locus-tag	class	description
OG1RF_RS00015	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OG1RF_RS00020	COG0592	DNA-directed DNA polymerase activity
OG1RF_RS00025	COG2501	S4 domain
OG1RF_RS00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OG1RF_RS00035	COG0187	DNA topoisomerase II activity
OG1RF_RS00045	COG0360	Binds together with S18 to 16S ribosomal RNA
OG1RF_RS00050	COG0629	single-stranded DNA binding
OG1RF_RS00055	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OG1RF_RS00065	COG0359	binds to the 23S rRNA
OG1RF_RS00070	COG0305	Participates in initiation and elongation during chromosome replication
OG1RF_RS00075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OG1RF_RS00085	COG0488	(ABC) transporter
OG1RF_RS00090	COG3933	PFAM sigma-54 factor interaction domain-containing protein
OG1RF_RS00090	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OG1RF_RS00095	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS00095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS00105	COG3715	PTS system
OG1RF_RS00110	COG3716	PTS system mannose fructose sorbose family IID component
OG1RF_RS00130	COG1737	Transcriptional regulator
OG1RF_RS00135	COG1263	PTS System
OG1RF_RS00135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS00140	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OG1RF_RS00145	COG0251	oxidation-reduction process
OG1RF_RS00150	COG0392	lysyltransferase activity
OG1RF_RS00150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OG1RF_RS00185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OG1RF_RS00190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OG1RF_RS00195	COG0756	dUTP diphosphatase activity
OG1RF_RS00205	COG4956	integral membrane protein (PIN domain superfamily)
OG1RF_RS00210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OG1RF_RS00215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OG1RF_RS00220	COG1045	serine acetyltransferase
OG1RF_RS00225	COG0215	cysteine-tRNA ligase activity
OG1RF_RS00230	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
OG1RF_RS00235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OG1RF_RS00240	COG3688	RNA-binding protein containing a PIN domain
OG1RF_RS00250	COG4466	Protein conserved in bacteria
OG1RF_RS00255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OG1RF_RS00260	COG3443	Belongs to the bacterial solute-binding protein 9 family
OG1RF_RS00260	COG0803	Belongs to the bacterial solute-binding protein 9 family
OG1RF_RS00265	COG1121	(ABC) transporter
OG1RF_RS00270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OG1RF_RS00275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OG1RF_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OG1RF_RS00285	COG0737	Belongs to the 5'-nucleotidase family
OG1RF_RS00290	COG4166	transmembrane transport
OG1RF_RS00295	COG4224	UPF0291 protein
OG1RF_RS00300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
OG1RF_RS00305	COG0632	four-way junction helicase activity
OG1RF_RS00310	COG2255	four-way junction helicase activity
OG1RF_RS00320	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
OG1RF_RS00325	COG3408	Glycogen debranching enzyme
OG1RF_RS00325	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
OG1RF_RS00335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OG1RF_RS00345	COG1028	Short-chain dehydrogenase reductase Sdr
OG1RF_RS00370	COG2261	transglycosylase associated protein
OG1RF_RS00400	COG2814	Major facilitator Superfamily
OG1RF_RS00425	COG1597	lipid kinase activity
OG1RF_RS00445	COG2116	formate transmembrane transporter activity
OG1RF_RS00455	COG2964	Protein conserved in bacteria
OG1RF_RS00465	COG1760	l-serine dehydratase
OG1RF_RS00470	COG1760	l-serine dehydratase
OG1RF_RS00475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OG1RF_RS00490	COG1438	arginine binding
OG1RF_RS00495	COG2235	arginine
OG1RF_RS00500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OG1RF_RS00505	COG0549	Belongs to the carbamate kinase family
OG1RF_RS00515	COG1288	antiporter activity
OG1RF_RS00525	COG0640	Transcriptional regulator
OG1RF_RS00530	COG0604	alcohol dehydrogenase
OG1RF_RS00540	COG0251	oxidation-reduction process
OG1RF_RS00550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OG1RF_RS00580	COG0519	Catalyzes the synthesis of GMP from XMP
OG1RF_RS00580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OG1RF_RS00585	COG1072	(Pantothenic acid kinase))
OG1RF_RS00595	COG2813	Specifically methylates the guanine in position
OG1RF_RS00600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
OG1RF_RS00605	COG1609	Transcriptional regulator
OG1RF_RS00610	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
OG1RF_RS00615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
OG1RF_RS00620	COG0295	cytidine deaminase activity
OG1RF_RS00625	COG1744	ABC transporter substrate-binding protein PnrA-like
OG1RF_RS00630	COG1744	ABC transporter substrate-binding protein PnrA-like
OG1RF_RS00635	COG3845	ABC transporter
OG1RF_RS00640	COG4603	Belongs to the binding-protein-dependent transport system permease family
OG1RF_RS00645	COG1079	Belongs to the binding-protein-dependent transport system permease family
OG1RF_RS00670	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OG1RF_RS00685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OG1RF_RS00690	COG1120	ATPase activity
OG1RF_RS00695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OG1RF_RS00700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OG1RF_RS00705	COG1979	alcohol dehydrogenase
OG1RF_RS00710	COG0588	phosphoglycerate mutase activity
OG1RF_RS00715	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
OG1RF_RS00720	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
OG1RF_RS00725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OG1RF_RS00730	COG0049	tRNA binding
OG1RF_RS00735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OG1RF_RS00740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OG1RF_RS00745	COG0351	phosphomethylpyrimidine kinase
OG1RF_RS00750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OG1RF_RS00755	COG0051	transcription antitermination factor activity, RNA binding
OG1RF_RS00760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OG1RF_RS00765	COG0088	Forms part of the polypeptide exit tunnel
OG1RF_RS00770	COG0089	rRNA binding
OG1RF_RS00775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OG1RF_RS00780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OG1RF_RS00785	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OG1RF_RS00790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OG1RF_RS00795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OG1RF_RS00800	COG0255	Belongs to the universal ribosomal protein uL29 family
OG1RF_RS00805	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OG1RF_RS00810	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OG1RF_RS00815	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
OG1RF_RS00820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OG1RF_RS00825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OG1RF_RS00830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OG1RF_RS00835	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OG1RF_RS00840	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OG1RF_RS00845	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OG1RF_RS00850	COG1841	ribosomal large subunit assembly
OG1RF_RS00855	COG0200	Binds to the 23S rRNA
OG1RF_RS00860	COG0201	protein transport
OG1RF_RS00865	COG0563	adenylate kinase activity
OG1RF_RS00870	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
OG1RF_RS00875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OG1RF_RS00880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OG1RF_RS00885	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
OG1RF_RS00890	COG0202	RNA polymerase activity
OG1RF_RS00895	COG0203	ribosomal protein L17
OG1RF_RS00910	COG1473	amidohydrolase
OG1RF_RS00915	COG1122	ATPase activity
OG1RF_RS00920	COG1122	ATPase activity
OG1RF_RS00935	COG0393	Putative heavy-metal-binding
OG1RF_RS00940	COG1114	Component of the transport system for branched-chain amino acids
OG1RF_RS00955	COG1126	abc transporter atp-binding protein
OG1RF_RS00960	COG0765	amino acid transport
OG1RF_RS00970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
OG1RF_RS00975	COG0110	maltose O-acetyltransferase activity
OG1RF_RS00980	COG1827	regulation of RNA biosynthetic process
OG1RF_RS00985	COG1705	Flagellar rod assembly protein muramidase FlgJ
OG1RF_RS00985	COG3942	CHAP domain
OG1RF_RS00995	COG0039	L-malate dehydrogenase activity
OG1RF_RS01000	COG0193	aminoacyl-tRNA hydrolase activity
OG1RF_RS01005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OG1RF_RS01010	COG2244	polysaccharide biosynthetic process
OG1RF_RS01015	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
OG1RF_RS01030	COG1098	S1 RNA binding domain
OG1RF_RS01035	COG0037	tRNA processing
OG1RF_RS01040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
OG1RF_RS01045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OG1RF_RS01050	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OG1RF_RS01055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OG1RF_RS01060	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OG1RF_RS01205	COG3711	transcriptional antiterminator
OG1RF_RS01210	COG2190	(PTS) system
OG1RF_RS01210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS01210	COG1263	PTS System
OG1RF_RS01215	COG2723	6-phospho-beta-galactosidase activity
OG1RF_RS01220	COG2723	6-phospho-beta-galactosidase activity
OG1RF_RS01230	COG0596	Alpha beta hydrolase
OG1RF_RS01235	COG2169	Transcriptional regulator
OG1RF_RS01240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OG1RF_RS01245	COG0519	Catalyzes the synthesis of GMP from XMP
OG1RF_RS01250	COG1418	mRNA catabolic process
OG1RF_RS01265	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
OG1RF_RS01270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OG1RF_RS01275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OG1RF_RS01280	COG0167	dihydroorotate dehydrogenase activity
OG1RF_RS01295	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OG1RF_RS01305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OG1RF_RS01310	COG0626	cystathionine gamma-synthase activity
OG1RF_RS01315	COG2723	6-phospho-beta-galactosidase activity
OG1RF_RS01320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS01330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OG1RF_RS01335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OG1RF_RS01350	COG2217	Heavy metal translocating P-type atpase
OG1RF_RS01365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OG1RF_RS01370	COG3579	cysteine-type endopeptidase activity
OG1RF_RS01375	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
OG1RF_RS01380	COG0346	lactoylglutathione lyase activity
OG1RF_RS01385	COG2076	Multidrug Resistance protein
OG1RF_RS01390	COG2076	Multidrug Resistance protein
OG1RF_RS01395	COG3469	chitinase activity
OG1RF_RS01400	COG3397	chitin binding
OG1RF_RS01410	COG1801	Protein of unknown function DUF72
OG1RF_RS01420	COG0527	aspartate kinase activity
OG1RF_RS01425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OG1RF_RS01430	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
OG1RF_RS01435	COG1104	cysteine desulfurase activity
OG1RF_RS01440	COG0745	RESPONSE REGULATOR receiver
OG1RF_RS01445	COG5002	protein histidine kinase activity
OG1RF_RS01465	COG0666	response to abiotic stimulus
OG1RF_RS01490	COG3835	regulator
OG1RF_RS01495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OG1RF_RS01500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OG1RF_RS01515	COG0549	Belongs to the carbamate kinase family
OG1RF_RS01525	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
OG1RF_RS01555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OG1RF_RS01560	COG0628	permease
OG1RF_RS01585	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
OG1RF_RS01590	COG1757	Na H antiporter
OG1RF_RS01595	COG1846	Transcriptional regulator
OG1RF_RS01600	COG0778	Nitroreductase
OG1RF_RS01605	COG0561	phosphatase activity
OG1RF_RS01615	COG3711	transcriptional antiterminator
OG1RF_RS01620	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS01630	COG2213	PTS system mannitol-specific
OG1RF_RS01635	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS01640	COG0246	Mannitol dehydrogenase
OG1RF_RS01645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
OG1RF_RS01660	COG1136	(ABC) transporter
OG1RF_RS01660	COG0577	efflux transmembrane transporter activity
OG1RF_RS01665	COG0577	efflux transmembrane transporter activity
OG1RF_RS01685	COG2814	Major facilitator Superfamily
OG1RF_RS01695	COG1414	Transcriptional regulator
OG1RF_RS01700	COG0800	Aldolase
OG1RF_RS01710	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
OG1RF_RS01715	COG1028	Short-chain dehydrogenase reductase Sdr
OG1RF_RS01720	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
OG1RF_RS01745	COG1070	Carbohydrate kinase
OG1RF_RS01750	COG4806	L-rhamnose isomerase
OG1RF_RS01755	COG0235	Class ii aldolase
OG1RF_RS01760	COG3254	rhamnose metabolic process
OG1RF_RS01780	COG3104	oligopeptide transport
OG1RF_RS01790	COG1388	LysM domain
OG1RF_RS01790	COG3942	CHAP domain
OG1RF_RS01800	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OG1RF_RS01805	COG0318	PFAM AMP-dependent synthetase and ligase
OG1RF_RS01810	COG1169	isochorismate synthase
OG1RF_RS01815	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OG1RF_RS01820	COG2267	carboxylic ester hydrolase activity
OG1RF_RS01825	COG4948	Mandelate Racemase Muconate Lactonizing
OG1RF_RS01830	COG0363	glucosamine-6-phosphate deaminase activity
OG1RF_RS01835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OG1RF_RS01840	COG1764	response to oxidative stress
OG1RF_RS01855	COG3716	PTS system mannose fructose sorbose family IID component
OG1RF_RS01860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS01870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OG1RF_RS01875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OG1RF_RS01890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OG1RF_RS01895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OG1RF_RS01900	COG1316	TRANSCRIPTIONal
OG1RF_RS01905	COG0363	glucosamine-6-phosphate deaminase activity
OG1RF_RS01910	COG1285	pathogenesis
OG1RF_RS01930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OG1RF_RS01935	COG1780	Probably involved in ribonucleotide reductase function
OG1RF_RS01940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
OG1RF_RS01965	COG0656	L-ascorbic acid biosynthetic process
OG1RF_RS01975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
OG1RF_RS01990	COG1113	amino acid transport
OG1RF_RS01995	COG1757	Na H antiporter
OG1RF_RS02010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OG1RF_RS02020	COG0039	L-malate dehydrogenase activity
OG1RF_RS02035	COG0583	DNA-binding transcription factor activity
OG1RF_RS02050	COG1733	regulation of RNA biosynthetic process
OG1RF_RS02055	COG0778	Nitroreductase
OG1RF_RS02060	COG0095	Lipoate-protein ligase
OG1RF_RS02080	COG1609	Transcriptional regulator
OG1RF_RS02090	COG2514	catechol 2,3-dioxygenase activity
OG1RF_RS02095	COG1349	DNA-binding transcription factor activity
OG1RF_RS02110	COG0534	Mate efflux family protein
OG1RF_RS02125	COG0217	transcriptional regulatory protein
OG1RF_RS02140	COG0346	lactoylglutathione lyase activity
OG1RF_RS02150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OG1RF_RS02155	COG2244	polysaccharide biosynthetic process
OG1RF_RS02160	COG1187	pseudouridine synthase activity
OG1RF_RS02175	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
OG1RF_RS02180	COG1518	maintenance of DNA repeat elements
OG1RF_RS02185	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
OG1RF_RS02200	COG3594	Acyltransferase
OG1RF_RS02205	COG1125	glycine betaine transport
OG1RF_RS02205	COG0517	IMP dehydrogenase activity
OG1RF_RS02210	COG1732	Glycine betaine
OG1RF_RS02215	COG1438	arginine binding
OG1RF_RS02220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OG1RF_RS02230	COG0564	pseudouridine synthase activity
OG1RF_RS02235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OG1RF_RS02240	COG3679	Belongs to the UPF0342 family
OG1RF_RS02255	COG3481	metal-dependent phosphohydrolase, HD sub domain
OG1RF_RS02260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
OG1RF_RS02270	COG0537	adenosine 5'-monophosphoramidase activity
OG1RF_RS02275	COG1131	(ABC) transporter
OG1RF_RS02280	COG4473	ABC transporter
OG1RF_RS02285	COG0510	thiamine kinase activity
OG1RF_RS02290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OG1RF_RS02305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OG1RF_RS02305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS02305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OG1RF_RS02315	COG3684	Belongs to the aldolase LacD family
OG1RF_RS02320	COG3557	Belongs to the UPF0374 family
OG1RF_RS02330	COG0628	permease
OG1RF_RS02335	COG1253	flavin adenine dinucleotide binding
OG1RF_RS02340	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OG1RF_RS02365	COG0542	response to heat
OG1RF_RS02380	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS02385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OG1RF_RS02405	COG0544	peptidyl-prolyl cis-trans isomerase activity
OG1RF_RS02415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS02415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OG1RF_RS02415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OG1RF_RS02420	COG1105	Belongs to the carbohydrate kinase PfkB family
OG1RF_RS02425	COG1349	DNA-binding transcription factor activity
OG1RF_RS02435	COG0210	DNA helicase
OG1RF_RS02440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OG1RF_RS02450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OG1RF_RS02455	COG0154	amidase activity
OG1RF_RS02460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OG1RF_RS02465	COG1597	lipid kinase activity
OG1RF_RS02470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OG1RF_RS02485	COG2197	response regulator
OG1RF_RS02490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OG1RF_RS02495	COG0531	amino acid
OG1RF_RS02500	COG2957	Belongs to the agmatine deiminase family
OG1RF_RS02505	COG0549	Belongs to the carbamate kinase family
OG1RF_RS02510	COG0154	amidase activity
OG1RF_RS02525	COG1428	Deoxynucleoside kinase
OG1RF_RS02555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
OG1RF_RS02565	COG1054	Belongs to the UPF0176 family
OG1RF_RS02610	COG2217	Heavy metal translocating P-type atpase
OG1RF_RS02615	COG1285	pathogenesis
OG1RF_RS02625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OG1RF_RS02630	COG0556	nucleotide-excision repair
OG1RF_RS02635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OG1RF_RS02645	COG1660	Displays ATPase and GTPase activities
OG1RF_RS02655	COG1481	regulation of sporulation
OG1RF_RS02670	COG0740	serine-type endopeptidase activity
OG1RF_RS02700	COG0584	glycerophosphoryl diester phosphodiesterase
OG1RF_RS02705	COG2816	NAD+ diphosphatase activity
OG1RF_RS02710	COG1278	Cold shock
OG1RF_RS02720	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
OG1RF_RS02725	COG2755	lipolytic protein G-D-S-L family
OG1RF_RS02725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
OG1RF_RS02730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OG1RF_RS02735	COG0477	Major facilitator Superfamily
OG1RF_RS02750	COG1132	(ABC) transporter
OG1RF_RS02755	COG1132	(ABC) transporter
OG1RF_RS02765	COG1309	transcriptional regulator
OG1RF_RS02770	COG0577	efflux transmembrane transporter activity
OG1RF_RS02775	COG1136	(ABC) transporter
OG1RF_RS02780	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
OG1RF_RS02785	COG1242	4 iron, 4 sulfur cluster binding
OG1RF_RS02790	COG0671	phosphoesterase, PA-phosphatase related
OG1RF_RS02805	COG1388	LysM domain
OG1RF_RS02805	COG1705	Flagellar rod assembly protein muramidase FlgJ
OG1RF_RS02810	COG0495	leucyl-tRNA aminoacylation
OG1RF_RS02825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OG1RF_RS02830	COG1126	abc transporter atp-binding protein
OG1RF_RS02835	COG0765	amino acid transport
OG1RF_RS02840	COG4166	transmembrane transport
OG1RF_RS02860	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
OG1RF_RS02870	COG2188	Transcriptional regulator
OG1RF_RS02875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS02875	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS02900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
OG1RF_RS02905	COG1187	pseudouridine synthase activity
OG1RF_RS02910	COG1011	Hydrolase
OG1RF_RS02925	COG2337	Toxic component of a toxin-antitoxin (TA) module
OG1RF_RS02930	COG0673	inositol 2-dehydrogenase activity
OG1RF_RS02935	COG3711	transcriptional antiterminator
OG1RF_RS02965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS02980	COG3964	amidohydrolase
OG1RF_RS03000	COG0187	DNA topoisomerase II activity
OG1RF_RS03005	COG1671	Belongs to the UPF0178 family
OG1RF_RS03010	COG1181	Belongs to the D-alanine--D-alanine ligase family
OG1RF_RS03015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OG1RF_RS03030	COG0736	holo-[acyl-carrier-protein] synthase activity
OG1RF_RS03035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OG1RF_RS03040	COG2337	Toxic component of a toxin-antitoxin (TA) module
OG1RF_RS03060	COG0681	Belongs to the peptidase S26 family
OG1RF_RS03070	COG2365	Tyrosine phosphatase family
OG1RF_RS03090	COG0531	amino acid
OG1RF_RS03100	COG1174	glycine betaine transport
OG1RF_RS03120	COG0346	lactoylglutathione lyase activity
OG1RF_RS03125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
OG1RF_RS03140	COG3158	transport of potassium into the cell
OG1RF_RS03150	COG2217	Heavy metal translocating P-type atpase
OG1RF_RS03160	COG4989	oxidoreductase activity
OG1RF_RS03165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OG1RF_RS03165	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OG1RF_RS03170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
OG1RF_RS03175	COG0237	dephospho-CoA kinase activity
OG1RF_RS03180	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OG1RF_RS03185	COG3611	Membrane attachment protein
OG1RF_RS03190	COG1484	DNA-dependent DNA replication
OG1RF_RS03210	COG1215	transferase activity, transferring glycosyl groups
OG1RF_RS03235	COG1126	abc transporter atp-binding protein
OG1RF_RS03240	COG0765	amino acid transport
OG1RF_RS03245	COG0371	Dehydrogenase
OG1RF_RS03250	COG0343	queuine tRNA-ribosyltransferase activity
OG1RF_RS03255	COG1862	Preprotein translocase
OG1RF_RS03265	COG1454	alcohol dehydrogenase
OG1RF_RS03265	COG1012	belongs to the aldehyde dehydrogenase family
OG1RF_RS03270	COG1304	FMN binding
OG1RF_RS03300	COG4166	transmembrane transport
OG1RF_RS03310	COG0601	transmembrane transport
OG1RF_RS03315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OG1RF_RS03320	COG0444	Belongs to the ABC transporter superfamily
OG1RF_RS03325	COG4608	Belongs to the ABC transporter superfamily
OG1RF_RS03335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OG1RF_RS03340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OG1RF_RS03345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OG1RF_RS03355	COG3759	membrane
OG1RF_RS03365	COG0456	acetyltransferase
OG1RF_RS03365	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
OG1RF_RS03370	COG0659	secondary active sulfate transmembrane transporter activity
OG1RF_RS03375	COG2855	membrane
OG1RF_RS03395	COG0745	RESPONSE REGULATOR receiver
OG1RF_RS03400	COG2205	protein histidine kinase activity
OG1RF_RS03405	COG4975	Glucose uptake
OG1RF_RS03410	COG0531	amino acid
OG1RF_RS03415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OG1RF_RS03415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OG1RF_RS03430	COG3973	AAA domain
OG1RF_RS03435	COG0084	hydrolase, TatD family'
OG1RF_RS03440	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
OG1RF_RS03445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OG1RF_RS03455	COG3842	ATPase activity
OG1RF_RS03460	COG1803	Methylglyoxal synthase
OG1RF_RS03465	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
OG1RF_RS03470	COG1132	(ABC) transporter
OG1RF_RS03485	COG3584	3D domain protein
OG1RF_RS03500	COG0561	phosphatase activity
OG1RF_RS03505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
OG1RF_RS03510	COG0280	phosphate acetyltransferase
OG1RF_RS03515	COG0802	atpase or kinase
OG1RF_RS03520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
OG1RF_RS03530	COG1609	Transcriptional regulator
OG1RF_RS03535	COG2017	converts alpha-aldose to the beta-anomer
OG1RF_RS03540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OG1RF_RS03550	COG2190	(PTS) system
OG1RF_RS03550	COG1263	PTS System
OG1RF_RS03550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS03560	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OG1RF_RS03640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OG1RF_RS03645	COG2868	ribosomal protein
OG1RF_RS03650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OG1RF_RS03655	COG3223	Belongs to the PsiE family
OG1RF_RS03660	COG1408	metallophosphoesterase
OG1RF_RS03665	COG0006	proline dipeptidase activity
OG1RF_RS03670	COG1694	Mazg nucleotide pyrophosphohydrolase
OG1RF_RS03675	COG1302	Protein conserved in bacteria
OG1RF_RS03680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OG1RF_RS03685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OG1RF_RS03690	COG1570	exodeoxyribonuclease VII activity
OG1RF_RS03695	COG1722	exodeoxyribonuclease VII activity
OG1RF_RS03700	COG0142	geranyltranstransferase activity
OG1RF_RS03705	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
OG1RF_RS03710	COG1438	arginine binding
OG1RF_RS03715	COG0497	DNA recombination
OG1RF_RS03735	COG2001	Belongs to the MraZ family
OG1RF_RS03740	COG0275	rRNA processing
OG1RF_RS03750	COG0768	penicillin binding
OG1RF_RS03755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OG1RF_RS03760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OG1RF_RS03765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OG1RF_RS03770	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
OG1RF_RS03775	COG0849	cell division
OG1RF_RS03780	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OG1RF_RS03785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
OG1RF_RS03790	COG1799	cell septum assembly
OG1RF_RS03795	COG0762	integral membrane protein
OG1RF_RS03800	COG2302	S4 RNA-binding domain
OG1RF_RS03805	COG3599	regulation of cell shape
OG1RF_RS03810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OG1RF_RS03815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
OG1RF_RS03835	COG0673	inositol 2-dehydrogenase activity
OG1RF_RS03845	COG3933	PFAM sigma-54 factor interaction domain-containing protein
OG1RF_RS03845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
OG1RF_RS03850	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS03855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS03875	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS03880	COG1447	Phosphotransferase system cellobiose-specific component IIA
OG1RF_RS03885	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS03890	COG2723	6-phospho-beta-galactosidase activity
OG1RF_RS03915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OG1RF_RS03915	COG0574	Belongs to the PEP-utilizing enzyme family
OG1RF_RS03920	COG0517	IMP dehydrogenase activity
OG1RF_RS03925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OG1RF_RS03930	COG0392	lysyltransferase activity
OG1RF_RS03930	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
OG1RF_RS03975	COG0105	UTP biosynthetic process
OG1RF_RS03990	COG0561	phosphatase activity
OG1RF_RS04000	COG2252	PERMEase
OG1RF_RS04005	COG2814	Major facilitator Superfamily
OG1RF_RS04015	COG0587	DNA-directed DNA polymerase activity
OG1RF_RS04020	COG0205	6-phosphofructokinase activity
OG1RF_RS04035	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OG1RF_RS04040	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
OG1RF_RS04045	COG0745	RESPONSE REGULATOR receiver
OG1RF_RS04050	COG5002	protein histidine kinase activity
OG1RF_RS04155	COG1674	ftsk spoiiie
OG1RF_RS04170	COG2946	Replication initiation factor
OG1RF_RS04215	COG0741	lytic transglycosylase activity
OG1RF_RS04215	COG0791	NLP P60 protein
OG1RF_RS04370	COG4974	Belongs to the 'phage' integrase family
OG1RF_RS04380	COG1116	anion transmembrane transporter activity
OG1RF_RS04385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OG1RF_RS04390	COG1660	Displays ATPase and GTPase activities
OG1RF_RS04395	COG1914	H( )-stimulated, divalent metal cation uptake system
OG1RF_RS04405	COG2508	Transcriptional regulator
OG1RF_RS04410	COG4166	transmembrane transport
OG1RF_RS04415	COG0402	S-adenosylhomocysteine deaminase activity
OG1RF_RS04420	COG0402	S-adenosylhomocysteine deaminase activity
OG1RF_RS04425	COG1956	GAF domain-containing protein
OG1RF_RS04435	COG0110	maltose O-acetyltransferase activity
OG1RF_RS04450	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
OG1RF_RS04455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OG1RF_RS04460	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
OG1RF_RS04465	COG1609	Transcriptional regulator
OG1RF_RS04470	COG0572	uridine kinase
OG1RF_RS04495	COG2814	Major facilitator Superfamily
OG1RF_RS04500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OG1RF_RS04530	COG0456	acetyltransferase
OG1RF_RS04600	COG1132	(ABC) transporter
OG1RF_RS04615	COG1113	amino acid transport
OG1RF_RS04635	COG0247	lactate metabolic process
OG1RF_RS04640	COG1139	Iron-sulfur cluster binding protein
OG1RF_RS04655	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
OG1RF_RS04660	COG1074	ATP-dependent DNA helicase activity
OG1RF_RS04665	COG1733	regulation of RNA biosynthetic process
OG1RF_RS04670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OG1RF_RS04675	COG0072	phenylalanine-tRNA ligase activity
OG1RF_RS04675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OG1RF_RS04680	COG0765	amino acid transport
OG1RF_RS04685	COG0765	amino acid transport
OG1RF_RS04690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OG1RF_RS04700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OG1RF_RS04705	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OG1RF_RS04710	COG0622	Phosphoesterase
OG1RF_RS04715	COG1349	DNA-binding transcription factor activity
OG1RF_RS04725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS04730	COG3037	sugar-specific permease SgaT UlaA
OG1RF_RS04740	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
OG1RF_RS04745	COG3623	hexulose-6-phosphate isomerase
OG1RF_RS04755	COG0517	IMP dehydrogenase activity
OG1RF_RS04760	COG2171	N-acyltransferase activity
OG1RF_RS04765	COG1473	amidohydrolase
OG1RF_RS04770	COG0668	transmembrane transport
OG1RF_RS04780	COG0656	L-ascorbic acid biosynthetic process
OG1RF_RS04785	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OG1RF_RS04805	COG1078	dGTPase activity
OG1RF_RS04810	COG0095	Lipoate-protein ligase
OG1RF_RS04825	COG0504	CTP synthase activity
OG1RF_RS04830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
OG1RF_RS04835	COG3331	DNA recombination
OG1RF_RS04840	COG4474	Belongs to the UPF0398 family
OG1RF_RS04845	COG3599	regulation of cell shape
OG1RF_RS04850	COG0116	Belongs to the methyltransferase superfamily
OG1RF_RS04855	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
OG1RF_RS04860	COG3935	DnaD domain protein
OG1RF_RS04865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OG1RF_RS04870	COG2188	Transcriptional regulator
OG1RF_RS04880	COG1446	asparaginase
OG1RF_RS04885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS04890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS04915	COG1666	GTP binding
OG1RF_RS04920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OG1RF_RS04925	COG0191	fructose-bisphosphate aldolase activity
OG1RF_RS04935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OG1RF_RS04940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
OG1RF_RS04945	COG0254	rRNA binding
OG1RF_RS04960	COG1940	carbohydrate kinase activity
OG1RF_RS04965	COG3237	CsbD-like
OG1RF_RS04970	COG0778	Nitroreductase
OG1RF_RS04975	COG1854	S-ribosylhomocysteine lyase activity
OG1RF_RS04980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OG1RF_RS04985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OG1RF_RS04995	COG0737	Belongs to the 5'-nucleotidase family
OG1RF_RS05000	COG4470	Protein conserved in bacteria
OG1RF_RS05005	COG0647	UMP catabolic process
OG1RF_RS05020	COG1307	EDD domain protein, DegV family
OG1RF_RS05025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OG1RF_RS05030	COG0745	RESPONSE REGULATOR receiver
OG1RF_RS05035	COG5002	protein histidine kinase activity
OG1RF_RS05050	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OG1RF_RS05055	COG0701	Predicted permease
OG1RF_RS05060	COG3689	TIGRFAM TIGR03943 family protein
OG1RF_RS05075	COG4472	Bacterial protein of unknown function (DUF965)
OG1RF_RS05080	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OG1RF_RS05085	COG3906	Belongs to the UPF0473 family
OG1RF_RS05100	COG3493	citrate carrier protein
OG1RF_RS05105	COG3290	protein histidine kinase activity
OG1RF_RS05110	COG4565	transcriptional regulatory protein
OG1RF_RS05115	COG0446	pyridine nucleotide-disulphide oxidoreductase
OG1RF_RS05120	COG1316	TRANSCRIPTIONal
OG1RF_RS05125	COG0028	Belongs to the TPP enzyme family
OG1RF_RS05130	COG3527	Alpha-acetolactate decarboxylase
OG1RF_RS05150	COG1175	transmembrane transport
OG1RF_RS05160	COG3842	ATPase activity
OG1RF_RS05170	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OG1RF_RS05175	COG0402	S-adenosylhomocysteine deaminase activity
OG1RF_RS05195	COG1053	succinate dehydrogenase
OG1RF_RS05195	COG3976	FMN-binding domain protein
OG1RF_RS05195	COG0431	NADPH-dependent FMN reductase
OG1RF_RS05215	COG1408	metallophosphoesterase
OG1RF_RS05220	COG4209	transmembrane transport
OG1RF_RS05225	COG0395	ABC-type sugar transport system, permease component
OG1RF_RS05240	COG3458	cephalosporin-C deacetylase activity
OG1RF_RS05255	COG3459	Glycosyltransferase 36 associated
OG1RF_RS05260	COG1609	Transcriptional regulator
OG1RF_RS05270	COG2188	Transcriptional regulator
OG1RF_RS05275	COG2723	6-phospho-beta-galactosidase activity
OG1RF_RS05280	COG0673	inositol 2-dehydrogenase activity
OG1RF_RS05285	COG2707	UPF0756 membrane protein
OG1RF_RS05300	COG1293	RNA-binding protein homologous to eukaryotic snRNP
OG1RF_RS05325	COG1122	ATPase activity
OG1RF_RS05345	COG0561	phosphatase activity
OG1RF_RS05350	COG0745	RESPONSE REGULATOR receiver
OG1RF_RS05355	COG3850	Histidine kinase
OG1RF_RS05355	COG5002	protein histidine kinase activity
OG1RF_RS05370	COG1368	sulfuric ester hydrolase activity
OG1RF_RS05375	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
OG1RF_RS05380	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OG1RF_RS05385	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OG1RF_RS05390	COG1388	LysM domain
OG1RF_RS05390	COG4932	domain protein
OG1RF_RS05395	COG0779	Required for maturation of 30S ribosomal subunits
OG1RF_RS05400	COG0195	Participates in both transcription termination and antitermination
OG1RF_RS05405	COG2740	Nucleic-acid-binding protein implicated in transcription termination
OG1RF_RS05415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OG1RF_RS05420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OG1RF_RS05510	COG4824	toxin secretion phage lysis holin
OG1RF_RS05520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
OG1RF_RS05525	COG0196	riboflavin kinase activity
OG1RF_RS05535	COG1695	Transcriptional regulator
OG1RF_RS05555	COG0772	Belongs to the SEDS family
OG1RF_RS05560	COG0583	DNA-binding transcription factor activity
OG1RF_RS05565	COG0583	DNA-binding transcription factor activity
OG1RF_RS05570	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OG1RF_RS05575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OG1RF_RS05580	COG1420	regulation of RNA biosynthetic process
OG1RF_RS05585	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OG1RF_RS05590	COG0443	Heat shock 70 kDa protein
OG1RF_RS05600	COG0484	heat shock protein binding
OG1RF_RS05610	COG2183	response to ionizing radiation
OG1RF_RS05615	COG3091	SprT-like family
OG1RF_RS05625	COG0436	Aminotransferase
OG1RF_RS05670	COG2268	Band 7 protein
OG1RF_RS05695	COG1309	transcriptional regulator
OG1RF_RS05705	COG2188	Transcriptional regulator
OG1RF_RS05710	COG4842	Belongs to the WXG100 family
OG1RF_RS05730	COG4499	WXG100 protein secretion system (Wss), protein YukC
OG1RF_RS05735	COG1674	ftsk spoiiie
OG1RF_RS05785	COG1674	ftsk spoiiie
OG1RF_RS05850	COG0492	ferredoxin-NADP+ reductase activity
OG1RF_RS05865	COG1136	(ABC) transporter
OG1RF_RS05865	COG0577	efflux transmembrane transporter activity
OG1RF_RS05865	COG1136	(ABC) transporter
OG1RF_RS05865	COG0577	efflux transmembrane transporter activity
OG1RF_RS05875	COG3833	ABC-type maltose transport systems, permease component
OG1RF_RS05880	COG1175	transmembrane transport
OG1RF_RS05885	COG2182	Extracellular solute-binding protein
OG1RF_RS05895	COG0366	Alpha amylase catalytic
OG1RF_RS05900	COG0366	Alpha amylase catalytic
OG1RF_RS05905	COG0366	Alpha amylase catalytic
OG1RF_RS05915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OG1RF_RS05945	COG0371	Dehydrogenase
OG1RF_RS05950	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
OG1RF_RS05955	COG2376	Dihydroxyacetone kinase
OG1RF_RS05960	COG1461	Dihydroxyacetone kinase
OG1RF_RS05970	COG3425	synthase
OG1RF_RS05985	COG0628	permease
OG1RF_RS05995	COG1278	Cold shock
OG1RF_RS06010	COG2814	Major facilitator Superfamily
OG1RF_RS06015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
OG1RF_RS06020	COG4109	DRTGG domain
OG1RF_RS06025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
OG1RF_RS06030	COG2824	Alkylphosphonate utilization operon protein PhnA
OG1RF_RS06045	COG0513	Belongs to the DEAD box helicase family
OG1RF_RS06055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OG1RF_RS06060	COG2384	SAM-dependent methyltransferase
OG1RF_RS06065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OG1RF_RS06070	COG2195	Cleaves the N-terminal amino acid of tripeptides
OG1RF_RS06085	COG0746	molybdenum cofactor guanylyltransferase activity
OG1RF_RS06090	COG2116	formate transmembrane transporter activity
OG1RF_RS06105	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
OG1RF_RS06110	COG3383	formate dehydrogenase (NAD+) activity
OG1RF_RS06115	COG0303	'Molybdopterin
OG1RF_RS06120	COG0315	cyclic pyranopterin monophosphate synthase activity
OG1RF_RS06135	COG0521	Mo-molybdopterin cofactor biosynthetic process
OG1RF_RS06145	COG0725	ABC transporter, periplasmic molybdate-binding protein
OG1RF_RS06150	COG4149	molybdate abc transporter
OG1RF_RS06155	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OG1RF_RS06160	COG2217	Heavy metal translocating P-type atpase
OG1RF_RS06175	COG1286	toxin biosynthetic process
OG1RF_RS06180	COG1193	negative regulation of DNA recombination
OG1RF_RS06185	COG3118	belongs to the thioredoxin family
OG1RF_RS06190	COG0322	excinuclease ABC activity
OG1RF_RS06200	COG4152	abc transporter atp-binding protein
OG1RF_RS06205	COG1668	transmembrane transport
OG1RF_RS06210	COG1609	Transcriptional regulator
OG1RF_RS06215	COG1486	melibiose metabolic process
OG1RF_RS06230	COG2081	HI0933 family
OG1RF_RS06235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OG1RF_RS06240	COG0166	Belongs to the GPI family
OG1RF_RS06260	COG1269	ATP hydrolysis coupled proton transport
OG1RF_RS06265	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OG1RF_RS06270	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
OG1RF_RS06275	COG1527	subunit (C
OG1RF_RS06280	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
OG1RF_RS06285	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
OG1RF_RS06290	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
OG1RF_RS06295	COG1394	ATPase activity, coupled to movement of substances
OG1RF_RS06305	COG1595	DNA-templated transcription, initiation
OG1RF_RS06320	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
OG1RF_RS06325	COG0019	diaminopimelate decarboxylase activity
OG1RF_RS06350	COG2151	metal-sulfur cluster biosynthetic enzyme
OG1RF_RS06355	COG4948	Mandelate Racemase Muconate Lactonizing
OG1RF_RS06365	COG4166	transmembrane transport
OG1RF_RS06370	COG3711	transcriptional antiterminator
OG1RF_RS06380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS06380	COG3711	transcriptional antiterminator
OG1RF_RS06390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OG1RF_RS06390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS06390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OG1RF_RS06395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS06405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OG1RF_RS06415	COG0741	lytic transglycosylase activity
OG1RF_RS06420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OG1RF_RS06425	COG0358	DNA primase activity
OG1RF_RS06430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OG1RF_RS06440	COG2996	Protein conserved in bacteria
OG1RF_RS06445	COG0735	belongs to the Fur family
OG1RF_RS06455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OG1RF_RS06465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS06485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OG1RF_RS06500	COG4974	Belongs to the 'phage' integrase family
OG1RF_RS06505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OG1RF_RS06510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OG1RF_RS06515	COG1187	pseudouridine synthase activity
OG1RF_RS06520	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
OG1RF_RS06540	COG0514	ATP-dependent DNA helicase (RecQ)
OG1RF_RS06550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
OG1RF_RS06555	COG0539	negative regulation of cytoplasmic translation
OG1RF_RS06560	COG1160	GTP binding
OG1RF_RS06575	COG0457	Tetratricopeptide repeat
OG1RF_RS06580	COG5582	Belongs to the UPF0302 family
OG1RF_RS06585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OG1RF_RS06590	COG1694	Mazg nucleotide pyrophosphohydrolase
OG1RF_RS06595	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OG1RF_RS06600	COG0617	tRNA 3'-terminal CCA addition
OG1RF_RS06615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
OG1RF_RS06620	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
OG1RF_RS06630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OG1RF_RS06635	COG0287	Prephenate dehydrogenase
OG1RF_RS06645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OG1RF_RS06650	COG0077	Prephenate dehydratase
OG1RF_RS06660	COG1307	EDD domain protein, DegV family
OG1RF_RS06685	COG0488	(ABC) transporter
OG1RF_RS06690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OG1RF_RS06700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OG1RF_RS06705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OG1RF_RS06710	COG4224	UPF0291 protein
OG1RF_RS06720	COG2814	Major facilitator Superfamily
OG1RF_RS06725	COG1705	Flagellar rod assembly protein muramidase FlgJ
OG1RF_RS06725	COG1388	LysM domain
OG1RF_RS06735	COG0735	belongs to the Fur family
OG1RF_RS06740	COG0446	pyridine nucleotide-disulphide oxidoreductase
OG1RF_RS06745	COG2816	NAD+ diphosphatase activity
OG1RF_RS06760	COG2207	Transcriptional regulator
OG1RF_RS06765	COG1132	(ABC) transporter
OG1RF_RS06770	COG1132	(ABC) transporter
OG1RF_RS06790	COG0753	catalase activity
OG1RF_RS06795	COG0415	Belongs to the DNA photolyase family
OG1RF_RS06805	COG2190	(PTS) system
OG1RF_RS06805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS06805	COG1263	PTS System
OG1RF_RS06810	COG0366	Alpha amylase catalytic
OG1RF_RS06820	COG1609	Transcriptional regulator
OG1RF_RS06830	COG2723	6-phospho-beta-galactosidase activity
OG1RF_RS06835	COG1263	PTS System
OG1RF_RS06835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS06835	COG2190	(PTS) system
OG1RF_RS06845	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
OG1RF_RS06855	COG1227	inorganic diphosphatase activity
OG1RF_RS06860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OG1RF_RS06865	COG1882	Formate acetyltransferase
OG1RF_RS06870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OG1RF_RS06875	COG0187	DNA topoisomerase II activity
OG1RF_RS06880	COG1832	CoA-binding protein
OG1RF_RS06885	COG4766	ethanolamine catabolic process
OG1RF_RS06890	COG3192	ethanolamine utilization protein
OG1RF_RS06895	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
OG1RF_RS06905	COG4869	propanediol catabolic process
OG1RF_RS06920	COG1012	belongs to the aldehyde dehydrogenase family
OG1RF_RS06920	COG1454	alcohol dehydrogenase
OG1RF_RS06935	COG4302	ethanolamine ammonia-lyase activity
OG1RF_RS06940	COG4303	Ethanolamine ammonia lyase large subunit
OG1RF_RS06970	COG2096	Adenosyltransferase
OG1RF_RS06980	COG1120	ATPase activity
OG1RF_RS06985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OG1RF_RS06990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
OG1RF_RS06995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OG1RF_RS07005	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
OG1RF_RS07010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
OG1RF_RS07015	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
OG1RF_RS07025	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
OG1RF_RS07030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OG1RF_RS07035	COG1266	CAAX protease self-immunity
OG1RF_RS07040	COG0758	DNA mediated transformation
OG1RF_RS07045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
OG1RF_RS07055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OG1RF_RS07060	COG0583	DNA-binding transcription factor activity
OG1RF_RS07070	COG0508	dehydrogenase complex catalyzes the overall conversion of
OG1RF_RS07075	COG0022	dehydrogenase e1 component
OG1RF_RS07080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
OG1RF_RS07085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OG1RF_RS07090	COG3426	butyrate kinase activity
OG1RF_RS07095	COG0280	phosphate acetyltransferase
OG1RF_RS07115	COG1028	Short-chain dehydrogenase reductase Sdr
OG1RF_RS07125	COG0346	lactoylglutathione lyase activity
OG1RF_RS07135	COG0604	alcohol dehydrogenase
OG1RF_RS07140	COG0577	efflux transmembrane transporter activity
OG1RF_RS07145	COG1136	(ABC) transporter
OG1RF_RS07155	COG1131	(ABC) transporter
OG1RF_RS07170	COG0681	Belongs to the peptidase S26 family
OG1RF_RS07175	COG3409	Peptidoglycan-binding domain 1 protein
OG1RF_RS07175	COG0793	Belongs to the peptidase S41A family
OG1RF_RS07180	COG4479	Belongs to the UPF0346 family
OG1RF_RS07185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OG1RF_RS07190	COG4698	Protein conserved in bacteria
OG1RF_RS07195	COG2755	lipolytic protein G-D-S-L family
OG1RF_RS07200	COG1307	EDD domain protein, DegV family
OG1RF_RS07205	COG1272	protein, Hemolysin III
OG1RF_RS07215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OG1RF_RS07220	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
OG1RF_RS07220	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OG1RF_RS07225	COG5416	Lipopolysaccharide assembly protein A domain
OG1RF_RS07230	COG0300	oxidoreductase activity
OG1RF_RS07235	COG1234	tRNA 3'-trailer cleavage
OG1RF_RS07245	COG1837	Belongs to the UPF0109 family
OG1RF_RS07250	COG0228	four-way junction DNA binding
OG1RF_RS07255	COG1214	PFAM Peptidase M22, glycoprotease
OG1RF_RS07255	COG0456	acetyltransferase
OG1RF_RS07260	COG0431	NADPH-dependent FMN reductase
OG1RF_RS07265	COG0789	Transcriptional regulator
OG1RF_RS07270	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OG1RF_RS07275	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
OG1RF_RS07280	COG1683	Conserved Protein
OG1RF_RS07285	COG0745	RESPONSE REGULATOR receiver
OG1RF_RS07290	COG5002	protein histidine kinase activity
OG1RF_RS07300	COG0436	Aminotransferase
OG1RF_RS07305	COG0383	alpha-mannosidase activity
OG1RF_RS07320	COG0583	DNA-binding transcription factor activity
OG1RF_RS07335	COG0284	orotidine-5'-phosphate decarboxylase activity
OG1RF_RS07350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
OG1RF_RS07355	COG0505	Belongs to the CarA family
OG1RF_RS07360	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OG1RF_RS07365	COG0540	Belongs to the ATCase OTCase family
OG1RF_RS07370	COG2233	PERMEase
OG1RF_RS07380	COG0564	pseudouridine synthase activity
OG1RF_RS07385	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OG1RF_RS07395	COG2759	Belongs to the formate--tetrahydrofolate ligase family
OG1RF_RS07400	COG1278	Cold shock
OG1RF_RS07410	COG0328	RNA-DNA hybrid ribonuclease activity
OG1RF_RS07415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OG1RF_RS07420	COG0710	3-dehydroquinate dehydratase activity
OG1RF_RS07425	COG1132	(ABC) transporter
OG1RF_RS07430	COG1132	(ABC) transporter
OG1RF_RS07435	COG3763	UPF0154 protein
OG1RF_RS07445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OG1RF_RS07460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OG1RF_RS07475	COG1131	(ABC) transporter
OG1RF_RS07480	COG1609	Transcriptional regulator
OG1RF_RS07485	COG0006	proline dipeptidase activity
OG1RF_RS07490	COG4980	gas vesicle protein
OG1RF_RS07500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
OG1RF_RS07505	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OG1RF_RS07510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OG1RF_RS07515	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
OG1RF_RS07520	COG0322	excinuclease ABC activity
OG1RF_RS07525	COG1950	PFAM Membrane protein of
OG1RF_RS07535	COG3595	metallopeptidase activity
OG1RF_RS07540	COG0704	Plays a role in the regulation of phosphate uptake
OG1RF_RS07545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OG1RF_RS07550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OG1RF_RS07555	COG0581	inorganic phosphate transmembrane transporter activity
OG1RF_RS07560	COG0573	inorganic phosphate transmembrane transporter activity
OG1RF_RS07570	COG2177	Part of the ABC transporter FtsEX involved in
OG1RF_RS07575	COG2884	Cell division ATP-binding protein ftsE
OG1RF_RS07580	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
OG1RF_RS07585	COG0653	protein targeting
OG1RF_RS07600	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
OG1RF_RS07610	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS07620	COG1739	Uncharacterized protein family UPF0029
OG1RF_RS07630	COG1028	Short-chain dehydrogenase reductase Sdr
OG1RF_RS07650	COG0151	Belongs to the GarS family
OG1RF_RS07655	COG0138	bifunctional purine biosynthesis protein purh
OG1RF_RS07660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OG1RF_RS07665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OG1RF_RS07675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OG1RF_RS07680	COG0047	phosphoribosylformylglycinamidine synthase activity
OG1RF_RS07685	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OG1RF_RS07690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OG1RF_RS07695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OG1RF_RS07700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OG1RF_RS07710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OG1RF_RS07715	COG4166	transmembrane transport
OG1RF_RS07725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OG1RF_RS07730	COG4876	unkown
OG1RF_RS07745	COG0628	permease
OG1RF_RS07750	COG0366	Alpha amylase catalytic
OG1RF_RS07750	COG1470	cell adhesion involved in biofilm formation
OG1RF_RS07760	COG3716	PTS system mannose fructose sorbose family IID component
OG1RF_RS07765	COG3715	PTS system
OG1RF_RS07770	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS07770	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS07780	COG1105	Belongs to the carbohydrate kinase PfkB family
OG1RF_RS07785	COG3684	Belongs to the aldolase LacD family
OG1RF_RS07790	COG2222	sugar isomerase
OG1RF_RS07795	COG2188	Transcriptional regulator
OG1RF_RS07800	COG1442	glycosyl transferase family 8
OG1RF_RS07805	COG1442	glycosyl transferase family 8
OG1RF_RS07810	COG1368	sulfuric ester hydrolase activity
OG1RF_RS07820	COG0583	DNA-binding transcription factor activity
OG1RF_RS07835	COG3227	Zinc metalloprotease (Elastase)
OG1RF_RS07855	COG1705	Flagellar rod assembly protein muramidase FlgJ
OG1RF_RS07855	COG3942	CHAP domain
OG1RF_RS07870	COG1064	alcohol dehydrogenase
OG1RF_RS07905	COG1606	tRNA processing
OG1RF_RS07910	COG1122	ATPase activity
OG1RF_RS07920	COG0310	cobalt ion transport
OG1RF_RS07925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OG1RF_RS07930	COG3875	lactate racemase activity
OG1RF_RS07935	COG1691	(AIR) carboxylase
OG1RF_RS07940	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
OG1RF_RS07945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OG1RF_RS07950	COG3716	PTS system mannose fructose sorbose family IID component
OG1RF_RS07960	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS07960	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS07965	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
OG1RF_RS07975	COG0698	ribose 5-phosphate isomerase
OG1RF_RS07980	COG0698	ribose 5-phosphate isomerase
OG1RF_RS07995	COG3775	system Galactitol-specific IIC component
OG1RF_RS08000	COG1349	DNA-binding transcription factor activity
OG1RF_RS08015	COG0726	polysaccharide deacetylase
OG1RF_RS08025	COG0335	large ribosomal subunit rRNA binding
OG1RF_RS08030	COG0336	Belongs to the RNA methyltransferase TrmD family
OG1RF_RS08035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OG1RF_RS08040	COG1914	H( )-stimulated, divalent metal cation uptake system
OG1RF_RS08050	COG0398	Pfam SNARE associated Golgi protein
OG1RF_RS08055	COG0584	glycerophosphoryl diester phosphodiesterase
OG1RF_RS08070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OG1RF_RS08080	COG4129	membrane
OG1RF_RS08090	COG1940	carbohydrate kinase activity
OG1RF_RS08095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OG1RF_RS08105	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OG1RF_RS08110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OG1RF_RS08115	COG2706	6-phosphogluconolactonase activity
OG1RF_RS08125	COG3069	C4-dicarboxylate transmembrane transporter activity
OG1RF_RS08155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OG1RF_RS08165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
OG1RF_RS08190	COG0366	Alpha amylase catalytic
OG1RF_RS08195	COG2190	(PTS) system
OG1RF_RS08195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS08195	COG1263	PTS System
OG1RF_RS08200	COG2188	Transcriptional regulator
OG1RF_RS08225	COG2364	Membrane
OG1RF_RS08230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OG1RF_RS08240	COG2814	Major facilitator Superfamily
OG1RF_RS08245	COG1368	sulfuric ester hydrolase activity
OG1RF_RS08275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OG1RF_RS08280	COG3716	PTS system mannose fructose sorbose family IID component
OG1RF_RS08285	COG3715	PTS system
OG1RF_RS08330	COG0149	triose-phosphate isomerase activity
OG1RF_RS08335	COG0126	phosphoglycerate kinase activity
OG1RF_RS08345	COG2390	Transcriptional regulator
OG1RF_RS08350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OG1RF_RS08355	COG4475	Protein of unknown function (DUF436)
OG1RF_RS08360	COG4720	Psort location CytoplasmicMembrane, score
OG1RF_RS08365	COG0351	phosphomethylpyrimidine kinase
OG1RF_RS08370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OG1RF_RS08375	COG0124	histidyl-tRNA synthetase
OG1RF_RS08385	COG1490	D-aminoacyl-tRNA deacylase activity
OG1RF_RS08390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OG1RF_RS08395	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OG1RF_RS08400	COG2264	protein methyltransferase activity
OG1RF_RS08410	COG2094	Belongs to the DNA glycosylase MPG family
OG1RF_RS08415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
OG1RF_RS08430	COG0589	response to stress
OG1RF_RS08435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
OG1RF_RS08440	COG0827	DNA restriction-modification system
OG1RF_RS08465	COG4537	Required for transformation and DNA binding
OG1RF_RS08475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OG1RF_RS08480	COG0531	amino acid
OG1RF_RS08485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OG1RF_RS08490	COG0577	efflux transmembrane transporter activity
OG1RF_RS08495	COG1136	(ABC) transporter
OG1RF_RS08505	COG1674	ftsk spoiiie
OG1RF_RS08510	COG1252	NADH dehydrogenase
OG1RF_RS08525	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
OG1RF_RS08530	COG4988	ABC transporter
OG1RF_RS08535	COG1294	oxidase, subunit
OG1RF_RS08540	COG1271	oxidase subunit
OG1RF_RS08545	COG2207	Transcriptional regulator
OG1RF_RS08545	COG3708	Transcriptional regulator
OG1RF_RS08565	COG1881	PFAM PEBP family protein
OG1RF_RS08580	COG0482	sulfurtransferase activity
OG1RF_RS08590	COG1104	cysteine desulfurase activity
OG1RF_RS08595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OG1RF_RS08600	COG1121	(ABC) transporter
OG1RF_RS08605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OG1RF_RS08615	COG0488	(ABC) transporter
OG1RF_RS08625	COG1473	amidohydrolase
OG1RF_RS08635	COG2011	ABC-type metal ion transport system permease component
OG1RF_RS08640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OG1RF_RS08685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OG1RF_RS08695	COG1122	ATPase activity
OG1RF_RS08700	COG4720	Psort location CytoplasmicMembrane, score
OG1RF_RS08705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OG1RF_RS08715	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
OG1RF_RS08735	COG0789	Transcriptional regulator
OG1RF_RS08740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
OG1RF_RS08745	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
OG1RF_RS08750	COG0584	glycerophosphoryl diester phosphodiesterase
OG1RF_RS08755	COG0463	Glycosyl transferase, family 2
OG1RF_RS08775	COG0463	Glycosyl transferase, family 2
OG1RF_RS08775	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
OG1RF_RS08780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OG1RF_RS08785	COG0463	Glycosyl transferase, family 2
OG1RF_RS08785	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
OG1RF_RS08790	COG1442	glycosyl transferase family 8
OG1RF_RS08790	COG1216	Glycosyl transferase, family 2
OG1RF_RS08795	COG1216	Glycosyl transferase, family 2
OG1RF_RS08805	COG3475	LICD family
OG1RF_RS08815	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OG1RF_RS08830	COG0438	transferase activity, transferring glycosyl groups
OG1RF_RS08830	COG1216	Glycosyl transferase, family 2
OG1RF_RS08835	COG0438	transferase activity, transferring glycosyl groups
OG1RF_RS08835	COG1216	Glycosyl transferase, family 2
OG1RF_RS08840	COG1134	teichoic acid transport
OG1RF_RS08845	COG1682	transport, permease protein
OG1RF_RS08860	COG1215	transferase activity, transferring glycosyl groups
OG1RF_RS08865	COG1091	dTDP-4-dehydrorhamnose reductase activity
OG1RF_RS08870	COG1088	dTDP-glucose 4,6-dehydratase activity
OG1RF_RS08880	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
OG1RF_RS08900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OG1RF_RS08905	COG1295	ribonuclease BN
OG1RF_RS08910	COG0024	Methionine aminopeptidase
OG1RF_RS08915	COG0716	FMN binding
OG1RF_RS08920	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
OG1RF_RS08925	COG1309	transcriptional regulator
OG1RF_RS08930	COG2309	aminopeptidase activity
OG1RF_RS08940	COG0590	tRNA wobble adenosine to inosine editing
OG1RF_RS08950	COG0384	phenazine biosynthesis protein PhzF
OG1RF_RS08960	COG2738	Putative neutral zinc metallopeptidase
OG1RF_RS08975	COG1263	PTS System
OG1RF_RS08975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS08980	COG0346	lactoylglutathione lyase activity
OG1RF_RS09000	COG2207	Transcriptional regulator
OG1RF_RS09000	COG4753	response regulator
OG1RF_RS09005	COG2972	Histidine kinase
OG1RF_RS09015	COG1653	transport
OG1RF_RS09020	COG0395	ABC-type sugar transport system, permease component
OG1RF_RS09025	COG1175	transmembrane transport
OG1RF_RS09045	COG1132	(ABC) transporter
OG1RF_RS09070	COG0395	ABC-type sugar transport system, permease component
OG1RF_RS09075	COG1175	transmembrane transport
OG1RF_RS09085	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
OG1RF_RS09100	COG1609	Transcriptional regulator
OG1RF_RS09115	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OG1RF_RS09120	COG1082	Xylose isomerase domain protein TIM barrel
OG1RF_RS09125	COG0673	inositol 2-dehydrogenase activity
OG1RF_RS09135	COG1012	belongs to the aldehyde dehydrogenase family
OG1RF_RS09140	COG3718	enzyme involved in inositol metabolism
OG1RF_RS09145	COG3962	Belongs to the TPP enzyme family
OG1RF_RS09150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OG1RF_RS09155	COG1609	Transcriptional regulator
OG1RF_RS09160	COG0481	GTPase activity
OG1RF_RS09175	COG0542	response to heat
OG1RF_RS09185	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OG1RF_RS09190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
OG1RF_RS09205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OG1RF_RS09215	COG1705	Flagellar rod assembly protein muramidase FlgJ
OG1RF_RS09235	COG0017	Asparaginyl-tRNA synthetase
OG1RF_RS09240	COG0436	Aminotransferase
OG1RF_RS09250	COG1199	ATP-dependent helicase activity
OG1RF_RS09250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
OG1RF_RS09260	COG0531	amino acid
OG1RF_RS09300	COG0442	prolyl-tRNA aminoacylation
OG1RF_RS09305	COG0750	zinc metalloprotease
OG1RF_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
OG1RF_RS09345	COG0719	Fe-S assembly protein
OG1RF_RS09355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OG1RF_RS09360	COG0719	Fe-S assembly protein
OG1RF_RS09370	COG0233	cytoplasmic translational termination
OG1RF_RS09375	COG0528	UMP kinase activity
OG1RF_RS09380	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OG1RF_RS09385	COG0052	Belongs to the universal ribosomal protein uS2 family
OG1RF_RS09390	COG0519	Catalyzes the synthesis of GMP from XMP
OG1RF_RS09395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OG1RF_RS09400	COG1254	Belongs to the acylphosphatase family
OG1RF_RS09405	COG0706	membrane insertase activity
OG1RF_RS09415	COG0751	glycine-tRNA ligase activity
OG1RF_RS09420	COG0752	glycyl-tRNA synthetase alpha subunit
OG1RF_RS09425	COG1381	Involved in DNA repair and RecF pathway recombination
OG1RF_RS09430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OG1RF_RS09435	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
OG1RF_RS09440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
OG1RF_RS09450	COG1702	phosphate starvation-inducible protein PhoH
OG1RF_RS09455	COG1610	YqeY-like protein
OG1RF_RS09460	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OG1RF_RS09465	COG0735	belongs to the Fur family
OG1RF_RS09470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OG1RF_RS09475	COG0083	homoserine kinase activity
OG1RF_RS09485	COG0460	homoserine dehydrogenase
OG1RF_RS09490	COG0640	Transcriptional regulator
OG1RF_RS09495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OG1RF_RS09500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OG1RF_RS09505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OG1RF_RS09520	COG0516	GMP reductase activity
OG1RF_RS09530	COG0402	S-adenosylhomocysteine deaminase activity
OG1RF_RS09545	COG1737	Transcriptional regulator
OG1RF_RS09550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS09550	COG1263	PTS System
OG1RF_RS09555	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
OG1RF_RS09565	COG2190	(PTS) system
OG1RF_RS09565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS09565	COG1263	PTS System
OG1RF_RS09570	COG1968	undecaprenyl-diphosphatase activity
OG1RF_RS09575	COG3394	polysaccharide catabolic process
OG1RF_RS09585	COG0306	phosphate transporter
OG1RF_RS09590	COG0268	Binds directly to 16S ribosomal RNA
OG1RF_RS09595	COG1607	acyl-coa hydrolase
OG1RF_RS09600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
OG1RF_RS09605	COG1466	dna polymerase III delta subunit
OG1RF_RS09610	COG0658	competence protein
OG1RF_RS09610	COG2333	competence protein COMEC
OG1RF_RS09620	COG2131	deaminase
OG1RF_RS09630	COG3480	Lon protease (S16) C-terminal proteolytic domain
OG1RF_RS09635	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OG1RF_RS09640	COG0742	ribosomal rna small subunit methyltransferase
OG1RF_RS09645	COG4471	UPF0298 protein
OG1RF_RS09660	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
OG1RF_RS09665	COG0772	Belongs to the SEDS family
OG1RF_RS09670	COG4838	Belongs to the UPF0358 family
OG1RF_RS09675	COG0514	ATP-dependent DNA helicase (RecQ)
OG1RF_RS09680	COG1217	gtp-binding protein TYPA
OG1RF_RS09685	COG0483	inositol monophosphate 1-phosphatase activity
OG1RF_RS09690	COG4476	Belongs to the UPF0223 family
OG1RF_RS09695	COG0038	chloride channel
OG1RF_RS09700	COG1215	transferase activity, transferring glycosyl groups
OG1RF_RS09730	COG0018	arginyl-trna synthetase
OG1RF_RS09735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OG1RF_RS09740	COG0456	acetyltransferase
OG1RF_RS09750	COG1214	PFAM Peptidase M22, glycoprotease
OG1RF_RS09775	COG0546	phosphoglycolate phosphatase activity
OG1RF_RS09790	COG4589	Belongs to the CDS family
OG1RF_RS09795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
OG1RF_RS09800	COG1464	Belongs to the NlpA lipoprotein family
OG1RF_RS09805	COG2011	ABC-type metal ion transport system permease component
OG1RF_RS09810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OG1RF_RS09820	COG0509	glycine decarboxylation via glycine cleavage system
OG1RF_RS09825	COG1393	Belongs to the ArsC family
OG1RF_RS09830	COG0772	Belongs to the SEDS family
OG1RF_RS09855	COG1396	sequence-specific DNA binding
OG1RF_RS09885	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
OG1RF_RS09890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OG1RF_RS09895	COG0009	L-threonylcarbamoyladenylate synthase
OG1RF_RS09900	COG2890	protein-(glutamine-N5) methyltransferase activity
OG1RF_RS09905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OG1RF_RS09910	COG1435	thymidine kinase activity
OG1RF_RS09915	COG1053	succinate dehydrogenase
OG1RF_RS09920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OG1RF_RS09930	COG0493	'glutamate synthase
OG1RF_RS09930	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
OG1RF_RS09935	COG0543	2 iron, 2 sulfur cluster binding
OG1RF_RS09940	COG0716	FMN binding
OG1RF_RS09945	COG3608	succinylglutamate desuccinylase aspartoacylase
OG1RF_RS09945	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OG1RF_RS09950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OG1RF_RS09970	COG1104	cysteine desulfurase activity
OG1RF_RS09975	COG0746	molybdenum cofactor guanylyltransferase activity
OG1RF_RS09985	COG3608	succinylglutamate desuccinylase aspartoacylase
OG1RF_RS09985	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OG1RF_RS10000	COG0251	oxidation-reduction process
OG1RF_RS10005	COG0549	Belongs to the carbamate kinase family
OG1RF_RS10010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OG1RF_RS10015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OG1RF_RS10030	COG0493	'glutamate synthase
OG1RF_RS10030	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OG1RF_RS10035	COG0402	S-adenosylhomocysteine deaminase activity
OG1RF_RS10050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OG1RF_RS10055	COG3442	glutamine amidotransferase
OG1RF_RS10060	COG1957	nucleoside hydrolase
OG1RF_RS10070	COG1482	cell wall glycoprotein biosynthetic process
OG1RF_RS10085	COG1132	(ABC) transporter
OG1RF_RS10100	COG0194	GDP metabolic process
OG1RF_RS10105	COG2723	6-phospho-beta-galactosidase activity
OG1RF_RS10110	COG2190	(PTS) system
OG1RF_RS10110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS10110	COG1263	PTS System
OG1RF_RS10115	COG3711	transcriptional antiterminator
OG1RF_RS10120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
OG1RF_RS10125	COG0628	permease
OG1RF_RS10140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OG1RF_RS10145	COG4836	Membrane
OG1RF_RS10150	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OG1RF_RS10155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
OG1RF_RS10160	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
OG1RF_RS10165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OG1RF_RS10170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OG1RF_RS10175	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OG1RF_RS10180	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OG1RF_RS10185	COG0356	it plays a direct role in the translocation of protons across the membrane
OG1RF_RS10195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OG1RF_RS10200	COG0557	exoribonuclease II activity
OG1RF_RS10215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OG1RF_RS10220	COG2388	GCN5-related N-acetyl-transferase
OG1RF_RS10225	COG3592	Divergent 4Fe-4S mono-cluster
OG1RF_RS10235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
OG1RF_RS10240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OG1RF_RS10245	COG2246	polysaccharide biosynthetic process
OG1RF_RS10250	COG1705	Flagellar rod assembly protein muramidase FlgJ
OG1RF_RS10250	COG3942	CHAP domain
OG1RF_RS10265	COG0459	protein refolding
OG1RF_RS10270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OG1RF_RS10285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
OG1RF_RS10290	COG0488	(ABC) transporter
OG1RF_RS10300	COG3448	diguanylate cyclase activity
OG1RF_RS10300	COG4175	Glycine betaine
OG1RF_RS10315	COG1597	lipid kinase activity
OG1RF_RS10320	COG3835	regulator
OG1RF_RS10325	COG1929	Belongs to the glycerate kinase type-1 family
OG1RF_RS10330	COG2610	gluconate transmembrane transporter activity
OG1RF_RS10340	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
OG1RF_RS10345	COG1177	transmembrane transport
OG1RF_RS10350	COG1176	ABC-type spermidine putrescine transport system, permease component I
OG1RF_RS10355	COG3842	ATPase activity
OG1RF_RS10365	COG0604	alcohol dehydrogenase
OG1RF_RS10375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OG1RF_RS10380	COG4684	Psort location CytoplasmicMembrane, score
OG1RF_RS10385	COG2348	transferase activity, transferring amino-acyl groups
OG1RF_RS10400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OG1RF_RS10410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OG1RF_RS10420	COG3142	Participates in the control of copper homeostasis
OG1RF_RS10425	COG2239	Acts as a magnesium transporter
OG1RF_RS10430	COG0564	pseudouridine synthase activity
OG1RF_RS10435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OG1RF_RS10440	COG2357	RelA SpoT domain protein
OG1RF_RS10445	COG4116	CYTH
OG1RF_RS10455	COG1164	Oligoendopeptidase f
OG1RF_RS10465	COG4862	establishment of competence for transformation
OG1RF_RS10470	COG1393	Belongs to the ArsC family
OG1RF_RS10475	COG0180	Tryptophanyl-tRNA synthetase
OG1RF_RS10480	COG1132	(ABC) transporter
OG1RF_RS10525	COG0419	ATPase involved in DNA repair
OG1RF_RS10530	COG0420	3'-5' exonuclease activity
OG1RF_RS10535	COG0204	Acyl-transferase
OG1RF_RS10540	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
OG1RF_RS10545	COG2827	Endonuclease containing a URI domain
OG1RF_RS10550	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
OG1RF_RS10560	COG0494	nUDIX hydrolase
OG1RF_RS10570	COG3853	Toxic anion resistance protein (TelA)
OG1RF_RS10600	COG1194	a g-specific adenine glycosylase
OG1RF_RS10605	COG2137	regulation of response to DNA damage stimulus
OG1RF_RS10610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OG1RF_RS10615	COG2261	transglycosylase associated protein
OG1RF_RS10620	COG3250	beta-galactosidase activity
OG1RF_RS10625	COG0531	amino acid
OG1RF_RS10630	COG1917	Cupin 2, conserved barrel domain protein
OG1RF_RS10630	COG2207	Transcriptional regulator
OG1RF_RS10640	COG0222	ribosome binding
OG1RF_RS10645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
OG1RF_RS10650	COG0081	regulation of translation
OG1RF_RS10655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OG1RF_RS10660	COG0488	(ABC) transporter
OG1RF_RS10665	COG1760	l-serine dehydratase
OG1RF_RS10670	COG1760	l-serine dehydratase
OG1RF_RS10680	COG1363	Peptidase, m42
OG1RF_RS10685	COG4166	transmembrane transport
OG1RF_RS10700	COG0250	Participates in transcription elongation, termination and antitermination
OG1RF_RS10705	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OG1RF_RS10710	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OG1RF_RS10725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
OG1RF_RS10735	COG0708	Exodeoxyribonuclease III
OG1RF_RS10765	COG0095	Lipoate-protein ligase
OG1RF_RS10770	COG1234	tRNA 3'-trailer cleavage
OG1RF_RS10780	COG1363	Peptidase, m42
OG1RF_RS10785	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
OG1RF_RS10790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OG1RF_RS10795	COG1696	Membrane protein involved in D-alanine export
OG1RF_RS10800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
OG1RF_RS10810	COG0577	efflux transmembrane transporter activity
OG1RF_RS10815	COG1136	(ABC) transporter
OG1RF_RS10820	COG1328	CTP reductase activity
OG1RF_RS10825	COG0602	queuosine metabolic process
OG1RF_RS10835	COG0390	transport system, permease component
OG1RF_RS10840	COG4619	ABC transporter
OG1RF_RS10850	COG4467	Involved in initiation control of chromosome replication
OG1RF_RS10855	COG1774	PSP1 C-terminal conserved region
OG1RF_RS10860	COG0470	DNA polymerase III
OG1RF_RS10865	COG3870	Protein conserved in bacteria
OG1RF_RS10870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OG1RF_RS10880	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OG1RF_RS10885	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
OG1RF_RS10895	COG1122	ATPase activity
OG1RF_RS10910	COG0477	Major facilitator Superfamily
OG1RF_RS10915	COG2814	Major facilitator Superfamily
OG1RF_RS10920	COG1733	regulation of RNA biosynthetic process
OG1RF_RS10925	COG0351	phosphomethylpyrimidine kinase
OG1RF_RS10930	COG0352	thiamine-phosphate diphosphorylase activity
OG1RF_RS10935	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
OG1RF_RS10945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OG1RF_RS10950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OG1RF_RS10955	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
OG1RF_RS10960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OG1RF_RS10975	COG3189	MarR family transcriptional regulator
OG1RF_RS10980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
OG1RF_RS10985	COG1940	carbohydrate kinase activity
OG1RF_RS11000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
OG1RF_RS11005	COG1073	alpha beta
OG1RF_RS11040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OG1RF_RS11045	COG0768	penicillin binding
OG1RF_RS11050	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OG1RF_RS11055	COG1942	4-Oxalocrotonate Tautomerase
OG1RF_RS11060	COG1876	peptidase activity
OG1RF_RS11100	COG0217	transcriptional regulatory protein
OG1RF_RS11105	COG1323	Belongs to the UPF0348 family
OG1RF_RS11110	COG2226	methyltransferase
OG1RF_RS11115	COG0799	negative regulation of ribosome biogenesis
OG1RF_RS11120	COG1713	HD superfamily hydrolase involved in NAD metabolism
OG1RF_RS11125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OG1RF_RS11130	COG1534	Rna-binding protein
OG1RF_RS11135	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
OG1RF_RS11145	COG0825	malonyl-CoA metabolic process
OG1RF_RS11150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
OG1RF_RS11155	COG0439	Biotin carboxylase
OG1RF_RS11160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OG1RF_RS11170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OG1RF_RS11180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OG1RF_RS11195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OG1RF_RS11200	COG1846	Transcriptional regulator
OG1RF_RS11205	COG4703	Protein of unknown function (DUF1797)
OG1RF_RS11210	COG2084	Dehydrogenase
OG1RF_RS11215	COG0438	transferase activity, transferring glycosyl groups
OG1RF_RS11260	COG1098	S1 RNA binding domain
OG1RF_RS11265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OG1RF_RS11280	COG0492	ferredoxin-NADP+ reductase activity
OG1RF_RS11295	COG0737	Belongs to the 5'-nucleotidase family
OG1RF_RS11315	COG1175	transmembrane transport
OG1RF_RS11320	COG3842	ATPase activity
OG1RF_RS11325	COG0463	Glycosyl transferase, family 2
OG1RF_RS11330	COG4841	protein insertion into membrane
OG1RF_RS11335	COG0569	domain protein
OG1RF_RS11340	COG2197	response regulator
OG1RF_RS11345	COG4585	Histidine kinase
OG1RF_RS11355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OG1RF_RS11360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
OG1RF_RS11370	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
OG1RF_RS11375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
OG1RF_RS11390	COG2832	Protein of unknown function (DUF454)
OG1RF_RS11395	COG5503	Protein of unknown function (DUF1447)
OG1RF_RS11405	COG1278	Cold shock
OG1RF_RS11410	COG2003	Belongs to the UPF0758 family
OG1RF_RS11415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OG1RF_RS11420	COG0285	dihydrofolate synthase activity
OG1RF_RS11435	COG0525	valine-tRNA ligase activity
OG1RF_RS11440	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
OG1RF_RS11445	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
OG1RF_RS11450	COG0301	tRNA thio-modification
OG1RF_RS11465	COG2252	PERMEase
OG1RF_RS11470	COG4221	oxidoreductase activity
OG1RF_RS11475	COG0110	maltose O-acetyltransferase activity
OG1RF_RS11480	COG0583	DNA-binding transcription factor activity
OG1RF_RS11485	COG4975	Glucose uptake
OG1RF_RS11490	COG1869	D-ribose catabolic process
OG1RF_RS11500	COG1609	Transcriptional regulator
OG1RF_RS11505	COG0657	acetylesterase activity
OG1RF_RS11520	COG3711	transcriptional antiterminator
OG1RF_RS11545	COG1834	amidinotransferase
OG1RF_RS11550	COG1785	Belongs to the alkaline phosphatase family
OG1RF_RS11555	COG1193	negative regulation of DNA recombination
OG1RF_RS11570	COG3716	PTS system mannose fructose sorbose family IID component
OG1RF_RS11575	COG3715	PTS system
OG1RF_RS11580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS11610	COG0577	efflux transmembrane transporter activity
OG1RF_RS11615	COG1136	(ABC) transporter
OG1RF_RS11620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OG1RF_RS11630	COG0446	pyridine nucleotide-disulphide oxidoreductase
OG1RF_RS11640	COG1937	Protein conserved in bacteria
OG1RF_RS11650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
OG1RF_RS11655	COG2508	Transcriptional regulator
OG1RF_RS11660	COG3257	ureidoglycine aminohydrolase activity
OG1RF_RS11665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OG1RF_RS11670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OG1RF_RS11675	COG1953	Uracil, thiamine, allantoin
OG1RF_RS11685	COG1846	Transcriptional regulator
OG1RF_RS11695	COG0659	secondary active sulfate transmembrane transporter activity
OG1RF_RS11700	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
OG1RF_RS11715	COG2508	Transcriptional regulator
OG1RF_RS11725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
OG1RF_RS11730	COG1304	FMN binding
OG1RF_RS11745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
OG1RF_RS11750	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
OG1RF_RS11785	COG1823	symporter activity
OG1RF_RS11790	COG5492	domain, Protein
OG1RF_RS11800	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OG1RF_RS11805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OG1RF_RS11810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OG1RF_RS11820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
OG1RF_RS11825	COG1363	Peptidase, m42
OG1RF_RS11840	COG4166	transmembrane transport
OG1RF_RS11845	COG3716	PTS system mannose fructose sorbose family IID component
OG1RF_RS11850	COG3715	PTS system
OG1RF_RS11855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
OG1RF_RS11865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS11880	COG3394	polysaccharide catabolic process
OG1RF_RS11890	COG0519	Catalyzes the synthesis of GMP from XMP
OG1RF_RS11920	COG3764	Sortase (surface protein transpeptidase)
OG1RF_RS11930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OG1RF_RS11960	COG1185	polyribonucleotide nucleotidyltransferase activity
OG1RF_RS11965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
OG1RF_RS11970	COG0242	peptide deformylase activity
OG1RF_RS11990	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OG1RF_RS12000	COG1268	BioY protein
OG1RF_RS12005	COG0681	Belongs to the peptidase S26 family
OG1RF_RS12025	COG4493	Belongs to the UPF0637 family
OG1RF_RS12035	COG2195	Cleaves the N-terminal amino acid of tripeptides
OG1RF_RS12040	COG4166	transmembrane transport
OG1RF_RS12045	COG4607	ABC-type enterochelin transport system periplasmic component
OG1RF_RS12050	COG4604	ABC transporter, ATP-binding protein
OG1RF_RS12055	COG4605	iron ion homeostasis
OG1RF_RS12060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OG1RF_RS12080	COG2918	glutathione biosynthetic process
OG1RF_RS12080	COG1181	Belongs to the D-alanine--D-alanine ligase family
OG1RF_RS12090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OG1RF_RS12105	COG0552	protein localization to endoplasmic reticulum
OG1RF_RS12110	COG0561	phosphatase activity
OG1RF_RS12115	COG1196	nuclear chromosome segregation
OG1RF_RS12120	COG0571	ribonuclease III activity
OG1RF_RS12135	COG0601	transmembrane transport
OG1RF_RS12140	COG4608	Belongs to the ABC transporter superfamily
OG1RF_RS12150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OG1RF_RS12155	COG0416	fatty acid biosynthetic process
OG1RF_RS12160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OG1RF_RS12165	COG1461	Dihydroxyacetone kinase
OG1RF_RS12175	COG3279	Response regulator of the LytR AlgR family
OG1RF_RS12185	COG1668	transmembrane transport
OG1RF_RS12190	COG4152	abc transporter atp-binding protein
OG1RF_RS12195	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OG1RF_RS12205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OG1RF_RS12210	COG1162	GTPase activity
OG1RF_RS12215	COG2815	serine threonine protein kinase
OG1RF_RS12215	COG0515	serine threonine protein kinase
OG1RF_RS12225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OG1RF_RS12225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OG1RF_RS12230	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OG1RF_RS12240	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OG1RF_RS12245	COG1758	RNA polymerase activity
OG1RF_RS12250	COG0194	GDP metabolic process
OG1RF_RS12280	COG0800	Aldolase
OG1RF_RS12285	COG1312	Catalyzes the dehydration of D-mannonate
OG1RF_RS12295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
OG1RF_RS12300	COG3716	PTS system mannose fructose sorbose family IID component
OG1RF_RS12310	COG0371	Dehydrogenase
OG1RF_RS12320	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
OG1RF_RS12325	COG1737	Transcriptional regulator
OG1RF_RS12340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
OG1RF_RS12375	COG1426	Protein conserved in bacteria
OG1RF_RS12380	COG0612	Peptidase, M16
OG1RF_RS12385	COG0612	Peptidase, M16
OG1RF_RS12390	COG1970	mechanosensitive ion channel activity
OG1RF_RS12405	COG2188	Transcriptional regulator
OG1RF_RS12410	COG1554	hydrolase, family 65, central catalytic
OG1RF_RS12415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
OG1RF_RS12425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OG1RF_RS12435	COG0424	maF-like protein
OG1RF_RS12440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OG1RF_RS12445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OG1RF_RS12450	COG4550	Control of competence regulator ComK, YlbF/YmcA
OG1RF_RS12455	COG1692	metallophosphoesterase
OG1RF_RS12460	COG1418	mRNA catabolic process
OG1RF_RS12465	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OG1RF_RS12470	COG1058	Belongs to the CinA family
OG1RF_RS12470	COG1546	Belongs to the CinA family
OG1RF_RS12475	COG2433	Pfam Transposase IS66
OG1RF_RS12480	COG2910	NAD(P)H-binding
OG1RF_RS12485	COG1959	2 iron, 2 sulfur cluster binding
OG1RF_RS12500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OG1RF_RS12560	COG1335	isochorismatase
OG1RF_RS12565	COG1346	cytolysis
OG1RF_RS12575	COG3279	Response regulator of the LytR AlgR family
OG1RF_RS12580	COG3275	phosphorelay sensor kinase activity
OG1RF_RS12590	COG2011	ABC-type metal ion transport system permease component
OG1RF_RS12605	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
OG1RF_RS12610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OG1RF_RS12625	COG3443	Belongs to the bacterial solute-binding protein 9 family
OG1RF_RS12625	COG0803	Belongs to the bacterial solute-binding protein 9 family
OG1RF_RS12630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OG1RF_RS12635	COG0842	Transport permease protein
OG1RF_RS12640	COG1131	(ABC) transporter
OG1RF_RS12655	COG3715	PTS system
OG1RF_RS12660	COG3716	PTS system mannose fructose sorbose family IID component
OG1RF_RS12680	COG1368	sulfuric ester hydrolase activity
OG1RF_RS12685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OG1RF_RS12690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OG1RF_RS12695	COG0783	Belongs to the Dps family
OG1RF_RS12705	COG1070	Carbohydrate kinase
OG1RF_RS12710	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
OG1RF_RS12715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OG1RF_RS12720	COG0085	RNA polymerase activity
OG1RF_RS12745	COG3397	chitin binding
OG1RF_RS12755	COG1316	TRANSCRIPTIONal
OG1RF_RS12785	COG1575	Belongs to the MenA family. Type 1 subfamily
OG1RF_RS12795	COG4939	FMN-binding domain protein
OG1RF_RS12815	COG0142	geranyltranstransferase activity
OG1RF_RS12820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OG1RF_RS12825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
OG1RF_RS12830	COG0302	gtp cyclohydrolase
OG1RF_RS12840	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OG1RF_RS12845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OG1RF_RS12880	COG2508	Transcriptional regulator
OG1RF_RS12880	COG2508	Transcriptional regulator
OG1RF_RS12885	COG0826	peptidase U32
OG1RF_RS12890	COG0826	peptidase U32
OG1RF_RS12900	COG0542	response to heat
OG1RF_RS12905	COG4463	regulation of RNA biosynthetic process
OG1RF_RS12910	COG0626	cystathionine gamma-synthase activity
OG1RF_RS12915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
OG1RF_RS12920	COG1737	Transcriptional regulator
OG1RF_RS12990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
OG1RF_RS12995	COG0517	IMP dehydrogenase activity
OG1RF_RS12995	COG0516	GMP reductase activity
OG1RF_RS13010	COG0012	GTP binding
OG1RF_RS13015	COG4481	Protein conserved in bacteria
OG1RF_RS13020	COG1475	DNA binding
OG1RF_RS13025	COG1192	Involved in chromosome partitioning
OG1RF_RS13030	COG0357	Ribosomal RNA small subunit methyltransferase G
OG1RF_RS13060	COG3732	PTS system glucitol sorbitol-specific
OG1RF_RS13065	COG3730	PTS system glucitol sorbitol-specific
OG1RF_RS13085	COG0445	tRNA wobble uridine modification
OG1RF_RS13090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OG1RF_RS13105	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
OG1RF_RS13135	COG3052	prosthetic group binding
OG1RF_RS13140	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
OG1RF_RS13150	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
OG1RF_RS13155	COG0511	ligase activity, forming carbon-carbon bonds
OG1RF_RS13165	COG2851	Citrate transporter
OG1RF_RS13175	COG0745	RESPONSE REGULATOR receiver
OG1RF_RS13185	COG0706	membrane insertase activity
OG1RF_RS13190	COG0594	ribonuclease P activity
OG1RF_RS13195	COG0230	Belongs to the bacterial ribosomal protein bL34 family