locus-tag	class	description
HI837_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HI837_RS00010	COG0592	DNA-directed DNA polymerase activity
HI837_RS00015	COG2501	S4 domain
HI837_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HI837_RS00025	COG0187	DNA topoisomerase II activity
HI837_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
HI837_RS00040	COG0629	single-stranded DNA binding
HI837_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HI837_RS00055	COG0359	binds to the 23S rRNA
HI837_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
HI837_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HI837_RS00080	COG0488	(ABC) transporter
HI837_RS00090	COG0028	Belongs to the TPP enzyme family
HI837_RS00165	COG2723	6-phospho-beta-galactosidase activity
HI837_RS00175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS00175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS00185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HI837_RS00185	COG0519	Catalyzes the synthesis of GMP from XMP
HI837_RS00190	COG1072	(Pantothenic acid kinase))
HI837_RS00195	COG2813	Specifically methylates the guanine in position
HI837_RS00200	COG1609	Transcriptional regulator
HI837_RS00205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HI837_RS00210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HI837_RS00215	COG0295	cytidine deaminase activity
HI837_RS00220	COG1744	ABC transporter substrate-binding protein PnrA-like
HI837_RS00225	COG3845	ABC transporter
HI837_RS00230	COG4603	Belongs to the binding-protein-dependent transport system permease family
HI837_RS00235	COG1079	Belongs to the binding-protein-dependent transport system permease family
HI837_RS00240	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HI837_RS00250	COG0813	purine-nucleoside phosphorylase activity
HI837_RS00255	COG0588	phosphoglycerate mutase activity
HI837_RS00265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HI837_RS00270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HI837_RS00275	COG0049	tRNA binding
HI837_RS00280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HI837_RS00285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HI837_RS00290	COG0051	transcription antitermination factor activity, RNA binding
HI837_RS00295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HI837_RS00300	COG0088	Forms part of the polypeptide exit tunnel
HI837_RS00305	COG0089	rRNA binding
HI837_RS00310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HI837_RS00320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HI837_RS00325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HI837_RS00330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HI837_RS00335	COG0255	Belongs to the universal ribosomal protein uL29 family
HI837_RS00340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HI837_RS00345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HI837_RS00350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HI837_RS00355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HI837_RS00360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HI837_RS00365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HI837_RS00370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HI837_RS00375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HI837_RS00380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HI837_RS00385	COG1841	ribosomal large subunit assembly
HI837_RS00390	COG0200	Binds to the 23S rRNA
HI837_RS00395	COG0201	protein transport
HI837_RS00400	COG0563	adenylate kinase activity
HI837_RS00405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HI837_RS00410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HI837_RS00415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HI837_RS00420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HI837_RS00425	COG0202	RNA polymerase activity
HI837_RS00430	COG0203	ribosomal protein L17
HI837_RS00435	COG1122	ATPase activity
HI837_RS00440	COG1122	ATPase activity
HI837_RS00450	COG0101	tRNA pseudouridine synthase activity
HI837_RS00460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HI837_RS00470	COG1461	Dihydroxyacetone kinase
HI837_RS00475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HI837_RS00480	COG0416	fatty acid biosynthetic process
HI837_RS00485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HI837_RS00500	COG4608	Belongs to the ABC transporter superfamily
HI837_RS00505	COG0601	transmembrane transport
HI837_RS00520	COG0571	ribonuclease III activity
HI837_RS00525	COG1196	nuclear chromosome segregation
HI837_RS00530	COG0561	phosphatase activity
HI837_RS00535	COG0552	protein localization to endoplasmic reticulum
HI837_RS00540	COG2918	glutathione biosynthetic process
HI837_RS00540	COG1181	Belongs to the D-alanine--D-alanine ligase family
HI837_RS00550	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HI837_RS00555	COG4605	iron ion homeostasis
HI837_RS00560	COG4604	ABC transporter, ATP-binding protein
HI837_RS00565	COG4607	ABC-type enterochelin transport system periplasmic component
HI837_RS00590	COG4886	Leucine-rich repeat (LRR) protein
HI837_RS00590	COG4932	domain protein
HI837_RS00600	COG3328	transposase activity
HI837_RS00620	COG1380	Effector of murein hydrolase LrgA
HI837_RS00640	COG1028	Short-chain dehydrogenase reductase Sdr
HI837_RS00650	COG1268	BioY protein
HI837_RS00655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HI837_RS00670	COG0561	phosphatase activity
HI837_RS00675	COG1692	metallophosphoesterase
HI837_RS00685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HI837_RS00695	COG0424	maF-like protein
HI837_RS00700	COG1263	PTS System
HI837_RS00700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS00705	COG2188	Transcriptional regulator
HI837_RS00715	COG0632	four-way junction helicase activity
HI837_RS00720	COG2255	four-way junction helicase activity
HI837_RS00730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HI837_RS00740	COG3328	transposase activity
HI837_RS00745	COG1114	Component of the transport system for branched-chain amino acids
HI837_RS00755	COG1113	amino acid transport
HI837_RS00760	COG1126	abc transporter atp-binding protein
HI837_RS00765	COG0765	amino acid transport
HI837_RS00775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HI837_RS00780	COG0110	maltose O-acetyltransferase activity
HI837_RS00785	COG1827	regulation of RNA biosynthetic process
HI837_RS00790	COG0242	peptide deformylase activity
HI837_RS00795	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HI837_RS00800	COG1185	polyribonucleotide nucleotidyltransferase activity
HI837_RS00810	COG3158	transport of potassium into the cell
HI837_RS00815	COG1253	flavin adenine dinucleotide binding
HI837_RS00820	COG0534	Mate efflux family protein
HI837_RS00830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HI837_RS00835	COG1187	pseudouridine synthase activity
HI837_RS00840	COG1011	Hydrolase
HI837_RS00845	COG0572	uridine kinase
HI837_RS00870	COG1671	Belongs to the UPF0178 family
HI837_RS00880	COG1181	Belongs to the D-alanine--D-alanine ligase family
HI837_RS00885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HI837_RS00895	COG0736	holo-[acyl-carrier-protein] synthase activity
HI837_RS00900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HI837_RS00905	COG2337	Toxic component of a toxin-antitoxin (TA) module
HI837_RS00910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HI837_RS00915	COG3321	synthase
HI837_RS00915	COG0604	alcohol dehydrogenase
HI837_RS00925	COG0531	amino acid
HI837_RS00950	COG1174	glycine betaine transport
HI837_RS00970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HI837_RS00985	COG0343	queuine tRNA-ribosyltransferase activity
HI837_RS00990	COG1862	Preprotein translocase
HI837_RS00995	COG1454	alcohol dehydrogenase
HI837_RS00995	COG1012	belongs to the aldehyde dehydrogenase family
HI837_RS01000	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HI837_RS01030	COG2207	Transcriptional regulator
HI837_RS01030	COG1917	Cupin 2, conserved barrel domain protein
HI837_RS01035	COG1070	Carbohydrate kinase
HI837_RS01040	COG4806	L-rhamnose isomerase
HI837_RS01045	COG0235	Class ii aldolase
HI837_RS01050	COG3254	rhamnose metabolic process
HI837_RS01055	COG1454	alcohol dehydrogenase
HI837_RS01060	COG1414	Transcriptional regulator
HI837_RS01065	COG0800	Aldolase
HI837_RS01075	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HI837_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
HI837_RS01090	COG1304	FMN binding
HI837_RS01105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HI837_RS01110	COG1428	Deoxynucleoside kinase
HI837_RS01125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HI837_RS01130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HI837_RS01135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HI837_RS01165	COG0824	Thioesterase
HI837_RS01170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HI837_RS01195	COG1363	Peptidase, m42
HI837_RS01200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI837_RS01205	COG0589	response to stress
HI837_RS01210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI837_RS01215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HI837_RS01220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HI837_RS01225	COG4807	Protein conserved in bacteria
HI837_RS01235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HI837_RS01250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HI837_RS01315	COG1368	sulfuric ester hydrolase activity
HI837_RS01325	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HI837_RS01335	COG0101	tRNA pseudouridine synthase activity
HI837_RS01355	COG3328	transposase activity
HI837_RS01380	COG2186	Transcriptional regulator
HI837_RS01385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS01390	COG2723	6-phospho-beta-galactosidase activity
HI837_RS01400	COG1447	Phosphotransferase system cellobiose-specific component IIA
HI837_RS01420	COG1063	alcohol dehydrogenase
HI837_RS01435	COG4716	Myosin-crossreactive antigen
HI837_RS01475	COG1113	amino acid transport
HI837_RS01500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HI837_RS01510	COG3052	prosthetic group binding
HI837_RS01575	COG1051	belongs to the nudix hydrolase family
HI837_RS01580	COG1846	Transcriptional regulator
HI837_RS01605	COG2252	PERMEase
HI837_RS01610	COG0366	Alpha amylase catalytic
HI837_RS01615	COG2723	6-phospho-beta-galactosidase activity
HI837_RS01625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS01625	COG2190	(PTS) system
HI837_RS01625	COG1263	PTS System
HI837_RS01630	COG2723	6-phospho-beta-galactosidase activity
HI837_RS01640	COG1902	pentaerythritol trinitrate reductase activity
HI837_RS01650	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI837_RS01660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HI837_RS01665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HI837_RS01670	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HI837_RS01680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HI837_RS01690	COG1937	Protein conserved in bacteria
HI837_RS01695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HI837_RS01700	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI837_RS01705	COG3973	AAA domain
HI837_RS01730	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HI837_RS01735	COG2376	Dihydroxyacetone kinase
HI837_RS01740	COG1461	Dihydroxyacetone kinase
HI837_RS01750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI837_RS01760	COG1131	(ABC) transporter
HI837_RS01765	COG1309	transcriptional regulator
HI837_RS01785	COG0531	amino acid
HI837_RS01790	COG1757	Na H antiporter
HI837_RS01795	COG1609	Transcriptional regulator
HI837_RS01805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI837_RS01815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS01815	COG1263	PTS System
HI837_RS01815	COG2190	(PTS) system
HI837_RS01840	COG3479	Phenolic acid decarboxylase
HI837_RS01845	COG1695	Transcriptional regulator
HI837_RS01855	COG2814	Major facilitator Superfamily
HI837_RS01875	COG0163	prenyltransferase activity
HI837_RS01880	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HI837_RS01890	COG0577	efflux transmembrane transporter activity
HI837_RS01890	COG1136	(ABC) transporter
HI837_RS01910	COG1811	Na channel or pump
HI837_RS01945	COG1136	(ABC) transporter
HI837_RS01965	COG3942	CHAP domain
HI837_RS01965	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI837_RS01970	COG1263	PTS System
HI837_RS01970	COG2190	(PTS) system
HI837_RS01970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS01975	COG1869	D-ribose catabolic process
HI837_RS01985	COG1609	Transcriptional regulator
HI837_RS02005	COG0366	Alpha amylase catalytic
HI837_RS02010	COG0628	permease
HI837_RS02015	COG0803	Belongs to the bacterial solute-binding protein 9 family
HI837_RS02015	COG3443	Belongs to the bacterial solute-binding protein 9 family
HI837_RS02040	COG1428	Deoxynucleoside kinase
HI837_RS02050	COG0210	DNA helicase
HI837_RS02055	COG1393	Belongs to the ArsC family
HI837_RS02060	COG1393	Belongs to the ArsC family
HI837_RS02080	COG0386	Belongs to the glutathione peroxidase family
HI837_RS02085	COG1854	S-ribosylhomocysteine lyase activity
HI837_RS02090	COG0626	cystathionine gamma-synthase activity
HI837_RS02095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HI837_RS02100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HI837_RS02110	COG0019	diaminopimelate decarboxylase activity
HI837_RS02115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HI837_RS02125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HI837_RS02130	COG2171	N-acyltransferase activity
HI837_RS02135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HI837_RS02140	COG0527	aspartate kinase activity
HI837_RS02145	COG1473	amidohydrolase
HI837_RS02150	COG0436	Aminotransferase
HI837_RS02155	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI837_RS02175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HI837_RS02180	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HI837_RS02195	COG2207	Transcriptional regulator
HI837_RS02200	COG2249	NAD(P)H dehydrogenase (quinone) activity
HI837_RS02215	COG1113	amino acid transport
HI837_RS02220	COG1121	(ABC) transporter
HI837_RS02225	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HI837_RS02240	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HI837_RS02245	COG1652	LysM domain
HI837_RS02245	COG2823	Periplasmic or secreted lipoprotein
HI837_RS02255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HI837_RS02260	COG0477	Major facilitator Superfamily
HI837_RS02270	COG1438	arginine binding
HI837_RS02285	COG1764	response to oxidative stress
HI837_RS02290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HI837_RS02295	COG1335	isochorismatase
HI837_RS02310	COG2135	peptidase activity
HI837_RS02345	COG3546	catalase activity
HI837_RS02355	COG1175	transmembrane transport
HI837_RS02360	COG0395	ABC-type sugar transport system, permease component
HI837_RS02400	COG0745	RESPONSE REGULATOR receiver
HI837_RS02405	COG2205	protein histidine kinase activity
HI837_RS02410	COG4975	Glucose uptake
HI837_RS02415	COG0531	amino acid
HI837_RS02420	COG3853	Toxic anion resistance protein (TelA)
HI837_RS02440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HI837_RS02445	COG1335	isochorismatase
HI837_RS02455	COG3590	peptidase
HI837_RS02465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HI837_RS02470	COG1104	cysteine desulfurase activity
HI837_RS02490	COG0482	sulfurtransferase activity
HI837_RS02500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HI837_RS02505	COG2814	Major facilitator Superfamily
HI837_RS02525	COG0463	Glycosyl transferase, family 2
HI837_RS02530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HI837_RS02535	COG2855	membrane
HI837_RS02545	COG0583	DNA-binding transcription factor activity
HI837_RS02550	COG0772	Belongs to the SEDS family
HI837_RS02555	COG1393	Belongs to the ArsC family
HI837_RS02560	COG0509	glycine decarboxylation via glycine cleavage system
HI837_RS02565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HI837_RS02570	COG2011	ABC-type metal ion transport system permease component
HI837_RS02575	COG1464	Belongs to the NlpA lipoprotein family
HI837_RS02585	COG0719	Fe-S assembly protein
HI837_RS02590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HI837_RS02645	COG2190	(PTS) system
HI837_RS02645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS02645	COG1263	PTS System
HI837_RS02650	COG2723	6-phospho-beta-galactosidase activity
HI837_RS02655	COG3711	transcriptional antiterminator
HI837_RS02675	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HI837_RS02690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS02690	COG1263	PTS System
HI837_RS02715	COG0800	Aldolase
HI837_RS02730	COG3775	system Galactitol-specific IIC component
HI837_RS02765	COG2188	Transcriptional regulator
HI837_RS02775	COG2222	sugar isomerase
HI837_RS02780	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HI837_RS02780	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HI837_RS02795	COG3715	PTS system
HI837_RS02800	COG3716	PTS system mannose fructose sorbose family IID component
HI837_RS02805	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HI837_RS02810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HI837_RS02840	COG3716	PTS system mannose fructose sorbose family IID component
HI837_RS02845	COG3715	PTS system
HI837_RS02850	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS02850	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS02870	COG3829	transcription factor binding
HI837_RS02885	COG3715	PTS system
HI837_RS02890	COG3716	PTS system mannose fructose sorbose family IID component
HI837_RS02905	COG1940	carbohydrate kinase activity
HI837_RS02920	COG1136	(ABC) transporter
HI837_RS02920	COG0577	efflux transmembrane transporter activity
HI837_RS02930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HI837_RS02940	COG1597	lipid kinase activity
HI837_RS02975	COG1733	regulation of RNA biosynthetic process
HI837_RS02985	COG3764	Sortase (surface protein transpeptidase)
HI837_RS02995	COG3711	transcriptional antiterminator
HI837_RS03000	COG1263	PTS System
HI837_RS03000	COG2190	(PTS) system
HI837_RS03000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS03005	COG2723	6-phospho-beta-galactosidase activity
HI837_RS03025	COG1611	Belongs to the LOG family
HI837_RS03035	COG1428	Deoxynucleoside kinase
HI837_RS03045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS03050	COG1472	Belongs to the glycosyl hydrolase 3 family
HI837_RS03060	COG2723	6-phospho-beta-galactosidase activity
HI837_RS03075	COG1368	sulfuric ester hydrolase activity
HI837_RS03085	COG0105	UTP biosynthetic process
HI837_RS03090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI837_RS03100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HI837_RS03105	COG2011	ABC-type metal ion transport system permease component
HI837_RS03110	COG1464	Belongs to the NlpA lipoprotein family
HI837_RS03115	COG1473	amidohydrolase
HI837_RS03120	COG1757	Na H antiporter
HI837_RS03130	COG1113	amino acid transport
HI837_RS03140	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HI837_RS03145	COG1929	Belongs to the glycerate kinase type-1 family
HI837_RS03150	COG0488	(ABC) transporter
HI837_RS03165	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HI837_RS03170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS03170	COG1263	PTS System
HI837_RS03175	COG1780	Probably involved in ribonucleotide reductase function
HI837_RS03185	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HI837_RS03190	COG1131	(ABC) transporter
HI837_RS03210	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HI837_RS03225	COG0346	lactoylglutathione lyase activity
HI837_RS03250	COG0561	phosphatase activity
HI837_RS03255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HI837_RS03260	COG0280	phosphate acetyltransferase
HI837_RS03265	COG0802	atpase or kinase
HI837_RS03270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HI837_RS03280	COG0708	Exodeoxyribonuclease III
HI837_RS03290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HI837_RS03315	COG1053	succinate dehydrogenase
HI837_RS03320	COG0604	alcohol dehydrogenase
HI837_RS03320	COG3321	synthase
HI837_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
HI837_RS03325	COG0702	epimerase
HI837_RS03330	COG4684	Psort location CytoplasmicMembrane, score
HI837_RS03335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HI837_RS03340	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HI837_RS03345	COG0604	alcohol dehydrogenase
HI837_RS03355	COG3842	ATPase activity
HI837_RS03360	COG1176	ABC-type spermidine putrescine transport system, permease component I
HI837_RS03365	COG1177	transmembrane transport
HI837_RS03370	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HI837_RS03375	COG3829	transcription factor binding
HI837_RS03390	COG3715	PTS system
HI837_RS03395	COG3716	PTS system mannose fructose sorbose family IID component
HI837_RS03410	COG1940	carbohydrate kinase activity
HI837_RS03455	COG0582	viral genome integration into host DNA
HI837_RS03460	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HI837_RS03470	COG0789	Transcriptional regulator
HI837_RS03480	COG0504	CTP synthase activity
HI837_RS03490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HI837_RS03495	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HI837_RS03500	COG0254	rRNA binding
HI837_RS03520	COG1349	DNA-binding transcription factor activity
HI837_RS03530	COG2814	Major facilitator Superfamily
HI837_RS03540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI837_RS03560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HI837_RS03565	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HI837_RS03570	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HI837_RS03575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HI837_RS03580	COG3870	Protein conserved in bacteria
HI837_RS03585	COG0470	DNA polymerase III
HI837_RS03590	COG1774	PSP1 C-terminal conserved region
HI837_RS03595	COG4467	Involved in initiation control of chromosome replication
HI837_RS03610	COG0602	queuosine metabolic process
HI837_RS03615	COG1328	CTP reductase activity
HI837_RS03620	COG1136	(ABC) transporter
HI837_RS03625	COG0577	efflux transmembrane transporter activity
HI837_RS03635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HI837_RS03640	COG1696	Membrane protein involved in D-alanine export
HI837_RS03645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HI837_RS03650	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HI837_RS03655	COG1363	Peptidase, m42
HI837_RS03665	COG1234	tRNA 3'-trailer cleavage
HI837_RS03670	COG0095	Lipoate-protein ligase
HI837_RS03695	COG3759	membrane
HI837_RS03700	COG0659	secondary active sulfate transmembrane transporter activity
HI837_RS03710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HI837_RS03720	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HI837_RS03835	COG3422	double-strand break repair
HI837_RS03870	COG0740	serine-type endopeptidase activity
HI837_RS04010	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HI837_RS04010	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HI837_RS04015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS04015	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS04025	COG3715	PTS system
HI837_RS04030	COG3716	PTS system mannose fructose sorbose family IID component
HI837_RS04040	COG2261	transglycosylase associated protein
HI837_RS04045	COG0006	proline dipeptidase activity
HI837_RS04050	COG1302	Protein conserved in bacteria
HI837_RS04055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HI837_RS04060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HI837_RS04065	COG1570	exodeoxyribonuclease VII activity
HI837_RS04070	COG1722	exodeoxyribonuclease VII activity
HI837_RS04080	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HI837_RS04085	COG1438	arginine binding
HI837_RS04090	COG0497	DNA recombination
HI837_RS04125	COG0768	penicillin binding
HI837_RS04160	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HI837_RS04165	COG1799	cell septum assembly
HI837_RS04175	COG2302	S4 RNA-binding domain
HI837_RS04180	COG3599	regulation of cell shape
HI837_RS04185	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HI837_RS04190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HI837_RS04210	COG0673	inositol 2-dehydrogenase activity
HI837_RS04215	COG0513	Belongs to the DEAD box helicase family
HI837_RS04220	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HI837_RS04220	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HI837_RS04225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS04230	COG1447	Phosphotransferase system cellobiose-specific component IIA
HI837_RS04235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS04295	COG1396	sequence-specific DNA binding
HI837_RS04345	COG3328	transposase activity
HI837_RS04455	COG0740	serine-type endopeptidase activity
HI837_RS04595	COG2309	aminopeptidase activity
HI837_RS04605	COG0716	FMN binding
HI837_RS04610	COG0024	Methionine aminopeptidase
HI837_RS04615	COG1295	ribonuclease BN
HI837_RS04620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HI837_RS04635	COG1215	transferase activity, transferring glycosyl groups
HI837_RS04640	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HI837_RS04650	COG1088	dTDP-glucose 4,6-dehydratase activity
HI837_RS04655	COG1091	dTDP-4-dehydrorhamnose reductase activity
HI837_RS04670	COG1682	transport, permease protein
HI837_RS04680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HI837_RS04685	COG1216	Glycosyl transferase, family 2
HI837_RS04685	COG0438	transferase activity, transferring glycosyl groups
HI837_RS04695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HI837_RS04700	COG0463	Glycosyl transferase, family 2
HI837_RS04705	COG0438	transferase activity, transferring glycosyl groups
HI837_RS04730	COG1086	Polysaccharide biosynthesis protein
HI837_RS04735	COG2089	acid synthase
HI837_RS04740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HI837_RS04750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HI837_RS04765	COG1083	cytidylyl-transferase
HI837_RS04795	COG3328	transposase activity
HI837_RS04810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HI837_RS04815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HI837_RS04825	COG4585	Histidine kinase
HI837_RS04835	COG0569	domain protein
HI837_RS04860	COG2246	polysaccharide biosynthetic process
HI837_RS04865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HI837_RS04875	COG1316	TRANSCRIPTIONal
HI837_RS04880	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HI837_RS04885	COG3397	chitin binding
HI837_RS04890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HI837_RS04895	COG2137	regulation of response to DNA damage stimulus
HI837_RS04900	COG1194	a g-specific adenine glycosylase
HI837_RS04905	COG3557	Belongs to the UPF0374 family
HI837_RS04920	COG0628	permease
HI837_RS04925	COG1253	flavin adenine dinucleotide binding
HI837_RS04930	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HI837_RS04945	COG0542	response to heat
HI837_RS04950	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS04955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HI837_RS04965	COG0438	transferase activity, transferring glycosyl groups
HI837_RS04970	COG2084	Dehydrogenase
HI837_RS04975	COG4703	Protein of unknown function (DUF1797)
HI837_RS04980	COG0322	excinuclease ABC activity
HI837_RS04985	COG1846	Transcriptional regulator
HI837_RS04990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HI837_RS05000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HI837_RS05010	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HI837_RS05020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HI837_RS05025	COG0439	Biotin carboxylase
HI837_RS05030	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HI837_RS05035	COG0825	malonyl-CoA metabolic process
HI837_RS05040	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HI837_RS05045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HI837_RS05050	COG1534	Rna-binding protein
HI837_RS05055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HI837_RS05060	COG1713	HD superfamily hydrolase involved in NAD metabolism
HI837_RS05065	COG0799	negative regulation of ribosome biogenesis
HI837_RS05070	COG2226	methyltransferase
HI837_RS05075	COG1323	Belongs to the UPF0348 family
HI837_RS05080	COG0217	transcriptional regulatory protein
HI837_RS05090	COG3973	AAA domain
HI837_RS05095	COG2217	Heavy metal translocating P-type atpase
HI837_RS05100	COG1942	4-Oxalocrotonate Tautomerase
HI837_RS05105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HI837_RS05110	COG1737	Transcriptional regulator
HI837_RS05115	COG0768	penicillin binding
HI837_RS05125	COG0561	phosphatase activity
HI837_RS05130	COG2252	PERMEase
HI837_RS05135	COG2814	Major facilitator Superfamily
HI837_RS05145	COG0587	DNA-directed DNA polymerase activity
HI837_RS05150	COG0205	6-phosphofructokinase activity
HI837_RS05160	COG0583	DNA-binding transcription factor activity
HI837_RS05170	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HI837_RS05175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HI837_RS05180	COG0745	RESPONSE REGULATOR receiver
HI837_RS05185	COG5002	protein histidine kinase activity
HI837_RS05285	COG3711	transcriptional antiterminator
HI837_RS05295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS05295	COG1263	PTS System
HI837_RS05295	COG2190	(PTS) system
HI837_RS05305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS05305	COG1263	PTS System
HI837_RS05305	COG2190	(PTS) system
HI837_RS05310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS05330	COG1349	DNA-binding transcription factor activity
HI837_RS05355	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HI837_RS05360	COG3623	hexulose-6-phosphate isomerase
HI837_RS05370	COG0456	acetyltransferase
HI837_RS05380	COG3328	transposase activity
HI837_RS05390	COG2116	formate transmembrane transporter activity
HI837_RS05400	COG1349	DNA-binding transcription factor activity
HI837_RS05405	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HI837_RS05410	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HI837_RS05420	COG3328	transposase activity
HI837_RS05435	COG2213	PTS system mannitol-specific
HI837_RS05455	COG3328	transposase activity
HI837_RS05475	COG3775	system Galactitol-specific IIC component
HI837_RS05490	COG0400	carboxylic ester hydrolase activity
HI837_RS05495	COG0346	lactoylglutathione lyase activity
HI837_RS05500	COG2188	Transcriptional regulator
HI837_RS05505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS05510	COG2723	6-phospho-beta-galactosidase activity
HI837_RS05515	COG0589	response to stress
HI837_RS05530	COG1393	Belongs to the ArsC family
HI837_RS05545	COG0351	phosphomethylpyrimidine kinase
HI837_RS05550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HI837_RS05555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI837_RS05565	COG3344	reverse transcriptase
HI837_RS05570	COG3425	synthase
HI837_RS05575	COG0183	Belongs to the thiolase family
HI837_RS05590	COG0656	L-ascorbic acid biosynthetic process
HI837_RS05610	COG0392	lysyltransferase activity
HI837_RS05610	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HI837_RS05615	COG0596	Alpha beta hydrolase
HI837_RS05620	COG0741	lytic transglycosylase activity
HI837_RS05630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI837_RS05635	COG0358	DNA primase activity
HI837_RS05640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HI837_RS05655	COG2996	Protein conserved in bacteria
HI837_RS05660	COG0735	belongs to the Fur family
HI837_RS05665	COG4974	Belongs to the 'phage' integrase family
HI837_RS05675	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HI837_RS05680	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HI837_RS05685	COG1187	pseudouridine synthase activity
HI837_RS05690	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HI837_RS05695	COG1288	antiporter activity
HI837_RS05700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HI837_RS05720	COG0514	ATP-dependent DNA helicase (RecQ)
HI837_RS05730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HI837_RS05735	COG0539	negative regulation of cytoplasmic translation
HI837_RS05740	COG1160	GTP binding
HI837_RS05745	COG0776	regulation of translation
HI837_RS05755	COG0457	Tetratricopeptide repeat
HI837_RS05760	COG5582	Belongs to the UPF0302 family
HI837_RS05765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI837_RS05770	COG1694	Mazg nucleotide pyrophosphohydrolase
HI837_RS05775	COG0617	tRNA 3'-terminal CCA addition
HI837_RS05790	COG0025	NhaP-type Na H and K H
HI837_RS05800	COG0488	(ABC) transporter
HI837_RS05805	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HI837_RS05815	COG1272	protein, Hemolysin III
HI837_RS05820	COG1307	EDD domain protein, DegV family
HI837_RS05825	COG2755	lipolytic protein G-D-S-L family
HI837_RS05830	COG4698	Protein conserved in bacteria
HI837_RS05840	COG4479	Belongs to the UPF0346 family
HI837_RS05845	COG0681	Belongs to the peptidase S26 family
HI837_RS05860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HI837_RS05865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HI837_RS05870	COG0758	DNA mediated transformation
HI837_RS05875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HI837_RS05880	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HI837_RS05885	COG4974	Belongs to the 'phage' integrase family
HI837_RS05890	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HI837_RS05895	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HI837_RS05910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HI837_RS05915	COG1832	CoA-binding protein
HI837_RS05920	COG0187	DNA topoisomerase II activity
HI837_RS05935	COG1882	Formate acetyltransferase
HI837_RS05940	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HI837_RS05945	COG1227	inorganic diphosphatase activity
HI837_RS05965	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HI837_RS05975	COG1073	alpha beta
HI837_RS05980	COG1609	Transcriptional regulator
HI837_RS05990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI837_RS06000	COG1732	Glycine betaine
HI837_RS06015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HI837_RS06025	COG1116	anion transmembrane transporter activity
HI837_RS06030	COG0084	hydrolase, TatD family'
HI837_RS06035	COG1388	LysM domain
HI837_RS06035	COG3942	CHAP domain
HI837_RS06055	COG3328	transposase activity
HI837_RS06075	COG0436	Aminotransferase
HI837_RS06095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HI837_RS06100	COG4565	transcriptional regulatory protein
HI837_RS06105	COG3290	protein histidine kinase activity
HI837_RS06110	COG3290	protein histidine kinase activity
HI837_RS06120	COG2268	Band 7 protein
HI837_RS06135	COG0673	inositol 2-dehydrogenase activity
HI837_RS06145	COG1876	peptidase activity
HI837_RS06150	COG1388	LysM domain
HI837_RS06150	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI837_RS06160	COG1653	transport
HI837_RS06165	COG1175	transmembrane transport
HI837_RS06170	COG0395	ABC-type sugar transport system, permease component
HI837_RS06180	COG0673	inositol 2-dehydrogenase activity
HI837_RS06185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HI837_RS06190	COG2233	PERMEase
HI837_RS06195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HI837_RS06200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HI837_RS06205	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HI837_RS06210	COG3344	reverse transcriptase
HI837_RS06220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HI837_RS06225	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HI837_RS06230	COG0047	phosphoribosylformylglycinamidine synthase activity
HI837_RS06235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HI837_RS06245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HI837_RS06250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HI837_RS06255	COG0138	bifunctional purine biosynthesis protein purh
HI837_RS06260	COG0151	Belongs to the GarS family
HI837_RS06265	COG4989	oxidoreductase activity
HI837_RS06275	COG2972	Histidine kinase
HI837_RS06285	COG4213	ABC transporter substrate-binding protein
HI837_RS06295	COG4214	carbohydrate transport
HI837_RS06300	COG0516	GMP reductase activity
HI837_RS06305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HI837_RS06315	COG0022	dehydrogenase e1 component
HI837_RS06335	COG4476	Belongs to the UPF0223 family
HI837_RS06340	COG0483	inositol monophosphate 1-phosphatase activity
HI837_RS06345	COG1217	gtp-binding protein TYPA
HI837_RS06350	COG0514	ATP-dependent DNA helicase (RecQ)
HI837_RS06355	COG4838	Belongs to the UPF0358 family
HI837_RS06360	COG0772	Belongs to the SEDS family
HI837_RS06365	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HI837_RS06380	COG4471	UPF0298 protein
HI837_RS06385	COG0742	ribosomal rna small subunit methyltransferase
HI837_RS06390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HI837_RS06395	COG3480	Lon protease (S16) C-terminal proteolytic domain
HI837_RS06400	COG1555	photosystem II stabilization
HI837_RS06400	COG1596	polysaccharide export
HI837_RS06415	COG2131	deaminase
HI837_RS06420	COG2333	competence protein COMEC
HI837_RS06420	COG0658	competence protein
HI837_RS06425	COG1466	dna polymerase III delta subunit
HI837_RS06430	COG0268	Binds directly to 16S ribosomal RNA
HI837_RS06440	COG2707	UPF0756 membrane protein
HI837_RS06445	COG2217	Heavy metal translocating P-type atpase
HI837_RS06450	COG1968	undecaprenyl-diphosphatase activity
HI837_RS06470	COG1666	GTP binding
HI837_RS06475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI837_RS06480	COG2151	metal-sulfur cluster biosynthetic enzyme
HI837_RS06495	COG3942	CHAP domain
HI837_RS06495	COG1388	LysM domain
HI837_RS06550	COG4990	cell redox homeostasis
HI837_RS06570	COG3104	oligopeptide transport
HI837_RS06580	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HI837_RS06585	COG1074	ATP-dependent DNA helicase activity
HI837_RS06590	COG1733	regulation of RNA biosynthetic process
HI837_RS06595	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HI837_RS06600	COG0072	phenylalanine-tRNA ligase activity
HI837_RS06600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI837_RS06610	COG1126	abc transporter atp-binding protein
HI837_RS06615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI837_RS06620	COG0765	amino acid transport
HI837_RS06625	COG0765	amino acid transport
HI837_RS06630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HI837_RS06635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HI837_RS06645	COG0517	IMP dehydrogenase activity
HI837_RS06650	COG0668	transmembrane transport
HI837_RS06655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HI837_RS06660	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HI837_RS06665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HI837_RS06695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HI837_RS06705	COG1234	tRNA 3'-trailer cleavage
HI837_RS06710	COG0300	oxidoreductase activity
HI837_RS06715	COG5416	Lipopolysaccharide assembly protein A domain
HI837_RS06720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HI837_RS06720	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HI837_RS06725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HI837_RS06735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HI837_RS06750	COG2826	transposase and inactivated derivatives, IS30 family
HI837_RS06755	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI837_RS06755	COG1388	LysM domain
HI837_RS06760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HI837_RS06765	COG0735	belongs to the Fur family
HI837_RS06770	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI837_RS06780	COG1846	Transcriptional regulator
HI837_RS06790	COG3935	DnaD domain protein
HI837_RS06795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HI837_RS06805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HI837_RS06810	COG3331	DNA recombination
HI837_RS06815	COG4474	Belongs to the UPF0398 family
HI837_RS06820	COG3599	regulation of cell shape
HI837_RS06830	COG0116	Belongs to the methyltransferase superfamily
HI837_RS06835	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HI837_RS06840	COG1418	mRNA catabolic process
HI837_RS06845	COG0156	8-amino-7-oxononanoate synthase activity
HI837_RS06850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HI837_RS06855	COG0531	amino acid
HI837_RS06870	COG0513	Belongs to the DEAD box helicase family
HI837_RS06875	COG2153	protein acetylation
HI837_RS06880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HI837_RS06885	COG4684	Psort location CytoplasmicMembrane, score
HI837_RS06895	COG0328	RNA-DNA hybrid ribonuclease activity
HI837_RS06905	COG1278	Cold shock
HI837_RS06910	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HI837_RS06925	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HI837_RS06930	COG0564	pseudouridine synthase activity
HI837_RS06940	COG2233	PERMEase
HI837_RS06945	COG0540	Belongs to the ATCase OTCase family
HI837_RS06950	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HI837_RS06955	COG0505	Belongs to the CarA family
HI837_RS06960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HI837_RS06965	COG0543	2 iron, 2 sulfur cluster binding
HI837_RS06975	COG0284	orotidine-5'-phosphate decarboxylase activity
HI837_RS07005	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HI837_RS07025	COG4120	Belongs to the binding-protein-dependent transport system permease family
HI837_RS07035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HI837_RS07070	COG0039	L-malate dehydrogenase activity
HI837_RS07090	COG3037	sugar-specific permease SgaT UlaA
HI837_RS07100	COG3711	transcriptional antiterminator
HI837_RS07110	COG0673	inositol 2-dehydrogenase activity
HI837_RS07160	COG0745	RESPONSE REGULATOR receiver
HI837_RS07165	COG5002	protein histidine kinase activity
HI837_RS07170	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HI837_RS07195	COG0351	phosphomethylpyrimidine kinase
HI837_RS07205	COG4475	Protein of unknown function (DUF436)
HI837_RS07210	COG0366	Alpha amylase catalytic
HI837_RS07225	COG1307	EDD domain protein, DegV family
HI837_RS07230	COG2244	polysaccharide biosynthetic process
HI837_RS07280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HI837_RS07285	COG0194	GDP metabolic process
HI837_RS07305	COG0765	amino acid transport
HI837_RS07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI837_RS07320	COG0167	dihydroorotate dehydrogenase activity
HI837_RS07330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HI837_RS07340	COG3833	ABC-type maltose transport systems, permease component
HI837_RS07345	COG1175	transmembrane transport
HI837_RS07350	COG2182	Extracellular solute-binding protein
HI837_RS07355	COG0366	Alpha amylase catalytic
HI837_RS07360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI837_RS07370	COG1764	response to oxidative stress
HI837_RS07375	COG1846	Transcriptional regulator
HI837_RS07380	COG0628	permease
HI837_RS07395	COG1312	Catalyzes the dehydration of D-mannonate
HI837_RS07400	COG0246	Mannitol dehydrogenase
HI837_RS07410	COG0450	alkyl hydroperoxide reductase
HI837_RS07460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HI837_RS07475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HI837_RS07490	COG0531	amino acid
HI837_RS07495	COG0004	ammonium transporteR
HI837_RS07505	COG2261	transglycosylase associated protein
HI837_RS07550	COG3655	Transcriptional regulator
HI837_RS07560	COG2261	transglycosylase associated protein
HI837_RS07580	COG1028	Short-chain dehydrogenase reductase Sdr
HI837_RS07595	COG1442	glycosyl transferase family 8
HI837_RS07600	COG1442	glycosyl transferase family 8
HI837_RS07605	COG0561	phosphatase activity
HI837_RS07630	COG1476	TRANSCRIPTIONal
HI837_RS07655	COG1278	Cold shock
HI837_RS07665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI837_RS07670	COG1312	Catalyzes the dehydration of D-mannonate
HI837_RS07690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS07695	COG3716	PTS system mannose fructose sorbose family IID component
HI837_RS07705	COG0371	Dehydrogenase
HI837_RS07720	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HI837_RS07725	COG1737	Transcriptional regulator
HI837_RS07725	COG0837	glucose binding
HI837_RS07740	COG2272	Belongs to the type-B carboxylesterase lipase family
HI837_RS07745	COG1073	alpha beta
HI837_RS07780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HI837_RS07800	COG3732	PTS system glucitol sorbitol-specific
HI837_RS07805	COG3730	PTS system glucitol sorbitol-specific
HI837_RS07815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS07815	COG3711	transcriptional antiterminator
HI837_RS07840	COG3328	transposase activity
HI837_RS07850	COG4974	Belongs to the 'phage' integrase family
HI837_RS07855	COG0582	viral genome integration into host DNA
HI837_RS07875	COG3250	beta-galactosidase activity
HI837_RS07890	COG2211	Major facilitator Superfamily
HI837_RS07900	COG1904	glucuronate isomerase
HI837_RS07905	COG1312	Catalyzes the dehydration of D-mannonate
HI837_RS07910	COG0246	Mannitol dehydrogenase
HI837_RS08035	COG2946	Replication initiation factor
HI837_RS08045	COG1674	ftsk spoiiie
HI837_RS08080	COG3328	transposase activity
HI837_RS08090	COG0481	GTPase activity
HI837_RS08110	COG0542	response to heat
HI837_RS08125	COG1597	lipid kinase activity
HI837_RS08130	COG2195	Cleaves the N-terminal amino acid of tripeptides
HI837_RS08135	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HI837_RS08140	COG2384	SAM-dependent methyltransferase
HI837_RS08155	COG1484	DNA-dependent DNA replication
HI837_RS08165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HI837_RS08175	COG0237	dephospho-CoA kinase activity
HI837_RS08180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HI837_RS08185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HI837_RS08185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HI837_RS08200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HI837_RS08205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HI837_RS08210	COG3091	SprT-like family
HI837_RS08215	COG2183	response to ionizing radiation
HI837_RS08225	COG1054	Belongs to the UPF0176 family
HI837_RS08250	COG0546	phosphoglycolate phosphatase activity
HI837_RS08255	COG0588	phosphoglycerate mutase activity
HI837_RS08310	COG4753	response regulator
HI837_RS08310	COG2207	Transcriptional regulator
HI837_RS08320	COG2972	Histidine kinase
HI837_RS08325	COG0077	Prephenate dehydratase
HI837_RS08330	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HI837_RS08335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HI837_RS08340	COG0287	Prephenate dehydrogenase
HI837_RS08345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HI837_RS08355	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HI837_RS08360	COG3250	beta-galactosidase activity
HI837_RS08375	COG1609	Transcriptional regulator
HI837_RS08385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HI837_RS08400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HI837_RS08405	COG1597	lipid kinase activity
HI837_RS08410	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HI837_RS08415	COG0154	amidase activity
HI837_RS08420	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HI837_RS08425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HI837_RS08430	COG0210	DNA helicase
HI837_RS08440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI837_RS08440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI837_RS08440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS08445	COG1105	Belongs to the carbohydrate kinase PfkB family
HI837_RS08450	COG1349	DNA-binding transcription factor activity
HI837_RS08470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HI837_RS08475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HI837_RS08480	COG0544	peptidyl-prolyl cis-trans isomerase activity
HI837_RS08490	COG1714	RDD family
HI837_RS08505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HI837_RS08510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HI837_RS08545	COG1481	regulation of sporulation
HI837_RS08550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HI837_RS08555	COG1660	Displays ATPase and GTPase activities
HI837_RS08570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HI837_RS08575	COG0556	nucleotide-excision repair
HI837_RS08580	COG0765	amino acid transport
HI837_RS08585	COG1126	abc transporter atp-binding protein
HI837_RS08590	COG0484	heat shock protein binding
HI837_RS08595	COG0443	Heat shock 70 kDa protein
HI837_RS08600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HI837_RS08605	COG1420	regulation of RNA biosynthetic process
HI837_RS08610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HI837_RS08640	COG0693	protein deglycase activity
HI837_RS08655	COG1619	proteins homologs of microcin C7 resistance protein MccF
HI837_RS08665	COG5646	InterPro IPR014922
HI837_RS08675	COG4975	Glucose uptake
HI837_RS08685	COG0196	riboflavin kinase activity
HI837_RS08690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HI837_RS08700	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HI837_RS08705	COG1175	transmembrane transport
HI837_RS08710	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HI837_RS08725	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HI837_RS08730	COG0195	Participates in both transcription termination and antitermination
HI837_RS08735	COG0779	Required for maturation of 30S ribosomal subunits
HI837_RS08740	COG2176	DNA-directed DNA polymerase activity
HI837_RS08745	COG0442	prolyl-tRNA aminoacylation
HI837_RS08750	COG0750	zinc metalloprotease
HI837_RS08755	COG4589	Belongs to the CDS family
HI837_RS08760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HI837_RS08765	COG0233	cytoplasmic translational termination
HI837_RS08770	COG0528	UMP kinase activity
HI837_RS08775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HI837_RS08780	COG0052	Belongs to the universal ribosomal protein uS2 family
HI837_RS08785	COG1438	arginine binding
HI837_RS08795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI837_RS08800	COG0018	arginyl-trna synthetase
HI837_RS08815	COG2235	arginine
HI837_RS08820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HI837_RS08830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HI837_RS08835	COG0456	acetyltransferase
HI837_RS08845	COG1214	PFAM Peptidase M22, glycoprotease
HI837_RS08850	COG1609	Transcriptional regulator
HI837_RS08855	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HI837_RS08860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HI837_RS08875	COG3189	MarR family transcriptional regulator
HI837_RS08880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HI837_RS08885	COG1940	carbohydrate kinase activity
HI837_RS08900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HI837_RS08905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HI837_RS08910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HI837_RS08915	COG1120	ATPase activity
HI837_RS08930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HI837_RS08935	COG4876	unkown
HI837_RS08940	COG0367	asparagine synthase
HI837_RS08945	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HI837_RS08955	COG1309	transcriptional regulator
HI837_RS08975	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HI837_RS08990	COG0584	glycerophosphoryl diester phosphodiesterase
HI837_RS09020	COG0166	Belongs to the GPI family
HI837_RS09025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HI837_RS09030	COG2081	HI0933 family
HI837_RS09035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HI837_RS09040	COG0710	3-dehydroquinate dehydratase activity
HI837_RS09045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HI837_RS09050	COG1368	sulfuric ester hydrolase activity
HI837_RS09070	COG5002	protein histidine kinase activity
HI837_RS09070	COG3850	Histidine kinase
HI837_RS09075	COG0745	RESPONSE REGULATOR receiver
HI837_RS09100	COG3328	transposase activity
HI837_RS09120	COG3328	transposase activity
HI837_RS09135	COG1956	GAF domain-containing protein
HI837_RS09140	COG3527	Alpha-acetolactate decarboxylase
HI837_RS09145	COG0028	Belongs to the TPP enzyme family
HI837_RS09155	COG0395	ABC-type sugar transport system, permease component
HI837_RS09165	COG0583	DNA-binding transcription factor activity
HI837_RS09170	COG0789	Transcriptional regulator
HI837_RS09175	COG2814	Major facilitator Superfamily
HI837_RS09215	COG0335	large ribosomal subunit rRNA binding
HI837_RS09220	COG0336	Belongs to the RNA methyltransferase TrmD family
HI837_RS09225	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HI837_RS09235	COG1837	Belongs to the UPF0109 family
HI837_RS09240	COG0228	four-way junction DNA binding
HI837_RS09245	COG0431	NADPH-dependent FMN reductase
HI837_RS09250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HI837_RS09255	COG0519	Catalyzes the synthesis of GMP from XMP
HI837_RS09260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HI837_RS09265	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HI837_RS09275	COG0745	RESPONSE REGULATOR receiver
HI837_RS09280	COG5002	protein histidine kinase activity
HI837_RS09285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HI837_RS09295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HI837_RS09320	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HI837_RS09375	COG0714	Associated with various cellular activities
HI837_RS09395	COG2217	Heavy metal translocating P-type atpase
HI837_RS09400	COG2217	Heavy metal translocating P-type atpase
HI837_RS09405	COG2608	mercury ion transmembrane transporter activity
HI837_RS09410	COG3682	Transcriptional regulator
HI837_RS09420	COG0531	amino acid
HI837_RS09425	COG2217	Heavy metal translocating P-type atpase
HI837_RS09445	COG0017	Asparaginyl-tRNA synthetase
HI837_RS09450	COG0436	Aminotransferase
HI837_RS09460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HI837_RS09460	COG1199	ATP-dependent helicase activity
HI837_RS09465	COG1278	Cold shock
HI837_RS09485	COG1686	Belongs to the peptidase S11 family
HI837_RS09495	COG0038	chloride channel
HI837_RS09510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HI837_RS09515	COG1254	Belongs to the acylphosphatase family
HI837_RS09520	COG0706	membrane insertase activity
HI837_RS09525	COG3684	Belongs to the aldolase LacD family
HI837_RS09530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS09530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HI837_RS09530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS09535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS09535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI837_RS09535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HI837_RS09540	COG1105	Belongs to the carbohydrate kinase PfkB family
HI837_RS09560	COG0438	transferase activity, transferring glycosyl groups
HI837_RS09560	COG0297	glycogen (starch) synthase activity
HI837_RS09570	COG1045	serine acetyltransferase
HI837_RS09580	COG0438	transferase activity, transferring glycosyl groups
HI837_RS09585	COG0438	transferase activity, transferring glycosyl groups
HI837_RS09595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HI837_RS09600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HI837_RS09610	COG4464	protein tyrosine phosphatase activity
HI837_RS09615	COG0489	protein tyrosine kinase activity
HI837_RS09620	COG3944	biosynthesis protein
HI837_RS09625	COG1316	TRANSCRIPTIONal
HI837_RS09635	COG0751	glycine-tRNA ligase activity
HI837_RS09640	COG0752	glycyl-tRNA synthetase alpha subunit
HI837_RS09645	COG1381	Involved in DNA repair and RecF pathway recombination
HI837_RS09650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HI837_RS09655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HI837_RS09660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HI837_RS09670	COG1702	phosphate starvation-inducible protein PhoH
HI837_RS09675	COG1114	Component of the transport system for branched-chain amino acids
HI837_RS09690	COG1610	YqeY-like protein
HI837_RS09695	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HI837_RS09700	COG0735	belongs to the Fur family
HI837_RS09705	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HI837_RS09710	COG0640	Transcriptional regulator
HI837_RS09715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HI837_RS09720	COG0492	ferredoxin-NADP+ reductase activity
HI837_RS09725	COG2723	6-phospho-beta-galactosidase activity
HI837_RS09730	COG1486	melibiose metabolic process
HI837_RS09735	COG1737	Transcriptional regulator
HI837_RS09745	COG3711	transcriptional antiterminator
HI837_RS09750	COG1132	(ABC) transporter
HI837_RS09755	COG1132	(ABC) transporter
HI837_RS09760	COG3763	UPF0154 protein
HI837_RS09765	COG1914	H( )-stimulated, divalent metal cation uptake system
HI837_RS09780	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HI837_RS09790	COG1609	Transcriptional regulator
HI837_RS09800	COG4980	gas vesicle protein
HI837_RS09810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HI837_RS09815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HI837_RS09820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HI837_RS09825	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HI837_RS09830	COG1950	PFAM Membrane protein of
HI837_RS09855	COG0704	Plays a role in the regulation of phosphate uptake
HI837_RS09860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HI837_RS09865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HI837_RS09870	COG0581	inorganic phosphate transmembrane transporter activity
HI837_RS09875	COG0573	inorganic phosphate transmembrane transporter activity
HI837_RS09880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HI837_RS09885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HI837_RS09890	COG2177	Part of the ABC transporter FtsEX involved in
HI837_RS09895	COG2884	Cell division ATP-binding protein ftsE
HI837_RS09905	COG0653	protein targeting
HI837_RS09920	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HI837_RS09925	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS09935	COG1739	Uncharacterized protein family UPF0029
HI837_RS09940	COG2188	Transcriptional regulator
HI837_RS09965	COG1940	carbohydrate kinase activity
HI837_RS09985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HI837_RS10000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HI837_RS10005	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HI837_RS10010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HI837_RS10015	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HI837_RS10020	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HI837_RS10025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HI837_RS10030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HI837_RS10035	COG0356	it plays a direct role in the translocation of protons across the membrane
HI837_RS10050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HI837_RS10055	COG2388	GCN5-related N-acetyl-transferase
HI837_RS10065	COG1957	nucleoside hydrolase
HI837_RS10090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HI837_RS10105	COG0149	triose-phosphate isomerase activity
HI837_RS10110	COG0126	phosphoglycerate kinase activity
HI837_RS10120	COG2390	Transcriptional regulator
HI837_RS10125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HI837_RS10145	COG1595	DNA-templated transcription, initiation
HI837_RS10160	COG0095	Lipoate-protein ligase
HI837_RS10165	COG1078	dGTPase activity
HI837_RS10170	COG0561	phosphatase activity
HI837_RS10175	COG0494	nUDIX hydrolase
HI837_RS10180	COG0346	lactoylglutathione lyase activity
HI837_RS10190	COG2423	ornithine cyclodeaminase activity
HI837_RS10195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HI837_RS10200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HI837_RS10205	COG1394	ATPase activity, coupled to movement of substances
HI837_RS10210	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HI837_RS10215	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HI837_RS10220	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HI837_RS10225	COG1527	subunit (C
HI837_RS10230	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HI837_RS10235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HI837_RS10240	COG1269	ATP hydrolysis coupled proton transport
HI837_RS10250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HI837_RS10255	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HI837_RS10265	COG4152	abc transporter atp-binding protein
HI837_RS10270	COG0322	excinuclease ABC activity
HI837_RS10275	COG3118	belongs to the thioredoxin family
HI837_RS10280	COG1193	negative regulation of DNA recombination
HI837_RS10295	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HI837_RS10310	COG1136	(ABC) transporter
HI837_RS10325	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI837_RS10355	COG1304	FMN binding
HI837_RS10365	COG0281	malic enzyme
HI837_RS10410	COG4695	Portal protein
HI837_RS10490	COG4974	Belongs to the 'phage' integrase family
HI837_RS10495	COG3906	Belongs to the UPF0473 family
HI837_RS10500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HI837_RS10505	COG4472	Bacterial protein of unknown function (DUF965)
HI837_RS10535	COG4555	ABC transporter
HI837_RS10545	COG3689	TIGRFAM TIGR03943 family protein
HI837_RS10550	COG0701	Predicted permease
HI837_RS10555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI837_RS10560	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HI837_RS10565	COG0488	(ABC) transporter
HI837_RS10570	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HI837_RS10585	COG0395	ABC-type sugar transport system, permease component
HI837_RS10605	COG0662	Cupin 2, conserved barrel domain protein
HI837_RS10605	COG2207	Transcriptional regulator
HI837_RS10610	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI837_RS10620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HI837_RS10625	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HI837_RS10630	COG0584	glycerophosphoryl diester phosphodiesterase
HI837_RS10640	COG0740	serine-type endopeptidase activity
HI837_RS10645	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HI837_RS10655	COG1132	(ABC) transporter
HI837_RS10665	COG5503	Protein of unknown function (DUF1447)
HI837_RS10675	COG1278	Cold shock
HI837_RS10680	COG2003	Belongs to the UPF0758 family
HI837_RS10685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI837_RS10690	COG0285	dihydrofolate synthase activity
HI837_RS10695	COG0525	valine-tRNA ligase activity
HI837_RS10700	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HI837_RS10705	COG0301	tRNA thio-modification
HI837_RS10710	COG1104	cysteine desulfurase activity
HI837_RS10715	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HI837_RS10725	COG0561	phosphatase activity
HI837_RS10730	COG1801	Protein of unknown function DUF72
HI837_RS10750	COG3579	cysteine-type endopeptidase activity
HI837_RS10810	COG1098	S1 RNA binding domain
HI837_RS10815	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HI837_RS10825	COG0492	ferredoxin-NADP+ reductase activity
HI837_RS10830	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HI837_RS10845	COG4470	Protein conserved in bacteria
HI837_RS10850	COG0737	Belongs to the 5'-nucleotidase family
HI837_RS10860	COG0590	tRNA wobble adenosine to inosine editing
HI837_RS10865	COG2508	Transcriptional regulator
HI837_RS10875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HI837_RS10875	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HI837_RS10890	COG2738	Putative neutral zinc metallopeptidase
HI837_RS10895	COG2824	Alkylphosphonate utilization operon protein PhnA
HI837_RS10900	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HI837_RS10905	COG4109	DRTGG domain
HI837_RS10910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HI837_RS10930	COG0577	efflux transmembrane transporter activity
HI837_RS10935	COG1136	(ABC) transporter
HI837_RS10945	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HI837_RS10950	COG1288	antiporter activity
HI837_RS10955	COG4821	SIS domain
HI837_RS10970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HI837_RS10975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HI837_RS10980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HI837_RS10985	COG3716	PTS system mannose fructose sorbose family IID component
HI837_RS10990	COG3715	PTS system
HI837_RS11015	COG1132	(ABC) transporter
HI837_RS11020	COG1132	(ABC) transporter
HI837_RS11030	COG1803	Methylglyoxal synthase
HI837_RS11035	COG3842	ATPase activity
HI837_RS11045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HI837_RS11050	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HI837_RS11055	COG0084	hydrolase, TatD family'
HI837_RS11060	COG0531	amino acid
HI837_RS11070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI837_RS11070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HI837_RS11085	COG0675	Transposase, IS605 OrfB family
HI837_RS11090	COG4608	Belongs to the ABC transporter superfamily
HI837_RS11095	COG0444	Belongs to the ABC transporter superfamily
HI837_RS11100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HI837_RS11105	COG0601	transmembrane transport
HI837_RS11115	COG4166	transmembrane transport
HI837_RS11130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HI837_RS11135	COG1674	ftsk spoiiie
HI837_RS11135	COG1280	lysine exporter protein (LysE YggA)
HI837_RS11140	COG2723	6-phospho-beta-galactosidase activity
HI837_RS11145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HI837_RS11150	COG1126	abc transporter atp-binding protein
HI837_RS11155	COG0765	amino acid transport
HI837_RS11200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HI837_RS11210	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HI837_RS11215	COG0009	L-threonylcarbamoyladenylate synthase
HI837_RS11225	COG2890	protein-(glutamine-N5) methyltransferase activity
HI837_RS11230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HI837_RS11235	COG1435	thymidine kinase activity
HI837_RS11245	COG2226	methyltransferase
HI837_RS11250	COG0681	Belongs to the peptidase S26 family
HI837_RS11270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HI837_RS11275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HI837_RS11280	COG3442	glutamine amidotransferase
HI837_RS11285	COG0246	Mannitol dehydrogenase
HI837_RS11290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS11295	COG2213	PTS system mannitol-specific
HI837_RS11300	COG1131	(ABC) transporter
HI837_RS11310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS11315	COG3711	transcriptional antiterminator
HI837_RS11320	COG2213	PTS system mannitol-specific
HI837_RS11325	COG1482	cell wall glycoprotein biosynthetic process
HI837_RS11340	COG1132	(ABC) transporter
HI837_RS11360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HI837_RS11365	COG0628	permease
HI837_RS11375	COG2706	6-phosphogluconolactonase activity
HI837_RS11390	COG1368	sulfuric ester hydrolase activity
HI837_RS11395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HI837_RS11400	COG2160	L-arabinose isomerase activity
HI837_RS11405	COG0235	Class ii aldolase
HI837_RS11425	COG3940	Belongs to the glycosyl hydrolase 43 family
HI837_RS11430	COG3534	alpha-L-arabinofuranosidase
HI837_RS11440	COG0395	ABC-type sugar transport system, permease component
HI837_RS11445	COG1175	transmembrane transport
HI837_RS11465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HI837_RS11470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HI837_RS11480	COG0789	Transcriptional regulator
HI837_RS11485	COG1609	Transcriptional regulator
HI837_RS11500	COG0459	protein refolding
HI837_RS11505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HI837_RS11515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS11520	COG2910	NAD(P)H-binding
HI837_RS11525	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HI837_RS11540	COG5002	protein histidine kinase activity
HI837_RS11545	COG0745	RESPONSE REGULATOR receiver
HI837_RS11550	COG1307	EDD domain protein, DegV family
HI837_RS11590	COG3448	diguanylate cyclase activity
HI837_RS11590	COG4175	Glycine betaine
HI837_RS11615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HI837_RS11620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HI837_RS11630	COG0628	permease
HI837_RS11635	COG1285	pathogenesis
HI837_RS11640	COG0363	glucosamine-6-phosphate deaminase activity
HI837_RS11645	COG0488	(ABC) transporter
HI837_RS11660	COG2814	Major facilitator Superfamily
HI837_RS11670	COG0222	ribosome binding
HI837_RS11675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HI837_RS11680	COG0081	regulation of translation
HI837_RS11685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HI837_RS11690	COG1760	l-serine dehydratase
HI837_RS11695	COG1760	l-serine dehydratase
HI837_RS11700	COG1304	FMN binding
HI837_RS11705	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HI837_RS11710	COG0250	Participates in transcription elongation, termination and antitermination
HI837_RS11715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HI837_RS11720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HI837_RS11735	COG1597	lipid kinase activity
HI837_RS11750	COG1131	(ABC) transporter
HI837_RS11755	COG4585	Histidine kinase
HI837_RS11760	COG2197	response regulator
HI837_RS11770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HI837_RS11780	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HI837_RS11785	COG2226	methyltransferase
HI837_RS11790	COG3142	Participates in the control of copper homeostasis
HI837_RS11795	COG2239	Acts as a magnesium transporter
HI837_RS11800	COG0564	pseudouridine synthase activity
HI837_RS11805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HI837_RS11810	COG2357	RelA SpoT domain protein
HI837_RS11815	COG4116	CYTH
HI837_RS11835	COG3328	transposase activity
HI837_RS11850	COG4862	establishment of competence for transformation
HI837_RS11855	COG1393	Belongs to the ArsC family
HI837_RS11870	COG0419	ATPase involved in DNA repair
HI837_RS11875	COG0420	3'-5' exonuclease activity
HI837_RS11880	COG0204	Acyl-transferase
HI837_RS11885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HI837_RS11890	COG2827	Endonuclease containing a URI domain
HI837_RS11895	COG2755	lipolytic protein G-D-S-L family
HI837_RS11895	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HI837_RS11900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HI837_RS11905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HI837_RS11910	COG0124	histidyl-tRNA synthetase
HI837_RS11915	COG0667	Aldo Keto reductase
HI837_RS11920	COG2124	cytochrome p450
HI837_RS11925	COG1490	D-aminoacyl-tRNA deacylase activity
HI837_RS11930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HI837_RS11935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HI837_RS11940	COG2264	protein methyltransferase activity
HI837_RS11950	COG2094	Belongs to the DNA glycosylase MPG family
HI837_RS11955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HI837_RS11970	COG0589	response to stress
HI837_RS11980	COG0488	(ABC) transporter
HI837_RS11985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HI837_RS11990	COG0827	DNA restriction-modification system
HI837_RS12015	COG4537	Required for transformation and DNA binding
HI837_RS12020	COG1459	type II secretion system
HI837_RS12025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HI837_RS12030	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HI837_RS12035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HI837_RS12045	COG4473	ABC transporter
HI837_RS12050	COG1131	(ABC) transporter
HI837_RS12055	COG0537	adenosine 5'-monophosphoramidase activity
HI837_RS12065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HI837_RS12070	COG3481	metal-dependent phosphohydrolase, HD sub domain
HI837_RS12075	COG4717	serine-type aminopeptidase activity
HI837_RS12080	COG0420	3'-5' exonuclease activity
HI837_RS12085	COG0561	phosphatase activity
HI837_RS12110	COG2211	Major facilitator Superfamily
HI837_RS12130	COG1073	alpha beta
HI837_RS12140	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HI837_RS12145	COG1653	transport
HI837_RS12155	COG4209	transmembrane transport
HI837_RS12160	COG0395	ABC-type sugar transport system, permease component
HI837_RS12165	COG2207	Transcriptional regulator
HI837_RS12170	COG1609	Transcriptional regulator
HI837_RS12175	COG0246	Mannitol dehydrogenase
HI837_RS12190	COG2721	sulfolactate sulfo-lyase activity
HI837_RS12195	COG1904	glucuronate isomerase
HI837_RS12200	COG2755	lipolytic protein G-D-S-L family
HI837_RS12210	COG1132	(ABC) transporter
HI837_RS12220	COG3679	Belongs to the UPF0342 family
HI837_RS12225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HI837_RS12230	COG0564	pseudouridine synthase activity
HI837_RS12235	COG1940	carbohydrate kinase activity
HI837_RS12240	COG0383	alpha-mannosidase activity
HI837_RS12260	COG4753	response regulator
HI837_RS12260	COG2207	Transcriptional regulator
HI837_RS12265	COG2972	Histidine kinase
HI837_RS12275	COG1653	transport
HI837_RS12280	COG0395	ABC-type sugar transport system, permease component
HI837_RS12285	COG1175	transmembrane transport
HI837_RS12290	COG1187	pseudouridine synthase activity
HI837_RS12295	COG2244	polysaccharide biosynthetic process
HI837_RS12305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HI837_RS12310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS12325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HI837_RS12325	COG3711	transcriptional antiterminator
HI837_RS12370	COG4978	Transcriptional regulator
HI837_RS12370	COG0789	Transcriptional regulator
HI837_RS12380	COG1132	(ABC) transporter
HI837_RS12390	COG0495	leucyl-tRNA aminoacylation
HI837_RS12395	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI837_RS12395	COG1388	LysM domain
HI837_RS12400	COG0671	phosphoesterase, PA-phosphatase related
HI837_RS12405	COG1242	4 iron, 4 sulfur cluster binding
HI837_RS12410	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HI837_RS12415	COG1132	(ABC) transporter
HI837_RS12420	COG1132	(ABC) transporter
HI837_RS12435	COG0477	Major facilitator Superfamily
HI837_RS12440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HI837_RS12590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HI837_RS12595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HI837_RS12600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HI837_RS12610	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HI837_RS12615	COG0037	tRNA processing
HI837_RS12620	COG1098	S1 RNA binding domain
HI837_RS12630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HI837_RS12635	COG2244	polysaccharide biosynthetic process
HI837_RS12640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HI837_RS12645	COG0193	aminoacyl-tRNA hydrolase activity
HI837_RS12650	COG0039	L-malate dehydrogenase activity
HI837_RS12660	COG0217	transcriptional regulatory protein
HI837_RS12685	COG1792	Involved in formation and maintenance of cell shape
HI837_RS12695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HI837_RS12700	COG1162	GTPase activity
HI837_RS12710	COG2815	serine threonine protein kinase
HI837_RS12710	COG0515	serine threonine protein kinase
HI837_RS12715	COG0631	protein serine/threonine phosphatase activity
HI837_RS12720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HI837_RS12720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HI837_RS12725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HI837_RS12730	COG0242	peptide deformylase activity
HI837_RS12735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HI837_RS12740	COG1758	RNA polymerase activity
HI837_RS12745	COG0194	GDP metabolic process
HI837_RS12755	COG1561	YicC-like family, N-terminal region
HI837_RS12765	COG1752	Esterase of the alpha-beta hydrolase superfamily
HI837_RS12780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HI837_RS12785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HI837_RS12790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HI837_RS12795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HI837_RS12800	COG1121	(ABC) transporter
HI837_RS12805	COG0803	Belongs to the bacterial solute-binding protein 9 family
HI837_RS12805	COG3443	Belongs to the bacterial solute-binding protein 9 family
HI837_RS12810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HI837_RS12815	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HI837_RS12815	COG0392	lysyltransferase activity
HI837_RS12820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HI837_RS12825	COG1418	mRNA catabolic process
HI837_RS12830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HI837_RS12835	COG1546	Belongs to the CinA family
HI837_RS12835	COG1058	Belongs to the CinA family
HI837_RS12840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HI837_RS12845	COG1426	Protein conserved in bacteria
HI837_RS12850	COG0612	Peptidase, M16
HI837_RS12855	COG0612	Peptidase, M16
HI837_RS12860	COG1970	mechanosensitive ion channel activity
HI837_RS12865	COG2153	protein acetylation
HI837_RS12875	COG4466	Protein conserved in bacteria
HI837_RS12885	COG3688	RNA-binding protein containing a PIN domain
HI837_RS12890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HI837_RS12895	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HI837_RS12900	COG0215	cysteine-tRNA ligase activity
HI837_RS12905	COG1045	serine acetyltransferase
HI837_RS12910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HI837_RS12915	COG4956	integral membrane protein (PIN domain superfamily)
HI837_RS12925	COG0756	dUTP diphosphatase activity
HI837_RS12930	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HI837_RS12935	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HI837_RS12970	COG0778	Nitroreductase
HI837_RS12980	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI837_RS12980	COG1388	LysM domain
HI837_RS12985	COG4221	oxidoreductase activity
HI837_RS12995	COG0583	DNA-binding transcription factor activity
HI837_RS13000	COG3711	transcriptional antiterminator
HI837_RS13005	COG2190	(PTS) system
HI837_RS13005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS13005	COG1263	PTS System
HI837_RS13010	COG0702	epimerase
HI837_RS13025	COG3708	Transcriptional regulator
HI837_RS13025	COG2207	Transcriptional regulator
HI837_RS13040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HI837_RS13050	COG0604	alcohol dehydrogenase
HI837_RS13055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HI837_RS13060	COG0842	Transport permease protein
HI837_RS13065	COG1131	(ABC) transporter
HI837_RS13075	COG2205	protein histidine kinase activity
HI837_RS13080	COG0745	RESPONSE REGULATOR receiver
HI837_RS13120	COG1674	ftsk spoiiie
HI837_RS13130	COG1674	ftsk spoiiie
HI837_RS13145	COG2946	Replication initiation factor
HI837_RS13200	COG0791	NLP P60 protein
HI837_RS13200	COG0741	lytic transglycosylase activity
HI837_RS13235	COG3942	CHAP domain
HI837_RS13235	COG1705	Flagellar rod assembly protein muramidase FlgJ
HI837_RS13240	COG0446	pyridine nucleotide-disulphide oxidoreductase
HI837_RS13260	COG2207	Transcriptional regulator
HI837_RS13260	COG3708	Transcriptional regulator
HI837_RS13320	COG3443	Belongs to the bacterial solute-binding protein 9 family
HI837_RS13320	COG0803	Belongs to the bacterial solute-binding protein 9 family
HI837_RS13335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HI837_RS13345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HI837_RS13350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HI837_RS13355	COG1132	(ABC) transporter
HI837_RS13360	COG1132	(ABC) transporter
HI837_RS13370	COG1129	ABC transporter
HI837_RS13380	COG1309	transcriptional regulator
HI837_RS13410	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HI837_RS13415	COG1082	Xylose isomerase domain protein TIM barrel
HI837_RS13420	COG0673	inositol 2-dehydrogenase activity
HI837_RS13435	COG1012	belongs to the aldehyde dehydrogenase family
HI837_RS13445	COG3718	enzyme involved in inositol metabolism
HI837_RS13450	COG3962	Belongs to the TPP enzyme family
HI837_RS13455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HI837_RS13460	COG1609	Transcriptional regulator
HI837_RS13485	COG1378	Sugar-specific transcriptional regulator TrmB
HI837_RS13515	COG4974	Belongs to the 'phage' integrase family
HI837_RS13520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HI837_RS13525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HI837_RS13535	COG0783	Belongs to the Dps family
HI837_RS13540	COG1070	Carbohydrate kinase
HI837_RS13545	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HI837_RS13550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HI837_RS13555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HI837_RS13565	COG1554	hydrolase, family 65, central catalytic
HI837_RS13570	COG0673	inositol 2-dehydrogenase activity
HI837_RS13575	COG1082	Xylose isomerase domain protein TIM barrel
HI837_RS13580	COG1063	alcohol dehydrogenase
HI837_RS13585	COG0395	ABC-type sugar transport system, permease component
HI837_RS13590	COG1175	transmembrane transport
HI837_RS13595	COG1653	transport
HI837_RS13600	COG0366	Alpha amylase catalytic
HI837_RS13605	COG1609	Transcriptional regulator
HI837_RS13610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HI837_RS13615	COG0085	RNA polymerase activity
HI837_RS13625	COG4120	Belongs to the binding-protein-dependent transport system permease family
HI837_RS13635	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HI837_RS13635	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HI837_RS13650	COG0142	geranyltranstransferase activity
HI837_RS13670	COG4939	FMN-binding domain protein
HI837_RS13685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HI837_RS13690	COG0826	peptidase U32
HI837_RS13695	COG0826	peptidase U32
HI837_RS13700	COG0542	response to heat
HI837_RS13705	COG4463	regulation of RNA biosynthetic process
HI837_RS13780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HI837_RS13785	COG0516	GMP reductase activity
HI837_RS13785	COG0517	IMP dehydrogenase activity
HI837_RS13795	COG0012	GTP binding
HI837_RS13800	COG4481	Protein conserved in bacteria
HI837_RS13805	COG1475	DNA binding
HI837_RS13810	COG1192	Involved in chromosome partitioning
HI837_RS13815	COG0357	Ribosomal RNA small subunit methyltransferase G
HI837_RS13820	COG0445	tRNA wobble uridine modification
HI837_RS13825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HI837_RS13835	COG1847	R3H domain protein
HI837_RS13840	COG0706	membrane insertase activity
HI837_RS13845	COG0594	ribonuclease P activity
HI837_RS13850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HI837_RS14015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HI837_RS14015	COG1754	DNA topoisomerase type I activity
HI837_RS14020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HI837_RS14175	COG3328	transposase activity
HI837_RS14195	COG3775	system Galactitol-specific IIC component
HI837_RS14210	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HI837_RS14220	COG4372	Transposase
HI837_RS14255	COG1940	carbohydrate kinase activity
HI837_RS14260	COG2190	(PTS) system
HI837_RS14260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS14260	COG1263	PTS System
HI837_RS14265	COG1621	beta-fructofuranosidase activity
HI837_RS14270	COG1609	Transcriptional regulator
HI837_RS14305	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HI837_RS14310	COG2190	(PTS) system
HI837_RS14310	COG1263	PTS System
HI837_RS14310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS14315	COG1263	PTS System
HI837_RS14315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HI837_RS14315	COG2190	(PTS) system
HI837_RS14335	COG4974	Belongs to the 'phage' integrase family
HI837_RS14345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HI837_RS14355	COG3684	Belongs to the aldolase LacD family
HI837_RS14360	COG2222	sugar isomerase
HI837_RS14365	COG2188	Transcriptional regulator
HI837_RS14380	COG3328	transposase activity
HI837_RS14395	COG3328	transposase activity
HI837_RS14400	COG5002	protein histidine kinase activity
HI837_RS14415	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HI837_RS14430	COG3842	ATPase activity
HI837_RS14440	COG0395	ABC-type sugar transport system, permease component
HI837_RS14455	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HI837_RS14475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HI837_RS14490	COG1136	(ABC) transporter
HI837_RS14510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HI837_RS14545	COG0582	viral genome integration into host DNA
HI837_RS14570	COG4372	Transposase
HI837_RS14595	COG3328	transposase activity
HI837_RS14605	COG0464	growth
HI837_RS14625	COG0456	acetyltransferase
HI837_RS14680	COG1192	Involved in chromosome partitioning
HI837_RS14805	COG1940	carbohydrate kinase activity
HI837_RS14815	COG0395	ABC-type sugar transport system, permease component
HI837_RS14820	COG1175	transmembrane transport
HI837_RS14830	COG4372	Transposase
HI837_RS14850	COG1609	Transcriptional regulator
HI837_RS14890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HI837_RS14920	COG3976	FMN-binding domain protein
HI837_RS14920	COG0431	NADPH-dependent FMN reductase
HI837_RS14920	COG1053	succinate dehydrogenase
HI837_RS15030	COG1598	PFAM Uncharacterised protein family UPF0150
HI837_RS15075	COG0542	response to heat
HI837_RS15315	COG3764	Sortase (surface protein transpeptidase)
HI837_RS15350	COG1674	ftsk spoiiie
HI837_RS15480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HI837_RS15535	COG0456	acetyltransferase
HI837_RS15545	COG2226	methyltransferase
HI837_RS15580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HI837_RS15585	COG2801	Transposase and inactivated derivatives
HI837_RS15685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HI837_RS15765	COG0772	Belongs to the SEDS family
HI837_RS15865	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)