locus-tag	class	description
HC353_RS00010	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HC353_RS00020	ENOG4105CK1	PTS System
HC353_RS00025	ENOG4108RYK	Nad-dependent epimerase dehydratase
HC353_RS00030	ENOG4105Q2H	domain protein
HC353_RS00045	ENOG4105BZU	Histidine kinase
HC353_RS00050	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HC353_RS00055	ENOG4105EPR	degv family
HC353_RS00210	ENOG4105KWI	UPF0339 protein
HC353_RS00370	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HC353_RS00380	ENOG4108IJ7	Glycine betaine
HC353_RS00405	ENOG41067VN	Glutaredoxin
HC353_RS00410	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HC353_RS00430	ENOG4105ETZ	PTS System
HC353_RS00435	ENOG4105DAS	pts system
HC353_RS00440	ENOG4105UP7	3-epimerase
HC353_RS00445	ENOG4105DM4	PTS System
HC353_RS00450	ENOG4108YRF	PTS System
HC353_RS00455	ENOG4105DM4	PTS System
HC353_RS00460	ENOG4108YRF	PTS System
HC353_RS00480	ENOG4105EP8	Glycosyl Hydrolase Family 88
HC353_RS00500	ENOG4105C02	permease
HC353_RS00505	ENOG4105KT7	mgtC SapB transporter
HC353_RS00510	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HC353_RS00515	ENOG4105C5H	ABC transporter
HC353_RS00530	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HC353_RS00535	ENOG4108VZM	50s ribosomal protein L10
HC353_RS00540	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HC353_RS00545	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HC353_RS00555	ENOG4105EJQ	L-serine dehydratase
HC353_RS00570	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HC353_RS00580	ENOG4107FTN	50S ribosomal protein L33
HC353_RS00595	ENOG4109050	May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG)
HC353_RS00600	ENOG4105C7H	Helicase, RecD TraA family
HC353_RS00610	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
HC353_RS00620	ENOG4106N3A	copper homeostasis protein cutc
HC353_RS00625	ENOG4105CJW	magnesium transporter
HC353_RS00630	ENOG4105EMS	pseudouridine synthase
HC353_RS00635	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HC353_RS00645	ENOG4105MIX	Adenylate cyclase
HC353_RS00665	ENOG4108SQ7	Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis
HC353_RS00670	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
HC353_RS00685	ENOG4105EYH	Exonuclease
HC353_RS00690	ENOG4107RFY	SbcCD D subunit
HC353_RS00695	ENOG4105F6E	Acyl-transferase
HC353_RS00700	ENOG41060K3	Methyltransferase
HC353_RS00705	ENOG4105VC4	domain protein
HC353_RS00710	ENOG4105EXC	Acyl-transferase
HC353_RS00715	ENOG4107AYK	membrAne
HC353_RS00720	ENOG4105C9M	aspartyl-trna synthetase
HC353_RS00725	ENOG4105CUT	histidyl-tRNA synthetase
HC353_RS00730	ENOG4105CPC	Aldo Keto reductase
HC353_RS00740	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HC353_RS00745	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HC353_RS00750	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HC353_RS00755	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HC353_RS00765	ENOG4108VX5	3-methyladenine DNA glycosylase
HC353_RS00770	ENOG4105D1H	recombination factor protein RarA
HC353_RS00785	ENOG4107YZX	Universal stress protein
HC353_RS00790	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
HC353_RS00820	ENOG4106855	Competence protein
HC353_RS00840	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HC353_RS00860	ENOG4105K59	histidine triad (HIT) protein
HC353_RS00870	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HC353_RS00875	ENOG4105EQI	Metal Dependent Phosphohydrolase
HC353_RS00880	ENOG4106D4I	domain protein
HC353_RS00885	ENOG4107VRP	DNA repair exonuclease
HC353_RS00915	ENOG4105CT4	transporter
HC353_RS00920	ENOG4105DSG	hydrolase family 43
HC353_RS00935	ENOG4105NTD	Inherit from COG: Hydrolase
HC353_RS00945	ENOG4105F5H	Glycosyl Hydrolase Family 88
HC353_RS00965	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HC353_RS00970	ENOG41075H3	AraC family transcriptional regulator
HC353_RS00975	ENOG4107KJX	Transcriptional regulator
HC353_RS00980	ENOG4107QZW	Altronate oxidoreductase
HC353_RS00985	ENOG4105CTX	dehydratase
HC353_RS00990	ENOG4105D2H	Uronic isomerase
HC353_RS01005	ENOG4105BZ1	(ABC) transporter
HC353_RS01010	ENOG4105WZB	UPF0342 protein
HC353_RS01015	ENOG4105BZ4	penicillin-binding protein
HC353_RS01020	ENOG4108YBP	pseudouridine synthase
HC353_RS01025	ENOG4105EVU	fructokinase
HC353_RS01030	ENOG4105C8I	hydrolase, family 38
HC353_RS01050	ENOG4105EQD	regulatoR
HC353_RS01055	ENOG4105C2F	Histidine kinase
HC353_RS01070	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HC353_RS01095	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HC353_RS01110	ENOG4105CK1	PTS System
HC353_RS01125	ENOG4105EMD	TRANSCRIPTIONal
HC353_RS01145	ENOG4105C8T	Leucyl-tRNA synthetase
HC353_RS01155	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HC353_RS01160	ENOG4105N5T	Radical SAM Protein
HC353_RS01170	ENOG4105BZ1	(ABC) transporter
HC353_RS01175	ENOG4105BZ1	(ABC) transporter
HC353_RS01190	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HC353_RS01195	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HC353_RS01345	ENOG4105CRK	lysyL-tRNA synthetase
HC353_RS01350	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HC353_RS01355	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HC353_RS01365	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HC353_RS01370	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HC353_RS01375	ENOG41060GV	RNA binding s1 domain protein
HC353_RS01385	ENOG41082I2	s4 domain protein
HC353_RS01395	ENOG4108JA2	transcriptioN-repair coupling factor
HC353_RS01400	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HC353_RS01405	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HC353_RS01415	ENOG4105CDY	transcriptional regulatory protein
HC353_RS01440	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HC353_RS01450	ENOG4105DJV	ribulose-phosphate 3-epimerase
HC353_RS01455	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HC353_RS01460	ENOG4105D9P	serine threonine protein kinase
HC353_RS01465	ENOG4108ZF3	Phosphatase
HC353_RS01470	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HC353_RS01475	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HC353_RS01480	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HC353_RS01485	ENOG4105C25	Primosomal protein n'
HC353_RS01490	ENOG4105ZAD	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HC353_RS01495	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HC353_RS01505	ENOG4105DSJ	YicC domain protein
HC353_RS01530	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HC353_RS01535	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HC353_RS01540	ENOG4105DFT	pur operon repressor
HC353_RS01550	ENOG4105FDK	ABC transporter
HC353_RS01555	ENOG4105DSE	periplasmic solute binding protein
HC353_RS01560	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HC353_RS01570	ENOG4105II7	pyrroline-5-carboxylate reductase
HC353_RS01575	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HC353_RS01580	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HC353_RS01585	ENOG4105CEV	competence damage-inducible protein
HC353_RS01590	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HC353_RS01610	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HC353_RS01615	ENOG4107YB6	acetyltransferase, (GNAT) family
HC353_RS01620	ENOG4105W42	Veg protein
HC353_RS01630	ENOG4105M0M	Tetracycline resistance protein
HC353_RS01635	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HC353_RS01640	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HC353_RS01645	ENOG4105C8N	cysteinyl-tRNA synthetase
HC353_RS01650	ENOG4105D7W	serine acetyltransferase
HC353_RS01655	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HC353_RS01660	ENOG4105CTP	PilT protein domain protein
HC353_RS01670	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HC353_RS01675	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HC353_RS01680	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HC353_RS01695	ENOG4105DXB	Major Facilitator superfamily
HC353_RS01705	ENOG41081I9	integral membrane protein
HC353_RS01715	ENOG4108TVJ	Nitroreductase
HC353_RS01730	ENOG4107X35	defense response to bacterium
HC353_RS01745	ENOG4105CI1	PTS System
HC353_RS01750	ENOG4105ECR	NmrA family
HC353_RS01765	ENOG41086D8	Transcriptional regulator
HC353_RS01775	ENOG4105CMG	Carbohydrate kinase
HC353_RS01780	ENOG4105DRS	transport system, permease
HC353_RS01795	ENOG4105DSG	hydrolase family 43
HC353_RS01800	ENOG4105C93	Xylose Isomerase
HC353_RS01805	ENOG4105E2R	ROK family
HC353_RS01845	ENOG4105EC2	ftsk spoIIIe
HC353_RS01850	ENOG4108MGT	Required for secretion of EsxA and EsxB
HC353_RS01870	ENOG410646G	Proteins of 100 residues with WXG
HC353_RS01885	ENOG4108UMN	azlc family
HC353_RS01895	ENOG4105CIS	alcohol dehydrogenase
HC353_RS01905	ENOG4105E3A	(ABC) transporter
HC353_RS01910	ENOG4105DA5	(ABC) transporter
HC353_RS01915	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HC353_RS01945	ENOG4108UJD	30S ribosomal protein S9
HC353_RS01950	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HC353_RS01955	ENOG4105HUF	DNA protection during starvation protein
HC353_RS01960	ENOG4105CMG	Carbohydrate kinase
HC353_RS01965	ENOG4106A3R	peptidase
HC353_RS01970	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HC353_RS01980	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HC353_RS01985	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HC353_RS01995	ENOG4105C7J	ABC transporter, permease
HC353_RS02005	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HC353_RS02025	ENOG4105DC8	reductase
HC353_RS02030	ENOG4105CFP	Peptidase U32
HC353_RS02035	ENOG4105XYU	peptidase (U32 family)
HC353_RS02040	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HC353_RS02045	ENOG4105KEX	transcriptional regulator, ctsr
HC353_RS02120	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HC353_RS02125	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HC353_RS02135	ENOG4105C3G	gtp-binding protein
HC353_RS02140	ENOG4105VDK	protein, conserved in bacteria
HC353_RS02145	ENOG4105FA0	parb-like partition protein
HC353_RS02150	ENOG4107QJE	Chromosome Partitioning Protein
HC353_RS02155	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HC353_RS02160	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HC353_RS02165	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HC353_RS02180	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HC353_RS02185	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HC353_RS02190	ENOG4105VG0	50S ribosomal protein l34
HC353_RS02195	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HC353_RS02200	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HC353_RS02205	ENOG410848D	S4 domain protein YaaA
HC353_RS02210	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HC353_RS02215	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HC353_RS02225	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HC353_RS02230	ENOG4108UUM	single-stranded DNA-binding protein
HC353_RS02235	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HC353_RS02245	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HC353_RS02250	ENOG4105CDU	Replicative dna helicase
HC353_RS02260	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HC353_RS02270	ENOG4105C5H	ABC transporter
HC353_RS02280	ENOG4105C7K	acetolactate synthase
HC353_RS02330	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HC353_RS02335	ENOG4105CS9	pantothenic acid kinase
HC353_RS02340	ENOG4107Y49	methyltransferase
HC353_RS02350	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HC353_RS02355	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
HC353_RS02360	ENOG4105KG3	cytidine deaminase
HC353_RS02365	ENOG4105DIH	basic membrane
HC353_RS02370	ENOG4108JQ9	ABC transporter
HC353_RS02375	ENOG4105UIB	(ABC) transporter
HC353_RS02385	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
HC353_RS02405	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HC353_RS02415	ENOG4105E66	phosphoriboisomerase A
HC353_RS02420	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HC353_RS02425	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HC353_RS02430	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HC353_RS02435	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HC353_RS02440	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HC353_RS02445	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HC353_RS02450	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HC353_RS02455	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HC353_RS02460	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC353_RS02470	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HC353_RS02475	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HC353_RS02480	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HC353_RS02485	ENOG41082SA	50s ribosomal protein l29
HC353_RS02490	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HC353_RS02495	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HC353_RS02500	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HC353_RS02505	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC353_RS02510	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HC353_RS02515	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HC353_RS02520	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HC353_RS02525	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HC353_RS02530	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HC353_RS02535	ENOG4105VPB	50S ribosomal protein L30
HC353_RS02540	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HC353_RS02545	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HC353_RS02550	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HC353_RS02555	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HC353_RS02560	ENOG41067V7	50S ribosomal protein L36
HC353_RS02565	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HC353_RS02570	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HC353_RS02575	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HC353_RS02580	ENOG4108ZT0	50S ribosomal protein l17
HC353_RS02585	ENOG4108JJB	ABC transporter
HC353_RS02590	ENOG4108JJB	ABC transporter
HC353_RS02600	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HC353_RS02610	ENOG4105VB9	50S ribosomal protein l28
HC353_RS02620	ENOG4105DP4	dak2 domain fusion protein ylov
HC353_RS02625	ENOG4105CB5	ATP-dependent DNA helicase recG
HC353_RS02630	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HC353_RS02635	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HC353_RS02645	ENOG4108JQ7	(ABC) transporter
HC353_RS02650	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HC353_RS02655	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HC353_RS02675	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HC353_RS02680	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HC353_RS02685	ENOG410667J	hydrolase
HC353_RS02690	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HC353_RS02695	ENOG4105D9M	gamma-glutamylcysteine synthetase
HC353_RS02705	ENOG4105DHS	permease protein
HC353_RS02710	ENOG4105CM4	permease protein
HC353_RS02715	ENOG4108IPW	abc transporter atp-binding protein
HC353_RS02745	ENOG4105E98	transcriptional regulator DeoR family
HC353_RS02750	ENOG4105VCP	PTS System
HC353_RS02755	ENOG4105CK1	PTS System
HC353_RS02760	ENOG4105CS2	ec 3.2.1.21
HC353_RS02780	ENOG4105D2M	Aldolase
HC353_RS02805	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HC353_RS02810	ENOG4105VAW	lrga family
HC353_RS02815	ENOG41067MG	lrgb family
HC353_RS02830	ENOG4105CHR	reductase
HC353_RS02840	ENOG4105VKD	bioY protein
HC353_RS02845	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HC353_RS02865	ENOG4105D48	metallophosphoesterase
HC353_RS02875	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HC353_RS02880	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HC353_RS02885	ENOG4108Z03	MAF-like protein
HC353_RS02890	ENOG4105C5Y	PTS System
HC353_RS02895	ENOG4107414	GntR family transcriptional regulator
HC353_RS02905	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HC353_RS02910	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HC353_RS02920	ENOG4105KJF	protein tyrosine phosphatase
HC353_RS02940	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HC353_RS02950	ENOG4105C85	amino acid
HC353_RS02955	ENOG4105CDA	abc transporter atp-binding protein
HC353_RS02960	ENOG4105E5Q	amino acid AbC transporter
HC353_RS02970	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HC353_RS02975	ENOG4108UW5	maltose o-acetyltransferase
HC353_RS02980	ENOG4108Z3G	3H domain protein
HC353_RS02995	ENOG4107YB9	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HC353_RS03000	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HC353_RS03005	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HC353_RS03015	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HC353_RS03020	ENOG4105C37	(CBS) domain
HC353_RS03035	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HC353_RS03040	ENOG4105I08	Pseudouridine synthase
HC353_RS03050	ENOG4105DBI	uridine monophosphokinase
HC353_RS03070	ENOG4107XJU	UPF0178 protein
HC353_RS03085	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HC353_RS03090	ENOG4105C1J	atp-dependent rna helicase
HC353_RS03095	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HC353_RS03100	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HC353_RS03105	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
HC353_RS03110	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HC353_RS03115	ENOG4108JA1	polyketide synthase
HC353_RS03125	ENOG4105C0X	amino acid
HC353_RS03130	ENOG4105R40	Glycine betaine carnitine choline
HC353_RS03150	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HC353_RS03165	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HC353_RS03170	ENOG4105VIE	preprotein translocase, subunit YajC
HC353_RS03175	ENOG4105C0A	alcohol dehydrogenase
HC353_RS03180	ENOG4105F5H	Glycosyl Hydrolase Family 88
HC353_RS03185	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HC353_RS03200	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
HC353_RS03210	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
HC353_RS03225	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HC353_RS03230	ENOG4105ZMH	deoxynucleoside kinase
HC353_RS03245	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HC353_RS03250	ENOG4105VJV	50s ribosomal protein L35
HC353_RS03255	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HC353_RS03260	ENOG4105CID	antiterminator
HC353_RS03265	ENOG4105C5Y	PTS System
HC353_RS03275	ENOG4105C4X	radical SAM domain protein
HC353_RS03320	ENOG41082UD	thioesterase Superfamily protein
HC353_RS03325	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HC353_RS03335	ENOG410838F	Glycosyl transferase family 2
HC353_RS03345	ENOG4105CN9	Peptidase m42 family protein
HC353_RS03355	ENOG4107YZX	Universal stress protein
HC353_RS03360	ENOG4108VDD	TRNA binding domain protein
HC353_RS03365	ENOG4105C0H	protease
HC353_RS03370	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HC353_RS03385	ENOG41082GB	PTS system galactitol-specific transporter subunit IIA
HC353_RS03390	ENOG4105DT3	PTS system, galactitol-specific IIc component
HC353_RS03395	ENOG4105K18	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity)
HC353_RS03400	ENOG4105D2N	Aldolase
HC353_RS03495	ENOG4107Y5K	Resolvase
HC353_RS03505	ENOG4107YVC	modification (methylase)
HC353_RS03515	ENOG4105D5G	Transposase
HC353_RS03520	ENOG4107BMA	Transglycosylase associated protein
HC353_RS03525	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HC353_RS03550	ENOG4105EVU	fructokinase
HC353_RS03555	ENOG4105ETE	Transcriptional regulator (LacI family
HC353_RS03560	ENOG4108HKT	sucrose-6-phosphate hydrolase
HC353_RS03565	ENOG4105C5Y	PTS System
HC353_RS03570	ENOG4105CG3	alpha amylase, catalytic region
HC353_RS03600	ENOG4107QV7	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)
HC353_RS03625	ENOG4105CZC	PTS system ascorbate-specific transporter subunit IIC
HC353_RS03650	ENOG4105CPC	Aldo Keto reductase
HC353_RS03655	ENOG4105JXH	GntR family transcriptional regulator
HC353_RS03660	ENOG4105CK1	PTS System
HC353_RS03665	ENOG4105CS2	ec 3.2.1.21
HC353_RS03675	ENOG4105VCP	PTS System
HC353_RS03680	ENOG4105CK1	PTS System
HC353_RS03695	ENOG4105E2A	Dehydrogenase
HC353_RS03705	ENOG4105CCI	Myosin-Cross-Reactive Antigen
HC353_RS03740	ENOG4105C85	amino acid
HC353_RS03775	ENOG4105WSE	Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity)
HC353_RS03785	ENOG4105PSI	phosphoribosyl-dephospho-CoA transferase
HC353_RS03835	ENOG4105D2N	Aldolase
HC353_RS03850	ENOG4108U05	Transcriptional regulator
HC353_RS03875	ENOG4105C7N	Xanthine uracil vitamin C permease
HC353_RS03880	ENOG4105CG3	alpha amylase, catalytic region
HC353_RS03890	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HC353_RS03900	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HC353_RS03910	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HC353_RS03915	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HC353_RS03920	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HC353_RS03925	ENOG4105C98	muts2 protein
HC353_RS03930	ENOG4108UKJ	Cdp-alcohol phosphatidyltransferase
HC353_RS03940	ENOG4105VPX	protein, conserved in bacteria
HC353_RS03945	ENOG4105WZW	rhodanese family
HC353_RS03950	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HC353_RS03955	ENOG4105EEM	helicase
HC353_RS03980	ENOG4105VDH	Dihydroxyacetone kinase
HC353_RS03985	ENOG4105CMT	Dihydroxyacetone kinase
HC353_RS03990	ENOG4108UTZ	Dihydroxyacetone kinase
HC353_RS04020	ENOG4105IJJ	transcriptional regulator, crp fnr family
HC353_RS04025	ENOG4105DIM	ABC transporter
HC353_RS04030	ENOG4105CIG	ABC transporter
HC353_RS04035	ENOG4108JGH	Tetr family transcriptional regulator
HC353_RS04055	ENOG4105E5D	amino acid
HC353_RS04060	ENOG4105DFD	Na H antiporter
HC353_RS04090	ENOG4105FKQ	transcriptional regulator
HC353_RS04100	ENOG4107URF	beta-phospho-glucomutase
HC353_RS04110	ENOG4105CI1	PTS System
HC353_RS04135	ENOG4105PY6	Phenolic acid decarboxylase
HC353_RS04140	ENOG4105U3E	Transcriptional regulator
HC353_RS04165	ENOG41062SP	
HC353_RS04170	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HC353_RS04175	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HC353_RS04185	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HC353_RS04185	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HC353_RS04195	ENOG4105BZU	Histidine kinase
HC353_RS04205	ENOG4108UQV	Membrane
HC353_RS04240	ENOG4105C19	ABC transporter
HC353_RS04250	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HC353_RS04255	ENOG4108S4A	n-acetylmuramoyl-l-alanine amidase
HC353_RS04260	ENOG4105C5Y	PTS System
HC353_RS04265	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HC353_RS04275	ENOG4105ETE	Transcriptional regulator (LacI family
HC353_RS04295	ENOG4105CG3	alpha amylase, catalytic region
HC353_RS04305	ENOG4105DSE	periplasmic solute binding protein
HC353_RS04330	ENOG4105ZMH	deoxynucleoside kinase
HC353_RS04340	ENOG4105ENA	helicase
HC353_RS04345	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
HC353_RS04350	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
HC353_RS04370	ENOG4108V06	Glutathione peroxidase
HC353_RS04375	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HC353_RS04380	ENOG4105C28	cystathionine
HC353_RS04385	ENOG4105C6T	cysteine synthase
HC353_RS04390	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HC353_RS04395	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HC353_RS04405	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HC353_RS04410	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HC353_RS04420	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HC353_RS04425	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HC353_RS04430	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HC353_RS04435	ENOG4105CFH	Aspartokinase
HC353_RS04440	ENOG4105CH2	amidohydrolase
HC353_RS04445	ENOG4105CHM	Aminotransferase
HC353_RS04450	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HC353_RS04465	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HC353_RS04470	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HC353_RS04475	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HC353_RS04485	ENOG4108R6W	Transcriptional regulator, ARAC family
HC353_RS04490	ENOG4108K2R	Glutathione-regulated potassium-efflux system ancillary protein
HC353_RS04510	ENOG4105DIK	(ABC) transporter
HC353_RS04515	ENOG4105CC5	ABC transporter
HC353_RS04520	ENOG4105DSE	periplasmic solute binding protein
HC353_RS04530	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HC353_RS04535	ENOG4108I7Y	domain protein
HC353_RS04545	ENOG4107VFR	oxidoreductase
HC353_RS04550	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HC353_RS04565	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
HC353_RS04580	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HC353_RS04590	ENOG4105D3W	isochorismatase
HC353_RS04615	ENOG4105WEF	catalase
HC353_RS04625	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HC353_RS04630	ENOG4105DRS	transport system, permease
HC353_RS04640	ENOG4105D1E	Undecaprenyl pyrophosphate phosphatase
HC353_RS04670	ENOG4105CJZ	response regulator
HC353_RS04675	ENOG4105EWM	Histidine kinase
HC353_RS04680	ENOG4105CSC	Glucose uptake protein
HC353_RS04685	ENOG4105CUB	amino acid
HC353_RS04690	ENOG4105CDW	Resistance protein
HC353_RS04710	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HC353_RS04730	ENOG4105C9K	Endothelin-converting enzyme 1
HC353_RS04740	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HC353_RS04745	ENOG4105C3J	Cysteine desulfurase
HC353_RS04795	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HC353_RS04800	ENOG4105D5Q	Arginine ornithine antiporter
HC353_RS04805	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HC353_RS04810	ENOG4105C6X	Major Facilitator
HC353_RS04830	ENOG4105CKK	Glycosyl transferase, family 2
HC353_RS04835	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HC353_RS04840	ENOG4105HMI	Membrane
HC353_RS04860	ENOG41080E8	Transcriptional regulator, Spx MgsR family
HC353_RS04865	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HC353_RS04870	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HC353_RS04875	ENOG4108UMI	ABC transporter, permease
HC353_RS04880	ENOG4105D01	(LipO)protein
HC353_RS04890	ENOG4105JRK	feS assembly protein SufD
HC353_RS04895	ENOG4105C9B	Cysteine desulfurase
HC353_RS04900	ENOG4108UNV	SUF system FeS assembly protein, NifU family
HC353_RS04905	ENOG4105DIW	FeS assembly protein SUFB
HC353_RS04975	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HC353_RS05000	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HC353_RS05015	ENOG4108YG4	
HC353_RS05020	ENOG4106ZEE	Diacylglycerol kinase
HC353_RS05075	ENOG4105F27	Major Facilitator
HC353_RS05080	ENOG4105KVH	Transcriptional regulator
HC353_RS05090	ENOG4108Z6X	(sortase) family
HC353_RS05095	ENOG4105CID	antiterminator
HC353_RS05100	ENOG4105C5Y	PTS System
HC353_RS05105	ENOG4105CS2	ec 3.2.1.21
HC353_RS05130	ENOG4105ZMH	deoxynucleoside kinase
HC353_RS05140	ENOG4105CK1	PTS System
HC353_RS05155	ENOG4105CS2	ec 3.2.1.21
HC353_RS05170	ENOG4105E0M	Sulfatase
HC353_RS05185	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HC353_RS05195	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HC353_RS05200	ENOG4108UMI	ABC transporter, permease
HC353_RS05205	ENOG4105D01	(LipO)protein
HC353_RS05210	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
HC353_RS05215	ENOG4105DFD	Na H antiporter
HC353_RS05235	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HC353_RS05240	ENOG4105BZW	Glycerate kinase
HC353_RS05245	ENOG4105C5H	ABC transporter
HC353_RS05260	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HC353_RS05265	ENOG4105C5Y	PTS System
HC353_RS05270	ENOG4105MTF	NrdI protein
HC353_RS05275	ENOG4105D5Q	Arginine ornithine antiporter
HC353_RS05280	ENOG4108TU7	Inherit from COG: (ABC) transporter
HC353_RS05285	ENOG4105CJ1	ABC, transporter
HC353_RS05305	ENOG4105C19	ABC transporter
HC353_RS05320	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
HC353_RS05335	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HC353_RS05360	ENOG410667J	hydrolase
HC353_RS05365	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HC353_RS05370	ENOG4108IJ2	phosphate acetyltransferase
HC353_RS05375	ENOG4105K8N	protein family UPF0079, ATPase
HC353_RS05380	ENOG4108MK9	spermidine N(1)-acetyltransferase
HC353_RS05385	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HC353_RS05390	ENOG4105CGK	Exodeoxyribonuclease III
HC353_RS05395	ENOG4105EP9	oxidoreductase
HC353_RS05400	ENOG4105D4A	Cell wall formation (By similarity)
HC353_RS05425	ENOG4107EFR	Flavocytochrome c
HC353_RS05440	ENOG4105FH5	Membrane
HC353_RS05445	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HC353_RS05465	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HC353_RS05470	ENOG4105F38	ABC transporter, permease
HC353_RS05475	ENOG4105D38	putrescine abc transporter
HC353_RS05480	ENOG4107RUE	extracellular solute-binding protein family 1
HC353_RS05515	ENOG4105DY9	regulatoR
HC353_RS05525	ENOG4105BZ1	(ABC) transporter
HC353_RS05540	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HC353_RS05545	ENOG4105C5H	ABC transporter
HC353_RS05550	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
HC353_RS05555	ENOG4105XXY	Thioredoxin
HC353_RS05560	ENOG4108PJD	permease
HC353_RS05565	ENOG4108NNR	transporter substrate-binding protein
HC353_RS05595	ENOG4105VBH	UPF0297 protein
HC353_RS05600	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HC353_RS05605	ENOG4105VPH	UPF0473 protein
HC353_RS05625	ENOG4105C6K	Malic enzyme
HC353_RS05665	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HC353_RS05675	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HC353_RS05695	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HC353_RS05710	ENOG4105C98	muts2 protein
HC353_RS05715	ENOG4105K63	Thioredoxin
HC353_RS05720	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HC353_RS05725	ENOG4108IUX	(ABC) transporter
HC353_RS05735	ENOG4105DMC	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3
HC353_RS05800	ENOG4105M6F	mutator MutT protein
HC353_RS05805	ENOG410667J	hydrolase
HC353_RS05810	ENOG4105DCI	Phosphohydrolase
HC353_RS05815	ENOG4105JGI	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity)
HC353_RS05825	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
HC353_RS05830	ENOG4105JVQ	RNA Polymerase
HC353_RS05835	ENOG4108P49	AntiSigma factor
HC353_RS05865	ENOG4105CJ1	ABC, transporter
HC353_RS05875	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HC353_RS05890	ENOG4105BZA	Phosphoglycerate kinase
HC353_RS05895	ENOG4105CP7	Triose-phosphate isomerase
HC353_RS05935	ENOG410830R	acetyltransferase
HC353_RS05940	ENOG4105XZU	Preprotein translocase, subunit SecG
HC353_RS05950	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HC353_RS06005	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HC353_RS06015	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HC353_RS06025	ENOG41066F8	ROK family
HC353_RS06055	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HC353_RS06065	ENOG4105VZJ	PTS System
HC353_RS06085	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HC353_RS06095	ENOG4105CAK	Cell division ATP-binding protein ftsE
HC353_RS06100	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HC353_RS06105	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HC353_RS06110	ENOG4105CVA	phosphate
HC353_RS06115	ENOG4105C8U	phosphate abc transporter
HC353_RS06120	ENOG4105E2Z	phosphate ABC transporter (Permease
HC353_RS06125	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HC353_RS06130	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HC353_RS06135	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HC353_RS06160	ENOG41086DT	Membrane protein of unknown function
HC353_RS06165	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
HC353_RS06170	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HC353_RS06175	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HC353_RS06180	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HC353_RS06200	ENOG4105ETE	Transcriptional regulator (LacI family
HC353_RS06245	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HC353_RS06255	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
HC353_RS06260	ENOG4105VXM	UPF0154 protein
HC353_RS06265	ENOG4105BZ1	(ABC) transporter
HC353_RS06270	ENOG4105BZ1	(ABC) transporter
HC353_RS06275	ENOG4105CID	antiterminator
HC353_RS06295	ENOG4106KNT	transcriptional regulator
HC353_RS06300	ENOG4105F8D	glycoside hydrolase family 4
HC353_RS06305	ENOG4105CS2	ec 3.2.1.21
HC353_RS06310	ENOG4105C3M	thioredoxin reductase
HC353_RS06320	ENOG4105KTU	Transcriptional regulator, arsr family
HC353_RS06325	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HC353_RS06330	ENOG4105N80	Ferric uptake regulator, Fur family
HC353_RS06335	ENOG4105VCC	30S ribosomal protein S21
HC353_RS06340	ENOG4105KTH	gatB Yqey
HC353_RS06345	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HC353_RS06350	ENOG4105C9A	Phoh family
HC353_RS06360	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HC353_RS06365	ENOG4107YR5	Diacylglycerol kinase
HC353_RS06370	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HC353_RS06375	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
HC353_RS06380	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
HC353_RS06385	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HC353_RS06395	ENOG4108KGH	TRANSCRIPTIONal
HC353_RS06400	ENOG4105HTX	biosynthesis protein
HC353_RS06405	ENOG4107YJ4	chain length determinant protein
HC353_RS06410	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
HC353_RS06420	ENOG4105D3Q	Sugar transferase
HC353_RS06425	ENOG4105DMT	epimerase dehydratase
HC353_RS06435	ENOG4105C5E	polysaccharide biosynthesis protein
HC353_RS06445	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HC353_RS06460	ENOG4107S6X	Glycosyl transferase, family 2
HC353_RS06465	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HC353_RS06480	ENOG4105DE4	1-phosphofructokinase
HC353_RS06485	ENOG4105DM4	PTS System
HC353_RS06490	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HC353_RS06495	ENOG4105D2M	Aldolase
HC353_RS06500	ENOG4107XQC	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity)
HC353_RS06505	ENOG410855V	Acylphosphatase
HC353_RS06510	ENOG4108RWN	rrna methyltransferase
HC353_RS06525	ENOG4107R4J	Chloride channel
HC353_RS06555	ENOG4105VEQ	Cold shock protein
HC353_RS06560	ENOG4105DVT	helicase
HC353_RS06570	ENOG4105CHM	Aminotransferase
HC353_RS06575	ENOG4105C5S	asparaginyl-tRNA synthetase
HC353_RS06600	ENOG4105C59	p-type ATPase
HC353_RS06605	ENOG4105E5D	amino acid
HC353_RS06650	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HC353_RS06675	ENOG4105CVA	phosphate
HC353_RS06680	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HC353_RS06685	ENOG4105DZW	Dipeptidase
HC353_RS06690	ENOG4105BZU	Histidine kinase
HC353_RS06695	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HC353_RS06705	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
HC353_RS06710	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC353_RS06715	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HC353_RS06720	ENOG4105NAE	bifunctional deaminase-reductase domain protein
HC353_RS06725	ENOG4108YYH	Nadph-dependent fmn reductase
HC353_RS06730	ENOG41067QW	Transcriptional regulator
HC353_RS06740	ENOG4105DA5	(ABC) transporter
HC353_RS06750	ENOG4105K5M	30s ribosomal protein S16
HC353_RS06755	ENOG4105VB6	UPF0109 protein
HC353_RS06765	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HC353_RS06770	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HC353_RS06775	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HC353_RS06790	ENOG4107FQX	Alpha-acetolactate decarboxylase
HC353_RS06795	ENOG4108ZGC	gaf domain protein
HC353_RS06870	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HC353_RS06875	ENOG4105BZU	Histidine kinase
HC353_RS06895	ENOG4105DR4	Methyltransferase
HC353_RS06900	ENOG4105FF2	Type I DHQase
HC353_RS06905	ENOG4108Z66	YbaK ebsC protein
HC353_RS06910	ENOG4105CBX	hi0933 family
HC353_RS06915	ENOG4107R37	Glutamate dehydrogenase
HC353_RS06920	ENOG4107QYV	phosphohexose isomerase
HC353_RS06925	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HC353_RS06940	ENOG41067QW	Transcriptional regulator
HC353_RS07000	ENOG4107QHE	Choloylglycine hydrolase
HC353_RS07025	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
HC353_RS07035	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
HC353_RS07055	ENOG4107Z3H	Transcriptional regulator, TetR family
HC353_RS07065	ENOG4105CAQ	asparagine synthetase
HC353_RS07070	ENOG4105NRR	Uncharacterized protein conserved in bacteria (DUF2188)
HC353_RS07075	ENOG4105WDJ	50S ribosomal protein L33
HC353_RS07090	ENOG4105E0A	ABC, transporter
HC353_RS07095	ENOG4105DQ5	transport system permease protein
HC353_RS07100	ENOG4105EHG	Permease protein
HC353_RS07105	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HC353_RS07120	ENOG4105DKQ	ROK family
HC353_RS07125	ENOG4105WZW	rhodanese family
HC353_RS07130	ENOG4105K78	MarR family Transcriptional regulator
HC353_RS07145	ENOG4105CMR	udp-glucose 4-epimerase
HC353_RS07150	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
HC353_RS07155	ENOG4105CQ4	Transcriptional regulator
HC353_RS07160	ENOG41072GX	Peptidase M22 Glycoprotease
HC353_RS07170	ENOG410801F	ribosomal-protein-alanine acetyltransferase
HC353_RS07175	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HC353_RS07180	ENOG4108QV3	biosynthesis protein
HC353_RS07190	ENOG4105CEU	Arginine dihydrolase
HC353_RS07200	ENOG4105C5B	carbamate kinase
HC353_RS07205	ENOG4105C75	arginyL-tRNA synthetase
HC353_RS07215	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HC353_RS07220	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
HC353_RS07225	ENOG4105CE9	30S ribosomal protein S2
HC353_RS07230	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HC353_RS07235	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HC353_RS07240	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HC353_RS07245	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HC353_RS07250	ENOG4105KNE	Phosphatidate cytidylyltransferase
HC353_RS07255	ENOG4105DZP	Membrane-associated zinc metalloprotease
HC353_RS07260	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HC353_RS07265	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HC353_RS07270	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HC353_RS07275	ENOG4105CHV	Transcription elongation factor NusA
HC353_RS07280	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
HC353_RS07295	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HC353_RS07305	ENOG4107QRI	Phosphoketolase
HC353_RS07310	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HC353_RS07315	ENOG4105DTN	riboflavin biosynthesis protein ribF
HC353_RS07320	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HC353_RS07330	ENOG41090XM	Early upstream open reading frame
HC353_RS07345	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HC353_RS07355	ENOG4105CI1	PTS System
HC353_RS07360	ENOG4105F8D	glycoside hydrolase family 4
HC353_RS07365	ENOG4108Q3X	Transcriptional regulator
HC353_RS07375	ENOG4108V4B	ThiJ pfpI
HC353_RS07435	ENOG4105CSA	Coproporphyrinogen iii oxidase
HC353_RS07440	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HC353_RS07445	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC353_RS07450	ENOG4105CFG	Acts as a chaperone (By similarity)
HC353_RS07455	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HC353_RS07470	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HC353_RS07475	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HC353_RS07480	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HC353_RS07490	ENOG4105D4T	Citrate transporter
HC353_RS07495	ENOG4105EQX	glucarate dehydratase
HC353_RS07500	ENOG4105BZW	Glycerate kinase
HC353_RS07505	ENOG4105CDA	abc transporter atp-binding protein
HC353_RS07510	ENOG4105EAD	ABC transporter
HC353_RS07515	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HC353_RS07520	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HC353_RS07530	ENOG4105CG9	aspartate racemase
HC353_RS07535	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HC353_RS07540	ENOG4105CHW	UPF0052 protein
HC353_RS07545	ENOG4105CIE	May be required for sporulation (By similarity)
HC353_RS07575	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HC353_RS07590	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HC353_RS07605	ENOG4105VK3	rdd domain containing protein
HC353_RS07615	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HC353_RS07620	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HC353_RS07625	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HC353_RS07645	ENOG4105E98	transcriptional regulator DeoR family
HC353_RS07650	ENOG4105DE4	1-phosphofructokinase
HC353_RS07655	ENOG4105DM4	PTS System
HC353_RS07660	ENOG4105CMQ	Chloride channel
HC353_RS07665	ENOG4105C4R	Atp-dependent dna helicase
HC353_RS07670	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HC353_RS07675	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HC353_RS07680	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HC353_RS07685	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HC353_RS07690	ENOG4105CBD	Diacylglycerol kinase
HC353_RS07695	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HC353_RS07705	ENOG4105BZ1	(ABC) transporter
HC353_RS07715	ENOG4108Z5V	transcriptional regulator, merr family
HC353_RS07725	ENOG4105F2M	alpha beta hydrolase fold-3 domain protein
HC353_RS07735	ENOG4105DME	alpha-galactosidase
HC353_RS07740	ENOG4105CNT	hydrolase family 2
HC353_RS07745	ENOG4105IKJ	beta-galactosidase small subunit
HC353_RS07750	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
HC353_RS07760	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HC353_RS07770	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HC353_RS07775	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HC353_RS07780	ENOG4105CQC	Prephenate dehydratase
HC353_RS07785	ENOG4105C2F	Histidine kinase
HC353_RS07790	ENOG4105EQD	regulatoR
HC353_RS07835	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HC353_RS07860	ENOG4105C72	UPF0176 protein
HC353_RS07875	ENOG410906U	SprT-like
HC353_RS07880	ENOG4107DB1	DUF218 domain
HC353_RS07885	ENOG4105DFU	Cell wall formation (By similarity)
HC353_RS07895	ENOG4105HFZ	Membrane
HC353_RS07900	ENOG4105C2M	dna polymerase I
HC353_RS07905	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HC353_RS07910	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HC353_RS07920	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HC353_RS07945	ENOG4105EGD	dinuclear metal center protein, YbgI family
HC353_RS07950	ENOG4105D42	Cleaves the N-terminal amino acid of tripeptides (By similarity)
HC353_RS07970	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HC353_RS07990	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HC353_RS08010	ENOG4105VEQ	Cold shock protein
HC353_RS08015	ENOG41080HT	Transcriptional regulator, arsr family
HC353_RS08065	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HC353_RS08070	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
HC353_RS08095	ENOG4107XM9	(LipO)protein
HC353_RS08100	ENOG4105EBR	Carboxylesterase
HC353_RS08115	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HC353_RS08120	ENOG4105VEQ	Cold shock protein
HC353_RS08135	ENOG4105TIV	Cryptic phage CTXphi transcriptional repressor RstR
HC353_RS08165	ENOG4108KP7	hydrolase
HC353_RS08170	ENOG4105X1N	Glycosyl transferase family 8
HC353_RS08175	ENOG4105X1N	Glycosyl transferase family 8
HC353_RS08190	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HC353_RS08210	ENOG4107BMA	Transglycosylase associated protein
HC353_RS08230	ENOG4105VMP	Transcriptional regulator
HC353_RS08245	ENOG4108WCX	response regulator
HC353_RS08280	ENOG4107BMA	Transglycosylase associated protein
HC353_RS08285	ENOG4105BZU	Histidine kinase
HC353_RS08290	ENOG4105E5D	amino acid
HC353_RS08305	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HC353_RS08320	ENOG4107XC4	flavin reductase domain protein, FMN-binding
HC353_RS08335	ENOG4108RCF	TRANSCRIPTIONal
HC353_RS08340	ENOG4107RVG	penicillin-binding protein
HC353_RS08365	ENOG4105D3R	alkyl hydroperoxide reductase
HC353_RS08380	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HC353_RS08395	ENOG4106F5Q	Membrane
HC353_RS08400	ENOG4105K56	Transcriptional regulator
HC353_RS08420	ENOG4108IUK	alpha amylase, catalytic
HC353_RS08425	ENOG4107FKK	extracellular solute-binding protein family 1
HC353_RS08430	ENOG4105D56	permease protein
HC353_RS08435	ENOG4105EG2	ABC transporter, permease
HC353_RS08440	ENOG4108VP7	maltodextrose utilization protein MalA
HC353_RS08445	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HC353_RS08455	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
HC353_RS08465	ENOG4107XKZ	Amino acid ABC superfamily ATP binding cassette transporter binding protein
HC353_RS08470	ENOG4105E5Q	amino acid AbC transporter
HC353_RS08490	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HC353_RS08495	ENOG4105D9N	nucleoside
HC353_RS08550	ENOG4105EPR	degv family
HC353_RS08570	ENOG4108UIC	UPF0340 protein
HC353_RS08610	ENOG4107KM7	Heat induced stress protein YflT
HC353_RS08615	ENOG4105US7	Histidine kinase
HC353_RS08670	ENOG4105D9R	oxidoreductase
HC353_RS08680	ENOG4105ETD	TRANSCRIPTIONal
HC353_RS08690	ENOG4105CZC	PTS system ascorbate-specific transporter subunit IIC
HC353_RS08725	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HC353_RS08755	ENOG4108RCF	TRANSCRIPTIONal
HC353_RS08760	ENOG4105E2X	shikimate dehydrogenase
HC353_RS08765	ENOG4105D5T	phosphonate abc transporter
HC353_RS08770	ENOG4105C7J	ABC transporter, permease
HC353_RS08805	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HC353_RS08815	ENOG4107R1S	catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine
HC353_RS08820	ENOG4105F3R	pts system mannose fructose sorbose family iid
HC353_RS08825	ENOG4105ETZ	PTS System
HC353_RS08850	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
HC353_RS08855	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HC353_RS08860	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HC353_RS08865	ENOG4105CD3	dihydroorotase
HC353_RS08870	ENOG4105CXT	aspartate transcarbamylase
HC353_RS08885	ENOG4105C34	Pseudouridine synthase
HC353_RS08890	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HC353_RS08905	ENOG4105CKU	formyltetrahydrofolate synthetase
HC353_RS08910	ENOG4105VEQ	Cold shock protein
HC353_RS08915	ENOG41075Z0	
HC353_RS08920	ENOG4105VND	Ribonuclease
HC353_RS08935	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HC353_RS08945	ENOG4105C1J	atp-dependent rna helicase
HC353_RS08960	ENOG4105CFC	Transporter
HC353_RS08970	ENOG4107R7I	amino acid
HC353_RS08975	ENOG4105EXW	epimerase dehydratase
HC353_RS08980	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HC353_RS08990	ENOG4105CTD	carboxy-peptidase
HC353_RS08995	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HC353_RS09005	ENOG4105XWG	Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)
HC353_RS09010	ENOG4108UKS	UPF0398 protein
HC353_RS09015	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
HC353_RS09020	ENOG4105BZ4	penicillin-binding protein
HC353_RS09025	ENOG4105CSM	endonuclease III
HC353_RS09040	ENOG4108INS	Transcriptional regulator
HC353_RS09050	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HC353_RS09055	ENOG4105G5W	regulator Fur family
HC353_RS09060	ENOG4105C6T	cysteine synthase
HC353_RS09065	ENOG4107X35	defense response to bacterium
HC353_RS09080	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HC353_RS09090	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HC353_RS09095	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HC353_RS09100	ENOG41067VP	Protein of unknown function (DUF1049)
HC353_RS09105	ENOG4108IXY	short-chain dehydrogenase reductase
HC353_RS09110	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HC353_RS09120	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC353_RS09125	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HC353_RS09145	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HC353_RS09150	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HC353_RS09155	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HC353_RS09160	ENOG4105D8X	mechanosensitive ion channel
HC353_RS09175	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HC353_RS09180	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HC353_RS09185	ENOG4105DRP	amino acid AbC transporter
HC353_RS09190	ENOG4105EAD	ABC transporter
HC353_RS09195	ENOG4105CT1	(ABC) transporter
HC353_RS09200	ENOG4105CDA	abc transporter atp-binding protein
HC353_RS09215	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HC353_RS09220	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HC353_RS09230	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HC353_RS09235	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HC353_RS09240	ENOG4105DUX	Transporter
HC353_RS09315	ENOG4105VRS	hydrolase family 18
HC353_RS09340	ENOG4105VG1	fes assembly suf system protein
HC353_RS09345	ENOG4107AYK	membrAne
HC353_RS09350	ENOG4108VPT	UPF0234 protein
HC353_RS09370	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HC353_RS09375	ENOG4105C59	p-type ATPase
HC353_RS09380	ENOG4108VMM	UPF0756 membrane protein
HC353_RS09390	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HC353_RS09395	ENOG4105TQK	DNA polymerase iii, delta' subunit
HC353_RS09400	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HC353_RS09405	ENOG4108UK2	deaminase
HC353_RS09410	ENOG4105KQC	Competence protein
HC353_RS09415	ENOG41063PX	domain protein
HC353_RS09420	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HC353_RS09425	ENOG4106H78	methyltransferase
HC353_RS09430	ENOG4105WUC	UPF0298 protein
HC353_RS09445	ENOG4108JIJ	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)
HC353_RS09450	ENOG4105CNI	cell division protein FtsW
HC353_RS09455	ENOG4105ZPI	UPF0358 protein
HC353_RS09460	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HC353_RS09465	ENOG4105CI3	gtp-binding protein typa
HC353_RS09470	ENOG4105ECY	inositol monophosphatase
HC353_RS09475	ENOG4105WBI	UPF0223 protein
HC353_RS09490	ENOG4105C7S	Dehydrogenase
HC353_RS09495	ENOG4105CPP	Dehydrogenase, E1 component
HC353_RS09500	ENOG4107RUY	(E1 component), alpha subunit
HC353_RS09510	ENOG4107SJ1	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity)
HC353_RS09515	ENOG4108HWW	ABC transporter
HC353_RS09525	ENOG4105DFW	ABC transporter
HC353_RS09535	ENOG4105C2F	Histidine kinase
HC353_RS09540	ENOG4108VAC	response regulator
HC353_RS09545	ENOG4107QM2	Aldo Keto reductase
HC353_RS09550	ENOG4105C12	Phosphoribosylglycinamide synthetase
HC353_RS09555	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HC353_RS09560	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HC353_RS09565	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HC353_RS09570	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HC353_RS09575	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HC353_RS09580	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
HC353_RS09585	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
HC353_RS09590	ENOG4105C8V	SAICAR synthetase
HC353_RS09600	ENOG4105C83	adenylosuccinate lyase
HC353_RS09605	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HC353_RS09610	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HC353_RS09620	ENOG4105C2W	permease
HC353_RS09625	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
HC353_RS09630	ENOG4105DDC	Oxidoreductase domain protein
HC353_RS09640	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HC353_RS09645	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HC353_RS09650	ENOG410769Z	extracellular solute-binding protein family 1
HC353_RS09655	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HC353_RS09660	ENOG4107X35	defense response to bacterium
HC353_RS09665	ENOG4108VXD	carboxy-peptidase
HC353_RS09675	ENOG4105EE0	oxidoreductase
HC353_RS09690	ENOG4105DZ6	Band 7 protein
HC353_RS09710	ENOG4105C5I	Dehydrogenase
HC353_RS09720	ENOG4105CE4	GlcNAc 6-P deacetylase
HC353_RS09730	ENOG4105CHM	Aminotransferase
HC353_RS09755	ENOG4105VRS	hydrolase family 18
HC353_RS09760	ENOG4105F8V	Hydrolase, tatD family
HC353_RS09775	ENOG4105Y36	Binding-protein-dependent transport systems, inner membrane component
HC353_RS09780	ENOG4107QN2	dihydrolipoyl dehydrogenase
HC353_RS09790	ENOG4108HQR	Glycine betaine
HC353_RS09800	ENOG4108JYZ	YitT family
HC353_RS09810	ENOG4105FKQ	transcriptional regulator
HC353_RS09815	ENOG4108MXZ	Esterase
HC353_RS09825	ENOG4108U5N	UPF0316 protein
HC353_RS09840	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
HC353_RS09845	ENOG4105F1A	Pyruvate formate-lyase
HC353_RS09850	ENOG4105C6N	Formate acetyltransferase
HC353_RS09860	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HC353_RS09865	ENOG4105K4P	CoA-binding domain protein
HC353_RS09870	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HC353_RS09880	ENOG4105EUM	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity)
HC353_RS09885	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HC353_RS09890	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HC353_RS09895	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HC353_RS09900	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
HC353_RS09905	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HC353_RS09910	ENOG4105C79	DNA protecting protein DprA
HC353_RS09915	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HC353_RS09920	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HC353_RS09940	ENOG4105VSD	UPF0346 protein
HC353_RS09950	ENOG4105QZP	Uncharacterized protein conserved in bacteria (DUF2140)
HC353_RS09955	ENOG41090WU	lipolytic protein G-D-S-L family
HC353_RS09960	ENOG4108RCR	degv family
HC353_RS09965	ENOG4108UT2	hemolysin iii
HC353_RS09975	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HC353_RS09980	ENOG4105C5H	ABC transporter
HC353_RS09985	ENOG4107SUZ	Sodium/hydrogen exchanger family
HC353_RS10000	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HC353_RS10005	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
HC353_RS10010	ENOG4108JYZ	YitT family
HC353_RS10015	ENOG4108SXZ	UPF0302 protein
HC353_RS10020	ENOG41068YB	TPR repeat-containing protein
HC353_RS10030	ENOG4105K70	DNA-binding protein
HC353_RS10035	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HC353_RS10040	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HC353_RS10045	ENOG4105CAT	Cytidine monophosphate kinase
HC353_RS10050	ENOG41068JE	domain protein
HC353_RS10055	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HC353_RS10075	ENOG4107QSE	Dipeptidase
HC353_RS10080	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HC353_RS10085	ENOG4108SAX	Membrane
HC353_RS10090	ENOG4105FE9	pseudouridine synthase
HC353_RS10095	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HC353_RS10100	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HC353_RS10110	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HC353_RS10115	ENOG4105I3K	Ferric uptake regulator, Fur family
HC353_RS10120	ENOG4105QNR	S1 RNA binding domain protein
HC353_RS10125	ENOG41070VT	
HC353_RS10130	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HC353_RS10135	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HC353_RS10140	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HC353_RS10150	ENOG41065S2	pneumococcal vaccine antigen
HC353_RS10155	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
HC353_RS10210	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
HC353_RS10220	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HC353_RS10225	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HC353_RS10230	ENOG4105DWF	phosphomethylpyrimidine kinase
HC353_RS10240	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
HC353_RS10255	ENOG4107YZX	Universal stress protein
HC353_RS10260	ENOG4105CS2	ec 3.2.1.21
HC353_RS10265	ENOG4105CK1	PTS System
HC353_RS10270	ENOG4108TZY	GntR Family Transcriptional Regulator
HC353_RS10280	ENOG4105FBA	Phospholipase Carboxylesterase
HC353_RS10295	ENOG4105DT3	PTS system, galactitol-specific IIc component
HC353_RS10305	ENOG4105CTS	PTS system mannitol-specific
HC353_RS10310	ENOG4105E98	transcriptional regulator DeoR family
HC353_RS10315	ENOG4105DE4	1-phosphofructokinase
HC353_RS10320	ENOG4108M8W	Monooxygenase
HC353_RS10330	ENOG4105DM4	PTS System
HC353_RS10340	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
HC353_RS10345	ENOG4105H6Q	decarboxylase
HC353_RS10370	ENOG4105E98	transcriptional regulator DeoR family
HC353_RS10385	ENOG4105CI1	PTS System
HC353_RS10390	ENOG4105C87	Aminotransferase class I and II
HC353_RS10415	ENOG4105CK1	PTS System
HC353_RS10515	ENOG4105GR3	Histidine kinase
HC353_RS10520	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HC353_RS10525	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HC353_RS10530	ENOG41067VY	50S ribosomal protein L32
HC353_RS10540	ENOG4107ZGM	malolactic fermentation system
HC353_RS10545	ENOG4105CA9	Pyruvate kinase
HC353_RS10550	ENOG4105CTQ	phosphohexokinase
HC353_RS10555	ENOG4105C0B	DNA polymerase III (alpha subunit)
HC353_RS10565	ENOG4105C6X	Major Facilitator
HC353_RS10570	ENOG4105C7N	Xanthine uracil vitamin C permease
HC353_RS10575	ENOG4108KP7	hydrolase
HC353_RS10580	ENOG4107RF6	penicillin-binding protein
HC353_RS10590	ENOG4105C22	threonyL-tRNA synthetase
HC353_RS10595	ENOG41069HH	4-oxalocrotonate tautomerase
HC353_RS10605	ENOG4105EEM	helicase
HC353_RS10615	ENOG4105CDY	transcriptional regulatory protein
HC353_RS10620	ENOG4105CDE	UPF0348 protein
HC353_RS10625	ENOG4105DXX	methyltransferase
HC353_RS10635	ENOG4108WF2	Metal Dependent Phosphohydrolase
HC353_RS10640	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HC353_RS10645	ENOG410812S	Rna-binding protein
HC353_RS10650	ENOG4105CQW	ribosome biogenesis GTPase YqeH
HC353_RS10655	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
HC353_RS10660	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HC353_RS10665	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HC353_RS10670	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HC353_RS10675	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HC353_RS10685	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HC353_RS10690	ENOG4105CHR	reductase
HC353_RS10695	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HC353_RS10705	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HC353_RS10715	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HC353_RS10720	ENOG4107IN1	Protein of unknown function (DUF1797)
HC353_RS10725	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HC353_RS10730	ENOG4105BZF	Glycosyl transferase (Group 1
HC353_RS10735	ENOG4105W2C	Glycosyl transferase
HC353_RS10740	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HC353_RS10745	ENOG4105KRI	phosphocarrier protein (HPr
HC353_RS10750	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HC353_RS10765	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HC353_RS10775	ENOG4105C02	permease
HC353_RS10785	ENOG4105EVI	UPF0374 protein
HC353_RS10795	ENOG410902V	Modulates RecA activity (By similarity)
HC353_RS10800	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HC353_RS10805	ENOG4108M1A	Chitin-binding protein
HC353_RS10810	ENOG4105CYP	glycoside hydrolase, family
HC353_RS10815	ENOG4105KAV	tspo and mbr like protein
HC353_RS10820	ENOG4108KGH	TRANSCRIPTIONal
HC353_RS10825	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HC353_RS10855	ENOG4105VEQ	Cold shock protein
HC353_RS10860	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HC353_RS10865	ENOG4105WH5	Teichoic acid glycosylation protein
HC353_RS10870	ENOG4105PGM	cation diffusion facilitator family transporter
HC353_RS10895	ENOG4105ZMJ	n-acetylmuramoyl-l-alanine amidase
HC353_RS10905	ENOG4105ENE	Histidine kinase
HC353_RS10915	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HC353_RS10945	ENOG4105KPE	licD family
HC353_RS10955	ENOG4105K64	Glycosyl transferase, family 2
HC353_RS10970	ENOG4105KPE	licD family
HC353_RS10975	ENOG4105K64	Glycosyl transferase, family 2
HC353_RS10990	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HC353_RS11015	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
HC353_RS11020	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HC353_RS11025	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HC353_RS11030	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HC353_RS11035	ENOG4108SHN	Glycosyl transferase, family 2
HC353_RS11050	ENOG4105ESV	Glycosyl transferase, family 4
HC353_RS11055	ENOG4107U9T	Pfam:Ribonuclease_BN
HC353_RS11065	ENOG4105NQC	Flavodoxin
HC353_RS11075	ENOG4105C88	aminopeptidase
HC353_RS11115	ENOG4105CK1	PTS System
HC353_RS11120	ENOG4105VCP	PTS System
HC353_RS11125	ENOG4105VZJ	PTS System
HC353_RS11130	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HC353_RS11135	ENOG4105FDU	atp-dependent rna helicase
HC353_RS11140	ENOG4105EE0	oxidoreductase
HC353_RS11160	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HC353_RS11165	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HC353_RS11170	ENOG4105MMF	Cell division protein DIVIVA
HC353_RS11175	ENOG4105DBK	s4 domain protein
HC353_RS11185	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
HC353_RS11190	ENOG4105DFA	alanine racemase domain protein
HC353_RS11225	ENOG4105CJN	penicillin-binding protein
HC353_RS11260	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HC353_RS11265	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
HC353_RS11270	ENOG4105DX0	Hemolysin A
HC353_RS11280	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HC353_RS11285	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HC353_RS11290	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HC353_RS11295	ENOG4105M7K	Involved in the transcription termination process (By similarity)
HC353_RS11300	ENOG4108ZSR	alkaline shock protein
HC353_RS11305	ENOG4105DC7	peptidase M24
HC353_RS11310	ENOG4107BMA	Transglycosylase associated protein
HC353_RS11320	ENOG4105F3R	pts system mannose fructose sorbose family iid
HC353_RS11325	ENOG4105ETZ	PTS System
HC353_RS11335	ENOG4105DAS	pts system
HC353_RS11340	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HC353_RS11345	ENOG4105K46	50S ribosomal protein l27
HC353_RS11355	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HC353_RS11365	ENOG4105CHH	sulfate transporter
HC353_RS11370	ENOG4105KA3	membrAne
HC353_RS11395	ENOG4105DF9	Lipoate-protein, ligase
HC353_RS11400	ENOG4108RQ5	Beta-lactamase domain-containing protein
HC353_RS11410	ENOG4105CN9	Peptidase m42 family protein
HC353_RS11415	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
HC353_RS11420	ENOG4105X96	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity)
HC353_RS11425	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HC353_RS11430	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
HC353_RS11445	ENOG4105C19	ABC transporter
HC353_RS11450	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HC353_RS11455	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HC353_RS11470	ENOG41063V3	Involved in initiation control of chromosome replication (By similarity)
HC353_RS11475	ENOG4105MA4	psp1 domain protein
HC353_RS11480	ENOG4105FA2	dna polymerase iii
HC353_RS11485	ENOG4105X0R	protein from nitrogen regulatory protein P-II
HC353_RS11490	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HC353_RS11495	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HC353_RS11500	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HC353_RS11505	ENOG4105C6E	dna polymerase iii
HC353_RS11525	ENOG4105TV1	Transcriptional regulator
HC353_RS11535	ENOG4105CZM	Major Facilitator
HC353_RS11545	ENOG4105E98	transcriptional regulator DeoR family
HC353_RS11550	ENOG4105D2N	Aldolase
HC353_RS11555	ENOG4105DM4	PTS System
HC353_RS11620	ENOG41082DI	50s ribosomal protein l31
HC353_RS11625	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HC353_RS11630	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HC353_RS11640	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HC353_RS11645	ENOG4105C5F	glutamine synthetase
HC353_RS11650	ENOG4105KV4	Transcriptional regulator
HC353_RS11655	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HC353_RS11660	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HC353_RS11665	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HC353_RS11675	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HC353_RS11680	ENOG4108Z0R	Transferase
HC353_RS11690	ENOG4105BZ1	(ABC) transporter
HC353_RS11700	ENOG4106EHS	UPF0356 protein
HC353_RS11710	ENOG4105VEQ	Cold shock protein
HC353_RS11715	ENOG4105W5Q	DNA repair protein (RadC
HC353_RS11720	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HC353_RS11725	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HC353_RS11730	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HC353_RS11735	ENOG4108YWR	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
HC353_RS11740	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HC353_RS11745	ENOG4105C3J	Cysteine desulfurase
HC353_RS11750	ENOG4105DGY	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)
HC353_RS11765	ENOG4105I3N	Conserved Protein
HC353_RS11770	ENOG4105HDK	L-asparaginase
HC353_RS11785	ENOG4105CTZ	aminopeptidase c
HC353_RS11860	ENOG4105C87	Aminotransferase class I and II
HC353_RS11870	ENOG4105CAY	ferredoxin--nadp reductase
HC353_RS11875	ENOG4108W5N	phosphatidylglycerophosphatase a
HC353_RS11890	ENOG4105MMD	transcriptional regulator
HC353_RS11895	ENOG4107R8B	5'-nucleotidase
HC353_RS11905	ENOG4108Z6B	deaminase
HC353_RS11920	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HC353_RS11940	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HC353_RS11945	ENOG4105SFS	phosphoesterase RecJ domain protein
HC353_RS11955	ENOG4105E8R	UPF0173 metal-dependent hydrolase
HC353_RS11970	ENOG4107WD8	ABC transporter, permease
HC353_RS11985	ENOG4105DYB	Isoaspartyl dipeptidase
HC353_RS11990	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HC353_RS11995	ENOG4108SU4	UPF0309 protein
HC353_RS12010	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HC353_RS12025	ENOG4108M1A	Chitin-binding protein
HC353_RS12035	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HC353_RS12040	ENOG4105F3R	pts system mannose fructose sorbose family iid
HC353_RS12045	ENOG4105ETZ	PTS System
HC353_RS12060	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HC353_RS12075	ENOG4105BZ1	(ABC) transporter
HC353_RS12080	ENOG4105BZ1	(ABC) transporter
HC353_RS12090	ENOG4108Z5K	methylglyoxal synthase
HC353_RS12095	ENOG4108IJ9	(ABC) transporter
HC353_RS12100	ENOG4105RNB	
HC353_RS12105	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HC353_RS12110	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
HC353_RS12115	ENOG4105F8V	Hydrolase, tatD family
HC353_RS12120	ENOG4107R7I	amino acid
HC353_RS12135	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HC353_RS12150	ENOG4105D7V	transposase
HC353_RS12155	ENOG4108JQ7	(ABC) transporter
HC353_RS12165	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HC353_RS12170	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HC353_RS12195	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HC353_RS12200	ENOG4105CNU	cell division protein FtsK
HC353_RS12205	ENOG4105CS2	ec 3.2.1.21
HC353_RS12210	ENOG4105EAB	amino acid AbC transporter
HC353_RS12215	ENOG4105CDA	abc transporter atp-binding protein
HC353_RS12220	ENOG4105E5Q	amino acid AbC transporter
HC353_RS12250	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HC353_RS12260	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HC353_RS12265	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HC353_RS12270	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HC353_RS12275	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HC353_RS12280	ENOG4107104	thymidine kinase
HC353_RS12285	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HC353_RS12290	ENOG4105C3F	Signal peptidase i
HC353_RS12315	ENOG4105DMS	mur ligase
HC353_RS12320	ENOG4105F1K	Glutamine amidotransferase
HC353_RS12325	ENOG4107SQ3	mannitol-1-phosphate 5-dehydrogenase
HC353_RS12330	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HC353_RS12335	ENOG4105CTS	PTS system mannitol-specific
HC353_RS12345	ENOG4108M15	ABC transporter
HC353_RS12355	ENOG4105DTZ	bifunctional PTS system fructose-specific transporter subunit IIA HPr protein
HC353_RS12360	ENOG4105ETD	TRANSCRIPTIONal
HC353_RS12370	ENOG4105DG6	mannose-6-phosphate isomerase
HC353_RS12385	ENOG4105BZ1	(ABC) transporter
HC353_RS12405	ENOG4108V3G	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)
HC353_RS12420	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HC353_RS12435	ENOG4107T7U	Sulfatase
HC353_RS12440	ENOG4108JQ1	Dehydrogenase
HC353_RS12445	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
HC353_RS12450	ENOG4107R0P	L-ribulose-5-phosphate 4-epimerase
HC353_RS12460	ENOG4107QNK	)-transporter
HC353_RS12470	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HC353_RS12475	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HC353_RS12485	ENOG4105DRS	transport system, permease
HC353_RS12490	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HC353_RS12510	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
HC353_RS12515	ENOG4105DAP	Nicotinate phosphoribosyltransferase
HC353_RS12555	ENOG4107TXC	Transcriptional regulator
HC353_RS12570	ENOG4105CK1	PTS System
HC353_RS12640	ENOG4105E4C	Lytic transglycosylase catalytic
HC353_RS12840	ENOG4105XB7	anti-repressor protein
HC353_RS12875	ENOG4105D5G	Transposase
HC353_RS12885	ENOG4108XZ3	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity)
HC353_RS12920	ENOG4105C4B	ABC transporter, permease
HC353_RS12925	ENOG41083J0	(ABC) transporter
HC353_RS12930	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
HC353_RS12935	ENOG4105D5G	Transposase
HC353_RS12955	ENOG4107Y70	Heat shock protein
HC353_RS12975	ENOG4105D5G	Transposase
HC353_RS12995	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HC353_RS13090	ENOG4108RTU	Aldolase
HC353_RS13095	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HC353_RS13100	ENOG4105C2X	Arabinose 5-phosphate isomerase
HC353_RS13120	ENOG4105E2A	Dehydrogenase
HC353_RS13135	ENOG4105C4W	S-formylglutathione hydrolase
HC353_RS13145	ENOG4105KVH	Transcriptional regulator
HC353_RS13180	ENOG4108UUM	single-stranded DNA-binding protein
HC353_RS13200	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HC353_RS13390	ENOG4108BUD	transposase
HC353_RS13405	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HC353_RS13415	ENOG4105HUF	DNA protection during starvation protein
HC353_RS13420	ENOG4105IJJ	transcriptional regulator, crp fnr family
HC353_RS13425	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HC353_RS13450	ENOG4105CND	Glycosyl transferase, family 2
HC353_RS13465	ENOG4105C59	p-type ATPase
HC353_RS13490	ENOG4105FDP	GntR family transcriptional regulator
HC353_RS13500	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HC353_RS13510	ENOG4108BUD	transposase
HC353_RS13535	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
HC353_RS13565	ENOG4105DZR	Type I site-specific deoxyribonuclease
HC353_RS13570	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5