locus-tag	class	description
GFB65_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GFB65_RS00010	COG0592	DNA-directed DNA polymerase activity
GFB65_RS00015	COG2501	S4 domain
GFB65_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GFB65_RS00025	COG0187	DNA topoisomerase II activity
GFB65_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
GFB65_RS00040	COG0629	single-stranded DNA binding
GFB65_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GFB65_RS00055	COG0359	binds to the 23S rRNA
GFB65_RS00060	COG2190	(PTS) system
GFB65_RS00060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS00060	COG1263	PTS System
GFB65_RS00065	COG2723	6-phospho-beta-galactosidase activity
GFB65_RS00070	COG3711	transcriptional antiterminator
GFB65_RS00075	COG0305	Participates in initiation and elongation during chromosome replication
GFB65_RS00080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GFB65_RS00095	COG0488	(ABC) transporter
GFB65_RS00100	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GFB65_RS00100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GFB65_RS00105	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS00105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS00115	COG3715	PTS system
GFB65_RS00120	COG3716	PTS system mannose fructose sorbose family IID component
GFB65_RS00140	COG1737	Transcriptional regulator
GFB65_RS00145	COG1263	PTS System
GFB65_RS00145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS00150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GFB65_RS00155	COG0251	oxidation-reduction process
GFB65_RS00160	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GFB65_RS00160	COG0392	lysyltransferase activity
GFB65_RS00185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GFB65_RS00190	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GFB65_RS00195	COG0756	dUTP diphosphatase activity
GFB65_RS00205	COG4956	integral membrane protein (PIN domain superfamily)
GFB65_RS00210	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GFB65_RS00215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GFB65_RS00220	COG1045	serine acetyltransferase
GFB65_RS00225	COG0215	cysteine-tRNA ligase activity
GFB65_RS00230	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GFB65_RS00235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFB65_RS00240	COG3688	RNA-binding protein containing a PIN domain
GFB65_RS00250	COG4466	Protein conserved in bacteria
GFB65_RS00255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GFB65_RS00260	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFB65_RS00260	COG3443	Belongs to the bacterial solute-binding protein 9 family
GFB65_RS00265	COG1121	(ABC) transporter
GFB65_RS00270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFB65_RS00275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFB65_RS00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GFB65_RS00285	COG0737	Belongs to the 5'-nucleotidase family
GFB65_RS00290	COG4166	transmembrane transport
GFB65_RS00295	COG4224	UPF0291 protein
GFB65_RS00300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GFB65_RS00310	COG0632	four-way junction helicase activity
GFB65_RS00315	COG2255	four-way junction helicase activity
GFB65_RS00320	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GFB65_RS00325	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
GFB65_RS00325	COG3408	Glycogen debranching enzyme
GFB65_RS00335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFB65_RS00340	COG1028	Short-chain dehydrogenase reductase Sdr
GFB65_RS00365	COG2261	transglycosylase associated protein
GFB65_RS00370	COG2814	Major facilitator Superfamily
GFB65_RS00395	COG1597	lipid kinase activity
GFB65_RS00415	COG2116	formate transmembrane transporter activity
GFB65_RS00425	COG2964	Protein conserved in bacteria
GFB65_RS00435	COG1760	l-serine dehydratase
GFB65_RS00440	COG1760	l-serine dehydratase
GFB65_RS00445	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFB65_RS00455	COG1438	arginine binding
GFB65_RS00460	COG1438	arginine binding
GFB65_RS00465	COG2235	arginine
GFB65_RS00470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFB65_RS00475	COG0549	Belongs to the carbamate kinase family
GFB65_RS00485	COG1288	antiporter activity
GFB65_RS00495	COG0640	Transcriptional regulator
GFB65_RS00500	COG0604	alcohol dehydrogenase
GFB65_RS00510	COG0251	oxidation-reduction process
GFB65_RS00520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFB65_RS00545	COG1132	(ABC) transporter
GFB65_RS00635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GFB65_RS00635	COG0519	Catalyzes the synthesis of GMP from XMP
GFB65_RS00640	COG1072	(Pantothenic acid kinase))
GFB65_RS00650	COG2813	Specifically methylates the guanine in position
GFB65_RS00655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GFB65_RS00660	COG1609	Transcriptional regulator
GFB65_RS00665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GFB65_RS00670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GFB65_RS00675	COG0295	cytidine deaminase activity
GFB65_RS00680	COG1744	ABC transporter substrate-binding protein PnrA-like
GFB65_RS00685	COG1744	ABC transporter substrate-binding protein PnrA-like
GFB65_RS00690	COG3845	ABC transporter
GFB65_RS00695	COG4603	Belongs to the binding-protein-dependent transport system permease family
GFB65_RS00700	COG1079	Belongs to the binding-protein-dependent transport system permease family
GFB65_RS00710	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GFB65_RS00725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFB65_RS00730	COG1120	ATPase activity
GFB65_RS00735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFB65_RS00740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFB65_RS00745	COG1979	alcohol dehydrogenase
GFB65_RS00750	COG0588	phosphoglycerate mutase activity
GFB65_RS00755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GFB65_RS00760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GFB65_RS00765	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GFB65_RS00770	COG0049	tRNA binding
GFB65_RS00775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GFB65_RS00780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GFB65_RS00785	COG0351	phosphomethylpyrimidine kinase
GFB65_RS00790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GFB65_RS00795	COG0051	transcription antitermination factor activity, RNA binding
GFB65_RS00800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GFB65_RS00805	COG0088	Forms part of the polypeptide exit tunnel
GFB65_RS00810	COG0089	rRNA binding
GFB65_RS00815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GFB65_RS00820	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GFB65_RS00825	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GFB65_RS00830	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GFB65_RS00835	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GFB65_RS00840	COG0255	Belongs to the universal ribosomal protein uL29 family
GFB65_RS00845	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GFB65_RS00850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GFB65_RS00855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GFB65_RS00860	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GFB65_RS00865	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GFB65_RS00870	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GFB65_RS00875	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GFB65_RS00880	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GFB65_RS00885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GFB65_RS00890	COG1841	ribosomal large subunit assembly
GFB65_RS00895	COG0200	Binds to the 23S rRNA
GFB65_RS00900	COG0201	protein transport
GFB65_RS00905	COG0563	adenylate kinase activity
GFB65_RS00910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GFB65_RS00915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GFB65_RS00920	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GFB65_RS00925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GFB65_RS00930	COG0202	RNA polymerase activity
GFB65_RS00935	COG0203	ribosomal protein L17
GFB65_RS00945	COG1473	amidohydrolase
GFB65_RS00950	COG1122	ATPase activity
GFB65_RS00955	COG1122	ATPase activity
GFB65_RS00970	COG0393	Putative heavy-metal-binding
GFB65_RS00975	COG1114	Component of the transport system for branched-chain amino acids
GFB65_RS00990	COG1126	abc transporter atp-binding protein
GFB65_RS00995	COG0765	amino acid transport
GFB65_RS01005	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GFB65_RS01010	COG0110	maltose O-acetyltransferase activity
GFB65_RS01015	COG1827	regulation of RNA biosynthetic process
GFB65_RS01020	COG3942	CHAP domain
GFB65_RS01020	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB65_RS01030	COG0039	L-malate dehydrogenase activity
GFB65_RS01035	COG0193	aminoacyl-tRNA hydrolase activity
GFB65_RS01040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GFB65_RS01045	COG2244	polysaccharide biosynthetic process
GFB65_RS01050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GFB65_RS01060	COG1098	S1 RNA binding domain
GFB65_RS01065	COG0037	tRNA processing
GFB65_RS01070	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GFB65_RS01075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GFB65_RS01080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GFB65_RS01085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFB65_RS01090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GFB65_RS01235	COG3711	transcriptional antiterminator
GFB65_RS01240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS01240	COG1263	PTS System
GFB65_RS01240	COG2190	(PTS) system
GFB65_RS01245	COG2723	6-phospho-beta-galactosidase activity
GFB65_RS01250	COG2723	6-phospho-beta-galactosidase activity
GFB65_RS01260	COG0596	Alpha beta hydrolase
GFB65_RS01265	COG2169	Transcriptional regulator
GFB65_RS01270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GFB65_RS01275	COG0519	Catalyzes the synthesis of GMP from XMP
GFB65_RS01280	COG1418	mRNA catabolic process
GFB65_RS01295	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GFB65_RS01300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFB65_RS01305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFB65_RS01310	COG0167	dihydroorotate dehydrogenase activity
GFB65_RS01320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GFB65_RS01330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GFB65_RS01335	COG0626	cystathionine gamma-synthase activity
GFB65_RS01340	COG2723	6-phospho-beta-galactosidase activity
GFB65_RS01345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB65_RS01355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GFB65_RS01360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFB65_RS01375	COG2217	Heavy metal translocating P-type atpase
GFB65_RS01390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFB65_RS01395	COG3579	cysteine-type endopeptidase activity
GFB65_RS01400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GFB65_RS01405	COG0346	lactoylglutathione lyase activity
GFB65_RS01415	COG2076	Multidrug Resistance protein
GFB65_RS01420	COG3469	chitinase activity
GFB65_RS01425	COG3397	chitin binding
GFB65_RS01435	COG1801	Protein of unknown function DUF72
GFB65_RS01445	COG0527	aspartate kinase activity
GFB65_RS01450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFB65_RS01455	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GFB65_RS01460	COG1104	cysteine desulfurase activity
GFB65_RS01465	COG0745	RESPONSE REGULATOR receiver
GFB65_RS01470	COG5002	protein histidine kinase activity
GFB65_RS01490	COG0666	response to abiotic stimulus
GFB65_RS01515	COG3835	regulator
GFB65_RS01520	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GFB65_RS01535	COG0549	Belongs to the carbamate kinase family
GFB65_RS01545	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GFB65_RS01570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GFB65_RS01575	COG0628	permease
GFB65_RS01595	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GFB65_RS01600	COG1757	Na H antiporter
GFB65_RS01605	COG1846	Transcriptional regulator
GFB65_RS01610	COG0778	Nitroreductase
GFB65_RS01615	COG0561	phosphatase activity
GFB65_RS01625	COG3711	transcriptional antiterminator
GFB65_RS01630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS01640	COG2213	PTS system mannitol-specific
GFB65_RS01645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS01650	COG0246	Mannitol dehydrogenase
GFB65_RS01655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GFB65_RS01670	COG0577	efflux transmembrane transporter activity
GFB65_RS01670	COG1136	(ABC) transporter
GFB65_RS01675	COG0577	efflux transmembrane transporter activity
GFB65_RS01685	COG2814	Major facilitator Superfamily
GFB65_RS01695	COG1414	Transcriptional regulator
GFB65_RS01700	COG0800	Aldolase
GFB65_RS01710	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GFB65_RS01715	COG1028	Short-chain dehydrogenase reductase Sdr
GFB65_RS01720	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFB65_RS01745	COG1070	Carbohydrate kinase
GFB65_RS01750	COG4806	L-rhamnose isomerase
GFB65_RS01755	COG0235	Class ii aldolase
GFB65_RS01760	COG3254	rhamnose metabolic process
GFB65_RS01780	COG3104	oligopeptide transport
GFB65_RS01785	COG3942	CHAP domain
GFB65_RS01785	COG1388	LysM domain
GFB65_RS01795	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GFB65_RS01800	COG0318	PFAM AMP-dependent synthetase and ligase
GFB65_RS01805	COG1169	isochorismate synthase
GFB65_RS01810	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GFB65_RS01815	COG2267	carboxylic ester hydrolase activity
GFB65_RS01820	COG4948	Mandelate Racemase Muconate Lactonizing
GFB65_RS01825	COG0363	glucosamine-6-phosphate deaminase activity
GFB65_RS01830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GFB65_RS01835	COG1764	response to oxidative stress
GFB65_RS01850	COG3716	PTS system mannose fructose sorbose family IID component
GFB65_RS01855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS01865	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GFB65_RS01870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFB65_RS01885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GFB65_RS01890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GFB65_RS01895	COG1316	TRANSCRIPTIONal
GFB65_RS01900	COG0363	glucosamine-6-phosphate deaminase activity
GFB65_RS01905	COG1285	pathogenesis
GFB65_RS01925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GFB65_RS01930	COG1780	Probably involved in ribonucleotide reductase function
GFB65_RS01935	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GFB65_RS01975	COG1136	(ABC) transporter
GFB65_RS01990	COG0656	L-ascorbic acid biosynthetic process
GFB65_RS02000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GFB65_RS02015	COG1113	amino acid transport
GFB65_RS02020	COG1757	Na H antiporter
GFB65_RS02035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GFB65_RS02040	COG0039	L-malate dehydrogenase activity
GFB65_RS02055	COG0583	DNA-binding transcription factor activity
GFB65_RS02070	COG1733	regulation of RNA biosynthetic process
GFB65_RS02075	COG0778	Nitroreductase
GFB65_RS02080	COG0095	Lipoate-protein ligase
GFB65_RS02110	COG2514	catechol 2,3-dioxygenase activity
GFB65_RS02115	COG1349	DNA-binding transcription factor activity
GFB65_RS02130	COG0534	Mate efflux family protein
GFB65_RS02145	COG0217	transcriptional regulatory protein
GFB65_RS02160	COG0346	lactoylglutathione lyase activity
GFB65_RS02170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFB65_RS02175	COG2244	polysaccharide biosynthetic process
GFB65_RS02180	COG1187	pseudouridine synthase activity
GFB65_RS02195	COG3594	Acyltransferase
GFB65_RS02200	COG0517	IMP dehydrogenase activity
GFB65_RS02200	COG1125	glycine betaine transport
GFB65_RS02205	COG1732	Glycine betaine
GFB65_RS02210	COG1438	arginine binding
GFB65_RS02215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFB65_RS02225	COG0564	pseudouridine synthase activity
GFB65_RS02230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFB65_RS02235	COG3679	Belongs to the UPF0342 family
GFB65_RS02250	COG3481	metal-dependent phosphohydrolase, HD sub domain
GFB65_RS02255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GFB65_RS02265	COG0537	adenosine 5'-monophosphoramidase activity
GFB65_RS02270	COG1131	(ABC) transporter
GFB65_RS02275	COG4473	ABC transporter
GFB65_RS02280	COG0510	thiamine kinase activity
GFB65_RS02285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GFB65_RS02300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFB65_RS02300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS02300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFB65_RS02310	COG3684	Belongs to the aldolase LacD family
GFB65_RS02315	COG3557	Belongs to the UPF0374 family
GFB65_RS02325	COG0628	permease
GFB65_RS02330	COG1253	flavin adenine dinucleotide binding
GFB65_RS02335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GFB65_RS02340	COG4974	Belongs to the 'phage' integrase family
GFB65_RS02350	COG0582	viral genome integration into host DNA
GFB65_RS02410	COG3064	Membrane
GFB65_RS02410	COG0515	serine threonine protein kinase
GFB65_RS02410	COG4991	sh3 domain protein
GFB65_RS02440	COG0542	response to heat
GFB65_RS02450	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS02455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFB65_RS02475	COG0544	peptidyl-prolyl cis-trans isomerase activity
GFB65_RS02485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS02485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFB65_RS02485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFB65_RS02490	COG1105	Belongs to the carbohydrate kinase PfkB family
GFB65_RS02495	COG1349	DNA-binding transcription factor activity
GFB65_RS02505	COG0210	DNA helicase
GFB65_RS02510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GFB65_RS02515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFB65_RS02520	COG0154	amidase activity
GFB65_RS02525	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GFB65_RS02530	COG1597	lipid kinase activity
GFB65_RS02535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFB65_RS02545	COG2197	response regulator
GFB65_RS02550	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFB65_RS02555	COG0531	amino acid
GFB65_RS02560	COG2957	Belongs to the agmatine deiminase family
GFB65_RS02565	COG0549	Belongs to the carbamate kinase family
GFB65_RS02570	COG0154	amidase activity
GFB65_RS02580	COG1428	Deoxynucleoside kinase
GFB65_RS02610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GFB65_RS02620	COG1054	Belongs to the UPF0176 family
GFB65_RS02665	COG2217	Heavy metal translocating P-type atpase
GFB65_RS02670	COG1285	pathogenesis
GFB65_RS02680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB65_RS02685	COG0556	nucleotide-excision repair
GFB65_RS02690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GFB65_RS02700	COG1660	Displays ATPase and GTPase activities
GFB65_RS02710	COG1481	regulation of sporulation
GFB65_RS02725	COG0740	serine-type endopeptidase activity
GFB65_RS02760	COG2816	NAD+ diphosphatase activity
GFB65_RS02765	COG1278	Cold shock
GFB65_RS02775	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GFB65_RS02780	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GFB65_RS02780	COG2755	lipolytic protein G-D-S-L family
GFB65_RS02785	COG4555	ABC transporter
GFB65_RS02795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GFB65_RS02800	COG0477	Major facilitator Superfamily
GFB65_RS02815	COG1132	(ABC) transporter
GFB65_RS02820	COG1132	(ABC) transporter
GFB65_RS02825	COG1309	transcriptional regulator
GFB65_RS02830	COG0577	efflux transmembrane transporter activity
GFB65_RS02835	COG1136	(ABC) transporter
GFB65_RS02840	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GFB65_RS02845	COG1242	4 iron, 4 sulfur cluster binding
GFB65_RS02850	COG0671	phosphoesterase, PA-phosphatase related
GFB65_RS02865	COG1388	LysM domain
GFB65_RS02865	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB65_RS02870	COG0495	leucyl-tRNA aminoacylation
GFB65_RS02885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB65_RS02890	COG1126	abc transporter atp-binding protein
GFB65_RS02895	COG0765	amino acid transport
GFB65_RS02900	COG4166	transmembrane transport
GFB65_RS02920	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFB65_RS02930	COG2188	Transcriptional regulator
GFB65_RS02935	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS02935	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS02960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GFB65_RS02965	COG1187	pseudouridine synthase activity
GFB65_RS02970	COG1011	Hydrolase
GFB65_RS02985	COG2337	Toxic component of a toxin-antitoxin (TA) module
GFB65_RS02990	COG0673	inositol 2-dehydrogenase activity
GFB65_RS02995	COG3711	transcriptional antiterminator
GFB65_RS03025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB65_RS03040	COG3964	amidohydrolase
GFB65_RS03060	COG0187	DNA topoisomerase II activity
GFB65_RS03065	COG1671	Belongs to the UPF0178 family
GFB65_RS03070	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFB65_RS03075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFB65_RS03085	COG0736	holo-[acyl-carrier-protein] synthase activity
GFB65_RS03090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GFB65_RS03095	COG2337	Toxic component of a toxin-antitoxin (TA) module
GFB65_RS03110	COG0681	Belongs to the peptidase S26 family
GFB65_RS03120	COG2365	Tyrosine phosphatase family
GFB65_RS03140	COG0531	amino acid
GFB65_RS03150	COG1174	glycine betaine transport
GFB65_RS03170	COG0346	lactoylglutathione lyase activity
GFB65_RS03175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GFB65_RS03190	COG3158	transport of potassium into the cell
GFB65_RS03200	COG2217	Heavy metal translocating P-type atpase
GFB65_RS03210	COG4989	oxidoreductase activity
GFB65_RS03215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFB65_RS03215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GFB65_RS03220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GFB65_RS03225	COG0237	dephospho-CoA kinase activity
GFB65_RS03230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GFB65_RS03235	COG3611	Membrane attachment protein
GFB65_RS03240	COG1484	DNA-dependent DNA replication
GFB65_RS03285	COG1126	abc transporter atp-binding protein
GFB65_RS03290	COG0765	amino acid transport
GFB65_RS03295	COG0371	Dehydrogenase
GFB65_RS03300	COG0343	queuine tRNA-ribosyltransferase activity
GFB65_RS03305	COG1862	Preprotein translocase
GFB65_RS03315	COG1012	belongs to the aldehyde dehydrogenase family
GFB65_RS03315	COG1454	alcohol dehydrogenase
GFB65_RS03320	COG1304	FMN binding
GFB65_RS03350	COG4166	transmembrane transport
GFB65_RS03360	COG0601	transmembrane transport
GFB65_RS03365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GFB65_RS03370	COG0444	Belongs to the ABC transporter superfamily
GFB65_RS03375	COG4608	Belongs to the ABC transporter superfamily
GFB65_RS03385	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GFB65_RS03390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GFB65_RS03395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GFB65_RS03405	COG3759	membrane
GFB65_RS03415	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GFB65_RS03415	COG0456	acetyltransferase
GFB65_RS03420	COG0659	secondary active sulfate transmembrane transporter activity
GFB65_RS03425	COG2855	membrane
GFB65_RS03445	COG0745	RESPONSE REGULATOR receiver
GFB65_RS03450	COG2205	protein histidine kinase activity
GFB65_RS03455	COG4975	Glucose uptake
GFB65_RS03460	COG0531	amino acid
GFB65_RS03465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFB65_RS03465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFB65_RS03475	COG3973	AAA domain
GFB65_RS03480	COG0084	hydrolase, TatD family'
GFB65_RS03485	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GFB65_RS03490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GFB65_RS03500	COG3842	ATPase activity
GFB65_RS03505	COG1803	Methylglyoxal synthase
GFB65_RS03510	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GFB65_RS03515	COG1132	(ABC) transporter
GFB65_RS03530	COG3584	3D domain protein
GFB65_RS03545	COG0561	phosphatase activity
GFB65_RS03550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GFB65_RS03555	COG0280	phosphate acetyltransferase
GFB65_RS03560	COG0802	atpase or kinase
GFB65_RS03565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GFB65_RS03575	COG1609	Transcriptional regulator
GFB65_RS03580	COG2017	converts alpha-aldose to the beta-anomer
GFB65_RS03585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFB65_RS03595	COG1263	PTS System
GFB65_RS03595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS03595	COG2190	(PTS) system
GFB65_RS03605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFB65_RS03625	COG1131	(ABC) transporter
GFB65_RS03630	COG0789	Transcriptional regulator
GFB65_RS03645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GFB65_RS03655	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GFB65_RS03660	COG3223	Belongs to the PsiE family
GFB65_RS03665	COG1408	metallophosphoesterase
GFB65_RS03670	COG0006	proline dipeptidase activity
GFB65_RS03675	COG1694	Mazg nucleotide pyrophosphohydrolase
GFB65_RS03680	COG1302	Protein conserved in bacteria
GFB65_RS03685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFB65_RS03690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GFB65_RS03695	COG1570	exodeoxyribonuclease VII activity
GFB65_RS03700	COG1722	exodeoxyribonuclease VII activity
GFB65_RS03705	COG0142	geranyltranstransferase activity
GFB65_RS03710	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GFB65_RS03725	COG1438	arginine binding
GFB65_RS03730	COG0497	DNA recombination
GFB65_RS03750	COG2001	Belongs to the MraZ family
GFB65_RS03755	COG0275	rRNA processing
GFB65_RS03765	COG0768	penicillin binding
GFB65_RS03770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFB65_RS03775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GFB65_RS03780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GFB65_RS03790	COG0849	cell division
GFB65_RS03795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GFB65_RS03800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GFB65_RS03805	COG1799	cell septum assembly
GFB65_RS03810	COG0762	integral membrane protein
GFB65_RS03815	COG2302	S4 RNA-binding domain
GFB65_RS03820	COG3599	regulation of cell shape
GFB65_RS03825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GFB65_RS03830	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GFB65_RS03850	COG0673	inositol 2-dehydrogenase activity
GFB65_RS03860	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GFB65_RS03860	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GFB65_RS03890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB65_RS03895	COG1447	Phosphotransferase system cellobiose-specific component IIA
GFB65_RS03900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB65_RS03905	COG2723	6-phospho-beta-galactosidase activity
GFB65_RS03925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GFB65_RS03925	COG0574	Belongs to the PEP-utilizing enzyme family
GFB65_RS03930	COG0517	IMP dehydrogenase activity
GFB65_RS03935	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GFB65_RS03940	COG0392	lysyltransferase activity
GFB65_RS03940	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GFB65_RS03980	COG0105	UTP biosynthetic process
GFB65_RS03995	COG0561	phosphatase activity
GFB65_RS04005	COG2252	PERMEase
GFB65_RS04010	COG2814	Major facilitator Superfamily
GFB65_RS04020	COG0587	DNA-directed DNA polymerase activity
GFB65_RS04025	COG0205	6-phosphofructokinase activity
GFB65_RS04040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GFB65_RS04045	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GFB65_RS04050	COG0745	RESPONSE REGULATOR receiver
GFB65_RS04055	COG5002	protein histidine kinase activity
GFB65_RS04145	COG1116	anion transmembrane transporter activity
GFB65_RS04150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GFB65_RS04160	COG1914	H( )-stimulated, divalent metal cation uptake system
GFB65_RS04170	COG2508	Transcriptional regulator
GFB65_RS04175	COG4166	transmembrane transport
GFB65_RS04180	COG0402	S-adenosylhomocysteine deaminase activity
GFB65_RS04185	COG0402	S-adenosylhomocysteine deaminase activity
GFB65_RS04190	COG1956	GAF domain-containing protein
GFB65_RS04200	COG0110	maltose O-acetyltransferase activity
GFB65_RS04215	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GFB65_RS04220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFB65_RS04225	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GFB65_RS04230	COG1609	Transcriptional regulator
GFB65_RS04260	COG2814	Major facilitator Superfamily
GFB65_RS04265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GFB65_RS04295	COG0456	acetyltransferase
GFB65_RS04370	COG1132	(ABC) transporter
GFB65_RS04385	COG1113	amino acid transport
GFB65_RS04400	COG0247	lactate metabolic process
GFB65_RS04405	COG1139	Iron-sulfur cluster binding protein
GFB65_RS04420	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GFB65_RS04425	COG1074	ATP-dependent DNA helicase activity
GFB65_RS04430	COG1733	regulation of RNA biosynthetic process
GFB65_RS04435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GFB65_RS04440	COG0072	phenylalanine-tRNA ligase activity
GFB65_RS04440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFB65_RS04445	COG0765	amino acid transport
GFB65_RS04450	COG0765	amino acid transport
GFB65_RS04455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GFB65_RS04465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GFB65_RS04470	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GFB65_RS04475	COG0622	Phosphoesterase
GFB65_RS04480	COG1349	DNA-binding transcription factor activity
GFB65_RS04490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS04495	COG3037	sugar-specific permease SgaT UlaA
GFB65_RS04505	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GFB65_RS04510	COG3623	hexulose-6-phosphate isomerase
GFB65_RS04520	COG0517	IMP dehydrogenase activity
GFB65_RS04525	COG2171	N-acyltransferase activity
GFB65_RS04530	COG1473	amidohydrolase
GFB65_RS04535	COG0668	transmembrane transport
GFB65_RS04545	COG0656	L-ascorbic acid biosynthetic process
GFB65_RS04550	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GFB65_RS04570	COG1078	dGTPase activity
GFB65_RS04575	COG0095	Lipoate-protein ligase
GFB65_RS04590	COG0504	CTP synthase activity
GFB65_RS04595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GFB65_RS04600	COG3331	DNA recombination
GFB65_RS04605	COG4474	Belongs to the UPF0398 family
GFB65_RS04610	COG3599	regulation of cell shape
GFB65_RS04620	COG0116	Belongs to the methyltransferase superfamily
GFB65_RS04625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GFB65_RS04630	COG3935	DnaD domain protein
GFB65_RS04635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GFB65_RS04640	COG2188	Transcriptional regulator
GFB65_RS04650	COG1446	asparaginase
GFB65_RS04655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB65_RS04660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB65_RS04685	COG1666	GTP binding
GFB65_RS04690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFB65_RS04695	COG0191	fructose-bisphosphate aldolase activity
GFB65_RS04700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFB65_RS04705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GFB65_RS04710	COG0254	rRNA binding
GFB65_RS04720	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GFB65_RS04730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GFB65_RS04745	COG1940	carbohydrate kinase activity
GFB65_RS04750	COG3237	CsbD-like
GFB65_RS04755	COG0778	Nitroreductase
GFB65_RS04760	COG1854	S-ribosylhomocysteine lyase activity
GFB65_RS04765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GFB65_RS04770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GFB65_RS04780	COG0737	Belongs to the 5'-nucleotidase family
GFB65_RS04785	COG4470	Protein conserved in bacteria
GFB65_RS04790	COG0647	UMP catabolic process
GFB65_RS04805	COG1307	EDD domain protein, DegV family
GFB65_RS04810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFB65_RS04815	COG0745	RESPONSE REGULATOR receiver
GFB65_RS04820	COG5002	protein histidine kinase activity
GFB65_RS04835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GFB65_RS04840	COG0701	Predicted permease
GFB65_RS04845	COG3689	TIGRFAM TIGR03943 family protein
GFB65_RS04860	COG4472	Bacterial protein of unknown function (DUF965)
GFB65_RS04865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GFB65_RS04870	COG3906	Belongs to the UPF0473 family
GFB65_RS04885	COG3493	citrate carrier protein
GFB65_RS04890	COG3290	protein histidine kinase activity
GFB65_RS04895	COG4565	transcriptional regulatory protein
GFB65_RS04900	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFB65_RS04905	COG1316	TRANSCRIPTIONal
GFB65_RS04910	COG0028	Belongs to the TPP enzyme family
GFB65_RS04915	COG3527	Alpha-acetolactate decarboxylase
GFB65_RS04935	COG1175	transmembrane transport
GFB65_RS04945	COG3842	ATPase activity
GFB65_RS04955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GFB65_RS04960	COG0402	S-adenosylhomocysteine deaminase activity
GFB65_RS04980	COG3976	FMN-binding domain protein
GFB65_RS04980	COG1053	succinate dehydrogenase
GFB65_RS04980	COG0431	NADPH-dependent FMN reductase
GFB65_RS04995	COG1408	metallophosphoesterase
GFB65_RS05000	COG4209	transmembrane transport
GFB65_RS05005	COG0395	ABC-type sugar transport system, permease component
GFB65_RS05020	COG3458	cephalosporin-C deacetylase activity
GFB65_RS05035	COG3459	Glycosyltransferase 36 associated
GFB65_RS05040	COG1609	Transcriptional regulator
GFB65_RS05050	COG2188	Transcriptional regulator
GFB65_RS05055	COG2723	6-phospho-beta-galactosidase activity
GFB65_RS05060	COG0673	inositol 2-dehydrogenase activity
GFB65_RS05065	COG2707	UPF0756 membrane protein
GFB65_RS05080	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GFB65_RS05100	COG1122	ATPase activity
GFB65_RS05120	COG0561	phosphatase activity
GFB65_RS05125	COG0745	RESPONSE REGULATOR receiver
GFB65_RS05130	COG3850	Histidine kinase
GFB65_RS05130	COG5002	protein histidine kinase activity
GFB65_RS05145	COG1368	sulfuric ester hydrolase activity
GFB65_RS05150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GFB65_RS05155	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFB65_RS05160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFB65_RS05165	COG1388	LysM domain
GFB65_RS05165	COG4932	domain protein
GFB65_RS05170	COG0779	Required for maturation of 30S ribosomal subunits
GFB65_RS05175	COG0195	Participates in both transcription termination and antitermination
GFB65_RS05180	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GFB65_RS05190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GFB65_RS05195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GFB65_RS05270	COG4824	toxin secretion phage lysis holin
GFB65_RS05280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GFB65_RS05285	COG0196	riboflavin kinase activity
GFB65_RS05295	COG1695	Transcriptional regulator
GFB65_RS05315	COG0772	Belongs to the SEDS family
GFB65_RS05320	COG0583	DNA-binding transcription factor activity
GFB65_RS05325	COG0583	DNA-binding transcription factor activity
GFB65_RS05330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFB65_RS05335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GFB65_RS05340	COG1420	regulation of RNA biosynthetic process
GFB65_RS05345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GFB65_RS05350	COG0443	Heat shock 70 kDa protein
GFB65_RS05355	COG0484	heat shock protein binding
GFB65_RS05365	COG2183	response to ionizing radiation
GFB65_RS05370	COG3091	SprT-like family
GFB65_RS05380	COG0436	Aminotransferase
GFB65_RS05425	COG2268	Band 7 protein
GFB65_RS05450	COG1309	transcriptional regulator
GFB65_RS05460	COG2188	Transcriptional regulator
GFB65_RS05465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GFB65_RS05500	COG3290	protein histidine kinase activity
GFB65_RS05510	COG3279	Response regulator of the LytR AlgR family
GFB65_RS05520	COG0492	ferredoxin-NADP+ reductase activity
GFB65_RS05535	COG1136	(ABC) transporter
GFB65_RS05535	COG0577	efflux transmembrane transporter activity
GFB65_RS05535	COG1136	(ABC) transporter
GFB65_RS05535	COG0577	efflux transmembrane transporter activity
GFB65_RS05545	COG3833	ABC-type maltose transport systems, permease component
GFB65_RS05550	COG1175	transmembrane transport
GFB65_RS05555	COG2182	Extracellular solute-binding protein
GFB65_RS05560	COG0366	Alpha amylase catalytic
GFB65_RS05565	COG0366	Alpha amylase catalytic
GFB65_RS05570	COG0366	Alpha amylase catalytic
GFB65_RS05580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFB65_RS05610	COG0371	Dehydrogenase
GFB65_RS05615	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GFB65_RS05620	COG2376	Dihydroxyacetone kinase
GFB65_RS05625	COG1461	Dihydroxyacetone kinase
GFB65_RS05635	COG3425	synthase
GFB65_RS05645	COG0628	permease
GFB65_RS05655	COG1278	Cold shock
GFB65_RS05670	COG2814	Major facilitator Superfamily
GFB65_RS05675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GFB65_RS05680	COG4109	DRTGG domain
GFB65_RS05685	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GFB65_RS05690	COG2824	Alkylphosphonate utilization operon protein PhnA
GFB65_RS05705	COG0513	Belongs to the DEAD box helicase family
GFB65_RS05715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GFB65_RS05720	COG2384	SAM-dependent methyltransferase
GFB65_RS05725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GFB65_RS05730	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFB65_RS05745	COG0746	molybdenum cofactor guanylyltransferase activity
GFB65_RS05750	COG2116	formate transmembrane transporter activity
GFB65_RS05765	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GFB65_RS05770	COG3383	formate dehydrogenase (NAD+) activity
GFB65_RS05775	COG0303	'Molybdopterin
GFB65_RS05780	COG0315	cyclic pyranopterin monophosphate synthase activity
GFB65_RS05795	COG0521	Mo-molybdopterin cofactor biosynthetic process
GFB65_RS05805	COG0725	ABC transporter, periplasmic molybdate-binding protein
GFB65_RS05810	COG4149	molybdate abc transporter
GFB65_RS05815	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GFB65_RS05820	COG2217	Heavy metal translocating P-type atpase
GFB65_RS05830	COG1286	toxin biosynthetic process
GFB65_RS05835	COG1193	negative regulation of DNA recombination
GFB65_RS05840	COG3118	belongs to the thioredoxin family
GFB65_RS05845	COG0322	excinuclease ABC activity
GFB65_RS05855	COG4152	abc transporter atp-binding protein
GFB65_RS05860	COG1668	transmembrane transport
GFB65_RS05865	COG1609	Transcriptional regulator
GFB65_RS05870	COG1486	melibiose metabolic process
GFB65_RS05885	COG2081	HI0933 family
GFB65_RS05890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GFB65_RS05895	COG0166	Belongs to the GPI family
GFB65_RS05915	COG1269	ATP hydrolysis coupled proton transport
GFB65_RS05920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFB65_RS05925	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
GFB65_RS05930	COG1527	subunit (C
GFB65_RS05935	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
GFB65_RS05940	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
GFB65_RS05945	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
GFB65_RS05950	COG1394	ATPase activity, coupled to movement of substances
GFB65_RS05965	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GFB65_RS05970	COG0019	diaminopimelate decarboxylase activity
GFB65_RS05995	COG2151	metal-sulfur cluster biosynthetic enzyme
GFB65_RS06010	COG4166	transmembrane transport
GFB65_RS06015	COG3711	transcriptional antiterminator
GFB65_RS06025	COG3711	transcriptional antiterminator
GFB65_RS06025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS06035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS06035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFB65_RS06035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GFB65_RS06040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS06050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFB65_RS06055	COG0741	lytic transglycosylase activity
GFB65_RS06060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFB65_RS06065	COG0358	DNA primase activity
GFB65_RS06070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GFB65_RS06080	COG2996	Protein conserved in bacteria
GFB65_RS06085	COG0735	belongs to the Fur family
GFB65_RS06095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GFB65_RS06105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB65_RS06120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GFB65_RS06135	COG4974	Belongs to the 'phage' integrase family
GFB65_RS06140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GFB65_RS06145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GFB65_RS06150	COG1187	pseudouridine synthase activity
GFB65_RS06155	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GFB65_RS06175	COG0514	ATP-dependent DNA helicase (RecQ)
GFB65_RS06185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GFB65_RS06190	COG0539	negative regulation of cytoplasmic translation
GFB65_RS06195	COG1160	GTP binding
GFB65_RS06210	COG0457	Tetratricopeptide repeat
GFB65_RS06215	COG5582	Belongs to the UPF0302 family
GFB65_RS06220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFB65_RS06225	COG1694	Mazg nucleotide pyrophosphohydrolase
GFB65_RS06230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GFB65_RS06235	COG0617	tRNA 3'-terminal CCA addition
GFB65_RS06250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GFB65_RS06255	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GFB65_RS06265	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GFB65_RS06270	COG0287	Prephenate dehydrogenase
GFB65_RS06280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GFB65_RS06285	COG0077	Prephenate dehydratase
GFB65_RS06295	COG1307	EDD domain protein, DegV family
GFB65_RS06320	COG0488	(ABC) transporter
GFB65_RS06325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GFB65_RS06335	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GFB65_RS06340	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GFB65_RS06345	COG4224	UPF0291 protein
GFB65_RS06355	COG2814	Major facilitator Superfamily
GFB65_RS06360	COG1388	LysM domain
GFB65_RS06360	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB65_RS06370	COG0735	belongs to the Fur family
GFB65_RS06375	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFB65_RS06380	COG2816	NAD+ diphosphatase activity
GFB65_RS06395	COG2207	Transcriptional regulator
GFB65_RS06400	COG1132	(ABC) transporter
GFB65_RS06405	COG1132	(ABC) transporter
GFB65_RS06420	COG0753	catalase activity
GFB65_RS06425	COG1349	DNA-binding transcription factor activity
GFB65_RS06430	COG0546	phosphoglycolate phosphatase activity
GFB65_RS06440	COG3328	transposase activity
GFB65_RS06445	COG0415	Belongs to the DNA photolyase family
GFB65_RS06455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS06455	COG2190	(PTS) system
GFB65_RS06455	COG1263	PTS System
GFB65_RS06460	COG0366	Alpha amylase catalytic
GFB65_RS06470	COG1609	Transcriptional regulator
GFB65_RS06480	COG2723	6-phospho-beta-galactosidase activity
GFB65_RS06485	COG1263	PTS System
GFB65_RS06485	COG2190	(PTS) system
GFB65_RS06485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS06490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GFB65_RS06495	COG3639	organic phosphonate transmembrane transporter activity
GFB65_RS06510	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GFB65_RS06525	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GFB65_RS06535	COG1227	inorganic diphosphatase activity
GFB65_RS06540	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GFB65_RS06545	COG1882	Formate acetyltransferase
GFB65_RS06550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GFB65_RS06555	COG0187	DNA topoisomerase II activity
GFB65_RS06560	COG1832	CoA-binding protein
GFB65_RS06565	COG4766	ethanolamine catabolic process
GFB65_RS06570	COG3192	ethanolamine utilization protein
GFB65_RS06575	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
GFB65_RS06585	COG4869	propanediol catabolic process
GFB65_RS06600	COG1012	belongs to the aldehyde dehydrogenase family
GFB65_RS06600	COG1454	alcohol dehydrogenase
GFB65_RS06615	COG4302	ethanolamine ammonia-lyase activity
GFB65_RS06620	COG4303	Ethanolamine ammonia lyase large subunit
GFB65_RS06650	COG2096	Adenosyltransferase
GFB65_RS06660	COG1120	ATPase activity
GFB65_RS06665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFB65_RS06670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GFB65_RS06675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GFB65_RS06685	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GFB65_RS06690	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GFB65_RS06695	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GFB65_RS06705	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GFB65_RS06710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GFB65_RS06715	COG1266	CAAX protease self-immunity
GFB65_RS06720	COG0758	DNA mediated transformation
GFB65_RS06725	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GFB65_RS06735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GFB65_RS06740	COG0583	DNA-binding transcription factor activity
GFB65_RS06750	COG0508	dehydrogenase complex catalyzes the overall conversion of
GFB65_RS06755	COG0022	dehydrogenase e1 component
GFB65_RS06760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GFB65_RS06765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFB65_RS06770	COG3426	butyrate kinase activity
GFB65_RS06775	COG0280	phosphate acetyltransferase
GFB65_RS06795	COG1028	Short-chain dehydrogenase reductase Sdr
GFB65_RS06805	COG0346	lactoylglutathione lyase activity
GFB65_RS06815	COG0604	alcohol dehydrogenase
GFB65_RS06820	COG0577	efflux transmembrane transporter activity
GFB65_RS06825	COG1136	(ABC) transporter
GFB65_RS06835	COG1131	(ABC) transporter
GFB65_RS06850	COG0681	Belongs to the peptidase S26 family
GFB65_RS06855	COG3409	Peptidoglycan-binding domain 1 protein
GFB65_RS06855	COG0793	Belongs to the peptidase S41A family
GFB65_RS06860	COG4479	Belongs to the UPF0346 family
GFB65_RS06870	COG4698	Protein conserved in bacteria
GFB65_RS06875	COG2755	lipolytic protein G-D-S-L family
GFB65_RS06880	COG1307	EDD domain protein, DegV family
GFB65_RS06885	COG1272	protein, Hemolysin III
GFB65_RS06895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFB65_RS06900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GFB65_RS06900	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GFB65_RS06905	COG5416	Lipopolysaccharide assembly protein A domain
GFB65_RS06910	COG0300	oxidoreductase activity
GFB65_RS06915	COG1234	tRNA 3'-trailer cleavage
GFB65_RS06925	COG1837	Belongs to the UPF0109 family
GFB65_RS06930	COG0228	four-way junction DNA binding
GFB65_RS06935	COG0456	acetyltransferase
GFB65_RS06935	COG1214	PFAM Peptidase M22, glycoprotease
GFB65_RS06940	COG0431	NADPH-dependent FMN reductase
GFB65_RS06945	COG0789	Transcriptional regulator
GFB65_RS06950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GFB65_RS06955	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GFB65_RS06960	COG1683	Conserved Protein
GFB65_RS06965	COG0745	RESPONSE REGULATOR receiver
GFB65_RS06970	COG5002	protein histidine kinase activity
GFB65_RS06980	COG0436	Aminotransferase
GFB65_RS06985	COG0383	alpha-mannosidase activity
GFB65_RS06995	COG1609	Transcriptional regulator
GFB65_RS07000	COG0583	DNA-binding transcription factor activity
GFB65_RS07015	COG0284	orotidine-5'-phosphate decarboxylase activity
GFB65_RS07025	COG0543	2 iron, 2 sulfur cluster binding
GFB65_RS07030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GFB65_RS07035	COG0505	Belongs to the CarA family
GFB65_RS07040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFB65_RS07045	COG0540	Belongs to the ATCase OTCase family
GFB65_RS07050	COG2233	PERMEase
GFB65_RS07060	COG0564	pseudouridine synthase activity
GFB65_RS07065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GFB65_RS07075	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GFB65_RS07080	COG1278	Cold shock
GFB65_RS07090	COG0328	RNA-DNA hybrid ribonuclease activity
GFB65_RS07095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GFB65_RS07100	COG0710	3-dehydroquinate dehydratase activity
GFB65_RS07105	COG1132	(ABC) transporter
GFB65_RS07110	COG1132	(ABC) transporter
GFB65_RS07115	COG3763	UPF0154 protein
GFB65_RS07120	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GFB65_RS07135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GFB65_RS07150	COG1131	(ABC) transporter
GFB65_RS07155	COG1609	Transcriptional regulator
GFB65_RS07160	COG0006	proline dipeptidase activity
GFB65_RS07165	COG4980	gas vesicle protein
GFB65_RS07175	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GFB65_RS07180	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GFB65_RS07185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GFB65_RS07190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GFB65_RS07195	COG0322	excinuclease ABC activity
GFB65_RS07200	COG1950	PFAM Membrane protein of
GFB65_RS07210	COG3595	metallopeptidase activity
GFB65_RS07215	COG0704	Plays a role in the regulation of phosphate uptake
GFB65_RS07220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFB65_RS07225	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GFB65_RS07230	COG0581	inorganic phosphate transmembrane transporter activity
GFB65_RS07235	COG0573	inorganic phosphate transmembrane transporter activity
GFB65_RS07245	COG2177	Part of the ABC transporter FtsEX involved in
GFB65_RS07250	COG2884	Cell division ATP-binding protein ftsE
GFB65_RS07260	COG0653	protein targeting
GFB65_RS07275	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GFB65_RS07285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB65_RS07295	COG1739	Uncharacterized protein family UPF0029
GFB65_RS07305	COG1028	Short-chain dehydrogenase reductase Sdr
GFB65_RS07325	COG0151	Belongs to the GarS family
GFB65_RS07330	COG0138	bifunctional purine biosynthesis protein purh
GFB65_RS07335	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GFB65_RS07340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GFB65_RS07350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFB65_RS07355	COG0047	phosphoribosylformylglycinamidine synthase activity
GFB65_RS07360	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GFB65_RS07365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GFB65_RS07370	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFB65_RS07375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GFB65_RS07385	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GFB65_RS07390	COG4166	transmembrane transport
GFB65_RS07400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GFB65_RS07405	COG4876	unkown
GFB65_RS07420	COG0628	permease
GFB65_RS07425	COG0366	Alpha amylase catalytic
GFB65_RS07425	COG1470	cell adhesion involved in biofilm formation
GFB65_RS07435	COG3716	PTS system mannose fructose sorbose family IID component
GFB65_RS07440	COG3715	PTS system
GFB65_RS07445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GFB65_RS07445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS07455	COG1105	Belongs to the carbohydrate kinase PfkB family
GFB65_RS07460	COG3684	Belongs to the aldolase LacD family
GFB65_RS07465	COG2222	sugar isomerase
GFB65_RS07470	COG2188	Transcriptional regulator
GFB65_RS07475	COG1442	glycosyl transferase family 8
GFB65_RS07480	COG1442	glycosyl transferase family 8
GFB65_RS07490	COG1368	sulfuric ester hydrolase activity
GFB65_RS07500	COG0583	DNA-binding transcription factor activity
GFB65_RS07515	COG3227	Zinc metalloprotease (Elastase)
GFB65_RS07535	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB65_RS07535	COG3942	CHAP domain
GFB65_RS07560	COG1846	Transcriptional regulator
GFB65_RS07585	COG0335	large ribosomal subunit rRNA binding
GFB65_RS07590	COG0336	Belongs to the RNA methyltransferase TrmD family
GFB65_RS07595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GFB65_RS07600	COG1914	H( )-stimulated, divalent metal cation uptake system
GFB65_RS07610	COG0398	Pfam SNARE associated Golgi protein
GFB65_RS07615	COG0584	glycerophosphoryl diester phosphodiesterase
GFB65_RS07630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GFB65_RS07640	COG4129	membrane
GFB65_RS07650	COG1940	carbohydrate kinase activity
GFB65_RS07655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GFB65_RS07665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GFB65_RS07670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GFB65_RS07675	COG2706	6-phosphogluconolactonase activity
GFB65_RS07685	COG3069	C4-dicarboxylate transmembrane transporter activity
GFB65_RS07715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GFB65_RS07725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GFB65_RS07765	COG2364	Membrane
GFB65_RS07770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GFB65_RS07780	COG2814	Major facilitator Superfamily
GFB65_RS07785	COG1368	sulfuric ester hydrolase activity
GFB65_RS07815	COG3716	PTS system mannose fructose sorbose family IID component
GFB65_RS07820	COG3715	PTS system
GFB65_RS07840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GFB65_RS07855	COG0149	triose-phosphate isomerase activity
GFB65_RS07860	COG0126	phosphoglycerate kinase activity
GFB65_RS07870	COG2390	Transcriptional regulator
GFB65_RS07875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFB65_RS07880	COG4475	Protein of unknown function (DUF436)
GFB65_RS07885	COG4720	Psort location CytoplasmicMembrane, score
GFB65_RS07890	COG0351	phosphomethylpyrimidine kinase
GFB65_RS07895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GFB65_RS07900	COG0124	histidyl-tRNA synthetase
GFB65_RS07905	COG1490	D-aminoacyl-tRNA deacylase activity
GFB65_RS07910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GFB65_RS07915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GFB65_RS07920	COG2264	protein methyltransferase activity
GFB65_RS07930	COG2094	Belongs to the DNA glycosylase MPG family
GFB65_RS07935	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GFB65_RS07950	COG0589	response to stress
GFB65_RS07955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GFB65_RS07960	COG0827	DNA restriction-modification system
GFB65_RS07985	COG4537	Required for transformation and DNA binding
GFB65_RS07995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GFB65_RS08000	COG0531	amino acid
GFB65_RS08005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GFB65_RS08010	COG0577	efflux transmembrane transporter activity
GFB65_RS08015	COG1136	(ABC) transporter
GFB65_RS08025	COG1674	ftsk spoiiie
GFB65_RS08030	COG1252	NADH dehydrogenase
GFB65_RS08045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GFB65_RS08050	COG4988	ABC transporter
GFB65_RS08055	COG1294	oxidase, subunit
GFB65_RS08060	COG1271	oxidase subunit
GFB65_RS08065	COG2207	Transcriptional regulator
GFB65_RS08065	COG3708	Transcriptional regulator
GFB65_RS08085	COG1881	PFAM PEBP family protein
GFB65_RS08095	COG0482	sulfurtransferase activity
GFB65_RS08105	COG1104	cysteine desulfurase activity
GFB65_RS08110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFB65_RS08115	COG1121	(ABC) transporter
GFB65_RS08120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GFB65_RS08130	COG0488	(ABC) transporter
GFB65_RS08135	COG1473	amidohydrolase
GFB65_RS08145	COG2011	ABC-type metal ion transport system permease component
GFB65_RS08150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GFB65_RS08185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GFB65_RS08195	COG1122	ATPase activity
GFB65_RS08200	COG4720	Psort location CytoplasmicMembrane, score
GFB65_RS08205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFB65_RS08215	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GFB65_RS08230	COG0789	Transcriptional regulator
GFB65_RS08235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GFB65_RS08240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GFB65_RS08245	COG0584	glycerophosphoryl diester phosphodiesterase
GFB65_RS08265	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GFB65_RS08275	COG1216	Glycosyl transferase, family 2
GFB65_RS08275	COG1442	glycosyl transferase family 8
GFB65_RS08280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GFB65_RS08295	COG3475	LICD family
GFB65_RS08305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GFB65_RS08320	COG1216	Glycosyl transferase, family 2
GFB65_RS08320	COG0438	transferase activity, transferring glycosyl groups
GFB65_RS08325	COG1216	Glycosyl transferase, family 2
GFB65_RS08325	COG0438	transferase activity, transferring glycosyl groups
GFB65_RS08330	COG1134	teichoic acid transport
GFB65_RS08335	COG1682	transport, permease protein
GFB65_RS08355	COG1215	transferase activity, transferring glycosyl groups
GFB65_RS08360	COG1091	dTDP-4-dehydrorhamnose reductase activity
GFB65_RS08365	COG1088	dTDP-glucose 4,6-dehydratase activity
GFB65_RS08375	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GFB65_RS08395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GFB65_RS08400	COG1295	ribonuclease BN
GFB65_RS08405	COG0024	Methionine aminopeptidase
GFB65_RS08410	COG0716	FMN binding
GFB65_RS08415	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GFB65_RS08420	COG1309	transcriptional regulator
GFB65_RS08425	COG2309	aminopeptidase activity
GFB65_RS08440	COG0590	tRNA wobble adenosine to inosine editing
GFB65_RS08450	COG0384	phenazine biosynthesis protein PhzF
GFB65_RS08460	COG2738	Putative neutral zinc metallopeptidase
GFB65_RS08475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS08475	COG1263	PTS System
GFB65_RS08480	COG0346	lactoylglutathione lyase activity
GFB65_RS08500	COG2207	Transcriptional regulator
GFB65_RS08500	COG4753	response regulator
GFB65_RS08505	COG2972	Histidine kinase
GFB65_RS08515	COG1653	transport
GFB65_RS08520	COG0395	ABC-type sugar transport system, permease component
GFB65_RS08525	COG1175	transmembrane transport
GFB65_RS08545	COG1132	(ABC) transporter
GFB65_RS08570	COG0395	ABC-type sugar transport system, permease component
GFB65_RS08575	COG1175	transmembrane transport
GFB65_RS08585	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GFB65_RS08600	COG1609	Transcriptional regulator
GFB65_RS08610	COG0481	GTPase activity
GFB65_RS08630	COG0542	response to heat
GFB65_RS08640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GFB65_RS08645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GFB65_RS08655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GFB65_RS08665	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB65_RS08685	COG0017	Asparaginyl-tRNA synthetase
GFB65_RS08690	COG0436	Aminotransferase
GFB65_RS08700	COG1199	ATP-dependent helicase activity
GFB65_RS08700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GFB65_RS08710	COG0531	amino acid
GFB65_RS08720	COG0442	prolyl-tRNA aminoacylation
GFB65_RS08725	COG0750	zinc metalloprotease
GFB65_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
GFB65_RS08740	COG0719	Fe-S assembly protein
GFB65_RS08750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GFB65_RS08755	COG0719	Fe-S assembly protein
GFB65_RS08765	COG0233	cytoplasmic translational termination
GFB65_RS08770	COG0528	UMP kinase activity
GFB65_RS08775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GFB65_RS08780	COG0052	Belongs to the universal ribosomal protein uS2 family
GFB65_RS08790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GFB65_RS08795	COG1254	Belongs to the acylphosphatase family
GFB65_RS08800	COG0706	membrane insertase activity
GFB65_RS08810	COG0751	glycine-tRNA ligase activity
GFB65_RS08815	COG0752	glycyl-tRNA synthetase alpha subunit
GFB65_RS08820	COG1381	Involved in DNA repair and RecF pathway recombination
GFB65_RS08825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GFB65_RS08830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GFB65_RS08835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GFB65_RS08845	COG1702	phosphate starvation-inducible protein PhoH
GFB65_RS08850	COG1610	YqeY-like protein
GFB65_RS08855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GFB65_RS08860	COG0735	belongs to the Fur family
GFB65_RS08865	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GFB65_RS08870	COG0083	homoserine kinase activity
GFB65_RS08880	COG0460	homoserine dehydrogenase
GFB65_RS08885	COG0640	Transcriptional regulator
GFB65_RS08890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GFB65_RS08895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GFB65_RS08900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GFB65_RS08915	COG0516	GMP reductase activity
GFB65_RS08925	COG0402	S-adenosylhomocysteine deaminase activity
GFB65_RS08940	COG1737	Transcriptional regulator
GFB65_RS08945	COG1263	PTS System
GFB65_RS08945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS08950	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GFB65_RS08960	COG1263	PTS System
GFB65_RS08960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS08960	COG2190	(PTS) system
GFB65_RS08965	COG1968	undecaprenyl-diphosphatase activity
GFB65_RS08970	COG3394	polysaccharide catabolic process
GFB65_RS08980	COG0306	phosphate transporter
GFB65_RS08985	COG0268	Binds directly to 16S ribosomal RNA
GFB65_RS08990	COG1607	acyl-coa hydrolase
GFB65_RS08995	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GFB65_RS09000	COG1466	dna polymerase III delta subunit
GFB65_RS09005	COG2333	competence protein COMEC
GFB65_RS09005	COG0658	competence protein
GFB65_RS09010	COG2131	deaminase
GFB65_RS09015	COG1555	photosystem II stabilization
GFB65_RS09015	COG1596	polysaccharide export
GFB65_RS09020	COG3480	Lon protease (S16) C-terminal proteolytic domain
GFB65_RS09025	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GFB65_RS09030	COG0742	ribosomal rna small subunit methyltransferase
GFB65_RS09035	COG4471	UPF0298 protein
GFB65_RS09050	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GFB65_RS09055	COG0772	Belongs to the SEDS family
GFB65_RS09060	COG4838	Belongs to the UPF0358 family
GFB65_RS09065	COG0514	ATP-dependent DNA helicase (RecQ)
GFB65_RS09070	COG1217	gtp-binding protein TYPA
GFB65_RS09075	COG0483	inositol monophosphate 1-phosphatase activity
GFB65_RS09080	COG4476	Belongs to the UPF0223 family
GFB65_RS09085	COG0038	chloride channel
GFB65_RS09105	COG0018	arginyl-trna synthetase
GFB65_RS09110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GFB65_RS09115	COG0456	acetyltransferase
GFB65_RS09125	COG1214	PFAM Peptidase M22, glycoprotease
GFB65_RS09155	COG0546	phosphoglycolate phosphatase activity
GFB65_RS09170	COG1682	transport, permease protein
GFB65_RS09175	COG1388	LysM domain
GFB65_RS09175	COG1134	teichoic acid transport
GFB65_RS09180	COG0562	UDP-galactopyranose mutase
GFB65_RS09200	COG1216	Glycosyl transferase, family 2
GFB65_RS09205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GFB65_RS09205	COG1215	transferase activity, transferring glycosyl groups
GFB65_RS09210	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GFB65_RS09215	COG4589	Belongs to the CDS family
GFB65_RS09220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GFB65_RS09225	COG1464	Belongs to the NlpA lipoprotein family
GFB65_RS09230	COG2011	ABC-type metal ion transport system permease component
GFB65_RS09235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GFB65_RS09240	COG0509	glycine decarboxylation via glycine cleavage system
GFB65_RS09245	COG1393	Belongs to the ArsC family
GFB65_RS09250	COG0772	Belongs to the SEDS family
GFB65_RS09275	COG1396	sequence-specific DNA binding
GFB65_RS09305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GFB65_RS09310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GFB65_RS09315	COG0009	L-threonylcarbamoyladenylate synthase
GFB65_RS09320	COG2890	protein-(glutamine-N5) methyltransferase activity
GFB65_RS09325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GFB65_RS09330	COG1435	thymidine kinase activity
GFB65_RS09335	COG1053	succinate dehydrogenase
GFB65_RS09340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GFB65_RS09350	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
GFB65_RS09350	COG0493	'glutamate synthase
GFB65_RS09355	COG0543	2 iron, 2 sulfur cluster binding
GFB65_RS09360	COG0716	FMN binding
GFB65_RS09365	COG3608	succinylglutamate desuccinylase aspartoacylase
GFB65_RS09365	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFB65_RS09370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GFB65_RS09395	COG0746	molybdenum cofactor guanylyltransferase activity
GFB65_RS09405	COG3608	succinylglutamate desuccinylase aspartoacylase
GFB65_RS09405	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GFB65_RS09420	COG0251	oxidation-reduction process
GFB65_RS09425	COG0549	Belongs to the carbamate kinase family
GFB65_RS09430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GFB65_RS09435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFB65_RS09450	COG0493	'glutamate synthase
GFB65_RS09450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GFB65_RS09455	COG0402	S-adenosylhomocysteine deaminase activity
GFB65_RS09465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GFB65_RS09470	COG3442	glutamine amidotransferase
GFB65_RS09475	COG1957	nucleoside hydrolase
GFB65_RS09485	COG1482	cell wall glycoprotein biosynthetic process
GFB65_RS09500	COG1132	(ABC) transporter
GFB65_RS09515	COG0194	GDP metabolic process
GFB65_RS09520	COG2723	6-phospho-beta-galactosidase activity
GFB65_RS09525	COG1263	PTS System
GFB65_RS09525	COG2190	(PTS) system
GFB65_RS09525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS09530	COG3711	transcriptional antiterminator
GFB65_RS09535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GFB65_RS09540	COG0628	permease
GFB65_RS09555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GFB65_RS09560	COG4836	Membrane
GFB65_RS09565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GFB65_RS09570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GFB65_RS09575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GFB65_RS09580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GFB65_RS09585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFB65_RS09590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GFB65_RS09595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GFB65_RS09600	COG0356	it plays a direct role in the translocation of protons across the membrane
GFB65_RS09605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GFB65_RS09610	COG0557	exoribonuclease II activity
GFB65_RS09620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFB65_RS09625	COG2388	GCN5-related N-acetyl-transferase
GFB65_RS09630	COG3592	Divergent 4Fe-4S mono-cluster
GFB65_RS09640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GFB65_RS09645	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GFB65_RS09650	COG2246	polysaccharide biosynthetic process
GFB65_RS09655	COG3942	CHAP domain
GFB65_RS09655	COG1705	Flagellar rod assembly protein muramidase FlgJ
GFB65_RS09670	COG0459	protein refolding
GFB65_RS09675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GFB65_RS09690	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GFB65_RS09695	COG0488	(ABC) transporter
GFB65_RS09705	COG3448	diguanylate cyclase activity
GFB65_RS09705	COG4175	Glycine betaine
GFB65_RS09720	COG1597	lipid kinase activity
GFB65_RS09725	COG3835	regulator
GFB65_RS09730	COG1929	Belongs to the glycerate kinase type-1 family
GFB65_RS09735	COG2610	gluconate transmembrane transporter activity
GFB65_RS09740	COG0398	Pfam SNARE associated Golgi protein
GFB65_RS09745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GFB65_RS09750	COG1177	transmembrane transport
GFB65_RS09755	COG1176	ABC-type spermidine putrescine transport system, permease component I
GFB65_RS09760	COG3842	ATPase activity
GFB65_RS09770	COG0604	alcohol dehydrogenase
GFB65_RS09780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GFB65_RS09785	COG4684	Psort location CytoplasmicMembrane, score
GFB65_RS09790	COG2348	transferase activity, transferring amino-acyl groups
GFB65_RS09805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GFB65_RS09820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GFB65_RS09830	COG3142	Participates in the control of copper homeostasis
GFB65_RS09835	COG2239	Acts as a magnesium transporter
GFB65_RS09840	COG0564	pseudouridine synthase activity
GFB65_RS09845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GFB65_RS09850	COG2357	RelA SpoT domain protein
GFB65_RS09855	COG4116	CYTH
GFB65_RS09865	COG1164	Oligoendopeptidase f
GFB65_RS09875	COG4862	establishment of competence for transformation
GFB65_RS09880	COG1393	Belongs to the ArsC family
GFB65_RS09885	COG0180	Tryptophanyl-tRNA synthetase
GFB65_RS09890	COG1132	(ABC) transporter
GFB65_RS09935	COG0419	ATPase involved in DNA repair
GFB65_RS09940	COG0420	3'-5' exonuclease activity
GFB65_RS09945	COG0204	Acyl-transferase
GFB65_RS09950	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GFB65_RS09955	COG2827	Endonuclease containing a URI domain
GFB65_RS09960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GFB65_RS09970	COG0494	nUDIX hydrolase
GFB65_RS09980	COG3853	Toxic anion resistance protein (TelA)
GFB65_RS10005	COG1194	a g-specific adenine glycosylase
GFB65_RS10010	COG2137	regulation of response to DNA damage stimulus
GFB65_RS10015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GFB65_RS10025	COG2261	transglycosylase associated protein
GFB65_RS10030	COG3250	beta-galactosidase activity
GFB65_RS10035	COG0531	amino acid
GFB65_RS10040	COG2207	Transcriptional regulator
GFB65_RS10040	COG1917	Cupin 2, conserved barrel domain protein
GFB65_RS10050	COG5632	N-Acetylmuramoyl-L-alanine amidase
GFB65_RS10050	COG5263	repeat protein
GFB65_RS10245	COG3620	sequence-specific DNA binding
GFB65_RS10270	COG0582	viral genome integration into host DNA
GFB65_RS10275	COG0222	ribosome binding
GFB65_RS10280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GFB65_RS10285	COG0081	regulation of translation
GFB65_RS10290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GFB65_RS10295	COG0488	(ABC) transporter
GFB65_RS10300	COG1760	l-serine dehydratase
GFB65_RS10305	COG1760	l-serine dehydratase
GFB65_RS10315	COG1363	Peptidase, m42
GFB65_RS10320	COG4166	transmembrane transport
GFB65_RS10335	COG0250	Participates in transcription elongation, termination and antitermination
GFB65_RS10340	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GFB65_RS10345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFB65_RS10355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GFB65_RS10365	COG0708	Exodeoxyribonuclease III
GFB65_RS10395	COG0095	Lipoate-protein ligase
GFB65_RS10400	COG1234	tRNA 3'-trailer cleavage
GFB65_RS10410	COG1363	Peptidase, m42
GFB65_RS10415	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GFB65_RS10420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFB65_RS10425	COG1696	Membrane protein involved in D-alanine export
GFB65_RS10430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GFB65_RS10440	COG0577	efflux transmembrane transporter activity
GFB65_RS10445	COG1136	(ABC) transporter
GFB65_RS10450	COG1328	CTP reductase activity
GFB65_RS10455	COG0602	queuosine metabolic process
GFB65_RS10465	COG0390	transport system, permease component
GFB65_RS10470	COG4619	ABC transporter
GFB65_RS10480	COG4467	Involved in initiation control of chromosome replication
GFB65_RS10485	COG1774	PSP1 C-terminal conserved region
GFB65_RS10490	COG0470	DNA polymerase III
GFB65_RS10495	COG3870	Protein conserved in bacteria
GFB65_RS10500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GFB65_RS10505	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GFB65_RS10510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GFB65_RS10520	COG1122	ATPase activity
GFB65_RS10535	COG0477	Major facilitator Superfamily
GFB65_RS10540	COG2814	Major facilitator Superfamily
GFB65_RS10545	COG1733	regulation of RNA biosynthetic process
GFB65_RS10550	COG0351	phosphomethylpyrimidine kinase
GFB65_RS10555	COG0352	thiamine-phosphate diphosphorylase activity
GFB65_RS10560	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GFB65_RS10570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GFB65_RS10575	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GFB65_RS10580	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GFB65_RS10585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GFB65_RS10600	COG3189	MarR family transcriptional regulator
GFB65_RS10605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GFB65_RS10610	COG1940	carbohydrate kinase activity
GFB65_RS10625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GFB65_RS10630	COG1073	alpha beta
GFB65_RS10665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFB65_RS10670	COG0768	penicillin binding
GFB65_RS10675	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GFB65_RS10680	COG1942	4-Oxalocrotonate Tautomerase
GFB65_RS10710	COG0217	transcriptional regulatory protein
GFB65_RS10715	COG1323	Belongs to the UPF0348 family
GFB65_RS10720	COG2226	methyltransferase
GFB65_RS10725	COG0799	negative regulation of ribosome biogenesis
GFB65_RS10730	COG1713	HD superfamily hydrolase involved in NAD metabolism
GFB65_RS10735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GFB65_RS10740	COG1534	Rna-binding protein
GFB65_RS10745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GFB65_RS10755	COG0825	malonyl-CoA metabolic process
GFB65_RS10760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GFB65_RS10765	COG0439	Biotin carboxylase
GFB65_RS10770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GFB65_RS10780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GFB65_RS10790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GFB65_RS10805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GFB65_RS10810	COG1846	Transcriptional regulator
GFB65_RS10815	COG4703	Protein of unknown function (DUF1797)
GFB65_RS10820	COG2084	Dehydrogenase
GFB65_RS10825	COG0438	transferase activity, transferring glycosyl groups
GFB65_RS10870	COG1098	S1 RNA binding domain
GFB65_RS10875	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GFB65_RS10890	COG0492	ferredoxin-NADP+ reductase activity
GFB65_RS10900	COG0737	Belongs to the 5'-nucleotidase family
GFB65_RS10920	COG1175	transmembrane transport
GFB65_RS10925	COG3842	ATPase activity
GFB65_RS10930	COG0463	Glycosyl transferase, family 2
GFB65_RS10935	COG4841	protein insertion into membrane
GFB65_RS10940	COG0569	domain protein
GFB65_RS10945	COG2197	response regulator
GFB65_RS10950	COG4585	Histidine kinase
GFB65_RS10960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GFB65_RS10965	COG3328	transposase activity
GFB65_RS10970	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GFB65_RS10980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GFB65_RS10985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GFB65_RS11000	COG2832	Protein of unknown function (DUF454)
GFB65_RS11005	COG5503	Protein of unknown function (DUF1447)
GFB65_RS11015	COG1278	Cold shock
GFB65_RS11020	COG2003	Belongs to the UPF0758 family
GFB65_RS11025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFB65_RS11030	COG0285	dihydrofolate synthase activity
GFB65_RS11045	COG0525	valine-tRNA ligase activity
GFB65_RS11050	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GFB65_RS11055	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GFB65_RS11060	COG0301	tRNA thio-modification
GFB65_RS11065	COG2252	PERMEase
GFB65_RS11070	COG4221	oxidoreductase activity
GFB65_RS11075	COG0110	maltose O-acetyltransferase activity
GFB65_RS11080	COG0583	DNA-binding transcription factor activity
GFB65_RS11085	COG4975	Glucose uptake
GFB65_RS11090	COG1869	D-ribose catabolic process
GFB65_RS11100	COG1609	Transcriptional regulator
GFB65_RS11105	COG0657	acetylesterase activity
GFB65_RS11120	COG3711	transcriptional antiterminator
GFB65_RS11145	COG1834	amidinotransferase
GFB65_RS11150	COG1785	Belongs to the alkaline phosphatase family
GFB65_RS11155	COG1193	negative regulation of DNA recombination
GFB65_RS11170	COG3716	PTS system mannose fructose sorbose family IID component
GFB65_RS11175	COG3715	PTS system
GFB65_RS11180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS11210	COG0577	efflux transmembrane transporter activity
GFB65_RS11215	COG1136	(ABC) transporter
GFB65_RS11220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GFB65_RS11230	COG0446	pyridine nucleotide-disulphide oxidoreductase
GFB65_RS11240	COG1937	Protein conserved in bacteria
GFB65_RS11250	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GFB65_RS11255	COG2508	Transcriptional regulator
GFB65_RS11260	COG3257	ureidoglycine aminohydrolase activity
GFB65_RS11265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFB65_RS11270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GFB65_RS11275	COG1953	Uracil, thiamine, allantoin
GFB65_RS11285	COG1846	Transcriptional regulator
GFB65_RS11295	COG0659	secondary active sulfate transmembrane transporter activity
GFB65_RS11300	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GFB65_RS11315	COG2508	Transcriptional regulator
GFB65_RS11325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GFB65_RS11330	COG1304	FMN binding
GFB65_RS11345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GFB65_RS11350	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GFB65_RS11385	COG1823	symporter activity
GFB65_RS11395	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GFB65_RS11400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GFB65_RS11405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GFB65_RS11410	COG3716	PTS system mannose fructose sorbose family IID component
GFB65_RS11415	COG3715	PTS system
GFB65_RS11420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS11435	COG2188	Transcriptional regulator
GFB65_RS11445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GFB65_RS11450	COG1363	Peptidase, m42
GFB65_RS11460	COG4166	transmembrane transport
GFB65_RS11465	COG0519	Catalyzes the synthesis of GMP from XMP
GFB65_RS11495	COG3764	Sortase (surface protein transpeptidase)
GFB65_RS11505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GFB65_RS11530	COG1185	polyribonucleotide nucleotidyltransferase activity
GFB65_RS11535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GFB65_RS11540	COG0242	peptide deformylase activity
GFB65_RS11560	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GFB65_RS11565	COG1268	BioY protein
GFB65_RS11590	COG4493	Belongs to the UPF0637 family
GFB65_RS11600	COG2195	Cleaves the N-terminal amino acid of tripeptides
GFB65_RS11605	COG4166	transmembrane transport
GFB65_RS11610	COG4607	ABC-type enterochelin transport system periplasmic component
GFB65_RS11615	COG4604	ABC transporter, ATP-binding protein
GFB65_RS11620	COG4605	iron ion homeostasis
GFB65_RS11625	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GFB65_RS11645	COG2918	glutathione biosynthetic process
GFB65_RS11645	COG1181	Belongs to the D-alanine--D-alanine ligase family
GFB65_RS11655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GFB65_RS11670	COG0552	protein localization to endoplasmic reticulum
GFB65_RS11675	COG0561	phosphatase activity
GFB65_RS11680	COG1196	nuclear chromosome segregation
GFB65_RS11685	COG0571	ribonuclease III activity
GFB65_RS11700	COG0601	transmembrane transport
GFB65_RS11705	COG4608	Belongs to the ABC transporter superfamily
GFB65_RS11715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GFB65_RS11720	COG0416	fatty acid biosynthetic process
GFB65_RS11725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GFB65_RS11730	COG1461	Dihydroxyacetone kinase
GFB65_RS11740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GFB65_RS11750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GFB65_RS11755	COG1162	GTPase activity
GFB65_RS11760	COG0515	serine threonine protein kinase
GFB65_RS11760	COG2815	serine threonine protein kinase
GFB65_RS11770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GFB65_RS11770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GFB65_RS11775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GFB65_RS11785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GFB65_RS11790	COG1758	RNA polymerase activity
GFB65_RS11795	COG0194	GDP metabolic process
GFB65_RS11825	COG0800	Aldolase
GFB65_RS11830	COG1312	Catalyzes the dehydration of D-mannonate
GFB65_RS11840	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS11845	COG3716	PTS system mannose fructose sorbose family IID component
GFB65_RS11855	COG0371	Dehydrogenase
GFB65_RS11865	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GFB65_RS11870	COG1737	Transcriptional regulator
GFB65_RS11875	COG1132	(ABC) transporter
GFB65_RS11885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GFB65_RS11895	COG1426	Protein conserved in bacteria
GFB65_RS11900	COG0612	Peptidase, M16
GFB65_RS11905	COG0612	Peptidase, M16
GFB65_RS11910	COG1970	mechanosensitive ion channel activity
GFB65_RS11925	COG2188	Transcriptional regulator
GFB65_RS11930	COG1554	hydrolase, family 65, central catalytic
GFB65_RS11935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GFB65_RS11945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GFB65_RS11955	COG0424	maF-like protein
GFB65_RS11960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GFB65_RS11965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GFB65_RS11970	COG4550	Control of competence regulator ComK, YlbF/YmcA
GFB65_RS11975	COG1692	metallophosphoesterase
GFB65_RS11980	COG1418	mRNA catabolic process
GFB65_RS11985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GFB65_RS11990	COG1546	Belongs to the CinA family
GFB65_RS11990	COG1058	Belongs to the CinA family
GFB65_RS12000	COG2910	NAD(P)H-binding
GFB65_RS12005	COG1959	2 iron, 2 sulfur cluster binding
GFB65_RS12020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GFB65_RS12080	COG1335	isochorismatase
GFB65_RS12085	COG1346	cytolysis
GFB65_RS12095	COG3279	Response regulator of the LytR AlgR family
GFB65_RS12100	COG3275	phosphorelay sensor kinase activity
GFB65_RS12110	COG2011	ABC-type metal ion transport system permease component
GFB65_RS12125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GFB65_RS12130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GFB65_RS12145	COG0803	Belongs to the bacterial solute-binding protein 9 family
GFB65_RS12145	COG3443	Belongs to the bacterial solute-binding protein 9 family
GFB65_RS12150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GFB65_RS12155	COG0842	Transport permease protein
GFB65_RS12160	COG1131	(ABC) transporter
GFB65_RS12175	COG3715	PTS system
GFB65_RS12180	COG3716	PTS system mannose fructose sorbose family IID component
GFB65_RS12230	COG2190	(PTS) system
GFB65_RS12230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS12230	COG1263	PTS System
GFB65_RS12235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GFB65_RS12235	COG2190	(PTS) system
GFB65_RS12235	COG1263	PTS System
GFB65_RS12240	COG1486	melibiose metabolic process
GFB65_RS12245	COG1737	Transcriptional regulator
GFB65_RS12275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GFB65_RS12365	COG3843	relaxase mobilization nuclease domain protein
GFB65_RS12400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GFB65_RS12405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GFB65_RS12410	COG0783	Belongs to the Dps family
GFB65_RS12420	COG1070	Carbohydrate kinase
GFB65_RS12425	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GFB65_RS12430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GFB65_RS12435	COG0085	RNA polymerase activity
GFB65_RS12460	COG3397	chitin binding
GFB65_RS12465	COG1316	TRANSCRIPTIONal
GFB65_RS12505	COG1575	Belongs to the MenA family. Type 1 subfamily
GFB65_RS12515	COG4939	FMN-binding domain protein
GFB65_RS12535	COG0142	geranyltranstransferase activity
GFB65_RS12550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GFB65_RS12555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GFB65_RS12560	COG0302	gtp cyclohydrolase
GFB65_RS12570	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GFB65_RS12575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GFB65_RS12600	COG2508	Transcriptional regulator
GFB65_RS12600	COG2508	Transcriptional regulator
GFB65_RS12605	COG0826	peptidase U32
GFB65_RS12610	COG0826	peptidase U32
GFB65_RS12620	COG0542	response to heat
GFB65_RS12625	COG4463	regulation of RNA biosynthetic process
GFB65_RS12630	COG0626	cystathionine gamma-synthase activity
GFB65_RS12635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GFB65_RS12640	COG1737	Transcriptional regulator
GFB65_RS12710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GFB65_RS12715	COG0517	IMP dehydrogenase activity
GFB65_RS12715	COG0516	GMP reductase activity
GFB65_RS12730	COG0012	GTP binding
GFB65_RS12735	COG4481	Protein conserved in bacteria
GFB65_RS12740	COG1475	DNA binding
GFB65_RS12745	COG1192	Involved in chromosome partitioning
GFB65_RS12750	COG0357	Ribosomal RNA small subunit methyltransferase G
GFB65_RS12775	COG3732	PTS system glucitol sorbitol-specific
GFB65_RS12780	COG3730	PTS system glucitol sorbitol-specific
GFB65_RS12800	COG0445	tRNA wobble uridine modification
GFB65_RS12805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GFB65_RS12815	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GFB65_RS12845	COG3052	prosthetic group binding
GFB65_RS12850	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GFB65_RS12855	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GFB65_RS12860	COG0511	ligase activity, forming carbon-carbon bonds
GFB65_RS12870	COG2851	Citrate transporter
GFB65_RS12880	COG0745	RESPONSE REGULATOR receiver
GFB65_RS12890	COG0706	membrane insertase activity
GFB65_RS12895	COG0594	ribonuclease P activity
GFB65_RS12900	COG0230	Belongs to the bacterial ribosomal protein bL34 family