locus-tag	class	description
HZ311_RS00015	COG0039	L-malate dehydrogenase activity
HZ311_RS00040	COG1874	Beta-galactosidase
HZ311_RS00055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS00060	COG1609	Transcriptional regulator
HZ311_RS00065	COG0673	inositol 2-dehydrogenase activity
HZ311_RS00070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HZ311_RS00075	COG0406	alpha-ribazole phosphatase activity
HZ311_RS00110	COG0745	RESPONSE REGULATOR receiver
HZ311_RS00115	COG5002	protein histidine kinase activity
HZ311_RS00120	COG4974	Belongs to the 'phage' integrase family
HZ311_RS00130	COG0351	phosphomethylpyrimidine kinase
HZ311_RS00135	COG4720	Psort location CytoplasmicMembrane, score
HZ311_RS00140	COG4475	Protein of unknown function (DUF436)
HZ311_RS00145	COG0366	Alpha amylase catalytic
HZ311_RS00160	COG1307	EDD domain protein, DegV family
HZ311_RS00165	COG2244	polysaccharide biosynthetic process
HZ311_RS00210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZ311_RS00240	COG0167	dihydroorotate dehydrogenase activity
HZ311_RS00250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZ311_RS00260	COG3833	ABC-type maltose transport systems, permease component
HZ311_RS00265	COG1175	transmembrane transport
HZ311_RS00270	COG2182	Extracellular solute-binding protein
HZ311_RS00275	COG0366	Alpha amylase catalytic
HZ311_RS00280	COG4948	Mandelate Racemase Muconate Lactonizing
HZ311_RS00290	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HZ311_RS00295	COG1169	isochorismate synthase
HZ311_RS00300	COG0318	PFAM AMP-dependent synthetase and ligase
HZ311_RS00305	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HZ311_RS00360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ311_RS00365	COG1764	response to oxidative stress
HZ311_RS00370	COG1846	Transcriptional regulator
HZ311_RS00375	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HZ311_RS00410	COG0768	penicillin binding
HZ311_RS00420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZ311_RS00435	COG0737	Belongs to the 5'-nucleotidase family
HZ311_RS00440	COG1653	transport
HZ311_RS00455	COG1175	transmembrane transport
HZ311_RS00460	COG3842	ATPase activity
HZ311_RS00470	COG2261	transglycosylase associated protein
HZ311_RS00495	COG4512	PFAM Accessory gene regulator B
HZ311_RS00515	COG3655	Transcriptional regulator
HZ311_RS00545	COG2261	transglycosylase associated protein
HZ311_RS00565	COG1028	Short-chain dehydrogenase reductase Sdr
HZ311_RS00580	COG1442	glycosyl transferase family 8
HZ311_RS00585	COG1442	glycosyl transferase family 8
HZ311_RS00590	COG0561	phosphatase activity
HZ311_RS00600	COG1476	TRANSCRIPTIONal
HZ311_RS00610	COG1278	Cold shock
HZ311_RS00615	COG0655	NAD(P)H dehydrogenase (quinone) activity
HZ311_RS00635	COG0789	Transcriptional regulator
HZ311_RS00650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZ311_RS00655	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZ311_RS00670	COG1136	(ABC) transporter
HZ311_RS00680	COG0481	GTPase activity
HZ311_RS00700	COG4975	Glucose uptake
HZ311_RS00705	COG0383	alpha-mannosidase activity
HZ311_RS00710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS00715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS00720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS00725	COG3711	transcriptional antiterminator
HZ311_RS00725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS00730	COG0542	response to heat
HZ311_RS00740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS00745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS00750	COG1446	asparaginase
HZ311_RS00755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZ311_RS00760	COG2188	Transcriptional regulator
HZ311_RS00775	COG1597	lipid kinase activity
HZ311_RS00780	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZ311_RS00785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HZ311_RS00790	COG2384	SAM-dependent methyltransferase
HZ311_RS00800	COG1484	DNA-dependent DNA replication
HZ311_RS00810	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZ311_RS00820	COG0237	dephospho-CoA kinase activity
HZ311_RS00825	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HZ311_RS00830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ311_RS00830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ311_RS00845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZ311_RS00850	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HZ311_RS00855	COG3091	SprT-like family
HZ311_RS00860	COG2183	response to ionizing radiation
HZ311_RS00865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZ311_RS00925	COG1823	symporter activity
HZ311_RS00990	COG2207	Transcriptional regulator
HZ311_RS00990	COG4753	response regulator
HZ311_RS00995	COG2972	Histidine kinase
HZ311_RS01000	COG3250	beta-galactosidase activity
HZ311_RS01015	COG1609	Transcriptional regulator
HZ311_RS01020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HZ311_RS01035	COG1132	(ABC) transporter
HZ311_RS01060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZ311_RS01065	COG1597	lipid kinase activity
HZ311_RS01070	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZ311_RS01075	COG0154	amidase activity
HZ311_RS01080	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZ311_RS01085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZ311_RS01090	COG0210	DNA helicase
HZ311_RS01095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS01095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS01095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS01100	COG1105	Belongs to the carbohydrate kinase PfkB family
HZ311_RS01105	COG1349	DNA-binding transcription factor activity
HZ311_RS01120	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZ311_RS01125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZ311_RS01130	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZ311_RS01140	COG1714	RDD family
HZ311_RS01155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZ311_RS01230	COG1481	regulation of sporulation
HZ311_RS01235	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HZ311_RS01240	COG1660	Displays ATPase and GTPase activities
HZ311_RS01245	COG1794	racemase activity, acting on amino acids and derivatives
HZ311_RS01255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZ311_RS01260	COG0556	nucleotide-excision repair
HZ311_RS01265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ311_RS01280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS01280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS01285	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZ311_RS01290	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS01295	COG1349	DNA-binding transcription factor activity
HZ311_RS01300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZ311_RS01305	COG0484	heat shock protein binding
HZ311_RS01310	COG0443	Heat shock 70 kDa protein
HZ311_RS01315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZ311_RS01320	COG1420	regulation of RNA biosynthetic process
HZ311_RS01325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZ311_RS01330	COG0582	viral genome integration into host DNA
HZ311_RS01355	COG0433	COG0433 Predicted ATPase
HZ311_RS01410	COG2946	Replication initiation factor
HZ311_RS01470	COG1396	sequence-specific DNA binding
HZ311_RS01505	COG2801	Transposase and inactivated derivatives
HZ311_RS01510	COG2801	Transposase and inactivated derivatives
HZ311_RS01535	COG4658	electron transport chain
HZ311_RS01540	COG4656	Part of a membrane complex involved in electron transport
HZ311_RS01545	COG0205	6-phosphofructokinase activity
HZ311_RS01560	COG4975	Glucose uptake
HZ311_RS01570	COG0196	riboflavin kinase activity
HZ311_RS01575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZ311_RS01580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZ311_RS01595	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HZ311_RS01600	COG0195	Participates in both transcription termination and antitermination
HZ311_RS01605	COG0779	Required for maturation of 30S ribosomal subunits
HZ311_RS01610	COG2176	DNA-directed DNA polymerase activity
HZ311_RS01615	COG0442	prolyl-tRNA aminoacylation
HZ311_RS01620	COG0750	zinc metalloprotease
HZ311_RS01625	COG4589	Belongs to the CDS family
HZ311_RS01630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZ311_RS01635	COG0233	cytoplasmic translational termination
HZ311_RS01640	COG0528	UMP kinase activity
HZ311_RS01645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZ311_RS01650	COG0052	Belongs to the universal ribosomal protein uS2 family
HZ311_RS01655	COG1438	arginine binding
HZ311_RS01690	COG0018	arginyl-trna synthetase
HZ311_RS01700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZ311_RS01705	COG2235	arginine
HZ311_RS01720	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HZ311_RS01725	COG1215	transferase activity, transferring glycosyl groups
HZ311_RS01735	COG0438	transferase activity, transferring glycosyl groups
HZ311_RS01740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZ311_RS01745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZ311_RS01765	COG0489	protein tyrosine kinase activity
HZ311_RS01770	COG3944	biosynthesis protein
HZ311_RS01790	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZ311_RS01805	COG1214	PFAM Peptidase M22, glycoprotease
HZ311_RS01810	COG1609	Transcriptional regulator
HZ311_RS01815	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HZ311_RS01820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZ311_RS01835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ311_RS01840	COG1940	carbohydrate kinase activity
HZ311_RS01855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZ311_RS01880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ311_RS01885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ311_RS01890	COG1120	ATPase activity
HZ311_RS01900	COG0745	RESPONSE REGULATOR receiver
HZ311_RS01905	COG2205	protein histidine kinase activity
HZ311_RS01910	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HZ311_RS01915	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HZ311_RS01920	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HZ311_RS01930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZ311_RS01935	COG4876	unkown
HZ311_RS01940	COG0367	asparagine synthase
HZ311_RS01955	COG1309	transcriptional regulator
HZ311_RS01970	COG0398	Pfam SNARE associated Golgi protein
HZ311_RS01975	COG0584	glycerophosphoryl diester phosphodiesterase
HZ311_RS01990	COG1396	sequence-specific DNA binding
HZ311_RS02005	COG1278	Cold shock
HZ311_RS02020	COG1278	Cold shock
HZ311_RS02030	COG0166	Belongs to the GPI family
HZ311_RS02035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZ311_RS02040	COG2081	HI0933 family
HZ311_RS02045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZ311_RS02050	COG0710	3-dehydroquinate dehydratase activity
HZ311_RS02055	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZ311_RS02060	COG1368	sulfuric ester hydrolase activity
HZ311_RS02075	COG5002	protein histidine kinase activity
HZ311_RS02075	COG3850	Histidine kinase
HZ311_RS02080	COG0745	RESPONSE REGULATOR receiver
HZ311_RS02115	COG3052	prosthetic group binding
HZ311_RS02120	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HZ311_RS02130	COG0511	ligase activity, forming carbon-carbon bonds
HZ311_RS02140	COG2851	Citrate transporter
HZ311_RS02145	COG2188	Transcriptional regulator
HZ311_RS02150	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HZ311_RS02155	COG0745	RESPONSE REGULATOR receiver
HZ311_RS02165	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HZ311_RS02170	COG0778	Nitroreductase
HZ311_RS02175	COG1846	Transcriptional regulator
HZ311_RS02185	COG1956	GAF domain-containing protein
HZ311_RS02190	COG3527	Alpha-acetolactate decarboxylase
HZ311_RS02230	COG0028	Belongs to the TPP enzyme family
HZ311_RS02235	COG1247	-acetyltransferase
HZ311_RS02245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZ311_RS02250	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HZ311_RS02250	COG3064	Membrane
HZ311_RS02250	COG3583	domain protein
HZ311_RS02260	COG1349	DNA-binding transcription factor activity
HZ311_RS02265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZ311_RS02285	COG4149	molybdate abc transporter
HZ311_RS02295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZ311_RS02365	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HZ311_RS02370	COG2160	L-arabinose isomerase activity
HZ311_RS02385	COG1609	Transcriptional regulator
HZ311_RS02395	COG4214	carbohydrate transport
HZ311_RS02405	COG4213	ABC transporter substrate-binding protein
HZ311_RS02410	COG1879	ABC-type sugar transport system periplasmic component
HZ311_RS02415	COG2972	Histidine kinase
HZ311_RS02420	COG4753	response regulator
HZ311_RS02420	COG2207	Transcriptional regulator
HZ311_RS02460	COG3732	PTS system glucitol sorbitol-specific
HZ311_RS02465	COG3730	PTS system glucitol sorbitol-specific
HZ311_RS02495	COG0351	phosphomethylpyrimidine kinase
HZ311_RS02495	COG0352	thiamine-phosphate diphosphorylase activity
HZ311_RS02500	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HZ311_RS02510	COG0335	large ribosomal subunit rRNA binding
HZ311_RS02515	COG0336	Belongs to the RNA methyltransferase TrmD family
HZ311_RS02520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZ311_RS02530	COG1837	Belongs to the UPF0109 family
HZ311_RS02535	COG0228	four-way junction DNA binding
HZ311_RS02540	COG0431	NADPH-dependent FMN reductase
HZ311_RS02545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZ311_RS02550	COG0519	Catalyzes the synthesis of GMP from XMP
HZ311_RS02555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZ311_RS02560	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HZ311_RS02565	COG1683	Conserved Protein
HZ311_RS02570	COG0745	RESPONSE REGULATOR receiver
HZ311_RS02575	COG5002	protein histidine kinase activity
HZ311_RS02580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZ311_RS02585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZ311_RS02610	COG2217	Heavy metal translocating P-type atpase
HZ311_RS02615	COG2217	Heavy metal translocating P-type atpase
HZ311_RS02620	COG2608	mercury ion transmembrane transporter activity
HZ311_RS02625	COG3682	Transcriptional regulator
HZ311_RS02635	COG0531	amino acid
HZ311_RS02640	COG2217	Heavy metal translocating P-type atpase
HZ311_RS02670	COG0017	Asparaginyl-tRNA synthetase
HZ311_RS02675	COG0436	Aminotransferase
HZ311_RS02685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZ311_RS02685	COG1199	ATP-dependent helicase activity
HZ311_RS02690	COG1278	Cold shock
HZ311_RS02700	COG1686	Belongs to the peptidase S11 family
HZ311_RS02710	COG0038	chloride channel
HZ311_RS02725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZ311_RS02730	COG1254	Belongs to the acylphosphatase family
HZ311_RS02735	COG0706	membrane insertase activity
HZ311_RS02740	COG0751	glycine-tRNA ligase activity
HZ311_RS02745	COG0752	glycyl-tRNA synthetase alpha subunit
HZ311_RS02750	COG1381	Involved in DNA repair and RecF pathway recombination
HZ311_RS02755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZ311_RS02760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HZ311_RS02765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HZ311_RS02775	COG1702	phosphate starvation-inducible protein PhoH
HZ311_RS02780	COG1610	YqeY-like protein
HZ311_RS02785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HZ311_RS02790	COG0735	belongs to the Fur family
HZ311_RS02795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HZ311_RS02800	COG0640	Transcriptional regulator
HZ311_RS02805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZ311_RS02810	COG0492	ferredoxin-NADP+ reductase activity
HZ311_RS02815	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS02820	COG1486	melibiose metabolic process
HZ311_RS02825	COG1737	Transcriptional regulator
HZ311_RS02830	COG2190	(PTS) system
HZ311_RS02830	COG1263	PTS System
HZ311_RS02830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS02835	COG3711	transcriptional antiterminator
HZ311_RS02840	COG1132	(ABC) transporter
HZ311_RS02845	COG1132	(ABC) transporter
HZ311_RS02850	COG3763	UPF0154 protein
HZ311_RS02855	COG1914	H( )-stimulated, divalent metal cation uptake system
HZ311_RS02865	COG0656	L-ascorbic acid biosynthetic process
HZ311_RS02870	COG0789	Transcriptional regulator
HZ311_RS02880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HZ311_RS02890	COG1609	Transcriptional regulator
HZ311_RS02895	COG0006	proline dipeptidase activity
HZ311_RS02905	COG4980	gas vesicle protein
HZ311_RS02915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZ311_RS02920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZ311_RS02925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZ311_RS02930	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HZ311_RS02960	COG0704	Plays a role in the regulation of phosphate uptake
HZ311_RS02965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZ311_RS02970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZ311_RS02975	COG0581	inorganic phosphate transmembrane transporter activity
HZ311_RS02980	COG0573	inorganic phosphate transmembrane transporter activity
HZ311_RS02985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZ311_RS02990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ311_RS02995	COG2177	Part of the ABC transporter FtsEX involved in
HZ311_RS03000	COG2884	Cell division ATP-binding protein ftsE
HZ311_RS03010	COG0653	protein targeting
HZ311_RS03020	COG1040	competence protein
HZ311_RS03025	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HZ311_RS03035	COG1739	Uncharacterized protein family UPF0029
HZ311_RS03040	COG2188	Transcriptional regulator
HZ311_RS03075	COG1940	carbohydrate kinase activity
HZ311_RS03080	COG0456	acetyltransferase
HZ311_RS03095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZ311_RS03110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZ311_RS03115	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZ311_RS03125	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZ311_RS03130	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZ311_RS03135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZ311_RS03140	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZ311_RS03145	COG0356	it plays a direct role in the translocation of protons across the membrane
HZ311_RS03150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZ311_RS03155	COG0557	exoribonuclease II activity
HZ311_RS03165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZ311_RS03170	COG2388	GCN5-related N-acetyl-transferase
HZ311_RS03190	COG0110	maltose O-acetyltransferase activity
HZ311_RS03250	COG0149	triose-phosphate isomerase activity
HZ311_RS03255	COG0126	phosphoglycerate kinase activity
HZ311_RS03270	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HZ311_RS03300	COG0095	Lipoate-protein ligase
HZ311_RS03305	COG1078	dGTPase activity
HZ311_RS03310	COG0561	phosphatase activity
HZ311_RS03315	COG0494	nUDIX hydrolase
HZ311_RS03320	COG0346	lactoylglutathione lyase activity
HZ311_RS03325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZ311_RS03330	COG1394	ATPase activity, coupled to movement of substances
HZ311_RS03335	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HZ311_RS03340	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HZ311_RS03345	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HZ311_RS03350	COG1527	subunit (C
HZ311_RS03355	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
HZ311_RS03360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZ311_RS03365	COG1269	ATP hydrolysis coupled proton transport
HZ311_RS03380	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HZ311_RS03390	COG4152	abc transporter atp-binding protein
HZ311_RS03395	COG0322	excinuclease ABC activity
HZ311_RS03400	COG3118	belongs to the thioredoxin family
HZ311_RS03405	COG1193	negative regulation of DNA recombination
HZ311_RS03420	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZ311_RS03425	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ311_RS03425	COG4991	sh3 domain protein
HZ311_RS03425	COG3103	Sh3 type 3 domain protein
HZ311_RS03440	COG1309	transcriptional regulator
HZ311_RS03445	COG1136	(ABC) transporter
HZ311_RS03455	COG3623	hexulose-6-phosphate isomerase
HZ311_RS03490	COG1304	FMN binding
HZ311_RS03500	COG2423	ornithine cyclodeaminase activity
HZ311_RS03505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ311_RS03510	COG0281	malic enzyme
HZ311_RS03530	COG3906	Belongs to the UPF0473 family
HZ311_RS03535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZ311_RS03540	COG4472	Bacterial protein of unknown function (DUF965)
HZ311_RS03555	COG1309	transcriptional regulator
HZ311_RS03570	COG3689	TIGRFAM TIGR03943 family protein
HZ311_RS03575	COG0701	Predicted permease
HZ311_RS03590	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HZ311_RS03595	COG0488	(ABC) transporter
HZ311_RS03600	COG3254	rhamnose metabolic process
HZ311_RS03620	COG1131	(ABC) transporter
HZ311_RS03625	COG4585	Histidine kinase
HZ311_RS03630	COG2197	response regulator
HZ311_RS03670	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZ311_RS03675	COG1177	transmembrane transport
HZ311_RS03680	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZ311_RS03685	COG3842	ATPase activity
HZ311_RS03695	COG0604	alcohol dehydrogenase
HZ311_RS03700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZ311_RS03705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZ311_RS03710	COG4684	Psort location CytoplasmicMembrane, score
HZ311_RS03720	COG0604	alcohol dehydrogenase
HZ311_RS03720	COG3321	synthase
HZ311_RS03720	COG1028	Short-chain dehydrogenase reductase Sdr
HZ311_RS03725	COG1053	succinate dehydrogenase
HZ311_RS03740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZ311_RS03750	COG0708	Exodeoxyribonuclease III
HZ311_RS03765	COG0802	atpase or kinase
HZ311_RS03770	COG0280	phosphate acetyltransferase
HZ311_RS03775	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HZ311_RS03780	COG0561	phosphatase activity
HZ311_RS03810	COG0346	lactoylglutathione lyase activity
HZ311_RS03825	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HZ311_RS03855	COG1263	PTS System
HZ311_RS03855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS03860	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HZ311_RS03905	COG0588	phosphoglycerate mutase activity
HZ311_RS03915	COG1929	Belongs to the glycerate kinase type-1 family
HZ311_RS03925	COG1113	amino acid transport
HZ311_RS03940	COG1464	Belongs to the NlpA lipoprotein family
HZ311_RS03945	COG2011	ABC-type metal ion transport system permease component
HZ311_RS03950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZ311_RS04000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZ311_RS04005	COG0105	UTP biosynthetic process
HZ311_RS04015	COG1368	sulfuric ester hydrolase activity
HZ311_RS04025	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS04040	COG1428	Deoxynucleoside kinase
HZ311_RS04050	COG1611	Belongs to the LOG family
HZ311_RS04070	COG3964	amidohydrolase
HZ311_RS04080	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS04085	COG2188	Transcriptional regulator
HZ311_RS04090	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS04095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS04095	COG1263	PTS System
HZ311_RS04095	COG2190	(PTS) system
HZ311_RS04100	COG3711	transcriptional antiterminator
HZ311_RS04105	COG3764	Sortase (surface protein transpeptidase)
HZ311_RS04115	COG2814	Major facilitator Superfamily
HZ311_RS04120	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HZ311_RS04125	COG0613	PHP domain protein
HZ311_RS04130	COG3639	organic phosphonate transmembrane transporter activity
HZ311_RS04140	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HZ311_RS04150	COG1597	lipid kinase activity
HZ311_RS04155	COG4766	ethanolamine catabolic process
HZ311_RS04160	COG3192	ethanolamine utilization protein
HZ311_RS04165	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HZ311_RS04175	COG4869	propanediol catabolic process
HZ311_RS04190	COG1012	belongs to the aldehyde dehydrogenase family
HZ311_RS04190	COG1454	alcohol dehydrogenase
HZ311_RS04200	COG4816	utilization protein
HZ311_RS04205	COG4302	ethanolamine ammonia-lyase activity
HZ311_RS04210	COG4303	Ethanolamine ammonia lyase large subunit
HZ311_RS04240	COG2096	Adenosyltransferase
HZ311_RS04255	COG2188	Transcriptional regulator
HZ311_RS04260	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ311_RS04260	COG3942	CHAP domain
HZ311_RS04280	COG0210	DNA helicase
HZ311_RS04295	COG1120	ATPase activity
HZ311_RS04305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ311_RS04310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ311_RS04320	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS04360	COG3048	D-serine ammonia-lyase activity
HZ311_RS04380	COG3397	chitin binding
HZ311_RS04530	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HZ311_RS04650	COG0582	viral genome integration into host DNA
HZ311_RS04655	COG0719	Fe-S assembly protein
HZ311_RS04665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZ311_RS04670	COG0719	Fe-S assembly protein
HZ311_RS04680	COG1464	Belongs to the NlpA lipoprotein family
HZ311_RS04685	COG2011	ABC-type metal ion transport system permease component
HZ311_RS04690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZ311_RS04695	COG0509	glycine decarboxylation via glycine cleavage system
HZ311_RS04705	COG0772	Belongs to the SEDS family
HZ311_RS04710	COG0583	DNA-binding transcription factor activity
HZ311_RS04720	COG2855	membrane
HZ311_RS04725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZ311_RS04730	COG0463	Glycosyl transferase, family 2
HZ311_RS04735	COG3409	Peptidoglycan-binding domain 1 protein
HZ311_RS04775	COG3940	Belongs to the glycosyl hydrolase 43 family
HZ311_RS04785	COG0395	ABC-type sugar transport system, permease component
HZ311_RS04805	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZ311_RS04810	COG1263	PTS System
HZ311_RS04810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS04815	COG1737	Transcriptional regulator
HZ311_RS04820	COG0363	glucosamine-6-phosphate deaminase activity
HZ311_RS04830	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZ311_RS04835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ311_RS04835	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ311_RS04860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZ311_RS04870	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZ311_RS04875	COG0009	L-threonylcarbamoyladenylate synthase
HZ311_RS04880	COG2890	protein-(glutamine-N5) methyltransferase activity
HZ311_RS04885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZ311_RS04890	COG1435	thymidine kinase activity
HZ311_RS04900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZ311_RS04905	COG0681	Belongs to the peptidase S26 family
HZ311_RS04920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZ311_RS04925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZ311_RS04930	COG3442	glutamine amidotransferase
HZ311_RS04935	COG0246	Mannitol dehydrogenase
HZ311_RS04940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS04945	COG2213	PTS system mannitol-specific
HZ311_RS04995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS05000	COG3711	transcriptional antiterminator
HZ311_RS05005	COG2213	PTS system mannitol-specific
HZ311_RS05010	COG4975	Glucose uptake
HZ311_RS05015	COG1869	D-ribose catabolic process
HZ311_RS05025	COG1482	cell wall glycoprotein biosynthetic process
HZ311_RS05060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HZ311_RS05075	COG2706	6-phosphogluconolactonase activity
HZ311_RS05085	COG0628	permease
HZ311_RS05095	COG1368	sulfuric ester hydrolase activity
HZ311_RS05100	COG3940	Belongs to the glycosyl hydrolase 43 family
HZ311_RS05105	COG3534	alpha-L-arabinofuranosidase
HZ311_RS05115	COG0395	ABC-type sugar transport system, permease component
HZ311_RS05120	COG1175	transmembrane transport
HZ311_RS05125	COG1653	transport
HZ311_RS05145	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HZ311_RS05150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HZ311_RS05160	COG0789	Transcriptional regulator
HZ311_RS05165	COG1609	Transcriptional regulator
HZ311_RS05175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS05180	COG0459	protein refolding
HZ311_RS05185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HZ311_RS05195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZ311_RS05210	COG5002	protein histidine kinase activity
HZ311_RS05215	COG0745	RESPONSE REGULATOR receiver
HZ311_RS05230	COG1307	EDD domain protein, DegV family
HZ311_RS05245	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HZ311_RS05250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZ311_RS05255	COG3716	PTS system mannose fructose sorbose family IID component
HZ311_RS05260	COG3715	PTS system
HZ311_RS05275	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZ311_RS05275	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZ311_RS05280	COG0383	alpha-mannosidase activity
HZ311_RS05285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS05285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS05285	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS05290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS05305	COG0561	phosphatase activity
HZ311_RS05315	COG4175	Glycine betaine
HZ311_RS05315	COG3448	diguanylate cyclase activity
HZ311_RS05330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HZ311_RS05335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ311_RS05340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ311_RS05350	COG0686	Belongs to the AlaDH PNT family
HZ311_RS05365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ311_RS05410	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS05410	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS05415	COG2188	Transcriptional regulator
HZ311_RS05420	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HZ311_RS05430	COG0628	permease
HZ311_RS05435	COG1285	pathogenesis
HZ311_RS05440	COG0363	glucosamine-6-phosphate deaminase activity
HZ311_RS05445	COG2814	Major facilitator Superfamily
HZ311_RS05470	COG0222	ribosome binding
HZ311_RS05475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZ311_RS05480	COG0081	regulation of translation
HZ311_RS05485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HZ311_RS05490	COG1760	l-serine dehydratase
HZ311_RS05495	COG1760	l-serine dehydratase
HZ311_RS05500	COG0402	S-adenosylhomocysteine deaminase activity
HZ311_RS05505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HZ311_RS05515	COG3842	ATPase activity
HZ311_RS05525	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZ311_RS05535	COG0250	Participates in transcription elongation, termination and antitermination
HZ311_RS05555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZ311_RS05570	COG1597	lipid kinase activity
HZ311_RS05575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZ311_RS05590	COG0500	methyltransferase
HZ311_RS05595	COG3142	Participates in the control of copper homeostasis
HZ311_RS05600	COG2239	Acts as a magnesium transporter
HZ311_RS05605	COG0564	pseudouridine synthase activity
HZ311_RS05610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZ311_RS05615	COG2357	RelA SpoT domain protein
HZ311_RS05640	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZ311_RS05645	COG3959	Transketolase, thiamine diphosphate binding domain
HZ311_RS05660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS05670	COG1063	alcohol dehydrogenase
HZ311_RS05685	COG4862	establishment of competence for transformation
HZ311_RS05690	COG1393	Belongs to the ArsC family
HZ311_RS05705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HZ311_RS05710	COG0419	ATPase involved in DNA repair
HZ311_RS05715	COG0420	3'-5' exonuclease activity
HZ311_RS05720	COG0204	Acyl-transferase
HZ311_RS05725	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HZ311_RS05730	COG2827	Endonuclease containing a URI domain
HZ311_RS05755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ311_RS05760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZ311_RS05765	COG0124	histidyl-tRNA synthetase
HZ311_RS05770	COG0667	Aldo Keto reductase
HZ311_RS05785	COG2124	cytochrome p450
HZ311_RS05790	COG1490	D-aminoacyl-tRNA deacylase activity
HZ311_RS05795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZ311_RS05800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZ311_RS05805	COG2264	protein methyltransferase activity
HZ311_RS05815	COG2094	Belongs to the DNA glycosylase MPG family
HZ311_RS05820	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZ311_RS05835	COG0589	response to stress
HZ311_RS05885	COG1876	peptidase activity
HZ311_RS05895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HZ311_RS05900	COG0827	DNA restriction-modification system
HZ311_RS05925	COG4537	Required for transformation and DNA binding
HZ311_RS05930	COG1459	type II secretion system
HZ311_RS05935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZ311_RS05945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZ311_RS05955	COG4473	ABC transporter
HZ311_RS05960	COG1131	(ABC) transporter
HZ311_RS05965	COG0537	adenosine 5'-monophosphoramidase activity
HZ311_RS05975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZ311_RS05980	COG3481	metal-dependent phosphohydrolase, HD sub domain
HZ311_RS05985	COG4717	serine-type aminopeptidase activity
HZ311_RS06010	COG3507	Belongs to the glycosyl hydrolase 43 family
HZ311_RS06025	COG1073	alpha beta
HZ311_RS06035	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HZ311_RS06040	COG1653	transport
HZ311_RS06050	COG4209	transmembrane transport
HZ311_RS06055	COG0395	ABC-type sugar transport system, permease component
HZ311_RS06060	COG2207	Transcriptional regulator
HZ311_RS06065	COG0246	Mannitol dehydrogenase
HZ311_RS06070	COG2721	sulfolactate sulfo-lyase activity
HZ311_RS06075	COG1904	glucuronate isomerase
HZ311_RS06080	COG2755	lipolytic protein G-D-S-L family
HZ311_RS06090	COG3679	Belongs to the UPF0342 family
HZ311_RS06095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ311_RS06100	COG0564	pseudouridine synthase activity
HZ311_RS06125	COG0383	alpha-mannosidase activity
HZ311_RS06150	COG2207	Transcriptional regulator
HZ311_RS06150	COG4753	response regulator
HZ311_RS06155	COG2972	Histidine kinase
HZ311_RS06170	COG0395	ABC-type sugar transport system, permease component
HZ311_RS06175	COG1175	transmembrane transport
HZ311_RS06180	COG1187	pseudouridine synthase activity
HZ311_RS06185	COG2244	polysaccharide biosynthetic process
HZ311_RS06190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZ311_RS06195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS06205	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZ311_RS06210	COG3711	transcriptional antiterminator
HZ311_RS06210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS06225	COG0495	leucyl-tRNA aminoacylation
HZ311_RS06230	COG1388	LysM domain
HZ311_RS06230	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ311_RS06235	COG0671	phosphoesterase, PA-phosphatase related
HZ311_RS06240	COG1242	4 iron, 4 sulfur cluster binding
HZ311_RS06245	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HZ311_RS06255	COG1132	(ABC) transporter
HZ311_RS06260	COG1132	(ABC) transporter
HZ311_RS06265	COG1607	acyl-coa hydrolase
HZ311_RS06275	COG0477	Major facilitator Superfamily
HZ311_RS06280	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZ311_RS06435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZ311_RS06440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZ311_RS06445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZ311_RS06450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZ311_RS06460	COG0037	tRNA processing
HZ311_RS06465	COG1098	S1 RNA binding domain
HZ311_RS06475	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HZ311_RS06480	COG2244	polysaccharide biosynthetic process
HZ311_RS06485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZ311_RS06490	COG0193	aminoacyl-tRNA hydrolase activity
HZ311_RS06495	COG0039	L-malate dehydrogenase activity
HZ311_RS06525	COG1792	Involved in formation and maintenance of cell shape
HZ311_RS06535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZ311_RS06540	COG1162	GTPase activity
HZ311_RS06545	COG0515	serine threonine protein kinase
HZ311_RS06545	COG2815	serine threonine protein kinase
HZ311_RS06550	COG0631	protein serine/threonine phosphatase activity
HZ311_RS06555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZ311_RS06555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZ311_RS06560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZ311_RS06565	COG0242	peptide deformylase activity
HZ311_RS06570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZ311_RS06575	COG1758	RNA polymerase activity
HZ311_RS06580	COG0194	GDP metabolic process
HZ311_RS06585	COG1561	YicC-like family, N-terminal region
HZ311_RS06610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZ311_RS06615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZ311_RS06620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZ311_RS06625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ311_RS06630	COG1121	(ABC) transporter
HZ311_RS06635	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZ311_RS06635	COG3443	Belongs to the bacterial solute-binding protein 9 family
HZ311_RS06640	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZ311_RS06645	COG0392	lysyltransferase activity
HZ311_RS06645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZ311_RS06650	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZ311_RS06670	COG1418	mRNA catabolic process
HZ311_RS06680	COG1546	Belongs to the CinA family
HZ311_RS06680	COG1058	Belongs to the CinA family
HZ311_RS06685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZ311_RS06690	COG1426	Protein conserved in bacteria
HZ311_RS06695	COG0612	Peptidase, M16
HZ311_RS06700	COG0612	Peptidase, M16
HZ311_RS06705	COG1970	mechanosensitive ion channel activity
HZ311_RS06710	COG2153	protein acetylation
HZ311_RS06715	COG4466	Protein conserved in bacteria
HZ311_RS06725	COG3688	RNA-binding protein containing a PIN domain
HZ311_RS06735	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HZ311_RS06740	COG0215	cysteine-tRNA ligase activity
HZ311_RS06745	COG1045	serine acetyltransferase
HZ311_RS06750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZ311_RS06755	COG4956	integral membrane protein (PIN domain superfamily)
HZ311_RS06765	COG0756	dUTP diphosphatase activity
HZ311_RS06770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZ311_RS06775	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZ311_RS06790	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ311_RS06790	COG1388	LysM domain
HZ311_RS06795	COG1388	LysM domain
HZ311_RS06795	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ311_RS06800	COG0702	epimerase
HZ311_RS06805	COG1959	2 iron, 2 sulfur cluster binding
HZ311_RS06850	COG4499	WXG100 protein secretion system (Wss), protein YukC
HZ311_RS06870	COG4842	Belongs to the WXG100 family
HZ311_RS06880	COG1562	ergosterol biosynthetic process
HZ311_RS06890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZ311_RS06895	COG0842	Transport permease protein
HZ311_RS06900	COG1131	(ABC) transporter
HZ311_RS06905	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZ311_RS06915	COG1070	Carbohydrate kinase
HZ311_RS06925	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZ311_RS06930	COG1129	ABC transporter
HZ311_RS06935	COG3507	Belongs to the glycosyl hydrolase 43 family
HZ311_RS06940	COG2115	Belongs to the xylose isomerase family
HZ311_RS06945	COG1940	carbohydrate kinase activity
HZ311_RS06955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZ311_RS06960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZ311_RS06970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS06980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS07115	COG1396	sequence-specific DNA binding
HZ311_RS07140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZ311_RS07145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZ311_RS07155	COG0165	Argininosuccinate lyase
HZ311_RS07170	COG0783	Belongs to the Dps family
HZ311_RS07180	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HZ311_RS07185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZ311_RS07190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZ311_RS07200	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HZ311_RS07200	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HZ311_RS07225	COG0142	geranyltranstransferase activity
HZ311_RS07245	COG4939	FMN-binding domain protein
HZ311_RS07320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ311_RS07335	COG0542	response to heat
HZ311_RS07340	COG4463	regulation of RNA biosynthetic process
HZ311_RS07420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZ311_RS07425	COG0516	GMP reductase activity
HZ311_RS07425	COG0517	IMP dehydrogenase activity
HZ311_RS07440	COG0012	GTP binding
HZ311_RS07445	COG4481	Protein conserved in bacteria
HZ311_RS07450	COG1475	DNA binding
HZ311_RS07455	COG1192	Involved in chromosome partitioning
HZ311_RS07460	COG0357	Ribosomal RNA small subunit methyltransferase G
HZ311_RS07480	COG0445	tRNA wobble uridine modification
HZ311_RS07485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZ311_RS07495	COG1847	R3H domain protein
HZ311_RS07500	COG0706	membrane insertase activity
HZ311_RS07505	COG0594	ribonuclease P activity
HZ311_RS07510	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HZ311_RS07515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZ311_RS07520	COG0592	DNA-directed DNA polymerase activity
HZ311_RS07525	COG2501	S4 domain
HZ311_RS07530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZ311_RS07535	COG0187	DNA topoisomerase II activity
HZ311_RS07545	COG0360	Binds together with S18 to 16S ribosomal RNA
HZ311_RS07550	COG0629	single-stranded DNA binding
HZ311_RS07555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZ311_RS07565	COG0359	binds to the 23S rRNA
HZ311_RS07570	COG0305	Participates in initiation and elongation during chromosome replication
HZ311_RS07575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZ311_RS07585	COG0488	(ABC) transporter
HZ311_RS07595	COG0028	Belongs to the TPP enzyme family
HZ311_RS07600	COG0673	inositol 2-dehydrogenase activity
HZ311_RS07635	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS07640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS07650	COG1694	Mazg nucleotide pyrophosphohydrolase
HZ311_RS07665	COG1132	(ABC) transporter
HZ311_RS07685	COG2011	ABC-type metal ion transport system permease component
HZ311_RS07690	COG1464	Belongs to the NlpA lipoprotein family
HZ311_RS07730	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HZ311_RS07750	COG1653	transport
HZ311_RS07800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZ311_RS07800	COG0519	Catalyzes the synthesis of GMP from XMP
HZ311_RS07805	COG1072	(Pantothenic acid kinase))
HZ311_RS07810	COG0583	DNA-binding transcription factor activity
HZ311_RS07815	COG2813	Specifically methylates the guanine in position
HZ311_RS07820	COG1609	Transcriptional regulator
HZ311_RS07825	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HZ311_RS07830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HZ311_RS07835	COG0295	cytidine deaminase activity
HZ311_RS07840	COG1744	ABC transporter substrate-binding protein PnrA-like
HZ311_RS07860	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HZ311_RS07870	COG0813	purine-nucleoside phosphorylase activity
HZ311_RS07885	COG2197	response regulator
HZ311_RS07890	COG0588	phosphoglycerate mutase activity
HZ311_RS07895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZ311_RS07900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HZ311_RS07905	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZ311_RS07910	COG0049	tRNA binding
HZ311_RS07915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZ311_RS07920	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZ311_RS07925	COG0051	transcription antitermination factor activity, RNA binding
HZ311_RS07930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZ311_RS07935	COG0088	Forms part of the polypeptide exit tunnel
HZ311_RS07940	COG0089	rRNA binding
HZ311_RS07945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZ311_RS07950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZ311_RS07955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZ311_RS07960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZ311_RS07965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZ311_RS07970	COG0255	Belongs to the universal ribosomal protein uL29 family
HZ311_RS07975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZ311_RS07980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HZ311_RS07985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZ311_RS07990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZ311_RS07995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZ311_RS08000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZ311_RS08005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZ311_RS08010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZ311_RS08015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HZ311_RS08020	COG1841	ribosomal large subunit assembly
HZ311_RS08025	COG0200	Binds to the 23S rRNA
HZ311_RS08030	COG0201	protein transport
HZ311_RS08035	COG0563	adenylate kinase activity
HZ311_RS08040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZ311_RS08045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZ311_RS08050	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZ311_RS08055	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HZ311_RS08060	COG0202	RNA polymerase activity
HZ311_RS08065	COG0203	ribosomal protein L17
HZ311_RS08070	COG1122	ATPase activity
HZ311_RS08075	COG1122	ATPase activity
HZ311_RS08095	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZ311_RS08105	COG1461	Dihydroxyacetone kinase
HZ311_RS08110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZ311_RS08115	COG0416	fatty acid biosynthetic process
HZ311_RS08120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZ311_RS08130	COG4608	Belongs to the ABC transporter superfamily
HZ311_RS08135	COG0601	transmembrane transport
HZ311_RS08160	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HZ311_RS08170	COG1396	sequence-specific DNA binding
HZ311_RS08175	COG0571	ribonuclease III activity
HZ311_RS08180	COG1196	nuclear chromosome segregation
HZ311_RS08185	COG0561	phosphatase activity
HZ311_RS08190	COG0552	protein localization to endoplasmic reticulum
HZ311_RS08195	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZ311_RS08195	COG2918	glutathione biosynthetic process
HZ311_RS08205	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ311_RS08210	COG4605	iron ion homeostasis
HZ311_RS08215	COG4604	ABC transporter, ATP-binding protein
HZ311_RS08220	COG4607	ABC-type enterochelin transport system periplasmic component
HZ311_RS08245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZ311_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
HZ311_RS08270	COG1268	BioY protein
HZ311_RS08275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZ311_RS08290	COG0561	phosphatase activity
HZ311_RS08295	COG1692	metallophosphoesterase
HZ311_RS08305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZ311_RS08315	COG0424	maF-like protein
HZ311_RS08335	COG2188	Transcriptional regulator
HZ311_RS08350	COG1263	PTS System
HZ311_RS08350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS08355	COG0632	four-way junction helicase activity
HZ311_RS08360	COG2255	four-way junction helicase activity
HZ311_RS08370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ311_RS08380	COG1114	Component of the transport system for branched-chain amino acids
HZ311_RS08385	COG1126	abc transporter atp-binding protein
HZ311_RS08390	COG0765	amino acid transport
HZ311_RS08400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZ311_RS08405	COG0110	maltose O-acetyltransferase activity
HZ311_RS08410	COG1827	regulation of RNA biosynthetic process
HZ311_RS08435	COG0242	peptide deformylase activity
HZ311_RS08440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HZ311_RS08445	COG1185	polyribonucleotide nucleotidyltransferase activity
HZ311_RS08455	COG3158	transport of potassium into the cell
HZ311_RS08465	COG1253	flavin adenine dinucleotide binding
HZ311_RS08470	COG0534	Mate efflux family protein
HZ311_RS08480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HZ311_RS08485	COG1187	pseudouridine synthase activity
HZ311_RS08500	COG1011	Hydrolase
HZ311_RS08505	COG0572	uridine kinase
HZ311_RS08510	COG4974	Belongs to the 'phage' integrase family
HZ311_RS08525	COG1396	sequence-specific DNA binding
HZ311_RS08645	COG0270	DNA (cytosine-5-)-methyltransferase activity
HZ311_RS08820	COG1196	nuclear chromosome segregation
HZ311_RS08820	COG0739	heme binding
HZ311_RS08820	COG0741	lytic transglycosylase activity
HZ311_RS08850	COG4824	toxin secretion phage lysis holin
HZ311_RS08900	COG1671	Belongs to the UPF0178 family
HZ311_RS08915	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZ311_RS08920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZ311_RS08935	COG0736	holo-[acyl-carrier-protein] synthase activity
HZ311_RS08945	COG2337	Toxic component of a toxin-antitoxin (TA) module
HZ311_RS08955	COG0531	amino acid
HZ311_RS08970	COG1174	glycine betaine transport
HZ311_RS08990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HZ311_RS09005	COG0343	queuine tRNA-ribosyltransferase activity
HZ311_RS09010	COG1862	Preprotein translocase
HZ311_RS09015	COG1012	belongs to the aldehyde dehydrogenase family
HZ311_RS09015	COG1454	alcohol dehydrogenase
HZ311_RS09025	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HZ311_RS09055	COG1414	Transcriptional regulator
HZ311_RS09060	COG0800	Aldolase
HZ311_RS09070	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HZ311_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
HZ311_RS09080	COG1304	FMN binding
HZ311_RS09095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HZ311_RS09100	COG1428	Deoxynucleoside kinase
HZ311_RS09105	COG3397	chitin binding
HZ311_RS09110	COG3397	chitin binding
HZ311_RS09115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZ311_RS09125	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZ311_RS09155	COG0824	Thioesterase
HZ311_RS09160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZ311_RS09170	COG2188	Transcriptional regulator
HZ311_RS09175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS09180	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS09200	COG1012	belongs to the aldehyde dehydrogenase family
HZ311_RS09225	COG1363	Peptidase, m42
HZ311_RS09230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZ311_RS09245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ311_RS09250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ311_RS09255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZ311_RS09285	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HZ311_RS09290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS09290	COG3711	transcriptional antiterminator
HZ311_RS09310	COG4821	SIS domain
HZ311_RS09360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZ311_RS09370	COG0477	Major facilitator Superfamily
HZ311_RS09375	COG0549	Belongs to the carbamate kinase family
HZ311_RS09385	COG1263	PTS System
HZ311_RS09385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS09385	COG2190	(PTS) system
HZ311_RS09390	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS09395	COG3711	transcriptional antiterminator
HZ311_RS09400	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZ311_RS09415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZ311_RS09420	COG0667	Aldo Keto reductase
HZ311_RS09425	COG0681	Belongs to the peptidase S26 family
HZ311_RS09430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS09435	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZ311_RS09440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS09465	COG1063	alcohol dehydrogenase
HZ311_RS09485	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
HZ311_RS09490	COG1518	maintenance of DNA repeat elements
HZ311_RS09495	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HZ311_RS09530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZ311_RS09550	COG1846	Transcriptional regulator
HZ311_RS09555	COG0456	acetyltransferase
HZ311_RS09575	COG2252	PERMEase
HZ311_RS09625	COG1278	Cold shock
HZ311_RS09640	COG0366	Alpha amylase catalytic
HZ311_RS09650	COG1902	pentaerythritol trinitrate reductase activity
HZ311_RS09660	COG0656	L-ascorbic acid biosynthetic process
HZ311_RS09670	COG0577	efflux transmembrane transporter activity
HZ311_RS09675	COG1136	(ABC) transporter
HZ311_RS09695	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZ311_RS09705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZ311_RS09710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZ311_RS09715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZ311_RS09720	COG1454	alcohol dehydrogenase
HZ311_RS09725	COG0110	maltose O-acetyltransferase activity
HZ311_RS09735	COG4806	L-rhamnose isomerase
HZ311_RS09740	COG1070	Carbohydrate kinase
HZ311_RS09750	COG2207	Transcriptional regulator
HZ311_RS09750	COG1609	Transcriptional regulator
HZ311_RS09760	COG1193	negative regulation of DNA recombination
HZ311_RS09765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZ311_RS09775	COG1609	Transcriptional regulator
HZ311_RS09780	COG0561	phosphatase activity
HZ311_RS09785	COG1937	Protein conserved in bacteria
HZ311_RS09790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZ311_RS09795	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZ311_RS09805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS09805	COG2190	(PTS) system
HZ311_RS09805	COG1263	PTS System
HZ311_RS09815	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HZ311_RS09820	COG2376	Dihydroxyacetone kinase
HZ311_RS09825	COG1461	Dihydroxyacetone kinase
HZ311_RS09845	COG0531	amino acid
HZ311_RS09850	COG1609	Transcriptional regulator
HZ311_RS09860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZ311_RS09870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS09870	COG1263	PTS System
HZ311_RS09870	COG2190	(PTS) system
HZ311_RS09885	COG3479	Phenolic acid decarboxylase
HZ311_RS09890	COG1695	Transcriptional regulator
HZ311_RS09900	COG2814	Major facilitator Superfamily
HZ311_RS09920	COG0577	efflux transmembrane transporter activity
HZ311_RS09920	COG1136	(ABC) transporter
HZ311_RS09930	COG3850	Histidine kinase
HZ311_RS09930	COG5002	protein histidine kinase activity
HZ311_RS09970	COG1136	(ABC) transporter
HZ311_RS09985	COG1737	Transcriptional regulator
HZ311_RS09990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS09990	COG1263	PTS System
HZ311_RS09995	COG1486	melibiose metabolic process
HZ311_RS10015	COG3942	CHAP domain
HZ311_RS10015	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ311_RS10020	COG1609	Transcriptional regulator
HZ311_RS10040	COG0628	permease
HZ311_RS10045	COG0366	Alpha amylase catalytic
HZ311_RS10050	COG0628	permease
HZ311_RS10055	COG3443	Belongs to the bacterial solute-binding protein 9 family
HZ311_RS10055	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZ311_RS10080	COG0210	DNA helicase
HZ311_RS10085	COG1393	Belongs to the ArsC family
HZ311_RS10090	COG1393	Belongs to the ArsC family
HZ311_RS10115	COG0386	Belongs to the glutathione peroxidase family
HZ311_RS10120	COG1854	S-ribosylhomocysteine lyase activity
HZ311_RS10125	COG0626	cystathionine gamma-synthase activity
HZ311_RS10130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZ311_RS10135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZ311_RS10165	COG1272	protein, Hemolysin III
HZ311_RS10170	COG0019	diaminopimelate decarboxylase activity
HZ311_RS10175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZ311_RS10185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZ311_RS10190	COG2171	N-acyltransferase activity
HZ311_RS10195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZ311_RS10200	COG0527	aspartate kinase activity
HZ311_RS10205	COG1473	amidohydrolase
HZ311_RS10210	COG0436	Aminotransferase
HZ311_RS10215	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZ311_RS10240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS10240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ311_RS10240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS10245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS10245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS10245	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZ311_RS10250	COG3684	Belongs to the aldolase LacD family
HZ311_RS10255	COG2188	Transcriptional regulator
HZ311_RS10260	COG2222	sugar isomerase
HZ311_RS10265	COG3684	Belongs to the aldolase LacD family
HZ311_RS10270	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS10270	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS10275	COG3715	PTS system
HZ311_RS10280	COG3716	PTS system mannose fructose sorbose family IID component
HZ311_RS10290	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS10305	COG2365	Tyrosine phosphatase family
HZ311_RS10325	COG1012	belongs to the aldehyde dehydrogenase family
HZ311_RS10390	COG1595	DNA-templated transcription, initiation
HZ311_RS10410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZ311_RS10415	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HZ311_RS10420	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZ311_RS10425	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZ311_RS10440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZ311_RS10445	COG0077	Prephenate dehydratase
HZ311_RS10460	COG0693	protein deglycase activity
HZ311_RS10465	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HZ311_RS10475	COG2207	Transcriptional regulator
HZ311_RS10480	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZ311_RS10495	COG2188	Transcriptional regulator
HZ311_RS10515	COG1263	PTS System
HZ311_RS10515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS10515	COG2190	(PTS) system
HZ311_RS10560	COG4932	domain protein
HZ311_RS10560	COG4886	Leucine-rich repeat (LRR) protein
HZ311_RS10590	COG3711	transcriptional antiterminator
HZ311_RS10630	COG2315	Protein conserved in bacteria
HZ311_RS10650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ311_RS10655	COG1136	(ABC) transporter
HZ311_RS10660	COG0577	efflux transmembrane transporter activity
HZ311_RS10665	COG0745	RESPONSE REGULATOR receiver
HZ311_RS10670	COG5002	protein histidine kinase activity
HZ311_RS10675	COG1113	amino acid transport
HZ311_RS10680	COG1121	(ABC) transporter
HZ311_RS10685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ311_RS10700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZ311_RS10705	COG1652	LysM domain
HZ311_RS10705	COG2823	Periplasmic or secreted lipoprotein
HZ311_RS10710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZ311_RS10715	COG0477	Major facilitator Superfamily
HZ311_RS10725	COG1438	arginine binding
HZ311_RS10735	COG3546	catalase activity
HZ311_RS10740	COG0745	RESPONSE REGULATOR receiver
HZ311_RS10745	COG0642	Histidine kinase
HZ311_RS10750	COG4975	Glucose uptake
HZ311_RS10755	COG0531	amino acid
HZ311_RS10760	COG3853	Toxic anion resistance protein (TelA)
HZ311_RS10770	COG0494	nUDIX hydrolase
HZ311_RS10780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HZ311_RS10785	COG1335	isochorismatase
HZ311_RS10795	COG3590	peptidase
HZ311_RS10805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZ311_RS10810	COG1104	cysteine desulfurase activity
HZ311_RS10865	COG0482	sulfurtransferase activity
HZ311_RS10870	COG2814	Major facilitator Superfamily
HZ311_RS10895	COG0765	amino acid transport
HZ311_RS10900	COG1126	abc transporter atp-binding protein
HZ311_RS10905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ311_RS10910	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS10920	COG1280	lysine exporter protein (LysE YggA)
HZ311_RS10920	COG1674	ftsk spoiiie
HZ311_RS10935	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZ311_RS10945	COG4166	transmembrane transport
HZ311_RS10955	COG0601	transmembrane transport
HZ311_RS10960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZ311_RS10965	COG0444	Belongs to the ABC transporter superfamily
HZ311_RS10970	COG4608	Belongs to the ABC transporter superfamily
HZ311_RS10975	COG0675	Transposase, IS605 OrfB family
HZ311_RS11000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ311_RS11000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ311_RS11010	COG3177	Filamentation induced by cAMP protein fic
HZ311_RS11020	COG0531	amino acid
HZ311_RS11025	COG0084	hydrolase, TatD family'
HZ311_RS11030	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HZ311_RS11035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZ311_RS11045	COG3842	ATPase activity
HZ311_RS11060	COG1803	Methylglyoxal synthase
HZ311_RS11070	COG1132	(ABC) transporter
HZ311_RS11080	COG3397	chitin binding
HZ311_RS11090	COG3469	chitinase activity
HZ311_RS11095	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZ311_RS11110	COG4821	SIS domain
HZ311_RS11115	COG1288	antiporter activity
HZ311_RS11120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZ311_RS11130	COG1136	(ABC) transporter
HZ311_RS11135	COG0577	efflux transmembrane transporter activity
HZ311_RS11150	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZ311_RS11155	COG4109	DRTGG domain
HZ311_RS11160	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HZ311_RS11165	COG2824	Alkylphosphonate utilization operon protein PhnA
HZ311_RS11170	COG2738	Putative neutral zinc metallopeptidase
HZ311_RS11195	COG0590	tRNA wobble adenosine to inosine editing
HZ311_RS11205	COG0737	Belongs to the 5'-nucleotidase family
HZ311_RS11210	COG4470	Protein conserved in bacteria
HZ311_RS11225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HZ311_RS11230	COG0492	ferredoxin-NADP+ reductase activity
HZ311_RS11245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZ311_RS11250	COG1098	S1 RNA binding domain
HZ311_RS11295	COG3579	cysteine-type endopeptidase activity
HZ311_RS11315	COG1801	Protein of unknown function DUF72
HZ311_RS11320	COG0561	phosphatase activity
HZ311_RS11330	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HZ311_RS11335	COG1104	cysteine desulfurase activity
HZ311_RS11340	COG0301	tRNA thio-modification
HZ311_RS11345	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HZ311_RS11350	COG0525	valine-tRNA ligase activity
HZ311_RS11355	COG0285	dihydrofolate synthase activity
HZ311_RS11360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZ311_RS11370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZ311_RS11555	COG3728	DNA packaging
HZ311_RS11555	COG5484	DNA packaging
HZ311_RS11560	COG1783	phage Terminase large subunit
HZ311_RS11685	COG1278	Cold shock
HZ311_RS11705	COG1132	(ABC) transporter
HZ311_RS11710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZ311_RS11715	COG0740	serine-type endopeptidase activity
HZ311_RS11725	COG0584	glycerophosphoryl diester phosphodiesterase
HZ311_RS11730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZ311_RS11740	COG0789	Transcriptional regulator
HZ311_RS11745	COG0174	glutamine synthetase
HZ311_RS11750	COG0504	CTP synthase activity
HZ311_RS11760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZ311_RS11765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZ311_RS11770	COG0254	rRNA binding
HZ311_RS11775	COG5297	Belongs to the glycosyl hydrolase family 6
HZ311_RS11775	COG4733	cellulase activity
HZ311_RS11780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS11805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZ311_RS11810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZ311_RS11815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZ311_RS11820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZ311_RS11825	COG3870	Protein conserved in bacteria
HZ311_RS11830	COG0470	DNA polymerase III
HZ311_RS11835	COG1774	PSP1 C-terminal conserved region
HZ311_RS11840	COG4467	Involved in initiation control of chromosome replication
HZ311_RS11855	COG0602	queuosine metabolic process
HZ311_RS11860	COG1328	CTP reductase activity
HZ311_RS11865	COG1136	(ABC) transporter
HZ311_RS11870	COG0577	efflux transmembrane transporter activity
HZ311_RS11880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZ311_RS11885	COG1696	Membrane protein involved in D-alanine export
HZ311_RS11890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZ311_RS11895	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HZ311_RS11900	COG1363	Peptidase, m42
HZ311_RS11910	COG1234	tRNA 3'-trailer cleavage
HZ311_RS11915	COG0095	Lipoate-protein ligase
HZ311_RS11930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZ311_RS11965	COG3759	membrane
HZ311_RS11970	COG0659	secondary active sulfate transmembrane transporter activity
HZ311_RS11975	COG0789	Transcriptional regulator
HZ311_RS11985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZ311_RS11995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZ311_RS12000	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZ311_RS12000	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZ311_RS12005	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZ311_RS12005	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS12015	COG3715	PTS system
HZ311_RS12020	COG3716	PTS system mannose fructose sorbose family IID component
HZ311_RS12030	COG2261	transglycosylase associated protein
HZ311_RS12035	COG0006	proline dipeptidase activity
HZ311_RS12040	COG1302	Protein conserved in bacteria
HZ311_RS12045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZ311_RS12050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZ311_RS12055	COG1570	exodeoxyribonuclease VII activity
HZ311_RS12060	COG1722	exodeoxyribonuclease VII activity
HZ311_RS12065	COG0142	geranyltranstransferase activity
HZ311_RS12070	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HZ311_RS12075	COG1438	arginine binding
HZ311_RS12080	COG0497	DNA recombination
HZ311_RS12135	COG0768	penicillin binding
HZ311_RS12170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZ311_RS12175	COG1799	cell septum assembly
HZ311_RS12185	COG2302	S4 RNA-binding domain
HZ311_RS12190	COG3599	regulation of cell shape
HZ311_RS12195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZ311_RS12205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZ311_RS12210	COG1321	iron dependent repressor
HZ311_RS12210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ311_RS12225	COG0673	inositol 2-dehydrogenase activity
HZ311_RS12235	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZ311_RS12235	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HZ311_RS12240	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS12250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS12290	COG2309	aminopeptidase activity
HZ311_RS12305	COG0716	FMN binding
HZ311_RS12310	COG0024	Methionine aminopeptidase
HZ311_RS12315	COG1295	ribonuclease BN
HZ311_RS12320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZ311_RS12335	COG0463	Glycosyl transferase, family 2
HZ311_RS12340	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HZ311_RS12350	COG1088	dTDP-glucose 4,6-dehydratase activity
HZ311_RS12355	COG1091	dTDP-4-dehydrorhamnose reductase activity
HZ311_RS12370	COG1682	transport, permease protein
HZ311_RS12375	COG1134	teichoic acid transport
HZ311_RS12385	COG1216	Glycosyl transferase, family 2
HZ311_RS12385	COG0438	transferase activity, transferring glycosyl groups
HZ311_RS12390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZ311_RS12395	COG1216	Glycosyl transferase, family 2
HZ311_RS12400	COG3475	LICD family
HZ311_RS12415	COG1442	glycosyl transferase family 8
HZ311_RS12415	COG1216	Glycosyl transferase, family 2
HZ311_RS12425	COG3475	LICD family
HZ311_RS12450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZ311_RS12455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZ311_RS12465	COG4585	Histidine kinase
HZ311_RS12470	COG2197	response regulator
HZ311_RS12480	COG2239	Acts as a magnesium transporter
HZ311_RS12485	COG0569	domain protein
HZ311_RS12490	COG4841	protein insertion into membrane
HZ311_RS12505	COG2246	polysaccharide biosynthetic process
HZ311_RS12510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZ311_RS12515	COG1278	Cold shock
HZ311_RS12540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZ311_RS12545	COG1316	TRANSCRIPTIONal
HZ311_RS12555	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HZ311_RS12565	COG3397	chitin binding
HZ311_RS12575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZ311_RS12580	COG2137	regulation of response to DNA damage stimulus
HZ311_RS12585	COG1194	a g-specific adenine glycosylase
HZ311_RS12590	COG3557	Belongs to the UPF0374 family
HZ311_RS12600	COG0628	permease
HZ311_RS12605	COG1253	flavin adenine dinucleotide binding
HZ311_RS12610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZ311_RS12625	COG0542	response to heat
HZ311_RS12630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ311_RS12635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZ311_RS12645	COG0438	transferase activity, transferring glycosyl groups
HZ311_RS12650	COG2084	Dehydrogenase
HZ311_RS12655	COG4703	Protein of unknown function (DUF1797)
HZ311_RS12665	COG1846	Transcriptional regulator
HZ311_RS12670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZ311_RS12680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZ311_RS12695	COG0511	ligase activity, forming carbon-carbon bonds
HZ311_RS12700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZ311_RS12705	COG0439	Biotin carboxylase
HZ311_RS12710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HZ311_RS12715	COG0825	malonyl-CoA metabolic process
HZ311_RS12740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ311_RS12745	COG0765	amino acid transport
HZ311_RS12750	COG1126	abc transporter atp-binding protein
HZ311_RS12755	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HZ311_RS12760	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HZ311_RS12765	COG1534	Rna-binding protein
HZ311_RS12770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZ311_RS12775	COG1713	HD superfamily hydrolase involved in NAD metabolism
HZ311_RS12780	COG0799	negative regulation of ribosome biogenesis
HZ311_RS12785	COG2226	methyltransferase
HZ311_RS12790	COG1323	Belongs to the UPF0348 family
HZ311_RS12795	COG0217	transcriptional regulatory protein
HZ311_RS12805	COG3973	AAA domain
HZ311_RS12810	COG2217	Heavy metal translocating P-type atpase
HZ311_RS12815	COG1942	4-Oxalocrotonate Tautomerase
HZ311_RS12820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZ311_RS12835	COG1737	Transcriptional regulator
HZ311_RS12840	COG0768	penicillin binding
HZ311_RS12845	COG0561	phosphatase activity
HZ311_RS12850	COG2252	PERMEase
HZ311_RS12855	COG2814	Major facilitator Superfamily
HZ311_RS12865	COG0587	DNA-directed DNA polymerase activity
HZ311_RS12870	COG0205	6-phosphofructokinase activity
HZ311_RS12880	COG0583	DNA-binding transcription factor activity
HZ311_RS12895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZ311_RS12900	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HZ311_RS12905	COG0745	RESPONSE REGULATOR receiver
HZ311_RS13020	COG1609	Transcriptional regulator
HZ311_RS13025	COG1609	Transcriptional regulator
HZ311_RS13050	COG1175	transmembrane transport
HZ311_RS13055	COG0395	ABC-type sugar transport system, permease component
HZ311_RS13105	COG0400	carboxylic ester hydrolase activity
HZ311_RS13110	COG0346	lactoylglutathione lyase activity
HZ311_RS13115	COG2188	Transcriptional regulator
HZ311_RS13120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZ311_RS13125	COG2723	6-phospho-beta-galactosidase activity
HZ311_RS13130	COG0589	response to stress
HZ311_RS13135	COG0351	phosphomethylpyrimidine kinase
HZ311_RS13140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZ311_RS13145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZ311_RS13155	COG3425	synthase
HZ311_RS13160	COG0183	Belongs to the thiolase family
HZ311_RS13175	COG1316	TRANSCRIPTIONal
HZ311_RS13190	COG0656	L-ascorbic acid biosynthetic process
HZ311_RS13220	COG0392	lysyltransferase activity
HZ311_RS13220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HZ311_RS13230	COG0741	lytic transglycosylase activity
HZ311_RS13240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZ311_RS13245	COG0358	DNA primase activity
HZ311_RS13250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZ311_RS13260	COG2996	Protein conserved in bacteria
HZ311_RS13265	COG0735	belongs to the Fur family
HZ311_RS13270	COG4974	Belongs to the 'phage' integrase family
HZ311_RS13280	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZ311_RS13285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZ311_RS13290	COG1187	pseudouridine synthase activity
HZ311_RS13295	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HZ311_RS13300	COG1288	antiporter activity
HZ311_RS13305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZ311_RS13315	COG1141	Ferredoxin
HZ311_RS13325	COG0514	ATP-dependent DNA helicase (RecQ)
HZ311_RS13335	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZ311_RS13340	COG0539	negative regulation of cytoplasmic translation
HZ311_RS13345	COG1160	GTP binding
HZ311_RS13350	COG0776	regulation of translation
HZ311_RS13360	COG0457	Tetratricopeptide repeat
HZ311_RS13365	COG5582	Belongs to the UPF0302 family
HZ311_RS13370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ311_RS13375	COG1694	Mazg nucleotide pyrophosphohydrolase
HZ311_RS13380	COG0617	tRNA 3'-terminal CCA addition
HZ311_RS13395	COG0025	NhaP-type Na H and K H
HZ311_RS13400	COG0488	(ABC) transporter
HZ311_RS13405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZ311_RS13415	COG1307	EDD domain protein, DegV family
HZ311_RS13420	COG2755	lipolytic protein G-D-S-L family
HZ311_RS13425	COG4698	Protein conserved in bacteria
HZ311_RS13435	COG4479	Belongs to the UPF0346 family
HZ311_RS13440	COG0681	Belongs to the peptidase S26 family
HZ311_RS13470	COG0758	DNA mediated transformation
HZ311_RS13475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZ311_RS13480	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HZ311_RS13485	COG4974	Belongs to the 'phage' integrase family
HZ311_RS13490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HZ311_RS13495	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HZ311_RS13500	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HZ311_RS13510	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HZ311_RS13515	COG1832	CoA-binding protein
HZ311_RS13520	COG0187	DNA topoisomerase II activity
HZ311_RS13530	COG1882	Formate acetyltransferase
HZ311_RS13535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZ311_RS13540	COG1227	inorganic diphosphatase activity
HZ311_RS13555	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HZ311_RS13560	COG1073	alpha beta
HZ311_RS13565	COG1609	Transcriptional regulator
HZ311_RS13575	COG0604	alcohol dehydrogenase
HZ311_RS13580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ311_RS13595	COG1125	glycine betaine transport
HZ311_RS13595	COG0517	IMP dehydrogenase activity
HZ311_RS13625	COG3942	CHAP domain
HZ311_RS13625	COG1388	LysM domain
HZ311_RS13655	COG0436	Aminotransferase
HZ311_RS13670	COG0789	Transcriptional regulator
HZ311_RS13675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZ311_RS13695	COG2268	Band 7 protein
HZ311_RS13705	COG4129	membrane
HZ311_RS13720	COG1876	peptidase activity
HZ311_RS13725	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ311_RS13735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZ311_RS13740	COG2233	PERMEase
HZ311_RS13750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HZ311_RS13755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HZ311_RS13760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZ311_RS13770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZ311_RS13775	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZ311_RS13780	COG0047	phosphoribosylformylglycinamidine synthase activity
HZ311_RS13785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZ311_RS13795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZ311_RS13800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZ311_RS13805	COG0138	bifunctional purine biosynthesis protein purh
HZ311_RS13810	COG0151	Belongs to the GarS family
HZ311_RS13815	COG4989	oxidoreductase activity
HZ311_RS13825	COG0516	GMP reductase activity
HZ311_RS13830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ311_RS13855	COG4476	Belongs to the UPF0223 family
HZ311_RS13860	COG0483	inositol monophosphate 1-phosphatase activity
HZ311_RS13880	COG0514	ATP-dependent DNA helicase (RecQ)
HZ311_RS13885	COG4838	Belongs to the UPF0358 family
HZ311_RS13890	COG0772	Belongs to the SEDS family
HZ311_RS13895	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HZ311_RS13910	COG4471	UPF0298 protein
HZ311_RS13915	COG0742	ribosomal rna small subunit methyltransferase
HZ311_RS13920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZ311_RS13925	COG3480	Lon protease (S16) C-terminal proteolytic domain
HZ311_RS13935	COG1596	polysaccharide export
HZ311_RS13935	COG1555	photosystem II stabilization
HZ311_RS13940	COG2131	deaminase
HZ311_RS13950	COG1466	dna polymerase III delta subunit
HZ311_RS13955	COG0268	Binds directly to 16S ribosomal RNA
HZ311_RS13965	COG2707	UPF0756 membrane protein
HZ311_RS14000	COG1695	Transcriptional regulator
HZ311_RS14005	COG0488	(ABC) transporter
HZ311_RS14010	COG1968	undecaprenyl-diphosphatase activity
HZ311_RS14025	COG1199	ATP-dependent helicase activity
HZ311_RS14030	COG1666	GTP binding
HZ311_RS14035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ311_RS14040	COG2151	metal-sulfur cluster biosynthetic enzyme
HZ311_RS14045	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZ311_RS14070	COG0582	viral genome integration into host DNA
HZ311_RS14120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZ311_RS14165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ311_RS14175	COG3942	CHAP domain
HZ311_RS14175	COG1388	LysM domain
HZ311_RS14210	COG4990	cell redox homeostasis
HZ311_RS14230	COG3104	oligopeptide transport
HZ311_RS14235	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HZ311_RS14240	COG1074	ATP-dependent DNA helicase activity
HZ311_RS14245	COG1733	regulation of RNA biosynthetic process
HZ311_RS14250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZ311_RS14255	COG0072	phenylalanine-tRNA ligase activity
HZ311_RS14255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ311_RS14265	COG1126	abc transporter atp-binding protein
HZ311_RS14270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ311_RS14275	COG0765	amino acid transport
HZ311_RS14280	COG0765	amino acid transport
HZ311_RS14285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZ311_RS14300	COG0517	IMP dehydrogenase activity
HZ311_RS14305	COG0668	transmembrane transport
HZ311_RS14310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZ311_RS14315	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZ311_RS14320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZ311_RS14325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZ311_RS14340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZ311_RS14350	COG1234	tRNA 3'-trailer cleavage
HZ311_RS14355	COG0300	oxidoreductase activity
HZ311_RS14365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZ311_RS14365	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HZ311_RS14370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZ311_RS14380	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZ311_RS14395	COG1388	LysM domain
HZ311_RS14395	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ311_RS14405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZ311_RS14410	COG0735	belongs to the Fur family
HZ311_RS14415	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZ311_RS14425	COG3935	DnaD domain protein
HZ311_RS14430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZ311_RS14445	COG3397	chitin binding
HZ311_RS14480	COG0791	NLP P60 protein
HZ311_RS14480	COG0741	lytic transglycosylase activity
HZ311_RS14535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZ311_RS14540	COG3331	DNA recombination
HZ311_RS14545	COG4474	Belongs to the UPF0398 family
HZ311_RS14550	COG3599	regulation of cell shape
HZ311_RS14560	COG0116	Belongs to the methyltransferase superfamily
HZ311_RS14570	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HZ311_RS14575	COG1418	mRNA catabolic process
HZ311_RS14590	COG0513	Belongs to the DEAD box helicase family
HZ311_RS14600	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZ311_RS14605	COG4684	Psort location CytoplasmicMembrane, score
HZ311_RS14615	COG0328	RNA-DNA hybrid ribonuclease activity
HZ311_RS14625	COG1278	Cold shock
HZ311_RS14630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HZ311_RS14670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZ311_RS14675	COG0564	pseudouridine synthase activity
HZ311_RS14685	COG2233	PERMEase
HZ311_RS14690	COG0540	Belongs to the ATCase OTCase family
HZ311_RS14695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZ311_RS14700	COG0505	Belongs to the CarA family
HZ311_RS14705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZ311_RS14710	COG0543	2 iron, 2 sulfur cluster binding
HZ311_RS14715	COG0167	dihydroorotate dehydrogenase activity
HZ311_RS14720	COG0284	orotidine-5'-phosphate decarboxylase activity
HZ311_RS14740	COG0583	DNA-binding transcription factor activity
HZ311_RS14750	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HZ311_RS14765	COG4120	Belongs to the binding-protein-dependent transport system permease family
HZ311_RS14770	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HZ311_RS14775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HZ311_RS14845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZ311_RS14855	COG0456	acetyltransferase
HZ311_RS14900	COG0433	COG0433 Predicted ATPase
HZ311_RS14930	COG0739	heme binding
HZ311_RS14930	COG0741	lytic transglycosylase activity
HZ311_RS14930	COG1196	nuclear chromosome segregation
HZ311_RS14950	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZ311_RS14950	COG3942	CHAP domain
HZ311_RS15000	COG1192	Involved in chromosome partitioning
HZ311_RS15065	COG0726	polysaccharide deacetylase
HZ311_RS15080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZ311_RS15085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZ311_RS15090	COG2184	nucleotidyltransferase activity
HZ311_RS15155	COG0629	single-stranded DNA binding
HZ311_RS15210	COG0433	COG0433 Predicted ATPase
HZ311_RS15230	COG1396	sequence-specific DNA binding
HZ311_RS15250	COG2946	Replication initiation factor
HZ311_RS15255	COG1674	ftsk spoiiie
HZ311_RS15305	COG1192	Involved in chromosome partitioning
HZ311_RS15360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZ311_RS15380	COG1278	Cold shock
HZ311_RS15480	COG5002	protein histidine kinase activity
HZ311_RS15485	COG0745	RESPONSE REGULATOR receiver
HZ311_RS15490	COG0577	efflux transmembrane transporter activity
HZ311_RS15495	COG1136	(ABC) transporter
HZ311_RS15500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ311_RS15530	COG4886	Leucine-rich repeat (LRR) protein
HZ311_RS15530	COG4932	domain protein
HZ311_RS15610	COG0270	DNA (cytosine-5-)-methyltransferase activity
HZ311_RS15620	COG3843	relaxase mobilization nuclease domain protein