locus-tag	class	description
CO997_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO997_RS00010	COG0592	DNA-directed DNA polymerase activity
CO997_RS00015	COG2501	S4 domain
CO997_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO997_RS00025	COG0187	DNA topoisomerase II activity
CO997_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
CO997_RS00040	COG0629	single-stranded DNA binding
CO997_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CO997_RS00055	COG0359	binds to the 23S rRNA
CO997_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
CO997_RS00075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CO997_RS00085	COG0488	(ABC) transporter
CO997_RS00095	COG0028	Belongs to the TPP enzyme family
CO997_RS00170	COG2723	6-phospho-beta-galactosidase activity
CO997_RS00180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO997_RS00180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO997_RS00190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CO997_RS00190	COG0519	Catalyzes the synthesis of GMP from XMP
CO997_RS00195	COG1072	(Pantothenic acid kinase))
CO997_RS00200	COG2813	Specifically methylates the guanine in position
CO997_RS00205	COG1609	Transcriptional regulator
CO997_RS00210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CO997_RS00215	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CO997_RS00220	COG0295	cytidine deaminase activity
CO997_RS00225	COG1744	ABC transporter substrate-binding protein PnrA-like
CO997_RS00230	COG3845	ABC transporter
CO997_RS00235	COG4603	Belongs to the binding-protein-dependent transport system permease family
CO997_RS00240	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO997_RS00245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CO997_RS00255	COG0813	purine-nucleoside phosphorylase activity
CO997_RS00265	COG0588	phosphoglycerate mutase activity
CO997_RS00275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CO997_RS00280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CO997_RS00285	COG0049	tRNA binding
CO997_RS00290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO997_RS00295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO997_RS00300	COG0051	transcription antitermination factor activity, RNA binding
CO997_RS00305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CO997_RS00310	COG0088	Forms part of the polypeptide exit tunnel
CO997_RS00315	COG0089	rRNA binding
CO997_RS00320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO997_RS00330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CO997_RS00335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CO997_RS00340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CO997_RS00345	COG0255	Belongs to the universal ribosomal protein uL29 family
CO997_RS00350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CO997_RS00355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CO997_RS00360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CO997_RS00365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO997_RS00370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO997_RS00375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CO997_RS00380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CO997_RS00385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CO997_RS00390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CO997_RS00395	COG1841	ribosomal large subunit assembly
CO997_RS00400	COG0200	Binds to the 23S rRNA
CO997_RS00405	COG0201	protein transport
CO997_RS00410	COG0563	adenylate kinase activity
CO997_RS00415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CO997_RS00420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CO997_RS00425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO997_RS00430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CO997_RS00435	COG0202	RNA polymerase activity
CO997_RS00440	COG0203	ribosomal protein L17
CO997_RS00445	COG1122	ATPase activity
CO997_RS00450	COG1122	ATPase activity
CO997_RS00460	COG0101	tRNA pseudouridine synthase activity
CO997_RS00485	COG3328	transposase activity
CO997_RS00515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CO997_RS00530	COG1461	Dihydroxyacetone kinase
CO997_RS00535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CO997_RS00540	COG0416	fatty acid biosynthetic process
CO997_RS00545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO997_RS00555	COG4608	Belongs to the ABC transporter superfamily
CO997_RS00560	COG0601	transmembrane transport
CO997_RS00580	COG0571	ribonuclease III activity
CO997_RS00585	COG1196	nuclear chromosome segregation
CO997_RS00590	COG0561	phosphatase activity
CO997_RS00595	COG0552	protein localization to endoplasmic reticulum
CO997_RS00600	COG2918	glutathione biosynthetic process
CO997_RS00600	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO997_RS00605	COG2826	transposase and inactivated derivatives, IS30 family
CO997_RS00615	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO997_RS00620	COG4605	iron ion homeostasis
CO997_RS00625	COG4604	ABC transporter, ATP-binding protein
CO997_RS00630	COG4607	ABC-type enterochelin transport system periplasmic component
CO997_RS00665	COG1380	Effector of murein hydrolase LrgA
CO997_RS00685	COG1028	Short-chain dehydrogenase reductase Sdr
CO997_RS00695	COG1268	BioY protein
CO997_RS00700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CO997_RS00715	COG0561	phosphatase activity
CO997_RS00725	COG1692	metallophosphoesterase
CO997_RS00735	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO997_RS00745	COG0424	maF-like protein
CO997_RS00765	COG4372	Transposase
CO997_RS00770	COG1263	PTS System
CO997_RS00770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS00775	COG2188	Transcriptional regulator
CO997_RS00785	COG0632	four-way junction helicase activity
CO997_RS00790	COG2255	four-way junction helicase activity
CO997_RS00800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CO997_RS00810	COG1114	Component of the transport system for branched-chain amino acids
CO997_RS00820	COG1113	amino acid transport
CO997_RS00825	COG1126	abc transporter atp-binding protein
CO997_RS00830	COG0765	amino acid transport
CO997_RS00845	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CO997_RS00850	COG0110	maltose O-acetyltransferase activity
CO997_RS00855	COG1827	regulation of RNA biosynthetic process
CO997_RS00865	COG0242	peptide deformylase activity
CO997_RS00870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CO997_RS00875	COG1185	polyribonucleotide nucleotidyltransferase activity
CO997_RS00890	COG3158	transport of potassium into the cell
CO997_RS00895	COG1253	flavin adenine dinucleotide binding
CO997_RS00915	COG0534	Mate efflux family protein
CO997_RS00925	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CO997_RS00930	COG1187	pseudouridine synthase activity
CO997_RS00935	COG1011	Hydrolase
CO997_RS00940	COG0572	uridine kinase
CO997_RS00970	COG1671	Belongs to the UPF0178 family
CO997_RS00980	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO997_RS00985	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO997_RS00995	COG0736	holo-[acyl-carrier-protein] synthase activity
CO997_RS01000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CO997_RS01005	COG2337	Toxic component of a toxin-antitoxin (TA) module
CO997_RS01015	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO997_RS01020	COG0604	alcohol dehydrogenase
CO997_RS01020	COG3321	synthase
CO997_RS01050	COG0531	amino acid
CO997_RS01080	COG1174	glycine betaine transport
CO997_RS01100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CO997_RS01140	COG0343	queuine tRNA-ribosyltransferase activity
CO997_RS01145	COG1862	Preprotein translocase
CO997_RS01155	COG1454	alcohol dehydrogenase
CO997_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
CO997_RS01195	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CO997_RS01200	COG1028	Short-chain dehydrogenase reductase Sdr
CO997_RS01205	COG1304	FMN binding
CO997_RS01220	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CO997_RS01225	COG1428	Deoxynucleoside kinase
CO997_RS01240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CO997_RS01245	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CO997_RS01250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CO997_RS01285	COG0824	Thioesterase
CO997_RS01290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CO997_RS01320	COG1363	Peptidase, m42
CO997_RS01325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO997_RS01330	COG0589	response to stress
CO997_RS01340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO997_RS01345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO997_RS01350	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CO997_RS01380	COG3344	reverse transcriptase
CO997_RS01395	COG2946	Replication initiation factor
CO997_RS01440	COG0741	lytic transglycosylase activity
CO997_RS01440	COG0791	NLP P60 protein
CO997_RS01495	COG3328	transposase activity
CO997_RS01510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS01515	COG3414	Phosphotransferase system galactitol-specific IIB component
CO997_RS01520	COG3775	system Galactitol-specific IIC component
CO997_RS01545	COG1105	Belongs to the carbohydrate kinase PfkB family
CO997_RS01550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO997_RS01550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO997_RS01550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS01555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO997_RS01555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO997_RS01555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS01560	COG3684	Belongs to the aldolase LacD family
CO997_RS01575	COG2188	Transcriptional regulator
CO997_RS01585	COG4807	Protein conserved in bacteria
CO997_RS01595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CO997_RS01610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO997_RS01675	COG1368	sulfuric ester hydrolase activity
CO997_RS01685	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CO997_RS01695	COG0101	tRNA pseudouridine synthase activity
CO997_RS01715	COG3328	transposase activity
CO997_RS01735	COG0667	Aldo Keto reductase
CO997_RS01740	COG2186	Transcriptional regulator
CO997_RS01745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO997_RS01750	COG2723	6-phospho-beta-galactosidase activity
CO997_RS01760	COG1447	Phosphotransferase system cellobiose-specific component IIA
CO997_RS01780	COG1063	alcohol dehydrogenase
CO997_RS01790	COG4716	Myosin-crossreactive antigen
CO997_RS01830	COG1113	amino acid transport
CO997_RS01860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CO997_RS01870	COG3052	prosthetic group binding
CO997_RS01945	COG1051	belongs to the nudix hydrolase family
CO997_RS01950	COG1846	Transcriptional regulator
CO997_RS01975	COG2252	PERMEase
CO997_RS01980	COG0366	Alpha amylase catalytic
CO997_RS01985	COG2723	6-phospho-beta-galactosidase activity
CO997_RS01995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS01995	COG2190	(PTS) system
CO997_RS01995	COG1263	PTS System
CO997_RS02000	COG2723	6-phospho-beta-galactosidase activity
CO997_RS02015	COG1902	pentaerythritol trinitrate reductase activity
CO997_RS02025	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO997_RS02035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CO997_RS02040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CO997_RS02045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO997_RS02050	COG1193	negative regulation of DNA recombination
CO997_RS02055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CO997_RS02085	COG1937	Protein conserved in bacteria
CO997_RS02090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO997_RS02095	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO997_RS02125	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CO997_RS02130	COG2376	Dihydroxyacetone kinase
CO997_RS02135	COG1461	Dihydroxyacetone kinase
CO997_RS02150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO997_RS02160	COG1131	(ABC) transporter
CO997_RS02165	COG1309	transcriptional regulator
CO997_RS02170	COG3344	reverse transcriptase
CO997_RS02190	COG0531	amino acid
CO997_RS02195	COG1757	Na H antiporter
CO997_RS02200	COG1609	Transcriptional regulator
CO997_RS02210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO997_RS02220	COG1263	PTS System
CO997_RS02220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS02220	COG2190	(PTS) system
CO997_RS02250	COG3479	Phenolic acid decarboxylase
CO997_RS02255	COG1695	Transcriptional regulator
CO997_RS02265	COG2814	Major facilitator Superfamily
CO997_RS02295	COG0163	prenyltransferase activity
CO997_RS02300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CO997_RS02310	COG0577	efflux transmembrane transporter activity
CO997_RS02310	COG1136	(ABC) transporter
CO997_RS02325	COG0583	DNA-binding transcription factor activity
CO997_RS02330	COG1811	Na channel or pump
CO997_RS02365	COG1136	(ABC) transporter
CO997_RS02380	COG3942	CHAP domain
CO997_RS02380	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO997_RS02385	COG2190	(PTS) system
CO997_RS02385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS02385	COG1263	PTS System
CO997_RS02390	COG1869	D-ribose catabolic process
CO997_RS02400	COG1609	Transcriptional regulator
CO997_RS02425	COG0366	Alpha amylase catalytic
CO997_RS02435	COG0628	permease
CO997_RS02440	COG3443	Belongs to the bacterial solute-binding protein 9 family
CO997_RS02440	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO997_RS02465	COG1428	Deoxynucleoside kinase
CO997_RS02480	COG0210	DNA helicase
CO997_RS02485	COG1393	Belongs to the ArsC family
CO997_RS02490	COG1393	Belongs to the ArsC family
CO997_RS02520	COG0386	Belongs to the glutathione peroxidase family
CO997_RS02525	COG1854	S-ribosylhomocysteine lyase activity
CO997_RS02530	COG0626	cystathionine gamma-synthase activity
CO997_RS02535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CO997_RS02550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CO997_RS02555	COG0019	diaminopimelate decarboxylase activity
CO997_RS02560	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CO997_RS02570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CO997_RS02575	COG2171	N-acyltransferase activity
CO997_RS02580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CO997_RS02585	COG0527	aspartate kinase activity
CO997_RS02590	COG1473	amidohydrolase
CO997_RS02595	COG0436	Aminotransferase
CO997_RS02600	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO997_RS02620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO997_RS02625	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CO997_RS02640	COG2207	Transcriptional regulator
CO997_RS02645	COG2249	NAD(P)H dehydrogenase (quinone) activity
CO997_RS02655	COG1113	amino acid transport
CO997_RS02660	COG1121	(ABC) transporter
CO997_RS02665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO997_RS02680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CO997_RS02685	COG2823	Periplasmic or secreted lipoprotein
CO997_RS02685	COG1652	LysM domain
CO997_RS02695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO997_RS02700	COG0477	Major facilitator Superfamily
CO997_RS02710	COG1438	arginine binding
CO997_RS02725	COG1764	response to oxidative stress
CO997_RS02730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO997_RS02735	COG1335	isochorismatase
CO997_RS02765	COG2135	peptidase activity
CO997_RS02810	COG3546	catalase activity
CO997_RS02820	COG1175	transmembrane transport
CO997_RS02825	COG0395	ABC-type sugar transport system, permease component
CO997_RS02865	COG0745	RESPONSE REGULATOR receiver
CO997_RS02870	COG2205	protein histidine kinase activity
CO997_RS02875	COG4975	Glucose uptake
CO997_RS02880	COG0531	amino acid
CO997_RS02885	COG3853	Toxic anion resistance protein (TelA)
CO997_RS02905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CO997_RS02910	COG1335	isochorismatase
CO997_RS02925	COG3590	peptidase
CO997_RS02935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO997_RS02940	COG1104	cysteine desulfurase activity
CO997_RS02960	COG0482	sulfurtransferase activity
CO997_RS02970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CO997_RS02975	COG2814	Major facilitator Superfamily
CO997_RS02995	COG0463	Glycosyl transferase, family 2
CO997_RS03000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CO997_RS03005	COG2855	membrane
CO997_RS03020	COG0583	DNA-binding transcription factor activity
CO997_RS03030	COG0772	Belongs to the SEDS family
CO997_RS03035	COG1393	Belongs to the ArsC family
CO997_RS03040	COG0509	glycine decarboxylation via glycine cleavage system
CO997_RS03045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO997_RS03050	COG2011	ABC-type metal ion transport system permease component
CO997_RS03055	COG1464	Belongs to the NlpA lipoprotein family
CO997_RS03065	COG0719	Fe-S assembly protein
CO997_RS03070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CO997_RS03080	COG0719	Fe-S assembly protein
CO997_RS03135	COG2190	(PTS) system
CO997_RS03135	COG1263	PTS System
CO997_RS03135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS03140	COG2723	6-phospho-beta-galactosidase activity
CO997_RS03145	COG3711	transcriptional antiterminator
CO997_RS03165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CO997_RS03190	COG1136	(ABC) transporter
CO997_RS03190	COG0577	efflux transmembrane transporter activity
CO997_RS03200	COG3328	transposase activity
CO997_RS03205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO997_RS03215	COG1597	lipid kinase activity
CO997_RS03250	COG1733	regulation of RNA biosynthetic process
CO997_RS03260	COG3764	Sortase (surface protein transpeptidase)
CO997_RS03265	COG3711	transcriptional antiterminator
CO997_RS03270	COG1263	PTS System
CO997_RS03270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS03270	COG2190	(PTS) system
CO997_RS03275	COG2723	6-phospho-beta-galactosidase activity
CO997_RS03280	COG2188	Transcriptional regulator
CO997_RS03305	COG1611	Belongs to the LOG family
CO997_RS03315	COG1428	Deoxynucleoside kinase
CO997_RS03330	COG2723	6-phospho-beta-galactosidase activity
CO997_RS03350	COG1368	sulfuric ester hydrolase activity
CO997_RS03360	COG0105	UTP biosynthetic process
CO997_RS03365	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO997_RS03370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO997_RS03380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO997_RS03385	COG2011	ABC-type metal ion transport system permease component
CO997_RS03390	COG1464	Belongs to the NlpA lipoprotein family
CO997_RS03400	COG1757	Na H antiporter
CO997_RS03420	COG1113	amino acid transport
CO997_RS03430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CO997_RS03435	COG1929	Belongs to the glycerate kinase type-1 family
CO997_RS03440	COG0488	(ABC) transporter
CO997_RS03455	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CO997_RS03460	COG1263	PTS System
CO997_RS03460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS03475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CO997_RS03480	COG1131	(ABC) transporter
CO997_RS03500	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CO997_RS03515	COG0346	lactoylglutathione lyase activity
CO997_RS03540	COG0561	phosphatase activity
CO997_RS03545	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CO997_RS03550	COG0280	phosphate acetyltransferase
CO997_RS03555	COG0802	atpase or kinase
CO997_RS03560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO997_RS03585	COG0708	Exodeoxyribonuclease III
CO997_RS03595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CO997_RS03620	COG1053	succinate dehydrogenase
CO997_RS03630	COG1028	Short-chain dehydrogenase reductase Sdr
CO997_RS03630	COG3321	synthase
CO997_RS03630	COG0604	alcohol dehydrogenase
CO997_RS03635	COG0702	epimerase
CO997_RS03640	COG4684	Psort location CytoplasmicMembrane, score
CO997_RS03645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO997_RS03650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO997_RS03655	COG0604	alcohol dehydrogenase
CO997_RS03665	COG3842	ATPase activity
CO997_RS03670	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO997_RS03675	COG1177	transmembrane transport
CO997_RS03680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CO997_RS03685	COG3829	transcription factor binding
CO997_RS03700	COG3715	PTS system
CO997_RS03705	COG3716	PTS system mannose fructose sorbose family IID component
CO997_RS03720	COG1940	carbohydrate kinase activity
CO997_RS03760	COG0582	viral genome integration into host DNA
CO997_RS03770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO997_RS03780	COG0789	Transcriptional regulator
CO997_RS03800	COG0504	CTP synthase activity
CO997_RS03815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO997_RS03820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CO997_RS03825	COG0254	rRNA binding
CO997_RS03850	COG1349	DNA-binding transcription factor activity
CO997_RS03860	COG2814	Major facilitator Superfamily
CO997_RS03870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO997_RS03890	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CO997_RS03895	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CO997_RS03900	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CO997_RS03905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CO997_RS03910	COG3870	Protein conserved in bacteria
CO997_RS03915	COG0470	DNA polymerase III
CO997_RS03920	COG1774	PSP1 C-terminal conserved region
CO997_RS03925	COG4467	Involved in initiation control of chromosome replication
CO997_RS03940	COG0602	queuosine metabolic process
CO997_RS03945	COG1328	CTP reductase activity
CO997_RS03950	COG1136	(ABC) transporter
CO997_RS03955	COG0577	efflux transmembrane transporter activity
CO997_RS03970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CO997_RS03975	COG1696	Membrane protein involved in D-alanine export
CO997_RS03980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO997_RS03985	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CO997_RS03990	COG1363	Peptidase, m42
CO997_RS04000	COG1234	tRNA 3'-trailer cleavage
CO997_RS04005	COG0095	Lipoate-protein ligase
CO997_RS04040	COG3759	membrane
CO997_RS04045	COG0659	secondary active sulfate transmembrane transporter activity
CO997_RS04055	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CO997_RS04065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CO997_RS04070	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CO997_RS04070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CO997_RS04075	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS04075	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS04085	COG3715	PTS system
CO997_RS04090	COG3716	PTS system mannose fructose sorbose family IID component
CO997_RS04100	COG2261	transglycosylase associated protein
CO997_RS04105	COG0006	proline dipeptidase activity
CO997_RS04110	COG1302	Protein conserved in bacteria
CO997_RS04115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO997_RS04125	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO997_RS04130	COG1570	exodeoxyribonuclease VII activity
CO997_RS04135	COG1722	exodeoxyribonuclease VII activity
CO997_RS04145	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CO997_RS04150	COG1438	arginine binding
CO997_RS04155	COG0497	DNA recombination
CO997_RS04190	COG0768	penicillin binding
CO997_RS04225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CO997_RS04230	COG1799	cell septum assembly
CO997_RS04240	COG2302	S4 RNA-binding domain
CO997_RS04245	COG3599	regulation of cell shape
CO997_RS04250	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CO997_RS04255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CO997_RS04275	COG0673	inositol 2-dehydrogenase activity
CO997_RS04280	COG0513	Belongs to the DEAD box helicase family
CO997_RS04285	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CO997_RS04285	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CO997_RS04290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO997_RS04295	COG1447	Phosphotransferase system cellobiose-specific component IIA
CO997_RS04300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO997_RS04355	COG1396	sequence-specific DNA binding
CO997_RS04500	COG0740	serine-type endopeptidase activity
CO997_RS04615	COG3328	transposase activity
CO997_RS04650	COG2309	aminopeptidase activity
CO997_RS04660	COG0716	FMN binding
CO997_RS04665	COG0024	Methionine aminopeptidase
CO997_RS04670	COG1295	ribonuclease BN
CO997_RS04675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO997_RS04690	COG1215	transferase activity, transferring glycosyl groups
CO997_RS04695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CO997_RS04705	COG1088	dTDP-glucose 4,6-dehydratase activity
CO997_RS04710	COG1091	dTDP-4-dehydrorhamnose reductase activity
CO997_RS04735	COG4372	Transposase
CO997_RS04755	COG1682	transport, permease protein
CO997_RS04765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO997_RS04770	COG0438	transferase activity, transferring glycosyl groups
CO997_RS04770	COG1216	Glycosyl transferase, family 2
CO997_RS04775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CO997_RS04780	COG1216	Glycosyl transferase, family 2
CO997_RS04785	COG1215	transferase activity, transferring glycosyl groups
CO997_RS04790	COG1442	glycosyl transferase family 8
CO997_RS04790	COG1216	Glycosyl transferase, family 2
CO997_RS04795	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CO997_RS04795	COG0463	Glycosyl transferase, family 2
CO997_RS04810	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CO997_RS04830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CO997_RS04835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO997_RS04845	COG4585	Histidine kinase
CO997_RS04855	COG0569	domain protein
CO997_RS04885	COG2246	polysaccharide biosynthetic process
CO997_RS04890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CO997_RS04900	COG1316	TRANSCRIPTIONal
CO997_RS04905	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CO997_RS04910	COG3397	chitin binding
CO997_RS04915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO997_RS04920	COG2137	regulation of response to DNA damage stimulus
CO997_RS04925	COG1194	a g-specific adenine glycosylase
CO997_RS04930	COG3557	Belongs to the UPF0374 family
CO997_RS04940	COG0628	permease
CO997_RS04945	COG1253	flavin adenine dinucleotide binding
CO997_RS04955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CO997_RS04970	COG0542	response to heat
CO997_RS04975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS04980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CO997_RS04990	COG0438	transferase activity, transferring glycosyl groups
CO997_RS04995	COG2084	Dehydrogenase
CO997_RS05000	COG4703	Protein of unknown function (DUF1797)
CO997_RS05005	COG0322	excinuclease ABC activity
CO997_RS05010	COG1846	Transcriptional regulator
CO997_RS05015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO997_RS05025	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CO997_RS05035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO997_RS05045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO997_RS05050	COG0439	Biotin carboxylase
CO997_RS05055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CO997_RS05060	COG0825	malonyl-CoA metabolic process
CO997_RS05065	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CO997_RS05070	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO997_RS05075	COG1534	Rna-binding protein
CO997_RS05080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CO997_RS05085	COG1713	HD superfamily hydrolase involved in NAD metabolism
CO997_RS05090	COG0799	negative regulation of ribosome biogenesis
CO997_RS05095	COG2226	methyltransferase
CO997_RS05100	COG1323	Belongs to the UPF0348 family
CO997_RS05105	COG0217	transcriptional regulatory protein
CO997_RS05115	COG3973	AAA domain
CO997_RS05120	COG2217	Heavy metal translocating P-type atpase
CO997_RS05125	COG1942	4-Oxalocrotonate Tautomerase
CO997_RS05135	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO997_RS05140	COG1737	Transcriptional regulator
CO997_RS05145	COG0768	penicillin binding
CO997_RS05150	COG0561	phosphatase activity
CO997_RS05155	COG2252	PERMEase
CO997_RS05160	COG2814	Major facilitator Superfamily
CO997_RS05170	COG0587	DNA-directed DNA polymerase activity
CO997_RS05175	COG0205	6-phosphofructokinase activity
CO997_RS05185	COG0583	DNA-binding transcription factor activity
CO997_RS05195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CO997_RS05210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CO997_RS05215	COG0745	RESPONSE REGULATOR receiver
CO997_RS05220	COG5002	protein histidine kinase activity
CO997_RS05325	COG3711	transcriptional antiterminator
CO997_RS05335	COG1263	PTS System
CO997_RS05335	COG2190	(PTS) system
CO997_RS05335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS05340	COG1486	melibiose metabolic process
CO997_RS05345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS05345	COG1263	PTS System
CO997_RS05345	COG2190	(PTS) system
CO997_RS05350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO997_RS05375	COG1349	DNA-binding transcription factor activity
CO997_RS05400	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CO997_RS05405	COG3623	hexulose-6-phosphate isomerase
CO997_RS05415	COG0456	acetyltransferase
CO997_RS05440	COG3711	transcriptional antiterminator
CO997_RS05460	COG3775	system Galactitol-specific IIC component
CO997_RS05475	COG0400	carboxylic ester hydrolase activity
CO997_RS05480	COG0346	lactoylglutathione lyase activity
CO997_RS05490	COG2188	Transcriptional regulator
CO997_RS05495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO997_RS05500	COG2723	6-phospho-beta-galactosidase activity
CO997_RS05505	COG0589	response to stress
CO997_RS05520	COG1393	Belongs to the ArsC family
CO997_RS05530	COG0351	phosphomethylpyrimidine kinase
CO997_RS05535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO997_RS05540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO997_RS05550	COG3425	synthase
CO997_RS05555	COG0183	Belongs to the thiolase family
CO997_RS05570	COG0656	L-ascorbic acid biosynthetic process
CO997_RS05590	COG0392	lysyltransferase activity
CO997_RS05590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CO997_RS05595	COG0596	Alpha beta hydrolase
CO997_RS05600	COG0741	lytic transglycosylase activity
CO997_RS05610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO997_RS05615	COG0358	DNA primase activity
CO997_RS05620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO997_RS05635	COG2996	Protein conserved in bacteria
CO997_RS05640	COG0735	belongs to the Fur family
CO997_RS05655	COG4974	Belongs to the 'phage' integrase family
CO997_RS05665	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CO997_RS05670	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CO997_RS05675	COG1187	pseudouridine synthase activity
CO997_RS05680	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CO997_RS05685	COG1288	antiporter activity
CO997_RS05690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO997_RS05710	COG0514	ATP-dependent DNA helicase (RecQ)
CO997_RS05720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CO997_RS05725	COG0539	negative regulation of cytoplasmic translation
CO997_RS05730	COG1160	GTP binding
CO997_RS05735	COG0776	regulation of translation
CO997_RS05755	COG0457	Tetratricopeptide repeat
CO997_RS05760	COG5582	Belongs to the UPF0302 family
CO997_RS05765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO997_RS05770	COG1694	Mazg nucleotide pyrophosphohydrolase
CO997_RS05775	COG0617	tRNA 3'-terminal CCA addition
CO997_RS05800	COG0025	NhaP-type Na H and K H
CO997_RS05805	COG0488	(ABC) transporter
CO997_RS05810	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CO997_RS05820	COG1272	protein, Hemolysin III
CO997_RS05825	COG1307	EDD domain protein, DegV family
CO997_RS05830	COG2755	lipolytic protein G-D-S-L family
CO997_RS05835	COG4698	Protein conserved in bacteria
CO997_RS05845	COG4479	Belongs to the UPF0346 family
CO997_RS05850	COG0681	Belongs to the peptidase S26 family
CO997_RS05865	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO997_RS05870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO997_RS05875	COG0758	DNA mediated transformation
CO997_RS05880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO997_RS05885	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CO997_RS05890	COG4974	Belongs to the 'phage' integrase family
CO997_RS05895	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CO997_RS05900	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CO997_RS05920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CO997_RS05925	COG1832	CoA-binding protein
CO997_RS05930	COG0187	DNA topoisomerase II activity
CO997_RS05940	COG1882	Formate acetyltransferase
CO997_RS05945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CO997_RS05950	COG1227	inorganic diphosphatase activity
CO997_RS05970	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CO997_RS05980	COG1073	alpha beta
CO997_RS05985	COG1609	Transcriptional regulator
CO997_RS05995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO997_RS06015	COG1732	Glycine betaine
CO997_RS06030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO997_RS06040	COG1116	anion transmembrane transporter activity
CO997_RS06045	COG0084	hydrolase, TatD family'
CO997_RS06050	COG3942	CHAP domain
CO997_RS06050	COG1388	LysM domain
CO997_RS06065	COG0346	lactoylglutathione lyase activity
CO997_RS06075	COG3328	transposase activity
CO997_RS06105	COG0436	Aminotransferase
CO997_RS06125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO997_RS06130	COG4565	transcriptional regulatory protein
CO997_RS06135	COG3290	protein histidine kinase activity
CO997_RS06140	COG3290	protein histidine kinase activity
CO997_RS06150	COG2268	Band 7 protein
CO997_RS06170	COG0673	inositol 2-dehydrogenase activity
CO997_RS06180	COG1876	peptidase activity
CO997_RS06185	COG1388	LysM domain
CO997_RS06185	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO997_RS06195	COG1653	transport
CO997_RS06200	COG1175	transmembrane transport
CO997_RS06205	COG0395	ABC-type sugar transport system, permease component
CO997_RS06215	COG0673	inositol 2-dehydrogenase activity
CO997_RS06220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO997_RS06225	COG2233	PERMEase
CO997_RS06235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CO997_RS06240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CO997_RS06245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CO997_RS06255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CO997_RS06260	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO997_RS06265	COG0047	phosphoribosylformylglycinamidine synthase activity
CO997_RS06270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO997_RS06280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CO997_RS06285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CO997_RS06290	COG0138	bifunctional purine biosynthesis protein purh
CO997_RS06295	COG0151	Belongs to the GarS family
CO997_RS06300	COG4989	oxidoreductase activity
CO997_RS06310	COG2972	Histidine kinase
CO997_RS06320	COG4213	ABC transporter substrate-binding protein
CO997_RS06330	COG4214	carbohydrate transport
CO997_RS06335	COG0516	GMP reductase activity
CO997_RS06345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO997_RS06360	COG0022	dehydrogenase e1 component
CO997_RS06375	COG4476	Belongs to the UPF0223 family
CO997_RS06380	COG0483	inositol monophosphate 1-phosphatase activity
CO997_RS06385	COG1217	gtp-binding protein TYPA
CO997_RS06390	COG0514	ATP-dependent DNA helicase (RecQ)
CO997_RS06395	COG4838	Belongs to the UPF0358 family
CO997_RS06400	COG0772	Belongs to the SEDS family
CO997_RS06405	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CO997_RS06420	COG4471	UPF0298 protein
CO997_RS06425	COG0742	ribosomal rna small subunit methyltransferase
CO997_RS06430	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CO997_RS06435	COG3480	Lon protease (S16) C-terminal proteolytic domain
CO997_RS06440	COG1555	photosystem II stabilization
CO997_RS06440	COG1596	polysaccharide export
CO997_RS06455	COG2131	deaminase
CO997_RS06460	COG0658	competence protein
CO997_RS06460	COG2333	competence protein COMEC
CO997_RS06465	COG1466	dna polymerase III delta subunit
CO997_RS06470	COG0268	Binds directly to 16S ribosomal RNA
CO997_RS06480	COG2707	UPF0756 membrane protein
CO997_RS06485	COG2217	Heavy metal translocating P-type atpase
CO997_RS06490	COG1968	undecaprenyl-diphosphatase activity
CO997_RS06510	COG1666	GTP binding
CO997_RS06515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO997_RS06520	COG2151	metal-sulfur cluster biosynthetic enzyme
CO997_RS06530	COG3328	transposase activity
CO997_RS06540	COG1388	LysM domain
CO997_RS06540	COG3942	CHAP domain
CO997_RS06595	COG4990	cell redox homeostasis
CO997_RS06615	COG3104	oligopeptide transport
CO997_RS06625	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CO997_RS06630	COG1074	ATP-dependent DNA helicase activity
CO997_RS06635	COG1733	regulation of RNA biosynthetic process
CO997_RS06640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CO997_RS06645	COG0072	phenylalanine-tRNA ligase activity
CO997_RS06645	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO997_RS06655	COG1126	abc transporter atp-binding protein
CO997_RS06660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO997_RS06665	COG0765	amino acid transport
CO997_RS06670	COG0765	amino acid transport
CO997_RS06675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CO997_RS06680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CO997_RS06690	COG0517	IMP dehydrogenase activity
CO997_RS06695	COG0668	transmembrane transport
CO997_RS06705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO997_RS06710	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CO997_RS06715	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO997_RS06745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO997_RS06755	COG1234	tRNA 3'-trailer cleavage
CO997_RS06760	COG0300	oxidoreductase activity
CO997_RS06765	COG5416	Lipopolysaccharide assembly protein A domain
CO997_RS06770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CO997_RS06770	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CO997_RS06775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO997_RS06790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CO997_RS06805	COG2826	transposase and inactivated derivatives, IS30 family
CO997_RS06810	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO997_RS06810	COG1388	LysM domain
CO997_RS06815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CO997_RS06820	COG0735	belongs to the Fur family
CO997_RS06825	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO997_RS06835	COG1846	Transcriptional regulator
CO997_RS06845	COG3935	DnaD domain protein
CO997_RS06850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CO997_RS06860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO997_RS06865	COG3331	DNA recombination
CO997_RS06870	COG4474	Belongs to the UPF0398 family
CO997_RS06875	COG3599	regulation of cell shape
CO997_RS06885	COG0116	Belongs to the methyltransferase superfamily
CO997_RS06890	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CO997_RS06895	COG1418	mRNA catabolic process
CO997_RS06910	COG0156	8-amino-7-oxononanoate synthase activity
CO997_RS06915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CO997_RS06920	COG0531	amino acid
CO997_RS06935	COG0513	Belongs to the DEAD box helicase family
CO997_RS06940	COG2153	protein acetylation
CO997_RS06950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO997_RS06955	COG4684	Psort location CytoplasmicMembrane, score
CO997_RS06965	COG0328	RNA-DNA hybrid ribonuclease activity
CO997_RS06975	COG1278	Cold shock
CO997_RS06980	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO997_RS06995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CO997_RS07000	COG0564	pseudouridine synthase activity
CO997_RS07010	COG2233	PERMEase
CO997_RS07015	COG0540	Belongs to the ATCase OTCase family
CO997_RS07020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CO997_RS07025	COG0505	Belongs to the CarA family
CO997_RS07030	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO997_RS07035	COG0543	2 iron, 2 sulfur cluster binding
CO997_RS07045	COG0284	orotidine-5'-phosphate decarboxylase activity
CO997_RS07075	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CO997_RS07090	COG4120	Belongs to the binding-protein-dependent transport system permease family
CO997_RS07100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CO997_RS07135	COG0039	L-malate dehydrogenase activity
CO997_RS07155	COG3037	sugar-specific permease SgaT UlaA
CO997_RS07165	COG3711	transcriptional antiterminator
CO997_RS07175	COG0673	inositol 2-dehydrogenase activity
CO997_RS07240	COG0745	RESPONSE REGULATOR receiver
CO997_RS07245	COG5002	protein histidine kinase activity
CO997_RS07250	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CO997_RS07275	COG0351	phosphomethylpyrimidine kinase
CO997_RS07285	COG4475	Protein of unknown function (DUF436)
CO997_RS07290	COG0366	Alpha amylase catalytic
CO997_RS07305	COG1307	EDD domain protein, DegV family
CO997_RS07310	COG2244	polysaccharide biosynthetic process
CO997_RS07365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CO997_RS07370	COG0194	GDP metabolic process
CO997_RS07390	COG0765	amino acid transport
CO997_RS07395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO997_RS07405	COG0167	dihydroorotate dehydrogenase activity
CO997_RS07415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CO997_RS07425	COG3833	ABC-type maltose transport systems, permease component
CO997_RS07430	COG1175	transmembrane transport
CO997_RS07435	COG2182	Extracellular solute-binding protein
CO997_RS07440	COG0366	Alpha amylase catalytic
CO997_RS07445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO997_RS07455	COG1764	response to oxidative stress
CO997_RS07460	COG1846	Transcriptional regulator
CO997_RS07465	COG0628	permease
CO997_RS07480	COG1312	Catalyzes the dehydration of D-mannonate
CO997_RS07485	COG0246	Mannitol dehydrogenase
CO997_RS07495	COG0450	alkyl hydroperoxide reductase
CO997_RS07540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO997_RS07555	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CO997_RS07595	COG2946	Replication initiation factor
CO997_RS07620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO997_RS07640	COG0004	ammonium transporteR
CO997_RS07650	COG2261	transglycosylase associated protein
CO997_RS07675	COG3655	Transcriptional regulator
CO997_RS07690	COG2261	transglycosylase associated protein
CO997_RS07710	COG1028	Short-chain dehydrogenase reductase Sdr
CO997_RS07725	COG1442	glycosyl transferase family 8
CO997_RS07730	COG1442	glycosyl transferase family 8
CO997_RS07735	COG0561	phosphatase activity
CO997_RS07760	COG1476	TRANSCRIPTIONal
CO997_RS07775	COG1278	Cold shock
CO997_RS07785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO997_RS07790	COG1312	Catalyzes the dehydration of D-mannonate
CO997_RS07810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS07815	COG3716	PTS system mannose fructose sorbose family IID component
CO997_RS07825	COG0371	Dehydrogenase
CO997_RS07840	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CO997_RS07845	COG1737	Transcriptional regulator
CO997_RS07845	COG0837	glucose binding
CO997_RS07855	COG2272	Belongs to the type-B carboxylesterase lipase family
CO997_RS07860	COG1073	alpha beta
CO997_RS07895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO997_RS07915	COG3732	PTS system glucitol sorbitol-specific
CO997_RS07920	COG3730	PTS system glucitol sorbitol-specific
CO997_RS07930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS07930	COG3711	transcriptional antiterminator
CO997_RS07970	COG3328	transposase activity
CO997_RS07980	COG4974	Belongs to the 'phage' integrase family
CO997_RS07985	COG0481	GTPase activity
CO997_RS08005	COG0542	response to heat
CO997_RS08020	COG1597	lipid kinase activity
CO997_RS08025	COG2195	Cleaves the N-terminal amino acid of tripeptides
CO997_RS08030	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CO997_RS08035	COG2384	SAM-dependent methyltransferase
CO997_RS08045	COG1484	DNA-dependent DNA replication
CO997_RS08055	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CO997_RS08065	COG0237	dephospho-CoA kinase activity
CO997_RS08070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CO997_RS08075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO997_RS08075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO997_RS08090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CO997_RS08095	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CO997_RS08100	COG3091	SprT-like family
CO997_RS08105	COG2183	response to ionizing radiation
CO997_RS08115	COG1054	Belongs to the UPF0176 family
CO997_RS08140	COG0546	phosphoglycolate phosphatase activity
CO997_RS08145	COG0588	phosphoglycerate mutase activity
CO997_RS08190	COG4753	response regulator
CO997_RS08190	COG2207	Transcriptional regulator
CO997_RS08200	COG2972	Histidine kinase
CO997_RS08205	COG0077	Prephenate dehydratase
CO997_RS08210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CO997_RS08215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CO997_RS08220	COG0287	Prephenate dehydrogenase
CO997_RS08225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CO997_RS08235	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CO997_RS08245	COG3250	beta-galactosidase activity
CO997_RS08260	COG1609	Transcriptional regulator
CO997_RS08270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO997_RS08280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO997_RS08285	COG1597	lipid kinase activity
CO997_RS08290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO997_RS08295	COG0154	amidase activity
CO997_RS08300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO997_RS08305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CO997_RS08310	COG0210	DNA helicase
CO997_RS08320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO997_RS08320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO997_RS08320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS08325	COG1105	Belongs to the carbohydrate kinase PfkB family
CO997_RS08330	COG1349	DNA-binding transcription factor activity
CO997_RS08350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CO997_RS08355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CO997_RS08360	COG0544	peptidyl-prolyl cis-trans isomerase activity
CO997_RS08370	COG1714	RDD family
CO997_RS08385	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO997_RS08390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO997_RS08460	COG1481	regulation of sporulation
CO997_RS08465	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CO997_RS08470	COG1660	Displays ATPase and GTPase activities
CO997_RS08485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO997_RS08490	COG0556	nucleotide-excision repair
CO997_RS08495	COG0765	amino acid transport
CO997_RS08500	COG1126	abc transporter atp-binding protein
CO997_RS08505	COG2508	Transcriptional regulator
CO997_RS08515	COG3328	transposase activity
CO997_RS08520	COG0484	heat shock protein binding
CO997_RS08525	COG0443	Heat shock 70 kDa protein
CO997_RS08530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO997_RS08535	COG1420	regulation of RNA biosynthetic process
CO997_RS08540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO997_RS08550	COG0693	protein deglycase activity
CO997_RS08560	COG1619	proteins homologs of microcin C7 resistance protein MccF
CO997_RS08570	COG5646	InterPro IPR014922
CO997_RS08580	COG4975	Glucose uptake
CO997_RS08590	COG0196	riboflavin kinase activity
CO997_RS08595	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CO997_RS08605	COG1175	transmembrane transport
CO997_RS08610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CO997_RS08625	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CO997_RS08630	COG0195	Participates in both transcription termination and antitermination
CO997_RS08635	COG0779	Required for maturation of 30S ribosomal subunits
CO997_RS08640	COG2176	DNA-directed DNA polymerase activity
CO997_RS08645	COG0442	prolyl-tRNA aminoacylation
CO997_RS08650	COG0750	zinc metalloprotease
CO997_RS08655	COG4589	Belongs to the CDS family
CO997_RS08660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CO997_RS08670	COG0233	cytoplasmic translational termination
CO997_RS08675	COG0528	UMP kinase activity
CO997_RS08680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CO997_RS08685	COG0052	Belongs to the universal ribosomal protein uS2 family
CO997_RS08690	COG1438	arginine binding
CO997_RS08710	COG0018	arginyl-trna synthetase
CO997_RS08725	COG2235	arginine
CO997_RS08730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO997_RS08740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CO997_RS08745	COG0456	acetyltransferase
CO997_RS08755	COG1214	PFAM Peptidase M22, glycoprotease
CO997_RS08760	COG1609	Transcriptional regulator
CO997_RS08765	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CO997_RS08770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO997_RS08785	COG3189	MarR family transcriptional regulator
CO997_RS08790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO997_RS08795	COG1940	carbohydrate kinase activity
CO997_RS08810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CO997_RS08815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO997_RS08820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO997_RS08825	COG1120	ATPase activity
CO997_RS08840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO997_RS08845	COG4876	unkown
CO997_RS08850	COG0367	asparagine synthase
CO997_RS08855	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CO997_RS09125	COG1396	sequence-specific DNA binding
CO997_RS09155	COG1309	transcriptional regulator
CO997_RS09175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CO997_RS09190	COG0584	glycerophosphoryl diester phosphodiesterase
CO997_RS09220	COG0166	Belongs to the GPI family
CO997_RS09225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CO997_RS09230	COG2081	HI0933 family
CO997_RS09235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CO997_RS09240	COG0710	3-dehydroquinate dehydratase activity
CO997_RS09245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CO997_RS09250	COG1368	sulfuric ester hydrolase activity
CO997_RS09270	COG3850	Histidine kinase
CO997_RS09270	COG5002	protein histidine kinase activity
CO997_RS09275	COG0745	RESPONSE REGULATOR receiver
CO997_RS09300	COG3328	transposase activity
CO997_RS09315	COG1956	GAF domain-containing protein
CO997_RS09320	COG3527	Alpha-acetolactate decarboxylase
CO997_RS09325	COG0028	Belongs to the TPP enzyme family
CO997_RS09335	COG0395	ABC-type sugar transport system, permease component
CO997_RS09345	COG0583	DNA-binding transcription factor activity
CO997_RS09350	COG0789	Transcriptional regulator
CO997_RS09355	COG2814	Major facilitator Superfamily
CO997_RS09425	COG0335	large ribosomal subunit rRNA binding
CO997_RS09430	COG0336	Belongs to the RNA methyltransferase TrmD family
CO997_RS09435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CO997_RS09445	COG1837	Belongs to the UPF0109 family
CO997_RS09450	COG0228	four-way junction DNA binding
CO997_RS09455	COG0431	NADPH-dependent FMN reductase
CO997_RS09460	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO997_RS09465	COG0519	Catalyzes the synthesis of GMP from XMP
CO997_RS09470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO997_RS09475	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CO997_RS09485	COG0745	RESPONSE REGULATOR receiver
CO997_RS09490	COG5002	protein histidine kinase activity
CO997_RS09495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO997_RS09510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CO997_RS09535	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CO997_RS09555	COG3328	transposase activity
CO997_RS09560	COG3328	transposase activity
CO997_RS09610	COG0714	Associated with various cellular activities
CO997_RS09635	COG2217	Heavy metal translocating P-type atpase
CO997_RS09640	COG2217	Heavy metal translocating P-type atpase
CO997_RS09645	COG2608	mercury ion transmembrane transporter activity
CO997_RS09650	COG3682	Transcriptional regulator
CO997_RS09660	COG0531	amino acid
CO997_RS09665	COG2217	Heavy metal translocating P-type atpase
CO997_RS09690	COG0017	Asparaginyl-tRNA synthetase
CO997_RS09695	COG0436	Aminotransferase
CO997_RS09705	COG1199	ATP-dependent helicase activity
CO997_RS09705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO997_RS09710	COG1278	Cold shock
CO997_RS09735	COG1686	Belongs to the peptidase S11 family
CO997_RS09745	COG0038	chloride channel
CO997_RS09765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO997_RS09770	COG1254	Belongs to the acylphosphatase family
CO997_RS09780	COG0706	membrane insertase activity
CO997_RS09785	COG3684	Belongs to the aldolase LacD family
CO997_RS09840	COG1216	Glycosyl transferase, family 2
CO997_RS09850	COG0438	transferase activity, transferring glycosyl groups
CO997_RS09870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CO997_RS09875	COG4464	protein tyrosine phosphatase activity
CO997_RS09880	COG0489	protein tyrosine kinase activity
CO997_RS09885	COG3944	biosynthesis protein
CO997_RS09890	COG1316	TRANSCRIPTIONal
CO997_RS09900	COG0751	glycine-tRNA ligase activity
CO997_RS09905	COG0752	glycyl-tRNA synthetase alpha subunit
CO997_RS09910	COG1381	Involved in DNA repair and RecF pathway recombination
CO997_RS09915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CO997_RS09920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CO997_RS09925	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CO997_RS09935	COG1702	phosphate starvation-inducible protein PhoH
CO997_RS09940	COG1114	Component of the transport system for branched-chain amino acids
CO997_RS09945	COG1610	YqeY-like protein
CO997_RS09950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CO997_RS09955	COG0735	belongs to the Fur family
CO997_RS09960	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CO997_RS09965	COG0640	Transcriptional regulator
CO997_RS09970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO997_RS09975	COG0492	ferredoxin-NADP+ reductase activity
CO997_RS09980	COG2723	6-phospho-beta-galactosidase activity
CO997_RS09985	COG1486	melibiose metabolic process
CO997_RS09995	COG1737	Transcriptional regulator
CO997_RS10000	COG1263	PTS System
CO997_RS10000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS10000	COG2190	(PTS) system
CO997_RS10010	COG1132	(ABC) transporter
CO997_RS10015	COG1132	(ABC) transporter
CO997_RS10020	COG3763	UPF0154 protein
CO997_RS10030	COG1914	H( )-stimulated, divalent metal cation uptake system
CO997_RS10040	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CO997_RS10050	COG3328	transposase activity
CO997_RS10085	COG1609	Transcriptional regulator
CO997_RS10095	COG4980	gas vesicle protein
CO997_RS10105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CO997_RS10110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CO997_RS10115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CO997_RS10120	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CO997_RS10125	COG1950	PFAM Membrane protein of
CO997_RS10155	COG0704	Plays a role in the regulation of phosphate uptake
CO997_RS10160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO997_RS10165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO997_RS10170	COG0581	inorganic phosphate transmembrane transporter activity
CO997_RS10175	COG0573	inorganic phosphate transmembrane transporter activity
CO997_RS10180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CO997_RS10185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO997_RS10190	COG2177	Part of the ABC transporter FtsEX involved in
CO997_RS10195	COG2884	Cell division ATP-binding protein ftsE
CO997_RS10205	COG0653	protein targeting
CO997_RS10220	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CO997_RS10225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO997_RS10235	COG1739	Uncharacterized protein family UPF0029
CO997_RS10240	COG2188	Transcriptional regulator
CO997_RS10260	COG1940	carbohydrate kinase activity
CO997_RS10280	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO997_RS10295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CO997_RS10300	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CO997_RS10305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CO997_RS10310	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CO997_RS10315	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO997_RS10320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO997_RS10325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO997_RS10330	COG0356	it plays a direct role in the translocation of protons across the membrane
CO997_RS10335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CO997_RS10340	COG0557	exoribonuclease II activity
CO997_RS10345	COG1647	Serine aminopeptidase, S33
CO997_RS10350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CO997_RS10355	COG2388	GCN5-related N-acetyl-transferase
CO997_RS10365	COG1957	nucleoside hydrolase
CO997_RS10375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO997_RS10385	COG0149	triose-phosphate isomerase activity
CO997_RS10390	COG0126	phosphoglycerate kinase activity
CO997_RS10400	COG2390	Transcriptional regulator
CO997_RS10405	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CO997_RS10425	COG1595	DNA-templated transcription, initiation
CO997_RS10445	COG0095	Lipoate-protein ligase
CO997_RS10450	COG1078	dGTPase activity
CO997_RS10455	COG0561	phosphatase activity
CO997_RS10460	COG0494	nUDIX hydrolase
CO997_RS10465	COG0346	lactoylglutathione lyase activity
CO997_RS10475	COG2423	ornithine cyclodeaminase activity
CO997_RS10480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO997_RS10485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO997_RS10490	COG1394	ATPase activity, coupled to movement of substances
CO997_RS10495	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CO997_RS10500	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CO997_RS10505	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CO997_RS10510	COG1527	subunit (C
CO997_RS10515	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CO997_RS10520	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO997_RS10525	COG1269	ATP hydrolysis coupled proton transport
CO997_RS10535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CO997_RS10540	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CO997_RS10550	COG4152	abc transporter atp-binding protein
CO997_RS10555	COG0322	excinuclease ABC activity
CO997_RS10560	COG3118	belongs to the thioredoxin family
CO997_RS10565	COG1193	negative regulation of DNA recombination
CO997_RS10580	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO997_RS10595	COG1136	(ABC) transporter
CO997_RS10605	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO997_RS10640	COG1304	FMN binding
CO997_RS10655	COG0281	malic enzyme
CO997_RS10680	COG3906	Belongs to the UPF0473 family
CO997_RS10685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CO997_RS10690	COG4472	Bacterial protein of unknown function (DUF965)
CO997_RS10720	COG4555	ABC transporter
CO997_RS10730	COG3689	TIGRFAM TIGR03943 family protein
CO997_RS10735	COG0701	Predicted permease
CO997_RS10740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO997_RS10745	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CO997_RS10750	COG0488	(ABC) transporter
CO997_RS10755	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CO997_RS10770	COG0395	ABC-type sugar transport system, permease component
CO997_RS10790	COG2207	Transcriptional regulator
CO997_RS10790	COG0662	Cupin 2, conserved barrel domain protein
CO997_RS10795	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO997_RS10805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CO997_RS10810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CO997_RS10815	COG0584	glycerophosphoryl diester phosphodiesterase
CO997_RS10825	COG0740	serine-type endopeptidase activity
CO997_RS10830	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CO997_RS10840	COG1132	(ABC) transporter
CO997_RS10850	COG5503	Protein of unknown function (DUF1447)
CO997_RS10865	COG1278	Cold shock
CO997_RS10895	COG3328	transposase activity
CO997_RS11100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO997_RS11110	COG3723	Recombinational DNA repair protein, rece pathway
CO997_RS11115	COG5377	YqaJ viral recombinase family
CO997_RS11155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CO997_RS11160	COG2003	Belongs to the UPF0758 family
CO997_RS11165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO997_RS11170	COG0285	dihydrofolate synthase activity
CO997_RS11175	COG0525	valine-tRNA ligase activity
CO997_RS11180	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CO997_RS11185	COG0301	tRNA thio-modification
CO997_RS11190	COG1104	cysteine desulfurase activity
CO997_RS11195	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CO997_RS11205	COG0561	phosphatase activity
CO997_RS11210	COG1801	Protein of unknown function DUF72
CO997_RS11230	COG3579	cysteine-type endopeptidase activity
CO997_RS11300	COG1098	S1 RNA binding domain
CO997_RS11305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CO997_RS11315	COG0492	ferredoxin-NADP+ reductase activity
CO997_RS11320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CO997_RS11335	COG4470	Protein conserved in bacteria
CO997_RS11340	COG0737	Belongs to the 5'-nucleotidase family
CO997_RS11355	COG0590	tRNA wobble adenosine to inosine editing
CO997_RS11360	COG2508	Transcriptional regulator
CO997_RS11370	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CO997_RS11370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO997_RS11385	COG2738	Putative neutral zinc metallopeptidase
CO997_RS11390	COG2824	Alkylphosphonate utilization operon protein PhnA
CO997_RS11395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CO997_RS11400	COG4109	DRTGG domain
CO997_RS11405	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CO997_RS11425	COG0577	efflux transmembrane transporter activity
CO997_RS11430	COG1136	(ABC) transporter
CO997_RS11440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CO997_RS11445	COG1288	antiporter activity
CO997_RS11455	COG4821	SIS domain
CO997_RS11475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CO997_RS11480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CO997_RS11485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO997_RS11490	COG3716	PTS system mannose fructose sorbose family IID component
CO997_RS11495	COG3715	PTS system
CO997_RS11520	COG1132	(ABC) transporter
CO997_RS11525	COG1132	(ABC) transporter
CO997_RS11540	COG1803	Methylglyoxal synthase
CO997_RS11545	COG3842	ATPase activity
CO997_RS11555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO997_RS11560	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CO997_RS11565	COG0084	hydrolase, TatD family'
CO997_RS11570	COG0531	amino acid
CO997_RS11580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO997_RS11580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO997_RS11600	COG0675	Transposase, IS605 OrfB family
CO997_RS11605	COG4608	Belongs to the ABC transporter superfamily
CO997_RS11610	COG0444	Belongs to the ABC transporter superfamily
CO997_RS11615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO997_RS11620	COG0601	transmembrane transport
CO997_RS11630	COG4166	transmembrane transport
CO997_RS11655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CO997_RS11660	COG1674	ftsk spoiiie
CO997_RS11660	COG1280	lysine exporter protein (LysE YggA)
CO997_RS11665	COG2723	6-phospho-beta-galactosidase activity
CO997_RS11675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO997_RS11680	COG1126	abc transporter atp-binding protein
CO997_RS11685	COG0765	amino acid transport
CO997_RS11725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CO997_RS11735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO997_RS11740	COG0009	L-threonylcarbamoyladenylate synthase
CO997_RS11750	COG2890	protein-(glutamine-N5) methyltransferase activity
CO997_RS11755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CO997_RS11760	COG1435	thymidine kinase activity
CO997_RS11770	COG2226	methyltransferase
CO997_RS11775	COG0681	Belongs to the peptidase S26 family
CO997_RS11800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO997_RS11805	COG3442	glutamine amidotransferase
CO997_RS11820	COG0246	Mannitol dehydrogenase
CO997_RS11825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS11830	COG2213	PTS system mannitol-specific
CO997_RS11835	COG1131	(ABC) transporter
CO997_RS11845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS11850	COG3711	transcriptional antiterminator
CO997_RS11855	COG2213	PTS system mannitol-specific
CO997_RS11860	COG1482	cell wall glycoprotein biosynthetic process
CO997_RS11880	COG1132	(ABC) transporter
CO997_RS11900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CO997_RS11905	COG0628	permease
CO997_RS11915	COG2706	6-phosphogluconolactonase activity
CO997_RS11925	COG1368	sulfuric ester hydrolase activity
CO997_RS11935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO997_RS11940	COG2160	L-arabinose isomerase activity
CO997_RS11945	COG0235	Class ii aldolase
CO997_RS11965	COG3940	Belongs to the glycosyl hydrolase 43 family
CO997_RS11970	COG3534	alpha-L-arabinofuranosidase
CO997_RS11980	COG0395	ABC-type sugar transport system, permease component
CO997_RS11985	COG1175	transmembrane transport
CO997_RS12005	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CO997_RS12010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CO997_RS12015	COG3328	transposase activity
CO997_RS12030	COG0789	Transcriptional regulator
CO997_RS12035	COG1609	Transcriptional regulator
CO997_RS12045	COG0459	protein refolding
CO997_RS12050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CO997_RS12060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO997_RS12065	COG2910	NAD(P)H-binding
CO997_RS12070	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CO997_RS12085	COG5002	protein histidine kinase activity
CO997_RS12090	COG0745	RESPONSE REGULATOR receiver
CO997_RS12095	COG1307	EDD domain protein, DegV family
CO997_RS12115	COG1714	RDD family
CO997_RS12150	COG3279	Response regulator of the LytR AlgR family
CO997_RS12190	COG3328	transposase activity
CO997_RS12215	COG4175	Glycine betaine
CO997_RS12215	COG3448	diguanylate cyclase activity
CO997_RS12245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CO997_RS12250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO997_RS12260	COG0628	permease
CO997_RS12265	COG1285	pathogenesis
CO997_RS12270	COG0363	glucosamine-6-phosphate deaminase activity
CO997_RS12275	COG0488	(ABC) transporter
CO997_RS12280	COG2814	Major facilitator Superfamily
CO997_RS12290	COG0222	ribosome binding
CO997_RS12295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CO997_RS12300	COG0081	regulation of translation
CO997_RS12305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CO997_RS12310	COG1760	l-serine dehydratase
CO997_RS12315	COG1760	l-serine dehydratase
CO997_RS12320	COG1304	FMN binding
CO997_RS12325	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CO997_RS12330	COG0250	Participates in transcription elongation, termination and antitermination
CO997_RS12335	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CO997_RS12340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO997_RS12355	COG1597	lipid kinase activity
CO997_RS12375	COG4585	Histidine kinase
CO997_RS12380	COG2197	response regulator
CO997_RS12390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO997_RS12400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CO997_RS12405	COG2226	methyltransferase
CO997_RS12410	COG3142	Participates in the control of copper homeostasis
CO997_RS12415	COG2239	Acts as a magnesium transporter
CO997_RS12420	COG0564	pseudouridine synthase activity
CO997_RS12425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CO997_RS12430	COG2357	RelA SpoT domain protein
CO997_RS12435	COG4116	CYTH
CO997_RS12455	COG4862	establishment of competence for transformation
CO997_RS12465	COG1393	Belongs to the ArsC family
CO997_RS12480	COG0419	ATPase involved in DNA repair
CO997_RS12485	COG0420	3'-5' exonuclease activity
CO997_RS12490	COG0204	Acyl-transferase
CO997_RS12495	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CO997_RS12500	COG2827	Endonuclease containing a URI domain
CO997_RS12505	COG2755	lipolytic protein G-D-S-L family
CO997_RS12505	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CO997_RS12510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO997_RS12515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CO997_RS12520	COG0124	histidyl-tRNA synthetase
CO997_RS12530	COG0667	Aldo Keto reductase
CO997_RS12535	COG2124	cytochrome p450
CO997_RS12540	COG1490	D-aminoacyl-tRNA deacylase activity
CO997_RS12545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CO997_RS12555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CO997_RS12560	COG2264	protein methyltransferase activity
CO997_RS12570	COG2094	Belongs to the DNA glycosylase MPG family
CO997_RS12575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CO997_RS12590	COG0589	response to stress
CO997_RS12600	COG0488	(ABC) transporter
CO997_RS12605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CO997_RS12610	COG0827	DNA restriction-modification system
CO997_RS12635	COG4537	Required for transformation and DNA binding
CO997_RS12640	COG1459	type II secretion system
CO997_RS12645	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CO997_RS12650	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CO997_RS12655	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CO997_RS12665	COG4473	ABC transporter
CO997_RS12670	COG1131	(ABC) transporter
CO997_RS12675	COG0537	adenosine 5'-monophosphoramidase activity
CO997_RS12685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO997_RS12690	COG3481	metal-dependent phosphohydrolase, HD sub domain
CO997_RS12695	COG4717	serine-type aminopeptidase activity
CO997_RS12700	COG0420	3'-5' exonuclease activity
CO997_RS12710	COG0561	phosphatase activity
CO997_RS12745	COG2211	Major facilitator Superfamily
CO997_RS12755	COG3507	Belongs to the glycosyl hydrolase 43 family
CO997_RS12770	COG1073	alpha beta
CO997_RS12780	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CO997_RS12785	COG1653	transport
CO997_RS12795	COG4209	transmembrane transport
CO997_RS12800	COG0395	ABC-type sugar transport system, permease component
CO997_RS12810	COG2207	Transcriptional regulator
CO997_RS12815	COG1609	Transcriptional regulator
CO997_RS12820	COG0246	Mannitol dehydrogenase
CO997_RS12825	COG2721	sulfolactate sulfo-lyase activity
CO997_RS12830	COG1904	glucuronate isomerase
CO997_RS12845	COG2755	lipolytic protein G-D-S-L family
CO997_RS12855	COG1132	(ABC) transporter
CO997_RS12860	COG3679	Belongs to the UPF0342 family
CO997_RS12865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO997_RS12870	COG0564	pseudouridine synthase activity
CO997_RS12875	COG1940	carbohydrate kinase activity
CO997_RS12880	COG0383	alpha-mannosidase activity
CO997_RS12905	COG2207	Transcriptional regulator
CO997_RS12905	COG4753	response regulator
CO997_RS12910	COG2972	Histidine kinase
CO997_RS12925	COG1653	transport
CO997_RS12930	COG0395	ABC-type sugar transport system, permease component
CO997_RS12935	COG1175	transmembrane transport
CO997_RS12945	COG1187	pseudouridine synthase activity
CO997_RS12950	COG2244	polysaccharide biosynthetic process
CO997_RS12960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CO997_RS12965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO997_RS12980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS12980	COG3711	transcriptional antiterminator
CO997_RS13020	COG0789	Transcriptional regulator
CO997_RS13020	COG4978	Transcriptional regulator
CO997_RS13030	COG1132	(ABC) transporter
CO997_RS13045	COG0495	leucyl-tRNA aminoacylation
CO997_RS13050	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO997_RS13050	COG1388	LysM domain
CO997_RS13055	COG0671	phosphoesterase, PA-phosphatase related
CO997_RS13060	COG1242	4 iron, 4 sulfur cluster binding
CO997_RS13065	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CO997_RS13070	COG3328	transposase activity
CO997_RS13115	COG0582	viral genome integration into host DNA
CO997_RS13120	COG3328	transposase activity
CO997_RS13135	COG1132	(ABC) transporter
CO997_RS13140	COG1132	(ABC) transporter
CO997_RS13155	COG0477	Major facilitator Superfamily
CO997_RS13160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CO997_RS13320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CO997_RS13325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO997_RS13330	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CO997_RS13340	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CO997_RS13345	COG0037	tRNA processing
CO997_RS13350	COG1098	S1 RNA binding domain
CO997_RS13360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CO997_RS13365	COG2244	polysaccharide biosynthetic process
CO997_RS13370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CO997_RS13375	COG0193	aminoacyl-tRNA hydrolase activity
CO997_RS13380	COG0039	L-malate dehydrogenase activity
CO997_RS13390	COG0217	transcriptional regulatory protein
CO997_RS13435	COG1792	Involved in formation and maintenance of cell shape
CO997_RS13445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CO997_RS13450	COG1162	GTPase activity
CO997_RS13455	COG0515	serine threonine protein kinase
CO997_RS13455	COG2815	serine threonine protein kinase
CO997_RS13460	COG0631	protein serine/threonine phosphatase activity
CO997_RS13465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO997_RS13465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO997_RS13470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO997_RS13475	COG0242	peptide deformylase activity
CO997_RS13480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CO997_RS13485	COG1758	RNA polymerase activity
CO997_RS13490	COG0194	GDP metabolic process
CO997_RS13500	COG1561	YicC-like family, N-terminal region
CO997_RS13510	COG1752	Esterase of the alpha-beta hydrolase superfamily
CO997_RS13525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO997_RS13530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO997_RS13535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO997_RS13540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO997_RS13545	COG1121	(ABC) transporter
CO997_RS13550	COG3443	Belongs to the bacterial solute-binding protein 9 family
CO997_RS13550	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO997_RS13555	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CO997_RS13560	COG0392	lysyltransferase activity
CO997_RS13560	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CO997_RS13565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CO997_RS13570	COG1418	mRNA catabolic process
CO997_RS13575	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CO997_RS13580	COG1546	Belongs to the CinA family
CO997_RS13580	COG1058	Belongs to the CinA family
CO997_RS13585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CO997_RS13595	COG1426	Protein conserved in bacteria
CO997_RS13600	COG0612	Peptidase, M16
CO997_RS13605	COG0612	Peptidase, M16
CO997_RS13610	COG1970	mechanosensitive ion channel activity
CO997_RS13615	COG2153	protein acetylation
CO997_RS13630	COG4466	Protein conserved in bacteria
CO997_RS13640	COG3688	RNA-binding protein containing a PIN domain
CO997_RS13645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO997_RS13650	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CO997_RS13655	COG0215	cysteine-tRNA ligase activity
CO997_RS13660	COG1045	serine acetyltransferase
CO997_RS13665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO997_RS13670	COG4956	integral membrane protein (PIN domain superfamily)
CO997_RS13680	COG0756	dUTP diphosphatase activity
CO997_RS13690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CO997_RS13695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CO997_RS13715	COG2814	Major facilitator Superfamily
CO997_RS13745	COG0778	Nitroreductase
CO997_RS13755	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO997_RS13755	COG1388	LysM domain
CO997_RS13760	COG4221	oxidoreductase activity
CO997_RS13770	COG0583	DNA-binding transcription factor activity
CO997_RS13775	COG3711	transcriptional antiterminator
CO997_RS13780	COG2190	(PTS) system
CO997_RS13780	COG1263	PTS System
CO997_RS13780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS13785	COG0702	epimerase
CO997_RS13800	COG2207	Transcriptional regulator
CO997_RS13800	COG3708	Transcriptional regulator
CO997_RS13815	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CO997_RS13825	COG0604	alcohol dehydrogenase
CO997_RS13840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO997_RS13850	COG0842	Transport permease protein
CO997_RS13855	COG1131	(ABC) transporter
CO997_RS13865	COG2205	protein histidine kinase activity
CO997_RS13870	COG0745	RESPONSE REGULATOR receiver
CO997_RS13910	COG1674	ftsk spoiiie
CO997_RS13920	COG3344	reverse transcriptase
CO997_RS13925	COG1674	ftsk spoiiie
CO997_RS13950	COG2946	Replication initiation factor
CO997_RS14000	COG0791	NLP P60 protein
CO997_RS14000	COG0741	lytic transglycosylase activity
CO997_RS14025	COG2814	Major facilitator Superfamily
CO997_RS14035	COG3942	CHAP domain
CO997_RS14035	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO997_RS14040	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO997_RS14055	COG3708	Transcriptional regulator
CO997_RS14055	COG2207	Transcriptional regulator
CO997_RS14100	COG0523	cobalamin synthesis protein
CO997_RS14150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO997_RS14160	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CO997_RS14165	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO997_RS14170	COG1132	(ABC) transporter
CO997_RS14175	COG1132	(ABC) transporter
CO997_RS14185	COG1129	ABC transporter
CO997_RS14195	COG1309	transcriptional regulator
CO997_RS14230	COG4974	Belongs to the 'phage' integrase family
CO997_RS14250	COG2188	Transcriptional regulator
CO997_RS14255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO997_RS14260	COG3716	PTS system mannose fructose sorbose family IID component
CO997_RS14265	COG3715	PTS system
CO997_RS14275	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO997_RS14280	COG2222	sugar isomerase
CO997_RS14295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS14295	COG1263	PTS System
CO997_RS14300	COG1737	Transcriptional regulator
CO997_RS14425	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CO997_RS14430	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CO997_RS14435	COG0783	Belongs to the Dps family
CO997_RS14440	COG1070	Carbohydrate kinase
CO997_RS14445	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CO997_RS14450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO997_RS14455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO997_RS14465	COG1554	hydrolase, family 65, central catalytic
CO997_RS14470	COG0673	inositol 2-dehydrogenase activity
CO997_RS14475	COG1082	Xylose isomerase domain protein TIM barrel
CO997_RS14480	COG1063	alcohol dehydrogenase
CO997_RS14485	COG0395	ABC-type sugar transport system, permease component
CO997_RS14490	COG1175	transmembrane transport
CO997_RS14495	COG1653	transport
CO997_RS14500	COG0366	Alpha amylase catalytic
CO997_RS14505	COG1609	Transcriptional regulator
CO997_RS14510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CO997_RS14515	COG0085	RNA polymerase activity
CO997_RS14530	COG4120	Belongs to the binding-protein-dependent transport system permease family
CO997_RS14555	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CO997_RS14555	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CO997_RS14570	COG0142	geranyltranstransferase activity
CO997_RS14590	COG4939	FMN-binding domain protein
CO997_RS14610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO997_RS14615	COG0826	peptidase U32
CO997_RS14620	COG0826	peptidase U32
CO997_RS14635	COG0542	response to heat
CO997_RS14640	COG4463	regulation of RNA biosynthetic process
CO997_RS14720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CO997_RS14730	COG0517	IMP dehydrogenase activity
CO997_RS14730	COG0516	GMP reductase activity
CO997_RS14750	COG0012	GTP binding
CO997_RS14755	COG4481	Protein conserved in bacteria
CO997_RS14760	COG1475	DNA binding
CO997_RS14765	COG1192	Involved in chromosome partitioning
CO997_RS14770	COG0357	Ribosomal RNA small subunit methyltransferase G
CO997_RS14775	COG0445	tRNA wobble uridine modification
CO997_RS14780	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CO997_RS14790	COG1847	R3H domain protein
CO997_RS14795	COG0706	membrane insertase activity
CO997_RS14800	COG0594	ribonuclease P activity
CO997_RS14805	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CO997_RS14860	COG0629	single-stranded DNA binding
CO997_RS14915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO997_RS14935	COG1192	Involved in chromosome partitioning
CO997_RS15165	COG0629	single-stranded DNA binding
CO997_RS15170	COG0629	single-stranded DNA binding
CO997_RS15245	COG3328	transposase activity
CO997_RS15265	COG3775	system Galactitol-specific IIC component
CO997_RS15280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CO997_RS15290	COG4372	Transposase
CO997_RS15305	COG4372	Transposase
CO997_RS15345	COG1940	carbohydrate kinase activity
CO997_RS15355	COG2190	(PTS) system
CO997_RS15355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS15355	COG1263	PTS System
CO997_RS15360	COG1621	beta-fructofuranosidase activity
CO997_RS15365	COG1609	Transcriptional regulator
CO997_RS15400	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CO997_RS15405	COG1263	PTS System
CO997_RS15405	COG2190	(PTS) system
CO997_RS15405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS15410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO997_RS15410	COG1263	PTS System
CO997_RS15410	COG2190	(PTS) system
CO997_RS15445	COG4974	Belongs to the 'phage' integrase family
CO997_RS15475	COG3328	transposase activity
CO997_RS15485	COG3684	Belongs to the aldolase LacD family
CO997_RS15490	COG2222	sugar isomerase
CO997_RS15495	COG2188	Transcriptional regulator
CO997_RS15505	COG3328	transposase activity
CO997_RS15515	COG3328	transposase activity
CO997_RS15520	COG3328	transposase activity
CO997_RS15535	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CO997_RS15540	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CO997_RS15545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CO997_RS15565	COG4372	Transposase
CO997_RS15570	COG3328	transposase activity
CO997_RS15595	COG3328	transposase activity
CO997_RS15650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CO997_RS15665	COG3409	Peptidoglycan-binding domain 1 protein
CO997_RS15750	COG3052	prosthetic group binding
CO997_RS15760	COG3493	citrate carrier protein
CO997_RS15765	COG0281	malic enzyme
CO997_RS15810	COG1940	carbohydrate kinase activity
CO997_RS15820	COG0395	ABC-type sugar transport system, permease component
CO997_RS15825	COG1175	transmembrane transport
CO997_RS15835	COG1609	Transcriptional regulator
CO997_RS15875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO997_RS15905	COG1053	succinate dehydrogenase
CO997_RS15905	COG0431	NADPH-dependent FMN reductase
CO997_RS15905	COG3976	FMN-binding domain protein
CO997_RS15985	COG0772	Belongs to the SEDS family
CO997_RS16280	COG0629	single-stranded DNA binding
CO997_RS16285	COG0629	single-stranded DNA binding
CO997_RS16360	COG3328	transposase activity
CO997_RS16420	COG4372	Transposase
CO997_RS16460	COG1940	carbohydrate kinase activity
CO997_RS16505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO997_RS16530	COG1192	Involved in chromosome partitioning