locus-tag class description EHW99_RS00005 ENOG4105QTB Flavodoxin EHW99_RS00010 ENOG4108VVK transcriptional Regulator, AsnC EHW99_RS00020 ENOG4105EV2 VWA domain protein interacting with AAA ATPase EHW99_RS00030 ENOG4105DFH Transport of potassium into the cell (By similarity) EHW99_RS00050 ENOG4105H4F exported protein EHW99_RS00065 ENOG4105C7K acetolactate synthase EHW99_RS00070 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EHW99_RS00075 ENOG4105C2J ABC transporter EHW99_RS00080 ENOG4105CNN ABC, transporter EHW99_RS00085 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EHW99_RS00090 ENOG4108RVA ribokinase EHW99_RS00095 ENOG4105ETE Transcriptional regulator (LacI family EHW99_RS00100 ENOG4105C0R drug resistance transporter emrb qaca subfamily EHW99_RS00130 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EHW99_RS00135 ENOG4105PC1 Conserved Protein EHW99_RS00145 ENOG4108Z33 Thiol disulfide Interchange Protein EHW99_RS00150 ENOG4105C2M dna polymerase I EHW99_RS00160 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) EHW99_RS00165 ENOG4105D4P Coproporphyrinogen iii oxidase EHW99_RS00170 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EHW99_RS00175 ENOG4105CUX Signal transduction histidine kinase EHW99_RS00180 ENOG4105C5F glutamine synthetase EHW99_RS00185 ENOG4105CI3 gtp-binding protein typa EHW99_RS00190 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 EHW99_RS00200 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EHW99_RS00205 ENOG4105SUU thioesterase domain EHW99_RS00210 ENOG4105FE9 pseudouridine synthase EHW99_RS00215 ENOG4105JV1 AsmA family EHW99_RS00220 ENOG4105C2W permease EHW99_RS00225 ENOG4105CB5 ATP-dependent DNA helicase recG EHW99_RS00230 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase EHW99_RS00235 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EHW99_RS00240 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) EHW99_RS00245 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EHW99_RS00250 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) EHW99_RS00255 ENOG4105EN6 Membrane EHW99_RS00260 ENOG41068CG regulatoR EHW99_RS00270 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EHW99_RS00325 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 EHW99_RS00340 ENOG4105DSJ YicC domain protein EHW99_RS00350 ENOG4105D9N nucleoside EHW99_RS00355 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EHW99_RS00360 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EHW99_RS00365 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) EHW99_RS00370 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) EHW99_RS00375 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EHW99_RS00380 ENOG4105W5Q DNA repair protein (RadC EHW99_RS00385 ENOG4105KDC 50s ribosomal protein l28 EHW99_RS00395 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EHW99_RS00400 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EHW99_RS00405 ENOG4106WTF Glycosyl transferase, family 2 EHW99_RS00410 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase EHW99_RS00415 ENOG4105XA0 heptosyltransferase ii EHW99_RS00420 ENOG4105CPK Glycosyl transferase (Group 1 EHW99_RS00430 ENOG4105DKP glycosyl transferase, family 9 EHW99_RS00450 ENOG41068PG O-Antigen polymerase EHW99_RS00455 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) EHW99_RS00460 ENOG4105D16 lipopolysaccharide heptosyltransferase i EHW99_RS00465 ENOG4105XA0 heptosyltransferase ii EHW99_RS00470 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) EHW99_RS00475 ENOG4105PXI polysaccharide deacetylase EHW99_RS00480 ENOG41063SB peptidase EHW99_RS00485 ENOG4107YZP Rhodanese domain protein EHW99_RS00490 ENOG4105VW4 glutaredoxin 3 EHW99_RS00495 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) EHW99_RS00500 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EHW99_RS00505 ENOG4105D7W serine acetyltransferase EHW99_RS00510 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EHW99_RS00515 ENOG4105E0F Histidine kinase EHW99_RS00520 ENOG4105E3W Two component transcriptional regulator (Winged helix family EHW99_RS00525 ENOG4105FMW periplasmic EHW99_RS00530 ENOG41076HS cation diffusion facilitator family transporter EHW99_RS00535 ENOG4105CTQ phosphohexokinase EHW99_RS00540 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EHW99_RS00545 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) EHW99_RS00550 ENOG4107H3J ribonuclease EHW99_RS00555 ENOG4105JAB phenazine biosynthesis protein, phzf family EHW99_RS00565 ENOG4105DWT malate dehydrogenase (quinone) EHW99_RS00575 ENOG4105CP7 Triose-phosphate isomerase EHW99_RS00580 ENOG4105EBK exported protein EHW99_RS00585 ENOG4108VTS Membrane EHW99_RS00590 ENOG4105DP0 ferredoxin-NADP reductase EHW99_RS00600 ENOG4105E5M Multidrug resistance protein D EHW99_RS00605 ENOG4105CBT Fructose-1,6-bisphosphatase EHW99_RS00620 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EHW99_RS00625 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) EHW99_RS00630 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) EHW99_RS00635 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) EHW99_RS00640 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EHW99_RS00645 ENOG41063M6 Cell Division Protein EHW99_RS00650 ENOG4105ETE Transcriptional regulator (LacI family EHW99_RS00655 ENOG4105C25 Primosomal protein n' EHW99_RS00660 ENOG4105VFB Binds the 23S rRNA (By similarity) EHW99_RS00665 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) EHW99_RS00670 ENOG4105C28 cystathionine EHW99_RS00675 ENOG4105CFH Aspartokinase EHW99_RS00680 ENOG4105SYT Methylenetetrahydrofolate reductase EHW99_RS00685 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) EHW99_RS00690 ENOG4105CWC Acetylornithine deacetylase EHW99_RS00695 ENOG4105CAS nag kinase EHW99_RS00700 ENOG4105CDH Citrulline--aspartate ligase EHW99_RS00705 ENOG4105CH7 arginosuccinase EHW99_RS00710 ENOG4105EHV domain protein EHW99_RS00715 ENOG4105C5Q Transcriptional regulator EHW99_RS00720 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) EHW99_RS00725 ENOG4105EJ2 Transcriptional regulator EHW99_RS00730 ENOG4108Y73 Membrane EHW99_RS00735 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) EHW99_RS00740 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EHW99_RS00775 ENOG4105CVI Transcriptional regulator EHW99_RS00780 ENOG4108WFC UPF0438 protein yifE EHW99_RS00785 ENOG4105C0P Mg chelatase subunit ChlI EHW99_RS00800 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit EHW99_RS00805 ENOG4105CM2 brancheD-chain amino acid aminotransferase EHW99_RS00810 ENOG4105C01 Dihydroxy-acid dehydratase EHW99_RS00815 ENOG4105C7B Threonine dehydratase EHW99_RS00820 ENOG4105EMY transcriptional regulator EHW99_RS00825 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EHW99_RS00830 ENOG4105KQ5 peptidylprolyl cis-trans isomerase EHW99_RS00835 ENOG4105C4R Atp-dependent dna helicase EHW99_RS00840 ENOG4105C9X ppx gppa phosphatase EHW99_RS00845 ENOG4105C1J atp-dependent rna helicase EHW99_RS00855 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EHW99_RS00860 ENOG4105ESV Glycosyl transferase, family 4 EHW99_RS00865 ENOG4105SFE lipopolysaccharide biosynthesis protein EHW99_RS00870 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EHW99_RS00875 ENOG4108IJ1 Dehydrogenase EHW99_RS00880 ENOG4105C1B dTDP-glucose 4-6-dehydratase EHW99_RS00885 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EHW99_RS00890 ENOG4108WJ1 acetyltransferase EHW99_RS00895 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EHW99_RS00900 ENOG4105EGZ biosynthesis protein EHW99_RS00905 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) EHW99_RS00910 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) EHW99_RS00915 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family EHW99_RS00955 ENOG410601J HemY protein EHW99_RS00960 ENOG4105ECF c-methyltransferase EHW99_RS00965 ENOG41076E6 Uroporphyrinogen-III Synthase EHW99_RS00970 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EHW99_RS00975 ENOG4107T0K Adenylate cyclase EHW99_RS00980 ENOG4105S7Z (LipO)protein EHW99_RS00985 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EHW99_RS00990 ENOG4105CT0 Protein of unknown function, DUF484 EHW99_RS01000 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant EHW99_RS01005 ENOG4105C4R Atp-dependent dna helicase EHW99_RS01010 ENOG4107QUT magnesium and cobalt transport protein CorA EHW99_RS01015 ENOG4108VUY thioesterase Superfamily protein EHW99_RS01020 ENOG4105HDD phospholipase EHW99_RS01025 ENOG4105C9U ATP-dependent DNA helicase RecQ EHW99_RS01030 ENOG410829K Lysine exporter protein (Lyse ygga) EHW99_RS01035 ENOG4108EUD Lysophospholipase EHW99_RS01040 ENOG4105DQF Hydrolase EHW99_RS01045 ENOG4105CXY transporter EHW99_RS01050 ENOG4108W15 Protein of unknown function (DUF1456) EHW99_RS01055 ENOG4105DZ2 Transcriptional regulator EHW99_RS01060 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EHW99_RS01065 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) EHW99_RS01070 ENOG4107SXA Phosphorylase EHW99_RS01075 ENOG4105CGY Dna recombination protein EHW99_RS01080 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EHW99_RS01085 ENOG4105JC1 sterol-binding domain protein EHW99_RS01090 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) EHW99_RS01095 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EHW99_RS01100 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) EHW99_RS01105 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EHW99_RS01115 ENOG4105MDZ Transcriptional activator rfaH EHW99_RS01120 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EHW99_RS01125 ENOG4107QK7 reductase EHW99_RS01130 ENOG4105CHU acetyl-coa acetyltransferase EHW99_RS01135 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) EHW99_RS01140 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) EHW99_RS01145 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EHW99_RS01150 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) EHW99_RS01155 ENOG4108RR8 protoporphyrinogen oxidase EHW99_RS01180 ENOG4105D4A Cell wall formation (By similarity) EHW99_RS01185 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase EHW99_RS01190 ENOG4105CS9 pantothenic acid kinase EHW99_RS01215 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EHW99_RS01220 ENOG4105PM1 preprotein translocase subunit SecE EHW99_RS01225 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EHW99_RS01230 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EHW99_RS01235 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EHW99_RS01240 ENOG4108VZM 50s ribosomal protein L10 EHW99_RS01245 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EHW99_RS01250 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EHW99_RS01255 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EHW99_RS01300 ENOG4108NC2 Outer membrane protease EHW99_RS01305 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EHW99_RS01310 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EHW99_RS01315 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) EHW99_RS01320 ENOG4105E09 nadh pyrophosphatase EHW99_RS01325 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EHW99_RS01330 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) EHW99_RS01335 ENOG4105R2J Conserved Protein EHW99_RS01340 ENOG4105K70 DNA-binding protein EHW99_RS01345 ENOG4108T8B Protein of unknown function (DUF1481) EHW99_RS01350 ENOG4105C12 Phosphoribosylglycinamide synthetase EHW99_RS01355 ENOG4105DC1 bifunctional purine biosynthesis protein purh EHW99_RS01380 ENOG4105CVG Homoserine O-transsuccinylase EHW99_RS01385 ENOG4105EAM Na Pi-cotransporter EHW99_RS01390 ENOG4105CFH Aspartokinase EHW99_RS01395 ENOG4107QP8 phosphohexose isomerase EHW99_RS01405 ENOG4108Y9B (LipO)protein EHW99_RS01410 ENOG4108W78 Pfam:DUF1017 EHW99_RS01415 ENOG4105E3R (LipO)protein EHW99_RS01420 ENOG4108VY7 phosphate-starvation-inducible protein PsiE EHW99_RS01425 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) EHW99_RS01440 ENOG41080IJ Diacylglycerol kinase EHW99_RS01445 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EHW99_RS01450 ENOG4107R73 Mate efflux family protein EHW99_RS01455 ENOG4105VDW Csbd family EHW99_RS01460 ENOG4105MYN Zinc uptake regulation protein EHW99_RS01480 ENOG4108MXB Protein of unknown function (DUF968) EHW99_RS01485 ENOG4105HRS Antitermination protein EHW99_RS01530 ENOG4105UZW Tail fiber assembly protein EHW99_RS01540 ENOG4105CKK Glycosyl transferase, family 2 EHW99_RS01545 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) EHW99_RS01560 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EHW99_RS01565 ENOG4105P4Z Phage shock protein G EHW99_RS01570 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EHW99_RS01575 ENOG4105CDU Replicative dna helicase EHW99_RS01585 ENOG4105CGF Aromatic amino acid aminotransferase EHW99_RS01590 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EHW99_RS01595 ENOG4105MSB protein, conserved in bacteria EHW99_RS01600 ENOG4105TNG K13735 adhesin invasin EHW99_RS01605 ENOG4105DQ4 alcohol dehydrogenase EHW99_RS01610 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EHW99_RS01615 ENOG4108UUM single-stranded DNA-binding protein EHW99_RS01620 ENOG4105D5K Hemolysin activator protein EHW99_RS01640 ENOG4108W3Q Transcriptional regulator EHW99_RS01645 ENOG4108Z4X TRANSCRIPTIONal EHW99_RS01655 ENOG4105C7N Xanthine uracil vitamin C permease EHW99_RS01660 ENOG4105EEQ Na H antiporter EHW99_RS01665 ENOG4105CMU LysR family (Transcriptional regulator EHW99_RS01675 ENOG41067MG lrgb family EHW99_RS01680 ENOG4108UII YfaZ family EHW99_RS01685 ENOG4107QN1 sodium solute EHW99_RS01690 ENOG41062QD Membrane EHW99_RS01695 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EHW99_RS01700 ENOG4105CK2 sodium dicarboxylate symporter EHW99_RS01705 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor EHW99_RS01725 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 EHW99_RS01730 ENOG4105BZU Histidine kinase EHW99_RS01765 ENOG410642W LysR family Transcriptional regulator EHW99_RS01780 ENOG4105CC0 LysR family Transcriptional regulator EHW99_RS01785 ENOG410829K Lysine exporter protein (Lyse ygga) EHW99_RS01795 ENOG4105DYC esterase EHW99_RS01800 ENOG4105E32 cytoplasmic protein EHW99_RS01805 ENOG4108HCJ Hydrolase EHW99_RS01815 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EHW99_RS01825 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EHW99_RS01835 ENOG4105E0K tonB-dependent siderophore receptor EHW99_RS01840 ENOG4105DUU IucA IucC family protein EHW99_RS01845 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) EHW99_RS01850 ENOG4105DY8 decarboxylase EHW99_RS01910 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EHW99_RS02035 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EHW99_RS02050 ENOG4105CUT histidyl-tRNA synthetase EHW99_RS02065 ENOG4105CAQ asparagine synthetase EHW99_RS02075 ENOG4105E5W Transporter EHW99_RS02090 ENOG4108SIC Transcriptional regulator EHW99_RS02100 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter EHW99_RS02105 ENOG4108IJ0 Aspartate ammonia-lyase EHW99_RS02110 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 EHW99_RS02115 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EHW99_RS02120 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EHW99_RS02125 ENOG4108ZVF (LipO)protein EHW99_RS02130 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EHW99_RS02135 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EHW99_RS02150 ENOG4105QNF Outer membrane lipoprotein EHW99_RS02155 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) EHW99_RS02160 ENOG4105EGS Mechanosensitive ion channel EHW99_RS02165 ENOG4105DJ4 phosphatidylserine decarboxylase EHW99_RS02170 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EHW99_RS02175 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) EHW99_RS02200 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EHW99_RS02205 ENOG4105K8N protein family UPF0079, ATPase EHW99_RS02210 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EHW99_RS02215 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EHW99_RS02220 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EHW99_RS02230 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EHW99_RS02235 ENOG4107QJR hflk protein EHW99_RS02240 ENOG4105EPW hflc protein EHW99_RS02250 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EHW99_RS02255 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EHW99_RS02260 ENOG4105C2N RNA methyltransferase TrmH family group 3 EHW99_RS02270 ENOG4105C8Q Methyl-accepting chemotaxis EHW99_RS02275 ENOG4108MXZ Esterase EHW99_RS02280 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EHW99_RS02285 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) EHW99_RS02290 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EHW99_RS02295 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EHW99_RS02300 ENOG4105FHY Opacity-associated protein A EHW99_RS02305 ENOG4108V1T peptidylprolyl cis-trans isomerase EHW99_RS02310 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic EHW99_RS02315 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EHW99_RS02320 ENOG41061GZ Protein of unknown function (DUF1107) EHW99_RS02325 ENOG4105C37 (CBS) domain EHW99_RS02330 ENOG4105CFU surface antigen EHW99_RS02340 ENOG4108ZHD aig2 family EHW99_RS02345 ENOG4105F0N pyrophosphate phospho-hydrolase EHW99_RS02350 ENOG4105C8Q Methyl-accepting chemotaxis EHW99_RS02355 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 EHW99_RS02360 ENOG4105DFU Cell wall formation (By similarity) EHW99_RS02365 ENOG4105N42 UPF0307 protein EHW99_RS02370 ENOG4105CMS peptidase U62, modulator of DNA gyrase EHW99_RS02405 ENOG41069H0 dihydroorotase EC 3.5.2.3 EHW99_RS02420 ENOG4105EMD TRANSCRIPTIONal EHW99_RS02425 ENOG4105W4M Transport-associated protein EHW99_RS02430 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) EHW99_RS02435 ENOG41082RQ UPF0102 protein EHW99_RS02440 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) EHW99_RS02445 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EHW99_RS02470 ENOG4108CNN domain protein EHW99_RS02475 ENOG4105CWB LysR family transcriptional Regulator EHW99_RS02485 ENOG4108VBZ doxx family EHW99_RS02490 ENOG4105YJD EHW99_RS02495 ENOG41090KG Inner membrane protein YqjE EHW99_RS02500 ENOG4105NE1 Conserved Protein EHW99_RS02505 ENOG4105WAY exported protein EHW99_RS02510 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) EHW99_RS02515 ENOG4106W5V Membrane EHW99_RS02525 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) EHW99_RS02530 ENOG4105DU1 integral membrane protein, terc EHW99_RS02540 ENOG4105CPQ Dehydrogenase EHW99_RS02545 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 EHW99_RS02550 ENOG4106UW1 Major Facilitator superfamily EHW99_RS02555 ENOG4108VKG metal-dependent hydrolase EHW99_RS02560 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EHW99_RS02565 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EHW99_RS02575 ENOG41077A9 carbonic anhydrase EHW99_RS02580 ENOG4105CHH sulfate transporter EHW99_RS02585 ENOG4108IGT Dipeptidase EHW99_RS02595 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) EHW99_RS02600 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) EHW99_RS02610 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E EHW99_RS02615 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF EHW99_RS02625 ENOG410787A Pts system, glucitol sorbitol-specific EHW99_RS02630 ENOG4105DZY Pts system, glucitol sorbitol-specific EHW99_RS02635 ENOG4105VI0 Pts system, glucitol sorbitol-specific EHW99_RS02640 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase EHW99_RS02645 ENOG4105J92 DNA-binding transcriptional activator GutM EHW99_RS02650 ENOG410804X Transcriptional regulator EHW99_RS02655 ENOG4105C2X Arabinose 5-phosphate isomerase EHW99_RS02750 ENOG4105ETE Transcriptional regulator (LacI family EHW99_RS02775 ENOG4105BZU Histidine kinase EHW99_RS02780 ENOG4105YBH Protein of unknown function (DUF1435) EHW99_RS02800 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EHW99_RS02805 ENOG4108WPU DNA polymerase III subunit psi EHW99_RS02810 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EHW99_RS02815 ENOG4105PAD Hydrolase EHW99_RS02835 ENOG4106VK6 Flagellar motor protein EHW99_RS02865 ENOG4108WC9 type VI secretion system effector, hcp1 family EHW99_RS02925 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EHW99_RS02930 ENOG4105D9P serine threonine protein kinase EHW99_RS02965 ENOG4105CNA YD repeat protein EHW99_RS03000 ENOG41065RQ ADP-ribosylation crystallin J1 EHW99_RS03005 ENOG4108R3E Dna-3-methyladenine glycosylase i EHW99_RS03010 ENOG4105EXC Acyl-transferase EHW99_RS03015 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) EHW99_RS03020 ENOG4105K3G Periplasmic Protein EHW99_RS03030 ENOG4108NRW Phospholipase, patatin family EHW99_RS03035 ENOG4105EYA deoxyribonuclease EHW99_RS03040 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EHW99_RS03045 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EHW99_RS03050 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EHW99_RS03055 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EHW99_RS03060 ENOG4105EUP HipA domain protein EHW99_RS03065 ENOG41062Z9 Membrane EHW99_RS03070 ENOG4105EAC phosphoserine phosphatase EHW99_RS03075 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EHW99_RS03080 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase EHW99_RS03095 ENOG4105CIS alcohol dehydrogenase EHW99_RS03100 ENOG4105CC0 LysR family Transcriptional regulator EHW99_RS03105 ENOG4105C5H ABC transporter EHW99_RS03115 ENOG4107FB0 transcriptional regulator DeoR family EHW99_RS03125 ENOG4107SC1 transglycosylase EHW99_RS03130 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) EHW99_RS03135 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EHW99_RS03140 ENOG4105CVJ phosphoglycerate mutase EHW99_RS03150 ENOG4105UEI Transcriptional Regulator AraC Family EHW99_RS03155 ENOG4108RH0 Crea protein EHW99_RS03160 ENOG41065U4 response regulator EHW99_RS03175 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) EHW99_RS03185 ENOG4105D1Q UPF0246 protein EHW99_RS03195 ENOG4108RIR Molybdenum cofactor biosynthesis protein EHW99_RS03205 ENOG4105CFG Acts as a chaperone (By similarity) EHW99_RS03210 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EHW99_RS03215 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EHW99_RS03220 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) EHW99_RS03225 ENOG4105DTN riboflavin biosynthesis protein ribF EHW99_RS03230 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EHW99_RS03235 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EHW99_RS03240 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase EHW99_RS03245 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EHW99_RS03250 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EHW99_RS03255 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EHW99_RS03260 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EHW99_RS03265 ENOG4105CCF Lysine exporter protein (Lyse ygga) EHW99_RS03270 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) EHW99_RS03275 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EHW99_RS03280 ENOG4105NWN ApaG protein EHW99_RS03285 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EHW99_RS03290 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) EHW99_RS03305 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) EHW99_RS03310 ENOG4105D3G Pseudouridine synthase EHW99_RS03315 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) EHW99_RS03320 ENOG4105CQ2 DNA polymerase EHW99_RS03325 ENOG4108KF1 Membrane EHW99_RS03330 ENOG4107T0D ABC, transporter EHW99_RS03335 ENOG4106SMU thiamine transporter membrane protein EHW99_RS03340 ENOG4105DP9 ABC transporter EHW99_RS03345 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) EHW99_RS03350 ENOG4105S8Q sugar efflux transporter EHW99_RS03355 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EHW99_RS03360 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EHW99_RS03365 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EHW99_RS03370 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EHW99_RS03380 ENOG4105C7K acetolactate synthase EHW99_RS03385 ENOG4108ZP8 Acetolactate synthase small subunit EHW99_RS03390 ENOG4107B7Y DNA-binding transcriptional regulator FruR EHW99_RS03395 ENOG4108V6E Cell division protein mraZ EHW99_RS03400 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EHW99_RS03405 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) EHW99_RS03410 ENOG4105CJN penicillin-binding protein EHW99_RS03415 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EHW99_RS03420 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) EHW99_RS03425 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EHW99_RS03430 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EHW99_RS03435 ENOG4105CNI cell division protein FtsW EHW99_RS03440 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EHW99_RS03445 ENOG4105DFU Cell wall formation (By similarity) EHW99_RS03450 ENOG4105CPF Cell wall formation (By similarity) EHW99_RS03455 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) EHW99_RS03460 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EHW99_RS03465 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EHW99_RS03470 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EHW99_RS03480 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) EHW99_RS03485 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving EHW99_RS03495 ENOG4108M1A Chitin-binding protein EHW99_RS03520 ENOG4108RTD type II secretion system protein K EHW99_RS03530 ENOG4105X5Z General secretion pathway protein I EHW99_RS03545 ENOG4105D7Q type ii secretion system EHW99_RS03570 ENOG4105M6F mutator MutT protein EHW99_RS03575 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) EHW99_RS03580 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) EHW99_RS03590 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EHW99_RS03595 ENOG4105D7Q type ii secretion system EHW99_RS03600 ENOG4107QHF type ii secretion system protein e EHW99_RS03605 ENOG4108ZUW Major pilin subunit EHW99_RS03620 ENOG4106A72 regulatory protein AmpE EHW99_RS03645 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) EHW99_RS03650 ENOG4105CT4 transporter EHW99_RS03655 ENOG4105C85 amino acid EHW99_RS03660 ENOG41073TP transcriptional regulator EHW99_RS03665 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EHW99_RS03670 ENOG4107QSN dihydrolipoamide acetyltransferase EHW99_RS03675 ENOG4107QN2 dihydrolipoyl dehydrogenase EHW99_RS03680 ENOG4105CHR reductase EHW99_RS03685 ENOG4108JJB ABC transporter EHW99_RS03690 ENOG4107QCX Transporter EHW99_RS03695 ENOG4107ZYJ bioY protein EHW99_RS03710 ENOG4107F3J Amp-dependent synthetase and ligase EHW99_RS03715 ENOG4105CHU acetyl-coa acetyltransferase EHW99_RS03740 ENOG4105DTT CRISPR-associated helicase, cas3 EHW99_RS03745 ENOG4105CYR Crispr-associated protein, cse1 family EHW99_RS03750 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) EHW99_RS03755 ENOG41060M0 Crispr-associated protein, cse4 family EHW99_RS03760 ENOG4108VWQ crispr-associated protein EHW99_RS03765 ENOG4108Y7V CRISPR-associated protein, Cse3 family EHW99_RS03770 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) EHW99_RS03775 ENOG4105PWE CRISPR-associated protein cas2 EHW99_RS03790 ENOG4107QIJ Aconitate hydratase 2 EHW99_RS03795 ENOG4108ZIG UPF0231 protein EHW99_RS03800 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EHW99_RS03805 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EHW99_RS03810 ENOG4108ZRK uncharacterized protein yacC EHW99_RS03815 ENOG4105E3B Multicopper oxidase EHW99_RS03835 ENOG4108UGV hypoxanthine phosphoribosyltransferase EHW99_RS03840 ENOG41077A9 carbonic anhydrase EHW99_RS03845 ENOG4105DA5 (ABC) transporter EHW99_RS03850 ENOG4105E3A (ABC) transporter EHW99_RS03855 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EHW99_RS03860 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EHW99_RS03865 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EHW99_RS03870 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EHW99_RS03875 ENOG4105DJ0 Poly(A) Polymerase EHW99_RS03880 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) EHW99_RS03885 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters EHW99_RS03890 ENOG4105PW4 Sugar fermentation stimulation protein homolog EHW99_RS03895 ENOG4107XID 2'-5' rna ligase EHW99_RS03900 ENOG4105CQ7 ATP-dependent helicase EHW99_RS03905 ENOG4105BZ4 penicillin-binding protein EHW99_RS03915 ENOG4105CNA YD repeat protein EHW99_RS03935 ENOG4105K4U addiction module toxin, RelE StbE family EHW99_RS03950 ENOG4105E0A ABC, transporter EHW99_RS03955 ENOG4105J76 Periplasmic binding protein EHW99_RS03960 ENOG4105S6R Iron-hydroxamate transporter permease subunit EHW99_RS03965 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EHW99_RS03970 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EHW99_RS03980 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EHW99_RS03985 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein EHW99_RS03990 ENOG4105C0H protease EHW99_RS03995 ENOG4108T8E UPF0325 protein EHW99_RS04000 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) EHW99_RS04005 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) EHW99_RS04010 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EHW99_RS04015 ENOG4105CE9 30S ribosomal protein S2 EHW99_RS04020 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EHW99_RS04025 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EHW99_RS04030 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EHW99_RS04035 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EHW99_RS04040 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EHW99_RS04045 ENOG4105KNE Phosphatidate cytidylyltransferase EHW99_RS04050 ENOG4105DZP Membrane-associated zinc metalloprotease EHW99_RS04055 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EHW99_RS04060 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) EHW99_RS04065 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EHW99_RS04070 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EHW99_RS04075 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EHW99_RS04080 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EHW99_RS04085 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EHW99_RS04090 ENOG4105C0B DNA polymerase III (alpha subunit) EHW99_RS04095 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) EHW99_RS04100 ENOG4105CXN decarboxylase EHW99_RS04105 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EHW99_RS04110 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EHW99_RS04120 ENOG4105M1T rho-binding antiterminator EHW99_RS04130 ENOG4108VWS Yaeq family EHW99_RS04135 ENOG4108YZN class I peptide chain release factor EHW99_RS04145 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EHW99_RS04150 ENOG4108R96 Methyltransferase, YaeB family EHW99_RS04155 ENOG4108R8X outer membrane lipoprotein EHW99_RS04160 ENOG4105D01 (LipO)protein EHW99_RS04165 ENOG4108UMI ABC transporter, permease EHW99_RS04170 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EHW99_RS04175 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase EHW99_RS04205 ENOG4105CSH Transporter EHW99_RS04210 ENOG4105T42 (LipO)protein EHW99_RS04215 ENOG4105JIM Phosphatidylserine synthase EHW99_RS04220 ENOG4105CD5 CoA-binding domain protein EHW99_RS04225 ENOG4106IUH DTW domain containing protein EHW99_RS04230 ENOG4105K63 Thioredoxin EHW99_RS04235 ENOG4105EIB trna rrna methyltransferase EHW99_RS04240 ENOG4105C0R drug resistance transporter emrb qaca subfamily EHW99_RS04245 ENOG4105CW7 secretion protein, HlyD family EHW99_RS04250 ENOG4105NTK Transcriptional repressor Mpra EHW99_RS04255 ENOG4105EQ0 Major Facilitator superfamily EHW99_RS04260 ENOG4105GIJ Glycine betaine EHW99_RS04265 ENOG4108HQS Glycine betaine EHW99_RS04270 ENOG4108IJ7 Glycine betaine EHW99_RS04275 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EHW99_RS04280 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EHW99_RS04285 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EHW99_RS04290 ENOG4105WAZ (Glutaredoxin-like protein) NrdH EHW99_RS04295 ENOG4108WMJ Protein of unknown function (DUF2002) EHW99_RS04305 ENOG4108MK9 spermidine N(1)-acetyltransferase EHW99_RS04310 ENOG4105DRB nucleoside-specific channel-forming protein EHW99_RS04320 ENOG4105D7B Flagellar biosynthesis protein flha EHW99_RS04325 ENOG4105D00 flagellar biosynthetic protein flhB EHW99_RS04335 ENOG4108VYJ response regulator receiver protein EHW99_RS04345 ENOG4105BZU Histidine kinase EHW99_RS04350 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EHW99_RS04355 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EHW99_RS04360 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EHW99_RS04365 ENOG41090PJ Flagellar assembly protein EHW99_RS04370 ENOG4108JIR Flagellum-specific ATP synthase EHW99_RS04380 ENOG4105WF4 Flagellar hook-length control protein EHW99_RS04385 ENOG4107ZI8 flagellar basal body-associated protein flil EHW99_RS04390 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EHW99_RS04395 ENOG4105DD5 Flagellar motor switch protein EHW99_RS04400 ENOG4105K0P flagellar biosynthesis protein EHW99_RS04405 ENOG4105CN7 Flagellar biosynthetic protein FliP EHW99_RS04415 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EHW99_RS04420 ENOG4106R49 Methyltransferase EHW99_RS04450 ENOG4105DTS flagellar hook-associated EHW99_RS04455 ENOG4105MQ3 flagellar protein FliS EHW99_RS04465 ENOG4105QVD Flagella synthesis protein FlgN EHW99_RS04475 ENOG4105CKS Flagella basal body P-ring formation protein flgA EHW99_RS04480 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EHW99_RS04485 ENOG4108ZC9 flagellar basal-body rod protein flgc EHW99_RS04490 ENOG4105W00 Flagellar hook capping protein EHW99_RS04495 ENOG4105BZE flagellar hook protein, FlgE EHW99_RS04500 ENOG4108KPB Flagellar basal-body rod protein FlgF EHW99_RS04505 ENOG4105CGA flagellar basal-body rod protein FlgG EHW99_RS04510 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EHW99_RS04515 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EHW99_RS04520 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EHW99_RS04525 ENOG4105E1Q flagellar hook-associated protein EHW99_RS04530 ENOG4105DTJ flagellar hook-associated protein EHW99_RS04535 ENOG4105C8Q Methyl-accepting chemotaxis EHW99_RS04540 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EHW99_RS04545 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) EHW99_RS04550 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region EHW99_RS04555 ENOG4107RD7 Flagellar Motor Protein, MotA EHW99_RS04560 ENOG4105ER2 Ompa motb domain protein EHW99_RS04565 ENOG4105CBS Chea signal transduction histidine kinase EHW99_RS04570 ENOG4108V3W Chemotaxis protein, CheW EHW99_RS04580 ENOG4105E12 capsule polysaccharide EHW99_RS04595 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EHW99_RS04600 ENOG4108Z1B Cyclase dehydrase EHW99_RS04605 ENOG4105VDB UPF0125 protein EHW99_RS04610 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EHW99_RS04615 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EHW99_RS04620 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EHW99_RS04625 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EHW99_RS04630 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EHW99_RS04635 ENOG4105C1J atp-dependent rna helicase EHW99_RS04640 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) EHW99_RS04645 ENOG4108IYU L-aspartate oxidase EHW99_RS04650 ENOG4108IYU L-aspartate oxidase EHW99_RS04665 ENOG4105VQK sigma E regulatory protein, MucB RseB EHW99_RS04670 ENOG4105WMJ Positive regulator of sigma E, RseC MucC EHW99_RS04685 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EHW99_RS04690 ENOG4105C3F Signal peptidase i EHW99_RS04695 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EHW99_RS04700 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EHW99_RS04705 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) EHW99_RS04710 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) EHW99_RS04715 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) EHW99_RS04725 ENOG4106G6Q Transcriptional regulator EHW99_RS04730 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EHW99_RS04735 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB EHW99_RS04740 ENOG4108Z6B deaminase EHW99_RS04745 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) EHW99_RS04750 ENOG4108ETH Formylglycinamide ribotide synthetase EHW99_RS04755 ENOG4107WP9 Histidine kinase EHW99_RS04760 ENOG4108SKK alpha helix protein EHW99_RS04765 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EHW99_RS04770 ENOG4108YZA Nitrogen regulatory protein pii EHW99_RS04775 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EHW99_RS04780 ENOG4108MN2 Stationary phase inducible protein CsiE EHW99_RS04785 ENOG4105ECY inositol monophosphatase EHW99_RS04790 ENOG4105CVS RNA methyltransferase TrmH family, group 1 EHW99_RS04795 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family EHW99_RS04800 ENOG4105C3J Cysteine desulfurase EHW99_RS04805 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EHW99_RS04810 ENOG4105YYA enhanced serine sensitivity protein SseB EHW99_RS04815 ENOG4107QTZ amino acid EHW99_RS04820 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EHW99_RS04830 ENOG4105CTU Proline racemase EHW99_RS04850 ENOG4105CZJ Aldehyde dehydrogenase EHW99_RS04855 ENOG4105DG4 malate L-lactate dehydrogenase EHW99_RS04860 ENOG4105KHC sulfurtransferase EHW99_RS04865 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EHW99_RS04870 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EHW99_RS04880 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) EHW99_RS04885 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EHW99_RS04890 ENOG4105CUT histidyl-tRNA synthetase EHW99_RS04895 ENOG4105N21 Membrane EHW99_RS04900 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EHW99_RS04905 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EHW99_RS04915 ENOG4105DZG Dehydrogenase EHW99_RS04925 ENOG4105D4Y metalloprotease EHW99_RS04930 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EHW99_RS04935 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EHW99_RS04940 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EHW99_RS04970 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme EHW99_RS04975 ENOG4105D3G Pseudouridine synthase EHW99_RS04985 ENOG4105EXW epimerase dehydratase EHW99_RS04990 ENOG4105CSP Major Facilitator Superfamily EHW99_RS04995 ENOG4105CJW magnesium transporter EHW99_RS05000 ENOG4105BZU Histidine kinase EHW99_RS05005 ENOG41088CC tellurite resistance protein tehB EHW99_RS05010 ENOG4105C9X ppx gppa phosphatase EHW99_RS05015 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) EHW99_RS05020 ENOG4105C8U phosphate abc transporter EHW99_RS05025 ENOG4105E2Z phosphate ABC transporter (Permease EHW99_RS05030 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EHW99_RS05035 ENOG4108V3E phosphoribosylglycinamide formyltransferase EHW99_RS05040 ENOG4105CXB phosphoribosylaminoimidazole synthetase EHW99_RS05045 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EHW99_RS05050 ENOG4105C2W permease EHW99_RS05055 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) EHW99_RS05060 ENOG4105K89 arsenate reductase EHW99_RS05070 ENOG4105BZU Histidine kinase EHW99_RS05075 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EHW99_RS05080 ENOG4105RH4 Glycine cleavage system transcriptional repressor EHW99_RS05085 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EHW99_RS05090 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EHW99_RS05095 ENOG4105C8V SAICAR synthetase EHW99_RS05100 ENOG4105CGZ zinc metallopeptidase EHW99_RS05105 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) EHW99_RS05120 ENOG4105CNA YD repeat protein EHW99_RS05140 ENOG4105CNA YD repeat protein EHW99_RS05160 ENOG4105XYK UPF0370 protein EHW99_RS05165 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) EHW99_RS05170 ENOG4105KUZ arsenate reductase EHW99_RS05185 ENOG4105BZS acriflavin resistance protein EHW99_RS05190 ENOG4105WH1 Two component transcriptional regulator luxr family EHW99_RS05195 ENOG4105BZU Histidine kinase EHW99_RS05200 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction EHW99_RS05205 ENOG4105C85 amino acid EHW99_RS05210 ENOG4107VIJ nudix hydrolase EHW99_RS05215 ENOG4105CV1 Transketolase (EC 2.2.1.1) EHW99_RS05220 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EHW99_RS05225 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) EHW99_RS05230 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase EHW99_RS05240 ENOG4105QZU Inner membrane protein YfeZ EHW99_RS05245 ENOG4105E7K (LipO)protein EHW99_RS05250 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein EHW99_RS05255 ENOG4108I5D sulfate abc transporter EHW99_RS05260 ENOG4105ECW sulfate abc transporter EHW99_RS05265 ENOG4108IJ6 ABC transporter EHW99_RS05270 ENOG4105C6T cysteine synthase EHW99_RS05275 ENOG4105E3W Two component transcriptional regulator (Winged helix family EHW99_RS05280 ENOG4105E0F Histidine kinase EHW99_RS05285 ENOG4105C5Y PTS System EHW99_RS05290 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EHW99_RS05295 ENOG4105KZ7 phosphocarrier protein hpr EHW99_RS05300 ENOG4105C6T cysteine synthase EHW99_RS05305 ENOG4105EXN Sulfate transport protein CysZ EHW99_RS05310 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) EHW99_RS05315 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EHW99_RS05320 ENOG4105VRT cytoplasmic protein EHW99_RS05325 ENOG4105DHU Bile acid EHW99_RS05330 ENOG4108M0I Transcriptional regulator EHW99_RS05375 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EHW99_RS05380 ENOG4105HZG regulatoR EHW99_RS05385 ENOG4105TMB Formate nitrite transporter EHW99_RS05400 ENOG4105D9N nucleoside EHW99_RS05405 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EHW99_RS05415 ENOG4105CPC Aldo Keto reductase EHW99_RS05420 ENOG4107RA9 decarboxylase EHW99_RS05425 ENOG4105CHC glucokinase (EC 2.7.1.2) EHW99_RS05440 ENOG4105CHM Aminotransferase EHW99_RS05480 ENOG4105CUY Mechanosensitive ion channel EHW99_RS05490 ENOG4105BZU Histidine kinase EHW99_RS05515 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) EHW99_RS05520 ENOG41060IM Heme exporter protein EHW99_RS05525 ENOG4105X3C heme exporter protein EHW99_RS05530 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) EHW99_RS05535 ENOG4105DA4 cytochrome c-type biogenesis protein EHW99_RS05545 ENOG4105KWW Biogenesis protein EHW99_RS05550 ENOG4105KWW Biogenesis protein EHW99_RS05555 ENOG410903C (LipO)protein EHW99_RS05560 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation EHW99_RS05575 ENOG4105CHU acetyl-coa acetyltransferase EHW99_RS05580 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EHW99_RS05585 ENOG4108BY2 phosphohistidine phosphatase EHW99_RS05590 ENOG4108DG9 Smr protein MutS2 EHW99_RS05595 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) EHW99_RS05600 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EHW99_RS05610 ENOG4105EJ9 Membrane EHW99_RS05615 ENOG4108BPE -transporting atpase EHW99_RS05620 ENOG4105MH2 YfcL protein EHW99_RS05625 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) EHW99_RS05630 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EHW99_RS05665 ENOG4106WZ1 flagella biosynthesis regulator EHW99_RS05685 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EHW99_RS05695 ENOG4105DQR SNARE associated Golgi EHW99_RS05705 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) EHW99_RS05710 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EHW99_RS05715 ENOG4108S3P Sporulation domain protein EHW99_RS05720 ENOG4105E96 Colicin v production protein EHW99_RS05725 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EHW99_RS05730 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EHW99_RS05735 ENOG4105E89 ABC transporter EHW99_RS05740 ENOG4105DSP amino acid AbC transporter EHW99_RS05745 ENOG4106YG3 ABC transporter EHW99_RS05750 ENOG4108JEH abc transporter atp-binding protein EHW99_RS05755 ENOG4105ECP epimerase EHW99_RS05765 ENOG4105PTV Nudix Hydrolase EHW99_RS05770 ENOG4105D38 putrescine abc transporter EHW99_RS05775 ENOG4105F38 ABC transporter, permease EHW99_RS05785 ENOG4108JPW Aminotransferase EHW99_RS05795 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EHW99_RS05800 ENOG4105C6K Malic enzyme EHW99_RS05805 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EHW99_RS05810 ENOG4105PQ6 UPF0208 membrane protein EHW99_RS05815 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 EHW99_RS05835 ENOG4105DK2 UPF0207 protein EHW99_RS05840 ENOG4105CHM Aminotransferase EHW99_RS05845 ENOG4107NQ8 LysR family Transcriptional regulator EHW99_RS05850 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EHW99_RS05855 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EHW99_RS05860 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EHW99_RS05865 ENOG4105GKE subunit e EHW99_RS05870 ENOG4107QIZ NADH dehydrogenase EHW99_RS05875 ENOG4108IEH NADH dehydrogenase subunit g EHW99_RS05880 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) EHW99_RS05885 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EHW99_RS05890 ENOG4107UFS subunit j EHW99_RS05895 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EHW99_RS05900 ENOG4105D65 subunit l EHW99_RS05905 ENOG4105C8S subunit m EHW99_RS05910 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EHW99_RS05925 ENOG4107YB6 acetyltransferase, (GNAT) family EHW99_RS05930 ENOG4105DJ9 glucan biosynthesis protein EHW99_RS05935 ENOG4105TNS Conserved Protein EHW99_RS05940 ENOG4105DFH Transport of potassium into the cell (By similarity) EHW99_RS05950 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase EHW99_RS05970 ENOG4105XPH Ferredoxin EHW99_RS05975 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EHW99_RS05980 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EHW99_RS05985 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EHW99_RS05990 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EHW99_RS05995 ENOG4105BZU Histidine kinase EHW99_RS06000 ENOG41068CG regulatoR EHW99_RS06005 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC EHW99_RS06015 ENOG4105FCK Membrane EHW99_RS06025 ENOG4105CJ2 (LipO)protein EHW99_RS06030 ENOG4105CF1 Alkylated DNA repair protein EHW99_RS06040 ENOG4108TSE Transferase EHW99_RS06100 ENOG4105E68 Sulfatase EHW99_RS06105 ENOG4105YDX UPF0352 protein EHW99_RS06110 ENOG4106V8H Nucleoid-associated protein EHW99_RS06115 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EHW99_RS06120 ENOG4105CFI type iii restriction protein res subunit EHW99_RS06125 ENOG4105I08 Pseudouridine synthase EHW99_RS06130 ENOG4105C2C drug resistance transporter, Bcr CflA EHW99_RS06135 ENOG4105HG6 EHW99_RS06140 ENOG4108JQ5 ABC transporter EHW99_RS06145 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component EHW99_RS06150 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component EHW99_RS06155 ENOG4105E43 Extracellular solute-binding protein, family 5 EHW99_RS06160 ENOG4105CXC rtn protein EHW99_RS06165 ENOG4107TT5 NLP P60 protein EHW99_RS06170 ENOG41076MN Phosphoesterase, PA-phosphatase related EHW99_RS06175 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EHW99_RS06180 ENOG4105KRS Proteinase inhibitor EHW99_RS06185 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein EHW99_RS06190 ENOG4105DE4 1-phosphofructokinase EHW99_RS06195 ENOG4105DM4 PTS System EHW99_RS06200 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EHW99_RS06205 ENOG4105HMI Membrane EHW99_RS06210 ENOG4105DUM transcriptional regulator, lysR family EHW99_RS06215 ENOG4108IQI permease EHW99_RS06220 ENOG4105EHG Permease protein EHW99_RS06225 ENOG4105E0A ABC, transporter EHW99_RS06245 ENOG4105EGI Transcriptional regulator EHW99_RS06250 ENOG4105EUJ GTP cyclohydrolase i EHW99_RS06255 ENOG4105DHF Membrane EHW99_RS06260 ENOG41060NJ transcriptional regulator EHW99_RS06270 ENOG4105C2J ABC transporter EHW99_RS06275 ENOG4107SDZ Galactoside transport system permease protein mglC EHW99_RS06280 ENOG4107GZ4 SanA protein EHW99_RS06285 ENOG4107R1I NAD-dependent malic enzyme EHW99_RS06290 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) EHW99_RS06295 ENOG41067MG lrgb family EHW99_RS06305 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EHW99_RS06310 ENOG4105D1F ATP-binding protein EHW99_RS06325 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) EHW99_RS06335 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase EHW99_RS06340 ENOG4105DWF phosphomethylpyrimidine kinase EHW99_RS06345 ENOG4107TE5 Lipid kinase EHW99_RS06365 ENOG4105E3W Two component transcriptional regulator (Winged helix family EHW99_RS06370 ENOG4105EB3 Histidine kinase EHW99_RS06380 ENOG4105BZS acriflavin resistance protein EHW99_RS06395 ENOG4105R8A Heat shock protein EHW99_RS06400 ENOG4105BZU Histidine kinase EHW99_RS06405 ENOG4105MH5 phosphoesterase PA-phosphatase related protein EHW99_RS06410 ENOG4105DBI uridine monophosphokinase EHW99_RS06415 ENOG4105DHP deoxycytidine triphosphate deaminase EHW99_RS06420 ENOG4108GAE asmA family EHW99_RS06425 ENOG4105EE5 Membrane protein terC EHW99_RS06430 ENOG4105D3Q Sugar transferase EHW99_RS06435 ENOG4105DAY polysaccharide export protein EHW99_RS06440 ENOG4107ZF2 Phosphatase EHW99_RS06445 ENOG4105D75 Capsular exopolysaccharide family EHW99_RS06450 ENOG4105JEU Glycosyl transferase, family 2 EHW99_RS06460 ENOG4105CG5 Glycosyl transferase (Group 1 EHW99_RS06465 ENOG4108RYC glycosyltransferase EHW99_RS06475 ENOG4105C74 pyruvyl transferase EHW99_RS06480 ENOG4107T8Q Glycosyl transferase (Group 1 EHW99_RS06485 ENOG4105PSV Polysaccharide Biosynthesis Protein EHW99_RS06490 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EHW99_RS06495 ENOG4105CMR udp-glucose 4-epimerase EHW99_RS06550 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EHW99_RS06555 ENOG4108KXH Ybak prolyl-tRNA synthetase associated EHW99_RS06560 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EHW99_RS06565 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EHW99_RS06570 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EHW99_RS06575 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EHW99_RS06580 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EHW99_RS06585 ENOG4105CIH Imidazole acetol-phosphate transaminase EHW99_RS06595 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EHW99_RS06605 ENOG4107SRH Nad-dependent epimerase dehydratase EHW99_RS06610 ENOG4105CUB amino acid EHW99_RS06615 ENOG4105CJB Exodeoxyribonuclease I EHW99_RS06625 ENOG4105DR8 Membrane EHW99_RS06630 ENOG41090HJ UPF0265 protein EHW99_RS06635 ENOG4105UQX Mate efflux family protein EHW99_RS06640 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EHW99_RS06645 ENOG4105EV9 Alpha Beta Hydrolase EHW99_RS06665 ENOG41061WN bacilysin biosynthesis protein EHW99_RS06670 ENOG4105CM2 brancheD-chain amino acid aminotransferase EHW99_RS06690 ENOG4105F7P transcriptional regulator AsnC family EHW99_RS06700 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EHW99_RS06710 ENOG4105FYV Amp nucleosidase EHW99_RS06750 ENOG4107R11 Transcriptional regulator EHW99_RS06755 ENOG4105N14 lysine exporter protein LysE YggA EHW99_RS06780 ENOG4107WN4 Polygalacturonase EHW99_RS06800 ENOG4105DEF Extracellular solute-binding protein, family 5 EHW99_RS06805 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EHW99_RS06810 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EHW99_RS06815 ENOG4108JQ6 ABC transporter EHW99_RS06825 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase EHW99_RS06855 ENOG4105CC5 ABC transporter EHW99_RS06860 ENOG4105CC5 ABC transporter EHW99_RS06865 ENOG4105DIK (ABC) transporter EHW99_RS06870 ENOG4105DSE periplasmic solute binding protein EHW99_RS06875 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) EHW99_RS06890 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) EHW99_RS06900 ENOG4105EST Metal Dependent Phosphohydrolase EHW99_RS06905 ENOG4105WPN DNA integration recombination invertion protein EHW99_RS06915 ENOG41090BB DNA mismatch endonuclease (vsr) EHW99_RS06925 ENOG4105CKW Inner membrane protein yedI EHW99_RS06930 ENOG4105VNZ cytoplasmic protein EHW99_RS06940 ENOG4105JCU Inherit from NOG: (Lipo)protein EHW99_RS06945 ENOG4105E5K Alpha-amylase EHW99_RS06955 ENOG4105MQ3 flagellar protein FliS EHW99_RS06960 ENOG4105DTS flagellar hook-associated EHW99_RS06965 ENOG4105I03 Flagellin EHW99_RS06965 ENOG4105I03 Flagellin EHW99_RS06975 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EHW99_RS06980 ENOG4108M9K flagella biosynthesis protein FliZ EHW99_RS06990 ENOG4105IQC Inner membrane protein YcfT EHW99_RS06995 ENOG4105C26 Dehydrogenase EHW99_RS07000 ENOG4105CK7 Sodium proline symporter EHW99_RS07005 ENOG4105EKT )-iron permease EHW99_RS07015 ENOG4105DBE peroxidase EHW99_RS07020 ENOG4105D5M phosphate starvation-inducible protein EHW99_RS07035 ENOG4108DBC nitroreductase EHW99_RS07060 ENOG4107XHZ cytoplasmic chaperone TorD family protein EHW99_RS07070 ENOG4105C26 Dehydrogenase EHW99_RS07075 ENOG4105ETS cytosine purines uracil thiamine allantoin EHW99_RS07080 ENOG4105K64 Glycosyl transferase, family 2 EHW99_RS07085 ENOG4105ER6 polysaccharide biosynthesis protein EHW99_RS07095 ENOG4108YYH Nadph-dependent fmn reductase EHW99_RS07100 ENOG4105D52 delta-aminolevulinic acid dehydratase EHW99_RS07105 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EHW99_RS07110 ENOG4105KT5 UmuD protein EHW99_RS07120 ENOG4108K4C ec 3.1.3.12 EHW99_RS07125 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase EHW99_RS07130 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) EHW99_RS07135 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region EHW99_RS07140 ENOG4107RD7 Flagellar Motor Protein, MotA EHW99_RS07145 ENOG4105ER2 Ompa motb domain protein EHW99_RS07150 ENOG4105CBS Chea signal transduction histidine kinase EHW99_RS07155 ENOG4108V3W Chemotaxis protein, CheW EHW99_RS07160 ENOG4105C8Q Methyl-accepting chemotaxis EHW99_RS07175 ENOG4105BZU Histidine kinase EHW99_RS07180 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EHW99_RS07185 ENOG4108VYJ response regulator receiver protein EHW99_RS07195 ENOG4105D00 flagellar biosynthetic protein flhB EHW99_RS07200 ENOG4105D7B Flagellar biosynthesis protein flha EHW99_RS07205 ENOG4105W13 flagellar protein EHW99_RS07210 ENOG4105C75 arginyL-tRNA synthetase EHW99_RS07215 ENOG4106ZCM YecM protein EHW99_RS07220 ENOG4105C87 Aminotransferase class I and II EHW99_RS07225 ENOG4106N3A copper homeostasis protein cutc EHW99_RS07235 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) EHW99_RS07240 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) EHW99_RS07245 ENOG4105WJG Glutathione EHW99_RS07250 ENOG41081XQ Conserved Protein EHW99_RS07255 ENOG4105C9M aspartyl-trna synthetase EHW99_RS07260 ENOG4108TIT dATP pyrophosphohydrolase EHW99_RS07265 ENOG4105CDY transcriptional regulatory protein EHW99_RS07270 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) EHW99_RS07275 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EHW99_RS07280 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EHW99_RS07285 ENOG4105FAV ABC, transporter EHW99_RS07295 ENOG4105NXV High-affinity zinc uptake system protein EHW99_RS07300 ENOG4105DR5 peptidase EHW99_RS07305 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase EHW99_RS07315 ENOG4105CA9 Pyruvate kinase EHW99_RS07320 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EHW99_RS07325 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR EHW99_RS07330 ENOG4105X2V dna damage-inducible protein EHW99_RS07340 ENOG4105CUG Oligopeptidase b EHW99_RS07345 ENOG4105UMD exodeoxyribonuclease X EHW99_RS07350 ENOG4105MPK DNA polymerase III subunit theta EHW99_RS07370 ENOG4105NKT exported protein EHW99_RS07390 ENOG4105F4G Membrane EHW99_RS07405 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EHW99_RS07410 ENOG4105DY2 Paraquat-inducible protein b EHW99_RS07415 ENOG4105H2K paraquat-inducible protein a EHW99_RS07420 ENOG4108ZGC gaf domain protein EHW99_RS07425 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) EHW99_RS07430 ENOG4105CN1 protease EHW99_RS07435 ENOG4105D0M Protease HtpX homolog EHW99_RS07440 ENOG4105TIK EHW99_RS07445 ENOG4105Q3Y exported protein EHW99_RS07465 ENOG4105DHI Methyltransferase EHW99_RS07470 ENOG4105EE5 Membrane protein terC EHW99_RS07475 ENOG4105EJQ L-serine dehydratase EHW99_RS07480 ENOG4105P8F nudix hydrolase EHW99_RS07490 ENOG4105X5C UPF0181 protein EHW99_RS07495 ENOG4105M4H endoribonuclease L-psp EHW99_RS07500 ENOG4105DVT helicase EHW99_RS07505 ENOG41072GX Peptidase M22 Glycoprotease EHW99_RS07510 ENOG4105Y4Z Outer Membrane Lipoprotein EHW99_RS07515 ENOG4105CEY Amp-dependent synthetase and ligase EHW99_RS07525 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) EHW99_RS07530 ENOG4107QMS site-determining protein EHW99_RS07535 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EHW99_RS07540 ENOG4105VNG YcgL domain-containing protein EHW99_RS07545 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase EHW99_RS07550 ENOG4108ZZ3 UPF0260 protein EHW99_RS07555 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) EHW99_RS07560 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) EHW99_RS07565 ENOG4105ED1 spovr family EHW99_RS07570 ENOG4105MWK D-amino acid dehydrogenase, small subunit EHW99_RS07575 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EHW99_RS07585 ENOG4105D3Q Sugar transferase EHW99_RS07600 ENOG4106AKX UPF0229 protein EHW99_RS07605 ENOG4105CYN Serine protein kinase EHW99_RS07610 ENOG4105GNX MltA-interacting MipA family protein EHW99_RS07615 ENOG4105CV8 reductase EHW99_RS07620 ENOG4105DSB aldose 1-epimerase EHW99_RS07630 ENOG4105E0X reductase EHW99_RS07635 ENOG4105VUT cytoplasmic protein EHW99_RS07640 ENOG4108RWI nicotinamidase EHW99_RS07645 ENOG4105HDK L-asparaginase EHW99_RS07650 ENOG4105D07 Signal peptide peptidase, SppA EHW99_RS07655 ENOG41069NU Nitroreductase EHW99_RS07660 ENOG4108IYH Dna topoisomerase EHW99_RS07665 ENOG4105MTM Protein of unknown function (DUF1496) EHW99_RS07670 ENOG4105CGK Exodeoxyribonuclease III EHW99_RS07705 ENOG4105CIY formyltetrahydrofolate deformylase EHW99_RS07710 ENOG4105K5B UPF0225 protein EHW99_RS07715 ENOG4105I93 response regulator EHW99_RS07720 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EHW99_RS07725 ENOG4105C6Y Udp-glucose 6-dehydrogenase EHW99_RS07775 ENOG4105JSC dimethylmenaquinone methyltransferase EHW99_RS07785 ENOG4107F9Y LysR family transcriptional regulator EHW99_RS07790 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EHW99_RS07805 ENOG4105D2S major facilitator superfamily EHW99_RS07815 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EHW99_RS07820 ENOG4108J59 Extracellular solute-binding protein, family 5 EHW99_RS07825 ENOG4107QSI ABC, transporter EHW99_RS07830 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EHW99_RS07835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EHW99_RS07840 ENOG4105C3U ABC transporter EHW99_RS07845 ENOG4108JQ7 (ABC) transporter EHW99_RS07850 ENOG4108W5H UPF0263 protein EHW99_RS07855 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EHW99_RS07870 ENOG4105K9H YciI-like protein EHW99_RS07875 ENOG410822N TonB family EHW99_RS07880 ENOG4105NAU thioesterase Superfamily protein EHW99_RS07885 ENOG4107835 probably involved in intracellular septation (By similarity) EHW99_RS07895 ENOG4105EIF outer membrane protein W EHW99_RS07905 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EHW99_RS07910 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EHW99_RS07915 ENOG4105DK0 Indole-3-glycerol phosphate synthase EHW99_RS07920 ENOG4108I0Q anthranilate phosphoribosyltransferase EHW99_RS07925 ENOG4108EFP Anthranilate synthase component II EHW99_RS07930 ENOG4105CRQ synthase (Component I) EHW99_RS07935 ENOG4105DB7 PHP domain protein EHW99_RS07940 ENOG4107RTD sua5 ycio yrdc ywlc family protein EHW99_RS07950 ENOG4105UBK short-chain dehydrogenase reductase EHW99_RS07955 ENOG4105ERU peptidase EHW99_RS07960 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EHW99_RS07965 ENOG4107R11 Transcriptional regulator EHW99_RS07980 ENOG4107QM5 aconitate hydratase EHW99_RS07990 ENOG4105EYK Phosphatidylglycerophosphatase B EHW99_RS07995 ENOG4105Q4A inner membrane protein yciS EHW99_RS08000 ENOG4105CFV Tetratricopeptide repeat protein EHW99_RS08005 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EHW99_RS08010 ENOG4108ZJT translation initiation factor, Sui1 EHW99_RS08025 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EHW99_RS08030 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) EHW99_RS08035 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit EHW99_RS08060 ENOG4105DUM transcriptional regulator, lysR family EHW99_RS08065 ENOG4105Q4T oxidoreductase EHW99_RS08075 ENOG4108JQ2 peptide transport system atp-binding protein EHW99_RS08080 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein EHW99_RS08085 ENOG4108EU3 peptide transport system, permease EHW99_RS08090 ENOG4108I5W peptide transport system, permease protein EHW99_RS08095 ENOG4108J59 Extracellular solute-binding protein, family 5 EHW99_RS08100 ENOG4105E51 psp operon transcriptional activator EHW99_RS08105 ENOG41087YS Phage shock protein A EHW99_RS08110 ENOG4105YYT phage shock protein B EHW99_RS08115 ENOG4105FM1 phage shock protein C EHW99_RS08120 ENOG4105NNG Peripheral inner membrane phage-shock protein EHW99_RS08125 ENOG4105CM6 amino acid regulated cytosolic protein EHW99_RS08130 ENOG4106K28 UPF0283 membrane protein EHW99_RS08140 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EHW99_RS08145 ENOG4107S8C mandelate racemase muconate lactonizing EHW99_RS08150 ENOG4107QSI ABC, transporter EHW99_RS08170 ENOG4105E6S usher protein( EHW99_RS08175 ENOG4108S1B Periplasmic chaperone protein EHW99_RS08180 ENOG4105UMR response to DNA damage stimulus EHW99_RS08195 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) EHW99_RS08205 ENOG4105C1J atp-dependent rna helicase EHW99_RS08220 ENOG4105C5I Dehydrogenase EHW99_RS08225 ENOG4107H52 Dicarboxylate transport EHW99_RS08230 ENOG410689M (LipO)protein EHW99_RS08235 ENOG4105WXT Conserved Protein EHW99_RS08240 ENOG4108BAS reductase EHW99_RS08245 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EHW99_RS08250 ENOG4105CQ7 ATP-dependent helicase EHW99_RS08255 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EHW99_RS08260 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap EHW99_RS08270 ENOG4105CTD carboxy-peptidase EHW99_RS08275 ENOG4105JJR Histidine kinase EHW99_RS08280 ENOG4107R08 Integrase EHW99_RS08335 ENOG4107EXC regulatoR EHW99_RS08345 ENOG4105D5Q Arginine ornithine antiporter EHW99_RS08350 ENOG4105C5D exported protein EHW99_RS08360 ENOG4105S5I Membrane EHW99_RS08375 ENOG4105Q9Y Universal stress protein EHW99_RS08385 ENOG4108DG9 Smr protein MutS2 EHW99_RS08405 ENOG4105D2S major facilitator superfamily EHW99_RS08415 ENOG4105C8Q Methyl-accepting chemotaxis EHW99_RS08425 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EHW99_RS08430 ENOG4105DEF Extracellular solute-binding protein, family 5 EHW99_RS08435 ENOG4108JU7 Transcriptional regulator EHW99_RS08440 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) EHW99_RS08445 ENOG4105FBW Monooxygenase EHW99_RS08465 ENOG4107T8P acyl-Coa dehydrogenase EHW99_RS08470 ENOG4105F27 Major Facilitator EHW99_RS08480 ENOG4105UEI Transcriptional Regulator AraC Family EHW99_RS08495 ENOG4105GGE ribonuclease EHW99_RS08515 ENOG4107SCK Monooxygenase EHW99_RS08540 ENOG4105DWT malate dehydrogenase (quinone) EHW99_RS08550 ENOG4107B2H carbonic anhydrase EHW99_RS08555 ENOG4105C8Q Methyl-accepting chemotaxis EHW99_RS08570 ENOG4105CH6 catalase EHW99_RS08585 ENOG41061RM osmotically inducible lipoprotein EHW99_RS08605 ENOG4105YA8 Transcriptional regulator EHW99_RS08630 ENOG4105RKW reductase (By EHW99_RS08635 ENOG4105D82 Glutamate dehydrogenase EHW99_RS08645 ENOG4108VMM UPF0756 membrane protein EHW99_RS08655 ENOG41061H0 Monooxygenase EHW99_RS08660 ENOG4105DGW oligopeptidase A EHW99_RS08665 ENOG4107QUY Guanine deaminase EHW99_RS08670 ENOG4105EMU Dehydrogenase EHW99_RS08675 ENOG4105M5Q UPF0482 protein EHW99_RS08685 ENOG4105C0R drug resistance transporter emrb qaca subfamily EHW99_RS08690 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EHW99_RS08695 ENOG4105DAG ROK family EHW99_RS08700 ENOG4106NZI LysR family Transcriptional regulator EHW99_RS08705 ENOG4105D94 Major Facilitator Superfamily EHW99_RS08715 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) EHW99_RS08720 ENOG4105C9Q fumarate hydratase class II EHW99_RS08725 ENOG4106J39 exported protein EHW99_RS08730 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) EHW99_RS08735 ENOG4105D9R oxidoreductase EHW99_RS08745 ENOG4105CNN ABC, transporter EHW99_RS08755 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator EHW99_RS08760 ENOG4105EF1 ribulokinase EHW99_RS08765 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) EHW99_RS08770 ENOG4105M9B inner membrane protein ydgK EHW99_RS08775 ENOG4105DGN Electron transport complex EHW99_RS08780 ENOG4108R3D Electron transport complex EHW99_RS08785 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) EHW99_RS08790 ENOG4105D6A Electron transport complex EHW99_RS08795 ENOG4108UQQ Electron transport complex EHW99_RS08800 ENOG4105DZB Electron transport complex EHW99_RS08805 ENOG4105CSM endonuclease III EHW99_RS08820 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EHW99_RS08830 ENOG4108K3A Glutathione S-transferase EHW99_RS08840 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) EHW99_RS08845 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EHW99_RS08850 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) EHW99_RS08855 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) EHW99_RS08860 ENOG4108XTF Outer Membrane Lipoprotein EHW99_RS08875 ENOG4105XZD Fe-S protein EHW99_RS08895 ENOG4105DIJ Phosphoethanolamine transferase EHW99_RS08905 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EHW99_RS08910 ENOG4108UYE Lactoylglutathione lyase EHW99_RS08915 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) EHW99_RS08920 ENOG4105M2J Glutaredoxin EHW99_RS08925 ENOG4105K4H Nlp p60 protein EHW99_RS08930 ENOG4105ETE Transcriptional regulator (LacI family EHW99_RS08935 ENOG4105F52 Transcriptional regulator EHW99_RS08940 ENOG4105CZQ inner membrane transport protein YdhC EHW99_RS08945 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EHW99_RS08950 ENOG4108R6K riboflavin synthase, subunit alpha EHW99_RS08955 ENOG4107QI1 Mate efflux family protein EHW99_RS08970 ENOG4105CA9 Pyruvate kinase EHW99_RS08980 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) EHW99_RS08990 ENOG4105JRK feS assembly protein SufD EHW99_RS08995 ENOG4105C3K feS assembly ATPase SufC EHW99_RS09000 ENOG4105DIW FeS assembly protein SUFB EHW99_RS09005 ENOG4108Z4V iron-sulfur cluster assembly EHW99_RS09015 ENOG4105CQB FAD linked oxidase domain protein EHW99_RS09020 ENOG4105IPI Membrane EHW99_RS09030 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EHW99_RS09035 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EHW99_RS09045 ENOG4106QJH hemin transport protein EHW99_RS09050 ENOG4107R4I Periplasmic binding protein EHW99_RS09055 ENOG4105EHG Permease protein EHW99_RS09060 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) EHW99_RS09065 ENOG4105CNG UPF0061 protein EHW99_RS09080 ENOG4108QBX (LipO)protein EHW99_RS09085 ENOG4108V06 Glutathione peroxidase EHW99_RS09095 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EHW99_RS09105 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EHW99_RS09115 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EHW99_RS09120 ENOG41082NX 50s ribosomal protein l35 EHW99_RS09130 ENOG4105C22 threonyL-tRNA synthetase EHW99_RS09135 ENOG4108NE3 Salt-induced outer membrane protein EHW99_RS09140 ENOG4105P10 Uncharacterized protein ydiZ EHW99_RS09150 ENOG4107PN8 YfeABCD locus regulator EHW99_RS09155 ENOG4107K5X Membrane-bound metal-dependent hydrolase EHW99_RS09160 ENOG4108ETY sodium dicarboxylate symporter EHW99_RS09170 ENOG4105KKI DNA-binding transcriptional activator OsmE EHW99_RS09175 ENOG4105C2C drug resistance transporter, Bcr CflA EHW99_RS09180 ENOG4107RA1 nh(3)-dependent nad( ) synthetase EHW99_RS09185 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) EHW99_RS09190 ENOG4108SPG Periplasmic Protein EHW99_RS09195 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) EHW99_RS09200 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) EHW99_RS09205 ENOG4105C26 Dehydrogenase EHW99_RS09210 ENOG4105F4X arginine EHW99_RS09215 ENOG4105C8Y Acetylornithine aminotransferase EHW99_RS09220 ENOG4105FCK Membrane EHW99_RS09225 ENOG4105ID0 Putative invasin EHW99_RS09255 ENOG4108NH8 Cation transport protein EHW99_RS09275 ENOG4108HKT sucrose-6-phosphate hydrolase EHW99_RS09280 ENOG4105WBN Transcriptional regulator (LacI family EHW99_RS09285 ENOG4105EWV Sodium calcium exchanger membrane region EHW99_RS09290 ENOG41090X5 Heat shock protein hslJ EHW99_RS09295 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EHW99_RS09300 ENOG41063JG Transcriptional regulator EHW99_RS09305 ENOG4108YY7 Invasion gene expression up-regulator SirB EHW99_RS09310 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EHW99_RS09315 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EHW99_RS09320 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EHW99_RS09325 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) EHW99_RS09330 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EHW99_RS09335 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EHW99_RS09340 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria EHW99_RS09345 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EHW99_RS09355 ENOG4105CHH sulfate transporter EHW99_RS09360 ENOG4105C3G gtp-binding protein EHW99_RS09370 ENOG410854A Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EHW99_RS09380 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC EHW99_RS09395 ENOG4108Z19 type iii secretion EHW99_RS09400 ENOG4108M6W surface presentation of antigens protein SpaS EHW99_RS09405 ENOG4108TN6 type iii secretion EHW99_RS09410 ENOG4105U07 type iii secretion EHW99_RS09415 ENOG41075IY surface presentation of antigens protein SpaP EHW99_RS09435 ENOG4108JIR Flagellum-specific ATP synthase EHW99_RS09445 ENOG4108HR8 type iii secretion EHW99_RS09460 ENOG4105YY8 Transcriptional regulator EHW99_RS09470 ENOG4105Y7Q type iii secretion EHW99_RS09475 ENOG4106BTR EHW99_RS09500 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component EHW99_RS09510 ENOG4105M5B (LipO)protein EHW99_RS09515 ENOG4105M5B (LipO)protein EHW99_RS09520 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EHW99_RS09525 ENOG4108MRH transcriptional regulatory protein EHW99_RS09545 ENOG4107GFK fumarate EHW99_RS09560 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EHW99_RS09570 ENOG4105Y3U Transglycosylase-associated protein EHW99_RS09575 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) EHW99_RS09580 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) EHW99_RS09585 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division EHW99_RS09590 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EHW99_RS09600 ENOG4105Y50 Virulence Protein EHW99_RS09630 ENOG4108HMX isocitrate dehydrogenase (NADP) EHW99_RS09635 ENOG4108R99 pseudouridine synthase EHW99_RS09645 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EHW99_RS09650 ENOG41075W9 High frequency lysogenization protein HflD homolog EHW99_RS09655 ENOG4107QTF adenylosuccinate lyase EHW99_RS09660 ENOG4105XJC Two component transcriptional regulator (Winged helix family EHW99_RS09670 ENOG4105EZE Cupin 4 family protein EHW99_RS09675 ENOG4108JCI Transcriptional regulator EHW99_RS09680 ENOG4105DKK Benzoate EHW99_RS09685 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EHW99_RS09690 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) EHW99_RS09700 ENOG4105D60 lipoprotein releasing system transmembrane protein EHW99_RS09705 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EHW99_RS09710 ENOG4105D60 lipoprotein releasing system transmembrane protein EHW99_RS09715 ENOG4105BZU Histidine kinase EHW99_RS09740 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EHW99_RS09745 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EHW99_RS09750 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EHW99_RS09755 ENOG41090PJ Flagellar assembly protein EHW99_RS09760 ENOG4108JIR Flagellum-specific ATP synthase EHW99_RS09765 ENOG4105GSA Flagellar export protein flij EHW99_RS09770 ENOG4105WF4 Flagellar hook-length control protein EHW99_RS09775 ENOG4107ZI8 flagellar basal body-associated protein flil EHW99_RS09780 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EHW99_RS09785 ENOG4105DD5 Flagellar motor switch protein EHW99_RS09790 ENOG4105K0P flagellar biosynthesis protein EHW99_RS09795 ENOG4105CN7 Flagellar biosynthetic protein FliP EHW99_RS09800 ENOG4105VS8 Flagellar biosynthetic protein fliq EHW99_RS09805 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EHW99_RS09830 ENOG4105C3Q Glycosyl transferase, family 2 EHW99_RS09835 ENOG4108JA2 transcriptioN-repair coupling factor EHW99_RS09840 ENOG4107MBR 17 kDa surface antigen EHW99_RS09845 ENOG4105CEP NADH dehydrogenase EHW99_RS09855 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) EHW99_RS09865 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) EHW99_RS09875 ENOG4105K59 histidine triad (HIT) protein EHW99_RS09880 ENOG4105CI1 PTS System EHW99_RS09885 ENOG4105F8V Hydrolase, tatD family EHW99_RS09890 ENOG4107QRG dna polymerase iii EHW99_RS09895 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EHW99_RS09900 ENOG4105HHA aminodeoxychorismate lyase EHW99_RS09905 ENOG4105YAZ 4-amino-4-deoxychorismate lyase EHW99_RS09910 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EHW99_RS09915 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EHW99_RS09920 ENOG4105CHR reductase EHW99_RS09925 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EHW99_RS09930 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EHW99_RS09935 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EHW99_RS09940 ENOG4105VGS 50s ribosomal protein l32 EHW99_RS09945 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein EHW99_RS09950 ENOG4108UHJ MAF-like protein EHW99_RS09955 ENOG4105EI2 Pseudouridine synthase EHW99_RS09960 ENOG4107QQB Ribonuclease E EHW99_RS09960 ENOG4107QQB Ribonuclease E EHW99_RS09965 ENOG4105DTJ flagellar hook-associated protein EHW99_RS09970 ENOG4105E1Q flagellar hook-associated protein EHW99_RS09975 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EHW99_RS09980 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) EHW99_RS09990 ENOG4105CGA flagellar basal-body rod protein FlgG EHW99_RS09995 ENOG4108KPB Flagellar basal-body rod protein FlgF EHW99_RS10000 ENOG4105BZE flagellar hook protein, FlgE EHW99_RS10005 ENOG4105W00 Flagellar hook capping protein EHW99_RS10010 ENOG4108ZC9 flagellar basal-body rod protein flgc EHW99_RS10015 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EHW99_RS10020 ENOG4105CKS Flagella basal body P-ring formation protein flgA EHW99_RS10025 ENOG4105M9M anti-sigma28 factor FlgM EHW99_RS10030 ENOG4105QVD Flagella synthesis protein FlgN EHW99_RS10035 ENOG4105CJR Integral membrane protein (MviN EHW99_RS10045 ENOG4105D9U N-acetyltransferase EHW99_RS10050 ENOG4105E9S glutaredoxin 2 EHW99_RS10055 ENOG4105F3T (LipO)protein EHW99_RS10060 ENOG4105EKE dihydroorotase EHW99_RS10065 ENOG4105MEA DNA damage-inducible protein i EHW99_RS10070 ENOG4105PVA Biofilm formation regulatory protein BssS EHW99_RS10075 ENOG4105F76 Sarcosine oxidase EHW99_RS10080 ENOG4105DS1 cytochrome b561 EHW99_RS10090 ENOG4105C72 UPF0176 protein EHW99_RS10095 ENOG4105D1S lipid A biosynthesis EHW99_RS10100 ENOG4108W47 Acidic protein msyB EHW99_RS10105 ENOG4105NAC (LipO)protein EHW99_RS10110 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) EHW99_RS10125 ENOG4107RZC phospholipase d EHW99_RS10140 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EHW99_RS10155 ENOG41067TZ transcriptional regulator, MarR family EHW99_RS10180 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EHW99_RS10185 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EHW99_RS10190 ENOG4105WH1 Two component transcriptional regulator luxr family EHW99_RS10195 ENOG4105XVG cytoplasmic protein EHW99_RS10200 ENOG4105RA2 Membrane EHW99_RS10210 ENOG4105VJY transcriptional regulator EHW99_RS10215 ENOG4105C85 amino acid EHW99_RS10225 ENOG4108R86 Transcriptional regulator EHW99_RS10235 ENOG4105XH3 EHW99_RS10240 ENOG4105C26 Dehydrogenase EHW99_RS10245 ENOG4105D6F Phosphatase EHW99_RS10265 ENOG4108MN8 Membrane EHW99_RS10270 ENOG4108Z0T Part of a sulfur-relay system (By similarity) EHW99_RS10275 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 EHW99_RS10280 ENOG4105DR4 Methyltransferase EHW99_RS10285 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) EHW99_RS10295 ENOG4108Z5K methylglyoxal synthase EHW99_RS10300 ENOG41088T4 Helicase IV EHW99_RS10305 ENOG410901E Membrane EHW99_RS10310 ENOG4105EM2 membrane EHW99_RS10315 ENOG4108RZ1 DNA transformation protein EHW99_RS10330 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) EHW99_RS10335 ENOG4105DAN ATP-dependent protease EHW99_RS10340 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) EHW99_RS10345 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) EHW99_RS10350 ENOG4108Q2G (LipO)protein EHW99_RS10355 ENOG4105DY2 Paraquat-inducible protein b EHW99_RS10360 ENOG4105F1S paraquat-inducible protein a EHW99_RS10365 ENOG4105C5H ABC transporter EHW99_RS10370 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EHW99_RS10375 ENOG4105QVC MOSC domain-containing protein EHW99_RS10380 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) EHW99_RS10385 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) EHW99_RS10390 ENOG4108UZX fmn reductase EHW99_RS10395 ENOG4105GVF (ABC) transporter EHW99_RS10405 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EHW99_RS10415 ENOG4105CD8 aminopeptidase N EHW99_RS10420 ENOG4107RH7 Nicotinate phosphoribosyltransferase EHW99_RS10425 ENOG4105C5S asparaginyl-tRNA synthetase EHW99_RS10435 ENOG4105CGF Aromatic amino acid aminotransferase EHW99_RS10440 ENOG4105C5X domain protein EHW99_RS10445 ENOG4105EAQ (twin-arginine translocation) pathway signal EHW99_RS10450 ENOG4105DIT ErfK YbiS YcfS YnhG family protein EHW99_RS10455 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) EHW99_RS10460 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) EHW99_RS10465 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) EHW99_RS10470 ENOG4106371 Methyltransferase EHW99_RS10475 ENOG4107S90 membrAne EHW99_RS10480 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) EHW99_RS10485 ENOG4105W49 UPF0434 protein EHW99_RS10490 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) EHW99_RS10495 ENOG4105BZ1 (ABC) transporter EHW99_RS10500 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 EHW99_RS10505 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) EHW99_RS10510 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EHW99_RS10515 ENOG4105CAT Cytidine monophosphate kinase EHW99_RS10520 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EHW99_RS10525 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EHW99_RS10530 ENOG4105DDY UPF0142 protein ycaO EHW99_RS10540 ENOG4108ISG Major Facilitator EHW99_RS10545 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EHW99_RS10550 ENOG4105D1H recombination factor protein RarA EHW99_RS10555 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) EHW99_RS10560 ENOG4105CNU cell division protein FtsK EHW99_RS10565 ENOG4105EW9 transcriptional regulator AsnC family EHW99_RS10570 ENOG4105C3M thioredoxin reductase EHW99_RS10575 ENOG4108JJ9 ABC, transporter EHW99_RS10580 ENOG4108JJ8 (ABC) transporter EHW99_RS10585 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) EHW99_RS10595 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EHW99_RS10600 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) EHW99_RS10610 ENOG4105VEQ Cold shock protein EHW99_RS10615 ENOG4105CPB ATP-dependent endonuclease of the OLD family EHW99_RS10620 ENOG4105C7K acetolactate synthase EHW99_RS10625 ENOG4105C5W Aldolase EHW99_RS10635 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EHW99_RS10640 ENOG4105K8R UPF0145 protein EHW99_RS10645 ENOG41064MM (LipO)protein EHW99_RS10650 ENOG4105E5Z arginine transporter ATP-binding subunit EHW99_RS10655 ENOG4106PMH Extracellular solute-binding protein family 3 EHW99_RS10660 ENOG4105GBT ABC transporter EHW99_RS10665 ENOG4105DMR ABC, transporter EHW99_RS10670 ENOG4106TNF Periplasmic binding protein EHW99_RS10675 ENOG4105RBQ inner membrane protein ybjO EHW99_RS10680 ENOG4105D38 putrescine abc transporter EHW99_RS10685 ENOG4105F38 ABC transporter, permease EHW99_RS10690 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EHW99_RS10695 ENOG4107RUE extracellular solute-binding protein family 1 EHW99_RS10700 ENOG4108RMJ sensory transduction regulator EHW99_RS10705 ENOG4108DBC nitroreductase EHW99_RS10715 ENOG41090BQ Glutaredoxin EHW99_RS10730 ENOG4105C44 Serine transporter EHW99_RS10735 ENOG4105DZ1 carboxypeptidase EHW99_RS10755 ENOG4108JQ6 ABC transporter EHW99_RS10760 ENOG4105D44 asparaginase EHW99_RS10765 ENOG4105CVM Molybdenum cofactor synthesis domain protein EHW99_RS10770 ENOG4105D06 uba thif-type nad fad binding protein EHW99_RS10775 ENOG4105C5H ABC transporter EHW99_RS10780 ENOG4107QNK )-transporter EHW99_RS10790 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EHW99_RS10795 ENOG4105C0R drug resistance transporter emrb qaca subfamily EHW99_RS10800 ENOG4105CW7 secretion protein, HlyD family EHW99_RS10805 ENOG4105KST dependent repressor EHW99_RS10810 ENOG4108T1M outer membrane protein x EHW99_RS10820 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction EHW99_RS10825 ENOG4105KSC Transcriptional regulator, TraR DksA family EHW99_RS10830 ENOG4107R0W ABC transporter EHW99_RS10835 ENOG4105E5Q amino acid AbC transporter EHW99_RS10840 ENOG4105CDA abc transporter atp-binding protein EHW99_RS10850 ENOG4105D8X mechanosensitive ion channel EHW99_RS10855 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) EHW99_RS10865 ENOG4105C4X radical SAM domain protein EHW99_RS10880 ENOG4105EW6 flavin reductase domain protein, FMN-binding EHW99_RS10885 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C EHW99_RS10895 ENOG4105CI2 imidazolone-5-propionate hydrolase EHW99_RS10900 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EHW99_RS10905 ENOG41090B9 response to stress EHW99_RS10910 ENOG4105CZE histidine utilization repressor EHW99_RS10915 ENOG4105C84 Histidine ammonia-lyase EHW99_RS10920 ENOG4105CGP Urocanate hydratase EHW99_RS10925 ENOG4105CH2 amidohydrolase EHW99_RS10930 ENOG4108MTB glycosyl transferase family EHW99_RS10935 ENOG4105DVT helicase EHW99_RS10950 ENOG4108XDN Transcriptional regulator EHW99_RS10960 ENOG4105EMU Dehydrogenase EHW99_RS10975 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EHW99_RS10995 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) EHW99_RS11005 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EHW99_RS11010 ENOG4105CXG d-lactate dehydrogenase EHW99_RS11020 ENOG4105EGS Mechanosensitive ion channel EHW99_RS11025 ENOG41061WM D-Alanyl-D-Alanine EHW99_RS11030 ENOG41069YE inner membrane protein yohC EHW99_RS11035 ENOG4105KHU inner membrane protein YohD EHW99_RS11040 ENOG4105BZP glycoside hydrolase 15-related EHW99_RS11045 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EHW99_RS11050 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) EHW99_RS11055 ENOG4105C1J atp-dependent rna helicase EHW99_RS11065 ENOG4105HFZ Membrane EHW99_RS11070 ENOG4107QS8 (LipO)protein EHW99_RS11075 ENOG4108ZAF Molybdopterin EHW99_RS11080 ENOG4105M00 molybdopterin converting factor, subunit 1 EHW99_RS11085 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EHW99_RS11090 ENOG4108RIR Molybdenum cofactor biosynthesis protein EHW99_RS11095 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EHW99_RS11100 ENOG4105CHW UPF0052 protein EHW99_RS11105 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EHW99_RS11110 ENOG4108IV0 ABC, transporter EHW99_RS11115 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EHW99_RS11125 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EHW99_RS11130 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EHW99_RS11135 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EHW99_RS11140 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EHW99_RS11145 ENOG4108V1U phospholipid-binding protein EHW99_RS11150 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EHW99_RS11155 ENOG4108K4B hydrolase EHW99_RS11165 ENOG4105E0C molybdate abc transporter EHW99_RS11170 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EHW99_RS11180 ENOG4105F4R Transcriptional regulator mode EHW99_RS11185 ENOG4105DKW ABC transporter EHW99_RS11190 ENOG4105F0Z galactose-1-phosphate uridylyltransferase EHW99_RS11195 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) EHW99_RS11200 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EHW99_RS11205 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) EHW99_RS11225 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EHW99_RS11230 ENOG4105JND homeobox protein EHW99_RS11235 ENOG4105PGM cation diffusion facilitator family transporter EHW99_RS11240 ENOG4106Z1T Nicotinamide Mononucleotide Transporter EHW99_RS11300 ENOG4105UFD tol-pal system protein YbgF EHW99_RS11305 ENOG4105KCK Peptidoglycan-associated lipoprotein EHW99_RS11310 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) EHW99_RS11315 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA EHW99_RS11325 ENOG4105E02 MotA TolQ exbB proton channel EHW99_RS11330 ENOG4107YD3 Thioesterase EHW99_RS11335 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EHW99_RS11340 ENOG4105CMV Succinyl-CoA synthetase subunit beta EHW99_RS11345 ENOG4105C7S Dehydrogenase EHW99_RS11350 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EHW99_RS11355 ENOG4105E33 succinate dehydrogenase EHW99_RS11360 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) EHW99_RS11365 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein EHW99_RS11370 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit EHW99_RS11375 ENOG4105BZN citrate synthase EHW99_RS11385 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) EHW99_RS11390 ENOG4105E7W lamb ycsf family protein EHW99_RS11395 ENOG4107R7A Allophanate hydrolase subunit 2 EHW99_RS11400 ENOG4105P4J Allophanate hydrolase, subunit 1 EHW99_RS11405 ENOG4107QNR UPF0135 protein EHW99_RS11410 ENOG4105CVP deoxyribo-dipyrimidine photolyase EHW99_RS11415 ENOG4107SEY Conserved Protein EHW99_RS11420 ENOG4105XIQ Protein of unknown function (DUF2517) EHW99_RS11425 ENOG4105EEX Two component transcriptional regulator (Winged helix family EHW99_RS11430 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 EHW99_RS11440 ENOG4105EV9 Alpha Beta Hydrolase EHW99_RS11445 ENOG4105NNH LexA regulated protein EHW99_RS11450 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) EHW99_RS11455 ENOG41090R7 Ferric uptake EHW99_RS11460 ENOG4105CIC tryptophan-specific transport protein EHW99_RS11465 ENOG4105CX6 glutaminyL-tRNA synthetase EHW99_RS11470 ENOG4105CI1 PTS System EHW99_RS11475 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EHW99_RS11480 ENOG4105CE4 GlcNAc 6-P deacetylase EHW99_RS11485 ENOG4105E2R ROK family EHW99_RS11490 ENOG4105D4U had-superfamily hydrolase, subfamily iia EHW99_RS11495 ENOG4105CAQ asparagine synthetase EHW99_RS11530 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EHW99_RS11535 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EHW99_RS11540 ENOG4105C9A Phoh family EHW99_RS11545 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EHW99_RS11550 ENOG4108JU5 Magnesium and cobalt efflux protein EHW99_RS11555 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EHW99_RS11560 ENOG4107RP9 extracellular solute-binding protein, family 3 EHW99_RS11565 ENOG4105EAD ABC transporter EHW99_RS11570 ENOG4105DRP amino acid AbC transporter EHW99_RS11575 ENOG4105CDA abc transporter atp-binding protein EHW99_RS11580 ENOG4107PAI alpha helical protein EHW99_RS11585 ENOG4105C8T Leucyl-tRNA synthetase EHW99_RS11590 ENOG4108U2H Rare lipoprotein B EHW99_RS11595 ENOG4105DJF DNA polymerase III, delta' subunit EHW99_RS11605 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) EHW99_RS11610 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EHW99_RS11615 ENOG4105CJN penicillin-binding protein EHW99_RS11620 ENOG4105CNI cell division protein FtsW EHW99_RS11625 ENOG4105K6T rare lipoprotein A EHW99_RS11630 ENOG4105DZ1 carboxypeptidase EHW99_RS11635 ENOG4108Z43 UPF0250 protein EHW99_RS11640 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) EHW99_RS11645 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) EHW99_RS11650 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) EHW99_RS11665 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) EHW99_RS11670 ENOG4105C6Z Gluconate EHW99_RS11675 ENOG4105C6Z Gluconate EHW99_RS11680 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EHW99_RS11685 ENOG4105FB2 class II Aldolase EHW99_RS11690 ENOG4105G63 Type III effector Hrp-dependent EHW99_RS11695 ENOG4105ZXK Dehydrogenase EHW99_RS11700 ENOG4105MVE transcriptional regulator EHW99_RS11715 ENOG4105C4M (Ubiquinol oxidase) subunit I EHW99_RS11720 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EHW99_RS11735 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) EHW99_RS11740 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) EHW99_RS11745 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) EHW99_RS11750 ENOG4105C3I Nad-dependent epimerase dehydratase EHW99_RS11755 ENOG4105CKK Glycosyl transferase, family 2 EHW99_RS11760 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EHW99_RS11765 ENOG41069ZX EHW99_RS11770 ENOG4105DZG Dehydrogenase EHW99_RS11775 ENOG4105CHB tonB-dependent Receptor EHW99_RS11790 ENOG4108JQ5 ABC transporter EHW99_RS11795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EHW99_RS11810 ENOG4105C3R Methionine synthase EHW99_RS11825 ENOG4108Z9K Osmotically inducible protein EHW99_RS11850 ENOG4108KU3 Integrase EHW99_RS11860 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EHW99_RS11865 ENOG4105WQ3 Rna-binding protein EHW99_RS11870 ENOG4105DQ4 alcohol dehydrogenase EHW99_RS11875 ENOG4105C8N cysteinyl-tRNA synthetase EHW99_RS11880 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EHW99_RS11890 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EHW99_RS11895 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EHW99_RS11900 ENOG4105CV6 ABC transporter, permease EHW99_RS11905 ENOG4108I0Y (ABC) transporter EHW99_RS11910 ENOG4108UJV acyl-CoA thioesterase i EHW99_RS11935 ENOG4105E1F short-chain dehydrogenase reductase EHW99_RS11940 ENOG4107QR8 Thioredoxin EHW99_RS11945 ENOG4107QX8 SPFH domain, Band 7 family protein EHW99_RS11950 ENOG4105G5H Membrane EHW99_RS11955 ENOG4108Z6Z Transcriptional regulator EHW99_RS11960 ENOG4105C59 p-type ATPase EHW99_RS11965 ENOG4105MBR gumn family EHW99_RS11970 ENOG4108Z66 YbaK ebsC protein EHW99_RS11975 ENOG4105C5Q Transcriptional regulator EHW99_RS11985 ENOG4105CGH 5'-nucleotidase EHW99_RS11990 ENOG4105EU0 Major facilitator Superfamily EHW99_RS11995 ENOG4105CKD glutathione-regulated potassium-efflux system protein EHW99_RS12005 ENOG4107RE1 Inosine-guanosine kinase EHW99_RS12010 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EHW99_RS12015 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EHW99_RS12040 ENOG4105DZ2 Transcriptional regulator EHW99_RS12045 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EHW99_RS12050 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EHW99_RS12055 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EHW99_RS12060 ENOG4107QMP dna polymerase iii subunits gamma and tau EHW99_RS12065 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EHW99_RS12070 ENOG4105WD1 Membrane EHW99_RS12085 ENOG4106428 Protein of unknown function (DUF2496) EHW99_RS12090 ENOG4107XI7 Tetr family transcriptional regulator EHW99_RS12095 ENOG4105C1P efflux transporter, rnd family, mfp subunit EHW99_RS12100 ENOG4105BZS acriflavin resistance protein EHW99_RS12105 ENOG4105NRA 50s ribosomal protein l31 type b EHW99_RS12110 ENOG4105YK5 50S ribosomal protein L36 EHW99_RS12120 ENOG4108UKR Biofilm formation regulator YbaJ EHW99_RS12135 ENOG41080UX Methyltransferase EHW99_RS12140 ENOG4108MNP Glycoprotein polysaccharide metabolism EHW99_RS12145 ENOG4105C29 acyl-CoA thioesterase EHW99_RS12150 ENOG4105BZU Histidine kinase EHW99_RS12155 ENOG4108YZA Nitrogen regulatory protein pii EHW99_RS12160 ENOG4105BZ1 (ABC) transporter EHW99_RS12165 ENOG4105BZ1 (ABC) transporter EHW99_RS12170 ENOG4108XM1 transcriptional regulator AsnC family EHW99_RS12175 ENOG4105DWP Membrane EHW99_RS12180 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EHW99_RS12185 ENOG4108TGP Thioesterase superfamily protein EHW99_RS12190 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein EHW99_RS12195 ENOG4105EIN peptidylprolyl cis-trans isomerase EHW99_RS12200 ENOG4105K70 DNA-binding protein EHW99_RS12205 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EHW99_RS12215 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EHW99_RS12230 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EHW99_RS12235 ENOG4105M85 Bola protein EHW99_RS12240 ENOG4105IEY (LipO)protein EHW99_RS12245 ENOG4105EYM Major Facilitator superfamily EHW99_RS12250 ENOG4105E2S oxidase) subunit II EHW99_RS12255 ENOG4105BZ9 Cytochrome C oxidase, subunit I EHW99_RS12260 ENOG4105CCU oxidase (Subunit III) EHW99_RS12265 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) EHW99_RS12270 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EHW99_RS12275 ENOG4107RDB Major Facilitator EHW99_RS12280 ENOG4108VPT UPF0234 protein EHW99_RS12285 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EHW99_RS12290 ENOG4107S0N DJ-1 family EHW99_RS12295 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EHW99_RS12300 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EHW99_RS12305 ENOG4105CTB Polyprenyl synthetase EHW99_RS12310 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EHW99_RS12315 ENOG4108ZAI phosphatidylglycerophosphatase a EHW99_RS12320 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EHW99_RS12325 ENOG4107YIM Involved in the transcription termination process (By similarity) EHW99_RS12330 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EHW99_RS12335 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EHW99_RS12340 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EHW99_RS12345 ENOG4109066 lysm domain bon superfamily protein EHW99_RS12355 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EHW99_RS12360 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EHW99_RS12365 ENOG4105VIE preprotein translocase, subunit YajC EHW99_RS12370 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EHW99_RS12375 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) EHW99_RS12380 ENOG4105CKK Glycosyl transferase, family 2 EHW99_RS12390 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EHW99_RS12395 ENOG4108ZYK Acyl carrier protein phosphodiesterase EHW99_RS12400 ENOG4105D3R alkyl hydroperoxide reductase EHW99_RS12405 ENOG4105C85 amino acid EHW99_RS12410 ENOG4105CWM branched-chain amino acid transport system II carrier protein EHW99_RS12420 ENOG4105DJH phosphate EHW99_RS12425 ENOG4105BZU Histidine kinase EHW99_RS12430 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EHW99_RS12435 ENOG4107RH8 nuclease SbcCD subunit D EHW99_RS12440 ENOG4105EYH Exonuclease EHW99_RS12445 ENOG4107Y60 (LipO)protein EHW99_RS12455 ENOG4106B0W Curli production assembly transport component CsgG EHW99_RS12480 ENOG4105DH7 May be involved in recombination (By similarity) EHW99_RS12485 ENOG4105NBK UPF0345 protein EHW99_RS12490 ENOG4105HBA AroM protein EHW99_RS12510 ENOG4105SS3 EHW99_RS12515 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EHW99_RS12520 ENOG4105G4C Periplasmic ligand-binding sensor protein EHW99_RS12525 ENOG4108UPT UPF0178 protein EHW99_RS12530 ENOG4105II7 pyrroline-5-carboxylate reductase EHW99_RS12540 ENOG4105VIF phosphate starvation-inducible protein EHW99_RS12545 ENOG4105CNT hydrolase family 2 EHW99_RS12570 ENOG4105DEF Extracellular solute-binding protein, family 5 EHW99_RS12575 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EHW99_RS12580 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EHW99_RS12590 ENOG4108JQ7 (ABC) transporter EHW99_RS12630 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) EHW99_RS12645 ENOG41082CG Protein CrcB homolog EHW99_RS12650 ENOG4105WD1 Membrane EHW99_RS12655 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EHW99_RS12660 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EHW99_RS12675 ENOG4105V1F Fermentation respiration switch protein EHW99_RS12680 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) EHW99_RS12685 ENOG4105CIN aminoacyl-histidine dipeptidase EHW99_RS12690 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EHW99_RS12695 ENOG4105F7V ErfK ybiS ycfS ynhG family protein EHW99_RS12700 ENOG4105E7A Glutamine amidotransferase EHW99_RS12705 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) EHW99_RS12710 ENOG4107QPN acyl-Coa dehydrogenase EHW99_RS12715 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) EHW99_RS12720 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EHW99_RS12725 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EHW99_RS12730 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) EHW99_RS12735 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) EHW99_RS12750 ENOG4105CHM Aminotransferase EHW99_RS12755 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EHW99_RS12760 ENOG4105C2W permease EHW99_RS12765 ENOG4105VT2 5-hydroxyisourate hydrolase EHW99_RS12780 ENOG4105C5R Aminotransferase EHW99_RS12790 ENOG4105E5Q amino acid AbC transporter EHW99_RS12795 ENOG4105DRP amino acid AbC transporter EHW99_RS12815 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EHW99_RS12835 ENOG4106H3A restriction EHW99_RS12840 ENOG4107QMH DNA methylase EHW99_RS12855 ENOG410633P Hydantoin racemase EHW99_RS12865 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EHW99_RS12875 ENOG4107RZZ dna polymerase iii epsilon subunit EHW99_RS12880 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EHW99_RS12885 ENOG4105D1A Methyltransferase EHW99_RS12890 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EHW99_RS12895 ENOG4105E9H Lytic Murein transglycosylase EHW99_RS12905 ENOG4107NA1 Endonuclease Exonuclease phosphatase EHW99_RS12940 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EHW99_RS12945 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EHW99_RS12950 ENOG4105C34 Pseudouridine synthase EHW99_RS12955 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EHW99_RS12960 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA EHW99_RS12975 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EHW99_RS12995 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EHW99_RS13010 ENOG4105K5M 30s ribosomal protein S16 EHW99_RS13015 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY EHW99_RS13020 ENOG4106KVJ cytochrome C assembly protein EHW99_RS13025 ENOG4108JU6 CBS domain protein EHW99_RS13035 ENOG4105D9M gamma-glutamylcysteine synthetase EHW99_RS13040 ENOG4105W39 Membrane EHW99_RS13045 ENOG4107VXZ Hydrolase EHW99_RS13070 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EHW99_RS13075 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EHW99_RS13080 ENOG4105Y3E Modulates RecA activity (By similarity) EHW99_RS13085 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EHW99_RS13090 ENOG4107TH8 cina domain protein EHW99_RS13095 ENOG4105CVE Lytic murein transglycosylase EHW99_RS13100 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly EHW99_RS13105 ENOG4108Z33 Thiol disulfide Interchange Protein EHW99_RS13120 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EHW99_RS13140 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE EHW99_RS13155 ENOG4108TN6 type iii secretion EHW99_RS13160 ENOG4105U07 type iii secretion EHW99_RS13165 ENOG41075IY surface presentation of antigens protein SpaP EHW99_RS13185 ENOG4108JIR Flagellum-specific ATP synthase EHW99_RS13195 ENOG4108HR8 type iii secretion EHW99_RS13200 ENOG4108N8R Invasion protein EHW99_RS13220 ENOG4105Y7Q type iii secretion EHW99_RS13225 ENOG4106BTR EHW99_RS13260 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EHW99_RS13265 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EHW99_RS13270 ENOG4108K5P (LipO)protein EHW99_RS13275 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) EHW99_RS13280 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) EHW99_RS13285 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) EHW99_RS13290 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EHW99_RS13295 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EHW99_RS13300 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) EHW99_RS13305 ENOG4105N0Z inner membrane protein ygbE EHW99_RS13310 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) EHW99_RS13315 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) EHW99_RS13320 ENOG4105C11 sulfate adenylyltransferase), subunit 2 EHW99_RS13325 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EHW99_RS13335 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EHW99_RS13340 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) EHW99_RS13345 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EHW99_RS13350 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase EHW99_RS13360 ENOG4105DRP amino acid AbC transporter EHW99_RS13365 ENOG4105CDA abc transporter atp-binding protein EHW99_RS13370 ENOG4105EAB amino acid AbC transporter EHW99_RS13375 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EHW99_RS13380 ENOG4105EXC Acyl-transferase EHW99_RS13385 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EHW99_RS13390 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EHW99_RS13395 ENOG4105DXN mazG family EHW99_RS13400 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EHW99_RS13405 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EHW99_RS13410 ENOG4105BZU Histidine kinase EHW99_RS13415 ENOG4105BZW Glycerate kinase EHW99_RS13420 ENOG4105QDK Flavodoxin EHW99_RS13425 ENOG4105DR9 pseudouridine synthase EHW99_RS13430 ENOG4105WP7 tRNA pseudouridine synthase C EHW99_RS13435 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) EHW99_RS13440 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EHW99_RS13445 ENOG4105EWT decarboxylase family EHW99_RS13450 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease EHW99_RS13455 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) EHW99_RS13460 ENOG4105M08 Membrane EHW99_RS13465 ENOG4105ETT transcriptional Regulator, LysR family EHW99_RS13470 ENOG4105M5B (LipO)protein EHW99_RS13475 ENOG4105C9B Cysteine desulfurase EHW99_RS13480 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) EHW99_RS13485 ENOG4105CUZ uba thif-type nad fad binding protein EHW99_RS13490 ENOG4105CA3 membrane-bound lytic murein transglycosylase EHW99_RS13510 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EHW99_RS13515 ENOG4107QZM n-acetylglutamate synthase EHW99_RS13525 ENOG4107QYX exodeoxyribonuclease v alpha EHW99_RS13530 ENOG4107QKA exodeoxyribonuclease V beta EHW99_RS13535 ENOG4107QXK peptidase EHW99_RS13540 ENOG4105DSY exodeoxyribonuclease V, gamma EHW99_RS13555 ENOG4105JCS prepilin peptidase dependent protein EHW99_RS13565 ENOG4108UQS dipeptidase EHW99_RS13570 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EHW99_RS13575 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EHW99_RS13580 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase EHW99_RS13585 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EHW99_RS13590 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) EHW99_RS13595 ENOG4105EE5 Membrane protein terC EHW99_RS13600 ENOG4105SUV lipoprotein YgdR EHW99_RS13605 ENOG4105CPC Aldo Keto reductase EHW99_RS13610 ENOG4107S74 Lysophospholipid transporter LplT EHW99_RS13615 ENOG4105CEY Amp-dependent synthetase and ligase EHW99_RS13640 ENOG4105BZS acriflavin resistance protein EHW99_RS13650 ENOG4105CJN penicillin-binding protein EHW99_RS13655 ENOG4105D5K Hemolysin activator protein EHW99_RS13660 ENOG4105CKT filamentous hemagglutinin EHW99_RS13675 ENOG41067NU EHW99_RS13690 ENOG41067NU EHW99_RS13705 ENOG4105CKT filamentous hemagglutinin EHW99_RS13720 ENOG41067NU EHW99_RS13725 ENOG4105H38 Membrane EHW99_RS13735 ENOG41060NJ transcriptional regulator EHW99_RS13745 ENOG4105RQF LysR family Transcriptional regulator EHW99_RS13750 ENOG4105F27 Major Facilitator EHW99_RS13760 ENOG4105CRK lysyL-tRNA synthetase EHW99_RS13770 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EHW99_RS13775 ENOG4105T95 Thiol disulfide interChange protein EHW99_RS13780 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EHW99_RS13785 ENOG4108NR7 pectate lyase EHW99_RS13790 ENOG4105DXC membrane EHW99_RS13795 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) EHW99_RS13800 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB EHW99_RS13805 ENOG4105Y75 tpr repeat protein EHW99_RS13810 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) EHW99_RS13815 ENOG4108UT2 hemolysin iii EHW99_RS13825 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EHW99_RS13830 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EHW99_RS13835 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EHW99_RS13840 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EHW99_RS13845 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EHW99_RS13850 ENOG4105D0A hydroxylase EHW99_RS13855 ENOG4107RAQ aminopeptidase EHW99_RS13860 ENOG4105E07 UPF0149 protein EHW99_RS13865 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) EHW99_RS13875 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EHW99_RS13880 ENOG4108JQ1 Dehydrogenase EHW99_RS13890 ENOG4105E66 phosphoriboisomerase A EHW99_RS13895 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) EHW99_RS13900 ENOG4105MPN Membrane EHW99_RS13930 ENOG4105H3G oxidoreductase EHW99_RS13945 ENOG4105D64 Mechanosensitive ion channel EHW99_RS13950 ENOG4105D2N Aldolase EHW99_RS13955 ENOG4105BZA Phosphoglycerate kinase EHW99_RS13960 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EHW99_RS13965 ENOG4105CV1 Transketolase (EC 2.2.1.1) EHW99_RS13970 ENOG4108K0D peptidase, M48 EHW99_RS13975 ENOG4105C8Q Methyl-accepting chemotaxis EHW99_RS14000 ENOG4105CYW agmatinase EHW99_RS14010 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) EHW99_RS14015 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EHW99_RS14020 ENOG4107QNK )-transporter EHW99_RS14025 ENOG4105GPY SprT protein EHW99_RS14030 ENOG4105RWS endonuclease I EHW99_RS14035 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EHW99_RS14040 ENOG4105D7Z glutathione synthase EHW99_RS14045 ENOG4108UJU UPF0301 protein EHW99_RS14050 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EHW99_RS14060 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EHW99_RS14075 ENOG4105CZX twitching motility protein EHW99_RS14080 ENOG4105DFA alanine racemase domain protein EHW99_RS14085 ENOG4108VIA integral membrane protein EHW99_RS14090 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EHW99_RS14095 ENOG4105CSA Coproporphyrinogen iii oxidase EHW99_RS14100 ENOG4105K33 Periplasmic Protein EHW99_RS14105 ENOG41090ED Protein with unknown function (DUF469) EHW99_RS14115 ENOG4105CEN a g-specific adenine glycosylase EHW99_RS14120 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) EHW99_RS14125 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division EHW99_RS14135 ENOG4105CXN decarboxylase EHW99_RS14200 ENOG4105NVB glycoside hydrolase, family 19 EHW99_RS14215 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EHW99_RS14220 ENOG4106P55 Transcriptional regulator EHW99_RS14235 ENOG4108E16 pectate lyase EHW99_RS14295 ENOG4107Y59 type iii secretion EHW99_RS14325 ENOG4105WH1 Two component transcriptional regulator luxr family EHW99_RS14335 ENOG4105I6B RNA polymerase EHW99_RS14345 ENOG4108HR8 type iii secretion EHW99_RS14375 ENOG4108HHI Type III secretion system protein EHW99_RS14405 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase EHW99_RS14410 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase EHW99_RS14430 ENOG4108WN0 inhibitor of vertebrate lysozyme EHW99_RS14435 ENOG41066YJ Beta-lactamase EHW99_RS14445 ENOG4105D22 carbon starvation protein EHW99_RS14450 ENOG4105VCD cytoplasmic protein EHW99_RS14455 ENOG4108NEV two component transcriptional regulator, LytTR family EHW99_RS14460 ENOG4108HRK Histidine kinase EHW99_RS14480 ENOG4105F7P transcriptional regulator AsnC family EHW99_RS14505 ENOG4105DDV Transcriptional regulator (LacI family EHW99_RS14515 ENOG4105CK1 PTS System EHW99_RS14520 ENOG4105VCP PTS System EHW99_RS14525 ENOG4105CS2 ec 3.2.1.21 EHW99_RS14530 ENOG4105CS2 ec 3.2.1.21 EHW99_RS14545 ENOG4105RXK Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) EHW99_RS14555 ENOG41090A1 ferritin EHW99_RS14565 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EHW99_RS14585 ENOG4105GSJ Inner membrane protein ylaC EHW99_RS14590 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EHW99_RS14620 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EHW99_RS14625 ENOG4105CSH Transporter EHW99_RS14630 ENOG4108ZZF transport protein (ExbD) EHW99_RS14635 ENOG4105CWK Biopolymer transport protein, ExbB EHW99_RS14640 ENOG4105C28 cystathionine EHW99_RS14645 ENOG4108K81 inner membrane protein YghB EHW99_RS14650 ENOG4105DY8 decarboxylase EHW99_RS14655 ENOG4108JPW Aminotransferase EHW99_RS14660 ENOG4105CF7 AraC family transcriptional regulator EHW99_RS14665 ENOG4105CV8 reductase EHW99_RS14670 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) EHW99_RS14675 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase EHW99_RS14680 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EHW99_RS14685 ENOG4105F87 Dehydratase EHW99_RS14730 ENOG4105C0W non-ribosomal peptide synthetase EHW99_RS14745 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) EHW99_RS14765 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EHW99_RS14770 ENOG4105IPS esterase EHW99_RS14775 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EHW99_RS14780 ENOG4108SX3 cytoplasmic protein EHW99_RS14785 ENOG41087AY ADP-Ribose pyrophosphatase EHW99_RS14790 ENOG4105DFG type I secretion outer membrane protein EHW99_RS14795 ENOG4105F1G UPF0441 protein EHW99_RS14800 ENOG4106032 Glutathionylspermidine synthase EHW99_RS14805 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EHW99_RS14810 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EHW99_RS14815 ENOG4105W0Z cytoplasmic protein EHW99_RS14820 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) EHW99_RS14825 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) EHW99_RS14830 ENOG4105I7R Adenylate cyclase EHW99_RS14835 ENOG4106MWK domain protein EHW99_RS14840 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EHW99_RS14845 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EHW99_RS14850 ENOG4107ZVW dihydroneopterin aldolase EHW99_RS14855 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EHW99_RS14860 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EHW99_RS14870 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EHW99_RS14875 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EHW99_RS14880 ENOG4108VCA G U mismatch-specific DNA glycosylase EHW99_RS14895 ENOG4107R6D beta-lactam binding protein AmpH EHW99_RS14900 ENOG4105HVQ Regulatory factor of maltose metabolism EHW99_RS14910 ENOG4105D01 (LipO)protein EHW99_RS14915 ENOG4106RHG Yeca family EHW99_RS14920 ENOG4108IJ6 ABC transporter EHW99_RS14950 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures EHW99_RS14955 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles EHW99_RS14960 ENOG4108XS9 dna repair protein EHW99_RS15010 ENOG4106H3A restriction EHW99_RS15040 ENOG4105RI1 glycoprotein receptor EHW99_RS15045 ENOG4105D7A ATP-binding protein EHW99_RS15050 ENOG4106BRA Membrane EHW99_RS15055 ENOG4108K5H permease YjgP YjgQ family protein EHW99_RS15060 ENOG4108M8S permease YjgP YjgQ family protein EHW99_RS15065 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EHW99_RS15070 ENOG4105MYG DNA polymerase iii, chi subunit EHW99_RS15075 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EHW99_RS15085 ENOG4105CXY transporter EHW99_RS15100 ENOG4108MJ3 acetyltransferase EHW99_RS15105 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) EHW99_RS15110 ENOG4105DBV ornithine carbamoyltransferase EHW99_RS15115 ENOG4105CXT aspartate transcarbamylase EHW99_RS15120 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) EHW99_RS15125 ENOG4105KME endoribonuclease L-psp EHW99_RS15130 ENOG4105E2D ec 3.2.1.52 EHW99_RS15135 ENOG4105C0D helicase EHW99_RS15145 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) EHW99_RS15150 ENOG4105Z6B inner membrane protein yjfl EHW99_RS15155 ENOG41082IR Excinuclease ABC C subunit domain protein EHW99_RS15160 ENOG4108YYD acetyltransferase EHW99_RS15165 ENOG4105DEN Luciferase family EHW99_RS15170 ENOG4105C1J atp-dependent rna helicase EHW99_RS15185 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EHW99_RS15190 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EHW99_RS15195 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EHW99_RS15200 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EHW99_RS15205 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EHW99_RS15210 ENOG4105CHV Transcription elongation factor NusA EHW99_RS15215 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EHW99_RS15230 ENOG4105NTZ Preprotein translocase subunit SecG EHW99_RS15235 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EHW99_RS15240 ENOG4105EEI dihydropteroate synthase EHW99_RS15245 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EHW99_RS15250 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) EHW99_RS15255 ENOG4105HBR Rna-binding protein EHW99_RS15260 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EHW99_RS15265 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase EHW99_RS15280 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EHW99_RS15290 ENOG4105K46 50S ribosomal protein l27 EHW99_RS15295 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EHW99_RS15300 ENOG4105EAH synthase EHW99_RS15305 ENOG4105HVQ Regulatory factor of maltose metabolism EHW99_RS15310 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EHW99_RS15315 ENOG4105VFK BolA family EHW99_RS15320 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane EHW99_RS15325 ENOG4105E3I toluene tolerance EHW99_RS15330 ENOG4107PE3 Mammalian cell entry related domain protein EHW99_RS15335 ENOG4105CY3 ABC transporter, permease EHW99_RS15340 ENOG4105DHJ ABC, transporter EHW99_RS15345 ENOG4105FEU K -dependent Na -Ca exchanger EHW99_RS15350 ENOG4105C2X Arabinose 5-phosphate isomerase EHW99_RS15355 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase EHW99_RS15360 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) EHW99_RS15365 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA EHW99_RS15370 ENOG4108IUZ ABC transporter EHW99_RS15375 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EHW99_RS15380 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA EHW99_RS15385 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN EHW99_RS15390 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EHW99_RS15395 ENOG41080Z8 PHOSPHOCARRIER protein EHW99_RS15400 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase EHW99_RS15405 ENOG4105BZU Histidine kinase EHW99_RS15410 ENOG4105CBC glutamate synthase EHW99_RS15415 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EHW99_RS15420 ENOG4105KB2 stringent starvation protein b EHW99_RS15425 ENOG4107MKT Stringent starvation protein a EHW99_RS15430 ENOG4108UJD 30S ribosomal protein S9 EHW99_RS15435 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EHW99_RS15440 ENOG4105D6Z AFG1 family ATPase EHW99_RS15445 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III EHW99_RS15450 ENOG4105C0H protease EHW99_RS15455 ENOG4105C0H protease EHW99_RS15460 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EHW99_RS15465 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) EHW99_RS15470 ENOG4105RID UPF0379 protein yhcN EHW99_RS15475 ENOG4105RID UPF0379 protein yhcN EHW99_RS15480 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) EHW99_RS15485 ENOG4105Y49 secretion protein, HlyD family EHW99_RS15490 ENOG4105ZQC membrane protein AaeX EHW99_RS15495 ENOG4105CR8 Transcriptional regulator EHW99_RS15500 ENOG4105D1U peptidase U62 modulator of DNA gyrase EHW99_RS15505 ENOG4105QD6 exported protein EHW99_RS15510 ENOG4105C03 ribonuclease EHW99_RS15515 ENOG4108Z03 MAF-like protein EHW99_RS15520 ENOG4105VQ7 Rod shape-determining protein MreD EHW99_RS15525 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EHW99_RS15535 ENOG41062P1 Diguanylate cyclase phosphodiesterase EHW99_RS15540 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family EHW99_RS15545 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) EHW99_RS15550 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) EHW99_RS15555 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EHW99_RS15560 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EHW99_RS15565 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EHW99_RS15570 ENOG4105RG0 Membrane EHW99_RS15575 ENOG4108IA2 Sodium pantothenate symporter EHW99_RS15580 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EHW99_RS15585 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EHW99_RS15600 ENOG4105D1S lipid A biosynthesis EHW99_RS15610 ENOG4105EZ7 amino acid ABC transporter EHW99_RS15615 ENOG4105DRP amino acid AbC transporter EHW99_RS15620 ENOG4105CDA abc transporter atp-binding protein EHW99_RS15655 ENOG4108Z0R Transferase EHW99_RS15665 ENOG4105E2X shikimate dehydrogenase EHW99_RS15675 ENOG4108WI1 Dna topoisomerase EHW99_RS15680 ENOG4108RPN Protein smg homolog EHW99_RS15685 ENOG4105C79 DNA protecting protein DprA EHW99_RS15690 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EHW99_RS15695 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EHW99_RS15700 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EHW99_RS15705 ENOG4105C1A potassium transporter peripheral membrane EHW99_RS15710 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EHW99_RS15720 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system EHW99_RS15725 ENOG4105W1Y Transcriptional regulator EHW99_RS15730 ENOG4105VTS DnaJ-like, subfamily C EHW99_RS15735 ENOG4108ZT0 50S ribosomal protein l17 EHW99_RS15740 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EHW99_RS15745 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EHW99_RS15750 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EHW99_RS15755 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EHW99_RS15760 ENOG41067V7 50S ribosomal protein L36 EHW99_RS15765 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EHW99_RS15770 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EHW99_RS15775 ENOG4105VPB 50S ribosomal protein L30 EHW99_RS15785 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EHW99_RS15790 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EHW99_RS15795 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EHW99_RS15800 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EHW99_RS15805 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EHW99_RS15810 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EHW99_RS15815 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EHW99_RS15820 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EHW99_RS15830 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EHW99_RS15835 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EHW99_RS15840 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EHW99_RS15845 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EHW99_RS15850 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EHW99_RS15855 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EHW99_RS15860 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EHW99_RS15865 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EHW99_RS15875 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) EHW99_RS15880 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EHW99_RS15885 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EHW99_RS15890 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EHW99_RS15895 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) EHW99_RS15900 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) EHW99_RS15905 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) EHW99_RS15910 ENOG4105WWK YheO domain protein EHW99_RS15915 ENOG4108V1T peptidylprolyl cis-trans isomerase EHW99_RS15920 ENOG4105VRX Protein slyX homolog EHW99_RS15925 ENOG4108YZY peptidylprolyl cis-trans isomerase EHW99_RS15930 ENOG4105VKU nucleicacid-binding protein EHW99_RS15935 ENOG4105CKD glutathione-regulated potassium-efflux system protein EHW99_RS15940 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EHW99_RS15945 ENOG4105C5H ABC transporter EHW99_RS15955 ENOG4105E2B Taurine dioxygenase EHW99_RS15960 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EHW99_RS15970 ENOG4106FTQ Taurine ABC transporter, periplasmic EHW99_RS15980 ENOG4105DNZ Alpha Beta Hydrolase EHW99_RS15985 ENOG4105YP7 UPF0270 protein EHW99_RS15990 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) EHW99_RS15995 ENOG4108UKZ OsmC family EHW99_RS16000 ENOG4107RYR Transcriptional regulator, Crp Fnr family EHW99_RS16005 ENOG410613R integral membrane protein, YccS YhfK family EHW99_RS16010 ENOG4105C8Y Acetylornithine aminotransferase EHW99_RS16020 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EHW99_RS16025 ENOG4106DTQ Protein TsgA homolog EHW99_RS16030 ENOG4105DZC cytosine deaminase EHW99_RS16035 ENOG4105DZC cytosine deaminase EHW99_RS16050 ENOG4105C31 Tryptophanyl-tRNA synthetase EHW99_RS16060 ENOG4105DJV ribulose-phosphate 3-epimerase EHW99_RS16070 ENOG4105EGB membrane protein DamX EHW99_RS16075 ENOG4105D49 3-dehydroquinate synthase EHW99_RS16080 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EHW99_RS16085 ENOG4105E4G Type IV pilus EHW99_RS16110 ENOG4108JQC penicillin-binding protein 1A EHW99_RS16115 ENOG4107RK2 ADP-ribose diphosphatase NudE EHW99_RS16120 ENOG4105DQY intracellular growth attenuator EHW99_RS16125 ENOG4105VEJ Heat shock protein EHW99_RS16130 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EHW99_RS16135 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase EHW99_RS16140 ENOG4105E0F Histidine kinase EHW99_RS16150 ENOG4108RRZ Transcription elongation factor GreB EHW99_RS16155 ENOG4105BZM domain protein EHW99_RS16160 ENOG4107QW3 Sucrose phosphorylase EHW99_RS16170 ENOG4105MJ2 Competence protein EHW99_RS16175 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) EHW99_RS16180 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) EHW99_RS16185 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EHW99_RS16190 ENOG4105E98 transcriptional regulator DeoR family EHW99_RS16195 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) EHW99_RS16200 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) EHW99_RS16205 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EHW99_RS16220 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EHW99_RS16225 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) EHW99_RS16235 ENOG4108IUM Glycogen debranching enzyme EHW99_RS16245 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EHW99_RS16250 ENOG4105C6Z Gluconate EHW99_RS16255 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EHW99_RS16260 ENOG4105DIQ Transcriptional regulator EHW99_RS16265 ENOG4105C2I pirin domain protein EHW99_RS16270 ENOG4105WCN acetyltransferase EHW99_RS16275 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EHW99_RS16285 ENOG4107T6V glycerophosphoryl diester phosphodiesterase EHW99_RS16295 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component EHW99_RS16305 ENOG4105BZ7 extracellular solute-binding protein family 1 EHW99_RS16310 ENOG4108IV0 ABC, transporter EHW99_RS16315 ENOG4105C0Z ABC transporter EHW99_RS16320 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EHW99_RS16325 ENOG4105C32 Amino acid ABC transporter (Permease) EHW99_RS16330 ENOG4105CP9 extracellular ligand-binding receptor EHW99_RS16335 ENOG4105U59 -acetyltransferase EHW99_RS16345 ENOG4105CRP Part of the ABC transporter FtsEX involved in EHW99_RS16350 ENOG4105CAK Cell division ATP-binding protein ftsE EHW99_RS16355 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EHW99_RS16360 ENOG4106H78 methyltransferase EHW99_RS16365 ENOG4105MG3 Membrane EHW99_RS16370 ENOG4107FS9 Membrane EHW99_RS16380 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) EHW99_RS16385 ENOG4105EX9 Membrane EHW99_RS16390 ENOG4108W1V Lipoprotein EHW99_RS16395 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) EHW99_RS16400 ENOG4107RJ5 oxidoreductase EHW99_RS16405 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) EHW99_RS16410 ENOG4105D7K pfkb domain protein EHW99_RS16420 ENOG4105DH8 myo-inositol catabolism EHW99_RS16425 ENOG4105C26 Dehydrogenase EHW99_RS16430 ENOG4105DSF transport protein EHW99_RS16435 ENOG4107XTP (EAL) domain protein EHW99_RS16440 ENOG4105CSH Transporter EHW99_RS16445 ENOG4105DQ4 alcohol dehydrogenase EHW99_RS16480 ENOG4105CBX hi0933 family EHW99_RS16485 ENOG4105CJ3 phosphate transporter EHW99_RS16490 ENOG4108V6B universal stress protein B EHW99_RS16500 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) EHW99_RS16505 ENOG4105DGW oligopeptidase A EHW99_RS16525 ENOG4105D6S protein involved in catabolism of external DNA EHW99_RS16530 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EHW99_RS16535 ENOG4105DC8 reductase EHW99_RS16545 ENOG4105CPW cytochrome b561 EHW99_RS16570 ENOG4108TEB UPF0114 protein EHW99_RS16595 ENOG4105UEI Transcriptional Regulator AraC Family EHW99_RS16615 ENOG4105BZ1 (ABC) transporter EHW99_RS16620 ENOG4105C8Q Methyl-accepting chemotaxis EHW99_RS16635 ENOG4105C08 Histidine kinase EHW99_RS16640 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) EHW99_RS16645 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EHW99_RS16650 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) EHW99_RS16675 ENOG4105DFG type I secretion outer membrane protein EHW99_RS16680 ENOG4107QZV Type I secretion membrane fusion protein EHW99_RS16685 ENOG4108JJ6 Type I secretion system ATPase EHW99_RS16700 ENOG4105CIB oxidoreductase Domain protein EHW99_RS16715 ENOG4105CIB oxidoreductase Domain protein EHW99_RS16720 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) EHW99_RS16730 ENOG4105WQ6 Membrane EHW99_RS16735 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EHW99_RS16745 ENOG4105CSH Transporter EHW99_RS16750 ENOG41066T0 asmA family EHW99_RS16755 ENOG4105CMB EAL domain-containing protein EHW99_RS16765 ENOG4105CS0 peptidase EHW99_RS16770 ENOG4105CK2 sodium dicarboxylate symporter EHW99_RS16775 ENOG4105BZU Histidine kinase EHW99_RS16780 ENOG4105U74 cellulose biosynthesis protein BcsE EHW99_RS16785 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) EHW99_RS16795 ENOG4105EJG cellulose synthase EHW99_RS16800 ENOG4107EEX Cellulose synthase regulator protein EHW99_RS16805 ENOG4107QZ7 Cellulose synthase catalytic subunit EHW99_RS16810 ENOG4107U53 septum site-determining protein minD EHW99_RS16820 ENOG4108JQ7 (ABC) transporter EHW99_RS16825 ENOG4105C3U ABC transporter EHW99_RS16830 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EHW99_RS16835 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EHW99_RS16840 ENOG4105DEF Extracellular solute-binding protein, family 5 EHW99_RS16850 ENOG4105DIJ Phosphoethanolamine transferase EHW99_RS16855 ENOG4108ZHJ Organic hydroperoxide resistance protein EHW99_RS16860 ENOG4105K56 Transcriptional regulator EHW99_RS16900 ENOG4105DEI Mannitol dehydrogenase EHW99_RS16910 ENOG4105MEV Acyl-transferase EHW99_RS16915 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit EHW99_RS16920 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EHW99_RS16925 ENOG4105DQ4 alcohol dehydrogenase EHW99_RS16930 ENOG4105MVF Transcriptional regulator EHW99_RS16935 ENOG4106JH6 (LipO)protein EHW99_RS16940 ENOG4105CTS PTS system mannitol-specific EHW99_RS16945 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase EHW99_RS16950 ENOG4105E61 Mannitol repressor protein EHW99_RS16955 ENOG4108YYI Protein of unknown function (DUF2810) EHW99_RS16960 ENOG4108Q9V regulatoR EHW99_RS16970 ENOG4108KXV response regulator EHW99_RS16980 ENOG4105CNN ABC, transporter EHW99_RS16985 ENOG4105C2J ABC transporter EHW99_RS16990 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EHW99_RS17000 ENOG4105E98 transcriptional regulator DeoR family EHW99_RS17010 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) EHW99_RS17015 ENOG4108U78 Glutathione S-transferase EHW99_RS17020 ENOG4108R3E Dna-3-methyladenine glycosylase i EHW99_RS17025 ENOG4108ZG0 Ompa motb domain protein EHW99_RS17030 ENOG4108M60 Transcriptional regulator EHW99_RS17050 ENOG4105D7K pfkb domain protein EHW99_RS17055 ENOG4108I5G Major Facilitator superfamily EHW99_RS17060 ENOG4105C5I Dehydrogenase EHW99_RS17075 ENOG4105JKW Valine--pyruvate aminotransferase EHW99_RS17080 ENOG4108ZNX Heat shock protein EHW99_RS17085 ENOG4105R2A (LipO)protein EHW99_RS17090 ENOG4105D99 atp gtp-binding protein EHW99_RS17095 ENOG410667J hydrolase EHW99_RS17100 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EHW99_RS17105 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EHW99_RS17110 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EHW99_RS17115 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EHW99_RS17120 ENOG4105VG0 50S ribosomal protein l34 EHW99_RS17125 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EHW99_RS17135 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EHW99_RS17140 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EHW99_RS17145 ENOG4105E8Q phosphopantetheinyl transferase EHW99_RS17150 ENOG4105C7N Xanthine uracil vitamin C permease EHW99_RS17160 ENOG4107RGD Major Facilitator superfamily EHW99_RS17170 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EHW99_RS17175 ENOG4105E2Z phosphate ABC transporter (Permease EHW99_RS17180 ENOG4105C8U phosphate abc transporter EHW99_RS17185 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) EHW99_RS17190 ENOG4105ZTC transcriptional activator, Ogr delta EHW99_RS17195 ENOG4105EDQ levansucrase EC 2.4.1.10 EHW99_RS17205 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EHW99_RS17210 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EHW99_RS17215 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EHW99_RS17220 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EHW99_RS17225 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EHW99_RS17230 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EHW99_RS17235 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EHW99_RS17240 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EHW99_RS17245 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EHW99_RS17250 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) EHW99_RS17255 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation EHW99_RS17260 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EHW99_RS17285 ENOG4105EGI Transcriptional regulator EHW99_RS17290 ENOG4105C26 Dehydrogenase EHW99_RS17295 ENOG4105C8Q Methyl-accepting chemotaxis EHW99_RS17300 ENOG4105VYA Uncharacterized conserved protein (DUF2132) EHW99_RS17365 ENOG4107QJE Chromosome Partitioning Protein EHW99_RS17375 ENOG4108WF3 methyltransferase EHW99_RS17380 ENOG4105C94 Transporter EHW99_RS17400 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)