locus-tag	class	description
EHW98_RS00005	COG0716	FMN binding
EHW98_RS00010	COG1522	sequence-specific DNA binding
EHW98_RS00020	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EHW98_RS00030	COG3158	transport of potassium into the cell
EHW98_RS00050	COG3111	PFAM Bacterial OB fold (BOF) protein
EHW98_RS00075	COG1129	ABC transporter
EHW98_RS00080	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW98_RS00085	COG1879	ABC-type sugar transport system periplasmic component
EHW98_RS00090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW98_RS00095	COG1609	Transcriptional regulator
EHW98_RS00100	COG0477	Major facilitator Superfamily
EHW98_RS00130	COG0746	molybdenum cofactor guanylyltransferase activity
EHW98_RS00135	COG3084	Protein conserved in bacteria
EHW98_RS00150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHW98_RS00150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHW98_RS00160	COG3078	GTPase activator activity
EHW98_RS00175	COG3852	Histidine kinase
EHW98_RS00190	COG1011	Hydrolase
EHW98_RS00200	COG1490	D-aminoacyl-tRNA deacylase activity
EHW98_RS00205	COG0456	acetyltransferase
EHW98_RS00210	COG1187	pseudouridine synthase activity
EHW98_RS00215	COG2982	Protein involved in outer membrane biogenesis
EHW98_RS00220	COG2233	PERMEase
EHW98_RS00225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EHW98_RS00230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHW98_RS00235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHW98_RS00240	COG1758	RNA polymerase activity
EHW98_RS00245	COG0194	GDP metabolic process
EHW98_RS00255	COG2860	membrane
EHW98_RS00260	COG2197	response regulator
EHW98_RS00270	COG2824	Alkylphosphonate utilization operon protein PhnA
EHW98_RS00325	COG1401	restriction endodeoxyribonuclease activity
EHW98_RS00340	COG1561	YicC-like family, N-terminal region
EHW98_RS00350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EHW98_RS00355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EHW98_RS00360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EHW98_RS00365	COG1309	transcriptional regulator
EHW98_RS00370	COG0756	dUTP diphosphatase activity
EHW98_RS00375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EHW98_RS00380	COG2003	Belongs to the UPF0758 family
EHW98_RS00385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EHW98_RS00395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EHW98_RS00400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EHW98_RS00410	COG1519	Transferase
EHW98_RS00415	COG0859	PFAM glycosyl transferase family 9
EHW98_RS00420	COG0438	transferase activity, transferring glycosyl groups
EHW98_RS00430	COG0859	PFAM glycosyl transferase family 9
EHW98_RS00445	COG1215	transferase activity, transferring glycosyl groups
EHW98_RS00450	COG3307	-O-antigen
EHW98_RS00455	COG0438	transferase activity, transferring glycosyl groups
EHW98_RS00460	COG0859	PFAM glycosyl transferase family 9
EHW98_RS00465	COG0859	PFAM glycosyl transferase family 9
EHW98_RS00470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW98_RS00475	COG2861	carbohydrate metabolic process
EHW98_RS00480	COG4942	peptidase
EHW98_RS00485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHW98_RS00490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHW98_RS00495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EHW98_RS00500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EHW98_RS00510	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EHW98_RS00515	COG2205	protein histidine kinase activity
EHW98_RS00520	COG0745	RESPONSE REGULATOR receiver
EHW98_RS00525	COG3678	ATP-independent chaperone mediated protein folding
EHW98_RS00535	COG0205	6-phosphofructokinase activity
EHW98_RS00540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EHW98_RS00550	COG1295	ribonuclease BN
EHW98_RS00575	COG0149	triose-phosphate isomerase activity
EHW98_RS00585	COG3152	Membrane
EHW98_RS00600	COG2814	Major facilitator Superfamily
EHW98_RS00605	COG1494	fructose-1,6-bisphosphatase
EHW98_RS00620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EHW98_RS00625	COG3074	FtsZ-dependent cytokinesis
EHW98_RS00630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHW98_RS00635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EHW98_RS00640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EHW98_RS00645	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EHW98_RS00650	COG1609	Transcriptional regulator
EHW98_RS00655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EHW98_RS00660	COG0254	rRNA binding
EHW98_RS00665	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EHW98_RS00670	COG0626	cystathionine gamma-synthase activity
EHW98_RS00675	COG0460	homoserine dehydrogenase
EHW98_RS00675	COG0527	aspartate kinase activity
EHW98_RS00685	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EHW98_RS00690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHW98_RS00700	COG0137	argininosuccinate synthase activity
EHW98_RS00705	COG0165	Argininosuccinate lyase
EHW98_RS00710	COG0678	peroxiredoxin activity
EHW98_RS00710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHW98_RS00720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHW98_RS00725	COG1309	transcriptional regulator
EHW98_RS00735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHW98_RS00740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EHW98_RS00775	COG0583	DNA-binding transcription factor activity
EHW98_RS00780	COG3085	chromosome segregation
EHW98_RS00785	COG0606	chelatase, subunit chli
EHW98_RS00800	COG3978	acetolactate synthase activity
EHW98_RS00810	COG0129	dihydroxy-acid dehydratase activity
EHW98_RS00815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EHW98_RS00825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EHW98_RS00840	COG0248	Ppx GppA phosphatase
EHW98_RS00845	COG0513	Belongs to the DEAD box helicase family
EHW98_RS00850	COG3118	belongs to the thioredoxin family
EHW98_RS00855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EHW98_RS00860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EHW98_RS00870	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EHW98_RS00875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EHW98_RS00880	COG1088	dTDP-glucose 4,6-dehydratase activity
EHW98_RS00885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EHW98_RS00890	COG0456	acetyltransferase
EHW98_RS00895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHW98_RS00900	COG2244	polysaccharide biosynthetic process
EHW98_RS00905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EHW98_RS00915	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EHW98_RS00955	COG3071	HemY protein
EHW98_RS00960	COG2959	enzyme of heme biosynthesis
EHW98_RS00965	COG1587	Uroporphyrinogen-III synthase
EHW98_RS00970	COG0181	hydroxymethylbilane synthase activity
EHW98_RS00975	COG3072	Adenylate cyclase
EHW98_RS00985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EHW98_RS00990	COG3159	Protein conserved in bacteria
EHW98_RS01000	COG1011	Hydrolase
EHW98_RS01005	COG0210	DNA helicase
EHW98_RS01010	COG0598	Magnesium transport protein CorA
EHW98_RS01015	COG2050	protein possibly involved in aromatic compounds catabolism
EHW98_RS01020	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
EHW98_RS01025	COG0514	ATP-dependent DNA helicase (RecQ)
EHW98_RS01030	COG1280	lysine exporter protein (LysE YggA)
EHW98_RS01035	COG2267	carboxylic ester hydrolase activity
EHW98_RS01040	COG0561	phosphatase activity
EHW98_RS01045	COG2271	Major facilitator Superfamily
EHW98_RS01050	COG4807	Protein conserved in bacteria
EHW98_RS01055	COG0583	DNA-binding transcription factor activity
EHW98_RS01060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHW98_RS01065	COG0412	Dienelactone hydrolase
EHW98_RS01075	COG1322	Protein conserved in bacteria
EHW98_RS01080	COG2226	methyltransferase
EHW98_RS01090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EHW98_RS01100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHW98_RS01105	COG0805	protein transport
EHW98_RS01120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EHW98_RS01130	COG0183	Belongs to the thiolase family
EHW98_RS01140	COG0006	proline dipeptidase activity
EHW98_RS01145	COG1739	Uncharacterized protein family UPF0029
EHW98_RS01150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHW98_RS01155	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EHW98_RS01185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EHW98_RS01185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EHW98_RS01190	COG1072	(Pantothenic acid kinase))
EHW98_RS01225	COG0250	Participates in transcription elongation, termination and antitermination
EHW98_RS01230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EHW98_RS01235	COG0081	regulation of translation
EHW98_RS01240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EHW98_RS01245	COG0222	ribosome binding
EHW98_RS01250	COG0085	RNA polymerase activity
EHW98_RS01255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EHW98_RS01300	COG4571	Outer membrane protease
EHW98_RS01310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EHW98_RS01315	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EHW98_RS01320	COG2816	NAD+ diphosphatase activity
EHW98_RS01325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EHW98_RS01330	COG1515	deoxyribonuclease V activity
EHW98_RS01350	COG0151	Belongs to the GarS family
EHW98_RS01355	COG0138	bifunctional purine biosynthesis protein purh
EHW98_RS01380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EHW98_RS01385	COG1283	sodium-dependent phosphate transmembrane transporter activity
EHW98_RS01390	COG0527	aspartate kinase activity
EHW98_RS01395	COG0166	Belongs to the GPI family
EHW98_RS01415	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW98_RS01420	COG3223	Belongs to the PsiE family
EHW98_RS01425	COG3161	chorismate lyase activity
EHW98_RS01440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EHW98_RS01445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EHW98_RS01450	COG0534	Mate efflux family protein
EHW98_RS01455	COG3237	CsbD-like
EHW98_RS01460	COG0735	belongs to the Fur family
EHW98_RS01480	COG1403	HNH endonuclease
EHW98_RS01545	COG2246	polysaccharide biosynthetic process
EHW98_RS01560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHW98_RS01585	COG1448	Aminotransferase
EHW98_RS01595	COG2315	Protein conserved in bacteria
EHW98_RS01600	COG1388	LysM domain
EHW98_RS01600	COG1470	cell adhesion involved in biofilm formation
EHW98_RS01605	COG1064	alcohol dehydrogenase
EHW98_RS01610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EHW98_RS01615	COG0629	single-stranded DNA binding
EHW98_RS01620	COG2831	hemolysin activation secretion protein
EHW98_RS01650	COG0625	glutathione transferase activity
EHW98_RS01655	COG2252	PERMEase
EHW98_RS01660	COG0025	NhaP-type Na H and K H
EHW98_RS01665	COG0583	DNA-binding transcription factor activity
EHW98_RS01670	COG1380	Effector of murein hydrolase LrgA
EHW98_RS01675	COG1346	cytolysis
EHW98_RS01685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHW98_RS01690	COG3162	membrane
EHW98_RS01700	COG1301	dicarboxylic acid transport
EHW98_RS01705	COG0840	transmembrane signaling receptor activity
EHW98_RS01725	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EHW98_RS01730	COG5001	Diguanylate cyclase
EHW98_RS01730	COG3300	MHYT domain
EHW98_RS01750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EHW98_RS01765	COG0583	DNA-binding transcription factor activity
EHW98_RS01780	COG0583	DNA-binding transcription factor activity
EHW98_RS01785	COG1280	lysine exporter protein (LysE YggA)
EHW98_RS01795	COG2382	esterase
EHW98_RS01800	COG5383	Protein conserved in bacteria
EHW98_RS01805	COG0561	phosphatase activity
EHW98_RS01815	COG1902	pentaerythritol trinitrate reductase activity
EHW98_RS01825	COG1028	Short-chain dehydrogenase reductase Sdr
EHW98_RS01835	COG4774	siderophore transport
EHW98_RS01845	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EHW98_RS01850	COG0076	glutamate decarboxylase activity
EHW98_RS02025	COG1181	Belongs to the D-alanine--D-alanine ligase family
EHW98_RS02035	COG2890	protein-(glutamine-N5) methyltransferase activity
EHW98_RS02050	COG0124	histidyl-tRNA synthetase
EHW98_RS02065	COG0367	asparagine synthase
EHW98_RS02075	COG2211	Major facilitator Superfamily
EHW98_RS02090	COG1309	transcriptional regulator
EHW98_RS02100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EHW98_RS02105	COG1027	Aspartate ammonia-lyase
EHW98_RS02110	COG3030	protein affecting phage T7 exclusion by the F plasmid
EHW98_RS02115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EHW98_RS02120	COG0459	protein refolding
EHW98_RS02130	COG1509	lysine 2,3-aminomutase activity
EHW98_RS02135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHW98_RS02150	COG3040	lipid binding
EHW98_RS02155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EHW98_RS02160	COG3264	Mechanosensitive ion channel
EHW98_RS02160	COG1511	domain protein
EHW98_RS02165	COG0688	phosphatidylethanolamine metabolic process
EHW98_RS02170	COG1162	GTPase activity
EHW98_RS02175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EHW98_RS02200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EHW98_RS02200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EHW98_RS02205	COG0802	atpase or kinase
EHW98_RS02210	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHW98_RS02215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EHW98_RS02220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EHW98_RS02230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EHW98_RS02235	COG0330	HflC and HflK could
EHW98_RS02240	COG0330	HflC and HflK could
EHW98_RS02245	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EHW98_RS02250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EHW98_RS02255	COG0557	exoribonuclease II activity
EHW98_RS02260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHW98_RS02270	COG0840	transmembrane signaling receptor activity
EHW98_RS02275	COG1073	alpha beta
EHW98_RS02280	COG0360	Binds together with S18 to 16S ribosomal RNA
EHW98_RS02285	COG2965	DNA replication, synthesis of RNA primer
EHW98_RS02290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EHW98_RS02295	COG0359	binds to the 23S rRNA
EHW98_RS02300	COG3061	Opacity-associated protein A
EHW98_RS02305	COG0545	Peptidyl-prolyl cis-trans isomerase
EHW98_RS02315	COG1218	3'(2'),5'-bisphosphate nucleotidase
EHW98_RS02325	COG1253	flavin adenine dinucleotide binding
EHW98_RS02330	COG0729	surface antigen
EHW98_RS02340	COG2105	PFAM AIG2 family protein
EHW98_RS02350	COG0840	transmembrane signaling receptor activity
EHW98_RS02355	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EHW98_RS02360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EHW98_RS02365	COG3028	Belongs to the UPF0307 family
EHW98_RS02370	COG0312	modulator of DNA gyrase
EHW98_RS02405	COG3964	amidohydrolase
EHW98_RS02420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW98_RS02420	COG3711	transcriptional antiterminator
EHW98_RS02425	COG2823	Periplasmic or secreted lipoprotein
EHW98_RS02430	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EHW98_RS02435	COG0792	nuclease activity
EHW98_RS02440	COG3107	peptidoglycan biosynthetic process
EHW98_RS02445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EHW98_RS02470	COG1741	Belongs to the pirin family
EHW98_RS02475	COG0583	DNA-binding transcription factor activity
EHW98_RS02485	COG2259	Doxx family
EHW98_RS02495	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
EHW98_RS02500	COG4575	ribosome binding
EHW98_RS02505	COG1422	Protein of unknown function (DUF1090)
EHW98_RS02515	COG0586	Pfam SNARE associated Golgi protein
EHW98_RS02525	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EHW98_RS02530	COG0861	Integral membrane protein TerC family
EHW98_RS02535	COG0038	chloride channel
EHW98_RS02540	COG1063	alcohol dehydrogenase
EHW98_RS02545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHW98_RS02550	COG2223	nitrite transmembrane transporter activity
EHW98_RS02555	COG1451	nucleotide metabolic process
EHW98_RS02560	COG2813	Specifically methylates the guanine in position
EHW98_RS02565	COG1902	pentaerythritol trinitrate reductase activity
EHW98_RS02565	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHW98_RS02575	COG0288	reversible hydration of carbon dioxide
EHW98_RS02580	COG0659	secondary active sulfate transmembrane transporter activity
EHW98_RS02595	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EHW98_RS02600	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EHW98_RS02610	COG0535	radical SAM domain protein
EHW98_RS02635	COG3731	PTS system glucitol sorbitol-specific IIA component
EHW98_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
EHW98_RS02645	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW98_RS02650	COG1349	DNA-binding transcription factor activity
EHW98_RS02655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EHW98_RS02655	COG0517	IMP dehydrogenase activity
EHW98_RS02745	COG0477	Major facilitator Superfamily
EHW98_RS02750	COG1609	Transcriptional regulator
EHW98_RS02775	COG3706	GGDEF domain
EHW98_RS02800	COG2813	Specifically methylates the guanine in position
EHW98_RS02805	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
EHW98_RS02810	COG0456	acetyltransferase
EHW98_RS02815	COG1011	Hydrolase
EHW98_RS02935	COG3501	Rhs element vgr protein
EHW98_RS02955	COG3501	Rhs element vgr protein
EHW98_RS02965	COG3209	COG3209 Rhs family protein
EHW98_RS03000	COG1397	ADP-ribosylglycohydrolase
EHW98_RS03005	COG2818	Glycosylase
EHW98_RS03010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EHW98_RS03010	COG2755	lipolytic protein G-D-S-L family
EHW98_RS03015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EHW98_RS03020	COG2823	Periplasmic or secreted lipoprotein
EHW98_RS03025	COG5487	UPF0391 membrane protein
EHW98_RS03030	COG4667	esterase of the alpha-beta hydrolase superfamily
EHW98_RS03035	COG0084	hydrolase, TatD family'
EHW98_RS03040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EHW98_RS03045	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EHW98_RS03050	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EHW98_RS03055	COG0813	purine-nucleoside phosphorylase activity
EHW98_RS03060	COG3550	peptidyl-serine autophosphorylation
EHW98_RS03065	COG3726	membrane protein affecting hemolysin expression
EHW98_RS03070	COG0560	Phosphoserine phosphatase
EHW98_RS03095	COG0604	alcohol dehydrogenase
EHW98_RS03100	COG0583	DNA-binding transcription factor activity
EHW98_RS03105	COG0488	(ABC) transporter
EHW98_RS03115	COG1349	DNA-binding transcription factor activity
EHW98_RS03125	COG0741	lytic transglycosylase activity
EHW98_RS03130	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EHW98_RS03135	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EHW98_RS03140	COG0406	alpha-ribazole phosphatase activity
EHW98_RS03150	COG3708	Transcriptional regulator
EHW98_RS03150	COG2207	Transcriptional regulator
EHW98_RS03155	COG3045	CreA protein
EHW98_RS03160	COG0745	RESPONSE REGULATOR receiver
EHW98_RS03175	COG0083	homoserine kinase activity
EHW98_RS03185	COG3022	response to hydroperoxide
EHW98_RS03195	COG0521	Mo-molybdopterin cofactor biosynthetic process
EHW98_RS03205	COG0443	Heat shock 70 kDa protein
EHW98_RS03210	COG0484	heat shock protein binding
EHW98_RS03215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHW98_RS03220	COG0268	Binds directly to 16S ribosomal RNA
EHW98_RS03225	COG0196	riboflavin kinase activity
EHW98_RS03230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EHW98_RS03235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EHW98_RS03240	COG1047	Peptidyl-prolyl cis-trans
EHW98_RS03245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EHW98_RS03250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EHW98_RS03255	COG0505	Belongs to the CarA family
EHW98_RS03265	COG1280	lysine exporter protein (LysE YggA)
EHW98_RS03270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EHW98_RS03275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EHW98_RS03280	COG2967	ApaG domain
EHW98_RS03285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EHW98_RS03290	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EHW98_RS03305	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EHW98_RS03310	COG0564	pseudouridine synthase activity
EHW98_RS03315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHW98_RS03320	COG0417	DNA replication proofreading
EHW98_RS03325	COG0586	Pfam SNARE associated Golgi protein
EHW98_RS03330	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EHW98_RS03335	COG1178	ABC-type Fe3 transport system permease component
EHW98_RS03340	COG4143	(ABC) transporter
EHW98_RS03345	COG4533	DNA binding
EHW98_RS03350	COG2814	Major facilitator Superfamily
EHW98_RS03355	COG0066	3-isopropylmalate dehydratase activity
EHW98_RS03365	COG0473	3-isopropylmalate dehydrogenase activity
EHW98_RS03370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHW98_RS03380	COG0028	Belongs to the TPP enzyme family
EHW98_RS03395	COG2001	Belongs to the MraZ family
EHW98_RS03400	COG0275	rRNA processing
EHW98_RS03405	COG3116	cell division
EHW98_RS03410	COG0768	penicillin binding
EHW98_RS03415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EHW98_RS03420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EHW98_RS03425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EHW98_RS03435	COG0772	Belongs to the SEDS family
EHW98_RS03440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EHW98_RS03450	COG1181	Belongs to the D-alanine--D-alanine ligase family
EHW98_RS03460	COG0849	cell division
EHW98_RS03465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EHW98_RS03470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EHW98_RS03485	COG0653	protein targeting
EHW98_RS03495	COG3397	chitin binding
EHW98_RS03570	COG0494	nUDIX hydrolase
EHW98_RS03575	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EHW98_RS03580	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EHW98_RS03590	COG0516	GMP reductase activity
EHW98_RS03595	COG1459	type II secretion system
EHW98_RS03600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHW98_RS03605	COG4969	Belongs to the N-Me-Phe pilin family
EHW98_RS03620	COG3725	Membrane protein required for beta-lactamase induction
EHW98_RS03645	COG3940	Belongs to the glycosyl hydrolase 43 family
EHW98_RS03650	COG2211	Major facilitator Superfamily
EHW98_RS03655	COG1113	amino acid transport
EHW98_RS03660	COG2186	Transcriptional regulator
EHW98_RS03665	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EHW98_RS03670	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW98_RS03675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHW98_RS03680	COG1028	Short-chain dehydrogenase reductase Sdr
EHW98_RS03685	COG1122	ATPase activity
EHW98_RS03690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EHW98_RS03695	COG1268	BioY protein
EHW98_RS03710	COG0318	PFAM AMP-dependent synthetase and ligase
EHW98_RS03715	COG0183	Belongs to the thiolase family
EHW98_RS03720	COG1024	Enoyl-CoA hydratase
EHW98_RS03725	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EHW98_RS03735	COG2175	clavaminate synthase activity
EHW98_RS03740	COG1203	CRISPR-associated helicase, Cas3
EHW98_RS03755	COG1857	crispr-associated protein
EHW98_RS03770	COG1518	maintenance of DNA repeat elements
EHW98_RS03775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHW98_RS03795	COG3112	Uncharacterised protein family (UPF0231)
EHW98_RS03800	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EHW98_RS03805	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EHW98_RS03835	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EHW98_RS03840	COG0288	reversible hydration of carbon dioxide
EHW98_RS03845	COG1131	(ABC) transporter
EHW98_RS03850	COG0842	Transport permease protein
EHW98_RS03855	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EHW98_RS03860	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EHW98_RS03865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EHW98_RS03870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EHW98_RS03890	COG1489	DNA binding
EHW98_RS03895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EHW98_RS03900	COG1643	Atp-dependent helicase
EHW98_RS03905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHW98_RS03915	COG3209	COG3209 Rhs family protein
EHW98_RS03915	COG4104	PAAR repeat-containing protein
EHW98_RS03930	COG3077	Addiction module antitoxin, RelB DinJ family
EHW98_RS03935	COG2026	Addiction module toxin, RelE StbE family
EHW98_RS03950	COG1120	ATPase activity
EHW98_RS03955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHW98_RS03965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EHW98_RS03970	COG0316	Belongs to the HesB IscA family
EHW98_RS03980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHW98_RS03990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHW98_RS04000	COG2171	N-acyltransferase activity
EHW98_RS04005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EHW98_RS04015	COG0052	Belongs to the universal ribosomal protein uS2 family
EHW98_RS04020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EHW98_RS04025	COG0528	UMP kinase activity
EHW98_RS04030	COG0233	cytoplasmic translational termination
EHW98_RS04035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EHW98_RS04040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EHW98_RS04045	COG0575	Belongs to the CDS family
EHW98_RS04050	COG0750	zinc metalloprotease
EHW98_RS04055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW98_RS04060	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EHW98_RS04065	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHW98_RS04070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHW98_RS04075	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHW98_RS04080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHW98_RS04085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EHW98_RS04095	COG0825	malonyl-CoA metabolic process
EHW98_RS04105	COG0346	lactoylglutathione lyase activity
EHW98_RS04110	COG0037	tRNA processing
EHW98_RS04120	COG4568	rho-dependent transcription termination
EHW98_RS04145	COG0442	prolyl-tRNA aminoacylation
EHW98_RS04150	COG1720	tRNA m6t6A37 methyltransferase activity
EHW98_RS04160	COG1464	Belongs to the NlpA lipoprotein family
EHW98_RS04165	COG2011	ABC-type metal ion transport system permease component
EHW98_RS04170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EHW98_RS04175	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EHW98_RS04205	COG0477	Major facilitator Superfamily
EHW98_RS04210	COG5544	Lipoprotein
EHW98_RS04215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHW98_RS04220	COG1042	CoA-binding domain protein
EHW98_RS04220	COG0045	succinate-CoA ligase (ADP-forming) activity
EHW98_RS04220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW98_RS04230	COG3118	belongs to the thioredoxin family
EHW98_RS04235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHW98_RS04240	COG2814	Major facilitator Superfamily
EHW98_RS04245	COG1566	PFAM secretion protein HlyD family protein
EHW98_RS04250	COG1846	Transcriptional regulator
EHW98_RS04255	COG2814	Major facilitator Superfamily
EHW98_RS04260	COG2113	Glycine betaine
EHW98_RS04265	COG4176	ABC-type proline glycine betaine transport system permease component
EHW98_RS04285	COG1780	Probably involved in ribonucleotide reductase function
EHW98_RS04290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHW98_RS04305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW98_RS04320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EHW98_RS04335	COG0745	RESPONSE REGULATOR receiver
EHW98_RS04345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EHW98_RS04350	COG1677	Flagellar hook-basal body complex protein FliE
EHW98_RS04365	COG1317	bacterial-type flagellum organization
EHW98_RS04370	COG1157	protein secretion by the type III secretion system
EHW98_RS04385	COG1580	Controls the rotational direction of flagella during chemotaxis
EHW98_RS04395	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHW98_RS04400	COG3190	flagellar
EHW98_RS04410	COG1987	bacterial-type flagellum assembly
EHW98_RS04420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHW98_RS04420	COG4797	methyltransferase
EHW98_RS04465	COG3418	PFAM FlgN family protein
EHW98_RS04480	COG1815	bacterial-type flagellum-dependent cell motility
EHW98_RS04510	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EHW98_RS04520	COG1705	Flagellar rod assembly protein muramidase FlgJ
EHW98_RS04520	COG3951	Flagellar rod assembly protein muramidase FlgJ
EHW98_RS04530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHW98_RS04535	COG0840	transmembrane signaling receptor activity
EHW98_RS04565	COG2198	Histidine kinase
EHW98_RS04565	COG0643	Histidine kinase
EHW98_RS04570	COG0835	chemotaxis
EHW98_RS04595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EHW98_RS04600	COG2867	negative regulation of translational initiation
EHW98_RS04605	COG2914	Belongs to the UPF0125 (RnfH) family
EHW98_RS04610	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW98_RS04615	COG0497	DNA recombination
EHW98_RS04620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EHW98_RS04625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EHW98_RS04630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EHW98_RS04635	COG0513	Belongs to the DEAD box helicase family
EHW98_RS04640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EHW98_RS04645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EHW98_RS04650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EHW98_RS04665	COG3026	antisigma factor binding
EHW98_RS04670	COG3086	response to oxidative stress
EHW98_RS04685	COG0481	GTPase activity
EHW98_RS04695	COG0571	ribonuclease III activity
EHW98_RS04705	COG1381	Involved in DNA repair and RecF pathway recombination
EHW98_RS04710	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EHW98_RS04715	COG0736	holo-[acyl-carrier-protein] synthase activity
EHW98_RS04725	COG1737	Transcriptional regulator
EHW98_RS04730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EHW98_RS04735	COG0560	Phosphoserine phosphatase
EHW98_RS04745	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EHW98_RS04750	COG0047	phosphoribosylformylglycinamidine synthase activity
EHW98_RS04750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EHW98_RS04755	COG2205	protein histidine kinase activity
EHW98_RS04760	COG3170	Tfp pilus assembly protein FimV
EHW98_RS04765	COG2204	response regulator
EHW98_RS04770	COG0347	Belongs to the P(II) protein family
EHW98_RS04775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EHW98_RS04780	COG3711	transcriptional antiterminator
EHW98_RS04785	COG0483	inositol monophosphate 1-phosphatase activity
EHW98_RS04795	COG1959	2 iron, 2 sulfur cluster binding
EHW98_RS04800	COG1104	cysteine desulfurase activity
EHW98_RS04805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHW98_RS04815	COG0531	amino acid
EHW98_RS04820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHW98_RS04830	COG3938	Belongs to the proline racemase family
EHW98_RS04845	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHW98_RS04850	COG1012	belongs to the aldehyde dehydrogenase family
EHW98_RS04860	COG2897	thiosulfate sulfurtransferase activity
EHW98_RS04865	COG0105	UTP biosynthetic process
EHW98_RS04870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EHW98_RS04880	COG1426	Protein conserved in bacteria
EHW98_RS04885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EHW98_RS04890	COG0124	histidyl-tRNA synthetase
EHW98_RS04895	COG2976	Protein conserved in bacteria
EHW98_RS04900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW98_RS04905	COG1160	GTP binding
EHW98_RS04915	COG4993	Dehydrogenase
EHW98_RS04930	COG1570	exodeoxyribonuclease VII activity
EHW98_RS04935	COG0517	IMP dehydrogenase activity
EHW98_RS04935	COG0516	GMP reductase activity
EHW98_RS04970	COG3122	Protein conserved in bacteria
EHW98_RS04985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW98_RS04990	COG2271	Major facilitator Superfamily
EHW98_RS04995	COG2239	Acts as a magnesium transporter
EHW98_RS05000	COG2200	EAL domain
EHW98_RS05005	COG0500	methyltransferase
EHW98_RS05015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EHW98_RS05020	COG0573	inorganic phosphate transmembrane transporter activity
EHW98_RS05025	COG0581	inorganic phosphate transmembrane transporter activity
EHW98_RS05030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHW98_RS05035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EHW98_RS05040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EHW98_RS05050	COG2233	PERMEase
EHW98_RS05055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EHW98_RS05060	COG1393	Belongs to the ArsC family
EHW98_RS05070	COG3706	GGDEF domain
EHW98_RS05075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EHW98_RS05080	COG2716	regulation of RNA biosynthetic process
EHW98_RS05085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHW98_RS05090	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EHW98_RS05095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EHW98_RS05100	COG2321	neutral zinc metallopeptidase
EHW98_RS05105	COG1444	tRNA N-acetyltransferase activity
EHW98_RS05120	COG3209	COG3209 Rhs family protein
EHW98_RS05120	COG4104	PAAR repeat-containing protein
EHW98_RS05140	COG4104	PAAR repeat-containing protein
EHW98_RS05140	COG3209	COG3209 Rhs family protein
EHW98_RS05160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHW98_RS05165	COG1393	Belongs to the ArsC family
EHW98_RS05180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW98_RS05185	COG2197	response regulator
EHW98_RS05190	COG3850	Histidine kinase
EHW98_RS05205	COG0494	nUDIX hydrolase
EHW98_RS05210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EHW98_RS05215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EHW98_RS05220	COG0408	coproporphyrinogen oxidase activity
EHW98_RS05225	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHW98_RS05250	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EHW98_RS05255	COG4208	sulfate ABC transporter
EHW98_RS05260	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EHW98_RS05270	COG0745	RESPONSE REGULATOR receiver
EHW98_RS05275	COG2205	protein histidine kinase activity
EHW98_RS05285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHW98_RS05295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EHW98_RS05300	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EHW98_RS05305	COG3115	cell septum assembly
EHW98_RS05310	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EHW98_RS05315	COG3530	Putative quorum-sensing-regulated virulence factor
EHW98_RS05320	COG0385	Bile acid
EHW98_RS05325	COG0583	DNA-binding transcription factor activity
EHW98_RS05370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHW98_RS05375	COG3415	Transposase
EHW98_RS05380	COG2116	formate transmembrane transporter activity
EHW98_RS05395	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EHW98_RS05400	COG1914	H( )-stimulated, divalent metal cation uptake system
EHW98_RS05410	COG0667	Aldo Keto reductase
EHW98_RS05415	COG3961	Belongs to the TPP enzyme family
EHW98_RS05420	COG0837	glucose binding
EHW98_RS05435	COG0436	Aminotransferase
EHW98_RS05475	COG0668	transmembrane transport
EHW98_RS05510	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHW98_RS05515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHW98_RS05520	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHW98_RS05525	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EHW98_RS05530	COG1138	Cytochrome C-type biogenesis protein
EHW98_RS05540	COG4235	cytochrome complex assembly
EHW98_RS05540	COG3088	subunit of a heme lyase
EHW98_RS05545	COG4235	cytochrome complex assembly
EHW98_RS05545	COG3088	subunit of a heme lyase
EHW98_RS05555	COG2067	long-chain fatty acid transport protein
EHW98_RS05570	COG0183	Belongs to the thiolase family
EHW98_RS05575	COG1024	Enoyl-CoA hydratase
EHW98_RS05575	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHW98_RS05580	COG2062	phosphohistidine phosphatase, SixA
EHW98_RS05585	COG2840	Smr protein MutS2
EHW98_RS05595	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EHW98_RS05605	COG0730	response to heat
EHW98_RS05610	COG3101	peptidyl-lysine hydroxylation
EHW98_RS05625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHW98_RS05670	COG2207	Transcriptional regulator
EHW98_RS05680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EHW98_RS05690	COG0586	Pfam SNARE associated Golgi protein
EHW98_RS05705	COG0285	dihydrofolate synthase activity
EHW98_RS05710	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EHW98_RS05715	COG1286	toxin biosynthetic process
EHW98_RS05720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EHW98_RS05725	COG0163	prenyltransferase activity
EHW98_RS05740	COG4160	amino acid transport
EHW98_RS05745	COG4598	ABC transporter
EHW98_RS05750	COG1090	epimerase
EHW98_RS05765	COG1177	transmembrane transport
EHW98_RS05770	COG1176	ABC-type spermidine putrescine transport system, permease component I
EHW98_RS05780	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHW98_RS05790	COG3842	ATPase activity
EHW98_RS05795	COG0857	belongs to the CobB CobQ family
EHW98_RS05795	COG0280	phosphate acetyltransferase
EHW98_RS05800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EHW98_RS05805	COG3092	negative regulation of chromosome organization
EHW98_RS05810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHW98_RS05830	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EHW98_RS05835	COG0436	Aminotransferase
EHW98_RS05840	COG0583	DNA-binding transcription factor activity
EHW98_RS05845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW98_RS05850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW98_RS05855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW98_RS05855	COG0649	NAD binding
EHW98_RS05865	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EHW98_RS05875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EHW98_RS05880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW98_RS05885	COG0839	Belongs to the complex I subunit 6 family
EHW98_RS05890	COG0713	ATP synthesis coupled electron transport
EHW98_RS05895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EHW98_RS05900	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW98_RS05905	COG1007	ATP synthesis coupled electron transport
EHW98_RS05920	COG2153	protein acetylation
EHW98_RS05925	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EHW98_RS05930	COG4575	ribosome binding
EHW98_RS05945	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EHW98_RS05965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHW98_RS05975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHW98_RS05980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHW98_RS05990	COG0784	Response regulator, receiver
EHW98_RS05990	COG2205	protein histidine kinase activity
EHW98_RS05995	COG2197	response regulator
EHW98_RS06000	COG2198	Histidine kinase
EHW98_RS06000	COG0642	Histidine kinase
EHW98_RS06025	COG3145	DNA-N1-methyladenine dioxygenase activity
EHW98_RS06035	COG2977	Belongs to the P-Pant transferase superfamily
EHW98_RS06095	COG3083	sulfuric ester hydrolase activity
EHW98_RS06100	COG3082	Protein of unknown function (DUF1414)
EHW98_RS06105	COG3081	Nucleoid-associated protein
EHW98_RS06110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EHW98_RS06115	COG1061	Type III restriction enzyme res subunit
EHW98_RS06120	COG1187	pseudouridine synthase activity
EHW98_RS06125	COG2814	Major facilitator Superfamily
EHW98_RS06135	COG4172	Belongs to the ABC transporter superfamily
EHW98_RS06140	COG4239	(ABC) transporter, permease
EHW98_RS06145	COG4174	ABC transporter (Permease)
EHW98_RS06150	COG4166	transmembrane transport
EHW98_RS06155	COG2200	EAL domain
EHW98_RS06160	COG0791	NLP P60 protein
EHW98_RS06165	COG0671	phosphoesterase, PA-phosphatase related
EHW98_RS06170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHW98_RS06180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW98_RS06180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW98_RS06185	COG1105	Belongs to the carbohydrate kinase PfkB family
EHW98_RS06190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHW98_RS06190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHW98_RS06190	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EHW98_RS06195	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EHW98_RS06200	COG2855	membrane
EHW98_RS06205	COG0583	DNA-binding transcription factor activity
EHW98_RS06210	COG0833	amino acid
EHW98_RS06215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW98_RS06220	COG1120	ATPase activity
EHW98_RS06240	COG0583	DNA-binding transcription factor activity
EHW98_RS06245	COG0302	gtp cyclohydrolase
EHW98_RS06250	COG2311	Membrane
EHW98_RS06255	COG1609	Transcriptional regulator
EHW98_RS06265	COG1129	ABC transporter
EHW98_RS06275	COG2949	membrane
EHW98_RS06280	COG0281	malic enzyme
EHW98_RS06285	COG0295	cytidine deaminase activity
EHW98_RS06290	COG1346	cytolysis
EHW98_RS06295	COG1380	Effector of murein hydrolase LrgA
EHW98_RS06300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHW98_RS06300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHW98_RS06305	COG0489	protein tyrosine kinase activity
EHW98_RS06320	COG1605	Chorismate mutase
EHW98_RS06330	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EHW98_RS06335	COG0351	phosphomethylpyrimidine kinase
EHW98_RS06340	COG1597	lipid kinase activity
EHW98_RS06360	COG0745	RESPONSE REGULATOR receiver
EHW98_RS06365	COG2205	protein histidine kinase activity
EHW98_RS06390	COG0443	Heat shock 70 kDa protein
EHW98_RS06395	COG5001	Diguanylate cyclase
EHW98_RS06395	COG3447	MASE1 domain protein
EHW98_RS06395	COG5002	protein histidine kinase activity
EHW98_RS06405	COG0572	uridine kinase
EHW98_RS06410	COG0717	Belongs to the dCTP deaminase family
EHW98_RS06415	COG2982	Protein involved in outer membrane biogenesis
EHW98_RS06420	COG1253	flavin adenine dinucleotide binding
EHW98_RS06485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EHW98_RS06520	COG1442	glycosyl transferase family 8
EHW98_RS06550	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EHW98_RS06555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EHW98_RS06555	COG0140	phosphoribosyl-ATP diphosphatase activity
EHW98_RS06565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EHW98_RS06570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EHW98_RS06575	COG0131	Imidazoleglycerol-phosphate dehydratase
EHW98_RS06575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EHW98_RS06580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EHW98_RS06590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EHW98_RS06600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW98_RS06605	COG0531	amino acid
EHW98_RS06610	COG2925	Exonuclease
EHW98_RS06615	COG1289	transmembrane transporter activity
EHW98_RS06620	COG2926	Belongs to the UPF0265 family
EHW98_RS06625	COG0534	Mate efflux family protein
EHW98_RS06635	COG0596	Alpha beta hydrolase
EHW98_RS06640	COG1280	lysine exporter protein (LysE YggA)
EHW98_RS06655	COG0077	Prephenate dehydratase
EHW98_RS06660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EHW98_RS06680	COG1522	sequence-specific DNA binding
EHW98_RS06690	COG3284	Transcriptional regulator
EHW98_RS06695	COG1063	alcohol dehydrogenase
EHW98_RS06700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHW98_RS06740	COG0583	DNA-binding transcription factor activity
EHW98_RS06745	COG1280	lysine exporter protein (LysE YggA)
EHW98_RS06790	COG0747	negative chemotaxis
EHW98_RS06795	COG0601	transmembrane transport
EHW98_RS06800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW98_RS06805	COG4172	Belongs to the ABC transporter superfamily
EHW98_RS06815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW98_RS06845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHW98_RS06850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHW98_RS06855	COG1121	(ABC) transporter
EHW98_RS06860	COG0803	Belongs to the bacterial solute-binding protein 9 family
EHW98_RS06865	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EHW98_RS06875	COG3228	Belongs to the MtfA family
EHW98_RS06885	COG1418	mRNA catabolic process
EHW98_RS06890	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EHW98_RS06900	COG3727	T/G mismatch-specific endonuclease activity
EHW98_RS06910	COG2354	Protein conserved in bacteria
EHW98_RS06915	COG5475	Uncharacterized small protein (DUF2158)
EHW98_RS06930	COG0366	Alpha amylase catalytic
EHW98_RS06940	COG1516	flagellar protein fliS
EHW98_RS06945	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EHW98_RS06950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHW98_RS06950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHW98_RS06975	COG4763	Acyl-transferase
EHW98_RS06980	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EHW98_RS06980	COG0506	proline dehydrogenase activity
EHW98_RS06980	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EHW98_RS07005	COG1702	phosphate starvation-inducible protein PhoH
EHW98_RS07020	COG0778	Nitroreductase
EHW98_RS07045	COG3381	protein complex oligomerization
EHW98_RS07055	COG1012	belongs to the aldehyde dehydrogenase family
EHW98_RS07060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EHW98_RS07065	COG1216	Glycosyl transferase, family 2
EHW98_RS07070	COG2244	polysaccharide biosynthetic process
EHW98_RS07080	COG0431	NADPH-dependent FMN reductase
EHW98_RS07085	COG0113	porphobilinogen synthase activity
EHW98_RS07140	COG0835	chemotaxis
EHW98_RS07160	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EHW98_RS07170	COG0745	RESPONSE REGULATOR receiver
EHW98_RS07180	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EHW98_RS07195	COG0018	arginyl-trna synthetase
EHW98_RS07200	COG3102	Protein conserved in bacteria
EHW98_RS07205	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EHW98_RS07210	COG3142	Participates in the control of copper homeostasis
EHW98_RS07220	COG0500	methyltransferase
EHW98_RS07225	COG2226	methyltransferase
EHW98_RS07230	COG3788	relative of glutathione S-transferase, MAPEG superfamily
EHW98_RS07235	COG1801	Protein of unknown function DUF72
EHW98_RS07240	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EHW98_RS07245	COG0494	nUDIX hydrolase
EHW98_RS07250	COG0217	transcriptional regulatory protein
EHW98_RS07255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EHW98_RS07260	COG0632	four-way junction helicase activity
EHW98_RS07265	COG2255	four-way junction helicase activity
EHW98_RS07270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHW98_RS07280	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EHW98_RS07285	COG0739	heme binding
EHW98_RS07290	COG1560	Kdo2-lipid A biosynthetic process
EHW98_RS07300	COG0469	pyruvate kinase activity
EHW98_RS07305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EHW98_RS07310	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EHW98_RS07315	COG3141	response to X-ray
EHW98_RS07320	COG1082	Xylose isomerase domain protein TIM barrel
EHW98_RS07325	COG1770	oligopeptidase
EHW98_RS07330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHW98_RS07380	COG0628	permease
EHW98_RS07395	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EHW98_RS07395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EHW98_RS07400	COG3008	intermembrane lipid transfer
EHW98_RS07405	COG2995	paraquat-inducible protein a
EHW98_RS07410	COG1956	GAF domain-containing protein
EHW98_RS07415	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EHW98_RS07425	COG0501	Belongs to the peptidase M48B family
EHW98_RS07455	COG2226	methyltransferase
EHW98_RS07460	COG1253	flavin adenine dinucleotide binding
EHW98_RS07465	COG1760	l-serine dehydratase
EHW98_RS07480	COG3140	Belongs to the UPF0181 family
EHW98_RS07485	COG0251	oxidation-reduction process
EHW98_RS07490	COG1199	ATP-dependent helicase activity
EHW98_RS07500	COG3065	identical protein binding
EHW98_RS07505	COG0318	PFAM AMP-dependent synthetase and ligase
EHW98_RS07515	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EHW98_RS07520	COG2894	cell division
EHW98_RS07525	COG0850	regulation of cytokinetic process
EHW98_RS07530	COG3100	YcgL domain-containing protein
EHW98_RS07535	COG0179	Fumarylacetoacetate (FAA) hydrolase
EHW98_RS07550	COG2186	Transcriptional regulator
EHW98_RS07555	COG2719	SpoVR family
EHW98_RS07560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHW98_RS07565	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHW98_RS07590	COG2718	Belongs to the UPF0229 family
EHW98_RS07595	COG2766	serine protein kinase
EHW98_RS07600	COG3713	MltA-interacting MipA family protein
EHW98_RS07605	COG0656	L-ascorbic acid biosynthetic process
EHW98_RS07620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHW98_RS07625	COG3139	Protein of unknown function (DUF1315)
EHW98_RS07630	COG1335	isochorismatase
EHW98_RS07635	COG0252	asparaginase activity
EHW98_RS07640	COG0616	signal peptide processing
EHW98_RS07645	COG0778	Nitroreductase
EHW98_RS07660	COG0708	Exodeoxyribonuclease III
EHW98_RS07695	COG0788	formyltetrahydrofolate deformylase activity
EHW98_RS07700	COG3012	SEC-C Motif Domain Protein
EHW98_RS07705	COG0745	RESPONSE REGULATOR receiver
EHW98_RS07710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EHW98_RS07760	COG2828	Protein conserved in bacteria
EHW98_RS07765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHW98_RS07770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EHW98_RS07775	COG0583	DNA-binding transcription factor activity
EHW98_RS07780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EHW98_RS07790	COG3384	dioxygenase
EHW98_RS07805	COG2095	MarC family integral membrane protein
EHW98_RS07810	COG4166	transmembrane transport
EHW98_RS07820	COG0601	transmembrane transport
EHW98_RS07825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW98_RS07830	COG0444	Belongs to the ABC transporter superfamily
EHW98_RS07840	COG3099	Belongs to the UPF0263 family
EHW98_RS07845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHW98_RS07860	COG2350	Protein conserved in bacteria
EHW98_RS07875	COG2917	probably involved in intracellular septation
EHW98_RS07885	COG3047	cAMP biosynthetic process
EHW98_RS07895	COG0159	tryptophan synthase activity
EHW98_RS07900	COG0133	tryptophan synthase activity
EHW98_RS07910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHW98_RS07915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHW98_RS07915	COG0512	Glutamine amidotransferase of anthranilate synthase
EHW98_RS07925	COG0613	PHP domain protein
EHW98_RS07930	COG0009	L-threonylcarbamoyladenylate synthase
EHW98_RS07940	COG1028	Short-chain dehydrogenase reductase Sdr
EHW98_RS07945	COG0616	signal peptide processing
EHW98_RS07970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EHW98_RS07980	COG0671	phosphoesterase, PA-phosphatase related
EHW98_RS07985	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EHW98_RS07990	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EHW98_RS07995	COG0284	orotidine-5'-phosphate decarboxylase activity
EHW98_RS08000	COG0023	Translation Initiation Factor
EHW98_RS08015	COG0235	Class ii aldolase
EHW98_RS08020	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EHW98_RS08055	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHW98_RS08055	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHW98_RS08065	COG4172	Belongs to the ABC transporter superfamily
EHW98_RS08070	COG4172	Belongs to the ABC transporter superfamily
EHW98_RS08075	COG4171	peptide transport system, permease
EHW98_RS08080	COG4168	peptide transport system, permease
EHW98_RS08090	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EHW98_RS08095	COG1842	Phage shock protein A
EHW98_RS08105	COG1983	PspC domain protein
EHW98_RS08115	COG3106	COG3106 Predicted ATPase
EHW98_RS08120	COG3768	UPF0283 membrane protein
EHW98_RS08135	COG4948	Mandelate Racemase Muconate Lactonizing
EHW98_RS08140	COG4166	transmembrane transport
EHW98_RS08160	COG3188	usher protein
EHW98_RS08165	COG3121	Chaperone
EHW98_RS08170	COG3539	Fimbrial protein
EHW98_RS08180	COG0366	Alpha amylase catalytic
EHW98_RS08185	COG0037	tRNA processing
EHW98_RS08190	COG0513	Belongs to the DEAD box helicase family
EHW98_RS08205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHW98_RS08210	COG2911	Protein conserved in bacteria
EHW98_RS08220	COG3784	Protein of unknown function (DUF1318)
EHW98_RS08225	COG1028	Short-chain dehydrogenase reductase Sdr
EHW98_RS08230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EHW98_RS08235	COG1643	Atp-dependent helicase
EHW98_RS08240	COG3023	N-Acetylmuramoyl-L-alanine amidase
EHW98_RS08245	COG3591	Belongs to the peptidase S1B family
EHW98_RS08255	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EHW98_RS08260	COG2205	protein histidine kinase activity
EHW98_RS08265	COG0582	viral genome integration into host DNA
EHW98_RS08305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EHW98_RS08320	COG0745	RESPONSE REGULATOR receiver
EHW98_RS08330	COG0531	amino acid
EHW98_RS08345	COG3182	Iron-regulated membrane protein
EHW98_RS08370	COG2840	Smr protein MutS2
EHW98_RS08390	COG2814	Major facilitator Superfamily
EHW98_RS08410	COG2195	Cleaves the N-terminal amino acid of tripeptides
EHW98_RS08415	COG0747	negative chemotaxis
EHW98_RS08425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW98_RS08455	COG2814	Major facilitator Superfamily
EHW98_RS08465	COG2207	Transcriptional regulator
EHW98_RS08465	COG3708	Transcriptional regulator
EHW98_RS08480	COG4290	ribonuclease
EHW98_RS08500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW98_RS08540	COG0840	transmembrane signaling receptor activity
EHW98_RS08590	COG1309	transcriptional regulator
EHW98_RS08605	COG1629	transport
EHW98_RS08605	COG4771	TonB-dependent receptor
EHW98_RS08605	COG1629	transport
EHW98_RS08605	COG4771	TonB-dependent receptor
EHW98_RS08615	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EHW98_RS08620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EHW98_RS08630	COG2707	UPF0756 membrane protein
EHW98_RS08645	COG0339	signal peptide processing
EHW98_RS08650	COG0402	S-adenosylhomocysteine deaminase activity
EHW98_RS08655	COG4221	oxidoreductase activity
EHW98_RS08670	COG0477	Major facilitator Superfamily
EHW98_RS08680	COG1940	carbohydrate kinase activity
EHW98_RS08685	COG0583	DNA-binding transcription factor activity
EHW98_RS08690	COG2814	Major facilitator Superfamily
EHW98_RS08710	COG5339	Protein conserved in bacteria
EHW98_RS08715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EHW98_RS08720	COG0673	inositol 2-dehydrogenase activity
EHW98_RS08730	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW98_RS08740	COG1879	ABC-type sugar transport system periplasmic component
EHW98_RS08745	COG1069	ribulokinase activity
EHW98_RS08750	COG2160	L-arabinose isomerase activity
EHW98_RS08760	COG4657	Part of a membrane complex involved in electron transport
EHW98_RS08765	COG2878	Part of a membrane complex involved in electron transport
EHW98_RS08770	COG4656	Part of a membrane complex involved in electron transport
EHW98_RS08775	COG4658	electron transport chain
EHW98_RS08780	COG4659	FMN binding
EHW98_RS08785	COG4660	Part of a membrane complex involved in electron transport
EHW98_RS08790	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EHW98_RS08805	COG1309	transcriptional regulator
EHW98_RS08815	COG0625	glutathione transferase activity
EHW98_RS08825	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EHW98_RS08830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EHW98_RS08835	COG0259	pyridoxamine-phosphate oxidase activity
EHW98_RS08840	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EHW98_RS08860	COG3313	Fe-S protein
EHW98_RS08880	COG2194	sulfuric ester hydrolase activity
EHW98_RS08890	COG1902	pentaerythritol trinitrate reductase activity
EHW98_RS08895	COG0346	lactoylglutathione lyase activity
EHW98_RS08905	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EHW98_RS08910	COG0791	NLP P60 protein
EHW98_RS08915	COG1609	Transcriptional regulator
EHW98_RS08920	COG0583	DNA-binding transcription factor activity
EHW98_RS08925	COG2814	Major facilitator Superfamily
EHW98_RS08930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHW98_RS08935	COG0307	riboflavin synthase, alpha
EHW98_RS08955	COG0469	pyruvate kinase activity
EHW98_RS08965	COG2166	iron-sulfur cluster assembly
EHW98_RS08975	COG0719	Fe-S assembly protein
EHW98_RS08980	COG0396	ATPase activity
EHW98_RS08985	COG0719	Fe-S assembly protein
EHW98_RS08990	COG0316	Belongs to the HesB IscA family
EHW98_RS09000	COG0277	FAD linked oxidase domain protein
EHW98_RS09000	COG0247	lactate metabolic process
EHW98_RS09005	COG0628	permease
EHW98_RS09015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHW98_RS09015	COG0574	Belongs to the PEP-utilizing enzyme family
EHW98_RS09020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EHW98_RS09030	COG3720	iron ion transport
EHW98_RS09035	COG4558	Periplasmic binding protein
EHW98_RS09040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW98_RS09045	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EHW98_RS09050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EHW98_RS09060	COG0791	NLP P60 protein
EHW98_RS09065	COG0386	Belongs to the glutathione peroxidase family
EHW98_RS09075	COG0776	regulation of translation
EHW98_RS09085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EHW98_RS09095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EHW98_RS09100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EHW98_RS09110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EHW98_RS09115	COG3137	Salt-induced outer membrane protein
EHW98_RS09125	COG3001	Fructosamine kinase
EHW98_RS09135	COG1988	membrane-bound metal-dependent
EHW98_RS09150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW98_RS09155	COG2814	Major facilitator Superfamily
EHW98_RS09160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EHW98_RS09165	COG0322	excinuclease ABC activity
EHW98_RS09170	COG3678	ATP-independent chaperone mediated protein folding
EHW98_RS09175	COG2988	succinylglutamate desuccinylase activity
EHW98_RS09180	COG3724	N-succinylarginine dihydrolase activity
EHW98_RS09185	COG1012	belongs to the aldehyde dehydrogenase family
EHW98_RS09200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHW98_RS09205	COG4932	domain protein
EHW98_RS09235	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EHW98_RS09265	COG0387	Pfam Sodium calcium exchanger
EHW98_RS09270	COG3187	Heat shock protein
EHW98_RS09275	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EHW98_RS09280	COG2912	Transglutaminase-like superfamily
EHW98_RS09290	COG2890	protein-(glutamine-N5) methyltransferase activity
EHW98_RS09295	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EHW98_RS09300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EHW98_RS09305	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EHW98_RS09310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EHW98_RS09325	COG0193	aminoacyl-tRNA hydrolase activity
EHW98_RS09335	COG0659	secondary active sulfate transmembrane transporter activity
EHW98_RS09340	COG0012	GTP binding
EHW98_RS09350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHW98_RS09500	COG3290	protein histidine kinase activity
EHW98_RS09505	COG4565	transcriptional regulatory protein
EHW98_RS09525	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EHW98_RS09525	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EHW98_RS09540	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EHW98_RS09550	COG2261	transglycosylase associated protein
EHW98_RS09555	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EHW98_RS09560	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EHW98_RS09570	COG1619	proteins homologs of microcin C7 resistance protein MccF
EHW98_RS09610	COG0538	isocitrate dehydrogenase activity
EHW98_RS09630	COG2915	High frequency lysogenization protein hflD homolog
EHW98_RS09635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EHW98_RS09640	COG0745	RESPONSE REGULATOR receiver
EHW98_RS09650	COG2850	peptidyl-arginine hydroxylation
EHW98_RS09655	COG1396	sequence-specific DNA binding
EHW98_RS09660	COG3135	benzoate transporter
EHW98_RS09670	COG1940	carbohydrate kinase activity
EHW98_RS09680	COG4591	ABC-type transport system involved in lipoprotein release permease component
EHW98_RS09690	COG4591	ABC-type transport system involved in lipoprotein release permease component
EHW98_RS09695	COG2199	diguanylate cyclase activity
EHW98_RS09715	COG0835	chemotaxis
EHW98_RS09715	COG0784	Response regulator, receiver
EHW98_RS09720	COG1677	Flagellar hook-basal body complex protein FliE
EHW98_RS09730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHW98_RS09735	COG1317	bacterial-type flagellum organization
EHW98_RS09755	COG1580	Controls the rotational direction of flagella during chemotaxis
EHW98_RS09760	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHW98_RS09810	COG1215	transferase activity, transferring glycosyl groups
EHW98_RS09815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EHW98_RS09820	COG3134	Outer membrane lipoprotein
EHW98_RS09825	COG1252	NADH dehydrogenase
EHW98_RS09835	COG1472	Belongs to the glycosyl hydrolase 3 family
EHW98_RS09845	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
EHW98_RS09855	COG0537	adenosine 5'-monophosphoramidase activity
EHW98_RS09860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHW98_RS09860	COG1263	PTS System
EHW98_RS09865	COG0084	hydrolase, TatD family'
EHW98_RS09870	COG0470	DNA polymerase III
EHW98_RS09875	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EHW98_RS09880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EHW98_RS09885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EHW98_RS09890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHW98_RS09895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHW98_RS09905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EHW98_RS09910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EHW98_RS09915	COG0416	fatty acid biosynthetic process
EHW98_RS09920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EHW98_RS09925	COG1399	metal-binding, possibly nucleic acid-binding protein
EHW98_RS09930	COG0424	maF-like protein
EHW98_RS09935	COG0564	pseudouridine synthase activity
EHW98_RS09940	COG1530	ribonuclease E activity
EHW98_RS09940	COG1530	ribonuclease E activity
EHW98_RS09945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHW98_RS09950	COG1256	bacterial-type flagellum assembly
EHW98_RS09980	COG1749	Flagellar hook protein flgE
EHW98_RS09985	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EHW98_RS09990	COG1558	bacterial-type flagellum-dependent cell motility
EHW98_RS09995	COG1815	bacterial-type flagellum-dependent cell motility
EHW98_RS10010	COG3418	PFAM FlgN family protein
EHW98_RS10025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW98_RS10030	COG2999	glutathione oxidoreductase activity
EHW98_RS10040	COG0418	dihydroorotase activity
EHW98_RS10060	COG3038	cytochrome b561
EHW98_RS10075	COG1560	Kdo2-lipid A biosynthetic process
EHW98_RS10085	COG5645	(Lipo)protein
EHW98_RS10105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHW98_RS10135	COG1846	Transcriptional regulator
EHW98_RS10160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EHW98_RS10165	COG0322	excinuclease ABC activity
EHW98_RS10170	COG2197	response regulator
EHW98_RS10180	COG3136	membrane protein required for alginate biosynthesis
EHW98_RS10190	COG2197	response regulator
EHW98_RS10195	COG1113	amino acid transport
EHW98_RS10205	COG1309	transcriptional regulator
EHW98_RS10220	COG1012	belongs to the aldehyde dehydrogenase family
EHW98_RS10245	COG0670	Belongs to the BI1 family
EHW98_RS10250	COG2920	part of a sulfur-relay system
EHW98_RS10260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHW98_RS10265	COG3785	DNA binding
EHW98_RS10275	COG1803	Methylglyoxal synthase
EHW98_RS10280	COG0210	DNA helicase
EHW98_RS10285	COG3304	Inner membrane component domain
EHW98_RS10290	COG1289	transmembrane transporter activity
EHW98_RS10295	COG3070	regulator of competence-specific genes
EHW98_RS10305	COG2885	chlorophyll binding
EHW98_RS10305	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EHW98_RS10310	COG3120	sequence-specific DNA binding
EHW98_RS10315	COG1067	ATP-dependent peptidase activity
EHW98_RS10320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHW98_RS10325	COG3130	regulation of translation
EHW98_RS10330	COG3009	Protein conserved in bacteria
EHW98_RS10335	COG3008	intermembrane lipid transfer
EHW98_RS10335	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHW98_RS10340	COG2995	paraquat-inducible protein a
EHW98_RS10345	COG0488	(ABC) transporter
EHW98_RS10350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHW98_RS10350	COG0116	Belongs to the methyltransferase superfamily
EHW98_RS10355	COG3217	Mosc domain protein beta barrel domain protein
EHW98_RS10355	COG0633	Ferredoxin
EHW98_RS10365	COG0167	dihydroorotate dehydrogenase activity
EHW98_RS10370	COG0431	NADPH-dependent FMN reductase
EHW98_RS10375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHW98_RS10385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW98_RS10395	COG0308	aminopeptidase N
EHW98_RS10400	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EHW98_RS10405	COG0017	Asparaginyl-tRNA synthetase
EHW98_RS10415	COG1448	Aminotransferase
EHW98_RS10420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHW98_RS10425	COG3108	Peptidase M15
EHW98_RS10430	COG2989	Protein conserved in bacteria
EHW98_RS10435	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EHW98_RS10440	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EHW98_RS10445	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EHW98_RS10450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHW98_RS10455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EHW98_RS10460	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EHW98_RS10465	COG2835	tetraacyldisaccharide 4'-kinase activity
EHW98_RS10470	COG1663	tetraacyldisaccharide 4'-kinase activity
EHW98_RS10480	COG0658	competence protein
EHW98_RS10480	COG2333	competence protein COMEC
EHW98_RS10485	COG0776	regulation of translation
EHW98_RS10490	COG0539	negative regulation of cytoplasmic translation
EHW98_RS10495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EHW98_RS10500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EHW98_RS10505	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EHW98_RS10510	COG1944	ATP diphosphatase activity
EHW98_RS10520	COG0477	Major facilitator Superfamily
EHW98_RS10525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EHW98_RS10530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EHW98_RS10535	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EHW98_RS10540	COG1674	ftsk spoiiie
EHW98_RS10540	COG3107	peptidoglycan biosynthetic process
EHW98_RS10550	COG0492	ferredoxin-NADP+ reductase activity
EHW98_RS10555	COG4988	ABC transporter
EHW98_RS10560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EHW98_RS10565	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EHW98_RS10570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EHW98_RS10575	COG0542	response to heat
EHW98_RS10580	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EHW98_RS10590	COG1278	Cold shock
EHW98_RS10595	COG3593	DNA synthesis involved in DNA repair
EHW98_RS10600	COG0028	Belongs to the TPP enzyme family
EHW98_RS10605	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EHW98_RS10615	COG3023	N-Acetylmuramoyl-L-alanine amidase
EHW98_RS10620	COG0393	Putative heavy-metal-binding
EHW98_RS10630	COG1126	abc transporter atp-binding protein
EHW98_RS10635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW98_RS10640	COG4215	(ABC) transporter
EHW98_RS10645	COG4160	amino acid transport
EHW98_RS10650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW98_RS10660	COG1177	transmembrane transport
EHW98_RS10665	COG1176	ABC-type spermidine putrescine transport system, permease component I
EHW98_RS10670	COG3842	ATPase activity
EHW98_RS10675	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EHW98_RS10710	COG0814	amino acid
EHW98_RS10715	COG1686	Belongs to the peptidase S11 family
EHW98_RS10735	COG4172	Belongs to the ABC transporter superfamily
EHW98_RS10745	COG0303	'Molybdopterin
EHW98_RS10755	COG0488	(ABC) transporter
EHW98_RS10760	COG2814	Major facilitator Superfamily
EHW98_RS10775	COG2814	Major facilitator Superfamily
EHW98_RS10780	COG1566	PFAM secretion protein HlyD family protein
EHW98_RS10785	COG1321	iron dependent repressor
EHW98_RS10790	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EHW98_RS10800	COG0783	Belongs to the Dps family
EHW98_RS10805	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EHW98_RS10810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW98_RS10815	COG0765	amino acid transport
EHW98_RS10820	COG1126	abc transporter atp-binding protein
EHW98_RS10830	COG0668	transmembrane transport
EHW98_RS10835	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EHW98_RS10845	COG0641	radical SAM
EHW98_RS10860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EHW98_RS10865	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
EHW98_RS10875	COG1228	amidohydrolase
EHW98_RS10880	COG0402	S-adenosylhomocysteine deaminase activity
EHW98_RS10895	COG2986	histidine ammonia-lyase
EHW98_RS10900	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EHW98_RS10905	COG1473	amidohydrolase
EHW98_RS10910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHW98_RS10930	COG0789	Transcriptional regulator
EHW98_RS10940	COG4221	oxidoreductase activity
EHW98_RS10955	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHW98_RS10975	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EHW98_RS10990	COG0277	FAD linked oxidase domain protein
EHW98_RS11000	COG1511	domain protein
EHW98_RS11000	COG3264	Mechanosensitive ion channel
EHW98_RS11005	COG1686	Belongs to the peptidase S11 family
EHW98_RS11015	COG0586	Pfam SNARE associated Golgi protein
EHW98_RS11020	COG3387	PFAM Glycoside hydrolase 15-related
EHW98_RS11025	COG1376	ErfK ybiS ycfS ynhG family protein
EHW98_RS11030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHW98_RS11035	COG0513	Belongs to the DEAD box helicase family
EHW98_RS11045	COG0670	Belongs to the BI1 family
EHW98_RS11060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EHW98_RS11065	COG0315	cyclic pyranopterin monophosphate synthase activity
EHW98_RS11070	COG0521	Mo-molybdopterin cofactor biosynthetic process
EHW98_RS11085	COG0556	nucleotide-excision repair
EHW98_RS11095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EHW98_RS11105	COG0156	8-amino-7-oxononanoate synthase activity
EHW98_RS11110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EHW98_RS11120	COG2130	NADP-dependent
EHW98_RS11125	COG1881	PFAM PEBP family protein
EHW98_RS11130	COG2706	6-phosphogluconolactonase activity
EHW98_RS11135	COG0561	phosphatase activity
EHW98_RS11145	COG4149	molybdate abc transporter
EHW98_RS11150	COG0725	ABC transporter, periplasmic molybdate-binding protein
EHW98_RS11160	COG3585	molybdate ion transport
EHW98_RS11160	COG2005	Transcriptional regulator
EHW98_RS11165	COG1119	ATPase activity
EHW98_RS11175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EHW98_RS11180	COG2017	converts alpha-aldose to the beta-anomer
EHW98_RS11185	COG0588	phosphoglycerate mutase activity
EHW98_RS11205	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHW98_RS11215	COG1230	cation diffusion facilitator family transporter
EHW98_RS11280	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EHW98_RS11285	COG2885	chlorophyll binding
EHW98_RS11290	COG0823	Involved in the tonB-independent uptake of proteins
EHW98_RS11295	COG3064	Membrane
EHW98_RS11300	COG0848	biopolymer transport protein
EHW98_RS11305	COG0811	peptide transport
EHW98_RS11310	COG0824	Thioesterase
EHW98_RS11315	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EHW98_RS11320	COG0045	succinate-CoA ligase (ADP-forming) activity
EHW98_RS11325	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW98_RS11330	COG0567	Dehydrogenase, E1 component
EHW98_RS11335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EHW98_RS11340	COG1053	succinate dehydrogenase
EHW98_RS11345	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EHW98_RS11350	COG2009	succinate dehydrogenase
EHW98_RS11355	COG0372	Belongs to the citrate synthase family
EHW98_RS11365	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EHW98_RS11370	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EHW98_RS11375	COG1984	allophanate hydrolase subunit 2
EHW98_RS11380	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EHW98_RS11390	COG0415	Belongs to the DNA photolyase family
EHW98_RS11395	COG3272	Protein of unknown function (DUF1722)
EHW98_RS11405	COG0745	RESPONSE REGULATOR receiver
EHW98_RS11410	COG0033	Phosphoglucomutase
EHW98_RS11415	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EHW98_RS11420	COG0596	Alpha beta hydrolase
EHW98_RS11435	COG0735	belongs to the Fur family
EHW98_RS11440	COG0814	amino acid
EHW98_RS11445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHW98_RS11455	COG0363	glucosamine-6-phosphate deaminase activity
EHW98_RS11460	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EHW98_RS11465	COG1846	Transcriptional regulator
EHW98_RS11465	COG1940	carbohydrate kinase activity
EHW98_RS11470	COG0647	UMP catabolic process
EHW98_RS11475	COG0367	asparagine synthase
EHW98_RS11510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW98_RS11515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EHW98_RS11520	COG1702	phosphate starvation-inducible protein PhoH
EHW98_RS11525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EHW98_RS11530	COG4535	Mg2 and Co2 transporter CorC
EHW98_RS11535	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EHW98_RS11545	COG0765	amino acid transport
EHW98_RS11550	COG0765	amino acid transport
EHW98_RS11555	COG1126	abc transporter atp-binding protein
EHW98_RS11560	COG2888	peptidyl-tyrosine sulfation
EHW98_RS11565	COG0495	leucyl-tRNA aminoacylation
EHW98_RS11570	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EHW98_RS11575	COG1466	dna polymerase III delta subunit
EHW98_RS11585	COG0799	negative regulation of ribosome biogenesis
EHW98_RS11590	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EHW98_RS11595	COG0768	penicillin binding
EHW98_RS11600	COG0772	Belongs to the SEDS family
EHW98_RS11605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EHW98_RS11610	COG1686	Belongs to the peptidase S11 family
EHW98_RS11615	COG2921	Belongs to the UPF0250 family
EHW98_RS11620	COG0321	lipoyl(octanoyl) transferase activity
EHW98_RS11625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EHW98_RS11630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHW98_RS11635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHW98_RS11650	COG2610	gluconate transmembrane transporter activity
EHW98_RS11655	COG2610	gluconate transmembrane transporter activity
EHW98_RS11660	COG3622	Belongs to the hyi family
EHW98_RS11665	COG0235	Class ii aldolase
EHW98_RS11670	COG3395	kinase activity
EHW98_RS11675	COG2084	Dehydrogenase
EHW98_RS11680	COG1349	DNA-binding transcription factor activity
EHW98_RS11695	COG1271	oxidase subunit
EHW98_RS11700	COG1294	oxidase, subunit
EHW98_RS11710	COG2076	Multidrug Resistance protein
EHW98_RS11715	COG2076	Multidrug Resistance protein
EHW98_RS11720	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EHW98_RS11725	COG0726	polysaccharide deacetylase
EHW98_RS11730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW98_RS11730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHW98_RS11735	COG0463	Glycosyl transferase, family 2
EHW98_RS11740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHW98_RS11750	COG4993	Dehydrogenase
EHW98_RS11755	COG4772	TonB-dependent receptor
EHW98_RS11770	COG4172	Belongs to the ABC transporter superfamily
EHW98_RS11790	COG0646	methionine synthase
EHW98_RS11790	COG1410	methionine synthase
EHW98_RS11805	COG1764	response to oxidative stress
EHW98_RS11830	COG0582	viral genome integration into host DNA
EHW98_RS11840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EHW98_RS11845	COG2501	S4 domain
EHW98_RS11850	COG1064	alcohol dehydrogenase
EHW98_RS11855	COG0215	cysteine-tRNA ligase activity
EHW98_RS11860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHW98_RS11870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EHW98_RS11875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EHW98_RS11880	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EHW98_RS11885	COG4181	ATPase activity
EHW98_RS11890	COG2755	lipolytic protein G-D-S-L family
EHW98_RS11915	COG0300	oxidoreductase activity
EHW98_RS11920	COG3118	belongs to the thioredoxin family
EHW98_RS11925	COG0330	HflC and HflK could
EHW98_RS11930	COG1585	Membrane protein implicated in regulation of membrane protease activity
EHW98_RS11940	COG2217	Heavy metal translocating P-type atpase
EHW98_RS11945	COG3735	TraB family
EHW98_RS11950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EHW98_RS11955	COG0583	DNA-binding transcription factor activity
EHW98_RS11965	COG0737	Belongs to the 5'-nucleotidase family
EHW98_RS11970	COG2223	nitrite transmembrane transporter activity
EHW98_RS11975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EHW98_RS11975	COG4651	solute:proton antiporter activity
EHW98_RS11985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW98_RS11990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EHW98_RS11995	COG0563	adenylate kinase activity
EHW98_RS12020	COG0583	DNA-binding transcription factor activity
EHW98_RS12025	COG0326	Molecular chaperone. Has ATPase activity
EHW98_RS12030	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EHW98_RS12035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EHW98_RS12045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EHW98_RS12050	COG2832	Protein of unknown function (DUF454)
EHW98_RS12070	COG1309	transcriptional regulator
EHW98_RS12075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHW98_RS12080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW98_RS12085	COG0254	rRNA binding
EHW98_RS12090	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EHW98_RS12115	COG3695	enzyme binding
EHW98_RS12120	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EHW98_RS12125	COG1946	Acyl-CoA thioesterase
EHW98_RS12130	COG0004	ammonium transporteR
EHW98_RS12135	COG0347	Belongs to the P(II) protein family
EHW98_RS12140	COG1132	(ABC) transporter
EHW98_RS12145	COG1132	(ABC) transporter
EHW98_RS12150	COG1522	sequence-specific DNA binding
EHW98_RS12160	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EHW98_RS12165	COG0824	Thioesterase
EHW98_RS12170	COG1555	photosystem II stabilization
EHW98_RS12175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHW98_RS12180	COG0776	regulation of translation
EHW98_RS12195	COG0740	serine-type endopeptidase activity
EHW98_RS12210	COG0544	peptidyl-prolyl cis-trans isomerase activity
EHW98_RS12215	COG0271	Belongs to the BolA IbaG family
EHW98_RS12220	COG3056	Lipoprotein
EHW98_RS12225	COG2223	nitrite transmembrane transporter activity
EHW98_RS12230	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHW98_RS12235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHW98_RS12240	COG1845	cytochrome c oxidase, subunit III
EHW98_RS12245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EHW98_RS12250	COG0109	protoheme IX farnesyltransferase activity
EHW98_RS12255	COG2814	Major facilitator Superfamily
EHW98_RS12260	COG1666	GTP binding
EHW98_RS12265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EHW98_RS12275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHW98_RS12275	COG0301	tRNA thio-modification
EHW98_RS12280	COG1722	exodeoxyribonuclease VII activity
EHW98_RS12285	COG0142	geranyltranstransferase activity
EHW98_RS12290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EHW98_RS12295	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EHW98_RS12300	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EHW98_RS12305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHW98_RS12310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EHW98_RS12315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHW98_RS12315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHW98_RS12320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EHW98_RS12325	COG1652	LysM domain
EHW98_RS12335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHW98_RS12340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHW98_RS12345	COG1862	Preprotein translocase
EHW98_RS12350	COG0343	queuine tRNA-ribosyltransferase activity
EHW98_RS12355	COG2246	polysaccharide biosynthetic process
EHW98_RS12370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EHW98_RS12375	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EHW98_RS12380	COG0450	alkyl hydroperoxide reductase
EHW98_RS12395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHW98_RS12405	COG5002	protein histidine kinase activity
EHW98_RS12415	COG0420	3'-5' exonuclease activity
EHW98_RS12420	COG0419	ATPase involved in DNA repair
EHW98_RS12460	COG2974	May be involved in recombination
EHW98_RS12465	COG3123	guanosine phosphorylase activity
EHW98_RS12470	COG4126	flavin adenine dinucleotide binding
EHW98_RS12495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHW98_RS12500	COG3416	Protein conserved in bacteria
EHW98_RS12505	COG1671	Belongs to the UPF0178 family
EHW98_RS12510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EHW98_RS12525	COG3250	beta-galactosidase activity
EHW98_RS12530	COG1278	Cold shock
EHW98_RS12550	COG0747	negative chemotaxis
EHW98_RS12555	COG0601	transmembrane transport
EHW98_RS12565	COG0444	Belongs to the ABC transporter superfamily
EHW98_RS12570	COG4608	Belongs to the ABC transporter superfamily
EHW98_RS12625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EHW98_RS12630	COG2832	Protein of unknown function (DUF454)
EHW98_RS12635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EHW98_RS12640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EHW98_RS12660	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EHW98_RS12665	COG2195	Cleaves the N-terminal amino acid of tripeptides
EHW98_RS12675	COG3034	peptidoglycan biosynthetic process
EHW98_RS12680	COG0121	glutamine amidotransferase
EHW98_RS12685	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EHW98_RS12690	COG1960	acyl-CoA dehydrogenase activity
EHW98_RS12695	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EHW98_RS12705	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EHW98_RS12710	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
EHW98_RS12730	COG0436	Aminotransferase
EHW98_RS12735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHW98_RS12740	COG2233	PERMEase
EHW98_RS12745	COG2351	hydroxyisourate hydrolase activity
EHW98_RS12760	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EHW98_RS12775	COG0765	amino acid transport
EHW98_RS12815	COG1715	Restriction endonuclease
EHW98_RS12820	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EHW98_RS12845	COG1953	Uracil, thiamine, allantoin
EHW98_RS12855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHW98_RS12860	COG0328	RNA-DNA hybrid ribonuclease activity
EHW98_RS12865	COG2226	methyltransferase
EHW98_RS12870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHW98_RS12875	COG0741	lytic transglycosylase activity
EHW98_RS12875	COG1388	LysM domain
EHW98_RS12885	COG3021	interspecies interaction between organisms
EHW98_RS12920	COG0542	response to heat
EHW98_RS12930	COG0564	pseudouridine synthase activity
EHW98_RS12935	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW98_RS12940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EHW98_RS12945	COG1605	Chorismate mutase
EHW98_RS12945	COG0077	Prephenate dehydratase
EHW98_RS12950	COG1605	Chorismate mutase
EHW98_RS12950	COG0287	Prephenate dehydrogenase
EHW98_RS12955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHW98_RS12975	COG0335	large ribosomal subunit rRNA binding
EHW98_RS12990	COG0228	four-way junction DNA binding
EHW98_RS12995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EHW98_RS13000	COG4137	Cytochrome C assembly protein
EHW98_RS13005	COG4536	flavin adenine dinucleotide binding
EHW98_RS13015	COG2918	glutathione biosynthetic process
EHW98_RS13020	COG1238	metal cluster binding
EHW98_RS13025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHW98_RS13050	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EHW98_RS13065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EHW98_RS13070	COG1546	Belongs to the CinA family
EHW98_RS13075	COG2951	lytic endotransglycosylase activity
EHW98_RS13080	COG5455	response to cobalt ion
EHW98_RS13100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHW98_RS13240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EHW98_RS13245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EHW98_RS13250	COG1388	LysM domain
EHW98_RS13250	COG4942	peptidase
EHW98_RS13255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EHW98_RS13260	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EHW98_RS13265	COG0585	pseudouridine synthase activity
EHW98_RS13270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EHW98_RS13275	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EHW98_RS13280	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EHW98_RS13290	COG0529	Catalyzes the synthesis of activated sulfate
EHW98_RS13295	COG2895	sulfate adenylyltransferase (ATP) activity
EHW98_RS13300	COG0175	sulfate reduction
EHW98_RS13305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EHW98_RS13305	COG1648	precorrin-2 dehydrogenase activity
EHW98_RS13315	COG0175	sulfate reduction
EHW98_RS13320	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHW98_RS13330	COG0720	synthase
EHW98_RS13340	COG0765	amino acid transport
EHW98_RS13345	COG1126	abc transporter atp-binding protein
EHW98_RS13350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW98_RS13355	COG0602	queuosine metabolic process
EHW98_RS13360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EHW98_RS13360	COG2755	lipolytic protein G-D-S-L family
EHW98_RS13365	COG0148	phosphopyruvate hydratase activity
EHW98_RS13370	COG0504	CTP synthase activity
EHW98_RS13375	COG3956	TIGRFAM MazG family protein
EHW98_RS13380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHW98_RS13385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHW98_RS13395	COG1929	Belongs to the glycerate kinase type-1 family
EHW98_RS13400	COG0716	FMN binding
EHW98_RS13405	COG0564	pseudouridine synthase activity
EHW98_RS13410	COG3098	single-species biofilm formation
EHW98_RS13420	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EHW98_RS13420	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EHW98_RS13425	COG1611	Belongs to the LOG family
EHW98_RS13430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHW98_RS13435	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EHW98_RS13440	COG2363	Small membrane protein
EHW98_RS13445	COG0583	DNA-binding transcription factor activity
EHW98_RS13455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EHW98_RS13460	COG2166	iron-sulfur cluster assembly
EHW98_RS13465	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EHW98_RS13470	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EHW98_RS13490	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHW98_RS13495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHW98_RS13495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EHW98_RS13505	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EHW98_RS13510	COG1074	ATP-dependent DNA helicase activity
EHW98_RS13520	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EHW98_RS13535	COG4795	General secretion pathway protein
EHW98_RS13545	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EHW98_RS13550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EHW98_RS13555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EHW98_RS13565	COG1051	belongs to the nudix hydrolase family
EHW98_RS13570	COG3066	DNA modification
EHW98_RS13575	COG0861	Integral membrane protein TerC family
EHW98_RS13585	COG0667	Aldo Keto reductase
EHW98_RS13595	COG0318	PFAM AMP-dependent synthetase and ligase
EHW98_RS13595	COG0204	Acyl-transferase
EHW98_RS13620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW98_RS13630	COG0768	penicillin binding
EHW98_RS13635	COG2831	hemolysin activation secretion protein
EHW98_RS13640	COG3210	domain, Protein
EHW98_RS13655	COG3210	domain, Protein
EHW98_RS13670	COG3210	domain, Protein
EHW98_RS13685	COG3210	domain, Protein
EHW98_RS13700	COG3210	domain, Protein
EHW98_RS13715	COG1609	Transcriptional regulator
EHW98_RS13725	COG0583	DNA-binding transcription factor activity
EHW98_RS13730	COG2814	Major facilitator Superfamily
EHW98_RS13740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EHW98_RS13750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EHW98_RS13760	COG4974	Belongs to the 'phage' integrase family
EHW98_RS13770	COG0697	spore germination
EHW98_RS13775	COG0716	FMN binding
EHW98_RS13785	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EHW98_RS13790	COG0354	folic acid binding
EHW98_RS13795	COG1272	protein, Hemolysin III
EHW98_RS13805	COG1028	Short-chain dehydrogenase reductase Sdr
EHW98_RS13810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHW98_RS13810	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHW98_RS13815	COG0509	glycine decarboxylation via glycine cleavage system
EHW98_RS13820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EHW98_RS13825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW98_RS13830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW98_RS13835	COG0006	proline dipeptidase activity
EHW98_RS13840	COG3079	Belongs to the UPF0149 family
EHW98_RS13845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EHW98_RS13855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EHW98_RS13860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHW98_RS13870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EHW98_RS13875	COG0583	DNA-binding transcription factor activity
EHW98_RS13885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHW98_RS13895	COG0673	inositol 2-dehydrogenase activity
EHW98_RS13910	COG2072	flavoprotein involved in K transport
EHW98_RS13925	COG0668	transmembrane transport
EHW98_RS13930	COG0191	fructose-bisphosphate aldolase activity
EHW98_RS13935	COG0126	phosphoglycerate kinase activity
EHW98_RS13940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EHW98_RS13945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EHW98_RS13950	COG0501	Belongs to the peptidase M48B family
EHW98_RS13990	COG1166	arginine decarboxylase activity
EHW98_RS13995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EHW98_RS14000	COG2814	Major facilitator Superfamily
EHW98_RS14005	COG3091	SprT-like family
EHW98_RS14010	COG2356	endonuclease I
EHW98_RS14015	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EHW98_RS14025	COG1678	Uncharacterized ACR, COG1678
EHW98_RS14030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EHW98_RS14040	COG4232	protein-disulfide reductase activity
EHW98_RS14055	COG2805	Type II/IV secretion system protein
EHW98_RS14060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EHW98_RS14065	COG0762	integral membrane protein
EHW98_RS14070	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EHW98_RS14075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EHW98_RS14085	COG3171	Protein conserved in bacteria
EHW98_RS14100	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EHW98_RS14105	COG0741	lytic transglycosylase activity
EHW98_RS14115	COG1982	Orn Lys Arg decarboxylase major
EHW98_RS14180	COG3179	chitinase
EHW98_RS14200	COG0583	DNA-binding transcription factor activity
EHW98_RS14215	COG5297	Belongs to the glycosyl hydrolase family 6
EHW98_RS14305	COG2197	response regulator
EHW98_RS14335	COG1157	protein secretion by the type III secretion system
EHW98_RS14360	COG4794	Type iii secretion
EHW98_RS14370	COG4792	protein secretion
EHW98_RS14385	COG0151	Belongs to the GarS family
EHW98_RS14390	COG0151	Belongs to the GarS family
EHW98_RS14395	COG1834	amidinotransferase
EHW98_RS14425	COG1966	Carbon starvation protein
EHW98_RS14430	COG2879	small protein
EHW98_RS14440	COG3275	phosphorelay sensor kinase activity
EHW98_RS14460	COG1522	sequence-specific DNA binding
EHW98_RS14485	COG1609	Transcriptional regulator
EHW98_RS14495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EHW98_RS14500	COG1447	Phosphotransferase system cellobiose-specific component IIA
EHW98_RS14505	COG2723	6-phospho-beta-galactosidase activity
EHW98_RS14510	COG2723	6-phospho-beta-galactosidase activity
EHW98_RS14525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EHW98_RS14535	COG1528	Iron-storage protein
EHW98_RS14545	COG0671	phosphoesterase, PA-phosphatase related
EHW98_RS14570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHW98_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
EHW98_RS14610	COG0848	biopolymer transport protein
EHW98_RS14620	COG0626	cystathionine gamma-synthase activity
EHW98_RS14625	COG0586	Pfam SNARE associated Golgi protein
EHW98_RS14630	COG0076	glutamate decarboxylase activity
EHW98_RS14635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHW98_RS14640	COG2207	Transcriptional regulator
EHW98_RS14645	COG0656	L-ascorbic acid biosynthetic process
EHW98_RS14650	COG2132	Multicopper oxidase
EHW98_RS14710	COG0318	PFAM AMP-dependent synthetase and ligase
EHW98_RS14710	COG0300	oxidoreductase activity
EHW98_RS14710	COG3321	synthase
EHW98_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
EHW98_RS14710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EHW98_RS14725	COG0167	dihydroorotate dehydrogenase activity
EHW98_RS14750	COG3150	esterase
EHW98_RS14755	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EHW98_RS14760	COG3151	Protein conserved in bacteria
EHW98_RS14765	COG0494	nUDIX hydrolase
EHW98_RS14770	COG1538	Outer membrane efflux protein
EHW98_RS14775	COG5463	Belongs to the UPF0441 family
EHW98_RS14780	COG0754	glutathionylspermidine amidase activity
EHW98_RS14785	COG3384	dioxygenase
EHW98_RS14790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHW98_RS14800	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EHW98_RS14800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EHW98_RS14810	COG3025	triphosphatase activity
EHW98_RS14815	COG4991	sh3 domain protein
EHW98_RS14820	COG0617	tRNA 3'-terminal CCA addition
EHW98_RS14825	COG1968	undecaprenyl-diphosphatase activity
EHW98_RS14830	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EHW98_RS14835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EHW98_RS14840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EHW98_RS14845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EHW98_RS14850	COG0358	DNA primase activity
EHW98_RS14860	COG3663	DNA glycosylase
EHW98_RS14875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EHW98_RS14880	COG3423	Transcriptional regulator
EHW98_RS14890	COG1464	Belongs to the NlpA lipoprotein family
EHW98_RS14895	COG3012	SEC-C Motif Domain Protein
EHW98_RS14895	COG3318	Belongs to the UPF0149 family
EHW98_RS14900	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EHW98_RS14940	COG2003	Belongs to the UPF0758 family
EHW98_RS14990	COG1715	Restriction endonuclease
EHW98_RS15010	COG0582	viral genome integration into host DNA
EHW98_RS15025	COG0433	COG0433 Predicted ATPase
EHW98_RS15030	COG2733	membrane
EHW98_RS15035	COG0795	lipopolysaccharide-transporting ATPase activity
EHW98_RS15040	COG0795	lipopolysaccharide-transporting ATPase activity
EHW98_RS15045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHW98_RS15050	COG2927	DNA polymerase III (CHI subunit)
EHW98_RS15055	COG0525	valine-tRNA ligase activity
EHW98_RS15065	COG2271	Major facilitator Superfamily
EHW98_RS15080	COG0456	acetyltransferase
EHW98_RS15085	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
EHW98_RS15090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EHW98_RS15100	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EHW98_RS15110	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EHW98_RS15115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHW98_RS15125	COG0602	queuosine metabolic process
EHW98_RS15130	COG3766	membrane
EHW98_RS15135	COG2827	Endonuclease containing a URI domain
EHW98_RS15140	COG3153	acetyltransferase
EHW98_RS15145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW98_RS15150	COG0513	Belongs to the DEAD box helicase family
EHW98_RS15165	COG1185	polyribonucleotide nucleotidyltransferase activity
EHW98_RS15170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EHW98_RS15175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EHW98_RS15180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EHW98_RS15190	COG0195	Participates in both transcription termination and antitermination
EHW98_RS15195	COG0779	Required for maturation of 30S ribosomal subunits
EHW98_RS15210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EHW98_RS15215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHW98_RS15220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EHW98_RS15230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EHW98_RS15235	COG1534	Rna-binding protein
EHW98_RS15245	COG2027	D-alanyl-D-alanine carboxypeptidase
EHW98_RS15250	COG0745	RESPONSE REGULATOR receiver
EHW98_RS15255	COG0642	Histidine kinase
EHW98_RS15260	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EHW98_RS15270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EHW98_RS15275	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EHW98_RS15280	COG0142	geranyltranstransferase activity
EHW98_RS15285	COG3423	Transcriptional regulator
EHW98_RS15290	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EHW98_RS15295	COG5007	Belongs to the BolA IbaG family
EHW98_RS15300	COG3113	response to antibiotic
EHW98_RS15305	COG2854	intermembrane phospholipid transfer
EHW98_RS15310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHW98_RS15315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHW98_RS15320	COG1127	ABC transporter
EHW98_RS15325	COG0530	calcium, potassium:sodium antiporter activity
EHW98_RS15335	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EHW98_RS15340	COG3117	lipopolysaccharide transmembrane transporter activity
EHW98_RS15345	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EHW98_RS15350	COG1137	ATPase activity
EHW98_RS15355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EHW98_RS15370	COG1660	Displays ATPase and GTPase activities
EHW98_RS15375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW98_RS15385	COG5002	protein histidine kinase activity
EHW98_RS15385	COG2198	Histidine kinase
EHW98_RS15385	COG0784	Response regulator, receiver
EHW98_RS15390	COG0067	glutamate synthase
EHW98_RS15390	COG0070	glutamate synthase
EHW98_RS15390	COG0069	glutamate synthase activity
EHW98_RS15395	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EHW98_RS15400	COG2969	positive regulation of protein catabolic process
EHW98_RS15405	COG0625	glutathione transferase activity
EHW98_RS15410	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EHW98_RS15415	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EHW98_RS15420	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EHW98_RS15425	COG3105	Protein conserved in bacteria
EHW98_RS15430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHW98_RS15435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHW98_RS15440	COG0039	L-malate dehydrogenase activity
EHW98_RS15445	COG1438	arginine binding
EHW98_RS15460	COG1289	transmembrane transporter activity
EHW98_RS15465	COG1566	PFAM secretion protein HlyD family protein
EHW98_RS15475	COG0583	DNA-binding transcription factor activity
EHW98_RS15480	COG0312	modulator of DNA gyrase
EHW98_RS15485	COG3164	Protein of unknown function
EHW98_RS15490	COG1530	ribonuclease E activity
EHW98_RS15500	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EHW98_RS15505	COG1792	Involved in formation and maintenance of cell shape
EHW98_RS15510	COG1077	Cell shape determining protein MreB Mrl
EHW98_RS15515	COG2199	diguanylate cyclase activity
EHW98_RS15515	COG2200	EAL domain
EHW98_RS15520	COG0604	alcohol dehydrogenase
EHW98_RS15525	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EHW98_RS15535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EHW98_RS15540	COG0511	ligase activity, forming carbon-carbon bonds
EHW98_RS15545	COG0439	Biotin carboxylase
EHW98_RS15550	COG3924	membrane
EHW98_RS15555	COG4145	pantothenate transmembrane transporter activity
EHW98_RS15560	COG2264	protein methyltransferase activity
EHW98_RS15580	COG1560	Kdo2-lipid A biosynthetic process
EHW98_RS15585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW98_RS15590	COG4597	amino acid ABC transporter
EHW98_RS15595	COG0765	amino acid transport
EHW98_RS15600	COG1126	abc transporter atp-binding protein
EHW98_RS15635	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EHW98_RS15645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHW98_RS15655	COG0551	DNA topoisomerase type I activity
EHW98_RS15660	COG2922	Belongs to the Smg family
EHW98_RS15665	COG0758	DNA mediated transformation
EHW98_RS15670	COG0242	peptide deformylase activity
EHW98_RS15675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHW98_RS15680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EHW98_RS15680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHW98_RS15690	COG1970	mechanosensitive ion channel activity
EHW98_RS15700	COG3036	rescue of stalled ribosome
EHW98_RS15705	COG0789	Transcriptional regulator
EHW98_RS15715	COG0203	ribosomal protein L17
EHW98_RS15720	COG0202	RNA polymerase activity
EHW98_RS15725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EHW98_RS15730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EHW98_RS15735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EHW98_RS15740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EHW98_RS15745	COG0201	protein transport
EHW98_RS15750	COG0200	Binds to the 23S rRNA
EHW98_RS15755	COG1841	ribosomal large subunit assembly
EHW98_RS15765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EHW98_RS15770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EHW98_RS15775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EHW98_RS15780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EHW98_RS15785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EHW98_RS15790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EHW98_RS15795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EHW98_RS15800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EHW98_RS15805	COG0255	Belongs to the universal ribosomal protein uL29 family
EHW98_RS15810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EHW98_RS15820	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EHW98_RS15825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EHW98_RS15830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EHW98_RS15835	COG0089	rRNA binding
EHW98_RS15840	COG0088	Forms part of the polypeptide exit tunnel
EHW98_RS15845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EHW98_RS15850	COG0051	transcription antitermination factor activity, RNA binding
EHW98_RS15860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHW98_RS15865	COG0049	tRNA binding
EHW98_RS15870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EHW98_RS15875	COG2168	tRNA wobble position uridine thiolation
EHW98_RS15880	COG2923	Belongs to the DsrF TusC family
EHW98_RS15885	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EHW98_RS15890	COG2964	Protein conserved in bacteria
EHW98_RS15895	COG0545	Peptidyl-prolyl cis-trans isomerase
EHW98_RS15900	COG2900	Belongs to the SlyX family
EHW98_RS15905	COG1047	Peptidyl-prolyl cis-trans
EHW98_RS15910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EHW98_RS15915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EHW98_RS15915	COG0475	glutathione-regulated potassium exporter activity
EHW98_RS15920	COG2249	NAD(P)H dehydrogenase (quinone) activity
EHW98_RS15925	COG0488	(ABC) transporter
EHW98_RS15935	COG2175	clavaminate synthase activity
EHW98_RS15940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW98_RS15950	COG4521	taurine ABC transporter
EHW98_RS15960	COG0429	hydrolase of the alpha beta-hydrolase fold
EHW98_RS15965	COG3089	Belongs to the UPF0270 family
EHW98_RS15970	COG3954	Phosphoribulokinase
EHW98_RS15975	COG1765	OsmC-like protein
EHW98_RS15985	COG1289	transmembrane transporter activity
EHW98_RS15990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EHW98_RS16005	COG0738	Major facilitator superfamily
EHW98_RS16010	COG0402	S-adenosylhomocysteine deaminase activity
EHW98_RS16015	COG0402	S-adenosylhomocysteine deaminase activity
EHW98_RS16040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EHW98_RS16050	COG3266	domain, Protein
EHW98_RS16055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EHW98_RS16060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHW98_RS16065	COG4796	Type ii and iii secretion system protein
EHW98_RS16090	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EHW98_RS16095	COG0494	nUDIX hydrolase
EHW98_RS16105	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EHW98_RS16110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EHW98_RS16115	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EHW98_RS16125	COG0745	RESPONSE REGULATOR receiver
EHW98_RS16130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHW98_RS16135	COG2183	response to ionizing radiation
EHW98_RS16140	COG0366	Alpha amylase catalytic
EHW98_RS16150	COG1040	competence protein
EHW98_RS16155	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EHW98_RS16155	COG0316	Belongs to the HesB IscA family
EHW98_RS16160	COG1640	4-alpha-glucanotransferase
EHW98_RS16165	COG0058	SHG alpha-glucan phosphorylase activity
EHW98_RS16170	COG1349	DNA-binding transcription factor activity
EHW98_RS16175	COG0705	Rhomboid family
EHW98_RS16180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHW98_RS16185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EHW98_RS16200	COG0058	SHG alpha-glucan phosphorylase activity
EHW98_RS16205	COG0297	glycogen (starch) synthase activity
EHW98_RS16215	COG1523	belongs to the glycosyl hydrolase 13 family
EHW98_RS16230	COG2610	gluconate transmembrane transporter activity
EHW98_RS16235	COG3265	gluconokinase activity
EHW98_RS16240	COG1609	Transcriptional regulator
EHW98_RS16245	COG1741	Belongs to the pirin family
EHW98_RS16250	COG1247	-acetyltransferase
EHW98_RS16255	COG0405	Gamma-glutamyltransferase
EHW98_RS16265	COG0584	glycerophosphoryl diester phosphodiesterase
EHW98_RS16275	COG0395	ABC-type sugar transport system, permease component
EHW98_RS16285	COG1653	transport
EHW98_RS16295	COG0411	ABC transporter
EHW98_RS16300	COG4177	L-phenylalanine transmembrane transporter activity
EHW98_RS16315	COG0456	acetyltransferase
EHW98_RS16325	COG2177	Part of the ABC transporter FtsEX involved in
EHW98_RS16330	COG2884	Cell division ATP-binding protein ftsE
EHW98_RS16335	COG0552	protein localization to endoplasmic reticulum
EHW98_RS16340	COG0742	ribosomal rna small subunit methyltransferase
EHW98_RS16345	COG3776	membrane
EHW98_RS16350	COG3714	YhhN family
EHW98_RS16360	COG0425	Belongs to the sulfur carrier protein TusA family
EHW98_RS16365	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EHW98_RS16375	COG1082	Xylose isomerase domain protein TIM barrel
EHW98_RS16380	COG0673	inositol 2-dehydrogenase activity
EHW98_RS16385	COG3962	Belongs to the TPP enzyme family
EHW98_RS16390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW98_RS16400	COG3718	enzyme involved in inositol metabolism
EHW98_RS16410	COG0628	permease
EHW98_RS16415	COG2200	EAL domain
EHW98_RS16425	COG1064	alcohol dehydrogenase
EHW98_RS16460	COG2081	HI0933 family
EHW98_RS16465	COG0306	phosphate transporter
EHW98_RS16475	COG0589	response to stress
EHW98_RS16480	COG0742	ribosomal rna small subunit methyltransferase
EHW98_RS16505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EHW98_RS16510	COG1234	tRNA 3'-trailer cleavage
EHW98_RS16515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHW98_RS16525	COG3038	cytochrome b561
EHW98_RS16550	COG2862	Uncharacterized protein family, UPF0114
EHW98_RS16575	COG2207	Transcriptional regulator
EHW98_RS16575	COG3708	Transcriptional regulator
EHW98_RS16595	COG1132	(ABC) transporter
EHW98_RS16600	COG0840	transmembrane signaling receptor activity
EHW98_RS16605	COG3386	PFAM SMP-30 Gluconolaconase
EHW98_RS16615	COG2205	protein histidine kinase activity
EHW98_RS16620	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EHW98_RS16625	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EHW98_RS16630	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EHW98_RS16680	COG0673	inositol 2-dehydrogenase activity
EHW98_RS16695	COG0673	inositol 2-dehydrogenase activity
EHW98_RS16700	COG1971	Probably functions as a manganese efflux pump
EHW98_RS16725	COG0477	Major facilitator Superfamily
EHW98_RS16730	COG2982	Protein involved in outer membrane biogenesis
EHW98_RS16735	COG2200	EAL domain
EHW98_RS16750	COG1301	dicarboxylic acid transport
EHW98_RS16755	COG2200	EAL domain
EHW98_RS16755	COG2199	diguanylate cyclase activity
EHW98_RS16765	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EHW98_RS16775	COG0457	Tetratricopeptide repeat
EHW98_RS16780	COG1215	transferase activity, transferring glycosyl groups
EHW98_RS16785	COG1215	transferase activity, transferring glycosyl groups
EHW98_RS16790	COG2894	cell division
EHW98_RS16800	COG4608	Belongs to the ABC transporter superfamily
EHW98_RS16805	COG0444	Belongs to the ABC transporter superfamily
EHW98_RS16810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW98_RS16815	COG0601	transmembrane transport
EHW98_RS16820	COG0747	negative chemotaxis
EHW98_RS16835	COG1764	response to oxidative stress
EHW98_RS16840	COG1846	Transcriptional regulator
EHW98_RS16880	COG0246	Mannitol dehydrogenase
EHW98_RS16890	COG3274	enterobacterial common antigen metabolic process
EHW98_RS16895	COG0752	glycyl-tRNA synthetase alpha subunit
EHW98_RS16900	COG0751	glycine-tRNA ligase activity
EHW98_RS16905	COG1064	alcohol dehydrogenase
EHW98_RS16910	COG2944	sequence-specific DNA binding
EHW98_RS16920	COG2213	PTS system mannitol-specific
EHW98_RS16920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW98_RS16925	COG0246	Mannitol dehydrogenase
EHW98_RS16930	COG3722	fumarate hydratase activity
EHW98_RS16950	COG0745	RESPONSE REGULATOR receiver
EHW98_RS16960	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW98_RS16965	COG1129	ABC transporter
EHW98_RS16970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EHW98_RS16975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHW98_RS16980	COG1349	DNA-binding transcription factor activity
EHW98_RS16990	COG3058	Necessary for formate dehydrogenase activity
EHW98_RS16995	COG0625	glutathione transferase activity
EHW98_RS17000	COG2818	Glycosylase
EHW98_RS17005	COG2885	chlorophyll binding
EHW98_RS17010	COG1609	Transcriptional regulator
EHW98_RS17030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW98_RS17035	COG2271	Major facilitator Superfamily
EHW98_RS17040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHW98_RS17055	COG3977	Valine--pyruvate aminotransferase
EHW98_RS17065	COG5645	(Lipo)protein
EHW98_RS17070	COG0823	Involved in the tonB-independent uptake of proteins
EHW98_RS17075	COG0561	phosphatase activity
EHW98_RS17080	COG0187	DNA topoisomerase II activity
EHW98_RS17085	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EHW98_RS17090	COG0592	DNA-directed DNA polymerase activity
EHW98_RS17095	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EHW98_RS17100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EHW98_RS17105	COG0594	ribonuclease P activity
EHW98_RS17115	COG0706	membrane insertase activity
EHW98_RS17120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EHW98_RS17125	COG2091	lysine biosynthetic process via aminoadipic acid
EHW98_RS17130	COG2252	PERMEase
EHW98_RS17140	COG2814	Major facilitator Superfamily
EHW98_RS17145	COG0704	Plays a role in the regulation of phosphate uptake
EHW98_RS17150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHW98_RS17155	COG0581	inorganic phosphate transmembrane transporter activity
EHW98_RS17160	COG0573	inorganic phosphate transmembrane transporter activity
EHW98_RS17165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EHW98_RS17185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EHW98_RS17190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EHW98_RS17195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EHW98_RS17200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EHW98_RS17205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EHW98_RS17210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EHW98_RS17215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EHW98_RS17220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EHW98_RS17230	COG0356	it plays a direct role in the translocation of protons across the membrane
EHW98_RS17235	COG3312	ion transport
EHW98_RS17240	COG0357	Ribosomal RNA small subunit methyltransferase G
EHW98_RS17265	COG0583	DNA-binding transcription factor activity
EHW98_RS17270	COG1012	belongs to the aldehyde dehydrogenase family
EHW98_RS17280	COG4628	conserved protein (DUF2132)
EHW98_RS17345	COG1192	Involved in chromosome partitioning
EHW98_RS17355	COG0500	methyltransferase
EHW98_RS17360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHW98_RS17380	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine