locus-tag	class	description
I6I62_RS00015	COG1131	(ABC) transporter
I6I62_RS00035	COG0813	purine-nucleoside phosphorylase activity
I6I62_RS00045	COG2155	Conserved Protein
I6I62_RS00050	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6I62_RS00055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I62_RS00070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I62_RS00120	COG1131	(ABC) transporter
I6I62_RS00130	COG0745	RESPONSE REGULATOR receiver
I6I62_RS00145	COG1876	peptidase activity
I6I62_RS00175	COG1136	(ABC) transporter
I6I62_RS00175	COG0577	efflux transmembrane transporter activity
I6I62_RS00190	COG4989	oxidoreductase activity
I6I62_RS00200	COG2385	sporulation resulting in formation of a cellular spore
I6I62_RS00235	COG1737	Transcriptional regulator
I6I62_RS00255	COG0561	phosphatase activity
I6I62_RS00265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I62_RS00280	COG0557	exoribonuclease II activity
I6I62_RS00285	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I62_RS00310	COG0456	acetyltransferase
I6I62_RS00320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS00325	COG0561	phosphatase activity
I6I62_RS00340	COG0583	DNA-binding transcription factor activity
I6I62_RS00355	COG0656	L-ascorbic acid biosynthetic process
I6I62_RS00365	COG0656	L-ascorbic acid biosynthetic process
I6I62_RS00370	COG0488	(ABC) transporter
I6I62_RS00385	COG0583	DNA-binding transcription factor activity
I6I62_RS00395	COG2207	Transcriptional regulator
I6I62_RS00395	COG3708	Transcriptional regulator
I6I62_RS00400	COG0733	neurotransmitter:sodium symporter activity
I6I62_RS00405	COG0714	Associated with various cellular activities
I6I62_RS00430	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6I62_RS00435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I62_RS00440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6I62_RS00455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I62_RS00460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I62_RS00470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I62_RS00475	COG4641	Protein conserved in bacteria
I6I62_RS00475	COG0438	transferase activity, transferring glycosyl groups
I6I62_RS00485	COG0438	transferase activity, transferring glycosyl groups
I6I62_RS00495	COG1216	Glycosyl transferase, family 2
I6I62_RS00525	COG3328	transposase activity
I6I62_RS00545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I62_RS00550	COG1606	tRNA processing
I6I62_RS00560	COG0310	cobalt ion transport
I6I62_RS00570	COG1122	ATPase activity
I6I62_RS00575	COG1691	(AIR) carboxylase
I6I62_RS00580	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I6I62_RS00585	COG0534	Mate efflux family protein
I6I62_RS00605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I62_RS00610	COG0561	phosphatase activity
I6I62_RS00620	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I62_RS00630	COG1349	DNA-binding transcription factor activity
I6I62_RS00635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I62_RS00640	COG1882	Formate acetyltransferase
I6I62_RS00650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I62_RS00660	COG0561	phosphatase activity
I6I62_RS00715	COG0488	(ABC) transporter
I6I62_RS00720	COG3706	GGDEF domain
I6I62_RS00730	COG1486	melibiose metabolic process
I6I62_RS00735	COG1737	Transcriptional regulator
I6I62_RS00740	COG1609	Transcriptional regulator
I6I62_RS00745	COG1263	PTS System
I6I62_RS00745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS00745	COG2190	(PTS) system
I6I62_RS00750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I62_RS00760	COG1263	PTS System
I6I62_RS00760	COG2190	(PTS) system
I6I62_RS00760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS00765	COG0698	ribose 5-phosphate isomerase
I6I62_RS00775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS00775	COG1263	PTS System
I6I62_RS00790	COG1263	PTS System
I6I62_RS00790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS00790	COG2190	(PTS) system
I6I62_RS00795	COG0534	Mate efflux family protein
I6I62_RS00805	COG0459	protein refolding
I6I62_RS00820	COG2116	formate transmembrane transporter activity
I6I62_RS00835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I62_RS00850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I62_RS00855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I62_RS00875	COG1592	Rubrerythrin
I6I62_RS00885	COG0561	phosphatase activity
I6I62_RS00895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I62_RS00965	COG0165	Argininosuccinate lyase
I6I62_RS00970	COG0137	argininosuccinate synthase activity
I6I62_RS00975	COG0628	permease
I6I62_RS00980	COG1131	(ABC) transporter
I6I62_RS00990	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I62_RS00995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I62_RS01000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I62_RS01005	COG1408	metallophosphoesterase
I6I62_RS01010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I62_RS01020	COG2188	Transcriptional regulator
I6I62_RS01025	COG1131	(ABC) transporter
I6I62_RS01040	COG3118	belongs to the thioredoxin family
I6I62_RS01050	COG4808	Protein conserved in bacteria
I6I62_RS01065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I62_RS01080	COG1363	Peptidase, m42
I6I62_RS01085	COG0561	phosphatase activity
I6I62_RS01090	COG2188	Transcriptional regulator
I6I62_RS01095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I62_RS01100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS01100	COG1263	PTS System
I6I62_RS01105	COG0366	Alpha amylase catalytic
I6I62_RS01110	COG4868	Belongs to the UPF0371 family
I6I62_RS01125	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6I62_RS01130	COG1459	type II secretion system
I6I62_RS01165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I62_RS01180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I62_RS01190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I62_RS01195	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS01200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I62_RS01205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I62_RS01220	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS01235	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I62_RS01245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I62_RS01285	COG0527	aspartate kinase activity
I6I62_RS01290	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS01300	COG1609	Transcriptional regulator
I6I62_RS01305	COG1263	PTS System
I6I62_RS01305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS01310	COG1621	beta-fructofuranosidase activity
I6I62_RS01320	COG4585	Histidine kinase
I6I62_RS01325	COG2197	response regulator
I6I62_RS01350	COG3716	PTS system mannose fructose sorbose family IID component
I6I62_RS01360	COG1132	(ABC) transporter
I6I62_RS01365	COG1132	(ABC) transporter
I6I62_RS01380	COG0745	RESPONSE REGULATOR receiver
I6I62_RS01385	COG5002	protein histidine kinase activity
I6I62_RS01390	COG1136	(ABC) transporter
I6I62_RS01410	COG1217	gtp-binding protein TYPA
I6I62_RS01440	COG1122	ATPase activity
I6I62_RS01460	COG2207	Transcriptional regulator
I6I62_RS01460	COG1917	Cupin 2, conserved barrel domain protein
I6I62_RS01470	COG1175	transmembrane transport
I6I62_RS01475	COG0395	ABC-type sugar transport system, permease component
I6I62_RS01485	COG3842	ATPase activity
I6I62_RS01490	COG5426	von Willebrand factor, type A
I6I62_RS01510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I62_RS01520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I62_RS01525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS01535	COG1609	Transcriptional regulator
I6I62_RS01545	COG0058	SHG alpha-glucan phosphorylase activity
I6I62_RS01550	COG1523	belongs to the glycosyl hydrolase 13 family
I6I62_RS01560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I62_RS01565	COG1309	transcriptional regulator
I6I62_RS01585	COG1739	Uncharacterized protein family UPF0029
I6I62_RS01590	COG1307	EDD domain protein, DegV family
I6I62_RS01595	COG1854	S-ribosylhomocysteine lyase activity
I6I62_RS01610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS01615	COG2081	HI0933 family
I6I62_RS01635	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6I62_RS01640	COG1278	Cold shock
I6I62_RS01645	COG0653	protein targeting
I6I62_RS01650	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I62_RS01655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I62_RS01665	COG2884	Cell division ATP-binding protein ftsE
I6I62_RS01670	COG2177	Part of the ABC transporter FtsEX involved in
I6I62_RS01685	COG1073	alpha beta
I6I62_RS01690	COG0488	(ABC) transporter
I6I62_RS01695	COG4978	Transcriptional regulator
I6I62_RS01695	COG0789	Transcriptional regulator
I6I62_RS01730	COG3546	catalase activity
I6I62_RS01745	COG1192	Involved in chromosome partitioning
I6I62_RS01760	COG3344	reverse transcriptase
I6I62_RS01890	COG0741	lytic transglycosylase activity
I6I62_RS01895	COG3757	hydrolase, family 25
I6I62_RS01925	COG1196	nuclear chromosome segregation
I6I62_RS01930	COG3409	Peptidoglycan-binding domain 1 protein
I6I62_RS01945	COG3409	Peptidoglycan-binding domain 1 protein
I6I62_RS01995	COG1131	(ABC) transporter
I6I62_RS02025	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6I62_RS02040	COG0488	(ABC) transporter
I6I62_RS02045	COG0778	Nitroreductase
I6I62_RS02055	COG1132	(ABC) transporter
I6I62_RS02060	COG1132	(ABC) transporter
I6I62_RS02075	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I62_RS02080	COG2171	N-acyltransferase activity
I6I62_RS02085	COG1473	amidohydrolase
I6I62_RS02090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I62_RS02095	COG2059	Chromate
I6I62_RS02110	COG1459	type II secretion system
I6I62_RS02145	COG4932	domain protein
I6I62_RS02145	COG3266	domain, Protein
I6I62_RS02145	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I62_RS02160	COG1132	(ABC) transporter
I6I62_RS02165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I62_RS02170	COG0295	cytidine deaminase activity
I6I62_RS02175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I62_RS02195	COG0423	glycine-tRNA ligase activity
I6I62_RS02200	COG0358	DNA primase activity
I6I62_RS02205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I62_RS02210	COG2384	SAM-dependent methyltransferase
I6I62_RS02220	COG0561	phosphatase activity
I6I62_RS02225	COG0534	Mate efflux family protein
I6I62_RS02230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I62_RS02240	COG0513	Belongs to the DEAD box helicase family
I6I62_RS02255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I62_RS02265	COG1164	Oligoendopeptidase f
I6I62_RS02270	COG0268	Binds directly to 16S ribosomal RNA
I6I62_RS02305	COG0561	phosphatase activity
I6I62_RS02355	COG0250	Participates in transcription elongation, termination and antitermination
I6I62_RS02360	COG0489	protein tyrosine kinase activity
I6I62_RS02375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I62_RS02380	COG0438	transferase activity, transferring glycosyl groups
I6I62_RS02385	COG0438	transferase activity, transferring glycosyl groups
I6I62_RS02395	COG0463	Glycosyl transferase, family 2
I6I62_RS02425	COG0438	transferase activity, transferring glycosyl groups
I6I62_RS02445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I62_RS02460	COG1686	Belongs to the peptidase S11 family
I6I62_RS02495	COG0726	polysaccharide deacetylase
I6I62_RS02500	COG0628	permease
I6I62_RS02515	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6I62_RS02525	COG1357	PFAM Pentapeptide repeats (8 copies)
I6I62_RS02545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I62_RS02555	COG0583	DNA-binding transcription factor activity
I6I62_RS02560	COG1917	Cupin 2, conserved barrel domain protein
I6I62_RS02560	COG2207	Transcriptional regulator
I6I62_RS02565	COG0697	spore germination
I6I62_RS02575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I62_RS02590	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I62_RS02590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I62_RS02595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I62_RS02600	COG0134	indole-3-glycerol-phosphate synthase activity
I6I62_RS02610	COG0133	tryptophan synthase activity
I6I62_RS02615	COG0159	tryptophan synthase activity
I6I62_RS02620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I62_RS02630	COG2205	protein histidine kinase activity
I6I62_RS02635	COG0745	RESPONSE REGULATOR receiver
I6I62_RS02665	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS02670	COG0534	Mate efflux family protein
I6I62_RS02675	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS02695	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I62_RS02720	COG0772	Belongs to the SEDS family
I6I62_RS02730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I62_RS02735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I62_RS02740	COG0849	cell division
I6I62_RS02745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I62_RS02750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I62_RS02760	COG1191	sigma factor activity
I6I62_RS02765	COG1191	sigma factor activity
I6I62_RS02775	COG1799	cell septum assembly
I6I62_RS02790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I62_RS02795	COG0697	spore germination
I6I62_RS02800	COG1686	Belongs to the peptidase S11 family
I6I62_RS02805	COG1511	domain protein
I6I62_RS02810	COG1959	2 iron, 2 sulfur cluster binding
I6I62_RS02820	COG0546	phosphoglycolate phosphatase activity
I6I62_RS02830	COG1482	cell wall glycoprotein biosynthetic process
I6I62_RS02840	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6I62_RS02845	COG0346	lactoylglutathione lyase activity
I6I62_RS02850	COG0824	Thioesterase
I6I62_RS02860	COG0217	transcriptional regulatory protein
I6I62_RS02865	COG2081	HI0933 family
I6I62_RS02870	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
I6I62_RS02875	COG1971	Probably functions as a manganese efflux pump
I6I62_RS02880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I62_RS02885	COG0569	domain protein
I6I62_RS02890	COG0569	domain protein
I6I62_RS02900	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I62_RS02905	COG3870	Protein conserved in bacteria
I6I62_RS02910	COG0285	dihydrofolate synthase activity
I6I62_RS02915	COG3263	regulation of cellular component size
I6I62_RS02930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I62_RS02940	COG0697	spore germination
I6I62_RS02950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I62_RS02960	COG3706	GGDEF domain
I6I62_RS02965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I62_RS03010	COG2172	sigma factor antagonist activity
I6I62_RS03045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I62_RS03050	COG0494	nUDIX hydrolase
I6I62_RS03085	COG1597	lipid kinase activity
I6I62_RS03090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I62_RS03100	COG0667	Aldo Keto reductase
I6I62_RS03120	COG1410	methionine synthase
I6I62_RS03120	COG0646	methionine synthase
I6I62_RS03130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I62_RS03140	COG1272	protein, Hemolysin III
I6I62_RS03150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I62_RS03155	COG0564	pseudouridine synthase activity
I6I62_RS03175	COG1193	negative regulation of DNA recombination
I6I62_RS03180	COG0322	excinuclease ABC activity
I6I62_RS03185	COG2197	response regulator
I6I62_RS03190	COG1876	peptidase activity
I6I62_RS03195	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I62_RS03220	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6I62_RS03220	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I62_RS03230	COG3231	kanamycin kinase activity
I6I62_RS03235	COG2855	membrane
I6I62_RS03240	COG0583	DNA-binding transcription factor activity
I6I62_RS03250	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I62_RS03255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6I62_RS03260	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I62_RS03300	COG2003	Belongs to the UPF0758 family
I6I62_RS03305	COG1792	Involved in formation and maintenance of cell shape
I6I62_RS03315	COG0850	regulation of cytokinetic process
I6I62_RS03320	COG2894	cell division
I6I62_RS03330	COG1994	Peptidase M50
I6I62_RS03345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I62_RS03350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I62_RS03355	COG0632	four-way junction helicase activity
I6I62_RS03360	COG2255	four-way junction helicase activity
I6I62_RS03365	COG1555	photosystem II stabilization
I6I62_RS03365	COG1596	polysaccharide export
I6I62_RS03370	COG0658	competence protein
I6I62_RS03370	COG2333	competence protein COMEC
I6I62_RS03375	COG1466	dna polymerase III delta subunit
I6I62_RS03380	COG1760	l-serine dehydratase
I6I62_RS03385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I62_RS03390	COG1773	rubredoxin
I6I62_RS03390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I62_RS03395	COG1420	regulation of RNA biosynthetic process
I6I62_RS03400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I62_RS03420	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS03425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I62_RS03430	COG1302	Protein conserved in bacteria
I6I62_RS03435	COG1461	Dihydroxyacetone kinase
I6I62_RS03445	COG0582	viral genome integration into host DNA
I6I62_RS03450	COG0534	Mate efflux family protein
I6I62_RS03455	COG0583	DNA-binding transcription factor activity
I6I62_RS03470	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6I62_RS03470	COG3408	Glycogen debranching enzyme
I6I62_RS03485	COG1263	PTS System
I6I62_RS03485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS03485	COG2190	(PTS) system
I6I62_RS03490	COG3711	transcriptional antiterminator
I6I62_RS03495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS03505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I62_RS03510	COG0416	fatty acid biosynthetic process
I6I62_RS03515	COG0571	ribonuclease III activity
I6I62_RS03525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I62_RS03540	COG1396	sequence-specific DNA binding
I6I62_RS03545	COG3842	ATPase activity
I6I62_RS03550	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I62_RS03555	COG1177	transmembrane transport
I6I62_RS03670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I62_RS03675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I62_RS03715	COG0745	RESPONSE REGULATOR receiver
I6I62_RS03720	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I62_RS03725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I62_RS03730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I62_RS03740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I62_RS03750	COG0107	imidazoleglycerol-phosphate synthase activity
I6I62_RS03755	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6I62_RS03755	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I62_RS03760	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I62_RS03770	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I62_RS03775	COG1668	transmembrane transport
I6I62_RS03780	COG4555	ABC transporter
I6I62_RS03790	COG1476	TRANSCRIPTIONal
I6I62_RS03815	COG2011	ABC-type metal ion transport system permease component
I6I62_RS03820	COG1464	Belongs to the NlpA lipoprotein family
I6I62_RS03825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I62_RS03845	COG2378	regulation of single-species biofilm formation
I6I62_RS03850	COG0456	acetyltransferase
I6I62_RS03860	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I62_RS03865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I62_RS03890	COG1737	Transcriptional regulator
I6I62_RS03900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I62_RS03910	COG1160	GTP binding
I6I62_RS03925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6I62_RS03930	COG0531	amino acid
I6I62_RS03935	COG1362	aminopeptidase activity
I6I62_RS03955	COG3773	Cell wall hydrolase
I6I62_RS03970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS03975	COG0583	DNA-binding transcription factor activity
I6I62_RS03985	COG0789	Transcriptional regulator
I6I62_RS04000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I62_RS04010	COG0583	DNA-binding transcription factor activity
I6I62_RS04020	COG4978	Transcriptional regulator
I6I62_RS04020	COG0789	Transcriptional regulator
I6I62_RS04040	COG0667	Aldo Keto reductase
I6I62_RS04045	COG0588	phosphoglycerate mutase activity
I6I62_RS04050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I62_RS04065	COG0535	radical SAM domain protein
I6I62_RS04090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS04090	COG3711	transcriptional antiterminator
I6I62_RS04100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS04105	COG0363	glucosamine-6-phosphate deaminase activity
I6I62_RS04110	COG1486	melibiose metabolic process
I6I62_RS04115	COG1131	(ABC) transporter
I6I62_RS04135	COG1136	(ABC) transporter
I6I62_RS04135	COG0577	efflux transmembrane transporter activity
I6I62_RS04140	COG0583	DNA-binding transcription factor activity
I6I62_RS04155	COG1028	Short-chain dehydrogenase reductase Sdr
I6I62_RS04160	COG0667	Aldo Keto reductase
I6I62_RS04185	COG0561	phosphatase activity
I6I62_RS04205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I62_RS04225	COG2801	Transposase and inactivated derivatives
I6I62_RS04240	COG1737	Transcriptional regulator
I6I62_RS04245	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS04255	COG2315	Protein conserved in bacteria
I6I62_RS04280	COG2801	Transposase and inactivated derivatives
I6I62_RS04300	COG1733	regulation of RNA biosynthetic process
I6I62_RS04315	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS04320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I62_RS04345	COG0148	phosphopyruvate hydratase activity
I6I62_RS04350	COG1780	Probably involved in ribonucleotide reductase function
I6I62_RS04360	COG0789	Transcriptional regulator
I6I62_RS04395	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6I62_RS04400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I62_RS04405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I62_RS04410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I62_RS04415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I62_RS04420	COG0138	bifunctional purine biosynthesis protein purh
I6I62_RS04425	COG0151	Belongs to the GarS family
I6I62_RS04430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I62_RS04440	COG0561	phosphatase activity
I6I62_RS04460	COG3681	Belongs to the UPF0597 family
I6I62_RS04465	COG0583	DNA-binding transcription factor activity
I6I62_RS04475	COG0656	L-ascorbic acid biosynthetic process
I6I62_RS04490	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6I62_RS04500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6I62_RS04505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6I62_RS04525	COG1846	Transcriptional regulator
I6I62_RS04535	COG1132	(ABC) transporter
I6I62_RS04540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I62_RS04560	COG1546	Belongs to the CinA family
I6I62_RS04560	COG1058	Belongs to the CinA family
I6I62_RS04565	COG1461	Dihydroxyacetone kinase
I6I62_RS04570	COG0583	DNA-binding transcription factor activity
I6I62_RS04575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I62_RS04580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I62_RS04580	COG0519	Catalyzes the synthesis of GMP from XMP
I6I62_RS04595	COG0464	growth
I6I62_RS04615	COG0582	viral genome integration into host DNA
I6I62_RS04745	COG0464	growth
I6I62_RS04760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I62_RS04765	COG1028	Short-chain dehydrogenase reductase Sdr
I6I62_RS04770	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6I62_RS04780	COG0275	rRNA processing
I6I62_RS04790	COG1309	transcriptional regulator
I6I62_RS04795	COG1748	Saccharopine dehydrogenase
I6I62_RS04800	COG0488	(ABC) transporter
I6I62_RS04805	COG0488	(ABC) transporter
I6I62_RS04810	COG1129	ABC transporter
I6I62_RS04815	COG0534	Mate efflux family protein
I6I62_RS04850	COG1846	Transcriptional regulator
I6I62_RS04855	COG1132	(ABC) transporter
I6I62_RS04860	COG1132	(ABC) transporter
I6I62_RS04875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I62_RS04880	COG0726	polysaccharide deacetylase
I6I62_RS04895	COG1956	GAF domain-containing protein
I6I62_RS04930	COG1674	ftsk spoiiie
I6I62_RS04940	COG2946	Replication initiation factor
I6I62_RS04965	COG0596	Alpha beta hydrolase
I6I62_RS05005	COG0741	lytic transglycosylase activity
I6I62_RS05005	COG0791	NLP P60 protein
I6I62_RS05015	COG1309	transcriptional regulator
I6I62_RS05035	COG5002	protein histidine kinase activity
I6I62_RS05060	COG1136	(ABC) transporter
I6I62_RS05090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I62_RS05095	COG0372	Belongs to the citrate synthase family
I6I62_RS05100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I62_RS05120	COG2217	Heavy metal translocating P-type atpase
I6I62_RS05130	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I62_RS05130	COG1918	ferrous iron import across plasma membrane
I6I62_RS05135	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I62_RS05135	COG1918	ferrous iron import across plasma membrane
I6I62_RS05165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I62_RS05170	COG0693	protein deglycase activity
I6I62_RS05175	COG1773	rubredoxin
I6I62_RS05175	COG1592	Rubrerythrin
I6I62_RS05190	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I6I62_RS05200	COG0527	aspartate kinase activity
I6I62_RS05205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I62_RS05215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I62_RS05220	COG1674	ftsk spoiiie
I6I62_RS05225	COG1744	ABC transporter substrate-binding protein PnrA-like
I6I62_RS05230	COG3845	ABC transporter
I6I62_RS05235	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6I62_RS05240	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6I62_RS05250	COG0612	Peptidase, M16
I6I62_RS05260	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I62_RS05270	COG3763	UPF0154 protein
I6I62_RS05275	COG0406	alpha-ribazole phosphatase activity
I6I62_RS05280	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I62_RS05285	COG0187	DNA topoisomerase II activity
I6I62_RS05290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I62_RS05300	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6I62_RS05305	COG1534	Rna-binding protein
I6I62_RS05310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I62_RS05310	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6I62_RS05315	COG0799	negative regulation of ribosome biogenesis
I6I62_RS05320	COG2226	methyltransferase
I6I62_RS05325	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I62_RS05330	COG0826	peptidase U32
I6I62_RS05360	COG2848	UPF0210 protein
I6I62_RS05375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I62_RS05380	COG1396	sequence-specific DNA binding
I6I62_RS05425	COG1396	sequence-specific DNA binding
I6I62_RS05480	COG4974	Belongs to the 'phage' integrase family
I6I62_RS05490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I62_RS05495	COG1687	branched-chain amino acid
I6I62_RS05500	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I62_RS05505	COG0750	zinc metalloprotease
I6I62_RS05510	COG0497	DNA recombination
I6I62_RS05515	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6I62_RS05520	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I62_RS05530	COG1722	exodeoxyribonuclease VII activity
I6I62_RS05535	COG1570	exodeoxyribonuclease VII activity
I6I62_RS05540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I62_RS05555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I62_RS05590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I62_RS05605	COG2801	Transposase and inactivated derivatives
I6I62_RS05610	COG2801	Transposase and inactivated derivatives
I6I62_RS05615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I62_RS05620	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I62_RS05625	COG0768	penicillin binding
I6I62_RS05630	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS05635	COG0481	GTPase activity
I6I62_RS05645	COG2203	Gaf domain
I6I62_RS05645	COG2199	diguanylate cyclase activity
I6I62_RS05655	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I62_RS05665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I62_RS05670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I62_RS05675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I62_RS05680	COG1187	pseudouridine synthase activity
I6I62_RS05710	COG2801	Transposase and inactivated derivatives
I6I62_RS05715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I62_RS05720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I62_RS05725	COG1358	cellular component organization or biogenesis
I6I62_RS05730	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6I62_RS05735	COG0195	Participates in both transcription termination and antitermination
I6I62_RS05740	COG0779	Required for maturation of 30S ribosomal subunits
I6I62_RS05745	COG2176	DNA-directed DNA polymerase activity
I6I62_RS05755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I62_RS05760	COG4589	Belongs to the CDS family
I6I62_RS05775	COG0233	cytoplasmic translational termination
I6I62_RS05780	COG0528	UMP kinase activity
I6I62_RS05785	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I62_RS05790	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I62_RS05795	COG4974	Belongs to the 'phage' integrase family
I6I62_RS05800	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6I62_RS05805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I62_RS05810	COG0758	DNA mediated transformation
I6I62_RS05815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I62_RS05825	COG0681	Belongs to the peptidase S26 family
I6I62_RS05830	COG0335	large ribosomal subunit rRNA binding
I6I62_RS05835	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I62_RS05850	COG0228	four-way junction DNA binding
I6I62_RS05855	COG0500	methyltransferase
I6I62_RS05860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I62_RS05865	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6I62_RS05870	COG0552	protein localization to endoplasmic reticulum
I6I62_RS05875	COG1196	nuclear chromosome segregation
I6I62_RS05880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I62_RS05885	COG5002	protein histidine kinase activity
I6I62_RS05890	COG0745	RESPONSE REGULATOR receiver
I6I62_RS05900	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I62_RS05905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I62_RS05920	COG0301	tRNA thio-modification
I6I62_RS05925	COG1104	cysteine desulfurase activity
I6I62_RS05940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6I62_RS05945	COG2084	Dehydrogenase
I6I62_RS05955	COG0196	riboflavin kinase activity
I6I62_RS05960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I62_RS05965	COG0037	tRNA processing
I6I62_RS05980	COG1595	DNA-templated transcription, initiation
I6I62_RS05985	COG1609	Transcriptional regulator
I6I62_RS06015	COG0124	histidyl-tRNA synthetase
I6I62_RS06020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I62_RS06025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I62_RS06030	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6I62_RS06030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I62_RS06040	COG2244	polysaccharide biosynthetic process
I6I62_RS06045	COG0436	Aminotransferase
I6I62_RS06050	COG1126	abc transporter atp-binding protein
I6I62_RS06070	COG0561	phosphatase activity
I6I62_RS06080	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I62_RS06135	COG1132	(ABC) transporter
I6I62_RS06140	COG0704	Plays a role in the regulation of phosphate uptake
I6I62_RS06150	COG1937	Protein conserved in bacteria
I6I62_RS06160	COG0778	Nitroreductase
I6I62_RS06165	COG0784	Response regulator, receiver
I6I62_RS06165	COG3437	response regulator, receiver
I6I62_RS06200	COG1918	ferrous iron import across plasma membrane
I6I62_RS06200	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I62_RS06205	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I62_RS06205	COG1918	ferrous iron import across plasma membrane
I6I62_RS06215	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS06225	COG1136	(ABC) transporter
I6I62_RS06230	COG0577	efflux transmembrane transporter activity
I6I62_RS06240	COG0789	Transcriptional regulator
I6I62_RS06250	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I62_RS06275	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6I62_RS06280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I62_RS06285	COG2323	membrane
I6I62_RS06300	COG0572	uridine kinase
I6I62_RS06305	COG0826	peptidase U32
I6I62_RS06315	COG4122	O-methyltransferase activity
I6I62_RS06320	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6I62_RS06325	COG2706	6-phosphogluconolactonase activity
I6I62_RS06330	COG3906	Belongs to the UPF0473 family
I6I62_RS06335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I62_RS06340	COG4472	Bacterial protein of unknown function (DUF965)
I6I62_RS06350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I62_RS06355	COG0482	sulfurtransferase activity
I6I62_RS06365	COG0564	pseudouridine synthase activity
I6I62_RS06370	COG0494	nUDIX hydrolase
I6I62_RS06415	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6I62_RS06420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I62_RS06435	COG0463	Glycosyl transferase, family 2
I6I62_RS06435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I62_RS06440	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I62_RS06445	COG1134	teichoic acid transport
I6I62_RS06450	COG1682	transport, permease protein
I6I62_RS06455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I62_RS06460	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I62_RS06465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I62_RS06485	COG4656	Part of a membrane complex involved in electron transport
I6I62_RS06490	COG4658	electron transport chain
I6I62_RS06495	COG4659	FMN binding
I6I62_RS06500	COG4660	Part of a membrane complex involved in electron transport
I6I62_RS06505	COG4657	Part of a membrane complex involved in electron transport
I6I62_RS06515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I62_RS06525	COG0495	leucyl-tRNA aminoacylation
I6I62_RS06530	COG1136	(ABC) transporter
I6I62_RS06535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I62_RS06540	COG1242	4 iron, 4 sulfur cluster binding
I6I62_RS06550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I62_RS06555	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I62_RS06560	COG5001	Diguanylate cyclase
I6I62_RS06565	COG1098	S1 RNA binding domain
I6I62_RS06570	COG0166	Belongs to the GPI family
I6I62_RS06615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I62_RS06625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I62_RS06640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I62_RS06645	COG0719	Fe-S assembly protein
I6I62_RS06650	COG0396	ATPase activity
I6I62_RS06660	COG1272	protein, Hemolysin III
I6I62_RS06680	COG0537	adenosine 5'-monophosphoramidase activity
I6I62_RS06690	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6I62_RS06725	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I62_RS06725	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6I62_RS06725	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I62_RS06725	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6I62_RS06735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I62_RS06750	COG0252	asparaginase activity
I6I62_RS06755	COG0574	Belongs to the PEP-utilizing enzyme family
I6I62_RS06755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I62_RS06775	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6I62_RS06780	COG1518	maintenance of DNA repeat elements
I6I62_RS06815	COG0383	alpha-mannosidase activity
I6I62_RS06820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I62_RS06825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I62_RS06835	COG3711	transcriptional antiterminator
I6I62_RS06835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS06845	COG0494	nUDIX hydrolase
I6I62_RS06860	COG2508	Transcriptional regulator
I6I62_RS06890	COG0733	neurotransmitter:sodium symporter activity
I6I62_RS06895	COG0708	Exodeoxyribonuclease III
I6I62_RS06900	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I6I62_RS06905	COG2252	PERMEase
I6I62_RS06930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I62_RS06935	COG0534	Mate efflux family protein
I6I62_RS06945	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I62_RS06950	COG0419	ATPase involved in DNA repair
I6I62_RS06955	COG0420	3'-5' exonuclease activity
I6I62_RS06965	COG3706	GGDEF domain
I6I62_RS06975	COG1605	Chorismate mutase
I6I62_RS06975	COG0077	Prephenate dehydratase
I6I62_RS06980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I62_RS06985	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I62_RS06995	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6I62_RS07005	COG2199	diguanylate cyclase activity
I6I62_RS07005	COG2203	Gaf domain
I6I62_RS07025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I62_RS07025	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6I62_RS07035	COG2186	Transcriptional regulator
I6I62_RS07040	COG0129	dihydroxy-acid dehydratase activity
I6I62_RS07045	COG0800	Aldolase
I6I62_RS07050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I62_RS07065	COG5658	integral membrane protein
I6I62_RS07080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6I62_RS07085	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I62_RS07095	COG1940	carbohydrate kinase activity
I6I62_RS07100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I62_RS07110	COG1187	pseudouridine synthase activity
I6I62_RS07120	COG1686	Belongs to the peptidase S11 family
I6I62_RS07125	COG2715	membrane protein required for spore maturation
I6I62_RS07130	COG0700	Nucleoside recognition
I6I62_RS07135	COG0733	neurotransmitter:sodium symporter activity
I6I62_RS07145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I62_RS07155	COG0017	Asparaginyl-tRNA synthetase
I6I62_RS07160	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6I62_RS07165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I62_RS07175	COG1214	PFAM Peptidase M22, glycoprotease
I6I62_RS07180	COG0802	atpase or kinase
I6I62_RS07185	COG3557	Belongs to the UPF0374 family
I6I62_RS07190	COG3859	Proton-coupled thiamine transporter YuaJ
I6I62_RS07205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I62_RS07230	COG2239	Acts as a magnesium transporter
I6I62_RS07245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I62_RS07250	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I62_RS07255	COG3022	response to hydroperoxide
I6I62_RS07270	COG0561	phosphatase activity
I6I62_RS07295	COG0561	phosphatase activity
I6I62_RS07300	COG1929	Belongs to the glycerate kinase type-1 family
I6I62_RS07305	COG3835	regulator
I6I62_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
I6I62_RS07320	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I62_RS07335	COG0588	phosphoglycerate mutase activity
I6I62_RS07345	COG1132	(ABC) transporter
I6I62_RS07345	COG2375	cellular response to nickel ion
I6I62_RS07350	COG1132	(ABC) transporter
I6I62_RS07370	COG1132	(ABC) transporter
I6I62_RS07375	COG1132	(ABC) transporter
I6I62_RS07375	COG2375	cellular response to nickel ion
I6I62_RS07390	COG1136	(ABC) transporter
I6I62_RS07395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I62_RS07400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I62_RS07405	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6I62_RS07410	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS07455	COG0110	maltose O-acetyltransferase activity
I6I62_RS07475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I62_RS07505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I62_RS07510	COG0154	amidase activity
I6I62_RS07525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I62_RS07530	COG0210	DNA helicase
I6I62_RS07545	COG0167	dihydroorotate dehydrogenase activity
I6I62_RS07550	COG0543	2 iron, 2 sulfur cluster binding
I6I62_RS07560	COG0540	Belongs to the ATCase OTCase family
I6I62_RS07565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I62_RS07570	COG0742	ribosomal rna small subunit methyltransferase
I6I62_RS07590	COG0772	Belongs to the SEDS family
I6I62_RS07620	COG2873	o-acetylhomoserine
I6I62_RS07625	COG0004	ammonium transporteR
I6I62_RS07630	COG0347	Belongs to the P(II) protein family
I6I62_RS07645	COG0205	6-phosphofructokinase activity
I6I62_RS07650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I62_RS07655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I62_RS07665	COG1959	2 iron, 2 sulfur cluster binding
I6I62_RS07675	COG2183	response to ionizing radiation
I6I62_RS07685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I62_RS07725	COG5290	Psort location Cytoplasmic, score
I6I62_RS07745	COG2340	Cysteine-rich secretory protein family
I6I62_RS07760	COG1595	DNA-templated transcription, initiation
I6I62_RS07780	COG0791	NLP P60 protein
I6I62_RS07815	COG0515	serine threonine protein kinase
I6I62_RS07905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I62_RS07940	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS07945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS07950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I62_RS07955	COG1882	Formate acetyltransferase
I6I62_RS07960	COG4977	sequence-specific DNA binding
I6I62_RS07970	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I62_RS07975	COG0363	glucosamine-6-phosphate deaminase activity
I6I62_RS07980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I62_RS08000	COG1490	D-aminoacyl-tRNA deacylase activity
I6I62_RS08005	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I62_RS08010	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I62_RS08015	COG3620	sequence-specific DNA binding
I6I62_RS08020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I62_RS08025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I62_RS08030	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I62_RS08040	COG0516	GMP reductase activity
I6I62_RS08040	COG0517	IMP dehydrogenase activity
I6I62_RS08050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I62_RS08060	COG2359	stage V sporulation protein S
I6I62_RS08065	COG1692	metallophosphoesterase
I6I62_RS08080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I62_RS08085	COG1546	Belongs to the CinA family
I6I62_RS08085	COG1058	Belongs to the CinA family
I6I62_RS08090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I62_RS08100	COG1454	alcohol dehydrogenase
I6I62_RS08130	COG1396	sequence-specific DNA binding
I6I62_RS08140	COG3331	DNA recombination
I6I62_RS08145	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6I62_RS08145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I62_RS08150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I62_RS08155	COG3935	DnaD domain protein
I6I62_RS08165	COG2738	Putative neutral zinc metallopeptidase
I6I62_RS08175	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6I62_RS08180	COG2169	Transcriptional regulator
I6I62_RS08185	COG1592	Rubrerythrin
I6I62_RS08195	COG2211	Major facilitator Superfamily
I6I62_RS08205	COG0436	Aminotransferase
I6I62_RS08225	COG0469	pyruvate kinase activity
I6I62_RS08235	COG0534	Mate efflux family protein
I6I62_RS08255	COG1940	carbohydrate kinase activity
I6I62_RS08260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I62_RS08265	COG2017	converts alpha-aldose to the beta-anomer
I6I62_RS08270	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6I62_RS08275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I62_RS08280	COG1609	Transcriptional regulator
I6I62_RS08285	COG0783	Belongs to the Dps family
I6I62_RS08290	COG0450	alkyl hydroperoxide reductase
I6I62_RS08300	COG0768	penicillin binding
I6I62_RS08305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I62_RS08345	COG1323	Belongs to the UPF0348 family
I6I62_RS08370	COG0072	phenylalanine-tRNA ligase activity
I6I62_RS08370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I62_RS08375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I62_RS08385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I62_RS08410	COG0469	pyruvate kinase activity
I6I62_RS08425	COG3611	Membrane attachment protein
I6I62_RS08430	COG0237	dephospho-CoA kinase activity
I6I62_RS08440	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I62_RS08445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I62_RS08445	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I62_RS08450	COG0587	DNA-directed DNA polymerase activity
I6I62_RS08465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I62_RS08470	COG4536	flavin adenine dinucleotide binding
I6I62_RS08475	COG0768	penicillin binding
I6I62_RS08480	COG0768	penicillin binding
I6I62_RS08490	COG0275	rRNA processing
I6I62_RS08500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I62_RS08505	COG1399	metal-binding, possibly nucleic acid-binding protein
I6I62_RS08525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I62_RS08545	COG1396	sequence-specific DNA binding
I6I62_RS08550	COG1803	Methylglyoxal synthase
I6I62_RS08565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I62_RS08570	COG5002	protein histidine kinase activity
I6I62_RS08575	COG0745	RESPONSE REGULATOR receiver
I6I62_RS08580	COG1702	phosphate starvation-inducible protein PhoH
I6I62_RS08595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6I62_RS08600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6I62_RS08605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I62_RS08620	COG0561	phosphatase activity
I6I62_RS08630	COG0656	L-ascorbic acid biosynthetic process
I6I62_RS08725	COG3103	Sh3 type 3 domain protein
I6I62_RS08725	COG1388	LysM domain
I6I62_RS08725	COG0791	NLP P60 protein
I6I62_RS08735	COG1674	ftsk spoiiie
I6I62_RS08735	COG0433	COG0433 Predicted ATPase
I6I62_RS08780	COG0582	viral genome integration into host DNA
I6I62_RS08825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS08830	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I62_RS08835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS08835	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS08845	COG3711	transcriptional antiterminator
I6I62_RS08845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS08850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I62_RS08855	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS08860	COG1482	cell wall glycoprotein biosynthetic process
I6I62_RS08865	COG3711	transcriptional antiterminator
I6I62_RS08865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS08935	COG1192	Involved in chromosome partitioning
I6I62_RS08985	COG3328	transposase activity
I6I62_RS09015	COG0561	phosphatase activity
I6I62_RS09025	COG1309	transcriptional regulator
I6I62_RS09030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I62_RS09040	COG1074	ATP-dependent DNA helicase activity
I6I62_RS09050	COG3022	response to hydroperoxide
I6I62_RS09060	COG0561	phosphatase activity
I6I62_RS09085	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I62_RS09110	COG1335	isochorismatase
I6I62_RS09125	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I62_RS09130	COG3142	Participates in the control of copper homeostasis
I6I62_RS09150	COG1132	(ABC) transporter
I6I62_RS09160	COG3588	fructose-bisphosphate aldolase
I6I62_RS09180	COG3716	PTS system mannose fructose sorbose family IID component
I6I62_RS09185	COG3715	PTS system
I6I62_RS09200	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS09205	COG2190	(PTS) system
I6I62_RS09205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS09205	COG1263	PTS System
I6I62_RS09215	COG0583	DNA-binding transcription factor activity
I6I62_RS09250	COG0667	Aldo Keto reductase
I6I62_RS09305	COG1086	Polysaccharide biosynthesis protein
I6I62_RS09335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I62_RS09340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I62_RS09365	COG1882	Formate acetyltransferase
I6I62_RS09395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I62_RS09430	COG0789	Transcriptional regulator
I6I62_RS09440	COG0667	Aldo Keto reductase
I6I62_RS09445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I62_RS09455	COG1136	(ABC) transporter
I6I62_RS09465	COG0789	Transcriptional regulator
I6I62_RS09480	COG0628	permease
I6I62_RS09490	COG0671	phosphoesterase, PA-phosphatase related
I6I62_RS09495	COG1045	serine acetyltransferase
I6I62_RS09500	COG1215	transferase activity, transferring glycosyl groups
I6I62_RS09510	COG0436	Aminotransferase
I6I62_RS09525	COG4608	Belongs to the ABC transporter superfamily
I6I62_RS09530	COG0444	Belongs to the ABC transporter superfamily
I6I62_RS09535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I62_RS09540	COG0601	transmembrane transport
I6I62_RS09545	COG1525	nuclease
I6I62_RS09560	COG1597	lipid kinase activity
I6I62_RS09565	COG1621	beta-fructofuranosidase activity
I6I62_RS09595	COG1940	carbohydrate kinase activity
I6I62_RS09600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I62_RS09610	COG3711	transcriptional antiterminator
I6I62_RS09615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I62_RS09620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I62_RS09625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I62_RS09635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I62_RS09650	COG1592	Rubrerythrin
I6I62_RS09650	COG1773	rubredoxin
I6I62_RS09660	COG3711	transcriptional antiterminator
I6I62_RS09665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS09665	COG1263	PTS System
I6I62_RS09665	COG2190	(PTS) system
I6I62_RS09670	COG2190	(PTS) system
I6I62_RS09680	COG1564	THIamine pyrophosphokinase
I6I62_RS09685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I62_RS09690	COG1162	GTPase activity
I6I62_RS09695	COG0515	serine threonine protein kinase
I6I62_RS09695	COG2815	serine threonine protein kinase
I6I62_RS09700	COG0631	protein serine/threonine phosphatase activity
I6I62_RS09705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I62_RS09710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I62_RS09710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I62_RS09715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I62_RS09745	COG0194	GDP metabolic process
I6I62_RS09760	COG1496	oxidoreductase activity
I6I62_RS09765	COG2202	Pas domain
I6I62_RS09765	COG2199	diguanylate cyclase activity
I6I62_RS09765	COG2200	EAL domain
I6I62_RS09770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I62_RS09770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I62_RS09820	COG2304	oxidoreductase activity
I6I62_RS09850	COG0791	NLP P60 protein
I6I62_RS09850	COG1388	LysM domain
I6I62_RS09875	COG1136	(ABC) transporter
I6I62_RS09895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I62_RS09910	COG0564	pseudouridine synthase activity
I6I62_RS09920	COG2217	Heavy metal translocating P-type atpase
I6I62_RS09935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I62_RS09945	COG2309	aminopeptidase activity
I6I62_RS09955	COG2190	(PTS) system
I6I62_RS09955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS09955	COG1263	PTS System
I6I62_RS09960	COG0772	Belongs to the SEDS family
I6I62_RS09965	COG0564	pseudouridine synthase activity
I6I62_RS09980	COG1393	Belongs to the ArsC family
I6I62_RS09985	COG1725	Transcriptional regulator
I6I62_RS09995	COG1131	(ABC) transporter
I6I62_RS10025	COG0251	oxidation-reduction process
I6I62_RS10030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I62_RS10035	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6I62_RS10040	COG1268	BioY protein
I6I62_RS10045	COG0534	Mate efflux family protein
I6I62_RS10050	COG3394	polysaccharide catabolic process
I6I62_RS10065	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS10070	COG2190	(PTS) system
I6I62_RS10070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS10070	COG1263	PTS System
I6I62_RS10075	COG3711	transcriptional antiterminator
I6I62_RS10080	COG0726	polysaccharide deacetylase
I6I62_RS10085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I62_RS10095	COG2720	vancomycin resistance protein
I6I62_RS10120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I62_RS10120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I62_RS10120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS10125	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I62_RS10135	COG4977	sequence-specific DNA binding
I6I62_RS10140	COG0235	Class ii aldolase
I6I62_RS10145	COG4806	L-rhamnose isomerase
I6I62_RS10150	COG1070	Carbohydrate kinase
I6I62_RS10170	COG2207	Transcriptional regulator
I6I62_RS10170	COG1609	Transcriptional regulator
I6I62_RS10180	COG3250	beta-galactosidase activity
I6I62_RS10185	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS10200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS10210	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS10215	COG1737	Transcriptional regulator
I6I62_RS10230	COG1773	rubredoxin
I6I62_RS10230	COG0426	domain, Protein
I6I62_RS10245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
I6I62_RS10255	COG3192	ethanolamine utilization protein
I6I62_RS10275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I62_RS10280	COG0366	Alpha amylase catalytic
I6I62_RS10285	COG2169	Transcriptional regulator
I6I62_RS10290	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I62_RS10300	COG1136	(ABC) transporter
I6I62_RS10330	COG1131	(ABC) transporter
I6I62_RS10375	COG0534	Mate efflux family protein
I6I62_RS10380	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I62_RS10405	COG0659	secondary active sulfate transmembrane transporter activity
I6I62_RS10410	COG0583	DNA-binding transcription factor activity
I6I62_RS10420	COG2059	Chromate
I6I62_RS10425	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I62_RS10430	COG5492	domain, Protein
I6I62_RS10440	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS10445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I62_RS10470	COG0673	inositol 2-dehydrogenase activity
I6I62_RS10500	COG0602	queuosine metabolic process
I6I62_RS10510	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I62_RS10515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I62_RS10520	COG1063	alcohol dehydrogenase
I6I62_RS10550	COG1125	glycine betaine transport
I6I62_RS10560	COG0259	pyridoxamine-phosphate oxidase activity
I6I62_RS10565	COG2135	peptidase activity
I6I62_RS10575	COG0519	Catalyzes the synthesis of GMP from XMP
I6I62_RS10620	COG2801	Transposase and inactivated derivatives
I6I62_RS10630	COG0463	Glycosyl transferase, family 2
I6I62_RS10635	COG0488	(ABC) transporter
I6I62_RS10645	COG0656	L-ascorbic acid biosynthetic process
I6I62_RS10660	COG3708	Transcriptional regulator
I6I62_RS10660	COG2207	Transcriptional regulator
I6I62_RS10670	COG3878	Protein conserved in bacteria
I6I62_RS10695	COG1272	protein, Hemolysin III
I6I62_RS10705	COG0454	-acetyltransferase
I6I62_RS10715	COG0242	peptide deformylase activity
I6I62_RS10725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6I62_RS10735	COG1321	iron dependent repressor
I6I62_RS10745	COG0789	Transcriptional regulator
I6I62_RS10750	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS10760	COG0667	Aldo Keto reductase
I6I62_RS10770	COG0656	L-ascorbic acid biosynthetic process
I6I62_RS10775	COG0656	L-ascorbic acid biosynthetic process
I6I62_RS10780	COG0656	L-ascorbic acid biosynthetic process
I6I62_RS10785	COG3706	GGDEF domain
I6I62_RS10810	COG0383	alpha-mannosidase activity
I6I62_RS10815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I62_RS10815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I62_RS10815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS10830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I62_RS10835	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
I6I62_RS10840	COG1876	peptidase activity
I6I62_RS10855	COG1876	peptidase activity
I6I62_RS10865	COG0561	phosphatase activity
I6I62_RS10890	COG1187	pseudouridine synthase activity
I6I62_RS10910	COG1869	D-ribose catabolic process
I6I62_RS10920	COG0300	oxidoreductase activity
I6I62_RS10930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS10960	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I62_RS10965	COG1846	Transcriptional regulator
I6I62_RS10990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I62_RS10995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I62_RS11005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I62_RS11010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I62_RS11015	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I62_RS11015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS11015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I62_RS11030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS11030	COG1263	PTS System
I6I62_RS11030	COG2190	(PTS) system
I6I62_RS11035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS11035	COG1263	PTS System
I6I62_RS11045	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS11065	COG0673	inositol 2-dehydrogenase activity
I6I62_RS11070	COG0673	inositol 2-dehydrogenase activity
I6I62_RS11075	COG1811	Na channel or pump
I6I62_RS11080	COG0523	cobalamin synthesis protein
I6I62_RS11095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS11095	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS11105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS11105	COG2213	PTS system mannitol-specific
I6I62_RS11110	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I62_RS11110	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I62_RS11140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS11155	COG1940	carbohydrate kinase activity
I6I62_RS11160	COG2508	Transcriptional regulator
I6I62_RS11165	COG1902	pentaerythritol trinitrate reductase activity
I6I62_RS11165	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I62_RS11170	COG0789	Transcriptional regulator
I6I62_RS11175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I62_RS11180	COG0626	cystathionine gamma-synthase activity
I6I62_RS11195	COG2011	ABC-type metal ion transport system permease component
I6I62_RS11200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I62_RS11205	COG1473	amidohydrolase
I6I62_RS11215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I62_RS11220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I62_RS11230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6I62_RS11245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I62_RS11255	COG0825	malonyl-CoA metabolic process
I6I62_RS11260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I62_RS11265	COG0439	Biotin carboxylase
I6I62_RS11275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I62_RS11300	COG2267	carboxylic ester hydrolase activity
I6I62_RS11315	COG0791	NLP P60 protein
I6I62_RS11330	COG3300	MHYT domain
I6I62_RS11330	COG5001	Diguanylate cyclase
I6I62_RS11340	COG1346	cytolysis
I6I62_RS11365	COG2801	Transposase and inactivated derivatives
I6I62_RS11390	COG2205	protein histidine kinase activity
I6I62_RS11400	COG0398	Pfam SNARE associated Golgi protein
I6I62_RS11405	COG3343	RNA polymerase activity
I6I62_RS11410	COG0018	arginyl-trna synthetase
I6I62_RS11415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I62_RS11425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I62_RS11430	COG1078	dGTPase activity
I6I62_RS11480	COG2856	Zn peptidase
I6I62_RS11505	COG1486	melibiose metabolic process
I6I62_RS11530	COG3279	Response regulator of the LytR AlgR family
I6I62_RS11535	COG1802	Transcriptional regulator
I6I62_RS11540	COG0473	3-isopropylmalate dehydrogenase activity
I6I62_RS11550	COG0488	(ABC) transporter
I6I62_RS11570	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS11580	COG5002	protein histidine kinase activity
I6I62_RS11585	COG0745	RESPONSE REGULATOR receiver
I6I62_RS11600	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I62_RS11610	COG0004	ammonium transporteR
I6I62_RS11625	COG1115	amino acid carrier protein
I6I62_RS11675	COG1737	Transcriptional regulator
I6I62_RS11700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS11705	COG2188	Transcriptional regulator
I6I62_RS11715	COG0622	Phosphoesterase
I6I62_RS11730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I62_RS11740	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I62_RS11765	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I62_RS11780	COG0534	Mate efflux family protein
I6I62_RS11785	COG0254	rRNA binding
I6I62_RS11790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I62_RS11800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6I62_RS11805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I62_RS11815	COG1247	-acetyltransferase
I6I62_RS11825	COG1408	metallophosphoesterase
I6I62_RS11830	COG1408	metallophosphoesterase
I6I62_RS11835	COG2226	methyltransferase
I6I62_RS11840	COG3326	Membrane
I6I62_RS11855	COG2843	Capsule synthesis protein
I6I62_RS11860	COG1876	peptidase activity
I6I62_RS11870	COG1136	(ABC) transporter
I6I62_RS11895	COG0383	alpha-mannosidase activity
I6I62_RS11900	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS11910	COG4481	Protein conserved in bacteria
I6I62_RS11920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I62_RS11930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I62_RS11935	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I62_RS11940	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I62_RS11940	COG0037	tRNA processing
I6I62_RS11945	COG0513	Belongs to the DEAD box helicase family
I6I62_RS11965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I62_RS11975	COG1132	(ABC) transporter
I6I62_RS11980	COG4988	ABC transporter
I6I62_RS11985	COG2832	Protein of unknown function (DUF454)
I6I62_RS12005	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS12015	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I62_RS12020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I62_RS12025	COG1435	thymidine kinase activity
I6I62_RS12030	COG0305	Participates in initiation and elongation during chromosome replication
I6I62_RS12035	COG0359	binds to the 23S rRNA
I6I62_RS12040	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6I62_RS12050	COG2199	diguanylate cyclase activity
I6I62_RS12050	COG2203	Gaf domain
I6I62_RS12055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I62_RS12060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I62_RS12070	COG0789	Transcriptional regulator
I6I62_RS12070	COG4978	Transcriptional regulator
I6I62_RS12075	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS12090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS12105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS12110	COG0673	inositol 2-dehydrogenase activity
I6I62_RS12120	COG0534	Mate efflux family protein
I6I62_RS12140	COG1475	DNA binding
I6I62_RS12145	COG1192	Involved in chromosome partitioning
I6I62_RS12150	COG0688	phosphatidylethanolamine metabolic process
I6I62_RS12155	COG1183	phosphatidylcholine synthase activity
I6I62_RS12160	COG2190	(PTS) system
I6I62_RS12160	COG1263	PTS System
I6I62_RS12160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS12165	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS12175	COG0602	queuosine metabolic process
I6I62_RS12180	COG1328	CTP reductase activity
I6I62_RS12210	COG0534	Mate efflux family protein
I6I62_RS12230	COG1695	Transcriptional regulator
I6I62_RS12280	COG0463	Glycosyl transferase, family 2
I6I62_RS12295	COG0745	RESPONSE REGULATOR receiver
I6I62_RS12300	COG0642	Histidine kinase
I6I62_RS12300	COG5002	protein histidine kinase activity
I6I62_RS12305	COG0756	dUTP diphosphatase activity
I6I62_RS12325	COG2801	Transposase and inactivated derivatives
I6I62_RS12335	COG2205	protein histidine kinase activity
I6I62_RS12345	COG1131	(ABC) transporter
I6I62_RS12350	COG0745	RESPONSE REGULATOR receiver
I6I62_RS12355	COG1132	(ABC) transporter
I6I62_RS12360	COG1132	(ABC) transporter
I6I62_RS12370	COG3394	polysaccharide catabolic process
I6I62_RS12375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS12380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS12380	COG3711	transcriptional antiterminator
I6I62_RS12385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS12395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I62_RS12415	COG1393	Belongs to the ArsC family
I6I62_RS12430	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I62_RS12470	COG0084	hydrolase, TatD family'
I6I62_RS12475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I62_RS12480	COG0569	domain protein
I6I62_RS12520	COG1120	ATPase activity
I6I62_RS12525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I62_RS12530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I62_RS12535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I62_RS12550	COG0583	DNA-binding transcription factor activity
I6I62_RS12570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I62_RS12575	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I62_RS12590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I62_RS12605	COG0534	Mate efflux family protein
I6I62_RS12630	COG1660	Displays ATPase and GTPase activities
I6I62_RS12640	COG2268	Band 7 protein
I6I62_RS12655	COG1648	precorrin-2 dehydrogenase activity
I6I62_RS12655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I62_RS12660	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I62_RS12665	COG0113	porphobilinogen synthase activity
I6I62_RS12675	COG0181	hydroxymethylbilane synthase activity
I6I62_RS12680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I62_RS12700	COG0583	DNA-binding transcription factor activity
I6I62_RS12705	COG0492	ferredoxin-NADP+ reductase activity
I6I62_RS12715	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I62_RS12720	COG2169	Transcriptional regulator
I6I62_RS12740	COG3191	aminopeptidase activity
I6I62_RS12750	COG0561	phosphatase activity
I6I62_RS12755	COG1132	(ABC) transporter
I6I62_RS12765	COG2205	protein histidine kinase activity
I6I62_RS12780	COG3716	PTS system mannose fructose sorbose family IID component
I6I62_RS12785	COG3715	PTS system
I6I62_RS12795	COG3711	transcriptional antiterminator
I6I62_RS12800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS12800	COG1263	PTS System
I6I62_RS12800	COG2190	(PTS) system
I6I62_RS12810	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS12815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS12820	COG2188	Transcriptional regulator
I6I62_RS12825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I62_RS12830	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6I62_RS12835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I62_RS12840	COG0617	tRNA 3'-terminal CCA addition
I6I62_RS12845	COG0556	nucleotide-excision repair
I6I62_RS12850	COG3409	Peptidoglycan-binding domain 1 protein
I6I62_RS12850	COG0793	Belongs to the peptidase S41A family
I6I62_RS12855	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I62_RS12870	COG0561	phosphatase activity
I6I62_RS12885	COG0010	Belongs to the arginase family
I6I62_RS12890	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6I62_RS12895	COG1982	Orn Lys Arg decarboxylase major
I6I62_RS12905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I62_RS12910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I62_RS12915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I62_RS12920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I62_RS12925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I62_RS12935	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I62_RS12955	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I62_RS12960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I62_RS12965	COG0698	ribose 5-phosphate isomerase
I6I62_RS12970	COG0009	L-threonylcarbamoyladenylate synthase
I6I62_RS13030	COG1368	sulfuric ester hydrolase activity
I6I62_RS13045	COG0463	Glycosyl transferase, family 2
I6I62_RS13050	COG0297	glycogen (starch) synthase activity
I6I62_RS13065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I62_RS13090	COG3754	Rhamnan synthesis protein F
I6I62_RS13095	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6I62_RS13110	COG3328	transposase activity
I6I62_RS13120	COG4193	domain, Protein
I6I62_RS13120	COG5263	repeat protein
I6I62_RS13140	COG2801	Transposase and inactivated derivatives
I6I62_RS13145	COG0562	UDP-galactopyranose mutase
I6I62_RS13155	COG0438	transferase activity, transferring glycosyl groups
I6I62_RS13160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I62_RS13175	COG0463	Glycosyl transferase, family 2
I6I62_RS13195	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I62_RS13260	COG2801	Transposase and inactivated derivatives
I6I62_RS13270	COG2801	Transposase and inactivated derivatives
I6I62_RS13290	COG4978	Transcriptional regulator
I6I62_RS13290	COG0789	Transcriptional regulator
I6I62_RS13295	COG1737	Transcriptional regulator
I6I62_RS13305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS13310	COG0363	glucosamine-6-phosphate deaminase activity
I6I62_RS13315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I62_RS13350	COG1316	TRANSCRIPTIONal
I6I62_RS13390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS13390	COG3711	transcriptional antiterminator
I6I62_RS13395	COG4821	SIS domain
I6I62_RS13400	COG4821	SIS domain
I6I62_RS13405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I62_RS13410	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I6I62_RS13415	COG5001	Diguanylate cyclase
I6I62_RS13425	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6I62_RS13435	COG5012	cobalamin binding
I6I62_RS13450	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I62_RS13465	COG2188	Transcriptional regulator
I6I62_RS13475	COG2357	RelA SpoT domain protein
I6I62_RS13480	COG0726	polysaccharide deacetylase
I6I62_RS13485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I62_RS13490	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I62_RS13495	COG1774	PSP1 C-terminal conserved region
I6I62_RS13500	COG0470	DNA polymerase III
I6I62_RS13505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I62_RS13520	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I62_RS13525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I62_RS13555	COG1131	(ABC) transporter
I6I62_RS13585	COG0561	phosphatase activity
I6I62_RS13590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I62_RS13600	COG1136	(ABC) transporter
I6I62_RS13610	COG5001	Diguanylate cyclase
I6I62_RS13610	COG3300	MHYT domain
I6I62_RS13615	COG1757	Na H antiporter
I6I62_RS13645	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I62_RS13650	COG0187	DNA topoisomerase II activity
I6I62_RS13655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I62_RS13665	COG0592	DNA-directed DNA polymerase activity
I6I62_RS13670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I62_RS13675	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I62_RS13680	COG0594	ribonuclease P activity
I6I62_RS13705	COG0789	Transcriptional regulator
I6I62_RS13715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I62_RS13725	COG1486	melibiose metabolic process
I6I62_RS13730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS13730	COG1263	PTS System
I6I62_RS13740	COG1737	Transcriptional regulator
I6I62_RS13745	COG2190	(PTS) system
I6I62_RS13750	COG3279	Response regulator of the LytR AlgR family
I6I62_RS13770	COG0673	inositol 2-dehydrogenase activity
I6I62_RS13785	COG0668	transmembrane transport
I6I62_RS13800	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS13810	COG0534	Mate efflux family protein
I6I62_RS13815	COG1253	flavin adenine dinucleotide binding
I6I62_RS13875	COG2205	protein histidine kinase activity
I6I62_RS13880	COG0745	RESPONSE REGULATOR receiver
I6I62_RS13885	COG2205	protein histidine kinase activity
I6I62_RS13890	COG0745	RESPONSE REGULATOR receiver
I6I62_RS13910	COG2270	Major facilitator Superfamily
I6I62_RS13925	COG1393	Belongs to the ArsC family
I6I62_RS13930	COG3711	transcriptional antiterminator
I6I62_RS13930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS13940	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I62_RS13945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS13950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS13960	COG1446	asparaginase
I6I62_RS13965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I62_RS13970	COG3142	Participates in the control of copper homeostasis
I6I62_RS13975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I62_RS14065	COG0791	NLP P60 protein
I6I62_RS14065	COG0741	lytic transglycosylase activity
I6I62_RS14105	COG0085	RNA polymerase activity
I6I62_RS14120	COG2946	Replication initiation factor
I6I62_RS14125	COG1674	ftsk spoiiie
I6I62_RS14150	COG5001	Diguanylate cyclase
I6I62_RS14155	COG1737	Transcriptional regulator
I6I62_RS14160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS14170	COG2239	Acts as a magnesium transporter
I6I62_RS14190	COG0745	RESPONSE REGULATOR receiver
I6I62_RS14195	COG5002	protein histidine kinase activity
I6I62_RS14200	COG1136	(ABC) transporter
I6I62_RS14205	COG0577	efflux transmembrane transporter activity
I6I62_RS14210	COG0110	maltose O-acetyltransferase activity
I6I62_RS14225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I62_RS14230	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I62_RS14235	COG0019	diaminopimelate decarboxylase activity
I6I62_RS14255	COG0583	DNA-binding transcription factor activity
I6I62_RS14270	COG2357	RelA SpoT domain protein
I6I62_RS14280	COG3300	MHYT domain
I6I62_RS14280	COG5001	Diguanylate cyclase
I6I62_RS14285	COG0542	response to heat
I6I62_RS14290	COG0586	Pfam SNARE associated Golgi protein
I6I62_RS14300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I62_RS14315	COG0629	single-stranded DNA binding
I6I62_RS14320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I62_RS14325	COG1349	DNA-binding transcription factor activity
I6I62_RS14335	COG3959	Transketolase, thiamine diphosphate binding domain
I6I62_RS14340	COG3958	Transketolase
I6I62_RS14345	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS14350	COG0205	6-phosphofructokinase activity
I6I62_RS14355	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6I62_RS14395	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I6I62_RS14405	COG1115	amino acid carrier protein
I6I62_RS14410	COG5001	Diguanylate cyclase
I6I62_RS14410	COG3300	MHYT domain
I6I62_RS14415	COG0351	phosphomethylpyrimidine kinase
I6I62_RS14420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I62_RS14430	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I62_RS14435	COG2081	HI0933 family
I6I62_RS14470	COG0640	Transcriptional regulator
I6I62_RS14485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I62_RS14500	COG0667	Aldo Keto reductase
I6I62_RS14510	COG2315	Protein conserved in bacteria
I6I62_RS14520	COG1151	hydroxylamine reductase activity
I6I62_RS14535	COG5001	Diguanylate cyclase
I6I62_RS14540	COG0363	glucosamine-6-phosphate deaminase activity
I6I62_RS14550	COG0205	6-phosphofructokinase activity
I6I62_RS14570	COG1733	regulation of RNA biosynthetic process
I6I62_RS14580	COG0366	Alpha amylase catalytic
I6I62_RS14620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS14630	COG3620	sequence-specific DNA binding
I6I62_RS14675	COG1737	Transcriptional regulator
I6I62_RS14680	COG1486	melibiose metabolic process
I6I62_RS14685	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS14695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS14700	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I62_RS14705	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS14710	COG2190	(PTS) system
I6I62_RS14710	COG1263	PTS System
I6I62_RS14710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS14715	COG1342	Belongs to the UPF0251 family
I6I62_RS14725	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I6I62_RS14730	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS14745	COG1733	regulation of RNA biosynthetic process
I6I62_RS14750	COG4978	Transcriptional regulator
I6I62_RS14750	COG0789	Transcriptional regulator
I6I62_RS14760	COG0584	glycerophosphoryl diester phosphodiesterase
I6I62_RS14765	COG0745	RESPONSE REGULATOR receiver
I6I62_RS14770	COG2205	protein histidine kinase activity
I6I62_RS14775	COG1136	(ABC) transporter
I6I62_RS14790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I62_RS14830	COG0789	Transcriptional regulator
I6I62_RS14835	COG1132	(ABC) transporter
I6I62_RS14840	COG1132	(ABC) transporter
I6I62_RS14845	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I6I62_RS14845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6I62_RS14850	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I62_RS14870	COG1966	Carbon starvation protein
I6I62_RS14895	COG0012	GTP binding
I6I62_RS14900	COG4509	Sortase family
I6I62_RS14905	COG1316	TRANSCRIPTIONal
I6I62_RS14935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS14940	COG1414	Transcriptional regulator
I6I62_RS14950	COG1414	Transcriptional regulator
I6I62_RS14955	COG1312	Catalyzes the dehydration of D-mannonate
I6I62_RS14960	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS14965	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS14975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I62_RS14985	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS14990	COG0698	ribose 5-phosphate isomerase
I6I62_RS14995	COG3711	transcriptional antiterminator
I6I62_RS14995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS15000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS15015	COG1482	cell wall glycoprotein biosynthetic process
I6I62_RS15020	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS15035	COG1737	Transcriptional regulator
I6I62_RS15045	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS15050	COG0673	inositol 2-dehydrogenase activity
I6I62_RS15055	COG0673	inositol 2-dehydrogenase activity
I6I62_RS15065	COG1408	metallophosphoesterase
I6I62_RS15070	COG0024	Methionine aminopeptidase
I6I62_RS15085	COG0673	inositol 2-dehydrogenase activity
I6I62_RS15100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I62_RS15105	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I62_RS15120	COG1131	(ABC) transporter
I6I62_RS15140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I62_RS15155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I62_RS15160	COG0066	3-isopropylmalate dehydratase activity
I6I62_RS15165	COG0473	3-isopropylmalate dehydrogenase activity
I6I62_RS15175	COG0028	Belongs to the TPP enzyme family
I6I62_RS15190	COG4716	Myosin-crossreactive antigen
I6I62_RS15245	COG3344	reverse transcriptase
I6I62_RS15255	COG1174	glycine betaine transport
I6I62_RS15270	COG0126	phosphoglycerate kinase activity
I6I62_RS15280	COG2033	superoxide reductase activity
I6I62_RS15285	COG1028	Short-chain dehydrogenase reductase Sdr
I6I62_RS15290	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I62_RS15295	COG0081	regulation of translation
I6I62_RS15300	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I62_RS15305	COG0222	ribosome binding
I6I62_RS15310	COG2813	Specifically methylates the guanine in position
I6I62_RS15315	COG0085	RNA polymerase activity
I6I62_RS15320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I62_RS15340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I62_RS15345	COG0049	tRNA binding
I6I62_RS15350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I62_RS15360	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I62_RS15415	COG0406	alpha-ribazole phosphatase activity
I6I62_RS15420	COG0051	transcription antitermination factor activity, RNA binding
I6I62_RS15425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I62_RS15435	COG0089	rRNA binding
I6I62_RS15440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I62_RS15445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I62_RS15450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I62_RS15455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I62_RS15470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I62_RS15475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I62_RS15485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I62_RS15490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I62_RS15495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I62_RS15500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I62_RS15505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I62_RS15510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I62_RS15515	COG1841	ribosomal large subunit assembly
I6I62_RS15525	COG0201	protein transport
I6I62_RS15530	COG0563	adenylate kinase activity
I6I62_RS15535	COG0024	Methionine aminopeptidase
I6I62_RS15540	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I62_RS15550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I62_RS15555	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I62_RS15560	COG0202	RNA polymerase activity
I6I62_RS15575	COG1122	ATPase activity
I6I62_RS15580	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I62_RS15585	COG0101	tRNA pseudouridine synthase activity
I6I62_RS15600	COG1073	alpha beta
I6I62_RS15605	COG2203	Gaf domain
I6I62_RS15605	COG2199	diguanylate cyclase activity
I6I62_RS15610	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS15615	COG1737	Transcriptional regulator
I6I62_RS15630	COG1285	pathogenesis
I6I62_RS15650	COG4869	propanediol catabolic process
I6I62_RS15655	COG0070	glutamate synthase
I6I62_RS15655	COG0067	glutamate synthase
I6I62_RS15655	COG0069	glutamate synthase activity
I6I62_RS15660	COG0493	'glutamate synthase
I6I62_RS15665	COG1528	Iron-storage protein
I6I62_RS15685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I62_RS15690	COG0745	RESPONSE REGULATOR receiver
I6I62_RS15695	COG2205	protein histidine kinase activity
I6I62_RS15695	COG2770	Histidine kinase
I6I62_RS15700	COG0583	DNA-binding transcription factor activity
I6I62_RS15715	COG0534	Mate efflux family protein
I6I62_RS15720	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS15735	COG3290	protein histidine kinase activity
I6I62_RS15750	COG0484	heat shock protein binding
I6I62_RS15755	COG0443	Heat shock 70 kDa protein
I6I62_RS15760	COG0288	reversible hydration of carbon dioxide
I6I62_RS15765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6I62_RS15775	COG0157	Belongs to the NadC ModD family
I6I62_RS15780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I62_RS15805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I62_RS15820	COG3279	Response regulator of the LytR AlgR family
I6I62_RS15835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6I62_RS15835	COG0493	'glutamate synthase
I6I62_RS15855	COG3620	sequence-specific DNA binding
I6I62_RS15875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I62_RS15880	COG3064	Membrane
I6I62_RS15880	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6I62_RS15880	COG3583	domain protein
I6I62_RS15895	COG1362	aminopeptidase activity
I6I62_RS15900	COG0534	Mate efflux family protein
I6I62_RS15905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6I62_RS15905	COG0456	acetyltransferase
I6I62_RS15930	COG0561	phosphatase activity
I6I62_RS15935	COG0561	phosphatase activity
I6I62_RS15940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I62_RS15945	COG0285	dihydrofolate synthase activity
I6I62_RS15955	COG0367	asparagine synthase
I6I62_RS15965	COG3773	Cell wall hydrolase
I6I62_RS15985	COG0561	phosphatase activity
I6I62_RS15995	COG0215	cysteine-tRNA ligase activity
I6I62_RS16000	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6I62_RS16005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I62_RS16015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I62_RS16025	COG0250	Participates in transcription elongation, termination and antitermination
I6I62_RS16040	COG2032	superoxide dismutase activity
I6I62_RS16045	COG0561	phosphatase activity
I6I62_RS16055	COG0584	glycerophosphoryl diester phosphodiesterase
I6I62_RS16060	COG1012	belongs to the aldehyde dehydrogenase family
I6I62_RS16060	COG1454	alcohol dehydrogenase
I6I62_RS16070	COG0504	CTP synthase activity
I6I62_RS16095	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6I62_RS16115	COG5001	Diguanylate cyclase
I6I62_RS16115	COG3300	MHYT domain
I6I62_RS16130	COG1671	Belongs to the UPF0178 family
I6I62_RS16140	COG0367	asparagine synthase
I6I62_RS16145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I62_RS16150	COG0561	phosphatase activity
I6I62_RS16160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I62_RS16165	COG0366	Alpha amylase catalytic
I6I62_RS16185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I62_RS16195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I62_RS16215	COG0582	viral genome integration into host DNA
I6I62_RS16225	COG1674	ftsk spoiiie
I6I62_RS16265	COG4708	membrane
I6I62_RS16270	COG2169	Transcriptional regulator
I6I62_RS16290	COG2706	6-phosphogluconolactonase activity
I6I62_RS16305	COG0436	Aminotransferase
I6I62_RS16325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6I62_RS16340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I62_RS16345	COG0573	inorganic phosphate transmembrane transporter activity
I6I62_RS16350	COG0581	inorganic phosphate transmembrane transporter activity
I6I62_RS16355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I62_RS16360	COG0704	Plays a role in the regulation of phosphate uptake
I6I62_RS16365	COG0745	RESPONSE REGULATOR receiver
I6I62_RS16380	COG1307	EDD domain protein, DegV family
I6I62_RS16385	COG5002	protein histidine kinase activity
I6I62_RS16400	COG0640	Transcriptional regulator
I6I62_RS16410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I62_RS16420	COG0785	Cytochrome C biogenesis protein
I6I62_RS16425	COG1733	regulation of RNA biosynthetic process
I6I62_RS16435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I62_RS16445	COG0460	homoserine dehydrogenase
I6I62_RS16450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I62_RS16455	COG0083	homoserine kinase activity
I6I62_RS16470	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I62_RS16490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I62_RS16495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I62_RS16525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS16540	COG1482	cell wall glycoprotein biosynthetic process
I6I62_RS16545	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS16550	COG3711	transcriptional antiterminator
I6I62_RS16550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I62_RS16565	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I62_RS16580	COG0386	Belongs to the glutathione peroxidase family
I6I62_RS16635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I62_RS16645	COG2190	(PTS) system
I6I62_RS16645	COG1263	PTS System
I6I62_RS16645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS16650	COG3711	transcriptional antiterminator
I6I62_RS16655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS16655	COG2190	(PTS) system
I6I62_RS16655	COG1263	PTS System
I6I62_RS16725	COG1192	Involved in chromosome partitioning
I6I62_RS16745	COG3328	transposase activity
I6I62_RS16795	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6I62_RS16800	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS16805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS16810	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS16815	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS16825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I62_RS16830	COG2723	6-phospho-beta-galactosidase activity
I6I62_RS16865	COG3250	beta-galactosidase activity
I6I62_RS16870	COG1704	LemA family
I6I62_RS16880	COG1486	melibiose metabolic process
I6I62_RS16895	COG1307	EDD domain protein, DegV family
I6I62_RS16935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I62_RS16965	COG1269	ATP hydrolysis coupled proton transport
I6I62_RS16995	COG1394	ATPase activity, coupled to movement of substances
I6I62_RS17010	COG1131	(ABC) transporter
I6I62_RS17020	COG1940	carbohydrate kinase activity
I6I62_RS17035	COG0367	asparagine synthase
I6I62_RS17040	COG1263	PTS System
I6I62_RS17040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I62_RS17050	COG1486	melibiose metabolic process
I6I62_RS17065	COG1737	Transcriptional regulator
I6I62_RS17090	COG2188	Transcriptional regulator