locus-tag	class	description
H9L01_RS00005	COG0583	DNA-binding transcription factor activity
H9L01_RS00015	COG0280	phosphate acetyltransferase
H9L01_RS00045	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9L01_RS00070	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9L01_RS00085	COG0277	FAD linked oxidase domain protein
H9L01_RS00095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9L01_RS00100	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H9L01_RS00140	COG1418	mRNA catabolic process
H9L01_RS00145	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9L01_RS00150	COG1394	ATPase activity, coupled to movement of substances
H9L01_RS00160	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
H9L01_RS00200	COG4608	Belongs to the ABC transporter superfamily
H9L01_RS00205	COG0444	Belongs to the ABC transporter superfamily
H9L01_RS00210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L01_RS00215	COG0601	transmembrane transport
H9L01_RS00220	COG4166	transmembrane transport
H9L01_RS00225	COG0205	6-phosphofructokinase activity
H9L01_RS00230	COG0488	(ABC) transporter
H9L01_RS00240	COG0017	Asparaginyl-tRNA synthetase
H9L01_RS00245	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H9L01_RS00250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9L01_RS00260	COG1214	PFAM Peptidase M22, glycoprotease
H9L01_RS00265	COG0802	atpase or kinase
H9L01_RS00270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9L01_RS00295	COG4120	Belongs to the binding-protein-dependent transport system permease family
H9L01_RS00315	COG0789	Transcriptional regulator
H9L01_RS00320	COG2233	PERMEase
H9L01_RS00330	COG1164	Oligoendopeptidase f
H9L01_RS00345	COG1649	PFAM Uncharacterised BCR, COG1649
H9L01_RS00350	COG1408	metallophosphoesterase
H9L01_RS00355	COG0745	RESPONSE REGULATOR receiver
H9L01_RS00365	COG2365	Tyrosine phosphatase family
H9L01_RS00375	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9L01_RS00380	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H9L01_RS00400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS00405	COG2723	6-phospho-beta-galactosidase activity
H9L01_RS00410	COG1737	Transcriptional regulator
H9L01_RS00435	COG2801	Transposase and inactivated derivatives
H9L01_RS00445	COG1131	(ABC) transporter
H9L01_RS00460	COG0561	phosphatase activity
H9L01_RS00465	COG1486	melibiose metabolic process
H9L01_RS00470	COG2706	6-phosphogluconolactonase activity
H9L01_RS00485	COG0693	protein deglycase activity
H9L01_RS00490	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H9L01_RS00525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS00530	COG1486	melibiose metabolic process
H9L01_RS00535	COG2207	Transcriptional regulator
H9L01_RS00540	COG1473	amidohydrolase
H9L01_RS00560	COG1063	alcohol dehydrogenase
H9L01_RS00565	COG0395	ABC-type sugar transport system, permease component
H9L01_RS00570	COG1175	transmembrane transport
H9L01_RS00620	COG1196	nuclear chromosome segregation
H9L01_RS00660	COG0569	domain protein
H9L01_RS00665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9L01_RS00680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9L01_RS00685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9L01_RS00690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L01_RS00700	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L01_RS00720	COG2183	response to ionizing radiation
H9L01_RS00730	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H9L01_RS00745	COG0668	transmembrane transport
H9L01_RS00760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L01_RS00765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L01_RS00770	COG1780	Probably involved in ribonucleotide reductase function
H9L01_RS00780	COG1164	Oligoendopeptidase f
H9L01_RS00830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L01_RS00835	COG0154	amidase activity
H9L01_RS00840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9L01_RS00850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9L01_RS00855	COG0210	DNA helicase
H9L01_RS00860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9L01_RS00860	COG0116	Belongs to the methyltransferase superfamily
H9L01_RS00865	COG0564	pseudouridine synthase activity
H9L01_RS00875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L01_RS00905	COG0564	pseudouridine synthase activity
H9L01_RS00920	COG0583	DNA-binding transcription factor activity
H9L01_RS00945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L01_RS00950	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H9L01_RS00955	COG2217	Heavy metal translocating P-type atpase
H9L01_RS00960	COG0640	Transcriptional regulator
H9L01_RS00965	COG0783	Belongs to the Dps family
H9L01_RS00970	COG1349	DNA-binding transcription factor activity
H9L01_RS00975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H9L01_RS00985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9L01_RS00990	COG1454	alcohol dehydrogenase
H9L01_RS01000	COG1288	antiporter activity
H9L01_RS01010	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9L01_RS01015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9L01_RS01020	COG1121	(ABC) transporter
H9L01_RS01035	COG2801	Transposase and inactivated derivatives
H9L01_RS01045	COG0728	peptidoglycan biosynthetic process
H9L01_RS01050	COG0728	peptidoglycan biosynthetic process
H9L01_RS01055	COG1187	pseudouridine synthase activity
H9L01_RS01060	COG1242	4 iron, 4 sulfur cluster binding
H9L01_RS01070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9L01_RS01105	COG0583	DNA-binding transcription factor activity
H9L01_RS01135	COG1482	cell wall glycoprotein biosynthetic process
H9L01_RS01140	COG1940	carbohydrate kinase activity
H9L01_RS01145	COG1940	carbohydrate kinase activity
H9L01_RS01150	COG2723	6-phospho-beta-galactosidase activity
H9L01_RS01155	COG0383	alpha-mannosidase activity
H9L01_RS01165	COG1609	Transcriptional regulator
H9L01_RS01175	COG4753	response regulator
H9L01_RS01175	COG2207	Transcriptional regulator
H9L01_RS01180	COG2972	Histidine kinase
H9L01_RS01190	COG1653	transport
H9L01_RS01195	COG0395	ABC-type sugar transport system, permease component
H9L01_RS01200	COG1175	transmembrane transport
H9L01_RS01220	COG1737	Transcriptional regulator
H9L01_RS01240	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L01_RS01250	COG3328	transposase activity
H9L01_RS01295	COG0280	phosphate acetyltransferase
H9L01_RS01305	COG1309	transcriptional regulator
H9L01_RS01310	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H9L01_RS01315	COG3118	belongs to the thioredoxin family
H9L01_RS01320	COG1959	2 iron, 2 sulfur cluster binding
H9L01_RS01330	COG3878	Protein conserved in bacteria
H9L01_RS01340	COG0424	maF-like protein
H9L01_RS01350	COG0745	RESPONSE REGULATOR receiver
H9L01_RS01360	COG1346	cytolysis
H9L01_RS01365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L01_RS01370	COG1408	metallophosphoesterase
H9L01_RS01435	COG0142	geranyltranstransferase activity
H9L01_RS01440	COG1252	NADH dehydrogenase
H9L01_RS01445	COG0495	leucyl-tRNA aminoacylation
H9L01_RS01455	COG2226	methyltransferase
H9L01_RS01490	COG0584	glycerophosphoryl diester phosphodiesterase
H9L01_RS01495	COG0564	pseudouridine synthase activity
H9L01_RS01500	COG0561	phosphatase activity
H9L01_RS01510	COG2217	Heavy metal translocating P-type atpase
H9L01_RS01525	COG0523	cobalamin synthesis protein
H9L01_RS01535	COG3328	transposase activity
H9L01_RS01545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9L01_RS01560	COG1278	Cold shock
H9L01_RS01565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9L01_RS01575	COG3620	sequence-specific DNA binding
H9L01_RS01590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L01_RS01625	COG0656	L-ascorbic acid biosynthetic process
H9L01_RS01640	COG0424	maF-like protein
H9L01_RS01650	COG2205	protein histidine kinase activity
H9L01_RS01650	COG2770	Histidine kinase
H9L01_RS01655	COG0745	RESPONSE REGULATOR receiver
H9L01_RS01660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L01_RS01670	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H9L01_RS01675	COG1132	(ABC) transporter
H9L01_RS01690	COG1704	LemA family
H9L01_RS01695	COG0326	Molecular chaperone. Has ATPase activity
H9L01_RS01715	COG1827	regulation of RNA biosynthetic process
H9L01_RS01725	COG1393	Belongs to the ArsC family
H9L01_RS01735	COG0081	regulation of translation
H9L01_RS01745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9L01_RS01755	COG2813	Specifically methylates the guanine in position
H9L01_RS01760	COG0222	ribosome binding
H9L01_RS01820	COG0765	amino acid transport
H9L01_RS01825	COG1126	abc transporter atp-binding protein
H9L01_RS01830	COG0285	dihydrofolate synthase activity
H9L01_RS01835	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9L01_RS01845	COG1304	FMN binding
H9L01_RS01860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9L01_RS01865	COG0250	Participates in transcription elongation, termination and antitermination
H9L01_RS01870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9L01_RS01875	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L01_RS01885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L01_RS01890	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H9L01_RS01895	COG0215	cysteine-tRNA ligase activity
H9L01_RS01915	COG1481	regulation of sporulation
H9L01_RS01920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H9L01_RS01925	COG1660	Displays ATPase and GTPase activities
H9L01_RS01930	COG0492	ferredoxin-NADP+ reductase activity
H9L01_RS01945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L01_RS01955	COG0556	nucleotide-excision repair
H9L01_RS01960	COG3409	Peptidoglycan-binding domain 1 protein
H9L01_RS01960	COG0793	Belongs to the peptidase S41A family
H9L01_RS01970	COG0739	heme binding
H9L01_RS01975	COG0739	heme binding
H9L01_RS01980	COG2177	Part of the ABC transporter FtsEX involved in
H9L01_RS01985	COG2884	Cell division ATP-binding protein ftsE
H9L01_RS01990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L01_RS01995	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H9L01_RS02005	COG1278	Cold shock
H9L01_RS02010	COG1040	competence protein
H9L01_RS02015	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H9L01_RS02045	COG2176	DNA-directed DNA polymerase activity
H9L01_RS02055	COG0569	domain protein
H9L01_RS02060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L01_RS02075	COG0557	exoribonuclease II activity
H9L01_RS02085	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H9L01_RS02090	COG3655	Transcriptional regulator
H9L01_RS02095	COG1328	CTP reductase activity
H9L01_RS02095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9L01_RS02140	COG0166	Belongs to the GPI family
H9L01_RS02150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H9L01_RS02160	COG1132	(ABC) transporter
H9L01_RS02170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9L01_RS02170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H9L01_RS02195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9L01_RS02200	COG0745	RESPONSE REGULATOR receiver
H9L01_RS02205	COG5002	protein histidine kinase activity
H9L01_RS02205	COG3850	Histidine kinase
H9L01_RS02210	COG0577	efflux transmembrane transporter activity
H9L01_RS02210	COG1136	(ABC) transporter
H9L01_RS02220	COG0577	efflux transmembrane transporter activity
H9L01_RS02220	COG1136	(ABC) transporter
H9L01_RS02230	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H9L01_RS02240	COG0343	queuine tRNA-ribosyltransferase activity
H9L01_RS02250	COG0024	Methionine aminopeptidase
H9L01_RS02270	COG1194	a g-specific adenine glycosylase
H9L01_RS02285	COG2252	PERMEase
H9L01_RS02300	COG0789	Transcriptional regulator
H9L01_RS02305	COG1131	(ABC) transporter
H9L01_RS02330	COG4808	Protein conserved in bacteria
H9L01_RS02340	COG1882	Formate acetyltransferase
H9L01_RS02345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS02350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9L01_RS02355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9L01_RS02360	COG0698	ribose 5-phosphate isomerase
H9L01_RS02365	COG0009	L-threonylcarbamoyladenylate synthase
H9L01_RS02380	COG1435	thymidine kinase activity
H9L01_RS02385	COG0254	rRNA binding
H9L01_RS02420	COG1131	(ABC) transporter
H9L01_RS02425	COG1131	(ABC) transporter
H9L01_RS02480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9L01_RS02495	COG2116	formate transmembrane transporter activity
H9L01_RS02505	COG0504	CTP synthase activity
H9L01_RS02520	COG0006	proline dipeptidase activity
H9L01_RS02525	COG1078	dGTPase activity
H9L01_RS02530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L01_RS02535	COG0183	Belongs to the thiolase family
H9L01_RS02540	COG3425	synthase
H9L01_RS02545	COG3870	Protein conserved in bacteria
H9L01_RS02550	COG0012	GTP binding
H9L01_RS02555	COG4481	Protein conserved in bacteria
H9L01_RS02560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9L01_RS02570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9L01_RS02590	COG0513	Belongs to the DEAD box helicase family
H9L01_RS02595	COG0708	Exodeoxyribonuclease III
H9L01_RS02605	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H9L01_RS02615	COG3069	C4-dicarboxylate transmembrane transporter activity
H9L01_RS02635	COG1609	Transcriptional regulator
H9L01_RS02645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9L01_RS02650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9L01_RS02660	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9L01_RS02685	COG1012	belongs to the aldehyde dehydrogenase family
H9L01_RS02695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9L01_RS02700	COG2011	ABC-type metal ion transport system permease component
H9L01_RS02715	COG0556	nucleotide-excision repair
H9L01_RS02720	COG0084	hydrolase, TatD family'
H9L01_RS02725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9L01_RS02730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9L01_RS02750	COG1475	DNA binding
H9L01_RS02755	COG1192	Involved in chromosome partitioning
H9L01_RS02765	COG0357	Ribosomal RNA small subunit methyltransferase G
H9L01_RS02770	COG0673	inositol 2-dehydrogenase activity
H9L01_RS02775	COG0745	RESPONSE REGULATOR receiver
H9L01_RS02795	COG1725	Transcriptional regulator
H9L01_RS02800	COG1131	(ABC) transporter
H9L01_RS02810	COG0588	phosphoglycerate mutase activity
H9L01_RS02835	COG0516	GMP reductase activity
H9L01_RS02845	COG0470	DNA polymerase III
H9L01_RS02850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9L01_RS02870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H9L01_RS02880	COG0193	aminoacyl-tRNA hydrolase activity
H9L01_RS02890	COG0706	membrane insertase activity
H9L01_RS02895	COG0594	ribonuclease P activity
H9L01_RS02910	COG0592	DNA-directed DNA polymerase activity
H9L01_RS02915	COG2501	S4 domain
H9L01_RS02920	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9L01_RS02925	COG0187	DNA topoisomerase II activity
H9L01_RS02930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9L01_RS02945	COG2226	methyltransferase
H9L01_RS02960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9L01_RS02965	COG0561	phosphatase activity
H9L01_RS02980	COG3764	Sortase (surface protein transpeptidase)
H9L01_RS02985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9L01_RS02990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9L01_RS03010	COG0772	Belongs to the SEDS family
H9L01_RS03025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9L01_RS03030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9L01_RS03035	COG1307	EDD domain protein, DegV family
H9L01_RS03040	COG1307	EDD domain protein, DegV family
H9L01_RS03045	COG1739	Uncharacterized protein family UPF0029
H9L01_RS03055	COG2514	catechol 2,3-dioxygenase activity
H9L01_RS03060	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H9L01_RS03085	COG0671	phosphoesterase, PA-phosphatase related
H9L01_RS03110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L01_RS03110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L01_RS03115	COG1132	(ABC) transporter
H9L01_RS03120	COG1132	(ABC) transporter
H9L01_RS03145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9L01_RS03160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS03170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9L01_RS03185	COG4946	Tricorn protease homolog
H9L01_RS03185	COG1506	peptidase
H9L01_RS03185	COG0823	Involved in the tonB-independent uptake of proteins
H9L01_RS03200	COG2357	RelA SpoT domain protein
H9L01_RS03205	COG4841	protein insertion into membrane
H9L01_RS03210	COG0517	IMP dehydrogenase activity
H9L01_RS03210	COG0516	GMP reductase activity
H9L01_RS03225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L01_RS03230	COG1217	gtp-binding protein TYPA
H9L01_RS03235	COG1322	Protein conserved in bacteria
H9L01_RS03245	COG0656	L-ascorbic acid biosynthetic process
H9L01_RS03250	COG2217	Heavy metal translocating P-type atpase
H9L01_RS03255	COG0800	Aldolase
H9L01_RS03260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS03275	COG0517	IMP dehydrogenase activity
H9L01_RS03275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H9L01_RS03280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L01_RS03285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS03290	COG0281	malic enzyme
H9L01_RS03295	COG0114	fumarate hydratase activity
H9L01_RS03310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS03315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS03325	COG1363	Peptidase, m42
H9L01_RS03330	COG1363	Peptidase, m42
H9L01_RS03335	COG1446	asparaginase
H9L01_RS03345	COG1027	Aspartate ammonia-lyase
H9L01_RS03350	COG3142	Participates in the control of copper homeostasis
H9L01_RS03375	COG0037	tRNA processing
H9L01_RS03380	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H9L01_RS03385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9L01_RS03390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9L01_RS03395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H9L01_RS03400	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9L01_RS03405	COG0360	Binds together with S18 to 16S ribosomal RNA
H9L01_RS03410	COG0629	single-stranded DNA binding
H9L01_RS03415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9L01_RS03425	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H9L01_RS03430	COG0359	binds to the 23S rRNA
H9L01_RS03435	COG0305	Participates in initiation and elongation during chromosome replication
H9L01_RS03440	COG1388	LysM domain
H9L01_RS03440	COG4942	peptidase
H9L01_RS03445	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H9L01_RS03450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L01_RS03455	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9L01_RS03460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS03465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L01_RS03490	COG4989	oxidoreductase activity
H9L01_RS03525	COG1285	pathogenesis
H9L01_RS03530	COG0483	inositol monophosphate 1-phosphatase activity
H9L01_RS03535	COG0483	inositol monophosphate 1-phosphatase activity
H9L01_RS03540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L01_RS03545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H9L01_RS03560	COG1011	Hydrolase
H9L01_RS03575	COG1309	transcriptional regulator
H9L01_RS03580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H9L01_RS03590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L01_RS03615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L01_RS03635	COG0513	Belongs to the DEAD box helicase family
H9L01_RS03640	COG4895	conserved protein (DUF2196)
H9L01_RS03645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L01_RS03655	COG0583	DNA-binding transcription factor activity
H9L01_RS03660	COG2391	methyltransferase activity
H9L01_RS03665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9L01_RS03665	COG0425	Belongs to the sulfur carrier protein TusA family
H9L01_RS03670	COG2391	methyltransferase activity
H9L01_RS03680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L01_RS03690	COG0431	NADPH-dependent FMN reductase
H9L01_RS03695	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H9L01_RS03700	COG0511	ligase activity, forming carbon-carbon bonds
H9L01_RS03705	COG0439	Biotin carboxylase
H9L01_RS03710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9L01_RS03715	COG0825	malonyl-CoA metabolic process
H9L01_RS03720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L01_RS03725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L01_RS03730	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H9L01_RS03740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L01_RS03750	COG0204	Acyl-transferase
H9L01_RS03770	COG0577	efflux transmembrane transporter activity
H9L01_RS03770	COG1136	(ABC) transporter
H9L01_RS03780	COG0076	glutamate decarboxylase activity
H9L01_RS03810	COG1131	(ABC) transporter
H9L01_RS03815	COG2205	protein histidine kinase activity
H9L01_RS03820	COG0745	RESPONSE REGULATOR receiver
H9L01_RS03840	COG1307	EDD domain protein, DegV family
H9L01_RS03845	COG1725	Transcriptional regulator
H9L01_RS03850	COG1131	(ABC) transporter
H9L01_RS03860	COG0622	Phosphoesterase
H9L01_RS03870	COG1316	TRANSCRIPTIONal
H9L01_RS03875	COG1597	lipid kinase activity
H9L01_RS03880	COG3118	belongs to the thioredoxin family
H9L01_RS03890	COG3842	ATPase activity
H9L01_RS03895	COG1176	ABC-type spermidine putrescine transport system, permease component I
H9L01_RS03900	COG1177	transmembrane transport
H9L01_RS03905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H9L01_RS04030	COG0726	polysaccharide deacetylase
H9L01_RS04045	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
H9L01_RS04060	COG1187	pseudouridine synthase activity
H9L01_RS04070	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L01_RS04075	COG1388	LysM domain
H9L01_RS04075	COG4932	domain protein
H9L01_RS04115	COG0346	lactoylglutathione lyase activity
H9L01_RS04120	COG0346	lactoylglutathione lyase activity
H9L01_RS04130	COG0400	carboxylic ester hydrolase activity
H9L01_RS04135	COG0431	NADPH-dependent FMN reductase
H9L01_RS04145	COG3711	transcriptional antiterminator
H9L01_RS04150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9L01_RS04180	COG2188	Transcriptional regulator
H9L01_RS04185	COG1028	Short-chain dehydrogenase reductase Sdr
H9L01_RS04190	COG2213	PTS system mannitol-specific
H9L01_RS04195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS04215	COG3340	Belongs to the peptidase S51 family
H9L01_RS04220	COG1045	serine acetyltransferase
H9L01_RS04230	COG3340	Belongs to the peptidase S51 family
H9L01_RS04250	COG2217	Heavy metal translocating P-type atpase
H9L01_RS04255	COG0640	Transcriptional regulator
H9L01_RS04295	COG4886	Leucine-rich repeat (LRR) protein
H9L01_RS04315	COG1695	Transcriptional regulator
H9L01_RS04340	COG0488	(ABC) transporter
H9L01_RS04355	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS04370	COG2188	Transcriptional regulator
H9L01_RS04375	COG1054	Belongs to the UPF0176 family
H9L01_RS04380	COG1694	Mazg nucleotide pyrophosphohydrolase
H9L01_RS04385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L01_RS04390	COG1288	antiporter activity
H9L01_RS04405	COG4978	Transcriptional regulator
H9L01_RS04405	COG0789	Transcriptional regulator
H9L01_RS04415	COG1132	(ABC) transporter
H9L01_RS04440	COG3711	transcriptional antiterminator
H9L01_RS04445	COG1263	PTS System
H9L01_RS04445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS04455	COG1309	transcriptional regulator
H9L01_RS04480	COG1309	transcriptional regulator
H9L01_RS04510	COG1283	sodium-dependent phosphate transmembrane transporter activity
H9L01_RS04550	COG1840	ABC-type Fe3 transport system, periplasmic component
H9L01_RS04555	COG3842	ATPase activity
H9L01_RS04570	COG2207	Transcriptional regulator
H9L01_RS04570	COG4753	response regulator
H9L01_RS04585	COG1737	Transcriptional regulator
H9L01_RS04590	COG1486	melibiose metabolic process
H9L01_RS04595	COG2190	(PTS) system
H9L01_RS04595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS04595	COG1263	PTS System
H9L01_RS04600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9L01_RS04605	COG2190	(PTS) system
H9L01_RS04615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9L01_RS04625	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H9L01_RS04635	COG0488	(ABC) transporter
H9L01_RS04640	COG1464	Belongs to the NlpA lipoprotein family
H9L01_RS04645	COG2011	ABC-type metal ion transport system permease component
H9L01_RS04650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9L01_RS04675	COG1012	belongs to the aldehyde dehydrogenase family
H9L01_RS04675	COG1454	alcohol dehydrogenase
H9L01_RS04680	COG4886	Leucine-rich repeat (LRR) protein
H9L01_RS04680	COG4932	domain protein
H9L01_RS04695	COG0813	purine-nucleoside phosphorylase activity
H9L01_RS04705	COG1131	(ABC) transporter
H9L01_RS04710	COG2910	NAD(P)H-binding
H9L01_RS04715	COG0454	-acetyltransferase
H9L01_RS04725	COG2217	Heavy metal translocating P-type atpase
H9L01_RS04730	COG1278	Cold shock
H9L01_RS04750	COG0126	phosphoglycerate kinase activity
H9L01_RS04755	COG0149	triose-phosphate isomerase activity
H9L01_RS04785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L01_RS04795	COG2207	Transcriptional regulator
H9L01_RS04810	COG1175	transmembrane transport
H9L01_RS04815	COG0395	ABC-type sugar transport system, permease component
H9L01_RS04820	COG5426	von Willebrand factor, type A
H9L01_RS04840	COG0366	Alpha amylase catalytic
H9L01_RS04855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS04860	COG1737	Transcriptional regulator
H9L01_RS04865	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H9L01_RS04870	COG0251	oxidation-reduction process
H9L01_RS04880	COG0443	Heat shock 70 kDa protein
H9L01_RS04890	COG0484	heat shock protein binding
H9L01_RS04900	COG0673	inositol 2-dehydrogenase activity
H9L01_RS04920	COG0492	ferredoxin-NADP+ reductase activity
H9L01_RS04930	COG0640	Transcriptional regulator
H9L01_RS04940	COG1733	regulation of RNA biosynthetic process
H9L01_RS04945	COG0300	oxidoreductase activity
H9L01_RS04955	COG0517	IMP dehydrogenase activity
H9L01_RS04955	COG0516	GMP reductase activity
H9L01_RS04960	COG0519	Catalyzes the synthesis of GMP from XMP
H9L01_RS04985	COG1131	(ABC) transporter
H9L01_RS05010	COG0488	(ABC) transporter
H9L01_RS05020	COG1309	transcriptional regulator
H9L01_RS05045	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H9L01_RS05050	COG0390	transport system, permease component
H9L01_RS05055	COG4619	ABC transporter
H9L01_RS05060	COG0662	Cupin 2, conserved barrel domain protein
H9L01_RS05070	COG3711	transcriptional antiterminator
H9L01_RS05075	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS05080	COG1105	Belongs to the carbohydrate kinase PfkB family
H9L01_RS05085	COG1063	alcohol dehydrogenase
H9L01_RS05090	COG0513	Belongs to the DEAD box helicase family
H9L01_RS05140	COG1196	nuclear chromosome segregation
H9L01_RS05140	COG0741	lytic transglycosylase activity
H9L01_RS05140	COG0739	heme binding
H9L01_RS05150	COG0519	Catalyzes the synthesis of GMP from XMP
H9L01_RS05150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9L01_RS05180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9L01_RS05205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS05205	COG1263	PTS System
H9L01_RS05210	COG3180	Ammonia monooxygenase
H9L01_RS05220	COG1737	Transcriptional regulator
H9L01_RS05230	COG0758	DNA mediated transformation
H9L01_RS05235	COG4886	Leucine-rich repeat (LRR) protein
H9L01_RS05240	COG0519	Catalyzes the synthesis of GMP from XMP
H9L01_RS05255	COG0561	phosphatase activity
H9L01_RS05265	COG3314	Sporulation integral membrane protein YlbJ
H9L01_RS05275	COG1414	Transcriptional regulator
H9L01_RS05280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L01_RS05285	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H9L01_RS05290	COG1132	(ABC) transporter
H9L01_RS05315	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H9L01_RS05350	COG3933	PFAM sigma-54 factor interaction domain-containing protein
H9L01_RS05350	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
H9L01_RS05360	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS05360	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS05365	COG3715	PTS system
H9L01_RS05370	COG3716	PTS system mannose fructose sorbose family IID component
H9L01_RS05375	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H9L01_RS05385	COG2272	Belongs to the type-B carboxylesterase lipase family
H9L01_RS05440	COG1263	PTS System
H9L01_RS05440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS05445	COG3394	polysaccharide catabolic process
H9L01_RS05450	COG1486	melibiose metabolic process
H9L01_RS05455	COG1737	Transcriptional regulator
H9L01_RS05475	COG0577	efflux transmembrane transporter activity
H9L01_RS05475	COG1136	(ABC) transporter
H9L01_RS05490	COG1454	alcohol dehydrogenase
H9L01_RS05495	COG0561	phosphatase activity
H9L01_RS05510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS05510	COG3711	transcriptional antiterminator
H9L01_RS05520	COG1263	PTS System
H9L01_RS05520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS05530	COG2190	(PTS) system
H9L01_RS05535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9L01_RS05545	COG0456	acetyltransferase
H9L01_RS05545	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
H9L01_RS05560	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L01_RS05565	COG0425	Belongs to the sulfur carrier protein TusA family
H9L01_RS05565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9L01_RS05575	COG1414	Transcriptional regulator
H9L01_RS05585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9L01_RS05595	COG3715	PTS system
H9L01_RS05610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS05610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS05620	COG2365	Tyrosine phosphatase family
H9L01_RS05630	COG0366	Alpha amylase catalytic
H9L01_RS05640	COG2608	mercury ion transmembrane transporter activity
H9L01_RS05645	COG2217	Heavy metal translocating P-type atpase
H9L01_RS05655	COG4978	Transcriptional regulator
H9L01_RS05655	COG0789	Transcriptional regulator
H9L01_RS05680	COG1136	(ABC) transporter
H9L01_RS05680	COG0577	efflux transmembrane transporter activity
H9L01_RS05695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H9L01_RS05705	COG0450	alkyl hydroperoxide reductase
H9L01_RS05710	COG3634	alkyl hydroperoxide reductase activity
H9L01_RS05715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9L01_RS05720	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9L01_RS05735	COG1823	symporter activity
H9L01_RS05740	COG2081	HI0933 family
H9L01_RS05755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L01_RS05765	COG1309	transcriptional regulator
H9L01_RS05770	COG2824	Alkylphosphonate utilization operon protein PhnA
H9L01_RS05775	COG0363	glucosamine-6-phosphate deaminase activity
H9L01_RS05780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9L01_RS05785	COG1164	Oligoendopeptidase f
H9L01_RS05790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L01_RS05795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9L01_RS05815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9L01_RS05825	COG0745	RESPONSE REGULATOR receiver
H9L01_RS05830	COG0642	Histidine kinase
H9L01_RS05835	COG0577	efflux transmembrane transporter activity
H9L01_RS05845	COG1136	(ABC) transporter
H9L01_RS05890	COG0628	permease
H9L01_RS05895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9L01_RS05900	COG0049	tRNA binding
H9L01_RS05905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9L01_RS05910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9L01_RS05920	COG3842	ATPase activity
H9L01_RS05925	COG1178	ABC-type Fe3 transport system permease component
H9L01_RS05930	COG1213	nucleotidyl transferase
H9L01_RS05935	COG0051	transcription antitermination factor activity, RNA binding
H9L01_RS05940	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9L01_RS05945	COG0088	Forms part of the polypeptide exit tunnel
H9L01_RS05950	COG0089	rRNA binding
H9L01_RS05955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9L01_RS05960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9L01_RS05965	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9L01_RS05970	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9L01_RS05975	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9L01_RS05980	COG0255	Belongs to the universal ribosomal protein uL29 family
H9L01_RS05985	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9L01_RS06000	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9L01_RS06020	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9L01_RS06025	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9L01_RS06035	COG0201	protein transport
H9L01_RS06040	COG0563	adenylate kinase activity
H9L01_RS06045	COG0024	Methionine aminopeptidase
H9L01_RS06050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H9L01_RS06055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9L01_RS06060	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H9L01_RS06070	COG0202	RNA polymerase activity
H9L01_RS06075	COG0203	ribosomal protein L17
H9L01_RS06080	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS06095	COG2971	BadF BadG BcrA BcrD
H9L01_RS06110	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9L01_RS06115	COG1122	ATPase activity
H9L01_RS06125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H9L01_RS06130	COG0101	tRNA pseudouridine synthase activity
H9L01_RS06135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9L01_RS06195	COG1732	Glycine betaine
H9L01_RS06210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H9L01_RS06215	COG3842	ATPase activity
H9L01_RS06250	COG2851	Citrate transporter
H9L01_RS06270	COG0511	ligase activity, forming carbon-carbon bonds
H9L01_RS06280	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
H9L01_RS06285	COG3052	prosthetic group binding
H9L01_RS06295	COG3051	citrate lyase alpha subunit
H9L01_RS06300	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
H9L01_RS06300	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
H9L01_RS06310	COG5002	protein histidine kinase activity
H9L01_RS06315	COG0745	RESPONSE REGULATOR receiver
H9L01_RS06330	COG0519	Catalyzes the synthesis of GMP from XMP
H9L01_RS06335	COG0704	Plays a role in the regulation of phosphate uptake
H9L01_RS06365	COG2314	TM2 domain
H9L01_RS06370	COG1447	Phosphotransferase system cellobiose-specific component IIA
H9L01_RS06380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS06390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H9L01_RS06405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9L01_RS06410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H9L01_RS06425	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9L01_RS06430	COG0564	pseudouridine synthase activity
H9L01_RS06445	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L01_RS06455	COG1193	negative regulation of DNA recombination
H9L01_RS06460	COG0322	excinuclease ABC activity
H9L01_RS06465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9L01_RS06485	COG3964	amidohydrolase
H9L01_RS06500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L01_RS06515	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9L01_RS06525	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9L01_RS06530	COG1609	Transcriptional regulator
H9L01_RS06535	COG1879	ABC-type sugar transport system periplasmic component
H9L01_RS06540	COG1129	ABC transporter
H9L01_RS06545	COG4211	Belongs to the binding-protein-dependent transport system permease family
H9L01_RS06560	COG0110	maltose O-acetyltransferase activity
H9L01_RS06575	COG0017	Asparaginyl-tRNA synthetase
H9L01_RS06580	COG0017	Asparaginyl-tRNA synthetase
H9L01_RS06595	COG0525	valine-tRNA ligase activity
H9L01_RS06615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L01_RS06625	COG0686	Belongs to the AlaDH PNT family
H9L01_RS06635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H9L01_RS06640	COG1799	cell septum assembly
H9L01_RS06650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9L01_RS06655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L01_RS06665	COG2801	Transposase and inactivated derivatives
H9L01_RS06680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H9L01_RS06685	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
H9L01_RS06690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H9L01_RS06700	COG3859	Proton-coupled thiamine transporter YuaJ
H9L01_RS06705	COG3557	Belongs to the UPF0374 family
H9L01_RS06725	COG3842	ATPase activity
H9L01_RS06735	COG0395	ABC-type sugar transport system, permease component
H9L01_RS06770	COG0584	glycerophosphoryl diester phosphodiesterase
H9L01_RS06790	COG1428	Deoxynucleoside kinase
H9L01_RS06815	COG0737	Belongs to the 5'-nucleotidase family
H9L01_RS06830	COG1132	(ABC) transporter
H9L01_RS06835	COG1132	(ABC) transporter
H9L01_RS06840	COG1363	Peptidase, m42
H9L01_RS06845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS06860	COG2188	Transcriptional regulator
H9L01_RS06870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L01_RS06895	COG1695	Transcriptional regulator
H9L01_RS06905	COG3655	Transcriptional regulator
H9L01_RS06915	COG1028	Short-chain dehydrogenase reductase Sdr
H9L01_RS06925	COG0583	DNA-binding transcription factor activity
H9L01_RS06945	COG0095	Lipoate-protein ligase
H9L01_RS06970	COG4166	transmembrane transport
H9L01_RS06975	COG0601	transmembrane transport
H9L01_RS06980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9L01_RS06985	COG4608	Belongs to the ABC transporter superfamily
H9L01_RS06990	COG0444	Belongs to the ABC transporter superfamily
H9L01_RS07015	COG1132	(ABC) transporter
H9L01_RS07020	COG1132	(ABC) transporter
H9L01_RS07030	COG0596	Alpha beta hydrolase
H9L01_RS07035	COG0546	phosphoglycolate phosphatase activity
H9L01_RS07050	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9L01_RS07055	COG4605	iron ion homeostasis
H9L01_RS07060	COG4604	ABC transporter, ATP-binding protein
H9L01_RS07065	COG4607	ABC-type enterochelin transport system periplasmic component
H9L01_RS07085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9L01_RS07095	COG0588	phosphoglycerate mutase activity
H9L01_RS07105	COG1309	transcriptional regulator
H9L01_RS07125	COG0352	thiamine-phosphate diphosphorylase activity
H9L01_RS07130	COG3711	transcriptional antiterminator
H9L01_RS07130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS07135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS07140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L01_RS07145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L01_RS07145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L01_RS07145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9L01_RS07155	COG2723	6-phospho-beta-galactosidase activity
H9L01_RS07160	COG1918	ferrous iron import across plasma membrane
H9L01_RS07160	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H9L01_RS07165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H9L01_RS07170	COG1132	(ABC) transporter
H9L01_RS07190	COG1473	amidohydrolase
H9L01_RS07200	COG0765	amino acid transport
H9L01_RS07205	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9L01_RS07210	COG4716	Myosin-crossreactive antigen
H9L01_RS07240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L01_RS07245	COG2364	Membrane
H9L01_RS07250	COG1136	(ABC) transporter
H9L01_RS07250	COG0577	efflux transmembrane transporter activity
H9L01_RS07255	COG0745	RESPONSE REGULATOR receiver
H9L01_RS07260	COG5002	protein histidine kinase activity
H9L01_RS07260	COG3850	Histidine kinase
H9L01_RS07270	COG1131	(ABC) transporter
H9L01_RS07290	COG4753	response regulator
H9L01_RS07290	COG2207	Transcriptional regulator
H9L01_RS07295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L01_RS07315	COG0488	(ABC) transporter
H9L01_RS07320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9L01_RS07335	COG0519	Catalyzes the synthesis of GMP from XMP
H9L01_RS07340	COG1940	carbohydrate kinase activity
H9L01_RS07345	COG2205	protein histidine kinase activity
H9L01_RS07350	COG0745	RESPONSE REGULATOR receiver
H9L01_RS07360	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H9L01_RS07365	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H9L01_RS07370	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H9L01_RS07410	COG0124	histidyl-tRNA synthetase
H9L01_RS07415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9L01_RS07430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9L01_RS07435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9L01_RS07440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9L01_RS07450	COG2801	Transposase and inactivated derivatives
H9L01_RS07465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9L01_RS07475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9L01_RS07490	COG0251	oxidation-reduction process
H9L01_RS07500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9L01_RS07510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9L01_RS07515	COG1323	Belongs to the UPF0348 family
H9L01_RS07520	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9L01_RS07525	COG1363	Peptidase, m42
H9L01_RS07540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L01_RS07555	COG1609	Transcriptional regulator
H9L01_RS07560	COG0494	nUDIX hydrolase
H9L01_RS07565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H9L01_RS07570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS07570	COG1263	PTS System
H9L01_RS07580	COG2190	(PTS) system
H9L01_RS07580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS07580	COG1263	PTS System
H9L01_RS07585	COG3711	transcriptional antiterminator
H9L01_RS07600	COG1269	ATP hydrolysis coupled proton transport
H9L01_RS07605	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9L01_RS07660	COG4721	ABC-type cobalt transport system, permease component
H9L01_RS07665	COG1122	ATPase activity
H9L01_RS07690	COG0018	arginyl-trna synthetase
H9L01_RS07705	COG1760	l-serine dehydratase
H9L01_RS07710	COG1760	l-serine dehydratase
H9L01_RS07715	COG3842	ATPase activity
H9L01_RS07730	COG2801	Transposase and inactivated derivatives
H9L01_RS07735	COG1876	peptidase activity
H9L01_RS07740	COG2188	Transcriptional regulator
H9L01_RS07745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9L01_RS07755	COG1546	Belongs to the CinA family
H9L01_RS07755	COG1058	Belongs to the CinA family
H9L01_RS07760	COG0488	(ABC) transporter
H9L01_RS07770	COG1316	TRANSCRIPTIONal
H9L01_RS07780	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H9L01_RS07795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS07805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS07810	COG1737	Transcriptional regulator
H9L01_RS07820	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H9L01_RS07830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H9L01_RS07835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L01_RS07845	COG4750	Nucleotidyl transferase
H9L01_RS07850	COG0697	spore germination
H9L01_RS07860	COG1086	Polysaccharide biosynthesis protein
H9L01_RS07875	COG0728	peptidoglycan biosynthetic process
H9L01_RS07880	COG0438	transferase activity, transferring glycosyl groups
H9L01_RS07885	COG0438	transferase activity, transferring glycosyl groups
H9L01_RS07890	COG0438	transferase activity, transferring glycosyl groups
H9L01_RS07910	COG3475	LICD family
H9L01_RS07920	COG0438	transferase activity, transferring glycosyl groups
H9L01_RS07925	COG3475	LICD family
H9L01_RS07930	COG0706	membrane insertase activity
H9L01_RS07945	COG1388	LysM domain
H9L01_RS07945	COG4942	peptidase
H9L01_RS07960	COG2848	UPF0210 protein
H9L01_RS08010	COG0419	ATPase involved in DNA repair
H9L01_RS08020	COG0420	3'-5' exonuclease activity
H9L01_RS08025	COG0110	maltose O-acetyltransferase activity
H9L01_RS08060	COG0019	diaminopimelate decarboxylase activity
H9L01_RS08070	COG5002	protein histidine kinase activity
H9L01_RS08070	COG0642	Histidine kinase
H9L01_RS08075	COG0745	RESPONSE REGULATOR receiver
H9L01_RS08085	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
H9L01_RS08095	COG0151	Belongs to the GarS family
H9L01_RS08100	COG0138	bifunctional purine biosynthesis protein purh
H9L01_RS08105	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9L01_RS08110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9L01_RS08120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9L01_RS08130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L01_RS08145	COG0497	DNA recombination
H9L01_RS08150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9L01_RS08160	COG1722	exodeoxyribonuclease VII activity
H9L01_RS08165	COG1570	exodeoxyribonuclease VII activity
H9L01_RS08170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L01_RS08180	COG0346	lactoylglutathione lyase activity
H9L01_RS08195	COG0196	riboflavin kinase activity
H9L01_RS08200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9L01_RS08205	COG0765	amino acid transport
H9L01_RS08215	COG2801	Transposase and inactivated derivatives
H9L01_RS08230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9L01_RS08235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9L01_RS08245	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H9L01_RS08250	COG0195	Participates in both transcription termination and antitermination
H9L01_RS08265	COG4684	Psort location CytoplasmicMembrane, score
H9L01_RS08290	COG2153	protein acetylation
H9L01_RS08300	COG1396	sequence-specific DNA binding
H9L01_RS08305	COG2176	DNA-directed DNA polymerase activity
H9L01_RS08315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H9L01_RS08325	COG1302	Protein conserved in bacteria
H9L01_RS08330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9L01_RS08345	COG0632	four-way junction helicase activity
H9L01_RS08350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9L01_RS08360	COG2868	ribosomal protein
H9L01_RS08365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H9L01_RS08370	COG0726	polysaccharide deacetylase
H9L01_RS08375	COG1668	transmembrane transport
H9L01_RS08380	COG4152	abc transporter atp-binding protein
H9L01_RS08385	COG5002	protein histidine kinase activity
H9L01_RS08390	COG0745	RESPONSE REGULATOR receiver
H9L01_RS08395	COG0587	DNA-directed DNA polymerase activity
H9L01_RS08400	COG1131	(ABC) transporter
H9L01_RS08420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H9L01_RS08430	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H9L01_RS08435	COG0552	protein localization to endoplasmic reticulum
H9L01_RS08455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9L01_RS08465	COG0799	negative regulation of ribosome biogenesis
H9L01_RS08470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H9L01_RS08480	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9L01_RS08485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9L01_RS08490	COG0187	DNA topoisomerase II activity
H9L01_RS08495	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9L01_RS08500	COG4555	ABC transporter
H9L01_RS08510	COG2267	carboxylic ester hydrolase activity
H9L01_RS08515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H9L01_RS08525	COG0072	phenylalanine-tRNA ligase activity
H9L01_RS08525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9L01_RS08530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9L01_RS08540	COG0346	lactoylglutathione lyase activity
H9L01_RS08550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9L01_RS08555	COG1121	(ABC) transporter
H9L01_RS08560	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9L01_RS08570	COG2738	Putative neutral zinc metallopeptidase
H9L01_RS08575	COG0776	regulation of translation
H9L01_RS08580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9L01_RS08590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9L01_RS08600	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H9L01_RS08625	COG4537	Required for transformation and DNA binding
H9L01_RS08635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9L01_RS08645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L01_RS08650	COG0768	penicillin binding
H9L01_RS08655	COG0513	Belongs to the DEAD box helicase family
H9L01_RS08665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L01_RS08670	COG0305	Participates in initiation and elongation during chromosome replication
H9L01_RS08670	COG0358	DNA primase activity
H9L01_RS08680	COG1381	Involved in DNA repair and RecF pathway recombination
H9L01_RS08705	COG0704	Plays a role in the regulation of phosphate uptake
H9L01_RS08710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9L01_RS08715	COG0581	inorganic phosphate transmembrane transporter activity
H9L01_RS08720	COG0573	inorganic phosphate transmembrane transporter activity
H9L01_RS08730	COG5002	protein histidine kinase activity
H9L01_RS08735	COG0745	RESPONSE REGULATOR receiver
H9L01_RS08740	COG1702	phosphate starvation-inducible protein PhoH
H9L01_RS08745	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H9L01_RS08765	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9L01_RS08775	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9L01_RS08780	COG1187	pseudouridine synthase activity
H9L01_RS08785	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H9L01_RS08790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H9L01_RS08815	COG0612	Peptidase, M16
H9L01_RS08820	COG0612	Peptidase, M16
H9L01_RS08825	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9L01_RS08835	COG1079	Belongs to the binding-protein-dependent transport system permease family
H9L01_RS08840	COG4603	Belongs to the binding-protein-dependent transport system permease family
H9L01_RS08845	COG3845	ABC transporter
H9L01_RS08850	COG1744	ABC transporter substrate-binding protein PnrA-like
H9L01_RS08855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H9L01_RS08875	COG1940	carbohydrate kinase activity
H9L01_RS08880	COG0469	pyruvate kinase activity
H9L01_RS08885	COG0205	6-phosphofructokinase activity
H9L01_RS08890	COG1484	DNA-dependent DNA replication
H9L01_RS08900	COG0237	dephospho-CoA kinase activity
H9L01_RS08910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L01_RS08910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L01_RS08920	COG0628	permease
H9L01_RS08930	COG1792	Involved in formation and maintenance of cell shape
H9L01_RS08935	COG2003	Belongs to the UPF0758 family
H9L01_RS08940	COG1464	Belongs to the NlpA lipoprotein family
H9L01_RS08950	COG1902	pentaerythritol trinitrate reductase activity
H9L01_RS08965	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9L01_RS08975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9L01_RS08980	COG1162	GTPase activity
H9L01_RS08985	COG2815	serine threonine protein kinase
H9L01_RS08985	COG0515	serine threonine protein kinase
H9L01_RS08990	COG0631	protein serine/threonine phosphatase activity
H9L01_RS08995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L01_RS08995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9L01_RS09000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9L01_RS09005	COG0194	GDP metabolic process
H9L01_RS09045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS09050	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H9L01_RS09070	COG0542	response to heat
H9L01_RS09085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9L01_RS09090	COG1420	regulation of RNA biosynthetic process
H9L01_RS09115	COG0405	Gamma-glutamyltransferase
H9L01_RS09120	COG3196	Protein conserved in bacteria
H9L01_RS09125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9L01_RS09125	COG0574	Belongs to the PEP-utilizing enzyme family
H9L01_RS09130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H9L01_RS09135	COG3475	LICD family
H9L01_RS09140	COG0742	ribosomal rna small subunit methyltransferase
H9L01_RS09145	COG0772	Belongs to the SEDS family
H9L01_RS09150	COG0242	peptide deformylase activity
H9L01_RS09155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H9L01_RS09180	COG0431	NADPH-dependent FMN reductase
H9L01_RS09190	COG1733	regulation of RNA biosynthetic process
H9L01_RS09200	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
H9L01_RS09215	COG1136	(ABC) transporter
H9L01_RS09240	COG3271	cysteine-type peptidase activity
H9L01_RS09240	COG2274	protein secretion by the type I secretion system
H9L01_RS09260	COG1956	GAF domain-containing protein
H9L01_RS09265	COG0095	Lipoate-protein ligase
H9L01_RS09270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L01_RS09280	COG1525	nuclease
H9L01_RS09285	COG1114	Component of the transport system for branched-chain amino acids
H9L01_RS09300	COG2801	Transposase and inactivated derivatives
H9L01_RS09305	COG2267	carboxylic ester hydrolase activity
H9L01_RS09315	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H9L01_RS09320	COG1461	Dihydroxyacetone kinase
H9L01_RS09325	COG2376	Dihydroxyacetone kinase
H9L01_RS09330	COG1136	(ABC) transporter
H9L01_RS09330	COG0577	efflux transmembrane transporter activity
H9L01_RS09355	COG2376	Dihydroxyacetone kinase
H9L01_RS09360	COG0431	NADPH-dependent FMN reductase
H9L01_RS09365	COG2304	oxidoreductase activity
H9L01_RS09385	COG4716	Myosin-crossreactive antigen
H9L01_RS09405	COG0295	cytidine deaminase activity
H9L01_RS09410	COG1573	uracil-dna glycosylase
H9L01_RS09415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H9L01_RS09430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9L01_RS09435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L01_RS09445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9L01_RS09445	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H9L01_RS09460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9L01_RS09465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L01_RS09470	COG0768	penicillin binding
H9L01_RS09480	COG0275	rRNA processing
H9L01_RS09485	COG2001	Belongs to the MraZ family
H9L01_RS09490	COG0728	peptidoglycan biosynthetic process
H9L01_RS09505	COG1316	TRANSCRIPTIONal
H9L01_RS09510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9L01_RS09520	COG2801	Transposase and inactivated derivatives
H9L01_RS09535	COG4974	Belongs to the 'phage' integrase family
H9L01_RS09540	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H9L01_RS09545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9L01_RS09550	COG0758	DNA mediated transformation
H9L01_RS09555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L01_RS09565	COG0681	Belongs to the peptidase S26 family
H9L01_RS09570	COG0335	large ribosomal subunit rRNA binding
H9L01_RS09575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9L01_RS09580	COG0301	tRNA thio-modification
H9L01_RS09585	COG1104	cysteine desulfurase activity
H9L01_RS09595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9L01_RS09610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9L01_RS09625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9L01_RS09665	COG0822	iron-sulfur transferase activity
H9L01_RS09670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9L01_RS09675	COG0719	Fe-S assembly protein
H9L01_RS09695	COG0537	adenosine 5'-monophosphoramidase activity
H9L01_RS09700	COG1185	polyribonucleotide nucleotidyltransferase activity
H9L01_RS09725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H9L01_RS09735	COG2084	Dehydrogenase
H9L01_RS09740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9L01_RS09750	COG0481	GTPase activity
H9L01_RS09765	COG0268	Binds directly to 16S ribosomal RNA
H9L01_RS09775	COG2333	competence protein COMEC
H9L01_RS09775	COG0658	competence protein
H9L01_RS09780	COG1555	photosystem II stabilization
H9L01_RS09780	COG1596	polysaccharide export
H9L01_RS09790	COG0572	uridine kinase
H9L01_RS09795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9L01_RS09800	COG3906	Belongs to the UPF0473 family
H9L01_RS09805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9L01_RS09810	COG4472	Bacterial protein of unknown function (DUF965)
H9L01_RS09835	COG1253	flavin adenine dinucleotide binding
H9L01_RS09845	COG1136	(ABC) transporter
H9L01_RS09850	COG0617	tRNA 3'-terminal CCA addition
H9L01_RS09855	COG1396	sequence-specific DNA binding
H9L01_RS09865	COG1609	Transcriptional regulator
H9L01_RS09880	COG3639	organic phosphonate transmembrane transporter activity
H9L01_RS09885	COG3639	organic phosphonate transmembrane transporter activity
H9L01_RS09915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9L01_RS09920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS09925	COG1486	melibiose metabolic process
H9L01_RS09930	COG1940	carbohydrate kinase activity
H9L01_RS09940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L01_RS09990	COG0288	reversible hydration of carbon dioxide
H9L01_RS10000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS10000	COG2190	(PTS) system
H9L01_RS10000	COG1263	PTS System
H9L01_RS10005	COG0366	Alpha amylase catalytic
H9L01_RS10015	COG3711	transcriptional antiterminator
H9L01_RS10020	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9L01_RS10040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9L01_RS10060	COG0180	Tryptophanyl-tRNA synthetase
H9L01_RS10065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L01_RS10070	COG3763	UPF0154 protein
H9L01_RS10080	COG0442	prolyl-tRNA aminoacylation
H9L01_RS10085	COG0737	Belongs to the 5'-nucleotidase family
H9L01_RS10095	COG1307	EDD domain protein, DegV family
H9L01_RS10100	COG1674	ftsk spoiiie
H9L01_RS10100	COG4980	gas vesicle protein
H9L01_RS10105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H9L01_RS10135	COG1692	metallophosphoesterase
H9L01_RS10140	COG1418	mRNA catabolic process
H9L01_RS10145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9L01_RS10150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9L01_RS10165	COG3599	regulation of cell shape
H9L01_RS10170	COG3331	DNA recombination
H9L01_RS10180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L01_RS10185	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L01_RS10190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L01_RS10195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9L01_RS10210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS10235	COG5263	repeat protein
H9L01_RS10235	COG4193	domain, Protein
H9L01_RS10240	COG1272	protein, Hemolysin III
H9L01_RS10245	COG0322	excinuclease ABC activity
H9L01_RS10260	COG0575	Belongs to the CDS family
H9L01_RS10270	COG0233	cytoplasmic translational termination
H9L01_RS10275	COG0528	UMP kinase activity
H9L01_RS10280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9L01_RS10295	COG0436	Aminotransferase
H9L01_RS10305	COG1686	Belongs to the peptidase S11 family
H9L01_RS10320	COG0336	Belongs to the RNA methyltransferase TrmD family
H9L01_RS10325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9L01_RS10340	COG3481	metal-dependent phosphohydrolase, HD sub domain
H9L01_RS10345	COG0438	transferase activity, transferring glycosyl groups
H9L01_RS10350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H9L01_RS10390	COG2801	Transposase and inactivated derivatives
H9L01_RS10440	COG1486	melibiose metabolic process
H9L01_RS10450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9L01_RS10450	COG1263	PTS System
H9L01_RS10455	COG1737	Transcriptional regulator
H9L01_RS10460	COG1737	Transcriptional regulator
H9L01_RS10480	COG0590	tRNA wobble adenosine to inosine editing
H9L01_RS10485	COG3469	chitinase activity
H9L01_RS10485	COG3325	Belongs to the glycosyl hydrolase 18 family
H9L01_RS10490	COG0167	dihydroorotate dehydrogenase activity
H9L01_RS10495	COG0543	2 iron, 2 sulfur cluster binding
H9L01_RS10500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9L01_RS10505	COG0505	Belongs to the CarA family
H9L01_RS10510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L01_RS10515	COG0540	Belongs to the ATCase OTCase family
H9L01_RS10520	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H9L01_RS10525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9L01_RS10555	COG1640	4-alpha-glucanotransferase
H9L01_RS10560	COG0058	SHG alpha-glucan phosphorylase activity
H9L01_RS10565	COG1609	Transcriptional regulator
H9L01_RS10575	COG3833	ABC-type maltose transport systems, permease component
H9L01_RS10580	COG1175	transmembrane transport
H9L01_RS10590	COG1523	belongs to the glycosyl hydrolase 13 family
H9L01_RS10605	COG0297	glycogen (starch) synthase activity
H9L01_RS10610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H9L01_RS10620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans