locus-tag	class	description
EHW99_RS00005	COG0716	FMN binding
EHW99_RS00010	COG1522	sequence-specific DNA binding
EHW99_RS00020	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EHW99_RS00030	COG3158	transport of potassium into the cell
EHW99_RS00050	COG3111	PFAM Bacterial OB fold (BOF) protein
EHW99_RS00075	COG1129	ABC transporter
EHW99_RS00080	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW99_RS00085	COG1879	ABC-type sugar transport system periplasmic component
EHW99_RS00090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW99_RS00095	COG1609	Transcriptional regulator
EHW99_RS00100	COG0477	Major facilitator Superfamily
EHW99_RS00130	COG0746	molybdenum cofactor guanylyltransferase activity
EHW99_RS00135	COG3084	Protein conserved in bacteria
EHW99_RS00150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHW99_RS00150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHW99_RS00160	COG3078	GTPase activator activity
EHW99_RS00175	COG3852	Histidine kinase
EHW99_RS00190	COG1011	Hydrolase
EHW99_RS00200	COG1490	D-aminoacyl-tRNA deacylase activity
EHW99_RS00205	COG0456	acetyltransferase
EHW99_RS00210	COG1187	pseudouridine synthase activity
EHW99_RS00215	COG2982	Protein involved in outer membrane biogenesis
EHW99_RS00220	COG2233	PERMEase
EHW99_RS00225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EHW99_RS00230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHW99_RS00235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHW99_RS00240	COG1758	RNA polymerase activity
EHW99_RS00245	COG0194	GDP metabolic process
EHW99_RS00255	COG2860	membrane
EHW99_RS00260	COG2197	response regulator
EHW99_RS00270	COG2824	Alkylphosphonate utilization operon protein PhnA
EHW99_RS00325	COG1401	restriction endodeoxyribonuclease activity
EHW99_RS00340	COG1561	YicC-like family, N-terminal region
EHW99_RS00350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EHW99_RS00355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EHW99_RS00360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EHW99_RS00365	COG1309	transcriptional regulator
EHW99_RS00370	COG0756	dUTP diphosphatase activity
EHW99_RS00375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EHW99_RS00380	COG2003	Belongs to the UPF0758 family
EHW99_RS00385	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EHW99_RS00395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EHW99_RS00400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EHW99_RS00410	COG1519	Transferase
EHW99_RS00415	COG0859	PFAM glycosyl transferase family 9
EHW99_RS00420	COG0438	transferase activity, transferring glycosyl groups
EHW99_RS00430	COG0859	PFAM glycosyl transferase family 9
EHW99_RS00445	COG1215	transferase activity, transferring glycosyl groups
EHW99_RS00450	COG3307	-O-antigen
EHW99_RS00455	COG0438	transferase activity, transferring glycosyl groups
EHW99_RS00460	COG0859	PFAM glycosyl transferase family 9
EHW99_RS00465	COG0859	PFAM glycosyl transferase family 9
EHW99_RS00470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW99_RS00475	COG2861	carbohydrate metabolic process
EHW99_RS00480	COG4942	peptidase
EHW99_RS00485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHW99_RS00490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHW99_RS00495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EHW99_RS00500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EHW99_RS00510	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EHW99_RS00515	COG2205	protein histidine kinase activity
EHW99_RS00520	COG0745	RESPONSE REGULATOR receiver
EHW99_RS00525	COG3678	ATP-independent chaperone mediated protein folding
EHW99_RS00535	COG0205	6-phosphofructokinase activity
EHW99_RS00540	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EHW99_RS00550	COG1295	ribonuclease BN
EHW99_RS00575	COG0149	triose-phosphate isomerase activity
EHW99_RS00585	COG3152	Membrane
EHW99_RS00600	COG2814	Major facilitator Superfamily
EHW99_RS00605	COG1494	fructose-1,6-bisphosphatase
EHW99_RS00620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EHW99_RS00625	COG3074	FtsZ-dependent cytokinesis
EHW99_RS00630	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHW99_RS00635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EHW99_RS00640	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EHW99_RS00645	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EHW99_RS00650	COG1609	Transcriptional regulator
EHW99_RS00655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EHW99_RS00660	COG0254	rRNA binding
EHW99_RS00665	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EHW99_RS00670	COG0626	cystathionine gamma-synthase activity
EHW99_RS00675	COG0527	aspartate kinase activity
EHW99_RS00675	COG0460	homoserine dehydrogenase
EHW99_RS00685	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EHW99_RS00690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHW99_RS00700	COG0137	argininosuccinate synthase activity
EHW99_RS00705	COG0165	Argininosuccinate lyase
EHW99_RS00710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHW99_RS00710	COG0678	peroxiredoxin activity
EHW99_RS00720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHW99_RS00725	COG1309	transcriptional regulator
EHW99_RS00735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHW99_RS00740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EHW99_RS00775	COG0583	DNA-binding transcription factor activity
EHW99_RS00780	COG3085	chromosome segregation
EHW99_RS00785	COG0606	chelatase, subunit chli
EHW99_RS00800	COG3978	acetolactate synthase activity
EHW99_RS00810	COG0129	dihydroxy-acid dehydratase activity
EHW99_RS00815	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EHW99_RS00825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EHW99_RS00840	COG0248	Ppx GppA phosphatase
EHW99_RS00845	COG0513	Belongs to the DEAD box helicase family
EHW99_RS00850	COG3118	belongs to the thioredoxin family
EHW99_RS00855	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EHW99_RS00860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EHW99_RS00870	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EHW99_RS00875	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EHW99_RS00880	COG1088	dTDP-glucose 4,6-dehydratase activity
EHW99_RS00885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EHW99_RS00890	COG0456	acetyltransferase
EHW99_RS00895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHW99_RS00900	COG2244	polysaccharide biosynthetic process
EHW99_RS00905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EHW99_RS00915	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EHW99_RS00955	COG3071	HemY protein
EHW99_RS00960	COG2959	enzyme of heme biosynthesis
EHW99_RS00965	COG1587	Uroporphyrinogen-III synthase
EHW99_RS00970	COG0181	hydroxymethylbilane synthase activity
EHW99_RS00975	COG3072	Adenylate cyclase
EHW99_RS00985	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EHW99_RS00990	COG3159	Protein conserved in bacteria
EHW99_RS01000	COG1011	Hydrolase
EHW99_RS01005	COG0210	DNA helicase
EHW99_RS01010	COG0598	Magnesium transport protein CorA
EHW99_RS01015	COG2050	protein possibly involved in aromatic compounds catabolism
EHW99_RS01020	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
EHW99_RS01025	COG0514	ATP-dependent DNA helicase (RecQ)
EHW99_RS01030	COG1280	lysine exporter protein (LysE YggA)
EHW99_RS01035	COG2267	carboxylic ester hydrolase activity
EHW99_RS01040	COG0561	phosphatase activity
EHW99_RS01045	COG2271	Major facilitator Superfamily
EHW99_RS01050	COG4807	Protein conserved in bacteria
EHW99_RS01055	COG0583	DNA-binding transcription factor activity
EHW99_RS01060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHW99_RS01065	COG0412	Dienelactone hydrolase
EHW99_RS01075	COG1322	Protein conserved in bacteria
EHW99_RS01080	COG2226	methyltransferase
EHW99_RS01090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EHW99_RS01100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHW99_RS01105	COG0805	protein transport
EHW99_RS01120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EHW99_RS01130	COG0183	Belongs to the thiolase family
EHW99_RS01140	COG0006	proline dipeptidase activity
EHW99_RS01145	COG1739	Uncharacterized protein family UPF0029
EHW99_RS01150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EHW99_RS01155	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EHW99_RS01185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EHW99_RS01185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EHW99_RS01190	COG1072	(Pantothenic acid kinase))
EHW99_RS01225	COG0250	Participates in transcription elongation, termination and antitermination
EHW99_RS01230	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EHW99_RS01235	COG0081	regulation of translation
EHW99_RS01240	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EHW99_RS01245	COG0222	ribosome binding
EHW99_RS01250	COG0085	RNA polymerase activity
EHW99_RS01255	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EHW99_RS01300	COG4571	Outer membrane protease
EHW99_RS01310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EHW99_RS01315	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EHW99_RS01320	COG2816	NAD+ diphosphatase activity
EHW99_RS01325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EHW99_RS01330	COG1515	deoxyribonuclease V activity
EHW99_RS01350	COG0151	Belongs to the GarS family
EHW99_RS01355	COG0138	bifunctional purine biosynthesis protein purh
EHW99_RS01380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EHW99_RS01385	COG1283	sodium-dependent phosphate transmembrane transporter activity
EHW99_RS01390	COG0527	aspartate kinase activity
EHW99_RS01395	COG0166	Belongs to the GPI family
EHW99_RS01415	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW99_RS01420	COG3223	Belongs to the PsiE family
EHW99_RS01425	COG3161	chorismate lyase activity
EHW99_RS01440	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EHW99_RS01445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EHW99_RS01450	COG0534	Mate efflux family protein
EHW99_RS01455	COG3237	CsbD-like
EHW99_RS01460	COG0735	belongs to the Fur family
EHW99_RS01480	COG1403	HNH endonuclease
EHW99_RS01545	COG2246	polysaccharide biosynthetic process
EHW99_RS01560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHW99_RS01585	COG1448	Aminotransferase
EHW99_RS01595	COG2315	Protein conserved in bacteria
EHW99_RS01600	COG1388	LysM domain
EHW99_RS01600	COG1470	cell adhesion involved in biofilm formation
EHW99_RS01605	COG1064	alcohol dehydrogenase
EHW99_RS01610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EHW99_RS01615	COG0629	single-stranded DNA binding
EHW99_RS01620	COG2831	hemolysin activation secretion protein
EHW99_RS01650	COG0625	glutathione transferase activity
EHW99_RS01655	COG2252	PERMEase
EHW99_RS01660	COG0025	NhaP-type Na H and K H
EHW99_RS01665	COG0583	DNA-binding transcription factor activity
EHW99_RS01670	COG1380	Effector of murein hydrolase LrgA
EHW99_RS01675	COG1346	cytolysis
EHW99_RS01685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHW99_RS01690	COG3162	membrane
EHW99_RS01700	COG1301	dicarboxylic acid transport
EHW99_RS01705	COG0840	transmembrane signaling receptor activity
EHW99_RS01725	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EHW99_RS01730	COG3300	MHYT domain
EHW99_RS01730	COG5001	Diguanylate cyclase
EHW99_RS01750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EHW99_RS01765	COG0583	DNA-binding transcription factor activity
EHW99_RS01780	COG0583	DNA-binding transcription factor activity
EHW99_RS01785	COG1280	lysine exporter protein (LysE YggA)
EHW99_RS01795	COG2382	esterase
EHW99_RS01800	COG5383	Protein conserved in bacteria
EHW99_RS01805	COG0561	phosphatase activity
EHW99_RS01815	COG1902	pentaerythritol trinitrate reductase activity
EHW99_RS01825	COG1028	Short-chain dehydrogenase reductase Sdr
EHW99_RS01835	COG4774	siderophore transport
EHW99_RS01845	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EHW99_RS01850	COG0076	glutamate decarboxylase activity
EHW99_RS02025	COG1181	Belongs to the D-alanine--D-alanine ligase family
EHW99_RS02035	COG2890	protein-(glutamine-N5) methyltransferase activity
EHW99_RS02050	COG0124	histidyl-tRNA synthetase
EHW99_RS02065	COG0367	asparagine synthase
EHW99_RS02075	COG2211	Major facilitator Superfamily
EHW99_RS02090	COG1309	transcriptional regulator
EHW99_RS02100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EHW99_RS02105	COG1027	Aspartate ammonia-lyase
EHW99_RS02110	COG3030	protein affecting phage T7 exclusion by the F plasmid
EHW99_RS02115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EHW99_RS02120	COG0459	protein refolding
EHW99_RS02130	COG1509	lysine 2,3-aminomutase activity
EHW99_RS02135	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHW99_RS02150	COG3040	lipid binding
EHW99_RS02155	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EHW99_RS02160	COG1511	domain protein
EHW99_RS02160	COG3264	Mechanosensitive ion channel
EHW99_RS02165	COG0688	phosphatidylethanolamine metabolic process
EHW99_RS02170	COG1162	GTPase activity
EHW99_RS02175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EHW99_RS02200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EHW99_RS02200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EHW99_RS02205	COG0802	atpase or kinase
EHW99_RS02210	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHW99_RS02215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EHW99_RS02220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EHW99_RS02230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EHW99_RS02235	COG0330	HflC and HflK could
EHW99_RS02240	COG0330	HflC and HflK could
EHW99_RS02245	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EHW99_RS02250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EHW99_RS02255	COG0557	exoribonuclease II activity
EHW99_RS02260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHW99_RS02270	COG0840	transmembrane signaling receptor activity
EHW99_RS02275	COG1073	alpha beta
EHW99_RS02280	COG0360	Binds together with S18 to 16S ribosomal RNA
EHW99_RS02285	COG2965	DNA replication, synthesis of RNA primer
EHW99_RS02290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EHW99_RS02295	COG0359	binds to the 23S rRNA
EHW99_RS02300	COG3061	Opacity-associated protein A
EHW99_RS02305	COG0545	Peptidyl-prolyl cis-trans isomerase
EHW99_RS02315	COG1218	3'(2'),5'-bisphosphate nucleotidase
EHW99_RS02325	COG1253	flavin adenine dinucleotide binding
EHW99_RS02330	COG0729	surface antigen
EHW99_RS02340	COG2105	PFAM AIG2 family protein
EHW99_RS02350	COG0840	transmembrane signaling receptor activity
EHW99_RS02355	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EHW99_RS02360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EHW99_RS02365	COG3028	Belongs to the UPF0307 family
EHW99_RS02370	COG0312	modulator of DNA gyrase
EHW99_RS02405	COG3964	amidohydrolase
EHW99_RS02420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW99_RS02420	COG3711	transcriptional antiterminator
EHW99_RS02425	COG2823	Periplasmic or secreted lipoprotein
EHW99_RS02430	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EHW99_RS02435	COG0792	nuclease activity
EHW99_RS02440	COG3107	peptidoglycan biosynthetic process
EHW99_RS02445	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EHW99_RS02470	COG1741	Belongs to the pirin family
EHW99_RS02475	COG0583	DNA-binding transcription factor activity
EHW99_RS02485	COG2259	Doxx family
EHW99_RS02495	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
EHW99_RS02500	COG4575	ribosome binding
EHW99_RS02505	COG1422	Protein of unknown function (DUF1090)
EHW99_RS02515	COG0586	Pfam SNARE associated Golgi protein
EHW99_RS02525	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EHW99_RS02530	COG0861	Integral membrane protein TerC family
EHW99_RS02535	COG0038	chloride channel
EHW99_RS02540	COG1063	alcohol dehydrogenase
EHW99_RS02545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHW99_RS02550	COG2223	nitrite transmembrane transporter activity
EHW99_RS02555	COG1451	nucleotide metabolic process
EHW99_RS02560	COG2813	Specifically methylates the guanine in position
EHW99_RS02565	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHW99_RS02565	COG1902	pentaerythritol trinitrate reductase activity
EHW99_RS02575	COG0288	reversible hydration of carbon dioxide
EHW99_RS02580	COG0659	secondary active sulfate transmembrane transporter activity
EHW99_RS02595	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EHW99_RS02600	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EHW99_RS02610	COG0535	radical SAM domain protein
EHW99_RS02635	COG3731	PTS system glucitol sorbitol-specific IIA component
EHW99_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
EHW99_RS02645	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW99_RS02650	COG1349	DNA-binding transcription factor activity
EHW99_RS02655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EHW99_RS02655	COG0517	IMP dehydrogenase activity
EHW99_RS02745	COG0477	Major facilitator Superfamily
EHW99_RS02750	COG1609	Transcriptional regulator
EHW99_RS02775	COG3706	GGDEF domain
EHW99_RS02800	COG2813	Specifically methylates the guanine in position
EHW99_RS02805	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
EHW99_RS02810	COG0456	acetyltransferase
EHW99_RS02815	COG1011	Hydrolase
EHW99_RS02935	COG3501	Rhs element vgr protein
EHW99_RS02955	COG3501	Rhs element vgr protein
EHW99_RS02965	COG3209	COG3209 Rhs family protein
EHW99_RS03000	COG1397	ADP-ribosylglycohydrolase
EHW99_RS03005	COG2818	Glycosylase
EHW99_RS03010	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EHW99_RS03010	COG2755	lipolytic protein G-D-S-L family
EHW99_RS03015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EHW99_RS03020	COG2823	Periplasmic or secreted lipoprotein
EHW99_RS03025	COG5487	UPF0391 membrane protein
EHW99_RS03030	COG4667	esterase of the alpha-beta hydrolase superfamily
EHW99_RS03035	COG0084	hydrolase, TatD family'
EHW99_RS03040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EHW99_RS03045	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EHW99_RS03050	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EHW99_RS03055	COG0813	purine-nucleoside phosphorylase activity
EHW99_RS03060	COG3550	peptidyl-serine autophosphorylation
EHW99_RS03065	COG3726	membrane protein affecting hemolysin expression
EHW99_RS03070	COG0560	Phosphoserine phosphatase
EHW99_RS03095	COG0604	alcohol dehydrogenase
EHW99_RS03100	COG0583	DNA-binding transcription factor activity
EHW99_RS03105	COG0488	(ABC) transporter
EHW99_RS03115	COG1349	DNA-binding transcription factor activity
EHW99_RS03125	COG0741	lytic transglycosylase activity
EHW99_RS03130	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EHW99_RS03135	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EHW99_RS03140	COG0406	alpha-ribazole phosphatase activity
EHW99_RS03150	COG3708	Transcriptional regulator
EHW99_RS03150	COG2207	Transcriptional regulator
EHW99_RS03155	COG3045	CreA protein
EHW99_RS03160	COG0745	RESPONSE REGULATOR receiver
EHW99_RS03175	COG0083	homoserine kinase activity
EHW99_RS03185	COG3022	response to hydroperoxide
EHW99_RS03195	COG0521	Mo-molybdopterin cofactor biosynthetic process
EHW99_RS03205	COG0443	Heat shock 70 kDa protein
EHW99_RS03210	COG0484	heat shock protein binding
EHW99_RS03215	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHW99_RS03220	COG0268	Binds directly to 16S ribosomal RNA
EHW99_RS03225	COG0196	riboflavin kinase activity
EHW99_RS03230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EHW99_RS03235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EHW99_RS03240	COG1047	Peptidyl-prolyl cis-trans
EHW99_RS03245	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EHW99_RS03250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EHW99_RS03255	COG0505	Belongs to the CarA family
EHW99_RS03265	COG1280	lysine exporter protein (LysE YggA)
EHW99_RS03270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EHW99_RS03275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EHW99_RS03280	COG2967	ApaG domain
EHW99_RS03285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EHW99_RS03290	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EHW99_RS03305	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EHW99_RS03310	COG0564	pseudouridine synthase activity
EHW99_RS03315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHW99_RS03320	COG0417	DNA replication proofreading
EHW99_RS03325	COG0586	Pfam SNARE associated Golgi protein
EHW99_RS03330	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EHW99_RS03335	COG1178	ABC-type Fe3 transport system permease component
EHW99_RS03340	COG4143	(ABC) transporter
EHW99_RS03345	COG4533	DNA binding
EHW99_RS03350	COG2814	Major facilitator Superfamily
EHW99_RS03355	COG0066	3-isopropylmalate dehydratase activity
EHW99_RS03365	COG0473	3-isopropylmalate dehydrogenase activity
EHW99_RS03370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHW99_RS03380	COG0028	Belongs to the TPP enzyme family
EHW99_RS03395	COG2001	Belongs to the MraZ family
EHW99_RS03400	COG0275	rRNA processing
EHW99_RS03405	COG3116	cell division
EHW99_RS03410	COG0768	penicillin binding
EHW99_RS03415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EHW99_RS03420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EHW99_RS03425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EHW99_RS03435	COG0772	Belongs to the SEDS family
EHW99_RS03440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EHW99_RS03450	COG1181	Belongs to the D-alanine--D-alanine ligase family
EHW99_RS03460	COG0849	cell division
EHW99_RS03465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EHW99_RS03470	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EHW99_RS03485	COG0653	protein targeting
EHW99_RS03495	COG3397	chitin binding
EHW99_RS03570	COG0494	nUDIX hydrolase
EHW99_RS03575	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EHW99_RS03580	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EHW99_RS03590	COG0516	GMP reductase activity
EHW99_RS03595	COG1459	type II secretion system
EHW99_RS03600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EHW99_RS03605	COG4969	Belongs to the N-Me-Phe pilin family
EHW99_RS03620	COG3725	Membrane protein required for beta-lactamase induction
EHW99_RS03645	COG3940	Belongs to the glycosyl hydrolase 43 family
EHW99_RS03650	COG2211	Major facilitator Superfamily
EHW99_RS03655	COG1113	amino acid transport
EHW99_RS03660	COG2186	Transcriptional regulator
EHW99_RS03665	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EHW99_RS03670	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW99_RS03675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHW99_RS03680	COG1028	Short-chain dehydrogenase reductase Sdr
EHW99_RS03685	COG1122	ATPase activity
EHW99_RS03690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EHW99_RS03695	COG1268	BioY protein
EHW99_RS03710	COG0318	PFAM AMP-dependent synthetase and ligase
EHW99_RS03715	COG0183	Belongs to the thiolase family
EHW99_RS03720	COG1024	Enoyl-CoA hydratase
EHW99_RS03725	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EHW99_RS03735	COG2175	clavaminate synthase activity
EHW99_RS03740	COG1203	CRISPR-associated helicase, Cas3
EHW99_RS03755	COG1857	crispr-associated protein
EHW99_RS03770	COG1518	maintenance of DNA repeat elements
EHW99_RS03775	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHW99_RS03795	COG3112	Uncharacterised protein family (UPF0231)
EHW99_RS03800	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EHW99_RS03805	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EHW99_RS03835	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EHW99_RS03840	COG0288	reversible hydration of carbon dioxide
EHW99_RS03845	COG1131	(ABC) transporter
EHW99_RS03850	COG0842	Transport permease protein
EHW99_RS03855	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EHW99_RS03860	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EHW99_RS03865	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EHW99_RS03870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EHW99_RS03890	COG1489	DNA binding
EHW99_RS03895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EHW99_RS03900	COG1643	Atp-dependent helicase
EHW99_RS03905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHW99_RS03915	COG4104	PAAR repeat-containing protein
EHW99_RS03915	COG3209	COG3209 Rhs family protein
EHW99_RS03930	COG3077	Addiction module antitoxin, RelB DinJ family
EHW99_RS03935	COG2026	Addiction module toxin, RelE StbE family
EHW99_RS03950	COG1120	ATPase activity
EHW99_RS03955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHW99_RS03965	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EHW99_RS03970	COG0316	Belongs to the HesB IscA family
EHW99_RS03980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHW99_RS03990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHW99_RS04000	COG2171	N-acyltransferase activity
EHW99_RS04005	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EHW99_RS04015	COG0052	Belongs to the universal ribosomal protein uS2 family
EHW99_RS04020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EHW99_RS04025	COG0528	UMP kinase activity
EHW99_RS04030	COG0233	cytoplasmic translational termination
EHW99_RS04035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EHW99_RS04040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EHW99_RS04045	COG0575	Belongs to the CDS family
EHW99_RS04050	COG0750	zinc metalloprotease
EHW99_RS04055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW99_RS04060	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EHW99_RS04065	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHW99_RS04070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHW99_RS04075	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHW99_RS04080	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EHW99_RS04085	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EHW99_RS04095	COG0825	malonyl-CoA metabolic process
EHW99_RS04105	COG0346	lactoylglutathione lyase activity
EHW99_RS04110	COG0037	tRNA processing
EHW99_RS04120	COG4568	rho-dependent transcription termination
EHW99_RS04145	COG0442	prolyl-tRNA aminoacylation
EHW99_RS04150	COG1720	tRNA m6t6A37 methyltransferase activity
EHW99_RS04160	COG1464	Belongs to the NlpA lipoprotein family
EHW99_RS04165	COG2011	ABC-type metal ion transport system permease component
EHW99_RS04170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EHW99_RS04175	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EHW99_RS04205	COG0477	Major facilitator Superfamily
EHW99_RS04210	COG5544	Lipoprotein
EHW99_RS04215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHW99_RS04220	COG1042	CoA-binding domain protein
EHW99_RS04220	COG0045	succinate-CoA ligase (ADP-forming) activity
EHW99_RS04220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW99_RS04230	COG3118	belongs to the thioredoxin family
EHW99_RS04235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHW99_RS04240	COG2814	Major facilitator Superfamily
EHW99_RS04245	COG1566	PFAM secretion protein HlyD family protein
EHW99_RS04250	COG1846	Transcriptional regulator
EHW99_RS04255	COG2814	Major facilitator Superfamily
EHW99_RS04260	COG2113	Glycine betaine
EHW99_RS04265	COG4176	ABC-type proline glycine betaine transport system permease component
EHW99_RS04285	COG1780	Probably involved in ribonucleotide reductase function
EHW99_RS04290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EHW99_RS04305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW99_RS04320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EHW99_RS04335	COG0745	RESPONSE REGULATOR receiver
EHW99_RS04345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EHW99_RS04350	COG1677	Flagellar hook-basal body complex protein FliE
EHW99_RS04365	COG1317	bacterial-type flagellum organization
EHW99_RS04370	COG1157	protein secretion by the type III secretion system
EHW99_RS04385	COG1580	Controls the rotational direction of flagella during chemotaxis
EHW99_RS04395	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHW99_RS04400	COG3190	flagellar
EHW99_RS04410	COG1987	bacterial-type flagellum assembly
EHW99_RS04420	COG4797	methyltransferase
EHW99_RS04420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHW99_RS04465	COG3418	PFAM FlgN family protein
EHW99_RS04480	COG1815	bacterial-type flagellum-dependent cell motility
EHW99_RS04510	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EHW99_RS04520	COG3951	Flagellar rod assembly protein muramidase FlgJ
EHW99_RS04520	COG1705	Flagellar rod assembly protein muramidase FlgJ
EHW99_RS04530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHW99_RS04535	COG0840	transmembrane signaling receptor activity
EHW99_RS04565	COG2198	Histidine kinase
EHW99_RS04565	COG0643	Histidine kinase
EHW99_RS04570	COG0835	chemotaxis
EHW99_RS04595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EHW99_RS04600	COG2867	negative regulation of translational initiation
EHW99_RS04605	COG2914	Belongs to the UPF0125 (RnfH) family
EHW99_RS04610	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW99_RS04615	COG0497	DNA recombination
EHW99_RS04620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EHW99_RS04625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EHW99_RS04630	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EHW99_RS04635	COG0513	Belongs to the DEAD box helicase family
EHW99_RS04640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EHW99_RS04645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EHW99_RS04650	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EHW99_RS04665	COG3026	antisigma factor binding
EHW99_RS04670	COG3086	response to oxidative stress
EHW99_RS04685	COG0481	GTPase activity
EHW99_RS04695	COG0571	ribonuclease III activity
EHW99_RS04705	COG1381	Involved in DNA repair and RecF pathway recombination
EHW99_RS04710	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EHW99_RS04715	COG0736	holo-[acyl-carrier-protein] synthase activity
EHW99_RS04725	COG1737	Transcriptional regulator
EHW99_RS04730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EHW99_RS04735	COG0560	Phosphoserine phosphatase
EHW99_RS04745	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EHW99_RS04750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EHW99_RS04750	COG0047	phosphoribosylformylglycinamidine synthase activity
EHW99_RS04755	COG2205	protein histidine kinase activity
EHW99_RS04760	COG3170	Tfp pilus assembly protein FimV
EHW99_RS04765	COG2204	response regulator
EHW99_RS04770	COG0347	Belongs to the P(II) protein family
EHW99_RS04775	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EHW99_RS04780	COG3711	transcriptional antiterminator
EHW99_RS04785	COG0483	inositol monophosphate 1-phosphatase activity
EHW99_RS04795	COG1959	2 iron, 2 sulfur cluster binding
EHW99_RS04800	COG1104	cysteine desulfurase activity
EHW99_RS04805	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHW99_RS04815	COG0531	amino acid
EHW99_RS04820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHW99_RS04830	COG3938	Belongs to the proline racemase family
EHW99_RS04845	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHW99_RS04850	COG1012	belongs to the aldehyde dehydrogenase family
EHW99_RS04860	COG2897	thiosulfate sulfurtransferase activity
EHW99_RS04865	COG0105	UTP biosynthetic process
EHW99_RS04870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EHW99_RS04880	COG1426	Protein conserved in bacteria
EHW99_RS04885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EHW99_RS04890	COG0124	histidyl-tRNA synthetase
EHW99_RS04895	COG2976	Protein conserved in bacteria
EHW99_RS04900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW99_RS04905	COG1160	GTP binding
EHW99_RS04915	COG4993	Dehydrogenase
EHW99_RS04930	COG1570	exodeoxyribonuclease VII activity
EHW99_RS04935	COG0517	IMP dehydrogenase activity
EHW99_RS04935	COG0516	GMP reductase activity
EHW99_RS04970	COG3122	Protein conserved in bacteria
EHW99_RS04985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW99_RS04990	COG2271	Major facilitator Superfamily
EHW99_RS04995	COG2239	Acts as a magnesium transporter
EHW99_RS05000	COG2200	EAL domain
EHW99_RS05005	COG0500	methyltransferase
EHW99_RS05015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EHW99_RS05020	COG0573	inorganic phosphate transmembrane transporter activity
EHW99_RS05025	COG0581	inorganic phosphate transmembrane transporter activity
EHW99_RS05030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHW99_RS05035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EHW99_RS05040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EHW99_RS05050	COG2233	PERMEase
EHW99_RS05055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EHW99_RS05060	COG1393	Belongs to the ArsC family
EHW99_RS05070	COG3706	GGDEF domain
EHW99_RS05075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EHW99_RS05080	COG2716	regulation of RNA biosynthetic process
EHW99_RS05085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHW99_RS05090	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EHW99_RS05095	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EHW99_RS05100	COG2321	neutral zinc metallopeptidase
EHW99_RS05105	COG1444	tRNA N-acetyltransferase activity
EHW99_RS05120	COG3209	COG3209 Rhs family protein
EHW99_RS05120	COG4104	PAAR repeat-containing protein
EHW99_RS05140	COG3209	COG3209 Rhs family protein
EHW99_RS05140	COG4104	PAAR repeat-containing protein
EHW99_RS05165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHW99_RS05170	COG1393	Belongs to the ArsC family
EHW99_RS05185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW99_RS05190	COG2197	response regulator
EHW99_RS05195	COG3850	Histidine kinase
EHW99_RS05210	COG0494	nUDIX hydrolase
EHW99_RS05215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EHW99_RS05220	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EHW99_RS05225	COG0408	coproporphyrinogen oxidase activity
EHW99_RS05230	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHW99_RS05255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EHW99_RS05260	COG4208	sulfate ABC transporter
EHW99_RS05265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EHW99_RS05275	COG0745	RESPONSE REGULATOR receiver
EHW99_RS05280	COG2205	protein histidine kinase activity
EHW99_RS05290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHW99_RS05300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EHW99_RS05305	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EHW99_RS05310	COG3115	cell septum assembly
EHW99_RS05315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EHW99_RS05320	COG3530	Putative quorum-sensing-regulated virulence factor
EHW99_RS05325	COG0385	Bile acid
EHW99_RS05330	COG0583	DNA-binding transcription factor activity
EHW99_RS05375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHW99_RS05380	COG3415	Transposase
EHW99_RS05385	COG2116	formate transmembrane transporter activity
EHW99_RS05400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EHW99_RS05405	COG1914	H( )-stimulated, divalent metal cation uptake system
EHW99_RS05415	COG0667	Aldo Keto reductase
EHW99_RS05420	COG3961	Belongs to the TPP enzyme family
EHW99_RS05425	COG0837	glucose binding
EHW99_RS05440	COG0436	Aminotransferase
EHW99_RS05480	COG0668	transmembrane transport
EHW99_RS05515	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHW99_RS05520	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHW99_RS05525	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHW99_RS05530	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EHW99_RS05535	COG1138	Cytochrome C-type biogenesis protein
EHW99_RS05545	COG4235	cytochrome complex assembly
EHW99_RS05545	COG3088	subunit of a heme lyase
EHW99_RS05550	COG3088	subunit of a heme lyase
EHW99_RS05550	COG4235	cytochrome complex assembly
EHW99_RS05560	COG2067	long-chain fatty acid transport protein
EHW99_RS05575	COG0183	Belongs to the thiolase family
EHW99_RS05580	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHW99_RS05580	COG1024	Enoyl-CoA hydratase
EHW99_RS05585	COG2062	phosphohistidine phosphatase, SixA
EHW99_RS05590	COG2840	Smr protein MutS2
EHW99_RS05600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EHW99_RS05610	COG0730	response to heat
EHW99_RS05615	COG3101	peptidyl-lysine hydroxylation
EHW99_RS05630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHW99_RS05675	COG2207	Transcriptional regulator
EHW99_RS05685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EHW99_RS05695	COG0586	Pfam SNARE associated Golgi protein
EHW99_RS05710	COG0285	dihydrofolate synthase activity
EHW99_RS05715	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EHW99_RS05720	COG1286	toxin biosynthetic process
EHW99_RS05725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EHW99_RS05730	COG0163	prenyltransferase activity
EHW99_RS05745	COG4160	amino acid transport
EHW99_RS05750	COG4598	ABC transporter
EHW99_RS05755	COG1090	epimerase
EHW99_RS05770	COG1177	transmembrane transport
EHW99_RS05775	COG1176	ABC-type spermidine putrescine transport system, permease component I
EHW99_RS05785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHW99_RS05795	COG3842	ATPase activity
EHW99_RS05800	COG0857	belongs to the CobB CobQ family
EHW99_RS05800	COG0280	phosphate acetyltransferase
EHW99_RS05805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EHW99_RS05810	COG3092	negative regulation of chromosome organization
EHW99_RS05815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHW99_RS05835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EHW99_RS05840	COG0436	Aminotransferase
EHW99_RS05845	COG0583	DNA-binding transcription factor activity
EHW99_RS05850	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW99_RS05855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW99_RS05860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW99_RS05860	COG0649	NAD binding
EHW99_RS05870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EHW99_RS05880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EHW99_RS05885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW99_RS05890	COG0839	Belongs to the complex I subunit 6 family
EHW99_RS05895	COG0713	ATP synthesis coupled electron transport
EHW99_RS05900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EHW99_RS05905	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW99_RS05910	COG1007	ATP synthesis coupled electron transport
EHW99_RS05925	COG2153	protein acetylation
EHW99_RS05930	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EHW99_RS05935	COG4575	ribosome binding
EHW99_RS05950	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EHW99_RS05970	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHW99_RS05980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHW99_RS05985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHW99_RS05995	COG2205	protein histidine kinase activity
EHW99_RS05995	COG0784	Response regulator, receiver
EHW99_RS06000	COG2197	response regulator
EHW99_RS06005	COG2198	Histidine kinase
EHW99_RS06005	COG0642	Histidine kinase
EHW99_RS06030	COG3145	DNA-N1-methyladenine dioxygenase activity
EHW99_RS06040	COG2977	Belongs to the P-Pant transferase superfamily
EHW99_RS06100	COG3083	sulfuric ester hydrolase activity
EHW99_RS06105	COG3082	Protein of unknown function (DUF1414)
EHW99_RS06110	COG3081	Nucleoid-associated protein
EHW99_RS06115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EHW99_RS06120	COG1061	Type III restriction enzyme res subunit
EHW99_RS06125	COG1187	pseudouridine synthase activity
EHW99_RS06130	COG2814	Major facilitator Superfamily
EHW99_RS06140	COG4172	Belongs to the ABC transporter superfamily
EHW99_RS06145	COG4239	(ABC) transporter, permease
EHW99_RS06150	COG4174	ABC transporter (Permease)
EHW99_RS06155	COG4166	transmembrane transport
EHW99_RS06160	COG2200	EAL domain
EHW99_RS06165	COG0791	NLP P60 protein
EHW99_RS06170	COG0671	phosphoesterase, PA-phosphatase related
EHW99_RS06175	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHW99_RS06185	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW99_RS06185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW99_RS06190	COG1105	Belongs to the carbohydrate kinase PfkB family
EHW99_RS06195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHW99_RS06195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHW99_RS06195	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EHW99_RS06200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EHW99_RS06205	COG2855	membrane
EHW99_RS06210	COG0583	DNA-binding transcription factor activity
EHW99_RS06215	COG0833	amino acid
EHW99_RS06220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW99_RS06225	COG1120	ATPase activity
EHW99_RS06245	COG0583	DNA-binding transcription factor activity
EHW99_RS06250	COG0302	gtp cyclohydrolase
EHW99_RS06255	COG2311	Membrane
EHW99_RS06260	COG1609	Transcriptional regulator
EHW99_RS06270	COG1129	ABC transporter
EHW99_RS06280	COG2949	membrane
EHW99_RS06285	COG0281	malic enzyme
EHW99_RS06290	COG0295	cytidine deaminase activity
EHW99_RS06295	COG1346	cytolysis
EHW99_RS06300	COG1380	Effector of murein hydrolase LrgA
EHW99_RS06305	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHW99_RS06305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHW99_RS06310	COG0489	protein tyrosine kinase activity
EHW99_RS06325	COG1605	Chorismate mutase
EHW99_RS06335	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EHW99_RS06340	COG0351	phosphomethylpyrimidine kinase
EHW99_RS06345	COG1597	lipid kinase activity
EHW99_RS06365	COG0745	RESPONSE REGULATOR receiver
EHW99_RS06370	COG2205	protein histidine kinase activity
EHW99_RS06395	COG0443	Heat shock 70 kDa protein
EHW99_RS06400	COG5002	protein histidine kinase activity
EHW99_RS06400	COG5001	Diguanylate cyclase
EHW99_RS06400	COG3447	MASE1 domain protein
EHW99_RS06410	COG0572	uridine kinase
EHW99_RS06415	COG0717	Belongs to the dCTP deaminase family
EHW99_RS06420	COG2982	Protein involved in outer membrane biogenesis
EHW99_RS06425	COG1253	flavin adenine dinucleotide binding
EHW99_RS06490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EHW99_RS06525	COG1442	glycosyl transferase family 8
EHW99_RS06555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EHW99_RS06560	COG0140	phosphoribosyl-ATP diphosphatase activity
EHW99_RS06560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EHW99_RS06570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EHW99_RS06575	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EHW99_RS06580	COG0131	Imidazoleglycerol-phosphate dehydratase
EHW99_RS06580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EHW99_RS06585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EHW99_RS06595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EHW99_RS06605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW99_RS06610	COG0531	amino acid
EHW99_RS06615	COG2925	Exonuclease
EHW99_RS06625	COG1289	transmembrane transporter activity
EHW99_RS06630	COG2926	Belongs to the UPF0265 family
EHW99_RS06635	COG0534	Mate efflux family protein
EHW99_RS06645	COG0596	Alpha beta hydrolase
EHW99_RS06650	COG1280	lysine exporter protein (LysE YggA)
EHW99_RS06665	COG0077	Prephenate dehydratase
EHW99_RS06670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EHW99_RS06690	COG1522	sequence-specific DNA binding
EHW99_RS06700	COG3284	Transcriptional regulator
EHW99_RS06705	COG1063	alcohol dehydrogenase
EHW99_RS06710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EHW99_RS06750	COG0583	DNA-binding transcription factor activity
EHW99_RS06755	COG1280	lysine exporter protein (LysE YggA)
EHW99_RS06800	COG0747	negative chemotaxis
EHW99_RS06805	COG0601	transmembrane transport
EHW99_RS06810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW99_RS06815	COG4172	Belongs to the ABC transporter superfamily
EHW99_RS06825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW99_RS06855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHW99_RS06860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHW99_RS06865	COG1121	(ABC) transporter
EHW99_RS06870	COG0803	Belongs to the bacterial solute-binding protein 9 family
EHW99_RS06875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EHW99_RS06890	COG3228	Belongs to the MtfA family
EHW99_RS06900	COG1418	mRNA catabolic process
EHW99_RS06905	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EHW99_RS06915	COG3727	T/G mismatch-specific endonuclease activity
EHW99_RS06925	COG2354	Protein conserved in bacteria
EHW99_RS06930	COG5475	Uncharacterized small protein (DUF2158)
EHW99_RS06945	COG0366	Alpha amylase catalytic
EHW99_RS06955	COG1516	flagellar protein fliS
EHW99_RS06960	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EHW99_RS06965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHW99_RS06965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHW99_RS06990	COG4763	Acyl-transferase
EHW99_RS06995	COG0506	proline dehydrogenase activity
EHW99_RS06995	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EHW99_RS06995	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EHW99_RS07020	COG1702	phosphate starvation-inducible protein PhoH
EHW99_RS07035	COG0778	Nitroreductase
EHW99_RS07060	COG3381	protein complex oligomerization
EHW99_RS07070	COG1012	belongs to the aldehyde dehydrogenase family
EHW99_RS07075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EHW99_RS07080	COG1216	Glycosyl transferase, family 2
EHW99_RS07085	COG2244	polysaccharide biosynthetic process
EHW99_RS07095	COG0431	NADPH-dependent FMN reductase
EHW99_RS07100	COG0113	porphobilinogen synthase activity
EHW99_RS07155	COG0835	chemotaxis
EHW99_RS07175	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EHW99_RS07185	COG0745	RESPONSE REGULATOR receiver
EHW99_RS07195	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EHW99_RS07210	COG0018	arginyl-trna synthetase
EHW99_RS07215	COG3102	Protein conserved in bacteria
EHW99_RS07220	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EHW99_RS07225	COG3142	Participates in the control of copper homeostasis
EHW99_RS07235	COG0500	methyltransferase
EHW99_RS07240	COG2226	methyltransferase
EHW99_RS07245	COG3788	relative of glutathione S-transferase, MAPEG superfamily
EHW99_RS07250	COG1801	Protein of unknown function DUF72
EHW99_RS07255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EHW99_RS07260	COG0494	nUDIX hydrolase
EHW99_RS07265	COG0217	transcriptional regulatory protein
EHW99_RS07270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EHW99_RS07275	COG0632	four-way junction helicase activity
EHW99_RS07280	COG2255	four-way junction helicase activity
EHW99_RS07285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHW99_RS07295	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EHW99_RS07300	COG0739	heme binding
EHW99_RS07305	COG1560	Kdo2-lipid A biosynthetic process
EHW99_RS07315	COG0469	pyruvate kinase activity
EHW99_RS07320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EHW99_RS07325	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EHW99_RS07330	COG3141	response to X-ray
EHW99_RS07335	COG1082	Xylose isomerase domain protein TIM barrel
EHW99_RS07340	COG1770	oligopeptidase
EHW99_RS07345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHW99_RS07390	COG0628	permease
EHW99_RS07405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EHW99_RS07405	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EHW99_RS07410	COG3008	intermembrane lipid transfer
EHW99_RS07415	COG2995	paraquat-inducible protein a
EHW99_RS07420	COG1956	GAF domain-containing protein
EHW99_RS07425	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EHW99_RS07435	COG0501	Belongs to the peptidase M48B family
EHW99_RS07465	COG2226	methyltransferase
EHW99_RS07470	COG1253	flavin adenine dinucleotide binding
EHW99_RS07475	COG1760	l-serine dehydratase
EHW99_RS07490	COG3140	Belongs to the UPF0181 family
EHW99_RS07495	COG0251	oxidation-reduction process
EHW99_RS07500	COG1199	ATP-dependent helicase activity
EHW99_RS07510	COG3065	identical protein binding
EHW99_RS07515	COG0318	PFAM AMP-dependent synthetase and ligase
EHW99_RS07525	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EHW99_RS07530	COG2894	cell division
EHW99_RS07535	COG0850	regulation of cytokinetic process
EHW99_RS07540	COG3100	YcgL domain-containing protein
EHW99_RS07545	COG0179	Fumarylacetoacetate (FAA) hydrolase
EHW99_RS07560	COG2186	Transcriptional regulator
EHW99_RS07565	COG2719	SpoVR family
EHW99_RS07570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHW99_RS07575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHW99_RS07600	COG2718	Belongs to the UPF0229 family
EHW99_RS07605	COG2766	serine protein kinase
EHW99_RS07610	COG3713	MltA-interacting MipA family protein
EHW99_RS07615	COG0656	L-ascorbic acid biosynthetic process
EHW99_RS07630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHW99_RS07635	COG3139	Protein of unknown function (DUF1315)
EHW99_RS07640	COG1335	isochorismatase
EHW99_RS07645	COG0252	asparaginase activity
EHW99_RS07650	COG0616	signal peptide processing
EHW99_RS07655	COG0778	Nitroreductase
EHW99_RS07670	COG0708	Exodeoxyribonuclease III
EHW99_RS07705	COG0788	formyltetrahydrofolate deformylase activity
EHW99_RS07710	COG3012	SEC-C Motif Domain Protein
EHW99_RS07715	COG0745	RESPONSE REGULATOR receiver
EHW99_RS07720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EHW99_RS07770	COG2828	Protein conserved in bacteria
EHW99_RS07775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHW99_RS07780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EHW99_RS07785	COG0583	DNA-binding transcription factor activity
EHW99_RS07790	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EHW99_RS07800	COG3384	dioxygenase
EHW99_RS07815	COG2095	MarC family integral membrane protein
EHW99_RS07820	COG4166	transmembrane transport
EHW99_RS07830	COG0601	transmembrane transport
EHW99_RS07835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW99_RS07840	COG0444	Belongs to the ABC transporter superfamily
EHW99_RS07850	COG3099	Belongs to the UPF0263 family
EHW99_RS07855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHW99_RS07870	COG2350	Protein conserved in bacteria
EHW99_RS07885	COG2917	probably involved in intracellular septation
EHW99_RS07895	COG3047	cAMP biosynthetic process
EHW99_RS07905	COG0159	tryptophan synthase activity
EHW99_RS07910	COG0133	tryptophan synthase activity
EHW99_RS07920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHW99_RS07925	COG0512	Glutamine amidotransferase of anthranilate synthase
EHW99_RS07925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHW99_RS07935	COG0613	PHP domain protein
EHW99_RS07940	COG0009	L-threonylcarbamoyladenylate synthase
EHW99_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
EHW99_RS07955	COG0616	signal peptide processing
EHW99_RS07980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EHW99_RS07990	COG0671	phosphoesterase, PA-phosphatase related
EHW99_RS07995	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EHW99_RS08000	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EHW99_RS08005	COG0284	orotidine-5'-phosphate decarboxylase activity
EHW99_RS08010	COG0023	Translation Initiation Factor
EHW99_RS08025	COG0235	Class ii aldolase
EHW99_RS08030	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EHW99_RS08065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHW99_RS08065	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHW99_RS08075	COG4172	Belongs to the ABC transporter superfamily
EHW99_RS08080	COG4172	Belongs to the ABC transporter superfamily
EHW99_RS08085	COG4171	peptide transport system, permease
EHW99_RS08090	COG4168	peptide transport system, permease
EHW99_RS08100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EHW99_RS08105	COG1842	Phage shock protein A
EHW99_RS08115	COG1983	PspC domain protein
EHW99_RS08125	COG3106	COG3106 Predicted ATPase
EHW99_RS08130	COG3768	UPF0283 membrane protein
EHW99_RS08145	COG4948	Mandelate Racemase Muconate Lactonizing
EHW99_RS08150	COG4166	transmembrane transport
EHW99_RS08170	COG3188	usher protein
EHW99_RS08175	COG3121	Chaperone
EHW99_RS08180	COG3539	Fimbrial protein
EHW99_RS08190	COG0366	Alpha amylase catalytic
EHW99_RS08195	COG0037	tRNA processing
EHW99_RS08205	COG0513	Belongs to the DEAD box helicase family
EHW99_RS08220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHW99_RS08225	COG2911	Protein conserved in bacteria
EHW99_RS08235	COG3784	Protein of unknown function (DUF1318)
EHW99_RS08240	COG1028	Short-chain dehydrogenase reductase Sdr
EHW99_RS08245	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EHW99_RS08250	COG1643	Atp-dependent helicase
EHW99_RS08255	COG3023	N-Acetylmuramoyl-L-alanine amidase
EHW99_RS08260	COG3591	Belongs to the peptidase S1B family
EHW99_RS08270	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EHW99_RS08275	COG2205	protein histidine kinase activity
EHW99_RS08280	COG0582	viral genome integration into host DNA
EHW99_RS08320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EHW99_RS08335	COG0745	RESPONSE REGULATOR receiver
EHW99_RS08345	COG0531	amino acid
EHW99_RS08360	COG3182	Iron-regulated membrane protein
EHW99_RS08385	COG2840	Smr protein MutS2
EHW99_RS08405	COG2814	Major facilitator Superfamily
EHW99_RS08425	COG2195	Cleaves the N-terminal amino acid of tripeptides
EHW99_RS08430	COG0747	negative chemotaxis
EHW99_RS08440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW99_RS08470	COG2814	Major facilitator Superfamily
EHW99_RS08480	COG3708	Transcriptional regulator
EHW99_RS08480	COG2207	Transcriptional regulator
EHW99_RS08495	COG4290	ribonuclease
EHW99_RS08515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW99_RS08555	COG0840	transmembrane signaling receptor activity
EHW99_RS08605	COG1309	transcriptional regulator
EHW99_RS08620	COG4771	TonB-dependent receptor
EHW99_RS08620	COG1629	transport
EHW99_RS08620	COG1629	transport
EHW99_RS08620	COG4771	TonB-dependent receptor
EHW99_RS08630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EHW99_RS08635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EHW99_RS08645	COG2707	UPF0756 membrane protein
EHW99_RS08660	COG0339	signal peptide processing
EHW99_RS08665	COG0402	S-adenosylhomocysteine deaminase activity
EHW99_RS08670	COG4221	oxidoreductase activity
EHW99_RS08685	COG0477	Major facilitator Superfamily
EHW99_RS08695	COG1940	carbohydrate kinase activity
EHW99_RS08700	COG0583	DNA-binding transcription factor activity
EHW99_RS08705	COG2814	Major facilitator Superfamily
EHW99_RS08725	COG5339	Protein conserved in bacteria
EHW99_RS08730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EHW99_RS08735	COG0673	inositol 2-dehydrogenase activity
EHW99_RS08745	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW99_RS08755	COG1879	ABC-type sugar transport system periplasmic component
EHW99_RS08760	COG1069	ribulokinase activity
EHW99_RS08765	COG2160	L-arabinose isomerase activity
EHW99_RS08775	COG4657	Part of a membrane complex involved in electron transport
EHW99_RS08780	COG2878	Part of a membrane complex involved in electron transport
EHW99_RS08785	COG4656	Part of a membrane complex involved in electron transport
EHW99_RS08790	COG4658	electron transport chain
EHW99_RS08795	COG4659	FMN binding
EHW99_RS08800	COG4660	Part of a membrane complex involved in electron transport
EHW99_RS08805	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EHW99_RS08820	COG1309	transcriptional regulator
EHW99_RS08830	COG0625	glutathione transferase activity
EHW99_RS08840	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EHW99_RS08845	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EHW99_RS08850	COG0259	pyridoxamine-phosphate oxidase activity
EHW99_RS08855	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EHW99_RS08875	COG3313	Fe-S protein
EHW99_RS08895	COG2194	sulfuric ester hydrolase activity
EHW99_RS08905	COG1902	pentaerythritol trinitrate reductase activity
EHW99_RS08910	COG0346	lactoylglutathione lyase activity
EHW99_RS08920	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EHW99_RS08925	COG0791	NLP P60 protein
EHW99_RS08930	COG1609	Transcriptional regulator
EHW99_RS08935	COG0583	DNA-binding transcription factor activity
EHW99_RS08940	COG2814	Major facilitator Superfamily
EHW99_RS08945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHW99_RS08950	COG0307	riboflavin synthase, alpha
EHW99_RS08970	COG0469	pyruvate kinase activity
EHW99_RS08980	COG2166	iron-sulfur cluster assembly
EHW99_RS08990	COG0719	Fe-S assembly protein
EHW99_RS08995	COG0396	ATPase activity
EHW99_RS09000	COG0719	Fe-S assembly protein
EHW99_RS09005	COG0316	Belongs to the HesB IscA family
EHW99_RS09015	COG0247	lactate metabolic process
EHW99_RS09015	COG0277	FAD linked oxidase domain protein
EHW99_RS09020	COG0628	permease
EHW99_RS09030	COG0574	Belongs to the PEP-utilizing enzyme family
EHW99_RS09030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHW99_RS09035	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EHW99_RS09045	COG3720	iron ion transport
EHW99_RS09050	COG4558	Periplasmic binding protein
EHW99_RS09055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW99_RS09060	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EHW99_RS09065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EHW99_RS09080	COG0791	NLP P60 protein
EHW99_RS09085	COG0386	Belongs to the glutathione peroxidase family
EHW99_RS09095	COG0776	regulation of translation
EHW99_RS09105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EHW99_RS09115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EHW99_RS09120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EHW99_RS09130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EHW99_RS09135	COG3137	Salt-induced outer membrane protein
EHW99_RS09145	COG3001	Fructosamine kinase
EHW99_RS09155	COG1988	membrane-bound metal-dependent
EHW99_RS09170	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW99_RS09175	COG2814	Major facilitator Superfamily
EHW99_RS09180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EHW99_RS09185	COG0322	excinuclease ABC activity
EHW99_RS09190	COG3678	ATP-independent chaperone mediated protein folding
EHW99_RS09195	COG2988	succinylglutamate desuccinylase activity
EHW99_RS09200	COG3724	N-succinylarginine dihydrolase activity
EHW99_RS09205	COG1012	belongs to the aldehyde dehydrogenase family
EHW99_RS09220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EHW99_RS09225	COG4932	domain protein
EHW99_RS09255	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EHW99_RS09285	COG0387	Pfam Sodium calcium exchanger
EHW99_RS09290	COG3187	Heat shock protein
EHW99_RS09295	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EHW99_RS09300	COG2912	Transglutaminase-like superfamily
EHW99_RS09310	COG2890	protein-(glutamine-N5) methyltransferase activity
EHW99_RS09315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EHW99_RS09320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EHW99_RS09325	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EHW99_RS09330	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EHW99_RS09345	COG0193	aminoacyl-tRNA hydrolase activity
EHW99_RS09355	COG0659	secondary active sulfate transmembrane transporter activity
EHW99_RS09360	COG0012	GTP binding
EHW99_RS09370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHW99_RS09520	COG3290	protein histidine kinase activity
EHW99_RS09525	COG4565	transcriptional regulatory protein
EHW99_RS09545	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EHW99_RS09545	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EHW99_RS09560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EHW99_RS09570	COG2261	transglycosylase associated protein
EHW99_RS09575	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EHW99_RS09580	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
EHW99_RS09590	COG1619	proteins homologs of microcin C7 resistance protein MccF
EHW99_RS09630	COG0538	isocitrate dehydrogenase activity
EHW99_RS09650	COG2915	High frequency lysogenization protein hflD homolog
EHW99_RS09655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EHW99_RS09660	COG0745	RESPONSE REGULATOR receiver
EHW99_RS09670	COG2850	peptidyl-arginine hydroxylation
EHW99_RS09675	COG1396	sequence-specific DNA binding
EHW99_RS09680	COG3135	benzoate transporter
EHW99_RS09690	COG1940	carbohydrate kinase activity
EHW99_RS09700	COG4591	ABC-type transport system involved in lipoprotein release permease component
EHW99_RS09710	COG4591	ABC-type transport system involved in lipoprotein release permease component
EHW99_RS09715	COG2199	diguanylate cyclase activity
EHW99_RS09735	COG0835	chemotaxis
EHW99_RS09735	COG0784	Response regulator, receiver
EHW99_RS09740	COG1677	Flagellar hook-basal body complex protein FliE
EHW99_RS09750	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHW99_RS09755	COG1317	bacterial-type flagellum organization
EHW99_RS09775	COG1580	Controls the rotational direction of flagella during chemotaxis
EHW99_RS09780	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EHW99_RS09830	COG1215	transferase activity, transferring glycosyl groups
EHW99_RS09835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EHW99_RS09840	COG3134	Outer membrane lipoprotein
EHW99_RS09845	COG1252	NADH dehydrogenase
EHW99_RS09855	COG1472	Belongs to the glycosyl hydrolase 3 family
EHW99_RS09865	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
EHW99_RS09875	COG0537	adenosine 5'-monophosphoramidase activity
EHW99_RS09880	COG1263	PTS System
EHW99_RS09880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHW99_RS09885	COG0084	hydrolase, TatD family'
EHW99_RS09890	COG0470	DNA polymerase III
EHW99_RS09895	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EHW99_RS09900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EHW99_RS09905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EHW99_RS09910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHW99_RS09915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHW99_RS09925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EHW99_RS09930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EHW99_RS09935	COG0416	fatty acid biosynthetic process
EHW99_RS09940	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EHW99_RS09945	COG1399	metal-binding, possibly nucleic acid-binding protein
EHW99_RS09950	COG0424	maF-like protein
EHW99_RS09955	COG0564	pseudouridine synthase activity
EHW99_RS09960	COG1530	ribonuclease E activity
EHW99_RS09960	COG1530	ribonuclease E activity
EHW99_RS09965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EHW99_RS09970	COG1256	bacterial-type flagellum assembly
EHW99_RS10000	COG1749	Flagellar hook protein flgE
EHW99_RS10005	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EHW99_RS10010	COG1558	bacterial-type flagellum-dependent cell motility
EHW99_RS10015	COG1815	bacterial-type flagellum-dependent cell motility
EHW99_RS10030	COG3418	PFAM FlgN family protein
EHW99_RS10045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW99_RS10050	COG2999	glutathione oxidoreductase activity
EHW99_RS10060	COG0418	dihydroorotase activity
EHW99_RS10080	COG3038	cytochrome b561
EHW99_RS10095	COG1560	Kdo2-lipid A biosynthetic process
EHW99_RS10105	COG5645	(Lipo)protein
EHW99_RS10125	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHW99_RS10155	COG1846	Transcriptional regulator
EHW99_RS10180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EHW99_RS10185	COG0322	excinuclease ABC activity
EHW99_RS10190	COG2197	response regulator
EHW99_RS10200	COG3136	membrane protein required for alginate biosynthesis
EHW99_RS10210	COG2197	response regulator
EHW99_RS10215	COG1113	amino acid transport
EHW99_RS10225	COG1309	transcriptional regulator
EHW99_RS10240	COG1012	belongs to the aldehyde dehydrogenase family
EHW99_RS10265	COG0670	Belongs to the BI1 family
EHW99_RS10270	COG2920	part of a sulfur-relay system
EHW99_RS10280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHW99_RS10285	COG3785	DNA binding
EHW99_RS10295	COG1803	Methylglyoxal synthase
EHW99_RS10300	COG0210	DNA helicase
EHW99_RS10305	COG3304	Inner membrane component domain
EHW99_RS10310	COG1289	transmembrane transporter activity
EHW99_RS10315	COG3070	regulator of competence-specific genes
EHW99_RS10325	COG2885	chlorophyll binding
EHW99_RS10325	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EHW99_RS10330	COG3120	sequence-specific DNA binding
EHW99_RS10335	COG1067	ATP-dependent peptidase activity
EHW99_RS10340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EHW99_RS10345	COG3130	regulation of translation
EHW99_RS10350	COG3009	Protein conserved in bacteria
EHW99_RS10355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHW99_RS10355	COG3008	intermembrane lipid transfer
EHW99_RS10360	COG2995	paraquat-inducible protein a
EHW99_RS10365	COG0488	(ABC) transporter
EHW99_RS10370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EHW99_RS10370	COG0116	Belongs to the methyltransferase superfamily
EHW99_RS10375	COG3217	Mosc domain protein beta barrel domain protein
EHW99_RS10375	COG0633	Ferredoxin
EHW99_RS10385	COG0167	dihydroorotate dehydrogenase activity
EHW99_RS10390	COG0431	NADPH-dependent FMN reductase
EHW99_RS10395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHW99_RS10405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW99_RS10415	COG0308	aminopeptidase N
EHW99_RS10420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EHW99_RS10425	COG0017	Asparaginyl-tRNA synthetase
EHW99_RS10435	COG1448	Aminotransferase
EHW99_RS10440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHW99_RS10445	COG3108	Peptidase M15
EHW99_RS10450	COG2989	Protein conserved in bacteria
EHW99_RS10455	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EHW99_RS10460	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EHW99_RS10465	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EHW99_RS10470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHW99_RS10475	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EHW99_RS10480	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EHW99_RS10485	COG2835	tetraacyldisaccharide 4'-kinase activity
EHW99_RS10490	COG1663	tetraacyldisaccharide 4'-kinase activity
EHW99_RS10500	COG0658	competence protein
EHW99_RS10500	COG2333	competence protein COMEC
EHW99_RS10505	COG0776	regulation of translation
EHW99_RS10510	COG0539	negative regulation of cytoplasmic translation
EHW99_RS10515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EHW99_RS10520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EHW99_RS10525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EHW99_RS10530	COG1944	ATP diphosphatase activity
EHW99_RS10540	COG0477	Major facilitator Superfamily
EHW99_RS10545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EHW99_RS10550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EHW99_RS10555	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EHW99_RS10560	COG3107	peptidoglycan biosynthetic process
EHW99_RS10560	COG1674	ftsk spoiiie
EHW99_RS10570	COG0492	ferredoxin-NADP+ reductase activity
EHW99_RS10575	COG4988	ABC transporter
EHW99_RS10580	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EHW99_RS10585	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EHW99_RS10590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EHW99_RS10595	COG0542	response to heat
EHW99_RS10600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EHW99_RS10610	COG1278	Cold shock
EHW99_RS10615	COG3593	DNA synthesis involved in DNA repair
EHW99_RS10620	COG0028	Belongs to the TPP enzyme family
EHW99_RS10625	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EHW99_RS10635	COG3023	N-Acetylmuramoyl-L-alanine amidase
EHW99_RS10640	COG0393	Putative heavy-metal-binding
EHW99_RS10650	COG1126	abc transporter atp-binding protein
EHW99_RS10655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW99_RS10660	COG4215	(ABC) transporter
EHW99_RS10665	COG4160	amino acid transport
EHW99_RS10670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW99_RS10680	COG1177	transmembrane transport
EHW99_RS10685	COG1176	ABC-type spermidine putrescine transport system, permease component I
EHW99_RS10690	COG3842	ATPase activity
EHW99_RS10695	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EHW99_RS10730	COG0814	amino acid
EHW99_RS10735	COG1686	Belongs to the peptidase S11 family
EHW99_RS10755	COG4172	Belongs to the ABC transporter superfamily
EHW99_RS10765	COG0303	'Molybdopterin
EHW99_RS10775	COG0488	(ABC) transporter
EHW99_RS10780	COG2814	Major facilitator Superfamily
EHW99_RS10795	COG2814	Major facilitator Superfamily
EHW99_RS10800	COG1566	PFAM secretion protein HlyD family protein
EHW99_RS10805	COG1321	iron dependent repressor
EHW99_RS10810	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EHW99_RS10820	COG0783	Belongs to the Dps family
EHW99_RS10825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EHW99_RS10830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW99_RS10835	COG0765	amino acid transport
EHW99_RS10840	COG1126	abc transporter atp-binding protein
EHW99_RS10850	COG0668	transmembrane transport
EHW99_RS10855	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EHW99_RS10865	COG0641	radical SAM
EHW99_RS10880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EHW99_RS10885	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
EHW99_RS10895	COG1228	amidohydrolase
EHW99_RS10900	COG0402	S-adenosylhomocysteine deaminase activity
EHW99_RS10915	COG2986	histidine ammonia-lyase
EHW99_RS10920	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EHW99_RS10925	COG1473	amidohydrolase
EHW99_RS10930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHW99_RS10950	COG0789	Transcriptional regulator
EHW99_RS10960	COG4221	oxidoreductase activity
EHW99_RS10975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHW99_RS10995	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EHW99_RS11010	COG0277	FAD linked oxidase domain protein
EHW99_RS11020	COG1511	domain protein
EHW99_RS11020	COG3264	Mechanosensitive ion channel
EHW99_RS11025	COG1686	Belongs to the peptidase S11 family
EHW99_RS11035	COG0586	Pfam SNARE associated Golgi protein
EHW99_RS11040	COG3387	PFAM Glycoside hydrolase 15-related
EHW99_RS11045	COG1376	ErfK ybiS ycfS ynhG family protein
EHW99_RS11050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EHW99_RS11055	COG0513	Belongs to the DEAD box helicase family
EHW99_RS11065	COG0670	Belongs to the BI1 family
EHW99_RS11080	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EHW99_RS11085	COG0315	cyclic pyranopterin monophosphate synthase activity
EHW99_RS11090	COG0521	Mo-molybdopterin cofactor biosynthetic process
EHW99_RS11105	COG0556	nucleotide-excision repair
EHW99_RS11115	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EHW99_RS11125	COG0156	8-amino-7-oxononanoate synthase activity
EHW99_RS11130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EHW99_RS11140	COG2130	NADP-dependent
EHW99_RS11145	COG1881	PFAM PEBP family protein
EHW99_RS11150	COG2706	6-phosphogluconolactonase activity
EHW99_RS11155	COG0561	phosphatase activity
EHW99_RS11165	COG4149	molybdate abc transporter
EHW99_RS11170	COG0725	ABC transporter, periplasmic molybdate-binding protein
EHW99_RS11180	COG3585	molybdate ion transport
EHW99_RS11180	COG2005	Transcriptional regulator
EHW99_RS11185	COG1119	ATPase activity
EHW99_RS11195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EHW99_RS11200	COG2017	converts alpha-aldose to the beta-anomer
EHW99_RS11205	COG0588	phosphoglycerate mutase activity
EHW99_RS11225	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHW99_RS11235	COG1230	cation diffusion facilitator family transporter
EHW99_RS11300	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EHW99_RS11305	COG2885	chlorophyll binding
EHW99_RS11310	COG0823	Involved in the tonB-independent uptake of proteins
EHW99_RS11315	COG3064	Membrane
EHW99_RS11320	COG0848	biopolymer transport protein
EHW99_RS11325	COG0811	peptide transport
EHW99_RS11330	COG0824	Thioesterase
EHW99_RS11335	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EHW99_RS11340	COG0045	succinate-CoA ligase (ADP-forming) activity
EHW99_RS11345	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW99_RS11350	COG0567	Dehydrogenase, E1 component
EHW99_RS11355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EHW99_RS11360	COG1053	succinate dehydrogenase
EHW99_RS11365	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EHW99_RS11370	COG2009	succinate dehydrogenase
EHW99_RS11375	COG0372	Belongs to the citrate synthase family
EHW99_RS11385	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EHW99_RS11390	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EHW99_RS11395	COG1984	allophanate hydrolase subunit 2
EHW99_RS11400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EHW99_RS11410	COG0415	Belongs to the DNA photolyase family
EHW99_RS11415	COG3272	Protein of unknown function (DUF1722)
EHW99_RS11425	COG0745	RESPONSE REGULATOR receiver
EHW99_RS11430	COG0033	Phosphoglucomutase
EHW99_RS11435	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EHW99_RS11440	COG0596	Alpha beta hydrolase
EHW99_RS11455	COG0735	belongs to the Fur family
EHW99_RS11460	COG0814	amino acid
EHW99_RS11465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHW99_RS11475	COG0363	glucosamine-6-phosphate deaminase activity
EHW99_RS11480	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EHW99_RS11485	COG1940	carbohydrate kinase activity
EHW99_RS11485	COG1846	Transcriptional regulator
EHW99_RS11490	COG0647	UMP catabolic process
EHW99_RS11495	COG0367	asparagine synthase
EHW99_RS11530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW99_RS11535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EHW99_RS11540	COG1702	phosphate starvation-inducible protein PhoH
EHW99_RS11545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EHW99_RS11550	COG4535	Mg2 and Co2 transporter CorC
EHW99_RS11555	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EHW99_RS11565	COG0765	amino acid transport
EHW99_RS11570	COG0765	amino acid transport
EHW99_RS11575	COG1126	abc transporter atp-binding protein
EHW99_RS11580	COG2888	peptidyl-tyrosine sulfation
EHW99_RS11585	COG0495	leucyl-tRNA aminoacylation
EHW99_RS11590	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EHW99_RS11595	COG1466	dna polymerase III delta subunit
EHW99_RS11605	COG0799	negative regulation of ribosome biogenesis
EHW99_RS11610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EHW99_RS11615	COG0768	penicillin binding
EHW99_RS11620	COG0772	Belongs to the SEDS family
EHW99_RS11625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EHW99_RS11630	COG1686	Belongs to the peptidase S11 family
EHW99_RS11635	COG2921	Belongs to the UPF0250 family
EHW99_RS11640	COG0321	lipoyl(octanoyl) transferase activity
EHW99_RS11645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EHW99_RS11650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHW99_RS11655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHW99_RS11670	COG2610	gluconate transmembrane transporter activity
EHW99_RS11675	COG2610	gluconate transmembrane transporter activity
EHW99_RS11680	COG3622	Belongs to the hyi family
EHW99_RS11685	COG0235	Class ii aldolase
EHW99_RS11690	COG3395	kinase activity
EHW99_RS11695	COG2084	Dehydrogenase
EHW99_RS11700	COG1349	DNA-binding transcription factor activity
EHW99_RS11715	COG1271	oxidase subunit
EHW99_RS11720	COG1294	oxidase, subunit
EHW99_RS11730	COG2076	Multidrug Resistance protein
EHW99_RS11735	COG2076	Multidrug Resistance protein
EHW99_RS11740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EHW99_RS11745	COG0726	polysaccharide deacetylase
EHW99_RS11750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHW99_RS11750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW99_RS11755	COG0463	Glycosyl transferase, family 2
EHW99_RS11760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHW99_RS11770	COG4993	Dehydrogenase
EHW99_RS11775	COG4772	TonB-dependent receptor
EHW99_RS11790	COG4172	Belongs to the ABC transporter superfamily
EHW99_RS11810	COG1410	methionine synthase
EHW99_RS11810	COG0646	methionine synthase
EHW99_RS11825	COG1764	response to oxidative stress
EHW99_RS11850	COG0582	viral genome integration into host DNA
EHW99_RS11860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EHW99_RS11865	COG2501	S4 domain
EHW99_RS11870	COG1064	alcohol dehydrogenase
EHW99_RS11875	COG0215	cysteine-tRNA ligase activity
EHW99_RS11880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHW99_RS11890	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EHW99_RS11895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EHW99_RS11900	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EHW99_RS11905	COG4181	ATPase activity
EHW99_RS11910	COG2755	lipolytic protein G-D-S-L family
EHW99_RS11935	COG0300	oxidoreductase activity
EHW99_RS11940	COG3118	belongs to the thioredoxin family
EHW99_RS11945	COG0330	HflC and HflK could
EHW99_RS11950	COG1585	Membrane protein implicated in regulation of membrane protease activity
EHW99_RS11960	COG2217	Heavy metal translocating P-type atpase
EHW99_RS11965	COG3735	TraB family
EHW99_RS11970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EHW99_RS11975	COG0583	DNA-binding transcription factor activity
EHW99_RS11985	COG0737	Belongs to the 5'-nucleotidase family
EHW99_RS11990	COG2223	nitrite transmembrane transporter activity
EHW99_RS11995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EHW99_RS11995	COG4651	solute:proton antiporter activity
EHW99_RS12005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW99_RS12010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EHW99_RS12015	COG0563	adenylate kinase activity
EHW99_RS12040	COG0583	DNA-binding transcription factor activity
EHW99_RS12045	COG0326	Molecular chaperone. Has ATPase activity
EHW99_RS12050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EHW99_RS12055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EHW99_RS12065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EHW99_RS12070	COG2832	Protein of unknown function (DUF454)
EHW99_RS12090	COG1309	transcriptional regulator
EHW99_RS12095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EHW99_RS12100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW99_RS12105	COG0254	rRNA binding
EHW99_RS12110	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EHW99_RS12135	COG3695	enzyme binding
EHW99_RS12140	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EHW99_RS12145	COG1946	Acyl-CoA thioesterase
EHW99_RS12150	COG0004	ammonium transporteR
EHW99_RS12155	COG0347	Belongs to the P(II) protein family
EHW99_RS12160	COG1132	(ABC) transporter
EHW99_RS12165	COG1132	(ABC) transporter
EHW99_RS12170	COG1522	sequence-specific DNA binding
EHW99_RS12180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EHW99_RS12185	COG0824	Thioesterase
EHW99_RS12190	COG1555	photosystem II stabilization
EHW99_RS12195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EHW99_RS12200	COG0776	regulation of translation
EHW99_RS12215	COG0740	serine-type endopeptidase activity
EHW99_RS12230	COG0544	peptidyl-prolyl cis-trans isomerase activity
EHW99_RS12235	COG0271	Belongs to the BolA IbaG family
EHW99_RS12240	COG3056	Lipoprotein
EHW99_RS12245	COG2223	nitrite transmembrane transporter activity
EHW99_RS12250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHW99_RS12255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHW99_RS12260	COG1845	cytochrome c oxidase, subunit III
EHW99_RS12265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EHW99_RS12270	COG0109	protoheme IX farnesyltransferase activity
EHW99_RS12275	COG2814	Major facilitator Superfamily
EHW99_RS12280	COG1666	GTP binding
EHW99_RS12285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EHW99_RS12295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHW99_RS12295	COG0301	tRNA thio-modification
EHW99_RS12300	COG1722	exodeoxyribonuclease VII activity
EHW99_RS12305	COG0142	geranyltranstransferase activity
EHW99_RS12310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EHW99_RS12315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EHW99_RS12320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EHW99_RS12325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHW99_RS12330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EHW99_RS12335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHW99_RS12335	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EHW99_RS12340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EHW99_RS12345	COG1652	LysM domain
EHW99_RS12355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHW99_RS12360	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHW99_RS12365	COG1862	Preprotein translocase
EHW99_RS12370	COG0343	queuine tRNA-ribosyltransferase activity
EHW99_RS12375	COG2246	polysaccharide biosynthetic process
EHW99_RS12390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EHW99_RS12395	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EHW99_RS12400	COG0450	alkyl hydroperoxide reductase
EHW99_RS12415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHW99_RS12425	COG5002	protein histidine kinase activity
EHW99_RS12435	COG0420	3'-5' exonuclease activity
EHW99_RS12440	COG0419	ATPase involved in DNA repair
EHW99_RS12480	COG2974	May be involved in recombination
EHW99_RS12485	COG3123	guanosine phosphorylase activity
EHW99_RS12490	COG4126	flavin adenine dinucleotide binding
EHW99_RS12515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHW99_RS12520	COG3416	Protein conserved in bacteria
EHW99_RS12525	COG1671	Belongs to the UPF0178 family
EHW99_RS12530	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EHW99_RS12545	COG3250	beta-galactosidase activity
EHW99_RS12550	COG1278	Cold shock
EHW99_RS12570	COG0747	negative chemotaxis
EHW99_RS12575	COG0601	transmembrane transport
EHW99_RS12585	COG0444	Belongs to the ABC transporter superfamily
EHW99_RS12590	COG4608	Belongs to the ABC transporter superfamily
EHW99_RS12645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EHW99_RS12650	COG2832	Protein of unknown function (DUF454)
EHW99_RS12655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EHW99_RS12660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EHW99_RS12680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EHW99_RS12685	COG2195	Cleaves the N-terminal amino acid of tripeptides
EHW99_RS12695	COG3034	peptidoglycan biosynthetic process
EHW99_RS12700	COG0121	glutamine amidotransferase
EHW99_RS12705	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EHW99_RS12710	COG1960	acyl-CoA dehydrogenase activity
EHW99_RS12715	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EHW99_RS12725	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EHW99_RS12730	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
EHW99_RS12750	COG0436	Aminotransferase
EHW99_RS12755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHW99_RS12760	COG2233	PERMEase
EHW99_RS12765	COG2351	hydroxyisourate hydrolase activity
EHW99_RS12780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EHW99_RS12795	COG0765	amino acid transport
EHW99_RS12835	COG1715	Restriction endonuclease
EHW99_RS12840	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EHW99_RS12865	COG1953	Uracil, thiamine, allantoin
EHW99_RS12875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EHW99_RS12880	COG0328	RNA-DNA hybrid ribonuclease activity
EHW99_RS12885	COG2226	methyltransferase
EHW99_RS12890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHW99_RS12895	COG0741	lytic transglycosylase activity
EHW99_RS12895	COG1388	LysM domain
EHW99_RS12905	COG3021	interspecies interaction between organisms
EHW99_RS12940	COG0542	response to heat
EHW99_RS12950	COG0564	pseudouridine synthase activity
EHW99_RS12955	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EHW99_RS12960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EHW99_RS12965	COG1605	Chorismate mutase
EHW99_RS12965	COG0077	Prephenate dehydratase
EHW99_RS12970	COG0287	Prephenate dehydrogenase
EHW99_RS12970	COG1605	Chorismate mutase
EHW99_RS12975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHW99_RS12995	COG0335	large ribosomal subunit rRNA binding
EHW99_RS13010	COG0228	four-way junction DNA binding
EHW99_RS13015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EHW99_RS13020	COG4137	Cytochrome C assembly protein
EHW99_RS13025	COG4536	flavin adenine dinucleotide binding
EHW99_RS13035	COG2918	glutathione biosynthetic process
EHW99_RS13040	COG1238	metal cluster binding
EHW99_RS13045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EHW99_RS13070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EHW99_RS13085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EHW99_RS13090	COG1546	Belongs to the CinA family
EHW99_RS13095	COG2951	lytic endotransglycosylase activity
EHW99_RS13100	COG5455	response to cobalt ion
EHW99_RS13120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHW99_RS13260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EHW99_RS13265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EHW99_RS13270	COG1388	LysM domain
EHW99_RS13270	COG4942	peptidase
EHW99_RS13275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EHW99_RS13280	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EHW99_RS13285	COG0585	pseudouridine synthase activity
EHW99_RS13290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EHW99_RS13295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EHW99_RS13300	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EHW99_RS13310	COG0529	Catalyzes the synthesis of activated sulfate
EHW99_RS13315	COG2895	sulfate adenylyltransferase (ATP) activity
EHW99_RS13320	COG0175	sulfate reduction
EHW99_RS13325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EHW99_RS13325	COG1648	precorrin-2 dehydrogenase activity
EHW99_RS13335	COG0175	sulfate reduction
EHW99_RS13340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHW99_RS13350	COG0720	synthase
EHW99_RS13360	COG0765	amino acid transport
EHW99_RS13365	COG1126	abc transporter atp-binding protein
EHW99_RS13370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW99_RS13375	COG0602	queuosine metabolic process
EHW99_RS13380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EHW99_RS13380	COG2755	lipolytic protein G-D-S-L family
EHW99_RS13385	COG0148	phosphopyruvate hydratase activity
EHW99_RS13390	COG0504	CTP synthase activity
EHW99_RS13395	COG3956	TIGRFAM MazG family protein
EHW99_RS13400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHW99_RS13405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHW99_RS13415	COG1929	Belongs to the glycerate kinase type-1 family
EHW99_RS13420	COG0716	FMN binding
EHW99_RS13425	COG0564	pseudouridine synthase activity
EHW99_RS13430	COG3098	single-species biofilm formation
EHW99_RS13440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EHW99_RS13440	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EHW99_RS13445	COG1611	Belongs to the LOG family
EHW99_RS13450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EHW99_RS13455	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EHW99_RS13460	COG2363	Small membrane protein
EHW99_RS13465	COG0583	DNA-binding transcription factor activity
EHW99_RS13475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EHW99_RS13480	COG2166	iron-sulfur cluster assembly
EHW99_RS13485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EHW99_RS13490	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EHW99_RS13510	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHW99_RS13515	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EHW99_RS13515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHW99_RS13525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EHW99_RS13530	COG1074	ATP-dependent DNA helicase activity
EHW99_RS13540	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EHW99_RS13555	COG4795	General secretion pathway protein
EHW99_RS13565	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EHW99_RS13570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EHW99_RS13575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EHW99_RS13585	COG1051	belongs to the nudix hydrolase family
EHW99_RS13590	COG3066	DNA modification
EHW99_RS13595	COG0861	Integral membrane protein TerC family
EHW99_RS13605	COG0667	Aldo Keto reductase
EHW99_RS13615	COG0318	PFAM AMP-dependent synthetase and ligase
EHW99_RS13615	COG0204	Acyl-transferase
EHW99_RS13640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW99_RS13650	COG0768	penicillin binding
EHW99_RS13655	COG2831	hemolysin activation secretion protein
EHW99_RS13660	COG3210	domain, Protein
EHW99_RS13675	COG3210	domain, Protein
EHW99_RS13690	COG3210	domain, Protein
EHW99_RS13705	COG3210	domain, Protein
EHW99_RS13720	COG3210	domain, Protein
EHW99_RS13735	COG1609	Transcriptional regulator
EHW99_RS13745	COG0583	DNA-binding transcription factor activity
EHW99_RS13750	COG2814	Major facilitator Superfamily
EHW99_RS13760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EHW99_RS13770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EHW99_RS13780	COG4974	Belongs to the 'phage' integrase family
EHW99_RS13790	COG0697	spore germination
EHW99_RS13795	COG0716	FMN binding
EHW99_RS13805	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EHW99_RS13810	COG0354	folic acid binding
EHW99_RS13815	COG1272	protein, Hemolysin III
EHW99_RS13825	COG1028	Short-chain dehydrogenase reductase Sdr
EHW99_RS13830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHW99_RS13830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EHW99_RS13835	COG0509	glycine decarboxylation via glycine cleavage system
EHW99_RS13840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EHW99_RS13845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW99_RS13850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW99_RS13855	COG0006	proline dipeptidase activity
EHW99_RS13860	COG3079	Belongs to the UPF0149 family
EHW99_RS13865	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EHW99_RS13875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EHW99_RS13880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHW99_RS13890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EHW99_RS13895	COG0583	DNA-binding transcription factor activity
EHW99_RS13905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHW99_RS13915	COG0673	inositol 2-dehydrogenase activity
EHW99_RS13930	COG2072	flavoprotein involved in K transport
EHW99_RS13945	COG0668	transmembrane transport
EHW99_RS13950	COG0191	fructose-bisphosphate aldolase activity
EHW99_RS13955	COG0126	phosphoglycerate kinase activity
EHW99_RS13960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EHW99_RS13965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EHW99_RS13970	COG0501	Belongs to the peptidase M48B family
EHW99_RS14010	COG1166	arginine decarboxylase activity
EHW99_RS14015	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EHW99_RS14020	COG2814	Major facilitator Superfamily
EHW99_RS14025	COG3091	SprT-like family
EHW99_RS14030	COG2356	endonuclease I
EHW99_RS14035	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EHW99_RS14045	COG1678	Uncharacterized ACR, COG1678
EHW99_RS14050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EHW99_RS14060	COG4232	protein-disulfide reductase activity
EHW99_RS14075	COG2805	Type II/IV secretion system protein
EHW99_RS14080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EHW99_RS14085	COG0762	integral membrane protein
EHW99_RS14090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EHW99_RS14095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EHW99_RS14105	COG3171	Protein conserved in bacteria
EHW99_RS14120	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EHW99_RS14125	COG0741	lytic transglycosylase activity
EHW99_RS14135	COG1982	Orn Lys Arg decarboxylase major
EHW99_RS14200	COG3179	chitinase
EHW99_RS14220	COG0583	DNA-binding transcription factor activity
EHW99_RS14235	COG5297	Belongs to the glycosyl hydrolase family 6
EHW99_RS14325	COG2197	response regulator
EHW99_RS14355	COG1157	protein secretion by the type III secretion system
EHW99_RS14380	COG4794	Type iii secretion
EHW99_RS14390	COG4792	protein secretion
EHW99_RS14405	COG0151	Belongs to the GarS family
EHW99_RS14410	COG0151	Belongs to the GarS family
EHW99_RS14415	COG1834	amidinotransferase
EHW99_RS14445	COG1966	Carbon starvation protein
EHW99_RS14450	COG2879	small protein
EHW99_RS14460	COG3275	phosphorelay sensor kinase activity
EHW99_RS14480	COG1522	sequence-specific DNA binding
EHW99_RS14505	COG1609	Transcriptional regulator
EHW99_RS14515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EHW99_RS14520	COG1447	Phosphotransferase system cellobiose-specific component IIA
EHW99_RS14525	COG2723	6-phospho-beta-galactosidase activity
EHW99_RS14530	COG2723	6-phospho-beta-galactosidase activity
EHW99_RS14545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EHW99_RS14555	COG1528	Iron-storage protein
EHW99_RS14565	COG0671	phosphoesterase, PA-phosphatase related
EHW99_RS14590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHW99_RS14620	COG1028	Short-chain dehydrogenase reductase Sdr
EHW99_RS14630	COG0848	biopolymer transport protein
EHW99_RS14640	COG0626	cystathionine gamma-synthase activity
EHW99_RS14645	COG0586	Pfam SNARE associated Golgi protein
EHW99_RS14650	COG0076	glutamate decarboxylase activity
EHW99_RS14655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHW99_RS14660	COG2207	Transcriptional regulator
EHW99_RS14665	COG0656	L-ascorbic acid biosynthetic process
EHW99_RS14670	COG2132	Multicopper oxidase
EHW99_RS14730	COG3321	synthase
EHW99_RS14730	COG1028	Short-chain dehydrogenase reductase Sdr
EHW99_RS14730	COG0318	PFAM AMP-dependent synthetase and ligase
EHW99_RS14730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EHW99_RS14730	COG0300	oxidoreductase activity
EHW99_RS14745	COG0167	dihydroorotate dehydrogenase activity
EHW99_RS14770	COG3150	esterase
EHW99_RS14775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EHW99_RS14780	COG3151	Protein conserved in bacteria
EHW99_RS14785	COG0494	nUDIX hydrolase
EHW99_RS14790	COG1538	Outer membrane efflux protein
EHW99_RS14795	COG5463	Belongs to the UPF0441 family
EHW99_RS14800	COG0754	glutathionylspermidine amidase activity
EHW99_RS14805	COG3384	dioxygenase
EHW99_RS14810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHW99_RS14820	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EHW99_RS14820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EHW99_RS14830	COG3025	triphosphatase activity
EHW99_RS14835	COG4991	sh3 domain protein
EHW99_RS14840	COG0617	tRNA 3'-terminal CCA addition
EHW99_RS14845	COG1968	undecaprenyl-diphosphatase activity
EHW99_RS14850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EHW99_RS14855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EHW99_RS14860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EHW99_RS14865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EHW99_RS14870	COG0358	DNA primase activity
EHW99_RS14880	COG3663	DNA glycosylase
EHW99_RS14895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EHW99_RS14900	COG3423	Transcriptional regulator
EHW99_RS14910	COG1464	Belongs to the NlpA lipoprotein family
EHW99_RS14915	COG3012	SEC-C Motif Domain Protein
EHW99_RS14915	COG3318	Belongs to the UPF0149 family
EHW99_RS14920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EHW99_RS14960	COG2003	Belongs to the UPF0758 family
EHW99_RS15010	COG1715	Restriction endonuclease
EHW99_RS15030	COG0582	viral genome integration into host DNA
EHW99_RS15045	COG0433	COG0433 Predicted ATPase
EHW99_RS15050	COG2733	membrane
EHW99_RS15055	COG0795	lipopolysaccharide-transporting ATPase activity
EHW99_RS15060	COG0795	lipopolysaccharide-transporting ATPase activity
EHW99_RS15065	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHW99_RS15070	COG2927	DNA polymerase III (CHI subunit)
EHW99_RS15075	COG0525	valine-tRNA ligase activity
EHW99_RS15085	COG2271	Major facilitator Superfamily
EHW99_RS15100	COG0456	acetyltransferase
EHW99_RS15105	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
EHW99_RS15110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EHW99_RS15120	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EHW99_RS15130	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EHW99_RS15135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHW99_RS15145	COG0602	queuosine metabolic process
EHW99_RS15150	COG3766	membrane
EHW99_RS15155	COG2827	Endonuclease containing a URI domain
EHW99_RS15160	COG3153	acetyltransferase
EHW99_RS15165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW99_RS15170	COG0513	Belongs to the DEAD box helicase family
EHW99_RS15185	COG1185	polyribonucleotide nucleotidyltransferase activity
EHW99_RS15190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EHW99_RS15195	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EHW99_RS15200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EHW99_RS15210	COG0195	Participates in both transcription termination and antitermination
EHW99_RS15215	COG0779	Required for maturation of 30S ribosomal subunits
EHW99_RS15230	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EHW99_RS15235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHW99_RS15240	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EHW99_RS15250	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EHW99_RS15255	COG1534	Rna-binding protein
EHW99_RS15265	COG2027	D-alanyl-D-alanine carboxypeptidase
EHW99_RS15270	COG0745	RESPONSE REGULATOR receiver
EHW99_RS15275	COG0642	Histidine kinase
EHW99_RS15280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EHW99_RS15290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EHW99_RS15295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EHW99_RS15300	COG0142	geranyltranstransferase activity
EHW99_RS15305	COG3423	Transcriptional regulator
EHW99_RS15310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EHW99_RS15315	COG5007	Belongs to the BolA IbaG family
EHW99_RS15320	COG3113	response to antibiotic
EHW99_RS15325	COG2854	intermembrane phospholipid transfer
EHW99_RS15330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHW99_RS15335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHW99_RS15340	COG1127	ABC transporter
EHW99_RS15345	COG0530	calcium, potassium:sodium antiporter activity
EHW99_RS15355	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EHW99_RS15360	COG3117	lipopolysaccharide transmembrane transporter activity
EHW99_RS15365	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EHW99_RS15370	COG1137	ATPase activity
EHW99_RS15375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EHW99_RS15390	COG1660	Displays ATPase and GTPase activities
EHW99_RS15395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW99_RS15405	COG0784	Response regulator, receiver
EHW99_RS15405	COG5002	protein histidine kinase activity
EHW99_RS15405	COG2198	Histidine kinase
EHW99_RS15410	COG0070	glutamate synthase
EHW99_RS15410	COG0067	glutamate synthase
EHW99_RS15410	COG0069	glutamate synthase activity
EHW99_RS15415	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EHW99_RS15420	COG2969	positive regulation of protein catabolic process
EHW99_RS15425	COG0625	glutathione transferase activity
EHW99_RS15430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EHW99_RS15435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EHW99_RS15440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EHW99_RS15445	COG3105	Protein conserved in bacteria
EHW99_RS15450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHW99_RS15455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHW99_RS15460	COG0039	L-malate dehydrogenase activity
EHW99_RS15465	COG1438	arginine binding
EHW99_RS15480	COG1289	transmembrane transporter activity
EHW99_RS15485	COG1566	PFAM secretion protein HlyD family protein
EHW99_RS15495	COG0583	DNA-binding transcription factor activity
EHW99_RS15500	COG0312	modulator of DNA gyrase
EHW99_RS15505	COG3164	Protein of unknown function
EHW99_RS15510	COG1530	ribonuclease E activity
EHW99_RS15520	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EHW99_RS15525	COG1792	Involved in formation and maintenance of cell shape
EHW99_RS15530	COG1077	Cell shape determining protein MreB Mrl
EHW99_RS15535	COG2199	diguanylate cyclase activity
EHW99_RS15535	COG2200	EAL domain
EHW99_RS15540	COG0604	alcohol dehydrogenase
EHW99_RS15545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EHW99_RS15555	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EHW99_RS15560	COG0511	ligase activity, forming carbon-carbon bonds
EHW99_RS15565	COG0439	Biotin carboxylase
EHW99_RS15570	COG3924	membrane
EHW99_RS15575	COG4145	pantothenate transmembrane transporter activity
EHW99_RS15580	COG2264	protein methyltransferase activity
EHW99_RS15600	COG1560	Kdo2-lipid A biosynthetic process
EHW99_RS15605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW99_RS15610	COG4597	amino acid ABC transporter
EHW99_RS15615	COG0765	amino acid transport
EHW99_RS15620	COG1126	abc transporter atp-binding protein
EHW99_RS15655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EHW99_RS15665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHW99_RS15675	COG0551	DNA topoisomerase type I activity
EHW99_RS15680	COG2922	Belongs to the Smg family
EHW99_RS15685	COG0758	DNA mediated transformation
EHW99_RS15690	COG0242	peptide deformylase activity
EHW99_RS15695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHW99_RS15700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHW99_RS15700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EHW99_RS15710	COG1970	mechanosensitive ion channel activity
EHW99_RS15720	COG3036	rescue of stalled ribosome
EHW99_RS15725	COG0789	Transcriptional regulator
EHW99_RS15735	COG0203	ribosomal protein L17
EHW99_RS15740	COG0202	RNA polymerase activity
EHW99_RS15745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EHW99_RS15750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EHW99_RS15755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EHW99_RS15760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EHW99_RS15765	COG0201	protein transport
EHW99_RS15770	COG0200	Binds to the 23S rRNA
EHW99_RS15775	COG1841	ribosomal large subunit assembly
EHW99_RS15785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EHW99_RS15790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EHW99_RS15795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EHW99_RS15800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EHW99_RS15805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EHW99_RS15810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EHW99_RS15815	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EHW99_RS15820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EHW99_RS15825	COG0255	Belongs to the universal ribosomal protein uL29 family
EHW99_RS15830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EHW99_RS15840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EHW99_RS15845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EHW99_RS15850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EHW99_RS15855	COG0089	rRNA binding
EHW99_RS15860	COG0088	Forms part of the polypeptide exit tunnel
EHW99_RS15865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EHW99_RS15870	COG0051	transcription antitermination factor activity, RNA binding
EHW99_RS15880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHW99_RS15885	COG0049	tRNA binding
EHW99_RS15890	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EHW99_RS15895	COG2168	tRNA wobble position uridine thiolation
EHW99_RS15900	COG2923	Belongs to the DsrF TusC family
EHW99_RS15905	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EHW99_RS15910	COG2964	Protein conserved in bacteria
EHW99_RS15915	COG0545	Peptidyl-prolyl cis-trans isomerase
EHW99_RS15920	COG2900	Belongs to the SlyX family
EHW99_RS15925	COG1047	Peptidyl-prolyl cis-trans
EHW99_RS15930	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EHW99_RS15935	COG0475	glutathione-regulated potassium exporter activity
EHW99_RS15935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EHW99_RS15940	COG2249	NAD(P)H dehydrogenase (quinone) activity
EHW99_RS15945	COG0488	(ABC) transporter
EHW99_RS15955	COG2175	clavaminate synthase activity
EHW99_RS15960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW99_RS15970	COG4521	taurine ABC transporter
EHW99_RS15980	COG0429	hydrolase of the alpha beta-hydrolase fold
EHW99_RS15985	COG3089	Belongs to the UPF0270 family
EHW99_RS15990	COG3954	Phosphoribulokinase
EHW99_RS15995	COG1765	OsmC-like protein
EHW99_RS16005	COG1289	transmembrane transporter activity
EHW99_RS16010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EHW99_RS16025	COG0738	Major facilitator superfamily
EHW99_RS16030	COG0402	S-adenosylhomocysteine deaminase activity
EHW99_RS16035	COG0402	S-adenosylhomocysteine deaminase activity
EHW99_RS16060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EHW99_RS16070	COG3266	domain, Protein
EHW99_RS16075	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EHW99_RS16080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHW99_RS16085	COG4796	Type ii and iii secretion system protein
EHW99_RS16110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EHW99_RS16115	COG0494	nUDIX hydrolase
EHW99_RS16125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EHW99_RS16130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EHW99_RS16135	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EHW99_RS16145	COG0745	RESPONSE REGULATOR receiver
EHW99_RS16150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHW99_RS16155	COG2183	response to ionizing radiation
EHW99_RS16160	COG0366	Alpha amylase catalytic
EHW99_RS16170	COG1040	competence protein
EHW99_RS16175	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EHW99_RS16175	COG0316	Belongs to the HesB IscA family
EHW99_RS16180	COG1640	4-alpha-glucanotransferase
EHW99_RS16185	COG0058	SHG alpha-glucan phosphorylase activity
EHW99_RS16190	COG1349	DNA-binding transcription factor activity
EHW99_RS16195	COG0705	Rhomboid family
EHW99_RS16200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHW99_RS16205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EHW99_RS16220	COG0058	SHG alpha-glucan phosphorylase activity
EHW99_RS16225	COG0297	glycogen (starch) synthase activity
EHW99_RS16235	COG1523	belongs to the glycosyl hydrolase 13 family
EHW99_RS16250	COG2610	gluconate transmembrane transporter activity
EHW99_RS16255	COG3265	gluconokinase activity
EHW99_RS16260	COG1609	Transcriptional regulator
EHW99_RS16265	COG1741	Belongs to the pirin family
EHW99_RS16270	COG1247	-acetyltransferase
EHW99_RS16275	COG0405	Gamma-glutamyltransferase
EHW99_RS16285	COG0584	glycerophosphoryl diester phosphodiesterase
EHW99_RS16295	COG0395	ABC-type sugar transport system, permease component
EHW99_RS16305	COG1653	transport
EHW99_RS16315	COG0411	ABC transporter
EHW99_RS16320	COG4177	L-phenylalanine transmembrane transporter activity
EHW99_RS16335	COG0456	acetyltransferase
EHW99_RS16345	COG2177	Part of the ABC transporter FtsEX involved in
EHW99_RS16350	COG2884	Cell division ATP-binding protein ftsE
EHW99_RS16355	COG0552	protein localization to endoplasmic reticulum
EHW99_RS16360	COG0742	ribosomal rna small subunit methyltransferase
EHW99_RS16365	COG3776	membrane
EHW99_RS16370	COG3714	YhhN family
EHW99_RS16380	COG0425	Belongs to the sulfur carrier protein TusA family
EHW99_RS16385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EHW99_RS16395	COG1082	Xylose isomerase domain protein TIM barrel
EHW99_RS16400	COG0673	inositol 2-dehydrogenase activity
EHW99_RS16405	COG3962	Belongs to the TPP enzyme family
EHW99_RS16410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW99_RS16420	COG3718	enzyme involved in inositol metabolism
EHW99_RS16430	COG0628	permease
EHW99_RS16435	COG2200	EAL domain
EHW99_RS16445	COG1064	alcohol dehydrogenase
EHW99_RS16480	COG2081	HI0933 family
EHW99_RS16485	COG0306	phosphate transporter
EHW99_RS16495	COG0589	response to stress
EHW99_RS16500	COG0742	ribosomal rna small subunit methyltransferase
EHW99_RS16525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EHW99_RS16530	COG1234	tRNA 3'-trailer cleavage
EHW99_RS16535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHW99_RS16545	COG3038	cytochrome b561
EHW99_RS16570	COG2862	Uncharacterized protein family, UPF0114
EHW99_RS16595	COG3708	Transcriptional regulator
EHW99_RS16595	COG2207	Transcriptional regulator
EHW99_RS16615	COG1132	(ABC) transporter
EHW99_RS16620	COG0840	transmembrane signaling receptor activity
EHW99_RS16625	COG3386	PFAM SMP-30 Gluconolaconase
EHW99_RS16635	COG2205	protein histidine kinase activity
EHW99_RS16640	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EHW99_RS16645	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EHW99_RS16650	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EHW99_RS16700	COG0673	inositol 2-dehydrogenase activity
EHW99_RS16715	COG0673	inositol 2-dehydrogenase activity
EHW99_RS16720	COG1971	Probably functions as a manganese efflux pump
EHW99_RS16745	COG0477	Major facilitator Superfamily
EHW99_RS16750	COG2982	Protein involved in outer membrane biogenesis
EHW99_RS16755	COG2200	EAL domain
EHW99_RS16770	COG1301	dicarboxylic acid transport
EHW99_RS16775	COG2199	diguanylate cyclase activity
EHW99_RS16775	COG2200	EAL domain
EHW99_RS16785	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EHW99_RS16795	COG0457	Tetratricopeptide repeat
EHW99_RS16800	COG1215	transferase activity, transferring glycosyl groups
EHW99_RS16805	COG1215	transferase activity, transferring glycosyl groups
EHW99_RS16810	COG2894	cell division
EHW99_RS16820	COG4608	Belongs to the ABC transporter superfamily
EHW99_RS16825	COG0444	Belongs to the ABC transporter superfamily
EHW99_RS16830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW99_RS16835	COG0601	transmembrane transport
EHW99_RS16840	COG0747	negative chemotaxis
EHW99_RS16855	COG1764	response to oxidative stress
EHW99_RS16860	COG1846	Transcriptional regulator
EHW99_RS16900	COG0246	Mannitol dehydrogenase
EHW99_RS16910	COG3274	enterobacterial common antigen metabolic process
EHW99_RS16915	COG0752	glycyl-tRNA synthetase alpha subunit
EHW99_RS16920	COG0751	glycine-tRNA ligase activity
EHW99_RS16925	COG1064	alcohol dehydrogenase
EHW99_RS16930	COG2944	sequence-specific DNA binding
EHW99_RS16940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW99_RS16940	COG2213	PTS system mannitol-specific
EHW99_RS16945	COG0246	Mannitol dehydrogenase
EHW99_RS16950	COG3722	fumarate hydratase activity
EHW99_RS16970	COG0745	RESPONSE REGULATOR receiver
EHW99_RS16980	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW99_RS16985	COG1129	ABC transporter
EHW99_RS16990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EHW99_RS16995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHW99_RS17000	COG1349	DNA-binding transcription factor activity
EHW99_RS17010	COG3058	Necessary for formate dehydrogenase activity
EHW99_RS17015	COG0625	glutathione transferase activity
EHW99_RS17020	COG2818	Glycosylase
EHW99_RS17025	COG2885	chlorophyll binding
EHW99_RS17030	COG1609	Transcriptional regulator
EHW99_RS17050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW99_RS17055	COG2271	Major facilitator Superfamily
EHW99_RS17060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EHW99_RS17075	COG3977	Valine--pyruvate aminotransferase
EHW99_RS17085	COG5645	(Lipo)protein
EHW99_RS17090	COG0823	Involved in the tonB-independent uptake of proteins
EHW99_RS17095	COG0561	phosphatase activity
EHW99_RS17100	COG0187	DNA topoisomerase II activity
EHW99_RS17105	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EHW99_RS17110	COG0592	DNA-directed DNA polymerase activity
EHW99_RS17115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EHW99_RS17120	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EHW99_RS17125	COG0594	ribonuclease P activity
EHW99_RS17135	COG0706	membrane insertase activity
EHW99_RS17140	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EHW99_RS17145	COG2091	lysine biosynthetic process via aminoadipic acid
EHW99_RS17150	COG2252	PERMEase
EHW99_RS17160	COG2814	Major facilitator Superfamily
EHW99_RS17165	COG0704	Plays a role in the regulation of phosphate uptake
EHW99_RS17170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHW99_RS17175	COG0581	inorganic phosphate transmembrane transporter activity
EHW99_RS17180	COG0573	inorganic phosphate transmembrane transporter activity
EHW99_RS17185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EHW99_RS17205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EHW99_RS17210	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EHW99_RS17215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EHW99_RS17220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EHW99_RS17225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EHW99_RS17230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EHW99_RS17235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EHW99_RS17240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EHW99_RS17250	COG0356	it plays a direct role in the translocation of protons across the membrane
EHW99_RS17255	COG3312	ion transport
EHW99_RS17260	COG0357	Ribosomal RNA small subunit methyltransferase G
EHW99_RS17285	COG0583	DNA-binding transcription factor activity
EHW99_RS17290	COG1012	belongs to the aldehyde dehydrogenase family
EHW99_RS17300	COG4628	conserved protein (DUF2132)
EHW99_RS17365	COG1192	Involved in chromosome partitioning
EHW99_RS17375	COG0500	methyltransferase
EHW99_RS17380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHW99_RS17400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine