locus-tag	class	description
HC353_RS00010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HC353_RS00020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS00025	COG2910	NAD(P)H-binding
HC353_RS00030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HC353_RS00045	COG5002	protein histidine kinase activity
HC353_RS00050	COG0745	RESPONSE REGULATOR receiver
HC353_RS00055	COG1307	EDD domain protein, DegV family
HC353_RS00210	COG3422	double-strand break repair
HC353_RS00330	COG1396	sequence-specific DNA binding
HC353_RS00370	COG4974	Belongs to the 'phage' integrase family
HC353_RS00380	COG3448	diguanylate cyclase activity
HC353_RS00380	COG4175	Glycine betaine
HC353_RS00405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HC353_RS00410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HC353_RS00435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS00435	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS00440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC353_RS00450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS00455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS00455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS00455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS00460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS00475	COG2188	Transcriptional regulator
HC353_RS00480	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC353_RS00500	COG0628	permease
HC353_RS00505	COG1285	pathogenesis
HC353_RS00510	COG0363	glucosamine-6-phosphate deaminase activity
HC353_RS00515	COG0488	(ABC) transporter
HC353_RS00520	COG2814	Major facilitator Superfamily
HC353_RS00530	COG0222	ribosome binding
HC353_RS00535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HC353_RS00540	COG0081	regulation of translation
HC353_RS00545	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HC353_RS00550	COG1760	l-serine dehydratase
HC353_RS00555	COG1760	l-serine dehydratase
HC353_RS00560	COG1304	FMN binding
HC353_RS00570	COG0250	Participates in transcription elongation, termination and antitermination
HC353_RS00580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HC353_RS00595	COG1597	lipid kinase activity
HC353_RS00600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HC353_RS00610	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HC353_RS00620	COG3142	Participates in the control of copper homeostasis
HC353_RS00625	COG2239	Acts as a magnesium transporter
HC353_RS00630	COG0564	pseudouridine synthase activity
HC353_RS00635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HC353_RS00640	COG2357	RelA SpoT domain protein
HC353_RS00645	COG4116	CYTH
HC353_RS00665	COG4862	establishment of competence for transformation
HC353_RS00670	COG1393	Belongs to the ArsC family
HC353_RS00685	COG0419	ATPase involved in DNA repair
HC353_RS00690	COG0420	3'-5' exonuclease activity
HC353_RS00695	COG0204	Acyl-transferase
HC353_RS00700	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HC353_RS00705	COG2827	Endonuclease containing a URI domain
HC353_RS00715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC353_RS00720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HC353_RS00725	COG0124	histidyl-tRNA synthetase
HC353_RS00730	COG0667	Aldo Keto reductase
HC353_RS00735	COG2124	cytochrome p450
HC353_RS00740	COG1490	D-aminoacyl-tRNA deacylase activity
HC353_RS00745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HC353_RS00750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HC353_RS00755	COG2264	protein methyltransferase activity
HC353_RS00765	COG2094	Belongs to the DNA glycosylase MPG family
HC353_RS00770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HC353_RS00785	COG0589	response to stress
HC353_RS00790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HC353_RS00795	COG0827	DNA restriction-modification system
HC353_RS00820	COG4537	Required for transformation and DNA binding
HC353_RS00825	COG1459	type II secretion system
HC353_RS00830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HC353_RS00840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HC353_RS00850	COG4473	ABC transporter
HC353_RS00855	COG1131	(ABC) transporter
HC353_RS00860	COG0537	adenosine 5'-monophosphoramidase activity
HC353_RS00870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC353_RS00875	COG3481	metal-dependent phosphohydrolase, HD sub domain
HC353_RS00880	COG4717	serine-type aminopeptidase activity
HC353_RS00885	COG0420	3'-5' exonuclease activity
HC353_RS00915	COG2211	Major facilitator Superfamily
HC353_RS00920	COG3507	Belongs to the glycosyl hydrolase 43 family
HC353_RS00935	COG1073	alpha beta
HC353_RS00945	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC353_RS00950	COG1653	transport
HC353_RS00960	COG4209	transmembrane transport
HC353_RS00965	COG0395	ABC-type sugar transport system, permease component
HC353_RS00970	COG2207	Transcriptional regulator
HC353_RS00975	COG1609	Transcriptional regulator
HC353_RS00980	COG0246	Mannitol dehydrogenase
HC353_RS00985	COG2721	sulfolactate sulfo-lyase activity
HC353_RS00990	COG1904	glucuronate isomerase
HC353_RS01005	COG1132	(ABC) transporter
HC353_RS01010	COG3679	Belongs to the UPF0342 family
HC353_RS01015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC353_RS01020	COG0564	pseudouridine synthase activity
HC353_RS01025	COG1940	carbohydrate kinase activity
HC353_RS01030	COG0383	alpha-mannosidase activity
HC353_RS01050	COG2207	Transcriptional regulator
HC353_RS01050	COG4753	response regulator
HC353_RS01055	COG2972	Histidine kinase
HC353_RS01070	COG0395	ABC-type sugar transport system, permease component
HC353_RS01075	COG1175	transmembrane transport
HC353_RS01080	COG1187	pseudouridine synthase activity
HC353_RS01085	COG2244	polysaccharide biosynthetic process
HC353_RS01095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HC353_RS01110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS01125	COG3711	transcriptional antiterminator
HC353_RS01125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS01145	COG0495	leucyl-tRNA aminoacylation
HC353_RS01150	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC353_RS01150	COG1388	LysM domain
HC353_RS01155	COG0671	phosphoesterase, PA-phosphatase related
HC353_RS01160	COG1242	4 iron, 4 sulfur cluster binding
HC353_RS01165	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HC353_RS01170	COG1132	(ABC) transporter
HC353_RS01175	COG1132	(ABC) transporter
HC353_RS01190	COG0477	Major facilitator Superfamily
HC353_RS01195	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HC353_RS01345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HC353_RS01350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC353_RS01355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HC353_RS01370	COG0037	tRNA processing
HC353_RS01375	COG1098	S1 RNA binding domain
HC353_RS01385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HC353_RS01390	COG2244	polysaccharide biosynthetic process
HC353_RS01395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HC353_RS01400	COG0193	aminoacyl-tRNA hydrolase activity
HC353_RS01405	COG0039	L-malate dehydrogenase activity
HC353_RS01415	COG0217	transcriptional regulatory protein
HC353_RS01440	COG1792	Involved in formation and maintenance of cell shape
HC353_RS01450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HC353_RS01455	COG1162	GTPase activity
HC353_RS01460	COG0515	serine threonine protein kinase
HC353_RS01460	COG2815	serine threonine protein kinase
HC353_RS01465	COG0631	protein serine/threonine phosphatase activity
HC353_RS01470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC353_RS01470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HC353_RS01475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HC353_RS01480	COG0242	peptide deformylase activity
HC353_RS01485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HC353_RS01490	COG1758	RNA polymerase activity
HC353_RS01495	COG0194	GDP metabolic process
HC353_RS01505	COG1561	YicC-like family, N-terminal region
HC353_RS01530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC353_RS01535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HC353_RS01540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC353_RS01545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC353_RS01550	COG1121	(ABC) transporter
HC353_RS01555	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC353_RS01555	COG3443	Belongs to the bacterial solute-binding protein 9 family
HC353_RS01560	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HC353_RS01565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HC353_RS01565	COG0392	lysyltransferase activity
HC353_RS01570	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HC353_RS01575	COG1418	mRNA catabolic process
HC353_RS01580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HC353_RS01585	COG1058	Belongs to the CinA family
HC353_RS01585	COG1546	Belongs to the CinA family
HC353_RS01590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC353_RS01595	COG1426	Protein conserved in bacteria
HC353_RS01600	COG0612	Peptidase, M16
HC353_RS01605	COG0612	Peptidase, M16
HC353_RS01610	COG1970	mechanosensitive ion channel activity
HC353_RS01615	COG2153	protein acetylation
HC353_RS01620	COG4466	Protein conserved in bacteria
HC353_RS01630	COG3688	RNA-binding protein containing a PIN domain
HC353_RS01635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC353_RS01640	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HC353_RS01645	COG0215	cysteine-tRNA ligase activity
HC353_RS01650	COG1045	serine acetyltransferase
HC353_RS01655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HC353_RS01660	COG4956	integral membrane protein (PIN domain superfamily)
HC353_RS01670	COG0756	dUTP diphosphatase activity
HC353_RS01675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HC353_RS01680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HC353_RS01695	COG2814	Major facilitator Superfamily
HC353_RS01715	COG0778	Nitroreductase
HC353_RS01730	COG1388	LysM domain
HC353_RS01730	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC353_RS01740	COG3711	transcriptional antiterminator
HC353_RS01745	COG1263	PTS System
HC353_RS01745	COG2190	(PTS) system
HC353_RS01745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS01750	COG0702	epimerase
HC353_RS01765	COG3708	Transcriptional regulator
HC353_RS01765	COG2207	Transcriptional regulator
HC353_RS01775	COG1070	Carbohydrate kinase
HC353_RS01780	COG0395	ABC-type sugar transport system, permease component
HC353_RS01795	COG3507	Belongs to the glycosyl hydrolase 43 family
HC353_RS01800	COG2115	Belongs to the xylose isomerase family
HC353_RS01805	COG1940	carbohydrate kinase activity
HC353_RS01845	COG1674	ftsk spoiiie
HC353_RS01850	COG4499	WXG100 protein secretion system (Wss), protein YukC
HC353_RS01870	COG4842	Belongs to the WXG100 family
HC353_RS01885	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HC353_RS01895	COG0604	alcohol dehydrogenase
HC353_RS01900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HC353_RS01905	COG0842	Transport permease protein
HC353_RS01910	COG1131	(ABC) transporter
HC353_RS01915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HC353_RS01920	COG2205	protein histidine kinase activity
HC353_RS01945	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HC353_RS01950	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HC353_RS01955	COG0783	Belongs to the Dps family
HC353_RS01960	COG1070	Carbohydrate kinase
HC353_RS01965	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HC353_RS01970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HC353_RS01980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HC353_RS01985	COG0085	RNA polymerase activity
HC353_RS01995	COG4120	Belongs to the binding-protein-dependent transport system permease family
HC353_RS02005	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HC353_RS02005	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HC353_RS02025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC353_RS02040	COG0542	response to heat
HC353_RS02045	COG4463	regulation of RNA biosynthetic process
HC353_RS02120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HC353_RS02125	COG0516	GMP reductase activity
HC353_RS02125	COG0517	IMP dehydrogenase activity
HC353_RS02135	COG0012	GTP binding
HC353_RS02140	COG4481	Protein conserved in bacteria
HC353_RS02145	COG1475	DNA binding
HC353_RS02150	COG1192	Involved in chromosome partitioning
HC353_RS02155	COG0357	Ribosomal RNA small subunit methyltransferase G
HC353_RS02160	COG0445	tRNA wobble uridine modification
HC353_RS02165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HC353_RS02175	COG1847	R3H domain protein
HC353_RS02180	COG0706	membrane insertase activity
HC353_RS02185	COG0594	ribonuclease P activity
HC353_RS02190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HC353_RS02195	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HC353_RS02200	COG0592	DNA-directed DNA polymerase activity
HC353_RS02205	COG2501	S4 domain
HC353_RS02210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HC353_RS02215	COG0187	DNA topoisomerase II activity
HC353_RS02225	COG0360	Binds together with S18 to 16S ribosomal RNA
HC353_RS02230	COG0629	single-stranded DNA binding
HC353_RS02235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HC353_RS02245	COG0359	binds to the 23S rRNA
HC353_RS02250	COG0305	Participates in initiation and elongation during chromosome replication
HC353_RS02260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HC353_RS02270	COG0488	(ABC) transporter
HC353_RS02280	COG0028	Belongs to the TPP enzyme family
HC353_RS02330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HC353_RS02330	COG0519	Catalyzes the synthesis of GMP from XMP
HC353_RS02335	COG1072	(Pantothenic acid kinase))
HC353_RS02340	COG2813	Specifically methylates the guanine in position
HC353_RS02345	COG1609	Transcriptional regulator
HC353_RS02350	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HC353_RS02355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HC353_RS02360	COG0295	cytidine deaminase activity
HC353_RS02365	COG1744	ABC transporter substrate-binding protein PnrA-like
HC353_RS02385	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HC353_RS02405	COG0588	phosphoglycerate mutase activity
HC353_RS02415	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HC353_RS02420	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HC353_RS02425	COG0049	tRNA binding
HC353_RS02430	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HC353_RS02435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HC353_RS02440	COG0051	transcription antitermination factor activity, RNA binding
HC353_RS02445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HC353_RS02450	COG0088	Forms part of the polypeptide exit tunnel
HC353_RS02455	COG0089	rRNA binding
HC353_RS02460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HC353_RS02470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HC353_RS02475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HC353_RS02480	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HC353_RS02485	COG0255	Belongs to the universal ribosomal protein uL29 family
HC353_RS02490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HC353_RS02495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HC353_RS02500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HC353_RS02505	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HC353_RS02510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC353_RS02515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HC353_RS02520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HC353_RS02525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HC353_RS02530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HC353_RS02535	COG1841	ribosomal large subunit assembly
HC353_RS02540	COG0200	Binds to the 23S rRNA
HC353_RS02545	COG0201	protein transport
HC353_RS02550	COG0563	adenylate kinase activity
HC353_RS02555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HC353_RS02560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HC353_RS02565	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HC353_RS02570	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HC353_RS02575	COG0202	RNA polymerase activity
HC353_RS02580	COG0203	ribosomal protein L17
HC353_RS02585	COG1122	ATPase activity
HC353_RS02590	COG1122	ATPase activity
HC353_RS02600	COG0101	tRNA pseudouridine synthase activity
HC353_RS02610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HC353_RS02620	COG1461	Dihydroxyacetone kinase
HC353_RS02625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HC353_RS02630	COG0416	fatty acid biosynthetic process
HC353_RS02635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC353_RS02645	COG4608	Belongs to the ABC transporter superfamily
HC353_RS02650	COG0601	transmembrane transport
HC353_RS02655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC353_RS02675	COG0571	ribonuclease III activity
HC353_RS02680	COG1196	nuclear chromosome segregation
HC353_RS02685	COG0561	phosphatase activity
HC353_RS02690	COG0552	protein localization to endoplasmic reticulum
HC353_RS02695	COG2918	glutathione biosynthetic process
HC353_RS02695	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC353_RS02705	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC353_RS02710	COG4605	iron ion homeostasis
HC353_RS02715	COG4604	ABC transporter, ATP-binding protein
HC353_RS02745	COG1349	DNA-binding transcription factor activity
HC353_RS02750	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC353_RS02760	COG2723	6-phospho-beta-galactosidase activity
HC353_RS02780	COG3684	Belongs to the aldolase LacD family
HC353_RS02810	COG1380	Effector of murein hydrolase LrgA
HC353_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
HC353_RS02840	COG1268	BioY protein
HC353_RS02845	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HC353_RS02860	COG0561	phosphatase activity
HC353_RS02865	COG1692	metallophosphoesterase
HC353_RS02875	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HC353_RS02880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HC353_RS02885	COG0424	maF-like protein
HC353_RS02890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS02890	COG1263	PTS System
HC353_RS02895	COG2188	Transcriptional regulator
HC353_RS02905	COG0632	four-way junction helicase activity
HC353_RS02910	COG2255	four-way junction helicase activity
HC353_RS02920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HC353_RS02940	COG1114	Component of the transport system for branched-chain amino acids
HC353_RS02950	COG1113	amino acid transport
HC353_RS02955	COG1126	abc transporter atp-binding protein
HC353_RS02960	COG0765	amino acid transport
HC353_RS02970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HC353_RS02975	COG0110	maltose O-acetyltransferase activity
HC353_RS02980	COG1827	regulation of RNA biosynthetic process
HC353_RS02995	COG0242	peptide deformylase activity
HC353_RS03000	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HC353_RS03005	COG1185	polyribonucleotide nucleotidyltransferase activity
HC353_RS03015	COG3158	transport of potassium into the cell
HC353_RS03020	COG1253	flavin adenine dinucleotide binding
HC353_RS03025	COG0534	Mate efflux family protein
HC353_RS03035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HC353_RS03040	COG1187	pseudouridine synthase activity
HC353_RS03050	COG0572	uridine kinase
HC353_RS03070	COG1671	Belongs to the UPF0178 family
HC353_RS03080	COG1181	Belongs to the D-alanine--D-alanine ligase family
HC353_RS03085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC353_RS03095	COG0736	holo-[acyl-carrier-protein] synthase activity
HC353_RS03100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HC353_RS03105	COG2337	Toxic component of a toxin-antitoxin (TA) module
HC353_RS03110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HC353_RS03115	COG0604	alcohol dehydrogenase
HC353_RS03115	COG3321	synthase
HC353_RS03125	COG0531	amino acid
HC353_RS03130	COG1174	glycine betaine transport
HC353_RS03150	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HC353_RS03165	COG0343	queuine tRNA-ribosyltransferase activity
HC353_RS03170	COG1862	Preprotein translocase
HC353_RS03175	COG1454	alcohol dehydrogenase
HC353_RS03175	COG1012	belongs to the aldehyde dehydrogenase family
HC353_RS03180	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HC353_RS03200	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HC353_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
HC353_RS03210	COG1304	FMN binding
HC353_RS03225	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HC353_RS03230	COG1428	Deoxynucleoside kinase
HC353_RS03245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HC353_RS03250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HC353_RS03255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HC353_RS03260	COG3711	transcriptional antiterminator
HC353_RS03265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS03265	COG2190	(PTS) system
HC353_RS03265	COG1263	PTS System
HC353_RS03275	COG0641	radical SAM
HC353_RS03320	COG0824	Thioesterase
HC353_RS03325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HC353_RS03345	COG1363	Peptidase, m42
HC353_RS03350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC353_RS03355	COG0589	response to stress
HC353_RS03360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC353_RS03365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HC353_RS03370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HC353_RS03380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS03380	COG3711	transcriptional antiterminator
HC353_RS03385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS03390	COG3775	system Galactitol-specific IIC component
HC353_RS03395	COG3414	Phosphotransferase system galactitol-specific IIB component
HC353_RS03495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HC353_RS03505	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HC353_RS03515	COG3328	transposase activity
HC353_RS03520	COG2261	transglycosylase associated protein
HC353_RS03525	COG1764	response to oxidative stress
HC353_RS03550	COG1940	carbohydrate kinase activity
HC353_RS03570	COG0366	Alpha amylase catalytic
HC353_RS03600	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HC353_RS03640	COG0101	tRNA pseudouridine synthase activity
HC353_RS03650	COG0667	Aldo Keto reductase
HC353_RS03655	COG2186	Transcriptional regulator
HC353_RS03660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS03665	COG2723	6-phospho-beta-galactosidase activity
HC353_RS03675	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC353_RS03680	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS03695	COG1063	alcohol dehydrogenase
HC353_RS03705	COG4716	Myosin-crossreactive antigen
HC353_RS03740	COG1113	amino acid transport
HC353_RS03765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC353_RS03775	COG3052	prosthetic group binding
HC353_RS03845	COG1051	belongs to the nudix hydrolase family
HC353_RS03850	COG1846	Transcriptional regulator
HC353_RS03875	COG2252	PERMEase
HC353_RS03880	COG0366	Alpha amylase catalytic
HC353_RS03890	COG1902	pentaerythritol trinitrate reductase activity
HC353_RS03900	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC353_RS03910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HC353_RS03915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HC353_RS03920	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HC353_RS03925	COG1193	negative regulation of DNA recombination
HC353_RS03930	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HC353_RS03940	COG1937	Protein conserved in bacteria
HC353_RS03945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC353_RS03950	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC353_RS03955	COG3973	AAA domain
HC353_RS03980	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HC353_RS03985	COG2376	Dihydroxyacetone kinase
HC353_RS03990	COG1461	Dihydroxyacetone kinase
HC353_RS04020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC353_RS04025	COG3559	Exporter of polyketide antibiotics
HC353_RS04030	COG1131	(ABC) transporter
HC353_RS04035	COG1309	transcriptional regulator
HC353_RS04055	COG0531	amino acid
HC353_RS04090	COG1609	Transcriptional regulator
HC353_RS04100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC353_RS04110	COG2190	(PTS) system
HC353_RS04110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS04110	COG1263	PTS System
HC353_RS04135	COG3479	Phenolic acid decarboxylase
HC353_RS04140	COG1695	Transcriptional regulator
HC353_RS04150	COG2814	Major facilitator Superfamily
HC353_RS04170	COG0163	prenyltransferase activity
HC353_RS04175	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HC353_RS04185	COG0577	efflux transmembrane transporter activity
HC353_RS04185	COG1136	(ABC) transporter
HC353_RS04185	COG1136	(ABC) transporter
HC353_RS04185	COG0577	efflux transmembrane transporter activity
HC353_RS04195	COG5002	protein histidine kinase activity
HC353_RS04205	COG1811	Na channel or pump
HC353_RS04240	COG1136	(ABC) transporter
HC353_RS04255	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC353_RS04255	COG3942	CHAP domain
HC353_RS04260	COG1263	PTS System
HC353_RS04260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS04260	COG2190	(PTS) system
HC353_RS04265	COG1869	D-ribose catabolic process
HC353_RS04275	COG1609	Transcriptional regulator
HC353_RS04295	COG0366	Alpha amylase catalytic
HC353_RS04300	COG0628	permease
HC353_RS04305	COG3443	Belongs to the bacterial solute-binding protein 9 family
HC353_RS04305	COG0803	Belongs to the bacterial solute-binding protein 9 family
HC353_RS04330	COG1428	Deoxynucleoside kinase
HC353_RS04340	COG0210	DNA helicase
HC353_RS04345	COG1393	Belongs to the ArsC family
HC353_RS04350	COG1393	Belongs to the ArsC family
HC353_RS04370	COG0386	Belongs to the glutathione peroxidase family
HC353_RS04375	COG1854	S-ribosylhomocysteine lyase activity
HC353_RS04380	COG0626	cystathionine gamma-synthase activity
HC353_RS04385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC353_RS04390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HC353_RS04395	COG0484	heat shock protein binding
HC353_RS04405	COG0019	diaminopimelate decarboxylase activity
HC353_RS04410	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HC353_RS04420	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HC353_RS04425	COG2171	N-acyltransferase activity
HC353_RS04430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HC353_RS04435	COG0527	aspartate kinase activity
HC353_RS04440	COG1473	amidohydrolase
HC353_RS04445	COG0436	Aminotransferase
HC353_RS04450	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC353_RS04465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HC353_RS04470	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HC353_RS04485	COG2207	Transcriptional regulator
HC353_RS04490	COG2249	NAD(P)H dehydrogenase (quinone) activity
HC353_RS04505	COG1113	amino acid transport
HC353_RS04510	COG1121	(ABC) transporter
HC353_RS04515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HC353_RS04530	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HC353_RS04535	COG2823	Periplasmic or secreted lipoprotein
HC353_RS04535	COG1652	LysM domain
HC353_RS04545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HC353_RS04550	COG0477	Major facilitator Superfamily
HC353_RS04565	COG1438	arginine binding
HC353_RS04580	COG1764	response to oxidative stress
HC353_RS04590	COG1335	isochorismatase
HC353_RS04615	COG3546	catalase activity
HC353_RS04625	COG1175	transmembrane transport
HC353_RS04630	COG0395	ABC-type sugar transport system, permease component
HC353_RS04640	COG0671	phosphoesterase, PA-phosphatase related
HC353_RS04670	COG0745	RESPONSE REGULATOR receiver
HC353_RS04675	COG2205	protein histidine kinase activity
HC353_RS04680	COG4975	Glucose uptake
HC353_RS04685	COG0531	amino acid
HC353_RS04690	COG3853	Toxic anion resistance protein (TelA)
HC353_RS04710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HC353_RS04715	COG1335	isochorismatase
HC353_RS04730	COG3590	peptidase
HC353_RS04740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HC353_RS04745	COG1104	cysteine desulfurase activity
HC353_RS04795	COG0482	sulfurtransferase activity
HC353_RS04805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HC353_RS04810	COG2814	Major facilitator Superfamily
HC353_RS04835	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HC353_RS04840	COG2855	membrane
HC353_RS04850	COG0583	DNA-binding transcription factor activity
HC353_RS04855	COG0772	Belongs to the SEDS family
HC353_RS04860	COG1393	Belongs to the ArsC family
HC353_RS04865	COG0509	glycine decarboxylation via glycine cleavage system
HC353_RS04870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC353_RS04875	COG2011	ABC-type metal ion transport system permease component
HC353_RS04880	COG1464	Belongs to the NlpA lipoprotein family
HC353_RS04890	COG0719	Fe-S assembly protein
HC353_RS04895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HC353_RS04905	COG0719	Fe-S assembly protein
HC353_RS04975	COG1136	(ABC) transporter
HC353_RS04975	COG0577	efflux transmembrane transporter activity
HC353_RS05000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC353_RS05020	COG1597	lipid kinase activity
HC353_RS05075	COG2814	Major facilitator Superfamily
HC353_RS05080	COG1733	regulation of RNA biosynthetic process
HC353_RS05090	COG3764	Sortase (surface protein transpeptidase)
HC353_RS05095	COG3711	transcriptional antiterminator
HC353_RS05100	COG2190	(PTS) system
HC353_RS05100	COG1263	PTS System
HC353_RS05100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS05105	COG2723	6-phospho-beta-galactosidase activity
HC353_RS05110	COG2188	Transcriptional regulator
HC353_RS05120	COG1611	Belongs to the LOG family
HC353_RS05130	COG1428	Deoxynucleoside kinase
HC353_RS05140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS05145	COG1472	Belongs to the glycosyl hydrolase 3 family
HC353_RS05155	COG2723	6-phospho-beta-galactosidase activity
HC353_RS05170	COG1368	sulfuric ester hydrolase activity
HC353_RS05180	COG0105	UTP biosynthetic process
HC353_RS05185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC353_RS05195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HC353_RS05200	COG2011	ABC-type metal ion transport system permease component
HC353_RS05205	COG1464	Belongs to the NlpA lipoprotein family
HC353_RS05210	COG1473	amidohydrolase
HC353_RS05225	COG1113	amino acid transport
HC353_RS05235	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC353_RS05240	COG1929	Belongs to the glycerate kinase type-1 family
HC353_RS05245	COG0488	(ABC) transporter
HC353_RS05260	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HC353_RS05265	COG1263	PTS System
HC353_RS05265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS05270	COG1780	Probably involved in ribonucleotide reductase function
HC353_RS05280	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HC353_RS05285	COG1131	(ABC) transporter
HC353_RS05305	COG1136	(ABC) transporter
HC353_RS05320	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HC353_RS05335	COG0346	lactoylglutathione lyase activity
HC353_RS05360	COG0561	phosphatase activity
HC353_RS05365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HC353_RS05370	COG0280	phosphate acetyltransferase
HC353_RS05375	COG0802	atpase or kinase
HC353_RS05380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HC353_RS05390	COG0708	Exodeoxyribonuclease III
HC353_RS05400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HC353_RS05425	COG1053	succinate dehydrogenase
HC353_RS05430	COG1028	Short-chain dehydrogenase reductase Sdr
HC353_RS05430	COG0604	alcohol dehydrogenase
HC353_RS05430	COG3321	synthase
HC353_RS05435	COG0702	epimerase
HC353_RS05440	COG4684	Psort location CytoplasmicMembrane, score
HC353_RS05445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC353_RS05450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HC353_RS05455	COG0604	alcohol dehydrogenase
HC353_RS05465	COG3842	ATPase activity
HC353_RS05470	COG1176	ABC-type spermidine putrescine transport system, permease component I
HC353_RS05475	COG1177	transmembrane transport
HC353_RS05480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HC353_RS05500	COG1131	(ABC) transporter
HC353_RS05515	COG3279	Response regulator of the LytR AlgR family
HC353_RS05525	COG1132	(ABC) transporter
HC353_RS05530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC353_RS05540	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC353_RS05545	COG0488	(ABC) transporter
HC353_RS05550	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HC353_RS05555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HC353_RS05560	COG0701	Predicted permease
HC353_RS05565	COG3689	TIGRFAM TIGR03943 family protein
HC353_RS05595	COG4472	Bacterial protein of unknown function (DUF965)
HC353_RS05600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HC353_RS05605	COG3906	Belongs to the UPF0473 family
HC353_RS05625	COG0281	malic enzyme
HC353_RS05635	COG1304	FMN binding
HC353_RS05665	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC353_RS05675	COG1136	(ABC) transporter
HC353_RS05695	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC353_RS05710	COG1193	negative regulation of DNA recombination
HC353_RS05715	COG3118	belongs to the thioredoxin family
HC353_RS05720	COG0322	excinuclease ABC activity
HC353_RS05725	COG4152	abc transporter atp-binding protein
HC353_RS05735	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HC353_RS05740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HC353_RS05750	COG1269	ATP hydrolysis coupled proton transport
HC353_RS05755	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC353_RS05760	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HC353_RS05765	COG1527	subunit (C
HC353_RS05770	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HC353_RS05775	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HC353_RS05780	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HC353_RS05785	COG1394	ATPase activity, coupled to movement of substances
HC353_RS05790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC353_RS05795	COG0346	lactoylglutathione lyase activity
HC353_RS05800	COG0494	nUDIX hydrolase
HC353_RS05805	COG0561	phosphatase activity
HC353_RS05810	COG1078	dGTPase activity
HC353_RS05815	COG0095	Lipoate-protein ligase
HC353_RS05830	COG1595	DNA-templated transcription, initiation
HC353_RS05865	COG1131	(ABC) transporter
HC353_RS05875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HC353_RS05880	COG2390	Transcriptional regulator
HC353_RS05890	COG0126	phosphoglycerate kinase activity
HC353_RS05895	COG0149	triose-phosphate isomerase activity
HC353_RS05935	COG2388	GCN5-related N-acetyl-transferase
HC353_RS05940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HC353_RS05950	COG0557	exoribonuclease II activity
HC353_RS05955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HC353_RS05960	COG0356	it plays a direct role in the translocation of protons across the membrane
HC353_RS05965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC353_RS05970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HC353_RS05975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HC353_RS05980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HC353_RS05985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HC353_RS05990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HC353_RS05995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HC353_RS06005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC353_RS06025	COG1940	carbohydrate kinase activity
HC353_RS06050	COG2188	Transcriptional regulator
HC353_RS06055	COG1739	Uncharacterized protein family UPF0029
HC353_RS06065	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS06070	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HC353_RS06085	COG0653	protein targeting
HC353_RS06095	COG2884	Cell division ATP-binding protein ftsE
HC353_RS06100	COG2177	Part of the ABC transporter FtsEX involved in
HC353_RS06105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC353_RS06110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC353_RS06115	COG0573	inorganic phosphate transmembrane transporter activity
HC353_RS06120	COG0581	inorganic phosphate transmembrane transporter activity
HC353_RS06125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC353_RS06130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HC353_RS06135	COG0704	Plays a role in the regulation of phosphate uptake
HC353_RS06160	COG1950	PFAM Membrane protein of
HC353_RS06165	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HC353_RS06170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC353_RS06175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC353_RS06180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HC353_RS06190	COG4980	gas vesicle protein
HC353_RS06200	COG1609	Transcriptional regulator
HC353_RS06245	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HC353_RS06255	COG1914	H( )-stimulated, divalent metal cation uptake system
HC353_RS06260	COG3763	UPF0154 protein
HC353_RS06265	COG1132	(ABC) transporter
HC353_RS06270	COG1132	(ABC) transporter
HC353_RS06275	COG3711	transcriptional antiterminator
HC353_RS06295	COG1737	Transcriptional regulator
HC353_RS06300	COG1486	melibiose metabolic process
HC353_RS06305	COG2723	6-phospho-beta-galactosidase activity
HC353_RS06310	COG0492	ferredoxin-NADP+ reductase activity
HC353_RS06315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC353_RS06320	COG0640	Transcriptional regulator
HC353_RS06325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HC353_RS06330	COG0735	belongs to the Fur family
HC353_RS06335	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HC353_RS06340	COG1610	YqeY-like protein
HC353_RS06345	COG1114	Component of the transport system for branched-chain amino acids
HC353_RS06350	COG1702	phosphate starvation-inducible protein PhoH
HC353_RS06360	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HC353_RS06365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HC353_RS06370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HC353_RS06375	COG1381	Involved in DNA repair and RecF pathway recombination
HC353_RS06380	COG0752	glycyl-tRNA synthetase alpha subunit
HC353_RS06385	COG0751	glycine-tRNA ligase activity
HC353_RS06395	COG1316	TRANSCRIPTIONal
HC353_RS06400	COG3944	biosynthesis protein
HC353_RS06405	COG0489	protein tyrosine kinase activity
HC353_RS06410	COG4464	protein tyrosine phosphatase activity
HC353_RS06420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC353_RS06425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC353_RS06435	COG1086	Polysaccharide biosynthesis protein
HC353_RS06460	COG1216	Glycosyl transferase, family 2
HC353_RS06480	COG1105	Belongs to the carbohydrate kinase PfkB family
HC353_RS06485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS06485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS06485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS06490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC353_RS06490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS06490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS06495	COG3684	Belongs to the aldolase LacD family
HC353_RS06500	COG0706	membrane insertase activity
HC353_RS06505	COG1254	Belongs to the acylphosphatase family
HC353_RS06510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HC353_RS06525	COG0038	chloride channel
HC353_RS06535	COG1686	Belongs to the peptidase S11 family
HC353_RS06555	COG1278	Cold shock
