locus-tag	class	description
FEF08_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FEF08_RS00010	COG0592	DNA-directed DNA polymerase activity
FEF08_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FEF08_RS00025	COG0187	DNA topoisomerase II activity
FEF08_RS00035	COG0360	Binds together with S18 to 16S ribosomal RNA
FEF08_RS00040	COG0629	single-stranded DNA binding
FEF08_RS00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FEF08_RS00055	COG0359	binds to the 23S rRNA
FEF08_RS00060	COG0305	Participates in initiation and elongation during chromosome replication
FEF08_RS00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FEF08_RS00085	COG0488	(ABC) transporter
FEF08_RS00095	COG0028	Belongs to the TPP enzyme family
FEF08_RS00170	COG2723	6-phospho-beta-galactosidase activity
FEF08_RS00180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS00180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS00190	COG0519	Catalyzes the synthesis of GMP from XMP
FEF08_RS00190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FEF08_RS00195	COG1072	(Pantothenic acid kinase))
FEF08_RS00200	COG2813	Specifically methylates the guanine in position
FEF08_RS00205	COG1609	Transcriptional regulator
FEF08_RS00210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FEF08_RS00215	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FEF08_RS00220	COG0295	cytidine deaminase activity
FEF08_RS00225	COG1744	ABC transporter substrate-binding protein PnrA-like
FEF08_RS00230	COG3845	ABC transporter
FEF08_RS00235	COG4603	Belongs to the binding-protein-dependent transport system permease family
FEF08_RS00240	COG1079	Belongs to the binding-protein-dependent transport system permease family
FEF08_RS00245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FEF08_RS00255	COG0813	purine-nucleoside phosphorylase activity
FEF08_RS00265	COG0588	phosphoglycerate mutase activity
FEF08_RS00275	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FEF08_RS00280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FEF08_RS00285	COG0049	tRNA binding
FEF08_RS00290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FEF08_RS00295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FEF08_RS00300	COG0051	transcription antitermination factor activity, RNA binding
FEF08_RS00305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FEF08_RS00310	COG0088	Forms part of the polypeptide exit tunnel
FEF08_RS00315	COG0089	rRNA binding
FEF08_RS00320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FEF08_RS00330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FEF08_RS00335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FEF08_RS00340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FEF08_RS00345	COG0255	Belongs to the universal ribosomal protein uL29 family
FEF08_RS00350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FEF08_RS00355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FEF08_RS00360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FEF08_RS00365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FEF08_RS00370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FEF08_RS00375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FEF08_RS00380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FEF08_RS00385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FEF08_RS00390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FEF08_RS00395	COG1841	ribosomal large subunit assembly
FEF08_RS00400	COG0200	Binds to the 23S rRNA
FEF08_RS00405	COG0201	protein transport
FEF08_RS00410	COG0563	adenylate kinase activity
FEF08_RS00415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FEF08_RS00420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FEF08_RS00425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FEF08_RS00430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FEF08_RS00435	COG0202	RNA polymerase activity
FEF08_RS00440	COG0203	ribosomal protein L17
FEF08_RS00445	COG1122	ATPase activity
FEF08_RS00450	COG1122	ATPase activity
FEF08_RS00460	COG0101	tRNA pseudouridine synthase activity
FEF08_RS00470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FEF08_RS00485	COG1461	Dihydroxyacetone kinase
FEF08_RS00490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FEF08_RS00495	COG0416	fatty acid biosynthetic process
FEF08_RS00500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FEF08_RS00510	COG4608	Belongs to the ABC transporter superfamily
FEF08_RS00515	COG0601	transmembrane transport
FEF08_RS00530	COG0571	ribonuclease III activity
FEF08_RS00535	COG1196	nuclear chromosome segregation
FEF08_RS00540	COG0561	phosphatase activity
FEF08_RS00545	COG0552	protein localization to endoplasmic reticulum
FEF08_RS00550	COG1181	Belongs to the D-alanine--D-alanine ligase family
FEF08_RS00550	COG2918	glutathione biosynthetic process
FEF08_RS00560	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FEF08_RS00565	COG4605	iron ion homeostasis
FEF08_RS00570	COG4604	ABC transporter, ATP-binding protein
FEF08_RS00575	COG4607	ABC-type enterochelin transport system periplasmic component
FEF08_RS00600	COG4886	Leucine-rich repeat (LRR) protein
FEF08_RS00600	COG4932	domain protein
FEF08_RS00615	COG3328	transposase activity
FEF08_RS00635	COG1380	Effector of murein hydrolase LrgA
FEF08_RS00655	COG1028	Short-chain dehydrogenase reductase Sdr
FEF08_RS00665	COG1268	BioY protein
FEF08_RS00685	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FEF08_RS00700	COG0561	phosphatase activity
FEF08_RS00720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FEF08_RS00730	COG0424	maF-like protein
FEF08_RS00735	COG1263	PTS System
FEF08_RS00735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS00740	COG2188	Transcriptional regulator
FEF08_RS00750	COG0632	four-way junction helicase activity
FEF08_RS00755	COG2255	four-way junction helicase activity
FEF08_RS00765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FEF08_RS00775	COG1114	Component of the transport system for branched-chain amino acids
FEF08_RS00785	COG1113	amino acid transport
FEF08_RS00790	COG1126	abc transporter atp-binding protein
FEF08_RS00795	COG0765	amino acid transport
FEF08_RS00810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FEF08_RS00815	COG0110	maltose O-acetyltransferase activity
FEF08_RS00820	COG1827	regulation of RNA biosynthetic process
FEF08_RS00830	COG0242	peptide deformylase activity
FEF08_RS00835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FEF08_RS00840	COG1185	polyribonucleotide nucleotidyltransferase activity
FEF08_RS00855	COG3158	transport of potassium into the cell
FEF08_RS00860	COG1253	flavin adenine dinucleotide binding
FEF08_RS00865	COG0534	Mate efflux family protein
FEF08_RS00875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FEF08_RS00880	COG1187	pseudouridine synthase activity
FEF08_RS00885	COG1011	Hydrolase
FEF08_RS00890	COG0572	uridine kinase
FEF08_RS00920	COG1671	Belongs to the UPF0178 family
FEF08_RS00930	COG1181	Belongs to the D-alanine--D-alanine ligase family
FEF08_RS00935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FEF08_RS00945	COG0736	holo-[acyl-carrier-protein] synthase activity
FEF08_RS00950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FEF08_RS00955	COG2337	Toxic component of a toxin-antitoxin (TA) module
FEF08_RS00965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FEF08_RS00970	COG3321	synthase
FEF08_RS00970	COG0604	alcohol dehydrogenase
FEF08_RS00985	COG0531	amino acid
FEF08_RS01015	COG1174	glycine betaine transport
FEF08_RS01050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FEF08_RS01070	COG1862	Preprotein translocase
FEF08_RS01080	COG1454	alcohol dehydrogenase
FEF08_RS01080	COG1012	belongs to the aldehyde dehydrogenase family
FEF08_RS01085	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FEF08_RS01115	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FEF08_RS01120	COG1028	Short-chain dehydrogenase reductase Sdr
FEF08_RS01125	COG1304	FMN binding
FEF08_RS01140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FEF08_RS01145	COG1428	Deoxynucleoside kinase
FEF08_RS01160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FEF08_RS01165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FEF08_RS01170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FEF08_RS01215	COG0824	Thioesterase
FEF08_RS01220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FEF08_RS01260	COG1363	Peptidase, m42
FEF08_RS01265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FEF08_RS01270	COG0589	response to stress
FEF08_RS01280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEF08_RS01285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FEF08_RS01290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FEF08_RS01295	COG2826	transposase and inactivated derivatives, IS30 family
FEF08_RS01325	COG2946	Replication initiation factor
FEF08_RS01370	COG0791	NLP P60 protein
FEF08_RS01370	COG0741	lytic transglycosylase activity
FEF08_RS01445	COG3328	transposase activity
FEF08_RS01455	COG3328	transposase activity
FEF08_RS01490	COG0531	amino acid
FEF08_RS01495	COG0076	glutamate decarboxylase activity
FEF08_RS01530	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEF08_RS01540	COG3715	PTS system
FEF08_RS01585	COG3328	transposase activity
FEF08_RS01625	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FEF08_RS01655	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FEF08_RS01655	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FEF08_RS01665	COG3715	PTS system
FEF08_RS01670	COG3716	PTS system mannose fructose sorbose family IID component
FEF08_RS01685	COG1940	carbohydrate kinase activity
FEF08_RS01690	COG4807	Protein conserved in bacteria
FEF08_RS01700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FEF08_RS01715	COG1764	response to oxidative stress
FEF08_RS01770	COG1368	sulfuric ester hydrolase activity
FEF08_RS01780	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FEF08_RS01790	COG0101	tRNA pseudouridine synthase activity
FEF08_RS01835	COG0667	Aldo Keto reductase
FEF08_RS01840	COG2186	Transcriptional regulator
FEF08_RS01845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS01850	COG2723	6-phospho-beta-galactosidase activity
FEF08_RS01860	COG1447	Phosphotransferase system cellobiose-specific component IIA
FEF08_RS01865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS01880	COG1063	alcohol dehydrogenase
FEF08_RS01890	COG4716	Myosin-crossreactive antigen
FEF08_RS01930	COG1113	amino acid transport
FEF08_RS01960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FEF08_RS01970	COG3052	prosthetic group binding
FEF08_RS02040	COG1051	belongs to the nudix hydrolase family
FEF08_RS02045	COG1846	Transcriptional regulator
FEF08_RS02075	COG0366	Alpha amylase catalytic
FEF08_RS02080	COG2723	6-phospho-beta-galactosidase activity
FEF08_RS02090	COG2190	(PTS) system
FEF08_RS02090	COG1263	PTS System
FEF08_RS02090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS02110	COG1902	pentaerythritol trinitrate reductase activity
FEF08_RS02120	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEF08_RS02130	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FEF08_RS02135	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FEF08_RS02140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FEF08_RS02145	COG1193	negative regulation of DNA recombination
FEF08_RS02150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FEF08_RS02170	COG1937	Protein conserved in bacteria
FEF08_RS02175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FEF08_RS02180	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEF08_RS02185	COG3973	AAA domain
FEF08_RS02195	COG1215	transferase activity, transferring glycosyl groups
FEF08_RS02210	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FEF08_RS02215	COG2376	Dihydroxyacetone kinase
FEF08_RS02220	COG1461	Dihydroxyacetone kinase
FEF08_RS02235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FEF08_RS02245	COG1131	(ABC) transporter
FEF08_RS02270	COG0531	amino acid
FEF08_RS02275	COG1757	Na H antiporter
FEF08_RS02280	COG1609	Transcriptional regulator
FEF08_RS02290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEF08_RS02300	COG1263	PTS System
FEF08_RS02300	COG2190	(PTS) system
FEF08_RS02300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS02330	COG3479	Phenolic acid decarboxylase
FEF08_RS02335	COG1695	Transcriptional regulator
FEF08_RS02345	COG2814	Major facilitator Superfamily
FEF08_RS02375	COG0163	prenyltransferase activity
FEF08_RS02380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FEF08_RS02390	COG0577	efflux transmembrane transporter activity
FEF08_RS02390	COG1136	(ABC) transporter
FEF08_RS02410	COG1811	Na channel or pump
FEF08_RS02445	COG1136	(ABC) transporter
FEF08_RS02460	COG3942	CHAP domain
FEF08_RS02460	COG1705	Flagellar rod assembly protein muramidase FlgJ
FEF08_RS02470	COG2190	(PTS) system
FEF08_RS02470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS02470	COG1263	PTS System
FEF08_RS02475	COG1869	D-ribose catabolic process
FEF08_RS02485	COG1609	Transcriptional regulator
FEF08_RS02505	COG0366	Alpha amylase catalytic
FEF08_RS02515	COG0628	permease
FEF08_RS02520	COG3443	Belongs to the bacterial solute-binding protein 9 family
FEF08_RS02520	COG0803	Belongs to the bacterial solute-binding protein 9 family
FEF08_RS02545	COG1428	Deoxynucleoside kinase
FEF08_RS02560	COG0210	DNA helicase
FEF08_RS02565	COG1393	Belongs to the ArsC family
FEF08_RS02570	COG1393	Belongs to the ArsC family
FEF08_RS02595	COG0386	Belongs to the glutathione peroxidase family
FEF08_RS02605	COG1854	S-ribosylhomocysteine lyase activity
FEF08_RS02610	COG0626	cystathionine gamma-synthase activity
FEF08_RS02620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FEF08_RS02635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FEF08_RS02640	COG3328	transposase activity
FEF08_RS02645	COG0019	diaminopimelate decarboxylase activity
FEF08_RS02650	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FEF08_RS02660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FEF08_RS02665	COG2171	N-acyltransferase activity
FEF08_RS02670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FEF08_RS02675	COG0527	aspartate kinase activity
FEF08_RS02685	COG0436	Aminotransferase
FEF08_RS02690	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEF08_RS02710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FEF08_RS02715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FEF08_RS02730	COG2207	Transcriptional regulator
FEF08_RS02735	COG2249	NAD(P)H dehydrogenase (quinone) activity
FEF08_RS02745	COG1113	amino acid transport
FEF08_RS02750	COG1121	(ABC) transporter
FEF08_RS02755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FEF08_RS02770	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FEF08_RS02775	COG2823	Periplasmic or secreted lipoprotein
FEF08_RS02775	COG1652	LysM domain
FEF08_RS02785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FEF08_RS02790	COG0477	Major facilitator Superfamily
FEF08_RS02800	COG1438	arginine binding
FEF08_RS02815	COG1764	response to oxidative stress
FEF08_RS02820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FEF08_RS02825	COG1335	isochorismatase
FEF08_RS02850	COG2135	peptidase activity
FEF08_RS02875	COG0745	RESPONSE REGULATOR receiver
FEF08_RS02880	COG2205	protein histidine kinase activity
FEF08_RS02885	COG4975	Glucose uptake
FEF08_RS02890	COG0531	amino acid
FEF08_RS02895	COG3853	Toxic anion resistance protein (TelA)
FEF08_RS02915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FEF08_RS02920	COG1335	isochorismatase
FEF08_RS02935	COG3590	peptidase
FEF08_RS02945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FEF08_RS02950	COG1104	cysteine desulfurase activity
FEF08_RS02970	COG0482	sulfurtransferase activity
FEF08_RS02980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FEF08_RS02985	COG2814	Major facilitator Superfamily
FEF08_RS03005	COG0463	Glycosyl transferase, family 2
FEF08_RS03010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FEF08_RS03015	COG2855	membrane
FEF08_RS03030	COG0583	DNA-binding transcription factor activity
FEF08_RS03040	COG0772	Belongs to the SEDS family
FEF08_RS03045	COG1393	Belongs to the ArsC family
FEF08_RS03050	COG0509	glycine decarboxylation via glycine cleavage system
FEF08_RS03055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FEF08_RS03060	COG2011	ABC-type metal ion transport system permease component
FEF08_RS03065	COG1464	Belongs to the NlpA lipoprotein family
FEF08_RS03075	COG0719	Fe-S assembly protein
FEF08_RS03080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FEF08_RS03090	COG0719	Fe-S assembly protein
FEF08_RS03120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS03120	COG1263	PTS System
FEF08_RS03135	COG2723	6-phospho-beta-galactosidase activity
FEF08_RS03140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS03140	COG1263	PTS System
FEF08_RS03140	COG2190	(PTS) system
FEF08_RS03145	COG3711	transcriptional antiterminator
FEF08_RS03200	COG0741	lytic transglycosylase activity
FEF08_RS03200	COG0791	NLP P60 protein
FEF08_RS03210	COG0433	COG0433 Predicted ATPase
FEF08_RS03240	COG2946	Replication initiation factor
FEF08_RS03245	COG1674	ftsk spoiiie
FEF08_RS03270	COG0464	growth
FEF08_RS03290	COG1136	(ABC) transporter
FEF08_RS03290	COG0577	efflux transmembrane transporter activity
FEF08_RS03295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FEF08_RS03305	COG1597	lipid kinase activity
FEF08_RS03350	COG3764	Sortase (surface protein transpeptidase)
FEF08_RS03355	COG3711	transcriptional antiterminator
FEF08_RS03360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS03360	COG1263	PTS System
FEF08_RS03360	COG2190	(PTS) system
FEF08_RS03365	COG2723	6-phospho-beta-galactosidase activity
FEF08_RS03370	COG2188	Transcriptional regulator
FEF08_RS03395	COG1611	Belongs to the LOG family
FEF08_RS03405	COG1428	Deoxynucleoside kinase
FEF08_RS03415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS03420	COG1472	Belongs to the glycosyl hydrolase 3 family
FEF08_RS03430	COG2723	6-phospho-beta-galactosidase activity
FEF08_RS03440	COG1368	sulfuric ester hydrolase activity
FEF08_RS03450	COG0105	UTP biosynthetic process
FEF08_RS03455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FEF08_RS03460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEF08_RS03470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FEF08_RS03475	COG2011	ABC-type metal ion transport system permease component
FEF08_RS03480	COG1464	Belongs to the NlpA lipoprotein family
FEF08_RS03490	COG1757	Na H antiporter
FEF08_RS03500	COG1113	amino acid transport
FEF08_RS03510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FEF08_RS03515	COG1929	Belongs to the glycerate kinase type-1 family
FEF08_RS03520	COG0488	(ABC) transporter
FEF08_RS03535	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FEF08_RS03540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS03540	COG1263	PTS System
FEF08_RS03545	COG1780	Probably involved in ribonucleotide reductase function
FEF08_RS03555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
FEF08_RS03560	COG1131	(ABC) transporter
FEF08_RS03580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FEF08_RS03595	COG0346	lactoylglutathione lyase activity
FEF08_RS03620	COG0561	phosphatase activity
FEF08_RS03625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FEF08_RS03630	COG0280	phosphate acetyltransferase
FEF08_RS03635	COG0802	atpase or kinase
FEF08_RS03640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FEF08_RS03660	COG0708	Exodeoxyribonuclease III
FEF08_RS03670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FEF08_RS03700	COG1053	succinate dehydrogenase
FEF08_RS03710	COG3321	synthase
FEF08_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
FEF08_RS03710	COG0604	alcohol dehydrogenase
FEF08_RS03715	COG0702	epimerase
FEF08_RS03720	COG4684	Psort location CytoplasmicMembrane, score
FEF08_RS03725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FEF08_RS03730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FEF08_RS03735	COG0604	alcohol dehydrogenase
FEF08_RS03745	COG3842	ATPase activity
FEF08_RS03750	COG1176	ABC-type spermidine putrescine transport system, permease component I
FEF08_RS03755	COG1177	transmembrane transport
FEF08_RS03760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FEF08_RS03765	COG3829	transcription factor binding
FEF08_RS03780	COG3715	PTS system
FEF08_RS03785	COG3716	PTS system mannose fructose sorbose family IID component
FEF08_RS03800	COG1940	carbohydrate kinase activity
FEF08_RS03840	COG0582	viral genome integration into host DNA
FEF08_RS03850	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FEF08_RS03860	COG0789	Transcriptional regulator
FEF08_RS03880	COG0504	CTP synthase activity
FEF08_RS03895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FEF08_RS03900	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FEF08_RS03905	COG0254	rRNA binding
FEF08_RS03930	COG1349	DNA-binding transcription factor activity
FEF08_RS03940	COG2814	Major facilitator Superfamily
FEF08_RS03950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FEF08_RS03970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FEF08_RS03975	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FEF08_RS03980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FEF08_RS03985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FEF08_RS03990	COG3870	Protein conserved in bacteria
FEF08_RS03995	COG0470	DNA polymerase III
FEF08_RS04000	COG1774	PSP1 C-terminal conserved region
FEF08_RS04005	COG4467	Involved in initiation control of chromosome replication
FEF08_RS04020	COG0602	queuosine metabolic process
FEF08_RS04025	COG1328	CTP reductase activity
FEF08_RS04030	COG1136	(ABC) transporter
FEF08_RS04035	COG0577	efflux transmembrane transporter activity
FEF08_RS04050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FEF08_RS04055	COG1696	Membrane protein involved in D-alanine export
FEF08_RS04060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FEF08_RS04065	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FEF08_RS04070	COG1363	Peptidase, m42
FEF08_RS04080	COG1234	tRNA 3'-trailer cleavage
FEF08_RS04085	COG0095	Lipoate-protein ligase
FEF08_RS04110	COG3759	membrane
FEF08_RS04115	COG0659	secondary active sulfate transmembrane transporter activity
FEF08_RS04125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FEF08_RS04135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FEF08_RS04140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FEF08_RS04140	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FEF08_RS04145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEF08_RS04145	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS04155	COG3715	PTS system
FEF08_RS04160	COG3716	PTS system mannose fructose sorbose family IID component
FEF08_RS04170	COG2261	transglycosylase associated protein
FEF08_RS04180	COG1302	Protein conserved in bacteria
FEF08_RS04185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FEF08_RS04190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FEF08_RS04195	COG1570	exodeoxyribonuclease VII activity
FEF08_RS04200	COG1722	exodeoxyribonuclease VII activity
FEF08_RS04210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FEF08_RS04215	COG1438	arginine binding
FEF08_RS04220	COG0497	DNA recombination
FEF08_RS04255	COG0768	penicillin binding
FEF08_RS04290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FEF08_RS04295	COG1799	cell septum assembly
FEF08_RS04305	COG2302	S4 RNA-binding domain
FEF08_RS04310	COG3599	regulation of cell shape
FEF08_RS04315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FEF08_RS04320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FEF08_RS04340	COG0673	inositol 2-dehydrogenase activity
FEF08_RS04345	COG0513	Belongs to the DEAD box helicase family
FEF08_RS04350	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FEF08_RS04350	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FEF08_RS04355	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS04360	COG1447	Phosphotransferase system cellobiose-specific component IIA
FEF08_RS04365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS04420	COG1396	sequence-specific DNA binding
FEF08_RS04565	COG0740	serine-type endopeptidase activity
FEF08_RS04710	COG2309	aminopeptidase activity
FEF08_RS04720	COG0716	FMN binding
FEF08_RS04725	COG0024	Methionine aminopeptidase
FEF08_RS04730	COG1295	ribonuclease BN
FEF08_RS04735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FEF08_RS04750	COG1215	transferase activity, transferring glycosyl groups
FEF08_RS04755	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FEF08_RS04765	COG1088	dTDP-glucose 4,6-dehydratase activity
FEF08_RS04770	COG1091	dTDP-4-dehydrorhamnose reductase activity
FEF08_RS04785	COG1682	transport, permease protein
FEF08_RS04795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FEF08_RS04800	COG0438	transferase activity, transferring glycosyl groups
FEF08_RS04800	COG1216	Glycosyl transferase, family 2
FEF08_RS04815	COG0463	Glycosyl transferase, family 2
FEF08_RS04820	COG0438	transferase activity, transferring glycosyl groups
FEF08_RS04845	COG1086	Polysaccharide biosynthesis protein
FEF08_RS04850	COG2089	acid synthase
FEF08_RS04855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FEF08_RS04865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FEF08_RS04880	COG1083	cytidylyl-transferase
FEF08_RS04915	COG3328	transposase activity
FEF08_RS04930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FEF08_RS04935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FEF08_RS04945	COG4585	Histidine kinase
FEF08_RS04955	COG0569	domain protein
FEF08_RS04980	COG2246	polysaccharide biosynthetic process
FEF08_RS04985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FEF08_RS04995	COG1316	TRANSCRIPTIONal
FEF08_RS05015	COG3397	chitin binding
FEF08_RS05020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FEF08_RS05025	COG2137	regulation of response to DNA damage stimulus
FEF08_RS05030	COG1194	a g-specific adenine glycosylase
FEF08_RS05035	COG3557	Belongs to the UPF0374 family
FEF08_RS05050	COG0628	permease
FEF08_RS05055	COG1253	flavin adenine dinucleotide binding
FEF08_RS05085	COG0542	response to heat
FEF08_RS05090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEF08_RS05105	COG0438	transferase activity, transferring glycosyl groups
FEF08_RS05110	COG2084	Dehydrogenase
FEF08_RS05115	COG4703	Protein of unknown function (DUF1797)
FEF08_RS05120	COG0322	excinuclease ABC activity
FEF08_RS05125	COG1846	Transcriptional regulator
FEF08_RS05130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FEF08_RS05140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FEF08_RS05150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FEF08_RS05160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FEF08_RS05165	COG0439	Biotin carboxylase
FEF08_RS05170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FEF08_RS05175	COG0825	malonyl-CoA metabolic process
FEF08_RS05180	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FEF08_RS05185	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FEF08_RS05190	COG1534	Rna-binding protein
FEF08_RS05195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FEF08_RS05200	COG1713	HD superfamily hydrolase involved in NAD metabolism
FEF08_RS05205	COG0799	negative regulation of ribosome biogenesis
FEF08_RS05210	COG2226	methyltransferase
FEF08_RS05215	COG1323	Belongs to the UPF0348 family
FEF08_RS05220	COG0217	transcriptional regulatory protein
FEF08_RS05230	COG3973	AAA domain
FEF08_RS05235	COG2217	Heavy metal translocating P-type atpase
FEF08_RS05240	COG1942	4-Oxalocrotonate Tautomerase
FEF08_RS05250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FEF08_RS05255	COG1737	Transcriptional regulator
FEF08_RS05260	COG0768	penicillin binding
FEF08_RS05270	COG0561	phosphatase activity
FEF08_RS05275	COG2252	PERMEase
FEF08_RS05280	COG2814	Major facilitator Superfamily
FEF08_RS05290	COG0587	DNA-directed DNA polymerase activity
FEF08_RS05295	COG0205	6-phosphofructokinase activity
FEF08_RS05305	COG0583	DNA-binding transcription factor activity
FEF08_RS05315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FEF08_RS05320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FEF08_RS05325	COG0745	RESPONSE REGULATOR receiver
FEF08_RS05330	COG5002	protein histidine kinase activity
FEF08_RS05440	COG3711	transcriptional antiterminator
FEF08_RS05450	COG2190	(PTS) system
FEF08_RS05450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS05450	COG1263	PTS System
FEF08_RS05455	COG1486	melibiose metabolic process
FEF08_RS05460	COG2190	(PTS) system
FEF08_RS05460	COG1263	PTS System
FEF08_RS05460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS05465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS05490	COG1349	DNA-binding transcription factor activity
FEF08_RS05515	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FEF08_RS05520	COG3623	hexulose-6-phosphate isomerase
FEF08_RS05530	COG0456	acetyltransferase
FEF08_RS05555	COG3711	transcriptional antiterminator
FEF08_RS05575	COG3775	system Galactitol-specific IIC component
FEF08_RS05590	COG0400	carboxylic ester hydrolase activity
FEF08_RS05595	COG0346	lactoylglutathione lyase activity
FEF08_RS05605	COG2188	Transcriptional regulator
FEF08_RS05610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS05615	COG2723	6-phospho-beta-galactosidase activity
FEF08_RS05620	COG0589	response to stress
FEF08_RS05635	COG1393	Belongs to the ArsC family
FEF08_RS05645	COG0351	phosphomethylpyrimidine kinase
FEF08_RS05650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FEF08_RS05655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FEF08_RS05665	COG3425	synthase
FEF08_RS05670	COG0183	Belongs to the thiolase family
FEF08_RS05690	COG0656	L-ascorbic acid biosynthetic process
FEF08_RS05710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FEF08_RS05710	COG0392	lysyltransferase activity
FEF08_RS05715	COG0596	Alpha beta hydrolase
FEF08_RS05720	COG0741	lytic transglycosylase activity
FEF08_RS05730	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FEF08_RS05735	COG0358	DNA primase activity
FEF08_RS05740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FEF08_RS05755	COG2996	Protein conserved in bacteria
FEF08_RS05760	COG0735	belongs to the Fur family
FEF08_RS05765	COG4974	Belongs to the 'phage' integrase family
FEF08_RS05775	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FEF08_RS05780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FEF08_RS05785	COG1187	pseudouridine synthase activity
FEF08_RS05790	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FEF08_RS05795	COG1288	antiporter activity
FEF08_RS05800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEF08_RS05820	COG0514	ATP-dependent DNA helicase (RecQ)
FEF08_RS05830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FEF08_RS05835	COG0539	negative regulation of cytoplasmic translation
FEF08_RS05840	COG1160	GTP binding
FEF08_RS05845	COG0776	regulation of translation
FEF08_RS05860	COG0457	Tetratricopeptide repeat
FEF08_RS05865	COG5582	Belongs to the UPF0302 family
FEF08_RS05870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FEF08_RS05875	COG1694	Mazg nucleotide pyrophosphohydrolase
FEF08_RS05880	COG0617	tRNA 3'-terminal CCA addition
FEF08_RS05900	COG0488	(ABC) transporter
FEF08_RS05905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FEF08_RS05915	COG1272	protein, Hemolysin III
FEF08_RS05920	COG1307	EDD domain protein, DegV family
FEF08_RS05925	COG2755	lipolytic protein G-D-S-L family
FEF08_RS05930	COG4698	Protein conserved in bacteria
FEF08_RS05940	COG4479	Belongs to the UPF0346 family
FEF08_RS05945	COG0681	Belongs to the peptidase S26 family
FEF08_RS05960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FEF08_RS05965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FEF08_RS05970	COG0758	DNA mediated transformation
FEF08_RS05975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FEF08_RS05980	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FEF08_RS05985	COG4974	Belongs to the 'phage' integrase family
FEF08_RS05990	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FEF08_RS06010	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FEF08_RS06015	COG1832	CoA-binding protein
FEF08_RS06020	COG0187	DNA topoisomerase II activity
FEF08_RS06030	COG1882	Formate acetyltransferase
FEF08_RS06035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FEF08_RS06040	COG1227	inorganic diphosphatase activity
FEF08_RS06060	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FEF08_RS06070	COG1073	alpha beta
FEF08_RS06075	COG1609	Transcriptional regulator
FEF08_RS06085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FEF08_RS06105	COG1732	Glycine betaine
FEF08_RS06120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FEF08_RS06130	COG1116	anion transmembrane transporter activity
FEF08_RS06135	COG0084	hydrolase, TatD family'
FEF08_RS06140	COG1388	LysM domain
FEF08_RS06140	COG3942	CHAP domain
FEF08_RS06155	COG0346	lactoylglutathione lyase activity
FEF08_RS06165	COG3328	transposase activity
FEF08_RS06180	COG0436	Aminotransferase
FEF08_RS06200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FEF08_RS06205	COG4565	transcriptional regulatory protein
FEF08_RS06210	COG3290	protein histidine kinase activity
FEF08_RS06215	COG3290	protein histidine kinase activity
FEF08_RS06230	COG2268	Band 7 protein
FEF08_RS06250	COG0673	inositol 2-dehydrogenase activity
FEF08_RS06260	COG1876	peptidase activity
FEF08_RS06265	COG1705	Flagellar rod assembly protein muramidase FlgJ
FEF08_RS06265	COG1388	LysM domain
FEF08_RS06275	COG1653	transport
FEF08_RS06280	COG1175	transmembrane transport
FEF08_RS06285	COG0395	ABC-type sugar transport system, permease component
FEF08_RS06300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FEF08_RS06305	COG2233	PERMEase
FEF08_RS06315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FEF08_RS06320	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FEF08_RS06325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FEF08_RS06335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FEF08_RS06340	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FEF08_RS06345	COG0047	phosphoribosylformylglycinamidine synthase activity
FEF08_RS06350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FEF08_RS06360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FEF08_RS06365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FEF08_RS06370	COG0138	bifunctional purine biosynthesis protein purh
FEF08_RS06375	COG0151	Belongs to the GarS family
FEF08_RS06380	COG4989	oxidoreductase activity
FEF08_RS06395	COG2972	Histidine kinase
FEF08_RS06405	COG4213	ABC transporter substrate-binding protein
FEF08_RS06415	COG4214	carbohydrate transport
FEF08_RS06420	COG0516	GMP reductase activity
FEF08_RS06430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEF08_RS06445	COG0022	dehydrogenase e1 component
FEF08_RS06460	COG4476	Belongs to the UPF0223 family
FEF08_RS06465	COG0483	inositol monophosphate 1-phosphatase activity
FEF08_RS06470	COG1217	gtp-binding protein TYPA
FEF08_RS06475	COG0514	ATP-dependent DNA helicase (RecQ)
FEF08_RS06480	COG4838	Belongs to the UPF0358 family
FEF08_RS06485	COG0772	Belongs to the SEDS family
FEF08_RS06490	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FEF08_RS06505	COG4471	UPF0298 protein
FEF08_RS06510	COG0742	ribosomal rna small subunit methyltransferase
FEF08_RS06515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FEF08_RS06520	COG3480	Lon protease (S16) C-terminal proteolytic domain
FEF08_RS06525	COG1596	polysaccharide export
FEF08_RS06525	COG1555	photosystem II stabilization
FEF08_RS06540	COG2131	deaminase
FEF08_RS06545	COG0658	competence protein
FEF08_RS06545	COG2333	competence protein COMEC
FEF08_RS06550	COG1466	dna polymerase III delta subunit
FEF08_RS06555	COG0268	Binds directly to 16S ribosomal RNA
FEF08_RS06565	COG2707	UPF0756 membrane protein
FEF08_RS06570	COG2217	Heavy metal translocating P-type atpase
FEF08_RS06575	COG1968	undecaprenyl-diphosphatase activity
FEF08_RS06595	COG1666	GTP binding
FEF08_RS06600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FEF08_RS06605	COG2151	metal-sulfur cluster biosynthetic enzyme
FEF08_RS06620	COG3942	CHAP domain
FEF08_RS06620	COG1388	LysM domain
FEF08_RS06675	COG4990	cell redox homeostasis
FEF08_RS06695	COG3104	oligopeptide transport
FEF08_RS06705	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FEF08_RS06710	COG1074	ATP-dependent DNA helicase activity
FEF08_RS06715	COG1733	regulation of RNA biosynthetic process
FEF08_RS06720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FEF08_RS06725	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEF08_RS06725	COG0072	phenylalanine-tRNA ligase activity
FEF08_RS06740	COG1126	abc transporter atp-binding protein
FEF08_RS06745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FEF08_RS06750	COG0765	amino acid transport
FEF08_RS06755	COG0765	amino acid transport
FEF08_RS06760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FEF08_RS06765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FEF08_RS06775	COG0517	IMP dehydrogenase activity
FEF08_RS06780	COG0668	transmembrane transport
FEF08_RS06785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FEF08_RS06790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FEF08_RS06795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FEF08_RS06825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FEF08_RS06835	COG1234	tRNA 3'-trailer cleavage
FEF08_RS06840	COG0300	oxidoreductase activity
FEF08_RS06845	COG5416	Lipopolysaccharide assembly protein A domain
FEF08_RS06850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FEF08_RS06850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FEF08_RS06855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FEF08_RS06890	COG1388	LysM domain
FEF08_RS06890	COG1705	Flagellar rod assembly protein muramidase FlgJ
FEF08_RS06895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FEF08_RS06900	COG0735	belongs to the Fur family
FEF08_RS06905	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEF08_RS06915	COG1846	Transcriptional regulator
FEF08_RS06925	COG3935	DnaD domain protein
FEF08_RS06930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FEF08_RS06940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FEF08_RS06945	COG3331	DNA recombination
FEF08_RS06950	COG4474	Belongs to the UPF0398 family
FEF08_RS06955	COG3599	regulation of cell shape
FEF08_RS06965	COG0116	Belongs to the methyltransferase superfamily
FEF08_RS06970	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FEF08_RS06975	COG1418	mRNA catabolic process
FEF08_RS06990	COG0156	8-amino-7-oxononanoate synthase activity
FEF08_RS06995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FEF08_RS07000	COG0531	amino acid
FEF08_RS07015	COG0513	Belongs to the DEAD box helicase family
FEF08_RS07020	COG2153	protein acetylation
FEF08_RS07030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FEF08_RS07035	COG4684	Psort location CytoplasmicMembrane, score
FEF08_RS07045	COG0328	RNA-DNA hybrid ribonuclease activity
FEF08_RS07055	COG1278	Cold shock
FEF08_RS07075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FEF08_RS07080	COG0564	pseudouridine synthase activity
FEF08_RS07090	COG2233	PERMEase
FEF08_RS07095	COG0540	Belongs to the ATCase OTCase family
FEF08_RS07100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FEF08_RS07105	COG0505	Belongs to the CarA family
FEF08_RS07115	COG0543	2 iron, 2 sulfur cluster binding
FEF08_RS07125	COG0284	orotidine-5'-phosphate decarboxylase activity
FEF08_RS07155	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FEF08_RS07175	COG4120	Belongs to the binding-protein-dependent transport system permease family
FEF08_RS07185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FEF08_RS07220	COG2826	transposase and inactivated derivatives, IS30 family
FEF08_RS07225	COG0039	L-malate dehydrogenase activity
FEF08_RS07245	COG3037	sugar-specific permease SgaT UlaA
FEF08_RS07255	COG3711	transcriptional antiterminator
FEF08_RS07265	COG0673	inositol 2-dehydrogenase activity
FEF08_RS07315	COG0745	RESPONSE REGULATOR receiver
FEF08_RS07320	COG5002	protein histidine kinase activity
FEF08_RS07325	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
FEF08_RS07335	COG0318	PFAM AMP-dependent synthetase and ligase
FEF08_RS07340	COG0351	phosphomethylpyrimidine kinase
FEF08_RS07350	COG4475	Protein of unknown function (DUF436)
FEF08_RS07355	COG0366	Alpha amylase catalytic
FEF08_RS07375	COG1307	EDD domain protein, DegV family
FEF08_RS07380	COG2244	polysaccharide biosynthetic process
FEF08_RS07435	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FEF08_RS07440	COG0194	GDP metabolic process
FEF08_RS07460	COG0765	amino acid transport
FEF08_RS07465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FEF08_RS07475	COG0167	dihydroorotate dehydrogenase activity
FEF08_RS07485	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FEF08_RS07495	COG3833	ABC-type maltose transport systems, permease component
FEF08_RS07500	COG1175	transmembrane transport
FEF08_RS07505	COG2182	Extracellular solute-binding protein
FEF08_RS07510	COG0366	Alpha amylase catalytic
FEF08_RS07515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FEF08_RS07525	COG1764	response to oxidative stress
FEF08_RS07530	COG1846	Transcriptional regulator
FEF08_RS07535	COG0628	permease
FEF08_RS07550	COG1312	Catalyzes the dehydration of D-mannonate
FEF08_RS07555	COG0246	Mannitol dehydrogenase
FEF08_RS07565	COG0450	alkyl hydroperoxide reductase
FEF08_RS07605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FEF08_RS07620	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FEF08_RS07635	COG0531	amino acid
FEF08_RS07640	COG0004	ammonium transporteR
FEF08_RS07650	COG2261	transglycosylase associated protein
FEF08_RS07690	COG3655	Transcriptional regulator
FEF08_RS07700	COG2261	transglycosylase associated protein
FEF08_RS07720	COG1028	Short-chain dehydrogenase reductase Sdr
FEF08_RS07735	COG1442	glycosyl transferase family 8
FEF08_RS07740	COG1442	glycosyl transferase family 8
FEF08_RS07745	COG0561	phosphatase activity
FEF08_RS07770	COG1476	TRANSCRIPTIONal
FEF08_RS07790	COG1278	Cold shock
FEF08_RS07795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEF08_RS07800	COG1312	Catalyzes the dehydration of D-mannonate
FEF08_RS07820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS07825	COG3716	PTS system mannose fructose sorbose family IID component
FEF08_RS07835	COG3732	PTS system glucitol sorbitol-specific
FEF08_RS07840	COG3730	PTS system glucitol sorbitol-specific
FEF08_RS07850	COG3711	transcriptional antiterminator
FEF08_RS07850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEF08_RS07900	COG4974	Belongs to the 'phage' integrase family
FEF08_RS07905	COG0481	GTPase activity
FEF08_RS07925	COG0542	response to heat
FEF08_RS07940	COG1597	lipid kinase activity
FEF08_RS07945	COG2195	Cleaves the N-terminal amino acid of tripeptides
FEF08_RS07950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FEF08_RS07955	COG2384	SAM-dependent methyltransferase
FEF08_RS07965	COG1484	DNA-dependent DNA replication
FEF08_RS07975	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FEF08_RS07985	COG0237	dephospho-CoA kinase activity
FEF08_RS07990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FEF08_RS07995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FEF08_RS07995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FEF08_RS08010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FEF08_RS08015	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FEF08_RS08020	COG3091	SprT-like family
FEF08_RS08025	COG2183	response to ionizing radiation
FEF08_RS08035	COG1054	Belongs to the UPF0176 family
FEF08_RS08065	COG0546	phosphoglycolate phosphatase activity
FEF08_RS08070	COG0588	phosphoglycerate mutase activity
FEF08_RS08125	COG4753	response regulator
FEF08_RS08125	COG2207	Transcriptional regulator
FEF08_RS08135	COG2972	Histidine kinase
FEF08_RS08140	COG0077	Prephenate dehydratase
FEF08_RS08145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FEF08_RS08150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FEF08_RS08155	COG0287	Prephenate dehydrogenase
FEF08_RS08160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FEF08_RS08170	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FEF08_RS08180	COG3250	beta-galactosidase activity
FEF08_RS08195	COG1609	Transcriptional regulator
FEF08_RS08210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FEF08_RS08220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FEF08_RS08230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FEF08_RS08235	COG0154	amidase activity
FEF08_RS08240	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FEF08_RS08245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FEF08_RS08250	COG0210	DNA helicase
FEF08_RS08260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEF08_RS08260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEF08_RS08260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FEF08_RS08265	COG1105	Belongs to the carbohydrate kinase PfkB family
FEF08_RS08270	COG1349	DNA-binding transcription factor activity
FEF08_RS08285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FEF08_RS08290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FEF08_RS08295	COG0544	peptidyl-prolyl cis-trans isomerase activity
FEF08_RS08305	COG1714	RDD family
FEF08_RS08320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FEF08_RS08325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FEF08_RS08400	COG1481	regulation of sporulation
FEF08_RS08405	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FEF08_RS08410	COG1660	Displays ATPase and GTPase activities
FEF08_RS08425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FEF08_RS08430	COG0556	nucleotide-excision repair
FEF08_RS08435	COG0765	amino acid transport
FEF08_RS08440	COG1126	abc transporter atp-binding protein
FEF08_RS08450	COG0484	heat shock protein binding
FEF08_RS08455	COG0443	Heat shock 70 kDa protein
FEF08_RS08460	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FEF08_RS08465	COG1420	regulation of RNA biosynthetic process
FEF08_RS08470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FEF08_RS08510	COG0693	protein deglycase activity
FEF08_RS08520	COG1619	proteins homologs of microcin C7 resistance protein MccF
FEF08_RS08530	COG5646	InterPro IPR014922
FEF08_RS08540	COG4975	Glucose uptake
FEF08_RS08555	COG0196	riboflavin kinase activity
FEF08_RS08560	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FEF08_RS08565	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FEF08_RS08570	COG1175	transmembrane transport
FEF08_RS08575	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FEF08_RS08590	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FEF08_RS08595	COG0195	Participates in both transcription termination and antitermination
FEF08_RS08600	COG0779	Required for maturation of 30S ribosomal subunits
FEF08_RS08605	COG2176	DNA-directed DNA polymerase activity
FEF08_RS08610	COG0442	prolyl-tRNA aminoacylation
FEF08_RS08615	COG0750	zinc metalloprotease
FEF08_RS08620	COG4589	Belongs to the CDS family
FEF08_RS08625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FEF08_RS08635	COG0233	cytoplasmic translational termination
FEF08_RS08640	COG0528	UMP kinase activity
FEF08_RS08645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FEF08_RS08650	COG0052	Belongs to the universal ribosomal protein uS2 family
FEF08_RS08655	COG1438	arginine binding
FEF08_RS08665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEF08_RS08675	COG0018	arginyl-trna synthetase
FEF08_RS08690	COG2235	arginine
FEF08_RS08695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FEF08_RS08700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FEF08_RS08705	COG0456	acetyltransferase
FEF08_RS08715	COG1214	PFAM Peptidase M22, glycoprotease
FEF08_RS08720	COG1609	Transcriptional regulator
FEF08_RS08725	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
FEF08_RS08730	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FEF08_RS08745	COG3189	MarR family transcriptional regulator
FEF08_RS08750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FEF08_RS08755	COG1940	carbohydrate kinase activity
FEF08_RS08770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FEF08_RS08775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FEF08_RS08780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FEF08_RS08785	COG1120	ATPase activity
FEF08_RS08800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FEF08_RS08805	COG4876	unkown
FEF08_RS08810	COG0367	asparagine synthase
FEF08_RS08840	COG1309	transcriptional regulator
FEF08_RS08860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FEF08_RS08875	COG0584	glycerophosphoryl diester phosphodiesterase
FEF08_RS08900	COG0166	Belongs to the GPI family
FEF08_RS08905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FEF08_RS08910	COG2081	HI0933 family
FEF08_RS08915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FEF08_RS08920	COG0710	3-dehydroquinate dehydratase activity
FEF08_RS08925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FEF08_RS08930	COG1368	sulfuric ester hydrolase activity
FEF08_RS08965	COG3850	Histidine kinase
FEF08_RS08965	COG5002	protein histidine kinase activity
FEF08_RS08970	COG0745	RESPONSE REGULATOR receiver
FEF08_RS09010	COG3328	transposase activity
FEF08_RS09025	COG1956	GAF domain-containing protein
FEF08_RS09030	COG3527	Alpha-acetolactate decarboxylase
FEF08_RS09035	COG0028	Belongs to the TPP enzyme family
FEF08_RS09045	COG0395	ABC-type sugar transport system, permease component
FEF08_RS09055	COG0583	DNA-binding transcription factor activity
FEF08_RS09060	COG0789	Transcriptional regulator
FEF08_RS09065	COG2814	Major facilitator Superfamily
FEF08_RS09135	COG4974	Belongs to the 'phage' integrase family
FEF08_RS09160	COG4372	Transposase
FEF08_RS09190	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS09190	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEF08_RS09195	COG3716	PTS system mannose fructose sorbose family IID component
FEF08_RS09200	COG3715	PTS system
FEF08_RS09205	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FEF08_RS09205	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FEF08_RS09210	COG1940	carbohydrate kinase activity
FEF08_RS09215	COG2190	(PTS) system
FEF08_RS09230	COG1609	Transcriptional regulator
FEF08_RS09255	COG3385	transposase activity
FEF08_RS09275	COG0741	lytic transglycosylase activity
FEF08_RS09275	COG0791	NLP P60 protein
FEF08_RS09305	COG1196	nuclear chromosome segregation
FEF08_RS09350	COG1674	ftsk spoiiie
FEF08_RS09385	COG0335	large ribosomal subunit rRNA binding
FEF08_RS09390	COG0336	Belongs to the RNA methyltransferase TrmD family
FEF08_RS09395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FEF08_RS09405	COG1837	Belongs to the UPF0109 family
FEF08_RS09410	COG0228	four-way junction DNA binding
FEF08_RS09415	COG0431	NADPH-dependent FMN reductase
FEF08_RS09420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FEF08_RS09425	COG0519	Catalyzes the synthesis of GMP from XMP
FEF08_RS09430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FEF08_RS09435	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FEF08_RS09445	COG0745	RESPONSE REGULATOR receiver
FEF08_RS09450	COG5002	protein histidine kinase activity
FEF08_RS09455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FEF08_RS09470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FEF08_RS09505	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FEF08_RS09575	COG0714	Associated with various cellular activities
FEF08_RS09595	COG2217	Heavy metal translocating P-type atpase
FEF08_RS09600	COG2217	Heavy metal translocating P-type atpase
FEF08_RS09605	COG2608	mercury ion transmembrane transporter activity
FEF08_RS09610	COG3682	Transcriptional regulator
FEF08_RS09620	COG0531	amino acid
FEF08_RS09625	COG2217	Heavy metal translocating P-type atpase
FEF08_RS09650	COG0017	Asparaginyl-tRNA synthetase
FEF08_RS09655	COG0436	Aminotransferase
FEF08_RS09665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FEF08_RS09665	COG1199	ATP-dependent helicase activity
FEF08_RS09670	COG1278	Cold shock
FEF08_RS09685	COG1686	Belongs to the peptidase S11 family
FEF08_RS09695	COG0038	chloride channel
FEF08_RS09715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FEF08_RS09720	COG1254	Belongs to the acylphosphatase family
FEF08_RS09735	COG0706	membrane insertase activity
FEF08_RS09825	COG2244	polysaccharide biosynthetic process
FEF08_RS09840	COG1216	Glycosyl transferase, family 2
FEF08_RS09840	COG1442	glycosyl transferase family 8
FEF08_RS09880	COG0438	transferase activity, transferring glycosyl groups
FEF08_RS09905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FEF08_RS09910	COG4464	protein tyrosine phosphatase activity
FEF08_RS09915	COG0489	protein tyrosine kinase activity
FEF08_RS09925	COG1316	TRANSCRIPTIONal
FEF08_RS09940	COG0751	glycine-tRNA ligase activity
FEF08_RS09945	COG0752	glycyl-tRNA synthetase alpha subunit
FEF08_RS09950	COG1381	Involved in DNA repair and RecF pathway recombination
FEF08_RS09955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FEF08_RS09960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FEF08_RS09965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FEF08_RS09975	COG1702	phosphate starvation-inducible protein PhoH
FEF08_RS09980	COG1114	Component of the transport system for branched-chain amino acids
FEF08_RS09985	COG1610	YqeY-like protein
FEF08_RS09990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FEF08_RS09995	COG0735	belongs to the Fur family
FEF08_RS10000	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FEF08_RS10005	COG0640	Transcriptional regulator
FEF08_RS10010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FEF08_RS10015	COG0492	ferredoxin-NADP+ reductase activity
FEF08_RS10020	COG2723	6-phospho-beta-galactosidase activity
FEF08_RS10025	COG1486	melibiose metabolic process
FEF08_RS10035	COG1737	Transcriptional regulator
FEF08_RS10040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS10040	COG1263	PTS System
FEF08_RS10040	COG2190	(PTS) system
FEF08_RS10045	COG3711	transcriptional antiterminator
FEF08_RS10055	COG1132	(ABC) transporter
FEF08_RS10060	COG1132	(ABC) transporter
FEF08_RS10065	COG3763	UPF0154 protein
FEF08_RS10075	COG1914	H( )-stimulated, divalent metal cation uptake system
FEF08_RS10090	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FEF08_RS10120	COG1609	Transcriptional regulator
FEF08_RS10130	COG4980	gas vesicle protein
FEF08_RS10140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FEF08_RS10145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FEF08_RS10150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FEF08_RS10155	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FEF08_RS10160	COG1950	PFAM Membrane protein of
FEF08_RS10195	COG0704	Plays a role in the regulation of phosphate uptake
FEF08_RS10200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FEF08_RS10205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FEF08_RS10210	COG0581	inorganic phosphate transmembrane transporter activity
FEF08_RS10215	COG0573	inorganic phosphate transmembrane transporter activity
FEF08_RS10220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FEF08_RS10225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FEF08_RS10235	COG2177	Part of the ABC transporter FtsEX involved in
FEF08_RS10240	COG2884	Cell division ATP-binding protein ftsE
FEF08_RS10250	COG0653	protein targeting
FEF08_RS10265	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FEF08_RS10270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS10280	COG1739	Uncharacterized protein family UPF0029
FEF08_RS10285	COG2188	Transcriptional regulator
FEF08_RS10305	COG1940	carbohydrate kinase activity
FEF08_RS10325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FEF08_RS10335	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FEF08_RS10340	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FEF08_RS10345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FEF08_RS10350	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FEF08_RS10355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FEF08_RS10360	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FEF08_RS10365	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FEF08_RS10370	COG0356	it plays a direct role in the translocation of protons across the membrane
FEF08_RS10375	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FEF08_RS10380	COG0557	exoribonuclease II activity
FEF08_RS10390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FEF08_RS10395	COG2388	GCN5-related N-acetyl-transferase
FEF08_RS10405	COG1957	nucleoside hydrolase
FEF08_RS10430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FEF08_RS10440	COG0149	triose-phosphate isomerase activity
FEF08_RS10445	COG0126	phosphoglycerate kinase activity
FEF08_RS10455	COG2390	Transcriptional regulator
FEF08_RS10460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FEF08_RS10480	COG1595	DNA-templated transcription, initiation
FEF08_RS10500	COG0095	Lipoate-protein ligase
FEF08_RS10505	COG1078	dGTPase activity
FEF08_RS10515	COG0494	nUDIX hydrolase
FEF08_RS10520	COG0346	lactoylglutathione lyase activity
FEF08_RS10530	COG2423	ornithine cyclodeaminase activity
FEF08_RS10535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEF08_RS10540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FEF08_RS10545	COG1394	ATPase activity, coupled to movement of substances
FEF08_RS10550	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
FEF08_RS10555	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
FEF08_RS10560	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
FEF08_RS10565	COG1527	subunit (C
FEF08_RS10570	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
FEF08_RS10575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FEF08_RS10580	COG1269	ATP hydrolysis coupled proton transport
FEF08_RS10590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FEF08_RS10595	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FEF08_RS10610	COG0322	excinuclease ABC activity
FEF08_RS10615	COG3118	belongs to the thioredoxin family
FEF08_RS10620	COG1193	negative regulation of DNA recombination
FEF08_RS10635	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FEF08_RS10650	COG1136	(ABC) transporter
FEF08_RS10660	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEF08_RS10695	COG1304	FMN binding
FEF08_RS10705	COG0281	malic enzyme
FEF08_RS10750	COG4695	Portal protein
FEF08_RS10830	COG4974	Belongs to the 'phage' integrase family
FEF08_RS10910	COG0582	viral genome integration into host DNA
FEF08_RS10915	COG3906	Belongs to the UPF0473 family
FEF08_RS10920	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FEF08_RS10925	COG4472	Bacterial protein of unknown function (DUF965)
FEF08_RS10955	COG4555	ABC transporter
FEF08_RS10975	COG3689	TIGRFAM TIGR03943 family protein
FEF08_RS10980	COG0701	Predicted permease
FEF08_RS10985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FEF08_RS10990	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FEF08_RS10995	COG0488	(ABC) transporter
FEF08_RS11000	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FEF08_RS11015	COG0395	ABC-type sugar transport system, permease component
FEF08_RS11040	COG0446	pyridine nucleotide-disulphide oxidoreductase
FEF08_RS11050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FEF08_RS11055	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FEF08_RS11060	COG0584	glycerophosphoryl diester phosphodiesterase
FEF08_RS11070	COG0740	serine-type endopeptidase activity
FEF08_RS11075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FEF08_RS11085	COG1132	(ABC) transporter
FEF08_RS11095	COG5503	Protein of unknown function (DUF1447)
FEF08_RS11110	COG1278	Cold shock
FEF08_RS11120	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FEF08_RS11140	COG0488	(ABC) transporter
FEF08_RS11175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEF08_RS11180	COG0285	dihydrofolate synthase activity
FEF08_RS11185	COG0525	valine-tRNA ligase activity
FEF08_RS11190	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FEF08_RS11195	COG0301	tRNA thio-modification
FEF08_RS11205	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FEF08_RS11215	COG0561	phosphatase activity
FEF08_RS11220	COG1801	Protein of unknown function DUF72
FEF08_RS11240	COG3579	cysteine-type endopeptidase activity
FEF08_RS11305	COG1098	S1 RNA binding domain
FEF08_RS11310	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FEF08_RS11320	COG0492	ferredoxin-NADP+ reductase activity
FEF08_RS11325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FEF08_RS11340	COG4470	Protein conserved in bacteria
FEF08_RS11345	COG0737	Belongs to the 5'-nucleotidase family
FEF08_RS11360	COG0590	tRNA wobble adenosine to inosine editing
FEF08_RS11365	COG2508	Transcriptional regulator
FEF08_RS11375	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FEF08_RS11375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FEF08_RS11390	COG2738	Putative neutral zinc metallopeptidase
FEF08_RS11395	COG2824	Alkylphosphonate utilization operon protein PhnA
FEF08_RS11400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FEF08_RS11405	COG4109	DRTGG domain
FEF08_RS11410	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FEF08_RS11430	COG0577	efflux transmembrane transporter activity
FEF08_RS11435	COG1136	(ABC) transporter
FEF08_RS11445	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FEF08_RS11450	COG1288	antiporter activity
FEF08_RS11455	COG4821	SIS domain
FEF08_RS11475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FEF08_RS11480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FEF08_RS11485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FEF08_RS11490	COG3716	PTS system mannose fructose sorbose family IID component
FEF08_RS11495	COG3715	PTS system
FEF08_RS11520	COG1132	(ABC) transporter
FEF08_RS11525	COG1132	(ABC) transporter
FEF08_RS11535	COG1803	Methylglyoxal synthase
FEF08_RS11540	COG3842	ATPase activity
FEF08_RS11550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FEF08_RS11555	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FEF08_RS11560	COG0084	hydrolase, TatD family'
FEF08_RS11565	COG0531	amino acid
FEF08_RS11580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEF08_RS11580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FEF08_RS11600	COG0675	Transposase, IS605 OrfB family
FEF08_RS11605	COG4608	Belongs to the ABC transporter superfamily
FEF08_RS11610	COG0444	Belongs to the ABC transporter superfamily
FEF08_RS11615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FEF08_RS11620	COG0601	transmembrane transport
FEF08_RS11630	COG4166	transmembrane transport
FEF08_RS11655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FEF08_RS11660	COG1674	ftsk spoiiie
FEF08_RS11660	COG1280	lysine exporter protein (LysE YggA)
FEF08_RS11665	COG2723	6-phospho-beta-galactosidase activity
FEF08_RS11675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FEF08_RS11680	COG1126	abc transporter atp-binding protein
FEF08_RS11685	COG0765	amino acid transport
FEF08_RS11745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FEF08_RS11755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FEF08_RS11760	COG0009	L-threonylcarbamoyladenylate synthase
FEF08_RS11770	COG2890	protein-(glutamine-N5) methyltransferase activity
FEF08_RS11775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FEF08_RS11780	COG1435	thymidine kinase activity
FEF08_RS11790	COG2226	methyltransferase
FEF08_RS11795	COG0681	Belongs to the peptidase S26 family
FEF08_RS11815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FEF08_RS11820	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FEF08_RS11825	COG3442	glutamine amidotransferase
FEF08_RS11830	COG0246	Mannitol dehydrogenase
FEF08_RS11835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEF08_RS11840	COG2213	PTS system mannitol-specific
FEF08_RS11845	COG1131	(ABC) transporter
FEF08_RS11855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEF08_RS11860	COG3711	transcriptional antiterminator
FEF08_RS11865	COG2213	PTS system mannitol-specific
FEF08_RS11870	COG1482	cell wall glycoprotein biosynthetic process
FEF08_RS11895	COG1132	(ABC) transporter
FEF08_RS11915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FEF08_RS11920	COG0628	permease
FEF08_RS11930	COG2706	6-phosphogluconolactonase activity
FEF08_RS11940	COG1368	sulfuric ester hydrolase activity
FEF08_RS11950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FEF08_RS11955	COG2160	L-arabinose isomerase activity
FEF08_RS11960	COG0235	Class ii aldolase
FEF08_RS11980	COG3940	Belongs to the glycosyl hydrolase 43 family
FEF08_RS11995	COG0395	ABC-type sugar transport system, permease component
FEF08_RS12000	COG1175	transmembrane transport
FEF08_RS12020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FEF08_RS12025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FEF08_RS12040	COG0789	Transcriptional regulator
FEF08_RS12045	COG1609	Transcriptional regulator
FEF08_RS12060	COG0459	protein refolding
FEF08_RS12065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FEF08_RS12075	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS12080	COG2910	NAD(P)H-binding
FEF08_RS12085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FEF08_RS12100	COG5002	protein histidine kinase activity
FEF08_RS12105	COG0745	RESPONSE REGULATOR receiver
FEF08_RS12110	COG1307	EDD domain protein, DegV family
FEF08_RS12150	COG4175	Glycine betaine
FEF08_RS12150	COG3448	diguanylate cyclase activity
FEF08_RS12180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FEF08_RS12185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FEF08_RS12195	COG0628	permease
FEF08_RS12200	COG1285	pathogenesis
FEF08_RS12205	COG0363	glucosamine-6-phosphate deaminase activity
FEF08_RS12210	COG0488	(ABC) transporter
FEF08_RS12225	COG2814	Major facilitator Superfamily
FEF08_RS12235	COG0222	ribosome binding
FEF08_RS12240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FEF08_RS12245	COG0081	regulation of translation
FEF08_RS12250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FEF08_RS12255	COG1760	l-serine dehydratase
FEF08_RS12260	COG1760	l-serine dehydratase
FEF08_RS12265	COG1304	FMN binding
FEF08_RS12270	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FEF08_RS12275	COG0250	Participates in transcription elongation, termination and antitermination
FEF08_RS12280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FEF08_RS12285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FEF08_RS12300	COG1597	lipid kinase activity
FEF08_RS12315	COG1131	(ABC) transporter
FEF08_RS12320	COG4585	Histidine kinase
FEF08_RS12325	COG2197	response regulator
FEF08_RS12335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FEF08_RS12345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FEF08_RS12350	COG2226	methyltransferase
FEF08_RS12355	COG3142	Participates in the control of copper homeostasis
FEF08_RS12360	COG2239	Acts as a magnesium transporter
FEF08_RS12365	COG0564	pseudouridine synthase activity
FEF08_RS12370	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FEF08_RS12375	COG2357	RelA SpoT domain protein
FEF08_RS12380	COG4116	CYTH
FEF08_RS12405	COG4862	establishment of competence for transformation
FEF08_RS12410	COG1393	Belongs to the ArsC family
FEF08_RS12425	COG0419	ATPase involved in DNA repair
FEF08_RS12430	COG0420	3'-5' exonuclease activity
FEF08_RS12435	COG0204	Acyl-transferase
FEF08_RS12440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FEF08_RS12445	COG2827	Endonuclease containing a URI domain
FEF08_RS12450	COG2755	lipolytic protein G-D-S-L family
FEF08_RS12450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FEF08_RS12460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FEF08_RS12465	COG0124	histidyl-tRNA synthetase
FEF08_RS12475	COG0667	Aldo Keto reductase
FEF08_RS12480	COG2124	cytochrome p450
FEF08_RS12485	COG1490	D-aminoacyl-tRNA deacylase activity
FEF08_RS12490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FEF08_RS12500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FEF08_RS12505	COG2264	protein methyltransferase activity
FEF08_RS12535	COG0589	response to stress
FEF08_RS12545	COG0488	(ABC) transporter
FEF08_RS12550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FEF08_RS12555	COG0827	DNA restriction-modification system
FEF08_RS12580	COG4537	Required for transformation and DNA binding
FEF08_RS12585	COG1459	type II secretion system
FEF08_RS12590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FEF08_RS12595	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
FEF08_RS12600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FEF08_RS12610	COG4473	ABC transporter
FEF08_RS12615	COG1131	(ABC) transporter
FEF08_RS12620	COG0537	adenosine 5'-monophosphoramidase activity
FEF08_RS12630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FEF08_RS12635	COG3481	metal-dependent phosphohydrolase, HD sub domain
FEF08_RS12640	COG4717	serine-type aminopeptidase activity
FEF08_RS12655	COG0561	phosphatase activity
FEF08_RS12685	COG2211	Major facilitator Superfamily
FEF08_RS12690	COG3507	Belongs to the glycosyl hydrolase 43 family
FEF08_RS12705	COG1073	alpha beta
FEF08_RS12720	COG1653	transport
FEF08_RS12730	COG4209	transmembrane transport
FEF08_RS12745	COG2207	Transcriptional regulator
FEF08_RS12750	COG1609	Transcriptional regulator
FEF08_RS12760	COG2721	sulfolactate sulfo-lyase activity
FEF08_RS12765	COG1904	glucuronate isomerase
FEF08_RS12770	COG2755	lipolytic protein G-D-S-L family
FEF08_RS12780	COG1132	(ABC) transporter
FEF08_RS12785	COG3679	Belongs to the UPF0342 family
FEF08_RS12790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FEF08_RS12795	COG0564	pseudouridine synthase activity
FEF08_RS12800	COG1940	carbohydrate kinase activity
FEF08_RS12805	COG0383	alpha-mannosidase activity
FEF08_RS12830	COG2207	Transcriptional regulator
FEF08_RS12830	COG4753	response regulator
FEF08_RS12835	COG2972	Histidine kinase
FEF08_RS12850	COG1653	transport
FEF08_RS12855	COG0395	ABC-type sugar transport system, permease component
FEF08_RS12860	COG1175	transmembrane transport
FEF08_RS12870	COG1187	pseudouridine synthase activity
FEF08_RS12875	COG2244	polysaccharide biosynthetic process
FEF08_RS12885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FEF08_RS12890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FEF08_RS12905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEF08_RS12905	COG3711	transcriptional antiterminator
FEF08_RS12950	COG4978	Transcriptional regulator
FEF08_RS12950	COG0789	Transcriptional regulator
FEF08_RS12960	COG1132	(ABC) transporter
FEF08_RS12975	COG0495	leucyl-tRNA aminoacylation
FEF08_RS12980	COG1388	LysM domain
FEF08_RS12980	COG1705	Flagellar rod assembly protein muramidase FlgJ
FEF08_RS12985	COG0671	phosphoesterase, PA-phosphatase related
FEF08_RS12990	COG1242	4 iron, 4 sulfur cluster binding
FEF08_RS12995	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FEF08_RS13000	COG1132	(ABC) transporter
FEF08_RS13005	COG1132	(ABC) transporter
FEF08_RS13020	COG0477	Major facilitator Superfamily
FEF08_RS13025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FEF08_RS13180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FEF08_RS13185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FEF08_RS13190	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FEF08_RS13200	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FEF08_RS13205	COG0037	tRNA processing
FEF08_RS13210	COG1098	S1 RNA binding domain
FEF08_RS13220	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FEF08_RS13225	COG2244	polysaccharide biosynthetic process
FEF08_RS13230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FEF08_RS13235	COG0193	aminoacyl-tRNA hydrolase activity
FEF08_RS13240	COG0039	L-malate dehydrogenase activity
FEF08_RS13250	COG0217	transcriptional regulatory protein
FEF08_RS13275	COG1792	Involved in formation and maintenance of cell shape
FEF08_RS13285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FEF08_RS13290	COG1162	GTPase activity
FEF08_RS13295	COG0515	serine threonine protein kinase
FEF08_RS13295	COG2815	serine threonine protein kinase
FEF08_RS13300	COG0631	protein serine/threonine phosphatase activity
FEF08_RS13305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FEF08_RS13305	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FEF08_RS13310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FEF08_RS13315	COG0242	peptide deformylase activity
FEF08_RS13320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FEF08_RS13325	COG1758	RNA polymerase activity
FEF08_RS13330	COG0194	GDP metabolic process
FEF08_RS13340	COG1561	YicC-like family, N-terminal region
FEF08_RS13350	COG1752	Esterase of the alpha-beta hydrolase superfamily
FEF08_RS13365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FEF08_RS13370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FEF08_RS13375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FEF08_RS13380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FEF08_RS13385	COG1121	(ABC) transporter
FEF08_RS13390	COG0803	Belongs to the bacterial solute-binding protein 9 family
FEF08_RS13390	COG3443	Belongs to the bacterial solute-binding protein 9 family
FEF08_RS13395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FEF08_RS13400	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FEF08_RS13400	COG0392	lysyltransferase activity
FEF08_RS13405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FEF08_RS13410	COG1418	mRNA catabolic process
FEF08_RS13415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FEF08_RS13420	COG1058	Belongs to the CinA family
FEF08_RS13420	COG1546	Belongs to the CinA family
FEF08_RS13425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FEF08_RS13435	COG1426	Protein conserved in bacteria
FEF08_RS13440	COG0612	Peptidase, M16
FEF08_RS13445	COG0612	Peptidase, M16
FEF08_RS13450	COG1970	mechanosensitive ion channel activity
FEF08_RS13455	COG2153	protein acetylation
FEF08_RS13460	COG4466	Protein conserved in bacteria
FEF08_RS13470	COG3688	RNA-binding protein containing a PIN domain
FEF08_RS13475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FEF08_RS13480	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FEF08_RS13485	COG0215	cysteine-tRNA ligase activity
FEF08_RS13490	COG1045	serine acetyltransferase
FEF08_RS13495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FEF08_RS13500	COG4956	integral membrane protein (PIN domain superfamily)
FEF08_RS13510	COG0756	dUTP diphosphatase activity
FEF08_RS13515	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FEF08_RS13520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FEF08_RS13570	COG0778	Nitroreductase
FEF08_RS13580	COG1705	Flagellar rod assembly protein muramidase FlgJ
FEF08_RS13580	COG1388	LysM domain
FEF08_RS13585	COG4221	oxidoreductase activity
FEF08_RS13595	COG0583	DNA-binding transcription factor activity
FEF08_RS13600	COG3711	transcriptional antiterminator
FEF08_RS13605	COG2190	(PTS) system
FEF08_RS13605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS13605	COG1263	PTS System
FEF08_RS13610	COG0702	epimerase
FEF08_RS13625	COG3708	Transcriptional regulator
FEF08_RS13625	COG2207	Transcriptional regulator
FEF08_RS13640	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FEF08_RS13650	COG0604	alcohol dehydrogenase
FEF08_RS13665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FEF08_RS13675	COG0842	Transport permease protein
FEF08_RS13680	COG1131	(ABC) transporter
FEF08_RS13690	COG2205	protein histidine kinase activity
FEF08_RS13695	COG0745	RESPONSE REGULATOR receiver
FEF08_RS13740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEF08_RS13745	COG3716	PTS system mannose fructose sorbose family IID component
FEF08_RS13750	COG3715	PTS system
FEF08_RS13760	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FEF08_RS13765	COG2222	sugar isomerase
FEF08_RS13780	COG1263	PTS System
FEF08_RS13780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS13785	COG1737	Transcriptional regulator
FEF08_RS13895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FEF08_RS13900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FEF08_RS13905	COG0783	Belongs to the Dps family
FEF08_RS13910	COG1070	Carbohydrate kinase
FEF08_RS13915	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FEF08_RS13920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FEF08_RS13925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEF08_RS13935	COG1554	hydrolase, family 65, central catalytic
FEF08_RS13940	COG0673	inositol 2-dehydrogenase activity
FEF08_RS13945	COG1082	Xylose isomerase domain protein TIM barrel
FEF08_RS13950	COG1063	alcohol dehydrogenase
FEF08_RS13955	COG0395	ABC-type sugar transport system, permease component
FEF08_RS13960	COG1175	transmembrane transport
FEF08_RS13965	COG1653	transport
FEF08_RS13970	COG0366	Alpha amylase catalytic
FEF08_RS13975	COG1609	Transcriptional regulator
FEF08_RS13980	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FEF08_RS13985	COG0085	RNA polymerase activity
FEF08_RS14000	COG4120	Belongs to the binding-protein-dependent transport system permease family
FEF08_RS14015	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FEF08_RS14015	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FEF08_RS14030	COG0142	geranyltranstransferase activity
FEF08_RS14050	COG4939	FMN-binding domain protein
FEF08_RS14070	COG0826	peptidase U32
FEF08_RS14075	COG0826	peptidase U32
FEF08_RS14080	COG0542	response to heat
FEF08_RS14085	COG4463	regulation of RNA biosynthetic process
FEF08_RS14165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FEF08_RS14175	COG0517	IMP dehydrogenase activity
FEF08_RS14175	COG0516	GMP reductase activity
FEF08_RS14190	COG0012	GTP binding
FEF08_RS14195	COG4481	Protein conserved in bacteria
FEF08_RS14200	COG1475	DNA binding
FEF08_RS14205	COG1192	Involved in chromosome partitioning
FEF08_RS14210	COG0357	Ribosomal RNA small subunit methyltransferase G
FEF08_RS14215	COG0445	tRNA wobble uridine modification
FEF08_RS14220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FEF08_RS14230	COG1847	R3H domain protein
FEF08_RS14235	COG0706	membrane insertase activity
FEF08_RS14240	COG0594	ribonuclease P activity
FEF08_RS14245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FEF08_RS14380	COG3344	reverse transcriptase
FEF08_RS14470	COG0456	acetyltransferase
FEF08_RS14480	COG0456	acetyltransferase
FEF08_RS14505	COG4372	Transposase
FEF08_RS14520	COG4372	Transposase
FEF08_RS14625	COG0629	single-stranded DNA binding
FEF08_RS14630	COG0629	single-stranded DNA binding
FEF08_RS14705	COG3328	transposase activity
FEF08_RS14720	COG3775	system Galactitol-specific IIC component
FEF08_RS14735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FEF08_RS14745	COG4372	Transposase
FEF08_RS14785	COG1940	carbohydrate kinase activity
FEF08_RS14790	COG2826	transposase and inactivated derivatives, IS30 family
FEF08_RS14795	COG2190	(PTS) system
FEF08_RS14795	COG1263	PTS System
FEF08_RS14795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS14800	COG1621	beta-fructofuranosidase activity
FEF08_RS14805	COG1609	Transcriptional regulator
FEF08_RS14840	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FEF08_RS14845	COG2190	(PTS) system
FEF08_RS14845	COG1263	PTS System
FEF08_RS14845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS14850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FEF08_RS14850	COG1263	PTS System
FEF08_RS14850	COG2190	(PTS) system
FEF08_RS14895	COG4974	Belongs to the 'phage' integrase family
FEF08_RS14920	COG0366	Alpha amylase catalytic
FEF08_RS14925	COG0366	Alpha amylase catalytic
FEF08_RS14935	COG0395	ABC-type sugar transport system, permease component
FEF08_RS14940	COG1175	transmembrane transport
FEF08_RS14945	COG1653	transport
FEF08_RS14950	COG1486	melibiose metabolic process
FEF08_RS14955	COG0395	ABC-type sugar transport system, permease component
FEF08_RS14970	COG1609	Transcriptional regulator
FEF08_RS14975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FEF08_RS14985	COG0346	lactoylglutathione lyase activity
FEF08_RS14995	COG0582	viral genome integration into host DNA
FEF08_RS15000	COG3328	transposase activity
FEF08_RS15115	COG1940	carbohydrate kinase activity
FEF08_RS15125	COG0395	ABC-type sugar transport system, permease component
FEF08_RS15130	COG1175	transmembrane transport
FEF08_RS15140	COG1609	Transcriptional regulator
FEF08_RS15190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FEF08_RS15220	COG0431	NADPH-dependent FMN reductase
FEF08_RS15220	COG3976	FMN-binding domain protein
FEF08_RS15220	COG1053	succinate dehydrogenase
FEF08_RS15250	COG1288	antiporter activity
FEF08_RS15270	COG2188	Transcriptional regulator
FEF08_RS15275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FEF08_RS15280	COG2222	sugar isomerase
FEF08_RS15300	COG4372	Transposase
FEF08_RS15325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FEF08_RS15330	COG3933	PFAM sigma-54 factor interaction domain-containing protein
FEF08_RS15330	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FEF08_RS15335	COG2222	sugar isomerase
FEF08_RS15340	COG3716	PTS system mannose fructose sorbose family IID component
FEF08_RS15345	COG3715	PTS system
FEF08_RS15390	COG3328	transposase activity
FEF08_RS15415	COG3716	PTS system mannose fructose sorbose family IID component
FEF08_RS15420	COG3715	PTS system
FEF08_RS15440	COG2188	Transcriptional regulator
FEF08_RS15445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FEF08_RS15525	COG0629	single-stranded DNA binding
FEF08_RS15560	COG5002	protein histidine kinase activity
FEF08_RS15580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FEF08_RS15595	COG3842	ATPase activity
FEF08_RS15605	COG0395	ABC-type sugar transport system, permease component
FEF08_RS15620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FEF08_RS15645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FEF08_RS15660	COG1136	(ABC) transporter
FEF08_RS15750	COG2207	Transcriptional regulator