locus-tag	class	description
I6I82_RS00025	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6I82_RS00165	COG1192	Involved in chromosome partitioning
I6I82_RS00180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I82_RS00220	COG0629	single-stranded DNA binding
I6I82_RS00380	COG0629	single-stranded DNA binding
I6I82_RS00635	COG0489	protein tyrosine kinase activity
I6I82_RS00710	COG1764	response to oxidative stress
I6I82_RS00715	COG3583	domain protein
I6I82_RS00730	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I82_RS00775	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6I82_RS00775	COG0392	lysyltransferase activity
I6I82_RS00780	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6I82_RS00785	COG0582	viral genome integration into host DNA
I6I82_RS00790	COG4974	Belongs to the 'phage' integrase family
I6I82_RS00795	COG1122	ATPase activity
I6I82_RS00805	COG0310	cobalt ion transport
I6I82_RS00810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I82_RS00815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I82_RS00820	COG0829	nickel cation binding
I6I82_RS00840	COG0804	urea catabolic process
I6I82_RS01035	COG1388	LysM domain
I6I82_RS01035	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6I82_RS01165	COG3177	Filamentation induced by cAMP protein fic
I6I82_RS01195	COG3041	Addiction module toxin RelE StbE family
I6I82_RS01300	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6I82_RS01370	COG1192	Involved in chromosome partitioning
I6I82_RS01385	COG3964	amidohydrolase
I6I82_RS01415	COG1428	Deoxynucleoside kinase
I6I82_RS01430	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS01440	COG1175	transmembrane transport
I6I82_RS01445	COG0395	ABC-type sugar transport system, permease component
I6I82_RS01460	COG0737	Belongs to the 5'-nucleotidase family
I6I82_RS01475	COG1368	sulfuric ester hydrolase activity
I6I82_RS01485	COG0105	UTP biosynthetic process
I6I82_RS01490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I82_RS01495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I82_RS01505	COG2011	ABC-type metal ion transport system permease component
I6I82_RS01510	COG1464	Belongs to the NlpA lipoprotein family
I6I82_RS01515	COG1473	amidohydrolase
I6I82_RS01520	COG1757	Na H antiporter
I6I82_RS01530	COG1113	amino acid transport
I6I82_RS01545	COG0004	ammonium transporteR
I6I82_RS01550	COG0531	amino acid
I6I82_RS01565	COG1929	Belongs to the glycerate kinase type-1 family
I6I82_RS01570	COG0488	(ABC) transporter
I6I82_RS01585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6I82_RS01590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS01590	COG1263	PTS System
I6I82_RS01625	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I82_RS01635	COG3201	nicotinamide mononucleotide transporter
I6I82_RS01640	COG0346	lactoylglutathione lyase activity
I6I82_RS01670	COG0561	phosphatase activity
I6I82_RS01675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I82_RS01680	COG0280	phosphate acetyltransferase
I6I82_RS01685	COG0802	atpase or kinase
I6I82_RS01690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I82_RS01705	COG0708	Exodeoxyribonuclease III
I6I82_RS01715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I82_RS01720	COG0456	acetyltransferase
I6I82_RS01720	COG0454	-acetyltransferase
I6I82_RS01740	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6I82_RS01745	COG0604	alcohol dehydrogenase
I6I82_RS01745	COG1028	Short-chain dehydrogenase reductase Sdr
I6I82_RS01745	COG3321	synthase
I6I82_RS01750	COG0702	epimerase
I6I82_RS01755	COG4684	Psort location CytoplasmicMembrane, score
I6I82_RS01760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I82_RS01770	COG0604	alcohol dehydrogenase
I6I82_RS01780	COG3842	ATPase activity
I6I82_RS01785	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I82_RS01790	COG1177	transmembrane transport
I6I82_RS01800	COG4978	Transcriptional regulator
I6I82_RS01800	COG0789	Transcriptional regulator
I6I82_RS01820	COG0582	viral genome integration into host DNA
I6I82_RS01860	COG1846	Transcriptional regulator
I6I82_RS01865	COG1132	(ABC) transporter
I6I82_RS01870	COG5002	protein histidine kinase activity
I6I82_RS01875	COG0745	RESPONSE REGULATOR receiver
I6I82_RS01880	COG0577	efflux transmembrane transporter activity
I6I82_RS01885	COG1136	(ABC) transporter
I6I82_RS01895	COG0488	(ABC) transporter
I6I82_RS01900	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6I82_RS01910	COG0602	queuosine metabolic process
I6I82_RS01915	COG1328	CTP reductase activity
I6I82_RS01920	COG1136	(ABC) transporter
I6I82_RS01925	COG0577	efflux transmembrane transporter activity
I6I82_RS01935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I82_RS01940	COG1696	Membrane protein involved in D-alanine export
I6I82_RS01945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I82_RS01950	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6I82_RS01955	COG1363	Peptidase, m42
I6I82_RS01965	COG1234	tRNA 3'-trailer cleavage
I6I82_RS01970	COG0095	Lipoate-protein ligase
I6I82_RS01995	COG3759	membrane
I6I82_RS02000	COG0659	secondary active sulfate transmembrane transporter activity
I6I82_RS02010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I82_RS02020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I82_RS02025	COG3594	Acyltransferase
I6I82_RS02030	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6I82_RS02030	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6I82_RS02035	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS02035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS02045	COG3715	PTS system
I6I82_RS02050	COG3716	PTS system mannose fructose sorbose family IID component
I6I82_RS02060	COG2261	transglycosylase associated protein
I6I82_RS02065	COG0006	proline dipeptidase activity
I6I82_RS02070	COG1302	Protein conserved in bacteria
I6I82_RS02075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I82_RS02080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I82_RS02085	COG1570	exodeoxyribonuclease VII activity
I6I82_RS02090	COG1722	exodeoxyribonuclease VII activity
I6I82_RS02095	COG0142	geranyltranstransferase activity
I6I82_RS02100	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6I82_RS02105	COG1438	arginine binding
I6I82_RS02110	COG0497	DNA recombination
I6I82_RS02140	COG4839	cell division protein FtsL
I6I82_RS02145	COG0768	penicillin binding
I6I82_RS02180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I82_RS02185	COG1799	cell septum assembly
I6I82_RS02190	COG0762	integral membrane protein
I6I82_RS02195	COG2302	S4 RNA-binding domain
I6I82_RS02200	COG3599	regulation of cell shape
I6I82_RS02205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I82_RS02210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I82_RS02215	COG1321	iron dependent repressor
I6I82_RS02215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I82_RS02230	COG0673	inositol 2-dehydrogenase activity
I6I82_RS02245	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS02255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS02295	COG2309	aminopeptidase activity
I6I82_RS02305	COG0716	FMN binding
I6I82_RS02310	COG0024	Methionine aminopeptidase
I6I82_RS02315	COG1295	ribonuclease BN
I6I82_RS02320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I82_RS02335	COG1215	transferase activity, transferring glycosyl groups
I6I82_RS02340	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6I82_RS02345	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I6I82_RS02350	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I82_RS02355	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6I82_RS02370	COG1682	transport, permease protein
I6I82_RS02380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I82_RS02385	COG0438	transferase activity, transferring glycosyl groups
I6I82_RS02385	COG1216	Glycosyl transferase, family 2
I6I82_RS02390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I82_RS02395	COG1216	Glycosyl transferase, family 2
I6I82_RS02400	COG3475	LICD family
I6I82_RS02415	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I82_RS02420	COG1216	Glycosyl transferase, family 2
I6I82_RS02430	COG3475	LICD family
I6I82_RS02450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I82_RS02455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I82_RS02460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I82_RS02470	COG4585	Histidine kinase
I6I82_RS02480	COG0569	domain protein
I6I82_RS02485	COG4841	protein insertion into membrane
I6I82_RS02500	COG2246	polysaccharide biosynthetic process
I6I82_RS02505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I82_RS02540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I82_RS02545	COG1316	TRANSCRIPTIONal
I6I82_RS02550	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I6I82_RS02560	COG3397	chitin binding
I6I82_RS02570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I82_RS02575	COG2137	regulation of response to DNA damage stimulus
I6I82_RS02580	COG1194	a g-specific adenine glycosylase
I6I82_RS02585	COG3557	Belongs to the UPF0374 family
I6I82_RS02595	COG0628	permease
I6I82_RS02600	COG1253	flavin adenine dinucleotide binding
I6I82_RS02605	COG5492	domain, Protein
I6I82_RS02610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I82_RS02615	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I82_RS02630	COG0542	response to heat
I6I82_RS02635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS02640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I82_RS02650	COG0438	transferase activity, transferring glycosyl groups
I6I82_RS02655	COG2084	Dehydrogenase
I6I82_RS02660	COG4703	Protein of unknown function (DUF1797)
I6I82_RS02670	COG1846	Transcriptional regulator
I6I82_RS02675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I82_RS02685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I82_RS02705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I82_RS02710	COG0439	Biotin carboxylase
I6I82_RS02715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I82_RS02720	COG0825	malonyl-CoA metabolic process
I6I82_RS02745	COG1126	abc transporter atp-binding protein
I6I82_RS02755	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6I82_RS02760	COG1534	Rna-binding protein
I6I82_RS02765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I82_RS02770	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6I82_RS02775	COG0799	negative regulation of ribosome biogenesis
I6I82_RS02780	COG2226	methyltransferase
I6I82_RS02785	COG1323	Belongs to the UPF0348 family
I6I82_RS02790	COG0217	transcriptional regulatory protein
I6I82_RS02800	COG3973	AAA domain
I6I82_RS02810	COG1942	4-Oxalocrotonate Tautomerase
I6I82_RS02815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I82_RS02825	COG1737	Transcriptional regulator
I6I82_RS02830	COG0768	penicillin binding
I6I82_RS02835	COG0561	phosphatase activity
I6I82_RS02840	COG2252	PERMEase
I6I82_RS02845	COG2814	Major facilitator Superfamily
I6I82_RS02855	COG0587	DNA-directed DNA polymerase activity
I6I82_RS02860	COG0205	6-phosphofructokinase activity
I6I82_RS02870	COG0583	DNA-binding transcription factor activity
I6I82_RS02880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I82_RS02885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I82_RS02890	COG0745	RESPONSE REGULATOR receiver
I6I82_RS02895	COG5002	protein histidine kinase activity
I6I82_RS03005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I82_RS03015	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I82_RS03020	COG0351	phosphomethylpyrimidine kinase
I6I82_RS03020	COG0352	thiamine-phosphate diphosphorylase activity
I6I82_RS03035	COG3732	PTS system glucitol sorbitol-specific
I6I82_RS03045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I82_RS03080	COG0346	lactoylglutathione lyase activity
I6I82_RS03085	COG2188	Transcriptional regulator
I6I82_RS03090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS03095	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS03110	COG0589	response to stress
I6I82_RS03115	COG0351	phosphomethylpyrimidine kinase
I6I82_RS03125	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I82_RS03130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS03130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS03130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS03140	COG3684	Belongs to the aldolase LacD family
I6I82_RS03175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I82_RS03190	COG3425	synthase
I6I82_RS03195	COG0183	Belongs to the thiolase family
I6I82_RS03200	COG0772	Belongs to the SEDS family
I6I82_RS03205	COG0671	phosphoesterase, PA-phosphatase related
I6I82_RS03220	COG0656	L-ascorbic acid biosynthetic process
I6I82_RS03230	COG0346	lactoylglutathione lyase activity
I6I82_RS03245	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6I82_RS03245	COG0392	lysyltransferase activity
I6I82_RS03255	COG0741	lytic transglycosylase activity
I6I82_RS03265	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I82_RS03270	COG0358	DNA primase activity
I6I82_RS03275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I82_RS03285	COG2996	Protein conserved in bacteria
I6I82_RS03290	COG0735	belongs to the Fur family
I6I82_RS03295	COG4974	Belongs to the 'phage' integrase family
I6I82_RS03305	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I82_RS03310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I82_RS03315	COG1187	pseudouridine synthase activity
I6I82_RS03320	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6I82_RS03325	COG1288	antiporter activity
I6I82_RS03330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I82_RS03340	COG1141	Ferredoxin
I6I82_RS03350	COG0514	ATP-dependent DNA helicase (RecQ)
I6I82_RS03355	COG3942	CHAP domain
I6I82_RS03355	COG1388	LysM domain
I6I82_RS03360	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I82_RS03365	COG0539	negative regulation of cytoplasmic translation
I6I82_RS03370	COG1940	carbohydrate kinase activity
I6I82_RS03375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS03375	COG1263	PTS System
I6I82_RS03375	COG2190	(PTS) system
I6I82_RS03380	COG1621	beta-fructofuranosidase activity
I6I82_RS03385	COG1609	Transcriptional regulator
I6I82_RS03390	COG1160	GTP binding
I6I82_RS03395	COG0776	regulation of translation
I6I82_RS03400	COG0582	viral genome integration into host DNA
I6I82_RS03415	COG0457	Tetratricopeptide repeat
I6I82_RS03420	COG5582	Belongs to the UPF0302 family
I6I82_RS03425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I82_RS03430	COG1694	Mazg nucleotide pyrophosphohydrolase
I6I82_RS03435	COG0617	tRNA 3'-terminal CCA addition
I6I82_RS03450	COG0025	NhaP-type Na H and K H
I6I82_RS03470	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
I6I82_RS03475	COG0488	(ABC) transporter
I6I82_RS03480	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I82_RS03490	COG1307	EDD domain protein, DegV family
I6I82_RS03495	COG2755	lipolytic protein G-D-S-L family
I6I82_RS03500	COG4698	Protein conserved in bacteria
I6I82_RS03510	COG4479	Belongs to the UPF0346 family
I6I82_RS03515	COG0681	Belongs to the peptidase S26 family
I6I82_RS03520	COG0095	Lipoate-protein ligase
I6I82_RS03540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6I82_RS03545	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I82_RS03550	COG0758	DNA mediated transformation
I6I82_RS03555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I82_RS03560	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6I82_RS03565	COG4974	Belongs to the 'phage' integrase family
I6I82_RS03570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I82_RS03575	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I82_RS03580	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6I82_RS03590	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I82_RS03595	COG1832	CoA-binding protein
I6I82_RS03600	COG0187	DNA topoisomerase II activity
I6I82_RS03610	COG1882	Formate acetyltransferase
I6I82_RS03615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I82_RS03625	COG1349	DNA-binding transcription factor activity
I6I82_RS03630	COG2207	Transcriptional regulator
I6I82_RS03660	COG4209	transmembrane transport
I6I82_RS03665	COG0395	ABC-type sugar transport system, permease component
I6I82_RS03675	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS03680	COG1227	inorganic diphosphatase activity
I6I82_RS03705	COG1609	Transcriptional regulator
I6I82_RS03715	COG0604	alcohol dehydrogenase
I6I82_RS03720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I82_RS03730	COG1732	Glycine betaine
I6I82_RS03775	COG3942	CHAP domain
I6I82_RS03775	COG1388	LysM domain
I6I82_RS03795	COG0436	Aminotransferase
I6I82_RS03840	COG3623	hexulose-6-phosphate isomerase
I6I82_RS03855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I82_RS03865	COG2268	Band 7 protein
I6I82_RS03875	COG4129	membrane
I6I82_RS03890	COG1876	peptidase activity
I6I82_RS03905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I82_RS03910	COG2233	PERMEase
I6I82_RS03925	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I82_RS03930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I82_RS03935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I82_RS03945	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I82_RS03950	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I82_RS03955	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I82_RS03960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I82_RS03970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I82_RS03975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I82_RS03980	COG0138	bifunctional purine biosynthesis protein purh
I6I82_RS03985	COG0151	Belongs to the GarS family
I6I82_RS03990	COG4989	oxidoreductase activity
I6I82_RS04000	COG0516	GMP reductase activity
I6I82_RS04005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I82_RS04015	COG0022	dehydrogenase e1 component
I6I82_RS04035	COG4476	Belongs to the UPF0223 family
I6I82_RS04040	COG0483	inositol monophosphate 1-phosphatase activity
I6I82_RS04045	COG1217	gtp-binding protein TYPA
I6I82_RS04050	COG0514	ATP-dependent DNA helicase (RecQ)
I6I82_RS04055	COG4838	Belongs to the UPF0358 family
I6I82_RS04060	COG0772	Belongs to the SEDS family
I6I82_RS04065	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6I82_RS04075	COG3679	Belongs to the UPF0342 family
I6I82_RS04080	COG4471	UPF0298 protein
I6I82_RS04085	COG0742	ribosomal rna small subunit methyltransferase
I6I82_RS04090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I82_RS04095	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6I82_RS04110	COG2131	deaminase
I6I82_RS04115	COG0658	competence protein
I6I82_RS04115	COG2333	competence protein COMEC
I6I82_RS04120	COG1466	dna polymerase III delta subunit
I6I82_RS04125	COG0268	Binds directly to 16S ribosomal RNA
I6I82_RS04135	COG2707	UPF0756 membrane protein
I6I82_RS04140	COG2217	Heavy metal translocating P-type atpase
I6I82_RS04145	COG1968	undecaprenyl-diphosphatase activity
I6I82_RS04160	COG1199	ATP-dependent helicase activity
I6I82_RS04160	COG1199	ATP-dependent helicase activity
I6I82_RS04165	COG1666	GTP binding
I6I82_RS04170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I82_RS04175	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I82_RS04200	COG1388	LysM domain
I6I82_RS04200	COG3942	CHAP domain
I6I82_RS04245	COG4990	cell redox homeostasis
I6I82_RS04270	COG3104	oligopeptide transport
I6I82_RS04275	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6I82_RS04280	COG1074	ATP-dependent DNA helicase activity
I6I82_RS04285	COG1733	regulation of RNA biosynthetic process
I6I82_RS04290	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I82_RS04295	COG0072	phenylalanine-tRNA ligase activity
I6I82_RS04295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I82_RS04305	COG1126	abc transporter atp-binding protein
I6I82_RS04310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I82_RS04315	COG0765	amino acid transport
I6I82_RS04320	COG0765	amino acid transport
I6I82_RS04345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I82_RS04350	COG2096	Adenosyltransferase
I6I82_RS04365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I82_RS04385	COG0668	transmembrane transport
I6I82_RS04390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I82_RS04395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6I82_RS04400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I82_RS04405	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I82_RS04435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I82_RS04445	COG1234	tRNA 3'-trailer cleavage
I6I82_RS04450	COG0300	oxidoreductase activity
I6I82_RS04455	COG5416	Lipopolysaccharide assembly protein A domain
I6I82_RS04460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6I82_RS04460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I82_RS04465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I82_RS04475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I82_RS04480	COG4224	UPF0291 protein
I6I82_RS04490	COG1388	LysM domain
I6I82_RS04490	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6I82_RS04500	COG0735	belongs to the Fur family
I6I82_RS04505	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I82_RS04520	COG3935	DnaD domain protein
I6I82_RS04525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I82_RS04530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I82_RS04535	COG3331	DNA recombination
I6I82_RS04540	COG4474	Belongs to the UPF0398 family
I6I82_RS04545	COG3599	regulation of cell shape
I6I82_RS04555	COG0116	Belongs to the methyltransferase superfamily
I6I82_RS04560	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I6I82_RS04565	COG1418	mRNA catabolic process
I6I82_RS04575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I82_RS04580	COG0531	amino acid
I6I82_RS04595	COG0513	Belongs to the DEAD box helicase family
I6I82_RS04605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I82_RS04610	COG4684	Psort location CytoplasmicMembrane, score
I6I82_RS04620	COG0328	RNA-DNA hybrid ribonuclease activity
I6I82_RS04635	COG1278	Cold shock
I6I82_RS04640	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6I82_RS04665	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I82_RS04670	COG0564	pseudouridine synthase activity
I6I82_RS04680	COG2233	PERMEase
I6I82_RS04685	COG0540	Belongs to the ATCase OTCase family
I6I82_RS04690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I82_RS04695	COG0505	Belongs to the CarA family
I6I82_RS04700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I82_RS04705	COG0543	2 iron, 2 sulfur cluster binding
I6I82_RS04710	COG0167	dihydroorotate dehydrogenase activity
I6I82_RS04715	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I82_RS04755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I82_RS04760	COG2011	ABC-type metal ion transport system permease component
I6I82_RS04765	COG1464	Belongs to the NlpA lipoprotein family
I6I82_RS04770	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6I82_RS04785	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6I82_RS04790	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I82_RS04845	COG0039	L-malate dehydrogenase activity
I6I82_RS04860	COG0673	inositol 2-dehydrogenase activity
I6I82_RS04865	COG1737	Transcriptional regulator
I6I82_RS04900	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I82_RS04900	COG0352	thiamine-phosphate diphosphorylase activity
I6I82_RS04900	COG0351	phosphomethylpyrimidine kinase
I6I82_RS04910	COG4475	Protein of unknown function (DUF436)
I6I82_RS04915	COG0366	Alpha amylase catalytic
I6I82_RS04930	COG1307	EDD domain protein, DegV family
I6I82_RS04935	COG2244	polysaccharide biosynthetic process
I6I82_RS04975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I82_RS04980	COG0194	GDP metabolic process
I6I82_RS05000	COG0167	dihydroorotate dehydrogenase activity
I6I82_RS05015	COG2011	ABC-type metal ion transport system permease component
I6I82_RS05020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I82_RS05050	COG4656	Part of a membrane complex involved in electron transport
I6I82_RS05060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I82_RS05065	COG5521	maltodextrose utilization protein MalA
I6I82_RS05070	COG3833	ABC-type maltose transport systems, permease component
I6I82_RS05075	COG1175	transmembrane transport
I6I82_RS05080	COG2182	Extracellular solute-binding protein
I6I82_RS05085	COG0366	Alpha amylase catalytic
I6I82_RS05090	COG4948	Mandelate Racemase Muconate Lactonizing
I6I82_RS05100	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I82_RS05110	COG0318	PFAM AMP-dependent synthetase and ligase
I6I82_RS05115	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I82_RS05125	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I82_RS05130	COG1764	response to oxidative stress
I6I82_RS05135	COG1846	Transcriptional regulator
I6I82_RS05140	COG0628	permease
I6I82_RS05145	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6I82_RS05160	COG0450	alkyl hydroperoxide reductase
I6I82_RS05165	COG3634	alkyl hydroperoxide reductase activity
I6I82_RS05210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I82_RS05215	COG0666	response to abiotic stimulus
I6I82_RS05225	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I82_RS05235	COG2261	transglycosylase associated protein
I6I82_RS05260	COG4512	PFAM Accessory gene regulator B
I6I82_RS05265	COG3279	Response regulator of the LytR AlgR family
I6I82_RS05280	COG3655	Transcriptional regulator
I6I82_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
I6I82_RS05320	COG1442	glycosyl transferase family 8
I6I82_RS05325	COG1442	glycosyl transferase family 8
I6I82_RS05330	COG0561	phosphatase activity
I6I82_RS05355	COG1278	Cold shock
I6I82_RS05380	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS05390	COG1940	carbohydrate kinase activity
I6I82_RS05400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS05410	COG1278	Cold shock
I6I82_RS05425	COG0481	GTPase activity
I6I82_RS05445	COG0542	response to heat
I6I82_RS05460	COG1597	lipid kinase activity
I6I82_RS05465	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I82_RS05470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I82_RS05475	COG2384	SAM-dependent methyltransferase
I6I82_RS05485	COG1484	DNA-dependent DNA replication
I6I82_RS05495	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I82_RS05505	COG0237	dephospho-CoA kinase activity
I6I82_RS05510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I82_RS05515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I82_RS05515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I82_RS05530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I82_RS05535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6I82_RS05540	COG3091	SprT-like family
I6I82_RS05545	COG2183	response to ionizing radiation
I6I82_RS05550	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I82_RS05555	COG1054	Belongs to the UPF0176 family
I6I82_RS05575	COG0546	phosphoglycolate phosphatase activity
I6I82_RS05580	COG0588	phosphoglycerate mutase activity
I6I82_RS05620	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS05625	COG1940	carbohydrate kinase activity
I6I82_RS05630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS05645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I82_RS05650	COG1597	lipid kinase activity
I6I82_RS05655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I82_RS05660	COG0154	amidase activity
I6I82_RS05665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I82_RS05670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I82_RS05675	COG0210	DNA helicase
I6I82_RS05680	COG0038	chloride channel
I6I82_RS05705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS05705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS05705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS05710	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I82_RS05715	COG1349	DNA-binding transcription factor activity
I6I82_RS05730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I82_RS05735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I82_RS05740	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I82_RS05750	COG1714	RDD family
I6I82_RS05765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I82_RS05785	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6I82_RS05810	COG1481	regulation of sporulation
I6I82_RS05820	COG1660	Displays ATPase and GTPase activities
I6I82_RS05835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I82_RS05840	COG0556	nucleotide-excision repair
I6I82_RS05845	COG0765	amino acid transport
I6I82_RS05850	COG1126	abc transporter atp-binding protein
I6I82_RS05855	COG0484	heat shock protein binding
I6I82_RS05860	COG0443	Heat shock 70 kDa protein
I6I82_RS05865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I82_RS05870	COG1420	regulation of RNA biosynthetic process
I6I82_RS05875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I82_RS05910	COG0196	riboflavin kinase activity
I6I82_RS05915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I82_RS05920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I82_RS05935	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6I82_RS05940	COG0195	Participates in both transcription termination and antitermination
I6I82_RS05945	COG0779	Required for maturation of 30S ribosomal subunits
I6I82_RS05950	COG2176	DNA-directed DNA polymerase activity
I6I82_RS05955	COG1733	regulation of RNA biosynthetic process
I6I82_RS05960	COG0656	L-ascorbic acid biosynthetic process
I6I82_RS05970	COG0442	prolyl-tRNA aminoacylation
I6I82_RS05975	COG0750	zinc metalloprotease
I6I82_RS05980	COG4589	Belongs to the CDS family
I6I82_RS05985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I82_RS05990	COG0233	cytoplasmic translational termination
I6I82_RS05995	COG0528	UMP kinase activity
I6I82_RS06000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I82_RS06005	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I82_RS06010	COG1438	arginine binding
I6I82_RS06015	COG0018	arginyl-trna synthetase
I6I82_RS06030	COG2235	arginine
I6I82_RS06035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I82_RS06040	COG1215	transferase activity, transferring glycosyl groups
I6I82_RS06080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I82_RS06085	COG0456	acetyltransferase
I6I82_RS06095	COG1214	PFAM Peptidase M22, glycoprotease
I6I82_RS06100	COG1609	Transcriptional regulator
I6I82_RS06105	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6I82_RS06110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I82_RS06125	COG3189	MarR family transcriptional regulator
I6I82_RS06135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I82_RS06140	COG1940	carbohydrate kinase activity
I6I82_RS06150	COG0705	Rhomboid family
I6I82_RS06150	COG0457	Tetratricopeptide repeat
I6I82_RS06155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I82_RS06160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I82_RS06165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I82_RS06170	COG1120	ATPase activity
I6I82_RS06185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I82_RS06190	COG4876	unkown
I6I82_RS06195	COG0367	asparagine synthase
I6I82_RS06200	COG0463	Glycosyl transferase, family 2
I6I82_RS06215	COG1309	transcriptional regulator
I6I82_RS06230	COG0398	Pfam SNARE associated Golgi protein
I6I82_RS06235	COG0584	glycerophosphoryl diester phosphodiesterase
I6I82_RS06285	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6I82_RS06305	COG1388	LysM domain
I6I82_RS06305	COG3942	CHAP domain
I6I82_RS06365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I82_RS06370	COG3935	DnaD domain protein
I6I82_RS06375	COG3723	Recombinational DNA repair protein, rece pathway
I6I82_RS06380	COG5377	YqaJ viral recombinase family
I6I82_RS06410	COG1396	sequence-specific DNA binding
I6I82_RS06425	COG4974	Belongs to the 'phage' integrase family
I6I82_RS06430	COG0166	Belongs to the GPI family
I6I82_RS06435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I82_RS06440	COG2081	HI0933 family
I6I82_RS06445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I82_RS06455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I82_RS06460	COG1368	sulfuric ester hydrolase activity
I6I82_RS06475	COG3850	Histidine kinase
I6I82_RS06475	COG5002	protein histidine kinase activity
I6I82_RS06480	COG0745	RESPONSE REGULATOR receiver
I6I82_RS06535	COG0584	glycerophosphoryl diester phosphodiesterase
I6I82_RS06550	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6I82_RS06555	COG0778	Nitroreductase
I6I82_RS06560	COG1846	Transcriptional regulator
I6I82_RS06575	COG1956	GAF domain-containing protein
I6I82_RS06580	COG3527	Alpha-acetolactate decarboxylase
I6I82_RS06585	COG0028	Belongs to the TPP enzyme family
I6I82_RS06590	COG1247	-acetyltransferase
I6I82_RS06600	COG2964	Protein conserved in bacteria
I6I82_RS06610	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I82_RS06615	COG0251	oxidation-reduction process
I6I82_RS06620	COG0626	cystathionine gamma-synthase activity
I6I82_RS06625	COG0789	Transcriptional regulator
I6I82_RS06635	COG1349	DNA-binding transcription factor activity
I6I82_RS06645	COG0745	RESPONSE REGULATOR receiver
I6I82_RS06650	COG2205	protein histidine kinase activity
I6I82_RS06655	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I82_RS06660	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I82_RS06670	COG3684	Belongs to the aldolase LacD family
I6I82_RS06675	COG0698	ribose 5-phosphate isomerase
I6I82_RS06685	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS06700	COG1349	DNA-binding transcription factor activity
I6I82_RS06705	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I82_RS06715	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS06720	COG2188	Transcriptional regulator
I6I82_RS06725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS06730	COG0335	large ribosomal subunit rRNA binding
I6I82_RS06735	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I82_RS06740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I82_RS06750	COG1837	Belongs to the UPF0109 family
I6I82_RS06755	COG0228	four-way junction DNA binding
I6I82_RS06765	COG1131	(ABC) transporter
I6I82_RS06775	COG0431	NADPH-dependent FMN reductase
I6I82_RS06785	COG0519	Catalyzes the synthesis of GMP from XMP
I6I82_RS06790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I82_RS06795	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6I82_RS06800	COG1683	Conserved Protein
I6I82_RS06805	COG0745	RESPONSE REGULATOR receiver
I6I82_RS06810	COG5002	protein histidine kinase activity
I6I82_RS06820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I82_RS06825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I82_RS06855	COG2217	Heavy metal translocating P-type atpase
I6I82_RS06860	COG2217	Heavy metal translocating P-type atpase
I6I82_RS06865	COG2608	mercury ion transmembrane transporter activity
I6I82_RS06870	COG3682	Transcriptional regulator
I6I82_RS06880	COG0531	amino acid
I6I82_RS06885	COG2217	Heavy metal translocating P-type atpase
I6I82_RS06905	COG0017	Asparaginyl-tRNA synthetase
I6I82_RS06910	COG0436	Aminotransferase
I6I82_RS06920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I82_RS06920	COG1199	ATP-dependent helicase activity
I6I82_RS06925	COG1278	Cold shock
I6I82_RS06935	COG1686	Belongs to the peptidase S11 family
I6I82_RS06945	COG0038	chloride channel
I6I82_RS06960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I82_RS06965	COG1254	Belongs to the acylphosphatase family
I6I82_RS06970	COG0706	membrane insertase activity
I6I82_RS06985	COG0438	transferase activity, transferring glycosyl groups
I6I82_RS06990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I82_RS06995	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I82_RS07010	COG4464	protein tyrosine phosphatase activity
I6I82_RS07015	COG0489	protein tyrosine kinase activity
I6I82_RS07025	COG0751	glycine-tRNA ligase activity
I6I82_RS07030	COG0752	glycyl-tRNA synthetase alpha subunit
I6I82_RS07035	COG1381	Involved in DNA repair and RecF pathway recombination
I6I82_RS07040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I82_RS07045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I82_RS07050	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I82_RS07060	COG1702	phosphate starvation-inducible protein PhoH
I6I82_RS07065	COG1610	YqeY-like protein
I6I82_RS07070	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I82_RS07075	COG0735	belongs to the Fur family
I6I82_RS07080	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I82_RS07085	COG0640	Transcriptional regulator
I6I82_RS07090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I82_RS07100	COG0492	ferredoxin-NADP+ reductase activity
I6I82_RS07105	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS07110	COG1486	melibiose metabolic process
I6I82_RS07125	COG1132	(ABC) transporter
I6I82_RS07130	COG1132	(ABC) transporter
I6I82_RS07135	COG3763	UPF0154 protein
I6I82_RS07145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6I82_RS07150	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6I82_RS07150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I82_RS07165	COG1609	Transcriptional regulator
I6I82_RS07175	COG4980	gas vesicle protein
I6I82_RS07185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I82_RS07190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I82_RS07195	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I82_RS07200	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6I82_RS07205	COG1950	PFAM Membrane protein of
I6I82_RS07225	COG0704	Plays a role in the regulation of phosphate uptake
I6I82_RS07230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I82_RS07235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I82_RS07240	COG0581	inorganic phosphate transmembrane transporter activity
I6I82_RS07245	COG0573	inorganic phosphate transmembrane transporter activity
I6I82_RS07250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I82_RS07255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I82_RS07260	COG2177	Part of the ABC transporter FtsEX involved in
I6I82_RS07265	COG2884	Cell division ATP-binding protein ftsE
I6I82_RS07275	COG0653	protein targeting
I6I82_RS07295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS07305	COG1739	Uncharacterized protein family UPF0029
I6I82_RS07310	COG2188	Transcriptional regulator
I6I82_RS07335	COG1940	carbohydrate kinase activity
I6I82_RS07345	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I82_RS07355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I82_RS07385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I82_RS07390	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I82_RS07395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I82_RS07400	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I82_RS07405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I82_RS07410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I82_RS07415	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I82_RS07420	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I82_RS07435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I82_RS07440	COG2388	GCN5-related N-acetyl-transferase
I6I82_RS07460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I82_RS07480	COG3421	Type III restriction
I6I82_RS07485	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6I82_RS07520	COG0582	viral genome integration into host DNA
I6I82_RS07525	COG4974	Belongs to the 'phage' integrase family
I6I82_RS07535	COG0149	triose-phosphate isomerase activity
I6I82_RS07540	COG0126	phosphoglycerate kinase activity
I6I82_RS07555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6I82_RS07575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS07580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS07585	COG1446	asparaginase
I6I82_RS07590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I82_RS07595	COG2188	Transcriptional regulator
I6I82_RS07605	COG1595	DNA-templated transcription, initiation
I6I82_RS07620	COG0095	Lipoate-protein ligase
I6I82_RS07625	COG1078	dGTPase activity
I6I82_RS07630	COG0561	phosphatase activity
I6I82_RS07635	COG0494	nUDIX hydrolase
I6I82_RS07640	COG0346	lactoylglutathione lyase activity
I6I82_RS07645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I82_RS07650	COG1394	ATPase activity, coupled to movement of substances
I6I82_RS07655	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I6I82_RS07660	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I6I82_RS07665	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
I6I82_RS07670	COG1527	subunit (C
I6I82_RS07675	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
I6I82_RS07680	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I82_RS07685	COG1269	ATP hydrolysis coupled proton transport
I6I82_RS07695	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6I82_RS07700	COG1668	transmembrane transport
I6I82_RS07705	COG4152	abc transporter atp-binding protein
I6I82_RS07710	COG0322	excinuclease ABC activity
I6I82_RS07715	COG3118	belongs to the thioredoxin family
I6I82_RS07720	COG1193	negative regulation of DNA recombination
I6I82_RS07735	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I82_RS07755	COG1136	(ABC) transporter
I6I82_RS07765	COG1304	FMN binding
I6I82_RS07775	COG2423	ornithine cyclodeaminase activity
I6I82_RS07780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I82_RS07810	COG0281	malic enzyme
I6I82_RS07835	COG3906	Belongs to the UPF0473 family
I6I82_RS07840	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I82_RS07845	COG4472	Bacterial protein of unknown function (DUF965)
I6I82_RS07870	COG3689	TIGRFAM TIGR03943 family protein
I6I82_RS07875	COG0701	Predicted permease
I6I82_RS07880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I82_RS07895	COG4467	Involved in initiation control of chromosome replication
I6I82_RS07900	COG1774	PSP1 C-terminal conserved region
I6I82_RS07905	COG0470	DNA polymerase III
I6I82_RS07910	COG3870	Protein conserved in bacteria
I6I82_RS07915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I82_RS07920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I82_RS07925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I82_RS07930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I82_RS07950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I82_RS07960	COG2814	Major facilitator Superfamily
I6I82_RS07970	COG1349	DNA-binding transcription factor activity
I6I82_RS07980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS07980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS08000	COG0254	rRNA binding
I6I82_RS08005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I82_RS08010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I82_RS08015	COG0191	fructose-bisphosphate aldolase activity
I6I82_RS08020	COG0504	CTP synthase activity
I6I82_RS08035	COG0174	glutamine synthetase
I6I82_RS08040	COG0789	Transcriptional regulator
I6I82_RS08045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I82_RS08050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I82_RS08055	COG0584	glycerophosphoryl diester phosphodiesterase
I6I82_RS08065	COG0740	serine-type endopeptidase activity
I6I82_RS08070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6I82_RS08080	COG1132	(ABC) transporter
I6I82_RS08090	COG5503	Protein of unknown function (DUF1447)
I6I82_RS08100	COG1278	Cold shock
I6I82_RS08105	COG2003	Belongs to the UPF0758 family
I6I82_RS08195	COG0228	four-way junction DNA binding
I6I82_RS08245	COG1783	phage Terminase large subunit
I6I82_RS08250	COG3728	DNA packaging
I6I82_RS08250	COG5484	DNA packaging
I6I82_RS08295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I82_RS08325	COG1476	TRANSCRIPTIONal
I6I82_RS08330	COG1396	sequence-specific DNA binding
I6I82_RS08380	COG1396	sequence-specific DNA binding
I6I82_RS08390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6I82_RS08395	COG2003	Belongs to the UPF0758 family
I6I82_RS08400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I82_RS08405	COG0285	dihydrofolate synthase activity
I6I82_RS08410	COG0525	valine-tRNA ligase activity
I6I82_RS08420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6I82_RS08425	COG0301	tRNA thio-modification
I6I82_RS08430	COG1104	cysteine desulfurase activity
I6I82_RS08435	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6I82_RS08445	COG0561	phosphatase activity
I6I82_RS08450	COG1801	Protein of unknown function DUF72
I6I82_RS08470	COG3579	cysteine-type endopeptidase activity
I6I82_RS08515	COG1098	S1 RNA binding domain
I6I82_RS08520	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I82_RS08530	COG0492	ferredoxin-NADP+ reductase activity
I6I82_RS08535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6I82_RS08550	COG4470	Protein conserved in bacteria
I6I82_RS08555	COG0737	Belongs to the 5'-nucleotidase family
I6I82_RS08575	COG0590	tRNA wobble adenosine to inosine editing
I6I82_RS08600	COG2738	Putative neutral zinc metallopeptidase
I6I82_RS08605	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I82_RS08610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I82_RS08615	COG4109	DRTGG domain
I6I82_RS08620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6I82_RS08635	COG3237	CsbD-like
I6I82_RS08640	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I82_RS08645	COG1288	antiporter activity
I6I82_RS08650	COG4821	SIS domain
I6I82_RS08660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I82_RS08665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I82_RS08680	COG3397	chitin binding
I6I82_RS08685	COG3397	chitin binding
I6I82_RS08695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I82_RS08700	COG3716	PTS system mannose fructose sorbose family IID component
I6I82_RS08705	COG3715	PTS system
I6I82_RS08715	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS08715	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS08730	COG1132	(ABC) transporter
I6I82_RS08755	COG1803	Methylglyoxal synthase
I6I82_RS08760	COG3842	ATPase activity
I6I82_RS08775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I82_RS08780	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6I82_RS08785	COG0084	hydrolase, TatD family'
I6I82_RS08790	COG0531	amino acid
I6I82_RS08800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I82_RS08805	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I82_RS08805	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I82_RS08815	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I82_RS08815	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I82_RS08840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I82_RS08840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I82_RS08850	COG0675	Transposase, IS605 OrfB family
I6I82_RS08855	COG4608	Belongs to the ABC transporter superfamily
I6I82_RS08860	COG0444	Belongs to the ABC transporter superfamily
I6I82_RS08865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I82_RS08870	COG0601	transmembrane transport
I6I82_RS08880	COG4166	transmembrane transport
I6I82_RS08900	COG1674	ftsk spoiiie
I6I82_RS08900	COG1280	lysine exporter protein (LysE YggA)
I6I82_RS08905	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS08910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I82_RS08915	COG1126	abc transporter atp-binding protein
I6I82_RS08920	COG0765	amino acid transport
I6I82_RS08945	COG2814	Major facilitator Superfamily
I6I82_RS08950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I82_RS08955	COG0482	sulfurtransferase activity
I6I82_RS09005	COG1104	cysteine desulfurase activity
I6I82_RS09010	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I82_RS09020	COG3590	peptidase
I6I82_RS09030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I82_RS09040	COG1335	isochorismatase
I6I82_RS09045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I82_RS09055	COG0494	nUDIX hydrolase
I6I82_RS09065	COG3853	Toxic anion resistance protein (TelA)
I6I82_RS09070	COG0531	amino acid
I6I82_RS09075	COG4975	Glucose uptake
I6I82_RS09080	COG0642	Histidine kinase
I6I82_RS09085	COG0745	RESPONSE REGULATOR receiver
I6I82_RS09095	COG0395	ABC-type sugar transport system, permease component
I6I82_RS09100	COG1175	transmembrane transport
I6I82_RS09110	COG3546	catalase activity
I6I82_RS09115	COG1764	response to oxidative stress
I6I82_RS09130	COG1438	arginine binding
I6I82_RS09140	COG0477	Major facilitator Superfamily
I6I82_RS09145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I82_RS09150	COG1652	LysM domain
I6I82_RS09150	COG2823	Periplasmic or secreted lipoprotein
I6I82_RS09155	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I82_RS09170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I82_RS09175	COG1121	(ABC) transporter
I6I82_RS09180	COG1113	amino acid transport
I6I82_RS09205	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I82_RS09210	COG2207	Transcriptional regulator
I6I82_RS09225	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I82_RS09245	COG4862	establishment of competence for transformation
I6I82_RS09250	COG1393	Belongs to the ArsC family
I6I82_RS09260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I82_RS09265	COG0419	ATPase involved in DNA repair
I6I82_RS09270	COG0420	3'-5' exonuclease activity
I6I82_RS09275	COG0204	Acyl-transferase
I6I82_RS09280	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I82_RS09285	COG2827	Endonuclease containing a URI domain
I6I82_RS09295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I82_RS09295	COG2755	lipolytic protein G-D-S-L family
I6I82_RS09300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I82_RS09305	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I82_RS09310	COG0124	histidyl-tRNA synthetase
I6I82_RS09315	COG0667	Aldo Keto reductase
I6I82_RS09320	COG2124	cytochrome p450
I6I82_RS09325	COG1490	D-aminoacyl-tRNA deacylase activity
I6I82_RS09330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I82_RS09335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I82_RS09340	COG2264	protein methyltransferase activity
I6I82_RS09350	COG2094	Belongs to the DNA glycosylase MPG family
I6I82_RS09360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I82_RS09375	COG0589	response to stress
I6I82_RS09385	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I82_RS09390	COG0827	DNA restriction-modification system
I6I82_RS09415	COG4537	Required for transformation and DNA binding
I6I82_RS09420	COG1459	type II secretion system
I6I82_RS09425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I82_RS09435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I82_RS09445	COG4473	ABC transporter
I6I82_RS09450	COG1131	(ABC) transporter
I6I82_RS09455	COG0537	adenosine 5'-monophosphoramidase activity
I6I82_RS09465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I82_RS09475	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6I82_RS09480	COG4717	serine-type aminopeptidase activity
I6I82_RS09510	COG3679	Belongs to the UPF0342 family
I6I82_RS09515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I82_RS09520	COG0564	pseudouridine synthase activity
I6I82_RS09530	COG0383	alpha-mannosidase activity
I6I82_RS09565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I82_RS09630	COG1764	response to oxidative stress
I6I82_RS09645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I82_RS09655	COG4807	Protein conserved in bacteria
I6I82_RS09720	COG1086	Polysaccharide biosynthesis protein
I6I82_RS09730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I82_RS09735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I82_RS09750	COG4464	protein tyrosine phosphatase activity
I6I82_RS09755	COG0489	protein tyrosine kinase activity
I6I82_RS09760	COG3944	biosynthesis protein
I6I82_RS09765	COG1316	TRANSCRIPTIONal
I6I82_RS09785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS09785	COG1263	PTS System
I6I82_RS09785	COG2190	(PTS) system
I6I82_RS09790	COG2190	(PTS) system
I6I82_RS09790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS09790	COG1263	PTS System
I6I82_RS09795	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6I82_RS09800	COG1737	Transcriptional regulator
I6I82_RS09860	COG3706	GGDEF domain
I6I82_RS09880	COG0463	Glycosyl transferase, family 2
I6I82_RS09895	COG3328	transposase activity
I6I82_RS09905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I82_RS09910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I82_RS09915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I82_RS09920	COG0589	response to stress
I6I82_RS09925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I82_RS09930	COG1363	Peptidase, m42
I6I82_RS09950	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I82_RS09960	COG1215	transferase activity, transferring glycosyl groups
I6I82_RS09970	COG3973	AAA domain
I6I82_RS09975	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I82_RS09980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I82_RS09985	COG1937	Protein conserved in bacteria
I6I82_RS09995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I82_RS10000	COG1193	negative regulation of DNA recombination
I6I82_RS10005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I82_RS10010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I82_RS10015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I82_RS10025	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I82_RS10050	COG1902	pentaerythritol trinitrate reductase activity
I6I82_RS10055	COG1846	Transcriptional regulator
I6I82_RS10075	COG0366	Alpha amylase catalytic
I6I82_RS10080	COG2252	PERMEase
I6I82_RS10095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I82_RS10095	COG0072	phenylalanine-tRNA ligase activity
I6I82_RS10105	COG1846	Transcriptional regulator
I6I82_RS10110	COG1051	belongs to the nudix hydrolase family
I6I82_RS10120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I82_RS10125	COG1113	amino acid transport
I6I82_RS10130	COG1113	amino acid transport
I6I82_RS10160	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6I82_RS10180	COG4716	Myosin-crossreactive antigen
I6I82_RS10190	COG1063	alcohol dehydrogenase
I6I82_RS10205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS10210	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I82_RS10215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS10225	COG0667	Aldo Keto reductase
I6I82_RS10230	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I82_RS10245	COG2207	Transcriptional regulator
I6I82_RS10245	COG4753	response regulator
I6I82_RS10250	COG2972	Histidine kinase
I6I82_RS10260	COG1653	transport
I6I82_RS10265	COG0395	ABC-type sugar transport system, permease component
I6I82_RS10270	COG1175	transmembrane transport
I6I82_RS10315	COG2971	BadF BadG BcrA BcrD
I6I82_RS10320	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I82_RS10325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS10335	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS10340	COG1187	pseudouridine synthase activity
I6I82_RS10345	COG2244	polysaccharide biosynthetic process
I6I82_RS10355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I82_RS10360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS10370	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I82_RS10375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS10375	COG3711	transcriptional antiterminator
I6I82_RS10390	COG0495	leucyl-tRNA aminoacylation
I6I82_RS10395	COG1388	LysM domain
I6I82_RS10395	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6I82_RS10400	COG0671	phosphoesterase, PA-phosphatase related
I6I82_RS10405	COG1242	4 iron, 4 sulfur cluster binding
I6I82_RS10410	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6I82_RS10435	COG1132	(ABC) transporter
I6I82_RS10440	COG1132	(ABC) transporter
I6I82_RS10450	COG1607	acyl-coa hydrolase
I6I82_RS10460	COG0477	Major facilitator Superfamily
I6I82_RS10465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I82_RS10610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I82_RS10615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I82_RS10620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I82_RS10625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I82_RS10630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I82_RS10635	COG0037	tRNA processing
I6I82_RS10640	COG1098	S1 RNA binding domain
I6I82_RS10650	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I82_RS10655	COG2244	polysaccharide biosynthetic process
I6I82_RS10660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I82_RS10665	COG0193	aminoacyl-tRNA hydrolase activity
I6I82_RS10670	COG0039	L-malate dehydrogenase activity
I6I82_RS10705	COG1792	Involved in formation and maintenance of cell shape
I6I82_RS10715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I82_RS10720	COG1162	GTPase activity
I6I82_RS10725	COG2815	serine threonine protein kinase
I6I82_RS10725	COG0515	serine threonine protein kinase
I6I82_RS10730	COG0631	protein serine/threonine phosphatase activity
I6I82_RS10735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I82_RS10735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I82_RS10740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I82_RS10745	COG0242	peptide deformylase activity
I6I82_RS10750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I82_RS10755	COG1758	RNA polymerase activity
I6I82_RS10760	COG0194	GDP metabolic process
I6I82_RS10770	COG1561	YicC-like family, N-terminal region
I6I82_RS10795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I82_RS10800	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I82_RS10805	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I82_RS10810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I82_RS10815	COG1121	(ABC) transporter
I6I82_RS10820	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6I82_RS10820	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I82_RS10825	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I82_RS10830	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6I82_RS10830	COG0392	lysyltransferase activity
I6I82_RS10835	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I82_RS10850	COG1418	mRNA catabolic process
I6I82_RS10855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I82_RS10860	COG1546	Belongs to the CinA family
I6I82_RS10860	COG1058	Belongs to the CinA family
I6I82_RS10865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I82_RS10870	COG1426	Protein conserved in bacteria
I6I82_RS10875	COG0612	Peptidase, M16
I6I82_RS10880	COG0612	Peptidase, M16
I6I82_RS10885	COG1970	mechanosensitive ion channel activity
I6I82_RS10890	COG2153	protein acetylation
I6I82_RS10895	COG4466	Protein conserved in bacteria
I6I82_RS10905	COG3688	RNA-binding protein containing a PIN domain
I6I82_RS10915	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6I82_RS10920	COG0215	cysteine-tRNA ligase activity
I6I82_RS10925	COG1045	serine acetyltransferase
I6I82_RS10930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I82_RS10935	COG4956	integral membrane protein (PIN domain superfamily)
I6I82_RS10945	COG0756	dUTP diphosphatase activity
I6I82_RS10950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I82_RS10955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I82_RS10970	COG2814	Major facilitator Superfamily
I6I82_RS10985	COG0702	epimerase
I6I82_RS10990	COG1959	2 iron, 2 sulfur cluster binding
I6I82_RS11000	COG1674	ftsk spoiiie
I6I82_RS11015	COG4842	Belongs to the WXG100 family
I6I82_RS11020	COG1562	ergosterol biosynthetic process
I6I82_RS11025	COG1233	COG1233 Phytoene dehydrogenase and related
I6I82_RS11030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I82_RS11040	COG0842	Transport permease protein
I6I82_RS11045	COG1131	(ABC) transporter
I6I82_RS11050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I82_RS11060	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS11075	COG4585	Histidine kinase
I6I82_RS11080	COG2197	response regulator
I6I82_RS11100	COG3414	Phosphotransferase system galactitol-specific IIB component
I6I82_RS11105	COG3775	system Galactitol-specific IIC component
I6I82_RS11110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS11115	COG3711	transcriptional antiterminator
I6I82_RS11115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS11185	COG0582	viral genome integration into host DNA
I6I82_RS11190	COG0582	viral genome integration into host DNA
I6I82_RS11195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I82_RS11200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I82_RS11205	COG0783	Belongs to the Dps family
I6I82_RS11210	COG1070	Carbohydrate kinase
I6I82_RS11215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6I82_RS11220	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I82_RS11230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I82_RS11250	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6I82_RS11260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I82_RS11260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I82_RS11270	COG0142	geranyltranstransferase activity
I6I82_RS11290	COG4939	FMN-binding domain protein
I6I82_RS11325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I82_RS11330	COG0826	peptidase U32
I6I82_RS11335	COG0826	peptidase U32
I6I82_RS11340	COG0542	response to heat
I6I82_RS11345	COG4463	regulation of RNA biosynthetic process
I6I82_RS11420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I82_RS11425	COG0517	IMP dehydrogenase activity
I6I82_RS11425	COG0516	GMP reductase activity
I6I82_RS11435	COG0012	GTP binding
I6I82_RS11440	COG4481	Protein conserved in bacteria
I6I82_RS11445	COG1475	DNA binding
I6I82_RS11450	COG1192	Involved in chromosome partitioning
I6I82_RS11455	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I82_RS11465	COG0445	tRNA wobble uridine modification
I6I82_RS11470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I82_RS11480	COG1847	R3H domain protein
I6I82_RS11485	COG0706	membrane insertase activity
I6I82_RS11490	COG0594	ribonuclease P activity
I6I82_RS11495	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I82_RS11500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I82_RS11505	COG0592	DNA-directed DNA polymerase activity
I6I82_RS11510	COG2501	S4 domain
I6I82_RS11515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I82_RS11520	COG0187	DNA topoisomerase II activity
I6I82_RS11530	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I82_RS11535	COG0629	single-stranded DNA binding
I6I82_RS11540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I82_RS11555	COG0359	binds to the 23S rRNA
I6I82_RS11565	COG0305	Participates in initiation and elongation during chromosome replication
I6I82_RS11570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I82_RS11585	COG0488	(ABC) transporter
I6I82_RS11595	COG0028	Belongs to the TPP enzyme family
I6I82_RS11630	COG0519	Catalyzes the synthesis of GMP from XMP
I6I82_RS11630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I82_RS11635	COG1072	(Pantothenic acid kinase))
I6I82_RS11640	COG2813	Specifically methylates the guanine in position
I6I82_RS11650	COG1609	Transcriptional regulator
I6I82_RS11655	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I82_RS11660	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I82_RS11665	COG0295	cytidine deaminase activity
I6I82_RS11670	COG1744	ABC transporter substrate-binding protein PnrA-like
I6I82_RS11675	COG3845	ABC transporter
I6I82_RS11680	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I82_RS11685	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I82_RS11690	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I82_RS11700	COG0813	purine-nucleoside phosphorylase activity
I6I82_RS11705	COG0588	phosphoglycerate mutase activity
I6I82_RS11715	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I82_RS11720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I82_RS11725	COG0049	tRNA binding
I6I82_RS11730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I82_RS11735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I82_RS11740	COG3711	transcriptional antiterminator
I6I82_RS11745	COG1263	PTS System
I6I82_RS11745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS11745	COG2190	(PTS) system
I6I82_RS11755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS11755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS11755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS11760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS11765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS11765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS11780	COG0051	transcription antitermination factor activity, RNA binding
I6I82_RS11785	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I82_RS11790	COG0088	Forms part of the polypeptide exit tunnel
I6I82_RS11795	COG0089	rRNA binding
I6I82_RS11800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I82_RS11810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I82_RS11815	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I82_RS11820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I82_RS11825	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I82_RS11830	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I82_RS11835	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I82_RS11840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I82_RS11845	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I82_RS11850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I82_RS11855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I82_RS11860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I82_RS11865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I82_RS11870	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I82_RS11875	COG1841	ribosomal large subunit assembly
I6I82_RS11880	COG0200	Binds to the 23S rRNA
I6I82_RS11885	COG0201	protein transport
I6I82_RS11890	COG0563	adenylate kinase activity
I6I82_RS11895	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I82_RS11900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I82_RS11905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I82_RS11910	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I82_RS11915	COG0202	RNA polymerase activity
I6I82_RS11920	COG0203	ribosomal protein L17
I6I82_RS11925	COG1122	ATPase activity
I6I82_RS11930	COG1122	ATPase activity
I6I82_RS11955	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I82_RS11965	COG1461	Dihydroxyacetone kinase
I6I82_RS11970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I82_RS11975	COG0416	fatty acid biosynthetic process
I6I82_RS11980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I82_RS11995	COG4608	Belongs to the ABC transporter superfamily
I6I82_RS12000	COG0601	transmembrane transport
I6I82_RS12015	COG0571	ribonuclease III activity
I6I82_RS12020	COG1196	nuclear chromosome segregation
I6I82_RS12025	COG0561	phosphatase activity
I6I82_RS12030	COG0552	protein localization to endoplasmic reticulum
I6I82_RS12035	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I82_RS12035	COG2918	glutathione biosynthetic process
I6I82_RS12065	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I82_RS12070	COG4605	iron ion homeostasis
I6I82_RS12075	COG4604	ABC transporter, ATP-binding protein
I6I82_RS12080	COG4607	ABC-type enterochelin transport system periplasmic component
I6I82_RS12095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I82_RS12120	COG1380	Effector of murein hydrolase LrgA
I6I82_RS12125	COG1346	cytolysis
I6I82_RS12140	COG1028	Short-chain dehydrogenase reductase Sdr
I6I82_RS12145	COG4708	membrane
I6I82_RS12155	COG1268	BioY protein
I6I82_RS12160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I82_RS12170	COG0561	phosphatase activity
I6I82_RS12175	COG1692	metallophosphoesterase
I6I82_RS12185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I82_RS12215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS12215	COG1263	PTS System
I6I82_RS12220	COG2188	Transcriptional regulator
I6I82_RS12230	COG0632	four-way junction helicase activity
I6I82_RS12235	COG2255	four-way junction helicase activity
I6I82_RS12245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I82_RS12260	COG1114	Component of the transport system for branched-chain amino acids
I6I82_RS12265	COG1113	amino acid transport
I6I82_RS12270	COG1126	abc transporter atp-binding protein
I6I82_RS12275	COG0765	amino acid transport
I6I82_RS12285	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I82_RS12290	COG0110	maltose O-acetyltransferase activity
I6I82_RS12295	COG1827	regulation of RNA biosynthetic process
I6I82_RS12305	COG0242	peptide deformylase activity
I6I82_RS12310	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I82_RS12315	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I82_RS12325	COG3158	transport of potassium into the cell
I6I82_RS12335	COG1253	flavin adenine dinucleotide binding
I6I82_RS12345	COG0534	Mate efflux family protein
I6I82_RS12355	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I82_RS12360	COG1187	pseudouridine synthase activity
I6I82_RS12365	COG1011	Hydrolase
I6I82_RS12370	COG0572	uridine kinase
I6I82_RS12390	COG1671	Belongs to the UPF0178 family
I6I82_RS12400	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I82_RS12405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I82_RS12415	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I82_RS12420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I82_RS12425	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6I82_RS12430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I82_RS12435	COG1064	alcohol dehydrogenase
I6I82_RS12445	COG0531	amino acid
I6I82_RS12455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I82_RS12485	COG1764	response to oxidative stress
I6I82_RS12505	COG0343	queuine tRNA-ribosyltransferase activity
I6I82_RS12510	COG1862	Preprotein translocase
I6I82_RS12515	COG1454	alcohol dehydrogenase
I6I82_RS12515	COG1012	belongs to the aldehyde dehydrogenase family
I6I82_RS12525	COG1304	FMN binding
I6I82_RS12540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I82_RS12545	COG1428	Deoxynucleoside kinase
I6I82_RS12555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I82_RS12560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I82_RS12565	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I82_RS12585	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I82_RS12605	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6I82_RS12610	COG2376	Dihydroxyacetone kinase
I6I82_RS12615	COG1461	Dihydroxyacetone kinase
I6I82_RS12645	COG0531	amino acid
I6I82_RS12650	COG1757	Na H antiporter
I6I82_RS12655	COG1609	Transcriptional regulator
I6I82_RS12665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I82_RS12675	COG1263	PTS System
I6I82_RS12675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS12675	COG2190	(PTS) system
I6I82_RS12695	COG3479	Phenolic acid decarboxylase
I6I82_RS12700	COG1695	Transcriptional regulator
I6I82_RS12710	COG2814	Major facilitator Superfamily
I6I82_RS12735	COG1136	(ABC) transporter
I6I82_RS12735	COG0577	efflux transmembrane transporter activity
I6I82_RS12745	COG3850	Histidine kinase
I6I82_RS12745	COG5002	protein histidine kinase activity
I6I82_RS12780	COG1136	(ABC) transporter
I6I82_RS12790	COG3942	CHAP domain
I6I82_RS12790	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6I82_RS12795	COG1609	Transcriptional regulator
I6I82_RS12815	COG0366	Alpha amylase catalytic
I6I82_RS12840	COG0628	permease
I6I82_RS12845	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6I82_RS12845	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I82_RS12850	COG3279	Response regulator of the LytR AlgR family
I6I82_RS12875	COG0210	DNA helicase
I6I82_RS12880	COG1393	Belongs to the ArsC family
I6I82_RS12885	COG1393	Belongs to the ArsC family
I6I82_RS12910	COG0386	Belongs to the glutathione peroxidase family
I6I82_RS12920	COG0626	cystathionine gamma-synthase activity
I6I82_RS12925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I82_RS12930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I82_RS12960	COG1272	protein, Hemolysin III
I6I82_RS12965	COG0019	diaminopimelate decarboxylase activity
I6I82_RS12970	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I82_RS12980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I82_RS12985	COG2171	N-acyltransferase activity
I6I82_RS12990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I82_RS12995	COG0527	aspartate kinase activity
I6I82_RS13000	COG1473	amidohydrolase
I6I82_RS13005	COG0436	Aminotransferase
I6I82_RS13020	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I82_RS13025	COG2207	Transcriptional regulator
I6I82_RS13025	COG0662	Cupin 2, conserved barrel domain protein
I6I82_RS13035	COG2211	Major facilitator Superfamily
I6I82_RS13065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I82_RS13080	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6I82_RS13085	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I82_RS13090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I82_RS13095	COG0287	Prephenate dehydrogenase
I6I82_RS13105	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I82_RS13110	COG0077	Prephenate dehydratase
I6I82_RS13115	COG0693	protein deglycase activity
I6I82_RS13125	COG4116	CYTH
I6I82_RS13130	COG2357	RelA SpoT domain protein
I6I82_RS13135	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I82_RS13140	COG0564	pseudouridine synthase activity
I6I82_RS13145	COG2239	Acts as a magnesium transporter
I6I82_RS13150	COG3142	Participates in the control of copper homeostasis
I6I82_RS13160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I82_RS13165	COG0406	alpha-ribazole phosphatase activity
I6I82_RS13170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I82_RS13175	COG1597	lipid kinase activity
I6I82_RS13190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I82_RS13200	COG0250	Participates in transcription elongation, termination and antitermination
I6I82_RS13210	COG1760	l-serine dehydratase
I6I82_RS13215	COG1760	l-serine dehydratase
I6I82_RS13220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I82_RS13225	COG0081	regulation of translation
I6I82_RS13230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I82_RS13235	COG0222	ribosome binding
I6I82_RS13295	COG5377	YqaJ viral recombinase family
I6I82_RS13300	COG3723	Recombinational DNA repair protein, rece pathway
I6I82_RS13305	COG3935	DnaD domain protein
I6I82_RS13310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I82_RS13385	COG1783	phage Terminase large subunit
I6I82_RS13460	COG0739	heme binding
I6I82_RS13460	COG0741	lytic transglycosylase activity
I6I82_RS13460	COG1196	nuclear chromosome segregation
I6I82_RS13510	COG3942	CHAP domain
I6I82_RS13510	COG1388	LysM domain
I6I82_RS13545	COG2814	Major facilitator Superfamily
I6I82_RS13560	COG0488	(ABC) transporter
I6I82_RS13565	COG0363	glucosamine-6-phosphate deaminase activity
I6I82_RS13570	COG1285	pathogenesis
I6I82_RS13575	COG0628	permease
I6I82_RS13580	COG3711	transcriptional antiterminator
I6I82_RS13580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS13590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS13595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS13600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I82_RS13610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I82_RS13630	COG1070	Carbohydrate kinase
I6I82_RS13645	COG3715	PTS system
I6I82_RS13665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I82_RS13670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I82_RS13695	COG4175	Glycine betaine
I6I82_RS13695	COG3448	diguanylate cyclase activity
I6I82_RS13705	COG2135	peptidase activity
I6I82_RS13725	COG1307	EDD domain protein, DegV family
I6I82_RS13735	COG0745	RESPONSE REGULATOR receiver
I6I82_RS13740	COG5002	protein histidine kinase activity
I6I82_RS13755	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I82_RS13775	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I82_RS13780	COG0459	protein refolding
I6I82_RS13790	COG1609	Transcriptional regulator
I6I82_RS13795	COG0789	Transcriptional regulator
I6I82_RS13810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I82_RS13815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I82_RS13820	COG1368	sulfuric ester hydrolase activity
I6I82_RS13835	COG2706	6-phosphogluconolactonase activity
I6I82_RS13845	COG0628	permease
I6I82_RS13850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I82_RS13880	COG1482	cell wall glycoprotein biosynthetic process
I6I82_RS13890	COG1869	D-ribose catabolic process
I6I82_RS13895	COG4975	Glucose uptake
I6I82_RS13955	COG3442	glutamine amidotransferase
I6I82_RS13960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I82_RS13965	COG1396	sequence-specific DNA binding
I6I82_RS13975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I82_RS13995	COG0681	Belongs to the peptidase S26 family
I6I82_RS14005	COG1435	thymidine kinase activity
I6I82_RS14010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I82_RS14015	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I82_RS14020	COG0009	L-threonylcarbamoyladenylate synthase
I6I82_RS14025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I82_RS14030	COG0657	acetylesterase activity
I6I82_RS14035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I82_RS14060	COG0463	Glycosyl transferase, family 2
I6I82_RS14065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I82_RS14070	COG2855	membrane
I6I82_RS14080	COG0583	DNA-binding transcription factor activity
I6I82_RS14085	COG0772	Belongs to the SEDS family
I6I82_RS14090	COG1393	Belongs to the ArsC family
I6I82_RS14095	COG0509	glycine decarboxylation via glycine cleavage system
I6I82_RS14100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I82_RS14105	COG2011	ABC-type metal ion transport system permease component
I6I82_RS14110	COG1464	Belongs to the NlpA lipoprotein family
I6I82_RS14120	COG0719	Fe-S assembly protein
I6I82_RS14125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I82_RS14135	COG0719	Fe-S assembly protein
I6I82_RS14180	COG2188	Transcriptional regulator
I6I82_RS14185	COG2222	sugar isomerase
I6I82_RS14190	COG3684	Belongs to the aldolase LacD family
I6I82_RS14195	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I82_RS14210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I82_RS14210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS14215	COG3715	PTS system
I6I82_RS14220	COG3716	PTS system mannose fructose sorbose family IID component
I6I82_RS14230	COG2197	response regulator
I6I82_RS14240	COG0531	amino acid
I6I82_RS14245	COG2957	Belongs to the agmatine deiminase family
I6I82_RS14255	COG1136	(ABC) transporter
I6I82_RS14275	COG1597	lipid kinase activity
I6I82_RS14280	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6I82_RS14285	COG2814	Major facilitator Superfamily
I6I82_RS14295	COG3764	Sortase (surface protein transpeptidase)
I6I82_RS14300	COG3711	transcriptional antiterminator
I6I82_RS14305	COG1263	PTS System
I6I82_RS14305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I82_RS14305	COG2190	(PTS) system
I6I82_RS14310	COG2723	6-phospho-beta-galactosidase activity
I6I82_RS14315	COG2116	formate transmembrane transporter activity
I6I82_RS14320	COG2188	Transcriptional regulator
I6I82_RS14325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I82_RS14385	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6I82_RS14385	COG1388	LysM domain
I6I82_RS14480	COG1192	Involved in chromosome partitioning
I6I82_RS14500	COG3583	domain protein
I6I82_RS14590	COG0629	single-stranded DNA binding