HC353_RS06560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HC353_RS06560	COG1199	ATP-dependent helicase activity
HC353_RS06570	COG0436	Aminotransferase
HC353_RS06575	COG0017	Asparaginyl-tRNA synthetase
HC353_RS06600	COG2217	Heavy metal translocating P-type atpase
HC353_RS06605	COG0531	amino acid
HC353_RS06615	COG3682	Transcriptional regulator
HC353_RS06620	COG2608	mercury ion transmembrane transporter activity
HC353_RS06625	COG2217	Heavy metal translocating P-type atpase
HC353_RS06630	COG2217	Heavy metal translocating P-type atpase
HC353_RS06635	COG1305	Transglutaminase-like
HC353_RS06650	COG0714	Associated with various cellular activities
HC353_RS06675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HC353_RS06680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC353_RS06690	COG5002	protein histidine kinase activity
HC353_RS06695	COG0745	RESPONSE REGULATOR receiver
HC353_RS06705	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HC353_RS06710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HC353_RS06715	COG0519	Catalyzes the synthesis of GMP from XMP
HC353_RS06720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HC353_RS06725	COG0431	NADPH-dependent FMN reductase
HC353_RS06730	COG3620	sequence-specific DNA binding
HC353_RS06740	COG1131	(ABC) transporter
HC353_RS06750	COG0228	four-way junction DNA binding
HC353_RS06755	COG1837	Belongs to the UPF0109 family
HC353_RS06765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HC353_RS06770	COG0336	Belongs to the RNA methyltransferase TrmD family
HC353_RS06775	COG0335	large ribosomal subunit rRNA binding
HC353_RS06785	COG0028	Belongs to the TPP enzyme family
HC353_RS06790	COG3527	Alpha-acetolactate decarboxylase
HC353_RS06795	COG1956	GAF domain-containing protein
HC353_RS06870	COG0745	RESPONSE REGULATOR receiver
HC353_RS06875	COG5002	protein histidine kinase activity
HC353_RS06875	COG3850	Histidine kinase
HC353_RS06890	COG1368	sulfuric ester hydrolase activity
HC353_RS06895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HC353_RS06900	COG0710	3-dehydroquinate dehydratase activity
HC353_RS06905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HC353_RS06910	COG2081	HI0933 family
HC353_RS06915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HC353_RS06920	COG0166	Belongs to the GPI family
HC353_RS06925	COG4974	Belongs to the 'phage' integrase family
HC353_RS06940	COG3620	sequence-specific DNA binding
HC353_RS07000	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HC353_RS07025	COG0584	glycerophosphoryl diester phosphodiesterase
HC353_RS07035	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HC353_RS07055	COG1309	transcriptional regulator
HC353_RS07065	COG0367	asparagine synthase
HC353_RS07070	COG4876	unkown
HC353_RS07075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HC353_RS07090	COG1120	ATPase activity
HC353_RS07095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC353_RS07100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HC353_RS07105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HC353_RS07120	COG1940	carbohydrate kinase activity
HC353_RS07125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HC353_RS07130	COG3189	MarR family transcriptional regulator
HC353_RS07145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HC353_RS07150	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HC353_RS07155	COG1609	Transcriptional regulator
HC353_RS07160	COG1214	PFAM Peptidase M22, glycoprotease
HC353_RS07170	COG0456	acetyltransferase
HC353_RS07175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HC353_RS07180	COG0489	protein tyrosine kinase activity
HC353_RS07190	COG2235	arginine
HC353_RS07205	COG0018	arginyl-trna synthetase
HC353_RS07210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HC353_RS07210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC353_RS07220	COG1438	arginine binding
HC353_RS07225	COG0052	Belongs to the universal ribosomal protein uS2 family
HC353_RS07230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HC353_RS07235	COG0528	UMP kinase activity
HC353_RS07240	COG0233	cytoplasmic translational termination
HC353_RS07245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HC353_RS07250	COG4589	Belongs to the CDS family
HC353_RS07255	COG0750	zinc metalloprotease
HC353_RS07260	COG0442	prolyl-tRNA aminoacylation
HC353_RS07265	COG2176	DNA-directed DNA polymerase activity
HC353_RS07270	COG0779	Required for maturation of 30S ribosomal subunits
HC353_RS07275	COG0195	Participates in both transcription termination and antitermination
HC353_RS07280	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HC353_RS07295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HC353_RS07300	COG1175	transmembrane transport
HC353_RS07305	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HC353_RS07310	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HC353_RS07315	COG0196	riboflavin kinase activity
HC353_RS07345	COG1619	proteins homologs of microcin C7 resistance protein MccF
HC353_RS07355	COG1263	PTS System
HC353_RS07355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS07360	COG1486	melibiose metabolic process
HC353_RS07365	COG1737	Transcriptional regulator
HC353_RS07375	COG0693	protein deglycase activity
HC353_RS07435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HC353_RS07440	COG1420	regulation of RNA biosynthetic process
HC353_RS07445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HC353_RS07450	COG0443	Heat shock 70 kDa protein
HC353_RS07455	COG0484	heat shock protein binding
HC353_RS07470	COG3835	regulator
HC353_RS07475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC353_RS07480	COG2084	Dehydrogenase
HC353_RS07490	COG2851	Citrate transporter
HC353_RS07495	COG4948	Mandelate Racemase Muconate Lactonizing
HC353_RS07500	COG1929	Belongs to the glycerate kinase type-1 family
HC353_RS07505	COG1126	abc transporter atp-binding protein
HC353_RS07510	COG0765	amino acid transport
HC353_RS07515	COG0556	nucleotide-excision repair
HC353_RS07520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC353_RS07530	COG1794	racemase activity, acting on amino acids and derivatives
HC353_RS07535	COG1660	Displays ATPase and GTPase activities
HC353_RS07540	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HC353_RS07545	COG1481	regulation of sporulation
HC353_RS07575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HC353_RS07590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC353_RS07605	COG1714	RDD family
HC353_RS07615	COG0544	peptidyl-prolyl cis-trans isomerase activity
HC353_RS07620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HC353_RS07625	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HC353_RS07645	COG1349	DNA-binding transcription factor activity
HC353_RS07650	COG1105	Belongs to the carbohydrate kinase PfkB family
HC353_RS07655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS07655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS07655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS07660	COG0038	chloride channel
HC353_RS07665	COG0210	DNA helicase
HC353_RS07670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HC353_RS07675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC353_RS07680	COG0154	amidase activity
HC353_RS07685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HC353_RS07690	COG1597	lipid kinase activity
HC353_RS07695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC353_RS07705	COG1132	(ABC) transporter
HC353_RS07715	COG0789	Transcriptional regulator
HC353_RS07715	COG4978	Transcriptional regulator
HC353_RS07720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HC353_RS07725	COG0657	acetylesterase activity
HC353_RS07730	COG1609	Transcriptional regulator
HC353_RS07745	COG3250	beta-galactosidase activity
HC353_RS07750	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HC353_RS07760	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HC353_RS07765	COG0287	Prephenate dehydrogenase
HC353_RS07770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HC353_RS07775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HC353_RS07780	COG0077	Prephenate dehydratase
HC353_RS07785	COG2972	Histidine kinase
HC353_RS07790	COG4753	response regulator
HC353_RS07790	COG2207	Transcriptional regulator
HC353_RS07835	COG0588	phosphoglycerate mutase activity
HC353_RS07870	COG2183	response to ionizing radiation
HC353_RS07875	COG3091	SprT-like family
HC353_RS07880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HC353_RS07885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HC353_RS07900	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC353_RS07900	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HC353_RS07905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HC353_RS07910	COG0237	dephospho-CoA kinase activity
HC353_RS07920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HC353_RS07930	COG1484	DNA-dependent DNA replication
HC353_RS07940	COG2384	SAM-dependent methyltransferase
HC353_RS07945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HC353_RS07950	COG2195	Cleaves the N-terminal amino acid of tripeptides
HC353_RS07955	COG1597	lipid kinase activity
HC353_RS07970	COG0542	response to heat
HC353_RS07990	COG0481	GTPase activity
HC353_RS08010	COG1278	Cold shock
HC353_RS08065	COG0584	glycerophosphoryl diester phosphodiesterase
HC353_RS08070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HC353_RS08095	COG1073	alpha beta
HC353_RS08100	COG2272	Belongs to the type-B carboxylesterase lipase family
HC353_RS08115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC353_RS08120	COG1278	Cold shock
HC353_RS08135	COG1476	TRANSCRIPTIONal
HC353_RS08165	COG0561	phosphatase activity
HC353_RS08170	COG1442	glycosyl transferase family 8
HC353_RS08175	COG1442	glycosyl transferase family 8
HC353_RS08190	COG1028	Short-chain dehydrogenase reductase Sdr
HC353_RS08210	COG2261	transglycosylase associated protein
HC353_RS08230	COG3655	Transcriptional regulator
HC353_RS08245	COG3279	Response regulator of the LytR AlgR family
HC353_RS08280	COG2261	transglycosylase associated protein
HC353_RS08285	COG0004	ammonium transporteR
HC353_RS08290	COG0531	amino acid
HC353_RS08305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HC353_RS08320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HC353_RS08340	COG0768	penicillin binding
HC353_RS08365	COG0450	alkyl hydroperoxide reductase
HC353_RS08380	COG1312	Catalyzes the dehydration of D-mannonate
HC353_RS08395	COG0628	permease
HC353_RS08400	COG1846	Transcriptional regulator
HC353_RS08405	COG1764	response to oxidative stress
HC353_RS08415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC353_RS08420	COG0366	Alpha amylase catalytic
HC353_RS08425	COG2182	Extracellular solute-binding protein
HC353_RS08430	COG1175	transmembrane transport
HC353_RS08435	COG3833	ABC-type maltose transport systems, permease component
HC353_RS08445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HC353_RS08455	COG0167	dihydroorotate dehydrogenase activity
HC353_RS08465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC353_RS08470	COG0765	amino acid transport
HC353_RS08490	COG0194	GDP metabolic process
HC353_RS08495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HC353_RS08545	COG2244	polysaccharide biosynthetic process
HC353_RS08550	COG1307	EDD domain protein, DegV family
HC353_RS08565	COG0366	Alpha amylase catalytic
HC353_RS08570	COG4475	Protein of unknown function (DUF436)
HC353_RS08580	COG0351	phosphomethylpyrimidine kinase
HC353_RS08610	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HC353_RS08615	COG5002	protein histidine kinase activity
HC353_RS08670	COG0673	inositol 2-dehydrogenase activity
HC353_RS08680	COG3711	transcriptional antiterminator
HC353_RS08690	COG3037	sugar-specific permease SgaT UlaA
HC353_RS08725	COG0039	L-malate dehydrogenase activity
HC353_RS08760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HC353_RS08765	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HC353_RS08770	COG4120	Belongs to the binding-protein-dependent transport system permease family
HC353_RS08785	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HC353_RS08805	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC353_RS08815	COG2222	sugar isomerase
HC353_RS08820	COG3716	PTS system mannose fructose sorbose family IID component
HC353_RS08825	COG3715	PTS system
HC353_RS08850	COG0543	2 iron, 2 sulfur cluster binding
HC353_RS08855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HC353_RS08860	COG0505	Belongs to the CarA family
HC353_RS08865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HC353_RS08870	COG0540	Belongs to the ATCase OTCase family
HC353_RS08875	COG2233	PERMEase
HC353_RS08885	COG0564	pseudouridine synthase activity
HC353_RS08890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HC353_RS08905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HC353_RS08910	COG1278	Cold shock
HC353_RS08920	COG0328	RNA-DNA hybrid ribonuclease activity
HC353_RS08930	COG4684	Psort location CytoplasmicMembrane, score
HC353_RS08935	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HC353_RS08945	COG0513	Belongs to the DEAD box helicase family
HC353_RS08960	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HC353_RS08970	COG0531	amino acid
HC353_RS08975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HC353_RS08980	COG0156	8-amino-7-oxononanoate synthase activity
HC353_RS08985	COG1418	mRNA catabolic process
HC353_RS08990	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HC353_RS08995	COG0116	Belongs to the methyltransferase superfamily
HC353_RS09005	COG3599	regulation of cell shape
HC353_RS09010	COG4474	Belongs to the UPF0398 family
HC353_RS09015	COG3331	DNA recombination
HC353_RS09020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HC353_RS09025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HC353_RS09030	COG3935	DnaD domain protein
HC353_RS09040	COG1846	Transcriptional regulator
HC353_RS09050	COG0446	pyridine nucleotide-disulphide oxidoreductase
HC353_RS09055	COG0735	belongs to the Fur family
HC353_RS09060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HC353_RS09065	COG1705	Flagellar rod assembly protein muramidase FlgJ
HC353_RS09065	COG1388	LysM domain
HC353_RS09080	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HC353_RS09090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC353_RS09095	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HC353_RS09095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HC353_RS09100	COG5416	Lipopolysaccharide assembly protein A domain
HC353_RS09105	COG0300	oxidoreductase activity
HC353_RS09110	COG1234	tRNA 3'-trailer cleavage
HC353_RS09120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HC353_RS09145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC353_RS09150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HC353_RS09155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HC353_RS09160	COG0668	transmembrane transport
HC353_RS09165	COG0517	IMP dehydrogenase activity
HC353_RS09175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HC353_RS09180	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HC353_RS09185	COG0765	amino acid transport
HC353_RS09190	COG0765	amino acid transport
HC353_RS09195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HC353_RS09200	COG1126	abc transporter atp-binding protein
HC353_RS09215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC353_RS09215	COG0072	phenylalanine-tRNA ligase activity
HC353_RS09220	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HC353_RS09225	COG1733	regulation of RNA biosynthetic process
HC353_RS09230	COG1074	ATP-dependent DNA helicase activity
HC353_RS09235	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HC353_RS09240	COG3104	oligopeptide transport
HC353_RS09260	COG4990	cell redox homeostasis
HC353_RS09315	COG3942	CHAP domain
HC353_RS09315	COG1388	LysM domain
HC353_RS09340	COG2151	metal-sulfur cluster biosynthetic enzyme
HC353_RS09345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC353_RS09350	COG1666	GTP binding
HC353_RS09370	COG1968	undecaprenyl-diphosphatase activity
HC353_RS09375	COG2217	Heavy metal translocating P-type atpase
HC353_RS09380	COG2707	UPF0756 membrane protein
HC353_RS09390	COG0268	Binds directly to 16S ribosomal RNA
HC353_RS09395	COG1466	dna polymerase III delta subunit
HC353_RS09400	COG0658	competence protein
HC353_RS09400	COG2333	competence protein COMEC
HC353_RS09405	COG2131	deaminase
HC353_RS09410	COG1555	photosystem II stabilization
HC353_RS09410	COG1596	polysaccharide export
HC353_RS09415	COG3480	Lon protease (S16) C-terminal proteolytic domain
HC353_RS09420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HC353_RS09425	COG0742	ribosomal rna small subunit methyltransferase
HC353_RS09430	COG4471	UPF0298 protein
HC353_RS09445	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HC353_RS09450	COG0772	Belongs to the SEDS family
HC353_RS09455	COG4838	Belongs to the UPF0358 family
HC353_RS09460	COG0514	ATP-dependent DNA helicase (RecQ)
HC353_RS09470	COG0483	inositol monophosphate 1-phosphatase activity
HC353_RS09475	COG4476	Belongs to the UPF0223 family
HC353_RS09495	COG0022	dehydrogenase e1 component
HC353_RS09505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HC353_RS09510	COG0516	GMP reductase activity
HC353_RS09515	COG4214	carbohydrate transport
HC353_RS09525	COG4213	ABC transporter substrate-binding protein
HC353_RS09535	COG2972	Histidine kinase
HC353_RS09545	COG4989	oxidoreductase activity
HC353_RS09550	COG0151	Belongs to the GarS family
HC353_RS09555	COG0138	bifunctional purine biosynthesis protein purh
HC353_RS09560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HC353_RS09565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HC353_RS09575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC353_RS09580	COG0047	phosphoribosylformylglycinamidine synthase activity
HC353_RS09585	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HC353_RS09590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HC353_RS09600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HC353_RS09605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HC353_RS09610	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HC353_RS09620	COG2233	PERMEase
HC353_RS09625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HC353_RS09630	COG0673	inositol 2-dehydrogenase activity
HC353_RS09640	COG0395	ABC-type sugar transport system, permease component
HC353_RS09645	COG1175	transmembrane transport
HC353_RS09650	COG1653	transport
HC353_RS09665	COG1876	peptidase activity
HC353_RS09675	COG0673	inositol 2-dehydrogenase activity
HC353_RS09690	COG2268	Band 7 protein
HC353_RS09700	COG3290	protein histidine kinase activity
HC353_RS09710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HC353_RS09730	COG0436	Aminotransferase
HC353_RS09755	COG1388	LysM domain
HC353_RS09755	COG3942	CHAP domain
HC353_RS09760	COG0084	hydrolase, TatD family'
HC353_RS09765	COG1116	anion transmembrane transporter activity
HC353_RS09775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HC353_RS09780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HC353_RS09790	COG1732	Glycine betaine
HC353_RS09800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC353_RS09810	COG1609	Transcriptional regulator
HC353_RS09815	COG1073	alpha beta
HC353_RS09825	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HC353_RS09840	COG1227	inorganic diphosphatase activity
HC353_RS09845	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HC353_RS09850	COG1882	Formate acetyltransferase
HC353_RS09860	COG0187	DNA topoisomerase II activity
HC353_RS09865	COG1832	CoA-binding protein
HC353_RS09870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HC353_RS09880	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HC353_RS09885	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HC353_RS09890	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HC353_RS09895	COG4974	Belongs to the 'phage' integrase family
HC353_RS09900	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HC353_RS09905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HC353_RS09910	COG0758	DNA mediated transformation
HC353_RS09915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HC353_RS09920	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC353_RS09935	COG0681	Belongs to the peptidase S26 family
HC353_RS09940	COG4479	Belongs to the UPF0346 family
HC353_RS09950	COG4698	Protein conserved in bacteria
HC353_RS09955	COG2755	lipolytic protein G-D-S-L family
HC353_RS09960	COG1307	EDD domain protein, DegV family
HC353_RS09965	COG1272	protein, Hemolysin III
HC353_RS09975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HC353_RS09980	COG0488	(ABC) transporter
HC353_RS09985	COG0025	NhaP-type Na H and K H
HC353_RS10000	COG0617	tRNA 3'-terminal CCA addition
HC353_RS10005	COG1694	Mazg nucleotide pyrophosphohydrolase
HC353_RS10010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HC353_RS10015	COG5582	Belongs to the UPF0302 family
HC353_RS10020	COG0457	Tetratricopeptide repeat
HC353_RS10030	COG0776	regulation of translation
HC353_RS10035	COG1160	GTP binding
HC353_RS10040	COG0539	negative regulation of cytoplasmic translation
HC353_RS10045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HC353_RS10050	COG1388	LysM domain
HC353_RS10050	COG3942	CHAP domain
HC353_RS10055	COG0514	ATP-dependent DNA helicase (RecQ)
HC353_RS10075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HC353_RS10080	COG1288	antiporter activity
HC353_RS10085	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HC353_RS10090	COG1187	pseudouridine synthase activity
HC353_RS10095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HC353_RS10100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HC353_RS10110	COG4974	Belongs to the 'phage' integrase family
HC353_RS10115	COG0735	belongs to the Fur family
HC353_RS10120	COG2996	Protein conserved in bacteria
HC353_RS10130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HC353_RS10135	COG0358	DNA primase activity
HC353_RS10140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC353_RS10150	COG0741	lytic transglycosylase activity
HC353_RS10155	COG0596	Alpha beta hydrolase
HC353_RS10160	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HC353_RS10160	COG0392	lysyltransferase activity
HC353_RS10180	COG0656	L-ascorbic acid biosynthetic process
HC353_RS10200	COG0183	Belongs to the thiolase family
HC353_RS10210	COG3425	synthase
HC353_RS10220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HC353_RS10225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HC353_RS10230	COG0351	phosphomethylpyrimidine kinase
HC353_RS10240	COG1393	Belongs to the ArsC family
HC353_RS10255	COG0589	response to stress
HC353_RS10260	COG2723	6-phospho-beta-galactosidase activity
HC353_RS10265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS10270	COG2188	Transcriptional regulator
HC353_RS10275	COG0346	lactoylglutathione lyase activity
HC353_RS10280	COG0400	carboxylic ester hydrolase activity
HC353_RS10295	COG3775	system Galactitol-specific IIC component
HC353_RS10305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS10305	COG2213	PTS system mannitol-specific
HC353_RS10310	COG1349	DNA-binding transcription factor activity
HC353_RS10315	COG1105	Belongs to the carbohydrate kinase PfkB family
HC353_RS10320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HC353_RS10325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS10325	COG3711	transcriptional antiterminator
HC353_RS10330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS10330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS10330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS10340	COG3623	hexulose-6-phosphate isomerase
HC353_RS10345	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HC353_RS10370	COG1349	DNA-binding transcription factor activity
HC353_RS10385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS10385	COG1263	PTS System
HC353_RS10390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC353_RS10415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS10515	COG5002	protein histidine kinase activity
HC353_RS10520	COG0745	RESPONSE REGULATOR receiver
HC353_RS10525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HC353_RS10530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HC353_RS10540	COG0583	DNA-binding transcription factor activity
HC353_RS10550	COG0205	6-phosphofructokinase activity
HC353_RS10555	COG0587	DNA-directed DNA polymerase activity
HC353_RS10565	COG2814	Major facilitator Superfamily
HC353_RS10570	COG2252	PERMEase
HC353_RS10575	COG0561	phosphatase activity
HC353_RS10580	COG0768	penicillin binding
HC353_RS10585	COG1737	Transcriptional regulator
HC353_RS10590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HC353_RS10595	COG1942	4-Oxalocrotonate Tautomerase
HC353_RS10605	COG3973	AAA domain
HC353_RS10615	COG0217	transcriptional regulatory protein
HC353_RS10620	COG1323	Belongs to the UPF0348 family
HC353_RS10625	COG2226	methyltransferase
HC353_RS10630	COG0799	negative regulation of ribosome biogenesis
HC353_RS10635	COG1713	HD superfamily hydrolase involved in NAD metabolism
HC353_RS10640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HC353_RS10645	COG1534	Rna-binding protein
HC353_RS10650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HC353_RS10655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HC353_RS10660	COG0825	malonyl-CoA metabolic process
HC353_RS10665	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HC353_RS10670	COG0439	Biotin carboxylase
HC353_RS10675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HC353_RS10685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HC353_RS10690	COG1028	Short-chain dehydrogenase reductase Sdr
HC353_RS10695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HC353_RS10705	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HC353_RS10710	COG1846	Transcriptional regulator
HC353_RS10715	COG0322	excinuclease ABC activity
HC353_RS10720	COG4703	Protein of unknown function (DUF1797)
HC353_RS10725	COG2084	Dehydrogenase
HC353_RS10730	COG0438	transferase activity, transferring glycosyl groups
HC353_RS10740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HC353_RS10745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS10750	COG0542	response to heat
HC353_RS10765	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HC353_RS10770	COG1253	flavin adenine dinucleotide binding
HC353_RS10775	COG0628	permease
HC353_RS10785	COG3557	Belongs to the UPF0374 family
HC353_RS10795	COG2137	regulation of response to DNA damage stimulus
HC353_RS10800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HC353_RS10805	COG3397	chitin binding
HC353_RS10815	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HC353_RS10820	COG1316	TRANSCRIPTIONal
HC353_RS10825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC353_RS10860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HC353_RS10865	COG2246	polysaccharide biosynthetic process
HC353_RS10895	COG0860	N-Acetylmuramoyl-L-alanine amidase
HC353_RS10895	COG1388	LysM domain
HC353_RS10905	COG4585	Histidine kinase
HC353_RS10915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HC353_RS10920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HC353_RS10945	COG3475	LICD family
HC353_RS10955	COG1216	Glycosyl transferase, family 2
HC353_RS10970	COG3475	LICD family
HC353_RS10975	COG1216	Glycosyl transferase, family 2
HC353_RS10980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HC353_RS10985	COG0438	transferase activity, transferring glycosyl groups
HC353_RS10985	COG1216	Glycosyl transferase, family 2
HC353_RS10990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC353_RS11000	COG1682	transport, permease protein
HC353_RS11015	COG1091	dTDP-4-dehydrorhamnose reductase activity
HC353_RS11020	COG1088	dTDP-glucose 4,6-dehydratase activity
HC353_RS11025	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HC353_RS11030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HC353_RS11035	COG1215	transferase activity, transferring glycosyl groups
HC353_RS11050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HC353_RS11055	COG1295	ribonuclease BN
HC353_RS11060	COG0024	Methionine aminopeptidase
HC353_RS11065	COG0716	FMN binding
HC353_RS11075	COG2309	aminopeptidase activity
HC353_RS11115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS11120	COG1447	Phosphotransferase system cellobiose-specific component IIA
HC353_RS11125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS11130	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC353_RS11130	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC353_RS11135	COG0513	Belongs to the DEAD box helicase family
HC353_RS11140	COG0673	inositol 2-dehydrogenase activity
HC353_RS11160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HC353_RS11165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HC353_RS11170	COG3599	regulation of cell shape
HC353_RS11175	COG2302	S4 RNA-binding domain
HC353_RS11185	COG1799	cell septum assembly
HC353_RS11190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HC353_RS11225	COG0768	penicillin binding
HC353_RS11260	COG0497	DNA recombination
HC353_RS11265	COG1438	arginine binding
HC353_RS11270	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HC353_RS11280	COG1722	exodeoxyribonuclease VII activity
HC353_RS11285	COG1570	exodeoxyribonuclease VII activity
HC353_RS11290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HC353_RS11295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HC353_RS11300	COG1302	Protein conserved in bacteria
HC353_RS11305	COG0006	proline dipeptidase activity
HC353_RS11310	COG2261	transglycosylase associated protein
HC353_RS11320	COG3716	PTS system mannose fructose sorbose family IID component
HC353_RS11325	COG3715	PTS system
HC353_RS11335	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS11335	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HC353_RS11340	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC353_RS11340	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC353_RS11345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HC353_RS11355	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HC353_RS11365	COG0659	secondary active sulfate transmembrane transporter activity
HC353_RS11370	COG3759	membrane
HC353_RS11395	COG0095	Lipoate-protein ligase
HC353_RS11400	COG1234	tRNA 3'-trailer cleavage
HC353_RS11410	COG1363	Peptidase, m42
HC353_RS11415	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HC353_RS11420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HC353_RS11425	COG1696	Membrane protein involved in D-alanine export
HC353_RS11430	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HC353_RS11445	COG1136	(ABC) transporter
HC353_RS11450	COG1328	CTP reductase activity
HC353_RS11455	COG0602	queuosine metabolic process
HC353_RS11470	COG4467	Involved in initiation control of chromosome replication
HC353_RS11475	COG1774	PSP1 C-terminal conserved region
HC353_RS11480	COG0470	DNA polymerase III
HC353_RS11485	COG3870	Protein conserved in bacteria
HC353_RS11490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HC353_RS11495	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HC353_RS11500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HC353_RS11505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HC353_RS11525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC353_RS11535	COG2814	Major facilitator Superfamily
HC353_RS11545	COG1349	DNA-binding transcription factor activity
HC353_RS11555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS11555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HC353_RS11620	COG0254	rRNA binding
HC353_RS11625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HC353_RS11630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HC353_RS11640	COG0504	CTP synthase activity
HC353_RS11650	COG0789	Transcriptional regulator
HC353_RS11655	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HC353_RS11660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HC353_RS11665	COG0584	glycerophosphoryl diester phosphodiesterase
HC353_RS11675	COG0740	serine-type endopeptidase activity
HC353_RS11680	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HC353_RS11690	COG1132	(ABC) transporter
HC353_RS11710	COG1278	Cold shock
HC353_RS11715	COG2003	Belongs to the UPF0758 family
HC353_RS11720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HC353_RS11725	COG0285	dihydrofolate synthase activity
HC353_RS11730	COG0525	valine-tRNA ligase activity
HC353_RS11735	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HC353_RS11740	COG0301	tRNA thio-modification
HC353_RS11745	COG1104	cysteine desulfurase activity
HC353_RS11750	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HC353_RS11760	COG0561	phosphatase activity
HC353_RS11765	COG1801	Protein of unknown function DUF72
HC353_RS11785	COG3579	cysteine-type endopeptidase activity
HC353_RS11855	COG1098	S1 RNA binding domain
HC353_RS11860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HC353_RS11870	COG0492	ferredoxin-NADP+ reductase activity
HC353_RS11875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HC353_RS11890	COG4470	Protein conserved in bacteria
HC353_RS11895	COG0737	Belongs to the 5'-nucleotidase family
HC353_RS11905	COG0590	tRNA wobble adenosine to inosine editing
HC353_RS11910	COG2508	Transcriptional regulator
HC353_RS11920	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HC353_RS11920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HC353_RS11935	COG2738	Putative neutral zinc metallopeptidase
HC353_RS11940	COG2824	Alkylphosphonate utilization operon protein PhnA
HC353_RS11945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HC353_RS11950	COG4109	DRTGG domain
HC353_RS11955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HC353_RS11970	COG0577	efflux transmembrane transporter activity
HC353_RS11975	COG1136	(ABC) transporter
HC353_RS11985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HC353_RS11990	COG1288	antiporter activity
HC353_RS11995	COG4821	SIS domain
HC353_RS12010	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HC353_RS12025	COG3397	chitin binding
HC353_RS12035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HC353_RS12040	COG3716	PTS system mannose fructose sorbose family IID component
HC353_RS12045	COG3715	PTS system
HC353_RS12060	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HC353_RS12060	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HC353_RS12075	COG1132	(ABC) transporter
HC353_RS12080	COG1132	(ABC) transporter
HC353_RS12090	COG1803	Methylglyoxal synthase
HC353_RS12095	COG3842	ATPase activity
HC353_RS12105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HC353_RS12110	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HC353_RS12115	COG0084	hydrolase, TatD family'
HC353_RS12120	COG0531	amino acid
HC353_RS12135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC353_RS12135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HC353_RS12150	COG0675	Transposase, IS605 OrfB family
HC353_RS12155	COG4608	Belongs to the ABC transporter superfamily
HC353_RS12160	COG0444	Belongs to the ABC transporter superfamily
HC353_RS12165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HC353_RS12170	COG0601	transmembrane transport
HC353_RS12180	COG4166	transmembrane transport
HC353_RS12195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HC353_RS12200	COG1674	ftsk spoiiie
HC353_RS12205	COG2723	6-phospho-beta-galactosidase activity
HC353_RS12215	COG1126	abc transporter atp-binding protein
HC353_RS12220	COG0765	amino acid transport
HC353_RS12250	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HC353_RS12260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HC353_RS12265	COG0009	L-threonylcarbamoyladenylate synthase
HC353_RS12270	COG2890	protein-(glutamine-N5) methyltransferase activity
HC353_RS12275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HC353_RS12280	COG1435	thymidine kinase activity
HC353_RS12285	COG2226	methyltransferase
HC353_RS12290	COG0681	Belongs to the peptidase S26 family
HC353_RS12310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HC353_RS12315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HC353_RS12320	COG3442	glutamine amidotransferase
HC353_RS12325	COG0246	Mannitol dehydrogenase
HC353_RS12330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS12335	COG2213	PTS system mannitol-specific
HC353_RS12345	COG1131	(ABC) transporter
HC353_RS12355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS12360	COG3711	transcriptional antiterminator
HC353_RS12370	COG1482	cell wall glycoprotein biosynthetic process
HC353_RS12385	COG1132	(ABC) transporter
HC353_RS12405	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HC353_RS12410	COG0628	permease
HC353_RS12420	COG2706	6-phosphogluconolactonase activity
HC353_RS12435	COG1368	sulfuric ester hydrolase activity
HC353_RS12440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HC353_RS12445	COG2160	L-arabinose isomerase activity
HC353_RS12450	COG0235	Class ii aldolase
HC353_RS12470	COG3940	Belongs to the glycosyl hydrolase 43 family
HC353_RS12475	COG3534	alpha-L-arabinofuranosidase
HC353_RS12485	COG0395	ABC-type sugar transport system, permease component
HC353_RS12490	COG1175	transmembrane transport
HC353_RS12510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HC353_RS12515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HC353_RS12555	COG0789	Transcriptional regulator
HC353_RS12560	COG1609	Transcriptional regulator
HC353_RS12570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HC353_RS12640	COG0741	lytic transglycosylase activity
HC353_RS12640	COG0739	heme binding
HC353_RS12640	COG1196	nuclear chromosome segregation
HC353_RS12840	COG3561	AntA/AntB antirepressor
HC353_RS12850	COG1396	sequence-specific DNA binding
HC353_RS12870	COG0582	viral genome integration into host DNA
HC353_RS12875	COG3328	transposase activity
HC353_RS12880	COG0582	viral genome integration into host DNA
HC353_RS12885	COG4974	Belongs to the 'phage' integrase family
HC353_RS12920	COG0390	transport system, permease component
HC353_RS12925	COG4619	ABC transporter
HC353_RS12930	COG0662	Cupin 2, conserved barrel domain protein
HC353_RS12935	COG3328	transposase activity
HC353_RS12955	COG0071	Belongs to the small heat shock protein (HSP20) family
HC353_RS12975	COG3328	transposase activity
HC353_RS12995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HC353_RS13085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HC353_RS13085	COG3711	transcriptional antiterminator
HC353_RS13090	COG0800	Aldolase
HC353_RS13095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HC353_RS13120	COG1063	alcohol dehydrogenase
HC353_RS13135	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HC353_RS13145	COG1733	regulation of RNA biosynthetic process
HC353_RS13180	COG0629	single-stranded DNA binding
HC353_RS13405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HC353_RS13415	COG0783	Belongs to the Dps family
HC353_RS13420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HC353_RS13425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HC353_RS13430	COG2217	Heavy metal translocating P-type atpase
HC353_RS13450	COG1215	transferase activity, transferring glycosyl groups
HC353_RS13460	COG0640	Transcriptional regulator
HC353_RS13465	COG2217	Heavy metal translocating P-type atpase
HC353_RS13490	COG2188	Transcriptional regulator
HC353_RS13500	COG1288	antiporter activity
HC353_RS13535	COG1404	Belongs to the peptidase S8 family
HC353_RS13570	COG1401	restriction endodeoxyribonuclease activity