locus-tag	class	description
HI848_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HI848_RS00010	COG0592	DNA-directed DNA polymerase activity
HI848_RS00015	COG2501	S4 domain
HI848_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HI848_RS00025	COG0187	DNA topoisomerase II activity
HI848_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
HI848_RS00040	COG0629	single-stranded DNA binding
HI848_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HI848_RS00055	COG0359	binds to the 23S rRNA
HI848_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
HI848_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HI848_RS00075	COG0488	(ABC) transporter
HI848_RS00085	COG0028	Belongs to the TPP enzyme family
HI848_RS00155	COG2723	6-phospho-beta-galactosidase activity
HI848_RS00165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS00165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS00175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HI848_RS00175	COG0519	Catalyzes the synthesis of GMP from XMP
HI848_RS00180	COG1072	(Pantothenic acid kinase))
HI848_RS00185	COG2813	Specifically methylates the guanine in position
HI848_RS00190	COG1609	Transcriptional regulator
HI848_RS00195	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HI848_RS00200	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HI848_RS00205	COG0295	cytidine deaminase activity
HI848_RS00210	COG1744	ABC transporter substrate-binding protein PnrA-like
HI848_RS00215	COG3845	ABC transporter
HI848_RS00220	COG4603	Belongs to the binding-protein-dependent transport system permease family
HI848_RS00225	COG1079	Belongs to the binding-protein-dependent transport system permease family
HI848_RS00230	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HI848_RS00240	COG0813	purine-nucleoside phosphorylase activity
HI848_RS00245	COG0588	phosphoglycerate mutase activity
HI848_RS00255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HI848_RS00260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HI848_RS00265	COG0049	tRNA binding
HI848_RS00270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HI848_RS00275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HI848_RS00280	COG0051	transcription antitermination factor activity, RNA binding
HI848_RS00285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HI848_RS00290	COG0088	Forms part of the polypeptide exit tunnel
HI848_RS00295	COG0089	rRNA binding
HI848_RS00300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HI848_RS00310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HI848_RS00315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HI848_RS00320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HI848_RS00325	COG0255	Belongs to the universal ribosomal protein uL29 family
HI848_RS00330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HI848_RS00335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HI848_RS00340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HI848_RS00345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HI848_RS00350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HI848_RS00355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HI848_RS00360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HI848_RS00365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HI848_RS00370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HI848_RS00375	COG1841	ribosomal large subunit assembly
HI848_RS00380	COG0200	Binds to the 23S rRNA
HI848_RS00385	COG0201	protein transport
HI848_RS00390	COG0563	adenylate kinase activity
HI848_RS00395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HI848_RS00400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HI848_RS00405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HI848_RS00410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HI848_RS00415	COG0202	RNA polymerase activity
HI848_RS00420	COG0203	ribosomal protein L17
HI848_RS00425	COG1122	ATPase activity
HI848_RS00430	COG1122	ATPase activity
HI848_RS00440	COG0101	tRNA pseudouridine synthase activity
HI848_RS00450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HI848_RS00460	COG1461	Dihydroxyacetone kinase
HI848_RS00465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HI848_RS00470	COG0416	fatty acid biosynthetic process
HI848_RS00475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HI848_RS00485	COG4608	Belongs to the ABC transporter superfamily
HI848_RS00490	COG0601	transmembrane transport
HI848_RS00505	COG0571	ribonuclease III activity
HI848_RS00510	COG1196	nuclear chromosome segregation
HI848_RS00515	COG0561	phosphatase activity
HI848_RS00520	COG0552	protein localization to endoplasmic reticulum
HI848_RS00525	COG1181	Belongs to the D-alanine--D-alanine ligase family
HI848_RS00525	COG2918	glutathione biosynthetic process
HI848_RS00535	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HI848_RS00540	COG4605	iron ion homeostasis
HI848_RS00545	COG4604	ABC transporter, ATP-binding protein
HI848_RS00550	COG4607	ABC-type enterochelin transport system periplasmic component
HI848_RS00570	COG3328	transposase activity
HI848_RS00590	COG1380	Effector of murein hydrolase LrgA
HI848_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
HI848_RS00620	COG1268	BioY protein
HI848_RS00630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HI848_RS00645	COG0561	phosphatase activity
HI848_RS00650	COG1692	metallophosphoesterase
HI848_RS00660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HI848_RS00670	COG0424	maF-like protein
HI848_RS00675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS00675	COG1263	PTS System
HI848_RS00680	COG2188	Transcriptional regulator
HI848_RS00690	COG0632	four-way junction helicase activity
HI848_RS00695	COG2255	four-way junction helicase activity
HI848_RS00705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HI848_RS00715	COG1114	Component of the transport system for branched-chain amino acids
HI848_RS00725	COG1113	amino acid transport
HI848_RS00730	COG1126	abc transporter atp-binding protein
HI848_RS00735	COG0765	amino acid transport
HI848_RS00745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HI848_RS00750	COG0110	maltose O-acetyltransferase activity
HI848_RS00755	COG1827	regulation of RNA biosynthetic process
HI848_RS00760	COG0242	peptide deformylase activity
HI848_RS00765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HI848_RS00770	COG1185	polyribonucleotide nucleotidyltransferase activity
HI848_RS00780	COG3158	transport of potassium into the cell
HI848_RS00790	COG1253	flavin adenine dinucleotide binding
HI848_RS00795	COG0534	Mate efflux family protein
HI848_RS00805	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HI848_RS00810	COG1187	pseudouridine synthase activity
HI848_RS00815	COG1011	Hydrolase
HI848_RS00820	COG0572	uridine kinase
HI848_RS00845	COG1671	Belongs to the UPF0178 family
HI848_RS00855	COG1181	Belongs to the D-alanine--D-alanine ligase family
HI848_RS00860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HI848_RS00875	COG0736	holo-[acyl-carrier-protein] synthase activity
HI848_RS00880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HI848_RS00885	COG2337	Toxic component of a toxin-antitoxin (TA) module
HI848_RS00890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HI848_RS00895	COG3321	synthase
HI848_RS00895	COG0604	alcohol dehydrogenase
HI848_RS00905	COG0531	amino acid
HI848_RS00930	COG1174	glycine betaine transport
HI848_RS00950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HI848_RS00960	COG2826	transposase and inactivated derivatives, IS30 family
HI848_RS00965	COG0343	queuine tRNA-ribosyltransferase activity
HI848_RS00970	COG1862	Preprotein translocase
HI848_RS00975	COG1012	belongs to the aldehyde dehydrogenase family
HI848_RS00975	COG1454	alcohol dehydrogenase
HI848_RS00985	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HI848_RS01015	COG2207	Transcriptional regulator
HI848_RS01015	COG1917	Cupin 2, conserved barrel domain protein
HI848_RS01020	COG1070	Carbohydrate kinase
HI848_RS01025	COG4806	L-rhamnose isomerase
HI848_RS01030	COG0235	Class ii aldolase
HI848_RS01035	COG3254	rhamnose metabolic process
HI848_RS01040	COG1454	alcohol dehydrogenase
HI848_RS01045	COG1414	Transcriptional regulator
HI848_RS01050	COG0800	Aldolase
HI848_RS01060	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HI848_RS01065	COG1028	Short-chain dehydrogenase reductase Sdr
HI848_RS01070	COG1304	FMN binding
HI848_RS01085	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HI848_RS01090	COG1428	Deoxynucleoside kinase
HI848_RS01105	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HI848_RS01110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HI848_RS01115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HI848_RS01145	COG0824	Thioesterase
HI848_RS01150	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HI848_RS01175	COG1363	Peptidase, m42
HI848_RS01180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI848_RS01185	COG0589	response to stress
HI848_RS01190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI848_RS01195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HI848_RS01200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HI848_RS01245	COG1368	sulfuric ester hydrolase activity
HI848_RS01255	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HI848_RS01265	COG0101	tRNA pseudouridine synthase activity
HI848_RS01275	COG3328	transposase activity
HI848_RS01300	COG0667	Aldo Keto reductase
HI848_RS01305	COG2186	Transcriptional regulator
HI848_RS01310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS01315	COG2723	6-phospho-beta-galactosidase activity
HI848_RS01325	COG1447	Phosphotransferase system cellobiose-specific component IIA
HI848_RS01355	COG1063	alcohol dehydrogenase
HI848_RS01365	COG4716	Myosin-crossreactive antigen
HI848_RS01405	COG1113	amino acid transport
HI848_RS01430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HI848_RS01440	COG3052	prosthetic group binding
HI848_RS01505	COG1051	belongs to the nudix hydrolase family
HI848_RS01510	COG1846	Transcriptional regulator
HI848_RS01535	COG2252	PERMEase
HI848_RS01540	COG0366	Alpha amylase catalytic
HI848_RS01545	COG2723	6-phospho-beta-galactosidase activity
HI848_RS01555	COG2190	(PTS) system
HI848_RS01555	COG1263	PTS System
HI848_RS01555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS01560	COG2723	6-phospho-beta-galactosidase activity
HI848_RS01570	COG1902	pentaerythritol trinitrate reductase activity
HI848_RS01580	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI848_RS01590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HI848_RS01595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HI848_RS01600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HI848_RS01605	COG1193	negative regulation of DNA recombination
HI848_RS01610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HI848_RS01620	COG1937	Protein conserved in bacteria
HI848_RS01625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HI848_RS01630	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI848_RS01635	COG3973	AAA domain
HI848_RS01660	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HI848_RS01665	COG2376	Dihydroxyacetone kinase
HI848_RS01670	COG1461	Dihydroxyacetone kinase
HI848_RS01680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI848_RS01690	COG1131	(ABC) transporter
HI848_RS01695	COG1309	transcriptional regulator
HI848_RS01715	COG0531	amino acid
HI848_RS01725	COG1757	Na H antiporter
HI848_RS01730	COG1609	Transcriptional regulator
HI848_RS01740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI848_RS01750	COG1263	PTS System
HI848_RS01750	COG2190	(PTS) system
HI848_RS01750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS01775	COG3479	Phenolic acid decarboxylase
HI848_RS01780	COG1695	Transcriptional regulator
HI848_RS01790	COG2814	Major facilitator Superfamily
HI848_RS01810	COG0163	prenyltransferase activity
HI848_RS01815	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HI848_RS01825	COG0577	efflux transmembrane transporter activity
HI848_RS01825	COG1136	(ABC) transporter
HI848_RS01845	COG1811	Na channel or pump
HI848_RS01880	COG1136	(ABC) transporter
HI848_RS01895	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI848_RS01895	COG3942	CHAP domain
HI848_RS01900	COG1263	PTS System
HI848_RS01900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS01900	COG2190	(PTS) system
HI848_RS01905	COG1869	D-ribose catabolic process
HI848_RS01915	COG1609	Transcriptional regulator
HI848_RS01935	COG0366	Alpha amylase catalytic
HI848_RS01940	COG0628	permease
HI848_RS01945	COG3443	Belongs to the bacterial solute-binding protein 9 family
HI848_RS01945	COG0803	Belongs to the bacterial solute-binding protein 9 family
HI848_RS01975	COG1428	Deoxynucleoside kinase
HI848_RS01985	COG0210	DNA helicase
HI848_RS01990	COG1393	Belongs to the ArsC family
HI848_RS01995	COG1393	Belongs to the ArsC family
HI848_RS02015	COG0386	Belongs to the glutathione peroxidase family
HI848_RS02020	COG1854	S-ribosylhomocysteine lyase activity
HI848_RS02025	COG0626	cystathionine gamma-synthase activity
HI848_RS02030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HI848_RS02035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HI848_RS02045	COG0019	diaminopimelate decarboxylase activity
HI848_RS02050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HI848_RS02060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HI848_RS02065	COG2171	N-acyltransferase activity
HI848_RS02070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HI848_RS02075	COG0527	aspartate kinase activity
HI848_RS02080	COG1473	amidohydrolase
HI848_RS02085	COG0436	Aminotransferase
HI848_RS02090	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI848_RS02110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HI848_RS02115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HI848_RS02130	COG2207	Transcriptional regulator
HI848_RS02135	COG2249	NAD(P)H dehydrogenase (quinone) activity
HI848_RS02150	COG1113	amino acid transport
HI848_RS02155	COG1121	(ABC) transporter
HI848_RS02160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HI848_RS02175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HI848_RS02180	COG1652	LysM domain
HI848_RS02180	COG2823	Periplasmic or secreted lipoprotein
HI848_RS02190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HI848_RS02200	COG0477	Major facilitator Superfamily
HI848_RS02210	COG1438	arginine binding
HI848_RS02225	COG1764	response to oxidative stress
HI848_RS02230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HI848_RS02235	COG1335	isochorismatase
HI848_RS02250	COG2135	peptidase activity
HI848_RS02285	COG3546	catalase activity
HI848_RS02295	COG1175	transmembrane transport
HI848_RS02300	COG0395	ABC-type sugar transport system, permease component
HI848_RS02340	COG0745	RESPONSE REGULATOR receiver
HI848_RS02345	COG2205	protein histidine kinase activity
HI848_RS02350	COG4975	Glucose uptake
HI848_RS02355	COG0531	amino acid
HI848_RS02360	COG3853	Toxic anion resistance protein (TelA)
HI848_RS02380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HI848_RS02385	COG1335	isochorismatase
HI848_RS02390	COG2826	transposase and inactivated derivatives, IS30 family
HI848_RS02400	COG3590	peptidase
HI848_RS02410	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HI848_RS02415	COG1104	cysteine desulfurase activity
HI848_RS02435	COG0482	sulfurtransferase activity
HI848_RS02445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HI848_RS02450	COG2814	Major facilitator Superfamily
HI848_RS02470	COG0463	Glycosyl transferase, family 2
HI848_RS02475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HI848_RS02480	COG2855	membrane
HI848_RS02490	COG0583	DNA-binding transcription factor activity
HI848_RS02495	COG0772	Belongs to the SEDS family
HI848_RS02500	COG1393	Belongs to the ArsC family
HI848_RS02505	COG0509	glycine decarboxylation via glycine cleavage system
HI848_RS02510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HI848_RS02515	COG2011	ABC-type metal ion transport system permease component
HI848_RS02520	COG1464	Belongs to the NlpA lipoprotein family
HI848_RS02530	COG0719	Fe-S assembly protein
HI848_RS02535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HI848_RS02545	COG0719	Fe-S assembly protein
HI848_RS02590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS02590	COG2190	(PTS) system
HI848_RS02590	COG1263	PTS System
HI848_RS02595	COG2723	6-phospho-beta-galactosidase activity
HI848_RS02600	COG3711	transcriptional antiterminator
HI848_RS02620	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HI848_RS02635	COG1136	(ABC) transporter
HI848_RS02635	COG0577	efflux transmembrane transporter activity
HI848_RS02645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HI848_RS02655	COG1597	lipid kinase activity
HI848_RS02690	COG1733	regulation of RNA biosynthetic process
HI848_RS02700	COG3764	Sortase (surface protein transpeptidase)
HI848_RS02705	COG3711	transcriptional antiterminator
HI848_RS02710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS02710	COG1263	PTS System
HI848_RS02710	COG2190	(PTS) system
HI848_RS02715	COG2723	6-phospho-beta-galactosidase activity
HI848_RS02735	COG1611	Belongs to the LOG family
HI848_RS02745	COG1428	Deoxynucleoside kinase
HI848_RS02755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS02760	COG1472	Belongs to the glycosyl hydrolase 3 family
HI848_RS02770	COG2723	6-phospho-beta-galactosidase activity
HI848_RS02785	COG1368	sulfuric ester hydrolase activity
HI848_RS02795	COG0105	UTP biosynthetic process
HI848_RS02800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI848_RS02810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HI848_RS02815	COG2011	ABC-type metal ion transport system permease component
HI848_RS02820	COG1464	Belongs to the NlpA lipoprotein family
HI848_RS02825	COG1473	amidohydrolase
HI848_RS02830	COG1757	Na H antiporter
HI848_RS02840	COG1113	amino acid transport
HI848_RS02850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HI848_RS02855	COG1929	Belongs to the glycerate kinase type-1 family
HI848_RS02860	COG0488	(ABC) transporter
HI848_RS02875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HI848_RS02880	COG1263	PTS System
HI848_RS02880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS02885	COG1780	Probably involved in ribonucleotide reductase function
HI848_RS02895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HI848_RS02900	COG1131	(ABC) transporter
HI848_RS02920	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HI848_RS02935	COG0346	lactoylglutathione lyase activity
HI848_RS02960	COG0561	phosphatase activity
HI848_RS02965	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HI848_RS02970	COG0280	phosphate acetyltransferase
HI848_RS02975	COG0802	atpase or kinase
HI848_RS02980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HI848_RS02990	COG0708	Exodeoxyribonuclease III
HI848_RS03000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HI848_RS03025	COG1053	succinate dehydrogenase
HI848_RS03030	COG1028	Short-chain dehydrogenase reductase Sdr
HI848_RS03030	COG3321	synthase
HI848_RS03030	COG0604	alcohol dehydrogenase
HI848_RS03035	COG0702	epimerase
HI848_RS03040	COG4684	Psort location CytoplasmicMembrane, score
HI848_RS03045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HI848_RS03050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HI848_RS03055	COG0604	alcohol dehydrogenase
HI848_RS03065	COG3842	ATPase activity
HI848_RS03070	COG1176	ABC-type spermidine putrescine transport system, permease component I
HI848_RS03075	COG1177	transmembrane transport
HI848_RS03080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HI848_RS03085	COG3829	transcription factor binding
HI848_RS03100	COG3715	PTS system
HI848_RS03105	COG3716	PTS system mannose fructose sorbose family IID component
HI848_RS03120	COG1940	carbohydrate kinase activity
HI848_RS03155	COG0582	viral genome integration into host DNA
HI848_RS03160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HI848_RS03170	COG0789	Transcriptional regulator
HI848_RS03180	COG0504	CTP synthase activity
HI848_RS03190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HI848_RS03195	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HI848_RS03200	COG0254	rRNA binding
HI848_RS03220	COG1349	DNA-binding transcription factor activity
HI848_RS03230	COG2814	Major facilitator Superfamily
HI848_RS03240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI848_RS03260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HI848_RS03265	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HI848_RS03270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HI848_RS03275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HI848_RS03280	COG3870	Protein conserved in bacteria
HI848_RS03285	COG0470	DNA polymerase III
HI848_RS03290	COG1774	PSP1 C-terminal conserved region
HI848_RS03295	COG4467	Involved in initiation control of chromosome replication
HI848_RS03310	COG0602	queuosine metabolic process
HI848_RS03315	COG1328	CTP reductase activity
HI848_RS03320	COG1136	(ABC) transporter
HI848_RS03325	COG0577	efflux transmembrane transporter activity
HI848_RS03330	COG2826	transposase and inactivated derivatives, IS30 family
HI848_RS03340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HI848_RS03345	COG1696	Membrane protein involved in D-alanine export
HI848_RS03350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HI848_RS03355	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HI848_RS03360	COG1363	Peptidase, m42
HI848_RS03380	COG1234	tRNA 3'-trailer cleavage
HI848_RS03385	COG0095	Lipoate-protein ligase
HI848_RS03410	COG3759	membrane
HI848_RS03415	COG0659	secondary active sulfate transmembrane transporter activity
HI848_RS03425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HI848_RS03435	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HI848_RS03440	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HI848_RS03440	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HI848_RS03445	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS03445	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI848_RS03455	COG3715	PTS system
HI848_RS03460	COG3716	PTS system mannose fructose sorbose family IID component
HI848_RS03470	COG2261	transglycosylase associated protein
HI848_RS03475	COG0006	proline dipeptidase activity
HI848_RS03480	COG1302	Protein conserved in bacteria
HI848_RS03485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HI848_RS03490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HI848_RS03495	COG1570	exodeoxyribonuclease VII activity
HI848_RS03500	COG1722	exodeoxyribonuclease VII activity
HI848_RS03510	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HI848_RS03515	COG1438	arginine binding
HI848_RS03520	COG0497	DNA recombination
HI848_RS03555	COG0768	penicillin binding
HI848_RS03590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HI848_RS03595	COG1799	cell septum assembly
HI848_RS03605	COG2302	S4 RNA-binding domain
HI848_RS03610	COG3599	regulation of cell shape
HI848_RS03615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HI848_RS03620	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HI848_RS03640	COG0673	inositol 2-dehydrogenase activity
HI848_RS03645	COG0513	Belongs to the DEAD box helicase family
HI848_RS03650	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HI848_RS03650	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HI848_RS03655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS03660	COG1447	Phosphotransferase system cellobiose-specific component IIA
HI848_RS03665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS03710	COG2309	aminopeptidase activity
HI848_RS03720	COG0716	FMN binding
HI848_RS03725	COG0024	Methionine aminopeptidase
HI848_RS03730	COG1295	ribonuclease BN
HI848_RS03735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HI848_RS03750	COG1215	transferase activity, transferring glycosyl groups
HI848_RS03755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HI848_RS03765	COG1088	dTDP-glucose 4,6-dehydratase activity
HI848_RS03770	COG1091	dTDP-4-dehydrorhamnose reductase activity
HI848_RS03785	COG1682	transport, permease protein
HI848_RS03795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HI848_RS03800	COG1216	Glycosyl transferase, family 2
HI848_RS03800	COG0438	transferase activity, transferring glycosyl groups
HI848_RS03810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HI848_RS03815	COG0463	Glycosyl transferase, family 2
HI848_RS03820	COG0438	transferase activity, transferring glycosyl groups
HI848_RS03845	COG1086	Polysaccharide biosynthesis protein
HI848_RS03850	COG2089	acid synthase
HI848_RS03855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HI848_RS03865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HI848_RS03880	COG1083	cytidylyl-transferase
HI848_RS03910	COG3328	transposase activity
HI848_RS03925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HI848_RS03930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HI848_RS03940	COG4585	Histidine kinase
HI848_RS03950	COG0569	domain protein
HI848_RS03975	COG2246	polysaccharide biosynthetic process
HI848_RS03980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HI848_RS03990	COG1316	TRANSCRIPTIONal
HI848_RS03995	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HI848_RS04000	COG3397	chitin binding
HI848_RS04005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HI848_RS04010	COG2137	regulation of response to DNA damage stimulus
HI848_RS04015	COG1194	a g-specific adenine glycosylase
HI848_RS04020	COG3557	Belongs to the UPF0374 family
HI848_RS04035	COG0628	permease
HI848_RS04040	COG1253	flavin adenine dinucleotide binding
HI848_RS04045	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HI848_RS04060	COG0542	response to heat
HI848_RS04065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI848_RS04070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HI848_RS04080	COG0438	transferase activity, transferring glycosyl groups
HI848_RS04085	COG2084	Dehydrogenase
HI848_RS04090	COG4703	Protein of unknown function (DUF1797)
HI848_RS04095	COG0322	excinuclease ABC activity
HI848_RS04100	COG1846	Transcriptional regulator
HI848_RS04105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HI848_RS04115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HI848_RS04125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HI848_RS04135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HI848_RS04140	COG0439	Biotin carboxylase
HI848_RS04145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HI848_RS04150	COG0825	malonyl-CoA metabolic process
HI848_RS04155	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HI848_RS04160	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HI848_RS04165	COG1534	Rna-binding protein
HI848_RS04170	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HI848_RS04175	COG1713	HD superfamily hydrolase involved in NAD metabolism
HI848_RS04180	COG0799	negative regulation of ribosome biogenesis
HI848_RS04185	COG2226	methyltransferase
HI848_RS04190	COG1323	Belongs to the UPF0348 family
HI848_RS04195	COG0217	transcriptional regulatory protein
HI848_RS04205	COG3973	AAA domain
HI848_RS04210	COG2217	Heavy metal translocating P-type atpase
HI848_RS04215	COG1942	4-Oxalocrotonate Tautomerase
HI848_RS04220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HI848_RS04225	COG1737	Transcriptional regulator
HI848_RS04230	COG0768	penicillin binding
HI848_RS04240	COG0561	phosphatase activity
HI848_RS04245	COG2252	PERMEase
HI848_RS04250	COG2814	Major facilitator Superfamily
HI848_RS04260	COG0587	DNA-directed DNA polymerase activity
HI848_RS04265	COG0205	6-phosphofructokinase activity
HI848_RS04275	COG0583	DNA-binding transcription factor activity
HI848_RS04285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HI848_RS04290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HI848_RS04295	COG0745	RESPONSE REGULATOR receiver
HI848_RS04300	COG5002	protein histidine kinase activity
HI848_RS04400	COG3711	transcriptional antiterminator
HI848_RS04410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS04410	COG1263	PTS System
HI848_RS04410	COG2190	(PTS) system
HI848_RS04420	COG2190	(PTS) system
HI848_RS04420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS04420	COG1263	PTS System
HI848_RS04425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS04445	COG1349	DNA-binding transcription factor activity
HI848_RS04470	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HI848_RS04475	COG3623	hexulose-6-phosphate isomerase
HI848_RS04485	COG0456	acetyltransferase
HI848_RS04495	COG3328	transposase activity
HI848_RS04505	COG2116	formate transmembrane transporter activity
HI848_RS04520	COG1349	DNA-binding transcription factor activity
HI848_RS04525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HI848_RS04530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HI848_RS04540	COG3328	transposase activity
HI848_RS04560	COG3775	system Galactitol-specific IIC component
HI848_RS04575	COG0400	carboxylic ester hydrolase activity
HI848_RS04580	COG0346	lactoylglutathione lyase activity
HI848_RS04585	COG2188	Transcriptional regulator
HI848_RS04590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS04595	COG2723	6-phospho-beta-galactosidase activity
HI848_RS04600	COG0589	response to stress
HI848_RS04615	COG1393	Belongs to the ArsC family
HI848_RS04630	COG0351	phosphomethylpyrimidine kinase
HI848_RS04635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HI848_RS04640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI848_RS04650	COG3425	synthase
HI848_RS04655	COG0183	Belongs to the thiolase family
HI848_RS04670	COG0656	L-ascorbic acid biosynthetic process
HI848_RS04690	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HI848_RS04690	COG0392	lysyltransferase activity
HI848_RS04695	COG0596	Alpha beta hydrolase
HI848_RS04700	COG0741	lytic transglycosylase activity
HI848_RS04710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI848_RS04715	COG0358	DNA primase activity
HI848_RS04720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HI848_RS04735	COG2996	Protein conserved in bacteria
HI848_RS04740	COG0735	belongs to the Fur family
HI848_RS04745	COG4974	Belongs to the 'phage' integrase family
HI848_RS04755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HI848_RS04760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HI848_RS04765	COG1187	pseudouridine synthase activity
HI848_RS04770	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HI848_RS04775	COG1288	antiporter activity
HI848_RS04780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HI848_RS04800	COG0514	ATP-dependent DNA helicase (RecQ)
HI848_RS04810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HI848_RS04815	COG0539	negative regulation of cytoplasmic translation
HI848_RS04820	COG1160	GTP binding
HI848_RS04825	COG0776	regulation of translation
HI848_RS04835	COG0457	Tetratricopeptide repeat
HI848_RS04840	COG5582	Belongs to the UPF0302 family
HI848_RS04845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI848_RS04850	COG1694	Mazg nucleotide pyrophosphohydrolase
HI848_RS04855	COG0617	tRNA 3'-terminal CCA addition
HI848_RS04870	COG0025	NhaP-type Na H and K H
HI848_RS04875	COG0488	(ABC) transporter
HI848_RS04880	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HI848_RS04890	COG1272	protein, Hemolysin III
HI848_RS04895	COG1307	EDD domain protein, DegV family
HI848_RS04900	COG2755	lipolytic protein G-D-S-L family
HI848_RS04905	COG4698	Protein conserved in bacteria
HI848_RS04915	COG4479	Belongs to the UPF0346 family
HI848_RS04920	COG0681	Belongs to the peptidase S26 family
HI848_RS04940	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HI848_RS04945	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HI848_RS04950	COG0758	DNA mediated transformation
HI848_RS04955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HI848_RS04960	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HI848_RS04965	COG4974	Belongs to the 'phage' integrase family
HI848_RS04970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HI848_RS04975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HI848_RS04990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HI848_RS04995	COG1832	CoA-binding protein
HI848_RS05000	COG0187	DNA topoisomerase II activity
HI848_RS05010	COG1882	Formate acetyltransferase
HI848_RS05015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HI848_RS05020	COG1227	inorganic diphosphatase activity
HI848_RS05040	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HI848_RS05050	COG1073	alpha beta
HI848_RS05055	COG1609	Transcriptional regulator
HI848_RS05065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI848_RS05075	COG1732	Glycine betaine
HI848_RS05090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HI848_RS05100	COG1116	anion transmembrane transporter activity
HI848_RS05105	COG0084	hydrolase, TatD family'
HI848_RS05110	COG1388	LysM domain
HI848_RS05110	COG3942	CHAP domain
HI848_RS05130	COG3328	transposase activity
HI848_RS05150	COG0436	Aminotransferase
HI848_RS05175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HI848_RS05180	COG4565	transcriptional regulatory protein
HI848_RS05185	COG3290	protein histidine kinase activity
HI848_RS05190	COG3290	protein histidine kinase activity
HI848_RS05200	COG2268	Band 7 protein
HI848_RS05215	COG0673	inositol 2-dehydrogenase activity
HI848_RS05225	COG1876	peptidase activity
HI848_RS05230	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI848_RS05230	COG1388	LysM domain
HI848_RS05240	COG1653	transport
HI848_RS05245	COG1175	transmembrane transport
HI848_RS05250	COG0395	ABC-type sugar transport system, permease component
HI848_RS05260	COG0673	inositol 2-dehydrogenase activity
HI848_RS05265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HI848_RS05270	COG2233	PERMEase
HI848_RS05275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HI848_RS05280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HI848_RS05285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HI848_RS05295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HI848_RS05300	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HI848_RS05305	COG0047	phosphoribosylformylglycinamidine synthase activity
HI848_RS05310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HI848_RS05320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HI848_RS05325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HI848_RS05330	COG0138	bifunctional purine biosynthesis protein purh
HI848_RS05335	COG0151	Belongs to the GarS family
HI848_RS05340	COG4989	oxidoreductase activity
HI848_RS05355	COG2972	Histidine kinase
HI848_RS05365	COG4213	ABC transporter substrate-binding protein
HI848_RS05375	COG4214	carbohydrate transport
HI848_RS05380	COG0516	GMP reductase activity
HI848_RS05385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HI848_RS05395	COG0022	dehydrogenase e1 component
HI848_RS05410	COG4476	Belongs to the UPF0223 family
HI848_RS05415	COG0483	inositol monophosphate 1-phosphatase activity
HI848_RS05420	COG1217	gtp-binding protein TYPA
HI848_RS05425	COG0514	ATP-dependent DNA helicase (RecQ)
HI848_RS05430	COG4838	Belongs to the UPF0358 family
HI848_RS05435	COG0772	Belongs to the SEDS family
HI848_RS05440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HI848_RS05455	COG4471	UPF0298 protein
HI848_RS05460	COG0742	ribosomal rna small subunit methyltransferase
HI848_RS05465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HI848_RS05470	COG3480	Lon protease (S16) C-terminal proteolytic domain
HI848_RS05475	COG1596	polysaccharide export
HI848_RS05475	COG1555	photosystem II stabilization
HI848_RS05490	COG2131	deaminase
HI848_RS05495	COG2333	competence protein COMEC
HI848_RS05495	COG0658	competence protein
HI848_RS05500	COG1466	dna polymerase III delta subunit
HI848_RS05505	COG0268	Binds directly to 16S ribosomal RNA
HI848_RS05515	COG2707	UPF0756 membrane protein
HI848_RS05520	COG2217	Heavy metal translocating P-type atpase
HI848_RS05525	COG1968	undecaprenyl-diphosphatase activity
HI848_RS05550	COG1666	GTP binding
HI848_RS05555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI848_RS05560	COG2151	metal-sulfur cluster biosynthetic enzyme
HI848_RS05575	COG1388	LysM domain
HI848_RS05575	COG3942	CHAP domain
HI848_RS05630	COG4990	cell redox homeostasis
HI848_RS05650	COG3104	oligopeptide transport
HI848_RS05660	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HI848_RS05665	COG1074	ATP-dependent DNA helicase activity
HI848_RS05670	COG1733	regulation of RNA biosynthetic process
HI848_RS05675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HI848_RS05680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI848_RS05680	COG0072	phenylalanine-tRNA ligase activity
HI848_RS05690	COG1126	abc transporter atp-binding protein
HI848_RS05695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI848_RS05700	COG0765	amino acid transport
HI848_RS05705	COG0765	amino acid transport
HI848_RS05715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HI848_RS05720	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HI848_RS05730	COG0517	IMP dehydrogenase activity
HI848_RS05735	COG0668	transmembrane transport
HI848_RS05740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HI848_RS05745	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HI848_RS05750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HI848_RS05780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HI848_RS05790	COG1234	tRNA 3'-trailer cleavage
HI848_RS05795	COG0300	oxidoreductase activity
HI848_RS05800	COG5416	Lipopolysaccharide assembly protein A domain
HI848_RS05805	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HI848_RS05805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HI848_RS05810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HI848_RS05820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HI848_RS05835	COG2826	transposase and inactivated derivatives, IS30 family
HI848_RS05840	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI848_RS05840	COG1388	LysM domain
HI848_RS05845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HI848_RS05850	COG0735	belongs to the Fur family
HI848_RS05855	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI848_RS05870	COG1846	Transcriptional regulator
HI848_RS05880	COG3935	DnaD domain protein
HI848_RS05885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HI848_RS05895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HI848_RS05900	COG3331	DNA recombination
HI848_RS05905	COG4474	Belongs to the UPF0398 family
HI848_RS05910	COG3599	regulation of cell shape
HI848_RS05920	COG0116	Belongs to the methyltransferase superfamily
HI848_RS05925	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HI848_RS05930	COG1418	mRNA catabolic process
HI848_RS05935	COG0156	8-amino-7-oxononanoate synthase activity
HI848_RS05940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HI848_RS05945	COG0531	amino acid
HI848_RS05960	COG0513	Belongs to the DEAD box helicase family
HI848_RS05965	COG2153	protein acetylation
HI848_RS05970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HI848_RS05975	COG4684	Psort location CytoplasmicMembrane, score
HI848_RS05985	COG0328	RNA-DNA hybrid ribonuclease activity
HI848_RS06000	COG1278	Cold shock
HI848_RS06005	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HI848_RS06020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HI848_RS06025	COG0564	pseudouridine synthase activity
HI848_RS06035	COG2233	PERMEase
HI848_RS06040	COG0540	Belongs to the ATCase OTCase family
HI848_RS06045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HI848_RS06050	COG0505	Belongs to the CarA family
HI848_RS06055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HI848_RS06060	COG0543	2 iron, 2 sulfur cluster binding
HI848_RS06070	COG0284	orotidine-5'-phosphate decarboxylase activity
HI848_RS06100	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HI848_RS06115	COG4120	Belongs to the binding-protein-dependent transport system permease family
HI848_RS06125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HI848_RS06160	COG0039	L-malate dehydrogenase activity
HI848_RS06180	COG3037	sugar-specific permease SgaT UlaA
HI848_RS06190	COG3711	transcriptional antiterminator
HI848_RS06200	COG0673	inositol 2-dehydrogenase activity
HI848_RS06250	COG0745	RESPONSE REGULATOR receiver
HI848_RS06255	COG5002	protein histidine kinase activity
HI848_RS06260	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HI848_RS06270	COG0318	PFAM AMP-dependent synthetase and ligase
HI848_RS06275	COG0351	phosphomethylpyrimidine kinase
HI848_RS06285	COG4475	Protein of unknown function (DUF436)
HI848_RS06290	COG0366	Alpha amylase catalytic
HI848_RS06310	COG1307	EDD domain protein, DegV family
HI848_RS06315	COG2244	polysaccharide biosynthetic process
HI848_RS06365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HI848_RS06370	COG0194	GDP metabolic process
HI848_RS06390	COG0765	amino acid transport
HI848_RS06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI848_RS06405	COG0167	dihydroorotate dehydrogenase activity
HI848_RS06415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HI848_RS06425	COG3833	ABC-type maltose transport systems, permease component
HI848_RS06430	COG1175	transmembrane transport
HI848_RS06435	COG2182	Extracellular solute-binding protein
HI848_RS06440	COG0366	Alpha amylase catalytic
HI848_RS06445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI848_RS06455	COG1764	response to oxidative stress
HI848_RS06460	COG1846	Transcriptional regulator
HI848_RS06465	COG0628	permease
HI848_RS06480	COG1312	Catalyzes the dehydration of D-mannonate
HI848_RS06485	COG0246	Mannitol dehydrogenase
HI848_RS06495	COG0450	alkyl hydroperoxide reductase
HI848_RS06540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HI848_RS06555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HI848_RS06570	COG0531	amino acid
HI848_RS06575	COG0004	ammonium transporteR
HI848_RS06580	COG2261	transglycosylase associated protein
HI848_RS06620	COG3655	Transcriptional regulator
HI848_RS06625	COG2826	transposase and inactivated derivatives, IS30 family
HI848_RS06635	COG2261	transglycosylase associated protein
HI848_RS06655	COG1028	Short-chain dehydrogenase reductase Sdr
HI848_RS06670	COG1442	glycosyl transferase family 8
HI848_RS06675	COG1442	glycosyl transferase family 8
HI848_RS06680	COG0561	phosphatase activity
HI848_RS06705	COG1476	TRANSCRIPTIONal
HI848_RS06730	COG1278	Cold shock
HI848_RS06740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI848_RS06745	COG1312	Catalyzes the dehydration of D-mannonate
HI848_RS06765	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS06770	COG3716	PTS system mannose fructose sorbose family IID component
HI848_RS06780	COG0371	Dehydrogenase
HI848_RS06795	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HI848_RS06800	COG0837	glucose binding
HI848_RS06800	COG1737	Transcriptional regulator
HI848_RS06810	COG2272	Belongs to the type-B carboxylesterase lipase family
HI848_RS06815	COG1073	alpha beta
HI848_RS06850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HI848_RS06870	COG3732	PTS system glucitol sorbitol-specific
HI848_RS06875	COG3730	PTS system glucitol sorbitol-specific
HI848_RS06885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI848_RS06885	COG3711	transcriptional antiterminator
HI848_RS06910	COG3328	transposase activity
HI848_RS06925	COG4974	Belongs to the 'phage' integrase family
HI848_RS06930	COG0582	viral genome integration into host DNA
HI848_RS06950	COG3250	beta-galactosidase activity
HI848_RS06965	COG2211	Major facilitator Superfamily
HI848_RS06975	COG1904	glucuronate isomerase
HI848_RS06980	COG1312	Catalyzes the dehydration of D-mannonate
HI848_RS06985	COG0246	Mannitol dehydrogenase
HI848_RS07035	COG0433	COG0433 Predicted ATPase
HI848_RS07080	COG2946	Replication initiation factor
HI848_RS07090	COG1674	ftsk spoiiie
HI848_RS07130	COG0481	GTPase activity
HI848_RS07150	COG0542	response to heat
HI848_RS07155	COG2826	transposase and inactivated derivatives, IS30 family
HI848_RS07170	COG1597	lipid kinase activity
HI848_RS07175	COG2195	Cleaves the N-terminal amino acid of tripeptides
HI848_RS07180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HI848_RS07185	COG2384	SAM-dependent methyltransferase
HI848_RS07195	COG1484	DNA-dependent DNA replication
HI848_RS07205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HI848_RS07215	COG0237	dephospho-CoA kinase activity
HI848_RS07220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HI848_RS07225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HI848_RS07225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HI848_RS07245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HI848_RS07250	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HI848_RS07255	COG3091	SprT-like family
HI848_RS07260	COG2183	response to ionizing radiation
HI848_RS07270	COG1054	Belongs to the UPF0176 family
HI848_RS07290	COG0546	phosphoglycolate phosphatase activity
HI848_RS07295	COG0588	phosphoglycerate mutase activity
HI848_RS07350	COG4753	response regulator
HI848_RS07350	COG2207	Transcriptional regulator
HI848_RS07360	COG2972	Histidine kinase
HI848_RS07365	COG0077	Prephenate dehydratase
HI848_RS07370	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HI848_RS07375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HI848_RS07380	COG0287	Prephenate dehydrogenase
HI848_RS07385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HI848_RS07395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HI848_RS07400	COG3250	beta-galactosidase activity
HI848_RS07415	COG1609	Transcriptional regulator
HI848_RS07425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HI848_RS07440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HI848_RS07445	COG1597	lipid kinase activity
HI848_RS07450	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HI848_RS07455	COG0154	amidase activity
HI848_RS07460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HI848_RS07465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HI848_RS07470	COG0210	DNA helicase
HI848_RS07480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI848_RS07480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI848_RS07480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI848_RS07485	COG1105	Belongs to the carbohydrate kinase PfkB family
HI848_RS07490	COG1349	DNA-binding transcription factor activity
HI848_RS07510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HI848_RS07515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HI848_RS07520	COG0544	peptidyl-prolyl cis-trans isomerase activity
HI848_RS07530	COG1714	RDD family
HI848_RS07545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HI848_RS07555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HI848_RS07590	COG1481	regulation of sporulation
HI848_RS07595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HI848_RS07600	COG1660	Displays ATPase and GTPase activities
HI848_RS07615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HI848_RS07620	COG0556	nucleotide-excision repair
HI848_RS07625	COG0765	amino acid transport
HI848_RS07630	COG1126	abc transporter atp-binding protein
HI848_RS07635	COG0484	heat shock protein binding
HI848_RS07640	COG0443	Heat shock 70 kDa protein
HI848_RS07645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HI848_RS07650	COG1420	regulation of RNA biosynthetic process
HI848_RS07655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HI848_RS07685	COG0693	protein deglycase activity
HI848_RS07700	COG1619	proteins homologs of microcin C7 resistance protein MccF
HI848_RS07710	COG5646	InterPro IPR014922
HI848_RS07720	COG4975	Glucose uptake
HI848_RS07730	COG0196	riboflavin kinase activity
HI848_RS07735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HI848_RS07745	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HI848_RS07750	COG1175	transmembrane transport
HI848_RS07755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HI848_RS07770	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HI848_RS07775	COG0195	Participates in both transcription termination and antitermination
HI848_RS07780	COG0779	Required for maturation of 30S ribosomal subunits
HI848_RS07785	COG2176	DNA-directed DNA polymerase activity
HI848_RS07790	COG0442	prolyl-tRNA aminoacylation
HI848_RS07795	COG0750	zinc metalloprotease
HI848_RS07800	COG4589	Belongs to the CDS family
HI848_RS07805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HI848_RS07810	COG0233	cytoplasmic translational termination
HI848_RS07815	COG0528	UMP kinase activity
HI848_RS07820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HI848_RS07825	COG0052	Belongs to the universal ribosomal protein uS2 family
HI848_RS07830	COG1438	arginine binding
HI848_RS07840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI848_RS07845	COG0018	arginyl-trna synthetase
HI848_RS07860	COG2235	arginine
HI848_RS07865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI848_RS07870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HI848_RS07875	COG0456	acetyltransferase
HI848_RS07885	COG1214	PFAM Peptidase M22, glycoprotease
HI848_RS07890	COG1609	Transcriptional regulator
HI848_RS07895	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HI848_RS07900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HI848_RS07915	COG3189	MarR family transcriptional regulator
HI848_RS07920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HI848_RS07925	COG1940	carbohydrate kinase activity
HI848_RS07940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HI848_RS07945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HI848_RS07950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HI848_RS07955	COG1120	ATPase activity
HI848_RS07970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HI848_RS07975	COG4876	unkown
HI848_RS07980	COG0367	asparagine synthase
HI848_RS07985	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HI848_RS07990	COG2826	transposase and inactivated derivatives, IS30 family
HI848_RS08000	COG1309	transcriptional regulator
HI848_RS08020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HI848_RS08035	COG0584	glycerophosphoryl diester phosphodiesterase
HI848_RS08055	COG0166	Belongs to the GPI family
HI848_RS08060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HI848_RS08065	COG2081	HI0933 family
HI848_RS08070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HI848_RS08075	COG0710	3-dehydroquinate dehydratase activity
HI848_RS08080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HI848_RS08085	COG1368	sulfuric ester hydrolase activity
HI848_RS08110	COG5002	protein histidine kinase activity
HI848_RS08110	COG3850	Histidine kinase
HI848_RS08115	COG0745	RESPONSE REGULATOR receiver
HI848_RS08155	COG1956	GAF domain-containing protein
HI848_RS08160	COG3527	Alpha-acetolactate decarboxylase
HI848_RS08165	COG0028	Belongs to the TPP enzyme family
HI848_RS08175	COG0395	ABC-type sugar transport system, permease component
HI848_RS08185	COG0583	DNA-binding transcription factor activity
HI848_RS08190	COG0789	Transcriptional regulator
HI848_RS08195	COG2814	Major facilitator Superfamily
HI848_RS08240	COG0335	large ribosomal subunit rRNA binding
HI848_RS08245	COG0336	Belongs to the RNA methyltransferase TrmD family
HI848_RS08250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HI848_RS08260	COG1837	Belongs to the UPF0109 family
HI848_RS08265	COG0228	four-way junction DNA binding
HI848_RS08270	COG0431	NADPH-dependent FMN reductase
HI848_RS08275	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HI848_RS08280	COG0519	Catalyzes the synthesis of GMP from XMP
HI848_RS08285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HI848_RS08290	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HI848_RS08300	COG0745	RESPONSE REGULATOR receiver
HI848_RS08305	COG5002	protein histidine kinase activity
HI848_RS08310	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI848_RS08320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HI848_RS08345	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HI848_RS08365	COG3328	transposase activity
HI848_RS08405	COG0714	Associated with various cellular activities
HI848_RS08425	COG2217	Heavy metal translocating P-type atpase
HI848_RS08430	COG2217	Heavy metal translocating P-type atpase
HI848_RS08435	COG2608	mercury ion transmembrane transporter activity
HI848_RS08440	COG3682	Transcriptional regulator
HI848_RS08450	COG0531	amino acid
HI848_RS08455	COG2217	Heavy metal translocating P-type atpase
HI848_RS08475	COG0017	Asparaginyl-tRNA synthetase
HI848_RS08480	COG0436	Aminotransferase
HI848_RS08490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HI848_RS08490	COG1199	ATP-dependent helicase activity
HI848_RS08495	COG1278	Cold shock
HI848_RS08510	COG1686	Belongs to the peptidase S11 family
HI848_RS08520	COG0038	chloride channel
HI848_RS08535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HI848_RS08540	COG1254	Belongs to the acylphosphatase family
HI848_RS08545	COG0706	membrane insertase activity
HI848_RS08605	COG1917	Cupin 2, conserved barrel domain protein
HI848_RS08605	COG2207	Transcriptional regulator
HI848_RS08610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HI848_RS08625	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HI848_RS08625	COG0662	Cupin 2, conserved barrel domain protein
HI848_RS08630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HI848_RS08635	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HI848_RS08680	COG1216	Glycosyl transferase, family 2
HI848_RS08685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HI848_RS08705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HI848_RS08710	COG4464	protein tyrosine phosphatase activity
HI848_RS08715	COG0489	protein tyrosine kinase activity
HI848_RS08725	COG1316	TRANSCRIPTIONal
HI848_RS08735	COG0751	glycine-tRNA ligase activity
HI848_RS08740	COG0752	glycyl-tRNA synthetase alpha subunit
HI848_RS08745	COG1381	Involved in DNA repair and RecF pathway recombination
HI848_RS08750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HI848_RS08755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HI848_RS08760	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HI848_RS08770	COG1702	phosphate starvation-inducible protein PhoH
HI848_RS08775	COG1114	Component of the transport system for branched-chain amino acids
HI848_RS08785	COG1610	YqeY-like protein
HI848_RS08790	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HI848_RS08795	COG0735	belongs to the Fur family
HI848_RS08800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HI848_RS08805	COG0640	Transcriptional regulator
HI848_RS08810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HI848_RS08815	COG0492	ferredoxin-NADP+ reductase activity
HI848_RS08820	COG2723	6-phospho-beta-galactosidase activity
HI848_RS08825	COG1486	melibiose metabolic process
HI848_RS08830	COG1737	Transcriptional regulator
HI848_RS08835	COG2190	(PTS) system
HI848_RS08835	COG1263	PTS System
HI848_RS08835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS08840	COG3711	transcriptional antiterminator
HI848_RS08845	COG1132	(ABC) transporter
HI848_RS08850	COG1132	(ABC) transporter
HI848_RS08855	COG3763	UPF0154 protein
HI848_RS08860	COG1914	H( )-stimulated, divalent metal cation uptake system
HI848_RS08870	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HI848_RS08900	COG1609	Transcriptional regulator
HI848_RS08910	COG4980	gas vesicle protein
HI848_RS08920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HI848_RS08925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HI848_RS08930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HI848_RS08935	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HI848_RS08940	COG1950	PFAM Membrane protein of
HI848_RS08965	COG0704	Plays a role in the regulation of phosphate uptake
HI848_RS08970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HI848_RS08975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HI848_RS08980	COG0581	inorganic phosphate transmembrane transporter activity
HI848_RS08985	COG0573	inorganic phosphate transmembrane transporter activity
HI848_RS08990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HI848_RS08995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HI848_RS09000	COG2177	Part of the ABC transporter FtsEX involved in
HI848_RS09005	COG2884	Cell division ATP-binding protein ftsE
HI848_RS09015	COG0653	protein targeting
HI848_RS09040	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HI848_RS09045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS09055	COG1739	Uncharacterized protein family UPF0029
HI848_RS09060	COG2188	Transcriptional regulator
HI848_RS09085	COG1940	carbohydrate kinase activity
HI848_RS09105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HI848_RS09130	COG4372	Transposase
HI848_RS09135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HI848_RS09140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HI848_RS09145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HI848_RS09150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HI848_RS09155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HI848_RS09160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HI848_RS09165	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HI848_RS09170	COG0356	it plays a direct role in the translocation of protons across the membrane
HI848_RS09185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HI848_RS09190	COG2388	GCN5-related N-acetyl-transferase
HI848_RS09200	COG1957	nucleoside hydrolase
HI848_RS09225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HI848_RS09235	COG0149	triose-phosphate isomerase activity
HI848_RS09240	COG0126	phosphoglycerate kinase activity
HI848_RS09250	COG2390	Transcriptional regulator
HI848_RS09255	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HI848_RS09275	COG1595	DNA-templated transcription, initiation
HI848_RS09290	COG0095	Lipoate-protein ligase
HI848_RS09295	COG1078	dGTPase activity
HI848_RS09300	COG0561	phosphatase activity
HI848_RS09305	COG0494	nUDIX hydrolase
HI848_RS09310	COG0346	lactoylglutathione lyase activity
HI848_RS09320	COG2423	ornithine cyclodeaminase activity
HI848_RS09325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HI848_RS09330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HI848_RS09335	COG1394	ATPase activity, coupled to movement of substances
HI848_RS09340	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HI848_RS09345	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HI848_RS09350	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HI848_RS09355	COG1527	subunit (C
HI848_RS09360	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HI848_RS09365	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HI848_RS09370	COG1269	ATP hydrolysis coupled proton transport
HI848_RS09380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HI848_RS09385	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HI848_RS09395	COG4152	abc transporter atp-binding protein
HI848_RS09400	COG0322	excinuclease ABC activity
HI848_RS09405	COG3118	belongs to the thioredoxin family
HI848_RS09410	COG1193	negative regulation of DNA recombination
HI848_RS09425	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HI848_RS09440	COG1136	(ABC) transporter
HI848_RS09450	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI848_RS09485	COG1304	FMN binding
HI848_RS09500	COG0281	malic enzyme
HI848_RS09570	COG1476	TRANSCRIPTIONal
HI848_RS09580	COG4974	Belongs to the 'phage' integrase family
HI848_RS09590	COG3906	Belongs to the UPF0473 family
HI848_RS09595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HI848_RS09600	COG4472	Bacterial protein of unknown function (DUF965)
HI848_RS09630	COG4555	ABC transporter
HI848_RS09640	COG3689	TIGRFAM TIGR03943 family protein
HI848_RS09645	COG0701	Predicted permease
HI848_RS09650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI848_RS09655	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HI848_RS09660	COG0488	(ABC) transporter
HI848_RS09665	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HI848_RS09680	COG0395	ABC-type sugar transport system, permease component
HI848_RS09700	COG0662	Cupin 2, conserved barrel domain protein
HI848_RS09700	COG2207	Transcriptional regulator
HI848_RS09705	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI848_RS09715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HI848_RS09720	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HI848_RS09725	COG0584	glycerophosphoryl diester phosphodiesterase
HI848_RS09735	COG0740	serine-type endopeptidase activity
HI848_RS09740	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HI848_RS09750	COG1132	(ABC) transporter
HI848_RS09760	COG5503	Protein of unknown function (DUF1447)
HI848_RS09775	COG1278	Cold shock
HI848_RS09780	COG2003	Belongs to the UPF0758 family
HI848_RS09785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI848_RS09790	COG0285	dihydrofolate synthase activity
HI848_RS09795	COG0525	valine-tRNA ligase activity
HI848_RS09800	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HI848_RS09805	COG0301	tRNA thio-modification
HI848_RS09810	COG1104	cysteine desulfurase activity
HI848_RS09815	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HI848_RS09825	COG0561	phosphatase activity
HI848_RS09830	COG1801	Protein of unknown function DUF72
HI848_RS09850	COG3579	cysteine-type endopeptidase activity
HI848_RS09910	COG1098	S1 RNA binding domain
HI848_RS09915	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HI848_RS09925	COG0492	ferredoxin-NADP+ reductase activity
HI848_RS09930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HI848_RS09945	COG4470	Protein conserved in bacteria
HI848_RS09950	COG0737	Belongs to the 5'-nucleotidase family
HI848_RS09960	COG0590	tRNA wobble adenosine to inosine editing
HI848_RS09965	COG2508	Transcriptional regulator
HI848_RS09975	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HI848_RS09975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HI848_RS09995	COG2738	Putative neutral zinc metallopeptidase
HI848_RS10000	COG2824	Alkylphosphonate utilization operon protein PhnA
HI848_RS10005	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HI848_RS10010	COG4109	DRTGG domain
HI848_RS10015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HI848_RS10030	COG0577	efflux transmembrane transporter activity
HI848_RS10035	COG1136	(ABC) transporter
HI848_RS10045	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HI848_RS10050	COG1288	antiporter activity
HI848_RS10055	COG4821	SIS domain
HI848_RS10075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HI848_RS10080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HI848_RS10085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HI848_RS10090	COG3716	PTS system mannose fructose sorbose family IID component
HI848_RS10095	COG3715	PTS system
HI848_RS10115	COG2826	transposase and inactivated derivatives, IS30 family
HI848_RS10125	COG1132	(ABC) transporter
HI848_RS10130	COG1132	(ABC) transporter
HI848_RS10140	COG1803	Methylglyoxal synthase
HI848_RS10145	COG3842	ATPase activity
HI848_RS10155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HI848_RS10160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HI848_RS10165	COG0084	hydrolase, TatD family'
HI848_RS10170	COG0531	amino acid
HI848_RS10180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI848_RS10180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI848_RS10195	COG0675	Transposase, IS605 OrfB family
HI848_RS10200	COG4608	Belongs to the ABC transporter superfamily
HI848_RS10205	COG0444	Belongs to the ABC transporter superfamily
HI848_RS10210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HI848_RS10215	COG0601	transmembrane transport
HI848_RS10225	COG4166	transmembrane transport
HI848_RS10240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HI848_RS10245	COG1674	ftsk spoiiie
HI848_RS10245	COG1280	lysine exporter protein (LysE YggA)
HI848_RS10250	COG2723	6-phospho-beta-galactosidase activity
HI848_RS10255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI848_RS10260	COG1126	abc transporter atp-binding protein
HI848_RS10265	COG0765	amino acid transport
HI848_RS10315	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HI848_RS10325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HI848_RS10330	COG0009	L-threonylcarbamoyladenylate synthase
HI848_RS10340	COG2890	protein-(glutamine-N5) methyltransferase activity
HI848_RS10345	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HI848_RS10350	COG1435	thymidine kinase activity
HI848_RS10360	COG2226	methyltransferase
HI848_RS10365	COG0681	Belongs to the peptidase S26 family
HI848_RS10385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HI848_RS10390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HI848_RS10395	COG3442	glutamine amidotransferase
HI848_RS10405	COG0246	Mannitol dehydrogenase
HI848_RS10410	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI848_RS10415	COG2213	PTS system mannitol-specific
HI848_RS10420	COG1131	(ABC) transporter
HI848_RS10430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI848_RS10435	COG3711	transcriptional antiterminator
HI848_RS10440	COG2213	PTS system mannitol-specific
HI848_RS10445	COG1482	cell wall glycoprotein biosynthetic process
HI848_RS10460	COG1132	(ABC) transporter
HI848_RS10480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HI848_RS10485	COG0628	permease
HI848_RS10495	COG2706	6-phosphogluconolactonase activity
HI848_RS10510	COG1368	sulfuric ester hydrolase activity
HI848_RS10515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HI848_RS10520	COG2160	L-arabinose isomerase activity
HI848_RS10525	COG0235	Class ii aldolase
HI848_RS10545	COG3940	Belongs to the glycosyl hydrolase 43 family
HI848_RS10550	COG3534	alpha-L-arabinofuranosidase
HI848_RS10560	COG0395	ABC-type sugar transport system, permease component
HI848_RS10565	COG1175	transmembrane transport
HI848_RS10585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HI848_RS10590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HI848_RS10600	COG0789	Transcriptional regulator
HI848_RS10605	COG1609	Transcriptional regulator
HI848_RS10615	COG0459	protein refolding
HI848_RS10620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HI848_RS10630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS10635	COG2910	NAD(P)H-binding
HI848_RS10640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HI848_RS10655	COG5002	protein histidine kinase activity
HI848_RS10660	COG0745	RESPONSE REGULATOR receiver
HI848_RS10665	COG1307	EDD domain protein, DegV family
HI848_RS10685	COG1714	RDD family
HI848_RS10715	COG3279	Response regulator of the LytR AlgR family
HI848_RS10745	COG3448	diguanylate cyclase activity
HI848_RS10745	COG4175	Glycine betaine
HI848_RS10770	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HI848_RS10775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HI848_RS10785	COG0628	permease
HI848_RS10790	COG1285	pathogenesis
HI848_RS10795	COG0363	glucosamine-6-phosphate deaminase activity
HI848_RS10800	COG0488	(ABC) transporter
HI848_RS10805	COG2814	Major facilitator Superfamily
HI848_RS10815	COG0222	ribosome binding
HI848_RS10820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HI848_RS10825	COG0081	regulation of translation
HI848_RS10830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HI848_RS10835	COG1760	l-serine dehydratase
HI848_RS10840	COG1760	l-serine dehydratase
HI848_RS10845	COG1304	FMN binding
HI848_RS10850	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HI848_RS10855	COG0250	Participates in transcription elongation, termination and antitermination
HI848_RS10860	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HI848_RS10865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HI848_RS10880	COG1597	lipid kinase activity
HI848_RS10900	COG4585	Histidine kinase
HI848_RS10905	COG2197	response regulator
HI848_RS10915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HI848_RS10925	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HI848_RS10930	COG2226	methyltransferase
HI848_RS10935	COG3142	Participates in the control of copper homeostasis
HI848_RS10940	COG2239	Acts as a magnesium transporter
HI848_RS10945	COG0564	pseudouridine synthase activity
HI848_RS10950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HI848_RS10955	COG2357	RelA SpoT domain protein
HI848_RS10960	COG4116	CYTH
HI848_RS10980	COG4862	establishment of competence for transformation
HI848_RS10990	COG1393	Belongs to the ArsC family
HI848_RS11005	COG0419	ATPase involved in DNA repair
HI848_RS11010	COG0420	3'-5' exonuclease activity
HI848_RS11015	COG0204	Acyl-transferase
HI848_RS11020	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HI848_RS11025	COG2827	Endonuclease containing a URI domain
HI848_RS11030	COG2755	lipolytic protein G-D-S-L family
HI848_RS11030	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HI848_RS11035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI848_RS11040	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HI848_RS11045	COG0124	histidyl-tRNA synthetase
HI848_RS11050	COG0667	Aldo Keto reductase
HI848_RS11055	COG2124	cytochrome p450
HI848_RS11060	COG1490	D-aminoacyl-tRNA deacylase activity
HI848_RS11065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HI848_RS11070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HI848_RS11075	COG2264	protein methyltransferase activity
HI848_RS11085	COG2094	Belongs to the DNA glycosylase MPG family
HI848_RS11090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HI848_RS11105	COG0589	response to stress
HI848_RS11115	COG0488	(ABC) transporter
HI848_RS11120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HI848_RS11125	COG0827	DNA restriction-modification system
HI848_RS11150	COG4537	Required for transformation and DNA binding
HI848_RS11155	COG1459	type II secretion system
HI848_RS11160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HI848_RS11165	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HI848_RS11170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HI848_RS11180	COG4473	ABC transporter
HI848_RS11185	COG1131	(ABC) transporter
HI848_RS11190	COG0537	adenosine 5'-monophosphoramidase activity
HI848_RS11200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HI848_RS11210	COG3481	metal-dependent phosphohydrolase, HD sub domain
HI848_RS11215	COG4717	serine-type aminopeptidase activity
HI848_RS11220	COG0420	3'-5' exonuclease activity
HI848_RS11225	COG0561	phosphatase activity
HI848_RS11255	COG2211	Major facilitator Superfamily
HI848_RS11260	COG3507	Belongs to the glycosyl hydrolase 43 family
HI848_RS11275	COG1073	alpha beta
HI848_RS11285	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HI848_RS11290	COG1653	transport
HI848_RS11300	COG4209	transmembrane transport
HI848_RS11305	COG0395	ABC-type sugar transport system, permease component
HI848_RS11310	COG2207	Transcriptional regulator
HI848_RS11315	COG1609	Transcriptional regulator
HI848_RS11320	COG0246	Mannitol dehydrogenase
HI848_RS11325	COG2721	sulfolactate sulfo-lyase activity
HI848_RS11330	COG1904	glucuronate isomerase
HI848_RS11340	COG2755	lipolytic protein G-D-S-L family
HI848_RS11350	COG1132	(ABC) transporter
HI848_RS11355	COG3679	Belongs to the UPF0342 family
HI848_RS11360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HI848_RS11365	COG0564	pseudouridine synthase activity
HI848_RS11370	COG1940	carbohydrate kinase activity
HI848_RS11375	COG0383	alpha-mannosidase activity
HI848_RS11395	COG2207	Transcriptional regulator
HI848_RS11395	COG4753	response regulator
HI848_RS11400	COG2972	Histidine kinase
HI848_RS11410	COG1653	transport
HI848_RS11415	COG0395	ABC-type sugar transport system, permease component
HI848_RS11420	COG1175	transmembrane transport
HI848_RS11425	COG1187	pseudouridine synthase activity
HI848_RS11430	COG2244	polysaccharide biosynthetic process
HI848_RS11440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HI848_RS11445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS11460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI848_RS11460	COG3711	transcriptional antiterminator
HI848_RS11505	COG0789	Transcriptional regulator
HI848_RS11505	COG4978	Transcriptional regulator
HI848_RS11515	COG1132	(ABC) transporter
HI848_RS11525	COG0495	leucyl-tRNA aminoacylation
HI848_RS11530	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI848_RS11530	COG1388	LysM domain
HI848_RS11535	COG0671	phosphoesterase, PA-phosphatase related
HI848_RS11540	COG1242	4 iron, 4 sulfur cluster binding
HI848_RS11545	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HI848_RS11550	COG1132	(ABC) transporter
HI848_RS11555	COG1132	(ABC) transporter
HI848_RS11570	COG0477	Major facilitator Superfamily
HI848_RS11575	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HI848_RS11725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HI848_RS11730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HI848_RS11735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HI848_RS11745	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HI848_RS11750	COG0037	tRNA processing
HI848_RS11755	COG1098	S1 RNA binding domain
HI848_RS11765	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HI848_RS11770	COG2244	polysaccharide biosynthetic process
HI848_RS11775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HI848_RS11780	COG0193	aminoacyl-tRNA hydrolase activity
HI848_RS11785	COG0039	L-malate dehydrogenase activity
HI848_RS11795	COG0217	transcriptional regulatory protein
HI848_RS11820	COG1792	Involved in formation and maintenance of cell shape
HI848_RS11830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HI848_RS11835	COG1162	GTPase activity
HI848_RS11845	COG2815	serine threonine protein kinase
HI848_RS11845	COG0515	serine threonine protein kinase
HI848_RS11850	COG0631	protein serine/threonine phosphatase activity
HI848_RS11855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HI848_RS11855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HI848_RS11860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HI848_RS11865	COG0242	peptide deformylase activity
HI848_RS11870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HI848_RS11875	COG1758	RNA polymerase activity
HI848_RS11880	COG0194	GDP metabolic process
HI848_RS11890	COG1561	YicC-like family, N-terminal region
HI848_RS11900	COG1752	Esterase of the alpha-beta hydrolase superfamily
HI848_RS11915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HI848_RS11920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HI848_RS11925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HI848_RS11930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HI848_RS11935	COG1121	(ABC) transporter
HI848_RS11940	COG3443	Belongs to the bacterial solute-binding protein 9 family
HI848_RS11940	COG0803	Belongs to the bacterial solute-binding protein 9 family
HI848_RS11945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HI848_RS11950	COG0392	lysyltransferase activity
HI848_RS11950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HI848_RS11955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HI848_RS11960	COG1418	mRNA catabolic process
HI848_RS11965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HI848_RS11970	COG1058	Belongs to the CinA family
HI848_RS11970	COG1546	Belongs to the CinA family
HI848_RS11975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HI848_RS11980	COG1426	Protein conserved in bacteria
HI848_RS11985	COG0612	Peptidase, M16
HI848_RS11990	COG0612	Peptidase, M16
HI848_RS11995	COG1970	mechanosensitive ion channel activity
HI848_RS12000	COG2153	protein acetylation
HI848_RS12005	COG4466	Protein conserved in bacteria
HI848_RS12015	COG3688	RNA-binding protein containing a PIN domain
HI848_RS12020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HI848_RS12025	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HI848_RS12030	COG0215	cysteine-tRNA ligase activity
HI848_RS12035	COG1045	serine acetyltransferase
HI848_RS12040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HI848_RS12045	COG4956	integral membrane protein (PIN domain superfamily)
HI848_RS12055	COG0756	dUTP diphosphatase activity
HI848_RS12060	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HI848_RS12065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HI848_RS12080	COG2814	Major facilitator Superfamily
HI848_RS12100	COG0778	Nitroreductase
HI848_RS12110	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI848_RS12110	COG1388	LysM domain
HI848_RS12115	COG4221	oxidoreductase activity
HI848_RS12125	COG0583	DNA-binding transcription factor activity
HI848_RS12130	COG3711	transcriptional antiterminator
HI848_RS12135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS12135	COG1263	PTS System
HI848_RS12135	COG2190	(PTS) system
HI848_RS12140	COG0702	epimerase
HI848_RS12155	COG3708	Transcriptional regulator
HI848_RS12155	COG2207	Transcriptional regulator
HI848_RS12170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI848_RS12180	COG2723	6-phospho-beta-galactosidase activity
HI848_RS12185	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HI848_RS12195	COG0604	alcohol dehydrogenase
HI848_RS12200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HI848_RS12205	COG0842	Transport permease protein
HI848_RS12210	COG1131	(ABC) transporter
HI848_RS12215	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HI848_RS12220	COG0383	alpha-mannosidase activity
HI848_RS12225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI848_RS12230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI848_RS12235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI848_RS12235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI848_RS12235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI848_RS12240	COG3711	transcriptional antiterminator
HI848_RS12240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI848_RS12245	COG2205	protein histidine kinase activity
HI848_RS12250	COG0745	RESPONSE REGULATOR receiver
HI848_RS12290	COG1674	ftsk spoiiie
HI848_RS12315	COG2946	Replication initiation factor
HI848_RS12355	COG0741	lytic transglycosylase activity
HI848_RS12355	COG0791	NLP P60 protein
HI848_RS12380	COG2814	Major facilitator Superfamily
HI848_RS12385	COG3328	transposase activity
HI848_RS12395	COG3328	transposase activity
HI848_RS12405	COG3942	CHAP domain
HI848_RS12405	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI848_RS12410	COG2826	transposase and inactivated derivatives, IS30 family
HI848_RS12420	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI848_RS12435	COG2207	Transcriptional regulator
HI848_RS12435	COG3708	Transcriptional regulator
HI848_RS12470	COG0523	cobalamin synthesis protein
HI848_RS12490	COG3443	Belongs to the bacterial solute-binding protein 9 family
HI848_RS12490	COG0803	Belongs to the bacterial solute-binding protein 9 family
HI848_RS12505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HI848_RS12515	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HI848_RS12520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HI848_RS12525	COG1132	(ABC) transporter
HI848_RS12530	COG1132	(ABC) transporter
HI848_RS12540	COG1129	ABC transporter
HI848_RS12550	COG1309	transcriptional regulator
HI848_RS12585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HI848_RS12590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HI848_RS12595	COG0783	Belongs to the Dps family
HI848_RS12600	COG1070	Carbohydrate kinase
HI848_RS12605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HI848_RS12610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HI848_RS12615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI848_RS12625	COG1554	hydrolase, family 65, central catalytic
HI848_RS12630	COG0673	inositol 2-dehydrogenase activity
HI848_RS12635	COG1082	Xylose isomerase domain protein TIM barrel
HI848_RS12640	COG1063	alcohol dehydrogenase
HI848_RS12645	COG0395	ABC-type sugar transport system, permease component
HI848_RS12650	COG1175	transmembrane transport
HI848_RS12655	COG1653	transport
HI848_RS12660	COG0366	Alpha amylase catalytic
HI848_RS12665	COG1609	Transcriptional regulator
HI848_RS12670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HI848_RS12675	COG0085	RNA polymerase activity
HI848_RS12685	COG4120	Belongs to the binding-protein-dependent transport system permease family
HI848_RS12695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HI848_RS12695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HI848_RS12710	COG0142	geranyltranstransferase activity
HI848_RS12730	COG4939	FMN-binding domain protein
HI848_RS12745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HI848_RS12750	COG0826	peptidase U32
HI848_RS12755	COG0826	peptidase U32
HI848_RS12760	COG0542	response to heat
HI848_RS12765	COG4463	regulation of RNA biosynthetic process
HI848_RS12840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HI848_RS12845	COG0516	GMP reductase activity
HI848_RS12845	COG0517	IMP dehydrogenase activity
HI848_RS12855	COG0012	GTP binding
HI848_RS12860	COG4481	Protein conserved in bacteria
HI848_RS12865	COG1475	DNA binding
HI848_RS12870	COG1192	Involved in chromosome partitioning
HI848_RS12875	COG0357	Ribosomal RNA small subunit methyltransferase G
HI848_RS12880	COG0445	tRNA wobble uridine modification
HI848_RS12885	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HI848_RS12895	COG1847	R3H domain protein
HI848_RS12900	COG0706	membrane insertase activity
HI848_RS12905	COG0594	ribonuclease P activity
HI848_RS12910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HI848_RS12975	COG0629	single-stranded DNA binding
HI848_RS13020	COG4115	mRNA cleavage
HI848_RS13100	COG1609	Transcriptional regulator
HI848_RS13105	COG2723	6-phospho-beta-galactosidase activity
HI848_RS13110	COG1447	Phosphotransferase system cellobiose-specific component IIA
HI848_RS13130	COG1349	DNA-binding transcription factor activity
HI848_RS13155	COG1349	DNA-binding transcription factor activity
HI848_RS13170	COG1105	Belongs to the carbohydrate kinase PfkB family
HI848_RS13175	COG3684	Belongs to the aldolase LacD family
HI848_RS13185	COG2205	protein histidine kinase activity
HI848_RS13260	COG3328	transposase activity
HI848_RS13265	COG0582	viral genome integration into host DNA
HI848_RS13275	COG0346	lactoylglutathione lyase activity
HI848_RS13300	COG1609	Transcriptional regulator
HI848_RS13315	COG0395	ABC-type sugar transport system, permease component
HI848_RS13320	COG1486	melibiose metabolic process
HI848_RS13325	COG1653	transport
HI848_RS13330	COG1175	transmembrane transport
HI848_RS13335	COG0395	ABC-type sugar transport system, permease component
HI848_RS13345	COG0366	Alpha amylase catalytic
HI848_RS13350	COG0366	Alpha amylase catalytic
HI848_RS13375	COG0582	viral genome integration into host DNA
HI848_RS13380	COG4974	Belongs to the 'phage' integrase family
HI848_RS13410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS13410	COG2190	(PTS) system
HI848_RS13410	COG1263	PTS System
HI848_RS13415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS13415	COG1263	PTS System
HI848_RS13415	COG2190	(PTS) system
HI848_RS13420	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HI848_RS13455	COG1609	Transcriptional regulator
HI848_RS13460	COG1621	beta-fructofuranosidase activity
HI848_RS13465	COG2190	(PTS) system
HI848_RS13465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI848_RS13465	COG1263	PTS System
HI848_RS13470	COG1940	carbohydrate kinase activity
HI848_RS13505	COG4372	Transposase
HI848_RS13515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HI848_RS13530	COG3775	system Galactitol-specific IIC component
HI848_RS13550	COG3328	transposase activity
HI848_RS13640	COG3328	transposase activity
HI848_RS13665	COG4974	Belongs to the 'phage' integrase family
HI848_RS13680	COG1609	Transcriptional regulator
HI848_RS13690	COG1621	beta-fructofuranosidase activity
HI848_RS13850	COG3328	transposase activity
HI848_RS13870	COG0456	acetyltransferase
HI848_RS13900	COG3328	transposase activity
HI848_RS13915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HI848_RS13945	COG5002	protein histidine kinase activity
HI848_RS13960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HI848_RS13975	COG3842	ATPase activity
HI848_RS13985	COG0395	ABC-type sugar transport system, permease component
HI848_RS14000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HI848_RS14020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HI848_RS14035	COG1136	(ABC) transporter
HI848_RS14055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI848_RS14120	COG2207	Transcriptional regulator
HI848_RS14290	COG1783	phage Terminase large subunit
HI848_RS14365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HI848_RS14375	COG3723	Recombinational DNA repair protein, rece pathway
HI848_RS14380	COG5377	YqaJ viral recombinase family
HI848_RS14430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HI848_RS14565	COG2826	transposase and inactivated derivatives, IS30 family
HI848_RS14610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HI848_RS14630	COG1192	Involved in chromosome partitioning
HI848_RS14690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HI848_RS14695	COG2801	Transposase and inactivated derivatives
HI848_RS14830	COG0772	Belongs to the SEDS family