyltransferase
EGM183_RS06670	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EGM183_RS06675	COG0187	DNA topoisomerase II activity
EGM183_RS06680	COG1832	CoA-binding protein
EGM183_RS06685	COG4766	ethanolamine catabolic process
EGM183_RS06690	COG3192	ethanolamine utilization protein
EGM183_RS06695	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
EGM183_RS06705	COG4869	propanediol catabolic process
EGM183_RS06720	COG1012	belongs to the aldehyde dehydrogenase family
EGM183_RS06720	COG1454	alcohol dehydrogenase
EGM183_RS06735	COG4302	ethanolamine ammonia-lyase activity
EGM183_RS06740	COG4303	Ethanolamine ammonia lyase large subunit
EGM183_RS06770	COG2096	Adenosyltransferase
EGM183_RS06780	COG1120	ATPase activity
EGM183_RS06785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGM183_RS06790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EGM183_RS06795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EGM183_RS06805	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EGM183_RS06810	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EGM183_RS06815	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EGM183_RS06825	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EGM183_RS06830	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EGM183_RS06835	COG1266	CAAX protease self-immunity
EGM183_RS06840	COG0758	DNA mediated transformation
EGM183_RS06845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGM183_RS06855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EGM183_RS06860	COG0583	DNA-binding transcription factor activity
EGM183_RS06870	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGM183_RS06875	COG0022	dehydrogenase e1 component
EGM183_RS06880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EGM183_RS06885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGM183_RS06890	COG3426	butyrate kinase activity
EGM183_RS06895	COG0280	phosphate acetyltransferase
EGM183_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
EGM183_RS06925	COG0346	lactoylglutathione lyase activity
EGM183_RS06935	COG0604	alcohol dehydrogenase
EGM183_RS06945	COG1131	(ABC) transporter
EGM183_RS06960	COG0681	Belongs to the peptidase S26 family
EGM183_RS06965	COG3409	Peptidoglycan-binding domain 1 protein
EGM183_RS06965	COG0793	Belongs to the peptidase S41A family
EGM183_RS06970	COG4479	Belongs to the UPF0346 family
EGM183_RS06975	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGM183_RS06980	COG4698	Protein conserved in bacteria
EGM183_RS06985	COG2755	lipolytic protein G-D-S-L family
EGM183_RS06990	COG1307	EDD domain protein, DegV family
EGM183_RS06995	COG1272	protein, Hemolysin III
EGM183_RS07005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGM183_RS07010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EGM183_RS07010	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EGM183_RS07015	COG5416	Lipopolysaccharide assembly protein A domain
EGM183_RS07020	COG0300	oxidoreductase activity
EGM183_RS07025	COG1234	tRNA 3'-trailer cleavage
EGM183_RS07035	COG1837	Belongs to the UPF0109 family
EGM183_RS07040	COG0228	four-way junction DNA binding
EGM183_RS07045	COG1214	PFAM Peptidase M22, glycoprotease
EGM183_RS07045	COG0456	acetyltransferase
EGM183_RS07050	COG0431	NADPH-dependent FMN reductase
EGM183_RS07055	COG0789	Transcriptional regulator
EGM183_RS07060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EGM183_RS07065	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EGM183_RS07070	COG1683	Conserved Protein
EGM183_RS07075	COG0745	RESPONSE REGULATOR receiver
EGM183_RS07080	COG5002	protein histidine kinase activity
EGM183_RS07090	COG0436	Aminotransferase
EGM183_RS07095	COG0383	alpha-mannosidase activity
EGM183_RS07105	COG1609	Transcriptional regulator
EGM183_RS07110	COG0583	DNA-binding transcription factor activity
EGM183_RS07125	COG0284	orotidine-5'-phosphate decarboxylase activity
EGM183_RS07130	COG0167	dihydroorotate dehydrogenase activity
EGM183_RS07135	COG0543	2 iron, 2 sulfur cluster binding
EGM183_RS07140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EGM183_RS07145	COG0505	Belongs to the CarA family
EGM183_RS07150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EGM183_RS07155	COG0540	Belongs to the ATCase OTCase family
EGM183_RS07160	COG2233	PERMEase
EGM183_RS07170	COG0564	pseudouridine synthase activity
EGM183_RS07175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EGM183_RS07185	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EGM183_RS07190	COG1278	Cold shock
EGM183_RS07200	COG0328	RNA-DNA hybrid ribonuclease activity
EGM183_RS07205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EGM183_RS07210	COG0710	3-dehydroquinate dehydratase activity
EGM183_RS07215	COG1132	(ABC) transporter
EGM183_RS07220	COG1132	(ABC) transporter
EGM183_RS07225	COG3763	UPF0154 protein
EGM183_RS07230	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EGM183_RS07255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EGM183_RS07265	COG1609	Transcriptional regulator
EGM183_RS07270	COG0006	proline dipeptidase activity
EGM183_RS07275	COG4980	gas vesicle protein
EGM183_RS07285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGM183_RS07290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EGM183_RS07295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EGM183_RS07300	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EGM183_RS07305	COG0322	excinuclease ABC activity
EGM183_RS07310	COG1950	PFAM Membrane protein of
EGM183_RS07320	COG3595	metallopeptidase activity
EGM183_RS07325	COG0704	Plays a role in the regulation of phosphate uptake
EGM183_RS07330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EGM183_RS07335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EGM183_RS07340	COG0581	inorganic phosphate transmembrane transporter activity
EGM183_RS07345	COG0573	inorganic phosphate transmembrane transporter activity
EGM183_RS07355	COG2177	Part of the ABC transporter FtsEX involved in
EGM183_RS07360	COG2884	Cell division ATP-binding protein ftsE
EGM183_RS07370	COG0653	protein targeting
EGM183_RS07385	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EGM183_RS07390	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS07400	COG1739	Uncharacterized protein family UPF0029
EGM183_RS07410	COG1028	Short-chain dehydrogenase reductase Sdr
EGM183_RS07430	COG0151	Belongs to the GarS family
EGM183_RS07435	COG0138	bifunctional purine biosynthesis protein purh
EGM183_RS07440	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EGM183_RS07445	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EGM183_RS07455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGM183_RS07460	COG0047	phosphoribosylformylglycinamidine synthase activity
EGM183_RS07465	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGM183_RS07470	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EGM183_RS07475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EGM183_RS07480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EGM183_RS07490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EGM183_RS07495	COG4166	transmembrane transport
EGM183_RS07505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EGM183_RS07510	COG4876	unkown
EGM183_RS07525	COG0628	permease
EGM183_RS07530	COG1470	cell adhesion involved in biofilm formation
EGM183_RS07530	COG0366	Alpha amylase catalytic
EGM183_RS07540	COG3716	PTS system mannose fructose sorbose family IID component
EGM183_RS07545	COG3715	PTS system
EGM183_RS07550	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM183_RS07550	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS07560	COG1105	Belongs to the carbohydrate kinase PfkB family
EGM183_RS07565	COG3684	Belongs to the aldolase LacD family
EGM183_RS07570	COG2222	sugar isomerase
EGM183_RS07575	COG2188	Transcriptional regulator
EGM183_RS07580	COG1442	glycosyl transferase family 8
EGM183_RS07585	COG1442	glycosyl transferase family 8
EGM183_RS07590	COG1368	sulfuric ester hydrolase activity
EGM183_RS07600	COG0583	DNA-binding transcription factor activity
EGM183_RS07615	COG3227	Zinc metalloprotease (Elastase)
EGM183_RS07635	COG3942	CHAP domain
EGM183_RS07635	COG1705	Flagellar rod assembly protein muramidase FlgJ
EGM183_RS07650	COG1064	alcohol dehydrogenase
EGM183_RS07685	COG1606	tRNA processing
EGM183_RS07690	COG1122	ATPase activity
EGM183_RS07700	COG0310	cobalt ion transport
EGM183_RS07705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGM183_RS07710	COG3875	lactate racemase activity
EGM183_RS07715	COG1691	(AIR) carboxylase
EGM183_RS07720	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
EGM183_RS07725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EGM183_RS07740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS07740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM183_RS07745	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM183_RS07780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EGM183_RS07810	COG0335	large ribosomal subunit rRNA binding
EGM183_RS07815	COG0336	Belongs to the RNA methyltransferase TrmD family
EGM183_RS07820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EGM183_RS07825	COG1914	H( )-stimulated, divalent metal cation uptake system
EGM183_RS07835	COG0398	Pfam SNARE associated Golgi protein
EGM183_RS07840	COG0584	glycerophosphoryl diester phosphodiesterase
EGM183_RS07855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGM183_RS07870	COG4129	membrane
EGM183_RS07880	COG1940	carbohydrate kinase activity
EGM183_RS07885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGM183_RS07895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EGM183_RS07900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EGM183_RS07905	COG2706	6-phosphogluconolactonase activity
EGM183_RS07915	COG3069	C4-dicarboxylate transmembrane transporter activity
EGM183_RS07945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EGM183_RS07955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGM183_RS07995	COG2364	Membrane
EGM183_RS08000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGM183_RS08010	COG2814	Major facilitator Superfamily
EGM183_RS08015	COG1368	sulfuric ester hydrolase activity
EGM183_RS08045	COG3716	PTS system mannose fructose sorbose family IID component
EGM183_RS08050	COG3715	PTS system
EGM183_RS08080	COG0149	triose-phosphate isomerase activity
EGM183_RS08085	COG0126	phosphoglycerate kinase activity
EGM183_RS08095	COG2390	Transcriptional regulator
EGM183_RS08100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EGM183_RS08105	COG4475	Protein of unknown function (DUF436)
EGM183_RS08110	COG4720	Psort location CytoplasmicMembrane, score
EGM183_RS08115	COG0351	phosphomethylpyrimidine kinase
EGM183_RS08120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EGM183_RS08125	COG0124	histidyl-tRNA synthetase
EGM183_RS08130	COG1490	D-aminoacyl-tRNA deacylase activity
EGM183_RS08135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EGM183_RS08140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EGM183_RS08145	COG2264	protein methyltransferase activity
EGM183_RS08155	COG2094	Belongs to the DNA glycosylase MPG family
EGM183_RS08160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EGM183_RS08175	COG0589	response to stress
EGM183_RS08180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EGM183_RS08185	COG0827	DNA restriction-modification system
EGM183_RS08210	COG4537	Required for transformation and DNA binding
EGM183_RS08220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM183_RS08225	COG0531	amino acid
EGM183_RS08230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EGM183_RS08235	COG0577	efflux transmembrane transporter activity
EGM183_RS08240	COG1136	(ABC) transporter
EGM183_RS08250	COG1674	ftsk spoiiie
EGM183_RS08255	COG1252	NADH dehydrogenase
EGM183_RS08270	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EGM183_RS08275	COG4988	ABC transporter
EGM183_RS08280	COG1294	oxidase, subunit
EGM183_RS08285	COG1271	oxidase subunit
EGM183_RS08290	COG3708	Transcriptional regulator
EGM183_RS08290	COG2207	Transcriptional regulator
EGM183_RS08310	COG1881	PFAM PEBP family protein
EGM183_RS08320	COG0482	sulfurtransferase activity
EGM183_RS08330	COG1104	cysteine desulfurase activity
EGM183_RS08335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EGM183_RS08340	COG1121	(ABC) transporter
EGM183_RS08345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGM183_RS08355	COG0488	(ABC) transporter
EGM183_RS08360	COG1473	amidohydrolase
EGM183_RS08370	COG2011	ABC-type metal ion transport system permease component
EGM183_RS08375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGM183_RS08410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EGM183_RS08420	COG1122	ATPase activity
EGM183_RS08425	COG4720	Psort location CytoplasmicMembrane, score
EGM183_RS08430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGM183_RS08440	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EGM183_RS08455	COG0789	Transcriptional regulator
EGM183_RS08460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EGM183_RS08465	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EGM183_RS08470	COG0584	glycerophosphoryl diester phosphodiesterase
EGM183_RS08500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGM183_RS08505	COG3475	LICD family
EGM183_RS08510	COG0438	transferase activity, transferring glycosyl groups
EGM183_RS08520	COG1216	Glycosyl transferase, family 2
EGM183_RS08520	COG1442	glycosyl transferase family 8
EGM183_RS08525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGM183_RS08535	COG3475	LICD family
EGM183_RS08545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EGM183_RS08560	COG1216	Glycosyl transferase, family 2
EGM183_RS08560	COG0438	transferase activity, transferring glycosyl groups
EGM183_RS08565	COG0438	transferase activity, transferring glycosyl groups
EGM183_RS08565	COG1216	Glycosyl transferase, family 2
EGM183_RS08570	COG1134	teichoic acid transport
EGM183_RS08575	COG1682	transport, permease protein
EGM183_RS08590	COG1215	transferase activity, transferring glycosyl groups
EGM183_RS08595	COG1091	dTDP-4-dehydrorhamnose reductase activity
EGM183_RS08600	COG1088	dTDP-glucose 4,6-dehydratase activity
EGM183_RS08610	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EGM183_RS08630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGM183_RS08635	COG1295	ribonuclease BN
EGM183_RS08640	COG0024	Methionine aminopeptidase
EGM183_RS08645	COG0716	FMN binding
EGM183_RS08650	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EGM183_RS08655	COG1309	transcriptional regulator
EGM183_RS08660	COG2309	aminopeptidase activity
EGM183_RS08670	COG0590	tRNA wobble adenosine to inosine editing
EGM183_RS08680	COG0384	phenazine biosynthesis protein PhzF
EGM183_RS08690	COG2738	Putative neutral zinc metallopeptidase
EGM183_RS08705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS08705	COG1263	PTS System
EGM183_RS08710	COG0346	lactoylglutathione lyase activity
EGM183_RS08730	COG4753	response regulator
EGM183_RS08730	COG2207	Transcriptional regulator
EGM183_RS08735	COG2972	Histidine kinase
EGM183_RS08745	COG1653	transport
EGM183_RS08750	COG0395	ABC-type sugar transport system, permease component
EGM183_RS08755	COG1175	transmembrane transport
EGM183_RS08780	COG1132	(ABC) transporter
EGM183_RS08805	COG0395	ABC-type sugar transport system, permease component
EGM183_RS08810	COG1175	transmembrane transport
EGM183_RS08820	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EGM183_RS08835	COG1609	Transcriptional regulator
EGM183_RS08850	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGM183_RS08855	COG1082	Xylose isomerase domain protein TIM barrel
EGM183_RS08860	COG0673	inositol 2-dehydrogenase activity
EGM183_RS08870	COG1012	belongs to the aldehyde dehydrogenase family
EGM183_RS08875	COG3718	enzyme involved in inositol metabolism
EGM183_RS08880	COG3962	Belongs to the TPP enzyme family
EGM183_RS08885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGM183_RS08890	COG1609	Transcriptional regulator
EGM183_RS08895	COG0481	GTPase activity
EGM183_RS08915	COG0542	response to heat
EGM183_RS08935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EGM183_RS08940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EGM183_RS08950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGM183_RS08960	COG1705	Flagellar rod assembly protein muramidase FlgJ
EGM183_RS08980	COG0017	Asparaginyl-tRNA synthetase
EGM183_RS08985	COG0436	Aminotransferase
