locus-tag	class	description
FHK66_RS00005	COG1302	Protein conserved in bacteria
FHK66_RS00010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FHK66_RS00015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FHK66_RS00020	COG1570	exodeoxyribonuclease VII activity
FHK66_RS00025	COG1722	exodeoxyribonuclease VII activity
FHK66_RS00035	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FHK66_RS00040	COG1438	arginine binding
FHK66_RS00045	COG0497	DNA recombination
FHK66_RS00080	COG0768	penicillin binding
FHK66_RS00115	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FHK66_RS00120	COG1799	cell septum assembly
FHK66_RS00130	COG2302	S4 RNA-binding domain
FHK66_RS00135	COG3599	regulation of cell shape
FHK66_RS00140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FHK66_RS00145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FHK66_RS00165	COG0673	inositol 2-dehydrogenase activity
FHK66_RS00170	COG0513	Belongs to the DEAD box helicase family
FHK66_RS00175	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FHK66_RS00175	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FHK66_RS00180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHK66_RS00185	COG1447	Phosphotransferase system cellobiose-specific component IIA
FHK66_RS00190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHK66_RS00240	COG1396	sequence-specific DNA binding
FHK66_RS00385	COG0740	serine-type endopeptidase activity
FHK66_RS00505	COG2309	aminopeptidase activity
FHK66_RS00515	COG0716	FMN binding
FHK66_RS00520	COG0024	Methionine aminopeptidase
FHK66_RS00525	COG1295	ribonuclease BN
FHK66_RS00530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FHK66_RS00545	COG1215	transferase activity, transferring glycosyl groups
FHK66_RS00550	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FHK66_RS00560	COG1088	dTDP-glucose 4,6-dehydratase activity
FHK66_RS00565	COG1091	dTDP-4-dehydrorhamnose reductase activity
FHK66_RS00580	COG1682	transport, permease protein
FHK66_RS00590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FHK66_RS00595	COG0438	transferase activity, transferring glycosyl groups
FHK66_RS00595	COG1216	Glycosyl transferase, family 2
FHK66_RS00605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FHK66_RS00610	COG0463	Glycosyl transferase, family 2
FHK66_RS00615	COG0438	transferase activity, transferring glycosyl groups
FHK66_RS00640	COG1086	Polysaccharide biosynthesis protein
FHK66_RS00645	COG2089	acid synthase
FHK66_RS00650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FHK66_RS00660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FHK66_RS00675	COG1083	cytidylyl-transferase
FHK66_RS00715	COG4485	Bacterial membrane protein, YfhO
FHK66_RS00730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FHK66_RS00735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FHK66_RS00745	COG4585	Histidine kinase
FHK66_RS00755	COG0569	domain protein
FHK66_RS00780	COG2246	polysaccharide biosynthetic process
FHK66_RS00785	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FHK66_RS00795	COG1316	TRANSCRIPTIONal
FHK66_RS00800	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FHK66_RS00805	COG3397	chitin binding
FHK66_RS00810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FHK66_RS00815	COG2137	regulation of response to DNA damage stimulus
FHK66_RS00820	COG1194	a g-specific adenine glycosylase
FHK66_RS00825	COG3557	Belongs to the UPF0374 family
FHK66_RS00835	COG0628	permease
FHK66_RS00840	COG1253	flavin adenine dinucleotide binding
FHK66_RS00850	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FHK66_RS00875	COG0542	response to heat
FHK66_RS00880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS00885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FHK66_RS00895	COG0438	transferase activity, transferring glycosyl groups
FHK66_RS00900	COG2084	Dehydrogenase
FHK66_RS00905	COG4703	Protein of unknown function (DUF1797)
FHK66_RS00910	COG0322	excinuclease ABC activity
FHK66_RS00930	COG1846	Transcriptional regulator
FHK66_RS00935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FHK66_RS00945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FHK66_RS00955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FHK66_RS00965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FHK66_RS00970	COG0439	Biotin carboxylase
FHK66_RS00975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FHK66_RS00980	COG0825	malonyl-CoA metabolic process
FHK66_RS00985	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FHK66_RS00990	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FHK66_RS00995	COG1534	Rna-binding protein
FHK66_RS01000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FHK66_RS01005	COG1713	HD superfamily hydrolase involved in NAD metabolism
FHK66_RS01010	COG0799	negative regulation of ribosome biogenesis
FHK66_RS01015	COG2226	methyltransferase
FHK66_RS01020	COG1323	Belongs to the UPF0348 family
FHK66_RS01025	COG0217	transcriptional regulatory protein
FHK66_RS01035	COG3973	AAA domain
FHK66_RS01040	COG2217	Heavy metal translocating P-type atpase
FHK66_RS01045	COG1942	4-Oxalocrotonate Tautomerase
FHK66_RS01055	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FHK66_RS01060	COG1737	Transcriptional regulator
FHK66_RS01065	COG0768	penicillin binding
FHK66_RS01070	COG0561	phosphatase activity
FHK66_RS01075	COG2252	PERMEase
FHK66_RS01080	COG2814	Major facilitator Superfamily
FHK66_RS01090	COG0587	DNA-directed DNA polymerase activity
FHK66_RS01095	COG0205	6-phosphofructokinase activity
FHK66_RS01105	COG0583	DNA-binding transcription factor activity
FHK66_RS01115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FHK66_RS01120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FHK66_RS01125	COG0745	RESPONSE REGULATOR receiver
FHK66_RS01130	COG5002	protein histidine kinase activity
FHK66_RS01235	COG3711	transcriptional antiterminator
FHK66_RS01245	COG1263	PTS System
FHK66_RS01245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS01245	COG2190	(PTS) system
FHK66_RS01250	COG1486	melibiose metabolic process
FHK66_RS01255	COG1263	PTS System
FHK66_RS01255	COG2190	(PTS) system
FHK66_RS01255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS01260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHK66_RS01285	COG1349	DNA-binding transcription factor activity
FHK66_RS01310	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FHK66_RS01315	COG3623	hexulose-6-phosphate isomerase
FHK66_RS01325	COG0456	acetyltransferase
FHK66_RS01355	COG3711	transcriptional antiterminator
FHK66_RS01390	COG3964	amidohydrolase
FHK66_RS01405	COG3328	transposase activity
FHK66_RS01410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS01410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FHK66_RS01410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FHK66_RS01415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS01415	COG3711	transcriptional antiterminator
FHK66_RS01420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FHK66_RS01425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FHK66_RS01430	COG0789	Transcriptional regulator
FHK66_RS01445	COG1105	Belongs to the carbohydrate kinase PfkB family
FHK66_RS01450	COG1349	DNA-binding transcription factor activity
FHK66_RS01455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS01470	COG3775	system Galactitol-specific IIC component
FHK66_RS01485	COG0400	carboxylic ester hydrolase activity
FHK66_RS01490	COG0346	lactoylglutathione lyase activity
FHK66_RS01500	COG2188	Transcriptional regulator
FHK66_RS01505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHK66_RS01510	COG2723	6-phospho-beta-galactosidase activity
FHK66_RS01515	COG0589	response to stress
FHK66_RS01530	COG1393	Belongs to the ArsC family
FHK66_RS01550	COG0351	phosphomethylpyrimidine kinase
FHK66_RS01555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FHK66_RS01560	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FHK66_RS01570	COG3425	synthase
FHK66_RS01575	COG0183	Belongs to the thiolase family
FHK66_RS01590	COG0656	L-ascorbic acid biosynthetic process
FHK66_RS01610	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FHK66_RS01610	COG0392	lysyltransferase activity
FHK66_RS01615	COG0596	Alpha beta hydrolase
FHK66_RS01620	COG0741	lytic transglycosylase activity
FHK66_RS01630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FHK66_RS01635	COG0358	DNA primase activity
FHK66_RS01640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FHK66_RS01650	COG2996	Protein conserved in bacteria
FHK66_RS01655	COG0735	belongs to the Fur family
FHK66_RS01660	COG4974	Belongs to the 'phage' integrase family
FHK66_RS01670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FHK66_RS01675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FHK66_RS01680	COG1187	pseudouridine synthase activity
FHK66_RS01685	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FHK66_RS01690	COG1288	antiporter activity
FHK66_RS01695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FHK66_RS01715	COG0514	ATP-dependent DNA helicase (RecQ)
FHK66_RS01720	COG3942	CHAP domain
FHK66_RS01720	COG1388	LysM domain
FHK66_RS01725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FHK66_RS01730	COG0539	negative regulation of cytoplasmic translation
FHK66_RS01735	COG1160	GTP binding
FHK66_RS01740	COG0776	regulation of translation
FHK66_RS01755	COG0457	Tetratricopeptide repeat
FHK66_RS01760	COG5582	Belongs to the UPF0302 family
FHK66_RS01765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHK66_RS01770	COG1694	Mazg nucleotide pyrophosphohydrolase
FHK66_RS01775	COG0617	tRNA 3'-terminal CCA addition
FHK66_RS01790	COG0025	NhaP-type Na H and K H
FHK66_RS01795	COG0488	(ABC) transporter
FHK66_RS01800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FHK66_RS01810	COG1272	protein, Hemolysin III
FHK66_RS01815	COG1307	EDD domain protein, DegV family
FHK66_RS01820	COG2755	lipolytic protein G-D-S-L family
FHK66_RS01825	COG4698	Protein conserved in bacteria
FHK66_RS01835	COG4479	Belongs to the UPF0346 family
FHK66_RS01840	COG0681	Belongs to the peptidase S26 family
FHK66_RS01855	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FHK66_RS01860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FHK66_RS01865	COG0758	DNA mediated transformation
FHK66_RS01870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FHK66_RS01875	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FHK66_RS01880	COG4974	Belongs to the 'phage' integrase family
FHK66_RS01885	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FHK66_RS01890	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FHK66_RS01905	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FHK66_RS01910	COG1832	CoA-binding protein
FHK66_RS01915	COG0187	DNA topoisomerase II activity
FHK66_RS01925	COG1882	Formate acetyltransferase
FHK66_RS01930	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FHK66_RS01935	COG1227	inorganic diphosphatase activity
FHK66_RS01955	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FHK66_RS01965	COG1073	alpha beta
FHK66_RS01970	COG1609	Transcriptional regulator
FHK66_RS01980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHK66_RS02000	COG1732	Glycine betaine
FHK66_RS02015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FHK66_RS02030	COG0084	hydrolase, TatD family'
FHK66_RS02035	COG1388	LysM domain
FHK66_RS02035	COG3942	CHAP domain
FHK66_RS02050	COG0346	lactoylglutathione lyase activity
FHK66_RS02070	COG0436	Aminotransferase
FHK66_RS02090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FHK66_RS02095	COG4565	transcriptional regulatory protein
FHK66_RS02100	COG3290	protein histidine kinase activity
FHK66_RS02110	COG2268	Band 7 protein
FHK66_RS02130	COG0673	inositol 2-dehydrogenase activity
FHK66_RS02140	COG1876	peptidase activity
FHK66_RS02155	COG1653	transport
FHK66_RS02160	COG1175	transmembrane transport
FHK66_RS02165	COG0395	ABC-type sugar transport system, permease component
FHK66_RS02180	COG0673	inositol 2-dehydrogenase activity
FHK66_RS02185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FHK66_RS02190	COG2233	PERMEase
FHK66_RS02200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FHK66_RS02205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FHK66_RS02210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FHK66_RS02220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FHK66_RS02225	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FHK66_RS02230	COG0047	phosphoribosylformylglycinamidine synthase activity
FHK66_RS02235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FHK66_RS02245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FHK66_RS02250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FHK66_RS02255	COG0138	bifunctional purine biosynthesis protein purh
FHK66_RS02260	COG0151	Belongs to the GarS family
FHK66_RS02265	COG4989	oxidoreductase activity
FHK66_RS02280	COG2972	Histidine kinase
FHK66_RS02285	COG1879	ABC-type sugar transport system periplasmic component
FHK66_RS02290	COG4213	ABC transporter substrate-binding protein
FHK66_RS02300	COG4214	carbohydrate transport
FHK66_RS02305	COG0516	GMP reductase activity
FHK66_RS02315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FHK66_RS02330	COG0022	dehydrogenase e1 component
FHK66_RS02345	COG4476	Belongs to the UPF0223 family
FHK66_RS02350	COG0483	inositol monophosphate 1-phosphatase activity
FHK66_RS02355	COG1217	gtp-binding protein TYPA
FHK66_RS02360	COG0514	ATP-dependent DNA helicase (RecQ)
FHK66_RS02365	COG4838	Belongs to the UPF0358 family
FHK66_RS02370	COG0772	Belongs to the SEDS family
FHK66_RS02375	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FHK66_RS02390	COG4471	UPF0298 protein
FHK66_RS02395	COG0742	ribosomal rna small subunit methyltransferase
FHK66_RS02400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FHK66_RS02405	COG3480	Lon protease (S16) C-terminal proteolytic domain
FHK66_RS02410	COG1596	polysaccharide export
FHK66_RS02410	COG1555	photosystem II stabilization
FHK66_RS02425	COG2131	deaminase
FHK66_RS02435	COG1466	dna polymerase III delta subunit
FHK66_RS02445	COG0268	Binds directly to 16S ribosomal RNA
FHK66_RS02455	COG2707	UPF0756 membrane protein
FHK66_RS02460	COG2217	Heavy metal translocating P-type atpase
FHK66_RS02465	COG1968	undecaprenyl-diphosphatase activity
FHK66_RS02485	COG1666	GTP binding
FHK66_RS02490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHK66_RS02495	COG2151	metal-sulfur cluster biosynthetic enzyme
FHK66_RS02510	COG1388	LysM domain
FHK66_RS02510	COG3942	CHAP domain
FHK66_RS02575	COG4990	cell redox homeostasis
FHK66_RS02605	COG3104	oligopeptide transport
FHK66_RS02610	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FHK66_RS02615	COG1074	ATP-dependent DNA helicase activity
FHK66_RS02620	COG1733	regulation of RNA biosynthetic process
FHK66_RS02625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FHK66_RS02630	COG0072	phenylalanine-tRNA ligase activity
FHK66_RS02630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FHK66_RS02640	COG1126	abc transporter atp-binding protein
FHK66_RS02645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FHK66_RS02650	COG0765	amino acid transport
FHK66_RS02655	COG0765	amino acid transport
FHK66_RS02660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FHK66_RS02665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FHK66_RS02675	COG0517	IMP dehydrogenase activity
FHK66_RS02680	COG0668	transmembrane transport
FHK66_RS02685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FHK66_RS02690	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FHK66_RS02695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FHK66_RS02720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FHK66_RS02730	COG1234	tRNA 3'-trailer cleavage
FHK66_RS02735	COG0300	oxidoreductase activity
FHK66_RS02740	COG5416	Lipopolysaccharide assembly protein A domain
FHK66_RS02745	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FHK66_RS02745	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FHK66_RS02750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FHK66_RS02760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FHK66_RS02775	COG1705	Flagellar rod assembly protein muramidase FlgJ
FHK66_RS02775	COG1388	LysM domain
FHK66_RS02780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FHK66_RS02785	COG0735	belongs to the Fur family
FHK66_RS02790	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHK66_RS02800	COG1846	Transcriptional regulator
FHK66_RS02810	COG3935	DnaD domain protein
FHK66_RS02815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FHK66_RS02830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FHK66_RS02835	COG3331	DNA recombination
FHK66_RS02840	COG4474	Belongs to the UPF0398 family
FHK66_RS02845	COG3599	regulation of cell shape
FHK66_RS02855	COG0116	Belongs to the methyltransferase superfamily
FHK66_RS02860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FHK66_RS02865	COG1418	mRNA catabolic process
FHK66_RS02885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FHK66_RS02890	COG0531	amino acid
FHK66_RS02905	COG0513	Belongs to the DEAD box helicase family
FHK66_RS02910	COG2153	protein acetylation
FHK66_RS02920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FHK66_RS02925	COG4684	Psort location CytoplasmicMembrane, score
FHK66_RS02940	COG0328	RNA-DNA hybrid ribonuclease activity
FHK66_RS02950	COG1278	Cold shock
FHK66_RS02955	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FHK66_RS02970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FHK66_RS02975	COG0564	pseudouridine synthase activity
FHK66_RS02985	COG2233	PERMEase
FHK66_RS02990	COG0540	Belongs to the ATCase OTCase family
FHK66_RS02995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FHK66_RS03000	COG0505	Belongs to the CarA family
FHK66_RS03005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FHK66_RS03010	COG0543	2 iron, 2 sulfur cluster binding
FHK66_RS03020	COG0284	orotidine-5'-phosphate decarboxylase activity
FHK66_RS03050	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FHK66_RS03070	COG4120	Belongs to the binding-protein-dependent transport system permease family
FHK66_RS03080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FHK66_RS03115	COG0039	L-malate dehydrogenase activity
FHK66_RS03135	COG3037	sugar-specific permease SgaT UlaA
FHK66_RS03145	COG3711	transcriptional antiterminator
FHK66_RS03155	COG0673	inositol 2-dehydrogenase activity
FHK66_RS03195	COG0745	RESPONSE REGULATOR receiver
FHK66_RS03200	COG5002	protein histidine kinase activity
FHK66_RS03210	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
FHK66_RS03225	COG0351	phosphomethylpyrimidine kinase
FHK66_RS03235	COG4475	Protein of unknown function (DUF436)
FHK66_RS03240	COG0366	Alpha amylase catalytic
FHK66_RS03255	COG1307	EDD domain protein, DegV family
FHK66_RS03260	COG2244	polysaccharide biosynthetic process
FHK66_RS03315	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FHK66_RS03320	COG0194	GDP metabolic process
FHK66_RS03340	COG0765	amino acid transport
FHK66_RS03345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FHK66_RS03355	COG0167	dihydroorotate dehydrogenase activity
FHK66_RS03380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FHK66_RS03390	COG3833	ABC-type maltose transport systems, permease component
FHK66_RS03395	COG1175	transmembrane transport
FHK66_RS03400	COG2182	Extracellular solute-binding protein
FHK66_RS03405	COG0366	Alpha amylase catalytic
FHK66_RS03415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHK66_RS03425	COG1764	response to oxidative stress
FHK66_RS03430	COG1846	Transcriptional regulator
FHK66_RS03435	COG0628	permease
FHK66_RS03455	COG1312	Catalyzes the dehydration of D-mannonate
FHK66_RS03470	COG0450	alkyl hydroperoxide reductase
FHK66_RS03495	COG0768	penicillin binding
FHK66_RS03500	COG3328	transposase activity
FHK66_RS03510	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHK66_RS03540	COG0534	Mate efflux family protein
FHK66_RS03550	COG0504	CTP synthase activity
FHK66_RS03570	COG3328	transposase activity
FHK66_RS03580	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FHK66_RS03595	COG3328	transposase activity
FHK66_RS03610	COG0531	amino acid
FHK66_RS03615	COG0004	ammonium transporteR
FHK66_RS03630	COG2261	transglycosylase associated protein
FHK66_RS03650	COG3328	transposase activity
FHK66_RS03665	COG3655	Transcriptional regulator
FHK66_RS03680	COG2261	transglycosylase associated protein
FHK66_RS03700	COG1028	Short-chain dehydrogenase reductase Sdr
FHK66_RS03715	COG1442	glycosyl transferase family 8
FHK66_RS03720	COG1442	glycosyl transferase family 8
FHK66_RS03725	COG0561	phosphatase activity
FHK66_RS03755	COG3732	PTS system glucitol sorbitol-specific
FHK66_RS03760	COG3730	PTS system glucitol sorbitol-specific
FHK66_RS03835	COG0640	Transcriptional regulator
FHK66_RS03840	COG1278	Cold shock
FHK66_RS03860	COG0481	GTPase activity
FHK66_RS03880	COG0542	response to heat
FHK66_RS03915	COG1597	lipid kinase activity
FHK66_RS03920	COG2195	Cleaves the N-terminal amino acid of tripeptides
FHK66_RS03925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FHK66_RS03930	COG2384	SAM-dependent methyltransferase
FHK66_RS03940	COG1484	DNA-dependent DNA replication
FHK66_RS03950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FHK66_RS03965	COG0237	dephospho-CoA kinase activity
FHK66_RS03970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FHK66_RS03975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FHK66_RS03975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FHK66_RS03990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FHK66_RS03995	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FHK66_RS04000	COG3091	SprT-like family
FHK66_RS04005	COG2183	response to ionizing radiation
FHK66_RS04015	COG1054	Belongs to the UPF0176 family
FHK66_RS04035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHK66_RS04040	COG0588	phosphoglycerate mutase activity
FHK66_RS04095	COG2972	Histidine kinase
FHK66_RS04100	COG0077	Prephenate dehydratase
FHK66_RS04105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FHK66_RS04110	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FHK66_RS04115	COG0287	Prephenate dehydrogenase
FHK66_RS04120	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FHK66_RS04130	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FHK66_RS04140	COG3250	beta-galactosidase activity
FHK66_RS04155	COG1609	Transcriptional regulator
FHK66_RS04175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FHK66_RS04180	COG1597	lipid kinase activity
FHK66_RS04185	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FHK66_RS04190	COG0154	amidase activity
FHK66_RS04195	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FHK66_RS04200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FHK66_RS04205	COG0210	DNA helicase
FHK66_RS04215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FHK66_RS04215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS04215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FHK66_RS04220	COG1105	Belongs to the carbohydrate kinase PfkB family
FHK66_RS04225	COG1349	DNA-binding transcription factor activity
FHK66_RS04240	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FHK66_RS04245	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FHK66_RS04250	COG0544	peptidyl-prolyl cis-trans isomerase activity
FHK66_RS04260	COG1714	RDD family
FHK66_RS04275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FHK66_RS04280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FHK66_RS04320	COG1481	regulation of sporulation
FHK66_RS04325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FHK66_RS04330	COG1660	Displays ATPase and GTPase activities
FHK66_RS04345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FHK66_RS04350	COG0556	nucleotide-excision repair
FHK66_RS04355	COG0765	amino acid transport
FHK66_RS04360	COG1126	abc transporter atp-binding protein
FHK66_RS04370	COG0484	heat shock protein binding
FHK66_RS04375	COG0443	Heat shock 70 kDa protein
FHK66_RS04380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FHK66_RS04385	COG1420	regulation of RNA biosynthetic process
FHK66_RS04390	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FHK66_RS04420	COG0693	protein deglycase activity
FHK66_RS04430	COG1619	proteins homologs of microcin C7 resistance protein MccF
FHK66_RS04440	COG5646	InterPro IPR014922
FHK66_RS04450	COG4975	Glucose uptake
FHK66_RS04460	COG0196	riboflavin kinase activity
FHK66_RS04465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FHK66_RS04470	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FHK66_RS04475	COG1175	transmembrane transport
FHK66_RS04480	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FHK66_RS04495	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FHK66_RS04500	COG0195	Participates in both transcription termination and antitermination
FHK66_RS04505	COG0779	Required for maturation of 30S ribosomal subunits
FHK66_RS04510	COG2176	DNA-directed DNA polymerase activity
FHK66_RS04515	COG0442	prolyl-tRNA aminoacylation
FHK66_RS04520	COG0750	zinc metalloprotease
FHK66_RS04525	COG4589	Belongs to the CDS family
FHK66_RS04530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FHK66_RS04540	COG0233	cytoplasmic translational termination
FHK66_RS04545	COG0528	UMP kinase activity
FHK66_RS04550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FHK66_RS04555	COG0052	Belongs to the universal ribosomal protein uS2 family
FHK66_RS04560	COG1438	arginine binding
FHK66_RS04570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHK66_RS04580	COG0018	arginyl-trna synthetase
FHK66_RS04595	COG2235	arginine
FHK66_RS04600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FHK66_RS04605	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FHK66_RS04610	COG0456	acetyltransferase
FHK66_RS04620	COG1214	PFAM Peptidase M22, glycoprotease
FHK66_RS04625	COG1609	Transcriptional regulator
FHK66_RS04630	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
FHK66_RS04635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FHK66_RS04650	COG3189	MarR family transcriptional regulator
FHK66_RS04655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FHK66_RS04660	COG1940	carbohydrate kinase activity
FHK66_RS04675	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FHK66_RS04680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FHK66_RS04685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FHK66_RS04690	COG1120	ATPase activity
FHK66_RS04705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FHK66_RS04710	COG4876	unkown
FHK66_RS04715	COG0367	asparagine synthase
FHK66_RS04720	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FHK66_RS05010	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FHK66_RS05035	COG1309	transcriptional regulator
FHK66_RS05055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FHK66_RS05065	COG0584	glycerophosphoryl diester phosphodiesterase
FHK66_RS05090	COG0166	Belongs to the GPI family
FHK66_RS05095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FHK66_RS05100	COG2081	HI0933 family
FHK66_RS05105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FHK66_RS05110	COG0710	3-dehydroquinate dehydratase activity
FHK66_RS05115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FHK66_RS05120	COG1368	sulfuric ester hydrolase activity
FHK66_RS05140	COG3850	Histidine kinase
FHK66_RS05140	COG5002	protein histidine kinase activity
FHK66_RS05145	COG0745	RESPONSE REGULATOR receiver
FHK66_RS05190	COG0584	glycerophosphoryl diester phosphodiesterase
FHK66_RS05225	COG1956	GAF domain-containing protein
FHK66_RS05230	COG3527	Alpha-acetolactate decarboxylase
FHK66_RS05235	COG0028	Belongs to the TPP enzyme family
FHK66_RS05245	COG0395	ABC-type sugar transport system, permease component
FHK66_RS05250	COG1175	transmembrane transport
FHK66_RS05285	COG4974	Belongs to the 'phage' integrase family
FHK66_RS05330	COG1131	(ABC) transporter
FHK66_RS05375	COG0791	NLP P60 protein
FHK66_RS05375	COG0741	lytic transglycosylase activity
FHK66_RS05425	COG2946	Replication initiation factor
FHK66_RS05435	COG1674	ftsk spoiiie
FHK66_RS05465	COG0335	large ribosomal subunit rRNA binding
FHK66_RS05470	COG0336	Belongs to the RNA methyltransferase TrmD family
FHK66_RS05475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FHK66_RS05485	COG1837	Belongs to the UPF0109 family
FHK66_RS05490	COG0228	four-way junction DNA binding
FHK66_RS05495	COG0431	NADPH-dependent FMN reductase
FHK66_RS05500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FHK66_RS05505	COG0519	Catalyzes the synthesis of GMP from XMP
FHK66_RS05510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FHK66_RS05515	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FHK66_RS05525	COG0745	RESPONSE REGULATOR receiver
FHK66_RS05530	COG5002	protein histidine kinase activity
FHK66_RS05535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FHK66_RS05540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FHK66_RS05565	COG0714	Associated with various cellular activities
FHK66_RS05575	COG1305	Transglutaminase-like
FHK66_RS05580	COG2217	Heavy metal translocating P-type atpase
FHK66_RS05585	COG2217	Heavy metal translocating P-type atpase
FHK66_RS05590	COG2608	mercury ion transmembrane transporter activity
FHK66_RS05595	COG3682	Transcriptional regulator
FHK66_RS05605	COG0531	amino acid
FHK66_RS05610	COG2217	Heavy metal translocating P-type atpase
FHK66_RS05640	COG0017	Asparaginyl-tRNA synthetase
FHK66_RS05645	COG0436	Aminotransferase
FHK66_RS05655	COG1199	ATP-dependent helicase activity
FHK66_RS05655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FHK66_RS05660	COG1278	Cold shock
FHK66_RS05675	COG1686	Belongs to the peptidase S11 family
FHK66_RS05685	COG0038	chloride channel
FHK66_RS05700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FHK66_RS05705	COG1254	Belongs to the acylphosphatase family
FHK66_RS05720	COG0706	membrane insertase activity
FHK66_RS05730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FHK66_RS05730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS05730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS05740	COG1105	Belongs to the carbohydrate kinase PfkB family
FHK66_RS05750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FHK66_RS05760	COG2244	polysaccharide biosynthetic process
FHK66_RS05765	COG1215	transferase activity, transferring glycosyl groups
FHK66_RS05775	COG0438	transferase activity, transferring glycosyl groups
FHK66_RS05795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FHK66_RS05800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FHK66_RS05810	COG4464	protein tyrosine phosphatase activity
FHK66_RS05815	COG0489	protein tyrosine kinase activity
FHK66_RS05820	COG3944	biosynthesis protein
FHK66_RS05825	COG1316	TRANSCRIPTIONal
FHK66_RS05840	COG0751	glycine-tRNA ligase activity
FHK66_RS05845	COG0752	glycyl-tRNA synthetase alpha subunit
FHK66_RS05850	COG1381	Involved in DNA repair and RecF pathway recombination
FHK66_RS05855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FHK66_RS05860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FHK66_RS05865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FHK66_RS05875	COG1702	phosphate starvation-inducible protein PhoH
FHK66_RS05880	COG1114	Component of the transport system for branched-chain amino acids
FHK66_RS05885	COG1610	YqeY-like protein
FHK66_RS05890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FHK66_RS05895	COG0735	belongs to the Fur family
FHK66_RS05900	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FHK66_RS05905	COG0640	Transcriptional regulator
FHK66_RS05910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FHK66_RS05915	COG0492	ferredoxin-NADP+ reductase activity
FHK66_RS05920	COG2723	6-phospho-beta-galactosidase activity
FHK66_RS05925	COG1486	melibiose metabolic process
FHK66_RS05935	COG1737	Transcriptional regulator
FHK66_RS05960	COG3711	transcriptional antiterminator
FHK66_RS05970	COG1132	(ABC) transporter
FHK66_RS05975	COG1132	(ABC) transporter
FHK66_RS05980	COG3763	UPF0154 protein
FHK66_RS05985	COG1914	H( )-stimulated, divalent metal cation uptake system
FHK66_RS06000	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FHK66_RS06010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FHK66_RS06010	COG4499	WXG100 protein secretion system (Wss), protein YukC
FHK66_RS06015	COG1609	Transcriptional regulator
FHK66_RS06025	COG4980	gas vesicle protein
FHK66_RS06035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FHK66_RS06040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FHK66_RS06045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FHK66_RS06050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FHK66_RS06055	COG1950	PFAM Membrane protein of
FHK66_RS06080	COG0704	Plays a role in the regulation of phosphate uptake
FHK66_RS06085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FHK66_RS06090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FHK66_RS06095	COG0581	inorganic phosphate transmembrane transporter activity
FHK66_RS06100	COG0573	inorganic phosphate transmembrane transporter activity
FHK66_RS06105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FHK66_RS06110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FHK66_RS06115	COG2177	Part of the ABC transporter FtsEX involved in
FHK66_RS06120	COG2884	Cell division ATP-binding protein ftsE
FHK66_RS06130	COG0653	protein targeting
FHK66_RS06145	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FHK66_RS06150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHK66_RS06160	COG1739	Uncharacterized protein family UPF0029
FHK66_RS06165	COG2188	Transcriptional regulator
FHK66_RS06185	COG1940	carbohydrate kinase activity
FHK66_RS06205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FHK66_RS06215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FHK66_RS06220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FHK66_RS06225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FHK66_RS06230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FHK66_RS06235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FHK66_RS06240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FHK66_RS06245	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FHK66_RS06250	COG0356	it plays a direct role in the translocation of protons across the membrane
FHK66_RS06255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FHK66_RS06260	COG0557	exoribonuclease II activity
FHK66_RS06270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FHK66_RS06275	COG2388	GCN5-related N-acetyl-transferase
FHK66_RS06305	COG0149	triose-phosphate isomerase activity
FHK66_RS06310	COG0126	phosphoglycerate kinase activity
FHK66_RS06320	COG2390	Transcriptional regulator
FHK66_RS06325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FHK66_RS06345	COG1595	DNA-templated transcription, initiation
FHK66_RS06365	COG0095	Lipoate-protein ligase
FHK66_RS06370	COG1078	dGTPase activity
FHK66_RS06375	COG0561	phosphatase activity
FHK66_RS06380	COG0494	nUDIX hydrolase
FHK66_RS06385	COG0346	lactoylglutathione lyase activity
FHK66_RS06395	COG2423	ornithine cyclodeaminase activity
FHK66_RS06400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FHK66_RS06405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FHK66_RS06410	COG1394	ATPase activity, coupled to movement of substances
FHK66_RS06415	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
FHK66_RS06420	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
FHK66_RS06425	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
FHK66_RS06430	COG1527	subunit (C
FHK66_RS06435	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
FHK66_RS06440	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FHK66_RS06445	COG1269	ATP hydrolysis coupled proton transport
FHK66_RS06455	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FHK66_RS06460	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FHK66_RS06470	COG4152	abc transporter atp-binding protein
FHK66_RS06475	COG0322	excinuclease ABC activity
FHK66_RS06480	COG3118	belongs to the thioredoxin family
FHK66_RS06485	COG1193	negative regulation of DNA recombination
FHK66_RS06500	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FHK66_RS06515	COG1136	(ABC) transporter
FHK66_RS06525	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHK66_RS06560	COG1304	FMN binding
FHK66_RS06570	COG0281	malic enzyme
FHK66_RS06655	COG4974	Belongs to the 'phage' integrase family
FHK66_RS06660	COG3906	Belongs to the UPF0473 family
FHK66_RS06665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FHK66_RS06670	COG4472	Bacterial protein of unknown function (DUF965)
FHK66_RS06700	COG3689	TIGRFAM TIGR03943 family protein
FHK66_RS06705	COG0701	Predicted permease
FHK66_RS06715	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FHK66_RS06720	COG0488	(ABC) transporter
FHK66_RS06730	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHK66_RS06740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FHK66_RS06755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FHK66_RS06760	COG1177	transmembrane transport
FHK66_RS06765	COG1176	ABC-type spermidine putrescine transport system, permease component I
FHK66_RS06770	COG3842	ATPase activity
FHK66_RS06780	COG0604	alcohol dehydrogenase
FHK66_RS06785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FHK66_RS06790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FHK66_RS06795	COG4684	Psort location CytoplasmicMembrane, score
FHK66_RS06800	COG0702	epimerase
FHK66_RS06805	COG0604	alcohol dehydrogenase
FHK66_RS06805	COG1028	Short-chain dehydrogenase reductase Sdr
FHK66_RS06805	COG3321	synthase
FHK66_RS06810	COG1053	succinate dehydrogenase
FHK66_RS06845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FHK66_RS06855	COG0708	Exodeoxyribonuclease III
FHK66_RS06875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FHK66_RS06880	COG0802	atpase or kinase
FHK66_RS06885	COG0280	phosphate acetyltransferase
FHK66_RS06890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FHK66_RS06895	COG0561	phosphatase activity
FHK66_RS06935	COG0346	lactoylglutathione lyase activity
FHK66_RS06950	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FHK66_RS06970	COG1131	(ABC) transporter
FHK66_RS06975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FHK66_RS06995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS06995	COG1263	PTS System
FHK66_RS07000	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FHK66_RS07015	COG0488	(ABC) transporter
FHK66_RS07020	COG1929	Belongs to the glycerate kinase type-1 family
FHK66_RS07025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FHK66_RS07035	COG1113	amino acid transport
FHK66_RS07055	COG1757	Na H antiporter
FHK66_RS07065	COG1464	Belongs to the NlpA lipoprotein family
FHK66_RS07070	COG2011	ABC-type metal ion transport system permease component
FHK66_RS07075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FHK66_RS07085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHK66_RS07090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FHK66_RS07095	COG0105	UTP biosynthetic process
FHK66_RS07105	COG1368	sulfuric ester hydrolase activity
FHK66_RS07125	COG2723	6-phospho-beta-galactosidase activity
FHK66_RS07145	COG1428	Deoxynucleoside kinase
FHK66_RS07155	COG1611	Belongs to the LOG family
FHK66_RS07180	COG2188	Transcriptional regulator
FHK66_RS07185	COG2723	6-phospho-beta-galactosidase activity
FHK66_RS07190	COG1263	PTS System
FHK66_RS07190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS07190	COG2190	(PTS) system
FHK66_RS07200	COG3711	transcriptional antiterminator
FHK66_RS07205	COG3764	Sortase (surface protein transpeptidase)
FHK66_RS07270	COG1597	lipid kinase activity
FHK66_RS07295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FHK66_RS07300	COG0577	efflux transmembrane transporter activity
FHK66_RS07300	COG1136	(ABC) transporter
FHK66_RS07365	COG1674	ftsk spoiiie
FHK66_RS07370	COG2946	Replication initiation factor
FHK66_RS07405	COG0433	COG0433 Predicted ATPase
FHK66_RS07415	COG0791	NLP P60 protein
FHK66_RS07415	COG0741	lytic transglycosylase activity
FHK66_RS07420	COG2217	Heavy metal translocating P-type atpase
FHK66_RS07425	COG0640	Transcriptional regulator
FHK66_RS07430	COG0842	Transport permease protein
FHK66_RS07435	COG1131	(ABC) transporter
FHK66_RS07495	COG0719	Fe-S assembly protein
FHK66_RS07505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FHK66_RS07510	COG0719	Fe-S assembly protein
FHK66_RS07520	COG1464	Belongs to the NlpA lipoprotein family
FHK66_RS07525	COG2011	ABC-type metal ion transport system permease component
FHK66_RS07530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FHK66_RS07535	COG0509	glycine decarboxylation via glycine cleavage system
FHK66_RS07540	COG1393	Belongs to the ArsC family
FHK66_RS07545	COG0772	Belongs to the SEDS family
FHK66_RS07555	COG0583	DNA-binding transcription factor activity
FHK66_RS07575	COG2855	membrane
FHK66_RS07580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FHK66_RS07585	COG0463	Glycosyl transferase, family 2
FHK66_RS07605	COG2814	Major facilitator Superfamily
FHK66_RS07610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FHK66_RS07620	COG0482	sulfurtransferase activity
FHK66_RS07640	COG1104	cysteine desulfurase activity
FHK66_RS07645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FHK66_RS07655	COG3590	peptidase
FHK66_RS07675	COG1335	isochorismatase
FHK66_RS07680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FHK66_RS07700	COG3853	Toxic anion resistance protein (TelA)
FHK66_RS07705	COG0531	amino acid
FHK66_RS07710	COG4975	Glucose uptake
FHK66_RS07715	COG2205	protein histidine kinase activity
FHK66_RS07720	COG0745	RESPONSE REGULATOR receiver
FHK66_RS07755	COG3328	transposase activity
FHK66_RS07785	COG2135	peptidase activity
FHK66_RS07805	COG1335	isochorismatase
FHK66_RS07810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FHK66_RS07815	COG1764	response to oxidative stress
FHK66_RS07830	COG1438	arginine binding
FHK66_RS07840	COG0477	Major facilitator Superfamily
FHK66_RS07845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FHK66_RS07855	COG2823	Periplasmic or secreted lipoprotein
FHK66_RS07855	COG1652	LysM domain
FHK66_RS07860	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FHK66_RS07875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FHK66_RS07880	COG1121	(ABC) transporter
FHK66_RS07885	COG1113	amino acid transport
FHK66_RS07895	COG2249	NAD(P)H dehydrogenase (quinone) activity
FHK66_RS07900	COG2207	Transcriptional regulator
FHK66_RS07915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FHK66_RS07920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FHK66_RS07930	COG2323	membrane
FHK66_RS07940	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHK66_RS07945	COG0436	Aminotransferase
FHK66_RS07950	COG1473	amidohydrolase
FHK66_RS07955	COG0527	aspartate kinase activity
FHK66_RS07960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FHK66_RS07965	COG2171	N-acyltransferase activity
FHK66_RS07970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FHK66_RS07980	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FHK66_RS07985	COG0019	diaminopimelate decarboxylase activity
FHK66_RS07990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FHK66_RS08005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FHK66_RS08010	COG0626	cystathionine gamma-synthase activity
FHK66_RS08015	COG1854	S-ribosylhomocysteine lyase activity
FHK66_RS08025	COG0386	Belongs to the glutathione peroxidase family
FHK66_RS08050	COG1393	Belongs to the ArsC family
FHK66_RS08055	COG1393	Belongs to the ArsC family
FHK66_RS08060	COG0210	DNA helicase
FHK66_RS08075	COG1428	Deoxynucleoside kinase
FHK66_RS08095	COG3328	transposase activity
FHK66_RS08110	COG0803	Belongs to the bacterial solute-binding protein 9 family
FHK66_RS08110	COG3443	Belongs to the bacterial solute-binding protein 9 family
FHK66_RS08115	COG0628	permease
FHK66_RS08125	COG0366	Alpha amylase catalytic
FHK66_RS08145	COG1609	Transcriptional regulator
FHK66_RS08155	COG1869	D-ribose catabolic process
FHK66_RS08160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS08160	COG2190	(PTS) system
FHK66_RS08160	COG1263	PTS System
FHK66_RS08165	COG3942	CHAP domain
FHK66_RS08165	COG1705	Flagellar rod assembly protein muramidase FlgJ
FHK66_RS08180	COG1136	(ABC) transporter
FHK66_RS08215	COG1811	Na channel or pump
FHK66_RS08235	COG1136	(ABC) transporter
FHK66_RS08235	COG0577	efflux transmembrane transporter activity
FHK66_RS08235	COG1136	(ABC) transporter
FHK66_RS08235	COG0577	efflux transmembrane transporter activity
FHK66_RS08245	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FHK66_RS08250	COG0163	prenyltransferase activity
FHK66_RS08280	COG2814	Major facilitator Superfamily
FHK66_RS08290	COG1695	Transcriptional regulator
FHK66_RS08295	COG3479	Phenolic acid decarboxylase
FHK66_RS08345	COG1263	PTS System
FHK66_RS08345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS08345	COG2190	(PTS) system
FHK66_RS08355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHK66_RS08365	COG1609	Transcriptional regulator
FHK66_RS08370	COG1757	Na H antiporter
FHK66_RS08375	COG0531	amino acid
FHK66_RS08395	COG1309	transcriptional regulator
FHK66_RS08400	COG1131	(ABC) transporter
FHK66_RS08410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FHK66_RS08425	COG1461	Dihydroxyacetone kinase
FHK66_RS08430	COG2376	Dihydroxyacetone kinase
FHK66_RS08435	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FHK66_RS08455	COG3973	AAA domain
FHK66_RS08460	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHK66_RS08465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FHK66_RS08470	COG1937	Protein conserved in bacteria
FHK66_RS08490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FHK66_RS08495	COG1193	negative regulation of DNA recombination
FHK66_RS08500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FHK66_RS08505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FHK66_RS08510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FHK66_RS08525	COG0446	pyridine nucleotide-disulphide oxidoreductase
FHK66_RS08535	COG1902	pentaerythritol trinitrate reductase activity
FHK66_RS08545	COG0366	Alpha amylase catalytic
FHK66_RS08555	COG2252	PERMEase
FHK66_RS08580	COG1846	Transcriptional regulator
FHK66_RS08670	COG3052	prosthetic group binding
FHK66_RS08680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FHK66_RS08710	COG1113	amino acid transport
FHK66_RS08750	COG4716	Myosin-crossreactive antigen
FHK66_RS08760	COG1063	alcohol dehydrogenase
FHK66_RS08775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHK66_RS08780	COG1447	Phosphotransferase system cellobiose-specific component IIA
FHK66_RS08790	COG2723	6-phospho-beta-galactosidase activity
FHK66_RS08800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHK66_RS08805	COG2186	Transcriptional regulator
FHK66_RS08820	COG0101	tRNA pseudouridine synthase activity
FHK66_RS08830	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FHK66_RS08860	COG0366	Alpha amylase catalytic
FHK66_RS08910	COG2188	Transcriptional regulator
FHK66_RS08915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHK66_RS08920	COG3716	PTS system mannose fructose sorbose family IID component
FHK66_RS08925	COG3715	PTS system
FHK66_RS08935	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS08940	COG2222	sugar isomerase
FHK66_RS08955	COG2814	Major facilitator Superfamily
FHK66_RS08965	COG2207	Transcriptional regulator
FHK66_RS08985	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FHK66_RS08990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FHK66_RS08995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FHK66_RS09000	COG0589	response to stress
FHK66_RS09005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FHK66_RS09010	COG1363	Peptidase, m42
FHK66_RS09030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FHK66_RS09035	COG0824	Thioesterase
FHK66_RS09080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FHK66_RS09085	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FHK66_RS09090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FHK66_RS09105	COG1428	Deoxynucleoside kinase
FHK66_RS09110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FHK66_RS09125	COG1304	FMN binding
FHK66_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
FHK66_RS09155	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FHK66_RS09160	COG1012	belongs to the aldehyde dehydrogenase family
FHK66_RS09160	COG1454	alcohol dehydrogenase
FHK66_RS09170	COG1862	Preprotein translocase
FHK66_RS09175	COG0343	queuine tRNA-ribosyltransferase activity
FHK66_RS09190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FHK66_RS09210	COG1174	glycine betaine transport
FHK66_RS09240	COG0531	amino acid
FHK66_RS09255	COG3321	synthase
FHK66_RS09255	COG0604	alcohol dehydrogenase
FHK66_RS09260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FHK66_RS09270	COG2337	Toxic component of a toxin-antitoxin (TA) module
FHK66_RS09275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FHK66_RS09280	COG0736	holo-[acyl-carrier-protein] synthase activity
FHK66_RS09290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FHK66_RS09295	COG1181	Belongs to the D-alanine--D-alanine ligase family
FHK66_RS09305	COG1671	Belongs to the UPF0178 family
FHK66_RS09335	COG0572	uridine kinase
FHK66_RS09340	COG1011	Hydrolase
FHK66_RS09345	COG1187	pseudouridine synthase activity
FHK66_RS09350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FHK66_RS09360	COG0534	Mate efflux family protein
FHK66_RS09365	COG1253	flavin adenine dinucleotide binding
FHK66_RS09370	COG3158	transport of potassium into the cell
FHK66_RS09390	COG1185	polyribonucleotide nucleotidyltransferase activity
FHK66_RS09395	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FHK66_RS09400	COG0242	peptide deformylase activity
FHK66_RS09410	COG1827	regulation of RNA biosynthetic process
FHK66_RS09415	COG0110	maltose O-acetyltransferase activity
FHK66_RS09420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FHK66_RS09435	COG0765	amino acid transport
FHK66_RS09440	COG1126	abc transporter atp-binding protein
FHK66_RS09445	COG1113	amino acid transport
FHK66_RS09455	COG1114	Component of the transport system for branched-chain amino acids
FHK66_RS09460	COG2826	transposase and inactivated derivatives, IS30 family
FHK66_RS09470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FHK66_RS09480	COG2255	four-way junction helicase activity
FHK66_RS09485	COG0632	four-way junction helicase activity
FHK66_RS09495	COG2188	Transcriptional regulator
FHK66_RS09500	COG1263	PTS System
FHK66_RS09500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS09505	COG0424	maF-like protein
FHK66_RS09515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FHK66_RS09525	COG1692	metallophosphoesterase
FHK66_RS09535	COG0561	phosphatase activity
FHK66_RS09550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FHK66_RS09555	COG1268	BioY protein
FHK66_RS09565	COG1028	Short-chain dehydrogenase reductase Sdr
FHK66_RS09635	COG4607	ABC-type enterochelin transport system periplasmic component
FHK66_RS09640	COG4604	ABC transporter, ATP-binding protein
FHK66_RS09645	COG4605	iron ion homeostasis
FHK66_RS09650	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FHK66_RS09660	COG1181	Belongs to the D-alanine--D-alanine ligase family
FHK66_RS09660	COG2918	glutathione biosynthetic process
FHK66_RS09670	COG0552	protein localization to endoplasmic reticulum
FHK66_RS09675	COG0561	phosphatase activity
FHK66_RS09680	COG1196	nuclear chromosome segregation
FHK66_RS09685	COG0571	ribonuclease III activity
FHK66_RS09700	COG0601	transmembrane transport
FHK66_RS09705	COG4608	Belongs to the ABC transporter superfamily
FHK66_RS09715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FHK66_RS09720	COG0416	fatty acid biosynthetic process
FHK66_RS09725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FHK66_RS09730	COG1461	Dihydroxyacetone kinase
FHK66_RS09745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FHK66_RS09780	COG3328	transposase activity
FHK66_RS09800	COG0101	tRNA pseudouridine synthase activity
FHK66_RS09810	COG1122	ATPase activity
FHK66_RS09815	COG1122	ATPase activity
FHK66_RS09820	COG0203	ribosomal protein L17
FHK66_RS09825	COG0202	RNA polymerase activity
FHK66_RS09830	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FHK66_RS09835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FHK66_RS09840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FHK66_RS09845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FHK66_RS09850	COG0563	adenylate kinase activity
FHK66_RS09855	COG0201	protein transport
FHK66_RS09860	COG0200	Binds to the 23S rRNA
FHK66_RS09865	COG1841	ribosomal large subunit assembly
FHK66_RS09870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FHK66_RS09875	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FHK66_RS09880	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FHK66_RS09885	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FHK66_RS09890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FHK66_RS09895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FHK66_RS09900	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FHK66_RS09905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FHK66_RS09910	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FHK66_RS09915	COG0255	Belongs to the universal ribosomal protein uL29 family
FHK66_RS09920	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FHK66_RS09925	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FHK66_RS09930	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FHK66_RS09940	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FHK66_RS09945	COG0089	rRNA binding
FHK66_RS09950	COG0088	Forms part of the polypeptide exit tunnel
FHK66_RS09955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FHK66_RS09960	COG0051	transcription antitermination factor activity, RNA binding
FHK66_RS09965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FHK66_RS09970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FHK66_RS09975	COG0049	tRNA binding
FHK66_RS09980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FHK66_RS09985	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FHK66_RS09995	COG0588	phosphoglycerate mutase activity
FHK66_RS10005	COG0813	purine-nucleoside phosphorylase activity
FHK66_RS10015	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FHK66_RS10020	COG1079	Belongs to the binding-protein-dependent transport system permease family
FHK66_RS10025	COG4603	Belongs to the binding-protein-dependent transport system permease family
FHK66_RS10030	COG3845	ABC transporter
FHK66_RS10035	COG1744	ABC transporter substrate-binding protein PnrA-like
FHK66_RS10040	COG0295	cytidine deaminase activity
FHK66_RS10045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FHK66_RS10050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FHK66_RS10055	COG1609	Transcriptional regulator
FHK66_RS10060	COG2813	Specifically methylates the guanine in position
FHK66_RS10065	COG1072	(Pantothenic acid kinase))
FHK66_RS10070	COG0519	Catalyzes the synthesis of GMP from XMP
FHK66_RS10070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FHK66_RS10075	COG0582	viral genome integration into host DNA
FHK66_RS10085	COG3328	transposase activity
FHK66_RS10100	COG2826	transposase and inactivated derivatives, IS30 family
FHK66_RS10105	COG2814	Major facilitator Superfamily
FHK66_RS10135	COG0028	Belongs to the TPP enzyme family
FHK66_RS10155	COG0488	(ABC) transporter
FHK66_RS10165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FHK66_RS10170	COG0305	Participates in initiation and elongation during chromosome replication
FHK66_RS10175	COG0359	binds to the 23S rRNA
FHK66_RS10185	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FHK66_RS10190	COG0629	single-stranded DNA binding
FHK66_RS10195	COG0360	Binds together with S18 to 16S ribosomal RNA
FHK66_RS10205	COG0187	DNA topoisomerase II activity
FHK66_RS10210	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FHK66_RS10215	COG2501	S4 domain
FHK66_RS10220	COG0592	DNA-directed DNA polymerase activity
FHK66_RS10225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FHK66_RS10235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FHK66_RS10240	COG0594	ribonuclease P activity
FHK66_RS10245	COG0706	membrane insertase activity
FHK66_RS10250	COG1847	R3H domain protein
FHK66_RS10260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FHK66_RS10265	COG0445	tRNA wobble uridine modification
FHK66_RS10270	COG0357	Ribosomal RNA small subunit methyltransferase G
FHK66_RS10275	COG1192	Involved in chromosome partitioning
FHK66_RS10280	COG1475	DNA binding
FHK66_RS10285	COG4481	Protein conserved in bacteria
FHK66_RS10290	COG0012	GTP binding
FHK66_RS10305	COG0517	IMP dehydrogenase activity
FHK66_RS10305	COG0516	GMP reductase activity
FHK66_RS10315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FHK66_RS10400	COG4463	regulation of RNA biosynthetic process
FHK66_RS10405	COG0542	response to heat
FHK66_RS10410	COG0826	peptidase U32
FHK66_RS10415	COG0826	peptidase U32
FHK66_RS10420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FHK66_RS10440	COG4939	FMN-binding domain protein
FHK66_RS10460	COG0142	geranyltranstransferase activity
FHK66_RS10475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FHK66_RS10475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FHK66_RS10490	COG4120	Belongs to the binding-protein-dependent transport system permease family
FHK66_RS10505	COG0085	RNA polymerase activity
FHK66_RS10510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FHK66_RS10515	COG1609	Transcriptional regulator
FHK66_RS10520	COG0366	Alpha amylase catalytic
FHK66_RS10525	COG1653	transport
FHK66_RS10530	COG1175	transmembrane transport
FHK66_RS10535	COG0395	ABC-type sugar transport system, permease component
FHK66_RS10540	COG1063	alcohol dehydrogenase
FHK66_RS10545	COG1082	Xylose isomerase domain protein TIM barrel
FHK66_RS10550	COG0673	inositol 2-dehydrogenase activity
FHK66_RS10555	COG1554	hydrolase, family 65, central catalytic
FHK66_RS10565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHK66_RS10570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FHK66_RS10580	COG1070	Carbohydrate kinase
FHK66_RS10585	COG0783	Belongs to the Dps family
FHK66_RS10590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FHK66_RS10595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FHK66_RS10680	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FHK66_RS10730	COG0745	RESPONSE REGULATOR receiver
FHK66_RS10735	COG2205	protein histidine kinase activity
FHK66_RS10740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FHK66_RS10750	COG1131	(ABC) transporter
FHK66_RS10755	COG0842	Transport permease protein
FHK66_RS10765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FHK66_RS10780	COG0604	alcohol dehydrogenase
FHK66_RS10795	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FHK66_RS10815	COG2207	Transcriptional regulator
FHK66_RS10815	COG3708	Transcriptional regulator
FHK66_RS10830	COG0702	epimerase
FHK66_RS10835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS10835	COG1263	PTS System
FHK66_RS10835	COG2190	(PTS) system
FHK66_RS10840	COG3711	transcriptional antiterminator
FHK66_RS10845	COG0583	DNA-binding transcription factor activity
FHK66_RS10855	COG4221	oxidoreductase activity
FHK66_RS10860	COG1705	Flagellar rod assembly protein muramidase FlgJ
FHK66_RS10860	COG1388	LysM domain
FHK66_RS10870	COG0778	Nitroreductase
FHK66_RS10900	COG2814	Major facilitator Superfamily
FHK66_RS10920	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FHK66_RS10925	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FHK66_RS10935	COG0756	dUTP diphosphatase activity
FHK66_RS10945	COG4956	integral membrane protein (PIN domain superfamily)
FHK66_RS10950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FHK66_RS10955	COG1045	serine acetyltransferase
FHK66_RS10960	COG0215	cysteine-tRNA ligase activity
FHK66_RS10965	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FHK66_RS10970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FHK66_RS10975	COG3688	RNA-binding protein containing a PIN domain
FHK66_RS10985	COG4466	Protein conserved in bacteria
FHK66_RS10990	COG2153	protein acetylation
FHK66_RS10995	COG1970	mechanosensitive ion channel activity
FHK66_RS11000	COG0612	Peptidase, M16
FHK66_RS11005	COG0612	Peptidase, M16
FHK66_RS11010	COG1426	Protein conserved in bacteria
FHK66_RS11020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FHK66_RS11025	COG1546	Belongs to the CinA family
FHK66_RS11025	COG1058	Belongs to the CinA family
FHK66_RS11030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FHK66_RS11035	COG1418	mRNA catabolic process
FHK66_RS11040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FHK66_RS11045	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FHK66_RS11045	COG0392	lysyltransferase activity
FHK66_RS11050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FHK66_RS11055	COG3443	Belongs to the bacterial solute-binding protein 9 family
FHK66_RS11055	COG0803	Belongs to the bacterial solute-binding protein 9 family
FHK66_RS11060	COG1121	(ABC) transporter
FHK66_RS11065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FHK66_RS11070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FHK66_RS11075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FHK66_RS11080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FHK66_RS11095	COG1752	Esterase of the alpha-beta hydrolase superfamily
FHK66_RS11105	COG1561	YicC-like family, N-terminal region
FHK66_RS11120	COG0194	GDP metabolic process
FHK66_RS11125	COG1758	RNA polymerase activity
FHK66_RS11130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FHK66_RS11135	COG0242	peptide deformylase activity
FHK66_RS11140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FHK66_RS11145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FHK66_RS11145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FHK66_RS11150	COG0631	protein serine/threonine phosphatase activity
FHK66_RS11155	COG0515	serine threonine protein kinase
FHK66_RS11155	COG2815	serine threonine protein kinase
FHK66_RS11160	COG1162	GTPase activity
FHK66_RS11165	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FHK66_RS11175	COG1792	Involved in formation and maintenance of cell shape
FHK66_RS11200	COG0217	transcriptional regulatory protein
FHK66_RS11210	COG0039	L-malate dehydrogenase activity
FHK66_RS11215	COG0193	aminoacyl-tRNA hydrolase activity
FHK66_RS11220	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FHK66_RS11225	COG2244	polysaccharide biosynthetic process
FHK66_RS11230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FHK66_RS11240	COG1098	S1 RNA binding domain
FHK66_RS11245	COG0037	tRNA processing
FHK66_RS11250	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FHK66_RS11260	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FHK66_RS11265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FHK66_RS11270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FHK66_RS11430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FHK66_RS11435	COG0477	Major facilitator Superfamily
FHK66_RS11450	COG1132	(ABC) transporter
FHK66_RS11455	COG1132	(ABC) transporter
FHK66_RS11460	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FHK66_RS11465	COG1242	4 iron, 4 sulfur cluster binding
FHK66_RS11470	COG0671	phosphoesterase, PA-phosphatase related
FHK66_RS11475	COG1388	LysM domain
FHK66_RS11475	COG1705	Flagellar rod assembly protein muramidase FlgJ
FHK66_RS11480	COG0495	leucyl-tRNA aminoacylation
FHK66_RS11500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS11500	COG3711	transcriptional antiterminator
FHK66_RS11515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHK66_RS11520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FHK66_RS11530	COG2244	polysaccharide biosynthetic process
FHK66_RS11535	COG1187	pseudouridine synthase activity
FHK66_RS11545	COG1175	transmembrane transport
FHK66_RS11550	COG0395	ABC-type sugar transport system, permease component
FHK66_RS11555	COG1653	transport
FHK66_RS11570	COG2972	Histidine kinase
FHK66_RS11575	COG2207	Transcriptional regulator
FHK66_RS11575	COG4753	response regulator
FHK66_RS11600	COG0383	alpha-mannosidase activity
FHK66_RS11605	COG1940	carbohydrate kinase activity
FHK66_RS11610	COG0564	pseudouridine synthase activity
FHK66_RS11615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FHK66_RS11620	COG3679	Belongs to the UPF0342 family
FHK66_RS11625	COG1132	(ABC) transporter
FHK66_RS11635	COG2755	lipolytic protein G-D-S-L family
FHK66_RS11640	COG1904	glucuronate isomerase
FHK66_RS11645	COG2721	sulfolactate sulfo-lyase activity
FHK66_RS11655	COG1609	Transcriptional regulator
FHK66_RS11660	COG2207	Transcriptional regulator
FHK66_RS11670	COG0395	ABC-type sugar transport system, permease component
FHK66_RS11675	COG4209	transmembrane transport
FHK66_RS11690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FHK66_RS11700	COG1073	alpha beta
FHK66_RS11715	COG3507	Belongs to the glycosyl hydrolase 43 family
FHK66_RS11725	COG2211	Major facilitator Superfamily
FHK66_RS11775	COG0420	3'-5' exonuclease activity
FHK66_RS11780	COG4717	serine-type aminopeptidase activity
FHK66_RS11785	COG3481	metal-dependent phosphohydrolase, HD sub domain
FHK66_RS11790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FHK66_RS11800	COG0537	adenosine 5'-monophosphoramidase activity
FHK66_RS11805	COG1131	(ABC) transporter
FHK66_RS11810	COG4473	ABC transporter
FHK66_RS11820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FHK66_RS11825	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FHK66_RS11830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FHK66_RS11835	COG1459	type II secretion system
FHK66_RS11840	COG4537	Required for transformation and DNA binding
FHK66_RS11865	COG0827	DNA restriction-modification system
FHK66_RS11870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FHK66_RS11875	COG0488	(ABC) transporter
FHK66_RS11885	COG0589	response to stress
FHK66_RS11900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FHK66_RS11905	COG2094	Belongs to the DNA glycosylase MPG family
FHK66_RS11915	COG2264	protein methyltransferase activity
FHK66_RS11920	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FHK66_RS11930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FHK66_RS11935	COG1490	D-aminoacyl-tRNA deacylase activity
FHK66_RS11945	COG2124	cytochrome p450
FHK66_RS11950	COG0667	Aldo Keto reductase
FHK66_RS11960	COG0124	histidyl-tRNA synthetase
FHK66_RS11965	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FHK66_RS11970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FHK66_RS11980	COG2827	Endonuclease containing a URI domain
FHK66_RS11985	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FHK66_RS11990	COG0204	Acyl-transferase
FHK66_RS11995	COG0420	3'-5' exonuclease activity
FHK66_RS12000	COG0419	ATPase involved in DNA repair
FHK66_RS12015	COG1393	Belongs to the ArsC family
FHK66_RS12020	COG4862	establishment of competence for transformation
FHK66_RS12040	COG4116	CYTH
FHK66_RS12045	COG2357	RelA SpoT domain protein
FHK66_RS12050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FHK66_RS12055	COG0564	pseudouridine synthase activity
FHK66_RS12060	COG2239	Acts as a magnesium transporter
FHK66_RS12070	COG3142	Participates in the control of copper homeostasis
FHK66_RS12075	COG2226	methyltransferase
FHK66_RS12080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FHK66_RS12090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FHK66_RS12100	COG2197	response regulator
FHK66_RS12105	COG4585	Histidine kinase
FHK66_RS12110	COG1131	(ABC) transporter
FHK66_RS12125	COG1597	lipid kinase activity
FHK66_RS12140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FHK66_RS12145	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FHK66_RS12150	COG0250	Participates in transcription elongation, termination and antitermination
FHK66_RS12155	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FHK66_RS12160	COG1304	FMN binding
FHK66_RS12165	COG1760	l-serine dehydratase
FHK66_RS12170	COG1760	l-serine dehydratase
FHK66_RS12175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FHK66_RS12180	COG0081	regulation of translation
FHK66_RS12185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FHK66_RS12190	COG0222	ribosome binding
FHK66_RS12195	COG0398	Pfam SNARE associated Golgi protein
FHK66_RS12200	COG2814	Major facilitator Superfamily
FHK66_RS12205	COG0488	(ABC) transporter
FHK66_RS12210	COG0363	glucosamine-6-phosphate deaminase activity
FHK66_RS12215	COG1285	pathogenesis
FHK66_RS12220	COG0628	permease
FHK66_RS12230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FHK66_RS12235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FHK66_RS12265	COG3448	diguanylate cyclase activity
FHK66_RS12265	COG4175	Glycine betaine
FHK66_RS12290	COG1278	Cold shock
FHK66_RS12305	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FHK66_RS12325	COG1307	EDD domain protein, DegV family
FHK66_RS12330	COG0745	RESPONSE REGULATOR receiver
FHK66_RS12335	COG5002	protein histidine kinase activity
FHK66_RS12350	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FHK66_RS12360	COG2910	NAD(P)H-binding
FHK66_RS12365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FHK66_RS12375	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FHK66_RS12380	COG0459	protein refolding
FHK66_RS12390	COG3328	transposase activity
FHK66_RS12400	COG1609	Transcriptional regulator
FHK66_RS12405	COG0789	Transcriptional regulator
FHK66_RS12420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FHK66_RS12425	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FHK66_RS12445	COG1175	transmembrane transport
FHK66_RS12450	COG0395	ABC-type sugar transport system, permease component
FHK66_RS12460	COG3534	alpha-L-arabinofuranosidase
FHK66_RS12465	COG3940	Belongs to the glycosyl hydrolase 43 family
FHK66_RS12485	COG0235	Class ii aldolase
FHK66_RS12490	COG2160	L-arabinose isomerase activity
FHK66_RS12495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FHK66_RS12505	COG1368	sulfuric ester hydrolase activity
FHK66_RS12515	COG2706	6-phosphogluconolactonase activity
FHK66_RS12525	COG0628	permease
FHK66_RS12530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FHK66_RS12550	COG1132	(ABC) transporter
FHK66_RS12570	COG1482	cell wall glycoprotein biosynthetic process
FHK66_RS12575	COG2213	PTS system mannitol-specific
FHK66_RS12580	COG3711	transcriptional antiterminator
FHK66_RS12585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS12595	COG1131	(ABC) transporter
FHK66_RS12600	COG2213	PTS system mannitol-specific
FHK66_RS12605	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS12610	COG0246	Mannitol dehydrogenase
FHK66_RS12615	COG3442	glutamine amidotransferase
FHK66_RS12620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FHK66_RS12625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FHK66_RS12645	COG0681	Belongs to the peptidase S26 family
FHK66_RS12650	COG2226	methyltransferase
FHK66_RS12660	COG1435	thymidine kinase activity
FHK66_RS12665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FHK66_RS12670	COG2890	protein-(glutamine-N5) methyltransferase activity
FHK66_RS12680	COG0009	L-threonylcarbamoyladenylate synthase
FHK66_RS12685	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FHK66_RS12695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FHK66_RS12730	COG0765	amino acid transport
FHK66_RS12735	COG1126	abc transporter atp-binding protein
FHK66_RS12740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FHK66_RS12745	COG2723	6-phospho-beta-galactosidase activity
FHK66_RS12750	COG1674	ftsk spoiiie
FHK66_RS12750	COG1280	lysine exporter protein (LysE YggA)
FHK66_RS12755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FHK66_RS12770	COG3328	transposase activity
FHK66_RS12790	COG4166	transmembrane transport
FHK66_RS12800	COG0601	transmembrane transport
FHK66_RS12805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FHK66_RS12810	COG0444	Belongs to the ABC transporter superfamily
FHK66_RS12815	COG4608	Belongs to the ABC transporter superfamily
FHK66_RS12820	COG0675	Transposase, IS605 OrfB family
FHK66_RS12840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FHK66_RS12840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FHK66_RS12845	COG3328	transposase activity
FHK66_RS12855	COG0531	amino acid
FHK66_RS12860	COG0084	hydrolase, TatD family'
FHK66_RS12865	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FHK66_RS12870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FHK66_RS12880	COG3842	ATPase activity
FHK66_RS12885	COG1803	Methylglyoxal synthase
FHK66_RS12895	COG1132	(ABC) transporter
FHK66_RS12900	COG1132	(ABC) transporter
FHK66_RS12930	COG3715	PTS system
FHK66_RS12935	COG3716	PTS system mannose fructose sorbose family IID component
FHK66_RS12940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FHK66_RS12945	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FHK66_RS12950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FHK66_RS12965	COG4821	SIS domain
FHK66_RS12975	COG1288	antiporter activity
FHK66_RS12980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FHK66_RS12990	COG1136	(ABC) transporter
FHK66_RS12995	COG0577	efflux transmembrane transporter activity
FHK66_RS13015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FHK66_RS13020	COG4109	DRTGG domain
FHK66_RS13025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FHK66_RS13030	COG2824	Alkylphosphonate utilization operon protein PhnA
FHK66_RS13035	COG2738	Putative neutral zinc metallopeptidase
FHK66_RS13055	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FHK66_RS13055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FHK66_RS13065	COG2508	Transcriptional regulator
FHK66_RS13070	COG0590	tRNA wobble adenosine to inosine editing
FHK66_RS13085	COG0737	Belongs to the 5'-nucleotidase family
FHK66_RS13090	COG4470	Protein conserved in bacteria
FHK66_RS13105	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FHK66_RS13110	COG0492	ferredoxin-NADP+ reductase activity
FHK66_RS13120	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FHK66_RS13125	COG1098	S1 RNA binding domain
FHK66_RS13175	COG3328	transposase activity
FHK66_RS13195	COG0504	CTP synthase activity
FHK66_RS13210	COG0789	Transcriptional regulator
FHK66_RS13215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FHK66_RS13220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FHK66_RS13225	COG0584	glycerophosphoryl diester phosphodiesterase
FHK66_RS13235	COG0740	serine-type endopeptidase activity
FHK66_RS13240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FHK66_RS13260	COG1132	(ABC) transporter
FHK66_RS13270	COG5503	Protein of unknown function (DUF1447)
FHK66_RS13285	COG1278	Cold shock
FHK66_RS13290	COG2003	Belongs to the UPF0758 family
FHK66_RS13295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHK66_RS13300	COG0285	dihydrofolate synthase activity
FHK66_RS13305	COG0525	valine-tRNA ligase activity
FHK66_RS13310	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FHK66_RS13315	COG0301	tRNA thio-modification
FHK66_RS13320	COG1104	cysteine desulfurase activity
FHK66_RS13325	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FHK66_RS13335	COG0561	phosphatase activity
FHK66_RS13340	COG1801	Protein of unknown function DUF72
FHK66_RS13360	COG3579	cysteine-type endopeptidase activity
FHK66_RS13410	COG1876	peptidase activity
FHK66_RS13415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FHK66_RS13420	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FHK66_RS13425	COG0254	rRNA binding
FHK66_RS13450	COG1349	DNA-binding transcription factor activity
FHK66_RS13465	COG2814	Major facilitator Superfamily
FHK66_RS13475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FHK66_RS13500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FHK66_RS13505	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FHK66_RS13510	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FHK66_RS13515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FHK66_RS13520	COG3870	Protein conserved in bacteria
FHK66_RS13525	COG0470	DNA polymerase III
FHK66_RS13530	COG1774	PSP1 C-terminal conserved region
FHK66_RS13535	COG4467	Involved in initiation control of chromosome replication
FHK66_RS13550	COG0602	queuosine metabolic process
FHK66_RS13555	COG1328	CTP reductase activity
FHK66_RS13560	COG1136	(ABC) transporter
FHK66_RS13565	COG0577	efflux transmembrane transporter activity
FHK66_RS13580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FHK66_RS13585	COG1696	Membrane protein involved in D-alanine export
FHK66_RS13590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FHK66_RS13595	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FHK66_RS13600	COG1363	Peptidase, m42
FHK66_RS13610	COG1234	tRNA 3'-trailer cleavage
FHK66_RS13615	COG0095	Lipoate-protein ligase
FHK66_RS13640	COG3759	membrane
FHK66_RS13645	COG0659	secondary active sulfate transmembrane transporter activity
FHK66_RS13655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FHK66_RS13665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FHK66_RS13715	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FHK66_RS13715	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FHK66_RS13720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS13720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FHK66_RS13730	COG3715	PTS system
FHK66_RS13735	COG3716	PTS system mannose fructose sorbose family IID component
FHK66_RS13745	COG2261	transglycosylase associated protein
FHK66_RS13755	COG0006	proline dipeptidase activity
FHK66_RS13805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FHK66_RS13900	COG1404	Belongs to the peptidase S8 family
FHK66_RS13935	COG2217	Heavy metal translocating P-type atpase
FHK66_RS13940	COG2217	Heavy metal translocating P-type atpase
FHK66_RS13955	COG1388	LysM domain
FHK66_RS13970	COG0745	RESPONSE REGULATOR receiver
FHK66_RS13975	COG2132	Multicopper oxidase
FHK66_RS13980	COG2217	Heavy metal translocating P-type atpase
FHK66_RS14010	COG0456	acetyltransferase
FHK66_RS14035	COG2217	Heavy metal translocating P-type atpase
FHK66_RS14040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FHK66_RS14050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FHK66_RS14055	COG0783	Belongs to the Dps family
FHK66_RS14060	COG3328	transposase activity
FHK66_RS14070	COG3328	transposase activity
FHK66_RS14110	COG4608	Belongs to the ABC transporter superfamily
FHK66_RS14130	COG2096	Adenosyltransferase
FHK66_RS14135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FHK66_RS14155	COG1288	antiporter activity
FHK66_RS14165	COG2188	Transcriptional regulator
FHK66_RS14170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FHK66_RS14175	COG2222	sugar isomerase
FHK66_RS14205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHK66_RS14210	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FHK66_RS14210	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FHK66_RS14215	COG2222	sugar isomerase
FHK66_RS14220	COG3716	PTS system mannose fructose sorbose family IID component
FHK66_RS14225	COG3715	PTS system
FHK66_RS14370	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FHK66_RS14375	COG1263	PTS System
FHK66_RS14375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS14375	COG2190	(PTS) system
FHK66_RS14380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS14380	COG1263	PTS System
FHK66_RS14380	COG2190	(PTS) system
FHK66_RS14445	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FHK66_RS14490	COG0366	Alpha amylase catalytic
FHK66_RS14495	COG1653	transport
FHK66_RS14500	COG1175	transmembrane transport
FHK66_RS14505	COG0395	ABC-type sugar transport system, permease component
FHK66_RS14520	COG0366	Alpha amylase catalytic
FHK66_RS14525	COG0366	Alpha amylase catalytic
FHK66_RS14530	COG0366	Alpha amylase catalytic
FHK66_RS14560	COG0488	(ABC) transporter
FHK66_RS14585	COG2226	methyltransferase
FHK66_RS14595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FHK66_RS14610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FHK66_RS14630	COG4974	Belongs to the 'phage' integrase family
FHK66_RS14645	COG1278	Cold shock
FHK66_RS14655	COG0582	viral genome integration into host DNA
FHK66_RS14700	COG3842	ATPase activity
FHK66_RS14710	COG0395	ABC-type sugar transport system, permease component
FHK66_RS14725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FHK66_RS14750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FHK66_RS14800	COG1263	PTS System
FHK66_RS14800	COG2190	(PTS) system
FHK66_RS14800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FHK66_RS14810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FHK66_RS14845	COG3328	transposase activity
FHK66_RS14850	COG3328	transposase activity
FHK66_RS14855	COG1028	Short-chain dehydrogenase reductase Sdr
FHK66_RS14860	COG0302	gtp cyclohydrolase
FHK66_RS14985	COG1192	Involved in chromosome partitioning
FHK66_RS15020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FHK66_RS15045	COG4115	mRNA cleavage
FHK66_RS15090	COG3344	reverse transcriptase
FHK66_RS15095	COG0629	single-stranded DNA binding
FHK66_RS15195	COG3344	reverse transcriptase