locus-tag	class	description
EPC_RS00050	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EPC_RS00200	COG0477	Major facilitator Superfamily
EPC_RS00225	COG0716	FMN binding
EPC_RS00230	COG1522	sequence-specific DNA binding
EPC_RS00240	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EPC_RS00265	COG3111	PFAM Bacterial OB fold (BOF) protein
EPC_RS00295	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPC_RS00300	COG1879	ABC-type sugar transport system periplasmic component
EPC_RS00305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPC_RS00310	COG1609	Transcriptional regulator
EPC_RS00315	COG0477	Major facilitator Superfamily
EPC_RS00340	COG0746	molybdenum cofactor guanylyltransferase activity
EPC_RS00355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPC_RS00360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPC_RS00360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPC_RS00370	COG3078	GTPase activator activity
EPC_RS00385	COG3852	Histidine kinase
EPC_RS00405	COG1011	Hydrolase
EPC_RS00415	COG1490	D-aminoacyl-tRNA deacylase activity
EPC_RS00420	COG0456	acetyltransferase
EPC_RS00425	COG1187	pseudouridine synthase activity
EPC_RS00430	COG2982	Protein involved in outer membrane biogenesis
EPC_RS00435	COG2233	PERMEase
EPC_RS00440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPC_RS00445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPC_RS00450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPC_RS00455	COG1758	RNA polymerase activity
EPC_RS00470	COG2860	membrane
EPC_RS00475	COG2197	response regulator
EPC_RS00485	COG2824	Alkylphosphonate utilization operon protein PhnA
EPC_RS00590	COG1561	YicC-like family, N-terminal region
EPC_RS00600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPC_RS00605	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EPC_RS00610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPC_RS00615	COG1309	transcriptional regulator
EPC_RS00620	COG0756	dUTP diphosphatase activity
EPC_RS00625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EPC_RS00630	COG2003	Belongs to the UPF0758 family
EPC_RS00635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EPC_RS00645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EPC_RS00650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EPC_RS00660	COG1519	Transferase
EPC_RS00665	COG0859	PFAM glycosyl transferase family 9
EPC_RS00670	COG0438	transferase activity, transferring glycosyl groups
EPC_RS00680	COG0859	PFAM glycosyl transferase family 9
EPC_RS00695	COG1215	transferase activity, transferring glycosyl groups
EPC_RS00700	COG3307	-O-antigen
EPC_RS00705	COG0438	transferase activity, transferring glycosyl groups
EPC_RS00710	COG0859	PFAM glycosyl transferase family 9
EPC_RS00715	COG0859	PFAM glycosyl transferase family 9
EPC_RS00720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPC_RS00725	COG2861	carbohydrate metabolic process
EPC_RS00730	COG4942	peptidase
EPC_RS00735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPC_RS00740	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPC_RS00745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EPC_RS00750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EPC_RS00760	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EPC_RS00765	COG2205	protein histidine kinase activity
EPC_RS00770	COG0745	RESPONSE REGULATOR receiver
EPC_RS00775	COG3678	ATP-independent chaperone mediated protein folding
EPC_RS00785	COG0205	6-phosphofructokinase activity
EPC_RS00800	COG1295	ribonuclease BN
EPC_RS00805	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EPC_RS00810	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EPC_RS00830	COG4555	ABC transporter
EPC_RS00870	COG0149	triose-phosphate isomerase activity
EPC_RS00880	COG3152	Membrane
EPC_RS00895	COG2814	Major facilitator Superfamily
EPC_RS00900	COG1494	fructose-1,6-bisphosphatase
EPC_RS00915	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPC_RS00920	COG3074	FtsZ-dependent cytokinesis
EPC_RS00925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPC_RS00930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EPC_RS00935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EPC_RS00940	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPC_RS00945	COG1609	Transcriptional regulator
EPC_RS00950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPC_RS00955	COG0254	rRNA binding
EPC_RS00980	COG1215	transferase activity, transferring glycosyl groups
EPC_RS00990	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EPC_RS00995	COG0626	cystathionine gamma-synthase activity
EPC_RS01000	COG0527	aspartate kinase activity
EPC_RS01000	COG0460	homoserine dehydrogenase
EPC_RS01015	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EPC_RS01020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPC_RS01030	COG0137	argininosuccinate synthase activity
EPC_RS01035	COG0165	Argininosuccinate lyase
EPC_RS01040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPC_RS01040	COG0678	peroxiredoxin activity
EPC_RS01050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPC_RS01055	COG1309	transcriptional regulator
EPC_RS01065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPC_RS01070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPC_RS01105	COG0583	DNA-binding transcription factor activity
EPC_RS01110	COG3085	chromosome segregation
EPC_RS01115	COG0606	chelatase, subunit chli
EPC_RS01125	COG3978	acetolactate synthase activity
EPC_RS01135	COG0129	dihydroxy-acid dehydratase activity
EPC_RS01140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPC_RS01150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EPC_RS01175	COG0248	Ppx GppA phosphatase
EPC_RS01180	COG0513	Belongs to the DEAD box helicase family
EPC_RS01185	COG3118	belongs to the thioredoxin family
EPC_RS01190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EPC_RS01195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPC_RS01205	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EPC_RS01210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EPC_RS01215	COG1088	dTDP-glucose 4,6-dehydratase activity
EPC_RS01220	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EPC_RS01225	COG0456	acetyltransferase
EPC_RS01230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPC_RS01235	COG2244	polysaccharide biosynthetic process
EPC_RS01240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EPC_RS01250	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EPC_RS01280	COG3071	HemY protein
EPC_RS01285	COG2959	enzyme of heme biosynthesis
EPC_RS01290	COG1587	Uroporphyrinogen-III synthase
EPC_RS01295	COG0181	hydroxymethylbilane synthase activity
EPC_RS01310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EPC_RS01315	COG3159	Protein conserved in bacteria
EPC_RS01325	COG1011	Hydrolase
EPC_RS01330	COG0210	DNA helicase
EPC_RS01335	COG0598	Magnesium transport protein CorA
EPC_RS01340	COG2050	protein possibly involved in aromatic compounds catabolism
EPC_RS01345	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
EPC_RS01350	COG0514	ATP-dependent DNA helicase (RecQ)
EPC_RS01355	COG1280	lysine exporter protein (LysE YggA)
EPC_RS01360	COG2267	carboxylic ester hydrolase activity
EPC_RS01365	COG0561	phosphatase activity
EPC_RS01370	COG2271	Major facilitator Superfamily
EPC_RS01375	COG4807	Protein conserved in bacteria
EPC_RS01380	COG0583	DNA-binding transcription factor activity
EPC_RS01385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EPC_RS01390	COG0412	Dienelactone hydrolase
EPC_RS01400	COG1322	Protein conserved in bacteria
EPC_RS01405	COG2226	methyltransferase
EPC_RS01415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPC_RS01425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPC_RS01430	COG0805	protein transport
EPC_RS01445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EPC_RS01455	COG0183	Belongs to the thiolase family
EPC_RS01465	COG0006	proline dipeptidase activity
EPC_RS01470	COG1739	Uncharacterized protein family UPF0029
EPC_RS01475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPC_RS01480	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EPC_RS01510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EPC_RS01515	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EPC_RS01515	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EPC_RS01520	COG1072	(Pantothenic acid kinase))
EPC_RS01545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPC_RS01555	COG0250	Participates in transcription elongation, termination and antitermination
EPC_RS01560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EPC_RS01565	COG0081	regulation of translation
EPC_RS01570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPC_RS01575	COG0222	ribosome binding
EPC_RS01580	COG0085	RNA polymerase activity
EPC_RS01585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EPC_RS01635	COG4571	Outer membrane protease
EPC_RS01645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EPC_RS01650	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EPC_RS01655	COG2816	NAD+ diphosphatase activity
EPC_RS01660	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EPC_RS01665	COG1515	deoxyribonuclease V activity
EPC_RS01685	COG0151	Belongs to the GarS family
EPC_RS01690	COG0138	bifunctional purine biosynthesis protein purh
EPC_RS01730	COG1126	abc transporter atp-binding protein
EPC_RS01735	COG0765	amino acid transport
EPC_RS01740	COG4597	amino acid ABC transporter
EPC_RS01745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPC_RS01750	COG1560	Kdo2-lipid A biosynthetic process
EPC_RS01770	COG2264	protein methyltransferase activity
EPC_RS01775	COG4145	pantothenate transmembrane transporter activity
EPC_RS01780	COG3924	membrane
EPC_RS01785	COG0439	Biotin carboxylase
EPC_RS01790	COG0511	ligase activity, forming carbon-carbon bonds
EPC_RS01795	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPC_RS01805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EPC_RS01810	COG0604	alcohol dehydrogenase
EPC_RS01815	COG2199	diguanylate cyclase activity
EPC_RS01815	COG2200	EAL domain
EPC_RS01820	COG1077	Cell shape determining protein MreB Mrl
EPC_RS01825	COG1792	Involved in formation and maintenance of cell shape
EPC_RS01830	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EPC_RS01840	COG1530	ribonuclease E activity
EPC_RS01845	COG3164	Protein of unknown function
EPC_RS01850	COG0312	modulator of DNA gyrase
EPC_RS01875	COG1566	PFAM secretion protein HlyD family protein
EPC_RS01880	COG1289	transmembrane transporter activity
EPC_RS01895	COG1438	arginine binding
EPC_RS01900	COG0039	L-malate dehydrogenase activity
EPC_RS01905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPC_RS01910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPC_RS01915	COG3105	Protein conserved in bacteria
EPC_RS01920	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EPC_RS01925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EPC_RS01930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPC_RS01935	COG0625	glutathione transferase activity
EPC_RS01940	COG2969	positive regulation of protein catabolic process
EPC_RS01970	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPC_RS01975	COG0070	glutamate synthase
EPC_RS01975	COG0069	glutamate synthase activity
EPC_RS01975	COG0067	glutamate synthase
EPC_RS01980	COG0784	Response regulator, receiver
EPC_RS01980	COG2198	Histidine kinase
EPC_RS01980	COG5002	protein histidine kinase activity
EPC_RS01990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPC_RS01995	COG1660	Displays ATPase and GTPase activities
EPC_RS02005	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPC_RS02010	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EPC_RS02015	COG1137	ATPase activity
EPC_RS02020	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EPC_RS02025	COG3117	lipopolysaccharide transmembrane transporter activity
EPC_RS02030	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EPC_RS02040	COG0530	calcium, potassium:sodium antiporter activity
EPC_RS02045	COG1127	ABC transporter
EPC_RS02050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPC_RS02055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPC_RS02060	COG2854	intermembrane phospholipid transfer
EPC_RS02065	COG3113	response to antibiotic
EPC_RS02070	COG5007	Belongs to the BolA IbaG family
EPC_RS02075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPC_RS02080	COG3423	Transcriptional regulator
EPC_RS02085	COG0142	geranyltranstransferase activity
EPC_RS02090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPC_RS02095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EPC_RS02100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EPC_RS02110	COG2027	D-alanyl-D-alanine carboxypeptidase
EPC_RS02120	COG1534	Rna-binding protein
EPC_RS02125	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EPC_RS02135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPC_RS02140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPC_RS02145	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPC_RS02160	COG0779	Required for maturation of 30S ribosomal subunits
EPC_RS02165	COG0195	Participates in both transcription termination and antitermination
EPC_RS02175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EPC_RS02180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EPC_RS02185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPC_RS02190	COG1185	polyribonucleotide nucleotidyltransferase activity
EPC_RS02200	COG0513	Belongs to the DEAD box helicase family
EPC_RS02205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPC_RS02210	COG3153	acetyltransferase
EPC_RS02220	COG3766	membrane
EPC_RS02225	COG0602	queuosine metabolic process
EPC_RS02230	COG1328	CTP reductase activity
EPC_RS02235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPC_RS02240	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EPC_RS02250	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EPC_RS02260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EPC_RS02265	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
EPC_RS02275	COG0525	valine-tRNA ligase activity
EPC_RS02280	COG2927	DNA polymerase III (CHI subunit)
EPC_RS02285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPC_RS02290	COG0795	lipopolysaccharide-transporting ATPase activity
EPC_RS02295	COG0795	lipopolysaccharide-transporting ATPase activity
EPC_RS02300	COG2733	membrane
EPC_RS02305	COG0433	COG0433 Predicted ATPase
EPC_RS02320	COG0582	viral genome integration into host DNA
EPC_RS02325	COG2801	Transposase and inactivated derivatives
EPC_RS02350	COG0277	FAD linked oxidase domain protein
EPC_RS02365	COG0367	asparagine synthase
EPC_RS02375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPC_RS02375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPC_RS02385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPC_RS02410	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EPC_RS02420	COG3012	SEC-C Motif Domain Protein
EPC_RS02420	COG3318	Belongs to the UPF0149 family
EPC_RS02425	COG1464	Belongs to the NlpA lipoprotein family
EPC_RS02435	COG3423	Transcriptional regulator
EPC_RS02440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EPC_RS02455	COG3663	DNA glycosylase
EPC_RS02460	COG0840	transmembrane signaling receptor activity
EPC_RS02470	COG0358	DNA primase activity
EPC_RS02475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPC_RS02480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPC_RS02485	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EPC_RS02490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPC_RS02495	COG1968	undecaprenyl-diphosphatase activity
EPC_RS02500	COG0617	tRNA 3'-terminal CCA addition
EPC_RS02505	COG4991	sh3 domain protein
EPC_RS02510	COG3025	triphosphatase activity
EPC_RS02520	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPC_RS02520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPC_RS02525	COG2960	long-chain fatty acid transporting porin activity
EPC_RS02530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPC_RS02535	COG3384	dioxygenase
EPC_RS02540	COG0754	glutathionylspermidine amidase activity
EPC_RS02545	COG5463	Belongs to the UPF0441 family
EPC_RS02550	COG1538	Outer membrane efflux protein
EPC_RS02555	COG0494	nUDIX hydrolase
EPC_RS02560	COG3151	Protein conserved in bacteria
EPC_RS02565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EPC_RS02570	COG3150	esterase
EPC_RS02585	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EPC_RS02605	COG2132	Multicopper oxidase
EPC_RS02610	COG0656	L-ascorbic acid biosynthetic process
EPC_RS02615	COG2207	Transcriptional regulator
EPC_RS02620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPC_RS02625	COG0076	glutamate decarboxylase activity
EPC_RS02655	COG3328	transposase activity
EPC_RS02720	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EPC_RS02730	COG1309	transcriptional regulator
EPC_RS02740	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPC_RS02745	COG1027	Aspartate ammonia-lyase
EPC_RS02750	COG3030	protein affecting phage T7 exclusion by the F plasmid
EPC_RS02755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EPC_RS02760	COG0459	protein refolding
EPC_RS02770	COG1509	lysine 2,3-aminomutase activity
EPC_RS02775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPC_RS02785	COG3040	lipid binding
EPC_RS02790	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EPC_RS02795	COG3264	Mechanosensitive ion channel
EPC_RS02795	COG1511	domain protein
EPC_RS02800	COG0688	phosphatidylethanolamine metabolic process
EPC_RS02805	COG1162	GTPase activity
EPC_RS02810	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EPC_RS02845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPC_RS02845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPC_RS02850	COG0802	atpase or kinase
EPC_RS02855	COG0860	N-Acetylmuramoyl-L-alanine amidase
EPC_RS02860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPC_RS02865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EPC_RS02875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPC_RS02880	COG0330	HflC and HflK could
EPC_RS02885	COG0330	HflC and HflK could
EPC_RS02895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPC_RS02900	COG0557	exoribonuclease II activity
EPC_RS02905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPC_RS02915	COG0840	transmembrane signaling receptor activity
EPC_RS02920	COG1073	alpha beta
EPC_RS02925	COG0360	Binds together with S18 to 16S ribosomal RNA
EPC_RS02930	COG2965	DNA replication, synthesis of RNA primer
EPC_RS02935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EPC_RS02940	COG0359	binds to the 23S rRNA
EPC_RS02945	COG3061	Opacity-associated protein A
EPC_RS02950	COG0545	Peptidyl-prolyl cis-trans isomerase
EPC_RS02960	COG0737	Belongs to the 5'-nucleotidase family
EPC_RS02965	COG1218	3'(2'),5'-bisphosphate nucleotidase
EPC_RS02975	COG1253	flavin adenine dinucleotide binding
EPC_RS02980	COG0729	surface antigen
EPC_RS02985	COG2911	Protein conserved in bacteria
EPC_RS02990	COG2105	PFAM AIG2 family protein
EPC_RS03000	COG0840	transmembrane signaling receptor activity
EPC_RS03010	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EPC_RS03015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPC_RS03020	COG3028	Belongs to the UPF0307 family
EPC_RS03025	COG0312	modulator of DNA gyrase
EPC_RS03060	COG3964	amidohydrolase
EPC_RS03075	COG3711	transcriptional antiterminator
EPC_RS03075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPC_RS03080	COG2823	Periplasmic or secreted lipoprotein
EPC_RS03085	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPC_RS03090	COG0792	nuclease activity
EPC_RS03095	COG3107	peptidoglycan biosynthetic process
EPC_RS03100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EPC_RS03110	COG1741	Belongs to the pirin family
EPC_RS03115	COG0583	DNA-binding transcription factor activity
EPC_RS03125	COG2259	Doxx family
EPC_RS03135	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
EPC_RS03140	COG4575	ribosome binding
EPC_RS03145	COG1422	Protein of unknown function (DUF1090)
EPC_RS03155	COG0586	Pfam SNARE associated Golgi protein
EPC_RS03165	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EPC_RS03175	COG0038	chloride channel
EPC_RS03180	COG1451	nucleotide metabolic process
EPC_RS03185	COG2813	Specifically methylates the guanine in position
EPC_RS03190	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPC_RS03190	COG1902	pentaerythritol trinitrate reductase activity
EPC_RS03195	COG0288	reversible hydration of carbon dioxide
EPC_RS03200	COG0659	secondary active sulfate transmembrane transporter activity
EPC_RS03215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EPC_RS03220	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
EPC_RS03230	COG0535	radical SAM domain protein
EPC_RS03255	COG3731	PTS system glucitol sorbitol-specific IIA component
EPC_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
EPC_RS03265	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPC_RS03270	COG1349	DNA-binding transcription factor activity
EPC_RS03275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPC_RS03275	COG0517	IMP dehydrogenase activity
EPC_RS03280	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EPC_RS03285	COG0732	type I restriction modification DNA specificity domain
EPC_RS03290	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EPC_RS03310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPC_RS03325	COG2801	Transposase and inactivated derivatives
EPC_RS03370	COG0477	Major facilitator Superfamily
EPC_RS03375	COG1609	Transcriptional regulator
EPC_RS03400	COG2814	Major facilitator Superfamily
EPC_RS03405	COG3706	GGDEF domain
EPC_RS03425	COG2813	Specifically methylates the guanine in position
EPC_RS03430	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
EPC_RS03435	COG0456	acetyltransferase
EPC_RS03440	COG1011	Hydrolase
EPC_RS03640	COG1397	ADP-ribosylglycohydrolase
EPC_RS03645	COG2818	Glycosylase
EPC_RS03650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EPC_RS03655	COG2823	Periplasmic or secreted lipoprotein
EPC_RS03660	COG4667	esterase of the alpha-beta hydrolase superfamily
EPC_RS03665	COG0084	hydrolase, TatD family'
EPC_RS03670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EPC_RS03675	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EPC_RS03680	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EPC_RS03685	COG0813	purine-nucleoside phosphorylase activity
EPC_RS03690	COG3550	peptidyl-serine autophosphorylation
EPC_RS03695	COG3726	membrane protein affecting hemolysin expression
EPC_RS03700	COG0560	Phosphoserine phosphatase
EPC_RS03725	COG0604	alcohol dehydrogenase
EPC_RS03735	COG0488	(ABC) transporter
EPC_RS03750	COG1349	DNA-binding transcription factor activity
EPC_RS03760	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EPC_RS03765	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EPC_RS03770	COG0406	alpha-ribazole phosphatase activity
EPC_RS03780	COG3708	Transcriptional regulator
EPC_RS03780	COG2207	Transcriptional regulator
EPC_RS03785	COG3045	CreA protein
EPC_RS03790	COG0745	RESPONSE REGULATOR receiver
EPC_RS03795	COG0460	homoserine dehydrogenase
EPC_RS03795	COG0527	aspartate kinase activity
EPC_RS03800	COG0083	homoserine kinase activity
EPC_RS03810	COG3022	response to hydroperoxide
EPC_RS03815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPC_RS03820	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPC_RS03835	COG0443	Heat shock 70 kDa protein
EPC_RS03840	COG0484	heat shock protein binding
EPC_RS03845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPC_RS03850	COG0268	Binds directly to 16S ribosomal RNA
EPC_RS03855	COG0196	riboflavin kinase activity
EPC_RS03860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPC_RS03865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EPC_RS03870	COG1047	Peptidyl-prolyl cis-trans
EPC_RS03875	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPC_RS03880	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EPC_RS03885	COG0505	Belongs to the CarA family
EPC_RS03895	COG1280	lysine exporter protein (LysE YggA)
EPC_RS03900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPC_RS03905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPC_RS03910	COG2967	ApaG domain
EPC_RS03915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPC_RS03920	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPC_RS03940	COG0564	pseudouridine synthase activity
EPC_RS03945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPC_RS03950	COG0417	DNA replication proofreading
EPC_RS03955	COG0586	Pfam SNARE associated Golgi protein
EPC_RS03960	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EPC_RS03965	COG1178	ABC-type Fe3 transport system permease component
EPC_RS03970	COG4143	(ABC) transporter
EPC_RS03985	COG2814	Major facilitator Superfamily
EPC_RS03990	COG0066	3-isopropylmalate dehydratase activity
EPC_RS03995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EPC_RS04000	COG0473	3-isopropylmalate dehydrogenase activity
EPC_RS04005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPC_RS04010	COG0028	Belongs to the TPP enzyme family
EPC_RS04025	COG2001	Belongs to the MraZ family
EPC_RS04030	COG0275	rRNA processing
EPC_RS04035	COG3116	cell division
EPC_RS04040	COG0768	penicillin binding
EPC_RS04050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPC_RS04055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPC_RS04065	COG0772	Belongs to the SEDS family
EPC_RS04070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPC_RS04080	COG1181	Belongs to the D-alanine--D-alanine ligase family
EPC_RS04090	COG0849	cell division
EPC_RS04095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPC_RS04100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EPC_RS04115	COG0653	protein targeting
EPC_RS04125	COG2801	Transposase and inactivated derivatives
EPC_RS04130	COG2963	transposase activity
EPC_RS04140	COG3397	chitin binding
EPC_RS04215	COG0494	nUDIX hydrolase
EPC_RS04220	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EPC_RS04225	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EPC_RS04235	COG0516	GMP reductase activity
EPC_RS04240	COG1459	type II secretion system
EPC_RS04245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPC_RS04250	COG4969	Belongs to the N-Me-Phe pilin family
EPC_RS04265	COG3725	Membrane protein required for beta-lactamase induction
EPC_RS04280	COG3940	Belongs to the glycosyl hydrolase 43 family
EPC_RS04285	COG2211	Major facilitator Superfamily
EPC_RS04290	COG1113	amino acid transport
EPC_RS04295	COG2186	Transcriptional regulator
EPC_RS04300	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EPC_RS04305	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPC_RS04310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPC_RS04320	COG1122	ATPase activity
EPC_RS04325	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EPC_RS04330	COG1268	BioY protein
EPC_RS04345	COG0318	PFAM AMP-dependent synthetase and ligase
EPC_RS04350	COG0183	Belongs to the thiolase family
EPC_RS04355	COG1024	Enoyl-CoA hydratase
EPC_RS04365	COG3668	Plasmid stabilization system
EPC_RS04380	COG1203	CRISPR-associated helicase, Cas3
EPC_RS04395	COG1857	crispr-associated protein
EPC_RS04410	COG1518	maintenance of DNA repeat elements
EPC_RS04415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPC_RS04435	COG3112	Uncharacterised protein family (UPF0231)
EPC_RS04440	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EPC_RS04445	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EPC_RS04455	COG2132	Multicopper oxidase
EPC_RS04465	COG1518	maintenance of DNA repeat elements
EPC_RS04470	COG1203	CRISPR-associated helicase, Cas3
EPC_RS04515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EPC_RS04520	COG0288	reversible hydration of carbon dioxide
EPC_RS04525	COG1131	(ABC) transporter
EPC_RS04530	COG0842	Transport permease protein
EPC_RS04535	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EPC_RS04540	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EPC_RS04545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EPC_RS04550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPC_RS04570	COG1489	DNA binding
EPC_RS04575	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EPC_RS04580	COG1643	Atp-dependent helicase
EPC_RS04585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPC_RS04610	COG4774	siderophore transport
EPC_RS04615	COG1120	ATPase activity
EPC_RS04620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPC_RS04625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPC_RS04630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPC_RS04635	COG0316	Belongs to the HesB IscA family
EPC_RS04650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPC_RS04655	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EPC_RS04660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPC_RS04670	COG2171	N-acyltransferase activity
EPC_RS04675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EPC_RS04685	COG0052	Belongs to the universal ribosomal protein uS2 family
EPC_RS04690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EPC_RS04695	COG0528	UMP kinase activity
EPC_RS04700	COG0233	cytoplasmic translational termination
EPC_RS04705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EPC_RS04710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPC_RS04715	COG0575	Belongs to the CDS family
EPC_RS04725	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPC_RS04730	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EPC_RS04735	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPC_RS04740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPC_RS04745	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPC_RS04750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPC_RS04755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPC_RS04765	COG0825	malonyl-CoA metabolic process
EPC_RS04770	COG1982	Orn Lys Arg decarboxylase major
EPC_RS04775	COG0346	lactoylglutathione lyase activity
EPC_RS04780	COG0037	tRNA processing
EPC_RS04790	COG4568	rho-dependent transcription termination
EPC_RS04810	COG0442	prolyl-tRNA aminoacylation
EPC_RS04815	COG1720	tRNA m6t6A37 methyltransferase activity
EPC_RS04825	COG1464	Belongs to the NlpA lipoprotein family
EPC_RS04830	COG2011	ABC-type metal ion transport system permease component
EPC_RS04840	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPC_RS04865	COG0477	Major facilitator Superfamily
EPC_RS04870	COG5544	Lipoprotein
EPC_RS04875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPC_RS04880	COG0045	succinate-CoA ligase (ADP-forming) activity
EPC_RS04880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPC_RS04880	COG1042	CoA-binding domain protein
EPC_RS04885	COG3148	PFAM DTW domain containing protein
EPC_RS04890	COG3118	belongs to the thioredoxin family
EPC_RS04895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPC_RS04900	COG2814	Major facilitator Superfamily
EPC_RS04905	COG1566	PFAM secretion protein HlyD family protein
EPC_RS04910	COG1846	Transcriptional regulator
EPC_RS04915	COG2814	Major facilitator Superfamily
EPC_RS04920	COG2113	Glycine betaine
EPC_RS04925	COG4176	ABC-type proline glycine betaine transport system permease component
EPC_RS04940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPC_RS04950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPC_RS04980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPC_RS05010	COG0745	RESPONSE REGULATOR receiver
EPC_RS05020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPC_RS05025	COG1677	Flagellar hook-basal body complex protein FliE
EPC_RS05040	COG1317	bacterial-type flagellum organization
EPC_RS05060	COG1580	Controls the rotational direction of flagella during chemotaxis
EPC_RS05070	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPC_RS05085	COG1987	bacterial-type flagellum assembly
EPC_RS05140	COG3418	PFAM FlgN family protein
EPC_RS05155	COG1815	bacterial-type flagellum-dependent cell motility
EPC_RS05185	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPC_RS05195	COG3951	Flagellar rod assembly protein muramidase FlgJ
EPC_RS05195	COG1705	Flagellar rod assembly protein muramidase FlgJ
EPC_RS05205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPC_RS05210	COG0840	transmembrane signaling receptor activity
EPC_RS05240	COG0643	Histidine kinase
EPC_RS05240	COG2198	Histidine kinase
EPC_RS05245	COG0835	chemotaxis
EPC_RS05265	COG2085	NADP oxidoreductase coenzyme F420-dependent
EPC_RS05295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EPC_RS05300	COG2867	negative regulation of translational initiation
EPC_RS05305	COG2914	Belongs to the UPF0125 (RnfH) family
EPC_RS05310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPC_RS05315	COG0497	DNA recombination
EPC_RS05320	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPC_RS05325	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EPC_RS05330	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EPC_RS05340	COG0513	Belongs to the DEAD box helicase family
EPC_RS05345	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EPC_RS05350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EPC_RS05365	COG3026	antisigma factor binding
EPC_RS05370	COG3086	response to oxidative stress
EPC_RS05375	COG0484	heat shock protein binding
EPC_RS05385	COG0481	GTPase activity
EPC_RS05395	COG0571	ribonuclease III activity
EPC_RS05405	COG1381	Involved in DNA repair and RecF pathway recombination
EPC_RS05410	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPC_RS05415	COG0736	holo-[acyl-carrier-protein] synthase activity
EPC_RS05425	COG1737	Transcriptional regulator
EPC_RS05430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPC_RS05435	COG0560	Phosphoserine phosphatase
EPC_RS05445	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EPC_RS05450	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPC_RS05450	COG0047	phosphoribosylformylglycinamidine synthase activity
EPC_RS05460	COG2205	protein histidine kinase activity
EPC_RS05465	COG3170	Tfp pilus assembly protein FimV
EPC_RS05470	COG2204	response regulator
EPC_RS05475	COG0347	Belongs to the P(II) protein family
EPC_RS05485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPC_RS05490	COG3711	transcriptional antiterminator
EPC_RS05500	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EPC_RS05505	COG0483	inositol monophosphate 1-phosphatase activity
EPC_RS05515	COG1959	2 iron, 2 sulfur cluster binding
EPC_RS05520	COG1104	cysteine desulfurase activity
EPC_RS05525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPC_RS05535	COG0531	amino acid
EPC_RS05540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPC_RS05550	COG3938	Belongs to the proline racemase family
EPC_RS05555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPC_RS05565	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPC_RS05570	COG1012	belongs to the aldehyde dehydrogenase family
EPC_RS05580	COG2897	thiosulfate sulfurtransferase activity
EPC_RS05585	COG0105	UTP biosynthetic process
EPC_RS05590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EPC_RS05600	COG1426	Protein conserved in bacteria
EPC_RS05605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EPC_RS05610	COG0124	histidyl-tRNA synthetase
EPC_RS05615	COG2976	Protein conserved in bacteria
EPC_RS05620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPC_RS05625	COG1160	GTP binding
EPC_RS05635	COG4993	Dehydrogenase
EPC_RS05650	COG1570	exodeoxyribonuclease VII activity
EPC_RS05655	COG0517	IMP dehydrogenase activity
EPC_RS05655	COG0516	GMP reductase activity
EPC_RS05665	COG0582	viral genome integration into host DNA
EPC_RS05710	COG2963	transposase activity
EPC_RS05715	COG2801	Transposase and inactivated derivatives
EPC_RS05725	COG3328	transposase activity
EPC_RS05735	COG3122	Protein conserved in bacteria
EPC_RS05750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPC_RS05755	COG2271	Major facilitator Superfamily
EPC_RS05760	COG2239	Acts as a magnesium transporter
EPC_RS05765	COG2200	EAL domain
EPC_RS05770	COG0500	methyltransferase
EPC_RS05780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPC_RS05785	COG0573	inorganic phosphate transmembrane transporter activity
EPC_RS05795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPC_RS05800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPC_RS05805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EPC_RS05815	COG2233	PERMEase
EPC_RS05820	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPC_RS05825	COG1393	Belongs to the ArsC family
EPC_RS05830	COG4783	chaperone-mediated protein folding
EPC_RS05840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPC_RS05845	COG2716	regulation of RNA biosynthetic process
EPC_RS05850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPC_RS05855	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EPC_RS05860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPC_RS05865	COG2321	neutral zinc metallopeptidase
EPC_RS05870	COG1444	tRNA N-acetyltransferase activity
EPC_RS05885	COG2963	transposase activity
EPC_RS05890	COG2801	Transposase and inactivated derivatives
EPC_RS05895	COG4974	Belongs to the 'phage' integrase family
EPC_RS05900	COG0358	DNA primase activity
EPC_RS05905	COG1396	sequence-specific DNA binding
EPC_RS05940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPC_RS05945	COG1393	Belongs to the ArsC family
EPC_RS05960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPC_RS05965	COG2197	response regulator
EPC_RS05970	COG3850	Histidine kinase
EPC_RS05985	COG0494	nUDIX hydrolase
EPC_RS05990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPC_RS05995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPC_RS06000	COG0408	coproporphyrinogen oxidase activity
EPC_RS06005	COG0860	N-Acetylmuramoyl-L-alanine amidase
EPC_RS06030	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EPC_RS06035	COG4208	sulfate ABC transporter
EPC_RS06050	COG0745	RESPONSE REGULATOR receiver
EPC_RS06055	COG2205	protein histidine kinase activity
EPC_RS06065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPC_RS06080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPC_RS06085	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EPC_RS06090	COG3115	cell septum assembly
EPC_RS06095	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPC_RS06100	COG3530	Putative quorum-sensing-regulated virulence factor
EPC_RS06105	COG0385	Bile acid
EPC_RS06110	COG0583	DNA-binding transcription factor activity
EPC_RS06140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPC_RS06145	COG3415	Transposase
EPC_RS06150	COG2116	formate transmembrane transporter activity
EPC_RS06165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPC_RS06170	COG1914	H( )-stimulated, divalent metal cation uptake system
EPC_RS06180	COG0667	Aldo Keto reductase
EPC_RS06185	COG3961	Belongs to the TPP enzyme family
EPC_RS06190	COG0837	glucose binding
EPC_RS06195	COG3279	Response regulator of the LytR AlgR family
EPC_RS06200	COG0436	Aminotransferase
EPC_RS06230	COG0668	transmembrane transport
EPC_RS06245	COG2801	Transposase and inactivated derivatives
EPC_RS06260	COG2801	Transposase and inactivated derivatives
EPC_RS06300	COG2801	Transposase and inactivated derivatives
EPC_RS06315	COG3328	transposase activity
EPC_RS06325	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPC_RS06330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPC_RS06335	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPC_RS06340	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EPC_RS06345	COG1138	Cytochrome C-type biogenesis protein
EPC_RS06355	COG4235	cytochrome complex assembly
EPC_RS06355	COG3088	subunit of a heme lyase
EPC_RS06360	COG4235	cytochrome complex assembly
EPC_RS06360	COG3088	subunit of a heme lyase
EPC_RS06370	COG2067	long-chain fatty acid transport protein
EPC_RS06375	COG0183	Belongs to the thiolase family
EPC_RS06380	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPC_RS06380	COG1024	Enoyl-CoA hydratase
EPC_RS06385	COG2062	phosphohistidine phosphatase, SixA
EPC_RS06390	COG2840	Smr protein MutS2
EPC_RS06400	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EPC_RS06410	COG0730	response to heat
EPC_RS06415	COG3101	peptidyl-lysine hydroxylation
EPC_RS06445	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPC_RS06485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPC_RS06495	COG0586	Pfam SNARE associated Golgi protein
EPC_RS06505	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPC_RS06510	COG0285	dihydrofolate synthase activity
EPC_RS06515	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EPC_RS06520	COG1286	toxin biosynthetic process
EPC_RS06525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EPC_RS06530	COG0163	prenyltransferase activity
EPC_RS06545	COG4160	amino acid transport
EPC_RS06550	COG4598	ABC transporter
EPC_RS06555	COG1090	epimerase
EPC_RS06570	COG1177	transmembrane transport
EPC_RS06575	COG1176	ABC-type spermidine putrescine transport system, permease component I
EPC_RS06585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPC_RS06595	COG3842	ATPase activity
EPC_RS06600	COG0280	phosphate acetyltransferase
EPC_RS06600	COG0857	belongs to the CobB CobQ family
EPC_RS06605	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPC_RS06615	COG3092	negative regulation of chromosome organization
EPC_RS06620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPC_RS06640	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EPC_RS06645	COG0436	Aminotransferase
EPC_RS06650	COG0583	DNA-binding transcription factor activity
EPC_RS06655	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPC_RS06660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPC_RS06665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPC_RS06665	COG0649	NAD binding
EPC_RS06675	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EPC_RS06685	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EPC_RS06690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPC_RS06695	COG0839	Belongs to the complex I subunit 6 family
EPC_RS06700	COG0713	ATP synthesis coupled electron transport
EPC_RS06705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPC_RS06710	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EPC_RS06715	COG1007	ATP synthesis coupled electron transport
EPC_RS06720	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EPC_RS06725	COG4575	ribosome binding
EPC_RS06755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPC_RS06765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPC_RS06770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPC_RS06785	COG2205	protein histidine kinase activity
EPC_RS06785	COG0784	Response regulator, receiver
EPC_RS06790	COG2197	response regulator
EPC_RS06795	COG2198	Histidine kinase
EPC_RS06795	COG0642	Histidine kinase
EPC_RS06825	COG1126	abc transporter atp-binding protein
EPC_RS06840	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EPC_RS06845	COG1473	amidohydrolase
EPC_RS06850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPC_RS06935	COG3083	sulfuric ester hydrolase activity
EPC_RS06940	COG3082	Protein of unknown function (DUF1414)
EPC_RS06945	COG3081	Nucleoid-associated protein
EPC_RS06950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EPC_RS06955	COG1061	Type III restriction enzyme res subunit
EPC_RS06960	COG1187	pseudouridine synthase activity
EPC_RS06965	COG2814	Major facilitator Superfamily
EPC_RS06975	COG4172	Belongs to the ABC transporter superfamily
EPC_RS06980	COG4239	(ABC) transporter, permease
EPC_RS06985	COG4174	ABC transporter (Permease)
EPC_RS06990	COG4166	transmembrane transport
EPC_RS06995	COG2200	EAL domain
EPC_RS07000	COG0791	NLP P60 protein
EPC_RS07005	COG0671	phosphoesterase, PA-phosphatase related
EPC_RS07010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPC_RS07020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPC_RS07020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPC_RS07025	COG1105	Belongs to the carbohydrate kinase PfkB family
EPC_RS07030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPC_RS07030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPC_RS07030	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EPC_RS07035	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EPC_RS07045	COG0583	DNA-binding transcription factor activity
EPC_RS07050	COG0833	amino acid
EPC_RS07055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPC_RS07060	COG1120	ATPase activity
EPC_RS07075	COG0583	DNA-binding transcription factor activity
EPC_RS07080	COG0302	gtp cyclohydrolase
EPC_RS07085	COG2311	Membrane
EPC_RS07100	COG2949	membrane
EPC_RS07105	COG0281	malic enzyme
EPC_RS07110	COG0295	cytidine deaminase activity
EPC_RS07115	COG1346	cytolysis
EPC_RS07120	COG1380	Effector of murein hydrolase LrgA
EPC_RS07125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPC_RS07125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPC_RS07130	COG0489	protein tyrosine kinase activity
EPC_RS07145	COG1605	Chorismate mutase
EPC_RS07155	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EPC_RS07160	COG0351	phosphomethylpyrimidine kinase
EPC_RS07165	COG1597	lipid kinase activity
EPC_RS07180	COG0745	RESPONSE REGULATOR receiver
EPC_RS07185	COG2205	protein histidine kinase activity
EPC_RS07205	COG0667	Aldo Keto reductase
EPC_RS07210	COG0443	Heat shock 70 kDa protein
EPC_RS07220	COG0572	uridine kinase
EPC_RS07225	COG0717	Belongs to the dCTP deaminase family
EPC_RS07230	COG2982	Protein involved in outer membrane biogenesis
EPC_RS07235	COG1253	flavin adenine dinucleotide binding
EPC_RS07300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EPC_RS07335	COG1442	glycosyl transferase family 8
EPC_RS07375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EPC_RS07380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPC_RS07380	COG0140	phosphoribosyl-ATP diphosphatase activity
EPC_RS07390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EPC_RS07400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPC_RS07400	COG0131	Imidazoleglycerol-phosphate dehydratase
EPC_RS07405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EPC_RS07415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EPC_RS07420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPC_RS07430	COG2925	Exonuclease
EPC_RS07440	COG1289	transmembrane transporter activity
EPC_RS07445	COG2926	Belongs to the UPF0265 family
EPC_RS07450	COG0534	Mate efflux family protein
EPC_RS07460	COG1280	lysine exporter protein (LysE YggA)
EPC_RS07465	COG2423	ornithine cyclodeaminase activity
EPC_RS07475	COG0077	Prephenate dehydratase
EPC_RS07480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPC_RS07500	COG1522	sequence-specific DNA binding
EPC_RS07510	COG3284	Transcriptional regulator
EPC_RS07515	COG1063	alcohol dehydrogenase
EPC_RS07520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPC_RS07540	COG2801	Transposase and inactivated derivatives
EPC_RS07550	COG1204	response to ionizing radiation
EPC_RS07585	COG2801	Transposase and inactivated derivatives
EPC_RS07595	COG0582	viral genome integration into host DNA
EPC_RS07620	COG0583	DNA-binding transcription factor activity
EPC_RS07625	COG1280	lysine exporter protein (LysE YggA)
EPC_RS07640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPC_RS07670	COG0747	negative chemotaxis
EPC_RS07675	COG0601	transmembrane transport
EPC_RS07680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPC_RS07685	COG4172	Belongs to the ABC transporter superfamily
EPC_RS07700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPC_RS07705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPC_RS07710	COG1121	(ABC) transporter
EPC_RS07720	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EPC_RS07730	COG3228	Belongs to the MtfA family
EPC_RS07740	COG1418	mRNA catabolic process
EPC_RS07745	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPC_RS07755	COG3727	T/G mismatch-specific endonuclease activity
EPC_RS07760	COG0697	spore germination
EPC_RS07770	COG2354	Protein conserved in bacteria
EPC_RS07775	COG5475	Uncharacterized small protein (DUF2158)
EPC_RS07790	COG0366	Alpha amylase catalytic
EPC_RS07800	COG1516	flagellar protein fliS
EPC_RS07805	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPC_RS07810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPC_RS07810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPC_RS07835	COG0506	proline dehydrogenase activity
EPC_RS07835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EPC_RS07835	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EPC_RS07840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPC_RS07860	COG1702	phosphate starvation-inducible protein PhoH
EPC_RS07865	COG0778	Nitroreductase
EPC_RS07875	COG1785	Belongs to the alkaline phosphatase family
EPC_RS07900	COG3381	protein complex oligomerization
EPC_RS07905	COG0697	spore germination
EPC_RS07915	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EPC_RS07930	COG0431	NADPH-dependent FMN reductase
EPC_RS07935	COG0113	porphobilinogen synthase activity
EPC_RS08000	COG0835	chemotaxis
EPC_RS08010	COG0840	transmembrane signaling receptor activity
EPC_RS08020	COG0840	transmembrane signaling receptor activity
EPC_RS08025	COG0840	transmembrane signaling receptor activity
EPC_RS08030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPC_RS08040	COG0745	RESPONSE REGULATOR receiver
EPC_RS08050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EPC_RS08065	COG0018	arginyl-trna synthetase
EPC_RS08070	COG3102	Protein conserved in bacteria
EPC_RS08075	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EPC_RS08080	COG3142	Participates in the control of copper homeostasis
EPC_RS08095	COG0500	methyltransferase
EPC_RS08100	COG2226	methyltransferase
EPC_RS08105	COG3788	relative of glutathione S-transferase, MAPEG superfamily
EPC_RS08110	COG1801	Protein of unknown function DUF72
EPC_RS08115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EPC_RS08120	COG0494	nUDIX hydrolase
EPC_RS08125	COG0217	transcriptional regulatory protein
EPC_RS08130	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EPC_RS08135	COG0632	four-way junction helicase activity
EPC_RS08140	COG2255	four-way junction helicase activity
EPC_RS08145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPC_RS08155	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EPC_RS08160	COG0739	heme binding
EPC_RS08165	COG1560	Kdo2-lipid A biosynthetic process
EPC_RS08175	COG0469	pyruvate kinase activity
EPC_RS08180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EPC_RS08185	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EPC_RS08190	COG3141	response to X-ray
EPC_RS08200	COG1770	oligopeptidase
EPC_RS08205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPC_RS08245	COG0628	permease
EPC_RS08260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPC_RS08260	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EPC_RS08265	COG3008	intermembrane lipid transfer
EPC_RS08270	COG2995	paraquat-inducible protein a
EPC_RS08275	COG1956	GAF domain-containing protein
EPC_RS08280	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EPC_RS08290	COG0501	Belongs to the peptidase M48B family
EPC_RS08315	COG2226	methyltransferase
EPC_RS08320	COG1253	flavin adenine dinucleotide binding
EPC_RS08325	COG1760	l-serine dehydratase
EPC_RS08340	COG3140	Belongs to the UPF0181 family
EPC_RS08345	COG0251	oxidation-reduction process
EPC_RS08350	COG1199	ATP-dependent helicase activity
EPC_RS08360	COG3065	identical protein binding
EPC_RS08365	COG0318	PFAM AMP-dependent synthetase and ligase
EPC_RS08375	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EPC_RS08380	COG2894	cell division
EPC_RS08385	COG0850	regulation of cytokinetic process
EPC_RS08390	COG3100	YcgL domain-containing protein
EPC_RS08395	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPC_RS08410	COG2186	Transcriptional regulator
EPC_RS08415	COG2719	SpoVR family
EPC_RS08420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPC_RS08425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPC_RS08445	COG2718	Belongs to the UPF0229 family
EPC_RS08450	COG2766	serine protein kinase
EPC_RS08455	COG3713	MltA-interacting MipA family protein
EPC_RS08460	COG0656	L-ascorbic acid biosynthetic process
EPC_RS08475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPC_RS08480	COG3139	Protein of unknown function (DUF1315)
EPC_RS08485	COG1335	isochorismatase
EPC_RS08490	COG0252	asparaginase activity
EPC_RS08495	COG0616	signal peptide processing
EPC_RS08500	COG0778	Nitroreductase
EPC_RS08505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPC_RS08515	COG0708	Exodeoxyribonuclease III
EPC_RS08525	COG0788	formyltetrahydrofolate deformylase activity
EPC_RS08530	COG3012	SEC-C Motif Domain Protein
EPC_RS08540	COG0745	RESPONSE REGULATOR receiver
EPC_RS08545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EPC_RS08575	COG2095	MarC family integral membrane protein
EPC_RS08585	COG4166	transmembrane transport
EPC_RS08595	COG0601	transmembrane transport
EPC_RS08600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPC_RS08605	COG0444	Belongs to the ABC transporter superfamily
EPC_RS08610	COG4608	Belongs to the ABC transporter superfamily
EPC_RS08615	COG3099	Belongs to the UPF0263 family
EPC_RS08620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPC_RS08625	COG2350	Protein conserved in bacteria
EPC_RS08640	COG2917	probably involved in intracellular septation
EPC_RS08650	COG3047	cAMP biosynthetic process
EPC_RS08660	COG0159	tryptophan synthase activity
EPC_RS08665	COG0133	tryptophan synthase activity
EPC_RS08675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPC_RS08680	COG0512	Glutamine amidotransferase of anthranilate synthase
EPC_RS08680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPC_RS08690	COG0613	PHP domain protein
EPC_RS08695	COG0009	L-threonylcarbamoyladenylate synthase
EPC_RS08710	COG1028	Short-chain dehydrogenase reductase Sdr
EPC_RS08715	COG0616	signal peptide processing
EPC_RS08740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EPC_RS08750	COG0671	phosphoesterase, PA-phosphatase related
EPC_RS08755	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EPC_RS08760	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EPC_RS08765	COG0284	orotidine-5'-phosphate decarboxylase activity
EPC_RS08770	COG0023	Translation Initiation Factor
EPC_RS08785	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EPC_RS08805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPC_RS08805	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPC_RS08810	COG4172	Belongs to the ABC transporter superfamily
EPC_RS08815	COG4172	Belongs to the ABC transporter superfamily
EPC_RS08820	COG4171	peptide transport system, permease
EPC_RS08825	COG4168	peptide transport system, permease
EPC_RS08830	COG4166	transmembrane transport
EPC_RS08840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EPC_RS08845	COG1842	Phage shock protein A
EPC_RS08855	COG1983	PspC domain protein
EPC_RS08865	COG3106	COG3106 Predicted ATPase
EPC_RS08870	COG3768	UPF0283 membrane protein
EPC_RS08885	COG4948	Mandelate Racemase Muconate Lactonizing
EPC_RS08890	COG4166	transmembrane transport
EPC_RS08895	COG2046	Belongs to the sulfate adenylyltransferase family
EPC_RS08895	COG0529	Catalyzes the synthesis of activated sulfate
EPC_RS08910	COG3188	usher protein
EPC_RS08915	COG3121	Chaperone
EPC_RS08930	COG0366	Alpha amylase catalytic
EPC_RS08935	COG0037	tRNA processing
EPC_RS08940	COG0513	Belongs to the DEAD box helicase family
EPC_RS08950	COG3042	response to heat
EPC_RS08955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPC_RS08960	COG2911	Protein conserved in bacteria
EPC_RS08970	COG3784	Protein of unknown function (DUF1318)
EPC_RS08985	COG1643	Atp-dependent helicase
EPC_RS08990	COG3023	N-Acetylmuramoyl-L-alanine amidase
EPC_RS08995	COG3591	Belongs to the peptidase S1B family
EPC_RS09005	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EPC_RS09010	COG2205	protein histidine kinase activity
EPC_RS09035	COG1396	sequence-specific DNA binding
EPC_RS09090	COG3179	chitinase
EPC_RS09190	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPC_RS09210	COG0745	RESPONSE REGULATOR receiver
EPC_RS09220	COG0531	amino acid
EPC_RS09230	COG3182	Iron-regulated membrane protein
EPC_RS09250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPC_RS09255	COG1621	beta-fructofuranosidase activity
EPC_RS09295	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPC_RS09300	COG0747	negative chemotaxis
EPC_RS09305	COG2814	Major facilitator Superfamily
EPC_RS09315	COG2207	Transcriptional regulator
EPC_RS09315	COG3708	Transcriptional regulator
EPC_RS09330	COG4290	ribonuclease
EPC_RS09375	COG0840	transmembrane signaling receptor activity
EPC_RS09380	COG2801	Transposase and inactivated derivatives
EPC_RS09435	COG4771	TonB-dependent receptor
EPC_RS09435	COG4771	TonB-dependent receptor
EPC_RS09435	COG1629	transport
EPC_RS09435	COG1629	transport
EPC_RS09445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EPC_RS09450	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPC_RS09455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPC_RS09465	COG2707	UPF0756 membrane protein
EPC_RS09485	COG0339	signal peptide processing
EPC_RS09490	COG0402	S-adenosylhomocysteine deaminase activity
EPC_RS09495	COG4221	oxidoreductase activity
EPC_RS09510	COG0477	Major facilitator Superfamily
EPC_RS09520	COG1940	carbohydrate kinase activity
EPC_RS09525	COG0583	DNA-binding transcription factor activity
EPC_RS09530	COG2814	Major facilitator Superfamily
EPC_RS09550	COG5339	Protein conserved in bacteria
EPC_RS09555	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPC_RS09560	COG0673	inositol 2-dehydrogenase activity
EPC_RS09570	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPC_RS09580	COG1879	ABC-type sugar transport system periplasmic component
EPC_RS09585	COG1069	ribulokinase activity
EPC_RS09590	COG2160	L-arabinose isomerase activity
EPC_RS09605	COG4657	Part of a membrane complex involved in electron transport
EPC_RS09610	COG2878	Part of a membrane complex involved in electron transport
EPC_RS09620	COG4658	electron transport chain
EPC_RS09625	COG4659	FMN binding
EPC_RS09630	COG4660	Part of a membrane complex involved in electron transport
EPC_RS09635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPC_RS09650	COG1309	transcriptional regulator
EPC_RS09665	COG0625	glutathione transferase activity
EPC_RS09675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPC_RS09680	COG0259	pyridoxamine-phosphate oxidase activity
EPC_RS09685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EPC_RS09705	COG3328	transposase activity
EPC_RS09720	COG1309	transcriptional regulator
EPC_RS09725	COG1902	pentaerythritol trinitrate reductase activity
EPC_RS09730	COG0346	lactoylglutathione lyase activity
EPC_RS09740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EPC_RS09745	COG0791	NLP P60 protein
EPC_RS09750	COG1609	Transcriptional regulator
EPC_RS09755	COG0583	DNA-binding transcription factor activity
EPC_RS09760	COG2814	Major facilitator Superfamily
EPC_RS09765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPC_RS09770	COG0307	riboflavin synthase, alpha
EPC_RS09790	COG0469	pyruvate kinase activity
EPC_RS09810	COG0719	Fe-S assembly protein
EPC_RS09815	COG0396	ATPase activity
EPC_RS09820	COG0719	Fe-S assembly protein
EPC_RS09825	COG0316	Belongs to the HesB IscA family
EPC_RS09835	COG0277	FAD linked oxidase domain protein
EPC_RS09835	COG0247	lactate metabolic process
EPC_RS09840	COG0628	permease
EPC_RS09845	COG0574	Belongs to the PEP-utilizing enzyme family
EPC_RS09845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPC_RS09850	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EPC_RS09855	COG3720	iron ion transport
EPC_RS09860	COG4558	Periplasmic binding protein
EPC_RS09865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPC_RS09870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EPC_RS09875	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EPC_RS09880	COG0791	NLP P60 protein
EPC_RS09885	COG0386	Belongs to the glutathione peroxidase family
EPC_RS09895	COG0776	regulation of translation
EPC_RS09900	COG0072	phenylalanine-tRNA ligase activity
EPC_RS09900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPC_RS09905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EPC_RS09910	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EPC_RS09915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPC_RS09925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EPC_RS09940	COG3137	Salt-induced outer membrane protein
EPC_RS09950	COG3001	Fructosamine kinase
EPC_RS09960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPC_RS09965	COG1988	membrane-bound metal-dependent
EPC_RS09970	COG1823	symporter activity
EPC_RS09975	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPC_RS09980	COG2814	Major facilitator Superfamily
EPC_RS09985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EPC_RS09990	COG0322	excinuclease ABC activity
EPC_RS09995	COG3678	ATP-independent chaperone mediated protein folding
EPC_RS10000	COG2988	succinylglutamate desuccinylase activity
EPC_RS10005	COG3724	N-succinylarginine dihydrolase activity
EPC_RS10010	COG1012	belongs to the aldehyde dehydrogenase family
EPC_RS10015	COG3138	arginine N-succinyltransferase
EPC_RS10025	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPC_RS10030	COG4932	domain protein
EPC_RS10055	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EPC_RS10085	COG0387	Pfam Sodium calcium exchanger
EPC_RS10090	COG3187	Heat shock protein
EPC_RS10095	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPC_RS10100	COG2912	Transglutaminase-like superfamily
EPC_RS10110	COG2890	protein-(glutamine-N5) methyltransferase activity
EPC_RS10115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EPC_RS10120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EPC_RS10125	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EPC_RS10130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EPC_RS10145	COG0193	aminoacyl-tRNA hydrolase activity
EPC_RS10155	COG0659	secondary active sulfate transmembrane transporter activity
EPC_RS10160	COG0012	GTP binding
EPC_RS10315	COG2801	Transposase and inactivated derivatives
EPC_RS10335	COG3290	protein histidine kinase activity
EPC_RS10340	COG4565	transcriptional regulatory protein
EPC_RS10360	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EPC_RS10360	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EPC_RS10370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPC_RS10375	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
EPC_RS10380	COG2261	transglycosylase associated protein
EPC_RS10390	COG1619	proteins homologs of microcin C7 resistance protein MccF
EPC_RS10425	COG2801	Transposase and inactivated derivatives
EPC_RS10435	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EPC_RS10445	COG3778	Protein conserved in bacteria
EPC_RS10450	COG3299	homolog of phage Mu protein gp47
EPC_RS10490	COG4386	tail sheath protein
EPC_RS10530	COG0740	serine-type endopeptidase activity
EPC_RS10535	COG4695	Portal protein
EPC_RS10540	COG4626	Terminase
EPC_RS10540	COG1802	Transcriptional regulator
EPC_RS10605	COG1403	HNH endonuclease
EPC_RS10610	COG4725	Belongs to the MT-A70-like family
EPC_RS10620	COG4626	Terminase
EPC_RS10620	COG1802	Transcriptional regulator
EPC_RS10675	COG5532	Uncharacterized conserved protein (DUF2303)
EPC_RS10680	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EPC_RS10710	COG0582	viral genome integration into host DNA
EPC_RS10720	COG0538	isocitrate dehydrogenase activity
EPC_RS10740	COG2915	High frequency lysogenization protein hflD homolog
EPC_RS10745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPC_RS10750	COG0745	RESPONSE REGULATOR receiver
EPC_RS10760	COG2850	peptidyl-arginine hydroxylation
EPC_RS10765	COG1396	sequence-specific DNA binding
EPC_RS10770	COG3135	benzoate transporter
EPC_RS10780	COG1940	carbohydrate kinase activity
EPC_RS10785	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPC_RS10795	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPC_RS10800	COG2199	diguanylate cyclase activity
EPC_RS10815	COG0784	Response regulator, receiver
EPC_RS10815	COG0835	chemotaxis
EPC_RS10820	COG1677	Flagellar hook-basal body complex protein FliE
EPC_RS10830	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPC_RS10835	COG1317	bacterial-type flagellum organization
EPC_RS10855	COG1580	Controls the rotational direction of flagella during chemotaxis
EPC_RS10860	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPC_RS10875	COG1338	Plays a role in the flagellum-specific transport system
EPC_RS10910	COG1215	transferase activity, transferring glycosyl groups
EPC_RS10915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPC_RS10930	COG3134	Outer membrane lipoprotein
EPC_RS10935	COG1252	NADH dehydrogenase
EPC_RS10945	COG1472	Belongs to the glycosyl hydrolase 3 family
EPC_RS10955	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
EPC_RS10960	COG5633	Lipoprotein
EPC_RS10965	COG0537	adenosine 5'-monophosphoramidase activity
EPC_RS10975	COG0084	hydrolase, TatD family'
EPC_RS10980	COG0470	DNA polymerase III
EPC_RS10985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EPC_RS10990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPC_RS10995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPC_RS11000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPC_RS11005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPC_RS11015	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EPC_RS11020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPC_RS11025	COG0416	fatty acid biosynthetic process
EPC_RS11035	COG1399	metal-binding, possibly nucleic acid-binding protein
EPC_RS11040	COG0424	maF-like protein
EPC_RS11045	COG0564	pseudouridine synthase activity
EPC_RS11050	COG1530	ribonuclease E activity
EPC_RS11050	COG1530	ribonuclease E activity
EPC_RS11090	COG1749	Flagellar hook protein flgE
EPC_RS11095	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EPC_RS11100	COG1558	bacterial-type flagellum-dependent cell motility
EPC_RS11105	COG1815	bacterial-type flagellum-dependent cell motility
EPC_RS11115	COG2747	anti-sigma28 factor FlgM
EPC_RS11120	COG3418	PFAM FlgN family protein
EPC_RS11135	COG3132	Protein of unknown function, DUF480
EPC_RS11140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPC_RS11145	COG2999	glutathione oxidoreductase activity
EPC_RS11155	COG0418	dihydroorotase activity
EPC_RS11175	COG0477	Major facilitator Superfamily
EPC_RS11180	COG3038	cytochrome b561
EPC_RS11185	COG2353	YceI-like domain
EPC_RS11190	COG1054	Belongs to the UPF0176 family
EPC_RS11195	COG1560	Kdo2-lipid A biosynthetic process
EPC_RS11205	COG5645	(Lipo)protein
EPC_RS11210	COG2943	transferase activity, transferring hexosyl groups
EPC_RS11225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPC_RS11245	COG1846	Transcriptional regulator
EPC_RS11260	COG2801	Transposase and inactivated derivatives
EPC_RS11305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPC_RS11310	COG0322	excinuclease ABC activity
EPC_RS11315	COG2197	response regulator
EPC_RS11330	COG2197	response regulator
EPC_RS11335	COG1113	amino acid transport
EPC_RS11345	COG1309	transcriptional regulator
EPC_RS11350	COG0697	spore germination
EPC_RS11360	COG1012	belongs to the aldehyde dehydrogenase family
EPC_RS11385	COG3328	transposase activity
EPC_RS11390	COG0670	Belongs to the BI1 family
EPC_RS11395	COG2920	part of a sulfur-relay system
EPC_RS11405	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPC_RS11410	COG3785	DNA binding
EPC_RS11415	COG1832	CoA-binding protein
EPC_RS11425	COG1803	Methylglyoxal synthase
EPC_RS11430	COG0210	DNA helicase
EPC_RS11435	COG3304	Inner membrane component domain
EPC_RS11440	COG1289	transmembrane transporter activity
EPC_RS11445	COG3070	regulator of competence-specific genes
EPC_RS11455	COG2885	chlorophyll binding
EPC_RS11455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPC_RS11460	COG3120	sequence-specific DNA binding
EPC_RS11465	COG1067	ATP-dependent peptidase activity
EPC_RS11470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPC_RS11475	COG3009	Protein conserved in bacteria
EPC_RS11480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPC_RS11480	COG3008	intermembrane lipid transfer
EPC_RS11485	COG2995	paraquat-inducible protein a
EPC_RS11490	COG0488	(ABC) transporter
EPC_RS11495	COG0116	Belongs to the methyltransferase superfamily
EPC_RS11495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPC_RS11500	COG0633	Ferredoxin
EPC_RS11500	COG3217	Mosc domain protein beta barrel domain protein
EPC_RS11510	COG0167	dihydroorotate dehydrogenase activity
EPC_RS11515	COG0431	NADPH-dependent FMN reductase
EPC_RS11520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPC_RS11530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPC_RS11540	COG0308	aminopeptidase N
EPC_RS11545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EPC_RS11550	COG0017	Asparaginyl-tRNA synthetase
EPC_RS11560	COG1448	Aminotransferase
EPC_RS11565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPC_RS11570	COG3108	Peptidase M15
EPC_RS11575	COG2989	Protein conserved in bacteria
EPC_RS11580	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EPC_RS11585	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EPC_RS11590	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EPC_RS11595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPC_RS11600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPC_RS11605	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EPC_RS11610	COG2835	tetraacyldisaccharide 4'-kinase activity
EPC_RS11615	COG1663	tetraacyldisaccharide 4'-kinase activity
EPC_RS11625	COG2333	competence protein COMEC
EPC_RS11625	COG0658	competence protein
EPC_RS11630	COG0776	regulation of translation
EPC_RS11635	COG0539	negative regulation of cytoplasmic translation
EPC_RS11640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EPC_RS11645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EPC_RS11650	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EPC_RS11655	COG1944	ATP diphosphatase activity
EPC_RS11665	COG0477	Major facilitator Superfamily
EPC_RS11680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EPC_RS11685	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EPC_RS11690	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EPC_RS11695	COG3107	peptidoglycan biosynthetic process
EPC_RS11695	COG1674	ftsk spoiiie
EPC_RS11705	COG0492	ferredoxin-NADP+ reductase activity
EPC_RS11710	COG4988	ABC transporter
EPC_RS11715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EPC_RS11720	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EPC_RS11725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPC_RS11730	COG0542	response to heat
EPC_RS11735	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EPC_RS11740	COG1278	Cold shock
EPC_RS11745	COG3593	DNA synthesis involved in DNA repair
EPC_RS11750	COG0028	Belongs to the TPP enzyme family
EPC_RS11755	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EPC_RS11760	COG3023	N-Acetylmuramoyl-L-alanine amidase
EPC_RS11765	COG0393	Putative heavy-metal-binding
EPC_RS11775	COG1126	abc transporter atp-binding protein
EPC_RS11780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPC_RS11785	COG4215	(ABC) transporter
EPC_RS11790	COG4160	amino acid transport
EPC_RS11795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPC_RS11805	COG1177	transmembrane transport
EPC_RS11810	COG1176	ABC-type spermidine putrescine transport system, permease component I
EPC_RS11815	COG3842	ATPase activity
EPC_RS11820	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EPC_RS11845	COG0569	domain protein
EPC_RS11845	COG2985	domain, Protein
EPC_RS11860	COG0814	amino acid
EPC_RS11865	COG1686	Belongs to the peptidase S11 family
EPC_RS11885	COG4172	Belongs to the ABC transporter superfamily
EPC_RS11895	COG0303	'Molybdopterin
EPC_RS11905	COG0488	(ABC) transporter
EPC_RS11910	COG2814	Major facilitator Superfamily
EPC_RS11920	COG2814	Major facilitator Superfamily
EPC_RS11925	COG1566	PFAM secretion protein HlyD family protein
EPC_RS11930	COG1321	iron dependent repressor
EPC_RS11935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPC_RS11945	COG0783	Belongs to the Dps family
EPC_RS11950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPC_RS11955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPC_RS11960	COG0765	amino acid transport
EPC_RS11965	COG1126	abc transporter atp-binding protein
EPC_RS11980	COG0668	transmembrane transport
EPC_RS11985	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EPC_RS11995	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
EPC_RS12025	COG1228	amidohydrolase
EPC_RS12030	COG0402	S-adenosylhomocysteine deaminase activity
EPC_RS12045	COG2986	histidine ammonia-lyase
EPC_RS12050	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EPC_RS12055	COG1473	amidohydrolase
EPC_RS12060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPC_RS12080	COG0789	Transcriptional regulator
EPC_RS12090	COG4221	oxidoreductase activity
EPC_RS12105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPC_RS12125	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EPC_RS12135	COG1472	Belongs to the glycosyl hydrolase 3 family
EPC_RS12140	COG0277	FAD linked oxidase domain protein
EPC_RS12145	COG1511	domain protein
EPC_RS12145	COG3264	Mechanosensitive ion channel
EPC_RS12150	COG1686	Belongs to the peptidase S11 family
EPC_RS12165	COG0586	Pfam SNARE associated Golgi protein
EPC_RS12175	COG1376	ErfK ybiS ycfS ynhG family protein
EPC_RS12180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPC_RS12185	COG0513	Belongs to the DEAD box helicase family
EPC_RS12195	COG0670	Belongs to the BI1 family
EPC_RS12210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EPC_RS12215	COG0315	cyclic pyranopterin monophosphate synthase activity
EPC_RS12220	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPC_RS12235	COG0556	nucleotide-excision repair
EPC_RS12245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EPC_RS12255	COG0156	8-amino-7-oxononanoate synthase activity
EPC_RS12260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EPC_RS12270	COG2130	NADP-dependent
EPC_RS12275	COG1881	PFAM PEBP family protein
EPC_RS12280	COG2706	6-phosphogluconolactonase activity
EPC_RS12285	COG0561	phosphatase activity
EPC_RS12295	COG4149	molybdate abc transporter
EPC_RS12300	COG0725	ABC transporter, periplasmic molybdate-binding protein
EPC_RS12310	COG3585	molybdate ion transport
EPC_RS12310	COG2005	Transcriptional regulator
EPC_RS12320	COG1119	ATPase activity
EPC_RS12325	COG3328	transposase activity
EPC_RS12335	COG1119	ATPase activity
EPC_RS12340	COG1085	galactose-1-phosphate uridylyltransferase
EPC_RS12345	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EPC_RS12350	COG2017	converts alpha-aldose to the beta-anomer
EPC_RS12355	COG0588	phosphoglycerate mutase activity
EPC_RS12370	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPC_RS12390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EPC_RS12395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPC_RS12420	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EPC_RS12425	COG2885	chlorophyll binding
EPC_RS12430	COG0823	Involved in the tonB-independent uptake of proteins
EPC_RS12435	COG3064	Membrane
EPC_RS12440	COG0848	biopolymer transport protein
EPC_RS12445	COG0811	peptide transport
EPC_RS12450	COG0824	Thioesterase
EPC_RS12455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EPC_RS12460	COG0045	succinate-CoA ligase (ADP-forming) activity
EPC_RS12465	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPC_RS12470	COG0567	Dehydrogenase, E1 component
EPC_RS12475	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPC_RS12480	COG1053	succinate dehydrogenase
EPC_RS12485	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EPC_RS12490	COG2009	succinate dehydrogenase
EPC_RS12495	COG0372	Belongs to the citrate synthase family
EPC_RS12505	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EPC_RS12520	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EPC_RS12525	COG1984	allophanate hydrolase subunit 2
EPC_RS12530	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EPC_RS12540	COG0415	Belongs to the DNA photolyase family
EPC_RS12545	COG3272	Protein of unknown function (DUF1722)
EPC_RS12555	COG0745	RESPONSE REGULATOR receiver
EPC_RS12560	COG0033	Phosphoglucomutase
EPC_RS12565	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EPC_RS12570	COG0596	Alpha beta hydrolase
EPC_RS12585	COG0735	belongs to the Fur family
EPC_RS12590	COG0814	amino acid
EPC_RS12600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPC_RS12610	COG0363	glucosamine-6-phosphate deaminase activity
EPC_RS12615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPC_RS12620	COG1940	carbohydrate kinase activity
EPC_RS12620	COG1846	Transcriptional regulator
EPC_RS12625	COG0647	UMP catabolic process
EPC_RS12630	COG0367	asparagine synthase
EPC_RS12665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPC_RS12670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPC_RS12675	COG1702	phosphate starvation-inducible protein PhoH
EPC_RS12680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EPC_RS12685	COG4535	Mg2 and Co2 transporter CorC
EPC_RS12690	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPC_RS12700	COG0765	amino acid transport
EPC_RS12705	COG0765	amino acid transport
EPC_RS12710	COG1126	abc transporter atp-binding protein
EPC_RS12715	COG2888	peptidyl-tyrosine sulfation
EPC_RS12720	COG0495	leucyl-tRNA aminoacylation
EPC_RS12725	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EPC_RS12730	COG1466	dna polymerase III delta subunit
EPC_RS12740	COG0799	negative regulation of ribosome biogenesis
EPC_RS12745	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EPC_RS12750	COG0768	penicillin binding
EPC_RS12755	COG0772	Belongs to the SEDS family
EPC_RS12760	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPC_RS12765	COG1686	Belongs to the peptidase S11 family
EPC_RS12770	COG2921	Belongs to the UPF0250 family
EPC_RS12775	COG0321	lipoyl(octanoyl) transferase activity
EPC_RS12780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPC_RS12785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPC_RS12790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPC_RS12805	COG2610	gluconate transmembrane transporter activity
EPC_RS12810	COG3622	Belongs to the hyi family
EPC_RS12815	COG0235	Class ii aldolase
EPC_RS12820	COG3395	kinase activity
EPC_RS12825	COG2084	Dehydrogenase
EPC_RS12830	COG1349	DNA-binding transcription factor activity
EPC_RS12855	COG1271	oxidase subunit
EPC_RS12860	COG1294	oxidase, subunit
EPC_RS12870	COG2076	Multidrug Resistance protein
EPC_RS12875	COG2076	Multidrug Resistance protein
EPC_RS12880	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPC_RS12885	COG0726	polysaccharide deacetylase
EPC_RS12890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPC_RS12890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPC_RS12895	COG0463	Glycosyl transferase, family 2
EPC_RS12900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPC_RS12910	COG4993	Dehydrogenase
EPC_RS12930	COG4172	Belongs to the ABC transporter superfamily
EPC_RS12935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPC_RS12940	COG0601	transmembrane transport
EPC_RS12965	COG1764	response to oxidative stress
EPC_RS13045	COG0582	viral genome integration into host DNA
EPC_RS13050	COG0582	viral genome integration into host DNA
EPC_RS13060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPC_RS13065	COG2501	S4 domain
EPC_RS13070	COG1064	alcohol dehydrogenase
EPC_RS13075	COG0215	cysteine-tRNA ligase activity
EPC_RS13080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPC_RS13090	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPC_RS13095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPC_RS13100	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EPC_RS13105	COG4181	ATPase activity
EPC_RS13110	COG2755	lipolytic protein G-D-S-L family
EPC_RS13115	COG0300	oxidoreductase activity
EPC_RS13120	COG3118	belongs to the thioredoxin family
EPC_RS13125	COG0330	HflC and HflK could
EPC_RS13130	COG1585	Membrane protein implicated in regulation of membrane protease activity
EPC_RS13140	COG2217	Heavy metal translocating P-type atpase
EPC_RS13145	COG3735	TraB family
EPC_RS13150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EPC_RS13155	COG0583	DNA-binding transcription factor activity
EPC_RS13165	COG0737	Belongs to the 5'-nucleotidase family
EPC_RS13170	COG2223	nitrite transmembrane transporter activity
EPC_RS13175	COG4651	solute:proton antiporter activity
EPC_RS13175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPC_RS13185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPC_RS13190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPC_RS13195	COG0563	adenylate kinase activity
EPC_RS13210	COG0494	nUDIX hydrolase
EPC_RS13220	COG0583	DNA-binding transcription factor activity
EPC_RS13230	COG0003	Pfam Anion-transporting ATPase
EPC_RS13240	COG0326	Molecular chaperone. Has ATPase activity
EPC_RS13245	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPC_RS13250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EPC_RS13255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EPC_RS13260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EPC_RS13265	COG2832	Protein of unknown function (DUF454)
EPC_RS13280	COG1309	transcriptional regulator
EPC_RS13285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPC_RS13290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPC_RS13295	COG0254	rRNA binding
EPC_RS13300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPC_RS13320	COG3695	enzyme binding
EPC_RS13325	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EPC_RS13330	COG1946	Acyl-CoA thioesterase
EPC_RS13335	COG0004	ammonium transporteR
EPC_RS13340	COG0347	Belongs to the P(II) protein family
EPC_RS13345	COG1132	(ABC) transporter
EPC_RS13350	COG1132	(ABC) transporter
EPC_RS13355	COG1522	sequence-specific DNA binding
EPC_RS13365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EPC_RS13370	COG0824	Thioesterase
EPC_RS13375	COG1555	photosystem II stabilization
EPC_RS13380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPC_RS13400	COG0740	serine-type endopeptidase activity
EPC_RS13410	COG0740	serine-type endopeptidase activity
EPC_RS13415	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPC_RS13420	COG0271	Belongs to the BolA IbaG family
EPC_RS13425	COG3056	Lipoprotein
EPC_RS13430	COG2223	nitrite transmembrane transporter activity
EPC_RS13435	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPC_RS13440	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EPC_RS13445	COG1845	cytochrome c oxidase, subunit III
EPC_RS13450	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EPC_RS13455	COG0109	protoheme IX farnesyltransferase activity
EPC_RS13460	COG2814	Major facilitator Superfamily
EPC_RS13465	COG2963	transposase activity
EPC_RS13470	COG2801	Transposase and inactivated derivatives
EPC_RS13475	COG5290	Psort location Cytoplasmic, score
EPC_RS13485	COG1666	GTP binding
EPC_RS13490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EPC_RS13500	COG0301	tRNA thio-modification
EPC_RS13500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPC_RS13505	COG1722	exodeoxyribonuclease VII activity
EPC_RS13510	COG0142	geranyltranstransferase activity
EPC_RS13515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EPC_RS13520	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EPC_RS13525	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPC_RS13530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPC_RS13535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EPC_RS13540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPC_RS13540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPC_RS13545	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EPC_RS13550	COG1652	LysM domain
EPC_RS13560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPC_RS13565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPC_RS13570	COG1862	Preprotein translocase
EPC_RS13575	COG0343	queuine tRNA-ribosyltransferase activity
EPC_RS13580	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPC_RS13585	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EPC_RS13590	COG0450	alkyl hydroperoxide reductase
EPC_RS13605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EPC_RS13615	COG5002	protein histidine kinase activity
EPC_RS13625	COG0420	3'-5' exonuclease activity
EPC_RS13630	COG0419	ATPase involved in DNA repair
EPC_RS13675	COG2974	May be involved in recombination
EPC_RS13680	COG3123	guanosine phosphorylase activity
EPC_RS13700	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPC_RS13705	COG3416	Protein conserved in bacteria
EPC_RS13710	COG1671	Belongs to the UPF0178 family
EPC_RS13715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EPC_RS13735	COG1278	Cold shock
EPC_RS13755	COG0747	negative chemotaxis
EPC_RS13760	COG0601	transmembrane transport
EPC_RS13765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPC_RS13770	COG0444	Belongs to the ABC transporter superfamily
EPC_RS13775	COG4608	Belongs to the ABC transporter superfamily
EPC_RS13780	COG4166	transmembrane transport
EPC_RS13830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EPC_RS13835	COG2832	Protein of unknown function (DUF454)
EPC_RS13855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EPC_RS13860	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EPC_RS13875	COG1073	alpha beta
EPC_RS13880	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EPC_RS13885	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPC_RS13895	COG3034	peptidoglycan biosynthetic process
EPC_RS13900	COG0121	glutamine amidotransferase
EPC_RS13905	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPC_RS13910	COG1960	acyl-CoA dehydrogenase activity
EPC_RS13915	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EPC_RS13925	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EPC_RS13930	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
EPC_RS13950	COG0436	Aminotransferase
EPC_RS13955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPC_RS13960	COG2233	PERMEase
EPC_RS13965	COG2351	hydroxyisourate hydrolase activity
EPC_RS13980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPC_RS13990	COG0765	amino acid transport
EPC_RS13995	COG0765	amino acid transport
EPC_RS14035	COG1715	Restriction endonuclease
EPC_RS14040	COG2189	Belongs to the N(4) N(6)-methyltransferase family
EPC_RS14070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPC_RS14075	COG0328	RNA-DNA hybrid ribonuclease activity
EPC_RS14080	COG2226	methyltransferase
EPC_RS14085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPC_RS14090	COG1388	LysM domain
EPC_RS14090	COG0741	lytic transglycosylase activity
EPC_RS14095	COG2226	methyltransferase
EPC_RS14100	COG3021	interspecies interaction between organisms
EPC_RS14130	COG0542	response to heat
EPC_RS14140	COG0564	pseudouridine synthase activity
EPC_RS14145	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPC_RS14150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPC_RS14155	COG0077	Prephenate dehydratase
EPC_RS14155	COG1605	Chorismate mutase
EPC_RS14160	COG1605	Chorismate mutase
EPC_RS14160	COG0287	Prephenate dehydrogenase
EPC_RS14165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPC_RS14175	COG0504	CTP synthase activity
EPC_RS14190	COG0335	large ribosomal subunit rRNA binding
EPC_RS14205	COG0228	four-way junction DNA binding
EPC_RS14210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPC_RS14215	COG4137	Cytochrome C assembly protein
EPC_RS14220	COG4536	flavin adenine dinucleotide binding
EPC_RS14230	COG2918	glutathione biosynthetic process
EPC_RS14235	COG1238	metal cluster binding
EPC_RS14240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPC_RS14265	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EPC_RS14280	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPC_RS14285	COG1546	Belongs to the CinA family
EPC_RS14290	COG2951	lytic endotransglycosylase activity
EPC_RS14295	COG5455	response to cobalt ion
EPC_RS14310	COG2801	Transposase and inactivated derivatives
EPC_RS14365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPC_RS14375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPC_RS14385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPC_RS14390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EPC_RS14395	COG0585	pseudouridine synthase activity
EPC_RS14400	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EPC_RS14410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EPC_RS14420	COG0529	Catalyzes the synthesis of activated sulfate
EPC_RS14425	COG2895	sulfate adenylyltransferase (ATP) activity
EPC_RS14430	COG0175	sulfate reduction
EPC_RS14435	COG1648	precorrin-2 dehydrogenase activity
EPC_RS14435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPC_RS14445	COG0175	sulfate reduction
EPC_RS14450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPC_RS14460	COG0720	synthase
EPC_RS14465	COG0765	amino acid transport
EPC_RS14470	COG1126	abc transporter atp-binding protein
EPC_RS14475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPC_RS14480	COG0602	queuosine metabolic process
EPC_RS14485	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPC_RS14485	COG2755	lipolytic protein G-D-S-L family
EPC_RS14490	COG0148	phosphopyruvate hydratase activity
EPC_RS14495	COG0504	CTP synthase activity
EPC_RS14500	COG3956	TIGRFAM MazG family protein
EPC_RS14505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPC_RS14510	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPC_RS14520	COG1929	Belongs to the glycerate kinase type-1 family
EPC_RS14525	COG0716	FMN binding
EPC_RS14530	COG0564	pseudouridine synthase activity
EPC_RS14535	COG3098	single-species biofilm formation
EPC_RS14545	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPC_RS14545	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPC_RS14550	COG1611	Belongs to the LOG family
EPC_RS14560	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EPC_RS14565	COG2363	Small membrane protein
EPC_RS14570	COG0583	DNA-binding transcription factor activity
EPC_RS14580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPC_RS14585	COG2166	iron-sulfur cluster assembly
EPC_RS14590	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EPC_RS14595	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EPC_RS14615	COG0860	N-Acetylmuramoyl-L-alanine amidase
EPC_RS14620	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPC_RS14620	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPC_RS14630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPC_RS14635	COG1074	ATP-dependent DNA helicase activity
EPC_RS14645	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EPC_RS14660	COG4795	General secretion pathway protein
EPC_RS14670	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EPC_RS14675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EPC_RS14680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EPC_RS14690	COG1051	belongs to the nudix hydrolase family
EPC_RS14700	COG0861	Integral membrane protein TerC family
EPC_RS14710	COG0667	Aldo Keto reductase
EPC_RS14720	COG0318	PFAM AMP-dependent synthetase and ligase
EPC_RS14720	COG0204	Acyl-transferase
EPC_RS14750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPC_RS14755	COG0768	penicillin binding
EPC_RS14760	COG2831	hemolysin activation secretion protein
EPC_RS14765	COG3210	domain, Protein
EPC_RS14790	COG0358	DNA primase activity
EPC_RS14795	COG4974	Belongs to the 'phage' integrase family
EPC_RS14830	COG4974	Belongs to the 'phage' integrase family
EPC_RS14850	COG2801	Transposase and inactivated derivatives
EPC_RS14870	COG3210	domain, Protein
EPC_RS14890	COG1609	Transcriptional regulator
EPC_RS14900	COG0583	DNA-binding transcription factor activity
EPC_RS14905	COG2814	Major facilitator Superfamily
EPC_RS14915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EPC_RS14920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EPC_RS14930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPC_RS14935	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPC_RS14940	COG4974	Belongs to the 'phage' integrase family
EPC_RS14945	COG0697	spore germination
EPC_RS14950	COG0716	FMN binding
EPC_RS14960	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EPC_RS14965	COG0354	folic acid binding
EPC_RS14970	COG1272	protein, Hemolysin III
EPC_RS14980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EPC_RS14980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EPC_RS14985	COG0509	glycine decarboxylation via glycine cleavage system
EPC_RS14990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EPC_RS15000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPC_RS15005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPC_RS15010	COG0006	proline dipeptidase activity
EPC_RS15015	COG3079	Belongs to the UPF0149 family
EPC_RS15020	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EPC_RS15025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EPC_RS15030	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPC_RS15035	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EPC_RS15040	COG0583	DNA-binding transcription factor activity
EPC_RS15055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPC_RS15065	COG0673	inositol 2-dehydrogenase activity
EPC_RS15090	COG0668	transmembrane transport
EPC_RS15095	COG0191	fructose-bisphosphate aldolase activity
EPC_RS15100	COG0126	phosphoglycerate kinase activity
EPC_RS15105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPC_RS15110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPC_RS15115	COG0501	Belongs to the peptidase M48B family
EPC_RS15135	COG1166	arginine decarboxylase activity
EPC_RS15140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EPC_RS15145	COG2814	Major facilitator Superfamily
EPC_RS15150	COG3091	SprT-like family
EPC_RS15155	COG2356	endonuclease I
EPC_RS15160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPC_RS15170	COG1678	Uncharacterized ACR, COG1678
EPC_RS15175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPC_RS15200	COG2805	Type II/IV secretion system protein
EPC_RS15205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EPC_RS15210	COG0762	integral membrane protein
EPC_RS15215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPC_RS15220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPC_RS15235	COG3171	Protein conserved in bacteria
EPC_RS15250	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EPC_RS15255	COG0741	lytic transglycosylase activity
EPC_RS15265	COG1982	Orn Lys Arg decarboxylase major
EPC_RS15275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EPC_RS15505	COG0667	Aldo Keto reductase
EPC_RS15510	COG0656	L-ascorbic acid biosynthetic process
EPC_RS15525	COG2814	Major facilitator Superfamily
EPC_RS15545	COG1028	Short-chain dehydrogenase reductase Sdr
EPC_RS15555	COG0583	DNA-binding transcription factor activity
EPC_RS15565	COG0583	DNA-binding transcription factor activity
EPC_RS15580	COG5297	Belongs to the glycosyl hydrolase family 6
EPC_RS15660	COG2197	response regulator
EPC_RS15690	COG1157	protein secretion by the type III secretion system
EPC_RS15715	COG4794	Type iii secretion
EPC_RS15725	COG4792	protein secretion
EPC_RS15740	COG0151	Belongs to the GarS family
EPC_RS15780	COG1966	Carbon starvation protein
EPC_RS15785	COG3275	phosphorelay sensor kinase activity
EPC_RS15800	COG0697	spore germination
EPC_RS15805	COG1522	sequence-specific DNA binding
EPC_RS15815	COG1609	Transcriptional regulator
EPC_RS15825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EPC_RS15830	COG1447	Phosphotransferase system cellobiose-specific component IIA
EPC_RS15835	COG2723	6-phospho-beta-galactosidase activity
EPC_RS15850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EPC_RS15860	COG1528	Iron-storage protein
EPC_RS15890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPC_RS15920	COG1028	Short-chain dehydrogenase reductase Sdr
EPC_RS15930	COG0848	biopolymer transport protein
EPC_RS15940	COG0626	cystathionine gamma-synthase activity
EPC_RS15945	COG0586	Pfam SNARE associated Golgi protein
EPC_RS15970	COG1396	sequence-specific DNA binding
EPC_RS15975	COG0358	DNA primase activity
EPC_RS15980	COG4974	Belongs to the 'phage' integrase family
EPC_RS16000	COG1396	sequence-specific DNA binding
EPC_RS16005	COG0358	DNA primase activity
EPC_RS16010	COG4974	Belongs to the 'phage' integrase family
EPC_RS16035	COG0358	DNA primase activity
EPC_RS16040	COG4974	Belongs to the 'phage' integrase family
EPC_RS16045	COG3077	Addiction module antitoxin, RelB DinJ family
EPC_RS16050	COG2026	Addiction module toxin, RelE StbE family
EPC_RS16075	COG0358	DNA primase activity
EPC_RS16080	COG4974	Belongs to the 'phage' integrase family
EPC_RS16105	COG0358	DNA primase activity
EPC_RS16110	COG4974	Belongs to the 'phage' integrase family
EPC_RS16115	COG3077	Addiction module antitoxin, RelB DinJ family
EPC_RS16120	COG2026	Addiction module toxin, RelE StbE family
EPC_RS16145	COG0358	DNA primase activity
EPC_RS16150	COG4974	Belongs to the 'phage' integrase family
EPC_RS16235	COG3328	transposase activity
EPC_RS16240	COG3328	transposase activity
EPC_RS16245	COG3328	transposase activity
EPC_RS16265	COG2801	Transposase and inactivated derivatives
EPC_RS16275	COG2963	transposase activity
EPC_RS16285	COG3328	transposase activity
EPC_RS16310	COG0741	lytic transglycosylase activity
EPC_RS16325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPC_RS16380	COG0076	glutamate decarboxylase activity
EPC_RS16385	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EPC_RS16395	COG4774	siderophore transport
EPC_RS16405	COG1028	Short-chain dehydrogenase reductase Sdr
EPC_RS16415	COG5383	Protein conserved in bacteria
EPC_RS16430	COG0583	DNA-binding transcription factor activity
EPC_RS16445	COG0583	DNA-binding transcription factor activity
EPC_RS16455	COG2801	Transposase and inactivated derivatives
EPC_RS16490	COG5001	Diguanylate cyclase
EPC_RS16490	COG3300	MHYT domain
EPC_RS16495	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EPC_RS16510	COG0840	transmembrane signaling receptor activity
EPC_RS16515	COG1301	dicarboxylic acid transport
EPC_RS16525	COG3162	membrane
EPC_RS16530	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPC_RS16545	COG0583	DNA-binding transcription factor activity
EPC_RS16550	COG0025	NhaP-type Na H and K H
EPC_RS16560	COG2252	PERMEase
EPC_RS16590	COG3210	domain, Protein
EPC_RS16595	COG2831	hemolysin activation secretion protein
EPC_RS16605	COG3609	addiction module antidote protein, CC2985 family
EPC_RS16615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPC_RS16620	COG1064	alcohol dehydrogenase
EPC_RS16630	COG1388	LysM domain
EPC_RS16630	COG1470	cell adhesion involved in biofilm formation
EPC_RS16635	COG2315	Protein conserved in bacteria
EPC_RS16650	COG1470	cell adhesion involved in biofilm formation
EPC_RS16650	COG1388	LysM domain
EPC_RS16655	COG2315	Protein conserved in bacteria
EPC_RS16660	COG1470	cell adhesion involved in biofilm formation
EPC_RS16660	COG1388	LysM domain
EPC_RS16665	COG2315	Protein conserved in bacteria
EPC_RS16680	COG1470	cell adhesion involved in biofilm formation
EPC_RS16680	COG1388	LysM domain
EPC_RS16690	COG1448	Aminotransferase
EPC_RS16695	COG1522	sequence-specific DNA binding
EPC_RS16715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPC_RS16725	COG0735	belongs to the Fur family
EPC_RS16730	COG3237	CsbD-like
EPC_RS16735	COG0534	Mate efflux family protein
EPC_RS16740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPC_RS16745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPC_RS16760	COG3161	chorismate lyase activity
EPC_RS16765	COG3223	Belongs to the PsiE family
EPC_RS16770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPC_RS16790	COG0166	Belongs to the GPI family
EPC_RS16795	COG0527	aspartate kinase activity
EPC_RS16800	COG1283	sodium-dependent phosphate transmembrane transporter activity
EPC_RS16805	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EPC_RS16835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPC_RS16845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EPC_RS16855	COG0551	DNA topoisomerase type I activity
EPC_RS16865	COG0758	DNA mediated transformation
EPC_RS16870	COG0242	peptide deformylase activity
EPC_RS16875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPC_RS16880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPC_RS16880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPC_RS16890	COG1970	mechanosensitive ion channel activity
EPC_RS16895	COG3036	rescue of stalled ribosome
EPC_RS16900	COG0789	Transcriptional regulator
EPC_RS16910	COG0203	ribosomal protein L17
EPC_RS16915	COG0202	RNA polymerase activity
EPC_RS16920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EPC_RS16925	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPC_RS16930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPC_RS16935	COG0201	protein transport
EPC_RS16940	COG0200	Binds to the 23S rRNA
EPC_RS16945	COG1841	ribosomal large subunit assembly
EPC_RS16955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EPC_RS16960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EPC_RS16965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EPC_RS16970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EPC_RS16975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EPC_RS16980	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EPC_RS16985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EPC_RS16990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EPC_RS16995	COG0255	Belongs to the universal ribosomal protein uL29 family
EPC_RS17000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EPC_RS17010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EPC_RS17015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EPC_RS17020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EPC_RS17025	COG0089	rRNA binding
EPC_RS17030	COG0088	Forms part of the polypeptide exit tunnel
EPC_RS17035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPC_RS17040	COG0051	transcription antitermination factor activity, RNA binding
EPC_RS17050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPC_RS17055	COG0049	tRNA binding
EPC_RS17060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EPC_RS17065	COG2168	tRNA wobble position uridine thiolation
EPC_RS17070	COG2923	Belongs to the DsrF TusC family
EPC_RS17075	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EPC_RS17080	COG2964	Protein conserved in bacteria
EPC_RS17085	COG0545	Peptidyl-prolyl cis-trans isomerase
EPC_RS17090	COG2900	Belongs to the SlyX family
EPC_RS17095	COG1047	Peptidyl-prolyl cis-trans
EPC_RS17100	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EPC_RS17105	COG0475	glutathione-regulated potassium exporter activity
EPC_RS17105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPC_RS17110	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPC_RS17115	COG0488	(ABC) transporter
EPC_RS17120	COG2175	clavaminate synthase activity
EPC_RS17125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPC_RS17135	COG4521	taurine ABC transporter
EPC_RS17145	COG0429	hydrolase of the alpha beta-hydrolase fold
EPC_RS17150	COG3089	Belongs to the UPF0270 family
EPC_RS17155	COG3954	Phosphoribulokinase
EPC_RS17160	COG1765	OsmC-like protein
EPC_RS17170	COG1289	transmembrane transporter activity
EPC_RS17175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPC_RS17195	COG0738	Major facilitator superfamily
EPC_RS17205	COG0402	S-adenosylhomocysteine deaminase activity
EPC_RS17225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPC_RS17235	COG3266	domain, Protein
EPC_RS17235	COG3266	domain, Protein
EPC_RS17240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EPC_RS17245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPC_RS17250	COG4796	Type ii and iii secretion system protein
EPC_RS17275	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EPC_RS17280	COG0494	nUDIX hydrolase
EPC_RS17290	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EPC_RS17295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EPC_RS17300	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EPC_RS17315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPC_RS17320	COG2183	response to ionizing radiation
EPC_RS17335	COG2267	carboxylic ester hydrolase activity
EPC_RS17340	COG1040	competence protein
EPC_RS17345	COG0316	Belongs to the HesB IscA family
EPC_RS17345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EPC_RS17350	COG1640	4-alpha-glucanotransferase
EPC_RS17355	COG0058	SHG alpha-glucan phosphorylase activity
EPC_RS17360	COG1349	DNA-binding transcription factor activity
EPC_RS17365	COG0705	Rhomboid family
EPC_RS17370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPC_RS17375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPC_RS17400	COG0058	SHG alpha-glucan phosphorylase activity
EPC_RS17415	COG0058	SHG alpha-glucan phosphorylase activity
EPC_RS17445	COG0058	SHG alpha-glucan phosphorylase activity
EPC_RS17450	COG0297	glycogen (starch) synthase activity
EPC_RS17460	COG1523	belongs to the glycosyl hydrolase 13 family
EPC_RS17475	COG2610	gluconate transmembrane transporter activity
EPC_RS17480	COG3265	gluconokinase activity
EPC_RS17485	COG1609	Transcriptional regulator
EPC_RS17490	COG1741	Belongs to the pirin family
EPC_RS17500	COG1247	-acetyltransferase
EPC_RS17505	COG0405	Gamma-glutamyltransferase
EPC_RS17510	COG3077	Addiction module antitoxin, RelB DinJ family
EPC_RS17530	COG0405	Gamma-glutamyltransferase
EPC_RS17535	COG0405	Gamma-glutamyltransferase
EPC_RS17545	COG0584	glycerophosphoryl diester phosphodiesterase
EPC_RS17555	COG1653	transport
EPC_RS17570	COG0411	ABC transporter
EPC_RS17575	COG4177	L-phenylalanine transmembrane transporter activity
EPC_RS17600	COG2177	Part of the ABC transporter FtsEX involved in
EPC_RS17605	COG2884	Cell division ATP-binding protein ftsE
EPC_RS17610	COG0552	protein localization to endoplasmic reticulum
EPC_RS17615	COG0742	ribosomal rna small subunit methyltransferase
EPC_RS17620	COG3776	membrane
EPC_RS17630	COG3714	YhhN family
EPC_RS17640	COG0425	Belongs to the sulfur carrier protein TusA family
EPC_RS17645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EPC_RS17655	COG1082	Xylose isomerase domain protein TIM barrel
EPC_RS17660	COG1082	Xylose isomerase domain protein TIM barrel
EPC_RS17665	COG0673	inositol 2-dehydrogenase activity
EPC_RS17670	COG3962	Belongs to the TPP enzyme family
EPC_RS17675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPC_RS17685	COG3718	enzyme involved in inositol metabolism
EPC_RS17695	COG0628	permease
EPC_RS17705	COG2200	EAL domain
EPC_RS17715	COG1064	alcohol dehydrogenase
EPC_RS17725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPC_RS17750	COG2081	HI0933 family
EPC_RS17755	COG0306	phosphate transporter
EPC_RS17765	COG0589	response to stress
EPC_RS17770	COG0742	ribosomal rna small subunit methyltransferase
EPC_RS17795	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EPC_RS17800	COG1234	tRNA 3'-trailer cleavage
EPC_RS17825	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EPC_RS17830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPC_RS17845	COG3038	cytochrome b561
EPC_RS17870	COG4974	Belongs to the 'phage' integrase family
EPC_RS17885	COG3210	domain, Protein
EPC_RS17915	COG2862	Uncharacterized protein family, UPF0114
EPC_RS17955	COG1132	(ABC) transporter
EPC_RS17975	COG3386	PFAM SMP-30 Gluconolaconase
EPC_RS17985	COG2801	Transposase and inactivated derivatives
EPC_RS18000	COG2205	protein histidine kinase activity
EPC_RS18005	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EPC_RS18010	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EPC_RS18015	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EPC_RS18050	COG3328	transposase activity
EPC_RS18085	COG1971	Probably functions as a manganese efflux pump
EPC_RS18110	COG0477	Major facilitator Superfamily
EPC_RS18115	COG2982	Protein involved in outer membrane biogenesis
EPC_RS18120	COG2200	EAL domain
EPC_RS18125	COG0612	Peptidase, M16
EPC_RS18130	COG1301	dicarboxylic acid transport
EPC_RS18135	COG2199	diguanylate cyclase activity
EPC_RS18135	COG2200	EAL domain
EPC_RS18145	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EPC_RS18155	COG0457	Tetratricopeptide repeat
EPC_RS18160	COG1215	transferase activity, transferring glycosyl groups
EPC_RS18165	COG1215	transferase activity, transferring glycosyl groups
EPC_RS18170	COG2894	cell division
EPC_RS18180	COG4608	Belongs to the ABC transporter superfamily
EPC_RS18185	COG0444	Belongs to the ABC transporter superfamily
EPC_RS18190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPC_RS18195	COG0601	transmembrane transport
EPC_RS18200	COG0747	negative chemotaxis
EPC_RS18210	COG1764	response to oxidative stress
EPC_RS18215	COG1846	Transcriptional regulator
EPC_RS18240	COG3328	transposase activity
EPC_RS18270	COG0246	Mannitol dehydrogenase
EPC_RS18280	COG3274	enterobacterial common antigen metabolic process
EPC_RS18285	COG0752	glycyl-tRNA synthetase alpha subunit
EPC_RS18290	COG0751	glycine-tRNA ligase activity
EPC_RS18295	COG1064	alcohol dehydrogenase
EPC_RS18300	COG2944	sequence-specific DNA binding
EPC_RS18310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPC_RS18310	COG2213	PTS system mannitol-specific
EPC_RS18315	COG0246	Mannitol dehydrogenase
EPC_RS18320	COG3722	fumarate hydratase activity
EPC_RS18340	COG0745	RESPONSE REGULATOR receiver
EPC_RS18350	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPC_RS18355	COG1129	ABC transporter
EPC_RS18360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EPC_RS18365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPC_RS18370	COG1349	DNA-binding transcription factor activity
EPC_RS18385	COG3058	Necessary for formate dehydrogenase activity
EPC_RS18390	COG0625	glutathione transferase activity
EPC_RS18395	COG2818	Glycosylase
EPC_RS18400	COG1609	Transcriptional regulator
EPC_RS18415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPC_RS18420	COG2271	Major facilitator Superfamily
EPC_RS18425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPC_RS18440	COG3977	Valine--pyruvate aminotransferase
EPC_RS18455	COG5645	(Lipo)protein
EPC_RS18460	COG0823	Involved in the tonB-independent uptake of proteins
EPC_RS18465	COG0561	phosphatase activity
EPC_RS18475	COG0187	DNA topoisomerase II activity
EPC_RS18480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPC_RS18485	COG0592	DNA-directed DNA polymerase activity
EPC_RS18490	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPC_RS18500	COG0706	membrane insertase activity
EPC_RS18505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EPC_RS18515	COG2252	PERMEase
EPC_RS18525	COG0704	Plays a role in the regulation of phosphate uptake
EPC_RS18530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPC_RS18535	COG0581	inorganic phosphate transmembrane transporter activity
EPC_RS18540	COG0573	inorganic phosphate transmembrane transporter activity
EPC_RS18545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPC_RS18560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPC_RS18565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EPC_RS18570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPC_RS18575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPC_RS18580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPC_RS18585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPC_RS18590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPC_RS18595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EPC_RS18605	COG0356	it plays a direct role in the translocation of protons across the membrane
EPC_RS18610	COG3312	ion transport
EPC_RS18615	COG0357	Ribosomal RNA small subunit methyltransferase G
EPC_RS18650	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EPC_RS18665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPC_RS18680	COG1280	lysine exporter protein (LysE YggA)
EPC_RS18705	COG0058	SHG alpha-glucan phosphorylase activity