EGM183_RS08995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EGM183_RS08995	COG1199	ATP-dependent helicase activity
EGM183_RS09005	COG0531	amino acid
EGM183_RS09015	COG0442	prolyl-tRNA aminoacylation
EGM183_RS09020	COG0750	zinc metalloprotease
EGM183_RS09025	COG1028	Short-chain dehydrogenase reductase Sdr
EGM183_RS09035	COG0719	Fe-S assembly protein
EGM183_RS09045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EGM183_RS09050	COG0719	Fe-S assembly protein
EGM183_RS09060	COG0233	cytoplasmic translational termination
EGM183_RS09065	COG0528	UMP kinase activity
EGM183_RS09070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EGM183_RS09075	COG0052	Belongs to the universal ribosomal protein uS2 family
EGM183_RS09085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGM183_RS09090	COG1254	Belongs to the acylphosphatase family
EGM183_RS09095	COG0706	membrane insertase activity
EGM183_RS09105	COG0751	glycine-tRNA ligase activity
EGM183_RS09110	COG0752	glycyl-tRNA synthetase alpha subunit
EGM183_RS09115	COG1381	Involved in DNA repair and RecF pathway recombination
EGM183_RS09120	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGM183_RS09125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EGM183_RS09130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EGM183_RS09140	COG1702	phosphate starvation-inducible protein PhoH
EGM183_RS09145	COG1610	YqeY-like protein
EGM183_RS09150	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EGM183_RS09155	COG0735	belongs to the Fur family
EGM183_RS09160	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EGM183_RS09165	COG0083	homoserine kinase activity
EGM183_RS09175	COG0460	homoserine dehydrogenase
EGM183_RS09180	COG0640	Transcriptional regulator
EGM183_RS09185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EGM183_RS09190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGM183_RS09195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EGM183_RS09210	COG0516	GMP reductase activity
EGM183_RS09220	COG0402	S-adenosylhomocysteine deaminase activity
EGM183_RS09235	COG1737	Transcriptional regulator
EGM183_RS09240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS09240	COG1263	PTS System
EGM183_RS09245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EGM183_RS09255	COG2190	(PTS) system
EGM183_RS09255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS09255	COG1263	PTS System
EGM183_RS09260	COG1968	undecaprenyl-diphosphatase activity
EGM183_RS09265	COG3394	polysaccharide catabolic process
EGM183_RS09275	COG0306	phosphate transporter
EGM183_RS09280	COG0268	Binds directly to 16S ribosomal RNA
EGM183_RS09285	COG1607	acyl-coa hydrolase
EGM183_RS09290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EGM183_RS09295	COG1466	dna polymerase III delta subunit
EGM183_RS09300	COG2333	competence protein COMEC
EGM183_RS09300	COG0658	competence protein
EGM183_RS09305	COG2131	deaminase
EGM183_RS09310	COG1555	photosystem II stabilization
EGM183_RS09315	COG3480	Lon protease (S16) C-terminal proteolytic domain
EGM183_RS09320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EGM183_RS09325	COG0742	ribosomal rna small subunit methyltransferase
EGM183_RS09330	COG4471	UPF0298 protein
EGM183_RS09345	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EGM183_RS09350	COG0772	Belongs to the SEDS family
EGM183_RS09355	COG4838	Belongs to the UPF0358 family
EGM183_RS09360	COG0514	ATP-dependent DNA helicase (RecQ)
EGM183_RS09365	COG1217	gtp-binding protein TYPA
EGM183_RS09370	COG0483	inositol monophosphate 1-phosphatase activity
EGM183_RS09375	COG4476	Belongs to the UPF0223 family
EGM183_RS09380	COG0038	chloride channel
EGM183_RS09400	COG0018	arginyl-trna synthetase
EGM183_RS09405	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EGM183_RS09410	COG0456	acetyltransferase
EGM183_RS09420	COG1214	PFAM Peptidase M22, glycoprotease
EGM183_RS09470	COG4589	Belongs to the CDS family
EGM183_RS09475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EGM183_RS09480	COG1464	Belongs to the NlpA lipoprotein family
EGM183_RS09485	COG2011	ABC-type metal ion transport system permease component
EGM183_RS09490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EGM183_RS09495	COG0509	glycine decarboxylation via glycine cleavage system
EGM183_RS09500	COG1393	Belongs to the ArsC family
EGM183_RS09505	COG0772	Belongs to the SEDS family
EGM183_RS09530	COG1396	sequence-specific DNA binding
EGM183_RS09560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EGM183_RS09565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGM183_RS09570	COG0009	L-threonylcarbamoyladenylate synthase
EGM183_RS09575	COG2890	protein-(glutamine-N5) methyltransferase activity
EGM183_RS09580	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EGM183_RS09585	COG1435	thymidine kinase activity
EGM183_RS09590	COG1053	succinate dehydrogenase
EGM183_RS09595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EGM183_RS09605	COG0493	'glutamate synthase
EGM183_RS09605	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGM183_RS09610	COG0543	2 iron, 2 sulfur cluster binding
EGM183_RS09615	COG0716	FMN binding
EGM183_RS09620	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EGM183_RS09620	COG3608	succinylglutamate desuccinylase aspartoacylase
EGM183_RS09625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EGM183_RS09645	COG1104	cysteine desulfurase activity
EGM183_RS09650	COG0746	molybdenum cofactor guanylyltransferase activity
EGM183_RS09660	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EGM183_RS09660	COG3608	succinylglutamate desuccinylase aspartoacylase
EGM183_RS09675	COG0251	oxidation-reduction process
EGM183_RS09680	COG0549	Belongs to the carbamate kinase family
EGM183_RS09685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EGM183_RS09690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGM183_RS09705	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGM183_RS09705	COG0493	'glutamate synthase
EGM183_RS09710	COG0402	S-adenosylhomocysteine deaminase activity
EGM183_RS09720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EGM183_RS09725	COG3442	glutamine amidotransferase
EGM183_RS09730	COG1957	nucleoside hydrolase
EGM183_RS09740	COG1482	cell wall glycoprotein biosynthetic process
EGM183_RS09755	COG1132	(ABC) transporter
EGM183_RS09770	COG0194	GDP metabolic process
EGM183_RS09775	COG2723	6-phospho-beta-galactosidase activity
EGM183_RS09780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS09780	COG1263	PTS System
EGM183_RS09780	COG2190	(PTS) system
EGM183_RS09785	COG3711	transcriptional antiterminator
EGM183_RS09790	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EGM183_RS09795	COG0628	permease
EGM183_RS09810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EGM183_RS09815	COG4836	Membrane
EGM183_RS09820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EGM183_RS09825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EGM183_RS09830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EGM183_RS09835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EGM183_RS09840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGM183_RS09845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EGM183_RS09850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGM183_RS09855	COG0356	it plays a direct role in the translocation of protons across the membrane
EGM183_RS09860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EGM183_RS09865	COG0557	exoribonuclease II activity
EGM183_RS09875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EGM183_RS09880	COG2388	GCN5-related N-acetyl-transferase
EGM183_RS09885	COG3592	Divergent 4Fe-4S mono-cluster
EGM183_RS09895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EGM183_RS09900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EGM183_RS09905	COG2246	polysaccharide biosynthetic process
EGM183_RS09915	COG3942	CHAP domain
EGM183_RS09915	COG1705	Flagellar rod assembly protein muramidase FlgJ
EGM183_RS09930	COG0459	protein refolding
EGM183_RS09935	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EGM183_RS09950	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EGM183_RS09955	COG0488	(ABC) transporter
EGM183_RS09965	COG4175	Glycine betaine
EGM183_RS09965	COG3448	diguanylate cyclase activity
EGM183_RS09980	COG1597	lipid kinase activity
EGM183_RS09985	COG3835	regulator
EGM183_RS09990	COG1929	Belongs to the glycerate kinase type-1 family
EGM183_RS09995	COG2610	gluconate transmembrane transporter activity
EGM183_RS10000	COG0398	Pfam SNARE associated Golgi protein
EGM183_RS10005	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EGM183_RS10010	COG1177	transmembrane transport
EGM183_RS10015	COG1176	ABC-type spermidine putrescine transport system, permease component I
EGM183_RS10020	COG3842	ATPase activity
EGM183_RS10030	COG0604	alcohol dehydrogenase
EGM183_RS10040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EGM183_RS10045	COG4684	Psort location CytoplasmicMembrane, score
EGM183_RS10050	COG2348	transferase activity, transferring amino-acyl groups
EGM183_RS10065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGM183_RS10075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EGM183_RS10085	COG3142	Participates in the control of copper homeostasis
EGM183_RS10090	COG2239	Acts as a magnesium transporter
EGM183_RS10095	COG0564	pseudouridine synthase activity
EGM183_RS10100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EGM183_RS10105	COG2357	RelA SpoT domain protein
EGM183_RS10110	COG4116	CYTH
EGM183_RS10120	COG1164	Oligoendopeptidase f
EGM183_RS10130	COG4862	establishment of competence for transformation
EGM183_RS10135	COG1393	Belongs to the ArsC family
EGM183_RS10140	COG0180	Tryptophanyl-tRNA synthetase
EGM183_RS10145	COG1132	(ABC) transporter
EGM183_RS10195	COG0419	ATPase involved in DNA repair
EGM183_RS10200	COG0420	3'-5' exonuclease activity
EGM183_RS10205	COG0204	Acyl-transferase
EGM183_RS10210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EGM183_RS10215	COG2827	Endonuclease containing a URI domain
EGM183_RS10220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EGM183_RS10230	COG0494	nUDIX hydrolase
EGM183_RS10240	COG3853	Toxic anion resistance protein (TelA)
EGM183_RS10265	COG1194	a g-specific adenine glycosylase
EGM183_RS10270	COG2137	regulation of response to DNA damage stimulus
EGM183_RS10275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGM183_RS10280	COG2261	transglycosylase associated protein
EGM183_RS10285	COG3250	beta-galactosidase activity
EGM183_RS10290	COG0531	amino acid
EGM183_RS10295	COG1917	Cupin 2, conserved barrel domain protein
EGM183_RS10295	COG2207	Transcriptional regulator
EGM183_RS10305	COG0222	ribosome binding
EGM183_RS10310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EGM183_RS10315	COG0081	regulation of translation
EGM183_RS10320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EGM183_RS10325	COG0488	(ABC) transporter
EGM183_RS10330	COG1760	l-serine dehydratase
EGM183_RS10335	COG1760	l-serine dehydratase
EGM183_RS10345	COG1363	Peptidase, m42
EGM183_RS10350	COG4166	transmembrane transport
EGM183_RS10365	COG0250	Participates in transcription elongation, termination and antitermination
EGM183_RS10370	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EGM183_RS10375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EGM183_RS10385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EGM183_RS10395	COG0708	Exodeoxyribonuclease III
EGM183_RS10425	COG0095	Lipoate-protein ligase
EGM183_RS10430	COG1234	tRNA 3'-trailer cleavage
EGM183_RS10440	COG1363	Peptidase, m42
EGM183_RS10445	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EGM183_RS10450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGM183_RS10455	COG1696	Membrane protein involved in D-alanine export
EGM183_RS10460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EGM183_RS10470	COG0577	efflux transmembrane transporter activity
EGM183_RS10475	COG1136	(ABC) transporter
EGM183_RS10480	COG1328	CTP reductase activity
EGM183_RS10485	COG0602	queuosine metabolic process
EGM183_RS10495	COG0390	transport system, permease component
EGM183_RS10500	COG4619	ABC transporter
EGM183_RS10510	COG4467	Involved in initiation control of chromosome replication
EGM183_RS10515	COG1774	PSP1 C-terminal conserved region
EGM183_RS10520	COG0470	DNA polymerase III
EGM183_RS10525	COG3870	Protein conserved in bacteria
EGM183_RS10530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EGM183_RS10535	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EGM183_RS10540	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EGM183_RS10550	COG1122	ATPase activity
EGM183_RS10565	COG0477	Major facilitator Superfamily
EGM183_RS10570	COG2814	Major facilitator Superfamily
EGM183_RS10575	COG1733	regulation of RNA biosynthetic process
EGM183_RS10580	COG0351	phosphomethylpyrimidine kinase
EGM183_RS10585	COG0352	thiamine-phosphate diphosphorylase activity
EGM183_RS10590	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EGM183_RS10600	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EGM183_RS10605	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EGM183_RS10610	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EGM183_RS10615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EGM183_RS10630	COG3189	MarR family transcriptional regulator
EGM183_RS10635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EGM183_RS10640	COG1940	carbohydrate kinase activity
EGM183_RS10655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EGM183_RS10660	COG1073	alpha beta
EGM183_RS10695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EGM183_RS10700	COG0768	penicillin binding
EGM183_RS10705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EGM183_RS10710	COG1942	4-Oxalocrotonate Tautomerase
EGM183_RS10715	COG1876	peptidase activity
EGM183_RS10755	COG0217	transcriptional regulatory protein
EGM183_RS10760	COG1323	Belongs to the UPF0348 family
EGM183_RS10765	COG2226	methyltransferase
EGM183_RS10770	COG0799	negative regulation of ribosome biogenesis
EGM183_RS10775	COG1713	HD superfamily hydrolase involved in NAD metabolism
EGM183_RS10780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EGM183_RS10785	COG1534	Rna-binding protein
EGM183_RS10790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EGM183_RS10800	COG0825	malonyl-CoA metabolic process
EGM183_RS10805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EGM183_RS10810	COG0439	Biotin carboxylase
EGM183_RS10815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGM183_RS10825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGM183_RS10835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EGM183_RS10850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EGM183_RS10855	COG1846	Transcriptional regulator
EGM183_RS10860	COG4703	Protein of unknown function (DUF1797)
EGM183_RS10865	COG2084	Dehydrogenase
EGM183_RS10870	COG0438	transferase activity, transferring glycosyl groups
EGM183_RS10915	COG1098	S1 RNA binding domain
EGM183_RS10920	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EGM183_RS10935	COG0492	ferredoxin-NADP+ reductase activity
EGM183_RS10945	COG0737	Belongs to the 5'-nucleotidase family
EGM183_RS10965	COG1175	transmembrane transport
EGM183_RS10970	COG3842	ATPase activity
EGM183_RS10975	COG0463	Glycosyl transferase, family 2
EGM183_RS10980	COG4841	protein insertion into membrane
EGM183_RS10985	COG0569	domain protein
EGM183_RS10990	COG2197	response regulator
EGM183_RS10995	COG4585	Histidine kinase
EGM183_RS11005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGM183_RS11010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EGM183_RS11020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EGM183_RS11025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EGM183_RS11040	COG2832	Protein of unknown function (DUF454)
EGM183_RS11045	COG5503	Protein of unknown function (DUF1447)
EGM183_RS11055	COG1278	Cold shock
EGM183_RS11060	COG2003	Belongs to the UPF0758 family
EGM183_RS11065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGM183_RS11070	COG0285	dihydrofolate synthase activity
EGM183_RS11085	COG0525	valine-tRNA ligase activity
EGM183_RS11090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EGM183_RS11095	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EGM183_RS11100	COG0301	tRNA thio-modification
EGM183_RS11105	COG2252	PERMEase
EGM183_RS11110	COG4221	oxidoreductase activity
EGM183_RS11115	COG0110	maltose O-acetyltransferase activity
EGM183_RS11120	COG0583	DNA-binding transcription factor activity
EGM183_RS11125	COG4975	Glucose uptake
EGM183_RS11130	COG1869	D-ribose catabolic process
EGM183_RS11140	COG1609	Transcriptional regulator
EGM183_RS11145	COG0657	acetylesterase activity
EGM183_RS11160	COG3711	transcriptional antiterminator
EGM183_RS11185	COG1834	amidinotransferase
EGM183_RS11190	COG1785	Belongs to the alkaline phosphatase family
EGM183_RS11195	COG1193	negative regulation of DNA recombination
EGM183_RS11210	COG3716	PTS system mannose fructose sorbose family IID component
EGM183_RS11215	COG3715	PTS system
EGM183_RS11220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS11250	COG0577	efflux transmembrane transporter activity
EGM183_RS11255	COG1136	(ABC) transporter
EGM183_RS11260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGM183_RS11270	COG0446	pyridine nucleotide-disulphide oxidoreductase
EGM183_RS11280	COG1937	Protein conserved in bacteria
EGM183_RS11290	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EGM183_RS11295	COG2508	Transcriptional regulator
EGM183_RS11300	COG3257	ureidoglycine aminohydrolase activity
EGM183_RS11305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGM183_RS11310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EGM183_RS11315	COG1953	Uracil, thiamine, allantoin
EGM183_RS11350	COG1846	Transcriptional regulator
EGM183_RS11360	COG0659	secondary active sulfate transmembrane transporter activity
EGM183_RS11365	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EGM183_RS11370	COG2723	6-phospho-beta-galactosidase activity
EGM183_RS11375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS11400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EGM183_RS11405	COG1304	FMN binding
EGM183_RS11420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EGM183_RS11425	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EGM183_RS11460	COG1823	symporter activity
EGM183_RS11480	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EGM183_RS11485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGM183_RS11490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EGM183_RS11500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGM183_RS11505	COG1363	Peptidase, m42
EGM183_RS11515	COG4166	transmembrane transport
EGM183_RS11520	COG3716	PTS system mannose fructose sorbose family IID component
EGM183_RS11525	COG3715	PTS system
EGM183_RS11530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EGM183_RS11535	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS11550	COG3394	polysaccharide catabolic process
EGM183_RS11560	COG0519	Catalyzes the synthesis of GMP from XMP
EGM183_RS11595	COG3764	Sortase (surface protein transpeptidase)
EGM183_RS11605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGM183_RS11630	COG1185	polyribonucleotide nucleotidyltransferase activity
EGM183_RS11635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EGM183_RS11640	COG0242	peptide deformylase activity
EGM183_RS11660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EGM183_RS11665	COG1268	BioY protein
EGM183_RS11685	COG4493	Belongs to the UPF0637 family
EGM183_RS11695	COG2195	Cleaves the N-terminal amino acid of tripeptides
EGM183_RS11700	COG4166	transmembrane transport
EGM183_RS11705	COG4607	ABC-type enterochelin transport system periplasmic component
EGM183_RS11710	COG4604	ABC transporter, ATP-binding protein
EGM183_RS11715	COG4605	iron ion homeostasis
EGM183_RS11720	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGM183_RS11735	COG2918	glutathione biosynthetic process
EGM183_RS11735	COG1181	Belongs to the D-alanine--D-alanine ligase family
EGM183_RS11745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EGM183_RS11760	COG0552	protein localization to endoplasmic reticulum
EGM183_RS11765	COG0561	phosphatase activity
EGM183_RS11770	COG1196	nuclear chromosome segregation
EGM183_RS11775	COG0571	ribonuclease III activity
EGM183_RS11790	COG0601	transmembrane transport
EGM183_RS11795	COG4608	Belongs to the ABC transporter superfamily
EGM183_RS11805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGM183_RS11810	COG0416	fatty acid biosynthetic process
EGM183_RS11815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EGM183_RS11820	COG1461	Dihydroxyacetone kinase
EGM183_RS11830	COG3279	Response regulator of the LytR AlgR family
EGM183_RS11840	COG1668	transmembrane transport
EGM183_RS11845	COG4152	abc transporter atp-binding protein
EGM183_RS11850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EGM183_RS11860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EGM183_RS11865	COG1162	GTPase activity
EGM183_RS11870	COG0515	serine threonine protein kinase
EGM183_RS11870	COG2815	serine threonine protein kinase
EGM183_RS11880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGM183_RS11880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGM183_RS11885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EGM183_RS11895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EGM183_RS11900	COG1758	RNA polymerase activity
EGM183_RS11905	COG0194	GDP metabolic process
EGM183_RS11935	COG0800	Aldolase
EGM183_RS11940	COG1312	Catalyzes the dehydration of D-mannonate
EGM183_RS11950	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EGM183_RS11955	COG3716	PTS system mannose fructose sorbose family IID component
EGM183_RS11965	COG0371	Dehydrogenase
EGM183_RS11975	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EGM183_RS11980	COG1737	Transcriptional regulator
EGM183_RS11990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EGM183_RS12020	COG1426	Protein conserved in bacteria
EGM183_RS12025	COG0612	Peptidase, M16
EGM183_RS12030	COG0612	Peptidase, M16
EGM183_RS12035	COG1970	mechanosensitive ion channel activity
EGM183_RS12045	COG2188	Transcriptional regulator
EGM183_RS12050	COG1554	hydrolase, family 65, central catalytic
EGM183_RS12055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGM183_RS12070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EGM183_RS12080	COG0424	maF-like protein
EGM183_RS12085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EGM183_RS12090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EGM183_RS12095	COG4550	Control of competence regulator ComK, YlbF/YmcA
EGM183_RS12100	COG1692	metallophosphoesterase
EGM183_RS12105	COG1418	mRNA catabolic process
EGM183_RS12110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EGM183_RS12115	COG1058	Belongs to the CinA family
EGM183_RS12115	COG1546	Belongs to the CinA family
EGM183_RS12120	COG2433	Pfam Transposase IS66
EGM183_RS12125	COG2910	NAD(P)H-binding
EGM183_RS12130	COG1959	2 iron, 2 sulfur cluster binding
EGM183_RS12145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGM183_RS12205	COG1335	isochorismatase
EGM183_RS12210	COG1346	cytolysis
EGM183_RS12220	COG3279	Response regulator of the LytR AlgR family
EGM183_RS12225	COG3275	phosphorelay sensor kinase activity
EGM183_RS12235	COG2011	ABC-type metal ion transport system permease component
EGM183_RS12250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EGM183_RS12255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EGM183_RS12270	COG3443	Belongs to the bacterial solute-binding protein 9 family
EGM183_RS12270	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGM183_RS12275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGM183_RS12280	COG0842	Transport permease protein
EGM183_RS12285	COG1131	(ABC) transporter
EGM183_RS12300	COG3715	PTS system
EGM183_RS12305	COG3716	PTS system mannose fructose sorbose family IID component
EGM183_RS12320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EGM183_RS12325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EGM183_RS12330	COG0783	Belongs to the Dps family
EGM183_RS12340	COG1070	Carbohydrate kinase
EGM183_RS12345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EGM183_RS12350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EGM183_RS12355	COG0085	RNA polymerase activity
EGM183_RS12360	COG1131	(ABC) transporter
EGM183_RS12390	COG1316	TRANSCRIPTIONal
EGM183_RS12405	COG1575	Belongs to the MenA family. Type 1 subfamily
EGM183_RS12415	COG4939	FMN-binding domain protein
EGM183_RS12435	COG0142	geranyltranstransferase activity
EGM183_RS12445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EGM183_RS12450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EGM183_RS12455	COG0302	gtp cyclohydrolase
EGM183_RS12465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EGM183_RS12470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGM183_RS12505	COG2508	Transcriptional regulator
EGM183_RS12505	COG2508	Transcriptional regulator
EGM183_RS12510	COG0826	peptidase U32
EGM183_RS12515	COG0826	peptidase U32
EGM183_RS12525	COG0542	response to heat
EGM183_RS12530	COG4463	regulation of RNA biosynthetic process
EGM183_RS12535	COG0626	cystathionine gamma-synthase activity
EGM183_RS12540	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EGM183_RS12545	COG1737	Transcriptional regulator
EGM183_RS12615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EGM183_RS12620	COG0516	GMP reductase activity
EGM183_RS12620	COG0517	IMP dehydrogenase activity
EGM183_RS12635	COG0012	GTP binding
EGM183_RS12640	COG4481	Protein conserved in bacteria
EGM183_RS12645	COG1475	DNA binding
EGM183_RS12650	COG1192	Involved in chromosome partitioning
EGM183_RS12655	COG0357	Ribosomal RNA small subunit methyltransferase G
EGM183_RS12680	COG3732	PTS system glucitol sorbitol-specific
EGM183_RS12685	COG3730	PTS system glucitol sorbitol-specific
EGM183_RS12705	COG0445	tRNA wobble uridine modification
EGM183_RS12710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGM183_RS12720	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EGM183_RS12750	COG3052	prosthetic group binding
EGM183_RS12755	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EGM183_RS12760	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EGM183_RS12765	COG0511	ligase activity, forming carbon-carbon bonds
EGM183_RS12775	COG2851	Citrate transporter
EGM183_RS12785	COG0745	RESPONSE REGULATOR receiver
EGM183_RS12795	COG0706	membrane insertase activity
EGM183_RS12800	COG0594	ribonuclease P activity
EGM183_RS12805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EGM183_RS12850	COG3843	relaxase mobilization nuclease domain protein
EGM183_RS12885	COG1674	ftsk spoiiie
EGM183_RS12895	COG2946	Replication initiation factor
EGM183_RS12925	COG0791	NLP P60 protein
EGM183_RS12925	COG0741	lytic transglycosylase activity
EGM183_RS12990	COG1192	Involved in chromosome partitioning
EGM183_RS13045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EGM183_RS13110	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGM183_RS13115	COG0022	dehydrogenase e1 component
EGM183_RS13120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EGM183_RS13125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGM183_RS13130	COG3284	Transcriptional regulator
EGM183_RS13135	COG0551	DNA topoisomerase type I activity
EGM183_RS13135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone