locus-tag class description HU055_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HU055_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HU055_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HU055_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HU055_RS00025 ENOG410667J hydrolase HU055_RS00030 ENOG4105D99 atp gtp-binding protein HU055_RS00035 ENOG4105R2A (LipO)protein HU055_RS00040 ENOG4108ZNX Heat shock protein HU055_RS00045 ENOG4105JKW Valine--pyruvate aminotransferase HU055_RS00060 ENOG4105C5I Dehydrogenase HU055_RS00065 ENOG4108I5G Major Facilitator superfamily HU055_RS00070 ENOG4105D7K pfkb domain protein HU055_RS00090 ENOG4108M60 Transcriptional regulator HU055_RS00095 ENOG4108ZG0 Ompa motb domain protein HU055_RS00100 ENOG4108R3E Dna-3-methyladenine glycosylase i HU055_RS00105 ENOG4108U78 Glutathione S-transferase HU055_RS00110 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HU055_RS00120 ENOG4105E98 transcriptional regulator DeoR family HU055_RS00130 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HU055_RS00135 ENOG4105C2J ABC transporter HU055_RS00140 ENOG4105CNN ABC, transporter HU055_RS00150 ENOG4108KXV response regulator HU055_RS00160 ENOG4108Q9V regulatoR HU055_RS00165 ENOG4108YYI Protein of unknown function (DUF2810) HU055_RS00170 ENOG4105E61 Mannitol repressor protein HU055_RS00175 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HU055_RS00180 ENOG4105CTS PTS system mannitol-specific HU055_RS00185 ENOG4106JH6 (LipO)protein HU055_RS00190 ENOG4105MVF Transcriptional regulator HU055_RS00195 ENOG4105DQ4 alcohol dehydrogenase HU055_RS00200 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HU055_RS00205 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HU055_RS00210 ENOG4105MEV Acyl-transferase HU055_RS00220 ENOG4105DEI Mannitol dehydrogenase HU055_RS00260 ENOG4105K56 Transcriptional regulator HU055_RS00265 ENOG4108ZHJ Organic hydroperoxide resistance protein HU055_RS00270 ENOG4105DIJ Phosphoethanolamine transferase HU055_RS00280 ENOG4105DEF Extracellular solute-binding protein, family 5 HU055_RS00285 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HU055_RS00290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HU055_RS00295 ENOG4105C3U ABC transporter HU055_RS00300 ENOG4108JQ7 (ABC) transporter HU055_RS00310 ENOG4107U53 septum site-determining protein minD HU055_RS00315 ENOG4107QZ7 Cellulose synthase catalytic subunit HU055_RS00320 ENOG4107EEX Cellulose synthase regulator protein HU055_RS00325 ENOG4105EJG cellulose synthase HU055_RS00335 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HU055_RS00340 ENOG4105U74 cellulose biosynthesis protein BcsE HU055_RS00345 ENOG4105BZU Histidine kinase HU055_RS00350 ENOG4105CK2 sodium dicarboxylate symporter HU055_RS00355 ENOG4105CS0 peptidase HU055_RS00365 ENOG4105CMB EAL domain-containing protein HU055_RS00370 ENOG41066T0 asmA family HU055_RS00375 ENOG4105CSH Transporter HU055_RS00385 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HU055_RS00390 ENOG4105WQ6 Membrane HU055_RS00400 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) HU055_RS00405 ENOG4105CIB oxidoreductase Domain protein HU055_RS00420 ENOG4105CIB oxidoreductase Domain protein HU055_RS00435 ENOG4108JJ6 Type I secretion system ATPase HU055_RS00440 ENOG4107QZV Type I secretion membrane fusion protein HU055_RS00445 ENOG4105DFG type I secretion outer membrane protein HU055_RS00470 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HU055_RS00475 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HU055_RS00480 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HU055_RS00485 ENOG4105C08 Histidine kinase HU055_RS00500 ENOG4105C8Q Methyl-accepting chemotaxis HU055_RS00505 ENOG4105BZ1 (ABC) transporter HU055_RS00525 ENOG4105UEI Transcriptional Regulator AraC Family HU055_RS00550 ENOG4108TEB UPF0114 protein HU055_RS00575 ENOG4105CPW cytochrome b561 HU055_RS00585 ENOG4105DC8 reductase HU055_RS00590 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HU055_RS00595 ENOG4105D6S protein involved in catabolism of external DNA HU055_RS00615 ENOG4105DGW oligopeptidase A HU055_RS00620 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HU055_RS00630 ENOG4108V6B universal stress protein B HU055_RS00635 ENOG4105CJ3 phosphate transporter HU055_RS00640 ENOG4105CBX hi0933 family HU055_RS00675 ENOG4105DQ4 alcohol dehydrogenase HU055_RS00680 ENOG4105CSH Transporter HU055_RS00685 ENOG4107XTP (EAL) domain protein HU055_RS00690 ENOG4105DSF transport protein HU055_RS00695 ENOG4105C26 Dehydrogenase HU055_RS00700 ENOG4105DH8 myo-inositol catabolism HU055_RS00710 ENOG4105D7K pfkb domain protein HU055_RS00715 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HU055_RS00720 ENOG4107RJ5 oxidoreductase HU055_RS00725 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HU055_RS00730 ENOG4108W1V Lipoprotein HU055_RS00735 ENOG4105EX9 Membrane HU055_RS00740 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HU055_RS00750 ENOG4107FS9 Membrane HU055_RS00755 ENOG4105MG3 Membrane HU055_RS00760 ENOG4106H78 methyltransferase HU055_RS00765 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HU055_RS00770 ENOG4105CAK Cell division ATP-binding protein ftsE HU055_RS00775 ENOG4105CRP Part of the ABC transporter FtsEX involved in HU055_RS00785 ENOG4105U59 -acetyltransferase HU055_RS00790 ENOG4105CP9 extracellular ligand-binding receptor HU055_RS00795 ENOG4105C32 Amino acid ABC transporter (Permease) HU055_RS00800 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HU055_RS00805 ENOG4105C0Z ABC transporter HU055_RS00810 ENOG4108IV0 ABC, transporter HU055_RS00815 ENOG4105BZ7 extracellular solute-binding protein family 1 HU055_RS00825 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HU055_RS00835 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HU055_RS00845 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HU055_RS00850 ENOG4105WCN acetyltransferase HU055_RS00855 ENOG4105C2I pirin domain protein HU055_RS00860 ENOG4105DIQ Transcriptional regulator HU055_RS00865 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HU055_RS00870 ENOG4105C6Z Gluconate HU055_RS00875 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HU055_RS00885 ENOG4108IUM Glycogen debranching enzyme HU055_RS00895 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HU055_RS00900 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HU055_RS00915 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HU055_RS00920 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HU055_RS00925 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HU055_RS00930 ENOG4105E98 transcriptional regulator DeoR family HU055_RS00935 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HU055_RS00940 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HU055_RS00945 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HU055_RS00950 ENOG4105MJ2 Competence protein HU055_RS00960 ENOG4107QW3 Sucrose phosphorylase HU055_RS00965 ENOG4105BZM domain protein HU055_RS00970 ENOG4108RRZ Transcription elongation factor GreB HU055_RS00980 ENOG4105E0F Histidine kinase HU055_RS00985 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HU055_RS00990 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HU055_RS00995 ENOG4105VEJ Heat shock protein HU055_RS01000 ENOG4105DQY intracellular growth attenuator HU055_RS01005 ENOG4107RK2 ADP-ribose diphosphatase NudE HU055_RS01010 ENOG4108JQC penicillin-binding protein 1A HU055_RS01035 ENOG4105E4G Type IV pilus HU055_RS01040 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HU055_RS01045 ENOG4105D49 3-dehydroquinate synthase HU055_RS01050 ENOG4105EGB membrane protein DamX HU055_RS01060 ENOG4105DJV ribulose-phosphate 3-epimerase HU055_RS01070 ENOG4105C31 Tryptophanyl-tRNA synthetase HU055_RS01085 ENOG4105DZC cytosine deaminase HU055_RS01090 ENOG4105DZC cytosine deaminase HU055_RS01095 ENOG4106DTQ Protein TsgA homolog HU055_RS01100 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HU055_RS01110 ENOG4105C8Y Acetylornithine aminotransferase HU055_RS01115 ENOG410613R integral membrane protein, YccS YhfK family HU055_RS01120 ENOG4107RYR Transcriptional regulator, Crp Fnr family HU055_RS01125 ENOG4108UKZ OsmC family HU055_RS01130 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HU055_RS01135 ENOG4105YP7 UPF0270 protein HU055_RS01140 ENOG4105DNZ Alpha Beta Hydrolase HU055_RS01150 ENOG4106FTQ Taurine ABC transporter, periplasmic HU055_RS01160 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HU055_RS01165 ENOG4105E2B Taurine dioxygenase HU055_RS01175 ENOG4105C5H ABC transporter HU055_RS01180 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HU055_RS01190 ENOG4105VKU nucleicacid-binding protein HU055_RS01195 ENOG4108YZY peptidylprolyl cis-trans isomerase HU055_RS01200 ENOG4105VRX Protein slyX homolog HU055_RS01205 ENOG4108V1T peptidylprolyl cis-trans isomerase HU055_RS01210 ENOG4105WWK YheO domain protein HU055_RS01215 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HU055_RS01220 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HU055_RS01225 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HU055_RS01230 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HU055_RS01235 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HU055_RS01240 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HU055_RS01245 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HU055_RS01255 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HU055_RS01260 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HU055_RS01265 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HU055_RS01270 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HU055_RS01275 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HU055_RS01280 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HU055_RS01285 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HU055_RS01290 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HU055_RS01300 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HU055_RS01305 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HU055_RS01310 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HU055_RS01315 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HU055_RS01320 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HU055_RS01325 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HU055_RS01330 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HU055_RS01335 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HU055_RS01345 ENOG4105VPB 50S ribosomal protein L30 HU055_RS01350 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HU055_RS01355 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HU055_RS01360 ENOG41067V7 50S ribosomal protein L36 HU055_RS01365 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HU055_RS01370 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HU055_RS01375 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HU055_RS01380 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HU055_RS01385 ENOG4108ZT0 50S ribosomal protein l17 HU055_RS01390 ENOG4105VTS DnaJ-like, subfamily C HU055_RS01395 ENOG4105W1Y Transcriptional regulator HU055_RS01400 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HU055_RS01410 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HU055_RS01415 ENOG4105C1A potassium transporter peripheral membrane HU055_RS01420 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HU055_RS01425 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HU055_RS01430 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HU055_RS01435 ENOG4105C79 DNA protecting protein DprA HU055_RS01440 ENOG4108RPN Protein smg homolog HU055_RS01445 ENOG4108WI1 Dna topoisomerase HU055_RS01455 ENOG4105E2X shikimate dehydrogenase HU055_RS01465 ENOG4108Z0R Transferase HU055_RS01500 ENOG4105CDA abc transporter atp-binding protein HU055_RS01505 ENOG4105DRP amino acid AbC transporter HU055_RS01510 ENOG4105EZ7 amino acid ABC transporter HU055_RS01520 ENOG4105D1S lipid A biosynthesis HU055_RS01535 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HU055_RS01540 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HU055_RS01545 ENOG4108IA2 Sodium pantothenate symporter HU055_RS01550 ENOG4105RG0 Membrane HU055_RS01555 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HU055_RS01560 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HU055_RS01565 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HU055_RS01570 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HU055_RS01575 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HU055_RS01580 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HU055_RS01585 ENOG41062P1 Diguanylate cyclase phosphodiesterase HU055_RS01595 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HU055_RS01600 ENOG4105VQ7 Rod shape-determining protein MreD HU055_RS01605 ENOG4108Z03 MAF-like protein HU055_RS01610 ENOG4105C03 ribonuclease HU055_RS01620 ENOG4105D1U peptidase U62 modulator of DNA gyrase HU055_RS01625 ENOG4105CR8 Transcriptional regulator HU055_RS01630 ENOG4105ZQC membrane protein AaeX HU055_RS01635 ENOG4105Y49 secretion protein, HlyD family HU055_RS01640 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HU055_RS01645 ENOG4105RID UPF0379 protein yhcN HU055_RS01650 ENOG4105RID UPF0379 protein yhcN HU055_RS01655 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HU055_RS01660 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HU055_RS01665 ENOG4105C0H protease HU055_RS01670 ENOG4105C0H protease HU055_RS01675 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HU055_RS01680 ENOG4105D6Z AFG1 family ATPase HU055_RS01685 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HU055_RS01690 ENOG4108UJD 30S ribosomal protein S9 HU055_RS01695 ENOG4107MKT Stringent starvation protein a HU055_RS01700 ENOG4105KB2 stringent starvation protein b HU055_RS01705 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HU055_RS01710 ENOG4105CBC glutamate synthase HU055_RS01715 ENOG4105BZU Histidine kinase HU055_RS01720 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HU055_RS01725 ENOG41080Z8 PHOSPHOCARRIER protein HU055_RS01730 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HU055_RS01735 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HU055_RS01740 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HU055_RS01745 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HU055_RS01750 ENOG4108IUZ ABC transporter HU055_RS01755 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HU055_RS01760 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HU055_RS01765 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HU055_RS01770 ENOG4105C2X Arabinose 5-phosphate isomerase HU055_RS01775 ENOG4105FEU K -dependent Na -Ca exchanger HU055_RS01780 ENOG4105DHJ ABC, transporter HU055_RS01785 ENOG4105CY3 ABC transporter, permease HU055_RS01790 ENOG4107PE3 Mammalian cell entry related domain protein HU055_RS01795 ENOG4105E3I toluene tolerance HU055_RS01800 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HU055_RS01805 ENOG4105VFK BolA family HU055_RS01810 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HU055_RS01815 ENOG4105HVQ Regulatory factor of maltose metabolism HU055_RS01820 ENOG4105EAH synthase HU055_RS01825 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HU055_RS01830 ENOG4105K46 50S ribosomal protein l27 HU055_RS01840 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HU055_RS01855 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HU055_RS01860 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HU055_RS01865 ENOG4105HBR Rna-binding protein HU055_RS01870 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) HU055_RS01875 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HU055_RS01880 ENOG4105EEI dihydropteroate synthase HU055_RS01885 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HU055_RS01890 ENOG4105NTZ Preprotein translocase subunit SecG HU055_RS01905 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HU055_RS01910 ENOG4105CHV Transcription elongation factor NusA HU055_RS01915 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HU055_RS01920 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HU055_RS01925 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HU055_RS01930 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HU055_RS01935 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HU055_RS01950 ENOG4105C1J atp-dependent rna helicase HU055_RS01955 ENOG4105DEN Luciferase family HU055_RS01960 ENOG4108YYD acetyltransferase HU055_RS01965 ENOG41082IR Excinuclease ABC C subunit domain protein HU055_RS01970 ENOG4105Z6B inner membrane protein yjfl HU055_RS01975 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HU055_RS01985 ENOG4105C0D helicase HU055_RS01990 ENOG4105E2D ec 3.2.1.52 HU055_RS01995 ENOG4105KME endoribonuclease L-psp HU055_RS02000 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HU055_RS02005 ENOG4105CXT aspartate transcarbamylase HU055_RS02010 ENOG4105DBV ornithine carbamoyltransferase HU055_RS02015 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HU055_RS02020 ENOG4108MJ3 acetyltransferase HU055_RS02035 ENOG4105CXY transporter HU055_RS02045 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HU055_RS02050 ENOG4105MYG DNA polymerase iii, chi subunit HU055_RS02055 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HU055_RS02060 ENOG4108M8S permease YjgP YjgQ family protein HU055_RS02065 ENOG4108K5H permease YjgP YjgQ family protein HU055_RS02070 ENOG4106BRA Membrane HU055_RS02075 ENOG4105D7A ATP-binding protein HU055_RS02080 ENOG4105RI1 glycoprotein receptor HU055_RS02110 ENOG4106H3A restriction HU055_RS02160 ENOG4108XS9 dna repair protein HU055_RS02165 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HU055_RS02170 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HU055_RS02200 ENOG4108IJ6 ABC transporter HU055_RS02205 ENOG4106RHG Yeca family HU055_RS02210 ENOG4105D01 (LipO)protein HU055_RS02220 ENOG4105HVQ Regulatory factor of maltose metabolism HU055_RS02225 ENOG4107R6D beta-lactam binding protein AmpH HU055_RS02240 ENOG4108VCA G U mismatch-specific DNA glycosylase HU055_RS02245 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HU055_RS02250 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HU055_RS02260 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HU055_RS02265 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HU055_RS02270 ENOG4107ZVW dihydroneopterin aldolase HU055_RS02275 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HU055_RS02280 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HU055_RS02285 ENOG4106MWK domain protein HU055_RS02290 ENOG4105I7R Adenylate cyclase HU055_RS02295 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HU055_RS02300 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HU055_RS02305 ENOG4105W0Z cytoplasmic protein HU055_RS02310 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HU055_RS02315 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HU055_RS02320 ENOG4106032 Glutathionylspermidine synthase HU055_RS02325 ENOG4105F1G UPF0441 protein HU055_RS02330 ENOG4105DFG type I secretion outer membrane protein HU055_RS02335 ENOG41087AY ADP-Ribose pyrophosphatase HU055_RS02340 ENOG4108SX3 cytoplasmic protein HU055_RS02345 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HU055_RS02350 ENOG4105IPS esterase HU055_RS02355 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HU055_RS02375 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HU055_RS02390 ENOG4105C0W non-ribosomal peptide synthetase HU055_RS02435 ENOG4105F87 Dehydratase HU055_RS02440 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HU055_RS02445 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HU055_RS02450 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HU055_RS02455 ENOG4105CV8 reductase HU055_RS02460 ENOG4105CF7 AraC family transcriptional regulator HU055_RS02465 ENOG4108JPW Aminotransferase HU055_RS02470 ENOG4105DY8 decarboxylase HU055_RS02475 ENOG4108K81 inner membrane protein YghB HU055_RS02480 ENOG4105C28 cystathionine HU055_RS02485 ENOG4105CWK Biopolymer transport protein, ExbB HU055_RS02490 ENOG4108ZZF transport protein (ExbD) HU055_RS02495 ENOG4105CSH Transporter HU055_RS02500 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HU055_RS02530 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HU055_RS02535 ENOG4105GSJ Inner membrane protein ylaC HU055_RS02555 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HU055_RS02565 ENOG41090A1 ferritin HU055_RS02575 ENOG4105RXK Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HU055_RS02590 ENOG4105CS2 ec 3.2.1.21 HU055_RS02595 ENOG4105CS2 ec 3.2.1.21 HU055_RS02600 ENOG4105VCP PTS System HU055_RS02605 ENOG4105CK1 PTS System HU055_RS02615 ENOG4105DDV Transcriptional regulator (LacI family HU055_RS02640 ENOG4105F7P transcriptional regulator AsnC family HU055_RS02660 ENOG4108HRK Histidine kinase HU055_RS02665 ENOG4108NEV two component transcriptional regulator, LytTR family HU055_RS02670 ENOG4105VCD cytoplasmic protein HU055_RS02675 ENOG4105D22 carbon starvation protein HU055_RS02685 ENOG41066YJ Beta-lactamase HU055_RS02690 ENOG4108WN0 inhibitor of vertebrate lysozyme HU055_RS02710 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase HU055_RS02715 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase HU055_RS02745 ENOG4108HHI Type III secretion system protein HU055_RS02775 ENOG4108HR8 type iii secretion HU055_RS02785 ENOG4105I6B RNA polymerase HU055_RS02795 ENOG4105WH1 Two component transcriptional regulator luxr family HU055_RS02825 ENOG4107Y59 type iii secretion HU055_RS02885 ENOG4108E16 pectate lyase HU055_RS02900 ENOG4106P55 Transcriptional regulator HU055_RS02905 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HU055_RS02920 ENOG4105NVB glycoside hydrolase, family 19 HU055_RS02985 ENOG4105CXN decarboxylase HU055_RS02995 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HU055_RS03000 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HU055_RS03005 ENOG4105CEN a g-specific adenine glycosylase HU055_RS03015 ENOG41090ED Protein with unknown function (DUF469) HU055_RS03020 ENOG4105K33 Periplasmic Protein HU055_RS03025 ENOG4105CSA Coproporphyrinogen iii oxidase HU055_RS03030 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HU055_RS03035 ENOG4108VIA integral membrane protein HU055_RS03040 ENOG4105DFA alanine racemase domain protein HU055_RS03045 ENOG4105CZX twitching motility protein HU055_RS03060 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HU055_RS03070 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HU055_RS03075 ENOG4108UJU UPF0301 protein HU055_RS03080 ENOG4105D7Z glutathione synthase HU055_RS03085 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HU055_RS03090 ENOG4105RWS endonuclease I HU055_RS03095 ENOG4105GPY SprT protein HU055_RS03100 ENOG4107QNK )-transporter HU055_RS03105 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HU055_RS03110 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HU055_RS03120 ENOG4105CYW agmatinase HU055_RS03145 ENOG4105C8Q Methyl-accepting chemotaxis HU055_RS03150 ENOG4108K0D peptidase, M48 HU055_RS03155 ENOG4105CV1 Transketolase (EC 2.2.1.1) HU055_RS03160 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HU055_RS03165 ENOG4105BZA Phosphoglycerate kinase HU055_RS03170 ENOG4105D2N Aldolase HU055_RS03175 ENOG4105D64 Mechanosensitive ion channel HU055_RS03190 ENOG4105H3G oxidoreductase HU055_RS03220 ENOG4105MPN Membrane HU055_RS03225 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HU055_RS03230 ENOG4105E66 phosphoriboisomerase A HU055_RS03240 ENOG4108JQ1 Dehydrogenase HU055_RS03245 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HU055_RS03255 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HU055_RS03260 ENOG4105E07 UPF0149 protein HU055_RS03265 ENOG4107RAQ aminopeptidase HU055_RS03270 ENOG4105D0A hydroxylase HU055_RS03275 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HU055_RS03280 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HU055_RS03285 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HU055_RS03290 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HU055_RS03295 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HU055_RS03305 ENOG4108UT2 hemolysin iii HU055_RS03310 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HU055_RS03315 ENOG4105Y75 tpr repeat protein HU055_RS03320 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HU055_RS03325 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HU055_RS03330 ENOG4105DXC membrane HU055_RS03335 ENOG4108NR7 pectate lyase HU055_RS03340 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HU055_RS03345 ENOG4105T95 Thiol disulfide interChange protein HU055_RS03350 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HU055_RS03360 ENOG4105CRK lysyL-tRNA synthetase HU055_RS03370 ENOG4105F27 Major Facilitator HU055_RS03375 ENOG4105RQF LysR family Transcriptional regulator HU055_RS03385 ENOG41060NJ transcriptional regulator HU055_RS03395 ENOG4105H38 Membrane HU055_RS03400 ENOG41067NU HU055_RS03415 ENOG4105CKT filamentous hemagglutinin HU055_RS03430 ENOG41067NU HU055_RS03445 ENOG41067NU HU055_RS03460 ENOG4105CKT filamentous hemagglutinin HU055_RS03465 ENOG4105D5K Hemolysin activator protein HU055_RS03480 ENOG4105BZS acriflavin resistance protein HU055_RS03505 ENOG4105CEY Amp-dependent synthetase and ligase HU055_RS03510 ENOG4107S74 Lysophospholipid transporter LplT HU055_RS03515 ENOG4105CPC Aldo Keto reductase HU055_RS03520 ENOG4105SUV lipoprotein YgdR HU055_RS03525 ENOG4105EE5 Membrane protein terC HU055_RS03530 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) HU055_RS03535 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HU055_RS03540 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HU055_RS03545 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HU055_RS03550 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HU055_RS03555 ENOG4108UQS dipeptidase HU055_RS03565 ENOG4105JCS prepilin peptidase dependent protein HU055_RS03580 ENOG4105DSY exodeoxyribonuclease V, gamma HU055_RS03585 ENOG4107QXK peptidase HU055_RS03595 ENOG4107QYX exodeoxyribonuclease v alpha HU055_RS03605 ENOG4107QZM n-acetylglutamate synthase HU055_RS03610 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HU055_RS03630 ENOG4105CA3 membrane-bound lytic murein transglycosylase HU055_RS03635 ENOG4105CUZ uba thif-type nad fad binding protein HU055_RS03640 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HU055_RS03645 ENOG4105C9B Cysteine desulfurase HU055_RS03650 ENOG4105M5B (LipO)protein HU055_RS03655 ENOG4105ETT transcriptional Regulator, LysR family HU055_RS03660 ENOG4105M08 Membrane HU055_RS03665 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HU055_RS03670 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HU055_RS03675 ENOG4105EWT decarboxylase family HU055_RS03680 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HU055_RS03685 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HU055_RS03690 ENOG4105WP7 tRNA pseudouridine synthase C HU055_RS03695 ENOG4105DR9 pseudouridine synthase HU055_RS03700 ENOG4105QDK Flavodoxin HU055_RS03705 ENOG4105BZW Glycerate kinase HU055_RS03710 ENOG4105BZU Histidine kinase HU055_RS03715 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HU055_RS03720 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HU055_RS03725 ENOG4105DXN mazG family HU055_RS03730 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HU055_RS03735 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HU055_RS03740 ENOG4105EXC Acyl-transferase HU055_RS03745 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HU055_RS03750 ENOG4105EAB amino acid AbC transporter HU055_RS03755 ENOG4105CDA abc transporter atp-binding protein HU055_RS03760 ENOG4105DRP amino acid AbC transporter HU055_RS03770 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HU055_RS03775 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HU055_RS03780 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HU055_RS03785 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HU055_RS03795 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HU055_RS03800 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HU055_RS03805 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HU055_RS03810 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HU055_RS03815 ENOG4105N0Z inner membrane protein ygbE HU055_RS03820 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HU055_RS03825 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HU055_RS03830 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HU055_RS03835 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HU055_RS03840 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HU055_RS03845 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HU055_RS03850 ENOG4108K5P (LipO)protein HU055_RS03855 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HU055_RS03860 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HU055_RS03895 ENOG4106BTR HU055_RS03900 ENOG4105Y7Q type iii secretion HU055_RS03920 ENOG4108N8R Invasion protein HU055_RS03925 ENOG4108HR8 type iii secretion HU055_RS03935 ENOG4108JIR Flagellum-specific ATP synthase HU055_RS03955 ENOG41075IY surface presentation of antigens protein SpaP HU055_RS03960 ENOG4105U07 type iii secretion HU055_RS03965 ENOG4108TN6 type iii secretion HU055_RS03980 ENOG4106H1J Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE HU055_RS04000 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HU055_RS04015 ENOG4108Z33 Thiol disulfide Interchange Protein HU055_RS04020 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HU055_RS04025 ENOG4105CVE Lytic murein transglycosylase HU055_RS04030 ENOG4107TH8 cina domain protein HU055_RS04035 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HU055_RS04040 ENOG4105Y3E Modulates RecA activity (By similarity) HU055_RS04045 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HU055_RS04050 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HU055_RS04075 ENOG4107VXZ Hydrolase HU055_RS04080 ENOG4105W39 Membrane HU055_RS04085 ENOG4105D9M gamma-glutamylcysteine synthetase HU055_RS04095 ENOG4108JU6 CBS domain protein HU055_RS04100 ENOG4106KVJ cytochrome C assembly protein HU055_RS04105 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HU055_RS04110 ENOG4105K5M 30s ribosomal protein S16 HU055_RS04125 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HU055_RS04150 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HU055_RS04165 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HU055_RS04170 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HU055_RS04175 ENOG4105C34 Pseudouridine synthase HU055_RS04180 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HU055_RS04185 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HU055_RS04220 ENOG4107NA1 Endonuclease Exonuclease phosphatase HU055_RS04230 ENOG4105E9H Lytic Murein transglycosylase HU055_RS04235 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HU055_RS04245 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HU055_RS04250 ENOG4107RZZ dna polymerase iii epsilon subunit HU055_RS04260 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HU055_RS04270 ENOG410633P Hydantoin racemase HU055_RS04285 ENOG4107QMH DNA methylase HU055_RS04290 ENOG4106H3A restriction HU055_RS04310 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HU055_RS04330 ENOG4105DRP amino acid AbC transporter HU055_RS04335 ENOG4105E5Q amino acid AbC transporter HU055_RS04345 ENOG4105C5R Aminotransferase HU055_RS04360 ENOG4105VT2 5-hydroxyisourate hydrolase HU055_RS04370 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HU055_RS04375 ENOG4105CHM Aminotransferase HU055_RS04390 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HU055_RS04395 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) HU055_RS04400 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HU055_RS04405 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HU055_RS04410 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HU055_RS04415 ENOG4107QPN acyl-Coa dehydrogenase HU055_RS04420 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HU055_RS04425 ENOG4105E7A Glutamine amidotransferase HU055_RS04430 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HU055_RS04435 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HU055_RS04440 ENOG4105CIN aminoacyl-histidine dipeptidase HU055_RS04445 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) HU055_RS04450 ENOG4105V1F Fermentation respiration switch protein HU055_RS04465 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HU055_RS04470 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HU055_RS04475 ENOG4105WD1 Membrane HU055_RS04480 ENOG41082CG Protein CrcB homolog HU055_RS04495 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) HU055_RS04535 ENOG4108JQ7 (ABC) transporter HU055_RS04545 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HU055_RS04550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HU055_RS04555 ENOG4105DEF Extracellular solute-binding protein, family 5 HU055_RS04580 ENOG4105CNT hydrolase family 2 HU055_RS04585 ENOG4105VIF phosphate starvation-inducible protein HU055_RS04595 ENOG4105II7 pyrroline-5-carboxylate reductase HU055_RS04600 ENOG4108UPT UPF0178 protein HU055_RS04605 ENOG4105G4C Periplasmic ligand-binding sensor protein HU055_RS04610 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HU055_RS04615 ENOG4105SS3 HU055_RS04635 ENOG4105HBA AroM protein HU055_RS04640 ENOG4105NBK UPF0345 protein HU055_RS04645 ENOG4105DH7 May be involved in recombination (By similarity) HU055_RS04670 ENOG4106B0W Curli production assembly transport component CsgG HU055_RS04680 ENOG4107Y60 (LipO)protein HU055_RS04685 ENOG4105EYH Exonuclease HU055_RS04690 ENOG4107RH8 nuclease SbcCD subunit D HU055_RS04695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HU055_RS04700 ENOG4105BZU Histidine kinase HU055_RS04705 ENOG4105DJH phosphate HU055_RS04715 ENOG4105CWM branched-chain amino acid transport system II carrier protein HU055_RS04720 ENOG4105C85 amino acid HU055_RS04725 ENOG4105D3R alkyl hydroperoxide reductase HU055_RS04730 ENOG4108ZYK Acyl carrier protein phosphodiesterase HU055_RS04735 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HU055_RS04745 ENOG4105CKK Glycosyl transferase, family 2 HU055_RS04750 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HU055_RS04755 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HU055_RS04760 ENOG4105VIE preprotein translocase, subunit YajC HU055_RS04765 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HU055_RS04770 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HU055_RS04780 ENOG4109066 lysm domain bon superfamily protein HU055_RS04785 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HU055_RS04790 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HU055_RS04795 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HU055_RS04800 ENOG4107YIM Involved in the transcription termination process (By similarity) HU055_RS04805 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HU055_RS04810 ENOG4108ZAI phosphatidylglycerophosphatase a HU055_RS04815 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HU055_RS04820 ENOG4105CTB Polyprenyl synthetase HU055_RS04825 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HU055_RS04830 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HU055_RS04835 ENOG4107S0N DJ-1 family HU055_RS04840 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HU055_RS04845 ENOG4108VPT UPF0234 protein HU055_RS04850 ENOG4107RDB Major Facilitator HU055_RS04855 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HU055_RS04860 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HU055_RS04865 ENOG4105CCU oxidase (Subunit III) HU055_RS04870 ENOG4105BZ9 Cytochrome C oxidase, subunit I HU055_RS04875 ENOG4105E2S oxidase) subunit II HU055_RS04880 ENOG4105EYM Major Facilitator superfamily HU055_RS04885 ENOG4105IEY (LipO)protein HU055_RS04890 ENOG4105M85 Bola protein HU055_RS04895 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HU055_RS04910 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HU055_RS04920 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HU055_RS04925 ENOG4105K70 DNA-binding protein HU055_RS04930 ENOG4105EIN peptidylprolyl cis-trans isomerase HU055_RS04935 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HU055_RS04940 ENOG4108TGP Thioesterase superfamily protein HU055_RS04945 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HU055_RS04950 ENOG4105DWP Membrane HU055_RS04955 ENOG4108XM1 transcriptional regulator AsnC family HU055_RS04960 ENOG4105BZ1 (ABC) transporter HU055_RS04965 ENOG4105BZ1 (ABC) transporter HU055_RS04970 ENOG4108YZA Nitrogen regulatory protein pii HU055_RS04975 ENOG4105BZU Histidine kinase HU055_RS04980 ENOG4105C29 acyl-CoA thioesterase HU055_RS04985 ENOG4108MNP Glycoprotein polysaccharide metabolism HU055_RS04990 ENOG41080UX Methyltransferase HU055_RS05005 ENOG4108UKR Biofilm formation regulator YbaJ HU055_RS05015 ENOG4105YK5 50S ribosomal protein L36 HU055_RS05020 ENOG4105NRA 50s ribosomal protein l31 type b HU055_RS05025 ENOG4105BZS acriflavin resistance protein HU055_RS05030 ENOG4105C1P efflux transporter, rnd family, mfp subunit HU055_RS05035 ENOG4107XI7 Tetr family transcriptional regulator HU055_RS05040 ENOG4106428 Protein of unknown function (DUF2496) HU055_RS05055 ENOG4105WD1 Membrane HU055_RS05060 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HU055_RS05065 ENOG4107QMP dna polymerase iii subunits gamma and tau HU055_RS05070 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HU055_RS05075 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HU055_RS05080 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HU055_RS05085 ENOG4105DZ2 Transcriptional regulator HU055_RS05110 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HU055_RS05115 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HU055_RS05120 ENOG4107RE1 Inosine-guanosine kinase HU055_RS05130 ENOG4105CKD glutathione-regulated potassium-efflux system protein HU055_RS05135 ENOG4105EU0 Major facilitator Superfamily HU055_RS05140 ENOG4105CGH 5'-nucleotidase HU055_RS05155 ENOG4108Z66 YbaK ebsC protein HU055_RS05160 ENOG4105MBR gumn family HU055_RS05165 ENOG4105C59 p-type ATPase HU055_RS05170 ENOG4108Z6Z Transcriptional regulator HU055_RS05175 ENOG4105G5H Membrane HU055_RS05180 ENOG4107QX8 SPFH domain, Band 7 family protein HU055_RS05185 ENOG4107QR8 Thioredoxin HU055_RS05190 ENOG4105E1F short-chain dehydrogenase reductase HU055_RS05215 ENOG4108UJV acyl-CoA thioesterase i HU055_RS05220 ENOG4108I0Y (ABC) transporter HU055_RS05225 ENOG4105CV6 ABC transporter, permease HU055_RS05230 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HU055_RS05235 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HU055_RS05245 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HU055_RS05250 ENOG4105C8N cysteinyl-tRNA synthetase HU055_RS05255 ENOG4105DQ4 alcohol dehydrogenase HU055_RS05260 ENOG4105WQ3 Rna-binding protein HU055_RS05265 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HU055_RS05275 ENOG4108KU3 Integrase HU055_RS05300 ENOG4108Z9K Osmotically inducible protein HU055_RS05315 ENOG4105C3R Methionine synthase HU055_RS05330 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HU055_RS05335 ENOG4108JQ5 ABC transporter HU055_RS05350 ENOG4105CHB tonB-dependent Receptor HU055_RS05355 ENOG4105DZG Dehydrogenase HU055_RS05360 ENOG41069ZX HU055_RS05365 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HU055_RS05370 ENOG4105CKK Glycosyl transferase, family 2 HU055_RS05375 ENOG4105C3I Nad-dependent epimerase dehydratase HU055_RS05380 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HU055_RS05385 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HU055_RS05390 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HU055_RS05405 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HU055_RS05410 ENOG4105C4M (Ubiquinol oxidase) subunit I HU055_RS05425 ENOG4105MVE transcriptional regulator HU055_RS05430 ENOG4105ZXK Dehydrogenase HU055_RS05435 ENOG4105G63 Type III effector Hrp-dependent HU055_RS05440 ENOG4105FB2 class II Aldolase HU055_RS05445 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HU055_RS05450 ENOG4105C6Z Gluconate HU055_RS05455 ENOG4105C6Z Gluconate HU055_RS05460 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HU055_RS05475 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HU055_RS05480 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HU055_RS05485 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HU055_RS05490 ENOG4108Z43 UPF0250 protein HU055_RS05495 ENOG4105DZ1 carboxypeptidase HU055_RS05500 ENOG4105K6T rare lipoprotein A HU055_RS05505 ENOG4105CNI cell division protein FtsW HU055_RS05510 ENOG4105CJN penicillin-binding protein HU055_RS05515 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HU055_RS05520 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HU055_RS05530 ENOG4105DJF DNA polymerase III, delta' subunit HU055_RS05535 ENOG4108U2H Rare lipoprotein B HU055_RS05540 ENOG4105C8T Leucyl-tRNA synthetase HU055_RS05545 ENOG4107PAI alpha helical protein HU055_RS05550 ENOG4105CDA abc transporter atp-binding protein HU055_RS05555 ENOG4105DRP amino acid AbC transporter HU055_RS05560 ENOG4105EAD ABC transporter HU055_RS05565 ENOG4107RP9 extracellular solute-binding protein, family 3 HU055_RS05570 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HU055_RS05575 ENOG4108JU5 Magnesium and cobalt efflux protein HU055_RS05580 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HU055_RS05585 ENOG4105C9A Phoh family HU055_RS05590 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HU055_RS05595 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HU055_RS05630 ENOG4105CAQ asparagine synthetase HU055_RS05635 ENOG4105D4U had-superfamily hydrolase, subfamily iia HU055_RS05640 ENOG4105E2R ROK family HU055_RS05645 ENOG4105CE4 GlcNAc 6-P deacetylase HU055_RS05650 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HU055_RS05655 ENOG4105CI1 PTS System HU055_RS05660 ENOG4105CX6 glutaminyL-tRNA synthetase HU055_RS05665 ENOG4105CIC tryptophan-specific transport protein HU055_RS05670 ENOG41090R7 Ferric uptake HU055_RS05675 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HU055_RS05680 ENOG4105NNH LexA regulated protein HU055_RS05685 ENOG4105EV9 Alpha Beta Hydrolase HU055_RS05695 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HU055_RS05700 ENOG4105EEX Two component transcriptional regulator (Winged helix family HU055_RS05705 ENOG4105XIQ Protein of unknown function (DUF2517) HU055_RS05710 ENOG4107SEY Conserved Protein HU055_RS05715 ENOG4105CVP deoxyribo-dipyrimidine photolyase HU055_RS05720 ENOG4107QNR UPF0135 protein HU055_RS05725 ENOG4105P4J Allophanate hydrolase, subunit 1 HU055_RS05730 ENOG4107R7A Allophanate hydrolase subunit 2 HU055_RS05735 ENOG4105E7W lamb ycsf family protein HU055_RS05740 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HU055_RS05750 ENOG4105BZN citrate synthase HU055_RS05755 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HU055_RS05760 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HU055_RS05765 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HU055_RS05770 ENOG4105E33 succinate dehydrogenase HU055_RS05775 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HU055_RS05780 ENOG4105C7S Dehydrogenase HU055_RS05785 ENOG4105CMV Succinyl-CoA synthetase subunit beta HU055_RS05790 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HU055_RS05795 ENOG4107YD3 Thioesterase HU055_RS05800 ENOG4105E02 MotA TolQ exbB proton channel HU055_RS05815 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HU055_RS05820 ENOG4105KCK Peptidoglycan-associated lipoprotein HU055_RS05825 ENOG4105UFD tol-pal system protein YbgF HU055_RS05885 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HU055_RS05890 ENOG4105PGM cation diffusion facilitator family transporter HU055_RS05895 ENOG4105JND homeobox protein HU055_RS05900 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HU055_RS05920 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HU055_RS05925 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HU055_RS05930 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HU055_RS05935 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HU055_RS05940 ENOG4105DKW ABC transporter HU055_RS05945 ENOG4105F4R Transcriptional regulator mode HU055_RS05955 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HU055_RS05960 ENOG4105E0C molybdate abc transporter HU055_RS05970 ENOG4108K4B hydrolase HU055_RS05975 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HU055_RS05980 ENOG4108V1U phospholipid-binding protein HU055_RS05985 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HU055_RS05990 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HU055_RS05995 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HU055_RS06000 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HU055_RS06010 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HU055_RS06015 ENOG4108IV0 ABC, transporter HU055_RS06020 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HU055_RS06025 ENOG4105CHW UPF0052 protein HU055_RS06030 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HU055_RS06035 ENOG4108RIR Molybdenum cofactor biosynthesis protein HU055_RS06040 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HU055_RS06045 ENOG4105M00 molybdopterin converting factor, subunit 1 HU055_RS06050 ENOG4108ZAF Molybdopterin HU055_RS06055 ENOG4107QS8 (LipO)protein HU055_RS06060 ENOG4105HFZ Membrane HU055_RS06070 ENOG4105C1J atp-dependent rna helicase HU055_RS06075 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HU055_RS06080 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HU055_RS06085 ENOG4105BZP glycoside hydrolase 15-related HU055_RS06090 ENOG4105KHU inner membrane protein YohD HU055_RS06095 ENOG41069YE inner membrane protein yohC HU055_RS06100 ENOG41061WM D-Alanyl-D-Alanine HU055_RS06105 ENOG4105EGS Mechanosensitive ion channel HU055_RS06115 ENOG4105CXG d-lactate dehydrogenase HU055_RS06120 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HU055_RS06130 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HU055_RS06150 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HU055_RS06165 ENOG4105EMU Dehydrogenase HU055_RS06175 ENOG4108XDN Transcriptional regulator HU055_RS06190 ENOG4105DVT helicase HU055_RS06195 ENOG4108MTB glycosyl transferase family HU055_RS06200 ENOG4105CH2 amidohydrolase HU055_RS06205 ENOG4105CGP Urocanate hydratase HU055_RS06210 ENOG4105C84 Histidine ammonia-lyase HU055_RS06215 ENOG4105CZE histidine utilization repressor HU055_RS06220 ENOG41090B9 response to stress HU055_RS06225 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HU055_RS06230 ENOG4105CI2 imidazolone-5-propionate hydrolase HU055_RS06240 ENOG4108ZIE 5 nucleotidase deoxy cytosolic type C HU055_RS06245 ENOG4105EW6 flavin reductase domain protein, FMN-binding HU055_RS06260 ENOG4105C4X radical SAM domain protein HU055_RS06270 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HU055_RS06275 ENOG4105D8X mechanosensitive ion channel HU055_RS06285 ENOG4105CDA abc transporter atp-binding protein HU055_RS06290 ENOG4105E5Q amino acid AbC transporter HU055_RS06295 ENOG4107R0W ABC transporter HU055_RS06300 ENOG4105KSC Transcriptional regulator, TraR DksA family HU055_RS06305 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HU055_RS06315 ENOG4108T1M outer membrane protein x HU055_RS06320 ENOG4105KST dependent repressor HU055_RS06325 ENOG4105CW7 secretion protein, HlyD family HU055_RS06330 ENOG4105C0R drug resistance transporter emrb qaca subfamily HU055_RS06335 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HU055_RS06345 ENOG4107QNK )-transporter HU055_RS06350 ENOG4105C5H ABC transporter HU055_RS06355 ENOG4105D06 uba thif-type nad fad binding protein HU055_RS06360 ENOG4105CVM Molybdenum cofactor synthesis domain protein HU055_RS06365 ENOG4105D44 asparaginase HU055_RS06370 ENOG4108JQ6 ABC transporter HU055_RS06390 ENOG4105DZ1 carboxypeptidase HU055_RS06395 ENOG4105C44 Serine transporter HU055_RS06410 ENOG41090BQ Glutaredoxin HU055_RS06420 ENOG4108DBC nitroreductase HU055_RS06425 ENOG4108RMJ sensory transduction regulator HU055_RS06430 ENOG4107RUE extracellular solute-binding protein family 1 HU055_RS06435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HU055_RS06445 ENOG4105D38 putrescine abc transporter HU055_RS06450 ENOG4105RBQ inner membrane protein ybjO HU055_RS06455 ENOG4106TNF Periplasmic binding protein HU055_RS06460 ENOG4105DMR ABC, transporter HU055_RS06465 ENOG4105GBT ABC transporter HU055_RS06470 ENOG4106PMH Extracellular solute-binding protein family 3 HU055_RS06475 ENOG4105E5Z arginine transporter ATP-binding subunit HU055_RS06480 ENOG41064MM (LipO)protein HU055_RS06485 ENOG4105K8R UPF0145 protein HU055_RS06490 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HU055_RS06500 ENOG4105C5W Aldolase HU055_RS06505 ENOG4105C7K acetolactate synthase HU055_RS06510 ENOG4105CPB ATP-dependent endonuclease of the OLD family HU055_RS06515 ENOG4105VEQ Cold shock protein HU055_RS06525 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HU055_RS06530 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HU055_RS06540 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HU055_RS06545 ENOG4108JJ8 (ABC) transporter HU055_RS06550 ENOG4108JJ9 ABC, transporter HU055_RS06555 ENOG4105C3M thioredoxin reductase HU055_RS06560 ENOG4105EW9 transcriptional regulator AsnC family HU055_RS06565 ENOG4105CNU cell division protein FtsK HU055_RS06570 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HU055_RS06575 ENOG4105D1H recombination factor protein RarA HU055_RS06580 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HU055_RS06585 ENOG4108ISG Major Facilitator HU055_RS06595 ENOG4105DDY UPF0142 protein ycaO HU055_RS06600 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HU055_RS06605 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HU055_RS06610 ENOG4105CAT Cytidine monophosphate kinase HU055_RS06615 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HU055_RS06620 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HU055_RS06625 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HU055_RS06630 ENOG4105BZ1 (ABC) transporter HU055_RS06635 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HU055_RS06640 ENOG4105W49 UPF0434 protein HU055_RS06645 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HU055_RS06650 ENOG4107S90 membrAne HU055_RS06655 ENOG4106371 Methyltransferase HU055_RS06660 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HU055_RS06665 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HU055_RS06670 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HU055_RS06675 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HU055_RS06680 ENOG4105EAQ (twin-arginine translocation) pathway signal HU055_RS06685 ENOG4105C5X domain protein HU055_RS06690 ENOG4105CGF Aromatic amino acid aminotransferase HU055_RS06700 ENOG4105C5S asparaginyl-tRNA synthetase HU055_RS06705 ENOG4107RH7 Nicotinate phosphoribosyltransferase HU055_RS06710 ENOG4105CD8 aminopeptidase N HU055_RS06720 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HU055_RS06730 ENOG4105GVF (ABC) transporter HU055_RS06735 ENOG4108UZX fmn reductase HU055_RS06740 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HU055_RS06745 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HU055_RS06750 ENOG4105QVC MOSC domain-containing protein HU055_RS06755 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HU055_RS06760 ENOG4105C5H ABC transporter HU055_RS06765 ENOG4105F1S paraquat-inducible protein a HU055_RS06770 ENOG4105DY2 Paraquat-inducible protein b HU055_RS06775 ENOG4108Q2G (LipO)protein HU055_RS06780 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HU055_RS06785 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HU055_RS06790 ENOG4105DAN ATP-dependent protease HU055_RS06795 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HU055_RS06810 ENOG4108RZ1 DNA transformation protein HU055_RS06815 ENOG4105EM2 membrane HU055_RS06820 ENOG410901E Membrane HU055_RS06825 ENOG41088T4 Helicase IV HU055_RS06830 ENOG4108Z5K methylglyoxal synthase HU055_RS06840 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) HU055_RS06845 ENOG4105DR4 Methyltransferase HU055_RS06850 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HU055_RS06855 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HU055_RS06860 ENOG4108MN8 Membrane HU055_RS06880 ENOG4105D6F Phosphatase HU055_RS06885 ENOG4105C26 Dehydrogenase HU055_RS06890 ENOG4105XH3 HU055_RS06900 ENOG4108R86 Transcriptional regulator HU055_RS06910 ENOG4105C85 amino acid HU055_RS06915 ENOG4105VJY transcriptional regulator HU055_RS06925 ENOG4105RA2 Membrane HU055_RS06930 ENOG4105XVG cytoplasmic protein HU055_RS06935 ENOG4105WH1 Two component transcriptional regulator luxr family HU055_RS06940 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HU055_RS06945 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HU055_RS06970 ENOG41067TZ transcriptional regulator, MarR family HU055_RS06985 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HU055_RS07000 ENOG4107RZC phospholipase d HU055_RS07015 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HU055_RS07020 ENOG4105NAC (LipO)protein HU055_RS07025 ENOG4108W47 Acidic protein msyB HU055_RS07030 ENOG4105D1S lipid A biosynthesis HU055_RS07035 ENOG4105C72 UPF0176 protein HU055_RS07045 ENOG4105DS1 cytochrome b561 HU055_RS07050 ENOG4105F76 Sarcosine oxidase HU055_RS07055 ENOG4105PVA Biofilm formation regulatory protein BssS HU055_RS07060 ENOG4105MEA DNA damage-inducible protein i HU055_RS07065 ENOG4105EKE dihydroorotase HU055_RS07070 ENOG4105F3T (LipO)protein HU055_RS07075 ENOG4105E9S glutaredoxin 2 HU055_RS07080 ENOG4105D9U N-acetyltransferase HU055_RS07090 ENOG4105CJR Integral membrane protein (MviN HU055_RS07095 ENOG4105QVD Flagella synthesis protein FlgN HU055_RS07100 ENOG4105M9M anti-sigma28 factor FlgM HU055_RS07105 ENOG4105CKS Flagella basal body P-ring formation protein flgA HU055_RS07110 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HU055_RS07115 ENOG4108ZC9 flagellar basal-body rod protein flgc HU055_RS07120 ENOG4105W00 Flagellar hook capping protein HU055_RS07125 ENOG4105BZE flagellar hook protein, FlgE HU055_RS07130 ENOG4108KPB Flagellar basal-body rod protein FlgF HU055_RS07135 ENOG4105CGA flagellar basal-body rod protein FlgG HU055_RS07145 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HU055_RS07150 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HU055_RS07155 ENOG4105E1Q flagellar hook-associated protein HU055_RS07160 ENOG4105DTJ flagellar hook-associated protein HU055_RS07165 ENOG4107QQB Ribonuclease E HU055_RS07165 ENOG4107QQB Ribonuclease E HU055_RS07170 ENOG4105EI2 Pseudouridine synthase HU055_RS07175 ENOG4108UHJ MAF-like protein HU055_RS07180 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HU055_RS07185 ENOG4105VGS 50s ribosomal protein l32 HU055_RS07190 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HU055_RS07195 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HU055_RS07200 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HU055_RS07205 ENOG4105CHR reductase HU055_RS07210 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HU055_RS07215 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HU055_RS07220 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HU055_RS07225 ENOG4105HHA aminodeoxychorismate lyase HU055_RS07230 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HU055_RS07235 ENOG4107QRG dna polymerase iii HU055_RS07240 ENOG4105F8V Hydrolase, tatD family HU055_RS07245 ENOG4105CI1 PTS System HU055_RS07250 ENOG4105K59 histidine triad (HIT) protein HU055_RS07260 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HU055_RS07270 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HU055_RS07280 ENOG4105CEP NADH dehydrogenase HU055_RS07285 ENOG4107MBR 17 kDa surface antigen HU055_RS07290 ENOG4108JA2 transcriptioN-repair coupling factor HU055_RS07295 ENOG4105C3Q Glycosyl transferase, family 2 HU055_RS07320 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HU055_RS07325 ENOG4105VS8 Flagellar biosynthetic protein fliq HU055_RS07330 ENOG4105CN7 Flagellar biosynthetic protein FliP HU055_RS07335 ENOG4105K0P flagellar biosynthesis protein HU055_RS07340 ENOG4105DD5 Flagellar motor switch protein HU055_RS07345 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HU055_RS07350 ENOG4107ZI8 flagellar basal body-associated protein flil HU055_RS07355 ENOG4105WF4 Flagellar hook-length control protein HU055_RS07360 ENOG4105GSA Flagellar export protein flij HU055_RS07365 ENOG4108JIR Flagellum-specific ATP synthase HU055_RS07370 ENOG41090PJ Flagellar assembly protein HU055_RS07375 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HU055_RS07380 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HU055_RS07385 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HU055_RS07410 ENOG4105BZU Histidine kinase HU055_RS07415 ENOG4105D60 lipoprotein releasing system transmembrane protein HU055_RS07420 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HU055_RS07425 ENOG4105D60 lipoprotein releasing system transmembrane protein HU055_RS07430 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HU055_RS07435 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HU055_RS07440 ENOG4105DKK Benzoate HU055_RS07445 ENOG4108JCI Transcriptional regulator HU055_RS07450 ENOG4105EZE Cupin 4 family protein HU055_RS07460 ENOG4105XJC Two component transcriptional regulator (Winged helix family HU055_RS07465 ENOG4107QTF adenylosuccinate lyase HU055_RS07470 ENOG41075W9 High frequency lysogenization protein HflD homolog HU055_RS07475 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HU055_RS07485 ENOG4108R99 pseudouridine synthase HU055_RS07490 ENOG4108HMX isocitrate dehydrogenase (NADP) HU055_RS07520 ENOG4105Y50 Virulence Protein HU055_RS07530 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HU055_RS07535 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HU055_RS07540 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HU055_RS07545 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HU055_RS07550 ENOG4105Y3U Transglycosylase-associated protein HU055_RS07560 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HU055_RS07575 ENOG4107GFK fumarate HU055_RS07595 ENOG4108MRH transcriptional regulatory protein HU055_RS07600 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HU055_RS07605 ENOG4105M5B (LipO)protein HU055_RS07610 ENOG4105M5B (LipO)protein HU055_RS07620 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HU055_RS07645 ENOG4106BTR HU055_RS07650 ENOG4105Y7Q type iii secretion HU055_RS07660 ENOG4105YY8 Transcriptional regulator HU055_RS07675 ENOG4108HR8 type iii secretion HU055_RS07685 ENOG4108JIR Flagellum-specific ATP synthase HU055_RS07705 ENOG41075IY surface presentation of antigens protein SpaP HU055_RS07710 ENOG4105U07 type iii secretion HU055_RS07715 ENOG4108TN6 type iii secretion HU055_RS07720 ENOG4108M6W surface presentation of antigens protein SpaS HU055_RS07725 ENOG4108Z19 type iii secretion HU055_RS07740 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HU055_RS07750 ENOG410854A Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HU055_RS07760 ENOG4105C3G gtp-binding protein HU055_RS07765 ENOG4105CHH sulfate transporter HU055_RS07775 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HU055_RS07780 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HU055_RS07785 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HU055_RS07790 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HU055_RS07795 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HU055_RS07800 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HU055_RS07805 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HU055_RS07810 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HU055_RS07815 ENOG4108YY7 Invasion gene expression up-regulator SirB HU055_RS07820 ENOG41063JG Transcriptional regulator HU055_RS07825 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HU055_RS07830 ENOG41090X5 Heat shock protein hslJ HU055_RS07835 ENOG4105EWV Sodium calcium exchanger membrane region HU055_RS07840 ENOG4105WBN Transcriptional regulator (LacI family HU055_RS07845 ENOG4108HKT sucrose-6-phosphate hydrolase HU055_RS07865 ENOG4108NH8 Cation transport protein HU055_RS07895 ENOG4105ID0 Putative invasin HU055_RS07900 ENOG4105FCK Membrane HU055_RS07905 ENOG4105C8Y Acetylornithine aminotransferase HU055_RS07910 ENOG4105F4X arginine HU055_RS07915 ENOG4105C26 Dehydrogenase HU055_RS07920 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HU055_RS07925 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HU055_RS07930 ENOG4108SPG Periplasmic Protein HU055_RS07935 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HU055_RS07940 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HU055_RS07945 ENOG4105C2C drug resistance transporter, Bcr CflA HU055_RS07950 ENOG4105KKI DNA-binding transcriptional activator OsmE HU055_RS07960 ENOG4108ETY sodium dicarboxylate symporter HU055_RS07965 ENOG4107K5X Membrane-bound metal-dependent hydrolase HU055_RS07970 ENOG4107PN8 YfeABCD locus regulator HU055_RS07980 ENOG4105P10 Uncharacterized protein ydiZ HU055_RS07985 ENOG4108NE3 Salt-induced outer membrane protein HU055_RS07990 ENOG4105C22 threonyL-tRNA synthetase HU055_RS08000 ENOG41082NX 50s ribosomal protein l35 HU055_RS08005 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HU055_RS08015 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HU055_RS08025 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HU055_RS08035 ENOG4108V06 Glutathione peroxidase HU055_RS08040 ENOG4108QBX (LipO)protein HU055_RS08050 ENOG4105CNG UPF0061 protein HU055_RS08055 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HU055_RS08060 ENOG4105EHG Permease protein HU055_RS08065 ENOG4107R4I Periplasmic binding protein HU055_RS08070 ENOG4106QJH hemin transport protein HU055_RS08080 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HU055_RS08085 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HU055_RS08095 ENOG4105IPI Membrane HU055_RS08110 ENOG4108Z4V iron-sulfur cluster assembly HU055_RS08115 ENOG4105DIW FeS assembly protein SUFB HU055_RS08120 ENOG4105C3K feS assembly ATPase SufC HU055_RS08125 ENOG4105JRK feS assembly protein SufD HU055_RS08135 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HU055_RS08145 ENOG4105CA9 Pyruvate kinase HU055_RS08160 ENOG4107QI1 Mate efflux family protein HU055_RS08165 ENOG4108R6K riboflavin synthase, subunit alpha HU055_RS08170 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HU055_RS08175 ENOG4105CZQ inner membrane transport protein YdhC HU055_RS08180 ENOG4105F52 Transcriptional regulator HU055_RS08185 ENOG4105ETE Transcriptional regulator (LacI family HU055_RS08190 ENOG4105K4H Nlp p60 protein HU055_RS08195 ENOG4105M2J Glutaredoxin HU055_RS08200 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HU055_RS08205 ENOG4108UYE Lactoylglutathione lyase HU055_RS08210 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HU055_RS08220 ENOG4105DIJ Phosphoethanolamine transferase HU055_RS08240 ENOG4105XZD Fe-S protein HU055_RS08255 ENOG4108XTF Outer Membrane Lipoprotein HU055_RS08260 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HU055_RS08265 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HU055_RS08270 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HU055_RS08275 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HU055_RS08285 ENOG4108K3A Glutathione S-transferase HU055_RS08295 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HU055_RS08310 ENOG4105CSM endonuclease III HU055_RS08315 ENOG4105DZB Electron transport complex HU055_RS08320 ENOG4108UQQ Electron transport complex HU055_RS08325 ENOG4105D6A Electron transport complex HU055_RS08330 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HU055_RS08335 ENOG4108R3D Electron transport complex HU055_RS08340 ENOG4105DGN Electron transport complex HU055_RS08345 ENOG4105M9B inner membrane protein ydgK HU055_RS08350 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HU055_RS08355 ENOG4105EF1 ribulokinase HU055_RS08360 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HU055_RS08370 ENOG4105CNN ABC, transporter HU055_RS08380 ENOG4105D9R oxidoreductase HU055_RS08385 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HU055_RS08390 ENOG4106J39 exported protein HU055_RS08395 ENOG4105C9Q fumarate hydratase class II HU055_RS08400 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HU055_RS08415 ENOG4106NZI LysR family Transcriptional regulator HU055_RS08420 ENOG4105DAG ROK family HU055_RS08425 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HU055_RS08430 ENOG4105C0R drug resistance transporter emrb qaca subfamily HU055_RS08440 ENOG4105M5Q UPF0482 protein HU055_RS08445 ENOG4105EMU Dehydrogenase HU055_RS08450 ENOG4107QUY Guanine deaminase HU055_RS08455 ENOG4105DGW oligopeptidase A HU055_RS08460 ENOG41061H0 Monooxygenase HU055_RS08470 ENOG4108VMM UPF0756 membrane protein HU055_RS08480 ENOG4105D82 Glutamate dehydrogenase HU055_RS08485 ENOG4105RKW reductase (By HU055_RS08510 ENOG4105YA8 Transcriptional regulator HU055_RS08530 ENOG41061RM osmotically inducible lipoprotein HU055_RS08545 ENOG4105CH6 catalase HU055_RS08560 ENOG4105C8Q Methyl-accepting chemotaxis HU055_RS08565 ENOG4107B2H carbonic anhydrase HU055_RS08575 ENOG4105DWT malate dehydrogenase (quinone) HU055_RS08600 ENOG4107SCK Monooxygenase HU055_RS08620 ENOG4105GGE ribonuclease HU055_RS08635 ENOG4105UEI Transcriptional Regulator AraC Family HU055_RS08645 ENOG4105F27 Major Facilitator HU055_RS08650 ENOG4107T8P acyl-Coa dehydrogenase HU055_RS08670 ENOG4105FBW Monooxygenase HU055_RS08675 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HU055_RS08680 ENOG4108JU7 Transcriptional regulator HU055_RS08685 ENOG4105DEF Extracellular solute-binding protein, family 5 HU055_RS08690 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HU055_RS08700 ENOG4105C8Q Methyl-accepting chemotaxis HU055_RS08710 ENOG4105D2S major facilitator superfamily HU055_RS08730 ENOG4108DG9 Smr protein MutS2 HU055_RS08740 ENOG4105Q9Y Universal stress protein HU055_RS08755 ENOG4105S5I Membrane HU055_RS08765 ENOG4105C5D exported protein HU055_RS08770 ENOG4105D5Q Arginine ornithine antiporter HU055_RS08780 ENOG4107EXC regulatoR HU055_RS08835 ENOG4107R08 Integrase HU055_RS08840 ENOG4105JJR Histidine kinase HU055_RS08845 ENOG4105CTD carboxy-peptidase HU055_RS08855 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HU055_RS08860 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HU055_RS08865 ENOG4105CQ7 ATP-dependent helicase HU055_RS08870 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HU055_RS08875 ENOG4108BAS reductase HU055_RS08880 ENOG4105WXT Conserved Protein HU055_RS08885 ENOG410689M (LipO)protein HU055_RS08890 ENOG4107H52 Dicarboxylate transport HU055_RS08895 ENOG4105C5I Dehydrogenase HU055_RS08910 ENOG4105C1J atp-dependent rna helicase HU055_RS08920 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HU055_RS08935 ENOG4105UMR response to DNA damage stimulus HU055_RS08940 ENOG4108S1B Periplasmic chaperone protein HU055_RS08945 ENOG4105E6S usher protein( HU055_RS08965 ENOG4107QSI ABC, transporter HU055_RS08970 ENOG4107S8C mandelate racemase muconate lactonizing HU055_RS08975 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HU055_RS08985 ENOG4106K28 UPF0283 membrane protein HU055_RS08990 ENOG4105CM6 amino acid regulated cytosolic protein HU055_RS08995 ENOG4105NNG Peripheral inner membrane phage-shock protein HU055_RS09000 ENOG4105FM1 phage shock protein C HU055_RS09005 ENOG4105YYT phage shock protein B HU055_RS09010 ENOG41087YS Phage shock protein A HU055_RS09015 ENOG4105E51 psp operon transcriptional activator HU055_RS09020 ENOG4108J59 Extracellular solute-binding protein, family 5 HU055_RS09025 ENOG4108I5W peptide transport system, permease protein HU055_RS09030 ENOG4108EU3 peptide transport system, permease HU055_RS09035 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HU055_RS09040 ENOG4108JQ2 peptide transport system atp-binding protein HU055_RS09050 ENOG4105Q4T oxidoreductase HU055_RS09055 ENOG4105DUM transcriptional regulator, lysR family HU055_RS09080 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HU055_RS09085 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HU055_RS09090 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HU055_RS09105 ENOG4108ZJT translation initiation factor, Sui1 HU055_RS09110 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HU055_RS09115 ENOG4105CFV Tetratricopeptide repeat protein HU055_RS09120 ENOG4105Q4A inner membrane protein yciS HU055_RS09125 ENOG4105EYK Phosphatidylglycerophosphatase B HU055_RS09135 ENOG4107QM5 aconitate hydratase HU055_RS09150 ENOG4107R11 Transcriptional regulator HU055_RS09155 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HU055_RS09160 ENOG4105ERU peptidase HU055_RS09165 ENOG4105UBK short-chain dehydrogenase reductase HU055_RS09175 ENOG4107RTD sua5 ycio yrdc ywlc family protein HU055_RS09185 ENOG4105CRQ synthase (Component I) HU055_RS09190 ENOG4108EFP Anthranilate synthase component II HU055_RS09195 ENOG4108I0Q anthranilate phosphoribosyltransferase HU055_RS09200 ENOG4105DK0 Indole-3-glycerol phosphate synthase HU055_RS09205 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HU055_RS09210 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HU055_RS09220 ENOG4105EIF outer membrane protein W HU055_RS09230 ENOG4107835 probably involved in intracellular septation (By similarity) HU055_RS09235 ENOG4105NAU thioesterase Superfamily protein HU055_RS09240 ENOG410822N TonB family HU055_RS09245 ENOG4105K9H YciI-like protein HU055_RS09255 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HU055_RS09260 ENOG4108W5H UPF0263 protein HU055_RS09265 ENOG4108JQ7 (ABC) transporter HU055_RS09270 ENOG4105C3U ABC transporter HU055_RS09275 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HU055_RS09280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HU055_RS09285 ENOG4107QSI ABC, transporter HU055_RS09290 ENOG4108J59 Extracellular solute-binding protein, family 5 HU055_RS09295 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HU055_RS09305 ENOG4105D2S major facilitator superfamily HU055_RS09320 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HU055_RS09325 ENOG4107F9Y LysR family transcriptional regulator HU055_RS09335 ENOG4105JSC dimethylmenaquinone methyltransferase HU055_RS09385 ENOG4105C6Y Udp-glucose 6-dehydrogenase HU055_RS09390 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HU055_RS09395 ENOG4105I93 response regulator HU055_RS09400 ENOG4105K5B UPF0225 protein HU055_RS09405 ENOG4105CIY formyltetrahydrofolate deformylase HU055_RS09440 ENOG4105CGK Exodeoxyribonuclease III HU055_RS09445 ENOG4105MTM Protein of unknown function (DUF1496) HU055_RS09450 ENOG4108IYH Dna topoisomerase HU055_RS09455 ENOG41069NU Nitroreductase HU055_RS09460 ENOG4105D07 Signal peptide peptidase, SppA HU055_RS09465 ENOG4105HDK L-asparaginase HU055_RS09470 ENOG4108RWI nicotinamidase HU055_RS09475 ENOG4105VUT cytoplasmic protein HU055_RS09480 ENOG4105E0X reductase HU055_RS09490 ENOG4105DSB aldose 1-epimerase HU055_RS09495 ENOG4105CV8 reductase HU055_RS09500 ENOG4105GNX MltA-interacting MipA family protein HU055_RS09505 ENOG4105CYN Serine protein kinase HU055_RS09510 ENOG4106AKX UPF0229 protein HU055_RS09525 ENOG4105D3Q Sugar transferase HU055_RS09535 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HU055_RS09540 ENOG4105MWK D-amino acid dehydrogenase, small subunit HU055_RS09545 ENOG4105ED1 spovr family HU055_RS09550 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) HU055_RS09555 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HU055_RS09560 ENOG4108ZZ3 UPF0260 protein HU055_RS09565 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HU055_RS09570 ENOG4105VNG YcgL domain-containing protein HU055_RS09575 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HU055_RS09580 ENOG4107QMS site-determining protein HU055_RS09585 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) HU055_RS09595 ENOG4105CEY Amp-dependent synthetase and ligase HU055_RS09600 ENOG4105Y4Z Outer Membrane Lipoprotein HU055_RS09605 ENOG41072GX Peptidase M22 Glycoprotease HU055_RS09610 ENOG4105DVT helicase HU055_RS09615 ENOG4105M4H endoribonuclease L-psp HU055_RS09620 ENOG4105X5C UPF0181 protein HU055_RS09630 ENOG4105P8F nudix hydrolase HU055_RS09635 ENOG4105EJQ L-serine dehydratase HU055_RS09640 ENOG4105EE5 Membrane protein terC HU055_RS09645 ENOG4105DHI Methyltransferase HU055_RS09665 ENOG4105Q3Y exported protein HU055_RS09670 ENOG4105TIK HU055_RS09675 ENOG4105D0M Protease HtpX homolog HU055_RS09680 ENOG4105CN1 protease HU055_RS09685 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HU055_RS09690 ENOG4108ZGC gaf domain protein HU055_RS09695 ENOG4105H2K paraquat-inducible protein a HU055_RS09700 ENOG4105DY2 Paraquat-inducible protein b HU055_RS09705 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HU055_RS09720 ENOG4105F4G Membrane HU055_RS09740 ENOG4105NKT exported protein HU055_RS09760 ENOG4105MPK DNA polymerase III subunit theta HU055_RS09770 ENOG4105UMD exodeoxyribonuclease X HU055_RS09775 ENOG4105CUG Oligopeptidase b HU055_RS09785 ENOG4105X2V dna damage-inducible protein HU055_RS09790 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HU055_RS09795 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HU055_RS09800 ENOG4105CA9 Pyruvate kinase HU055_RS09810 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HU055_RS09815 ENOG4105DR5 peptidase HU055_RS09820 ENOG4105NXV High-affinity zinc uptake system protein HU055_RS09830 ENOG4105FAV ABC, transporter HU055_RS09835 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HU055_RS09840 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HU055_RS09845 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HU055_RS09850 ENOG4105CDY transcriptional regulatory protein HU055_RS09855 ENOG4108TIT dATP pyrophosphohydrolase HU055_RS09860 ENOG4105C9M aspartyl-trna synthetase HU055_RS09865 ENOG41081XQ Conserved Protein HU055_RS09870 ENOG4105WJG Glutathione HU055_RS09875 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HU055_RS09880 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HU055_RS09890 ENOG4106N3A copper homeostasis protein cutc HU055_RS09895 ENOG4105C87 Aminotransferase class I and II HU055_RS09900 ENOG4106ZCM YecM protein HU055_RS09905 ENOG4105C75 arginyL-tRNA synthetase HU055_RS09910 ENOG4105W13 flagellar protein HU055_RS09915 ENOG4105D7B Flagellar biosynthesis protein flha HU055_RS09920 ENOG4105D00 flagellar biosynthetic protein flhB HU055_RS09930 ENOG4108VYJ response regulator receiver protein HU055_RS09935 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HU055_RS09940 ENOG4105BZU Histidine kinase HU055_RS09955 ENOG4105C8Q Methyl-accepting chemotaxis HU055_RS09960 ENOG4108V3W Chemotaxis protein, CheW HU055_RS09965 ENOG4105CBS Chea signal transduction histidine kinase HU055_RS09970 ENOG4105ER2 Ompa motb domain protein HU055_RS09975 ENOG4107RD7 Flagellar Motor Protein, MotA HU055_RS09980 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HU055_RS09985 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HU055_RS09990 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HU055_RS09995 ENOG4108K4C ec 3.1.3.12 HU055_RS10005 ENOG4105KT5 UmuD protein HU055_RS10010 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HU055_RS10015 ENOG4105D52 delta-aminolevulinic acid dehydratase HU055_RS10020 ENOG4108YYH Nadph-dependent fmn reductase HU055_RS10030 ENOG4105ER6 polysaccharide biosynthesis protein HU055_RS10035 ENOG4105K64 Glycosyl transferase, family 2 HU055_RS10040 ENOG4105ETS cytosine purines uracil thiamine allantoin HU055_RS10045 ENOG4105C26 Dehydrogenase HU055_RS10055 ENOG4107XHZ cytoplasmic chaperone TorD family protein HU055_RS10080 ENOG4108DBC nitroreductase HU055_RS10095 ENOG4105D5M phosphate starvation-inducible protein HU055_RS10100 ENOG4105DBE peroxidase HU055_RS10110 ENOG4105EKT )-iron permease HU055_RS10115 ENOG4105CK7 Sodium proline symporter HU055_RS10120 ENOG4105C26 Dehydrogenase HU055_RS10125 ENOG4105IQC Inner membrane protein YcfT HU055_RS10135 ENOG4108M9K flagella biosynthesis protein FliZ HU055_RS10140 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HU055_RS10150 ENOG4105I03 Flagellin HU055_RS10150 ENOG4105I03 Flagellin HU055_RS10155 ENOG4105DTS flagellar hook-associated HU055_RS10160 ENOG4105MQ3 flagellar protein FliS HU055_RS10170 ENOG4105E5K Alpha-amylase HU055_RS10175 ENOG4105JCU Inherit from NOG: (Lipo)protein HU055_RS10185 ENOG4105VNZ cytoplasmic protein HU055_RS10190 ENOG4105CKW Inner membrane protein yedI HU055_RS10200 ENOG41090BB DNA mismatch endonuclease (vsr) HU055_RS10210 ENOG4105WPN DNA integration recombination invertion protein HU055_RS10215 ENOG4105EST Metal Dependent Phosphohydrolase HU055_RS10225 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HU055_RS10235 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HU055_RS10240 ENOG4105DSE periplasmic solute binding protein HU055_RS10245 ENOG4105DIK (ABC) transporter HU055_RS10250 ENOG4105CC5 ABC transporter HU055_RS10255 ENOG4105CC5 ABC transporter HU055_RS10285 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HU055_RS10295 ENOG4108JQ6 ABC transporter HU055_RS10300 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HU055_RS10305 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HU055_RS10310 ENOG4105DEF Extracellular solute-binding protein, family 5 HU055_RS10330 ENOG4107WN4 Polygalacturonase HU055_RS10355 ENOG4105N14 lysine exporter protein LysE YggA HU055_RS10360 ENOG4107R11 Transcriptional regulator HU055_RS10400 ENOG4105FYV Amp nucleosidase HU055_RS10410 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HU055_RS10420 ENOG4105F7P transcriptional regulator AsnC family HU055_RS10440 ENOG4105CM2 brancheD-chain amino acid aminotransferase HU055_RS10445 ENOG41061WN bacilysin biosynthesis protein HU055_RS10465 ENOG4105EV9 Alpha Beta Hydrolase HU055_RS10470 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HU055_RS10475 ENOG4105UQX Mate efflux family protein HU055_RS10480 ENOG41090HJ UPF0265 protein HU055_RS10485 ENOG4105DR8 Membrane HU055_RS10490 ENOG4105CJB Exodeoxyribonuclease I HU055_RS10495 ENOG4105CUB amino acid HU055_RS10500 ENOG4107SRH Nad-dependent epimerase dehydratase HU055_RS10510 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HU055_RS10520 ENOG4105CIH Imidazole acetol-phosphate transaminase HU055_RS10525 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HU055_RS10530 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HU055_RS10535 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HU055_RS10540 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HU055_RS10545 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HU055_RS10550 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HU055_RS10555 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HU055_RS10610 ENOG4105CMR udp-glucose 4-epimerase HU055_RS10615 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HU055_RS10620 ENOG4105PSV Polysaccharide Biosynthesis Protein HU055_RS10625 ENOG4107T8Q Glycosyl transferase (Group 1 HU055_RS10630 ENOG4105C74 pyruvyl transferase HU055_RS10640 ENOG4108RYC glycosyltransferase HU055_RS10645 ENOG4105CG5 Glycosyl transferase (Group 1 HU055_RS10655 ENOG4105JEU Glycosyl transferase, family 2 HU055_RS10660 ENOG4105D75 Capsular exopolysaccharide family HU055_RS10665 ENOG4107ZF2 Phosphatase HU055_RS10670 ENOG4105DAY polysaccharide export protein HU055_RS10675 ENOG4105D3Q Sugar transferase HU055_RS10680 ENOG4105EE5 Membrane protein terC HU055_RS10685 ENOG4108GAE asmA family HU055_RS10690 ENOG4105DHP deoxycytidine triphosphate deaminase HU055_RS10695 ENOG4105DBI uridine monophosphokinase HU055_RS10700 ENOG4105MH5 phosphoesterase PA-phosphatase related protein HU055_RS10705 ENOG4105BZU Histidine kinase HU055_RS10710 ENOG4105R8A Heat shock protein HU055_RS10725 ENOG4105BZS acriflavin resistance protein HU055_RS10735 ENOG4105EB3 Histidine kinase HU055_RS10740 ENOG4105E3W Two component transcriptional regulator (Winged helix family HU055_RS10760 ENOG4107TE5 Lipid kinase HU055_RS10765 ENOG4105DWF phosphomethylpyrimidine kinase HU055_RS10770 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HU055_RS10780 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HU055_RS10795 ENOG4105D1F ATP-binding protein HU055_RS10800 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HU055_RS10810 ENOG41067MG lrgb family HU055_RS10815 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HU055_RS10820 ENOG4107R1I NAD-dependent malic enzyme HU055_RS10825 ENOG4107GZ4 SanA protein HU055_RS10830 ENOG4107SDZ Galactoside transport system permease protein mglC HU055_RS10835 ENOG4105C2J ABC transporter HU055_RS10845 ENOG41060NJ transcriptional regulator HU055_RS10850 ENOG4105DHF Membrane HU055_RS10855 ENOG4105EUJ GTP cyclohydrolase i HU055_RS10860 ENOG4105EGI Transcriptional regulator HU055_RS10880 ENOG4105E0A ABC, transporter HU055_RS10885 ENOG4105EHG Permease protein HU055_RS10890 ENOG4108IQI permease HU055_RS10895 ENOG4105DUM transcriptional regulator, lysR family HU055_RS10900 ENOG4105HMI Membrane HU055_RS10905 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HU055_RS10910 ENOG4105DM4 PTS System HU055_RS10915 ENOG4105DE4 1-phosphofructokinase HU055_RS10920 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HU055_RS10925 ENOG4105KRS Proteinase inhibitor HU055_RS10930 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HU055_RS10935 ENOG41076MN Phosphoesterase, PA-phosphatase related HU055_RS10940 ENOG4107TT5 NLP P60 protein HU055_RS10945 ENOG4105CXC rtn protein HU055_RS10950 ENOG4105E43 Extracellular solute-binding protein, family 5 HU055_RS10955 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HU055_RS10960 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HU055_RS10965 ENOG4108JQ5 ABC transporter HU055_RS10970 ENOG4105HG6 HU055_RS10975 ENOG4105C2C drug resistance transporter, Bcr CflA HU055_RS10980 ENOG4105I08 Pseudouridine synthase HU055_RS10985 ENOG4105CFI type iii restriction protein res subunit HU055_RS10990 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HU055_RS10995 ENOG4106V8H Nucleoid-associated protein HU055_RS11000 ENOG4105YDX UPF0352 protein HU055_RS11005 ENOG4105E68 Sulfatase HU055_RS11065 ENOG4108TSE Transferase HU055_RS11075 ENOG4105CF1 Alkylated DNA repair protein HU055_RS11080 ENOG4105CJ2 (LipO)protein HU055_RS11090 ENOG4105FCK Membrane HU055_RS11105 ENOG41068CG regulatoR HU055_RS11110 ENOG4105BZU Histidine kinase HU055_RS11115 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HU055_RS11120 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HU055_RS11125 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HU055_RS11130 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HU055_RS11135 ENOG4105XPH Ferredoxin HU055_RS11155 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HU055_RS11165 ENOG4105DFH Transport of potassium into the cell (By similarity) HU055_RS11170 ENOG4105TNS Conserved Protein HU055_RS11175 ENOG4105DJ9 glucan biosynthesis protein HU055_RS11180 ENOG4107YB6 acetyltransferase, (GNAT) family HU055_RS11195 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU055_RS11200 ENOG4105C8S subunit m HU055_RS11205 ENOG4105D65 subunit l HU055_RS11210 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU055_RS11215 ENOG4107UFS subunit j HU055_RS11220 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU055_RS11225 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HU055_RS11230 ENOG4108IEH NADH dehydrogenase subunit g HU055_RS11235 ENOG4107QIZ NADH dehydrogenase HU055_RS11240 ENOG4105GKE subunit e HU055_RS11245 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU055_RS11250 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HU055_RS11255 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HU055_RS11260 ENOG4107NQ8 LysR family Transcriptional regulator HU055_RS11265 ENOG4105CHM Aminotransferase HU055_RS11270 ENOG4105DK2 UPF0207 protein HU055_RS11290 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HU055_RS11295 ENOG4105PQ6 UPF0208 membrane protein HU055_RS11300 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HU055_RS11305 ENOG4105C6K Malic enzyme HU055_RS11310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HU055_RS11320 ENOG4108JPW Aminotransferase HU055_RS11330 ENOG4105F38 ABC transporter, permease HU055_RS11335 ENOG4105D38 putrescine abc transporter HU055_RS11340 ENOG4105PTV Nudix Hydrolase HU055_RS11350 ENOG4105ECP epimerase HU055_RS11355 ENOG4108JEH abc transporter atp-binding protein HU055_RS11360 ENOG4106YG3 ABC transporter HU055_RS11365 ENOG4105DSP amino acid AbC transporter HU055_RS11370 ENOG4105E89 ABC transporter HU055_RS11375 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HU055_RS11380 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HU055_RS11385 ENOG4105E96 Colicin v production protein HU055_RS11390 ENOG4108S3P Sporulation domain protein HU055_RS11395 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HU055_RS11400 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HU055_RS11410 ENOG4105DQR SNARE associated Golgi HU055_RS11420 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HU055_RS11440 ENOG4106WZ1 flagella biosynthesis regulator HU055_RS11475 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HU055_RS11480 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HU055_RS11485 ENOG4105MH2 YfcL protein HU055_RS11490 ENOG4108BPE -transporting atpase HU055_RS11495 ENOG4105EJ9 Membrane HU055_RS11505 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HU055_RS11510 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HU055_RS11515 ENOG4108DG9 Smr protein MutS2 HU055_RS11520 ENOG4108BY2 phosphohistidine phosphatase HU055_RS11525 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HU055_RS11530 ENOG4105CHU acetyl-coa acetyltransferase HU055_RS11545 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HU055_RS11550 ENOG410903C (LipO)protein HU055_RS11555 ENOG4105KWW Biogenesis protein HU055_RS11560 ENOG4105KWW Biogenesis protein HU055_RS11570 ENOG4105DA4 cytochrome c-type biogenesis protein HU055_RS11580 ENOG4105X3C heme exporter protein HU055_RS11585 ENOG41060IM Heme exporter protein HU055_RS11590 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HU055_RS11615 ENOG4105BZU Histidine kinase HU055_RS11625 ENOG4105CUY Mechanosensitive ion channel HU055_RS11665 ENOG4105CHM Aminotransferase HU055_RS11680 ENOG4105CHC glucokinase (EC 2.7.1.2) HU055_RS11685 ENOG4107RA9 decarboxylase HU055_RS11690 ENOG4105CPC Aldo Keto reductase HU055_RS11700 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HU055_RS11705 ENOG4105D9N nucleoside HU055_RS11720 ENOG4105TMB Formate nitrite transporter HU055_RS11725 ENOG4105HZG regulatoR HU055_RS11730 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HU055_RS11775 ENOG4108M0I Transcriptional regulator HU055_RS11780 ENOG4105DHU Bile acid HU055_RS11785 ENOG4105VRT cytoplasmic protein HU055_RS11790 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HU055_RS11795 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HU055_RS11800 ENOG4105EXN Sulfate transport protein CysZ HU055_RS11805 ENOG4105C6T cysteine synthase HU055_RS11810 ENOG4105KZ7 phosphocarrier protein hpr HU055_RS11815 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HU055_RS11820 ENOG4105C5Y PTS System HU055_RS11825 ENOG4105E0F Histidine kinase HU055_RS11830 ENOG4105E3W Two component transcriptional regulator (Winged helix family HU055_RS11835 ENOG4105C6T cysteine synthase HU055_RS11840 ENOG4108IJ6 ABC transporter HU055_RS11845 ENOG4105ECW sulfate abc transporter HU055_RS11850 ENOG4108I5D sulfate abc transporter HU055_RS11855 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HU055_RS11860 ENOG4105E7K (LipO)protein HU055_RS11865 ENOG4105QZU Inner membrane protein YfeZ HU055_RS11875 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HU055_RS11880 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HU055_RS11885 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HU055_RS11890 ENOG4105CV1 Transketolase (EC 2.2.1.1) HU055_RS11895 ENOG4107VIJ nudix hydrolase HU055_RS11900 ENOG4105C85 amino acid HU055_RS11905 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HU055_RS11910 ENOG4105BZU Histidine kinase HU055_RS11915 ENOG4105WH1 Two component transcriptional regulator luxr family HU055_RS11920 ENOG4105BZS acriflavin resistance protein HU055_RS11935 ENOG4105KUZ arsenate reductase HU055_RS11940 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HU055_RS11945 ENOG4105XYK UPF0370 protein HU055_RS11960 ENOG4105CNA YD repeat protein HU055_RS11980 ENOG4105CNA YD repeat protein HU055_RS11995 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HU055_RS12000 ENOG4105CGZ zinc metallopeptidase HU055_RS12005 ENOG4105C8V SAICAR synthetase HU055_RS12010 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HU055_RS12015 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HU055_RS12020 ENOG4105RH4 Glycine cleavage system transcriptional repressor HU055_RS12025 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HU055_RS12030 ENOG4105BZU Histidine kinase HU055_RS12040 ENOG4105K89 arsenate reductase HU055_RS12045 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HU055_RS12050 ENOG4105C2W permease HU055_RS12055 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HU055_RS12060 ENOG4105CXB phosphoribosylaminoimidazole synthetase HU055_RS12065 ENOG4108V3E phosphoribosylglycinamide formyltransferase HU055_RS12070 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HU055_RS12075 ENOG4105E2Z phosphate ABC transporter (Permease HU055_RS12080 ENOG4105C8U phosphate abc transporter HU055_RS12085 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HU055_RS12090 ENOG4105C9X ppx gppa phosphatase HU055_RS12095 ENOG41088CC tellurite resistance protein tehB HU055_RS12100 ENOG4105BZU Histidine kinase HU055_RS12105 ENOG4105CJW magnesium transporter HU055_RS12110 ENOG4105CSP Major Facilitator Superfamily HU055_RS12115 ENOG4105EXW epimerase dehydratase HU055_RS12125 ENOG4105D3G Pseudouridine synthase HU055_RS12130 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HU055_RS12160 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HU055_RS12165 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HU055_RS12170 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HU055_RS12175 ENOG4105D4Y metalloprotease HU055_RS12185 ENOG4105DZG Dehydrogenase HU055_RS12195 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HU055_RS12200 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HU055_RS12205 ENOG4105N21 Membrane HU055_RS12210 ENOG4105CUT histidyl-tRNA synthetase HU055_RS12215 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HU055_RS12220 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HU055_RS12230 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HU055_RS12235 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HU055_RS12240 ENOG4105KHC sulfurtransferase HU055_RS12245 ENOG4105DG4 malate L-lactate dehydrogenase HU055_RS12250 ENOG4105CZJ Aldehyde dehydrogenase HU055_RS12270 ENOG4105CTU Proline racemase HU055_RS12280 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HU055_RS12285 ENOG4107QTZ amino acid HU055_RS12290 ENOG4105YYA enhanced serine sensitivity protein SseB HU055_RS12295 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HU055_RS12300 ENOG4105C3J Cysteine desulfurase HU055_RS12305 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HU055_RS12310 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HU055_RS12315 ENOG4105ECY inositol monophosphatase HU055_RS12320 ENOG4108MN2 Stationary phase inducible protein CsiE HU055_RS12325 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HU055_RS12330 ENOG4108YZA Nitrogen regulatory protein pii HU055_RS12335 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HU055_RS12340 ENOG4108SKK alpha helix protein HU055_RS12345 ENOG4107WP9 Histidine kinase HU055_RS12350 ENOG4108ETH Formylglycinamide ribotide synthetase HU055_RS12355 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HU055_RS12360 ENOG4108Z6B deaminase HU055_RS12365 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HU055_RS12370 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HU055_RS12375 ENOG4106G6Q Transcriptional regulator HU055_RS12385 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HU055_RS12390 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HU055_RS12395 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HU055_RS12400 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HU055_RS12405 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HU055_RS12410 ENOG4105C3F Signal peptidase i HU055_RS12415 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HU055_RS12430 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HU055_RS12435 ENOG4105VQK sigma E regulatory protein, MucB RseB HU055_RS12450 ENOG4108IYU L-aspartate oxidase HU055_RS12455 ENOG4108IYU L-aspartate oxidase HU055_RS12460 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HU055_RS12465 ENOG4105C1J atp-dependent rna helicase HU055_RS12470 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HU055_RS12475 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HU055_RS12480 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HU055_RS12485 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HU055_RS12490 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HU055_RS12495 ENOG4105VDB UPF0125 protein HU055_RS12500 ENOG4108Z1B Cyclase dehydrase HU055_RS12505 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HU055_RS12520 ENOG4105E12 capsule polysaccharide HU055_RS12530 ENOG4108V3W Chemotaxis protein, CheW HU055_RS12540 ENOG4105ER2 Ompa motb domain protein HU055_RS12545 ENOG4107RD7 Flagellar Motor Protein, MotA HU055_RS12550 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HU055_RS12555 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) HU055_RS12560 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HU055_RS12565 ENOG4105C8Q Methyl-accepting chemotaxis HU055_RS12570 ENOG4105DTJ flagellar hook-associated protein HU055_RS12575 ENOG4105E1Q flagellar hook-associated protein HU055_RS12580 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HU055_RS12585 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HU055_RS12590 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HU055_RS12595 ENOG4105CGA flagellar basal-body rod protein FlgG HU055_RS12600 ENOG4108KPB Flagellar basal-body rod protein FlgF HU055_RS12605 ENOG4105BZE flagellar hook protein, FlgE HU055_RS12610 ENOG4105W00 Flagellar hook capping protein HU055_RS12615 ENOG4108ZC9 flagellar basal-body rod protein flgc HU055_RS12620 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HU055_RS12625 ENOG4105CKS Flagella basal body P-ring formation protein flgA HU055_RS12635 ENOG4105QVD Flagella synthesis protein FlgN HU055_RS12645 ENOG4105MQ3 flagellar protein FliS HU055_RS12650 ENOG4105DTS flagellar hook-associated HU055_RS12680 ENOG4106R49 Methyltransferase HU055_RS12685 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HU055_RS12695 ENOG4105CN7 Flagellar biosynthetic protein FliP HU055_RS12700 ENOG4105K0P flagellar biosynthesis protein HU055_RS12705 ENOG4105DD5 Flagellar motor switch protein HU055_RS12710 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HU055_RS12715 ENOG4107ZI8 flagellar basal body-associated protein flil HU055_RS12720 ENOG4105WF4 Flagellar hook-length control protein HU055_RS12730 ENOG4108JIR Flagellum-specific ATP synthase HU055_RS12735 ENOG41090PJ Flagellar assembly protein HU055_RS12740 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HU055_RS12745 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HU055_RS12750 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HU055_RS12755 ENOG4105BZU Histidine kinase HU055_RS12765 ENOG4108VYJ response regulator receiver protein HU055_RS12775 ENOG4105D00 flagellar biosynthetic protein flhB HU055_RS12780 ENOG4105D7B Flagellar biosynthesis protein flha HU055_RS12790 ENOG4105DRB nucleoside-specific channel-forming protein HU055_RS12795 ENOG4108MK9 spermidine N(1)-acetyltransferase HU055_RS12805 ENOG4108WMJ Protein of unknown function (DUF2002) HU055_RS12810 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HU055_RS12815 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HU055_RS12820 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HU055_RS12825 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HU055_RS12830 ENOG4108IJ7 Glycine betaine HU055_RS12840 ENOG4105GIJ Glycine betaine HU055_RS12845 ENOG4105EQ0 Major Facilitator superfamily HU055_RS12850 ENOG4105NTK Transcriptional repressor Mpra HU055_RS12855 ENOG4105CW7 secretion protein, HlyD family HU055_RS12860 ENOG4105C0R drug resistance transporter emrb qaca subfamily HU055_RS12865 ENOG4105EIB trna rrna methyltransferase HU055_RS12870 ENOG4105K63 Thioredoxin HU055_RS12875 ENOG4106IUH DTW domain containing protein HU055_RS12885 ENOG4105JIM Phosphatidylserine synthase HU055_RS12890 ENOG4105T42 (LipO)protein HU055_RS12895 ENOG4105CSH Transporter HU055_RS12925 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HU055_RS12930 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HU055_RS12935 ENOG4108UMI ABC transporter, permease HU055_RS12940 ENOG4105D01 (LipO)protein HU055_RS12945 ENOG4108R8X outer membrane lipoprotein HU055_RS12950 ENOG4108R96 Methyltransferase, YaeB family HU055_RS12955 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HU055_RS12965 ENOG4108YZN class I peptide chain release factor HU055_RS12970 ENOG4108VWS Yaeq family HU055_RS12980 ENOG4105M1T rho-binding antiterminator HU055_RS12990 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HU055_RS12995 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HU055_RS13000 ENOG4105CXN decarboxylase HU055_RS13005 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HU055_RS13010 ENOG4105C0B DNA polymerase III (alpha subunit) HU055_RS13015 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HU055_RS13020 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HU055_RS13025 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HU055_RS13030 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HU055_RS13035 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HU055_RS13040 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HU055_RS13045 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HU055_RS13050 ENOG4105DZP Membrane-associated zinc metalloprotease HU055_RS13055 ENOG4105KNE Phosphatidate cytidylyltransferase HU055_RS13060 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HU055_RS13065 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HU055_RS13070 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HU055_RS13075 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HU055_RS13080 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HU055_RS13085 ENOG4105CE9 30S ribosomal protein S2 HU055_RS13090 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HU055_RS13095 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HU055_RS13100 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HU055_RS13105 ENOG4108T8E UPF0325 protein HU055_RS13110 ENOG4105C0H protease HU055_RS13115 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HU055_RS13120 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HU055_RS13130 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HU055_RS13135 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HU055_RS13140 ENOG4105S6R Iron-hydroxamate transporter permease subunit HU055_RS13145 ENOG4105J76 Periplasmic binding protein HU055_RS13150 ENOG4105E0A ABC, transporter HU055_RS13165 ENOG4105K4U addiction module toxin, RelE StbE family HU055_RS13185 ENOG4105CNA YD repeat protein HU055_RS13195 ENOG4105BZ4 penicillin-binding protein HU055_RS13200 ENOG4105CQ7 ATP-dependent helicase HU055_RS13205 ENOG4107XID 2'-5' rna ligase HU055_RS13210 ENOG4105PW4 Sugar fermentation stimulation protein homolog HU055_RS13215 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HU055_RS13220 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HU055_RS13225 ENOG4105DJ0 Poly(A) Polymerase HU055_RS13230 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HU055_RS13235 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HU055_RS13240 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HU055_RS13245 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HU055_RS13250 ENOG4105E3A (ABC) transporter HU055_RS13255 ENOG4105DA5 (ABC) transporter HU055_RS13260 ENOG41077A9 carbonic anhydrase HU055_RS13265 ENOG4108UGV hypoxanthine phosphoribosyltransferase HU055_RS13280 ENOG4105E3B Multicopper oxidase HU055_RS13285 ENOG4108ZRK uncharacterized protein yacC HU055_RS13290 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HU055_RS13295 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HU055_RS13300 ENOG4108ZIG UPF0231 protein HU055_RS13305 ENOG4107QIJ Aconitate hydratase 2 HU055_RS13320 ENOG4105PWE CRISPR-associated protein cas2 HU055_RS13325 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HU055_RS13330 ENOG4108Y7V CRISPR-associated protein, Cse3 family HU055_RS13335 ENOG4108VWQ crispr-associated protein HU055_RS13340 ENOG41060M0 Crispr-associated protein, cse4 family HU055_RS13345 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) HU055_RS13350 ENOG4105CYR Crispr-associated protein, cse1 family HU055_RS13355 ENOG4105DTT CRISPR-associated helicase, cas3 HU055_RS13380 ENOG4105CHU acetyl-coa acetyltransferase HU055_RS13385 ENOG4107F3J Amp-dependent synthetase and ligase HU055_RS13400 ENOG4107ZYJ bioY protein HU055_RS13405 ENOG4107QCX Transporter HU055_RS13410 ENOG4108JJB ABC transporter HU055_RS13415 ENOG4105CHR reductase HU055_RS13420 ENOG4107QN2 dihydrolipoyl dehydrogenase HU055_RS13425 ENOG4107QSN dihydrolipoamide acetyltransferase HU055_RS13430 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HU055_RS13435 ENOG41073TP transcriptional regulator HU055_RS13440 ENOG4105C85 amino acid HU055_RS13445 ENOG4105CT4 transporter HU055_RS13450 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HU055_RS13475 ENOG4106A72 regulatory protein AmpE HU055_RS13490 ENOG4108ZUW Major pilin subunit HU055_RS13495 ENOG4107QHF type ii secretion system protein e HU055_RS13500 ENOG4105D7Q type ii secretion system HU055_RS13505 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HU055_RS13515 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HU055_RS13520 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HU055_RS13525 ENOG4105M6F mutator MutT protein HU055_RS13550 ENOG4105D7Q type ii secretion system HU055_RS13565 ENOG4105X5Z General secretion pathway protein I HU055_RS13575 ENOG4108RTD type II secretion system protein K HU055_RS13600 ENOG4108M1A Chitin-binding protein HU055_RS13610 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HU055_RS13615 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HU055_RS13625 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HU055_RS13630 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HU055_RS13635 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HU055_RS13640 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HU055_RS13645 ENOG4105CPF Cell wall formation (By similarity) HU055_RS13650 ENOG4105DFU Cell wall formation (By similarity) HU055_RS13655 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HU055_RS13660 ENOG4105CNI cell division protein FtsW HU055_RS13665 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HU055_RS13675 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HU055_RS13680 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HU055_RS13685 ENOG4105CJN penicillin-binding protein HU055_RS13690 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HU055_RS13695 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HU055_RS13700 ENOG4108V6E Cell division protein mraZ HU055_RS13705 ENOG4107B7Y DNA-binding transcriptional regulator FruR HU055_RS13710 ENOG4108ZP8 Acetolactate synthase small subunit HU055_RS13715 ENOG4105C7K acetolactate synthase HU055_RS13725 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HU055_RS13730 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HU055_RS13735 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HU055_RS13740 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HU055_RS13745 ENOG4105S8Q sugar efflux transporter HU055_RS13750 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HU055_RS13755 ENOG4105DP9 ABC transporter HU055_RS13760 ENOG4106SMU thiamine transporter membrane protein HU055_RS13765 ENOG4107T0D ABC, transporter HU055_RS13770 ENOG4108KF1 Membrane HU055_RS13775 ENOG4105CQ2 DNA polymerase HU055_RS13780 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HU055_RS13785 ENOG4105D3G Pseudouridine synthase HU055_RS13790 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HU055_RS13805 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HU055_RS13810 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HU055_RS13815 ENOG4105NWN ApaG protein HU055_RS13820 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HU055_RS13825 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HU055_RS13830 ENOG4105CCF Lysine exporter protein (Lyse ygga) HU055_RS13835 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HU055_RS13840 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HU055_RS13845 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HU055_RS13850 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HU055_RS13855 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HU055_RS13860 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HU055_RS13865 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HU055_RS13870 ENOG4105DTN riboflavin biosynthesis protein ribF HU055_RS13875 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HU055_RS13880 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HU055_RS13885 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HU055_RS13890 ENOG4105CFG Acts as a chaperone (By similarity) HU055_RS13900 ENOG4108RIR Molybdenum cofactor biosynthesis protein HU055_RS13910 ENOG4105D1Q UPF0246 protein HU055_RS13920 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HU055_RS13935 ENOG41065U4 response regulator HU055_RS13940 ENOG4108RH0 Crea protein HU055_RS13945 ENOG4105UEI Transcriptional Regulator AraC Family HU055_RS13955 ENOG4105CVJ phosphoglycerate mutase HU055_RS13960 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HU055_RS13965 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HU055_RS13970 ENOG4107SC1 transglycosylase HU055_RS13980 ENOG4107FB0 transcriptional regulator DeoR family HU055_RS13990 ENOG4105C5H ABC transporter HU055_RS13995 ENOG4105CC0 LysR family Transcriptional regulator HU055_RS14000 ENOG4105CIS alcohol dehydrogenase HU055_RS14015 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HU055_RS14020 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HU055_RS14025 ENOG4105EAC phosphoserine phosphatase HU055_RS14030 ENOG41062Z9 Membrane HU055_RS14035 ENOG4105EUP HipA domain protein HU055_RS14040 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HU055_RS14045 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HU055_RS14050 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HU055_RS14055 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HU055_RS14060 ENOG4105EYA deoxyribonuclease HU055_RS14065 ENOG4108NRW Phospholipase, patatin family HU055_RS14075 ENOG4105K3G Periplasmic Protein HU055_RS14080 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HU055_RS14085 ENOG4105EXC Acyl-transferase HU055_RS14090 ENOG4108R3E Dna-3-methyladenine glycosylase i HU055_RS14095 ENOG41065RQ ADP-ribosylation crystallin J1 HU055_RS14130 ENOG4105CNA YD repeat protein HU055_RS14165 ENOG4105D9P serine threonine protein kinase HU055_RS14170 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HU055_RS14230 ENOG4108WC9 type VI secretion system effector, hcp1 family HU055_RS14260 ENOG4106VK6 Flagellar motor protein HU055_RS14280 ENOG4105PAD Hydrolase HU055_RS14285 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HU055_RS14290 ENOG4108WPU DNA polymerase III subunit psi HU055_RS14295 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HU055_RS14315 ENOG4105YBH Protein of unknown function (DUF1435) HU055_RS14320 ENOG4105BZU Histidine kinase HU055_RS14345 ENOG4105ETE Transcriptional regulator (LacI family HU055_RS14440 ENOG4105C2X Arabinose 5-phosphate isomerase HU055_RS14445 ENOG410804X Transcriptional regulator HU055_RS14450 ENOG4105J92 DNA-binding transcriptional activator GutM HU055_RS14455 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HU055_RS14460 ENOG4105VI0 Pts system, glucitol sorbitol-specific HU055_RS14465 ENOG4105DZY Pts system, glucitol sorbitol-specific HU055_RS14470 ENOG410787A Pts system, glucitol sorbitol-specific HU055_RS14480 ENOG4107VK2 coenzyme PQQ biosynthesis protein PqqF HU055_RS14485 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HU055_RS14495 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) HU055_RS14500 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) HU055_RS14510 ENOG4108IGT Dipeptidase HU055_RS14515 ENOG4105CHH sulfate transporter HU055_RS14520 ENOG41077A9 carbonic anhydrase HU055_RS14530 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HU055_RS14535 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HU055_RS14540 ENOG4108VKG metal-dependent hydrolase HU055_RS14550 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HU055_RS14555 ENOG4105CPQ Dehydrogenase HU055_RS14565 ENOG4105DU1 integral membrane protein, terc HU055_RS14570 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HU055_RS14580 ENOG4106W5V Membrane HU055_RS14585 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HU055_RS14590 ENOG4105WAY exported protein HU055_RS14595 ENOG4105NE1 Conserved Protein HU055_RS14600 ENOG41090KG Inner membrane protein YqjE HU055_RS14605 ENOG4105YJD HU055_RS14610 ENOG4108VBZ doxx family HU055_RS14620 ENOG4105CWB LysR family transcriptional Regulator HU055_RS14625 ENOG4108CNN domain protein HU055_RS14650 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HU055_RS14655 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HU055_RS14660 ENOG41082RQ UPF0102 protein HU055_RS14665 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HU055_RS14670 ENOG4105W4M Transport-associated protein HU055_RS14675 ENOG4105EMD TRANSCRIPTIONal HU055_RS14690 ENOG41069H0 dihydroorotase EC 3.5.2.3 HU055_RS14725 ENOG4105CMS peptidase U62, modulator of DNA gyrase HU055_RS14730 ENOG4105N42 UPF0307 protein HU055_RS14735 ENOG4105DFU Cell wall formation (By similarity) HU055_RS14740 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HU055_RS14745 ENOG4105C8Q Methyl-accepting chemotaxis HU055_RS14750 ENOG4105F0N pyrophosphate phospho-hydrolase HU055_RS14755 ENOG4108ZHD aig2 family HU055_RS14765 ENOG4105CFU surface antigen HU055_RS14770 ENOG4105C37 (CBS) domain HU055_RS14775 ENOG41061GZ Protein of unknown function (DUF1107) HU055_RS14780 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HU055_RS14785 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HU055_RS14790 ENOG4108V1T peptidylprolyl cis-trans isomerase HU055_RS14795 ENOG4105FHY Opacity-associated protein A HU055_RS14800 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HU055_RS14805 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HU055_RS14810 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HU055_RS14815 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HU055_RS14820 ENOG4108MXZ Esterase HU055_RS14825 ENOG4105C8Q Methyl-accepting chemotaxis HU055_RS14835 ENOG4105C2N RNA methyltransferase TrmH family group 3 HU055_RS14840 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HU055_RS14845 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HU055_RS14855 ENOG4105EPW hflc protein HU055_RS14860 ENOG4107QJR hflk protein HU055_RS14865 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HU055_RS14875 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HU055_RS14880 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HU055_RS14885 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HU055_RS14890 ENOG4105K8N protein family UPF0079, ATPase HU055_RS14895 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HU055_RS14920 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HU055_RS14925 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HU055_RS14930 ENOG4105DJ4 phosphatidylserine decarboxylase HU055_RS14935 ENOG4105EGS Mechanosensitive ion channel HU055_RS14940 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HU055_RS14945 ENOG4105QNF Outer membrane lipoprotein HU055_RS14960 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HU055_RS14965 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HU055_RS14970 ENOG4108ZVF (LipO)protein HU055_RS14975 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HU055_RS14980 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HU055_RS14985 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HU055_RS14990 ENOG4108IJ0 Aspartate ammonia-lyase HU055_RS14995 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HU055_RS15005 ENOG4108SIC Transcriptional regulator HU055_RS15020 ENOG4105E5W Transporter HU055_RS15030 ENOG4105CAQ asparagine synthetase HU055_RS15045 ENOG4105CUT histidyl-tRNA synthetase HU055_RS15060 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HU055_RS15185 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HU055_RS15245 ENOG4105DY8 decarboxylase HU055_RS15250 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HU055_RS15255 ENOG4105DUU IucA IucC family protein HU055_RS15260 ENOG4105E0K tonB-dependent siderophore receptor HU055_RS15270 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HU055_RS15280 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HU055_RS15290 ENOG4108HCJ Hydrolase HU055_RS15300 ENOG4105DYC esterase HU055_RS15310 ENOG410829K Lysine exporter protein (Lyse ygga) HU055_RS15315 ENOG4105CC0 LysR family Transcriptional regulator HU055_RS15330 ENOG410642W LysR family Transcriptional regulator HU055_RS15365 ENOG4105BZU Histidine kinase HU055_RS15370 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HU055_RS15390 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HU055_RS15395 ENOG4105CK2 sodium dicarboxylate symporter HU055_RS15400 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HU055_RS15405 ENOG41062QD Membrane HU055_RS15410 ENOG4107QN1 sodium solute HU055_RS15415 ENOG4108UII YfaZ family HU055_RS15420 ENOG41067MG lrgb family HU055_RS15430 ENOG4105CMU LysR family (Transcriptional regulator HU055_RS15435 ENOG4105EEQ Na H antiporter HU055_RS15440 ENOG4105C7N Xanthine uracil vitamin C permease HU055_RS15450 ENOG4108Z4X TRANSCRIPTIONal HU055_RS15455 ENOG4108W3Q Transcriptional regulator HU055_RS15475 ENOG4105D5K Hemolysin activator protein HU055_RS15480 ENOG4108UUM single-stranded DNA-binding protein HU055_RS15485 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HU055_RS15490 ENOG4105DQ4 alcohol dehydrogenase HU055_RS15495 ENOG4105TNG K13735 adhesin invasin HU055_RS15500 ENOG4105MSB protein, conserved in bacteria HU055_RS15505 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HU055_RS15510 ENOG4105CGF Aromatic amino acid aminotransferase HU055_RS15520 ENOG4105CDU Replicative dna helicase HU055_RS15525 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HU055_RS15530 ENOG4105P4Z Phage shock protein G HU055_RS15535 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HU055_RS15550 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HU055_RS15555 ENOG4105CKK Glycosyl transferase, family 2 HU055_RS15565 ENOG4105UZW Tail fiber assembly protein HU055_RS15610 ENOG4105HRS Antitermination protein HU055_RS15615 ENOG4108MXB Protein of unknown function (DUF968) HU055_RS15635 ENOG4105MYN Zinc uptake regulation protein HU055_RS15640 ENOG4105VDW Csbd family HU055_RS15645 ENOG4107R73 Mate efflux family protein HU055_RS15650 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HU055_RS15655 ENOG41080IJ Diacylglycerol kinase HU055_RS15670 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HU055_RS15675 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HU055_RS15680 ENOG4105E3R (LipO)protein HU055_RS15685 ENOG4108W78 Pfam:DUF1017 HU055_RS15690 ENOG4108Y9B (LipO)protein HU055_RS15700 ENOG4107QP8 phosphohexose isomerase HU055_RS15705 ENOG4105CFH Aspartokinase HU055_RS15710 ENOG4105EAM Na Pi-cotransporter HU055_RS15715 ENOG4105CVG Homoserine O-transsuccinylase HU055_RS15740 ENOG4105DC1 bifunctional purine biosynthesis protein purh HU055_RS15745 ENOG4105C12 Phosphoribosylglycinamide synthetase HU055_RS15750 ENOG4108T8B Protein of unknown function (DUF1481) HU055_RS15755 ENOG4105K70 DNA-binding protein HU055_RS15760 ENOG4105R2J Conserved Protein HU055_RS15765 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HU055_RS15770 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HU055_RS15775 ENOG4105E09 nadh pyrophosphatase HU055_RS15780 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HU055_RS15785 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HU055_RS15790 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HU055_RS15795 ENOG4108NC2 Outer membrane protease HU055_RS15840 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HU055_RS15845 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HU055_RS15850 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HU055_RS15855 ENOG4108VZM 50s ribosomal protein L10 HU055_RS15860 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HU055_RS15865 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HU055_RS15870 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HU055_RS15875 ENOG4105PM1 preprotein translocase subunit SecE HU055_RS15880 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HU055_RS15905 ENOG4105CS9 pantothenic acid kinase HU055_RS15910 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HU055_RS15915 ENOG4105D4A Cell wall formation (By similarity) HU055_RS15940 ENOG4108RR8 protoporphyrinogen oxidase HU055_RS15945 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HU055_RS15950 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HU055_RS15955 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) HU055_RS15960 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) HU055_RS15965 ENOG4105CHU acetyl-coa acetyltransferase HU055_RS15970 ENOG4107QK7 reductase HU055_RS15975 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HU055_RS15980 ENOG4105MDZ Transcriptional activator rfaH HU055_RS15990 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HU055_RS15995 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HU055_RS16000 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HU055_RS16005 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HU055_RS16010 ENOG4105JC1 sterol-binding domain protein HU055_RS16015 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HU055_RS16020 ENOG4105CGY Dna recombination protein HU055_RS16025 ENOG4107SXA Phosphorylase HU055_RS16030 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HU055_RS16035 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HU055_RS16040 ENOG4105DZ2 Transcriptional regulator HU055_RS16045 ENOG4108W15 Protein of unknown function (DUF1456) HU055_RS16050 ENOG4105CXY transporter HU055_RS16055 ENOG4105DQF Hydrolase HU055_RS16060 ENOG4108EUD Lysophospholipase HU055_RS16065 ENOG410829K Lysine exporter protein (Lyse ygga) HU055_RS16070 ENOG4105C9U ATP-dependent DNA helicase RecQ HU055_RS16075 ENOG4105HDD phospholipase HU055_RS16080 ENOG4108VUY thioesterase Superfamily protein HU055_RS16085 ENOG4107QUT magnesium and cobalt transport protein CorA HU055_RS16090 ENOG4105C4R Atp-dependent dna helicase HU055_RS16095 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HU055_RS16105 ENOG4105CT0 Protein of unknown function, DUF484 HU055_RS16110 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HU055_RS16115 ENOG4105S7Z (LipO)protein HU055_RS16120 ENOG4107T0K Adenylate cyclase HU055_RS16125 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HU055_RS16130 ENOG41076E6 Uroporphyrinogen-III Synthase HU055_RS16135 ENOG4105ECF c-methyltransferase HU055_RS16140 ENOG410601J HemY protein HU055_RS16180 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HU055_RS16185 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HU055_RS16190 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HU055_RS16195 ENOG4105EGZ biosynthesis protein HU055_RS16200 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HU055_RS16205 ENOG4108WJ1 acetyltransferase HU055_RS16210 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HU055_RS16215 ENOG4105C1B dTDP-glucose 4-6-dehydratase HU055_RS16220 ENOG4108IJ1 Dehydrogenase HU055_RS16225 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HU055_RS16230 ENOG4105SFE lipopolysaccharide biosynthesis protein HU055_RS16235 ENOG4105ESV Glycosyl transferase, family 4 HU055_RS16240 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HU055_RS16250 ENOG4105C1J atp-dependent rna helicase HU055_RS16255 ENOG4105C9X ppx gppa phosphatase HU055_RS16260 ENOG4105C4R Atp-dependent dna helicase HU055_RS16265 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HU055_RS16270 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HU055_RS16275 ENOG4105EMY transcriptional regulator HU055_RS16280 ENOG4105C7B Threonine dehydratase HU055_RS16285 ENOG4105C01 Dihydroxy-acid dehydratase HU055_RS16290 ENOG4105CM2 brancheD-chain amino acid aminotransferase HU055_RS16295 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HU055_RS16310 ENOG4105C0P Mg chelatase subunit ChlI HU055_RS16315 ENOG4108WFC UPF0438 protein yifE HU055_RS16320 ENOG4105CVI Transcriptional regulator HU055_RS16355 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HU055_RS16360 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HU055_RS16365 ENOG4108Y73 Membrane HU055_RS16370 ENOG4105EJ2 Transcriptional regulator HU055_RS16375 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HU055_RS16380 ENOG4105C5Q Transcriptional regulator HU055_RS16385 ENOG4105EHV domain protein HU055_RS16390 ENOG4105CH7 arginosuccinase HU055_RS16395 ENOG4105CDH Citrulline--aspartate ligase HU055_RS16400 ENOG4105CAS nag kinase HU055_RS16405 ENOG4105CWC Acetylornithine deacetylase HU055_RS16410 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HU055_RS16415 ENOG4105SYT Methylenetetrahydrofolate reductase HU055_RS16420 ENOG4105CFH Aspartokinase HU055_RS16425 ENOG4105C28 cystathionine HU055_RS16430 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HU055_RS16435 ENOG4105VFB Binds the 23S rRNA (By similarity) HU055_RS16440 ENOG4105C25 Primosomal protein n' HU055_RS16445 ENOG4105ETE Transcriptional regulator (LacI family HU055_RS16450 ENOG41063M6 Cell Division Protein HU055_RS16455 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HU055_RS16460 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HU055_RS16465 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HU055_RS16470 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HU055_RS16475 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HU055_RS16490 ENOG4105CBT Fructose-1,6-bisphosphatase HU055_RS16495 ENOG4105E5M Multidrug resistance protein D HU055_RS16505 ENOG4105DP0 ferredoxin-NADP reductase HU055_RS16515 ENOG4105EBK exported protein HU055_RS16520 ENOG4105CP7 Triose-phosphate isomerase HU055_RS16530 ENOG4105DWT malate dehydrogenase (quinone) HU055_RS16540 ENOG4105JAB phenazine biosynthesis protein, phzf family HU055_RS16545 ENOG4107H3J ribonuclease HU055_RS16550 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HU055_RS16555 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HU055_RS16560 ENOG4105CTQ phosphohexokinase HU055_RS16565 ENOG41076HS cation diffusion facilitator family transporter HU055_RS16570 ENOG4105FMW periplasmic HU055_RS16575 ENOG4105E3W Two component transcriptional regulator (Winged helix family HU055_RS16585 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HU055_RS16590 ENOG4105D7W serine acetyltransferase HU055_RS16595 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HU055_RS16600 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HU055_RS16605 ENOG4105VW4 glutaredoxin 3 HU055_RS16610 ENOG4107YZP Rhodanese domain protein HU055_RS16615 ENOG41063SB peptidase HU055_RS16620 ENOG4105PXI polysaccharide deacetylase HU055_RS16625 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HU055_RS16630 ENOG4105XA0 heptosyltransferase ii HU055_RS16635 ENOG4105D16 lipopolysaccharide heptosyltransferase i HU055_RS16640 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HU055_RS16645 ENOG41068PG O-Antigen polymerase HU055_RS16665 ENOG4105DKP glycosyl transferase, family 9 HU055_RS16675 ENOG4105CPK Glycosyl transferase (Group 1 HU055_RS16680 ENOG4105XA0 heptosyltransferase ii HU055_RS16685 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HU055_RS16690 ENOG4106WTF Glycosyl transferase, family 2 HU055_RS16695 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HU055_RS16700 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HU055_RS16710 ENOG4105KDC 50s ribosomal protein l28 HU055_RS16715 ENOG4105W5Q DNA repair protein (RadC HU055_RS16720 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HU055_RS16725 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HU055_RS16730 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HU055_RS16735 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HU055_RS16740 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HU055_RS16745 ENOG4105D9N nucleoside HU055_RS16755 ENOG4105DSJ YicC domain protein HU055_RS16770 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HU055_RS16825 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HU055_RS16835 ENOG41068CG regulatoR HU055_RS16840 ENOG4105EN6 Membrane HU055_RS16845 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HU055_RS16850 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HU055_RS16855 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HU055_RS16860 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HU055_RS16865 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HU055_RS16870 ENOG4105CB5 ATP-dependent DNA helicase recG HU055_RS16875 ENOG4105C2W permease HU055_RS16880 ENOG4105JV1 AsmA family HU055_RS16885 ENOG4105FE9 pseudouridine synthase HU055_RS16890 ENOG4105SUU thioesterase domain HU055_RS16895 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HU055_RS16905 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HU055_RS16910 ENOG4105CI3 gtp-binding protein typa HU055_RS16915 ENOG4105C5F glutamine synthetase HU055_RS16920 ENOG4105CUX Signal transduction histidine kinase HU055_RS16925 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HU055_RS16930 ENOG4105D4P Coproporphyrinogen iii oxidase HU055_RS16935 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HU055_RS16945 ENOG4105C2M dna polymerase I HU055_RS16950 ENOG4108Z33 Thiol disulfide Interchange Protein HU055_RS16960 ENOG4105PC1 Conserved Protein HU055_RS16995 ENOG4105C0R drug resistance transporter emrb qaca subfamily HU055_RS17000 ENOG4105ETE Transcriptional regulator (LacI family HU055_RS17005 ENOG4108RVA ribokinase HU055_RS17010 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HU055_RS17015 ENOG4105CNN ABC, transporter HU055_RS17020 ENOG4105C2J ABC transporter HU055_RS17025 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HU055_RS17030 ENOG4105C7K acetolactate synthase HU055_RS17045 ENOG4105H4F exported protein HU055_RS17065 ENOG4105DFH Transport of potassium into the cell (By similarity) HU055_RS17075 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HU055_RS17085 ENOG4108VVK transcriptional Regulator, AsnC HU055_RS17090 ENOG4105QTB Flavodoxin HU055_RS17100 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HU055_RS17105 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HU055_RS17110 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HU055_RS17115 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HU055_RS17120 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HU055_RS17125 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HU055_RS17130 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HU055_RS17135 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HU055_RS17140 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HU055_RS17145 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HU055_RS17155 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HU055_RS17165 ENOG4105EDQ levansucrase EC 2.4.1.10 HU055_RS17170 ENOG4105ZTC transcriptional activator, Ogr delta HU055_RS17175 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HU055_RS17180 ENOG4105C8U phosphate abc transporter HU055_RS17185 ENOG4105E2Z phosphate ABC transporter (Permease HU055_RS17190 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HU055_RS17200 ENOG4107RGD Major Facilitator superfamily HU055_RS17210 ENOG4105C7N Xanthine uracil vitamin C permease HU055_RS17215 ENOG4105E8Q phosphopantetheinyl transferase HU055_RS17220 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HU055_RS17225 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HU055_RS17235 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HU055_RS17240 ENOG4105VG0 50S ribosomal protein l34 HU055_RS17290 ENOG4107QJE Chromosome Partitioning Protein HU055_RS17355 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HU055_RS17380 ENOG4108NC2 Outer membrane protease