locus-tag	class	description
HI843_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HI843_RS00010	COG0592	DNA-directed DNA polymerase activity
HI843_RS00015	COG2501	S4 domain
HI843_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HI843_RS00025	COG0187	DNA topoisomerase II activity
HI843_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
HI843_RS00040	COG0629	single-stranded DNA binding
HI843_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HI843_RS00055	COG0359	binds to the 23S rRNA
HI843_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
HI843_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HI843_RS00075	COG0488	(ABC) transporter
HI843_RS00085	COG0028	Belongs to the TPP enzyme family
HI843_RS00155	COG2723	6-phospho-beta-galactosidase activity
HI843_RS00165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS00165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS00175	COG0519	Catalyzes the synthesis of GMP from XMP
HI843_RS00175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HI843_RS00180	COG1072	(Pantothenic acid kinase))
HI843_RS00185	COG2813	Specifically methylates the guanine in position
HI843_RS00190	COG1609	Transcriptional regulator
HI843_RS00195	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HI843_RS00200	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HI843_RS00205	COG0295	cytidine deaminase activity
HI843_RS00210	COG1744	ABC transporter substrate-binding protein PnrA-like
HI843_RS00230	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HI843_RS00240	COG0813	purine-nucleoside phosphorylase activity
HI843_RS00245	COG0588	phosphoglycerate mutase activity
HI843_RS00255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HI843_RS00260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HI843_RS00265	COG0049	tRNA binding
HI843_RS00270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HI843_RS00275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HI843_RS00280	COG0051	transcription antitermination factor activity, RNA binding
HI843_RS00285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HI843_RS00290	COG0088	Forms part of the polypeptide exit tunnel
HI843_RS00295	COG0089	rRNA binding
HI843_RS00300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HI843_RS00310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HI843_RS00315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HI843_RS00320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HI843_RS00325	COG0255	Belongs to the universal ribosomal protein uL29 family
HI843_RS00330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HI843_RS00335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HI843_RS00340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HI843_RS00345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HI843_RS00350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HI843_RS00355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HI843_RS00360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HI843_RS00365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HI843_RS00370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HI843_RS00375	COG1841	ribosomal large subunit assembly
HI843_RS00380	COG0200	Binds to the 23S rRNA
HI843_RS00385	COG0201	protein transport
HI843_RS00390	COG0563	adenylate kinase activity
HI843_RS00395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HI843_RS00400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HI843_RS00405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HI843_RS00410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HI843_RS00415	COG0202	RNA polymerase activity
HI843_RS00420	COG0203	ribosomal protein L17
HI843_RS00425	COG1122	ATPase activity
HI843_RS00430	COG1122	ATPase activity
HI843_RS00440	COG0101	tRNA pseudouridine synthase activity
HI843_RS00450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HI843_RS00460	COG1461	Dihydroxyacetone kinase
HI843_RS00465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HI843_RS00470	COG0416	fatty acid biosynthetic process
HI843_RS00475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HI843_RS00485	COG4608	Belongs to the ABC transporter superfamily
HI843_RS00490	COG0601	transmembrane transport
HI843_RS00505	COG0571	ribonuclease III activity
HI843_RS00510	COG1196	nuclear chromosome segregation
HI843_RS00515	COG0561	phosphatase activity
HI843_RS00520	COG0552	protein localization to endoplasmic reticulum
HI843_RS00525	COG1181	Belongs to the D-alanine--D-alanine ligase family
HI843_RS00525	COG2918	glutathione biosynthetic process
HI843_RS00535	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HI843_RS00540	COG4605	iron ion homeostasis
HI843_RS00545	COG4604	ABC transporter, ATP-binding protein
HI843_RS00550	COG4607	ABC-type enterochelin transport system periplasmic component
HI843_RS00575	COG4886	Leucine-rich repeat (LRR) protein
HI843_RS00575	COG4932	domain protein
HI843_RS00595	COG1380	Effector of murein hydrolase LrgA
HI843_RS00615	COG1028	Short-chain dehydrogenase reductase Sdr
HI843_RS00625	COG1268	BioY protein
HI843_RS00630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HI843_RS00645	COG0561	phosphatase activity
HI843_RS00650	COG1692	metallophosphoesterase
HI843_RS00660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HI843_RS00670	COG0424	maF-like protein
HI843_RS00675	COG1263	PTS System
HI843_RS00675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS00680	COG2188	Transcriptional regulator
HI843_RS00690	COG0632	four-way junction helicase activity
HI843_RS00695	COG2255	four-way junction helicase activity
HI843_RS00705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HI843_RS00715	COG1114	Component of the transport system for branched-chain amino acids
HI843_RS00725	COG1113	amino acid transport
HI843_RS00730	COG1126	abc transporter atp-binding protein
HI843_RS00735	COG0765	amino acid transport
HI843_RS00745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HI843_RS00750	COG0110	maltose O-acetyltransferase activity
HI843_RS00755	COG1827	regulation of RNA biosynthetic process
HI843_RS00760	COG0242	peptide deformylase activity
HI843_RS00765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HI843_RS00770	COG1185	polyribonucleotide nucleotidyltransferase activity
HI843_RS00780	COG3158	transport of potassium into the cell
HI843_RS00785	COG1253	flavin adenine dinucleotide binding
HI843_RS00790	COG0534	Mate efflux family protein
HI843_RS00800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HI843_RS00805	COG1187	pseudouridine synthase activity
HI843_RS00810	COG1011	Hydrolase
HI843_RS00815	COG0572	uridine kinase
HI843_RS00840	COG1671	Belongs to the UPF0178 family
HI843_RS00850	COG1181	Belongs to the D-alanine--D-alanine ligase family
HI843_RS00855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HI843_RS00865	COG0736	holo-[acyl-carrier-protein] synthase activity
HI843_RS00870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HI843_RS00875	COG2337	Toxic component of a toxin-antitoxin (TA) module
HI843_RS00880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HI843_RS00885	COG0604	alcohol dehydrogenase
HI843_RS00885	COG3321	synthase
HI843_RS00895	COG0531	amino acid
HI843_RS00920	COG1174	glycine betaine transport
HI843_RS00940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HI843_RS00955	COG0343	queuine tRNA-ribosyltransferase activity
HI843_RS00960	COG1862	Preprotein translocase
HI843_RS00965	COG1012	belongs to the aldehyde dehydrogenase family
HI843_RS00965	COG1454	alcohol dehydrogenase
HI843_RS00970	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HI843_RS01000	COG1917	Cupin 2, conserved barrel domain protein
HI843_RS01000	COG2207	Transcriptional regulator
HI843_RS01005	COG1070	Carbohydrate kinase
HI843_RS01010	COG4806	L-rhamnose isomerase
HI843_RS01015	COG0235	Class ii aldolase
HI843_RS01020	COG3254	rhamnose metabolic process
HI843_RS01025	COG1454	alcohol dehydrogenase
HI843_RS01030	COG1414	Transcriptional regulator
HI843_RS01035	COG0800	Aldolase
HI843_RS01045	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HI843_RS01050	COG1028	Short-chain dehydrogenase reductase Sdr
HI843_RS01060	COG1304	FMN binding
HI843_RS01075	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HI843_RS01080	COG1428	Deoxynucleoside kinase
HI843_RS01095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HI843_RS01100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HI843_RS01105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HI843_RS01135	COG0824	Thioesterase
HI843_RS01140	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HI843_RS01160	COG1363	Peptidase, m42
HI843_RS01165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI843_RS01170	COG0589	response to stress
HI843_RS01175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI843_RS01180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HI843_RS01185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HI843_RS01190	COG4807	Protein conserved in bacteria
HI843_RS01200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HI843_RS01215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HI843_RS01280	COG1368	sulfuric ester hydrolase activity
HI843_RS01290	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HI843_RS01300	COG0101	tRNA pseudouridine synthase activity
HI843_RS01335	COG2186	Transcriptional regulator
HI843_RS01340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS01345	COG2723	6-phospho-beta-galactosidase activity
HI843_RS01355	COG1447	Phosphotransferase system cellobiose-specific component IIA
HI843_RS01360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS01375	COG1063	alcohol dehydrogenase
HI843_RS01390	COG4716	Myosin-crossreactive antigen
HI843_RS01430	COG1113	amino acid transport
HI843_RS01455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HI843_RS01465	COG3052	prosthetic group binding
HI843_RS01530	COG1051	belongs to the nudix hydrolase family
HI843_RS01535	COG1846	Transcriptional regulator
HI843_RS01560	COG2252	PERMEase
HI843_RS01565	COG0366	Alpha amylase catalytic
HI843_RS01570	COG2723	6-phospho-beta-galactosidase activity
HI843_RS01580	COG2190	(PTS) system
HI843_RS01580	COG1263	PTS System
HI843_RS01580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS01585	COG2723	6-phospho-beta-galactosidase activity
HI843_RS01595	COG1902	pentaerythritol trinitrate reductase activity
HI843_RS01605	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI843_RS01615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HI843_RS01620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HI843_RS01625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HI843_RS01635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HI843_RS01645	COG1937	Protein conserved in bacteria
HI843_RS01650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HI843_RS01655	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI843_RS01660	COG3973	AAA domain
HI843_RS01685	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HI843_RS01690	COG2376	Dihydroxyacetone kinase
HI843_RS01695	COG1461	Dihydroxyacetone kinase
HI843_RS01705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI843_RS01715	COG1131	(ABC) transporter
HI843_RS01720	COG1309	transcriptional regulator
HI843_RS01740	COG0531	amino acid
HI843_RS01750	COG1609	Transcriptional regulator
HI843_RS01760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI843_RS01770	COG2190	(PTS) system
HI843_RS01770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS01770	COG1263	PTS System
HI843_RS01795	COG3479	Phenolic acid decarboxylase
HI843_RS01800	COG1695	Transcriptional regulator
HI843_RS01810	COG2814	Major facilitator Superfamily
HI843_RS01830	COG0163	prenyltransferase activity
HI843_RS01835	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HI843_RS01845	COG0577	efflux transmembrane transporter activity
HI843_RS01845	COG1136	(ABC) transporter
HI843_RS01855	COG5002	protein histidine kinase activity
HI843_RS01865	COG1811	Na channel or pump
HI843_RS01900	COG1136	(ABC) transporter
HI843_RS01915	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI843_RS01915	COG3942	CHAP domain
HI843_RS01920	COG2190	(PTS) system
HI843_RS01920	COG1263	PTS System
HI843_RS01920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS01925	COG1869	D-ribose catabolic process
HI843_RS01955	COG0366	Alpha amylase catalytic
HI843_RS01960	COG0628	permease
HI843_RS01965	COG3443	Belongs to the bacterial solute-binding protein 9 family
HI843_RS01965	COG0803	Belongs to the bacterial solute-binding protein 9 family
HI843_RS01990	COG1428	Deoxynucleoside kinase
HI843_RS02000	COG0210	DNA helicase
HI843_RS02005	COG1393	Belongs to the ArsC family
HI843_RS02010	COG1393	Belongs to the ArsC family
HI843_RS02030	COG0386	Belongs to the glutathione peroxidase family
HI843_RS02035	COG1854	S-ribosylhomocysteine lyase activity
HI843_RS02040	COG0626	cystathionine gamma-synthase activity
HI843_RS02045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HI843_RS02050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HI843_RS02060	COG0019	diaminopimelate decarboxylase activity
HI843_RS02065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HI843_RS02075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HI843_RS02080	COG2171	N-acyltransferase activity
HI843_RS02085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HI843_RS02090	COG0527	aspartate kinase activity
HI843_RS02095	COG1473	amidohydrolase
HI843_RS02100	COG0436	Aminotransferase
HI843_RS02105	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI843_RS02125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HI843_RS02130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HI843_RS02145	COG2207	Transcriptional regulator
HI843_RS02150	COG2249	NAD(P)H dehydrogenase (quinone) activity
HI843_RS02165	COG1113	amino acid transport
HI843_RS02170	COG1121	(ABC) transporter
HI843_RS02175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HI843_RS02190	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HI843_RS02195	COG2823	Periplasmic or secreted lipoprotein
HI843_RS02195	COG1652	LysM domain
HI843_RS02205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HI843_RS02210	COG0477	Major facilitator Superfamily
HI843_RS02220	COG1438	arginine binding
HI843_RS02235	COG1764	response to oxidative stress
HI843_RS02240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HI843_RS02245	COG1335	isochorismatase
HI843_RS02260	COG2135	peptidase activity
HI843_RS02295	COG3546	catalase activity
HI843_RS02305	COG1175	transmembrane transport
HI843_RS02310	COG0395	ABC-type sugar transport system, permease component
HI843_RS02350	COG0745	RESPONSE REGULATOR receiver
HI843_RS02355	COG2205	protein histidine kinase activity
HI843_RS02360	COG4975	Glucose uptake
HI843_RS02365	COG0531	amino acid
HI843_RS02370	COG3853	Toxic anion resistance protein (TelA)
HI843_RS02390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HI843_RS02395	COG1335	isochorismatase
HI843_RS02405	COG3590	peptidase
HI843_RS02420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HI843_RS02425	COG1104	cysteine desulfurase activity
HI843_RS02445	COG0482	sulfurtransferase activity
HI843_RS02455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HI843_RS02460	COG2814	Major facilitator Superfamily
HI843_RS02480	COG0463	Glycosyl transferase, family 2
HI843_RS02485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HI843_RS02490	COG2855	membrane
HI843_RS02500	COG0583	DNA-binding transcription factor activity
HI843_RS02505	COG0772	Belongs to the SEDS family
HI843_RS02510	COG1393	Belongs to the ArsC family
HI843_RS02515	COG0509	glycine decarboxylation via glycine cleavage system
HI843_RS02520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HI843_RS02525	COG2011	ABC-type metal ion transport system permease component
HI843_RS02530	COG1464	Belongs to the NlpA lipoprotein family
HI843_RS02540	COG0719	Fe-S assembly protein
HI843_RS02545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HI843_RS02600	COG1263	PTS System
HI843_RS02600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS02600	COG2190	(PTS) system
HI843_RS02605	COG2723	6-phospho-beta-galactosidase activity
HI843_RS02610	COG3711	transcriptional antiterminator
HI843_RS02630	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HI843_RS02645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS02645	COG1263	PTS System
HI843_RS02670	COG0800	Aldolase
HI843_RS02685	COG3775	system Galactitol-specific IIC component
HI843_RS02720	COG2188	Transcriptional regulator
HI843_RS02730	COG2222	sugar isomerase
HI843_RS02735	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HI843_RS02735	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HI843_RS02750	COG3715	PTS system
HI843_RS02755	COG3716	PTS system mannose fructose sorbose family IID component
HI843_RS02760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HI843_RS02765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HI843_RS02790	COG3716	PTS system mannose fructose sorbose family IID component
HI843_RS02795	COG3715	PTS system
HI843_RS02800	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS02800	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS02835	COG3715	PTS system
HI843_RS02840	COG3716	PTS system mannose fructose sorbose family IID component
HI843_RS02855	COG1940	carbohydrate kinase activity
HI843_RS02870	COG0577	efflux transmembrane transporter activity
HI843_RS02870	COG1136	(ABC) transporter
HI843_RS02880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HI843_RS02890	COG1597	lipid kinase activity
HI843_RS02925	COG1733	regulation of RNA biosynthetic process
HI843_RS02935	COG3764	Sortase (surface protein transpeptidase)
HI843_RS02940	COG3711	transcriptional antiterminator
HI843_RS02945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS02945	COG2190	(PTS) system
HI843_RS02945	COG1263	PTS System
HI843_RS02950	COG2723	6-phospho-beta-galactosidase activity
HI843_RS02970	COG1611	Belongs to the LOG family
HI843_RS02980	COG1428	Deoxynucleoside kinase
HI843_RS02990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS02995	COG1472	Belongs to the glycosyl hydrolase 3 family
HI843_RS03005	COG2723	6-phospho-beta-galactosidase activity
HI843_RS03020	COG1368	sulfuric ester hydrolase activity
HI843_RS03030	COG0105	UTP biosynthetic process
HI843_RS03035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI843_RS03045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HI843_RS03050	COG2011	ABC-type metal ion transport system permease component
HI843_RS03055	COG1464	Belongs to the NlpA lipoprotein family
HI843_RS03060	COG1473	amidohydrolase
HI843_RS03075	COG1113	amino acid transport
HI843_RS03085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HI843_RS03090	COG1929	Belongs to the glycerate kinase type-1 family
HI843_RS03095	COG0488	(ABC) transporter
HI843_RS03110	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HI843_RS03115	COG1263	PTS System
HI843_RS03115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS03120	COG1780	Probably involved in ribonucleotide reductase function
HI843_RS03130	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HI843_RS03135	COG1131	(ABC) transporter
HI843_RS03155	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HI843_RS03170	COG0346	lactoylglutathione lyase activity
HI843_RS03195	COG0561	phosphatase activity
HI843_RS03200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HI843_RS03205	COG0280	phosphate acetyltransferase
HI843_RS03210	COG0802	atpase or kinase
HI843_RS03215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HI843_RS03225	COG0708	Exodeoxyribonuclease III
HI843_RS03235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HI843_RS03260	COG1053	succinate dehydrogenase
HI843_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
HI843_RS03265	COG0604	alcohol dehydrogenase
HI843_RS03265	COG3321	synthase
HI843_RS03270	COG0702	epimerase
HI843_RS03275	COG4684	Psort location CytoplasmicMembrane, score
HI843_RS03280	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HI843_RS03285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HI843_RS03290	COG0604	alcohol dehydrogenase
HI843_RS03300	COG3842	ATPase activity
HI843_RS03305	COG1176	ABC-type spermidine putrescine transport system, permease component I
HI843_RS03310	COG1177	transmembrane transport
HI843_RS03315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HI843_RS03335	COG3715	PTS system
HI843_RS03340	COG3716	PTS system mannose fructose sorbose family IID component
HI843_RS03355	COG1940	carbohydrate kinase activity
HI843_RS03385	COG0582	viral genome integration into host DNA
HI843_RS03390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HI843_RS03400	COG0789	Transcriptional regulator
HI843_RS03410	COG0504	CTP synthase activity
HI843_RS03420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HI843_RS03425	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HI843_RS03430	COG0254	rRNA binding
HI843_RS03450	COG1349	DNA-binding transcription factor activity
HI843_RS03460	COG2814	Major facilitator Superfamily
HI843_RS03470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI843_RS03490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HI843_RS03495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HI843_RS03500	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HI843_RS03505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HI843_RS03510	COG3870	Protein conserved in bacteria
HI843_RS03515	COG0470	DNA polymerase III
HI843_RS03520	COG1774	PSP1 C-terminal conserved region
HI843_RS03525	COG4467	Involved in initiation control of chromosome replication
HI843_RS03540	COG0602	queuosine metabolic process
HI843_RS03545	COG1328	CTP reductase activity
HI843_RS03550	COG1136	(ABC) transporter
HI843_RS03555	COG0577	efflux transmembrane transporter activity
HI843_RS03565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HI843_RS03570	COG1696	Membrane protein involved in D-alanine export
HI843_RS03575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HI843_RS03580	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HI843_RS03585	COG1363	Peptidase, m42
HI843_RS03595	COG1234	tRNA 3'-trailer cleavage
HI843_RS03600	COG0095	Lipoate-protein ligase
HI843_RS03625	COG3759	membrane
HI843_RS03630	COG0659	secondary active sulfate transmembrane transporter activity
HI843_RS03640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HI843_RS03650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HI843_RS03655	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HI843_RS03655	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HI843_RS03660	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS03660	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS03670	COG3715	PTS system
HI843_RS03675	COG3716	PTS system mannose fructose sorbose family IID component
HI843_RS03685	COG2261	transglycosylase associated protein
HI843_RS03690	COG0006	proline dipeptidase activity
HI843_RS03695	COG1302	Protein conserved in bacteria
HI843_RS03700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HI843_RS03705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HI843_RS03710	COG1570	exodeoxyribonuclease VII activity
HI843_RS03715	COG1722	exodeoxyribonuclease VII activity
HI843_RS03725	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HI843_RS03730	COG1438	arginine binding
HI843_RS03735	COG0497	DNA recombination
HI843_RS03770	COG0768	penicillin binding
HI843_RS03805	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HI843_RS03810	COG1799	cell septum assembly
HI843_RS03820	COG2302	S4 RNA-binding domain
HI843_RS03825	COG3599	regulation of cell shape
HI843_RS03830	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HI843_RS03835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HI843_RS03855	COG0673	inositol 2-dehydrogenase activity
HI843_RS03860	COG0513	Belongs to the DEAD box helicase family
HI843_RS03865	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HI843_RS03865	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HI843_RS03870	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS03875	COG1447	Phosphotransferase system cellobiose-specific component IIA
HI843_RS03880	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS03940	COG1396	sequence-specific DNA binding
HI843_RS04095	COG0740	serine-type endopeptidase activity
HI843_RS04230	COG2309	aminopeptidase activity
HI843_RS04240	COG0716	FMN binding
HI843_RS04245	COG0024	Methionine aminopeptidase
HI843_RS04250	COG1295	ribonuclease BN
HI843_RS04255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HI843_RS04270	COG1215	transferase activity, transferring glycosyl groups
HI843_RS04275	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HI843_RS04285	COG1088	dTDP-glucose 4,6-dehydratase activity
HI843_RS04290	COG1091	dTDP-4-dehydrorhamnose reductase activity
HI843_RS04305	COG1682	transport, permease protein
HI843_RS04315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HI843_RS04320	COG0438	transferase activity, transferring glycosyl groups
HI843_RS04320	COG1216	Glycosyl transferase, family 2
HI843_RS04330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HI843_RS04335	COG1216	Glycosyl transferase, family 2
HI843_RS04340	COG3475	LICD family
HI843_RS04355	COG1216	Glycosyl transferase, family 2
HI843_RS04360	COG1216	Glycosyl transferase, family 2
HI843_RS04360	COG1442	glycosyl transferase family 8
HI843_RS04370	COG0438	transferase activity, transferring glycosyl groups
HI843_RS04390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HI843_RS04395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HI843_RS04405	COG4585	Histidine kinase
HI843_RS04415	COG0569	domain protein
HI843_RS04440	COG2246	polysaccharide biosynthetic process
HI843_RS04445	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HI843_RS04455	COG1316	TRANSCRIPTIONal
HI843_RS04460	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HI843_RS04465	COG3397	chitin binding
HI843_RS04470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HI843_RS04475	COG2137	regulation of response to DNA damage stimulus
HI843_RS04480	COG1194	a g-specific adenine glycosylase
HI843_RS04485	COG3557	Belongs to the UPF0374 family
HI843_RS04495	COG0628	permease
HI843_RS04500	COG1253	flavin adenine dinucleotide binding
HI843_RS04505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HI843_RS04520	COG0542	response to heat
HI843_RS04525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS04530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HI843_RS04540	COG0438	transferase activity, transferring glycosyl groups
HI843_RS04545	COG2084	Dehydrogenase
HI843_RS04550	COG4703	Protein of unknown function (DUF1797)
HI843_RS04555	COG0322	excinuclease ABC activity
HI843_RS04560	COG1846	Transcriptional regulator
HI843_RS04565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HI843_RS04575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HI843_RS04585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HI843_RS04595	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HI843_RS04600	COG0439	Biotin carboxylase
HI843_RS04605	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HI843_RS04610	COG0825	malonyl-CoA metabolic process
HI843_RS04615	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HI843_RS04620	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HI843_RS04625	COG1534	Rna-binding protein
HI843_RS04630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HI843_RS04635	COG1713	HD superfamily hydrolase involved in NAD metabolism
HI843_RS04640	COG0799	negative regulation of ribosome biogenesis
HI843_RS04645	COG2226	methyltransferase
HI843_RS04650	COG1323	Belongs to the UPF0348 family
HI843_RS04655	COG0217	transcriptional regulatory protein
HI843_RS04665	COG3973	AAA domain
HI843_RS04670	COG2217	Heavy metal translocating P-type atpase
HI843_RS04675	COG1942	4-Oxalocrotonate Tautomerase
HI843_RS04680	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HI843_RS04685	COG1737	Transcriptional regulator
HI843_RS04690	COG0768	penicillin binding
HI843_RS04700	COG0561	phosphatase activity
HI843_RS04705	COG2252	PERMEase
HI843_RS04710	COG2814	Major facilitator Superfamily
HI843_RS04720	COG0587	DNA-directed DNA polymerase activity
HI843_RS04725	COG0205	6-phosphofructokinase activity
HI843_RS04735	COG0583	DNA-binding transcription factor activity
HI843_RS04745	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HI843_RS04750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HI843_RS04755	COG0745	RESPONSE REGULATOR receiver
HI843_RS04760	COG5002	protein histidine kinase activity
HI843_RS04865	COG3711	transcriptional antiterminator
HI843_RS04875	COG1263	PTS System
HI843_RS04875	COG2190	(PTS) system
HI843_RS04875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS04895	COG2190	(PTS) system
HI843_RS04895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS04895	COG1263	PTS System
HI843_RS04900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS04920	COG1349	DNA-binding transcription factor activity
HI843_RS04945	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HI843_RS04950	COG3623	hexulose-6-phosphate isomerase
HI843_RS04960	COG0456	acetyltransferase
HI843_RS04980	COG3711	transcriptional antiterminator
HI843_RS05015	COG3964	amidohydrolase
HI843_RS05030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI843_RS05030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS05030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI843_RS05035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS05035	COG3711	transcriptional antiterminator
HI843_RS05040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HI843_RS05045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HI843_RS05050	COG0789	Transcriptional regulator
HI843_RS05060	COG1105	Belongs to the carbohydrate kinase PfkB family
HI843_RS05065	COG1349	DNA-binding transcription factor activity
HI843_RS05070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS05085	COG3775	system Galactitol-specific IIC component
HI843_RS05100	COG0400	carboxylic ester hydrolase activity
HI843_RS05105	COG0346	lactoylglutathione lyase activity
HI843_RS05110	COG2188	Transcriptional regulator
HI843_RS05115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS05120	COG2723	6-phospho-beta-galactosidase activity
HI843_RS05125	COG0589	response to stress
HI843_RS05140	COG1393	Belongs to the ArsC family
HI843_RS05150	COG0351	phosphomethylpyrimidine kinase
HI843_RS05155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HI843_RS05160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI843_RS05170	COG3425	synthase
HI843_RS05175	COG0183	Belongs to the thiolase family
HI843_RS05190	COG0656	L-ascorbic acid biosynthetic process
HI843_RS05210	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HI843_RS05210	COG0392	lysyltransferase activity
HI843_RS05215	COG0596	Alpha beta hydrolase
HI843_RS05220	COG0741	lytic transglycosylase activity
HI843_RS05230	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI843_RS05235	COG0358	DNA primase activity
HI843_RS05240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HI843_RS05250	COG2996	Protein conserved in bacteria
HI843_RS05255	COG0735	belongs to the Fur family
HI843_RS05260	COG4974	Belongs to the 'phage' integrase family
HI843_RS05270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HI843_RS05275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HI843_RS05280	COG1187	pseudouridine synthase activity
HI843_RS05285	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HI843_RS05290	COG1288	antiporter activity
HI843_RS05295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HI843_RS05315	COG0514	ATP-dependent DNA helicase (RecQ)
HI843_RS05325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HI843_RS05330	COG0539	negative regulation of cytoplasmic translation
HI843_RS05335	COG1160	GTP binding
HI843_RS05340	COG0776	regulation of translation
HI843_RS05350	COG0457	Tetratricopeptide repeat
HI843_RS05355	COG5582	Belongs to the UPF0302 family
HI843_RS05360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI843_RS05365	COG1694	Mazg nucleotide pyrophosphohydrolase
HI843_RS05370	COG0617	tRNA 3'-terminal CCA addition
HI843_RS05385	COG0025	NhaP-type Na H and K H
HI843_RS05390	COG0488	(ABC) transporter
HI843_RS05395	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HI843_RS05405	COG1272	protein, Hemolysin III
HI843_RS05410	COG1307	EDD domain protein, DegV family
HI843_RS05415	COG2755	lipolytic protein G-D-S-L family
HI843_RS05420	COG4698	Protein conserved in bacteria
HI843_RS05430	COG4479	Belongs to the UPF0346 family
HI843_RS05435	COG0681	Belongs to the peptidase S26 family
HI843_RS05455	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HI843_RS05460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HI843_RS05465	COG0758	DNA mediated transformation
HI843_RS05470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HI843_RS05475	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HI843_RS05480	COG4974	Belongs to the 'phage' integrase family
HI843_RS05485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HI843_RS05490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HI843_RS05505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HI843_RS05510	COG1832	CoA-binding protein
HI843_RS05515	COG0187	DNA topoisomerase II activity
HI843_RS05525	COG1882	Formate acetyltransferase
HI843_RS05530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HI843_RS05535	COG1227	inorganic diphosphatase activity
HI843_RS05555	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HI843_RS05565	COG1073	alpha beta
HI843_RS05570	COG1609	Transcriptional regulator
HI843_RS05580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI843_RS05590	COG1732	Glycine betaine
HI843_RS05605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HI843_RS05615	COG1116	anion transmembrane transporter activity
HI843_RS05620	COG0084	hydrolase, TatD family'
HI843_RS05625	COG1388	LysM domain
HI843_RS05625	COG3942	CHAP domain
HI843_RS05645	COG3328	transposase activity
HI843_RS05665	COG0436	Aminotransferase
HI843_RS05685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HI843_RS05690	COG4565	transcriptional regulatory protein
HI843_RS05695	COG3290	protein histidine kinase activity
HI843_RS05700	COG3290	protein histidine kinase activity
HI843_RS05710	COG2268	Band 7 protein
HI843_RS05725	COG0673	inositol 2-dehydrogenase activity
HI843_RS05735	COG1876	peptidase activity
HI843_RS05740	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI843_RS05740	COG1388	LysM domain
HI843_RS05750	COG1653	transport
HI843_RS05755	COG1175	transmembrane transport
HI843_RS05760	COG0395	ABC-type sugar transport system, permease component
HI843_RS05770	COG0673	inositol 2-dehydrogenase activity
HI843_RS05775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HI843_RS05780	COG2233	PERMEase
HI843_RS05785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HI843_RS05790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HI843_RS05795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HI843_RS05805	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HI843_RS05810	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HI843_RS05815	COG0047	phosphoribosylformylglycinamidine synthase activity
HI843_RS05820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HI843_RS05830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HI843_RS05835	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HI843_RS05840	COG0138	bifunctional purine biosynthesis protein purh
HI843_RS05845	COG0151	Belongs to the GarS family
HI843_RS05850	COG4989	oxidoreductase activity
HI843_RS05860	COG2972	Histidine kinase
HI843_RS05870	COG4213	ABC transporter substrate-binding protein
HI843_RS05880	COG4214	carbohydrate transport
HI843_RS05885	COG0516	GMP reductase activity
HI843_RS05890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HI843_RS05900	COG0022	dehydrogenase e1 component
HI843_RS05915	COG4476	Belongs to the UPF0223 family
HI843_RS05920	COG0483	inositol monophosphate 1-phosphatase activity
HI843_RS05930	COG0514	ATP-dependent DNA helicase (RecQ)
HI843_RS05935	COG4838	Belongs to the UPF0358 family
HI843_RS05940	COG0772	Belongs to the SEDS family
HI843_RS05945	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HI843_RS05960	COG4471	UPF0298 protein
HI843_RS05965	COG0742	ribosomal rna small subunit methyltransferase
HI843_RS05970	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HI843_RS05975	COG3480	Lon protease (S16) C-terminal proteolytic domain
HI843_RS05980	COG1555	photosystem II stabilization
HI843_RS05980	COG1596	polysaccharide export
HI843_RS05995	COG2131	deaminase
HI843_RS06000	COG0658	competence protein
HI843_RS06000	COG2333	competence protein COMEC
HI843_RS06005	COG1466	dna polymerase III delta subunit
HI843_RS06010	COG0268	Binds directly to 16S ribosomal RNA
HI843_RS06020	COG2707	UPF0756 membrane protein
HI843_RS06025	COG2217	Heavy metal translocating P-type atpase
HI843_RS06030	COG1968	undecaprenyl-diphosphatase activity
HI843_RS06050	COG1666	GTP binding
HI843_RS06055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI843_RS06060	COG2151	metal-sulfur cluster biosynthetic enzyme
HI843_RS06075	COG3942	CHAP domain
HI843_RS06075	COG1388	LysM domain
HI843_RS06130	COG4990	cell redox homeostasis
HI843_RS06150	COG3104	oligopeptide transport
HI843_RS06160	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HI843_RS06165	COG1074	ATP-dependent DNA helicase activity
HI843_RS06170	COG1733	regulation of RNA biosynthetic process
HI843_RS06175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HI843_RS06180	COG0072	phenylalanine-tRNA ligase activity
HI843_RS06180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI843_RS06190	COG1126	abc transporter atp-binding protein
HI843_RS06195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI843_RS06200	COG0765	amino acid transport
HI843_RS06205	COG0765	amino acid transport
HI843_RS06210	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HI843_RS06215	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HI843_RS06225	COG0517	IMP dehydrogenase activity
HI843_RS06230	COG0668	transmembrane transport
HI843_RS06235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HI843_RS06240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HI843_RS06245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HI843_RS06275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HI843_RS06285	COG1234	tRNA 3'-trailer cleavage
HI843_RS06290	COG0300	oxidoreductase activity
HI843_RS06295	COG5416	Lipopolysaccharide assembly protein A domain
HI843_RS06300	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HI843_RS06300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HI843_RS06305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HI843_RS06315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HI843_RS06345	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HI843_RS06350	COG0735	belongs to the Fur family
HI843_RS06355	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI843_RS06365	COG1846	Transcriptional regulator
HI843_RS06375	COG3935	DnaD domain protein
HI843_RS06380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HI843_RS06390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HI843_RS06395	COG3331	DNA recombination
HI843_RS06400	COG4474	Belongs to the UPF0398 family
HI843_RS06405	COG3599	regulation of cell shape
HI843_RS06415	COG0116	Belongs to the methyltransferase superfamily
HI843_RS06420	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HI843_RS06425	COG1418	mRNA catabolic process
HI843_RS06430	COG0156	8-amino-7-oxononanoate synthase activity
HI843_RS06435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HI843_RS06440	COG0531	amino acid
HI843_RS06455	COG0513	Belongs to the DEAD box helicase family
HI843_RS06460	COG2153	protein acetylation
HI843_RS06465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HI843_RS06470	COG4684	Psort location CytoplasmicMembrane, score
HI843_RS06480	COG0328	RNA-DNA hybrid ribonuclease activity
HI843_RS06490	COG1278	Cold shock
HI843_RS06495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HI843_RS06510	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HI843_RS06515	COG0564	pseudouridine synthase activity
HI843_RS06525	COG2233	PERMEase
HI843_RS06530	COG0540	Belongs to the ATCase OTCase family
HI843_RS06535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HI843_RS06540	COG0505	Belongs to the CarA family
HI843_RS06545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HI843_RS06550	COG0543	2 iron, 2 sulfur cluster binding
HI843_RS06560	COG0284	orotidine-5'-phosphate decarboxylase activity
HI843_RS06590	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HI843_RS06605	COG4120	Belongs to the binding-protein-dependent transport system permease family
HI843_RS06615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HI843_RS06650	COG0039	L-malate dehydrogenase activity
HI843_RS06670	COG3037	sugar-specific permease SgaT UlaA
HI843_RS06680	COG3711	transcriptional antiterminator
HI843_RS06690	COG0673	inositol 2-dehydrogenase activity
HI843_RS06740	COG0745	RESPONSE REGULATOR receiver
HI843_RS06745	COG5002	protein histidine kinase activity
HI843_RS06750	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HI843_RS06775	COG0351	phosphomethylpyrimidine kinase
HI843_RS06785	COG4475	Protein of unknown function (DUF436)
HI843_RS06790	COG0366	Alpha amylase catalytic
HI843_RS06805	COG1307	EDD domain protein, DegV family
HI843_RS06810	COG2244	polysaccharide biosynthetic process
HI843_RS06860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HI843_RS06865	COG0194	GDP metabolic process
HI843_RS06885	COG0765	amino acid transport
HI843_RS06890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI843_RS06900	COG0167	dihydroorotate dehydrogenase activity
HI843_RS06910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HI843_RS06920	COG3833	ABC-type maltose transport systems, permease component
HI843_RS06925	COG1175	transmembrane transport
HI843_RS06930	COG2182	Extracellular solute-binding protein
HI843_RS06935	COG0366	Alpha amylase catalytic
HI843_RS06940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI843_RS06950	COG1764	response to oxidative stress
HI843_RS06955	COG1846	Transcriptional regulator
HI843_RS06960	COG0628	permease
HI843_RS06975	COG1312	Catalyzes the dehydration of D-mannonate
HI843_RS06990	COG0450	alkyl hydroperoxide reductase
HI843_RS07040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HI843_RS07055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HI843_RS07070	COG0531	amino acid
HI843_RS07075	COG0004	ammonium transporteR
HI843_RS07080	COG2261	transglycosylase associated protein
HI843_RS07120	COG3655	Transcriptional regulator
HI843_RS07130	COG2261	transglycosylase associated protein
HI843_RS07150	COG1028	Short-chain dehydrogenase reductase Sdr
HI843_RS07165	COG1442	glycosyl transferase family 8
HI843_RS07170	COG1442	glycosyl transferase family 8
HI843_RS07175	COG0561	phosphatase activity
HI843_RS07200	COG1476	TRANSCRIPTIONal
HI843_RS07225	COG1278	Cold shock
HI843_RS07235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI843_RS07240	COG1312	Catalyzes the dehydration of D-mannonate
HI843_RS07260	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS07265	COG3716	PTS system mannose fructose sorbose family IID component
HI843_RS07275	COG0371	Dehydrogenase
HI843_RS07290	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HI843_RS07295	COG1737	Transcriptional regulator
HI843_RS07295	COG0837	glucose binding
HI843_RS07305	COG2272	Belongs to the type-B carboxylesterase lipase family
HI843_RS07310	COG1073	alpha beta
HI843_RS07345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HI843_RS07365	COG3732	PTS system glucitol sorbitol-specific
HI843_RS07370	COG3730	PTS system glucitol sorbitol-specific
HI843_RS07380	COG3711	transcriptional antiterminator
HI843_RS07380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS07405	COG3328	transposase activity
HI843_RS07415	COG4974	Belongs to the 'phage' integrase family
HI843_RS07420	COG0582	viral genome integration into host DNA
HI843_RS07440	COG3250	beta-galactosidase activity
HI843_RS07455	COG2211	Major facilitator Superfamily
HI843_RS07465	COG1904	glucuronate isomerase
HI843_RS07470	COG1312	Catalyzes the dehydration of D-mannonate
HI843_RS07525	COG0433	COG0433 Predicted ATPase
HI843_RS07570	COG2946	Replication initiation factor
HI843_RS07580	COG1674	ftsk spoiiie
HI843_RS07620	COG0481	GTPase activity
HI843_RS07640	COG0542	response to heat
HI843_RS07655	COG1597	lipid kinase activity
HI843_RS07660	COG2195	Cleaves the N-terminal amino acid of tripeptides
HI843_RS07665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HI843_RS07670	COG2384	SAM-dependent methyltransferase
HI843_RS07680	COG1484	DNA-dependent DNA replication
HI843_RS07690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HI843_RS07700	COG0237	dephospho-CoA kinase activity
HI843_RS07705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HI843_RS07710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HI843_RS07710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HI843_RS07725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HI843_RS07730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HI843_RS07735	COG3091	SprT-like family
HI843_RS07740	COG2183	response to ionizing radiation
HI843_RS07770	COG0546	phosphoglycolate phosphatase activity
HI843_RS07775	COG0588	phosphoglycerate mutase activity
HI843_RS07830	COG2207	Transcriptional regulator
HI843_RS07830	COG4753	response regulator
HI843_RS07840	COG2972	Histidine kinase
HI843_RS07845	COG0077	Prephenate dehydratase
HI843_RS07850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HI843_RS07855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HI843_RS07860	COG0287	Prephenate dehydrogenase
HI843_RS07865	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HI843_RS07875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HI843_RS07880	COG3250	beta-galactosidase activity
HI843_RS07895	COG1609	Transcriptional regulator
HI843_RS07905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HI843_RS07915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HI843_RS07920	COG1597	lipid kinase activity
HI843_RS07925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HI843_RS07930	COG0154	amidase activity
HI843_RS07935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HI843_RS07940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HI843_RS07945	COG0210	DNA helicase
HI843_RS07955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI843_RS07955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI843_RS07955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS07960	COG1105	Belongs to the carbohydrate kinase PfkB family
HI843_RS07965	COG1349	DNA-binding transcription factor activity
HI843_RS07985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HI843_RS07990	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HI843_RS07995	COG0544	peptidyl-prolyl cis-trans isomerase activity
HI843_RS08005	COG1714	RDD family
HI843_RS08020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HI843_RS08025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HI843_RS08060	COG1481	regulation of sporulation
HI843_RS08065	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HI843_RS08070	COG1660	Displays ATPase and GTPase activities
HI843_RS08085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HI843_RS08090	COG0556	nucleotide-excision repair
HI843_RS08095	COG0765	amino acid transport
HI843_RS08100	COG1126	abc transporter atp-binding protein
HI843_RS08105	COG0484	heat shock protein binding
HI843_RS08110	COG0443	Heat shock 70 kDa protein
HI843_RS08115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HI843_RS08120	COG1420	regulation of RNA biosynthetic process
HI843_RS08125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HI843_RS08155	COG0693	protein deglycase activity
HI843_RS08170	COG1619	proteins homologs of microcin C7 resistance protein MccF
HI843_RS08180	COG5646	InterPro IPR014922
HI843_RS08190	COG4975	Glucose uptake
HI843_RS08200	COG0196	riboflavin kinase activity
HI843_RS08205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HI843_RS08215	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HI843_RS08220	COG1175	transmembrane transport
HI843_RS08225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HI843_RS08240	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HI843_RS08245	COG0195	Participates in both transcription termination and antitermination
HI843_RS08250	COG0779	Required for maturation of 30S ribosomal subunits
HI843_RS08255	COG2176	DNA-directed DNA polymerase activity
HI843_RS08260	COG0442	prolyl-tRNA aminoacylation
HI843_RS08265	COG0750	zinc metalloprotease
HI843_RS08270	COG4589	Belongs to the CDS family
HI843_RS08275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HI843_RS08280	COG0233	cytoplasmic translational termination
HI843_RS08285	COG0528	UMP kinase activity
HI843_RS08290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HI843_RS08295	COG0052	Belongs to the universal ribosomal protein uS2 family
HI843_RS08300	COG1438	arginine binding
HI843_RS08310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI843_RS08315	COG0018	arginyl-trna synthetase
HI843_RS08330	COG2235	arginine
HI843_RS08335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI843_RS08340	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HI843_RS08345	COG0456	acetyltransferase
HI843_RS08355	COG1214	PFAM Peptidase M22, glycoprotease
HI843_RS08360	COG1609	Transcriptional regulator
HI843_RS08365	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HI843_RS08370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HI843_RS08385	COG3189	MarR family transcriptional regulator
HI843_RS08390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HI843_RS08395	COG1940	carbohydrate kinase activity
HI843_RS08410	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HI843_RS08415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HI843_RS08420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HI843_RS08425	COG1120	ATPase activity
HI843_RS08440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HI843_RS08445	COG4876	unkown
HI843_RS08450	COG0367	asparagine synthase
HI843_RS08455	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HI843_RS08465	COG1309	transcriptional regulator
HI843_RS08485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HI843_RS08500	COG0584	glycerophosphoryl diester phosphodiesterase
HI843_RS08520	COG0166	Belongs to the GPI family
HI843_RS08525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HI843_RS08530	COG2081	HI0933 family
HI843_RS08535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HI843_RS08540	COG0710	3-dehydroquinate dehydratase activity
HI843_RS08545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HI843_RS08550	COG1368	sulfuric ester hydrolase activity
HI843_RS08575	COG5002	protein histidine kinase activity
HI843_RS08575	COG3850	Histidine kinase
HI843_RS08580	COG0745	RESPONSE REGULATOR receiver
HI843_RS08600	COG2826	transposase and inactivated derivatives, IS30 family
HI843_RS08620	COG1956	GAF domain-containing protein
HI843_RS08625	COG3527	Alpha-acetolactate decarboxylase
HI843_RS08630	COG0028	Belongs to the TPP enzyme family
HI843_RS08640	COG0395	ABC-type sugar transport system, permease component
HI843_RS08650	COG0583	DNA-binding transcription factor activity
HI843_RS08655	COG0789	Transcriptional regulator
HI843_RS08660	COG2814	Major facilitator Superfamily
HI843_RS08830	COG0740	serine-type endopeptidase activity
HI843_RS09005	COG1396	sequence-specific DNA binding
HI843_RS09025	COG0582	viral genome integration into host DNA
HI843_RS09030	COG0335	large ribosomal subunit rRNA binding
HI843_RS09035	COG0336	Belongs to the RNA methyltransferase TrmD family
HI843_RS09040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HI843_RS09050	COG1837	Belongs to the UPF0109 family
HI843_RS09055	COG0228	four-way junction DNA binding
HI843_RS09060	COG0431	NADPH-dependent FMN reductase
HI843_RS09065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HI843_RS09070	COG0519	Catalyzes the synthesis of GMP from XMP
HI843_RS09075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HI843_RS09080	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HI843_RS09090	COG0745	RESPONSE REGULATOR receiver
HI843_RS09095	COG5002	protein histidine kinase activity
HI843_RS09100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI843_RS09110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HI843_RS09135	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HI843_RS09155	COG3328	transposase activity
HI843_RS09195	COG0714	Associated with various cellular activities
HI843_RS09210	COG2217	Heavy metal translocating P-type atpase
HI843_RS09215	COG2217	Heavy metal translocating P-type atpase
HI843_RS09220	COG2608	mercury ion transmembrane transporter activity
HI843_RS09225	COG3682	Transcriptional regulator
HI843_RS09235	COG0531	amino acid
HI843_RS09240	COG2217	Heavy metal translocating P-type atpase
HI843_RS09260	COG0017	Asparaginyl-tRNA synthetase
HI843_RS09265	COG0436	Aminotransferase
HI843_RS09275	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HI843_RS09275	COG1199	ATP-dependent helicase activity
HI843_RS09280	COG1278	Cold shock
HI843_RS09295	COG1686	Belongs to the peptidase S11 family
HI843_RS09305	COG0038	chloride channel
HI843_RS09320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HI843_RS09325	COG1254	Belongs to the acylphosphatase family
HI843_RS09330	COG0706	membrane insertase activity
HI843_RS09335	COG3684	Belongs to the aldolase LacD family
HI843_RS09340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS09340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS09340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HI843_RS09345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI843_RS09345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS09345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI843_RS09350	COG1105	Belongs to the carbohydrate kinase PfkB family
HI843_RS09365	COG4372	Transposase
HI843_RS09385	COG0438	transferase activity, transferring glycosyl groups
HI843_RS09385	COG0297	glycogen (starch) synthase activity
HI843_RS09395	COG1045	serine acetyltransferase
HI843_RS09405	COG0438	transferase activity, transferring glycosyl groups
HI843_RS09410	COG0438	transferase activity, transferring glycosyl groups
HI843_RS09420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HI843_RS09425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HI843_RS09435	COG4464	protein tyrosine phosphatase activity
HI843_RS09440	COG0489	protein tyrosine kinase activity
HI843_RS09445	COG3944	biosynthesis protein
HI843_RS09450	COG1316	TRANSCRIPTIONal
HI843_RS09470	COG0751	glycine-tRNA ligase activity
HI843_RS09475	COG0752	glycyl-tRNA synthetase alpha subunit
HI843_RS09480	COG1381	Involved in DNA repair and RecF pathway recombination
HI843_RS09485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HI843_RS09490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HI843_RS09495	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HI843_RS09505	COG1702	phosphate starvation-inducible protein PhoH
HI843_RS09510	COG1114	Component of the transport system for branched-chain amino acids
HI843_RS09515	COG1610	YqeY-like protein
HI843_RS09520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HI843_RS09525	COG0735	belongs to the Fur family
HI843_RS09530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HI843_RS09535	COG0640	Transcriptional regulator
HI843_RS09540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HI843_RS09545	COG0492	ferredoxin-NADP+ reductase activity
HI843_RS09550	COG2723	6-phospho-beta-galactosidase activity
HI843_RS09555	COG1486	melibiose metabolic process
HI843_RS09560	COG1737	Transcriptional regulator
HI843_RS09570	COG3711	transcriptional antiterminator
HI843_RS09575	COG1132	(ABC) transporter
HI843_RS09580	COG1132	(ABC) transporter
HI843_RS09585	COG3763	UPF0154 protein
HI843_RS09590	COG1914	H( )-stimulated, divalent metal cation uptake system
HI843_RS09600	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HI843_RS09610	COG1609	Transcriptional regulator
HI843_RS09620	COG4980	gas vesicle protein
HI843_RS09630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HI843_RS09635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HI843_RS09640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HI843_RS09645	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HI843_RS09650	COG1950	PFAM Membrane protein of
HI843_RS09675	COG0704	Plays a role in the regulation of phosphate uptake
HI843_RS09680	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HI843_RS09685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HI843_RS09690	COG0581	inorganic phosphate transmembrane transporter activity
HI843_RS09695	COG0573	inorganic phosphate transmembrane transporter activity
HI843_RS09700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HI843_RS09705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HI843_RS09710	COG2177	Part of the ABC transporter FtsEX involved in
HI843_RS09715	COG2884	Cell division ATP-binding protein ftsE
HI843_RS09725	COG0653	protein targeting
HI843_RS09740	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HI843_RS09745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS09755	COG1739	Uncharacterized protein family UPF0029
HI843_RS09760	COG2188	Transcriptional regulator
HI843_RS09785	COG1940	carbohydrate kinase activity
HI843_RS09805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HI843_RS09820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HI843_RS09825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HI843_RS09830	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HI843_RS09835	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HI843_RS09840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HI843_RS09845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HI843_RS09850	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HI843_RS09855	COG0356	it plays a direct role in the translocation of protons across the membrane
HI843_RS09870	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HI843_RS09875	COG2388	GCN5-related N-acetyl-transferase
HI843_RS09885	COG1957	nucleoside hydrolase
HI843_RS09910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HI843_RS09920	COG0149	triose-phosphate isomerase activity
HI843_RS09925	COG0126	phosphoglycerate kinase activity
HI843_RS09935	COG2390	Transcriptional regulator
HI843_RS09940	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HI843_RS09960	COG1595	DNA-templated transcription, initiation
HI843_RS09975	COG0095	Lipoate-protein ligase
HI843_RS09980	COG1078	dGTPase activity
HI843_RS09985	COG0561	phosphatase activity
HI843_RS09990	COG0494	nUDIX hydrolase
HI843_RS09995	COG0346	lactoylglutathione lyase activity
HI843_RS10005	COG2423	ornithine cyclodeaminase activity
HI843_RS10010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HI843_RS10015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HI843_RS10020	COG1394	ATPase activity, coupled to movement of substances
HI843_RS10025	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HI843_RS10030	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HI843_RS10035	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HI843_RS10040	COG1527	subunit (C
HI843_RS10045	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HI843_RS10050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HI843_RS10055	COG1269	ATP hydrolysis coupled proton transport
HI843_RS10065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HI843_RS10070	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HI843_RS10080	COG4152	abc transporter atp-binding protein
HI843_RS10085	COG0322	excinuclease ABC activity
HI843_RS10090	COG3118	belongs to the thioredoxin family
HI843_RS10095	COG1193	negative regulation of DNA recombination
HI843_RS10110	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HI843_RS10125	COG1136	(ABC) transporter
HI843_RS10135	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI843_RS10165	COG1304	FMN binding
HI843_RS10175	COG0281	malic enzyme
HI843_RS10215	COG4695	Portal protein
HI843_RS10295	COG4974	Belongs to the 'phage' integrase family
HI843_RS10300	COG3906	Belongs to the UPF0473 family
HI843_RS10305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HI843_RS10310	COG4472	Bacterial protein of unknown function (DUF965)
HI843_RS10340	COG4555	ABC transporter
HI843_RS10350	COG3689	TIGRFAM TIGR03943 family protein
HI843_RS10355	COG0701	Predicted permease
HI843_RS10360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI843_RS10365	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HI843_RS10370	COG0488	(ABC) transporter
HI843_RS10375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HI843_RS10390	COG0395	ABC-type sugar transport system, permease component
HI843_RS10405	COG2207	Transcriptional regulator
HI843_RS10405	COG0662	Cupin 2, conserved barrel domain protein
HI843_RS10410	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI843_RS10420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HI843_RS10425	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HI843_RS10430	COG0584	glycerophosphoryl diester phosphodiesterase
HI843_RS10440	COG0740	serine-type endopeptidase activity
HI843_RS10445	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HI843_RS10455	COG1132	(ABC) transporter
HI843_RS10475	COG1278	Cold shock
HI843_RS10480	COG2003	Belongs to the UPF0758 family
HI843_RS10485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI843_RS10490	COG0285	dihydrofolate synthase activity
HI843_RS10495	COG0525	valine-tRNA ligase activity
HI843_RS10500	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HI843_RS10505	COG0301	tRNA thio-modification
HI843_RS10510	COG1104	cysteine desulfurase activity
HI843_RS10515	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HI843_RS10525	COG0561	phosphatase activity
HI843_RS10530	COG1801	Protein of unknown function DUF72
HI843_RS10550	COG3579	cysteine-type endopeptidase activity
HI843_RS10610	COG1098	S1 RNA binding domain
HI843_RS10615	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HI843_RS10625	COG0492	ferredoxin-NADP+ reductase activity
HI843_RS10630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HI843_RS10645	COG4470	Protein conserved in bacteria
HI843_RS10650	COG0737	Belongs to the 5'-nucleotidase family
HI843_RS10660	COG0590	tRNA wobble adenosine to inosine editing
HI843_RS10665	COG2508	Transcriptional regulator
HI843_RS10675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HI843_RS10675	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HI843_RS10690	COG2738	Putative neutral zinc metallopeptidase
HI843_RS10695	COG2824	Alkylphosphonate utilization operon protein PhnA
HI843_RS10700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HI843_RS10705	COG4109	DRTGG domain
HI843_RS10710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HI843_RS10725	COG0577	efflux transmembrane transporter activity
HI843_RS10730	COG1136	(ABC) transporter
HI843_RS10740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HI843_RS10745	COG1288	antiporter activity
HI843_RS10750	COG4821	SIS domain
HI843_RS10765	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HI843_RS10770	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HI843_RS10775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HI843_RS10780	COG3716	PTS system mannose fructose sorbose family IID component
HI843_RS10785	COG3715	PTS system
HI843_RS10810	COG1132	(ABC) transporter
HI843_RS10815	COG1132	(ABC) transporter
HI843_RS10825	COG1803	Methylglyoxal synthase
HI843_RS10830	COG3842	ATPase activity
HI843_RS10840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HI843_RS10845	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HI843_RS10850	COG0084	hydrolase, TatD family'
HI843_RS10855	COG0531	amino acid
HI843_RS10865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI843_RS10865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI843_RS10880	COG0675	Transposase, IS605 OrfB family
HI843_RS10885	COG4608	Belongs to the ABC transporter superfamily
HI843_RS10890	COG0444	Belongs to the ABC transporter superfamily
HI843_RS10895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HI843_RS10900	COG0601	transmembrane transport
HI843_RS10910	COG4166	transmembrane transport
HI843_RS10925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HI843_RS10930	COG1674	ftsk spoiiie
HI843_RS10930	COG1280	lysine exporter protein (LysE YggA)
HI843_RS10935	COG2723	6-phospho-beta-galactosidase activity
HI843_RS10940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI843_RS10945	COG1126	abc transporter atp-binding protein
HI843_RS10950	COG0765	amino acid transport
HI843_RS10990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HI843_RS11000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HI843_RS11005	COG0009	L-threonylcarbamoyladenylate synthase
HI843_RS11015	COG2890	protein-(glutamine-N5) methyltransferase activity
HI843_RS11020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HI843_RS11025	COG1435	thymidine kinase activity
HI843_RS11035	COG2226	methyltransferase
HI843_RS11040	COG0681	Belongs to the peptidase S26 family
HI843_RS11060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HI843_RS11065	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HI843_RS11070	COG3442	glutamine amidotransferase
HI843_RS11075	COG0246	Mannitol dehydrogenase
HI843_RS11080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS11085	COG2213	PTS system mannitol-specific
HI843_RS11090	COG1131	(ABC) transporter
HI843_RS11100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS11105	COG3711	transcriptional antiterminator
HI843_RS11110	COG2213	PTS system mannitol-specific
HI843_RS11115	COG1482	cell wall glycoprotein biosynthetic process
HI843_RS11130	COG1132	(ABC) transporter
HI843_RS11150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HI843_RS11155	COG0628	permease
HI843_RS11165	COG2706	6-phosphogluconolactonase activity
HI843_RS11180	COG1368	sulfuric ester hydrolase activity
HI843_RS11185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HI843_RS11190	COG2160	L-arabinose isomerase activity
HI843_RS11195	COG0235	Class ii aldolase
HI843_RS11215	COG3940	Belongs to the glycosyl hydrolase 43 family
HI843_RS11220	COG3534	alpha-L-arabinofuranosidase
HI843_RS11230	COG0395	ABC-type sugar transport system, permease component
HI843_RS11235	COG1175	transmembrane transport
HI843_RS11255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HI843_RS11260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HI843_RS11270	COG0789	Transcriptional regulator
HI843_RS11275	COG1609	Transcriptional regulator
HI843_RS11290	COG0459	protein refolding
HI843_RS11295	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HI843_RS11305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS11310	COG2910	NAD(P)H-binding
HI843_RS11315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HI843_RS11330	COG5002	protein histidine kinase activity
HI843_RS11335	COG0745	RESPONSE REGULATOR receiver
HI843_RS11340	COG1307	EDD domain protein, DegV family
HI843_RS11380	COG4175	Glycine betaine
HI843_RS11380	COG3448	diguanylate cyclase activity
HI843_RS11405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HI843_RS11410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HI843_RS11420	COG0628	permease
HI843_RS11425	COG1285	pathogenesis
HI843_RS11430	COG0363	glucosamine-6-phosphate deaminase activity
HI843_RS11435	COG0488	(ABC) transporter
HI843_RS11450	COG2814	Major facilitator Superfamily
HI843_RS11460	COG0222	ribosome binding
HI843_RS11465	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HI843_RS11470	COG0081	regulation of translation
HI843_RS11475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HI843_RS11480	COG1760	l-serine dehydratase
HI843_RS11485	COG1760	l-serine dehydratase
HI843_RS11490	COG1304	FMN binding
HI843_RS11495	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HI843_RS11500	COG0250	Participates in transcription elongation, termination and antitermination
HI843_RS11505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HI843_RS11510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HI843_RS11525	COG1597	lipid kinase activity
HI843_RS11540	COG1131	(ABC) transporter
HI843_RS11545	COG4585	Histidine kinase
HI843_RS11550	COG2197	response regulator
HI843_RS11560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HI843_RS11570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HI843_RS11575	COG2226	methyltransferase
HI843_RS11580	COG3142	Participates in the control of copper homeostasis
HI843_RS11585	COG2239	Acts as a magnesium transporter
HI843_RS11590	COG0564	pseudouridine synthase activity
HI843_RS11595	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HI843_RS11600	COG2357	RelA SpoT domain protein
HI843_RS11605	COG4116	CYTH
HI843_RS11630	COG4862	establishment of competence for transformation
HI843_RS11635	COG1393	Belongs to the ArsC family
HI843_RS11650	COG0419	ATPase involved in DNA repair
HI843_RS11655	COG0420	3'-5' exonuclease activity
HI843_RS11660	COG0204	Acyl-transferase
HI843_RS11665	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HI843_RS11670	COG2827	Endonuclease containing a URI domain
HI843_RS11675	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HI843_RS11675	COG2755	lipolytic protein G-D-S-L family
HI843_RS11680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI843_RS11685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HI843_RS11690	COG0124	histidyl-tRNA synthetase
HI843_RS11695	COG0667	Aldo Keto reductase
HI843_RS11700	COG2124	cytochrome p450
HI843_RS11705	COG1490	D-aminoacyl-tRNA deacylase activity
HI843_RS11710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HI843_RS11715	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HI843_RS11720	COG2264	protein methyltransferase activity
HI843_RS11730	COG2094	Belongs to the DNA glycosylase MPG family
HI843_RS11735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HI843_RS11750	COG0589	response to stress
HI843_RS11760	COG0488	(ABC) transporter
HI843_RS11765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HI843_RS11770	COG0827	DNA restriction-modification system
HI843_RS11795	COG4537	Required for transformation and DNA binding
HI843_RS11800	COG1459	type II secretion system
HI843_RS11805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HI843_RS11810	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HI843_RS11815	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HI843_RS11825	COG4473	ABC transporter
HI843_RS11830	COG1131	(ABC) transporter
HI843_RS11835	COG0537	adenosine 5'-monophosphoramidase activity
HI843_RS11845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HI843_RS11850	COG3481	metal-dependent phosphohydrolase, HD sub domain
HI843_RS11855	COG4717	serine-type aminopeptidase activity
HI843_RS11860	COG0420	3'-5' exonuclease activity
HI843_RS11865	COG0561	phosphatase activity
HI843_RS11890	COG2211	Major facilitator Superfamily
HI843_RS11895	COG3507	Belongs to the glycosyl hydrolase 43 family
HI843_RS11910	COG1073	alpha beta
HI843_RS11920	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HI843_RS11925	COG1653	transport
HI843_RS11935	COG4209	transmembrane transport
HI843_RS11940	COG0395	ABC-type sugar transport system, permease component
HI843_RS11945	COG2207	Transcriptional regulator
HI843_RS11950	COG1609	Transcriptional regulator
HI843_RS11955	COG0246	Mannitol dehydrogenase
HI843_RS11960	COG2721	sulfolactate sulfo-lyase activity
HI843_RS11965	COG1904	glucuronate isomerase
HI843_RS11970	COG2755	lipolytic protein G-D-S-L family
HI843_RS11980	COG1132	(ABC) transporter
HI843_RS11985	COG3679	Belongs to the UPF0342 family
HI843_RS11990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HI843_RS11995	COG0564	pseudouridine synthase activity
HI843_RS12000	COG1940	carbohydrate kinase activity
HI843_RS12005	COG0383	alpha-mannosidase activity
HI843_RS12025	COG2207	Transcriptional regulator
HI843_RS12025	COG4753	response regulator
HI843_RS12030	COG2972	Histidine kinase
HI843_RS12045	COG0395	ABC-type sugar transport system, permease component
HI843_RS12050	COG1175	transmembrane transport
HI843_RS12055	COG1187	pseudouridine synthase activity
HI843_RS12060	COG2244	polysaccharide biosynthetic process
HI843_RS12070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HI843_RS12075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS12090	COG3711	transcriptional antiterminator
HI843_RS12090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI843_RS12140	COG4978	Transcriptional regulator
HI843_RS12140	COG0789	Transcriptional regulator
HI843_RS12150	COG1132	(ABC) transporter
HI843_RS12160	COG0495	leucyl-tRNA aminoacylation
HI843_RS12165	COG1388	LysM domain
HI843_RS12165	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI843_RS12170	COG0671	phosphoesterase, PA-phosphatase related
HI843_RS12175	COG1242	4 iron, 4 sulfur cluster binding
HI843_RS12180	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HI843_RS12185	COG1132	(ABC) transporter
HI843_RS12190	COG1132	(ABC) transporter
HI843_RS12205	COG0477	Major facilitator Superfamily
HI843_RS12210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HI843_RS12360	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HI843_RS12365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HI843_RS12370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HI843_RS12385	COG0037	tRNA processing
HI843_RS12390	COG1098	S1 RNA binding domain
HI843_RS12400	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HI843_RS12405	COG2244	polysaccharide biosynthetic process
HI843_RS12410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HI843_RS12415	COG0193	aminoacyl-tRNA hydrolase activity
HI843_RS12420	COG0039	L-malate dehydrogenase activity
HI843_RS12430	COG0217	transcriptional regulatory protein
HI843_RS12455	COG1792	Involved in formation and maintenance of cell shape
HI843_RS12465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HI843_RS12470	COG1162	GTPase activity
HI843_RS12475	COG0515	serine threonine protein kinase
HI843_RS12475	COG2815	serine threonine protein kinase
HI843_RS12480	COG0631	protein serine/threonine phosphatase activity
HI843_RS12485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HI843_RS12485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HI843_RS12490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HI843_RS12495	COG0242	peptide deformylase activity
HI843_RS12500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HI843_RS12505	COG1758	RNA polymerase activity
HI843_RS12510	COG0194	GDP metabolic process
HI843_RS12520	COG1561	YicC-like family, N-terminal region
HI843_RS12530	COG1752	Esterase of the alpha-beta hydrolase superfamily
HI843_RS12545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HI843_RS12550	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HI843_RS12555	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HI843_RS12560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HI843_RS12565	COG1121	(ABC) transporter
HI843_RS12570	COG0803	Belongs to the bacterial solute-binding protein 9 family
HI843_RS12570	COG3443	Belongs to the bacterial solute-binding protein 9 family
HI843_RS12575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HI843_RS12580	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HI843_RS12580	COG0392	lysyltransferase activity
HI843_RS12585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HI843_RS12590	COG1418	mRNA catabolic process
HI843_RS12595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HI843_RS12600	COG1058	Belongs to the CinA family
HI843_RS12600	COG1546	Belongs to the CinA family
HI843_RS12605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HI843_RS12610	COG1426	Protein conserved in bacteria
HI843_RS12615	COG0612	Peptidase, M16
HI843_RS12620	COG0612	Peptidase, M16
HI843_RS12625	COG1970	mechanosensitive ion channel activity
HI843_RS12630	COG2153	protein acetylation
HI843_RS12635	COG4466	Protein conserved in bacteria
HI843_RS12645	COG3688	RNA-binding protein containing a PIN domain
HI843_RS12650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HI843_RS12655	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HI843_RS12660	COG0215	cysteine-tRNA ligase activity
HI843_RS12665	COG1045	serine acetyltransferase
HI843_RS12670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HI843_RS12675	COG4956	integral membrane protein (PIN domain superfamily)
HI843_RS12685	COG0756	dUTP diphosphatase activity
HI843_RS12690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HI843_RS12695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HI843_RS12730	COG0778	Nitroreductase
HI843_RS12745	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI843_RS12745	COG1388	LysM domain
HI843_RS12750	COG4221	oxidoreductase activity
HI843_RS12760	COG0583	DNA-binding transcription factor activity
HI843_RS12765	COG3711	transcriptional antiterminator
HI843_RS12770	COG1263	PTS System
HI843_RS12770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS12770	COG2190	(PTS) system
HI843_RS12775	COG0702	epimerase
HI843_RS12790	COG2207	Transcriptional regulator
HI843_RS12790	COG3708	Transcriptional regulator
HI843_RS12805	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HI843_RS12815	COG0604	alcohol dehydrogenase
HI843_RS12820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HI843_RS12825	COG0842	Transport permease protein
HI843_RS12830	COG1131	(ABC) transporter
HI843_RS12840	COG2205	protein histidine kinase activity
HI843_RS12845	COG0745	RESPONSE REGULATOR receiver
HI843_RS12885	COG1674	ftsk spoiiie
HI843_RS12895	COG1674	ftsk spoiiie
HI843_RS12910	COG2946	Replication initiation factor
HI843_RS12965	COG0791	NLP P60 protein
HI843_RS12965	COG0741	lytic transglycosylase activity
HI843_RS13000	COG3942	CHAP domain
HI843_RS13000	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI843_RS13005	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI843_RS13020	COG3708	Transcriptional regulator
HI843_RS13020	COG2207	Transcriptional regulator
HI843_RS13080	COG3443	Belongs to the bacterial solute-binding protein 9 family
HI843_RS13080	COG0803	Belongs to the bacterial solute-binding protein 9 family
HI843_RS13095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HI843_RS13105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HI843_RS13110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HI843_RS13115	COG1132	(ABC) transporter
HI843_RS13120	COG1132	(ABC) transporter
HI843_RS13130	COG1129	ABC transporter
HI843_RS13140	COG1309	transcriptional regulator
HI843_RS13170	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HI843_RS13175	COG1082	Xylose isomerase domain protein TIM barrel
HI843_RS13180	COG0673	inositol 2-dehydrogenase activity
HI843_RS13195	COG1012	belongs to the aldehyde dehydrogenase family
HI843_RS13200	COG3718	enzyme involved in inositol metabolism
HI843_RS13205	COG3962	Belongs to the TPP enzyme family
HI843_RS13210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HI843_RS13215	COG1609	Transcriptional regulator
HI843_RS13240	COG1378	Sugar-specific transcriptional regulator TrmB
HI843_RS13270	COG4974	Belongs to the 'phage' integrase family
HI843_RS13275	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HI843_RS13280	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HI843_RS13285	COG0783	Belongs to the Dps family
HI843_RS13290	COG1070	Carbohydrate kinase
HI843_RS13295	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HI843_RS13300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HI843_RS13305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI843_RS13315	COG1554	hydrolase, family 65, central catalytic
HI843_RS13320	COG0673	inositol 2-dehydrogenase activity
HI843_RS13325	COG1082	Xylose isomerase domain protein TIM barrel
HI843_RS13330	COG1063	alcohol dehydrogenase
HI843_RS13335	COG0395	ABC-type sugar transport system, permease component
HI843_RS13340	COG1175	transmembrane transport
HI843_RS13345	COG1653	transport
HI843_RS13350	COG0366	Alpha amylase catalytic
HI843_RS13355	COG1609	Transcriptional regulator
HI843_RS13360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HI843_RS13365	COG0085	RNA polymerase activity
HI843_RS13375	COG4120	Belongs to the binding-protein-dependent transport system permease family
HI843_RS13385	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HI843_RS13385	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HI843_RS13400	COG0142	geranyltranstransferase activity
HI843_RS13420	COG4939	FMN-binding domain protein
HI843_RS13435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HI843_RS13450	COG0542	response to heat
HI843_RS13455	COG4463	regulation of RNA biosynthetic process
HI843_RS13530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HI843_RS13535	COG0516	GMP reductase activity
HI843_RS13535	COG0517	IMP dehydrogenase activity
HI843_RS13545	COG0012	GTP binding
HI843_RS13550	COG4481	Protein conserved in bacteria
HI843_RS13555	COG1475	DNA binding
HI843_RS13560	COG1192	Involved in chromosome partitioning
HI843_RS13565	COG0357	Ribosomal RNA small subunit methyltransferase G
HI843_RS13570	COG0445	tRNA wobble uridine modification
HI843_RS13575	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HI843_RS13585	COG1847	R3H domain protein
HI843_RS13590	COG0706	membrane insertase activity
HI843_RS13595	COG0594	ribonuclease P activity
HI843_RS13600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HI843_RS13765	COG1754	DNA topoisomerase type I activity
HI843_RS13765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HI843_RS13770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HI843_RS13915	COG3328	transposase activity
HI843_RS13935	COG3775	system Galactitol-specific IIC component
HI843_RS13950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HI843_RS13960	COG4372	Transposase
HI843_RS13995	COG1940	carbohydrate kinase activity
HI843_RS14000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS14000	COG1263	PTS System
HI843_RS14000	COG2190	(PTS) system
HI843_RS14005	COG1621	beta-fructofuranosidase activity
HI843_RS14010	COG1609	Transcriptional regulator
HI843_RS14040	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HI843_RS14045	COG2190	(PTS) system
HI843_RS14045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS14045	COG1263	PTS System
HI843_RS14050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI843_RS14050	COG1263	PTS System
HI843_RS14050	COG2190	(PTS) system
HI843_RS14070	COG4974	Belongs to the 'phage' integrase family
HI843_RS14080	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI843_RS14090	COG3684	Belongs to the aldolase LacD family
HI843_RS14095	COG2222	sugar isomerase
HI843_RS14100	COG2188	Transcriptional regulator
HI843_RS14110	COG3328	transposase activity
HI843_RS14125	COG3328	transposase activity
HI843_RS14130	COG5002	protein histidine kinase activity
HI843_RS14145	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HI843_RS14160	COG3842	ATPase activity
HI843_RS14170	COG0395	ABC-type sugar transport system, permease component
HI843_RS14185	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HI843_RS14205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HI843_RS14220	COG1136	(ABC) transporter
HI843_RS14240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI843_RS14275	COG0582	viral genome integration into host DNA
HI843_RS14300	COG4372	Transposase
HI843_RS14325	COG0464	growth
HI843_RS14345	COG0456	acetyltransferase
HI843_RS14400	COG1192	Involved in chromosome partitioning
HI843_RS14535	COG1940	carbohydrate kinase activity
HI843_RS14545	COG0395	ABC-type sugar transport system, permease component
HI843_RS14550	COG1175	transmembrane transport
HI843_RS14560	COG1609	Transcriptional regulator
HI843_RS14600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HI843_RS14630	COG3976	FMN-binding domain protein
HI843_RS14630	COG0431	NADPH-dependent FMN reductase
HI843_RS14630	COG1053	succinate dehydrogenase
HI843_RS14710	COG2226	methyltransferase
HI843_RS14720	COG0456	acetyltransferase
HI843_RS14730	COG2378	regulation of single-species biofilm formation
HI843_RS14870	COG4115	mRNA cleavage
HI843_RS14895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HI843_RS14915	COG1192	Involved in chromosome partitioning
HI843_RS15005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HI843_RS15065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA