locus-tag	class	description
B6S06_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B6S06_RS00010	COG0592	DNA-directed DNA polymerase activity
B6S06_RS00015	COG2501	S4 domain
B6S06_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6S06_RS00025	COG0187	DNA topoisomerase II activity
B6S06_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
B6S06_RS00040	COG0629	single-stranded DNA binding
B6S06_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B6S06_RS00055	COG0359	binds to the 23S rRNA
B6S06_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
B6S06_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6S06_RS00075	COG0488	(ABC) transporter
B6S06_RS00085	COG0028	Belongs to the TPP enzyme family
B6S06_RS00160	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS00170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS00170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS00180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B6S06_RS00180	COG0519	Catalyzes the synthesis of GMP from XMP
B6S06_RS00185	COG1072	(Pantothenic acid kinase))
B6S06_RS00190	COG2813	Specifically methylates the guanine in position
B6S06_RS00195	COG1609	Transcriptional regulator
B6S06_RS00200	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B6S06_RS00205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B6S06_RS00210	COG0295	cytidine deaminase activity
B6S06_RS00215	COG1744	ABC transporter substrate-binding protein PnrA-like
B6S06_RS00220	COG3845	ABC transporter
B6S06_RS00225	COG4603	Belongs to the binding-protein-dependent transport system permease family
B6S06_RS00230	COG1079	Belongs to the binding-protein-dependent transport system permease family
B6S06_RS00235	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B6S06_RS00245	COG0813	purine-nucleoside phosphorylase activity
B6S06_RS00255	COG0588	phosphoglycerate mutase activity
B6S06_RS00265	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B6S06_RS00270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B6S06_RS00275	COG0049	tRNA binding
B6S06_RS00280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6S06_RS00285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B6S06_RS00290	COG0051	transcription antitermination factor activity, RNA binding
B6S06_RS00295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B6S06_RS00300	COG0088	Forms part of the polypeptide exit tunnel
B6S06_RS00305	COG0089	rRNA binding
B6S06_RS00310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6S06_RS00320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B6S06_RS00325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6S06_RS00330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B6S06_RS00335	COG0255	Belongs to the universal ribosomal protein uL29 family
B6S06_RS00340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B6S06_RS00345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B6S06_RS00350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B6S06_RS00355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6S06_RS00360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6S06_RS00365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6S06_RS00370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6S06_RS00375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B6S06_RS00380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B6S06_RS00385	COG1841	ribosomal large subunit assembly
B6S06_RS00390	COG0200	Binds to the 23S rRNA
B6S06_RS00395	COG0201	protein transport
B6S06_RS00400	COG0563	adenylate kinase activity
B6S06_RS00405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B6S06_RS00410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B6S06_RS00415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6S06_RS00420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B6S06_RS00425	COG0202	RNA polymerase activity
B6S06_RS00430	COG0203	ribosomal protein L17
B6S06_RS00435	COG1122	ATPase activity
B6S06_RS00440	COG1122	ATPase activity
B6S06_RS00455	COG0101	tRNA pseudouridine synthase activity
B6S06_RS00465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6S06_RS00480	COG1461	Dihydroxyacetone kinase
B6S06_RS00485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B6S06_RS00490	COG0416	fatty acid biosynthetic process
B6S06_RS00495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6S06_RS00505	COG4608	Belongs to the ABC transporter superfamily
B6S06_RS00510	COG0601	transmembrane transport
B6S06_RS00530	COG0571	ribonuclease III activity
B6S06_RS00535	COG1196	nuclear chromosome segregation
B6S06_RS00540	COG0561	phosphatase activity
B6S06_RS00545	COG0552	protein localization to endoplasmic reticulum
B6S06_RS00550	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6S06_RS00550	COG2918	glutathione biosynthetic process
B6S06_RS00560	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6S06_RS00565	COG4605	iron ion homeostasis
B6S06_RS00570	COG4604	ABC transporter, ATP-binding protein
B6S06_RS00575	COG4607	ABC-type enterochelin transport system periplasmic component
B6S06_RS00595	COG3328	transposase activity
B6S06_RS00605	COG4886	Leucine-rich repeat (LRR) protein
B6S06_RS00605	COG4932	domain protein
B6S06_RS00620	COG3328	transposase activity
B6S06_RS00640	COG1380	Effector of murein hydrolase LrgA
B6S06_RS00660	COG1028	Short-chain dehydrogenase reductase Sdr
B6S06_RS00670	COG1268	BioY protein
B6S06_RS00675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6S06_RS00690	COG0561	phosphatase activity
B6S06_RS00700	COG1692	metallophosphoesterase
B6S06_RS00710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B6S06_RS00720	COG0424	maF-like protein
B6S06_RS00725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS00725	COG1263	PTS System
B6S06_RS00730	COG2188	Transcriptional regulator
B6S06_RS00740	COG0632	four-way junction helicase activity
B6S06_RS00745	COG2255	four-way junction helicase activity
B6S06_RS00755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B6S06_RS00765	COG3328	transposase activity
B6S06_RS00775	COG1114	Component of the transport system for branched-chain amino acids
B6S06_RS00785	COG1113	amino acid transport
B6S06_RS00790	COG1126	abc transporter atp-binding protein
B6S06_RS00795	COG0765	amino acid transport
B6S06_RS00810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6S06_RS00815	COG0110	maltose O-acetyltransferase activity
B6S06_RS00820	COG1827	regulation of RNA biosynthetic process
B6S06_RS00830	COG0242	peptide deformylase activity
B6S06_RS00835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B6S06_RS00840	COG1185	polyribonucleotide nucleotidyltransferase activity
B6S06_RS00855	COG3158	transport of potassium into the cell
B6S06_RS00860	COG1253	flavin adenine dinucleotide binding
B6S06_RS00865	COG0534	Mate efflux family protein
B6S06_RS00875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B6S06_RS00880	COG1187	pseudouridine synthase activity
B6S06_RS00885	COG1011	Hydrolase
B6S06_RS00890	COG0572	uridine kinase
B6S06_RS00920	COG1671	Belongs to the UPF0178 family
B6S06_RS00930	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6S06_RS00935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6S06_RS00945	COG0736	holo-[acyl-carrier-protein] synthase activity
B6S06_RS00950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B6S06_RS00955	COG2337	Toxic component of a toxin-antitoxin (TA) module
B6S06_RS00965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6S06_RS00970	COG0604	alcohol dehydrogenase
B6S06_RS00970	COG3321	synthase
B6S06_RS00985	COG0531	amino acid
B6S06_RS01015	COG1174	glycine betaine transport
B6S06_RS01035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B6S06_RS01050	COG0343	queuine tRNA-ribosyltransferase activity
B6S06_RS01055	COG1862	Preprotein translocase
B6S06_RS01065	COG1012	belongs to the aldehyde dehydrogenase family
B6S06_RS01065	COG1454	alcohol dehydrogenase
B6S06_RS01070	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B6S06_RS01100	COG2207	Transcriptional regulator
B6S06_RS01100	COG1917	Cupin 2, conserved barrel domain protein
B6S06_RS01105	COG1070	Carbohydrate kinase
B6S06_RS01110	COG4806	L-rhamnose isomerase
B6S06_RS01115	COG0235	Class ii aldolase
B6S06_RS01120	COG3254	rhamnose metabolic process
B6S06_RS01125	COG1454	alcohol dehydrogenase
B6S06_RS01130	COG1414	Transcriptional regulator
B6S06_RS01135	COG0800	Aldolase
B6S06_RS01145	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B6S06_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
B6S06_RS01155	COG1304	FMN binding
B6S06_RS01170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B6S06_RS01175	COG1428	Deoxynucleoside kinase
B6S06_RS01190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B6S06_RS01195	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B6S06_RS01200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B6S06_RS01230	COG0824	Thioesterase
B6S06_RS01235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B6S06_RS01255	COG1363	Peptidase, m42
B6S06_RS01260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6S06_RS01265	COG0589	response to stress
B6S06_RS01270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6S06_RS01275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6S06_RS01280	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B6S06_RS01335	COG1368	sulfuric ester hydrolase activity
B6S06_RS01345	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B6S06_RS01355	COG0101	tRNA pseudouridine synthase activity
B6S06_RS01380	COG0667	Aldo Keto reductase
B6S06_RS01385	COG2186	Transcriptional regulator
B6S06_RS01390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS01395	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS01405	COG1447	Phosphotransferase system cellobiose-specific component IIA
B6S06_RS01410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS01425	COG1063	alcohol dehydrogenase
B6S06_RS01435	COG4716	Myosin-crossreactive antigen
B6S06_RS01475	COG1113	amino acid transport
B6S06_RS01505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B6S06_RS01515	COG3052	prosthetic group binding
B6S06_RS01590	COG1051	belongs to the nudix hydrolase family
B6S06_RS01595	COG1846	Transcriptional regulator
B6S06_RS01620	COG2252	PERMEase
B6S06_RS01625	COG0366	Alpha amylase catalytic
B6S06_RS01630	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS01640	COG1263	PTS System
B6S06_RS01640	COG2190	(PTS) system
B6S06_RS01640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS01645	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS01660	COG1902	pentaerythritol trinitrate reductase activity
B6S06_RS01670	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6S06_RS01680	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6S06_RS01685	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B6S06_RS01690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B6S06_RS01700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6S06_RS01720	COG1937	Protein conserved in bacteria
B6S06_RS01725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B6S06_RS01730	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6S06_RS01735	COG3973	AAA domain
B6S06_RS01760	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
B6S06_RS01765	COG2376	Dihydroxyacetone kinase
B6S06_RS01770	COG1461	Dihydroxyacetone kinase
B6S06_RS01785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6S06_RS01795	COG1131	(ABC) transporter
B6S06_RS01800	COG1309	transcriptional regulator
B6S06_RS01820	COG0531	amino acid
B6S06_RS01825	COG1757	Na H antiporter
B6S06_RS01830	COG1609	Transcriptional regulator
B6S06_RS01840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6S06_RS01850	COG1263	PTS System
B6S06_RS01850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS01850	COG2190	(PTS) system
B6S06_RS01880	COG3479	Phenolic acid decarboxylase
B6S06_RS01885	COG1695	Transcriptional regulator
B6S06_RS01895	COG2814	Major facilitator Superfamily
B6S06_RS01925	COG0163	prenyltransferase activity
B6S06_RS01930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B6S06_RS01940	COG1136	(ABC) transporter
B6S06_RS01940	COG0577	efflux transmembrane transporter activity
B6S06_RS01960	COG1811	Na channel or pump
B6S06_RS01995	COG1136	(ABC) transporter
B6S06_RS02010	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6S06_RS02010	COG3942	CHAP domain
B6S06_RS02015	COG1263	PTS System
B6S06_RS02015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS02015	COG2190	(PTS) system
B6S06_RS02020	COG1869	D-ribose catabolic process
B6S06_RS02030	COG1609	Transcriptional regulator
B6S06_RS02055	COG0366	Alpha amylase catalytic
B6S06_RS02065	COG0628	permease
B6S06_RS02070	COG0803	Belongs to the bacterial solute-binding protein 9 family
B6S06_RS02070	COG3443	Belongs to the bacterial solute-binding protein 9 family
B6S06_RS02095	COG1428	Deoxynucleoside kinase
B6S06_RS02110	COG0210	DNA helicase
B6S06_RS02115	COG1393	Belongs to the ArsC family
B6S06_RS02120	COG1393	Belongs to the ArsC family
B6S06_RS02150	COG0386	Belongs to the glutathione peroxidase family
B6S06_RS02155	COG1854	S-ribosylhomocysteine lyase activity
B6S06_RS02170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6S06_RS02185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B6S06_RS02190	COG0019	diaminopimelate decarboxylase activity
B6S06_RS02195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B6S06_RS02205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B6S06_RS02210	COG2171	N-acyltransferase activity
B6S06_RS02215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B6S06_RS02220	COG0527	aspartate kinase activity
B6S06_RS02225	COG1473	amidohydrolase
B6S06_RS02230	COG0436	Aminotransferase
B6S06_RS02235	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6S06_RS02255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6S06_RS02260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B6S06_RS02275	COG2207	Transcriptional regulator
B6S06_RS02280	COG2249	NAD(P)H dehydrogenase (quinone) activity
B6S06_RS02290	COG1113	amino acid transport
B6S06_RS02295	COG1121	(ABC) transporter
B6S06_RS02300	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6S06_RS02315	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B6S06_RS02320	COG2823	Periplasmic or secreted lipoprotein
B6S06_RS02320	COG1652	LysM domain
B6S06_RS02330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6S06_RS02335	COG0477	Major facilitator Superfamily
B6S06_RS02345	COG1438	arginine binding
B6S06_RS02360	COG1764	response to oxidative stress
B6S06_RS02365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6S06_RS02370	COG1335	isochorismatase
B6S06_RS02400	COG2135	peptidase activity
B6S06_RS02450	COG3546	catalase activity
B6S06_RS02460	COG1175	transmembrane transport
B6S06_RS02465	COG0395	ABC-type sugar transport system, permease component
B6S06_RS02505	COG0745	RESPONSE REGULATOR receiver
B6S06_RS02510	COG2205	protein histidine kinase activity
B6S06_RS02515	COG4975	Glucose uptake
B6S06_RS02520	COG0531	amino acid
B6S06_RS02525	COG3853	Toxic anion resistance protein (TelA)
B6S06_RS02545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B6S06_RS02550	COG1335	isochorismatase
B6S06_RS02565	COG3590	peptidase
B6S06_RS02575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6S06_RS02580	COG1104	cysteine desulfurase activity
B6S06_RS02600	COG0482	sulfurtransferase activity
B6S06_RS02610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6S06_RS02615	COG2814	Major facilitator Superfamily
B6S06_RS02635	COG0463	Glycosyl transferase, family 2
B6S06_RS02640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6S06_RS02645	COG2855	membrane
B6S06_RS02660	COG0583	DNA-binding transcription factor activity
B6S06_RS02670	COG0772	Belongs to the SEDS family
B6S06_RS02675	COG1393	Belongs to the ArsC family
B6S06_RS02680	COG0509	glycine decarboxylation via glycine cleavage system
B6S06_RS02685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6S06_RS02690	COG2011	ABC-type metal ion transport system permease component
B6S06_RS02695	COG1464	Belongs to the NlpA lipoprotein family
B6S06_RS02705	COG0719	Fe-S assembly protein
B6S06_RS02710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6S06_RS02720	COG0719	Fe-S assembly protein
B6S06_RS02785	COG2190	(PTS) system
B6S06_RS02785	COG1263	PTS System
B6S06_RS02785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS02790	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS02795	COG3711	transcriptional antiterminator
B6S06_RS02815	COG3850	Histidine kinase
B6S06_RS02815	COG5002	protein histidine kinase activity
B6S06_RS02830	COG0737	Belongs to the 5'-nucleotidase family
B6S06_RS02835	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B6S06_RS02840	COG3639	organic phosphonate transmembrane transporter activity
B6S06_RS02855	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B6S06_RS02865	COG1744	ABC transporter substrate-binding protein PnrA-like
B6S06_RS02875	COG3328	transposase activity
B6S06_RS02935	COG1136	(ABC) transporter
B6S06_RS02935	COG0577	efflux transmembrane transporter activity
B6S06_RS02940	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B6S06_RS02950	COG1597	lipid kinase activity
B6S06_RS02965	COG4372	Transposase
B6S06_RS03015	COG3764	Sortase (surface protein transpeptidase)
B6S06_RS03025	COG1263	PTS System
B6S06_RS03025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS03025	COG2190	(PTS) system
B6S06_RS03030	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS03035	COG2188	Transcriptional regulator
B6S06_RS03060	COG1611	Belongs to the LOG family
B6S06_RS03070	COG1428	Deoxynucleoside kinase
B6S06_RS03090	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS03110	COG1368	sulfuric ester hydrolase activity
B6S06_RS03120	COG0105	UTP biosynthetic process
B6S06_RS03125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6S06_RS03130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6S06_RS03140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6S06_RS03145	COG2011	ABC-type metal ion transport system permease component
B6S06_RS03150	COG1464	Belongs to the NlpA lipoprotein family
B6S06_RS03160	COG1757	Na H antiporter
B6S06_RS03180	COG1113	amino acid transport
B6S06_RS03190	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B6S06_RS03195	COG1929	Belongs to the glycerate kinase type-1 family
B6S06_RS03200	COG0488	(ABC) transporter
B6S06_RS03215	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B6S06_RS03220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS03220	COG1263	PTS System
B6S06_RS03235	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B6S06_RS03240	COG1131	(ABC) transporter
B6S06_RS03260	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B6S06_RS03285	COG0346	lactoylglutathione lyase activity
B6S06_RS03310	COG0561	phosphatase activity
B6S06_RS03315	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B6S06_RS03320	COG0280	phosphate acetyltransferase
B6S06_RS03325	COG0802	atpase or kinase
B6S06_RS03330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6S06_RS03355	COG0708	Exodeoxyribonuclease III
B6S06_RS03365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B6S06_RS03400	COG1053	succinate dehydrogenase
B6S06_RS03410	COG1028	Short-chain dehydrogenase reductase Sdr
B6S06_RS03410	COG3321	synthase
B6S06_RS03410	COG0604	alcohol dehydrogenase
B6S06_RS03415	COG0702	epimerase
B6S06_RS03420	COG4684	Psort location CytoplasmicMembrane, score
B6S06_RS03425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B6S06_RS03430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B6S06_RS03435	COG0604	alcohol dehydrogenase
B6S06_RS03445	COG3842	ATPase activity
B6S06_RS03450	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6S06_RS03455	COG1177	transmembrane transport
B6S06_RS03460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B6S06_RS03465	COG3829	transcription factor binding
B6S06_RS03480	COG3715	PTS system
B6S06_RS03485	COG3716	PTS system mannose fructose sorbose family IID component
B6S06_RS03500	COG1940	carbohydrate kinase activity
B6S06_RS03540	COG0582	viral genome integration into host DNA
B6S06_RS03550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B6S06_RS03560	COG0789	Transcriptional regulator
B6S06_RS03580	COG0504	CTP synthase activity
B6S06_RS03595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B6S06_RS03600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B6S06_RS03605	COG0254	rRNA binding
B6S06_RS03630	COG1349	DNA-binding transcription factor activity
B6S06_RS03640	COG2814	Major facilitator Superfamily
B6S06_RS03650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6S06_RS03670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B6S06_RS03675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B6S06_RS03680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B6S06_RS03685	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6S06_RS03690	COG3870	Protein conserved in bacteria
B6S06_RS03695	COG0470	DNA polymerase III
B6S06_RS03700	COG1774	PSP1 C-terminal conserved region
B6S06_RS03705	COG4467	Involved in initiation control of chromosome replication
B6S06_RS03720	COG0602	queuosine metabolic process
B6S06_RS03725	COG1328	CTP reductase activity
B6S06_RS03730	COG1136	(ABC) transporter
B6S06_RS03735	COG0577	efflux transmembrane transporter activity
B6S06_RS03750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6S06_RS03755	COG1696	Membrane protein involved in D-alanine export
B6S06_RS03760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6S06_RS03765	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B6S06_RS03770	COG1363	Peptidase, m42
B6S06_RS03780	COG1234	tRNA 3'-trailer cleavage
B6S06_RS03785	COG0095	Lipoate-protein ligase
B6S06_RS03810	COG3759	membrane
B6S06_RS03815	COG0659	secondary active sulfate transmembrane transporter activity
B6S06_RS03825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B6S06_RS03835	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B6S06_RS03840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B6S06_RS03840	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B6S06_RS03845	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6S06_RS03845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS03855	COG3715	PTS system
B6S06_RS03860	COG3716	PTS system mannose fructose sorbose family IID component
B6S06_RS03870	COG2261	transglycosylase associated protein
B6S06_RS03875	COG0006	proline dipeptidase activity
B6S06_RS03880	COG1302	Protein conserved in bacteria
B6S06_RS03885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6S06_RS03890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6S06_RS03895	COG1570	exodeoxyribonuclease VII activity
B6S06_RS03900	COG1722	exodeoxyribonuclease VII activity
B6S06_RS03910	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B6S06_RS03915	COG1438	arginine binding
B6S06_RS03920	COG0497	DNA recombination
B6S06_RS03955	COG0768	penicillin binding
B6S06_RS03990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B6S06_RS03995	COG1799	cell septum assembly
B6S06_RS04005	COG2302	S4 RNA-binding domain
B6S06_RS04010	COG3599	regulation of cell shape
B6S06_RS04015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B6S06_RS04020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B6S06_RS04040	COG0673	inositol 2-dehydrogenase activity
B6S06_RS04045	COG0513	Belongs to the DEAD box helicase family
B6S06_RS04050	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B6S06_RS04050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B6S06_RS04055	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS04060	COG1447	Phosphotransferase system cellobiose-specific component IIA
B6S06_RS04065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS04120	COG1396	sequence-specific DNA binding
B6S06_RS04400	COG2309	aminopeptidase activity
B6S06_RS04410	COG0716	FMN binding
B6S06_RS04415	COG0024	Methionine aminopeptidase
B6S06_RS04420	COG1295	ribonuclease BN
B6S06_RS04425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B6S06_RS04440	COG1215	transferase activity, transferring glycosyl groups
B6S06_RS04445	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B6S06_RS04455	COG1088	dTDP-glucose 4,6-dehydratase activity
B6S06_RS04460	COG1091	dTDP-4-dehydrorhamnose reductase activity
B6S06_RS04475	COG1682	transport, permease protein
B6S06_RS04485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6S06_RS04490	COG0438	transferase activity, transferring glycosyl groups
B6S06_RS04490	COG1216	Glycosyl transferase, family 2
B6S06_RS04500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B6S06_RS04505	COG0463	Glycosyl transferase, family 2
B6S06_RS04510	COG0438	transferase activity, transferring glycosyl groups
B6S06_RS04535	COG1086	Polysaccharide biosynthesis protein
B6S06_RS04540	COG2089	acid synthase
B6S06_RS04545	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B6S06_RS04555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B6S06_RS04570	COG1083	cytidylyl-transferase
B6S06_RS04600	COG3328	transposase activity
B6S06_RS04615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B6S06_RS04620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B6S06_RS04630	COG4585	Histidine kinase
B6S06_RS04640	COG0569	domain protein
B6S06_RS04665	COG2246	polysaccharide biosynthetic process
B6S06_RS04670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B6S06_RS04680	COG1316	TRANSCRIPTIONal
B6S06_RS04685	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B6S06_RS04690	COG3397	chitin binding
B6S06_RS04695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6S06_RS04700	COG2137	regulation of response to DNA damage stimulus
B6S06_RS04705	COG1194	a g-specific adenine glycosylase
B6S06_RS04710	COG3557	Belongs to the UPF0374 family
B6S06_RS04720	COG0628	permease
B6S06_RS04725	COG1253	flavin adenine dinucleotide binding
B6S06_RS04735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B6S06_RS04760	COG0542	response to heat
B6S06_RS04765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6S06_RS04770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6S06_RS04780	COG0438	transferase activity, transferring glycosyl groups
B6S06_RS04785	COG2084	Dehydrogenase
B6S06_RS04790	COG4703	Protein of unknown function (DUF1797)
B6S06_RS04795	COG0322	excinuclease ABC activity
B6S06_RS04800	COG1846	Transcriptional regulator
B6S06_RS04805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6S06_RS04815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B6S06_RS04825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6S06_RS04835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6S06_RS04840	COG0439	Biotin carboxylase
B6S06_RS04845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B6S06_RS04850	COG0825	malonyl-CoA metabolic process
B6S06_RS04855	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B6S06_RS04860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B6S06_RS04865	COG1534	Rna-binding protein
B6S06_RS04870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B6S06_RS04875	COG1713	HD superfamily hydrolase involved in NAD metabolism
B6S06_RS04880	COG0799	negative regulation of ribosome biogenesis
B6S06_RS04885	COG2226	methyltransferase
B6S06_RS04890	COG1323	Belongs to the UPF0348 family
B6S06_RS04895	COG0217	transcriptional regulatory protein
B6S06_RS04905	COG3973	AAA domain
B6S06_RS04910	COG2217	Heavy metal translocating P-type atpase
B6S06_RS04915	COG1942	4-Oxalocrotonate Tautomerase
B6S06_RS04925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6S06_RS04930	COG1737	Transcriptional regulator
B6S06_RS04935	COG0768	penicillin binding
B6S06_RS04950	COG0561	phosphatase activity
B6S06_RS04955	COG2252	PERMEase
B6S06_RS04960	COG2814	Major facilitator Superfamily
B6S06_RS04970	COG0587	DNA-directed DNA polymerase activity
B6S06_RS04975	COG0205	6-phosphofructokinase activity
B6S06_RS04985	COG0583	DNA-binding transcription factor activity
B6S06_RS04995	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B6S06_RS05010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B6S06_RS05015	COG0745	RESPONSE REGULATOR receiver
B6S06_RS05020	COG5002	protein histidine kinase activity
B6S06_RS05125	COG3711	transcriptional antiterminator
B6S06_RS05135	COG1263	PTS System
B6S06_RS05135	COG2190	(PTS) system
B6S06_RS05135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS05140	COG1486	melibiose metabolic process
B6S06_RS05145	COG2190	(PTS) system
B6S06_RS05145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS05145	COG1263	PTS System
B6S06_RS05150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS05175	COG1349	DNA-binding transcription factor activity
B6S06_RS05200	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B6S06_RS05205	COG3623	hexulose-6-phosphate isomerase
B6S06_RS05215	COG0456	acetyltransferase
B6S06_RS05240	COG3711	transcriptional antiterminator
B6S06_RS05260	COG3775	system Galactitol-specific IIC component
B6S06_RS05275	COG0400	carboxylic ester hydrolase activity
B6S06_RS05280	COG0346	lactoylglutathione lyase activity
B6S06_RS05290	COG2188	Transcriptional regulator
B6S06_RS05295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS05300	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS05305	COG0589	response to stress
B6S06_RS05320	COG1393	Belongs to the ArsC family
B6S06_RS05330	COG0351	phosphomethylpyrimidine kinase
B6S06_RS05335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B6S06_RS05340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6S06_RS05350	COG3425	synthase
B6S06_RS05355	COG0183	Belongs to the thiolase family
B6S06_RS05380	COG0656	L-ascorbic acid biosynthetic process
B6S06_RS05400	COG0392	lysyltransferase activity
B6S06_RS05400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B6S06_RS05405	COG0596	Alpha beta hydrolase
B6S06_RS05410	COG0741	lytic transglycosylase activity
B6S06_RS05420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6S06_RS05425	COG0358	DNA primase activity
B6S06_RS05430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B6S06_RS05440	COG2996	Protein conserved in bacteria
B6S06_RS05445	COG0735	belongs to the Fur family
B6S06_RS05450	COG4974	Belongs to the 'phage' integrase family
B6S06_RS05460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B6S06_RS05465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6S06_RS05470	COG1187	pseudouridine synthase activity
B6S06_RS05475	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B6S06_RS05480	COG1288	antiporter activity
B6S06_RS05485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6S06_RS05505	COG0514	ATP-dependent DNA helicase (RecQ)
B6S06_RS05515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B6S06_RS05520	COG0539	negative regulation of cytoplasmic translation
B6S06_RS05525	COG1160	GTP binding
B6S06_RS05530	COG0776	regulation of translation
B6S06_RS05545	COG0457	Tetratricopeptide repeat
B6S06_RS05550	COG5582	Belongs to the UPF0302 family
B6S06_RS05555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6S06_RS05560	COG1694	Mazg nucleotide pyrophosphohydrolase
B6S06_RS05565	COG0617	tRNA 3'-terminal CCA addition
B6S06_RS05580	COG0025	NhaP-type Na H and K H
B6S06_RS05585	COG0488	(ABC) transporter
B6S06_RS05590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B6S06_RS05600	COG1272	protein, Hemolysin III
B6S06_RS05605	COG1307	EDD domain protein, DegV family
B6S06_RS05610	COG2755	lipolytic protein G-D-S-L family
B6S06_RS05615	COG4698	Protein conserved in bacteria
B6S06_RS05625	COG4479	Belongs to the UPF0346 family
B6S06_RS05630	COG0681	Belongs to the peptidase S26 family
B6S06_RS05645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B6S06_RS05650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B6S06_RS05655	COG0758	DNA mediated transformation
B6S06_RS05660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6S06_RS05665	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B6S06_RS05670	COG4974	Belongs to the 'phage' integrase family
B6S06_RS05675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B6S06_RS05680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B6S06_RS05695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B6S06_RS05700	COG1832	CoA-binding protein
B6S06_RS05705	COG0187	DNA topoisomerase II activity
B6S06_RS05715	COG1882	Formate acetyltransferase
B6S06_RS05720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B6S06_RS05725	COG1227	inorganic diphosphatase activity
B6S06_RS05745	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B6S06_RS05755	COG1073	alpha beta
B6S06_RS05760	COG1609	Transcriptional regulator
B6S06_RS05770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6S06_RS05790	COG1732	Glycine betaine
B6S06_RS05805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6S06_RS05815	COG1116	anion transmembrane transporter activity
B6S06_RS05820	COG0084	hydrolase, TatD family'
B6S06_RS05825	COG3942	CHAP domain
B6S06_RS05825	COG1388	LysM domain
B6S06_RS05855	COG0346	lactoylglutathione lyase activity
B6S06_RS05865	COG3328	transposase activity
B6S06_RS05880	COG0436	Aminotransferase
B6S06_RS05910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B6S06_RS05915	COG4565	transcriptional regulatory protein
B6S06_RS05920	COG3290	protein histidine kinase activity
B6S06_RS05925	COG3290	protein histidine kinase activity
B6S06_RS05935	COG2268	Band 7 protein
B6S06_RS05955	COG0673	inositol 2-dehydrogenase activity
B6S06_RS05965	COG1876	peptidase activity
B6S06_RS05970	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6S06_RS05970	COG1388	LysM domain
B6S06_RS05980	COG1653	transport
B6S06_RS05985	COG1175	transmembrane transport
B6S06_RS05990	COG0395	ABC-type sugar transport system, permease component
B6S06_RS06000	COG0673	inositol 2-dehydrogenase activity
B6S06_RS06005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6S06_RS06010	COG2233	PERMEase
B6S06_RS06020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B6S06_RS06025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B6S06_RS06030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6S06_RS06035	COG3344	reverse transcriptase
B6S06_RS06050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6S06_RS06055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6S06_RS06060	COG0047	phosphoribosylformylglycinamidine synthase activity
B6S06_RS06065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6S06_RS06075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6S06_RS06080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B6S06_RS06085	COG0138	bifunctional purine biosynthesis protein purh
B6S06_RS06090	COG0151	Belongs to the GarS family
B6S06_RS06095	COG4989	oxidoreductase activity
B6S06_RS06105	COG2972	Histidine kinase
B6S06_RS06115	COG4213	ABC transporter substrate-binding protein
B6S06_RS06125	COG4214	carbohydrate transport
B6S06_RS06130	COG0516	GMP reductase activity
B6S06_RS06140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6S06_RS06155	COG0022	dehydrogenase e1 component
B6S06_RS06170	COG4476	Belongs to the UPF0223 family
B6S06_RS06175	COG0483	inositol monophosphate 1-phosphatase activity
B6S06_RS06180	COG1217	gtp-binding protein TYPA
B6S06_RS06185	COG0514	ATP-dependent DNA helicase (RecQ)
B6S06_RS06190	COG4838	Belongs to the UPF0358 family
B6S06_RS06195	COG0772	Belongs to the SEDS family
B6S06_RS06200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B6S06_RS06215	COG4471	UPF0298 protein
B6S06_RS06220	COG0742	ribosomal rna small subunit methyltransferase
B6S06_RS06225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B6S06_RS06230	COG3480	Lon protease (S16) C-terminal proteolytic domain
B6S06_RS06235	COG1596	polysaccharide export
B6S06_RS06235	COG1555	photosystem II stabilization
B6S06_RS06250	COG2131	deaminase
B6S06_RS06255	COG0658	competence protein
B6S06_RS06255	COG2333	competence protein COMEC
B6S06_RS06260	COG1466	dna polymerase III delta subunit
B6S06_RS06265	COG0268	Binds directly to 16S ribosomal RNA
B6S06_RS06275	COG2707	UPF0756 membrane protein
B6S06_RS06280	COG2217	Heavy metal translocating P-type atpase
B6S06_RS06285	COG1968	undecaprenyl-diphosphatase activity
B6S06_RS06305	COG1666	GTP binding
B6S06_RS06310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6S06_RS06315	COG2151	metal-sulfur cluster biosynthetic enzyme
B6S06_RS06330	COG3942	CHAP domain
B6S06_RS06330	COG1388	LysM domain
B6S06_RS06385	COG4990	cell redox homeostasis
B6S06_RS06405	COG3104	oligopeptide transport
B6S06_RS06415	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B6S06_RS06420	COG1074	ATP-dependent DNA helicase activity
B6S06_RS06425	COG1733	regulation of RNA biosynthetic process
B6S06_RS06430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B6S06_RS06435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6S06_RS06435	COG0072	phenylalanine-tRNA ligase activity
B6S06_RS06445	COG1126	abc transporter atp-binding protein
B6S06_RS06450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6S06_RS06455	COG0765	amino acid transport
B6S06_RS06460	COG0765	amino acid transport
B6S06_RS06465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6S06_RS06470	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B6S06_RS06480	COG0517	IMP dehydrogenase activity
B6S06_RS06485	COG0668	transmembrane transport
B6S06_RS06495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B6S06_RS06500	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6S06_RS06505	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6S06_RS06535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B6S06_RS06545	COG1234	tRNA 3'-trailer cleavage
B6S06_RS06550	COG0300	oxidoreductase activity
B6S06_RS06555	COG5416	Lipopolysaccharide assembly protein A domain
B6S06_RS06560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B6S06_RS06560	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B6S06_RS06565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6S06_RS06575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6S06_RS06590	COG2826	transposase and inactivated derivatives, IS30 family
B6S06_RS06595	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6S06_RS06595	COG1388	LysM domain
B6S06_RS06600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6S06_RS06605	COG0735	belongs to the Fur family
B6S06_RS06610	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6S06_RS06625	COG1846	Transcriptional regulator
B6S06_RS06635	COG3935	DnaD domain protein
B6S06_RS06640	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B6S06_RS06650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6S06_RS06655	COG3331	DNA recombination
B6S06_RS06660	COG4474	Belongs to the UPF0398 family
B6S06_RS06665	COG3599	regulation of cell shape
B6S06_RS06675	COG0116	Belongs to the methyltransferase superfamily
B6S06_RS06680	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B6S06_RS06685	COG1418	mRNA catabolic process
B6S06_RS06705	COG0156	8-amino-7-oxononanoate synthase activity
B6S06_RS06710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6S06_RS06715	COG0531	amino acid
B6S06_RS06730	COG0513	Belongs to the DEAD box helicase family
B6S06_RS06735	COG2153	protein acetylation
B6S06_RS06745	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6S06_RS06750	COG4684	Psort location CytoplasmicMembrane, score
B6S06_RS06760	COG0328	RNA-DNA hybrid ribonuclease activity
B6S06_RS06770	COG1278	Cold shock
B6S06_RS06775	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B6S06_RS06790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B6S06_RS06795	COG0564	pseudouridine synthase activity
B6S06_RS06805	COG2233	PERMEase
B6S06_RS06810	COG0540	Belongs to the ATCase OTCase family
B6S06_RS06815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6S06_RS06820	COG0505	Belongs to the CarA family
B6S06_RS06825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6S06_RS06830	COG0543	2 iron, 2 sulfur cluster binding
B6S06_RS06840	COG0284	orotidine-5'-phosphate decarboxylase activity
B6S06_RS06870	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B6S06_RS06890	COG4120	Belongs to the binding-protein-dependent transport system permease family
B6S06_RS06900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B6S06_RS06935	COG0039	L-malate dehydrogenase activity
B6S06_RS06955	COG3037	sugar-specific permease SgaT UlaA
B6S06_RS06965	COG3711	transcriptional antiterminator
B6S06_RS07035	COG0745	RESPONSE REGULATOR receiver
B6S06_RS07040	COG5002	protein histidine kinase activity
B6S06_RS07045	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
B6S06_RS07055	COG0318	PFAM AMP-dependent synthetase and ligase
B6S06_RS07060	COG0351	phosphomethylpyrimidine kinase
B6S06_RS07070	COG4475	Protein of unknown function (DUF436)
B6S06_RS07075	COG0366	Alpha amylase catalytic
B6S06_RS07100	COG1307	EDD domain protein, DegV family
B6S06_RS07105	COG2244	polysaccharide biosynthetic process
B6S06_RS07160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B6S06_RS07165	COG0194	GDP metabolic process
B6S06_RS07185	COG0765	amino acid transport
B6S06_RS07190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6S06_RS07200	COG0167	dihydroorotate dehydrogenase activity
B6S06_RS07210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6S06_RS07220	COG3833	ABC-type maltose transport systems, permease component
B6S06_RS07225	COG1175	transmembrane transport
B6S06_RS07230	COG2182	Extracellular solute-binding protein
B6S06_RS07235	COG0366	Alpha amylase catalytic
B6S06_RS07240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6S06_RS07250	COG1764	response to oxidative stress
B6S06_RS07255	COG1846	Transcriptional regulator
B6S06_RS07260	COG0628	permease
B6S06_RS07275	COG1312	Catalyzes the dehydration of D-mannonate
B6S06_RS07280	COG0246	Mannitol dehydrogenase
B6S06_RS07290	COG0450	alkyl hydroperoxide reductase
B6S06_RS07340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B6S06_RS07355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B6S06_RS07370	COG0531	amino acid
B6S06_RS07375	COG0004	ammonium transporteR
B6S06_RS07385	COG2261	transglycosylase associated protein
B6S06_RS07420	COG3655	Transcriptional regulator
B6S06_RS07430	COG2261	transglycosylase associated protein
B6S06_RS07450	COG1028	Short-chain dehydrogenase reductase Sdr
B6S06_RS07465	COG1442	glycosyl transferase family 8
B6S06_RS07470	COG1442	glycosyl transferase family 8
B6S06_RS07475	COG0561	phosphatase activity
B6S06_RS07500	COG1476	TRANSCRIPTIONal
B6S06_RS07535	COG1278	Cold shock
B6S06_RS07540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6S06_RS07545	COG1312	Catalyzes the dehydration of D-mannonate
B6S06_RS07565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS07570	COG3716	PTS system mannose fructose sorbose family IID component
B6S06_RS07580	COG0371	Dehydrogenase
B6S06_RS07595	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B6S06_RS07600	COG1737	Transcriptional regulator
B6S06_RS07600	COG0837	glucose binding
B6S06_RS07610	COG2272	Belongs to the type-B carboxylesterase lipase family
B6S06_RS07615	COG1073	alpha beta
B6S06_RS07650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B6S06_RS07670	COG3732	PTS system glucitol sorbitol-specific
B6S06_RS07675	COG3730	PTS system glucitol sorbitol-specific
B6S06_RS07685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6S06_RS07685	COG3711	transcriptional antiterminator
B6S06_RS07725	COG3328	transposase activity
B6S06_RS07735	COG4974	Belongs to the 'phage' integrase family
B6S06_RS07740	COG0582	viral genome integration into host DNA
B6S06_RS07760	COG3250	beta-galactosidase activity
B6S06_RS07775	COG2211	Major facilitator Superfamily
B6S06_RS07785	COG1904	glucuronate isomerase
B6S06_RS07790	COG1312	Catalyzes the dehydration of D-mannonate
B6S06_RS07795	COG0246	Mannitol dehydrogenase
B6S06_RS07860	COG0433	COG0433 Predicted ATPase
B6S06_RS07905	COG2946	Replication initiation factor
B6S06_RS07915	COG1674	ftsk spoiiie
B6S06_RS07965	COG0481	GTPase activity
B6S06_RS07985	COG0542	response to heat
B6S06_RS08000	COG1597	lipid kinase activity
B6S06_RS08005	COG2195	Cleaves the N-terminal amino acid of tripeptides
B6S06_RS08010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B6S06_RS08015	COG2384	SAM-dependent methyltransferase
B6S06_RS08025	COG1484	DNA-dependent DNA replication
B6S06_RS08035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B6S06_RS08045	COG0237	dephospho-CoA kinase activity
B6S06_RS08050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B6S06_RS08055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6S06_RS08055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6S06_RS08070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B6S06_RS08075	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B6S06_RS08080	COG3091	SprT-like family
B6S06_RS08085	COG2183	response to ionizing radiation
B6S06_RS08095	COG1054	Belongs to the UPF0176 family
B6S06_RS08120	COG0546	phosphoglycolate phosphatase activity
B6S06_RS08125	COG0588	phosphoglycerate mutase activity
B6S06_RS08180	COG4753	response regulator
B6S06_RS08180	COG2207	Transcriptional regulator
B6S06_RS08190	COG2972	Histidine kinase
B6S06_RS08195	COG0077	Prephenate dehydratase
B6S06_RS08200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B6S06_RS08205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6S06_RS08210	COG0287	Prephenate dehydrogenase
B6S06_RS08215	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B6S06_RS08225	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B6S06_RS08235	COG3250	beta-galactosidase activity
B6S06_RS08250	COG1609	Transcriptional regulator
B6S06_RS08260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B6S06_RS08270	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6S06_RS08275	COG1597	lipid kinase activity
B6S06_RS08280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6S06_RS08285	COG0154	amidase activity
B6S06_RS08290	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6S06_RS08295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6S06_RS08300	COG0210	DNA helicase
B6S06_RS08315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6S06_RS08315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6S06_RS08315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6S06_RS08320	COG1105	Belongs to the carbohydrate kinase PfkB family
B6S06_RS08325	COG1349	DNA-binding transcription factor activity
B6S06_RS08340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B6S06_RS08345	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B6S06_RS08350	COG0544	peptidyl-prolyl cis-trans isomerase activity
B6S06_RS08360	COG1714	RDD family
B6S06_RS08375	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6S06_RS08380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6S06_RS08450	COG1481	regulation of sporulation
B6S06_RS08455	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B6S06_RS08460	COG1660	Displays ATPase and GTPase activities
B6S06_RS08475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6S06_RS08480	COG0556	nucleotide-excision repair
B6S06_RS08485	COG0765	amino acid transport
B6S06_RS08490	COG1126	abc transporter atp-binding protein
B6S06_RS08560	COG3835	regulator
B6S06_RS08565	COG0484	heat shock protein binding
B6S06_RS08570	COG0443	Heat shock 70 kDa protein
B6S06_RS08575	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B6S06_RS08580	COG1420	regulation of RNA biosynthetic process
B6S06_RS08595	COG0693	protein deglycase activity
B6S06_RS08615	COG1619	proteins homologs of microcin C7 resistance protein MccF
B6S06_RS08625	COG5646	InterPro IPR014922
B6S06_RS08635	COG4975	Glucose uptake
B6S06_RS08645	COG0196	riboflavin kinase activity
B6S06_RS08650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6S06_RS08660	COG1175	transmembrane transport
B6S06_RS08670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B6S06_RS08685	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B6S06_RS08690	COG0195	Participates in both transcription termination and antitermination
B6S06_RS08695	COG0779	Required for maturation of 30S ribosomal subunits
B6S06_RS08700	COG2176	DNA-directed DNA polymerase activity
B6S06_RS08705	COG0442	prolyl-tRNA aminoacylation
B6S06_RS08710	COG0750	zinc metalloprotease
B6S06_RS08715	COG4589	Belongs to the CDS family
B6S06_RS08720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6S06_RS08735	COG0233	cytoplasmic translational termination
B6S06_RS08740	COG0528	UMP kinase activity
B6S06_RS08745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B6S06_RS08750	COG0052	Belongs to the universal ribosomal protein uS2 family
B6S06_RS08755	COG1438	arginine binding
B6S06_RS08770	COG0018	arginyl-trna synthetase
B6S06_RS08785	COG2235	arginine
B6S06_RS08790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6S06_RS08795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6S06_RS08800	COG0456	acetyltransferase
B6S06_RS08810	COG1214	PFAM Peptidase M22, glycoprotease
B6S06_RS08815	COG1609	Transcriptional regulator
B6S06_RS08820	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B6S06_RS08825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B6S06_RS08840	COG3189	MarR family transcriptional regulator
B6S06_RS08845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B6S06_RS08850	COG1940	carbohydrate kinase activity
B6S06_RS08865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6S06_RS08870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6S06_RS08875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6S06_RS08880	COG1120	ATPase activity
B6S06_RS08895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6S06_RS08900	COG4876	unkown
B6S06_RS08905	COG0367	asparagine synthase
B6S06_RS08910	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B6S06_RS08925	COG1309	transcriptional regulator
B6S06_RS08945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6S06_RS08960	COG0584	glycerophosphoryl diester phosphodiesterase
B6S06_RS08985	COG0166	Belongs to the GPI family
B6S06_RS08990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B6S06_RS08995	COG2081	HI0933 family
B6S06_RS09000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B6S06_RS09005	COG0710	3-dehydroquinate dehydratase activity
B6S06_RS09010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B6S06_RS09015	COG1368	sulfuric ester hydrolase activity
B6S06_RS09040	COG3850	Histidine kinase
B6S06_RS09040	COG5002	protein histidine kinase activity
B6S06_RS09045	COG0745	RESPONSE REGULATOR receiver
B6S06_RS09095	COG3328	transposase activity
B6S06_RS09110	COG1956	GAF domain-containing protein
B6S06_RS09115	COG3527	Alpha-acetolactate decarboxylase
B6S06_RS09120	COG0028	Belongs to the TPP enzyme family
B6S06_RS09130	COG0395	ABC-type sugar transport system, permease component
B6S06_RS09140	COG0583	DNA-binding transcription factor activity
B6S06_RS09145	COG0789	Transcriptional regulator
B6S06_RS09150	COG2814	Major facilitator Superfamily
B6S06_RS09220	COG4974	Belongs to the 'phage' integrase family
B6S06_RS09245	COG4372	Transposase
B6S06_RS09280	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS09280	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6S06_RS09285	COG3716	PTS system mannose fructose sorbose family IID component
B6S06_RS09290	COG3715	PTS system
B6S06_RS09295	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B6S06_RS09295	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B6S06_RS09300	COG1940	carbohydrate kinase activity
B6S06_RS09305	COG2190	(PTS) system
B6S06_RS09320	COG1609	Transcriptional regulator
B6S06_RS09345	COG3385	transposase activity
B6S06_RS09365	COG0791	NLP P60 protein
B6S06_RS09365	COG0741	lytic transglycosylase activity
B6S06_RS09415	COG1196	nuclear chromosome segregation
B6S06_RS09440	COG2946	Replication initiation factor
B6S06_RS09455	COG1674	ftsk spoiiie
B6S06_RS09770	COG1396	sequence-specific DNA binding
B6S06_RS09790	COG0582	viral genome integration into host DNA
B6S06_RS09795	COG0335	large ribosomal subunit rRNA binding
B6S06_RS09800	COG0336	Belongs to the RNA methyltransferase TrmD family
B6S06_RS09805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B6S06_RS09815	COG1837	Belongs to the UPF0109 family
B6S06_RS09820	COG0228	four-way junction DNA binding
B6S06_RS09825	COG0431	NADPH-dependent FMN reductase
B6S06_RS09830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B6S06_RS09835	COG0519	Catalyzes the synthesis of GMP from XMP
B6S06_RS09840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6S06_RS09845	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B6S06_RS09855	COG0745	RESPONSE REGULATOR receiver
B6S06_RS09860	COG5002	protein histidine kinase activity
B6S06_RS09865	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B6S06_RS09870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B6S06_RS09890	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B6S06_RS09935	COG0714	Associated with various cellular activities
B6S06_RS09945	COG1305	Transglutaminase-like
B6S06_RS09950	COG2217	Heavy metal translocating P-type atpase
B6S06_RS09955	COG2217	Heavy metal translocating P-type atpase
B6S06_RS09960	COG2608	mercury ion transmembrane transporter activity
B6S06_RS09965	COG3682	Transcriptional regulator
B6S06_RS09980	COG0531	amino acid
B6S06_RS09985	COG2217	Heavy metal translocating P-type atpase
B6S06_RS10015	COG0017	Asparaginyl-tRNA synthetase
B6S06_RS10020	COG0436	Aminotransferase
B6S06_RS10030	COG1199	ATP-dependent helicase activity
B6S06_RS10030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6S06_RS10035	COG1278	Cold shock
B6S06_RS10060	COG1686	Belongs to the peptidase S11 family
B6S06_RS10070	COG0038	chloride channel
B6S06_RS10090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6S06_RS10095	COG1254	Belongs to the acylphosphatase family
B6S06_RS10105	COG0706	membrane insertase activity
B6S06_RS10110	COG3684	Belongs to the aldolase LacD family
B6S06_RS10170	COG1216	Glycosyl transferase, family 2
B6S06_RS10180	COG0438	transferase activity, transferring glycosyl groups
B6S06_RS10200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B6S06_RS10205	COG4464	protein tyrosine phosphatase activity
B6S06_RS10210	COG0489	protein tyrosine kinase activity
B6S06_RS10215	COG3944	biosynthesis protein
B6S06_RS10220	COG1316	TRANSCRIPTIONal
B6S06_RS10230	COG0751	glycine-tRNA ligase activity
B6S06_RS10235	COG0752	glycyl-tRNA synthetase alpha subunit
B6S06_RS10240	COG1381	Involved in DNA repair and RecF pathway recombination
B6S06_RS10245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B6S06_RS10250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B6S06_RS10255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B6S06_RS10265	COG1702	phosphate starvation-inducible protein PhoH
B6S06_RS10270	COG1114	Component of the transport system for branched-chain amino acids
B6S06_RS10285	COG1610	YqeY-like protein
B6S06_RS10290	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B6S06_RS10295	COG0735	belongs to the Fur family
B6S06_RS10300	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B6S06_RS10305	COG0640	Transcriptional regulator
B6S06_RS10310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6S06_RS10315	COG0492	ferredoxin-NADP+ reductase activity
B6S06_RS10320	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS10325	COG1486	melibiose metabolic process
B6S06_RS10335	COG1737	Transcriptional regulator
B6S06_RS10340	COG2190	(PTS) system
B6S06_RS10340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS10340	COG1263	PTS System
B6S06_RS10350	COG1132	(ABC) transporter
B6S06_RS10355	COG1132	(ABC) transporter
B6S06_RS10360	COG3763	UPF0154 protein
B6S06_RS10370	COG1914	H( )-stimulated, divalent metal cation uptake system
B6S06_RS10380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B6S06_RS10390	COG3328	transposase activity
B6S06_RS10425	COG1609	Transcriptional regulator
B6S06_RS10435	COG4980	gas vesicle protein
B6S06_RS10445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B6S06_RS10450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B6S06_RS10455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B6S06_RS10460	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B6S06_RS10465	COG1950	PFAM Membrane protein of
B6S06_RS10505	COG0704	Plays a role in the regulation of phosphate uptake
B6S06_RS10510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B6S06_RS10515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B6S06_RS10520	COG0581	inorganic phosphate transmembrane transporter activity
B6S06_RS10525	COG0573	inorganic phosphate transmembrane transporter activity
B6S06_RS10530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B6S06_RS10535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B6S06_RS10550	COG2177	Part of the ABC transporter FtsEX involved in
B6S06_RS10555	COG2884	Cell division ATP-binding protein ftsE
B6S06_RS10565	COG0653	protein targeting
B6S06_RS10580	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B6S06_RS10585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS10595	COG1739	Uncharacterized protein family UPF0029
B6S06_RS10600	COG2188	Transcriptional regulator
B6S06_RS10625	COG1940	carbohydrate kinase activity
B6S06_RS10645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B6S06_RS10655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B6S06_RS10660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B6S06_RS10665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B6S06_RS10670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B6S06_RS10675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6S06_RS10680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6S06_RS10685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6S06_RS10690	COG0356	it plays a direct role in the translocation of protons across the membrane
B6S06_RS10695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B6S06_RS10700	COG0557	exoribonuclease II activity
B6S06_RS10710	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B6S06_RS10715	COG2388	GCN5-related N-acetyl-transferase
B6S06_RS10735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6S06_RS10750	COG0149	triose-phosphate isomerase activity
B6S06_RS10755	COG0126	phosphoglycerate kinase activity
B6S06_RS10765	COG2390	Transcriptional regulator
B6S06_RS10770	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B6S06_RS10790	COG1595	DNA-templated transcription, initiation
B6S06_RS10810	COG0095	Lipoate-protein ligase
B6S06_RS10815	COG1078	dGTPase activity
B6S06_RS10820	COG0561	phosphatase activity
B6S06_RS10825	COG0494	nUDIX hydrolase
B6S06_RS10830	COG0346	lactoylglutathione lyase activity
B6S06_RS10840	COG2423	ornithine cyclodeaminase activity
B6S06_RS10845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6S06_RS10850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B6S06_RS10855	COG1394	ATPase activity, coupled to movement of substances
B6S06_RS10860	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
B6S06_RS10865	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
B6S06_RS10870	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
B6S06_RS10875	COG1527	subunit (C
B6S06_RS10880	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
B6S06_RS10885	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6S06_RS10890	COG1269	ATP hydrolysis coupled proton transport
B6S06_RS10900	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B6S06_RS10905	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
B6S06_RS10915	COG4152	abc transporter atp-binding protein
B6S06_RS10920	COG0322	excinuclease ABC activity
B6S06_RS10925	COG3118	belongs to the thioredoxin family
B6S06_RS10930	COG1193	negative regulation of DNA recombination
B6S06_RS10945	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B6S06_RS10960	COG1136	(ABC) transporter
B6S06_RS10970	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6S06_RS11005	COG1304	FMN binding
B6S06_RS11020	COG0281	malic enzyme
B6S06_RS11040	COG3906	Belongs to the UPF0473 family
B6S06_RS11045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B6S06_RS11050	COG4472	Bacterial protein of unknown function (DUF965)
B6S06_RS11080	COG4555	ABC transporter
B6S06_RS11090	COG3689	TIGRFAM TIGR03943 family protein
B6S06_RS11095	COG0701	Predicted permease
B6S06_RS11100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6S06_RS11105	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B6S06_RS11110	COG0488	(ABC) transporter
B6S06_RS11115	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B6S06_RS11130	COG0395	ABC-type sugar transport system, permease component
B6S06_RS11150	COG2207	Transcriptional regulator
B6S06_RS11150	COG0662	Cupin 2, conserved barrel domain protein
B6S06_RS11155	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6S06_RS11165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6S06_RS11170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B6S06_RS11175	COG0584	glycerophosphoryl diester phosphodiesterase
B6S06_RS11185	COG0740	serine-type endopeptidase activity
B6S06_RS11190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B6S06_RS11200	COG1132	(ABC) transporter
B6S06_RS11210	COG5503	Protein of unknown function (DUF1447)
B6S06_RS11225	COG1278	Cold shock
B6S06_RS11230	COG2003	Belongs to the UPF0758 family
B6S06_RS11235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6S06_RS11240	COG0285	dihydrofolate synthase activity
B6S06_RS11245	COG0525	valine-tRNA ligase activity
B6S06_RS11250	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B6S06_RS11255	COG0301	tRNA thio-modification
B6S06_RS11260	COG1104	cysteine desulfurase activity
B6S06_RS11265	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B6S06_RS11275	COG0561	phosphatase activity
B6S06_RS11280	COG1801	Protein of unknown function DUF72
B6S06_RS11300	COG3579	cysteine-type endopeptidase activity
B6S06_RS11365	COG1098	S1 RNA binding domain
B6S06_RS11370	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B6S06_RS11380	COG0492	ferredoxin-NADP+ reductase activity
B6S06_RS11385	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B6S06_RS11405	COG4470	Protein conserved in bacteria
B6S06_RS11410	COG0737	Belongs to the 5'-nucleotidase family
B6S06_RS11425	COG0590	tRNA wobble adenosine to inosine editing
B6S06_RS11430	COG2508	Transcriptional regulator
B6S06_RS11440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6S06_RS11440	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
B6S06_RS11460	COG2738	Putative neutral zinc metallopeptidase
B6S06_RS11465	COG2824	Alkylphosphonate utilization operon protein PhnA
B6S06_RS11470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B6S06_RS11475	COG4109	DRTGG domain
B6S06_RS11480	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6S06_RS11500	COG0577	efflux transmembrane transporter activity
B6S06_RS11505	COG1136	(ABC) transporter
B6S06_RS11515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B6S06_RS11520	COG1288	antiporter activity
B6S06_RS11525	COG4821	SIS domain
B6S06_RS11540	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B6S06_RS11545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B6S06_RS11550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6S06_RS11555	COG3716	PTS system mannose fructose sorbose family IID component
B6S06_RS11560	COG3715	PTS system
B6S06_RS11585	COG1132	(ABC) transporter
B6S06_RS11590	COG1132	(ABC) transporter
B6S06_RS11600	COG1803	Methylglyoxal synthase
B6S06_RS11605	COG3842	ATPase activity
B6S06_RS11615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6S06_RS11620	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B6S06_RS11625	COG0084	hydrolase, TatD family'
B6S06_RS11630	COG0531	amino acid
B6S06_RS11640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6S06_RS11640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6S06_RS11660	COG0675	Transposase, IS605 OrfB family
B6S06_RS11665	COG4608	Belongs to the ABC transporter superfamily
B6S06_RS11670	COG0444	Belongs to the ABC transporter superfamily
B6S06_RS11675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6S06_RS11680	COG0601	transmembrane transport
B6S06_RS11690	COG4166	transmembrane transport
B6S06_RS11715	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B6S06_RS11720	COG1674	ftsk spoiiie
B6S06_RS11720	COG1280	lysine exporter protein (LysE YggA)
B6S06_RS11725	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS11735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6S06_RS11740	COG1126	abc transporter atp-binding protein
B6S06_RS11745	COG0765	amino acid transport
B6S06_RS11790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B6S06_RS11800	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6S06_RS11805	COG0009	L-threonylcarbamoyladenylate synthase
B6S06_RS11815	COG2890	protein-(glutamine-N5) methyltransferase activity
B6S06_RS11820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6S06_RS11825	COG1435	thymidine kinase activity
B6S06_RS11835	COG2226	methyltransferase
B6S06_RS11840	COG0681	Belongs to the peptidase S26 family
B6S06_RS11860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B6S06_RS11865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B6S06_RS11870	COG3442	glutamine amidotransferase
B6S06_RS11885	COG0246	Mannitol dehydrogenase
B6S06_RS11890	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6S06_RS11895	COG2213	PTS system mannitol-specific
B6S06_RS11900	COG1131	(ABC) transporter
B6S06_RS11910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6S06_RS11915	COG3711	transcriptional antiterminator
B6S06_RS11920	COG2213	PTS system mannitol-specific
B6S06_RS11925	COG1482	cell wall glycoprotein biosynthetic process
B6S06_RS11945	COG1132	(ABC) transporter
B6S06_RS11965	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B6S06_RS11970	COG0628	permease
B6S06_RS11980	COG2706	6-phosphogluconolactonase activity
B6S06_RS11990	COG1368	sulfuric ester hydrolase activity
B6S06_RS12000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6S06_RS12005	COG2160	L-arabinose isomerase activity
B6S06_RS12010	COG0235	Class ii aldolase
B6S06_RS12030	COG3940	Belongs to the glycosyl hydrolase 43 family
B6S06_RS12035	COG3534	alpha-L-arabinofuranosidase
B6S06_RS12045	COG0395	ABC-type sugar transport system, permease component
B6S06_RS12050	COG1175	transmembrane transport
B6S06_RS12070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B6S06_RS12075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B6S06_RS12090	COG0789	Transcriptional regulator
B6S06_RS12095	COG1609	Transcriptional regulator
B6S06_RS12105	COG0459	protein refolding
B6S06_RS12110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B6S06_RS12120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS12125	COG2910	NAD(P)H-binding
B6S06_RS12130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B6S06_RS12145	COG5002	protein histidine kinase activity
B6S06_RS12150	COG0745	RESPONSE REGULATOR receiver
B6S06_RS12155	COG1307	EDD domain protein, DegV family
B6S06_RS12175	COG1714	RDD family
B6S06_RS12210	COG3279	Response regulator of the LytR AlgR family
B6S06_RS12250	COG3448	diguanylate cyclase activity
B6S06_RS12250	COG4175	Glycine betaine
B6S06_RS12280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B6S06_RS12285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6S06_RS12295	COG0628	permease
B6S06_RS12300	COG1285	pathogenesis
B6S06_RS12305	COG0363	glucosamine-6-phosphate deaminase activity
B6S06_RS12310	COG0488	(ABC) transporter
B6S06_RS12315	COG2814	Major facilitator Superfamily
B6S06_RS12325	COG0222	ribosome binding
B6S06_RS12330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B6S06_RS12335	COG0081	regulation of translation
B6S06_RS12340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B6S06_RS12345	COG1760	l-serine dehydratase
B6S06_RS12350	COG1760	l-serine dehydratase
B6S06_RS12355	COG1304	FMN binding
B6S06_RS12360	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B6S06_RS12365	COG0250	Participates in transcription elongation, termination and antitermination
B6S06_RS12370	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B6S06_RS12375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6S06_RS12390	COG1597	lipid kinase activity
B6S06_RS12410	COG4585	Histidine kinase
B6S06_RS12415	COG2197	response regulator
B6S06_RS12425	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B6S06_RS12435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B6S06_RS12440	COG2226	methyltransferase
B6S06_RS12445	COG3142	Participates in the control of copper homeostasis
B6S06_RS12450	COG2239	Acts as a magnesium transporter
B6S06_RS12455	COG0564	pseudouridine synthase activity
B6S06_RS12460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B6S06_RS12465	COG2357	RelA SpoT domain protein
B6S06_RS12490	COG4862	establishment of competence for transformation
B6S06_RS12500	COG1393	Belongs to the ArsC family
B6S06_RS12515	COG0419	ATPase involved in DNA repair
B6S06_RS12520	COG0420	3'-5' exonuclease activity
B6S06_RS12525	COG0204	Acyl-transferase
B6S06_RS12530	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B6S06_RS12535	COG2827	Endonuclease containing a URI domain
B6S06_RS12540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B6S06_RS12540	COG2755	lipolytic protein G-D-S-L family
B6S06_RS12545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B6S06_RS12550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B6S06_RS12555	COG0124	histidyl-tRNA synthetase
B6S06_RS12565	COG0667	Aldo Keto reductase
B6S06_RS12570	COG2124	cytochrome p450
B6S06_RS12575	COG1490	D-aminoacyl-tRNA deacylase activity
B6S06_RS12580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6S06_RS12590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B6S06_RS12595	COG2264	protein methyltransferase activity
B6S06_RS12605	COG2094	Belongs to the DNA glycosylase MPG family
B6S06_RS12610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6S06_RS12625	COG0589	response to stress
B6S06_RS12635	COG0488	(ABC) transporter
B6S06_RS12640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B6S06_RS12645	COG0827	DNA restriction-modification system
B6S06_RS12670	COG4537	Required for transformation and DNA binding
B6S06_RS12675	COG1459	type II secretion system
B6S06_RS12680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B6S06_RS12685	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B6S06_RS12690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B6S06_RS12700	COG4473	ABC transporter
B6S06_RS12705	COG1131	(ABC) transporter
B6S06_RS12710	COG0537	adenosine 5'-monophosphoramidase activity
B6S06_RS12720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B6S06_RS12725	COG3481	metal-dependent phosphohydrolase, HD sub domain
B6S06_RS12730	COG4717	serine-type aminopeptidase activity
B6S06_RS12735	COG0420	3'-5' exonuclease activity
B6S06_RS12745	COG0561	phosphatase activity
B6S06_RS12780	COG2211	Major facilitator Superfamily
B6S06_RS12790	COG3507	Belongs to the glycosyl hydrolase 43 family
B6S06_RS12805	COG1073	alpha beta
B6S06_RS12815	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B6S06_RS12820	COG1653	transport
B6S06_RS12830	COG4209	transmembrane transport
B6S06_RS12835	COG0395	ABC-type sugar transport system, permease component
B6S06_RS12845	COG2207	Transcriptional regulator
B6S06_RS12850	COG1609	Transcriptional regulator
B6S06_RS12855	COG0246	Mannitol dehydrogenase
B6S06_RS12860	COG2721	sulfolactate sulfo-lyase activity
B6S06_RS12865	COG1904	glucuronate isomerase
B6S06_RS12870	COG2755	lipolytic protein G-D-S-L family
B6S06_RS12880	COG1132	(ABC) transporter
B6S06_RS12885	COG3679	Belongs to the UPF0342 family
B6S06_RS12890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6S06_RS12895	COG0564	pseudouridine synthase activity
B6S06_RS12910	COG0383	alpha-mannosidase activity
B6S06_RS12935	COG4753	response regulator
B6S06_RS12935	COG2207	Transcriptional regulator
B6S06_RS12940	COG2972	Histidine kinase
B6S06_RS12955	COG1653	transport
B6S06_RS12960	COG0395	ABC-type sugar transport system, permease component
B6S06_RS12965	COG1175	transmembrane transport
B6S06_RS12975	COG1187	pseudouridine synthase activity
B6S06_RS12980	COG2244	polysaccharide biosynthetic process
B6S06_RS12990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6S06_RS12995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS13010	COG3711	transcriptional antiterminator
B6S06_RS13010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6S06_RS13065	COG0789	Transcriptional regulator
B6S06_RS13065	COG4978	Transcriptional regulator
B6S06_RS13075	COG1132	(ABC) transporter
B6S06_RS13090	COG0495	leucyl-tRNA aminoacylation
B6S06_RS13095	COG1388	LysM domain
B6S06_RS13095	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6S06_RS13100	COG0671	phosphoesterase, PA-phosphatase related
B6S06_RS13105	COG1242	4 iron, 4 sulfur cluster binding
B6S06_RS13110	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B6S06_RS13285	COG1783	phage Terminase large subunit
B6S06_RS13335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B6S06_RS13345	COG3723	Recombinational DNA repair protein, rece pathway
B6S06_RS13350	COG5377	YqaJ viral recombinase family
B6S06_RS13385	COG1396	sequence-specific DNA binding
B6S06_RS13400	COG0582	viral genome integration into host DNA
B6S06_RS13405	COG1132	(ABC) transporter
B6S06_RS13410	COG1132	(ABC) transporter
B6S06_RS13425	COG0477	Major facilitator Superfamily
B6S06_RS13430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B6S06_RS13585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B6S06_RS13590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6S06_RS13595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B6S06_RS13605	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B6S06_RS13610	COG0037	tRNA processing
B6S06_RS13615	COG1098	S1 RNA binding domain
B6S06_RS13625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B6S06_RS13630	COG2244	polysaccharide biosynthetic process
B6S06_RS13635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B6S06_RS13640	COG0193	aminoacyl-tRNA hydrolase activity
B6S06_RS13645	COG0039	L-malate dehydrogenase activity
B6S06_RS13655	COG0217	transcriptional regulatory protein
B6S06_RS13680	COG1792	Involved in formation and maintenance of cell shape
B6S06_RS13690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B6S06_RS13695	COG1162	GTPase activity
B6S06_RS13700	COG2815	serine threonine protein kinase
B6S06_RS13700	COG0515	serine threonine protein kinase
B6S06_RS13705	COG0631	protein serine/threonine phosphatase activity
B6S06_RS13710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6S06_RS13710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6S06_RS13715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6S06_RS13720	COG0242	peptide deformylase activity
B6S06_RS13725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B6S06_RS13730	COG1758	RNA polymerase activity
B6S06_RS13735	COG0194	GDP metabolic process
B6S06_RS13745	COG1561	YicC-like family, N-terminal region
B6S06_RS13755	COG1752	Esterase of the alpha-beta hydrolase superfamily
B6S06_RS13770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B6S06_RS13775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6S06_RS13780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B6S06_RS13785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6S06_RS13790	COG1121	(ABC) transporter
B6S06_RS13795	COG0803	Belongs to the bacterial solute-binding protein 9 family
B6S06_RS13795	COG3443	Belongs to the bacterial solute-binding protein 9 family
B6S06_RS13800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B6S06_RS13805	COG0392	lysyltransferase activity
B6S06_RS13805	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B6S06_RS13810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B6S06_RS13815	COG1418	mRNA catabolic process
B6S06_RS13820	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B6S06_RS13825	COG1058	Belongs to the CinA family
B6S06_RS13825	COG1546	Belongs to the CinA family
B6S06_RS13830	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6S06_RS13840	COG1426	Protein conserved in bacteria
B6S06_RS13845	COG0612	Peptidase, M16
B6S06_RS13850	COG0612	Peptidase, M16
B6S06_RS13855	COG1970	mechanosensitive ion channel activity
B6S06_RS13860	COG2153	protein acetylation
B6S06_RS13865	COG4466	Protein conserved in bacteria
B6S06_RS13875	COG3688	RNA-binding protein containing a PIN domain
B6S06_RS13880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6S06_RS13885	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B6S06_RS13890	COG0215	cysteine-tRNA ligase activity
B6S06_RS13895	COG1045	serine acetyltransferase
B6S06_RS13900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6S06_RS13905	COG4956	integral membrane protein (PIN domain superfamily)
B6S06_RS13915	COG0756	dUTP diphosphatase activity
B6S06_RS13920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B6S06_RS13925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B6S06_RS13945	COG2814	Major facilitator Superfamily
B6S06_RS13975	COG0778	Nitroreductase
B6S06_RS13985	COG1388	LysM domain
B6S06_RS13985	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6S06_RS13990	COG4221	oxidoreductase activity
B6S06_RS14000	COG0583	DNA-binding transcription factor activity
B6S06_RS14005	COG3711	transcriptional antiterminator
B6S06_RS14010	COG2190	(PTS) system
B6S06_RS14010	COG1263	PTS System
B6S06_RS14010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS14015	COG0702	epimerase
B6S06_RS14030	COG2207	Transcriptional regulator
B6S06_RS14030	COG3708	Transcriptional regulator
B6S06_RS14050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B6S06_RS14060	COG2723	6-phospho-beta-galactosidase activity
B6S06_RS14065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B6S06_RS14075	COG0604	alcohol dehydrogenase
B6S06_RS14085	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6S06_RS14095	COG0842	Transport permease protein
B6S06_RS14100	COG1131	(ABC) transporter
B6S06_RS14110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B6S06_RS14115	COG0383	alpha-mannosidase activity
B6S06_RS14120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6S06_RS14125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6S06_RS14130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6S06_RS14130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B6S06_RS14130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6S06_RS14135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6S06_RS14135	COG3711	transcriptional antiterminator
B6S06_RS14140	COG2205	protein histidine kinase activity
B6S06_RS14145	COG0745	RESPONSE REGULATOR receiver
B6S06_RS14185	COG1674	ftsk spoiiie
B6S06_RS14210	COG2946	Replication initiation factor
B6S06_RS14250	COG0791	NLP P60 protein
B6S06_RS14250	COG0741	lytic transglycosylase activity
B6S06_RS14275	COG2814	Major facilitator Superfamily
B6S06_RS14285	COG3942	CHAP domain
B6S06_RS14285	COG1705	Flagellar rod assembly protein muramidase FlgJ
B6S06_RS14290	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6S06_RS14305	COG2207	Transcriptional regulator
B6S06_RS14305	COG3708	Transcriptional regulator
B6S06_RS14345	COG0523	cobalamin synthesis protein
B6S06_RS14365	COG3443	Belongs to the bacterial solute-binding protein 9 family
B6S06_RS14365	COG0803	Belongs to the bacterial solute-binding protein 9 family
B6S06_RS14380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B6S06_RS14390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B6S06_RS14395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6S06_RS14400	COG1132	(ABC) transporter
B6S06_RS14405	COG1132	(ABC) transporter
B6S06_RS14415	COG1129	ABC transporter
B6S06_RS14425	COG1309	transcriptional regulator
B6S06_RS14460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6S06_RS14465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B6S06_RS14470	COG0783	Belongs to the Dps family
B6S06_RS14475	COG1070	Carbohydrate kinase
B6S06_RS14480	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B6S06_RS14485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6S06_RS14490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6S06_RS14500	COG1554	hydrolase, family 65, central catalytic
B6S06_RS14505	COG0673	inositol 2-dehydrogenase activity
B6S06_RS14510	COG1082	Xylose isomerase domain protein TIM barrel
B6S06_RS14515	COG1063	alcohol dehydrogenase
B6S06_RS14520	COG0395	ABC-type sugar transport system, permease component
B6S06_RS14525	COG1175	transmembrane transport
B6S06_RS14530	COG1653	transport
B6S06_RS14535	COG0366	Alpha amylase catalytic
B6S06_RS14540	COG1609	Transcriptional regulator
B6S06_RS14545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6S06_RS14550	COG0085	RNA polymerase activity
B6S06_RS14565	COG4120	Belongs to the binding-protein-dependent transport system permease family
B6S06_RS14580	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B6S06_RS14580	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B6S06_RS14595	COG0142	geranyltranstransferase activity
B6S06_RS14615	COG4939	FMN-binding domain protein
B6S06_RS14635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6S06_RS14640	COG0826	peptidase U32
B6S06_RS14645	COG0826	peptidase U32
B6S06_RS14650	COG0542	response to heat
B6S06_RS14655	COG4463	regulation of RNA biosynthetic process
B6S06_RS14735	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6S06_RS14745	COG0517	IMP dehydrogenase activity
B6S06_RS14745	COG0516	GMP reductase activity
B6S06_RS14760	COG0012	GTP binding
B6S06_RS14765	COG4481	Protein conserved in bacteria
B6S06_RS14770	COG1475	DNA binding
B6S06_RS14775	COG1192	Involved in chromosome partitioning
B6S06_RS14780	COG0357	Ribosomal RNA small subunit methyltransferase G
B6S06_RS14785	COG0445	tRNA wobble uridine modification
B6S06_RS14790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B6S06_RS14800	COG1847	R3H domain protein
B6S06_RS14805	COG0706	membrane insertase activity
B6S06_RS14810	COG0594	ribonuclease P activity
B6S06_RS14815	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B6S06_RS14845	COG3328	transposase activity
B6S06_RS14850	COG0582	viral genome integration into host DNA
B6S06_RS14860	COG0346	lactoylglutathione lyase activity
B6S06_RS14870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B6S06_RS14875	COG1609	Transcriptional regulator
B6S06_RS14890	COG0395	ABC-type sugar transport system, permease component
B6S06_RS14895	COG1486	melibiose metabolic process
B6S06_RS14900	COG1653	transport
B6S06_RS14905	COG1175	transmembrane transport
B6S06_RS14910	COG0395	ABC-type sugar transport system, permease component
B6S06_RS14920	COG0366	Alpha amylase catalytic
B6S06_RS14925	COG0366	Alpha amylase catalytic
B6S06_RS14950	COG4974	Belongs to the 'phage' integrase family
B6S06_RS14995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS14995	COG1263	PTS System
B6S06_RS14995	COG2190	(PTS) system
B6S06_RS15000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS15000	COG1263	PTS System
B6S06_RS15000	COG2190	(PTS) system
B6S06_RS15005	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
B6S06_RS15050	COG1609	Transcriptional regulator
B6S06_RS15055	COG1621	beta-fructofuranosidase activity
B6S06_RS15060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B6S06_RS15060	COG2190	(PTS) system
B6S06_RS15060	COG1263	PTS System
B6S06_RS15065	COG1940	carbohydrate kinase activity
B6S06_RS15090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6S06_RS15105	COG3409	Peptidoglycan-binding domain 1 protein
B6S06_RS15130	COG5002	protein histidine kinase activity
B6S06_RS15150	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6S06_RS15165	COG3842	ATPase activity
B6S06_RS15175	COG0395	ABC-type sugar transport system, permease component
B6S06_RS15190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B6S06_RS15215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B6S06_RS15230	COG1136	(ABC) transporter
B6S06_RS15250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6S06_RS15500	COG3344	reverse transcriptase
B6S06_RS15580	COG0629	single-stranded DNA binding
B6S06_RS15660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6S06_RS15665	COG2188	Transcriptional regulator
B6S06_RS15685	COG3715	PTS system
B6S06_RS15690	COG3716	PTS system mannose fructose sorbose family IID component
B6S06_RS15715	COG3328	transposase activity
B6S06_RS15760	COG3715	PTS system
B6S06_RS15765	COG3716	PTS system mannose fructose sorbose family IID component
B6S06_RS15770	COG2222	sugar isomerase
B6S06_RS15775	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B6S06_RS15775	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B6S06_RS15780	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6S06_RS15805	COG4372	Transposase
B6S06_RS15825	COG2222	sugar isomerase
B6S06_RS15830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6S06_RS15835	COG2188	Transcriptional regulator
B6S06_RS15855	COG1288	antiporter activity
B6S06_RS15875	COG1053	succinate dehydrogenase
B6S06_RS15875	COG3976	FMN-binding domain protein
B6S06_RS15875	COG0431	NADPH-dependent FMN reductase
B6S06_RS15905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6S06_RS15955	COG1609	Transcriptional regulator
B6S06_RS15965	COG1175	transmembrane transport
B6S06_RS15970	COG0395	ABC-type sugar transport system, permease component
B6S06_RS15980	COG1940	carbohydrate kinase activity
B6S06_RS16070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6S06_RS16190	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B6S06_RS16250	COG1192	Involved in chromosome partitioning
B6S06_RS16295	COG2226	methyltransferase
B6S06_RS16335	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B6S06_RS16350	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs