locus-tag	class	description
CP97_RS00025	COG2267	carboxylic ester hydrolase activity
CP97_RS00040	COG0582	viral genome integration into host DNA
CP97_RS00045	COG2801	Transposase and inactivated derivatives
CP97_RS00055	COG0789	Transcriptional regulator
CP97_RS00070	COG4771	TonB-dependent receptor
CP97_RS00075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP97_RS00125	COG0069	glutamate synthase activity
CP97_RS00130	COG0671	phosphoesterase, PA-phosphatase related
CP97_RS00135	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS00140	COG2351	hydroxyisourate hydrolase activity
CP97_RS00150	COG0668	transmembrane transport
CP97_RS00170	COG1285	pathogenesis
CP97_RS00200	COG4191	Histidine kinase
CP97_RS00205	COG4566	intracellular signal transduction
CP97_RS00220	COG2860	membrane
CP97_RS00225	COG0583	DNA-binding transcription factor activity
CP97_RS00230	COG1741	Belongs to the pirin family
CP97_RS00235	COG0431	NADPH-dependent FMN reductase
CP97_RS00240	COG2353	YceI-like domain
CP97_RS00245	COG3384	dioxygenase
CP97_RS00260	COG2801	Transposase and inactivated derivatives
CP97_RS00500	COG2801	Transposase and inactivated derivatives
CP97_RS00520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CP97_RS00540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP97_RS00600	COG0629	single-stranded DNA binding
CP97_RS00620	COG4227	nucleotidyltransferase activity
CP97_RS00680	COG1475	DNA binding
CP97_RS00690	COG4974	Belongs to the 'phage' integrase family
CP97_RS00695	COG4974	Belongs to the 'phage' integrase family
CP97_RS00700	COG4974	Belongs to the 'phage' integrase family
CP97_RS00715	COG0741	lytic transglycosylase activity
CP97_RS00745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP97_RS00750	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_RS00775	COG2070	2-Nitropropane dioxygenase
CP97_RS00780	COG0527	aspartate kinase activity
CP97_RS00785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP97_RS00790	COG2801	Transposase and inactivated derivatives
CP97_RS00800	COG1393	Belongs to the ArsC family
CP97_RS00825	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CP97_RS00835	COG0217	transcriptional regulatory protein
CP97_RS00840	COG3750	Belongs to the UPF0335 family
CP97_RS00850	COG0469	pyruvate kinase activity
CP97_RS00870	COG2095	MarC family integral membrane protein
CP97_RS00880	COG0762	integral membrane protein
CP97_RS00885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP97_RS00920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP97_RS00960	COG1131	(ABC) transporter
CP97_RS00995	COG0519	Catalyzes the synthesis of GMP from XMP
CP97_RS00995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CP97_RS01005	COG0628	permease
CP97_RS01030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP97_RS01040	COG1960	acyl-CoA dehydrogenase activity
CP97_RS01055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CP97_RS01060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CP97_RS01080	COG0352	thiamine-phosphate diphosphorylase activity
CP97_RS01085	COG1674	ftsk spoiiie
CP97_RS01090	COG0189	ligase activity
CP97_RS01090	COG4067	protein conserved in archaea
CP97_RS01095	COG0189	ligase activity
CP97_RS01120	COG0686	Belongs to the AlaDH PNT family
CP97_RS01125	COG3706	GGDEF domain
CP97_RS01155	COG2205	protein histidine kinase activity
CP97_RS01160	COG0433	COG0433 Predicted ATPase
CP97_RS01170	COG0436	Aminotransferase
CP97_RS01175	COG0564	pseudouridine synthase activity
CP97_RS01185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP97_RS01205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CP97_RS01215	COG0514	ATP-dependent DNA helicase (RecQ)
CP97_RS01230	COG3186	Phenylalanine-4-hydroxylase
CP97_RS01240	COG1968	undecaprenyl-diphosphatase activity
CP97_RS01245	COG3590	peptidase
CP97_RS01250	COG1132	(ABC) transporter
CP97_RS01275	COG0297	glycogen (starch) synthase activity
CP97_RS01285	COG0069	glutamate synthase activity
CP97_RS01285	COG0067	glutamate synthase
CP97_RS01285	COG0070	glutamate synthase
CP97_RS01300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP97_RS01305	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CP97_RS01345	COG2264	protein methyltransferase activity
CP97_RS01360	COG1132	(ABC) transporter
CP97_RS01440	COG3206	protein involved in exopolysaccharide biosynthesis
CP97_RS01440	COG0489	protein tyrosine kinase activity
CP97_RS01465	COG1215	transferase activity, transferring glycosyl groups
CP97_RS01490	COG0495	leucyl-tRNA aminoacylation
CP97_RS01505	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS01530	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CP97_RS01535	COG0739	heme binding
CP97_RS01540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CP97_RS01545	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CP97_RS01560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CP97_RS01570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP97_RS01585	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CP97_RS01590	COG4152	abc transporter atp-binding protein
CP97_RS01615	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CP97_RS01630	COG0776	regulation of translation
CP97_RS01635	COG2188	Transcriptional regulator
CP97_RS01640	COG3104	oligopeptide transport
CP97_RS01645	COG1228	amidohydrolase
CP97_RS01660	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CP97_RS01670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP97_RS01675	COG0138	bifunctional purine biosynthesis protein purh
CP97_RS01685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CP97_RS01705	COG1473	amidohydrolase
CP97_RS01735	COG0667	Aldo Keto reductase
CP97_RS01755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP97_RS01760	COG0457	Tetratricopeptide repeat
CP97_RS01765	COG4771	TonB-dependent receptor
CP97_RS01775	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS01825	COG3275	phosphorelay sensor kinase activity
CP97_RS01830	COG3279	Response regulator of the LytR AlgR family
CP97_RS01845	COG0590	tRNA wobble adenosine to inosine editing
CP97_RS01850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP97_RS01870	COG1570	exodeoxyribonuclease VII activity
CP97_RS01875	COG0151	Belongs to the GarS family
CP97_RS01880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP97_RS01900	COG0316	Belongs to the HesB IscA family
CP97_RS01905	COG2151	metal-sulfur cluster biosynthetic enzyme
CP97_RS01910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP97_RS01920	COG0719	Fe-S assembly protein
CP97_RS01925	COG0396	ATPase activity
CP97_RS01935	COG0719	Fe-S assembly protein
CP97_RS01950	COG0167	dihydroorotate dehydrogenase activity
CP97_RS01955	COG0405	Gamma-glutamyltransferase
CP97_RS01960	COG1022	Amp-dependent synthetase and ligase
CP97_RS01970	COG2022	thiamine diphosphate biosynthetic process
CP97_RS01980	COG1612	heme a metabolic process
CP97_RS01985	COG1324	tolerance protein
CP97_RS01990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CP97_RS01995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CP97_RS02000	COG0784	Response regulator, receiver
CP97_RS02025	COG3275	phosphorelay sensor kinase activity
CP97_RS02035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP97_RS02065	COG0316	Belongs to the HesB IscA family
CP97_RS02075	COG3773	Cell wall hydrolase
CP97_RS02075	COG3409	Peptidoglycan-binding domain 1 protein
CP97_RS02095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CP97_RS02100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CP97_RS02105	COG0237	dephospho-CoA kinase activity
CP97_RS02110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP97_RS02115	COG0424	maF-like protein
CP97_RS02120	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CP97_RS02125	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CP97_RS02130	COG1981	membrane
CP97_RS02135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CP97_RS02155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CP97_RS02160	COG0445	tRNA wobble uridine modification
CP97_RS02165	COG0357	Ribosomal RNA small subunit methyltransferase G
CP97_RS02185	COG1956	GAF domain-containing protein
CP97_RS02215	COG1329	Transcriptional regulator
CP97_RS02220	COG1295	ribonuclease BN
CP97_RS02225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CP97_RS02230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CP97_RS02240	COG0739	heme binding
CP97_RS02245	COG0113	porphobilinogen synthase activity
CP97_RS02260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CP97_RS02265	COG1793	dna ligase
CP97_RS02290	COG1063	alcohol dehydrogenase
CP97_RS02300	COG0438	transferase activity, transferring glycosyl groups
CP97_RS02315	COG0739	heme binding
CP97_RS02320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CP97_RS02325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CP97_RS02330	COG0799	negative regulation of ribosome biogenesis
CP97_RS02335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CP97_RS02345	COG0793	Belongs to the peptidase S41A family
CP97_RS02355	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CP97_RS02365	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CP97_RS02370	COG1295	ribonuclease BN
CP97_RS02375	COG0484	heat shock protein binding
CP97_RS02380	COG0259	pyridoxamine-phosphate oxidase activity
CP97_RS02405	COG0482	sulfurtransferase activity
CP97_RS02425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP97_RS02435	COG2733	membrane
CP97_RS02450	COG2086	electron transfer activity
CP97_RS02460	COG0045	succinate-CoA ligase (ADP-forming) activity
CP97_RS02465	COG0483	inositol monophosphate 1-phosphatase activity
CP97_RS02475	COG1253	flavin adenine dinucleotide binding
CP97_RS02485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CP97_RS02490	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CP97_RS02495	COG0196	riboflavin kinase activity
CP97_RS02510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CP97_RS02520	COG0588	phosphoglycerate mutase activity
CP97_RS02530	COG3665	Urea carboxylase-associated protein
CP97_RS02585	COG0308	aminopeptidase N
CP97_RS02590	COG1496	oxidoreductase activity
CP97_RS02605	COG2857	Cytochrome c1
CP97_RS02605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP97_RS02610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CP97_RS02630	COG0582	viral genome integration into host DNA
CP97_RS02660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CP97_RS02665	COG1192	Involved in chromosome partitioning
CP97_RS02690	COG1201	RNA secondary structure unwinding
CP97_RS02740	COG1494	fructose-1,6-bisphosphatase
CP97_RS02755	COG0483	inositol monophosphate 1-phosphatase activity
CP97_RS02760	COG3920	Histidine kinase
CP97_RS02765	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CP97_RS02770	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CP97_RS02775	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CP97_RS02780	COG0072	phenylalanine-tRNA ligase activity
CP97_RS02795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CP97_RS02810	COG0347	Belongs to the P(II) protein family
CP97_RS02815	COG0004	ammonium transporteR
CP97_RS02820	COG2885	chlorophyll binding
CP97_RS02825	COG1278	Cold shock
CP97_RS02830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP97_RS02835	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CP97_RS02850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CP97_RS02855	COG2032	superoxide dismutase activity
CP97_RS02925	COG4695	Portal protein
CP97_RS02945	COG0156	8-amino-7-oxononanoate synthase activity
CP97_RS03010	COG3483	tryptophan 2,3-dioxygenase activity
CP97_RS03025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP97_RS03050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CP97_RS03055	COG0280	phosphate acetyltransferase
CP97_RS03055	COG0281	malic enzyme
CP97_RS03060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP97_RS03090	COG1309	transcriptional regulator
CP97_RS03100	COG2146	nitrite reductase [NAD(P)H] activity
CP97_RS03110	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_RS03120	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CP97_RS03135	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_RS03145	COG3971	2-oxopent-4-enoate hydratase activity
CP97_RS03150	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CP97_RS03155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP97_RS03195	COG1595	DNA-templated transcription, initiation
CP97_RS03205	COG0729	surface antigen
CP97_RS03210	COG1959	2 iron, 2 sulfur cluster binding
CP97_RS03210	COG1295	ribonuclease BN
CP97_RS03215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CP97_RS03220	COG0730	response to heat
CP97_RS03225	COG0745	RESPONSE REGULATOR receiver
CP97_RS03235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CP97_RS03235	COG1017	nitric oxide dioxygenase activity
CP97_RS03250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CP97_RS03255	COG1137	ATPase activity
CP97_RS03265	COG0668	transmembrane transport
CP97_RS03275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CP97_RS03280	COG0124	histidyl-tRNA synthetase
CP97_RS03285	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CP97_RS03290	COG2890	protein-(glutamine-N5) methyltransferase activity
CP97_RS03300	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CP97_RS03305	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CP97_RS03310	COG2311	Membrane
CP97_RS03330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CP97_RS03335	COG0668	transmembrane transport
CP97_RS03340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP97_RS03340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP97_RS03365	COG3667	copper resistance
CP97_RS03370	COG2132	Multicopper oxidase
CP97_RS03375	COG1937	Protein conserved in bacteria
CP97_RS03405	COG0459	protein refolding
CP97_RS03410	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CP97_RS03415	COG0534	Mate efflux family protein
CP97_RS03430	COG0222	ribosome binding
CP97_RS03435	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CP97_RS03445	COG3655	Transcriptional regulator
CP97_RS03455	COG0085	RNA polymerase activity
CP97_RS03460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CP97_RS03475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP97_RS03475	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CP97_RS03490	COG0717	Belongs to the dCTP deaminase family
CP97_RS03525	COG2884	Cell division ATP-binding protein ftsE
CP97_RS03545	COG0076	glutamate decarboxylase activity
CP97_RS03580	COG1024	Enoyl-CoA hydratase
CP97_RS03585	COG0287	Prephenate dehydrogenase
CP97_RS03590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP97_RS03595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP97_RS03600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP97_RS03600	COG2813	Specifically methylates the guanine in position
CP97_RS03610	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CP97_RS03615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CP97_RS03635	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP97_RS03640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP97_RS03655	COG0330	HflC and HflK could
CP97_RS03660	COG0489	protein tyrosine kinase activity
CP97_RS03670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CP97_RS03680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CP97_RS03680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CP97_RS03685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP97_RS03720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP97_RS03765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP97_RS03765	COG1213	nucleotidyl transferase
CP97_RS03780	COG1260	myo-inositol-1-phosphate synthase
CP97_RS03785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CP97_RS03800	COG0800	Aldolase
CP97_RS03805	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS03810	COG2271	Major facilitator Superfamily
CP97_RS03830	COG2186	Transcriptional regulator
CP97_RS03895	COG4964	Belongs to the GSP D family
CP97_RS03910	COG3293	Transposase
CP97_RS03945	COG1218	3'(2'),5'-bisphosphate nucleotidase
CP97_RS03955	COG0175	sulfate reduction
CP97_RS03965	COG1482	cell wall glycoprotein biosynthetic process
CP97_RS03995	COG1758	RNA polymerase activity
CP97_RS04000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP97_RS04005	COG1597	lipid kinase activity
CP97_RS04010	COG0305	Participates in initiation and elongation during chromosome replication
CP97_RS04015	COG5328	Belongs to the UPF0262 family
CP97_RS04030	COG2866	Carboxypeptidase
CP97_RS04045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP97_RS04065	COG0606	chelatase, subunit chli
CP97_RS04080	COG0594	ribonuclease P activity
CP97_RS04085	COG0706	membrane insertase activity
CP97_RS04090	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CP97_RS04105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP97_RS04110	COG1301	dicarboxylic acid transport
CP97_RS04130	COG0501	Belongs to the peptidase M48B family
CP97_RS04135	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CP97_RS04140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP97_RS04150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CP97_RS04155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CP97_RS04160	COG0268	Binds directly to 16S ribosomal RNA
CP97_RS04165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP97_RS04170	COG2226	methyltransferase
CP97_RS04175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP97_RS04190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CP97_RS04195	COG0756	dUTP diphosphatase activity
CP97_RS04205	COG0180	Tryptophanyl-tRNA synthetase
CP97_RS04210	COG0728	peptidoglycan biosynthetic process
CP97_RS04215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CP97_RS04240	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CP97_RS04245	COG3634	alkyl hydroperoxide reductase activity
CP97_RS04250	COG0450	alkyl hydroperoxide reductase
CP97_RS04255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CP97_RS04260	COG0632	four-way junction helicase activity
CP97_RS04270	COG2255	four-way junction helicase activity
CP97_RS04280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CP97_RS04295	COG2989	Protein conserved in bacteria
CP97_RS04315	COG0123	including yeast histone deacetylase and acetoin utilization protein
CP97_RS04320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP97_RS04330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP97_RS04330	COG0475	glutathione-regulated potassium exporter activity
CP97_RS04365	COG0714	Associated with various cellular activities
CP97_RS04385	COG0077	Prephenate dehydratase
CP97_RS04390	COG3474	cytochrome
CP97_RS04395	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CP97_RS04420	COG2226	methyltransferase
CP97_RS04445	COG0457	Tetratricopeptide repeat
CP97_RS04450	COG4771	TonB-dependent receptor
CP97_RS04465	COG0352	thiamine-phosphate diphosphorylase activity
CP97_RS04465	COG0351	phosphomethylpyrimidine kinase
CP97_RS04475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP97_RS04500	COG3920	Histidine kinase
CP97_RS04525	COG1987	bacterial-type flagellum assembly
CP97_RS04540	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CP97_RS04575	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CP97_RS04585	COG1677	Flagellar hook-basal body complex protein FliE
CP97_RS04595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CP97_RS04620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CP97_RS04625	COG4786	Flagellar basal body rod
CP97_RS04625	COG1256	bacterial-type flagellum assembly
CP97_RS04635	COG1706	bacterial-type flagellum-dependent cell motility
CP97_RS04640	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CP97_RS04650	COG4787	bacterial-type flagellum-dependent cell motility
CP97_RS04660	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CP97_RS04675	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CP97_RS04715	COG0725	ABC transporter, periplasmic molybdate-binding protein
CP97_RS04720	COG4149	molybdate abc transporter
CP97_RS04725	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CP97_RS04730	COG1309	transcriptional regulator
CP97_RS04745	COG2814	Major facilitator Superfamily
CP97_RS04755	COG1215	transferase activity, transferring glycosyl groups
CP97_RS04765	COG4771	TonB-dependent receptor
CP97_RS04785	COG0436	Aminotransferase
CP97_RS04790	COG3243	poly(R)-hydroxyalkanoic acid synthase
CP97_RS04800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CP97_RS04835	COG0784	Response regulator, receiver
CP97_RS04840	COG0534	Mate efflux family protein
CP97_RS04845	COG2080	2 iron, 2 sulfur cluster binding
CP97_RS04870	COG0321	lipoyl(octanoyl) transferase activity
CP97_RS04900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP97_RS04905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP97_RS04920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP97_RS04935	COG0037	tRNA processing
CP97_RS04950	COG0800	Aldolase
CP97_RS04955	COG0837	glucose binding
CP97_RS04960	COG0129	dihydroxy-acid dehydratase activity
CP97_RS04965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CP97_RS04975	COG0432	Pfam Uncharacterised protein family UPF0047
CP97_RS04990	COG1404	Belongs to the peptidase S8 family
CP97_RS05000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP97_RS05015	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CP97_RS05020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CP97_RS05040	COG0741	lytic transglycosylase activity
CP97_RS05055	COG4974	Belongs to the 'phage' integrase family
CP97_RS05060	COG4974	Belongs to the 'phage' integrase family
CP97_RS05065	COG4974	Belongs to the 'phage' integrase family
CP97_RS05075	COG1475	DNA binding
CP97_RS05080	COG4227	nucleotidyltransferase activity
CP97_RS05110	COG0629	single-stranded DNA binding
CP97_RS05125	COG0582	viral genome integration into host DNA
CP97_RS05160	COG0629	single-stranded DNA binding
CP97_RS05370	COG1937	Protein conserved in bacteria
CP97_RS05375	COG2801	Transposase and inactivated derivatives
CP97_RS05375	COG3415	Transposase
CP97_RS05385	COG1304	FMN binding
CP97_RS05400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP97_RS05430	COG0672	)-iron permease
CP97_RS05450	COG3293	Transposase
CP97_RS05455	COG3293	Transposase
CP97_RS05500	COG1620	l-lactate permease
CP97_RS05505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP97_RS05515	COG0427	acetyl-CoA hydrolase
CP97_RS05520	COG2801	Transposase and inactivated derivatives
CP97_RS05535	COG0589	response to stress
CP97_RS05540	COG3415	Transposase
CP97_RS05540	COG2801	Transposase and inactivated derivatives
CP97_RS05580	COG3920	Histidine kinase
CP97_RS05605	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP97_RS05610	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CP97_RS05615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CP97_RS05625	COG1960	acyl-CoA dehydrogenase activity
CP97_RS05630	COG2217	Heavy metal translocating P-type atpase
CP97_RS05640	COG0596	Alpha beta hydrolase
CP97_RS05645	COG1620	l-lactate permease
CP97_RS05650	COG0475	glutathione-regulated potassium exporter activity
CP97_RS05655	COG0574	Belongs to the PEP-utilizing enzyme family
CP97_RS05655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP97_RS05660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP97_RS05685	COG3459	Glycosyltransferase 36 associated
CP97_RS05715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP97_RS05720	COG0670	Belongs to the BI1 family
CP97_RS05730	COG0033	Phosphoglucomutase
CP97_RS05735	COG0129	dihydroxy-acid dehydratase activity
CP97_RS05745	COG3588	fructose-bisphosphate aldolase
CP97_RS05770	COG2132	Multicopper oxidase
CP97_RS05855	COG2217	Heavy metal translocating P-type atpase
CP97_RS05865	COG1937	Protein conserved in bacteria
CP97_RS05880	COG2801	Transposase and inactivated derivatives
CP97_RS05880	COG3415	Transposase
CP97_RS05905	COG0616	signal peptide processing
CP97_RS05910	COG0540	Belongs to the ATCase OTCase family
CP97_RS05915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP97_RS05920	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS05945	COG2311	Membrane
CP97_RS05970	COG0746	molybdenum cofactor guanylyltransferase activity
CP97_RS05975	COG3383	formate dehydrogenase (NAD+) activity
CP97_RS05980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CP97_RS06005	COG1024	Enoyl-CoA hydratase
CP97_RS06025	COG2197	response regulator
CP97_RS06030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP97_RS06035	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP97_RS06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP97_RS06070	COG0438	transferase activity, transferring glycosyl groups
CP97_RS06100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP97_RS06115	COG0438	transferase activity, transferring glycosyl groups
CP97_RS06125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP97_RS06135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CP97_RS06145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP97_RS06150	COG0463	Glycosyl transferase, family 2
CP97_RS06170	COG5001	Diguanylate cyclase
CP97_RS06180	COG3437	response regulator, receiver
CP97_RS06205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP97_RS06210	COG0737	Belongs to the 5'-nucleotidase family
CP97_RS06225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CP97_RS06250	COG5002	protein histidine kinase activity
CP97_RS06260	COG0745	RESPONSE REGULATOR receiver
CP97_RS06265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CP97_RS06275	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP97_RS06280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP97_RS06285	COG0625	glutathione transferase activity
CP97_RS06290	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CP97_RS06305	COG0577	efflux transmembrane transporter activity
CP97_RS06305	COG1136	(ABC) transporter
CP97_RS06310	COG0577	efflux transmembrane transporter activity
CP97_RS06310	COG1136	(ABC) transporter
CP97_RS06335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP97_RS06340	COG2885	chlorophyll binding
CP97_RS06340	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CP97_RS06345	COG1960	acyl-CoA dehydrogenase activity
CP97_RS06370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP97_RS06375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CP97_RS06380	COG0181	hydroxymethylbilane synthase activity
CP97_RS06395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP97_RS06410	COG0556	nucleotide-excision repair
CP97_RS06430	COG0596	Alpha beta hydrolase
CP97_RS06430	COG2226	methyltransferase
CP97_RS06430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP97_RS06435	COG2308	Evidence 4 Homologs of previously reported genes of
CP97_RS06455	COG4566	intracellular signal transduction
CP97_RS06465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CP97_RS06470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP97_RS06475	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CP97_RS06480	COG0656	L-ascorbic acid biosynthetic process
CP97_RS06485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CP97_RS06495	COG0252	asparaginase activity
CP97_RS06510	COG0165	Argininosuccinate lyase
CP97_RS06520	COG0019	diaminopimelate decarboxylase activity
CP97_RS06525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP97_RS06525	COG1648	precorrin-2 dehydrogenase activity
CP97_RS06530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CP97_RS06540	COG0628	permease
CP97_RS06550	COG0736	holo-[acyl-carrier-protein] synthase activity
CP97_RS06555	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CP97_RS06560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CP97_RS06565	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CP97_RS06570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP97_RS06575	COG0109	protoheme IX farnesyltransferase activity
CP97_RS06585	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CP97_RS06630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP97_RS06640	COG0314	molybdopterin synthase activity
CP97_RS06655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CP97_RS06660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CP97_RS06685	COG0418	dihydroorotase activity
CP97_RS06695	COG1012	belongs to the aldehyde dehydrogenase family
CP97_RS06700	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CP97_RS06730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CP97_RS06750	COG0789	Transcriptional regulator
CP97_RS06775	COG1194	a g-specific adenine glycosylase
CP97_RS06790	COG2816	NAD+ diphosphatase activity
CP97_RS06805	COG2239	Acts as a magnesium transporter
CP97_RS06815	COG0583	DNA-binding transcription factor activity
CP97_RS06820	COG1253	flavin adenine dinucleotide binding
CP97_RS06825	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CP97_RS06835	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP97_RS06850	COG4957	zinc ion binding
CP97_RS06855	COG1247	-acetyltransferase
CP97_RS06870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CP97_RS06875	COG0612	Peptidase, M16
CP97_RS06880	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CP97_RS06890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CP97_RS06895	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CP97_RS06915	COG0625	glutathione transferase activity
CP97_RS06925	COG1054	Belongs to the UPF0176 family
CP97_RS06935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP97_RS06960	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CP97_RS06975	COG1381	Involved in DNA repair and RecF pathway recombination
CP97_RS06980	COG0473	3-isopropylmalate dehydrogenase activity
CP97_RS07000	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CP97_RS07010	COG2967	ApaG domain
CP97_RS07015	COG0583	DNA-binding transcription factor activity
CP97_RS07025	COG2197	response regulator
CP97_RS07050	COG2801	Transposase and inactivated derivatives
CP97_RS07075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CP97_RS07080	COG0049	tRNA binding
CP97_RS07085	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP97_RS07090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP97_RS07100	COG0051	transcription antitermination factor activity, RNA binding
CP97_RS07105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CP97_RS07110	COG0088	Forms part of the polypeptide exit tunnel
CP97_RS07115	COG0089	rRNA binding
CP97_RS07120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CP97_RS07125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CP97_RS07130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CP97_RS07135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CP97_RS07140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CP97_RS07145	COG0255	Belongs to the universal ribosomal protein uL29 family
CP97_RS07150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CP97_RS07155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CP97_RS07160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CP97_RS07165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CP97_RS07170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP97_RS07175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CP97_RS07180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CP97_RS07185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CP97_RS07190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CP97_RS07195	COG1841	ribosomal large subunit assembly
CP97_RS07200	COG0200	Binds to the 23S rRNA
CP97_RS07205	COG0201	protein transport
CP97_RS07210	COG0563	adenylate kinase activity
CP97_RS07220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CP97_RS07225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CP97_RS07230	COG0202	RNA polymerase activity
CP97_RS07235	COG0203	ribosomal protein L17
CP97_RS07240	COG1505	serine-type exopeptidase activity
CP97_RS07275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP97_RS07280	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP97_RS07285	COG0567	Dehydrogenase, E1 component
CP97_RS07290	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CP97_RS07300	COG0039	L-malate dehydrogenase activity
CP97_RS07315	COG4771	TonB-dependent receptor
CP97_RS07330	COG1120	ATPase activity
CP97_RS07335	COG0339	signal peptide processing
CP97_RS07350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CP97_RS07360	COG2801	Transposase and inactivated derivatives
CP97_RS07380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP97_RS07395	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CP97_RS07405	COG0137	argininosuccinate synthase activity
CP97_RS07415	COG0534	Mate efflux family protein
CP97_RS07420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP97_RS07430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP97_RS07455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CP97_RS07475	COG2268	Band 7 protein
CP97_RS07490	COG0741	lytic transglycosylase activity
CP97_RS07495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP97_RS07505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CP97_RS07530	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CP97_RS07535	COG2890	protein-(glutamine-N5) methyltransferase activity
CP97_RS07540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP97_RS07555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP97_RS07560	COG3153	acetyltransferase
CP97_RS07560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP97_RS07565	COG0538	isocitrate dehydrogenase activity
CP97_RS07585	COG2070	2-Nitropropane dioxygenase
CP97_RS07590	COG1960	acyl-CoA dehydrogenase activity
CP97_RS07595	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP97_RS07595	COG1024	Enoyl-CoA hydratase
CP97_RS07600	COG0183	Belongs to the thiolase family
CP97_RS07605	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_RS07650	COG0210	DNA helicase
CP97_RS07660	COG0742	ribosomal rna small subunit methyltransferase
CP97_RS07665	COG1187	pseudouridine synthase activity
CP97_RS07670	COG2223	nitrite transmembrane transporter activity
CP97_RS07675	COG0285	dihydrofolate synthase activity
CP97_RS07680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CP97_RS07685	COG0159	tryptophan synthase activity
CP97_RS07690	COG0133	tryptophan synthase activity
CP97_RS07695	COG0135	phosphoribosylanthranilate isomerase activity
CP97_RS07705	COG0284	orotidine-5'-phosphate decarboxylase activity
CP97_RS07715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP97_RS07720	COG2003	Belongs to the UPF0758 family
CP97_RS07745	COG0356	it plays a direct role in the translocation of protons across the membrane
CP97_RS07750	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP97_RS07755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP97_RS07760	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP97_RS07765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP97_RS07770	COG0539	negative regulation of cytoplasmic translation
CP97_RS07775	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CP97_RS07785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP97_RS07800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CP97_RS07805	COG0228	four-way junction DNA binding
CP97_RS07810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CP97_RS07820	COG0336	Belongs to the RNA methyltransferase TrmD family
CP97_RS07825	COG0335	large ribosomal subunit rRNA binding
CP97_RS07830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CP97_RS07850	COG0659	secondary active sulfate transmembrane transporter activity
CP97_RS07855	COG0359	binds to the 23S rRNA
CP97_RS07860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP97_RS07865	COG0360	Binds together with S18 to 16S ribosomal RNA
CP97_RS07870	COG2354	Protein conserved in bacteria
CP97_RS07880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP97_RS07890	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CP97_RS07910	COG0493	'glutamate synthase
CP97_RS07915	COG3300	MHYT domain
CP97_RS07915	COG5001	Diguanylate cyclase
CP97_RS07920	COG0481	GTPase activity
CP97_RS07960	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP97_RS07975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP97_RS07980	COG4221	oxidoreductase activity
CP97_RS07990	COG2264	protein methyltransferase activity
CP97_RS07995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP97_RS08000	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS08005	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CP97_RS08025	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CP97_RS08050	COG1595	DNA-templated transcription, initiation
CP97_RS08065	COG2321	neutral zinc metallopeptidase
CP97_RS08070	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS08095	COG1051	belongs to the nudix hydrolase family
CP97_RS08100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CP97_RS08100	COG0674	pyruvate-flavodoxin oxidoreductase activity
CP97_RS08105	COG1013	pyruvate-flavodoxin oxidoreductase activity
CP97_RS08115	COG0415	Belongs to the DNA photolyase family
CP97_RS08120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP97_RS08135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CP97_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS08155	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CP97_RS08170	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CP97_RS08200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CP97_RS08220	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CP97_RS08225	COG0126	phosphoglycerate kinase activity
CP97_RS08245	COG3588	fructose-bisphosphate aldolase
CP97_RS08250	COG0352	thiamine-phosphate diphosphorylase activity
CP97_RS08260	COG1376	ErfK ybiS ycfS ynhG family protein
CP97_RS08275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CP97_RS08280	COG0483	inositol monophosphate 1-phosphatase activity
CP97_RS08290	COG0471	metal ion transport
CP97_RS08290	COG3273	potassium ion transport
CP97_RS08300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP97_RS08310	COG2204	response regulator
CP97_RS08315	COG0385	Bile acid
CP97_RS08325	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CP97_RS08330	COG0733	neurotransmitter:sodium symporter activity
CP97_RS08350	COG1525	nuclease
CP97_RS08360	COG1609	Transcriptional regulator
CP97_RS08370	COG2205	protein histidine kinase activity
CP97_RS08375	COG1522	sequence-specific DNA binding
CP97_RS08385	COG0439	Biotin carboxylase
CP97_RS08390	COG0511	ligase activity, forming carbon-carbon bonds
CP97_RS08395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CP97_RS08410	COG1862	Preprotein translocase
CP97_RS08415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP97_RS08420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP97_RS08425	COG0438	transferase activity, transferring glycosyl groups
CP97_RS08445	COG0488	(ABC) transporter
CP97_RS08475	COG0287	Prephenate dehydrogenase
CP97_RS08475	COG1605	Chorismate mutase
CP97_RS08480	COG0142	geranyltranstransferase activity
CP97_RS08485	COG1643	Atp-dependent helicase
CP97_RS08495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CP97_RS08500	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CP97_RS08510	COG0776	regulation of translation
CP97_RS08515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP97_RS08545	COG4206	TonB-dependent receptor
CP97_RS08570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP97_RS08575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CP97_RS08585	COG1396	sequence-specific DNA binding
CP97_RS08585	COG3800	Transcriptional regulator
CP97_RS08590	COG0688	phosphatidylethanolamine metabolic process
CP97_RS08600	COG0052	Belongs to the universal ribosomal protein uS2 family
CP97_RS08605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CP97_RS08610	COG0528	UMP kinase activity
CP97_RS08615	COG0233	cytoplasmic translational termination
CP97_RS08620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP97_RS08630	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CP97_RS08635	COG0750	zinc metalloprotease
CP97_RS08640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP97_RS08650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CP97_RS08655	COG0254	rRNA binding
CP97_RS08685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP97_RS08690	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CP97_RS08695	COG1138	Cytochrome C-type biogenesis protein
CP97_RS08705	COG3088	subunit of a heme lyase
CP97_RS08715	COG3158	transport of potassium into the cell
CP97_RS08720	COG2917	probably involved in intracellular septation
CP97_RS08725	COG0552	protein localization to endoplasmic reticulum
CP97_RS08730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP97_RS08735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CP97_RS08740	COG3300	MHYT domain
CP97_RS08740	COG5001	Diguanylate cyclase
CP97_RS08750	COG0028	Belongs to the TPP enzyme family
CP97_RS08760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP97_RS08765	COG0583	DNA-binding transcription factor activity
CP97_RS08770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CP97_RS08775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CP97_RS08785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP97_RS08790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP97_RS08795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CP97_RS08815	COG1024	Enoyl-CoA hydratase
CP97_RS08835	COG1960	acyl-CoA dehydrogenase activity
CP97_RS08840	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS08850	COG0156	8-amino-7-oxononanoate synthase activity
CP97_RS08860	COG4106	trans-aconitate 2-methyltransferase activity
CP97_RS08875	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CP97_RS08880	COG1877	trehalose-phosphatase activity
CP97_RS08885	COG3387	PFAM Glycoside hydrolase 15-related
CP97_RS08890	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CP97_RS08905	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CP97_RS08925	COG1704	LemA family
CP97_RS08935	COG3300	MHYT domain
CP97_RS08935	COG5001	Diguanylate cyclase
CP97_RS08940	COG0156	8-amino-7-oxononanoate synthase activity
CP97_RS08945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CP97_RS08950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CP97_RS08955	COG0758	DNA mediated transformation
CP97_RS08965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CP97_RS08965	COG1754	DNA topoisomerase type I activity
CP97_RS08975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CP97_RS08980	COG0571	ribonuclease III activity
CP97_RS08990	COG0166	Belongs to the GPI family
CP97_RS08995	COG0513	Belongs to the DEAD box helicase family
CP97_RS09025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CP97_RS09030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP97_RS09045	COG4974	Belongs to the 'phage' integrase family
CP97_RS09050	COG0825	malonyl-CoA metabolic process
CP97_RS09055	COG4783	chaperone-mediated protein folding
CP97_RS09065	COG0494	nUDIX hydrolase
CP97_RS09080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP97_RS09085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CP97_RS09100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP97_RS09105	COG0302	gtp cyclohydrolase
CP97_RS09115	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CP97_RS09115	COG0678	peroxiredoxin activity
CP97_RS09120	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CP97_RS09125	COG2205	protein histidine kinase activity
CP97_RS09130	COG0802	atpase or kinase
CP97_RS09135	COG3178	'Phosphotransferase
CP97_RS09140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP97_RS09145	COG2887	Belongs to the helicase family. UvrD subfamily
CP97_RS09150	COG1074	ATP-dependent DNA helicase activity
CP97_RS09160	COG0483	inositol monophosphate 1-phosphatase activity
CP97_RS09165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CP97_RS09175	COG0653	protein targeting
CP97_RS09185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP97_RS09195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CP97_RS09210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CP97_RS09225	COG1136	(ABC) transporter
CP97_RS09260	COG0521	Mo-molybdopterin cofactor biosynthetic process
CP97_RS09280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CP97_RS09290	COG0129	dihydroxy-acid dehydratase activity
CP97_RS09300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CP97_RS09300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CP97_RS09305	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CP97_RS09330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP97_RS09360	COG3267	Type II secretory pathway component ExeA
CP97_RS09360	COG3409	Peptidoglycan-binding domain 1 protein
CP97_RS09385	COG0367	asparagine synthase
CP97_RS09390	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CP97_RS09405	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP97_RS09415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP97_RS09420	COG1530	ribonuclease E activity
CP97_RS09430	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CP97_RS09450	COG0004	ammonium transporteR
CP97_RS09465	COG0183	Belongs to the thiolase family
CP97_RS09475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP97_RS09480	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP97_RS09485	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP97_RS09490	COG0649	NAD binding
CP97_RS09495	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CP97_RS09500	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP97_RS09505	COG1034	ATP synthesis coupled electron transport
CP97_RS09510	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP97_RS09515	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP97_RS09525	COG0713	ATP synthesis coupled electron transport
CP97_RS09540	COG1007	ATP synthesis coupled electron transport
CP97_RS09550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CP97_RS09585	COG2205	protein histidine kinase activity
CP97_RS09590	COG0372	Belongs to the citrate synthase family
CP97_RS09595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP97_RS09600	COG2333	competence protein COMEC
CP97_RS09600	COG0658	competence protein
CP97_RS09605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CP97_RS09610	COG0303	'Molybdopterin
CP97_RS09615	COG0315	cyclic pyranopterin monophosphate synthase activity
CP97_RS09625	COG0134	indole-3-glycerol-phosphate synthase activity
CP97_RS09630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CP97_RS09645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP97_RS09650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CP97_RS09655	COG0149	triose-phosphate isomerase activity
CP97_RS09665	COG0504	CTP synthase activity
CP97_RS09670	COG0071	Belongs to the small heat shock protein (HSP20) family
CP97_RS09675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CP97_RS09675	COG0678	peroxiredoxin activity
CP97_RS09680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP97_RS09705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CP97_RS09710	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP97_RS09710	COG0022	dehydrogenase e1 component
CP97_RS09740	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CP97_RS09750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP97_RS09765	COG0012	GTP binding
CP97_RS09785	COG0193	aminoacyl-tRNA hydrolase activity
CP97_RS09790	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CP97_RS09820	COG0752	glycyl-tRNA synthetase alpha subunit
CP97_RS09825	COG0751	glycine-tRNA ligase activity
CP97_RS09830	COG0574	Belongs to the PEP-utilizing enzyme family
CP97_RS09830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP97_RS09845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CP97_RS09865	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CP97_RS09875	COG3876	Protein conserved in bacteria
CP97_RS09895	COG0187	DNA topoisomerase II activity
CP97_RS09900	COG3107	peptidoglycan biosynthetic process
CP97_RS09905	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CP97_RS09910	COG0792	nuclease activity
CP97_RS09915	COG0189	ligase activity
CP97_RS09920	COG0586	Pfam SNARE associated Golgi protein
CP97_RS09925	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CP97_RS09930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CP97_RS09940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CP97_RS09945	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CP97_RS09950	COG1420	regulation of RNA biosynthetic process
CP97_RS09955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CP97_RS09965	COG0456	acetyltransferase
CP97_RS09965	COG0454	-acetyltransferase
CP97_RS09980	COG0443	Heat shock 70 kDa protein
CP97_RS09985	COG0484	heat shock protein binding
CP97_RS09990	COG1752	Esterase of the alpha-beta hydrolase superfamily
CP97_RS10010	COG0477	Major facilitator Superfamily
CP97_RS10015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CP97_RS10025	COG0442	prolyl-tRNA aminoacylation
CP97_RS10035	COG2234	aminopeptidase activity
CP97_RS10040	COG0557	exoribonuclease II activity
CP97_RS10055	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP97_RS10060	COG1607	acyl-coa hydrolase
CP97_RS10065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP97_RS10080	COG2951	lytic endotransglycosylase activity
CP97_RS10090	COG1686	Belongs to the peptidase S11 family
CP97_RS10095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CP97_RS10100	COG0470	DNA polymerase III
CP97_RS10105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP97_RS10110	COG0084	hydrolase, TatD family'
CP97_RS10115	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CP97_RS10115	COG0321	lipoyl(octanoyl) transferase activity
CP97_RS10120	COG3956	TIGRFAM MazG family protein
CP97_RS10125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CP97_RS10135	COG2204	response regulator
CP97_RS10140	COG5000	phosphorelay sensor kinase activity
CP97_RS10145	COG2204	response regulator
CP97_RS10170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CP97_RS10170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CP97_RS10175	COG1058	Belongs to the CinA family
CP97_RS10175	COG1546	Belongs to the CinA family
CP97_RS10180	COG2867	negative regulation of translational initiation
CP97_RS10185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CP97_RS10190	COG0288	reversible hydration of carbon dioxide
CP97_RS10215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CP97_RS10240	COG0772	Belongs to the SEDS family
CP97_RS10250	COG1396	sequence-specific DNA binding
CP97_RS10250	COG3800	Transcriptional regulator
CP97_RS10255	COG2205	protein histidine kinase activity
CP97_RS10270	COG1366	Belongs to the anti-sigma-factor antagonist family
CP97_RS10275	COG1366	Belongs to the anti-sigma-factor antagonist family
CP97_RS10285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CP97_RS10295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CP97_RS10305	COG0148	phosphopyruvate hydratase activity
CP97_RS10345	COG2801	Transposase and inactivated derivatives
CP97_RS10355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP97_RS10370	COG0505	Belongs to the CarA family
CP97_RS10385	COG0358	DNA primase activity
CP97_RS10390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP97_RS10410	COG0698	ribose 5-phosphate isomerase
CP97_RS10415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP97_RS10425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CP97_RS10435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CP97_RS10445	COG0343	queuine tRNA-ribosyltransferase activity
CP97_RS10455	COG0842	Transport permease protein
CP97_RS10460	COG1131	(ABC) transporter
CP97_RS10465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CP97_RS10475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CP97_RS10480	COG0142	geranyltranstransferase activity
CP97_RS10485	COG1722	exodeoxyribonuclease VII activity
CP97_RS10490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP97_RS10510	COG0560	Phosphoserine phosphatase
CP97_RS10515	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CP97_RS10520	COG0028	Belongs to the TPP enzyme family
CP97_RS10525	COG0440	acetolactate synthase activity
CP97_RS10535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CP97_RS10540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP97_RS10545	COG0784	Response regulator, receiver
CP97_RS10545	COG2205	protein histidine kinase activity
CP97_RS10560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CP97_RS10575	COG5002	protein histidine kinase activity
CP97_RS10580	COG3746	phosphate-selective porin O and P
CP97_RS10590	COG0573	inorganic phosphate transmembrane transporter activity
CP97_RS10600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP97_RS10605	COG0704	Plays a role in the regulation of phosphate uptake
CP97_RS10610	COG0745	RESPONSE REGULATOR receiver
CP97_RS10620	COG0587	DNA-directed DNA polymerase activity
CP97_RS10635	COG1253	flavin adenine dinucleotide binding
CP97_RS10650	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CP97_RS10655	COG2323	membrane
CP97_RS10690	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CP97_RS10695	COG0668	transmembrane transport
CP97_RS10705	COG1199	ATP-dependent helicase activity
CP97_RS10720	COG0776	regulation of translation
CP97_RS10725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP97_RS10730	COG0416	fatty acid biosynthetic process
CP97_RS10735	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CP97_RS10745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP97_RS10765	COG0215	cysteine-tRNA ligase activity
CP97_RS10805	COG0646	methionine synthase
CP97_RS10805	COG1410	methionine synthase
CP97_RS10815	COG2169	Transcriptional regulator
CP97_RS10815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP97_RS10825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP97_RS10830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CP97_RS10835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CP97_RS10845	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CP97_RS10850	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CP97_RS10930	COG0702	epimerase
CP97_RS10935	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CP97_RS10945	COG1404	Belongs to the peptidase S8 family
CP97_RS10970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CP97_RS10975	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CP97_RS10980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CP97_RS10985	COG2133	pyrroloquinoline quinone binding
CP97_RS11000	COG0494	nUDIX hydrolase
CP97_RS11005	COG0617	tRNA 3'-terminal CCA addition
CP97_RS11015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP97_RS11020	COG0693	protein deglycase activity
CP97_RS11035	COG0596	Alpha beta hydrolase
CP97_RS11045	COG1104	cysteine desulfurase activity
CP97_RS11080	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CP97_RS11085	COG0745	RESPONSE REGULATOR receiver
CP97_RS11090	COG2205	protein histidine kinase activity
CP97_RS11100	COG1660	Displays ATPase and GTPase activities
CP97_RS11105	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP97_RS11105	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP97_RS11115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP97_RS11125	COG1322	Protein conserved in bacteria
CP97_RS11145	COG0242	peptide deformylase activity
CP97_RS11150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CP97_RS11155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP97_RS11160	COG0101	tRNA pseudouridine synthase activity
CP97_RS11170	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CP97_RS11175	COG2234	aminopeptidase activity
CP97_RS11220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CP97_RS11225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CP97_RS11230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CP97_RS11235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CP97_RS11240	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CP97_RS11255	COG1946	Acyl-CoA thioesterase
CP97_RS11270	COG0322	excinuclease ABC activity
CP97_RS11275	COG0531	amino acid
CP97_RS11280	COG2081	HI0933 family
CP97_RS11290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CP97_RS11295	COG0424	maF-like protein
CP97_RS11320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CP97_RS11325	COG0612	Peptidase, M16
CP97_RS11335	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP97_RS11340	COG0047	phosphoribosylformylglycinamidine synthase activity
CP97_RS11345	COG5001	Diguanylate cyclase
CP97_RS11350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP97_RS11360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP97_RS11365	COG0546	phosphoglycolate phosphatase activity
CP97_RS11375	COG1045	serine acetyltransferase
CP97_RS11390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CP97_RS11395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CP97_RS11405	COG0105	UTP biosynthetic process
CP97_RS11420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CP97_RS11425	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CP97_RS11430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CP97_RS11435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CP97_RS11440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP97_RS11455	COG3724	N-succinylarginine dihydrolase activity
CP97_RS11465	COG1970	mechanosensitive ion channel activity
CP97_RS11470	COG1970	mechanosensitive ion channel activity
CP97_RS11495	COG0572	uridine kinase
CP97_RS11500	COG4566	intracellular signal transduction
CP97_RS11505	COG0793	Belongs to the peptidase S41A family
CP97_RS11505	COG4946	Tricorn protease homolog
CP97_RS11515	COG2030	dehydratase
CP97_RS11550	COG2801	Transposase and inactivated derivatives
CP97_RS11605	COG0842	Transport permease protein
CP97_RS11630	COG1185	polyribonucleotide nucleotidyltransferase activity
CP97_RS11635	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CP97_RS11640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CP97_RS11645	COG1994	Peptidase M50
CP97_RS11650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CP97_RS11665	COG1435	thymidine kinase activity
CP97_RS11670	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CP97_RS11680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CP97_RS11695	COG0779	Required for maturation of 30S ribosomal subunits
CP97_RS11705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CP97_RS11715	COG1842	Phage shock protein A
CP97_RS11760	COG2166	iron-sulfur cluster assembly
CP97_RS11790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CP97_RS11805	COG0066	3-isopropylmalate dehydratase activity
CP97_RS11820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CP97_RS11835	COG1012	belongs to the aldehyde dehydrogenase family
CP97_RS11845	COG0457	Tetratricopeptide repeat
CP97_RS11855	COG4206	TonB-dependent receptor
CP97_RS11870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CP97_RS11875	COG0484	heat shock protein binding
CP97_RS11885	COG4181	ATPase activity
CP97_RS11895	COG3152	Membrane
CP97_RS11900	COG1714	RDD family
CP97_RS11905	COG4771	TonB-dependent receptor
CP97_RS11910	COG1217	gtp-binding protein TYPA
CP97_RS11930	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CP97_RS11945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP97_RS11950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CP97_RS11960	COG2897	thiosulfate sulfurtransferase activity
CP97_RS11965	COG0626	cystathionine gamma-synthase activity
CP97_RS11970	COG0668	transmembrane transport
CP97_RS11975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP97_RS11975	COG1648	precorrin-2 dehydrogenase activity
CP97_RS11985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP97_RS11995	COG0175	sulfate reduction
CP97_RS12015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CP97_RS12020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CP97_RS12035	COG0670	Belongs to the BI1 family
CP97_RS12040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CP97_RS12060	COG0849	cell division
CP97_RS12065	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CP97_RS12070	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP97_RS12075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CP97_RS12080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP97_RS12085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CP97_RS12095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP97_RS12100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP97_RS12105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CP97_RS12110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CP97_RS12125	COG0275	rRNA processing
CP97_RS12145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP97_RS12165	COG2154	pterin-4-alpha-carbinolamine dehydratase
CP97_RS12170	COG4133	protoheme IX ABC transporter activity
CP97_RS12175	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP97_RS12185	COG0024	Methionine aminopeptidase
CP97_RS12195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CP97_RS12215	COG0174	glutamine synthetase
CP97_RS12240	COG0729	surface antigen
CP97_RS12245	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CP97_RS12250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CP97_RS12255	COG2084	Dehydrogenase
CP97_RS12260	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CP97_RS12265	COG0805	protein transport
CP97_RS12270	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP97_RS12275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP97_RS12280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CP97_RS12285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CP97_RS12300	COG0018	arginyl-trna synthetase
CP97_RS12310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CP97_RS12315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CP97_RS12320	COG0328	RNA-DNA hybrid ribonuclease activity
CP97_RS12345	COG4964	Belongs to the GSP D family
CP97_RS12375	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CP97_RS12395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP97_RS12405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP97_RS12410	COG0154	amidase activity
CP97_RS12415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP97_RS12425	COG0545	Peptidyl-prolyl cis-trans isomerase
CP97_RS12430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CP97_RS12435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP97_RS12440	COG0564	pseudouridine synthase activity
CP97_RS12470	COG1127	ABC transporter
CP97_RS12480	COG0525	valine-tRNA ligase activity
CP97_RS12500	COG0730	response to heat
CP97_RS12515	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP97_RS12535	COG0544	peptidyl-prolyl cis-trans isomerase activity
CP97_RS12550	COG0740	serine-type endopeptidase activity
CP97_RS12555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CP97_RS12580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP97_RS12585	COG0564	pseudouridine synthase activity
CP97_RS12600	COG3023	N-Acetylmuramoyl-L-alanine amidase
CP97_RS12605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CP97_RS12620	COG1160	GTP binding
CP97_RS12645	COG2030	dehydratase
CP97_RS12650	COG0045	succinate-CoA ligase (ADP-forming) activity
CP97_RS12650	COG1042	CoA-binding domain protein
CP97_RS12650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP97_RS12655	COG0183	Belongs to the thiolase family
CP97_RS12680	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS12685	COG1960	acyl-CoA dehydrogenase activity
CP97_RS12690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP97_RS12695	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CP97_RS12730	COG0408	coproporphyrinogen oxidase activity
CP97_RS12740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CP97_RS12745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP97_RS12755	COG0471	metal ion transport
CP97_RS12775	COG0484	heat shock protein binding
CP97_RS12780	COG2885	chlorophyll binding
CP97_RS12785	COG0823	Involved in the tonB-independent uptake of proteins
CP97_RS12805	COG0824	Thioesterase
CP97_RS12815	COG0140	phosphoribosyl-ATP diphosphatase activity
CP97_RS12825	COG0107	imidazoleglycerol-phosphate synthase activity
CP97_RS12830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CP97_RS12835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CP97_RS12840	COG0131	Imidazoleglycerol-phosphate dehydratase
CP97_RS12855	COG0194	GDP metabolic process
CP97_RS12860	COG2171	N-acyltransferase activity
CP97_RS12930	COG1278	Cold shock
CP97_RS12935	COG1671	Belongs to the UPF0178 family
CP97_RS12965	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CP97_RS12975	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CP97_RS12990	COG0823	Involved in the tonB-independent uptake of proteins
CP97_RS12990	COG4946	Tricorn protease homolog
CP97_RS12990	COG1506	peptidase
CP97_RS13025	COG4770	biotin carboxylase activity
CP97_RS13055	COG0783	Belongs to the Dps family
CP97_RS13070	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CP97_RS13075	COG0753	catalase activity
CP97_RS13100	COG2801	Transposase and inactivated derivatives
CP97_RS13155	COG0582	viral genome integration into host DNA
CP97_RS13180	COG1960	acyl-CoA dehydrogenase activity
CP97_RS13185	COG1024	Enoyl-CoA hydratase
CP97_RS13190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP97_RS13210	COG0488	(ABC) transporter
CP97_RS13235	COG2010	Cytochrome c
CP97_RS13270	COG0443	Heat shock 70 kDa protein
CP97_RS13320	COG5265	(ABC) transporter
CP97_RS13325	COG0659	secondary active sulfate transmembrane transporter activity
CP97_RS13330	COG2095	MarC family integral membrane protein
CP97_RS13335	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CP97_RS13345	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CP97_RS13365	COG0629	single-stranded DNA binding
CP97_RS13370	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CP97_RS13370	COG1918	ferrous iron import across plasma membrane
CP97_RS13390	COG1999	signal sequence binding
CP97_RS13395	COG2983	Belongs to the UPF0260 family
CP97_RS13410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP97_RS13410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP97_RS13430	COG1448	Aminotransferase
CP97_RS13445	COG0582	viral genome integration into host DNA
CP97_RS13465	COG2801	Transposase and inactivated derivatives
CP97_RS13505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP97_RS13510	COG3550	peptidyl-serine autophosphorylation
CP97_RS13515	COG1396	sequence-specific DNA binding
CP97_RS13525	COG3047	cAMP biosynthetic process
CP97_RS13530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CP97_RS13545	COG4771	TonB-dependent receptor
CP97_RS13550	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_RS13570	COG4638	Rieske (2fe-2S)
CP97_RS13575	COG1309	transcriptional regulator
CP97_RS13585	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS13595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP97_RS13600	COG0509	glycine decarboxylation via glycine cleavage system
CP97_RS13605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP97_RS13610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP97_RS13635	COG0741	lytic transglycosylase activity
CP97_RS13635	COG1196	nuclear chromosome segregation
CP97_RS13635	COG0739	heme binding
CP97_RS13650	COG3451	type IV secretory pathway VirB4
CP97_RS13655	COG3704	protein secretion by the type IV secretion system
CP97_RS13670	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CP97_RS13675	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CP97_RS13680	COG0248	Ppx GppA phosphatase
CP97_RS13705	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP97_RS13710	COG2072	flavoprotein involved in K transport
CP97_RS13715	COG1058	Belongs to the CinA family
CP97_RS13715	COG1546	Belongs to the CinA family
CP97_RS13720	COG0081	regulation of translation
CP97_RS13725	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CP97_RS13745	COG1115	amino acid carrier protein
CP97_RS13760	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CP97_RS13765	COG4765	Protein conserved in bacteria
CP97_RS13785	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_RS13820	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CP97_RS13820	COG0662	Cupin 2, conserved barrel domain protein
CP97_RS13845	COG0450	alkyl hydroperoxide reductase
CP97_RS13880	COG1294	oxidase, subunit
CP97_RS13885	COG1024	Enoyl-CoA hydratase
CP97_RS13895	COG2086	electron transfer activity
CP97_RS13900	COG4770	biotin carboxylase activity
CP97_RS13905	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP97_RS13905	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP97_RS13910	COG0346	lactoylglutathione lyase activity
CP97_RS13920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP97_RS13935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP97_RS13940	COG0243	molybdopterin cofactor binding
CP97_RS13945	COG2146	nitrite reductase [NAD(P)H] activity
CP97_RS13950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP97_RS13960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CP97_RS13960	COG1116	anion transmembrane transporter activity
CP97_RS13965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP97_RS13970	COG1116	anion transmembrane transporter activity
CP97_RS13970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CP97_RS13975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CP97_RS13980	COG0745	RESPONSE REGULATOR receiver
CP97_RS13990	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CP97_RS14000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP97_RS14010	COG0473	3-isopropylmalate dehydrogenase activity
CP97_RS14020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CP97_RS14025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP97_RS14040	COG2814	Major facilitator Superfamily
CP97_RS14050	COG3971	2-oxopent-4-enoate hydratase activity
CP97_RS14065	COG2271	Major facilitator Superfamily
CP97_RS14090	COG1012	belongs to the aldehyde dehydrogenase family
CP97_RS14115	COG4771	TonB-dependent receptor
CP97_RS14130	COG4638	Rieske (2fe-2S)
CP97_RS14135	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CP97_RS14145	COG0346	lactoylglutathione lyase activity
CP97_RS14150	COG4638	Rieske (2fe-2S)
CP97_RS14165	COG4638	Rieske (2fe-2S)
CP97_RS14170	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CP97_RS14200	COG3971	2-oxopent-4-enoate hydratase activity
CP97_RS14220	COG1942	4-Oxalocrotonate Tautomerase
CP97_RS14225	COG1012	belongs to the aldehyde dehydrogenase family
CP97_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS14260	COG2801	Transposase and inactivated derivatives
CP97_RS14275	COG4771	TonB-dependent receptor
CP97_RS14290	COG1566	PFAM secretion protein HlyD family protein
CP97_RS14310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP97_RS14315	COG0730	response to heat
CP97_RS14335	COG1414	Transcriptional regulator
CP97_RS14345	COG0842	Transport permease protein
CP97_RS14350	COG0842	Transport permease protein
CP97_RS14350	COG1129	ABC transporter
CP97_RS14355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP97_RS14365	COG0628	permease
CP97_RS14370	COG1063	alcohol dehydrogenase
CP97_RS14380	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP97_RS14380	COG0574	Belongs to the PEP-utilizing enzyme family
CP97_RS14385	COG3459	Glycosyltransferase 36 associated
CP97_RS14435	COG1137	ATPase activity
CP97_RS14450	COG4191	Histidine kinase
CP97_RS14455	COG4566	intracellular signal transduction
CP97_RS14475	COG2217	Heavy metal translocating P-type atpase
CP97_RS14485	COG0668	transmembrane transport
CP97_RS14490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP97_RS14495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CP97_RS14500	COG1127	ABC transporter
CP97_RS14525	COG0798	PFAM Bile acid sodium symporter
CP97_RS14555	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_RS14565	COG4638	Rieske (2fe-2S)
CP97_RS14570	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CP97_RS14575	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP97_RS14575	COG0596	Alpha beta hydrolase
CP97_RS14580	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_RS14585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP97_RS14590	COG1024	Enoyl-CoA hydratase
CP97_RS14605	COG4771	TonB-dependent receptor
CP97_RS14665	COG2202	Pas domain
CP97_RS14665	COG2205	protein histidine kinase activity
CP97_RS14695	COG1695	Transcriptional regulator
CP97_RS14700	COG0494	nUDIX hydrolase
CP97_RS14710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein