locus-tag	class	description
A3777_RS00010	COG0205	6-phosphofructokinase activity
A3777_RS00025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A3777_RS00030	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A3777_RS00035	COG0745	RESPONSE REGULATOR receiver
A3777_RS00040	COG5002	protein histidine kinase activity
A3777_RS00135	COG1116	anion transmembrane transporter activity
A3777_RS00140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3777_RS00145	COG1660	Displays ATPase and GTPase activities
A3777_RS00150	COG1914	H( )-stimulated, divalent metal cation uptake system
A3777_RS00160	COG2508	Transcriptional regulator
A3777_RS00165	COG4166	transmembrane transport
A3777_RS00170	COG0402	S-adenosylhomocysteine deaminase activity
A3777_RS00175	COG0402	S-adenosylhomocysteine deaminase activity
A3777_RS00180	COG1956	GAF domain-containing protein
A3777_RS00190	COG0110	maltose O-acetyltransferase activity
A3777_RS00205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A3777_RS00210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3777_RS00215	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A3777_RS00220	COG1609	Transcriptional regulator
A3777_RS00225	COG0572	uridine kinase
A3777_RS00250	COG2814	Major facilitator Superfamily
A3777_RS00255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A3777_RS00285	COG0456	acetyltransferase
A3777_RS00365	COG1132	(ABC) transporter
A3777_RS00380	COG1113	amino acid transport
A3777_RS00400	COG0247	lactate metabolic process
A3777_RS00405	COG1139	Iron-sulfur cluster binding protein
A3777_RS00420	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A3777_RS00425	COG1074	ATP-dependent DNA helicase activity
A3777_RS00430	COG1733	regulation of RNA biosynthetic process
A3777_RS00435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A3777_RS00440	COG0072	phenylalanine-tRNA ligase activity
A3777_RS00440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3777_RS00445	COG0765	amino acid transport
A3777_RS00450	COG0765	amino acid transport
A3777_RS00455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3777_RS00465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A3777_RS00470	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A3777_RS00475	COG0622	Phosphoesterase
A3777_RS00480	COG1349	DNA-binding transcription factor activity
A3777_RS00490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS00495	COG3037	sugar-specific permease SgaT UlaA
A3777_RS00505	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A3777_RS00510	COG3623	hexulose-6-phosphate isomerase
A3777_RS00520	COG0517	IMP dehydrogenase activity
A3777_RS00525	COG2171	N-acyltransferase activity
A3777_RS00530	COG1473	amidohydrolase
A3777_RS00535	COG0668	transmembrane transport
A3777_RS00545	COG0656	L-ascorbic acid biosynthetic process
A3777_RS00570	COG1078	dGTPase activity
A3777_RS00575	COG0095	Lipoate-protein ligase
A3777_RS00590	COG0504	CTP synthase activity
A3777_RS00595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3777_RS00600	COG3331	DNA recombination
A3777_RS00605	COG4474	Belongs to the UPF0398 family
A3777_RS00610	COG3599	regulation of cell shape
A3777_RS00620	COG0116	Belongs to the methyltransferase superfamily
A3777_RS00625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A3777_RS00630	COG3935	DnaD domain protein
A3777_RS00635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3777_RS00640	COG2188	Transcriptional regulator
A3777_RS00650	COG1446	asparaginase
A3777_RS00655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS00660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS00685	COG1666	GTP binding
A3777_RS00690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A3777_RS00695	COG0191	fructose-bisphosphate aldolase activity
A3777_RS00705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A3777_RS00710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A3777_RS00715	COG0254	rRNA binding
A3777_RS00725	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A3777_RS00735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A3777_RS00750	COG1940	carbohydrate kinase activity
A3777_RS00760	COG0778	Nitroreductase
A3777_RS00765	COG1854	S-ribosylhomocysteine lyase activity
A3777_RS00770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A3777_RS00775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3777_RS00785	COG0737	Belongs to the 5'-nucleotidase family
A3777_RS00790	COG4470	Protein conserved in bacteria
A3777_RS00795	COG0647	UMP catabolic process
A3777_RS00810	COG1307	EDD domain protein, DegV family
A3777_RS00815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A3777_RS00820	COG0745	RESPONSE REGULATOR receiver
A3777_RS00825	COG5002	protein histidine kinase activity
A3777_RS00840	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A3777_RS00845	COG0701	Predicted permease
A3777_RS00850	COG3689	TIGRFAM TIGR03943 family protein
A3777_RS00865	COG4472	Bacterial protein of unknown function (DUF965)
A3777_RS00870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A3777_RS00875	COG3906	Belongs to the UPF0473 family
A3777_RS00890	COG3493	citrate carrier protein
A3777_RS00895	COG3290	protein histidine kinase activity
A3777_RS00900	COG4565	transcriptional regulatory protein
A3777_RS00905	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3777_RS00910	COG1316	TRANSCRIPTIONal
A3777_RS00915	COG0028	Belongs to the TPP enzyme family
A3777_RS00920	COG3527	Alpha-acetolactate decarboxylase
A3777_RS00940	COG1175	transmembrane transport
A3777_RS00950	COG3842	ATPase activity
A3777_RS00960	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A3777_RS00965	COG0402	S-adenosylhomocysteine deaminase activity
A3777_RS00985	COG0431	NADPH-dependent FMN reductase
A3777_RS00985	COG1053	succinate dehydrogenase
A3777_RS00985	COG3976	FMN-binding domain protein
A3777_RS01005	COG1408	metallophosphoesterase
A3777_RS01010	COG4209	transmembrane transport
A3777_RS01015	COG0395	ABC-type sugar transport system, permease component
A3777_RS01030	COG3458	cephalosporin-C deacetylase activity
A3777_RS01045	COG3459	Glycosyltransferase 36 associated
A3777_RS01050	COG1609	Transcriptional regulator
A3777_RS01060	COG2188	Transcriptional regulator
A3777_RS01065	COG2723	6-phospho-beta-galactosidase activity
A3777_RS01070	COG0673	inositol 2-dehydrogenase activity
A3777_RS01075	COG2707	UPF0756 membrane protein
A3777_RS01090	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A3777_RS01115	COG1122	ATPase activity
A3777_RS01135	COG0561	phosphatase activity
A3777_RS01140	COG0745	RESPONSE REGULATOR receiver
A3777_RS01145	COG5002	protein histidine kinase activity
A3777_RS01145	COG3850	Histidine kinase
A3777_RS01160	COG1368	sulfuric ester hydrolase activity
A3777_RS01165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A3777_RS01170	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A3777_RS01175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3777_RS01180	COG4932	domain protein
A3777_RS01180	COG1388	LysM domain
A3777_RS01185	COG0779	Required for maturation of 30S ribosomal subunits
A3777_RS01190	COG0195	Participates in both transcription termination and antitermination
A3777_RS01195	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A3777_RS01205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A3777_RS01210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A3777_RS01295	COG4824	toxin secretion phage lysis holin
A3777_RS01305	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A3777_RS01310	COG0196	riboflavin kinase activity
A3777_RS01320	COG1695	Transcriptional regulator
A3777_RS01340	COG0772	Belongs to the SEDS family
A3777_RS01345	COG0583	DNA-binding transcription factor activity
A3777_RS01350	COG0583	DNA-binding transcription factor activity
A3777_RS01355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3777_RS01360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3777_RS01365	COG1420	regulation of RNA biosynthetic process
A3777_RS01370	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A3777_RS01375	COG0443	Heat shock 70 kDa protein
A3777_RS01385	COG0484	heat shock protein binding
A3777_RS01395	COG2183	response to ionizing radiation
A3777_RS01400	COG3091	SprT-like family
A3777_RS01410	COG0436	Aminotransferase
A3777_RS01455	COG2268	Band 7 protein
A3777_RS01480	COG1309	transcriptional regulator
A3777_RS01490	COG2188	Transcriptional regulator
A3777_RS01495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A3777_RS01515	COG1129	ABC transporter
A3777_RS01535	COG3290	protein histidine kinase activity
A3777_RS01540	COG3279	Response regulator of the LytR AlgR family
A3777_RS01550	COG0492	ferredoxin-NADP+ reductase activity
A3777_RS01565	COG0577	efflux transmembrane transporter activity
A3777_RS01565	COG1136	(ABC) transporter
A3777_RS01565	COG0577	efflux transmembrane transporter activity
A3777_RS01565	COG1136	(ABC) transporter
A3777_RS01575	COG3833	ABC-type maltose transport systems, permease component
A3777_RS01580	COG1175	transmembrane transport
A3777_RS01585	COG2182	Extracellular solute-binding protein
A3777_RS01595	COG0366	Alpha amylase catalytic
A3777_RS01600	COG0366	Alpha amylase catalytic
A3777_RS01605	COG0366	Alpha amylase catalytic
A3777_RS01615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3777_RS01640	COG2207	Transcriptional regulator
A3777_RS01645	COG0371	Dehydrogenase
A3777_RS01650	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A3777_RS01655	COG2376	Dihydroxyacetone kinase
A3777_RS01660	COG1461	Dihydroxyacetone kinase
A3777_RS01670	COG3425	synthase
A3777_RS01685	COG0628	permease
A3777_RS01695	COG1278	Cold shock
A3777_RS01715	COG1121	(ABC) transporter
A3777_RS01730	COG2814	Major facilitator Superfamily
A3777_RS01735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3777_RS01740	COG4109	DRTGG domain
A3777_RS01745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A3777_RS01750	COG2824	Alkylphosphonate utilization operon protein PhnA
A3777_RS01765	COG0513	Belongs to the DEAD box helicase family
A3777_RS01775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3777_RS01780	COG2384	SAM-dependent methyltransferase
A3777_RS01785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A3777_RS01790	COG2195	Cleaves the N-terminal amino acid of tripeptides
A3777_RS01805	COG0746	molybdenum cofactor guanylyltransferase activity
A3777_RS01810	COG2116	formate transmembrane transporter activity
A3777_RS01825	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A3777_RS01835	COG0303	'Molybdopterin
A3777_RS01840	COG0315	cyclic pyranopterin monophosphate synthase activity
A3777_RS01855	COG0521	Mo-molybdopterin cofactor biosynthetic process
A3777_RS01865	COG0725	ABC transporter, periplasmic molybdate-binding protein
A3777_RS01870	COG4149	molybdate abc transporter
A3777_RS01875	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A3777_RS01880	COG2217	Heavy metal translocating P-type atpase
A3777_RS01895	COG1286	toxin biosynthetic process
A3777_RS01900	COG1193	negative regulation of DNA recombination
A3777_RS01905	COG3118	belongs to the thioredoxin family
A3777_RS01910	COG0322	excinuclease ABC activity
A3777_RS01920	COG4152	abc transporter atp-binding protein
A3777_RS01925	COG1668	transmembrane transport
A3777_RS01930	COG1609	Transcriptional regulator
A3777_RS01935	COG1486	melibiose metabolic process
A3777_RS01950	COG2081	HI0933 family
A3777_RS01955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A3777_RS01960	COG0166	Belongs to the GPI family
A3777_RS01980	COG1269	ATP hydrolysis coupled proton transport
A3777_RS01985	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A3777_RS01990	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
A3777_RS01995	COG1527	subunit (C
A3777_RS02000	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
A3777_RS02005	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A3777_RS02010	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A3777_RS02015	COG1394	ATPase activity, coupled to movement of substances
A3777_RS02040	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A3777_RS02045	COG0019	diaminopimelate decarboxylase activity
A3777_RS02070	COG2151	metal-sulfur cluster biosynthetic enzyme
A3777_RS02075	COG4948	Mandelate Racemase Muconate Lactonizing
A3777_RS02085	COG3711	transcriptional antiterminator
A3777_RS02095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS02095	COG3711	transcriptional antiterminator
A3777_RS02105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3777_RS02105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3777_RS02105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS02110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS02120	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A3777_RS02130	COG0741	lytic transglycosylase activity
A3777_RS02135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3777_RS02140	COG0358	DNA primase activity
A3777_RS02145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A3777_RS02155	COG2996	Protein conserved in bacteria
A3777_RS02160	COG0735	belongs to the Fur family
A3777_RS02170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3777_RS02180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS02200	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A3777_RS02215	COG4974	Belongs to the 'phage' integrase family
A3777_RS02220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A3777_RS02225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A3777_RS02230	COG1187	pseudouridine synthase activity
A3777_RS02235	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A3777_RS02255	COG0514	ATP-dependent DNA helicase (RecQ)
A3777_RS02265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A3777_RS02270	COG0539	negative regulation of cytoplasmic translation
A3777_RS02275	COG1160	GTP binding
A3777_RS02290	COG0457	Tetratricopeptide repeat
A3777_RS02295	COG5582	Belongs to the UPF0302 family
A3777_RS02300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A3777_RS02305	COG1694	Mazg nucleotide pyrophosphohydrolase
A3777_RS02310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A3777_RS02315	COG0617	tRNA 3'-terminal CCA addition
A3777_RS02330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A3777_RS02335	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A3777_RS02345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A3777_RS02350	COG0287	Prephenate dehydrogenase
A3777_RS02360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A3777_RS02365	COG0077	Prephenate dehydratase
A3777_RS02375	COG1307	EDD domain protein, DegV family
A3777_RS02400	COG0488	(ABC) transporter
A3777_RS02405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A3777_RS02415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A3777_RS02420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A3777_RS02425	COG4224	UPF0291 protein
A3777_RS02435	COG2814	Major facilitator Superfamily
A3777_RS02440	COG1388	LysM domain
A3777_RS02440	COG1705	Flagellar rod assembly protein muramidase FlgJ
A3777_RS02450	COG0735	belongs to the Fur family
A3777_RS02455	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3777_RS02460	COG2816	NAD+ diphosphatase activity
A3777_RS02475	COG2207	Transcriptional regulator
A3777_RS02480	COG1132	(ABC) transporter
A3777_RS02485	COG1132	(ABC) transporter
A3777_RS02510	COG0415	Belongs to the DNA photolyase family
A3777_RS02525	COG0366	Alpha amylase catalytic
A3777_RS02535	COG1609	Transcriptional regulator
A3777_RS02545	COG2723	6-phospho-beta-galactosidase activity
A3777_RS02550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS02550	COG2190	(PTS) system
A3777_RS02550	COG1263	PTS System
A3777_RS02555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A3777_RS02560	COG3639	organic phosphonate transmembrane transporter activity
A3777_RS02575	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A3777_RS02590	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A3777_RS02600	COG1227	inorganic diphosphatase activity
A3777_RS02605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A3777_RS02610	COG1882	Formate acetyltransferase
A3777_RS02615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A3777_RS02620	COG0187	DNA topoisomerase II activity
A3777_RS02625	COG1832	CoA-binding protein
A3777_RS02630	COG4766	ethanolamine catabolic process
A3777_RS02635	COG3192	ethanolamine utilization protein
A3777_RS02640	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A3777_RS02650	COG4869	propanediol catabolic process
A3777_RS02665	COG1454	alcohol dehydrogenase
A3777_RS02665	COG1012	belongs to the aldehyde dehydrogenase family
A3777_RS02680	COG4302	ethanolamine ammonia-lyase activity
A3777_RS02685	COG4303	Ethanolamine ammonia lyase large subunit
A3777_RS02715	COG2096	Adenosyltransferase
A3777_RS02725	COG1120	ATPase activity
A3777_RS02730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3777_RS02735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3777_RS02740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A3777_RS02750	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A3777_RS02755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A3777_RS02760	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A3777_RS02770	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A3777_RS02775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3777_RS02780	COG1266	CAAX protease self-immunity
A3777_RS02785	COG0758	DNA mediated transformation
A3777_RS02790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A3777_RS02800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3777_RS02805	COG0583	DNA-binding transcription factor activity
A3777_RS02815	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3777_RS02820	COG0022	dehydrogenase e1 component
A3777_RS02825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A3777_RS02830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3777_RS02835	COG3426	butyrate kinase activity
A3777_RS02840	COG0280	phosphate acetyltransferase
A3777_RS02860	COG1028	Short-chain dehydrogenase reductase Sdr
A3777_RS02870	COG0346	lactoylglutathione lyase activity
A3777_RS02880	COG0604	alcohol dehydrogenase
A3777_RS02885	COG0577	efflux transmembrane transporter activity
A3777_RS02890	COG1136	(ABC) transporter
A3777_RS02900	COG1131	(ABC) transporter
A3777_RS02915	COG0681	Belongs to the peptidase S26 family
A3777_RS02920	COG0793	Belongs to the peptidase S41A family
A3777_RS02920	COG3409	Peptidoglycan-binding domain 1 protein
A3777_RS02925	COG4479	Belongs to the UPF0346 family
A3777_RS02930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3777_RS02935	COG4698	Protein conserved in bacteria
A3777_RS02940	COG2755	lipolytic protein G-D-S-L family
A3777_RS02945	COG1307	EDD domain protein, DegV family
A3777_RS02950	COG1272	protein, Hemolysin III
A3777_RS02960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3777_RS02965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A3777_RS02965	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A3777_RS02970	COG5416	Lipopolysaccharide assembly protein A domain
A3777_RS02975	COG0300	oxidoreductase activity
A3777_RS02980	COG1234	tRNA 3'-trailer cleavage
A3777_RS02990	COG1837	Belongs to the UPF0109 family
A3777_RS02995	COG0228	four-way junction DNA binding
A3777_RS03000	COG0456	acetyltransferase
A3777_RS03000	COG1214	PFAM Peptidase M22, glycoprotease
A3777_RS03005	COG0431	NADPH-dependent FMN reductase
A3777_RS03010	COG0789	Transcriptional regulator
A3777_RS03015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3777_RS03020	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A3777_RS03025	COG1683	Conserved Protein
A3777_RS03030	COG0745	RESPONSE REGULATOR receiver
A3777_RS03035	COG5002	protein histidine kinase activity
A3777_RS03045	COG0436	Aminotransferase
A3777_RS03050	COG0383	alpha-mannosidase activity
A3777_RS03065	COG0583	DNA-binding transcription factor activity
A3777_RS03080	COG0284	orotidine-5'-phosphate decarboxylase activity
A3777_RS03090	COG0543	2 iron, 2 sulfur cluster binding
A3777_RS03095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A3777_RS03100	COG0505	Belongs to the CarA family
A3777_RS03105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A3777_RS03110	COG0540	Belongs to the ATCase OTCase family
A3777_RS03115	COG2233	PERMEase
A3777_RS03125	COG0564	pseudouridine synthase activity
A3777_RS03130	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A3777_RS03140	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A3777_RS03145	COG1278	Cold shock
A3777_RS03155	COG0328	RNA-DNA hybrid ribonuclease activity
A3777_RS03160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A3777_RS03165	COG0710	3-dehydroquinate dehydratase activity
A3777_RS03170	COG1132	(ABC) transporter
A3777_RS03175	COG1132	(ABC) transporter
A3777_RS03180	COG3763	UPF0154 protein
A3777_RS03190	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A3777_RS03210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A3777_RS03230	COG1131	(ABC) transporter
A3777_RS03235	COG1609	Transcriptional regulator
A3777_RS03240	COG0006	proline dipeptidase activity
A3777_RS03245	COG4980	gas vesicle protein
A3777_RS03255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A3777_RS03260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A3777_RS03265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A3777_RS03270	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A3777_RS03275	COG0322	excinuclease ABC activity
A3777_RS03280	COG1950	PFAM Membrane protein of
A3777_RS03290	COG3595	metallopeptidase activity
A3777_RS03295	COG0704	Plays a role in the regulation of phosphate uptake
A3777_RS03300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A3777_RS03305	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A3777_RS03310	COG0581	inorganic phosphate transmembrane transporter activity
A3777_RS03315	COG0573	inorganic phosphate transmembrane transporter activity
A3777_RS03325	COG2177	Part of the ABC transporter FtsEX involved in
A3777_RS03330	COG2884	Cell division ATP-binding protein ftsE
A3777_RS03335	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A3777_RS03340	COG0653	protein targeting
A3777_RS03360	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS03370	COG1739	Uncharacterized protein family UPF0029
A3777_RS03380	COG1028	Short-chain dehydrogenase reductase Sdr
A3777_RS03400	COG0151	Belongs to the GarS family
A3777_RS03405	COG0138	bifunctional purine biosynthesis protein purh
A3777_RS03410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A3777_RS03415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A3777_RS03425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3777_RS03430	COG0047	phosphoribosylformylglycinamidine synthase activity
A3777_RS03435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3777_RS03440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3777_RS03445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A3777_RS03450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A3777_RS03460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3777_RS03465	COG4166	transmembrane transport
A3777_RS03475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A3777_RS03480	COG4876	unkown
A3777_RS03495	COG0628	permease
A3777_RS03500	COG1470	cell adhesion involved in biofilm formation
A3777_RS03500	COG0366	Alpha amylase catalytic
A3777_RS03510	COG3716	PTS system mannose fructose sorbose family IID component
A3777_RS03515	COG3715	PTS system
A3777_RS03520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS03520	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS03530	COG1105	Belongs to the carbohydrate kinase PfkB family
A3777_RS03535	COG3684	Belongs to the aldolase LacD family
A3777_RS03540	COG2222	sugar isomerase
A3777_RS03545	COG2188	Transcriptional regulator
A3777_RS03550	COG1442	glycosyl transferase family 8
A3777_RS03555	COG1442	glycosyl transferase family 8
A3777_RS03560	COG1368	sulfuric ester hydrolase activity
A3777_RS03570	COG0583	DNA-binding transcription factor activity
A3777_RS03585	COG3227	Zinc metalloprotease (Elastase)
A3777_RS03600	COG0726	polysaccharide deacetylase
A3777_RS03620	COG4974	Belongs to the 'phage' integrase family
A3777_RS03645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS03655	COG3328	transposase activity
A3777_RS03670	COG2801	Transposase and inactivated derivatives
A3777_RS03675	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A3777_RS03685	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A3777_RS03705	COG3328	transposase activity
A3777_RS03710	COG5002	protein histidine kinase activity
A3777_RS03735	COG1136	(ABC) transporter
A3777_RS03745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A3777_RS03765	COG3328	transposase activity
A3777_RS03775	COG0741	lytic transglycosylase activity
A3777_RS03775	COG0791	NLP P60 protein
A3777_RS03825	COG2946	Replication initiation factor
A3777_RS03840	COG1674	ftsk spoiiie
A3777_RS03850	COG1674	ftsk spoiiie
A3777_RS03880	COG0335	large ribosomal subunit rRNA binding
A3777_RS03885	COG0336	Belongs to the RNA methyltransferase TrmD family
A3777_RS03890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A3777_RS03895	COG1914	H( )-stimulated, divalent metal cation uptake system
A3777_RS03905	COG0398	Pfam SNARE associated Golgi protein
A3777_RS03910	COG0584	glycerophosphoryl diester phosphodiesterase
A3777_RS03925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A3777_RS03935	COG4129	membrane
A3777_RS03945	COG1940	carbohydrate kinase activity
A3777_RS03950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A3777_RS03960	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A3777_RS03965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A3777_RS03970	COG2706	6-phosphogluconolactonase activity
A3777_RS03980	COG3069	C4-dicarboxylate transmembrane transporter activity
A3777_RS04010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A3777_RS04020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A3777_RS04060	COG2364	Membrane
A3777_RS04065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3777_RS04075	COG2814	Major facilitator Superfamily
A3777_RS04080	COG1368	sulfuric ester hydrolase activity
A3777_RS04115	COG3716	PTS system mannose fructose sorbose family IID component
A3777_RS04120	COG3715	PTS system
A3777_RS04135	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A3777_RS04135	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A3777_RS04145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A3777_RS04160	COG0149	triose-phosphate isomerase activity
A3777_RS04165	COG0126	phosphoglycerate kinase activity
A3777_RS04175	COG2390	Transcriptional regulator
A3777_RS04180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A3777_RS04185	COG4475	Protein of unknown function (DUF436)
A3777_RS04190	COG4720	Psort location CytoplasmicMembrane, score
A3777_RS04195	COG0351	phosphomethylpyrimidine kinase
A3777_RS04200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A3777_RS04205	COG0124	histidyl-tRNA synthetase
A3777_RS04215	COG1490	D-aminoacyl-tRNA deacylase activity
A3777_RS04220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3777_RS04225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A3777_RS04230	COG2264	protein methyltransferase activity
A3777_RS04240	COG2094	Belongs to the DNA glycosylase MPG family
A3777_RS04245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3777_RS04265	COG0589	response to stress
A3777_RS04270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A3777_RS04275	COG0827	DNA restriction-modification system
A3777_RS04300	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A3777_RS04315	COG1278	Cold shock
A3777_RS04320	COG1388	LysM domain
A3777_RS04320	COG3942	CHAP domain
A3777_RS04335	COG1783	phage Terminase large subunit
A3777_RS04390	COG1396	sequence-specific DNA binding
A3777_RS04410	COG0582	viral genome integration into host DNA
A3777_RS04420	COG4537	Required for transformation and DNA binding
A3777_RS04430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A3777_RS04435	COG0531	amino acid
A3777_RS04440	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A3777_RS04445	COG0577	efflux transmembrane transporter activity
A3777_RS04450	COG1136	(ABC) transporter
A3777_RS04460	COG1674	ftsk spoiiie
A3777_RS04465	COG1252	NADH dehydrogenase
A3777_RS04480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A3777_RS04485	COG4988	ABC transporter
A3777_RS04490	COG1294	oxidase, subunit
A3777_RS04495	COG1271	oxidase subunit
A3777_RS04500	COG2207	Transcriptional regulator
A3777_RS04500	COG3708	Transcriptional regulator
A3777_RS04520	COG1881	PFAM PEBP family protein
A3777_RS04535	COG0482	sulfurtransferase activity
A3777_RS04545	COG1104	cysteine desulfurase activity
A3777_RS04550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A3777_RS04555	COG1121	(ABC) transporter
A3777_RS04560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3777_RS04570	COG0488	(ABC) transporter
A3777_RS04580	COG1473	amidohydrolase
A3777_RS04590	COG2011	ABC-type metal ion transport system permease component
A3777_RS04595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A3777_RS04640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3777_RS04650	COG1122	ATPase activity
A3777_RS04655	COG4720	Psort location CytoplasmicMembrane, score
A3777_RS04660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3777_RS04670	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A3777_RS04685	COG0789	Transcriptional regulator
A3777_RS04690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3777_RS04695	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A3777_RS04700	COG0584	glycerophosphoryl diester phosphodiesterase
A3777_RS04725	COG1442	glycosyl transferase family 8
A3777_RS04725	COG1216	Glycosyl transferase, family 2
A3777_RS04730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3777_RS04745	COG3475	LICD family
A3777_RS04750	COG1216	Glycosyl transferase, family 2
A3777_RS04755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A3777_RS04770	COG0438	transferase activity, transferring glycosyl groups
A3777_RS04770	COG1216	Glycosyl transferase, family 2
A3777_RS04775	COG1216	Glycosyl transferase, family 2
A3777_RS04775	COG0438	transferase activity, transferring glycosyl groups
A3777_RS04780	COG1134	teichoic acid transport
A3777_RS04785	COG1682	transport, permease protein
A3777_RS04800	COG1215	transferase activity, transferring glycosyl groups
A3777_RS04805	COG1091	dTDP-4-dehydrorhamnose reductase activity
A3777_RS04810	COG1088	dTDP-glucose 4,6-dehydratase activity
A3777_RS04820	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A3777_RS04840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A3777_RS04845	COG1295	ribonuclease BN
A3777_RS04850	COG0024	Methionine aminopeptidase
A3777_RS04855	COG0716	FMN binding
A3777_RS04860	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A3777_RS04865	COG1309	transcriptional regulator
A3777_RS04870	COG2309	aminopeptidase activity
A3777_RS04885	COG0590	tRNA wobble adenosine to inosine editing
A3777_RS04895	COG0384	phenazine biosynthesis protein PhzF
A3777_RS04905	COG2738	Putative neutral zinc metallopeptidase
A3777_RS04920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS04920	COG1263	PTS System
A3777_RS04925	COG0346	lactoylglutathione lyase activity
A3777_RS04945	COG2207	Transcriptional regulator
A3777_RS04945	COG4753	response regulator
A3777_RS04950	COG2972	Histidine kinase
A3777_RS04960	COG1653	transport
A3777_RS04965	COG0395	ABC-type sugar transport system, permease component
A3777_RS04970	COG1175	transmembrane transport
A3777_RS04975	COG1266	CAAX protease self-immunity
A3777_RS04995	COG1132	(ABC) transporter
A3777_RS05005	COG0481	GTPase activity
A3777_RS05020	COG0542	response to heat
A3777_RS05030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A3777_RS05035	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A3777_RS05050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3777_RS05060	COG1705	Flagellar rod assembly protein muramidase FlgJ
A3777_RS05080	COG0017	Asparaginyl-tRNA synthetase
A3777_RS05085	COG0436	Aminotransferase
A3777_RS05095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A3777_RS05095	COG1199	ATP-dependent helicase activity
A3777_RS05105	COG0531	amino acid
A3777_RS05145	COG0442	prolyl-tRNA aminoacylation
A3777_RS05150	COG0750	zinc metalloprotease
A3777_RS05180	COG0149	triose-phosphate isomerase activity
A3777_RS05185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A3777_RS05195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3777_RS05200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3777_RS05205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS05205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3777_RS05205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3777_RS05210	COG3711	transcriptional antiterminator
A3777_RS05235	COG4948	Mandelate Racemase Muconate Lactonizing
A3777_RS05240	COG3775	system Galactitol-specific IIC component
A3777_RS05245	COG3414	Phosphotransferase system galactitol-specific IIB component
A3777_RS05250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS05250	COG2213	PTS system mannitol-specific
A3777_RS05330	COG0719	Fe-S assembly protein
A3777_RS05340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3777_RS05345	COG0719	Fe-S assembly protein
A3777_RS05355	COG0233	cytoplasmic translational termination
A3777_RS05360	COG0528	UMP kinase activity
A3777_RS05365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A3777_RS05370	COG0052	Belongs to the universal ribosomal protein uS2 family
A3777_RS05380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A3777_RS05385	COG1254	Belongs to the acylphosphatase family
A3777_RS05390	COG0706	membrane insertase activity
A3777_RS05400	COG0751	glycine-tRNA ligase activity
A3777_RS05405	COG0752	glycyl-tRNA synthetase alpha subunit
A3777_RS05410	COG1381	Involved in DNA repair and RecF pathway recombination
A3777_RS05415	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A3777_RS05420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A3777_RS05425	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A3777_RS05435	COG1702	phosphate starvation-inducible protein PhoH
A3777_RS05440	COG1610	YqeY-like protein
A3777_RS05445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A3777_RS05450	COG0735	belongs to the Fur family
A3777_RS05455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A3777_RS05460	COG0083	homoserine kinase activity
A3777_RS05470	COG0460	homoserine dehydrogenase
A3777_RS05475	COG0640	Transcriptional regulator
A3777_RS05480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A3777_RS05485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3777_RS05490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3777_RS05505	COG0516	GMP reductase activity
A3777_RS05530	COG1737	Transcriptional regulator
A3777_RS05535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS05535	COG1263	PTS System
A3777_RS05540	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A3777_RS05550	COG2190	(PTS) system
A3777_RS05550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS05550	COG1263	PTS System
A3777_RS05555	COG1968	undecaprenyl-diphosphatase activity
A3777_RS05560	COG3394	polysaccharide catabolic process
A3777_RS05570	COG0306	phosphate transporter
A3777_RS05575	COG0268	Binds directly to 16S ribosomal RNA
A3777_RS05580	COG1607	acyl-coa hydrolase
A3777_RS05585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3777_RS05590	COG1466	dna polymerase III delta subunit
A3777_RS05595	COG2333	competence protein COMEC
A3777_RS05595	COG0658	competence protein
A3777_RS05605	COG2131	deaminase
A3777_RS05610	COG1555	photosystem II stabilization
A3777_RS05615	COG3480	Lon protease (S16) C-terminal proteolytic domain
A3777_RS05620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A3777_RS05625	COG0742	ribosomal rna small subunit methyltransferase
A3777_RS05630	COG4471	UPF0298 protein
A3777_RS05645	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A3777_RS05650	COG0772	Belongs to the SEDS family
A3777_RS05655	COG4838	Belongs to the UPF0358 family
A3777_RS05660	COG0514	ATP-dependent DNA helicase (RecQ)
A3777_RS05665	COG1217	gtp-binding protein TYPA
A3777_RS05670	COG0483	inositol monophosphate 1-phosphatase activity
A3777_RS05675	COG4476	Belongs to the UPF0223 family
A3777_RS05680	COG0038	chloride channel
A3777_RS05700	COG0018	arginyl-trna synthetase
A3777_RS05705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A3777_RS05710	COG0456	acetyltransferase
A3777_RS05720	COG1214	PFAM Peptidase M22, glycoprotease
A3777_RS05775	COG4589	Belongs to the CDS family
A3777_RS05780	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3777_RS05785	COG1464	Belongs to the NlpA lipoprotein family
A3777_RS05790	COG2011	ABC-type metal ion transport system permease component
A3777_RS05795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A3777_RS05805	COG0509	glycine decarboxylation via glycine cleavage system
A3777_RS05810	COG1393	Belongs to the ArsC family
A3777_RS05815	COG0772	Belongs to the SEDS family
A3777_RS05845	COG1396	sequence-specific DNA binding
A3777_RS05875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A3777_RS05880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A3777_RS05885	COG0009	L-threonylcarbamoyladenylate synthase
A3777_RS05890	COG2890	protein-(glutamine-N5) methyltransferase activity
A3777_RS05895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A3777_RS05900	COG1435	thymidine kinase activity
A3777_RS05905	COG1053	succinate dehydrogenase
A3777_RS05910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3777_RS05920	COG0493	'glutamate synthase
A3777_RS05920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3777_RS05925	COG0543	2 iron, 2 sulfur cluster binding
A3777_RS05930	COG0716	FMN binding
A3777_RS05935	COG3608	succinylglutamate desuccinylase aspartoacylase
A3777_RS05935	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A3777_RS05940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A3777_RS05960	COG1104	cysteine desulfurase activity
A3777_RS05965	COG0746	molybdenum cofactor guanylyltransferase activity
A3777_RS05975	COG3608	succinylglutamate desuccinylase aspartoacylase
A3777_RS05975	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A3777_RS05990	COG0251	oxidation-reduction process
A3777_RS05995	COG0549	Belongs to the carbamate kinase family
A3777_RS06000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3777_RS06005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3777_RS06020	COG0493	'glutamate synthase
A3777_RS06020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3777_RS06025	COG0402	S-adenosylhomocysteine deaminase activity
A3777_RS06040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A3777_RS06045	COG3442	glutamine amidotransferase
A3777_RS06050	COG1957	nucleoside hydrolase
A3777_RS06060	COG1482	cell wall glycoprotein biosynthetic process
A3777_RS06075	COG1132	(ABC) transporter
A3777_RS06090	COG0194	GDP metabolic process
A3777_RS06095	COG2723	6-phospho-beta-galactosidase activity
A3777_RS06100	COG1263	PTS System
A3777_RS06100	COG2190	(PTS) system
A3777_RS06100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS06105	COG3711	transcriptional antiterminator
A3777_RS06110	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A3777_RS06115	COG0628	permease
A3777_RS06130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A3777_RS06135	COG4836	Membrane
A3777_RS06140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A3777_RS06145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A3777_RS06150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A3777_RS06155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A3777_RS06160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A3777_RS06165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A3777_RS06170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A3777_RS06175	COG0356	it plays a direct role in the translocation of protons across the membrane
A3777_RS06185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A3777_RS06190	COG0557	exoribonuclease II activity
A3777_RS06205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A3777_RS06210	COG2388	GCN5-related N-acetyl-transferase
A3777_RS06215	COG3592	Divergent 4Fe-4S mono-cluster
A3777_RS06220	COG2217	Heavy metal translocating P-type atpase
A3777_RS06225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A3777_RS06230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A3777_RS06235	COG2246	polysaccharide biosynthetic process
A3777_RS06240	COG3942	CHAP domain
A3777_RS06240	COG1705	Flagellar rod assembly protein muramidase FlgJ
A3777_RS06255	COG0459	protein refolding
A3777_RS06260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A3777_RS06275	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A3777_RS06280	COG0488	(ABC) transporter
A3777_RS06290	COG3448	diguanylate cyclase activity
A3777_RS06290	COG4175	Glycine betaine
A3777_RS06305	COG1597	lipid kinase activity
A3777_RS06310	COG3835	regulator
A3777_RS06315	COG1929	Belongs to the glycerate kinase type-1 family
A3777_RS06320	COG2610	gluconate transmembrane transporter activity
A3777_RS06325	COG0398	Pfam SNARE associated Golgi protein
A3777_RS06330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A3777_RS06335	COG1177	transmembrane transport
A3777_RS06340	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3777_RS06345	COG3842	ATPase activity
A3777_RS06355	COG0604	alcohol dehydrogenase
A3777_RS06365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A3777_RS06370	COG4684	Psort location CytoplasmicMembrane, score
A3777_RS06375	COG2348	transferase activity, transferring amino-acyl groups
A3777_RS06390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3777_RS06400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A3777_RS06410	COG3142	Participates in the control of copper homeostasis
A3777_RS06415	COG2239	Acts as a magnesium transporter
A3777_RS06420	COG0564	pseudouridine synthase activity
A3777_RS06425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3777_RS06430	COG2357	RelA SpoT domain protein
A3777_RS06435	COG4116	CYTH
A3777_RS06450	COG1164	Oligoendopeptidase f
A3777_RS06460	COG4862	establishment of competence for transformation
A3777_RS06465	COG1393	Belongs to the ArsC family
A3777_RS06470	COG0180	Tryptophanyl-tRNA synthetase
A3777_RS06475	COG1132	(ABC) transporter
A3777_RS06520	COG0419	ATPase involved in DNA repair
A3777_RS06525	COG0420	3'-5' exonuclease activity
A3777_RS06530	COG0204	Acyl-transferase
A3777_RS06535	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A3777_RS06540	COG2827	Endonuclease containing a URI domain
A3777_RS06545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A3777_RS06555	COG0494	nUDIX hydrolase
A3777_RS06565	COG3853	Toxic anion resistance protein (TelA)
A3777_RS06595	COG1194	a g-specific adenine glycosylase
A3777_RS06600	COG2137	regulation of response to DNA damage stimulus
A3777_RS06605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3777_RS06615	COG2261	transglycosylase associated protein
A3777_RS06620	COG3250	beta-galactosidase activity
A3777_RS06625	COG0531	amino acid
A3777_RS06630	COG2207	Transcriptional regulator
A3777_RS06630	COG1917	Cupin 2, conserved barrel domain protein
A3777_RS06635	COG0222	ribosome binding
A3777_RS06640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A3777_RS06645	COG0081	regulation of translation
A3777_RS06650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A3777_RS06655	COG0488	(ABC) transporter
A3777_RS06660	COG1760	l-serine dehydratase
A3777_RS06665	COG1760	l-serine dehydratase
A3777_RS06675	COG1363	Peptidase, m42
A3777_RS06680	COG4166	transmembrane transport
A3777_RS06695	COG0250	Participates in transcription elongation, termination and antitermination
A3777_RS06700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A3777_RS06705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A3777_RS06725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A3777_RS06735	COG0708	Exodeoxyribonuclease III
A3777_RS06770	COG0095	Lipoate-protein ligase
A3777_RS06775	COG1234	tRNA 3'-trailer cleavage
A3777_RS06785	COG1363	Peptidase, m42
A3777_RS06790	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A3777_RS06795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A3777_RS06800	COG1696	Membrane protein involved in D-alanine export
A3777_RS06805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A3777_RS06815	COG0577	efflux transmembrane transporter activity
A3777_RS06820	COG1136	(ABC) transporter
A3777_RS06825	COG1328	CTP reductase activity
A3777_RS06830	COG0602	queuosine metabolic process
A3777_RS06840	COG0390	transport system, permease component
A3777_RS06845	COG4619	ABC transporter
A3777_RS06855	COG4467	Involved in initiation control of chromosome replication
A3777_RS06860	COG1774	PSP1 C-terminal conserved region
A3777_RS06865	COG0470	DNA polymerase III
A3777_RS06870	COG3870	Protein conserved in bacteria
A3777_RS06875	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A3777_RS06885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A3777_RS06890	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A3777_RS06900	COG1122	ATPase activity
A3777_RS06915	COG0477	Major facilitator Superfamily
A3777_RS06920	COG2814	Major facilitator Superfamily
A3777_RS06925	COG1733	regulation of RNA biosynthetic process
A3777_RS06930	COG0351	phosphomethylpyrimidine kinase
A3777_RS06935	COG0352	thiamine-phosphate diphosphorylase activity
A3777_RS06940	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A3777_RS06950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A3777_RS06955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A3777_RS06960	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A3777_RS06965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3777_RS06980	COG3189	MarR family transcriptional regulator
A3777_RS06985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A3777_RS06990	COG1940	carbohydrate kinase activity
A3777_RS07005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A3777_RS07010	COG1073	alpha beta
A3777_RS07065	COG3942	CHAP domain
A3777_RS07065	COG1388	LysM domain
A3777_RS07170	COG1396	sequence-specific DNA binding
A3777_RS07195	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A3777_RS07200	COG0768	penicillin binding
A3777_RS07205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A3777_RS07210	COG1942	4-Oxalocrotonate Tautomerase
A3777_RS07240	COG0217	transcriptional regulatory protein
A3777_RS07245	COG1323	Belongs to the UPF0348 family
A3777_RS07250	COG2226	methyltransferase
A3777_RS07255	COG0799	negative regulation of ribosome biogenesis
A3777_RS07260	COG1713	HD superfamily hydrolase involved in NAD metabolism
A3777_RS07265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A3777_RS07270	COG1534	Rna-binding protein
A3777_RS07275	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A3777_RS07285	COG0825	malonyl-CoA metabolic process
A3777_RS07290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A3777_RS07295	COG0439	Biotin carboxylase
A3777_RS07300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A3777_RS07310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A3777_RS07320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A3777_RS07335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3777_RS07340	COG1846	Transcriptional regulator
A3777_RS07345	COG4703	Protein of unknown function (DUF1797)
A3777_RS07350	COG2084	Dehydrogenase
A3777_RS07355	COG0438	transferase activity, transferring glycosyl groups
A3777_RS07400	COG1098	S1 RNA binding domain
A3777_RS07405	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A3777_RS07420	COG0492	ferredoxin-NADP+ reductase activity
A3777_RS07435	COG0737	Belongs to the 5'-nucleotidase family
A3777_RS07455	COG1175	transmembrane transport
A3777_RS07460	COG3842	ATPase activity
A3777_RS07465	COG0463	Glycosyl transferase, family 2
A3777_RS07470	COG4841	protein insertion into membrane
A3777_RS07475	COG0569	domain protein
A3777_RS07480	COG2197	response regulator
A3777_RS07485	COG4585	Histidine kinase
A3777_RS07495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3777_RS07500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A3777_RS07510	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A3777_RS07515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A3777_RS07530	COG2832	Protein of unknown function (DUF454)
A3777_RS07535	COG5503	Protein of unknown function (DUF1447)
A3777_RS07545	COG1278	Cold shock
A3777_RS07550	COG2003	Belongs to the UPF0758 family
A3777_RS07555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3777_RS07560	COG0285	dihydrofolate synthase activity
A3777_RS07575	COG0525	valine-tRNA ligase activity
A3777_RS07580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A3777_RS07585	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A3777_RS07590	COG0301	tRNA thio-modification
A3777_RS07595	COG2252	PERMEase
A3777_RS07600	COG4221	oxidoreductase activity
A3777_RS07605	COG0110	maltose O-acetyltransferase activity
A3777_RS07610	COG0583	DNA-binding transcription factor activity
A3777_RS07615	COG4975	Glucose uptake
A3777_RS07620	COG1869	D-ribose catabolic process
A3777_RS07630	COG1609	Transcriptional regulator
A3777_RS07635	COG0657	acetylesterase activity
A3777_RS07650	COG3711	transcriptional antiterminator
A3777_RS07675	COG1834	amidinotransferase
A3777_RS07680	COG1785	Belongs to the alkaline phosphatase family
A3777_RS07685	COG1193	negative regulation of DNA recombination
A3777_RS07700	COG3716	PTS system mannose fructose sorbose family IID component
A3777_RS07705	COG3715	PTS system
A3777_RS07710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS07740	COG0577	efflux transmembrane transporter activity
A3777_RS07745	COG1136	(ABC) transporter
A3777_RS07750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3777_RS07760	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3777_RS07770	COG1937	Protein conserved in bacteria
A3777_RS07780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A3777_RS07785	COG2508	Transcriptional regulator
A3777_RS07790	COG3257	ureidoglycine aminohydrolase activity
A3777_RS07795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3777_RS07800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A3777_RS07805	COG1953	Uracil, thiamine, allantoin
A3777_RS07815	COG1846	Transcriptional regulator
A3777_RS07825	COG0659	secondary active sulfate transmembrane transporter activity
A3777_RS07830	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A3777_RS07835	COG2723	6-phospho-beta-galactosidase activity
A3777_RS07840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS07845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS07890	COG2508	Transcriptional regulator
A3777_RS07900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A3777_RS07905	COG1304	FMN binding
A3777_RS07920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A3777_RS07925	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A3777_RS07960	COG1823	symporter activity
A3777_RS07965	COG5492	domain, Protein
A3777_RS07975	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A3777_RS07980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3777_RS07985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3777_RS07995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A3777_RS08000	COG1363	Peptidase, m42
A3777_RS08015	COG4166	transmembrane transport
A3777_RS08020	COG3716	PTS system mannose fructose sorbose family IID component
A3777_RS08025	COG3715	PTS system
A3777_RS08030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A3777_RS08035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS08050	COG3394	polysaccharide catabolic process
A3777_RS08060	COG0519	Catalyzes the synthesis of GMP from XMP
A3777_RS08090	COG3764	Sortase (surface protein transpeptidase)
A3777_RS08100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3777_RS08130	COG1185	polyribonucleotide nucleotidyltransferase activity
A3777_RS08135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A3777_RS08140	COG0242	peptide deformylase activity
A3777_RS08160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A3777_RS08170	COG1268	BioY protein
A3777_RS08175	COG0681	Belongs to the peptidase S26 family
A3777_RS08195	COG4493	Belongs to the UPF0637 family
A3777_RS08205	COG2195	Cleaves the N-terminal amino acid of tripeptides
A3777_RS08210	COG4166	transmembrane transport
A3777_RS08215	COG4607	ABC-type enterochelin transport system periplasmic component
A3777_RS08220	COG4604	ABC transporter, ATP-binding protein
A3777_RS08225	COG4605	iron ion homeostasis
A3777_RS08230	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3777_RS08250	COG2918	glutathione biosynthetic process
A3777_RS08250	COG1181	Belongs to the D-alanine--D-alanine ligase family
A3777_RS08260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A3777_RS08275	COG0552	protein localization to endoplasmic reticulum
A3777_RS08280	COG0561	phosphatase activity
A3777_RS08285	COG1196	nuclear chromosome segregation
A3777_RS08290	COG0571	ribonuclease III activity
A3777_RS08305	COG0601	transmembrane transport
A3777_RS08310	COG4608	Belongs to the ABC transporter superfamily
A3777_RS08320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A3777_RS08325	COG0416	fatty acid biosynthetic process
A3777_RS08330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A3777_RS08335	COG1461	Dihydroxyacetone kinase
A3777_RS08345	COG3279	Response regulator of the LytR AlgR family
A3777_RS08360	COG1668	transmembrane transport
A3777_RS08365	COG4152	abc transporter atp-binding protein
A3777_RS08370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A3777_RS08380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A3777_RS08385	COG1162	GTPase activity
A3777_RS08390	COG2815	serine threonine protein kinase
A3777_RS08390	COG0515	serine threonine protein kinase
A3777_RS08400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3777_RS08400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3777_RS08405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A3777_RS08415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A3777_RS08420	COG1758	RNA polymerase activity
A3777_RS08425	COG0194	GDP metabolic process
A3777_RS08455	COG0800	Aldolase
A3777_RS08460	COG1312	Catalyzes the dehydration of D-mannonate
A3777_RS08470	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS08475	COG3716	PTS system mannose fructose sorbose family IID component
A3777_RS08485	COG0371	Dehydrogenase
A3777_RS08495	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A3777_RS08500	COG1737	Transcriptional regulator
A3777_RS08505	COG1132	(ABC) transporter
A3777_RS08515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3777_RS08525	COG1426	Protein conserved in bacteria
A3777_RS08530	COG0612	Peptidase, M16
A3777_RS08535	COG0612	Peptidase, M16
A3777_RS08540	COG1970	mechanosensitive ion channel activity
A3777_RS08555	COG2188	Transcriptional regulator
A3777_RS08560	COG1554	hydrolase, family 65, central catalytic
A3777_RS08565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3777_RS08575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A3777_RS08585	COG0424	maF-like protein
A3777_RS08590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A3777_RS08595	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A3777_RS08600	COG4550	Control of competence regulator ComK, YlbF/YmcA
A3777_RS08605	COG1692	metallophosphoesterase
A3777_RS08610	COG1418	mRNA catabolic process
A3777_RS08615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A3777_RS08620	COG1546	Belongs to the CinA family
A3777_RS08620	COG1058	Belongs to the CinA family
A3777_RS08625	COG2433	Pfam Transposase IS66
A3777_RS08630	COG2910	NAD(P)H-binding
A3777_RS08635	COG1959	2 iron, 2 sulfur cluster binding
A3777_RS08650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3777_RS08710	COG1335	isochorismatase
A3777_RS08715	COG1346	cytolysis
A3777_RS08725	COG3279	Response regulator of the LytR AlgR family
A3777_RS08730	COG3275	phosphorelay sensor kinase activity
A3777_RS08740	COG2011	ABC-type metal ion transport system permease component
A3777_RS08755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A3777_RS08760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A3777_RS08775	COG0803	Belongs to the bacterial solute-binding protein 9 family
A3777_RS08775	COG3443	Belongs to the bacterial solute-binding protein 9 family
A3777_RS08780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3777_RS08785	COG0842	Transport permease protein
A3777_RS08790	COG1131	(ABC) transporter
A3777_RS08805	COG3715	PTS system
A3777_RS08810	COG3716	PTS system mannose fructose sorbose family IID component
A3777_RS08825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A3777_RS08830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A3777_RS08835	COG0783	Belongs to the Dps family
A3777_RS08845	COG1070	Carbohydrate kinase
A3777_RS08850	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A3777_RS08855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3777_RS08860	COG0085	RNA polymerase activity
A3777_RS08890	COG3397	chitin binding
A3777_RS08900	COG1316	TRANSCRIPTIONal
A3777_RS08920	COG1575	Belongs to the MenA family. Type 1 subfamily
A3777_RS08930	COG4939	FMN-binding domain protein
A3777_RS08950	COG0142	geranyltranstransferase activity
A3777_RS08960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A3777_RS08965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A3777_RS08970	COG0302	gtp cyclohydrolase
A3777_RS08980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A3777_RS08985	COG1476	TRANSCRIPTIONal
A3777_RS08990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3777_RS09015	COG2508	Transcriptional regulator
A3777_RS09015	COG2508	Transcriptional regulator
A3777_RS09020	COG0826	peptidase U32
A3777_RS09025	COG0826	peptidase U32
A3777_RS09035	COG0542	response to heat
A3777_RS09040	COG4463	regulation of RNA biosynthetic process
A3777_RS09045	COG0626	cystathionine gamma-synthase activity
A3777_RS09050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS09055	COG1737	Transcriptional regulator
A3777_RS09125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3777_RS09130	COG0516	GMP reductase activity
A3777_RS09130	COG0517	IMP dehydrogenase activity
A3777_RS09145	COG0012	GTP binding
A3777_RS09150	COG4481	Protein conserved in bacteria
A3777_RS09155	COG1475	DNA binding
A3777_RS09160	COG1192	Involved in chromosome partitioning
A3777_RS09165	COG0357	Ribosomal RNA small subunit methyltransferase G
A3777_RS09190	COG3732	PTS system glucitol sorbitol-specific
A3777_RS09195	COG3730	PTS system glucitol sorbitol-specific
A3777_RS09215	COG0445	tRNA wobble uridine modification
A3777_RS09220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A3777_RS09235	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A3777_RS09265	COG3052	prosthetic group binding
A3777_RS09270	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A3777_RS09280	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A3777_RS09285	COG0511	ligase activity, forming carbon-carbon bonds
A3777_RS09295	COG2851	Citrate transporter
A3777_RS09305	COG0745	RESPONSE REGULATOR receiver
A3777_RS09315	COG0706	membrane insertase activity
A3777_RS09320	COG0594	ribonuclease P activity
A3777_RS09325	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A3777_RS09330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A3777_RS09335	COG0592	DNA-directed DNA polymerase activity
A3777_RS09340	COG2501	S4 domain
A3777_RS09345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A3777_RS09350	COG0187	DNA topoisomerase II activity
A3777_RS09360	COG0360	Binds together with S18 to 16S ribosomal RNA
A3777_RS09365	COG0629	single-stranded DNA binding
A3777_RS09370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A3777_RS09380	COG0359	binds to the 23S rRNA
A3777_RS09385	COG0305	Participates in initiation and elongation during chromosome replication
A3777_RS09390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A3777_RS09400	COG0488	(ABC) transporter
A3777_RS09405	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A3777_RS09405	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A3777_RS09410	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS09410	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS09420	COG3715	PTS system
A3777_RS09425	COG3716	PTS system mannose fructose sorbose family IID component
A3777_RS09445	COG1737	Transcriptional regulator
A3777_RS09455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A3777_RS09460	COG0251	oxidation-reduction process
A3777_RS09470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS09480	COG1486	melibiose metabolic process
A3777_RS09485	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A3777_RS09485	COG0392	lysyltransferase activity
A3777_RS09520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A3777_RS09525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A3777_RS09530	COG0756	dUTP diphosphatase activity
A3777_RS09540	COG4956	integral membrane protein (PIN domain superfamily)
A3777_RS09545	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A3777_RS09550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3777_RS09555	COG1045	serine acetyltransferase
A3777_RS09560	COG0215	cysteine-tRNA ligase activity
A3777_RS09565	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A3777_RS09570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A3777_RS09575	COG3688	RNA-binding protein containing a PIN domain
A3777_RS09585	COG4466	Protein conserved in bacteria
A3777_RS09590	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A3777_RS09595	COG0803	Belongs to the bacterial solute-binding protein 9 family
A3777_RS09595	COG3443	Belongs to the bacterial solute-binding protein 9 family
A3777_RS09600	COG1121	(ABC) transporter
A3777_RS09605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3777_RS09610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3777_RS09615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A3777_RS09625	COG4166	transmembrane transport
A3777_RS09630	COG4224	UPF0291 protein
A3777_RS09635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3777_RS09645	COG0632	four-way junction helicase activity
A3777_RS09650	COG2255	four-way junction helicase activity
A3777_RS09660	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A3777_RS09665	COG3408	Glycogen debranching enzyme
A3777_RS09665	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A3777_RS09675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3777_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
A3777_RS09710	COG2261	transglycosylase associated protein
A3777_RS09715	COG2814	Major facilitator Superfamily
A3777_RS09740	COG1597	lipid kinase activity
A3777_RS09760	COG2116	formate transmembrane transporter activity
A3777_RS09770	COG2964	Protein conserved in bacteria
A3777_RS09780	COG1760	l-serine dehydratase
A3777_RS09785	COG1760	l-serine dehydratase
A3777_RS09790	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3777_RS09805	COG1438	arginine binding
A3777_RS09810	COG2235	arginine
A3777_RS09815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3777_RS09820	COG0549	Belongs to the carbamate kinase family
A3777_RS09830	COG1288	antiporter activity
A3777_RS09840	COG0640	Transcriptional regulator
A3777_RS09845	COG0604	alcohol dehydrogenase
A3777_RS09855	COG0251	oxidation-reduction process
A3777_RS09865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3777_RS09895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3777_RS09895	COG0519	Catalyzes the synthesis of GMP from XMP
A3777_RS09900	COG1072	(Pantothenic acid kinase))
A3777_RS09910	COG2813	Specifically methylates the guanine in position
A3777_RS09915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A3777_RS09920	COG1609	Transcriptional regulator
A3777_RS09925	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A3777_RS09930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A3777_RS09935	COG0295	cytidine deaminase activity
A3777_RS09940	COG1744	ABC transporter substrate-binding protein PnrA-like
A3777_RS09945	COG1744	ABC transporter substrate-binding protein PnrA-like
A3777_RS09950	COG3845	ABC transporter
A3777_RS09955	COG4603	Belongs to the binding-protein-dependent transport system permease family
A3777_RS09960	COG1079	Belongs to the binding-protein-dependent transport system permease family
A3777_RS09970	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A3777_RS09985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3777_RS09990	COG1120	ATPase activity
A3777_RS09995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3777_RS10000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3777_RS10005	COG1979	alcohol dehydrogenase
A3777_RS10010	COG0588	phosphoglycerate mutase activity
A3777_RS10020	COG2801	Transposase and inactivated derivatives
A3777_RS10025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3777_RS10030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3777_RS10035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A3777_RS10040	COG0049	tRNA binding
A3777_RS10045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3777_RS10050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A3777_RS10060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A3777_RS10065	COG0051	transcription antitermination factor activity, RNA binding
A3777_RS10070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A3777_RS10075	COG0088	Forms part of the polypeptide exit tunnel
A3777_RS10080	COG0089	rRNA binding
A3777_RS10085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A3777_RS10090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A3777_RS10095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A3777_RS10100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A3777_RS10105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A3777_RS10110	COG0255	Belongs to the universal ribosomal protein uL29 family
A3777_RS10115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A3777_RS10120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A3777_RS10125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A3777_RS10130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A3777_RS10135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A3777_RS10140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A3777_RS10145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A3777_RS10150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A3777_RS10155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A3777_RS10160	COG1841	ribosomal large subunit assembly
A3777_RS10165	COG0200	Binds to the 23S rRNA
A3777_RS10170	COG0201	protein transport
A3777_RS10175	COG0563	adenylate kinase activity
A3777_RS10180	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A3777_RS10185	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A3777_RS10190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A3777_RS10195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A3777_RS10200	COG0202	RNA polymerase activity
A3777_RS10205	COG0203	ribosomal protein L17
A3777_RS10220	COG1473	amidohydrolase
A3777_RS10225	COG1122	ATPase activity
A3777_RS10230	COG1122	ATPase activity
A3777_RS10245	COG0393	Putative heavy-metal-binding
A3777_RS10250	COG1114	Component of the transport system for branched-chain amino acids
A3777_RS10270	COG1126	abc transporter atp-binding protein
A3777_RS10275	COG0765	amino acid transport
A3777_RS10285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3777_RS10290	COG0110	maltose O-acetyltransferase activity
A3777_RS10295	COG1827	regulation of RNA biosynthetic process
A3777_RS10300	COG3942	CHAP domain
A3777_RS10300	COG1705	Flagellar rod assembly protein muramidase FlgJ
A3777_RS10310	COG0039	L-malate dehydrogenase activity
A3777_RS10315	COG0193	aminoacyl-tRNA hydrolase activity
A3777_RS10320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A3777_RS10325	COG2244	polysaccharide biosynthetic process
A3777_RS10330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A3777_RS10345	COG1098	S1 RNA binding domain
A3777_RS10350	COG0037	tRNA processing
A3777_RS10355	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A3777_RS10360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3777_RS10365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A3777_RS10370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3777_RS10375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A3777_RS10520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS10520	COG2190	(PTS) system
A3777_RS10520	COG1263	PTS System
A3777_RS10525	COG2723	6-phospho-beta-galactosidase activity
A3777_RS10530	COG2723	6-phospho-beta-galactosidase activity
A3777_RS10540	COG0596	Alpha beta hydrolase
A3777_RS10545	COG2169	Transcriptional regulator
A3777_RS10550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3777_RS10555	COG0519	Catalyzes the synthesis of GMP from XMP
A3777_RS10560	COG1418	mRNA catabolic process
A3777_RS10575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A3777_RS10580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A3777_RS10585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A3777_RS10595	COG0167	dihydroorotate dehydrogenase activity
A3777_RS10605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A3777_RS10615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A3777_RS10620	COG0626	cystathionine gamma-synthase activity
A3777_RS10625	COG2723	6-phospho-beta-galactosidase activity
A3777_RS10630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS10640	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A3777_RS10645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3777_RS10660	COG2217	Heavy metal translocating P-type atpase
A3777_RS10675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3777_RS10680	COG3579	cysteine-type endopeptidase activity
A3777_RS10685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3777_RS10690	COG0346	lactoylglutathione lyase activity
A3777_RS10695	COG2076	Multidrug Resistance protein
A3777_RS10700	COG2076	Multidrug Resistance protein
A3777_RS10705	COG3469	chitinase activity
A3777_RS10710	COG3397	chitin binding
A3777_RS10720	COG1801	Protein of unknown function DUF72
A3777_RS10730	COG0527	aspartate kinase activity
A3777_RS10735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3777_RS10740	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A3777_RS10745	COG1104	cysteine desulfurase activity
A3777_RS10750	COG0745	RESPONSE REGULATOR receiver
A3777_RS10755	COG5002	protein histidine kinase activity
A3777_RS10800	COG3835	regulator
A3777_RS10805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A3777_RS10810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A3777_RS10825	COG0549	Belongs to the carbamate kinase family
A3777_RS10835	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A3777_RS10865	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A3777_RS10870	COG0628	permease
A3777_RS10895	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A3777_RS10900	COG1757	Na H antiporter
A3777_RS10905	COG1846	Transcriptional regulator
A3777_RS10910	COG0778	Nitroreductase
A3777_RS10915	COG0561	phosphatase activity
A3777_RS10925	COG3711	transcriptional antiterminator
A3777_RS10930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS10940	COG2213	PTS system mannitol-specific
A3777_RS10945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS10950	COG0246	Mannitol dehydrogenase
A3777_RS10955	COG2801	Transposase and inactivated derivatives
A3777_RS10965	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3777_RS10980	COG1136	(ABC) transporter
A3777_RS10980	COG0577	efflux transmembrane transporter activity
A3777_RS10985	COG0577	efflux transmembrane transporter activity
A3777_RS11005	COG2814	Major facilitator Superfamily
A3777_RS11015	COG1414	Transcriptional regulator
A3777_RS11020	COG0800	Aldolase
A3777_RS11030	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A3777_RS11035	COG1028	Short-chain dehydrogenase reductase Sdr
A3777_RS11040	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A3777_RS11065	COG1070	Carbohydrate kinase
A3777_RS11070	COG4806	L-rhamnose isomerase
A3777_RS11075	COG0235	Class ii aldolase
A3777_RS11080	COG3254	rhamnose metabolic process
A3777_RS11100	COG3104	oligopeptide transport
A3777_RS11110	COG3942	CHAP domain
A3777_RS11110	COG1388	LysM domain
A3777_RS11120	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A3777_RS11125	COG0318	PFAM AMP-dependent synthetase and ligase
A3777_RS11130	COG1169	isochorismate synthase
A3777_RS11135	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A3777_RS11140	COG2267	carboxylic ester hydrolase activity
A3777_RS11145	COG4948	Mandelate Racemase Muconate Lactonizing
A3777_RS11150	COG0363	glucosamine-6-phosphate deaminase activity
A3777_RS11155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A3777_RS11160	COG1764	response to oxidative stress
A3777_RS11175	COG3716	PTS system mannose fructose sorbose family IID component
A3777_RS11180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS11190	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A3777_RS11195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A3777_RS11210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A3777_RS11215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A3777_RS11220	COG1316	TRANSCRIPTIONal
A3777_RS11225	COG0363	glucosamine-6-phosphate deaminase activity
A3777_RS11230	COG1285	pathogenesis
A3777_RS11250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3777_RS11255	COG1780	Probably involved in ribonucleotide reductase function
A3777_RS11260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A3777_RS11280	COG0582	viral genome integration into host DNA
A3777_RS11305	COG3328	transposase activity
A3777_RS11315	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3777_RS11365	COG2801	Transposase and inactivated derivatives
A3777_RS11375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3777_RS11380	COG1335	isochorismatase
A3777_RS11410	COG3328	transposase activity
A3777_RS11440	COG2188	Transcriptional regulator
A3777_RS11450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS11455	COG1192	Involved in chromosome partitioning
A3777_RS11545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3777_RS11565	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A3777_RS11660	COG2207	Transcriptional regulator
A3777_RS11660	COG1917	Cupin 2, conserved barrel domain protein
A3777_RS11700	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A3777_RS11705	COG2190	(PTS) system
A3777_RS11705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS11705	COG1263	PTS System
A3777_RS11710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS11710	COG2190	(PTS) system
A3777_RS11710	COG1263	PTS System
A3777_RS11725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A3777_RS11770	COG0534	Mate efflux family protein
A3777_RS11775	COG0588	phosphoglycerate mutase activity
A3777_RS11800	COG4166	transmembrane transport
A3777_RS11815	COG0656	L-ascorbic acid biosynthetic process
A3777_RS11825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3777_RS11840	COG1113	amino acid transport
A3777_RS11845	COG1757	Na H antiporter
A3777_RS11860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A3777_RS11870	COG0039	L-malate dehydrogenase activity
A3777_RS11885	COG0583	DNA-binding transcription factor activity
A3777_RS11900	COG1733	regulation of RNA biosynthetic process
A3777_RS11905	COG0778	Nitroreductase
A3777_RS11910	COG0095	Lipoate-protein ligase
A3777_RS11930	COG1609	Transcriptional regulator
A3777_RS11940	COG2514	catechol 2,3-dioxygenase activity
A3777_RS11945	COG1349	DNA-binding transcription factor activity
A3777_RS11960	COG0534	Mate efflux family protein
A3777_RS11975	COG0217	transcriptional regulatory protein
A3777_RS11990	COG0346	lactoylglutathione lyase activity
A3777_RS12005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A3777_RS12010	COG2244	polysaccharide biosynthetic process
A3777_RS12015	COG1187	pseudouridine synthase activity
A3777_RS12030	COG3594	Acyltransferase
A3777_RS12035	COG1125	glycine betaine transport
A3777_RS12035	COG0517	IMP dehydrogenase activity
A3777_RS12040	COG1732	Glycine betaine
A3777_RS12045	COG1438	arginine binding
A3777_RS12050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3777_RS12055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3777_RS12060	COG0564	pseudouridine synthase activity
A3777_RS12065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3777_RS12070	COG3679	Belongs to the UPF0342 family
A3777_RS12085	COG3481	metal-dependent phosphohydrolase, HD sub domain
A3777_RS12090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A3777_RS12100	COG0537	adenosine 5'-monophosphoramidase activity
A3777_RS12105	COG1131	(ABC) transporter
A3777_RS12110	COG4473	ABC transporter
A3777_RS12115	COG0510	thiamine kinase activity
A3777_RS12120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3777_RS12135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS12135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3777_RS12135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3777_RS12145	COG3684	Belongs to the aldolase LacD family
A3777_RS12150	COG3557	Belongs to the UPF0374 family
A3777_RS12160	COG0628	permease
A3777_RS12165	COG1253	flavin adenine dinucleotide binding
A3777_RS12170	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A3777_RS12175	COG4974	Belongs to the 'phage' integrase family
A3777_RS12195	COG0582	viral genome integration into host DNA
A3777_RS12260	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A3777_RS12265	COG3421	Type III restriction
A3777_RS12295	COG0542	response to heat
A3777_RS12310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS12315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3777_RS12335	COG0544	peptidyl-prolyl cis-trans isomerase activity
A3777_RS12345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3777_RS12345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3777_RS12345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3777_RS12350	COG1105	Belongs to the carbohydrate kinase PfkB family
A3777_RS12355	COG1349	DNA-binding transcription factor activity
A3777_RS12365	COG0210	DNA helicase
A3777_RS12370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A3777_RS12380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3777_RS12385	COG0154	amidase activity
A3777_RS12390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3777_RS12395	COG1597	lipid kinase activity
A3777_RS12400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3777_RS12415	COG2197	response regulator
A3777_RS12420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3777_RS12425	COG0531	amino acid
A3777_RS12430	COG2957	Belongs to the agmatine deiminase family
A3777_RS12435	COG0549	Belongs to the carbamate kinase family
A3777_RS12440	COG0154	amidase activity
A3777_RS12455	COG1428	Deoxynucleoside kinase
A3777_RS12485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A3777_RS12495	COG1054	Belongs to the UPF0176 family
A3777_RS12540	COG2217	Heavy metal translocating P-type atpase
A3777_RS12545	COG1285	pathogenesis
A3777_RS12555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3777_RS12560	COG0556	nucleotide-excision repair
A3777_RS12565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A3777_RS12575	COG1660	Displays ATPase and GTPase activities
A3777_RS12580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A3777_RS12585	COG1481	regulation of sporulation
A3777_RS12600	COG0740	serine-type endopeptidase activity
A3777_RS12630	COG0584	glycerophosphoryl diester phosphodiesterase
A3777_RS12635	COG2816	NAD+ diphosphatase activity
A3777_RS12640	COG1278	Cold shock
A3777_RS12650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A3777_RS12655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3777_RS12655	COG2755	lipolytic protein G-D-S-L family
A3777_RS12660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A3777_RS12665	COG0477	Major facilitator Superfamily
A3777_RS12680	COG1132	(ABC) transporter
A3777_RS12685	COG1132	(ABC) transporter
A3777_RS12695	COG1309	transcriptional regulator
A3777_RS12700	COG0577	efflux transmembrane transporter activity
A3777_RS12705	COG1136	(ABC) transporter
A3777_RS12710	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A3777_RS12715	COG1242	4 iron, 4 sulfur cluster binding
A3777_RS12720	COG0671	phosphoesterase, PA-phosphatase related
A3777_RS12735	COG1705	Flagellar rod assembly protein muramidase FlgJ
A3777_RS12735	COG1388	LysM domain
A3777_RS12740	COG0495	leucyl-tRNA aminoacylation
A3777_RS12755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3777_RS12760	COG1126	abc transporter atp-binding protein
A3777_RS12765	COG0765	amino acid transport
A3777_RS12770	COG4166	transmembrane transport
A3777_RS12785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A3777_RS12790	COG1187	pseudouridine synthase activity
A3777_RS12795	COG1011	Hydrolase
A3777_RS12810	COG2337	Toxic component of a toxin-antitoxin (TA) module
A3777_RS12815	COG0673	inositol 2-dehydrogenase activity
A3777_RS12820	COG3711	transcriptional antiterminator
A3777_RS12850	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS12865	COG3964	amidohydrolase
A3777_RS12885	COG0187	DNA topoisomerase II activity
A3777_RS12890	COG1671	Belongs to the UPF0178 family
A3777_RS12895	COG1181	Belongs to the D-alanine--D-alanine ligase family
A3777_RS12900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A3777_RS12915	COG0736	holo-[acyl-carrier-protein] synthase activity
A3777_RS12920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A3777_RS12925	COG2337	Toxic component of a toxin-antitoxin (TA) module
A3777_RS12945	COG0681	Belongs to the peptidase S26 family
A3777_RS12955	COG2365	Tyrosine phosphatase family
A3777_RS12975	COG0531	amino acid
A3777_RS12985	COG1174	glycine betaine transport
A3777_RS13005	COG0346	lactoylglutathione lyase activity
A3777_RS13010	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A3777_RS13025	COG3158	transport of potassium into the cell
A3777_RS13035	COG2217	Heavy metal translocating P-type atpase
A3777_RS13045	COG4989	oxidoreductase activity
A3777_RS13050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3777_RS13050	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3777_RS13055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A3777_RS13060	COG0237	dephospho-CoA kinase activity
A3777_RS13065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A3777_RS13070	COG3611	Membrane attachment protein
A3777_RS13075	COG1484	DNA-dependent DNA replication
A3777_RS13095	COG1215	transferase activity, transferring glycosyl groups
A3777_RS13120	COG1126	abc transporter atp-binding protein
A3777_RS13125	COG0765	amino acid transport
A3777_RS13130	COG0371	Dehydrogenase
A3777_RS13135	COG0343	queuine tRNA-ribosyltransferase activity
A3777_RS13140	COG1862	Preprotein translocase
A3777_RS13155	COG1012	belongs to the aldehyde dehydrogenase family
A3777_RS13155	COG1454	alcohol dehydrogenase
A3777_RS13160	COG1304	FMN binding
A3777_RS13190	COG4166	transmembrane transport
A3777_RS13200	COG0601	transmembrane transport
A3777_RS13205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3777_RS13210	COG0444	Belongs to the ABC transporter superfamily
A3777_RS13215	COG4608	Belongs to the ABC transporter superfamily
A3777_RS13225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A3777_RS13230	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A3777_RS13235	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A3777_RS13245	COG3759	membrane
A3777_RS13255	COG0456	acetyltransferase
A3777_RS13255	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A3777_RS13260	COG0659	secondary active sulfate transmembrane transporter activity
A3777_RS13265	COG2855	membrane
A3777_RS13285	COG0745	RESPONSE REGULATOR receiver
A3777_RS13290	COG2205	protein histidine kinase activity
A3777_RS13295	COG4975	Glucose uptake
A3777_RS13300	COG0531	amino acid
A3777_RS13305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3777_RS13305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3777_RS13320	COG3973	AAA domain
A3777_RS13325	COG0084	hydrolase, TatD family'
A3777_RS13330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A3777_RS13335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3777_RS13345	COG3842	ATPase activity
A3777_RS13350	COG1803	Methylglyoxal synthase
A3777_RS13355	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A3777_RS13360	COG1132	(ABC) transporter
A3777_RS13375	COG3584	3D domain protein
A3777_RS13390	COG0561	phosphatase activity
A3777_RS13395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A3777_RS13400	COG0280	phosphate acetyltransferase
A3777_RS13405	COG0802	atpase or kinase
A3777_RS13420	COG1609	Transcriptional regulator
A3777_RS13425	COG2017	converts alpha-aldose to the beta-anomer
A3777_RS13430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3777_RS13440	COG2190	(PTS) system
A3777_RS13440	COG1263	PTS System
A3777_RS13440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A3777_RS13455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A3777_RS13460	COG4753	response regulator
A3777_RS13460	COG2207	Transcriptional regulator
A3777_RS13525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A3777_RS13535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A3777_RS13540	COG3223	Belongs to the PsiE family
A3777_RS13545	COG1408	metallophosphoesterase
A3777_RS13550	COG0006	proline dipeptidase activity
A3777_RS13555	COG1694	Mazg nucleotide pyrophosphohydrolase
A3777_RS13560	COG1302	Protein conserved in bacteria
A3777_RS13565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3777_RS13570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A3777_RS13575	COG1570	exodeoxyribonuclease VII activity
A3777_RS13580	COG1722	exodeoxyribonuclease VII activity
A3777_RS13585	COG0142	geranyltranstransferase activity
A3777_RS13590	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A3777_RS13605	COG1438	arginine binding
A3777_RS13610	COG0497	DNA recombination
A3777_RS13625	COG2001	Belongs to the MraZ family
A3777_RS13630	COG0275	rRNA processing
A3777_RS13640	COG0768	penicillin binding
A3777_RS13645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A3777_RS13650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A3777_RS13655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A3777_RS13660	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A3777_RS13665	COG0849	cell division
A3777_RS13670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3777_RS13675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A3777_RS13680	COG1799	cell septum assembly
A3777_RS13685	COG0762	integral membrane protein
A3777_RS13690	COG2302	S4 RNA-binding domain
A3777_RS13695	COG3599	regulation of cell shape
A3777_RS13700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A3777_RS13705	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A3777_RS13725	COG0673	inositol 2-dehydrogenase activity
A3777_RS13735	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A3777_RS13735	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A3777_RS13740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS13745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS13765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS13770	COG1447	Phosphotransferase system cellobiose-specific component IIA
A3777_RS13775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A3777_RS13780	COG2723	6-phospho-beta-galactosidase activity
A3777_RS13805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3777_RS13805	COG0574	Belongs to the PEP-utilizing enzyme family
A3777_RS13810	COG0517	IMP dehydrogenase activity
A3777_RS13815	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A3777_RS13820	COG0392	lysyltransferase activity
A3777_RS13820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A3777_RS13870	COG0105	UTP biosynthetic process
A3777_RS13885	COG0561	phosphatase activity
A3777_RS13895	COG2252	PERMEase
A3777_RS13900	COG2814	Major facilitator Superfamily