locus-tag	class	description
I7089_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I7089_RS00010	COG0592	DNA-directed DNA polymerase activity
I7089_RS00015	COG2501	S4 domain
I7089_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I7089_RS00025	COG0187	DNA topoisomerase II activity
I7089_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
I7089_RS00040	COG0629	single-stranded DNA binding
I7089_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I7089_RS00055	COG0359	binds to the 23S rRNA
I7089_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
I7089_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I7089_RS00075	COG0488	(ABC) transporter
I7089_RS00085	COG0028	Belongs to the TPP enzyme family
I7089_RS00130	COG3328	transposase activity
I7089_RS00160	COG2723	6-phospho-beta-galactosidase activity
I7089_RS00170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS00170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS00180	COG3328	transposase activity
I7089_RS00210	COG1674	ftsk spoiiie
I7089_RS00215	COG2946	Replication initiation factor
I7089_RS00260	COG0791	NLP P60 protein
I7089_RS00260	COG0741	lytic transglycosylase activity
I7089_RS00305	COG0582	viral genome integration into host DNA
I7089_RS00310	COG0519	Catalyzes the synthesis of GMP from XMP
I7089_RS00310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I7089_RS00315	COG1072	(Pantothenic acid kinase))
I7089_RS00320	COG2813	Specifically methylates the guanine in position
I7089_RS00325	COG1609	Transcriptional regulator
I7089_RS00330	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I7089_RS00335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I7089_RS00340	COG0295	cytidine deaminase activity
I7089_RS00345	COG1744	ABC transporter substrate-binding protein PnrA-like
I7089_RS00350	COG3845	ABC transporter
I7089_RS00355	COG4603	Belongs to the binding-protein-dependent transport system permease family
I7089_RS00360	COG1079	Belongs to the binding-protein-dependent transport system permease family
I7089_RS00365	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I7089_RS00375	COG0813	purine-nucleoside phosphorylase activity
I7089_RS00380	COG0588	phosphoglycerate mutase activity
I7089_RS00390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I7089_RS00395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I7089_RS00400	COG0049	tRNA binding
I7089_RS00405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I7089_RS00410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I7089_RS00415	COG0051	transcription antitermination factor activity, RNA binding
I7089_RS00420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I7089_RS00425	COG0088	Forms part of the polypeptide exit tunnel
I7089_RS00430	COG0089	rRNA binding
I7089_RS00435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I7089_RS00445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I7089_RS00450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I7089_RS00455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I7089_RS00460	COG0255	Belongs to the universal ribosomal protein uL29 family
I7089_RS00465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I7089_RS00470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I7089_RS00475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I7089_RS00480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I7089_RS00485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I7089_RS00490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I7089_RS00495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I7089_RS00500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I7089_RS00505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I7089_RS00510	COG1841	ribosomal large subunit assembly
I7089_RS00515	COG0200	Binds to the 23S rRNA
I7089_RS00520	COG0201	protein transport
I7089_RS00525	COG0563	adenylate kinase activity
I7089_RS00530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I7089_RS00535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I7089_RS00540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I7089_RS00545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I7089_RS00550	COG0202	RNA polymerase activity
I7089_RS00555	COG0203	ribosomal protein L17
I7089_RS00560	COG1122	ATPase activity
I7089_RS00565	COG1122	ATPase activity
I7089_RS00575	COG0101	tRNA pseudouridine synthase activity
I7089_RS00585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I7089_RS00595	COG1461	Dihydroxyacetone kinase
I7089_RS00600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I7089_RS00605	COG0416	fatty acid biosynthetic process
I7089_RS00610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I7089_RS00620	COG4608	Belongs to the ABC transporter superfamily
I7089_RS00625	COG0601	transmembrane transport
I7089_RS00640	COG0571	ribonuclease III activity
I7089_RS00645	COG1196	nuclear chromosome segregation
I7089_RS00650	COG0561	phosphatase activity
I7089_RS00655	COG0552	protein localization to endoplasmic reticulum
I7089_RS00660	COG2918	glutathione biosynthetic process
I7089_RS00660	COG1181	Belongs to the D-alanine--D-alanine ligase family
I7089_RS00670	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7089_RS00675	COG4605	iron ion homeostasis
I7089_RS00680	COG4604	ABC transporter, ATP-binding protein
I7089_RS00685	COG4607	ABC-type enterochelin transport system periplasmic component
I7089_RS00710	COG4886	Leucine-rich repeat (LRR) protein
I7089_RS00710	COG4932	domain protein
I7089_RS00725	COG3328	transposase activity
I7089_RS00745	COG1380	Effector of murein hydrolase LrgA
I7089_RS00750	COG1346	cytolysis
I7089_RS00775	COG1028	Short-chain dehydrogenase reductase Sdr
I7089_RS00785	COG1268	BioY protein
I7089_RS00790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I7089_RS00805	COG0561	phosphatase activity
I7089_RS00810	COG1692	metallophosphoesterase
I7089_RS00820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I7089_RS00830	COG0424	maF-like protein
I7089_RS00835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS00835	COG1263	PTS System
I7089_RS00840	COG2188	Transcriptional regulator
I7089_RS00850	COG0632	four-way junction helicase activity
I7089_RS00855	COG2255	four-way junction helicase activity
I7089_RS00865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I7089_RS00875	COG3328	transposase activity
I7089_RS00880	COG1114	Component of the transport system for branched-chain amino acids
I7089_RS00890	COG1113	amino acid transport
I7089_RS00895	COG1126	abc transporter atp-binding protein
I7089_RS00900	COG0765	amino acid transport
I7089_RS00910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I7089_RS00915	COG0110	maltose O-acetyltransferase activity
I7089_RS00920	COG1827	regulation of RNA biosynthetic process
I7089_RS00925	COG0242	peptide deformylase activity
I7089_RS00930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I7089_RS00935	COG1185	polyribonucleotide nucleotidyltransferase activity
I7089_RS00945	COG3158	transport of potassium into the cell
I7089_RS00950	COG1253	flavin adenine dinucleotide binding
I7089_RS00955	COG0534	Mate efflux family protein
I7089_RS00965	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I7089_RS00970	COG1187	pseudouridine synthase activity
I7089_RS00975	COG1011	Hydrolase
I7089_RS00980	COG0572	uridine kinase
I7089_RS01005	COG1671	Belongs to the UPF0178 family
I7089_RS01015	COG1181	Belongs to the D-alanine--D-alanine ligase family
I7089_RS01020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I7089_RS01030	COG0736	holo-[acyl-carrier-protein] synthase activity
I7089_RS01035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I7089_RS01040	COG2337	Toxic component of a toxin-antitoxin (TA) module
I7089_RS01045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I7089_RS01050	COG0604	alcohol dehydrogenase
I7089_RS01050	COG3321	synthase
I7089_RS01060	COG0531	amino acid
I7089_RS01085	COG1174	glycine betaine transport
I7089_RS01105	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I7089_RS01125	COG0343	queuine tRNA-ribosyltransferase activity
I7089_RS01130	COG1862	Preprotein translocase
I7089_RS01135	COG1012	belongs to the aldehyde dehydrogenase family
I7089_RS01135	COG1454	alcohol dehydrogenase
I7089_RS01145	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I7089_RS01175	COG2207	Transcriptional regulator
I7089_RS01175	COG1917	Cupin 2, conserved barrel domain protein
I7089_RS01180	COG1070	Carbohydrate kinase
I7089_RS01185	COG4806	L-rhamnose isomerase
I7089_RS01190	COG0235	Class ii aldolase
I7089_RS01195	COG3254	rhamnose metabolic process
I7089_RS01200	COG1454	alcohol dehydrogenase
I7089_RS01205	COG1414	Transcriptional regulator
I7089_RS01210	COG0800	Aldolase
I7089_RS01220	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I7089_RS01225	COG1028	Short-chain dehydrogenase reductase Sdr
I7089_RS01230	COG1304	FMN binding
I7089_RS01245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I7089_RS01250	COG1428	Deoxynucleoside kinase
I7089_RS01270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I7089_RS01275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I7089_RS01280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I7089_RS01310	COG0824	Thioesterase
I7089_RS01315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I7089_RS01335	COG1363	Peptidase, m42
I7089_RS01340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7089_RS01345	COG0589	response to stress
I7089_RS01350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7089_RS01355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I7089_RS01360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I7089_RS01365	COG4807	Protein conserved in bacteria
I7089_RS01375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I7089_RS01390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I7089_RS01455	COG1368	sulfuric ester hydrolase activity
I7089_RS01465	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I7089_RS01475	COG0101	tRNA pseudouridine synthase activity
I7089_RS01490	COG3328	transposase activity
I7089_RS01510	COG0667	Aldo Keto reductase
I7089_RS01515	COG2186	Transcriptional regulator
I7089_RS01520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS01525	COG2723	6-phospho-beta-galactosidase activity
I7089_RS01535	COG1447	Phosphotransferase system cellobiose-specific component IIA
I7089_RS01555	COG1063	alcohol dehydrogenase
I7089_RS01565	COG4716	Myosin-crossreactive antigen
I7089_RS01605	COG1113	amino acid transport
I7089_RS01630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I7089_RS01640	COG3052	prosthetic group binding
I7089_RS01700	COG1051	belongs to the nudix hydrolase family
I7089_RS01705	COG1846	Transcriptional regulator
I7089_RS01730	COG2252	PERMEase
I7089_RS01735	COG0366	Alpha amylase catalytic
I7089_RS01740	COG2723	6-phospho-beta-galactosidase activity
I7089_RS01750	COG1263	PTS System
I7089_RS01750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS01750	COG2190	(PTS) system
I7089_RS01755	COG2723	6-phospho-beta-galactosidase activity
I7089_RS01765	COG1902	pentaerythritol trinitrate reductase activity
I7089_RS01775	COG0446	pyridine nucleotide-disulphide oxidoreductase
I7089_RS01785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I7089_RS01790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I7089_RS01795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I7089_RS01805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I7089_RS01815	COG1937	Protein conserved in bacteria
I7089_RS01820	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I7089_RS01825	COG0446	pyridine nucleotide-disulphide oxidoreductase
I7089_RS01830	COG3973	AAA domain
I7089_RS01855	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I7089_RS01860	COG2376	Dihydroxyacetone kinase
I7089_RS01865	COG1461	Dihydroxyacetone kinase
I7089_RS01875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I7089_RS01885	COG1131	(ABC) transporter
I7089_RS01890	COG1309	transcriptional regulator
I7089_RS01910	COG0531	amino acid
I7089_RS01920	COG1609	Transcriptional regulator
I7089_RS01930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7089_RS01940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS01940	COG1263	PTS System
I7089_RS01940	COG2190	(PTS) system
I7089_RS01965	COG3479	Phenolic acid decarboxylase
I7089_RS01970	COG1695	Transcriptional regulator
I7089_RS01980	COG2814	Major facilitator Superfamily
I7089_RS02000	COG0163	prenyltransferase activity
I7089_RS02005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I7089_RS02015	COG0577	efflux transmembrane transporter activity
I7089_RS02015	COG1136	(ABC) transporter
I7089_RS02035	COG1811	Na channel or pump
I7089_RS02070	COG1136	(ABC) transporter
I7089_RS02085	COG1705	Flagellar rod assembly protein muramidase FlgJ
I7089_RS02085	COG3942	CHAP domain
I7089_RS02090	COG1263	PTS System
I7089_RS02090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS02090	COG2190	(PTS) system
I7089_RS02095	COG1869	D-ribose catabolic process
I7089_RS02105	COG1609	Transcriptional regulator
I7089_RS02125	COG0366	Alpha amylase catalytic
I7089_RS02130	COG0628	permease
I7089_RS02135	COG3443	Belongs to the bacterial solute-binding protein 9 family
I7089_RS02135	COG0803	Belongs to the bacterial solute-binding protein 9 family
I7089_RS02160	COG1428	Deoxynucleoside kinase
I7089_RS02170	COG0210	DNA helicase
I7089_RS02180	COG1393	Belongs to the ArsC family
I7089_RS02185	COG1393	Belongs to the ArsC family
I7089_RS02190	COG2801	Transposase and inactivated derivatives
I7089_RS02195	COG2963	transposase activity
I7089_RS02215	COG0386	Belongs to the glutathione peroxidase family
I7089_RS02220	COG1854	S-ribosylhomocysteine lyase activity
I7089_RS02225	COG0626	cystathionine gamma-synthase activity
I7089_RS02235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I7089_RS02240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I7089_RS02250	COG0019	diaminopimelate decarboxylase activity
I7089_RS02255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I7089_RS02265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I7089_RS02270	COG2171	N-acyltransferase activity
I7089_RS02275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I7089_RS02280	COG0527	aspartate kinase activity
I7089_RS02285	COG1473	amidohydrolase
I7089_RS02290	COG0436	Aminotransferase
I7089_RS02295	COG0446	pyridine nucleotide-disulphide oxidoreductase
I7089_RS02315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I7089_RS02320	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I7089_RS02335	COG2207	Transcriptional regulator
I7089_RS02340	COG2249	NAD(P)H dehydrogenase (quinone) activity
I7089_RS02355	COG1113	amino acid transport
I7089_RS02360	COG1121	(ABC) transporter
I7089_RS02365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I7089_RS02380	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I7089_RS02385	COG1652	LysM domain
I7089_RS02385	COG2823	Periplasmic or secreted lipoprotein
I7089_RS02395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I7089_RS02400	COG0477	Major facilitator Superfamily
I7089_RS02410	COG1438	arginine binding
I7089_RS02425	COG1764	response to oxidative stress
I7089_RS02430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I7089_RS02435	COG1335	isochorismatase
I7089_RS02450	COG2135	peptidase activity
I7089_RS02485	COG3546	catalase activity
I7089_RS02495	COG1175	transmembrane transport
I7089_RS02500	COG0395	ABC-type sugar transport system, permease component
I7089_RS02540	COG0745	RESPONSE REGULATOR receiver
I7089_RS02545	COG2205	protein histidine kinase activity
I7089_RS02550	COG4975	Glucose uptake
I7089_RS02555	COG0531	amino acid
I7089_RS02560	COG3853	Toxic anion resistance protein (TelA)
I7089_RS02580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I7089_RS02585	COG1335	isochorismatase
I7089_RS02595	COG3590	peptidase
I7089_RS02605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I7089_RS02610	COG1104	cysteine desulfurase activity
I7089_RS02630	COG0482	sulfurtransferase activity
I7089_RS02640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I7089_RS02645	COG2814	Major facilitator Superfamily
I7089_RS02665	COG0463	Glycosyl transferase, family 2
I7089_RS02670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I7089_RS02675	COG2855	membrane
I7089_RS02685	COG0583	DNA-binding transcription factor activity
I7089_RS02690	COG0772	Belongs to the SEDS family
I7089_RS02695	COG1393	Belongs to the ArsC family
I7089_RS02700	COG0509	glycine decarboxylation via glycine cleavage system
I7089_RS02705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I7089_RS02710	COG2011	ABC-type metal ion transport system permease component
I7089_RS02715	COG1464	Belongs to the NlpA lipoprotein family
I7089_RS02725	COG0719	Fe-S assembly protein
I7089_RS02730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I7089_RS02740	COG0719	Fe-S assembly protein
I7089_RS02820	COG1136	(ABC) transporter
I7089_RS02820	COG0577	efflux transmembrane transporter activity
I7089_RS02830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I7089_RS02840	COG1597	lipid kinase activity
I7089_RS02875	COG1733	regulation of RNA biosynthetic process
I7089_RS02885	COG3764	Sortase (surface protein transpeptidase)
I7089_RS02890	COG3711	transcriptional antiterminator
I7089_RS02895	COG1263	PTS System
I7089_RS02895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS02895	COG2190	(PTS) system
I7089_RS02900	COG2723	6-phospho-beta-galactosidase activity
I7089_RS02905	COG2188	Transcriptional regulator
I7089_RS02915	COG1611	Belongs to the LOG family
I7089_RS02925	COG1428	Deoxynucleoside kinase
I7089_RS02945	COG2723	6-phospho-beta-galactosidase activity
I7089_RS02955	COG1368	sulfuric ester hydrolase activity
I7089_RS02965	COG0105	UTP biosynthetic process
I7089_RS02970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I7089_RS02975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7089_RS02980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I7089_RS02985	COG2011	ABC-type metal ion transport system permease component
I7089_RS02990	COG1464	Belongs to the NlpA lipoprotein family
I7089_RS03000	COG1757	Na H antiporter
I7089_RS03015	COG1113	amino acid transport
I7089_RS03025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I7089_RS03030	COG1929	Belongs to the glycerate kinase type-1 family
I7089_RS03035	COG0488	(ABC) transporter
I7089_RS03050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I7089_RS03055	COG1263	PTS System
I7089_RS03055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS03070	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I7089_RS03075	COG1131	(ABC) transporter
I7089_RS03095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I7089_RS03110	COG0346	lactoylglutathione lyase activity
I7089_RS03135	COG0561	phosphatase activity
I7089_RS03140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I7089_RS03145	COG0280	phosphate acetyltransferase
I7089_RS03150	COG0802	atpase or kinase
I7089_RS03155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I7089_RS03165	COG0708	Exodeoxyribonuclease III
I7089_RS03175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I7089_RS03200	COG1053	succinate dehydrogenase
I7089_RS03210	COG0702	epimerase
I7089_RS03215	COG4684	Psort location CytoplasmicMembrane, score
I7089_RS03220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I7089_RS03225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I7089_RS03230	COG0604	alcohol dehydrogenase
I7089_RS03240	COG3842	ATPase activity
I7089_RS03245	COG1176	ABC-type spermidine putrescine transport system, permease component I
I7089_RS03250	COG1177	transmembrane transport
I7089_RS03255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I7089_RS03260	COG3829	transcription factor binding
I7089_RS03275	COG3715	PTS system
I7089_RS03280	COG3716	PTS system mannose fructose sorbose family IID component
I7089_RS03295	COG1940	carbohydrate kinase activity
I7089_RS03325	COG0582	viral genome integration into host DNA
I7089_RS03330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I7089_RS03340	COG0789	Transcriptional regulator
I7089_RS03350	COG0504	CTP synthase activity
I7089_RS03360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I7089_RS03365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I7089_RS03370	COG0254	rRNA binding
I7089_RS03390	COG1349	DNA-binding transcription factor activity
I7089_RS03400	COG2814	Major facilitator Superfamily
I7089_RS03410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I7089_RS03430	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I7089_RS03435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I7089_RS03440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I7089_RS03445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I7089_RS03450	COG3870	Protein conserved in bacteria
I7089_RS03455	COG0470	DNA polymerase III
I7089_RS03460	COG1774	PSP1 C-terminal conserved region
I7089_RS03465	COG4467	Involved in initiation control of chromosome replication
I7089_RS03480	COG0602	queuosine metabolic process
I7089_RS03485	COG1328	CTP reductase activity
I7089_RS03490	COG1136	(ABC) transporter
I7089_RS03495	COG0577	efflux transmembrane transporter activity
I7089_RS03505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I7089_RS03510	COG1696	Membrane protein involved in D-alanine export
I7089_RS03515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I7089_RS03520	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I7089_RS03525	COG1363	Peptidase, m42
I7089_RS03535	COG1234	tRNA 3'-trailer cleavage
I7089_RS03540	COG0095	Lipoate-protein ligase
I7089_RS03550	COG3328	transposase activity
I7089_RS03570	COG3759	membrane
I7089_RS03575	COG0659	secondary active sulfate transmembrane transporter activity
I7089_RS03585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I7089_RS03595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I7089_RS03605	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I7089_RS03605	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I7089_RS03610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7089_RS03610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS03620	COG3715	PTS system
I7089_RS03625	COG3716	PTS system mannose fructose sorbose family IID component
I7089_RS03635	COG2261	transglycosylase associated protein
I7089_RS03640	COG0006	proline dipeptidase activity
I7089_RS03645	COG1302	Protein conserved in bacteria
I7089_RS03650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I7089_RS03655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I7089_RS03660	COG1570	exodeoxyribonuclease VII activity
I7089_RS03665	COG1722	exodeoxyribonuclease VII activity
I7089_RS03675	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I7089_RS03680	COG1438	arginine binding
I7089_RS03685	COG0497	DNA recombination
I7089_RS03725	COG0768	penicillin binding
I7089_RS03760	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I7089_RS03765	COG1799	cell septum assembly
I7089_RS03775	COG2302	S4 RNA-binding domain
I7089_RS03780	COG3599	regulation of cell shape
I7089_RS03785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I7089_RS03790	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I7089_RS03810	COG0673	inositol 2-dehydrogenase activity
I7089_RS03815	COG0513	Belongs to the DEAD box helicase family
I7089_RS03820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I7089_RS03820	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I7089_RS03825	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS03830	COG1447	Phosphotransferase system cellobiose-specific component IIA
I7089_RS03835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS03880	COG2309	aminopeptidase activity
I7089_RS03890	COG0716	FMN binding
I7089_RS03895	COG0024	Methionine aminopeptidase
I7089_RS03900	COG1295	ribonuclease BN
I7089_RS03905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I7089_RS03920	COG1215	transferase activity, transferring glycosyl groups
I7089_RS03925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I7089_RS03935	COG1088	dTDP-glucose 4,6-dehydratase activity
I7089_RS03940	COG1091	dTDP-4-dehydrorhamnose reductase activity
I7089_RS03955	COG1682	transport, permease protein
I7089_RS03965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I7089_RS03970	COG1216	Glycosyl transferase, family 2
I7089_RS03970	COG0438	transferase activity, transferring glycosyl groups
I7089_RS03985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I7089_RS03990	COG0463	Glycosyl transferase, family 2
I7089_RS03995	COG0438	transferase activity, transferring glycosyl groups
I7089_RS04020	COG1086	Polysaccharide biosynthesis protein
I7089_RS04025	COG2089	acid synthase
I7089_RS04030	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I7089_RS04040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I7089_RS04055	COG1083	cytidylyl-transferase
I7089_RS04105	COG3328	transposase activity
I7089_RS04120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I7089_RS04125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I7089_RS04135	COG4585	Histidine kinase
I7089_RS04145	COG0569	domain protein
I7089_RS04175	COG2246	polysaccharide biosynthetic process
I7089_RS04180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I7089_RS04195	COG1316	TRANSCRIPTIONal
I7089_RS04200	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I7089_RS04205	COG3397	chitin binding
I7089_RS04210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I7089_RS04215	COG2137	regulation of response to DNA damage stimulus
I7089_RS04220	COG1194	a g-specific adenine glycosylase
I7089_RS04225	COG3557	Belongs to the UPF0374 family
I7089_RS04235	COG0628	permease
I7089_RS04240	COG1253	flavin adenine dinucleotide binding
I7089_RS04245	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I7089_RS04265	COG0542	response to heat
I7089_RS04270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7089_RS04275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I7089_RS04285	COG0438	transferase activity, transferring glycosyl groups
I7089_RS04290	COG2084	Dehydrogenase
I7089_RS04295	COG4703	Protein of unknown function (DUF1797)
I7089_RS04300	COG0322	excinuclease ABC activity
I7089_RS04305	COG1846	Transcriptional regulator
I7089_RS04310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I7089_RS04320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I7089_RS04330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I7089_RS04340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I7089_RS04345	COG0439	Biotin carboxylase
I7089_RS04350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I7089_RS04355	COG0825	malonyl-CoA metabolic process
I7089_RS04360	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I7089_RS04365	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I7089_RS04370	COG1534	Rna-binding protein
I7089_RS04375	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I7089_RS04380	COG1713	HD superfamily hydrolase involved in NAD metabolism
I7089_RS04385	COG0799	negative regulation of ribosome biogenesis
I7089_RS04390	COG2226	methyltransferase
I7089_RS04395	COG1323	Belongs to the UPF0348 family
I7089_RS04400	COG0217	transcriptional regulatory protein
I7089_RS04410	COG3973	AAA domain
I7089_RS04415	COG2217	Heavy metal translocating P-type atpase
I7089_RS04420	COG1942	4-Oxalocrotonate Tautomerase
I7089_RS04425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I7089_RS04435	COG1737	Transcriptional regulator
I7089_RS04440	COG0768	penicillin binding
I7089_RS04445	COG0561	phosphatase activity
I7089_RS04450	COG2252	PERMEase
I7089_RS04455	COG2814	Major facilitator Superfamily
I7089_RS04465	COG0587	DNA-directed DNA polymerase activity
I7089_RS04470	COG0205	6-phosphofructokinase activity
I7089_RS04480	COG0583	DNA-binding transcription factor activity
I7089_RS04490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I7089_RS04500	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I7089_RS04505	COG0745	RESPONSE REGULATOR receiver
I7089_RS04510	COG5002	protein histidine kinase activity
I7089_RS04610	COG3711	transcriptional antiterminator
I7089_RS04620	COG2190	(PTS) system
I7089_RS04620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS04620	COG1263	PTS System
I7089_RS04625	COG1486	melibiose metabolic process
I7089_RS04630	COG1263	PTS System
I7089_RS04630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS04630	COG2190	(PTS) system
I7089_RS04635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS04655	COG1349	DNA-binding transcription factor activity
I7089_RS04680	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I7089_RS04685	COG3623	hexulose-6-phosphate isomerase
I7089_RS04695	COG0456	acetyltransferase
I7089_RS04715	COG3711	transcriptional antiterminator
I7089_RS04735	COG3775	system Galactitol-specific IIC component
I7089_RS04750	COG0400	carboxylic ester hydrolase activity
I7089_RS04755	COG0346	lactoylglutathione lyase activity
I7089_RS04760	COG2188	Transcriptional regulator
I7089_RS04765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS04770	COG2723	6-phospho-beta-galactosidase activity
I7089_RS04775	COG0589	response to stress
I7089_RS04790	COG1393	Belongs to the ArsC family
I7089_RS04800	COG0351	phosphomethylpyrimidine kinase
I7089_RS04805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I7089_RS04810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I7089_RS04820	COG3425	synthase
I7089_RS04825	COG0183	Belongs to the thiolase family
I7089_RS04840	COG0656	L-ascorbic acid biosynthetic process
I7089_RS04860	COG0392	lysyltransferase activity
I7089_RS04860	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I7089_RS04865	COG0596	Alpha beta hydrolase
I7089_RS04870	COG0741	lytic transglycosylase activity
I7089_RS04880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I7089_RS04885	COG0358	DNA primase activity
I7089_RS04890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I7089_RS04900	COG2996	Protein conserved in bacteria
I7089_RS04905	COG0735	belongs to the Fur family
I7089_RS04915	COG4974	Belongs to the 'phage' integrase family
I7089_RS04925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I7089_RS04930	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I7089_RS04935	COG1187	pseudouridine synthase activity
I7089_RS04940	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I7089_RS04945	COG1288	antiporter activity
I7089_RS04950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I7089_RS04970	COG0514	ATP-dependent DNA helicase (RecQ)
I7089_RS04980	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I7089_RS04985	COG0539	negative regulation of cytoplasmic translation
I7089_RS04990	COG1160	GTP binding
I7089_RS04995	COG0776	regulation of translation
I7089_RS05010	COG0457	Tetratricopeptide repeat
I7089_RS05015	COG5582	Belongs to the UPF0302 family
I7089_RS05020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I7089_RS05025	COG1694	Mazg nucleotide pyrophosphohydrolase
I7089_RS05030	COG0617	tRNA 3'-terminal CCA addition
I7089_RS05050	COG0025	NhaP-type Na H and K H
I7089_RS05055	COG0488	(ABC) transporter
I7089_RS05060	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I7089_RS05070	COG1272	protein, Hemolysin III
I7089_RS05075	COG1307	EDD domain protein, DegV family
I7089_RS05080	COG2755	lipolytic protein G-D-S-L family
I7089_RS05085	COG4698	Protein conserved in bacteria
I7089_RS05095	COG4479	Belongs to the UPF0346 family
I7089_RS05100	COG0681	Belongs to the peptidase S26 family
I7089_RS05120	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I7089_RS05125	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I7089_RS05130	COG0758	DNA mediated transformation
I7089_RS05135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I7089_RS05140	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I7089_RS05145	COG4974	Belongs to the 'phage' integrase family
I7089_RS05150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I7089_RS05155	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I7089_RS05175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I7089_RS05180	COG1832	CoA-binding protein
I7089_RS05185	COG0187	DNA topoisomerase II activity
I7089_RS05195	COG1882	Formate acetyltransferase
I7089_RS05200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I7089_RS05205	COG1227	inorganic diphosphatase activity
I7089_RS05225	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I7089_RS05235	COG1073	alpha beta
I7089_RS05240	COG1609	Transcriptional regulator
I7089_RS05250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I7089_RS05260	COG1732	Glycine betaine
I7089_RS05275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I7089_RS05285	COG1116	anion transmembrane transporter activity
I7089_RS05290	COG0084	hydrolase, TatD family'
I7089_RS05295	COG1388	LysM domain
I7089_RS05295	COG3942	CHAP domain
I7089_RS05315	COG3328	transposase activity
I7089_RS05345	COG0436	Aminotransferase
I7089_RS05365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I7089_RS05370	COG4565	transcriptional regulatory protein
I7089_RS05375	COG3290	protein histidine kinase activity
I7089_RS05380	COG3290	protein histidine kinase activity
I7089_RS05390	COG2268	Band 7 protein
I7089_RS05405	COG0673	inositol 2-dehydrogenase activity
I7089_RS05415	COG1876	peptidase activity
I7089_RS05420	COG1388	LysM domain
I7089_RS05420	COG1705	Flagellar rod assembly protein muramidase FlgJ
I7089_RS05430	COG1653	transport
I7089_RS05435	COG1175	transmembrane transport
I7089_RS05440	COG0395	ABC-type sugar transport system, permease component
I7089_RS05450	COG0673	inositol 2-dehydrogenase activity
I7089_RS05455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I7089_RS05460	COG2233	PERMEase
I7089_RS05465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I7089_RS05470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I7089_RS05475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I7089_RS05485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I7089_RS05490	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I7089_RS05495	COG0047	phosphoribosylformylglycinamidine synthase activity
I7089_RS05500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I7089_RS05510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I7089_RS05515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I7089_RS05520	COG0138	bifunctional purine biosynthesis protein purh
I7089_RS05525	COG0151	Belongs to the GarS family
I7089_RS05530	COG4989	oxidoreductase activity
I7089_RS05540	COG2972	Histidine kinase
I7089_RS05550	COG4213	ABC transporter substrate-binding protein
I7089_RS05560	COG4214	carbohydrate transport
I7089_RS05565	COG0516	GMP reductase activity
I7089_RS05570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I7089_RS05580	COG0022	dehydrogenase e1 component
I7089_RS05595	COG4476	Belongs to the UPF0223 family
I7089_RS05600	COG0483	inositol monophosphate 1-phosphatase activity
I7089_RS05605	COG1217	gtp-binding protein TYPA
I7089_RS05610	COG0514	ATP-dependent DNA helicase (RecQ)
I7089_RS05615	COG4838	Belongs to the UPF0358 family
I7089_RS05620	COG0772	Belongs to the SEDS family
I7089_RS05625	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I7089_RS05640	COG4471	UPF0298 protein
I7089_RS05645	COG0742	ribosomal rna small subunit methyltransferase
I7089_RS05650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I7089_RS05655	COG3480	Lon protease (S16) C-terminal proteolytic domain
I7089_RS05660	COG1555	photosystem II stabilization
I7089_RS05660	COG1596	polysaccharide export
I7089_RS05675	COG2131	deaminase
I7089_RS05680	COG0658	competence protein
I7089_RS05680	COG2333	competence protein COMEC
I7089_RS05685	COG1466	dna polymerase III delta subunit
I7089_RS05690	COG0268	Binds directly to 16S ribosomal RNA
I7089_RS05700	COG2707	UPF0756 membrane protein
I7089_RS05705	COG2217	Heavy metal translocating P-type atpase
I7089_RS05710	COG1968	undecaprenyl-diphosphatase activity
I7089_RS05730	COG1666	GTP binding
I7089_RS05735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I7089_RS05740	COG2151	metal-sulfur cluster biosynthetic enzyme
I7089_RS05755	COG3942	CHAP domain
I7089_RS05755	COG1388	LysM domain
I7089_RS05810	COG4990	cell redox homeostasis
I7089_RS05830	COG3104	oligopeptide transport
I7089_RS05840	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I7089_RS05845	COG1074	ATP-dependent DNA helicase activity
I7089_RS05850	COG1733	regulation of RNA biosynthetic process
I7089_RS05855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I7089_RS05860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7089_RS05860	COG0072	phenylalanine-tRNA ligase activity
I7089_RS05870	COG1126	abc transporter atp-binding protein
I7089_RS05875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I7089_RS05880	COG0765	amino acid transport
I7089_RS05885	COG0765	amino acid transport
I7089_RS05890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I7089_RS05895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I7089_RS05905	COG0517	IMP dehydrogenase activity
I7089_RS05910	COG0668	transmembrane transport
I7089_RS05915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I7089_RS05920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I7089_RS05925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I7089_RS05955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I7089_RS05965	COG1234	tRNA 3'-trailer cleavage
I7089_RS05970	COG0300	oxidoreductase activity
I7089_RS05975	COG5416	Lipopolysaccharide assembly protein A domain
I7089_RS05980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I7089_RS05980	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I7089_RS05985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I7089_RS05995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I7089_RS06015	COG1705	Flagellar rod assembly protein muramidase FlgJ
I7089_RS06015	COG1388	LysM domain
I7089_RS06020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I7089_RS06025	COG0735	belongs to the Fur family
I7089_RS06030	COG0446	pyridine nucleotide-disulphide oxidoreductase
I7089_RS06050	COG3935	DnaD domain protein
I7089_RS06055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I7089_RS06065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I7089_RS06070	COG3331	DNA recombination
I7089_RS06075	COG4474	Belongs to the UPF0398 family
I7089_RS06080	COG3599	regulation of cell shape
I7089_RS06090	COG0116	Belongs to the methyltransferase superfamily
I7089_RS06095	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I7089_RS06100	COG1418	mRNA catabolic process
I7089_RS06105	COG0156	8-amino-7-oxononanoate synthase activity
I7089_RS06110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I7089_RS06115	COG0531	amino acid
I7089_RS06130	COG0513	Belongs to the DEAD box helicase family
I7089_RS06135	COG2153	protein acetylation
I7089_RS06140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I7089_RS06145	COG4684	Psort location CytoplasmicMembrane, score
I7089_RS06155	COG0328	RNA-DNA hybrid ribonuclease activity
I7089_RS06165	COG1278	Cold shock
I7089_RS06170	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I7089_RS06185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I7089_RS06190	COG0564	pseudouridine synthase activity
I7089_RS06200	COG2233	PERMEase
I7089_RS06205	COG0540	Belongs to the ATCase OTCase family
I7089_RS06210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I7089_RS06215	COG0505	Belongs to the CarA family
I7089_RS06220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I7089_RS06225	COG0543	2 iron, 2 sulfur cluster binding
I7089_RS06235	COG0284	orotidine-5'-phosphate decarboxylase activity
I7089_RS06265	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I7089_RS06280	COG4120	Belongs to the binding-protein-dependent transport system permease family
I7089_RS06290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I7089_RS06325	COG0039	L-malate dehydrogenase activity
I7089_RS06345	COG3037	sugar-specific permease SgaT UlaA
I7089_RS06355	COG3711	transcriptional antiterminator
I7089_RS06365	COG0673	inositol 2-dehydrogenase activity
I7089_RS06415	COG0745	RESPONSE REGULATOR receiver
I7089_RS06420	COG5002	protein histidine kinase activity
I7089_RS06425	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I7089_RS06450	COG0351	phosphomethylpyrimidine kinase
I7089_RS06460	COG4475	Protein of unknown function (DUF436)
I7089_RS06465	COG0366	Alpha amylase catalytic
I7089_RS06480	COG1307	EDD domain protein, DegV family
I7089_RS06485	COG2244	polysaccharide biosynthetic process
I7089_RS06535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I7089_RS06540	COG0194	GDP metabolic process
I7089_RS06565	COG0765	amino acid transport
I7089_RS06570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I7089_RS06580	COG0167	dihydroorotate dehydrogenase activity
I7089_RS06595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I7089_RS06605	COG3833	ABC-type maltose transport systems, permease component
I7089_RS06610	COG1175	transmembrane transport
I7089_RS06615	COG2182	Extracellular solute-binding protein
I7089_RS06620	COG0366	Alpha amylase catalytic
I7089_RS06625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I7089_RS06635	COG1764	response to oxidative stress
I7089_RS06640	COG1846	Transcriptional regulator
I7089_RS06645	COG0628	permease
I7089_RS06660	COG1312	Catalyzes the dehydration of D-mannonate
I7089_RS06665	COG0246	Mannitol dehydrogenase
I7089_RS06675	COG0450	alkyl hydroperoxide reductase
I7089_RS06720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I7089_RS06735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I7089_RS06765	COG2946	Replication initiation factor
I7089_RS06785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I7089_RS06805	COG0004	ammonium transporteR
I7089_RS06810	COG2261	transglycosylase associated protein
I7089_RS06840	COG3655	Transcriptional regulator
I7089_RS06855	COG2261	transglycosylase associated protein
I7089_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
I7089_RS06890	COG1442	glycosyl transferase family 8
I7089_RS06895	COG1442	glycosyl transferase family 8
I7089_RS06900	COG0561	phosphatase activity
I7089_RS06925	COG1476	TRANSCRIPTIONal
I7089_RS06940	COG1278	Cold shock
I7089_RS06955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7089_RS06960	COG1312	Catalyzes the dehydration of D-mannonate
I7089_RS06980	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS06985	COG3716	PTS system mannose fructose sorbose family IID component
I7089_RS06995	COG0371	Dehydrogenase
I7089_RS07010	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I7089_RS07015	COG1737	Transcriptional regulator
I7089_RS07015	COG0837	glucose binding
I7089_RS07025	COG2272	Belongs to the type-B carboxylesterase lipase family
I7089_RS07030	COG1073	alpha beta
I7089_RS07065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I7089_RS07085	COG3732	PTS system glucitol sorbitol-specific
I7089_RS07090	COG3730	PTS system glucitol sorbitol-specific
I7089_RS07100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7089_RS07100	COG3711	transcriptional antiterminator
I7089_RS07125	COG3328	transposase activity
I7089_RS07135	COG4974	Belongs to the 'phage' integrase family
I7089_RS07140	COG0582	viral genome integration into host DNA
I7089_RS07160	COG3250	beta-galactosidase activity
I7089_RS07175	COG2211	Major facilitator Superfamily
I7089_RS07185	COG1904	glucuronate isomerase
I7089_RS07190	COG1312	Catalyzes the dehydration of D-mannonate
I7089_RS07195	COG0246	Mannitol dehydrogenase
I7089_RS07200	COG2188	Transcriptional regulator
I7089_RS07255	COG0433	COG0433 Predicted ATPase
I7089_RS07300	COG2946	Replication initiation factor
I7089_RS07360	COG0481	GTPase activity
I7089_RS07380	COG0542	response to heat
I7089_RS07395	COG1597	lipid kinase activity
I7089_RS07400	COG2195	Cleaves the N-terminal amino acid of tripeptides
I7089_RS07405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I7089_RS07410	COG2384	SAM-dependent methyltransferase
I7089_RS07420	COG1484	DNA-dependent DNA replication
I7089_RS07430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I7089_RS07440	COG0237	dephospho-CoA kinase activity
I7089_RS07445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I7089_RS07450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I7089_RS07450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I7089_RS07465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I7089_RS07470	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I7089_RS07475	COG3091	SprT-like family
I7089_RS07480	COG2183	response to ionizing radiation
I7089_RS07490	COG1054	Belongs to the UPF0176 family
I7089_RS07505	COG0546	phosphoglycolate phosphatase activity
I7089_RS07510	COG0588	phosphoglycerate mutase activity
I7089_RS07555	COG2207	Transcriptional regulator
I7089_RS07555	COG4753	response regulator
I7089_RS07565	COG2972	Histidine kinase
I7089_RS07570	COG0077	Prephenate dehydratase
I7089_RS07575	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I7089_RS07580	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I7089_RS07585	COG0287	Prephenate dehydrogenase
I7089_RS07590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I7089_RS07600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I7089_RS07605	COG3250	beta-galactosidase activity
I7089_RS07620	COG1609	Transcriptional regulator
I7089_RS07630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I7089_RS07640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I7089_RS07645	COG1597	lipid kinase activity
I7089_RS07650	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I7089_RS07655	COG0154	amidase activity
I7089_RS07660	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I7089_RS07665	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I7089_RS07670	COG0210	DNA helicase
I7089_RS07680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7089_RS07680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7089_RS07680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7089_RS07685	COG1105	Belongs to the carbohydrate kinase PfkB family
I7089_RS07690	COG1349	DNA-binding transcription factor activity
I7089_RS07710	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I7089_RS07715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I7089_RS07720	COG0544	peptidyl-prolyl cis-trans isomerase activity
I7089_RS07730	COG1714	RDD family
I7089_RS07745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I7089_RS07755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I7089_RS07825	COG1481	regulation of sporulation
I7089_RS07830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I7089_RS07835	COG1660	Displays ATPase and GTPase activities
I7089_RS07850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I7089_RS07855	COG0556	nucleotide-excision repair
I7089_RS07860	COG0765	amino acid transport
I7089_RS07865	COG1126	abc transporter atp-binding protein
I7089_RS07870	COG0484	heat shock protein binding
I7089_RS07875	COG0443	Heat shock 70 kDa protein
I7089_RS07880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I7089_RS07885	COG1420	regulation of RNA biosynthetic process
I7089_RS07890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I7089_RS07935	COG0693	protein deglycase activity
I7089_RS07945	COG1619	proteins homologs of microcin C7 resistance protein MccF
I7089_RS07955	COG5646	InterPro IPR014922
I7089_RS07965	COG4975	Glucose uptake
I7089_RS07980	COG0196	riboflavin kinase activity
I7089_RS07985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I7089_RS07990	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I7089_RS07995	COG1175	transmembrane transport
I7089_RS08000	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I7089_RS08015	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I7089_RS08020	COG0195	Participates in both transcription termination and antitermination
I7089_RS08025	COG0779	Required for maturation of 30S ribosomal subunits
I7089_RS08030	COG2176	DNA-directed DNA polymerase activity
I7089_RS08035	COG0442	prolyl-tRNA aminoacylation
I7089_RS08040	COG0750	zinc metalloprotease
I7089_RS08045	COG4589	Belongs to the CDS family
I7089_RS08050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I7089_RS08060	COG0233	cytoplasmic translational termination
I7089_RS08065	COG0528	UMP kinase activity
I7089_RS08070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I7089_RS08075	COG0052	Belongs to the universal ribosomal protein uS2 family
I7089_RS08080	COG1438	arginine binding
I7089_RS08090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7089_RS08095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7089_RS08100	COG0018	arginyl-trna synthetase
I7089_RS08115	COG2235	arginine
I7089_RS08120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I7089_RS08130	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I7089_RS08135	COG0456	acetyltransferase
I7089_RS08145	COG1214	PFAM Peptidase M22, glycoprotease
I7089_RS08155	COG1609	Transcriptional regulator
I7089_RS08160	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I7089_RS08165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I7089_RS08180	COG3189	MarR family transcriptional regulator
I7089_RS08185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I7089_RS08190	COG1940	carbohydrate kinase activity
I7089_RS08205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I7089_RS08210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7089_RS08215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7089_RS08220	COG1120	ATPase activity
I7089_RS08235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I7089_RS08240	COG4876	unkown
I7089_RS08245	COG0367	asparagine synthase
I7089_RS08250	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I7089_RS08260	COG1309	transcriptional regulator
I7089_RS08280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I7089_RS08295	COG0584	glycerophosphoryl diester phosphodiesterase
I7089_RS08325	COG0166	Belongs to the GPI family
I7089_RS08330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I7089_RS08335	COG2081	HI0933 family
I7089_RS08340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I7089_RS08345	COG0710	3-dehydroquinate dehydratase activity
I7089_RS08350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I7089_RS08355	COG1368	sulfuric ester hydrolase activity
I7089_RS08370	COG3850	Histidine kinase
I7089_RS08370	COG5002	protein histidine kinase activity
I7089_RS08375	COG0745	RESPONSE REGULATOR receiver
I7089_RS08400	COG3328	transposase activity
I7089_RS08415	COG3328	transposase activity
I7089_RS08430	COG1956	GAF domain-containing protein
I7089_RS08435	COG3527	Alpha-acetolactate decarboxylase
I7089_RS08440	COG0028	Belongs to the TPP enzyme family
I7089_RS08450	COG3328	transposase activity
I7089_RS08460	COG0395	ABC-type sugar transport system, permease component
I7089_RS08470	COG0583	DNA-binding transcription factor activity
I7089_RS08475	COG0789	Transcriptional regulator
I7089_RS08480	COG2814	Major facilitator Superfamily
I7089_RS08535	COG4974	Belongs to the 'phage' integrase family
I7089_RS08560	COG4372	Transposase
I7089_RS08590	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7089_RS08590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS08595	COG3716	PTS system mannose fructose sorbose family IID component
I7089_RS08600	COG3715	PTS system
I7089_RS08605	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I7089_RS08605	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I7089_RS08610	COG1940	carbohydrate kinase activity
I7089_RS08615	COG2190	(PTS) system
I7089_RS08630	COG1609	Transcriptional regulator
I7089_RS08655	COG3385	transposase activity
I7089_RS08675	COG0741	lytic transglycosylase activity
I7089_RS08675	COG0791	NLP P60 protein
I7089_RS08705	COG1196	nuclear chromosome segregation
I7089_RS08735	COG2946	Replication initiation factor
I7089_RS08750	COG1674	ftsk spoiiie
I7089_RS08780	COG0335	large ribosomal subunit rRNA binding
I7089_RS08785	COG0336	Belongs to the RNA methyltransferase TrmD family
I7089_RS08790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I7089_RS08800	COG1837	Belongs to the UPF0109 family
I7089_RS08805	COG0228	four-way junction DNA binding
I7089_RS08810	COG0431	NADPH-dependent FMN reductase
I7089_RS08815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I7089_RS08820	COG0519	Catalyzes the synthesis of GMP from XMP
I7089_RS08825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I7089_RS08830	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I7089_RS08840	COG0745	RESPONSE REGULATOR receiver
I7089_RS08845	COG5002	protein histidine kinase activity
I7089_RS08850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I7089_RS08860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I7089_RS08885	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I7089_RS08905	COG3328	transposase activity
I7089_RS08945	COG0714	Associated with various cellular activities
I7089_RS08965	COG2217	Heavy metal translocating P-type atpase
I7089_RS08970	COG2217	Heavy metal translocating P-type atpase
I7089_RS08975	COG2608	mercury ion transmembrane transporter activity
I7089_RS08980	COG3682	Transcriptional regulator
I7089_RS08990	COG0531	amino acid
I7089_RS08995	COG2217	Heavy metal translocating P-type atpase
I7089_RS09015	COG0017	Asparaginyl-tRNA synthetase
I7089_RS09020	COG0436	Aminotransferase
I7089_RS09030	COG1199	ATP-dependent helicase activity
I7089_RS09030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I7089_RS09035	COG1278	Cold shock
I7089_RS09055	COG1686	Belongs to the peptidase S11 family
I7089_RS09065	COG0038	chloride channel
I7089_RS09080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I7089_RS09085	COG1254	Belongs to the acylphosphatase family
I7089_RS09090	COG0706	membrane insertase activity
I7089_RS09095	COG3684	Belongs to the aldolase LacD family
I7089_RS09100	COG4372	Transposase
I7089_RS09160	COG1216	Glycosyl transferase, family 2
I7089_RS09165	COG0438	transferase activity, transferring glycosyl groups
I7089_RS09185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I7089_RS09190	COG4464	protein tyrosine phosphatase activity
I7089_RS09195	COG0489	protein tyrosine kinase activity
I7089_RS09200	COG3944	biosynthesis protein
I7089_RS09205	COG1316	TRANSCRIPTIONal
I7089_RS09215	COG0751	glycine-tRNA ligase activity
I7089_RS09220	COG0752	glycyl-tRNA synthetase alpha subunit
I7089_RS09225	COG1381	Involved in DNA repair and RecF pathway recombination
I7089_RS09230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I7089_RS09235	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I7089_RS09240	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I7089_RS09250	COG1702	phosphate starvation-inducible protein PhoH
I7089_RS09255	COG1114	Component of the transport system for branched-chain amino acids
I7089_RS09260	COG1610	YqeY-like protein
I7089_RS09265	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I7089_RS09270	COG0735	belongs to the Fur family
I7089_RS09275	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I7089_RS09280	COG0640	Transcriptional regulator
I7089_RS09285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I7089_RS09290	COG0492	ferredoxin-NADP+ reductase activity
I7089_RS09295	COG2723	6-phospho-beta-galactosidase activity
I7089_RS09300	COG1486	melibiose metabolic process
I7089_RS09305	COG1737	Transcriptional regulator
I7089_RS09310	COG1263	PTS System
I7089_RS09310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS09310	COG2190	(PTS) system
I7089_RS09320	COG1132	(ABC) transporter
I7089_RS09325	COG1132	(ABC) transporter
I7089_RS09330	COG3763	UPF0154 protein
I7089_RS09335	COG1914	H( )-stimulated, divalent metal cation uptake system
I7089_RS09345	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I7089_RS09355	COG3328	transposase activity
I7089_RS09390	COG1609	Transcriptional regulator
I7089_RS09400	COG4980	gas vesicle protein
I7089_RS09410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I7089_RS09415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I7089_RS09420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I7089_RS09425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I7089_RS09430	COG1950	PFAM Membrane protein of
I7089_RS09455	COG0704	Plays a role in the regulation of phosphate uptake
I7089_RS09460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I7089_RS09465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I7089_RS09470	COG0581	inorganic phosphate transmembrane transporter activity
I7089_RS09475	COG0573	inorganic phosphate transmembrane transporter activity
I7089_RS09480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I7089_RS09485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I7089_RS09490	COG2177	Part of the ABC transporter FtsEX involved in
I7089_RS09495	COG2884	Cell division ATP-binding protein ftsE
I7089_RS09505	COG0653	protein targeting
I7089_RS09520	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I7089_RS09525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS09535	COG1739	Uncharacterized protein family UPF0029
I7089_RS09540	COG2188	Transcriptional regulator
I7089_RS09565	COG1940	carbohydrate kinase activity
I7089_RS09585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I7089_RS09600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I7089_RS09605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I7089_RS09610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I7089_RS09615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I7089_RS09620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I7089_RS09625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I7089_RS09630	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I7089_RS09635	COG0356	it plays a direct role in the translocation of protons across the membrane
I7089_RS09645	COG1647	Serine aminopeptidase, S33
I7089_RS09650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I7089_RS09655	COG2388	GCN5-related N-acetyl-transferase
I7089_RS09665	COG1957	nucleoside hydrolase
I7089_RS09675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I7089_RS09685	COG0149	triose-phosphate isomerase activity
I7089_RS09690	COG0126	phosphoglycerate kinase activity
I7089_RS09700	COG2390	Transcriptional regulator
I7089_RS09705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I7089_RS09725	COG1595	DNA-templated transcription, initiation
I7089_RS09740	COG0095	Lipoate-protein ligase
I7089_RS09745	COG1078	dGTPase activity
I7089_RS09750	COG0561	phosphatase activity
I7089_RS09755	COG0494	nUDIX hydrolase
I7089_RS09760	COG0346	lactoylglutathione lyase activity
I7089_RS09770	COG2423	ornithine cyclodeaminase activity
I7089_RS09775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I7089_RS09780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I7089_RS09785	COG1394	ATPase activity, coupled to movement of substances
I7089_RS09790	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I7089_RS09795	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I7089_RS09800	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
I7089_RS09805	COG1527	subunit (C
I7089_RS09810	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
I7089_RS09815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I7089_RS09820	COG1269	ATP hydrolysis coupled proton transport
I7089_RS09830	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I7089_RS09835	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I7089_RS09845	COG4152	abc transporter atp-binding protein
I7089_RS09850	COG0322	excinuclease ABC activity
I7089_RS09860	COG3118	belongs to the thioredoxin family
I7089_RS09865	COG1193	negative regulation of DNA recombination
I7089_RS09880	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I7089_RS09895	COG1136	(ABC) transporter
I7089_RS09905	COG0446	pyridine nucleotide-disulphide oxidoreductase
I7089_RS09935	COG1304	FMN binding
I7089_RS09945	COG0281	malic enzyme
I7089_RS09985	COG4695	Portal protein
I7089_RS10065	COG4974	Belongs to the 'phage' integrase family
I7089_RS10070	COG3906	Belongs to the UPF0473 family
I7089_RS10075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I7089_RS10080	COG4472	Bacterial protein of unknown function (DUF965)
I7089_RS10110	COG4555	ABC transporter
I7089_RS10120	COG3689	TIGRFAM TIGR03943 family protein
I7089_RS10125	COG0701	Predicted permease
I7089_RS10130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7089_RS10135	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I7089_RS10140	COG0488	(ABC) transporter
I7089_RS10145	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I7089_RS10160	COG0395	ABC-type sugar transport system, permease component
I7089_RS10180	COG2207	Transcriptional regulator
I7089_RS10180	COG0662	Cupin 2, conserved barrel domain protein
I7089_RS10185	COG0446	pyridine nucleotide-disulphide oxidoreductase
I7089_RS10200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I7089_RS10205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I7089_RS10210	COG0584	glycerophosphoryl diester phosphodiesterase
I7089_RS10220	COG0740	serine-type endopeptidase activity
I7089_RS10225	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I7089_RS10235	COG1132	(ABC) transporter
I7089_RS10245	COG5503	Protein of unknown function (DUF1447)
I7089_RS10260	COG1278	Cold shock
I7089_RS10350	COG0741	lytic transglycosylase activity
I7089_RS10350	COG0739	heme binding
I7089_RS10350	COG1196	nuclear chromosome segregation
I7089_RS10495	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I7089_RS10505	COG3723	Recombinational DNA repair protein, rece pathway
I7089_RS10510	COG5377	YqaJ viral recombinase family
I7089_RS10560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I7089_RS10565	COG2003	Belongs to the UPF0758 family
I7089_RS10570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7089_RS10575	COG0285	dihydrofolate synthase activity
I7089_RS10580	COG0525	valine-tRNA ligase activity
I7089_RS10585	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I7089_RS10590	COG0301	tRNA thio-modification
I7089_RS10595	COG1104	cysteine desulfurase activity
I7089_RS10605	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I7089_RS10615	COG0561	phosphatase activity
I7089_RS10620	COG1801	Protein of unknown function DUF72
I7089_RS10640	COG3579	cysteine-type endopeptidase activity
I7089_RS10690	COG4372	Transposase
I7089_RS10720	COG1098	S1 RNA binding domain
I7089_RS10725	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I7089_RS10740	COG0492	ferredoxin-NADP+ reductase activity
I7089_RS10745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I7089_RS10760	COG4470	Protein conserved in bacteria
I7089_RS10765	COG0737	Belongs to the 5'-nucleotidase family
I7089_RS10775	COG0590	tRNA wobble adenosine to inosine editing
I7089_RS10780	COG2508	Transcriptional regulator
I7089_RS10790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I7089_RS10790	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I7089_RS10805	COG2738	Putative neutral zinc metallopeptidase
I7089_RS10810	COG2824	Alkylphosphonate utilization operon protein PhnA
I7089_RS10815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I7089_RS10820	COG4109	DRTGG domain
I7089_RS10825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I7089_RS10845	COG0577	efflux transmembrane transporter activity
I7089_RS10850	COG1136	(ABC) transporter
I7089_RS10860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I7089_RS10865	COG1288	antiporter activity
I7089_RS10870	COG4821	SIS domain
I7089_RS10885	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I7089_RS10890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I7089_RS10895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I7089_RS10900	COG3716	PTS system mannose fructose sorbose family IID component
I7089_RS10905	COG3715	PTS system
I7089_RS10930	COG1132	(ABC) transporter
I7089_RS10935	COG1132	(ABC) transporter
I7089_RS10945	COG1803	Methylglyoxal synthase
I7089_RS10950	COG3842	ATPase activity
I7089_RS10960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I7089_RS10965	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I7089_RS10970	COG0084	hydrolase, TatD family'
I7089_RS10975	COG0531	amino acid
I7089_RS10985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7089_RS10985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7089_RS11000	COG0675	Transposase, IS605 OrfB family
I7089_RS11005	COG4608	Belongs to the ABC transporter superfamily
I7089_RS11010	COG0444	Belongs to the ABC transporter superfamily
I7089_RS11015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I7089_RS11020	COG0601	transmembrane transport
I7089_RS11030	COG4166	transmembrane transport
I7089_RS11045	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I7089_RS11050	COG1280	lysine exporter protein (LysE YggA)
I7089_RS11050	COG1674	ftsk spoiiie
I7089_RS11055	COG2723	6-phospho-beta-galactosidase activity
I7089_RS11060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I7089_RS11065	COG1126	abc transporter atp-binding protein
I7089_RS11070	COG0765	amino acid transport
I7089_RS11115	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I7089_RS11125	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I7089_RS11130	COG0009	L-threonylcarbamoyladenylate synthase
I7089_RS11140	COG2890	protein-(glutamine-N5) methyltransferase activity
I7089_RS11145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I7089_RS11150	COG1435	thymidine kinase activity
I7089_RS11160	COG2226	methyltransferase
I7089_RS11165	COG0681	Belongs to the peptidase S26 family
I7089_RS11185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I7089_RS11190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I7089_RS11195	COG3442	glutamine amidotransferase
I7089_RS11200	COG0246	Mannitol dehydrogenase
I7089_RS11205	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7089_RS11210	COG2213	PTS system mannitol-specific
I7089_RS11215	COG1131	(ABC) transporter
I7089_RS11225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7089_RS11230	COG3711	transcriptional antiterminator
I7089_RS11235	COG2213	PTS system mannitol-specific
I7089_RS11240	COG1482	cell wall glycoprotein biosynthetic process
I7089_RS11255	COG1132	(ABC) transporter
I7089_RS11275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I7089_RS11285	COG0628	permease
I7089_RS11295	COG2706	6-phosphogluconolactonase activity
I7089_RS11310	COG1368	sulfuric ester hydrolase activity
I7089_RS11320	COG2160	L-arabinose isomerase activity
I7089_RS11325	COG0235	Class ii aldolase
I7089_RS11345	COG3940	Belongs to the glycosyl hydrolase 43 family
I7089_RS11350	COG3534	alpha-L-arabinofuranosidase
I7089_RS11360	COG0395	ABC-type sugar transport system, permease component
I7089_RS11365	COG1175	transmembrane transport
I7089_RS11385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I7089_RS11390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I7089_RS11400	COG0789	Transcriptional regulator
I7089_RS11405	COG1609	Transcriptional regulator
I7089_RS11435	COG0459	protein refolding
I7089_RS11440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I7089_RS11450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS11455	COG2910	NAD(P)H-binding
I7089_RS11460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I7089_RS11475	COG5002	protein histidine kinase activity
I7089_RS11480	COG0745	RESPONSE REGULATOR receiver
I7089_RS11485	COG1307	EDD domain protein, DegV family
I7089_RS11525	COG3448	diguanylate cyclase activity
I7089_RS11525	COG4175	Glycine betaine
I7089_RS11550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I7089_RS11555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I7089_RS11565	COG0628	permease
I7089_RS11570	COG1285	pathogenesis
I7089_RS11575	COG0363	glucosamine-6-phosphate deaminase activity
I7089_RS11580	COG0488	(ABC) transporter
I7089_RS11595	COG2814	Major facilitator Superfamily
I7089_RS11605	COG0222	ribosome binding
I7089_RS11610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I7089_RS11615	COG0081	regulation of translation
I7089_RS11620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I7089_RS11625	COG1760	l-serine dehydratase
I7089_RS11630	COG1760	l-serine dehydratase
I7089_RS11635	COG1304	FMN binding
I7089_RS11640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I7089_RS11645	COG0250	Participates in transcription elongation, termination and antitermination
I7089_RS11650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I7089_RS11655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I7089_RS11670	COG1597	lipid kinase activity
I7089_RS11685	COG1131	(ABC) transporter
I7089_RS11690	COG4585	Histidine kinase
I7089_RS11695	COG2197	response regulator
I7089_RS11705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I7089_RS11715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I7089_RS11720	COG2226	methyltransferase
I7089_RS11725	COG3142	Participates in the control of copper homeostasis
I7089_RS11730	COG2239	Acts as a magnesium transporter
I7089_RS11735	COG0564	pseudouridine synthase activity
I7089_RS11740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I7089_RS11745	COG2357	RelA SpoT domain protein
I7089_RS11750	COG4116	CYTH
I7089_RS11775	COG4862	establishment of competence for transformation
I7089_RS11780	COG1393	Belongs to the ArsC family
I7089_RS11795	COG0419	ATPase involved in DNA repair
I7089_RS11800	COG0420	3'-5' exonuclease activity
I7089_RS11805	COG0204	Acyl-transferase
I7089_RS11810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I7089_RS11815	COG2827	Endonuclease containing a URI domain
I7089_RS11820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I7089_RS11820	COG2755	lipolytic protein G-D-S-L family
I7089_RS11825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I7089_RS11830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I7089_RS11835	COG0124	histidyl-tRNA synthetase
I7089_RS11840	COG0667	Aldo Keto reductase
I7089_RS11845	COG2124	cytochrome p450
I7089_RS11850	COG1490	D-aminoacyl-tRNA deacylase activity
I7089_RS11855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I7089_RS11860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I7089_RS11865	COG2264	protein methyltransferase activity
I7089_RS11875	COG2094	Belongs to the DNA glycosylase MPG family
I7089_RS11880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I7089_RS11895	COG0589	response to stress
I7089_RS11905	COG0488	(ABC) transporter
I7089_RS11910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I7089_RS11915	COG0827	DNA restriction-modification system
I7089_RS11940	COG4537	Required for transformation and DNA binding
I7089_RS11945	COG1459	type II secretion system
I7089_RS11950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I7089_RS11955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I7089_RS11960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I7089_RS11970	COG4473	ABC transporter
I7089_RS11975	COG1131	(ABC) transporter
I7089_RS11980	COG0537	adenosine 5'-monophosphoramidase activity
I7089_RS11990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I7089_RS11995	COG3481	metal-dependent phosphohydrolase, HD sub domain
I7089_RS12000	COG4717	serine-type aminopeptidase activity
I7089_RS12005	COG0420	3'-5' exonuclease activity
I7089_RS12010	COG0561	phosphatase activity
I7089_RS12035	COG2211	Major facilitator Superfamily
I7089_RS12040	COG3507	Belongs to the glycosyl hydrolase 43 family
I7089_RS12055	COG1073	alpha beta
I7089_RS12065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I7089_RS12070	COG1653	transport
I7089_RS12080	COG4209	transmembrane transport
I7089_RS12085	COG0395	ABC-type sugar transport system, permease component
I7089_RS12090	COG2207	Transcriptional regulator
I7089_RS12095	COG1609	Transcriptional regulator
I7089_RS12100	COG0246	Mannitol dehydrogenase
I7089_RS12105	COG2721	sulfolactate sulfo-lyase activity
I7089_RS12110	COG1904	glucuronate isomerase
I7089_RS12115	COG2755	lipolytic protein G-D-S-L family
I7089_RS12125	COG1132	(ABC) transporter
I7089_RS12130	COG3679	Belongs to the UPF0342 family
I7089_RS12135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I7089_RS12140	COG0564	pseudouridine synthase activity
I7089_RS12145	COG1940	carbohydrate kinase activity
I7089_RS12150	COG0383	alpha-mannosidase activity
I7089_RS12170	COG4753	response regulator
I7089_RS12170	COG2207	Transcriptional regulator
I7089_RS12175	COG2972	Histidine kinase
I7089_RS12185	COG1653	transport
I7089_RS12190	COG0395	ABC-type sugar transport system, permease component
I7089_RS12195	COG1175	transmembrane transport
I7089_RS12200	COG1187	pseudouridine synthase activity
I7089_RS12205	COG2244	polysaccharide biosynthetic process
I7089_RS12215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I7089_RS12220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS12235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7089_RS12235	COG3711	transcriptional antiterminator
I7089_RS12280	COG0789	Transcriptional regulator
I7089_RS12280	COG4978	Transcriptional regulator
I7089_RS12290	COG1132	(ABC) transporter
I7089_RS12300	COG0495	leucyl-tRNA aminoacylation
I7089_RS12305	COG1388	LysM domain
I7089_RS12305	COG1705	Flagellar rod assembly protein muramidase FlgJ
I7089_RS12310	COG0671	phosphoesterase, PA-phosphatase related
I7089_RS12315	COG1242	4 iron, 4 sulfur cluster binding
I7089_RS12320	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I7089_RS12370	COG0582	viral genome integration into host DNA
I7089_RS12375	COG3328	transposase activity
I7089_RS12390	COG1132	(ABC) transporter
I7089_RS12395	COG1132	(ABC) transporter
I7089_RS12410	COG0477	Major facilitator Superfamily
I7089_RS12415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I7089_RS12575	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I7089_RS12580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I7089_RS12585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I7089_RS12595	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I7089_RS12600	COG0037	tRNA processing
I7089_RS12605	COG1098	S1 RNA binding domain
I7089_RS12615	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I7089_RS12620	COG2244	polysaccharide biosynthetic process
I7089_RS12625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I7089_RS12630	COG0193	aminoacyl-tRNA hydrolase activity
I7089_RS12635	COG0039	L-malate dehydrogenase activity
I7089_RS12645	COG0217	transcriptional regulatory protein
I7089_RS12670	COG1792	Involved in formation and maintenance of cell shape
I7089_RS12680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I7089_RS12685	COG1162	GTPase activity
I7089_RS12690	COG0515	serine threonine protein kinase
I7089_RS12690	COG2815	serine threonine protein kinase
I7089_RS12695	COG0631	protein serine/threonine phosphatase activity
I7089_RS12700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I7089_RS12700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I7089_RS12705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I7089_RS12710	COG0242	peptide deformylase activity
I7089_RS12715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I7089_RS12720	COG1758	RNA polymerase activity
I7089_RS12725	COG0194	GDP metabolic process
I7089_RS12735	COG1561	YicC-like family, N-terminal region
I7089_RS12745	COG1752	Esterase of the alpha-beta hydrolase superfamily
I7089_RS12760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I7089_RS12765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I7089_RS12770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I7089_RS12775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I7089_RS12780	COG1121	(ABC) transporter
I7089_RS12785	COG0803	Belongs to the bacterial solute-binding protein 9 family
I7089_RS12785	COG3443	Belongs to the bacterial solute-binding protein 9 family
I7089_RS12790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I7089_RS12795	COG0392	lysyltransferase activity
I7089_RS12795	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I7089_RS12800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I7089_RS12810	COG1418	mRNA catabolic process
I7089_RS12815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I7089_RS12820	COG1546	Belongs to the CinA family
I7089_RS12820	COG1058	Belongs to the CinA family
I7089_RS12825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I7089_RS12830	COG1426	Protein conserved in bacteria
I7089_RS12835	COG0612	Peptidase, M16
I7089_RS12840	COG0612	Peptidase, M16
I7089_RS12845	COG1970	mechanosensitive ion channel activity
I7089_RS12850	COG2153	protein acetylation
I7089_RS12860	COG4466	Protein conserved in bacteria
I7089_RS12870	COG3688	RNA-binding protein containing a PIN domain
I7089_RS12875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I7089_RS12880	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I7089_RS12885	COG0215	cysteine-tRNA ligase activity
I7089_RS12890	COG1045	serine acetyltransferase
I7089_RS12895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I7089_RS12900	COG4956	integral membrane protein (PIN domain superfamily)
I7089_RS12910	COG0756	dUTP diphosphatase activity
I7089_RS12920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I7089_RS12925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I7089_RS12940	COG2814	Major facilitator Superfamily
I7089_RS12965	COG0778	Nitroreductase
I7089_RS12975	COG1705	Flagellar rod assembly protein muramidase FlgJ
I7089_RS12975	COG1388	LysM domain
I7089_RS12980	COG4221	oxidoreductase activity
I7089_RS12990	COG0583	DNA-binding transcription factor activity
I7089_RS12995	COG3711	transcriptional antiterminator
I7089_RS13000	COG2190	(PTS) system
I7089_RS13000	COG1263	PTS System
I7089_RS13000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS13005	COG0702	epimerase
I7089_RS13020	COG2207	Transcriptional regulator
I7089_RS13020	COG3708	Transcriptional regulator
I7089_RS13040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I7089_RS13050	COG0604	alcohol dehydrogenase
I7089_RS13055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I7089_RS13060	COG0842	Transport permease protein
I7089_RS13065	COG1131	(ABC) transporter
I7089_RS13075	COG2205	protein histidine kinase activity
I7089_RS13080	COG0745	RESPONSE REGULATOR receiver
I7089_RS13120	COG2188	Transcriptional regulator
I7089_RS13125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7089_RS13130	COG3716	PTS system mannose fructose sorbose family IID component
I7089_RS13135	COG3715	PTS system
I7089_RS13145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7089_RS13150	COG2222	sugar isomerase
I7089_RS13255	COG1674	ftsk spoiiie
I7089_RS13280	COG2946	Replication initiation factor
I7089_RS13320	COG0741	lytic transglycosylase activity
I7089_RS13320	COG0791	NLP P60 protein
I7089_RS13345	COG2814	Major facilitator Superfamily
I7089_RS13355	COG1705	Flagellar rod assembly protein muramidase FlgJ
I7089_RS13355	COG3942	CHAP domain
I7089_RS13360	COG0446	pyridine nucleotide-disulphide oxidoreductase
I7089_RS13375	COG3708	Transcriptional regulator
I7089_RS13375	COG2207	Transcriptional regulator
I7089_RS13410	COG0523	cobalamin synthesis protein
I7089_RS13430	COG3443	Belongs to the bacterial solute-binding protein 9 family
I7089_RS13430	COG0803	Belongs to the bacterial solute-binding protein 9 family
I7089_RS13445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I7089_RS13455	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I7089_RS13460	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I7089_RS13465	COG1132	(ABC) transporter
I7089_RS13470	COG1132	(ABC) transporter
I7089_RS13480	COG1129	ABC transporter
I7089_RS13490	COG1309	transcriptional regulator
I7089_RS13525	COG4974	Belongs to the 'phage' integrase family
I7089_RS13530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I7089_RS13535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I7089_RS13540	COG0783	Belongs to the Dps family
I7089_RS13545	COG1070	Carbohydrate kinase
I7089_RS13550	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I7089_RS13555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I7089_RS13560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7089_RS13570	COG1554	hydrolase, family 65, central catalytic
I7089_RS13575	COG0673	inositol 2-dehydrogenase activity
I7089_RS13580	COG1082	Xylose isomerase domain protein TIM barrel
I7089_RS13585	COG1063	alcohol dehydrogenase
I7089_RS13590	COG0395	ABC-type sugar transport system, permease component
I7089_RS13595	COG1175	transmembrane transport
I7089_RS13600	COG1653	transport
I7089_RS13605	COG0366	Alpha amylase catalytic
I7089_RS13610	COG1609	Transcriptional regulator
I7089_RS13615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I7089_RS13620	COG0085	RNA polymerase activity
I7089_RS13630	COG4120	Belongs to the binding-protein-dependent transport system permease family
I7089_RS13640	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I7089_RS13640	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I7089_RS13655	COG0142	geranyltranstransferase activity
I7089_RS13675	COG4939	FMN-binding domain protein
I7089_RS13690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I7089_RS13695	COG0826	peptidase U32
I7089_RS13700	COG0826	peptidase U32
I7089_RS13705	COG0542	response to heat
I7089_RS13710	COG4463	regulation of RNA biosynthetic process
I7089_RS13785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I7089_RS13790	COG0516	GMP reductase activity
I7089_RS13790	COG0517	IMP dehydrogenase activity
I7089_RS13800	COG0012	GTP binding
I7089_RS13805	COG4481	Protein conserved in bacteria
I7089_RS13810	COG1475	DNA binding
I7089_RS13815	COG1192	Involved in chromosome partitioning
I7089_RS13820	COG0357	Ribosomal RNA small subunit methyltransferase G
I7089_RS13825	COG0445	tRNA wobble uridine modification
I7089_RS13830	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I7089_RS13840	COG1847	R3H domain protein
I7089_RS13845	COG0706	membrane insertase activity
I7089_RS13850	COG0594	ribonuclease P activity
I7089_RS13855	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I7089_RS13935	COG3344	reverse transcriptase
I7089_RS14035	COG0629	single-stranded DNA binding
I7089_RS14080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I7089_RS14090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I7089_RS14110	COG1192	Involved in chromosome partitioning
I7089_RS14170	COG2337	Toxic component of a toxin-antitoxin (TA) module
I7089_RS14255	COG0629	single-stranded DNA binding
I7089_RS14260	COG0629	single-stranded DNA binding
I7089_RS14320	COG3328	transposase activity
I7089_RS14335	COG3775	system Galactitol-specific IIC component
I7089_RS14350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I7089_RS14360	COG4372	Transposase
I7089_RS14395	COG1940	carbohydrate kinase activity
I7089_RS14400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS14400	COG1263	PTS System
I7089_RS14400	COG2190	(PTS) system
I7089_RS14405	COG1621	beta-fructofuranosidase activity
I7089_RS14410	COG1609	Transcriptional regulator
I7089_RS14440	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I7089_RS14445	COG2190	(PTS) system
I7089_RS14445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS14445	COG1263	PTS System
I7089_RS14450	COG2190	(PTS) system
I7089_RS14450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS14450	COG1263	PTS System
I7089_RS14470	COG4974	Belongs to the 'phage' integrase family
I7089_RS14480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7089_RS14490	COG3684	Belongs to the aldolase LacD family
I7089_RS14495	COG2222	sugar isomerase
I7089_RS14500	COG2188	Transcriptional regulator
I7089_RS14515	COG3328	transposase activity
I7089_RS14530	COG3328	transposase activity
I7089_RS14545	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I7089_RS14550	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I7089_RS14555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I7089_RS14575	COG4372	Transposase
I7089_RS14655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I7089_RS14670	COG3409	Peptidoglycan-binding domain 1 protein
I7089_RS14690	COG5002	protein histidine kinase activity
I7089_RS14705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I7089_RS14720	COG3842	ATPase activity
I7089_RS14730	COG0395	ABC-type sugar transport system, permease component
I7089_RS14745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I7089_RS14765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I7089_RS14780	COG1136	(ABC) transporter
I7089_RS14800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7089_RS14835	COG0582	viral genome integration into host DNA
I7089_RS14860	COG2217	Heavy metal translocating P-type atpase
I7089_RS14880	COG2217	Heavy metal translocating P-type atpase
I7089_RS14885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I7089_RS14895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I7089_RS14905	COG3711	transcriptional antiterminator
I7089_RS14910	COG2723	6-phospho-beta-galactosidase activity
I7089_RS14915	COG2190	(PTS) system
I7089_RS14915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7089_RS14915	COG1263	PTS System
I7089_RS14920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I7089_RS14920	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I7089_RS14965	COG1288	antiporter activity
I7089_RS14985	COG2188	Transcriptional regulator
I7089_RS14990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I7089_RS14995	COG2222	sugar isomerase
I7089_RS15020	COG3711	transcriptional antiterminator
I7089_RS15025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7089_RS15030	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I7089_RS15030	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I7089_RS15035	COG2222	sugar isomerase
I7089_RS15040	COG3716	PTS system mannose fructose sorbose family IID component
I7089_RS15045	COG3715	PTS system
I7089_RS15200	COG3344	reverse transcriptase
I7089_RS15245	COG2226	methyltransferase
I7089_RS15255	COG0456	acetyltransferase
I7089_RS15270	COG2378	regulation of single-species biofilm formation
I7089_RS15370	COG2826	transposase and inactivated derivatives, IS30 family
I7089_RS15410	COG4115	mRNA cleavage
I7089_RS15425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I7089_RS15445	COG1192	Involved in chromosome partitioning