locus-tag	class	description
EfmKUHS13_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EfmKUHS13_RS00010	COG0592	DNA-directed DNA polymerase activity
EfmKUHS13_RS00015	COG2501	S4 domain
EfmKUHS13_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EfmKUHS13_RS00025	COG0187	DNA topoisomerase II activity
EfmKUHS13_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
EfmKUHS13_RS00040	COG0629	single-stranded DNA binding
EfmKUHS13_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EfmKUHS13_RS00055	COG0359	binds to the 23S rRNA
EfmKUHS13_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
EfmKUHS13_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EfmKUHS13_RS00075	COG0488	(ABC) transporter
EfmKUHS13_RS00085	COG0028	Belongs to the TPP enzyme family
EfmKUHS13_RS00150	COG2723	6-phospho-beta-galactosidase activity
EfmKUHS13_RS00160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EfmKUHS13_RS00160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EfmKUHS13_RS00170	COG3328	transposase activity
EfmKUHS13_RS00200	COG1674	ftsk spoiiie
EfmKUHS13_RS00205	COG2946	Replication initiation factor
EfmKUHS13_RS00250	COG0741	lytic transglycosylase activity
EfmKUHS13_RS00250	COG0791	NLP P60 protein
EfmKUHS13_RS00315	COG0582	viral genome integration into host DNA
EfmKUHS13_RS00320	COG0519	Catalyzes the synthesis of GMP from XMP
EfmKUHS13_RS00320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EfmKUHS13_RS00325	COG1072	(Pantothenic acid kinase))
EfmKUHS13_RS00330	COG2813	Specifically methylates the guanine in position
EfmKUHS13_RS00335	COG1609	Transcriptional regulator
EfmKUHS13_RS00340	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EfmKUHS13_RS00345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EfmKUHS13_RS00350	COG0295	cytidine deaminase activity
EfmKUHS13_RS00355	COG1744	ABC transporter substrate-binding protein PnrA-like
EfmKUHS13_RS00375	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EfmKUHS13_RS00390	COG0813	purine-nucleoside phosphorylase activity
EfmKUHS13_RS00395	COG0588	phosphoglycerate mutase activity
EfmKUHS13_RS00405	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EfmKUHS13_RS00410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EfmKUHS13_RS00415	COG0049	tRNA binding
EfmKUHS13_RS00420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EfmKUHS13_RS00425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EfmKUHS13_RS00430	COG0051	transcription antitermination factor activity, RNA binding
EfmKUHS13_RS00435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EfmKUHS13_RS00440	COG0088	Forms part of the polypeptide exit tunnel
EfmKUHS13_RS00445	COG0089	rRNA binding
EfmKUHS13_RS00450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EfmKUHS13_RS00460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EfmKUHS13_RS00465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EfmKUHS13_RS00470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EfmKUHS13_RS00475	COG0255	Belongs to the universal ribosomal protein uL29 family
EfmKUHS13_RS00480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EfmKUHS13_RS00485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EfmKUHS13_RS00490	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EfmKUHS13_RS00495	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EfmKUHS13_RS00500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EfmKUHS13_RS00505	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EfmKUHS13_RS00510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EfmKUHS13_RS00515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EfmKUHS13_RS00520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EfmKUHS13_RS00525	COG1841	ribosomal large subunit assembly
EfmKUHS13_RS00530	COG0200	Binds to the 23S rRNA
EfmKUHS13_RS00535	COG0201	protein transport
EfmKUHS13_RS00540	COG0563	adenylate kinase activity
EfmKUHS13_RS00545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EfmKUHS13_RS00550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EfmKUHS13_RS00555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EfmKUHS13_RS00560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EfmKUHS13_RS00565	COG0202	RNA polymerase activity
EfmKUHS13_RS00570	COG0203	ribosomal protein L17
EfmKUHS13_RS00575	COG1122	ATPase activity
EfmKUHS13_RS00580	COG1122	ATPase activity
EfmKUHS13_RS00590	COG0101	tRNA pseudouridine synthase activity
EfmKUHS13_RS00600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EfmKUHS13_RS00610	COG1461	Dihydroxyacetone kinase
EfmKUHS13_RS00615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EfmKUHS13_RS00620	COG0416	fatty acid biosynthetic process
EfmKUHS13_RS00625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EfmKUHS13_RS00640	COG4608	Belongs to the ABC transporter superfamily
EfmKUHS13_RS00645	COG0601	transmembrane transport
EfmKUHS13_RS00660	COG0571	ribonuclease III activity
EfmKUHS13_RS00665	COG1196	nuclear chromosome segregation
EfmKUHS13_RS00670	COG0561	phosphatase activity
EfmKUHS13_RS00675	COG0552	protein localization to endoplasmic reticulum
EfmKUHS13_RS00680	COG1181	Belongs to the D-alanine--D-alanine ligase family
EfmKUHS13_RS00680	COG2918	glutathione biosynthetic process
EfmKUHS13_RS00690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EfmKUHS13_RS00695	COG4605	iron ion homeostasis
EfmKUHS13_RS00700	COG4604	ABC transporter, ATP-binding protein
EfmKUHS13_RS00705	COG4607	ABC-type enterochelin transport system periplasmic component
EfmKUHS13_RS00730	COG4932	domain protein
EfmKUHS13_RS00730	COG4886	Leucine-rich repeat (LRR) protein
EfmKUHS13_RS00745	COG3328	transposase activity
EfmKUHS13_RS00765	COG1380	Effector of murein hydrolase LrgA
EfmKUHS13_RS00785	COG1028	Short-chain dehydrogenase reductase Sdr
EfmKUHS13_RS00795	COG1268	BioY protein
EfmKUHS13_RS00805	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EfmKUHS13_RS00820	COG0561	phosphatase activity
EfmKUHS13_RS00825	COG1692	metallophosphoesterase
EfmKUHS13_RS00835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EfmKUHS13_RS00845	COG0424	maF-like protein
EfmKUHS13_RS00850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS00850	COG1263	PTS System
EfmKUHS13_RS00855	COG2188	Transcriptional regulator
EfmKUHS13_RS00865	COG0632	four-way junction helicase activity
EfmKUHS13_RS00870	COG2255	four-way junction helicase activity
EfmKUHS13_RS00880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EfmKUHS13_RS00890	COG3328	transposase activity
EfmKUHS13_RS00895	COG1114	Component of the transport system for branched-chain amino acids
EfmKUHS13_RS00905	COG1113	amino acid transport
EfmKUHS13_RS00910	COG1126	abc transporter atp-binding protein
EfmKUHS13_RS00915	COG0765	amino acid transport
EfmKUHS13_RS00925	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EfmKUHS13_RS00930	COG0110	maltose O-acetyltransferase activity
EfmKUHS13_RS00935	COG1827	regulation of RNA biosynthetic process
EfmKUHS13_RS00940	COG0242	peptide deformylase activity
EfmKUHS13_RS00945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EfmKUHS13_RS00950	COG1185	polyribonucleotide nucleotidyltransferase activity
EfmKUHS13_RS00960	COG3158	transport of potassium into the cell
EfmKUHS13_RS00965	COG1253	flavin adenine dinucleotide binding
EfmKUHS13_RS00970	COG0534	Mate efflux family protein
EfmKUHS13_RS00980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EfmKUHS13_RS00985	COG1187	pseudouridine synthase activity
EfmKUHS13_RS00990	COG1011	Hydrolase
EfmKUHS13_RS00995	COG0572	uridine kinase
EfmKUHS13_RS01020	COG1671	Belongs to the UPF0178 family
EfmKUHS13_RS01030	COG1181	Belongs to the D-alanine--D-alanine ligase family
EfmKUHS13_RS01035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EfmKUHS13_RS01045	COG0736	holo-[acyl-carrier-protein] synthase activity
EfmKUHS13_RS01050	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EfmKUHS13_RS01055	COG2337	Toxic component of a toxin-antitoxin (TA) module
EfmKUHS13_RS01060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EfmKUHS13_RS01065	COG0604	alcohol dehydrogenase
EfmKUHS13_RS01065	COG3321	synthase
EfmKUHS13_RS01075	COG0531	amino acid
EfmKUHS13_RS01105	COG1174	glycine betaine transport
EfmKUHS13_RS01140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EfmKUHS13_RS01155	COG0343	queuine tRNA-ribosyltransferase activity
EfmKUHS13_RS01160	COG1862	Preprotein translocase
EfmKUHS13_RS01165	COG1012	belongs to the aldehyde dehydrogenase family
EfmKUHS13_RS01165	COG1454	alcohol dehydrogenase
EfmKUHS13_RS01170	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EfmKUHS13_RS01200	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EfmKUHS13_RS01205	COG1028	Short-chain dehydrogenase reductase Sdr
EfmKUHS13_RS01210	COG1304	FMN binding
EfmKUHS13_RS01225	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EfmKUHS13_RS01230	COG1428	Deoxynucleoside kinase
EfmKUHS13_RS01245	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EfmKUHS13_RS01250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EfmKUHS13_RS01255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EfmKUHS13_RS01295	COG0824	Thioesterase
EfmKUHS13_RS01300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EfmKUHS13_RS01335	COG1363	Peptidase, m42
EfmKUHS13_RS01340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EfmKUHS13_RS01345	COG0589	response to stress
EfmKUHS13_RS01350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EfmKUHS13_RS01355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EfmKUHS13_RS01360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EfmKUHS13_RS01375	COG1674	ftsk spoiiie
EfmKUHS13_RS01385	COG2946	Replication initiation factor
EfmKUHS13_RS01420	COG0791	NLP P60 protein
EfmKUHS13_RS01420	COG0741	lytic transglycosylase activity
EfmKUHS13_RS01465	COG3414	Phosphotransferase system galactitol-specific IIB component
EfmKUHS13_RS01470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS01515	COG1105	Belongs to the carbohydrate kinase PfkB family
EfmKUHS13_RS01520	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EfmKUHS13_RS01520	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EfmKUHS13_RS01520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS01525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS01525	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EfmKUHS13_RS01525	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EfmKUHS13_RS01530	COG3684	Belongs to the aldolase LacD family
EfmKUHS13_RS01545	COG2188	Transcriptional regulator
EfmKUHS13_RS01550	COG4807	Protein conserved in bacteria
EfmKUHS13_RS01560	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EfmKUHS13_RS01600	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
EfmKUHS13_RS01605	COG2190	(PTS) system
EfmKUHS13_RS01605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS01605	COG1263	PTS System
EfmKUHS13_RS01615	COG2190	(PTS) system
EfmKUHS13_RS01615	COG1263	PTS System
EfmKUHS13_RS01615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS01625	COG3328	transposase activity
EfmKUHS13_RS01655	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EfmKUHS13_RS01665	COG0101	tRNA pseudouridine synthase activity
EfmKUHS13_RS01680	COG2186	Transcriptional regulator
EfmKUHS13_RS01710	COG1447	Phosphotransferase system cellobiose-specific component IIA
EfmKUHS13_RS01730	COG1063	alcohol dehydrogenase
EfmKUHS13_RS01740	COG4716	Myosin-crossreactive antigen
EfmKUHS13_RS01790	COG1113	amino acid transport
EfmKUHS13_RS01795	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EfmKUHS13_RS01800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EfmKUHS13_RS01840	COG1051	belongs to the nudix hydrolase family
EfmKUHS13_RS01845	COG1846	Transcriptional regulator
EfmKUHS13_RS01870	COG2252	PERMEase
EfmKUHS13_RS01875	COG0366	Alpha amylase catalytic
EfmKUHS13_RS01880	COG2723	6-phospho-beta-galactosidase activity
EfmKUHS13_RS01890	COG2190	(PTS) system
EfmKUHS13_RS01890	COG1263	PTS System
EfmKUHS13_RS01890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS01895	COG2723	6-phospho-beta-galactosidase activity
EfmKUHS13_RS01910	COG1902	pentaerythritol trinitrate reductase activity
EfmKUHS13_RS01920	COG0446	pyridine nucleotide-disulphide oxidoreductase
EfmKUHS13_RS01930	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EfmKUHS13_RS01935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EfmKUHS13_RS01940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EfmKUHS13_RS01945	COG1193	negative regulation of DNA recombination
EfmKUHS13_RS01950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EfmKUHS13_RS01960	COG1937	Protein conserved in bacteria
EfmKUHS13_RS01965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EfmKUHS13_RS01970	COG0446	pyridine nucleotide-disulphide oxidoreductase
EfmKUHS13_RS01975	COG3973	AAA domain
EfmKUHS13_RS02010	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EfmKUHS13_RS02015	COG2376	Dihydroxyacetone kinase
EfmKUHS13_RS02020	COG1461	Dihydroxyacetone kinase
EfmKUHS13_RS02035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EfmKUHS13_RS02045	COG1131	(ABC) transporter
EfmKUHS13_RS02070	COG0531	amino acid
EfmKUHS13_RS02085	COG1609	Transcriptional regulator
EfmKUHS13_RS02095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EfmKUHS13_RS02130	COG3479	Phenolic acid decarboxylase
EfmKUHS13_RS02135	COG1695	Transcriptional regulator
EfmKUHS13_RS02145	COG2814	Major facilitator Superfamily
EfmKUHS13_RS02165	COG0163	prenyltransferase activity
EfmKUHS13_RS02170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EfmKUHS13_RS02180	COG1136	(ABC) transporter
EfmKUHS13_RS02180	COG0577	efflux transmembrane transporter activity
EfmKUHS13_RS02190	COG5002	protein histidine kinase activity
EfmKUHS13_RS02200	COG1811	Na channel or pump
EfmKUHS13_RS02235	COG1136	(ABC) transporter
EfmKUHS13_RS02260	COG1705	Flagellar rod assembly protein muramidase FlgJ
EfmKUHS13_RS02260	COG3942	CHAP domain
EfmKUHS13_RS02265	COG2190	(PTS) system
EfmKUHS13_RS02265	COG1263	PTS System
EfmKUHS13_RS02265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS02270	COG1869	D-ribose catabolic process
EfmKUHS13_RS02300	COG0366	Alpha amylase catalytic
EfmKUHS13_RS02305	COG0628	permease
EfmKUHS13_RS02310	COG3443	Belongs to the bacterial solute-binding protein 9 family
EfmKUHS13_RS02310	COG0803	Belongs to the bacterial solute-binding protein 9 family
EfmKUHS13_RS02335	COG1428	Deoxynucleoside kinase
EfmKUHS13_RS02350	COG3328	transposase activity
EfmKUHS13_RS02355	COG1393	Belongs to the ArsC family
EfmKUHS13_RS02360	COG1393	Belongs to the ArsC family
EfmKUHS13_RS02380	COG0386	Belongs to the glutathione peroxidase family
EfmKUHS13_RS02385	COG1854	S-ribosylhomocysteine lyase activity
EfmKUHS13_RS02390	COG0626	cystathionine gamma-synthase activity
EfmKUHS13_RS02400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EfmKUHS13_RS02405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EfmKUHS13_RS02410	COG0019	diaminopimelate decarboxylase activity
EfmKUHS13_RS02415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EfmKUHS13_RS02425	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EfmKUHS13_RS02430	COG2171	N-acyltransferase activity
EfmKUHS13_RS02435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EfmKUHS13_RS02440	COG0527	aspartate kinase activity
EfmKUHS13_RS02445	COG1473	amidohydrolase
EfmKUHS13_RS02450	COG0436	Aminotransferase
EfmKUHS13_RS02455	COG0446	pyridine nucleotide-disulphide oxidoreductase
EfmKUHS13_RS02475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EfmKUHS13_RS02480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EfmKUHS13_RS02495	COG2207	Transcriptional regulator
EfmKUHS13_RS02500	COG2249	NAD(P)H dehydrogenase (quinone) activity
EfmKUHS13_RS02510	COG1113	amino acid transport
EfmKUHS13_RS02515	COG1121	(ABC) transporter
EfmKUHS13_RS02520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EfmKUHS13_RS02535	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EfmKUHS13_RS02540	COG1652	LysM domain
EfmKUHS13_RS02540	COG2823	Periplasmic or secreted lipoprotein
EfmKUHS13_RS02550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EfmKUHS13_RS02555	COG0477	Major facilitator Superfamily
EfmKUHS13_RS02565	COG1438	arginine binding
EfmKUHS13_RS02580	COG1764	response to oxidative stress
EfmKUHS13_RS02585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EfmKUHS13_RS02590	COG1335	isochorismatase
EfmKUHS13_RS02600	COG2135	peptidase activity
EfmKUHS13_RS02645	COG0745	RESPONSE REGULATOR receiver
EfmKUHS13_RS02650	COG2205	protein histidine kinase activity
EfmKUHS13_RS02655	COG4975	Glucose uptake
EfmKUHS13_RS02660	COG0531	amino acid
EfmKUHS13_RS02665	COG3853	Toxic anion resistance protein (TelA)
EfmKUHS13_RS02685	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EfmKUHS13_RS02690	COG1335	isochorismatase
EfmKUHS13_RS02700	COG3590	peptidase
EfmKUHS13_RS02710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EfmKUHS13_RS02715	COG1104	cysteine desulfurase activity
EfmKUHS13_RS02735	COG0482	sulfurtransferase activity
EfmKUHS13_RS02745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EfmKUHS13_RS02750	COG2814	Major facilitator Superfamily
EfmKUHS13_RS02770	COG0463	Glycosyl transferase, family 2
EfmKUHS13_RS02775	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EfmKUHS13_RS02780	COG2855	membrane
EfmKUHS13_RS02790	COG0583	DNA-binding transcription factor activity
EfmKUHS13_RS02795	COG0772	Belongs to the SEDS family
EfmKUHS13_RS02800	COG1393	Belongs to the ArsC family
EfmKUHS13_RS02805	COG0509	glycine decarboxylation via glycine cleavage system
EfmKUHS13_RS02810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EfmKUHS13_RS02815	COG2011	ABC-type metal ion transport system permease component
EfmKUHS13_RS02820	COG1464	Belongs to the NlpA lipoprotein family
EfmKUHS13_RS02830	COG0719	Fe-S assembly protein
EfmKUHS13_RS02835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EfmKUHS13_RS02845	COG0719	Fe-S assembly protein
EfmKUHS13_RS02970	COG2190	(PTS) system
EfmKUHS13_RS02970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS02970	COG1263	PTS System
EfmKUHS13_RS02975	COG2723	6-phospho-beta-galactosidase activity
EfmKUHS13_RS02980	COG3711	transcriptional antiterminator
EfmKUHS13_RS03000	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EfmKUHS13_RS03015	COG1136	(ABC) transporter
EfmKUHS13_RS03015	COG0577	efflux transmembrane transporter activity
EfmKUHS13_RS03025	COG3328	transposase activity
EfmKUHS13_RS03030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EfmKUHS13_RS03040	COG1597	lipid kinase activity
EfmKUHS13_RS03075	COG1733	regulation of RNA biosynthetic process
EfmKUHS13_RS03085	COG3764	Sortase (surface protein transpeptidase)
EfmKUHS13_RS03090	COG3711	transcriptional antiterminator
EfmKUHS13_RS03095	COG1263	PTS System
EfmKUHS13_RS03095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS03095	COG2190	(PTS) system
EfmKUHS13_RS03100	COG2723	6-phospho-beta-galactosidase activity
EfmKUHS13_RS03105	COG2188	Transcriptional regulator
EfmKUHS13_RS03115	COG1611	Belongs to the LOG family
EfmKUHS13_RS03125	COG1428	Deoxynucleoside kinase
EfmKUHS13_RS03140	COG2723	6-phospho-beta-galactosidase activity
EfmKUHS13_RS03150	COG1368	sulfuric ester hydrolase activity
EfmKUHS13_RS03160	COG0105	UTP biosynthetic process
EfmKUHS13_RS03165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EfmKUHS13_RS03170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EfmKUHS13_RS03175	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EfmKUHS13_RS03180	COG2011	ABC-type metal ion transport system permease component
EfmKUHS13_RS03185	COG1464	Belongs to the NlpA lipoprotein family
EfmKUHS13_RS03190	COG1473	amidohydrolase
EfmKUHS13_RS03205	COG1113	amino acid transport
EfmKUHS13_RS03215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EfmKUHS13_RS03220	COG1929	Belongs to the glycerate kinase type-1 family
EfmKUHS13_RS03225	COG0488	(ABC) transporter
EfmKUHS13_RS03240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EfmKUHS13_RS03245	COG1263	PTS System
EfmKUHS13_RS03245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS03270	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EfmKUHS13_RS03275	COG1131	(ABC) transporter
EfmKUHS13_RS03295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EfmKUHS13_RS03310	COG0346	lactoylglutathione lyase activity
EfmKUHS13_RS03335	COG0561	phosphatase activity
EfmKUHS13_RS03340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EfmKUHS13_RS03345	COG0280	phosphate acetyltransferase
EfmKUHS13_RS03350	COG0802	atpase or kinase
EfmKUHS13_RS03355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EfmKUHS13_RS03365	COG0708	Exodeoxyribonuclease III
EfmKUHS13_RS03375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EfmKUHS13_RS03400	COG1053	succinate dehydrogenase
EfmKUHS13_RS03405	COG3321	synthase
EfmKUHS13_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
EfmKUHS13_RS03405	COG0604	alcohol dehydrogenase
EfmKUHS13_RS03410	COG0702	epimerase
EfmKUHS13_RS03415	COG4684	Psort location CytoplasmicMembrane, score
EfmKUHS13_RS03420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EfmKUHS13_RS03425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EfmKUHS13_RS03430	COG0604	alcohol dehydrogenase
EfmKUHS13_RS03440	COG3842	ATPase activity
EfmKUHS13_RS03445	COG1176	ABC-type spermidine putrescine transport system, permease component I
EfmKUHS13_RS03450	COG1177	transmembrane transport
EfmKUHS13_RS03455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EfmKUHS13_RS03475	COG3715	PTS system
EfmKUHS13_RS03480	COG3716	PTS system mannose fructose sorbose family IID component
EfmKUHS13_RS03495	COG1940	carbohydrate kinase activity
EfmKUHS13_RS03530	COG0582	viral genome integration into host DNA
EfmKUHS13_RS03535	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EfmKUHS13_RS03545	COG0789	Transcriptional regulator
EfmKUHS13_RS03555	COG0504	CTP synthase activity
EfmKUHS13_RS03565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EfmKUHS13_RS03570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EfmKUHS13_RS03575	COG0254	rRNA binding
EfmKUHS13_RS03595	COG1349	DNA-binding transcription factor activity
EfmKUHS13_RS03605	COG2814	Major facilitator Superfamily
EfmKUHS13_RS03615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EfmKUHS13_RS03635	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EfmKUHS13_RS03640	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EfmKUHS13_RS03645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EfmKUHS13_RS03650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EfmKUHS13_RS03655	COG3870	Protein conserved in bacteria
EfmKUHS13_RS03660	COG0470	DNA polymerase III
EfmKUHS13_RS03665	COG1774	PSP1 C-terminal conserved region
EfmKUHS13_RS03670	COG4467	Involved in initiation control of chromosome replication
EfmKUHS13_RS03685	COG0602	queuosine metabolic process
EfmKUHS13_RS03690	COG1328	CTP reductase activity
EfmKUHS13_RS03695	COG1136	(ABC) transporter
EfmKUHS13_RS03700	COG0577	efflux transmembrane transporter activity
EfmKUHS13_RS03715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EfmKUHS13_RS03720	COG1696	Membrane protein involved in D-alanine export
EfmKUHS13_RS03725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EfmKUHS13_RS03730	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EfmKUHS13_RS03740	COG1363	Peptidase, m42
EfmKUHS13_RS03750	COG1234	tRNA 3'-trailer cleavage
EfmKUHS13_RS03755	COG0095	Lipoate-protein ligase
EfmKUHS13_RS03780	COG3759	membrane
EfmKUHS13_RS03785	COG0659	secondary active sulfate transmembrane transporter activity
EfmKUHS13_RS03795	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EfmKUHS13_RS03805	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EfmKUHS13_RS03810	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EfmKUHS13_RS03810	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EfmKUHS13_RS03815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS03815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS03825	COG3715	PTS system
EfmKUHS13_RS03830	COG3716	PTS system mannose fructose sorbose family IID component
EfmKUHS13_RS03840	COG2261	transglycosylase associated protein
EfmKUHS13_RS03845	COG0006	proline dipeptidase activity
EfmKUHS13_RS03850	COG1302	Protein conserved in bacteria
EfmKUHS13_RS03855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EfmKUHS13_RS03860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EfmKUHS13_RS03865	COG1570	exodeoxyribonuclease VII activity
EfmKUHS13_RS03870	COG1722	exodeoxyribonuclease VII activity
EfmKUHS13_RS03880	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EfmKUHS13_RS03885	COG1438	arginine binding
EfmKUHS13_RS03890	COG0497	DNA recombination
EfmKUHS13_RS03925	COG0768	penicillin binding
EfmKUHS13_RS03960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EfmKUHS13_RS03965	COG1799	cell septum assembly
EfmKUHS13_RS03975	COG2302	S4 RNA-binding domain
EfmKUHS13_RS03980	COG3599	regulation of cell shape
EfmKUHS13_RS03985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EfmKUHS13_RS03990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EfmKUHS13_RS04010	COG0673	inositol 2-dehydrogenase activity
EfmKUHS13_RS04015	COG0513	Belongs to the DEAD box helicase family
EfmKUHS13_RS04020	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EfmKUHS13_RS04020	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EfmKUHS13_RS04025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EfmKUHS13_RS04030	COG1447	Phosphotransferase system cellobiose-specific component IIA
EfmKUHS13_RS04035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EfmKUHS13_RS04090	COG1396	sequence-specific DNA binding
EfmKUHS13_RS04235	COG0740	serine-type endopeptidase activity
EfmKUHS13_RS04370	COG2309	aminopeptidase activity
EfmKUHS13_RS04380	COG0716	FMN binding
EfmKUHS13_RS04385	COG0024	Methionine aminopeptidase
EfmKUHS13_RS04390	COG1295	ribonuclease BN
EfmKUHS13_RS04395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EfmKUHS13_RS04410	COG1215	transferase activity, transferring glycosyl groups
EfmKUHS13_RS04415	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EfmKUHS13_RS04425	COG1088	dTDP-glucose 4,6-dehydratase activity
EfmKUHS13_RS04430	COG1091	dTDP-4-dehydrorhamnose reductase activity
EfmKUHS13_RS04445	COG1682	transport, permease protein
EfmKUHS13_RS04455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EfmKUHS13_RS04460	COG0438	transferase activity, transferring glycosyl groups
EfmKUHS13_RS04460	COG1216	Glycosyl transferase, family 2
EfmKUHS13_RS04470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EfmKUHS13_RS04475	COG1216	Glycosyl transferase, family 2
EfmKUHS13_RS04485	COG1216	Glycosyl transferase, family 2
EfmKUHS13_RS04485	COG1442	glycosyl transferase family 8
EfmKUHS13_RS04490	COG0463	Glycosyl transferase, family 2
EfmKUHS13_RS04490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EfmKUHS13_RS04525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EfmKUHS13_RS04550	COG4372	Transposase
EfmKUHS13_RS04555	COG3328	transposase activity
EfmKUHS13_RS04575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EfmKUHS13_RS04580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EfmKUHS13_RS04590	COG4585	Histidine kinase
EfmKUHS13_RS04600	COG0569	domain protein
EfmKUHS13_RS04625	COG2246	polysaccharide biosynthetic process
EfmKUHS13_RS04630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EfmKUHS13_RS04640	COG1316	TRANSCRIPTIONal
EfmKUHS13_RS04645	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EfmKUHS13_RS04650	COG3397	chitin binding
EfmKUHS13_RS04655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EfmKUHS13_RS04660	COG2137	regulation of response to DNA damage stimulus
EfmKUHS13_RS04665	COG1194	a g-specific adenine glycosylase
EfmKUHS13_RS04670	COG3557	Belongs to the UPF0374 family
EfmKUHS13_RS04685	COG1253	flavin adenine dinucleotide binding
EfmKUHS13_RS04690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EfmKUHS13_RS04705	COG0542	response to heat
EfmKUHS13_RS04710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS04715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EfmKUHS13_RS04725	COG0438	transferase activity, transferring glycosyl groups
EfmKUHS13_RS04730	COG2084	Dehydrogenase
EfmKUHS13_RS04735	COG4703	Protein of unknown function (DUF1797)
EfmKUHS13_RS04740	COG0322	excinuclease ABC activity
EfmKUHS13_RS04745	COG1846	Transcriptional regulator
EfmKUHS13_RS04750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EfmKUHS13_RS04760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EfmKUHS13_RS04770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EfmKUHS13_RS04780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EfmKUHS13_RS04785	COG0439	Biotin carboxylase
EfmKUHS13_RS04790	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EfmKUHS13_RS04795	COG0825	malonyl-CoA metabolic process
EfmKUHS13_RS04805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EfmKUHS13_RS04810	COG1534	Rna-binding protein
EfmKUHS13_RS04815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EfmKUHS13_RS04820	COG1713	HD superfamily hydrolase involved in NAD metabolism
EfmKUHS13_RS04825	COG0799	negative regulation of ribosome biogenesis
EfmKUHS13_RS04830	COG2226	methyltransferase
EfmKUHS13_RS04835	COG1323	Belongs to the UPF0348 family
EfmKUHS13_RS04840	COG0217	transcriptional regulatory protein
EfmKUHS13_RS04850	COG3973	AAA domain
EfmKUHS13_RS04855	COG2217	Heavy metal translocating P-type atpase
EfmKUHS13_RS04860	COG1942	4-Oxalocrotonate Tautomerase
EfmKUHS13_RS04865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EfmKUHS13_RS04870	COG1737	Transcriptional regulator
EfmKUHS13_RS04875	COG0768	penicillin binding
EfmKUHS13_RS04895	COG2252	PERMEase
EfmKUHS13_RS04900	COG2814	Major facilitator Superfamily
EfmKUHS13_RS04910	COG0587	DNA-directed DNA polymerase activity
EfmKUHS13_RS04915	COG0205	6-phosphofructokinase activity
EfmKUHS13_RS04925	COG0583	DNA-binding transcription factor activity
EfmKUHS13_RS04935	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EfmKUHS13_RS04940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EfmKUHS13_RS04945	COG0745	RESPONSE REGULATOR receiver
EfmKUHS13_RS04950	COG5002	protein histidine kinase activity
EfmKUHS13_RS05050	COG3711	transcriptional antiterminator
EfmKUHS13_RS05060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS05060	COG1263	PTS System
EfmKUHS13_RS05060	COG2190	(PTS) system
EfmKUHS13_RS05070	COG2190	(PTS) system
EfmKUHS13_RS05070	COG1263	PTS System
EfmKUHS13_RS05070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS05075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EfmKUHS13_RS05095	COG1349	DNA-binding transcription factor activity
EfmKUHS13_RS05120	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EfmKUHS13_RS05125	COG3623	hexulose-6-phosphate isomerase
EfmKUHS13_RS05135	COG0456	acetyltransferase
EfmKUHS13_RS05155	COG3711	transcriptional antiterminator
EfmKUHS13_RS05190	COG3964	amidohydrolase
EfmKUHS13_RS05205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EfmKUHS13_RS05205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS05205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EfmKUHS13_RS05210	COG3711	transcriptional antiterminator
EfmKUHS13_RS05210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS05215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EfmKUHS13_RS05220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EfmKUHS13_RS05225	COG0789	Transcriptional regulator
EfmKUHS13_RS05235	COG1105	Belongs to the carbohydrate kinase PfkB family
EfmKUHS13_RS05240	COG1349	DNA-binding transcription factor activity
EfmKUHS13_RS05245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS05260	COG3775	system Galactitol-specific IIC component
EfmKUHS13_RS05275	COG0400	carboxylic ester hydrolase activity
EfmKUHS13_RS05280	COG0346	lactoylglutathione lyase activity
EfmKUHS13_RS05285	COG2188	Transcriptional regulator
EfmKUHS13_RS05290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EfmKUHS13_RS05295	COG2723	6-phospho-beta-galactosidase activity
EfmKUHS13_RS05300	COG0589	response to stress
EfmKUHS13_RS05315	COG1393	Belongs to the ArsC family
EfmKUHS13_RS05325	COG0351	phosphomethylpyrimidine kinase
EfmKUHS13_RS05345	COG3425	synthase
EfmKUHS13_RS05350	COG0183	Belongs to the thiolase family
EfmKUHS13_RS05365	COG0656	L-ascorbic acid biosynthetic process
EfmKUHS13_RS05395	COG4372	Transposase
EfmKUHS13_RS05400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EfmKUHS13_RS05400	COG0392	lysyltransferase activity
EfmKUHS13_RS05405	COG0596	Alpha beta hydrolase
EfmKUHS13_RS05410	COG0741	lytic transglycosylase activity
EfmKUHS13_RS05420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EfmKUHS13_RS05425	COG0358	DNA primase activity
EfmKUHS13_RS05430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EfmKUHS13_RS05440	COG2996	Protein conserved in bacteria
EfmKUHS13_RS05445	COG0735	belongs to the Fur family
EfmKUHS13_RS05450	COG4974	Belongs to the 'phage' integrase family
EfmKUHS13_RS05460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EfmKUHS13_RS05465	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EfmKUHS13_RS05470	COG1187	pseudouridine synthase activity
EfmKUHS13_RS05475	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EfmKUHS13_RS05480	COG1288	antiporter activity
EfmKUHS13_RS05485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EfmKUHS13_RS05510	COG0514	ATP-dependent DNA helicase (RecQ)
EfmKUHS13_RS05520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EfmKUHS13_RS05525	COG0539	negative regulation of cytoplasmic translation
EfmKUHS13_RS05530	COG1160	GTP binding
EfmKUHS13_RS05535	COG0776	regulation of translation
EfmKUHS13_RS05545	COG0457	Tetratricopeptide repeat
EfmKUHS13_RS05550	COG5582	Belongs to the UPF0302 family
EfmKUHS13_RS05555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EfmKUHS13_RS05560	COG1694	Mazg nucleotide pyrophosphohydrolase
EfmKUHS13_RS05565	COG0617	tRNA 3'-terminal CCA addition
EfmKUHS13_RS05580	COG0025	NhaP-type Na H and K H
EfmKUHS13_RS05585	COG0488	(ABC) transporter
EfmKUHS13_RS05590	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EfmKUHS13_RS05600	COG1272	protein, Hemolysin III
EfmKUHS13_RS05605	COG1307	EDD domain protein, DegV family
EfmKUHS13_RS05610	COG2755	lipolytic protein G-D-S-L family
EfmKUHS13_RS05615	COG4698	Protein conserved in bacteria
EfmKUHS13_RS05625	COG4479	Belongs to the UPF0346 family
EfmKUHS13_RS05630	COG0681	Belongs to the peptidase S26 family
EfmKUHS13_RS05645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EfmKUHS13_RS05650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EfmKUHS13_RS05655	COG0758	DNA mediated transformation
EfmKUHS13_RS05660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EfmKUHS13_RS05665	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EfmKUHS13_RS05670	COG4974	Belongs to the 'phage' integrase family
EfmKUHS13_RS05675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EfmKUHS13_RS05680	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EfmKUHS13_RS05695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EfmKUHS13_RS05700	COG1832	CoA-binding protein
EfmKUHS13_RS05705	COG0187	DNA topoisomerase II activity
EfmKUHS13_RS05715	COG1882	Formate acetyltransferase
EfmKUHS13_RS05720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EfmKUHS13_RS05725	COG1227	inorganic diphosphatase activity
EfmKUHS13_RS05745	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EfmKUHS13_RS05755	COG1073	alpha beta
EfmKUHS13_RS05760	COG1609	Transcriptional regulator
EfmKUHS13_RS05770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EfmKUHS13_RS05780	COG1732	Glycine betaine
EfmKUHS13_RS05795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EfmKUHS13_RS05805	COG1116	anion transmembrane transporter activity
EfmKUHS13_RS05810	COG0084	hydrolase, TatD family'
EfmKUHS13_RS05815	COG1388	LysM domain
EfmKUHS13_RS05815	COG3942	CHAP domain
EfmKUHS13_RS05835	COG3328	transposase activity
EfmKUHS13_RS05850	COG0436	Aminotransferase
EfmKUHS13_RS05870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EfmKUHS13_RS05875	COG4565	transcriptional regulatory protein
EfmKUHS13_RS05880	COG3290	protein histidine kinase activity
EfmKUHS13_RS05885	COG3290	protein histidine kinase activity
EfmKUHS13_RS05895	COG2268	Band 7 protein
EfmKUHS13_RS05910	COG0673	inositol 2-dehydrogenase activity
EfmKUHS13_RS05920	COG1876	peptidase activity
EfmKUHS13_RS05925	COG1705	Flagellar rod assembly protein muramidase FlgJ
EfmKUHS13_RS05925	COG1388	LysM domain
EfmKUHS13_RS05935	COG1653	transport
EfmKUHS13_RS05940	COG1175	transmembrane transport
EfmKUHS13_RS05945	COG0395	ABC-type sugar transport system, permease component
EfmKUHS13_RS05955	COG0673	inositol 2-dehydrogenase activity
EfmKUHS13_RS05960	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EfmKUHS13_RS05965	COG2233	PERMEase
EfmKUHS13_RS05970	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EfmKUHS13_RS05975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EfmKUHS13_RS05980	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EfmKUHS13_RS05995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EfmKUHS13_RS06000	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EfmKUHS13_RS06005	COG0047	phosphoribosylformylglycinamidine synthase activity
EfmKUHS13_RS06010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EfmKUHS13_RS06020	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EfmKUHS13_RS06025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EfmKUHS13_RS06030	COG0138	bifunctional purine biosynthesis protein purh
EfmKUHS13_RS06035	COG0151	Belongs to the GarS family
EfmKUHS13_RS06040	COG4989	oxidoreductase activity
EfmKUHS13_RS06050	COG2972	Histidine kinase
EfmKUHS13_RS06060	COG4213	ABC transporter substrate-binding protein
EfmKUHS13_RS06070	COG4214	carbohydrate transport
EfmKUHS13_RS06075	COG0516	GMP reductase activity
EfmKUHS13_RS06080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EfmKUHS13_RS06090	COG0022	dehydrogenase e1 component
EfmKUHS13_RS06110	COG0483	inositol monophosphate 1-phosphatase activity
EfmKUHS13_RS06120	COG0514	ATP-dependent DNA helicase (RecQ)
EfmKUHS13_RS06125	COG4838	Belongs to the UPF0358 family
EfmKUHS13_RS06130	COG0772	Belongs to the SEDS family
EfmKUHS13_RS06135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EfmKUHS13_RS06150	COG4471	UPF0298 protein
EfmKUHS13_RS06155	COG0742	ribosomal rna small subunit methyltransferase
EfmKUHS13_RS06160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EfmKUHS13_RS06165	COG3480	Lon protease (S16) C-terminal proteolytic domain
EfmKUHS13_RS06170	COG1596	polysaccharide export
EfmKUHS13_RS06170	COG1555	photosystem II stabilization
EfmKUHS13_RS06185	COG2131	deaminase
EfmKUHS13_RS06190	COG0658	competence protein
EfmKUHS13_RS06190	COG2333	competence protein COMEC
EfmKUHS13_RS06195	COG1466	dna polymerase III delta subunit
EfmKUHS13_RS06200	COG0268	Binds directly to 16S ribosomal RNA
EfmKUHS13_RS06210	COG2707	UPF0756 membrane protein
EfmKUHS13_RS06215	COG2217	Heavy metal translocating P-type atpase
EfmKUHS13_RS06220	COG1968	undecaprenyl-diphosphatase activity
EfmKUHS13_RS06240	COG1666	GTP binding
EfmKUHS13_RS06245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EfmKUHS13_RS06250	COG2151	metal-sulfur cluster biosynthetic enzyme
EfmKUHS13_RS06265	COG1388	LysM domain
EfmKUHS13_RS06265	COG3942	CHAP domain
EfmKUHS13_RS06320	COG4990	cell redox homeostasis
EfmKUHS13_RS06340	COG3104	oligopeptide transport
EfmKUHS13_RS06350	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EfmKUHS13_RS06355	COG1074	ATP-dependent DNA helicase activity
EfmKUHS13_RS06360	COG1733	regulation of RNA biosynthetic process
EfmKUHS13_RS06365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EfmKUHS13_RS06370	COG0072	phenylalanine-tRNA ligase activity
EfmKUHS13_RS06370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EfmKUHS13_RS06385	COG1126	abc transporter atp-binding protein
EfmKUHS13_RS06390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EfmKUHS13_RS06395	COG0765	amino acid transport
EfmKUHS13_RS06400	COG0765	amino acid transport
EfmKUHS13_RS06405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EfmKUHS13_RS06410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EfmKUHS13_RS06420	COG0517	IMP dehydrogenase activity
EfmKUHS13_RS06425	COG0668	transmembrane transport
EfmKUHS13_RS06430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EfmKUHS13_RS06435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EfmKUHS13_RS06440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EfmKUHS13_RS06470	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EfmKUHS13_RS06480	COG1234	tRNA 3'-trailer cleavage
EfmKUHS13_RS06485	COG0300	oxidoreductase activity
EfmKUHS13_RS06490	COG5416	Lipopolysaccharide assembly protein A domain
EfmKUHS13_RS06495	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EfmKUHS13_RS06495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EfmKUHS13_RS06500	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EfmKUHS13_RS06515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EfmKUHS13_RS06530	COG2826	transposase and inactivated derivatives, IS30 family
EfmKUHS13_RS06540	COG1388	LysM domain
EfmKUHS13_RS06540	COG1705	Flagellar rod assembly protein muramidase FlgJ
EfmKUHS13_RS06545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EfmKUHS13_RS06550	COG0735	belongs to the Fur family
EfmKUHS13_RS06555	COG0446	pyridine nucleotide-disulphide oxidoreductase
EfmKUHS13_RS06570	COG1846	Transcriptional regulator
EfmKUHS13_RS06580	COG3935	DnaD domain protein
EfmKUHS13_RS06585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EfmKUHS13_RS06595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EfmKUHS13_RS06600	COG3331	DNA recombination
EfmKUHS13_RS06605	COG4474	Belongs to the UPF0398 family
EfmKUHS13_RS06610	COG3599	regulation of cell shape
EfmKUHS13_RS06620	COG0116	Belongs to the methyltransferase superfamily
EfmKUHS13_RS06625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EfmKUHS13_RS06630	COG1418	mRNA catabolic process
EfmKUHS13_RS06635	COG0156	8-amino-7-oxononanoate synthase activity
EfmKUHS13_RS06640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EfmKUHS13_RS06645	COG0531	amino acid
EfmKUHS13_RS06660	COG0513	Belongs to the DEAD box helicase family
EfmKUHS13_RS06665	COG2153	protein acetylation
EfmKUHS13_RS06670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EfmKUHS13_RS06675	COG4684	Psort location CytoplasmicMembrane, score
EfmKUHS13_RS06685	COG0328	RNA-DNA hybrid ribonuclease activity
EfmKUHS13_RS06695	COG1278	Cold shock
EfmKUHS13_RS06700	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EfmKUHS13_RS06715	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EfmKUHS13_RS06720	COG0564	pseudouridine synthase activity
EfmKUHS13_RS06730	COG2233	PERMEase
EfmKUHS13_RS06735	COG0540	Belongs to the ATCase OTCase family
EfmKUHS13_RS06740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EfmKUHS13_RS06745	COG0505	Belongs to the CarA family
EfmKUHS13_RS06750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EfmKUHS13_RS06755	COG0543	2 iron, 2 sulfur cluster binding
EfmKUHS13_RS06765	COG0284	orotidine-5'-phosphate decarboxylase activity
EfmKUHS13_RS06795	COG1293	RNA-binding protein homologous to eukaryotic snRNP
EfmKUHS13_RS06815	COG4120	Belongs to the binding-protein-dependent transport system permease family
EfmKUHS13_RS06825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EfmKUHS13_RS06860	COG0039	L-malate dehydrogenase activity
EfmKUHS13_RS06880	COG3037	sugar-specific permease SgaT UlaA
EfmKUHS13_RS06890	COG3711	transcriptional antiterminator
EfmKUHS13_RS06900	COG0673	inositol 2-dehydrogenase activity
EfmKUHS13_RS06950	COG0745	RESPONSE REGULATOR receiver
EfmKUHS13_RS06955	COG5002	protein histidine kinase activity
EfmKUHS13_RS06960	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
EfmKUHS13_RS06970	COG0318	PFAM AMP-dependent synthetase and ligase
EfmKUHS13_RS06980	COG0351	phosphomethylpyrimidine kinase
EfmKUHS13_RS06990	COG4475	Protein of unknown function (DUF436)
EfmKUHS13_RS06995	COG0366	Alpha amylase catalytic
EfmKUHS13_RS07010	COG1307	EDD domain protein, DegV family
EfmKUHS13_RS07015	COG2244	polysaccharide biosynthetic process
EfmKUHS13_RS07065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EfmKUHS13_RS07070	COG0194	GDP metabolic process
EfmKUHS13_RS07090	COG0765	amino acid transport
EfmKUHS13_RS07105	COG0167	dihydroorotate dehydrogenase activity
EfmKUHS13_RS07115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EfmKUHS13_RS07125	COG3833	ABC-type maltose transport systems, permease component
EfmKUHS13_RS07130	COG1175	transmembrane transport
EfmKUHS13_RS07135	COG2182	Extracellular solute-binding protein
EfmKUHS13_RS07140	COG0366	Alpha amylase catalytic
EfmKUHS13_RS07145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EfmKUHS13_RS07155	COG1764	response to oxidative stress
EfmKUHS13_RS07160	COG1846	Transcriptional regulator
EfmKUHS13_RS07165	COG0628	permease
EfmKUHS13_RS07180	COG1312	Catalyzes the dehydration of D-mannonate
EfmKUHS13_RS07195	COG0450	alkyl hydroperoxide reductase
EfmKUHS13_RS07250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EfmKUHS13_RS07265	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EfmKUHS13_RS07280	COG0531	amino acid
EfmKUHS13_RS07285	COG0004	ammonium transporteR
EfmKUHS13_RS07310	COG2261	transglycosylase associated protein
EfmKUHS13_RS07330	COG3328	transposase activity
EfmKUHS13_RS07340	COG3655	Transcriptional regulator
EfmKUHS13_RS07350	COG2261	transglycosylase associated protein
EfmKUHS13_RS07370	COG1028	Short-chain dehydrogenase reductase Sdr
EfmKUHS13_RS07385	COG1442	glycosyl transferase family 8
EfmKUHS13_RS07390	COG1442	glycosyl transferase family 8
EfmKUHS13_RS07395	COG0561	phosphatase activity
EfmKUHS13_RS07420	COG1476	TRANSCRIPTIONal
EfmKUHS13_RS07435	COG1278	Cold shock
EfmKUHS13_RS07440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EfmKUHS13_RS07445	COG1312	Catalyzes the dehydration of D-mannonate
EfmKUHS13_RS07465	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS07470	COG3716	PTS system mannose fructose sorbose family IID component
EfmKUHS13_RS07480	COG3732	PTS system glucitol sorbitol-specific
EfmKUHS13_RS07485	COG3730	PTS system glucitol sorbitol-specific
EfmKUHS13_RS07495	COG3711	transcriptional antiterminator
EfmKUHS13_RS07495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS07530	COG3328	transposase activity
EfmKUHS13_RS07545	COG0481	GTPase activity
EfmKUHS13_RS07565	COG0542	response to heat
EfmKUHS13_RS07580	COG1597	lipid kinase activity
EfmKUHS13_RS07585	COG2195	Cleaves the N-terminal amino acid of tripeptides
EfmKUHS13_RS07590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EfmKUHS13_RS07595	COG2384	SAM-dependent methyltransferase
EfmKUHS13_RS07605	COG1484	DNA-dependent DNA replication
EfmKUHS13_RS07615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EfmKUHS13_RS07625	COG0237	dephospho-CoA kinase activity
EfmKUHS13_RS07630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EfmKUHS13_RS07635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EfmKUHS13_RS07635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EfmKUHS13_RS07655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EfmKUHS13_RS07660	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EfmKUHS13_RS07665	COG3091	SprT-like family
EfmKUHS13_RS07670	COG2183	response to ionizing radiation
EfmKUHS13_RS07705	COG0546	phosphoglycolate phosphatase activity
EfmKUHS13_RS07710	COG0588	phosphoglycerate mutase activity
EfmKUHS13_RS07760	COG2207	Transcriptional regulator
EfmKUHS13_RS07760	COG4753	response regulator
EfmKUHS13_RS07770	COG2972	Histidine kinase
EfmKUHS13_RS07775	COG0077	Prephenate dehydratase
EfmKUHS13_RS07780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EfmKUHS13_RS07785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EfmKUHS13_RS07790	COG0287	Prephenate dehydrogenase
EfmKUHS13_RS07795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EfmKUHS13_RS07805	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EfmKUHS13_RS07810	COG3250	beta-galactosidase activity
EfmKUHS13_RS07825	COG1609	Transcriptional regulator
EfmKUHS13_RS07835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EfmKUHS13_RS07850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EfmKUHS13_RS07855	COG1597	lipid kinase activity
EfmKUHS13_RS07860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EfmKUHS13_RS07865	COG0154	amidase activity
EfmKUHS13_RS07870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EfmKUHS13_RS07875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EfmKUHS13_RS07880	COG0210	DNA helicase
EfmKUHS13_RS07890	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EfmKUHS13_RS07890	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EfmKUHS13_RS07890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS07895	COG1105	Belongs to the carbohydrate kinase PfkB family
EfmKUHS13_RS07900	COG1349	DNA-binding transcription factor activity
EfmKUHS13_RS07915	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EfmKUHS13_RS07920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EfmKUHS13_RS07925	COG0544	peptidyl-prolyl cis-trans isomerase activity
EfmKUHS13_RS07935	COG1714	RDD family
EfmKUHS13_RS07950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EfmKUHS13_RS07955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EfmKUHS13_RS07990	COG1481	regulation of sporulation
EfmKUHS13_RS07995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EfmKUHS13_RS08000	COG1660	Displays ATPase and GTPase activities
EfmKUHS13_RS08015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EfmKUHS13_RS08020	COG0556	nucleotide-excision repair
EfmKUHS13_RS08025	COG0765	amino acid transport
EfmKUHS13_RS08030	COG1126	abc transporter atp-binding protein
EfmKUHS13_RS08040	COG0484	heat shock protein binding
EfmKUHS13_RS08050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EfmKUHS13_RS08055	COG1420	regulation of RNA biosynthetic process
EfmKUHS13_RS08060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EfmKUHS13_RS08085	COG0693	protein deglycase activity
EfmKUHS13_RS08100	COG1619	proteins homologs of microcin C7 resistance protein MccF
EfmKUHS13_RS08110	COG5646	InterPro IPR014922
EfmKUHS13_RS08120	COG4975	Glucose uptake
EfmKUHS13_RS08130	COG0196	riboflavin kinase activity
EfmKUHS13_RS08135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EfmKUHS13_RS08145	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EfmKUHS13_RS08150	COG1175	transmembrane transport
EfmKUHS13_RS08155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EfmKUHS13_RS08170	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EfmKUHS13_RS08175	COG0195	Participates in both transcription termination and antitermination
EfmKUHS13_RS08180	COG0779	Required for maturation of 30S ribosomal subunits
EfmKUHS13_RS08185	COG2176	DNA-directed DNA polymerase activity
EfmKUHS13_RS08195	COG0750	zinc metalloprotease
EfmKUHS13_RS08200	COG4589	Belongs to the CDS family
EfmKUHS13_RS08205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EfmKUHS13_RS08210	COG0233	cytoplasmic translational termination
EfmKUHS13_RS08215	COG0528	UMP kinase activity
EfmKUHS13_RS08220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EfmKUHS13_RS08225	COG0052	Belongs to the universal ribosomal protein uS2 family
EfmKUHS13_RS08230	COG1438	arginine binding
EfmKUHS13_RS08240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EfmKUHS13_RS08245	COG0018	arginyl-trna synthetase
EfmKUHS13_RS08260	COG2235	arginine
EfmKUHS13_RS08265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EfmKUHS13_RS08270	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EfmKUHS13_RS08275	COG0456	acetyltransferase
EfmKUHS13_RS08285	COG1214	PFAM Peptidase M22, glycoprotease
EfmKUHS13_RS08295	COG1609	Transcriptional regulator
EfmKUHS13_RS08300	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EfmKUHS13_RS08305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EfmKUHS13_RS08320	COG3189	MarR family transcriptional regulator
EfmKUHS13_RS08325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EfmKUHS13_RS08330	COG1940	carbohydrate kinase activity
EfmKUHS13_RS08345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EfmKUHS13_RS08350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EfmKUHS13_RS08355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EfmKUHS13_RS08360	COG1120	ATPase activity
EfmKUHS13_RS08375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EfmKUHS13_RS08380	COG4876	unkown
EfmKUHS13_RS08385	COG0367	asparagine synthase
EfmKUHS13_RS08390	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EfmKUHS13_RS08400	COG1309	transcriptional regulator
EfmKUHS13_RS08420	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EfmKUHS13_RS08430	COG0584	glycerophosphoryl diester phosphodiesterase
EfmKUHS13_RS08445	COG0166	Belongs to the GPI family
EfmKUHS13_RS08450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EfmKUHS13_RS08455	COG2081	HI0933 family
EfmKUHS13_RS08460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EfmKUHS13_RS08465	COG0710	3-dehydroquinate dehydratase activity
EfmKUHS13_RS08470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EfmKUHS13_RS08475	COG1368	sulfuric ester hydrolase activity
EfmKUHS13_RS08490	COG3850	Histidine kinase
EfmKUHS13_RS08490	COG5002	protein histidine kinase activity
EfmKUHS13_RS08495	COG0745	RESPONSE REGULATOR receiver
EfmKUHS13_RS08515	COG2826	transposase and inactivated derivatives, IS30 family
EfmKUHS13_RS08535	COG1956	GAF domain-containing protein
EfmKUHS13_RS08540	COG3527	Alpha-acetolactate decarboxylase
EfmKUHS13_RS08545	COG0028	Belongs to the TPP enzyme family
EfmKUHS13_RS08555	COG0395	ABC-type sugar transport system, permease component
EfmKUHS13_RS08560	COG1175	transmembrane transport
EfmKUHS13_RS08585	COG0335	large ribosomal subunit rRNA binding
EfmKUHS13_RS08590	COG0336	Belongs to the RNA methyltransferase TrmD family
EfmKUHS13_RS08595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EfmKUHS13_RS08605	COG1837	Belongs to the UPF0109 family
EfmKUHS13_RS08610	COG0228	four-way junction DNA binding
EfmKUHS13_RS08615	COG0431	NADPH-dependent FMN reductase
EfmKUHS13_RS08620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EfmKUHS13_RS08625	COG0519	Catalyzes the synthesis of GMP from XMP
EfmKUHS13_RS08630	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EfmKUHS13_RS08635	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EfmKUHS13_RS08645	COG0745	RESPONSE REGULATOR receiver
EfmKUHS13_RS08650	COG5002	protein histidine kinase activity
EfmKUHS13_RS08655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EfmKUHS13_RS08660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EfmKUHS13_RS08685	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EfmKUHS13_RS08725	COG0714	Associated with various cellular activities
EfmKUHS13_RS08740	COG2217	Heavy metal translocating P-type atpase
EfmKUHS13_RS08745	COG2217	Heavy metal translocating P-type atpase
EfmKUHS13_RS08750	COG2608	mercury ion transmembrane transporter activity
EfmKUHS13_RS08755	COG3682	Transcriptional regulator
EfmKUHS13_RS08765	COG0531	amino acid
EfmKUHS13_RS08770	COG2217	Heavy metal translocating P-type atpase
EfmKUHS13_RS08795	COG0017	Asparaginyl-tRNA synthetase
EfmKUHS13_RS08800	COG0436	Aminotransferase
EfmKUHS13_RS08810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EfmKUHS13_RS08810	COG1199	ATP-dependent helicase activity
EfmKUHS13_RS08815	COG1278	Cold shock
EfmKUHS13_RS08835	COG1686	Belongs to the peptidase S11 family
EfmKUHS13_RS08850	COG0038	chloride channel
EfmKUHS13_RS08865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EfmKUHS13_RS08870	COG1254	Belongs to the acylphosphatase family
EfmKUHS13_RS08875	COG0706	membrane insertase activity
EfmKUHS13_RS08915	COG4372	Transposase
EfmKUHS13_RS08945	COG2207	Transcriptional regulator
EfmKUHS13_RS08950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EfmKUHS13_RS08955	COG1482	cell wall glycoprotein biosynthetic process
EfmKUHS13_RS08960	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EfmKUHS13_RS08960	COG0662	Cupin 2, conserved barrel domain protein
EfmKUHS13_RS08965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EfmKUHS13_RS08975	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EfmKUHS13_RS09055	COG0438	transferase activity, transferring glycosyl groups
EfmKUHS13_RS09110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EfmKUHS13_RS09115	COG4464	protein tyrosine phosphatase activity
EfmKUHS13_RS09120	COG0489	protein tyrosine kinase activity
EfmKUHS13_RS09125	COG3944	biosynthesis protein
EfmKUHS13_RS09130	COG1316	TRANSCRIPTIONal
EfmKUHS13_RS09140	COG0751	glycine-tRNA ligase activity
EfmKUHS13_RS09145	COG0752	glycyl-tRNA synthetase alpha subunit
EfmKUHS13_RS09150	COG1381	Involved in DNA repair and RecF pathway recombination
EfmKUHS13_RS09155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EfmKUHS13_RS09160	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EfmKUHS13_RS09165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EfmKUHS13_RS09175	COG1702	phosphate starvation-inducible protein PhoH
EfmKUHS13_RS09180	COG1114	Component of the transport system for branched-chain amino acids
EfmKUHS13_RS09185	COG1610	YqeY-like protein
EfmKUHS13_RS09190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EfmKUHS13_RS09195	COG0735	belongs to the Fur family
EfmKUHS13_RS09200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EfmKUHS13_RS09205	COG0640	Transcriptional regulator
EfmKUHS13_RS09210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EfmKUHS13_RS09215	COG0492	ferredoxin-NADP+ reductase activity
EfmKUHS13_RS09220	COG2723	6-phospho-beta-galactosidase activity
EfmKUHS13_RS09225	COG1486	melibiose metabolic process
EfmKUHS13_RS09230	COG1737	Transcriptional regulator
EfmKUHS13_RS09240	COG3711	transcriptional antiterminator
EfmKUHS13_RS09245	COG1132	(ABC) transporter
EfmKUHS13_RS09250	COG1132	(ABC) transporter
EfmKUHS13_RS09255	COG3763	UPF0154 protein
EfmKUHS13_RS09260	COG1914	H( )-stimulated, divalent metal cation uptake system
EfmKUHS13_RS09270	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EfmKUHS13_RS09280	COG1609	Transcriptional regulator
EfmKUHS13_RS09290	COG4980	gas vesicle protein
EfmKUHS13_RS09300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EfmKUHS13_RS09305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EfmKUHS13_RS09310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EfmKUHS13_RS09315	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EfmKUHS13_RS09325	COG1950	PFAM Membrane protein of
EfmKUHS13_RS09350	COG0704	Plays a role in the regulation of phosphate uptake
EfmKUHS13_RS09355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EfmKUHS13_RS09360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EfmKUHS13_RS09365	COG0581	inorganic phosphate transmembrane transporter activity
EfmKUHS13_RS09370	COG0573	inorganic phosphate transmembrane transporter activity
EfmKUHS13_RS09375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EfmKUHS13_RS09380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EfmKUHS13_RS09385	COG2177	Part of the ABC transporter FtsEX involved in
EfmKUHS13_RS09390	COG2884	Cell division ATP-binding protein ftsE
EfmKUHS13_RS09400	COG0653	protein targeting
EfmKUHS13_RS09415	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EfmKUHS13_RS09420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EfmKUHS13_RS09430	COG1739	Uncharacterized protein family UPF0029
EfmKUHS13_RS09435	COG2188	Transcriptional regulator
EfmKUHS13_RS09455	COG1940	carbohydrate kinase activity
EfmKUHS13_RS09475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EfmKUHS13_RS09485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EfmKUHS13_RS09490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EfmKUHS13_RS09495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EfmKUHS13_RS09500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EfmKUHS13_RS09505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EfmKUHS13_RS09510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EfmKUHS13_RS09515	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EfmKUHS13_RS09520	COG0356	it plays a direct role in the translocation of protons across the membrane
EfmKUHS13_RS09530	COG1647	Serine aminopeptidase, S33
EfmKUHS13_RS09535	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EfmKUHS13_RS09540	COG2388	GCN5-related N-acetyl-transferase
EfmKUHS13_RS09550	COG1957	nucleoside hydrolase
EfmKUHS13_RS09560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EfmKUHS13_RS09570	COG0149	triose-phosphate isomerase activity
EfmKUHS13_RS09575	COG0126	phosphoglycerate kinase activity
EfmKUHS13_RS09585	COG2390	Transcriptional regulator
EfmKUHS13_RS09590	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EfmKUHS13_RS09610	COG1595	DNA-templated transcription, initiation
EfmKUHS13_RS09625	COG0095	Lipoate-protein ligase
EfmKUHS13_RS09630	COG1078	dGTPase activity
EfmKUHS13_RS09635	COG0561	phosphatase activity
EfmKUHS13_RS09640	COG0494	nUDIX hydrolase
EfmKUHS13_RS09645	COG0346	lactoylglutathione lyase activity
EfmKUHS13_RS09655	COG2423	ornithine cyclodeaminase activity
EfmKUHS13_RS09660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EfmKUHS13_RS09665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EfmKUHS13_RS09670	COG1394	ATPase activity, coupled to movement of substances
EfmKUHS13_RS09675	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
EfmKUHS13_RS09680	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
EfmKUHS13_RS09685	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
EfmKUHS13_RS09690	COG1527	subunit (C
EfmKUHS13_RS09695	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
EfmKUHS13_RS09700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EfmKUHS13_RS09705	COG1269	ATP hydrolysis coupled proton transport
EfmKUHS13_RS09715	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EfmKUHS13_RS09720	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
EfmKUHS13_RS09730	COG4152	abc transporter atp-binding protein
EfmKUHS13_RS09735	COG0322	excinuclease ABC activity
EfmKUHS13_RS09740	COG3118	belongs to the thioredoxin family
EfmKUHS13_RS09745	COG1193	negative regulation of DNA recombination
EfmKUHS13_RS09760	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EfmKUHS13_RS09775	COG1136	(ABC) transporter
EfmKUHS13_RS09785	COG0446	pyridine nucleotide-disulphide oxidoreductase
EfmKUHS13_RS09815	COG1304	FMN binding
EfmKUHS13_RS09825	COG0281	malic enzyme
EfmKUHS13_RS09865	COG4695	Portal protein
EfmKUHS13_RS09940	COG4974	Belongs to the 'phage' integrase family
EfmKUHS13_RS09945	COG3906	Belongs to the UPF0473 family
EfmKUHS13_RS09950	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EfmKUHS13_RS09955	COG4472	Bacterial protein of unknown function (DUF965)
EfmKUHS13_RS09985	COG4555	ABC transporter
EfmKUHS13_RS09995	COG3689	TIGRFAM TIGR03943 family protein
EfmKUHS13_RS10000	COG0701	Predicted permease
EfmKUHS13_RS10005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EfmKUHS13_RS10010	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EfmKUHS13_RS10015	COG0488	(ABC) transporter
EfmKUHS13_RS10020	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EfmKUHS13_RS10035	COG0395	ABC-type sugar transport system, permease component
EfmKUHS13_RS10055	COG0662	Cupin 2, conserved barrel domain protein
EfmKUHS13_RS10055	COG2207	Transcriptional regulator
EfmKUHS13_RS10060	COG0446	pyridine nucleotide-disulphide oxidoreductase
EfmKUHS13_RS10070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EfmKUHS13_RS10075	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EfmKUHS13_RS10080	COG0584	glycerophosphoryl diester phosphodiesterase
EfmKUHS13_RS10090	COG0740	serine-type endopeptidase activity
EfmKUHS13_RS10095	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EfmKUHS13_RS10105	COG1132	(ABC) transporter
EfmKUHS13_RS10125	COG1278	Cold shock
EfmKUHS13_RS10130	COG2003	Belongs to the UPF0758 family
EfmKUHS13_RS10135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EfmKUHS13_RS10140	COG0285	dihydrofolate synthase activity
EfmKUHS13_RS10145	COG0525	valine-tRNA ligase activity
EfmKUHS13_RS10150	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EfmKUHS13_RS10155	COG0301	tRNA thio-modification
EfmKUHS13_RS10160	COG1104	cysteine desulfurase activity
EfmKUHS13_RS10165	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EfmKUHS13_RS10175	COG0561	phosphatase activity
EfmKUHS13_RS10180	COG1801	Protein of unknown function DUF72
EfmKUHS13_RS10200	COG3579	cysteine-type endopeptidase activity
EfmKUHS13_RS10265	COG1098	S1 RNA binding domain
EfmKUHS13_RS10270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EfmKUHS13_RS10280	COG0492	ferredoxin-NADP+ reductase activity
EfmKUHS13_RS10285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EfmKUHS13_RS10300	COG4470	Protein conserved in bacteria
EfmKUHS13_RS10305	COG0737	Belongs to the 5'-nucleotidase family
EfmKUHS13_RS10320	COG0590	tRNA wobble adenosine to inosine editing
EfmKUHS13_RS10325	COG2508	Transcriptional regulator
EfmKUHS13_RS10335	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EfmKUHS13_RS10335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EfmKUHS13_RS10350	COG2738	Putative neutral zinc metallopeptidase
EfmKUHS13_RS10355	COG2824	Alkylphosphonate utilization operon protein PhnA
EfmKUHS13_RS10360	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EfmKUHS13_RS10365	COG4109	DRTGG domain
EfmKUHS13_RS10370	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EfmKUHS13_RS10385	COG0577	efflux transmembrane transporter activity
EfmKUHS13_RS10390	COG1136	(ABC) transporter
EfmKUHS13_RS10400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EfmKUHS13_RS10405	COG1288	antiporter activity
EfmKUHS13_RS10410	COG4821	SIS domain
EfmKUHS13_RS10430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EfmKUHS13_RS10435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EfmKUHS13_RS10440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EfmKUHS13_RS10445	COG3716	PTS system mannose fructose sorbose family IID component
EfmKUHS13_RS10450	COG3715	PTS system
EfmKUHS13_RS10475	COG1132	(ABC) transporter
EfmKUHS13_RS10480	COG1132	(ABC) transporter
EfmKUHS13_RS10490	COG1803	Methylglyoxal synthase
EfmKUHS13_RS10495	COG3842	ATPase activity
EfmKUHS13_RS10505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EfmKUHS13_RS10510	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EfmKUHS13_RS10515	COG0084	hydrolase, TatD family'
EfmKUHS13_RS10535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EfmKUHS13_RS10535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EfmKUHS13_RS10550	COG0675	Transposase, IS605 OrfB family
EfmKUHS13_RS10555	COG4608	Belongs to the ABC transporter superfamily
EfmKUHS13_RS10560	COG0444	Belongs to the ABC transporter superfamily
EfmKUHS13_RS10565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EfmKUHS13_RS10570	COG0601	transmembrane transport
EfmKUHS13_RS10595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EfmKUHS13_RS10600	COG1674	ftsk spoiiie
EfmKUHS13_RS10600	COG1280	lysine exporter protein (LysE YggA)
EfmKUHS13_RS10605	COG2723	6-phospho-beta-galactosidase activity
EfmKUHS13_RS10610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EfmKUHS13_RS10615	COG1126	abc transporter atp-binding protein
EfmKUHS13_RS10620	COG0765	amino acid transport
EfmKUHS13_RS10660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EfmKUHS13_RS10670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EfmKUHS13_RS10675	COG0009	L-threonylcarbamoyladenylate synthase
EfmKUHS13_RS10685	COG2890	protein-(glutamine-N5) methyltransferase activity
EfmKUHS13_RS10690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EfmKUHS13_RS10695	COG1435	thymidine kinase activity
EfmKUHS13_RS10705	COG2226	methyltransferase
EfmKUHS13_RS10715	COG0681	Belongs to the peptidase S26 family
EfmKUHS13_RS10735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EfmKUHS13_RS10745	COG3442	glutamine amidotransferase
EfmKUHS13_RS10750	COG0246	Mannitol dehydrogenase
EfmKUHS13_RS10755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS10760	COG2213	PTS system mannitol-specific
EfmKUHS13_RS10765	COG1131	(ABC) transporter
EfmKUHS13_RS10775	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS10780	COG3711	transcriptional antiterminator
EfmKUHS13_RS10785	COG2213	PTS system mannitol-specific
EfmKUHS13_RS10790	COG1482	cell wall glycoprotein biosynthetic process
EfmKUHS13_RS10805	COG1132	(ABC) transporter
EfmKUHS13_RS10825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EfmKUHS13_RS10830	COG0628	permease
EfmKUHS13_RS10840	COG2706	6-phosphogluconolactonase activity
EfmKUHS13_RS10850	COG1368	sulfuric ester hydrolase activity
EfmKUHS13_RS10860	COG2160	L-arabinose isomerase activity
EfmKUHS13_RS10865	COG0235	Class ii aldolase
EfmKUHS13_RS10885	COG3940	Belongs to the glycosyl hydrolase 43 family
EfmKUHS13_RS10890	COG3534	alpha-L-arabinofuranosidase
EfmKUHS13_RS10900	COG0395	ABC-type sugar transport system, permease component
EfmKUHS13_RS10905	COG1175	transmembrane transport
EfmKUHS13_RS10925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EfmKUHS13_RS10930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EfmKUHS13_RS10940	COG0789	Transcriptional regulator
EfmKUHS13_RS10945	COG1609	Transcriptional regulator
EfmKUHS13_RS10960	COG0459	protein refolding
EfmKUHS13_RS10965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EfmKUHS13_RS10975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EfmKUHS13_RS10980	COG2910	NAD(P)H-binding
EfmKUHS13_RS10985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EfmKUHS13_RS11000	COG5002	protein histidine kinase activity
EfmKUHS13_RS11005	COG0745	RESPONSE REGULATOR receiver
EfmKUHS13_RS11055	COG4175	Glycine betaine
EfmKUHS13_RS11055	COG3448	diguanylate cyclase activity
EfmKUHS13_RS11080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EfmKUHS13_RS11085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EfmKUHS13_RS11095	COG0628	permease
EfmKUHS13_RS11100	COG1285	pathogenesis
EfmKUHS13_RS11105	COG0363	glucosamine-6-phosphate deaminase activity
EfmKUHS13_RS11110	COG0488	(ABC) transporter
EfmKUHS13_RS11135	COG0222	ribosome binding
EfmKUHS13_RS11140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EfmKUHS13_RS11145	COG0081	regulation of translation
EfmKUHS13_RS11150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EfmKUHS13_RS11155	COG1760	l-serine dehydratase
EfmKUHS13_RS11160	COG1760	l-serine dehydratase
EfmKUHS13_RS11165	COG1304	FMN binding
EfmKUHS13_RS11170	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EfmKUHS13_RS11175	COG0250	Participates in transcription elongation, termination and antitermination
EfmKUHS13_RS11180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EfmKUHS13_RS11185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EfmKUHS13_RS11200	COG1597	lipid kinase activity
EfmKUHS13_RS11215	COG1131	(ABC) transporter
EfmKUHS13_RS11220	COG4585	Histidine kinase
EfmKUHS13_RS11225	COG2197	response regulator
EfmKUHS13_RS11235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EfmKUHS13_RS11245	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EfmKUHS13_RS11250	COG2226	methyltransferase
EfmKUHS13_RS11255	COG3142	Participates in the control of copper homeostasis
EfmKUHS13_RS11260	COG2239	Acts as a magnesium transporter
EfmKUHS13_RS11265	COG0564	pseudouridine synthase activity
EfmKUHS13_RS11270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EfmKUHS13_RS11275	COG2357	RelA SpoT domain protein
EfmKUHS13_RS11280	COG4116	CYTH
EfmKUHS13_RS11305	COG4862	establishment of competence for transformation
EfmKUHS13_RS11310	COG1393	Belongs to the ArsC family
EfmKUHS13_RS11325	COG0419	ATPase involved in DNA repair
EfmKUHS13_RS11330	COG0420	3'-5' exonuclease activity
EfmKUHS13_RS11335	COG0204	Acyl-transferase
EfmKUHS13_RS11340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EfmKUHS13_RS11345	COG2827	Endonuclease containing a URI domain
EfmKUHS13_RS11350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EfmKUHS13_RS11350	COG2755	lipolytic protein G-D-S-L family
EfmKUHS13_RS11355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EfmKUHS13_RS11360	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EfmKUHS13_RS11365	COG0124	histidyl-tRNA synthetase
EfmKUHS13_RS11370	COG0667	Aldo Keto reductase
EfmKUHS13_RS11375	COG2124	cytochrome p450
EfmKUHS13_RS11380	COG1490	D-aminoacyl-tRNA deacylase activity
EfmKUHS13_RS11390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EfmKUHS13_RS11395	COG2264	protein methyltransferase activity
EfmKUHS13_RS11405	COG2094	Belongs to the DNA glycosylase MPG family
EfmKUHS13_RS11410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EfmKUHS13_RS11425	COG0589	response to stress
EfmKUHS13_RS11435	COG0488	(ABC) transporter
EfmKUHS13_RS11440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EfmKUHS13_RS11445	COG0827	DNA restriction-modification system
EfmKUHS13_RS11470	COG4537	Required for transformation and DNA binding
EfmKUHS13_RS11475	COG1459	type II secretion system
EfmKUHS13_RS11480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EfmKUHS13_RS11485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EfmKUHS13_RS11490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EfmKUHS13_RS11500	COG4473	ABC transporter
EfmKUHS13_RS11505	COG1131	(ABC) transporter
EfmKUHS13_RS11510	COG0537	adenosine 5'-monophosphoramidase activity
EfmKUHS13_RS11525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EfmKUHS13_RS11530	COG3481	metal-dependent phosphohydrolase, HD sub domain
EfmKUHS13_RS11535	COG4717	serine-type aminopeptidase activity
EfmKUHS13_RS11540	COG0420	3'-5' exonuclease activity
EfmKUHS13_RS11545	COG0561	phosphatase activity
EfmKUHS13_RS11570	COG2211	Major facilitator Superfamily
EfmKUHS13_RS11590	COG1073	alpha beta
EfmKUHS13_RS11600	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EfmKUHS13_RS11605	COG1653	transport
EfmKUHS13_RS11615	COG4209	transmembrane transport
EfmKUHS13_RS11620	COG0395	ABC-type sugar transport system, permease component
EfmKUHS13_RS11625	COG2207	Transcriptional regulator
EfmKUHS13_RS11635	COG1609	Transcriptional regulator
EfmKUHS13_RS11640	COG0246	Mannitol dehydrogenase
EfmKUHS13_RS11645	COG2721	sulfolactate sulfo-lyase activity
EfmKUHS13_RS11650	COG1904	glucuronate isomerase
EfmKUHS13_RS11655	COG2755	lipolytic protein G-D-S-L family
EfmKUHS13_RS11665	COG1132	(ABC) transporter
EfmKUHS13_RS11670	COG3679	Belongs to the UPF0342 family
EfmKUHS13_RS11675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EfmKUHS13_RS11680	COG0564	pseudouridine synthase activity
EfmKUHS13_RS11685	COG1940	carbohydrate kinase activity
EfmKUHS13_RS11690	COG0383	alpha-mannosidase activity
EfmKUHS13_RS11710	COG2207	Transcriptional regulator
EfmKUHS13_RS11710	COG4753	response regulator
EfmKUHS13_RS11715	COG2972	Histidine kinase
EfmKUHS13_RS11730	COG0395	ABC-type sugar transport system, permease component
EfmKUHS13_RS11735	COG1175	transmembrane transport
EfmKUHS13_RS11740	COG1187	pseudouridine synthase activity
EfmKUHS13_RS11755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EfmKUHS13_RS11760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EfmKUHS13_RS11775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS11775	COG3711	transcriptional antiterminator
EfmKUHS13_RS11825	COG0789	Transcriptional regulator
EfmKUHS13_RS11825	COG4978	Transcriptional regulator
EfmKUHS13_RS11835	COG1132	(ABC) transporter
EfmKUHS13_RS11845	COG0495	leucyl-tRNA aminoacylation
EfmKUHS13_RS11850	COG1388	LysM domain
EfmKUHS13_RS11850	COG1705	Flagellar rod assembly protein muramidase FlgJ
EfmKUHS13_RS11855	COG0671	phosphoesterase, PA-phosphatase related
EfmKUHS13_RS11860	COG1242	4 iron, 4 sulfur cluster binding
EfmKUHS13_RS11865	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EfmKUHS13_RS11915	COG0582	viral genome integration into host DNA
EfmKUHS13_RS11920	COG3328	transposase activity
EfmKUHS13_RS11935	COG1132	(ABC) transporter
EfmKUHS13_RS11940	COG1132	(ABC) transporter
EfmKUHS13_RS11955	COG0477	Major facilitator Superfamily
EfmKUHS13_RS11960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EfmKUHS13_RS12115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EfmKUHS13_RS12120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EfmKUHS13_RS12125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EfmKUHS13_RS12140	COG0037	tRNA processing
EfmKUHS13_RS12145	COG1098	S1 RNA binding domain
EfmKUHS13_RS12155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EfmKUHS13_RS12165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EfmKUHS13_RS12170	COG0193	aminoacyl-tRNA hydrolase activity
EfmKUHS13_RS12175	COG0039	L-malate dehydrogenase activity
EfmKUHS13_RS12185	COG0217	transcriptional regulatory protein
EfmKUHS13_RS12210	COG1792	Involved in formation and maintenance of cell shape
EfmKUHS13_RS12220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EfmKUHS13_RS12225	COG1162	GTPase activity
EfmKUHS13_RS12230	COG2815	serine threonine protein kinase
EfmKUHS13_RS12230	COG0515	serine threonine protein kinase
EfmKUHS13_RS12235	COG0631	protein serine/threonine phosphatase activity
EfmKUHS13_RS12240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EfmKUHS13_RS12240	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EfmKUHS13_RS12245	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EfmKUHS13_RS12250	COG0242	peptide deformylase activity
EfmKUHS13_RS12255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EfmKUHS13_RS12260	COG1758	RNA polymerase activity
EfmKUHS13_RS12265	COG0194	GDP metabolic process
EfmKUHS13_RS12270	COG4372	Transposase
EfmKUHS13_RS12290	COG1561	YicC-like family, N-terminal region
EfmKUHS13_RS12300	COG1752	Esterase of the alpha-beta hydrolase superfamily
EfmKUHS13_RS12315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EfmKUHS13_RS12320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EfmKUHS13_RS12325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EfmKUHS13_RS12330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EfmKUHS13_RS12335	COG1121	(ABC) transporter
EfmKUHS13_RS12340	COG3443	Belongs to the bacterial solute-binding protein 9 family
EfmKUHS13_RS12340	COG0803	Belongs to the bacterial solute-binding protein 9 family
EfmKUHS13_RS12345	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EfmKUHS13_RS12350	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EfmKUHS13_RS12350	COG0392	lysyltransferase activity
EfmKUHS13_RS12355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EfmKUHS13_RS12360	COG1418	mRNA catabolic process
EfmKUHS13_RS12365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EfmKUHS13_RS12370	COG1546	Belongs to the CinA family
EfmKUHS13_RS12370	COG1058	Belongs to the CinA family
EfmKUHS13_RS12375	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EfmKUHS13_RS12385	COG0612	Peptidase, M16
EfmKUHS13_RS12390	COG0612	Peptidase, M16
EfmKUHS13_RS12395	COG1970	mechanosensitive ion channel activity
EfmKUHS13_RS12400	COG2153	protein acetylation
EfmKUHS13_RS12410	COG4466	Protein conserved in bacteria
EfmKUHS13_RS12420	COG3688	RNA-binding protein containing a PIN domain
EfmKUHS13_RS12425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EfmKUHS13_RS12430	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EfmKUHS13_RS12435	COG0215	cysteine-tRNA ligase activity
EfmKUHS13_RS12440	COG1045	serine acetyltransferase
EfmKUHS13_RS12445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EfmKUHS13_RS12450	COG4956	integral membrane protein (PIN domain superfamily)
EfmKUHS13_RS12460	COG0756	dUTP diphosphatase activity
EfmKUHS13_RS12465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EfmKUHS13_RS12470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EfmKUHS13_RS12505	COG0778	Nitroreductase
EfmKUHS13_RS12515	COG1388	LysM domain
EfmKUHS13_RS12515	COG1705	Flagellar rod assembly protein muramidase FlgJ
EfmKUHS13_RS12520	COG4221	oxidoreductase activity
EfmKUHS13_RS12530	COG0583	DNA-binding transcription factor activity
EfmKUHS13_RS12535	COG3711	transcriptional antiterminator
EfmKUHS13_RS12540	COG2190	(PTS) system
EfmKUHS13_RS12540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS12540	COG1263	PTS System
EfmKUHS13_RS12545	COG0702	epimerase
EfmKUHS13_RS12560	COG3708	Transcriptional regulator
EfmKUHS13_RS12560	COG2207	Transcriptional regulator
EfmKUHS13_RS12575	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EfmKUHS13_RS12585	COG0604	alcohol dehydrogenase
EfmKUHS13_RS12590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EfmKUHS13_RS12595	COG0842	Transport permease protein
EfmKUHS13_RS12600	COG1131	(ABC) transporter
EfmKUHS13_RS12610	COG2205	protein histidine kinase activity
EfmKUHS13_RS12615	COG0745	RESPONSE REGULATOR receiver
EfmKUHS13_RS12655	COG2188	Transcriptional regulator
EfmKUHS13_RS12660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EfmKUHS13_RS12665	COG3716	PTS system mannose fructose sorbose family IID component
EfmKUHS13_RS12670	COG3715	PTS system
EfmKUHS13_RS12680	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
EfmKUHS13_RS12685	COG2222	sugar isomerase
EfmKUHS13_RS12795	COG1674	ftsk spoiiie
EfmKUHS13_RS12805	COG1674	ftsk spoiiie
EfmKUHS13_RS12820	COG2946	Replication initiation factor
EfmKUHS13_RS12880	COG0741	lytic transglycosylase activity
EfmKUHS13_RS12880	COG0791	NLP P60 protein
EfmKUHS13_RS12925	COG3942	CHAP domain
EfmKUHS13_RS12925	COG1705	Flagellar rod assembly protein muramidase FlgJ
EfmKUHS13_RS12945	COG3708	Transcriptional regulator
EfmKUHS13_RS12945	COG2207	Transcriptional regulator
EfmKUHS13_RS12980	COG0523	cobalamin synthesis protein
EfmKUHS13_RS13000	COG0803	Belongs to the bacterial solute-binding protein 9 family
EfmKUHS13_RS13000	COG3443	Belongs to the bacterial solute-binding protein 9 family
EfmKUHS13_RS13015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EfmKUHS13_RS13025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EfmKUHS13_RS13030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EfmKUHS13_RS13035	COG1132	(ABC) transporter
EfmKUHS13_RS13040	COG1132	(ABC) transporter
EfmKUHS13_RS13050	COG1129	ABC transporter
EfmKUHS13_RS13060	COG1309	transcriptional regulator
EfmKUHS13_RS13095	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EfmKUHS13_RS13100	COG1082	Xylose isomerase domain protein TIM barrel
EfmKUHS13_RS13105	COG0673	inositol 2-dehydrogenase activity
EfmKUHS13_RS13120	COG1012	belongs to the aldehyde dehydrogenase family
EfmKUHS13_RS13130	COG3718	enzyme involved in inositol metabolism
EfmKUHS13_RS13135	COG3962	Belongs to the TPP enzyme family
EfmKUHS13_RS13140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EfmKUHS13_RS13150	COG1609	Transcriptional regulator
EfmKUHS13_RS13175	COG1378	Sugar-specific transcriptional regulator TrmB
EfmKUHS13_RS13200	COG4974	Belongs to the 'phage' integrase family
EfmKUHS13_RS13205	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EfmKUHS13_RS13210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EfmKUHS13_RS13215	COG0783	Belongs to the Dps family
EfmKUHS13_RS13220	COG1070	Carbohydrate kinase
EfmKUHS13_RS13225	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EfmKUHS13_RS13230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EfmKUHS13_RS13235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EfmKUHS13_RS13245	COG1554	hydrolase, family 65, central catalytic
EfmKUHS13_RS13250	COG0673	inositol 2-dehydrogenase activity
EfmKUHS13_RS13255	COG1082	Xylose isomerase domain protein TIM barrel
EfmKUHS13_RS13260	COG1063	alcohol dehydrogenase
EfmKUHS13_RS13265	COG0395	ABC-type sugar transport system, permease component
EfmKUHS13_RS13270	COG1175	transmembrane transport
EfmKUHS13_RS13275	COG1653	transport
EfmKUHS13_RS13280	COG0366	Alpha amylase catalytic
EfmKUHS13_RS13285	COG1609	Transcriptional regulator
EfmKUHS13_RS13290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EfmKUHS13_RS13295	COG0085	RNA polymerase activity
EfmKUHS13_RS13305	COG4120	Belongs to the binding-protein-dependent transport system permease family
EfmKUHS13_RS13315	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EfmKUHS13_RS13315	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EfmKUHS13_RS13330	COG0142	geranyltranstransferase activity
EfmKUHS13_RS13350	COG4939	FMN-binding domain protein
EfmKUHS13_RS13365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EfmKUHS13_RS13380	COG0542	response to heat
EfmKUHS13_RS13385	COG4463	regulation of RNA biosynthetic process
EfmKUHS13_RS13460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EfmKUHS13_RS13465	COG0517	IMP dehydrogenase activity
EfmKUHS13_RS13465	COG0516	GMP reductase activity
EfmKUHS13_RS13475	COG0012	GTP binding
EfmKUHS13_RS13480	COG4481	Protein conserved in bacteria
EfmKUHS13_RS13485	COG1475	DNA binding
EfmKUHS13_RS13490	COG1192	Involved in chromosome partitioning
EfmKUHS13_RS13495	COG0357	Ribosomal RNA small subunit methyltransferase G
EfmKUHS13_RS13500	COG0445	tRNA wobble uridine modification
EfmKUHS13_RS13505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EfmKUHS13_RS13515	COG1847	R3H domain protein
EfmKUHS13_RS13520	COG0706	membrane insertase activity
EfmKUHS13_RS13525	COG0594	ribonuclease P activity
EfmKUHS13_RS13530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EfmKUHS13_RS13755	COG0629	single-stranded DNA binding
EfmKUHS13_RS13760	COG0629	single-stranded DNA binding
EfmKUHS13_RS13810	COG3328	transposase activity
EfmKUHS13_RS13825	COG3775	system Galactitol-specific IIC component
EfmKUHS13_RS13840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EfmKUHS13_RS13850	COG4372	Transposase
EfmKUHS13_RS13885	COG1940	carbohydrate kinase activity
EfmKUHS13_RS13890	COG1263	PTS System
EfmKUHS13_RS13890	COG2190	(PTS) system
EfmKUHS13_RS13890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS13895	COG1621	beta-fructofuranosidase activity
EfmKUHS13_RS13900	COG1609	Transcriptional regulator
EfmKUHS13_RS13945	COG2190	(PTS) system
EfmKUHS13_RS13945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EfmKUHS13_RS13945	COG1263	PTS System
EfmKUHS13_RS13970	COG4974	Belongs to the 'phage' integrase family
EfmKUHS13_RS13980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EfmKUHS13_RS13990	COG3684	Belongs to the aldolase LacD family
EfmKUHS13_RS13995	COG2222	sugar isomerase
EfmKUHS13_RS14000	COG2188	Transcriptional regulator
EfmKUHS13_RS14010	COG3328	transposase activity
EfmKUHS13_RS14020	COG3328	transposase activity
EfmKUHS13_RS14035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EfmKUHS13_RS14045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EfmKUHS13_RS14055	COG3328	transposase activity
EfmKUHS13_RS14075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EfmKUHS13_RS14090	COG3842	ATPase activity
EfmKUHS13_RS14100	COG0395	ABC-type sugar transport system, permease component
EfmKUHS13_RS14115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EfmKUHS13_RS14135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EfmKUHS13_RS14155	COG1136	(ABC) transporter
EfmKUHS13_RS14175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EfmKUHS13_RS14210	COG0582	viral genome integration into host DNA
EfmKUHS13_RS14295	COG3684	Belongs to the aldolase LacD family
EfmKUHS13_RS14300	COG1105	Belongs to the carbohydrate kinase PfkB family
EfmKUHS13_RS14335	COG1192	Involved in chromosome partitioning
EfmKUHS13_RS14360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EfmKUHS13_RS14360	COG0551	DNA topoisomerase type I activity
EfmKUHS13_RS14370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EfmKUHS13_RS14380	COG2226	methyltransferase
EfmKUHS13_RS14415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EfmKUHS13_RS14430	COG3409	Peptidoglycan-binding domain 1 protein
EfmKUHS13_RS14450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EfmKUHS13_RS14515	COG1288	antiporter activity
EfmKUHS13_RS14535	COG2188	Transcriptional regulator
EfmKUHS13_RS14540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EfmKUHS13_RS14545	COG2222	sugar isomerase
EfmKUHS13_RS14595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EfmKUHS13_RS14600	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EfmKUHS13_RS14600	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EfmKUHS13_RS14605	COG2222	sugar isomerase
EfmKUHS13_RS14610	COG3716	PTS system mannose fructose sorbose family IID component
EfmKUHS13_RS14615	COG3715	PTS system
EfmKUHS13_RS14705	COG4152	abc transporter atp-binding protein
EfmKUHS13_RS14825	COG3328	transposase activity
EfmKUHS13_RS14835	COG0561	phosphatase activity
EfmKUHS13_RS14850	COG1278	Cold shock
EfmKUHS13_RS15035	COG1598	PFAM Uncharacterised protein family UPF0150
EfmKUHS13_RS15100	COG0542	response to heat
EfmKUHS13_RS15300	COG3764	Sortase (surface protein transpeptidase)
EfmKUHS13_RS15335	COG1674	ftsk spoiiie
EfmKUHS13_RS15465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EfmKUHS13_RS15510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity