locus-tag	class	description
CCF18_RS00005	COG0037	tRNA processing
CCF18_RS00010	COG4568	rho-dependent transcription termination
CCF18_RS00020	COG4681	YaeQ
CCF18_RS00025	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CCF18_RS00030	COG3015	lipoprotein NlpE involved in copper resistance
CCF18_RS00040	COG1720	tRNA m6t6A37 methyltransferase activity
CCF18_RS00050	COG1464	Belongs to the NlpA lipoprotein family
CCF18_RS00055	COG2011	ABC-type metal ion transport system permease component
CCF18_RS00065	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CCF18_RS00100	COG0656	L-ascorbic acid biosynthetic process
CCF18_RS00105	COG0583	DNA-binding transcription factor activity
CCF18_RS00115	COG1388	LysM domain
CCF18_RS00115	COG0741	lytic transglycosylase activity
CCF18_RS00125	COG2226	methyltransferase
CCF18_RS00135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CCF18_RS00155	COG4104	PAAR repeat-containing protein
CCF18_RS00160	COG3157	Type VI secretion system effector, Hcp
CCF18_RS00250	COG3209	COG3209 Rhs family protein
CCF18_RS00270	COG3209	COG3209 Rhs family protein
CCF18_RS00300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CCF18_RS00310	COG1960	acyl-CoA dehydrogenase activity
CCF18_RS00320	COG0121	glutamine amidotransferase
CCF18_RS00325	COG3034	peptidoglycan biosynthetic process
CCF18_RS00330	COG0791	NLP P60 protein
CCF18_RS00355	COG1987	bacterial-type flagellum assembly
CCF18_RS00380	COG1677	Flagellar hook-basal body complex protein FliE
CCF18_RS00390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCF18_RS00410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CCF18_RS00475	COG1815	bacterial-type flagellum-dependent cell motility
CCF18_RS00480	COG1558	bacterial-type flagellum-dependent cell motility
CCF18_RS00490	COG1749	Flagellar hook protein flgE
CCF18_RS00495	COG4787	bacterial-type flagellum-dependent cell motility
CCF18_RS00520	COG4786	Flagellar basal body rod
CCF18_RS00520	COG1256	bacterial-type flagellum assembly
CCF18_RS00525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCF18_RS00540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCF18_RS00550	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CCF18_RS00575	COG1191	sigma factor activity
CCF18_RS00580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CCF18_RS00595	COG0454	-acetyltransferase
CCF18_RS00600	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CCF18_RS00605	COG2195	Cleaves the N-terminal amino acid of tripeptides
CCF18_RS00625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CCF18_RS00645	COG0582	viral genome integration into host DNA
CCF18_RS00710	COG2161	toxin-antitoxin pair type II binding
CCF18_RS00770	COG3059	membrane
CCF18_RS00780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCF18_RS00785	COG2207	Transcriptional regulator
CCF18_RS00790	COG1620	l-lactate permease
CCF18_RS00795	COG0247	lactate metabolic process
CCF18_RS00800	COG1139	Iron-sulfur cluster binding protein
CCF18_RS00805	COG1556	Lactate utilization protein
CCF18_RS00815	COG0667	Aldo Keto reductase
CCF18_RS00825	COG2200	EAL domain
CCF18_RS00825	COG2771	luxR family
CCF18_RS00830	COG0583	DNA-binding transcription factor activity
CCF18_RS00840	COG0666	response to abiotic stimulus
CCF18_RS00850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CCF18_RS00855	COG1304	FMN binding
CCF18_RS00860	COG0549	Belongs to the carbamate kinase family
CCF18_RS00865	COG0402	S-adenosylhomocysteine deaminase activity
CCF18_RS00870	COG1280	lysine exporter protein (LysE YggA)
CCF18_RS00885	COG3829	transcription factor binding
CCF18_RS00890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CCF18_RS00895	COG0372	Belongs to the citrate synthase family
CCF18_RS00900	COG2079	MmgE PrpD family protein
CCF18_RS00905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CCF18_RS00915	COG3122	Protein conserved in bacteria
CCF18_RS00935	COG4521	taurine ABC transporter
CCF18_RS00945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CCF18_RS00950	COG2175	clavaminate synthase activity
CCF18_RS00955	COG0113	porphobilinogen synthase activity
CCF18_RS00960	COG3468	outer membrane autotransporter barrel domain protein
CCF18_RS00965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCF18_RS00970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CCF18_RS00975	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CCF18_RS00995	COG1181	Belongs to the D-alanine--D-alanine ligase family
CCF18_RS01005	COG1785	Belongs to the alkaline phosphatase family
CCF18_RS01015	COG3706	GGDEF domain
CCF18_RS01020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CCF18_RS01035	COG4126	flavin adenine dinucleotide binding
CCF18_RS01055	COG1940	carbohydrate kinase activity
CCF18_RS01060	COG0419	ATPase involved in DNA repair
CCF18_RS01065	COG0420	3'-5' exonuclease activity
CCF18_RS01070	COG0745	RESPONSE REGULATOR receiver
CCF18_RS01075	COG5002	protein histidine kinase activity
CCF18_RS01080	COG1114	Component of the transport system for branched-chain amino acids
CCF18_RS01085	COG1113	amino acid transport
CCF18_RS01090	COG0366	Alpha amylase catalytic
CCF18_RS01110	COG1862	Preprotein translocase
CCF18_RS01115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCF18_RS01120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCF18_RS01125	COG1403	HNH endonuclease
CCF18_RS01130	COG3248	Nucleoside-binding outer membrane protein
CCF18_RS01135	COG4238	major outer membrane lipoprotein
CCF18_RS01145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CCF18_RS01145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CCF18_RS01160	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CCF18_RS01165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CCF18_RS01175	COG0667	Aldo Keto reductase
CCF18_RS01185	COG0142	geranyltranstransferase activity
CCF18_RS01200	COG0693	protein deglycase activity
CCF18_RS01205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CCF18_RS01215	COG2814	Major facilitator Superfamily
CCF18_RS01235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CCF18_RS01240	COG1845	cytochrome c oxidase, subunit III
CCF18_RS01245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CCF18_RS01250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CCF18_RS01255	COG2223	nitrite transmembrane transporter activity
CCF18_RS01260	COG3056	Lipoprotein
CCF18_RS01265	COG0271	Belongs to the BolA IbaG family
CCF18_RS01285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CCF18_RS01290	COG0776	regulation of translation
CCF18_RS01295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCF18_RS01300	COG1555	photosystem II stabilization
CCF18_RS01305	COG0824	Thioesterase
CCF18_RS01315	COG4533	DNA binding
CCF18_RS01325	COG1522	sequence-specific DNA binding
CCF18_RS01330	COG1132	(ABC) transporter
CCF18_RS01340	COG0347	Belongs to the P(II) protein family
CCF18_RS01345	COG0004	ammonium transporteR
CCF18_RS01350	COG1946	Acyl-CoA thioesterase
CCF18_RS01355	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CCF18_RS01360	COG3695	enzyme binding
CCF18_RS01370	COG5507	3-demethylubiquinone-9 3-methyltransferase
CCF18_RS01375	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CCF18_RS01385	COG0110	maltose O-acetyltransferase activity
CCF18_RS01400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCF18_RS01405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCF18_RS01410	COG1309	transcriptional regulator
CCF18_RS01415	COG3264	Mechanosensitive ion channel
CCF18_RS01415	COG1196	nuclear chromosome segregation
CCF18_RS01425	COG3923	Primosomal replication protein n
CCF18_RS01430	COG2832	Protein of unknown function (DUF454)
CCF18_RS01440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CCF18_RS01475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCF18_RS01490	COG4651	solute:proton antiporter activity
CCF18_RS01490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CCF18_RS01495	COG2223	nitrite transmembrane transporter activity
CCF18_RS01500	COG0737	Belongs to the 5'-nucleotidase family
CCF18_RS01505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CCF18_RS01510	COG3735	TraB family
CCF18_RS01515	COG2217	Heavy metal translocating P-type atpase
CCF18_RS01525	COG0531	amino acid
CCF18_RS01530	COG0789	Transcriptional regulator
CCF18_RS01540	COG1585	Membrane protein implicated in regulation of membrane protease activity
CCF18_RS01545	COG0330	HflC and HflK could
CCF18_RS01550	COG4619	ABC transporter
CCF18_RS01555	COG0390	transport system, permease component
CCF18_RS01560	COG3118	belongs to the thioredoxin family
CCF18_RS01565	COG0300	oxidoreductase activity
CCF18_RS01570	COG2755	lipolytic protein G-D-S-L family
CCF18_RS01575	COG4181	ATPase activity
CCF18_RS01580	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CCF18_RS01590	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CCF18_RS01595	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CCF18_RS01610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CCF18_RS01620	COG1988	membrane-bound metal-dependent
CCF18_RS01625	COG2501	S4 domain
CCF18_RS01635	COG3539	Fimbrial protein
CCF18_RS01640	COG3121	Chaperone
CCF18_RS01645	COG3188	usher protein
CCF18_RS01650	COG3539	Fimbrial protein
CCF18_RS01655	COG3539	Fimbrial protein
CCF18_RS01660	COG2197	response regulator
CCF18_RS01675	COG2207	Transcriptional regulator
CCF18_RS01685	COG4783	chaperone-mediated protein folding
CCF18_RS01690	COG1215	transferase activity, transferring glycosyl groups
CCF18_RS01705	COG3210	domain, Protein
CCF18_RS01730	COG5002	protein histidine kinase activity
CCF18_RS01735	COG0745	RESPONSE REGULATOR receiver
CCF18_RS01740	COG1538	Outer membrane efflux protein
CCF18_RS01745	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCF18_RS01750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCF18_RS01755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCF18_RS01760	COG1113	amino acid transport
CCF18_RS01765	COG0668	transmembrane transport
CCF18_RS01770	COG0778	Nitroreductase
CCF18_RS01775	COG2315	Protein conserved in bacteria
CCF18_RS01800	COG2977	Belongs to the P-Pant transferase superfamily
CCF18_RS01805	COG4771	TonB-dependent receptor
CCF18_RS01810	COG2382	esterase
CCF18_RS01815	COG3251	PFAM MbtH domain protein
CCF18_RS01820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CCF18_RS01820	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
CCF18_RS01825	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CCF18_RS01830	COG1120	ATPase activity
CCF18_RS01835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCF18_RS01840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCF18_RS01850	COG4592	Periplasmic binding protein
CCF18_RS01855	COG1169	isochorismate synthase
CCF18_RS01860	COG1021	2,3-dihydroxybenzoate-AMP ligase
CCF18_RS01865	COG1535	isochorismatase
CCF18_RS01865	COG3433	isochorismatase activity
CCF18_RS01870	COG1028	Short-chain dehydrogenase reductase Sdr
CCF18_RS01880	COG1966	Carbon starvation protein
CCF18_RS01885	COG2879	small protein
CCF18_RS01890	COG0371	Dehydrogenase
CCF18_RS01895	COG0436	Aminotransferase
CCF18_RS01900	COG1475	DNA binding
CCF18_RS01905	COG3969	phosphoadenosine phosphosulfate
CCF18_RS01910	COG0583	DNA-binding transcription factor activity
CCF18_RS01915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CCF18_RS01920	COG0450	alkyl hydroperoxide reductase
CCF18_RS01925	COG3634	alkyl hydroperoxide reductase activity
CCF18_RS01930	COG0589	response to stress
CCF18_RS01935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CCF18_RS01940	COG3719	Belongs to the RNase T2 family
CCF18_RS01945	COG0471	metal ion transport
CCF18_RS01960	COG3051	citrate lyase alpha subunit
CCF18_RS01965	COG2301	Belongs to the HpcH HpaI aldolase family
CCF18_RS01975	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CCF18_RS01980	COG3290	protein histidine kinase activity
CCF18_RS01985	COG4565	transcriptional regulatory protein
CCF18_RS01990	COG3069	C4-dicarboxylate transmembrane transporter activity
CCF18_RS02010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CCF18_RS02015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CCF18_RS02025	COG0583	DNA-binding transcription factor activity
CCF18_RS02040	COG1686	Belongs to the peptidase S11 family
CCF18_RS02045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CCF18_RS02050	COG0772	Belongs to the SEDS family
CCF18_RS02055	COG0768	penicillin binding
CCF18_RS02065	COG0799	negative regulation of ribosome biogenesis
CCF18_RS02070	COG0406	alpha-ribazole phosphatase activity
CCF18_RS02080	COG1466	dna polymerase III delta subunit
CCF18_RS02095	COG1609	Transcriptional regulator
CCF18_RS02120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS02120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCF18_RS02120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCF18_RS02130	COG2888	peptidyl-tyrosine sulfation
CCF18_RS02140	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CCF18_RS02150	COG2214	Heat shock protein DnaJ domain protein
CCF18_RS02155	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CCF18_RS02165	COG2214	Heat shock protein DnaJ domain protein
CCF18_RS02170	COG0443	Heat shock 70 kDa protein
CCF18_RS02180	COG1126	abc transporter atp-binding protein
CCF18_RS02185	COG0765	amino acid transport
CCF18_RS02190	COG0765	amino acid transport
CCF18_RS02195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCF18_RS02205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CCF18_RS02210	COG4535	Mg2 and Co2 transporter CorC
CCF18_RS02220	COG1702	phosphate starvation-inducible protein PhoH
CCF18_RS02230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCF18_RS02275	COG0367	asparagine synthase
CCF18_RS02280	COG0647	UMP catabolic process
CCF18_RS02285	COG1846	Transcriptional regulator
CCF18_RS02285	COG1940	carbohydrate kinase activity
CCF18_RS02290	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CCF18_RS02300	COG1263	PTS System
CCF18_RS02300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCF18_RS02300	COG2190	(PTS) system
CCF18_RS02320	COG0735	belongs to the Fur family
CCF18_RS02330	COG0716	FMN binding
CCF18_RS02340	COG0596	Alpha beta hydrolase
CCF18_RS02345	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CCF18_RS02350	COG0033	Phosphoglucomutase
CCF18_RS02355	COG0531	amino acid
CCF18_RS02360	COG1982	Orn Lys Arg decarboxylase major
CCF18_RS02375	COG0745	RESPONSE REGULATOR receiver
CCF18_RS02380	COG2205	protein histidine kinase activity
CCF18_RS02410	COG3209	COG3209 Rhs family protein
CCF18_RS02425	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CCF18_RS02450	COG3272	Protein of unknown function (DUF1722)
CCF18_RS02455	COG0415	Belongs to the DNA photolyase family
CCF18_RS02465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CCF18_RS02470	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CCF18_RS02475	COG1984	allophanate hydrolase subunit 2
CCF18_RS02495	COG3539	Fimbrial protein
CCF18_RS02500	COG3121	Chaperone
CCF18_RS02505	COG3188	usher protein
CCF18_RS02510	COG3539	Fimbrial protein
CCF18_RS02515	COG2186	Transcriptional regulator
CCF18_RS02520	COG0473	3-isopropylmalate dehydrogenase activity
CCF18_RS02520	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CCF18_RS02525	COG1063	alcohol dehydrogenase
CCF18_RS02530	COG1028	Short-chain dehydrogenase reductase Sdr
CCF18_RS02540	COG2721	sulfolactate sulfo-lyase activity
CCF18_RS02545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CCF18_RS02555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CCF18_RS02560	COG0372	Belongs to the citrate synthase family
CCF18_RS02570	COG2009	succinate dehydrogenase
CCF18_RS02575	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CCF18_RS02580	COG1053	succinate dehydrogenase
CCF18_RS02585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CCF18_RS02590	COG0567	Dehydrogenase, E1 component
CCF18_RS02595	COG0508	dehydrogenase complex catalyzes the overall conversion of
CCF18_RS02605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CCF18_RS02620	COG1271	oxidase subunit
CCF18_RS02625	COG1294	oxidase, subunit
CCF18_RS02630	COG4890	Cyd operon protein YbgT
CCF18_RS02635	COG3790	cyd operon protein YbgE
CCF18_RS02640	COG0824	Thioesterase
CCF18_RS02645	COG0811	peptide transport
CCF18_RS02650	COG0848	biopolymer transport protein
CCF18_RS02655	COG3064	Membrane
CCF18_RS02665	COG2885	chlorophyll binding
CCF18_RS02670	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CCF18_RS02715	COG3201	nicotinamide mononucleotide transporter
CCF18_RS02720	COG1230	cation diffusion facilitator family transporter
CCF18_RS02725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCF18_RS02735	COG2017	converts alpha-aldose to the beta-anomer
CCF18_RS02745	COG1085	galactose-1-phosphate uridylyltransferase
CCF18_RS02750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CCF18_RS02755	COG1119	ATPase activity
CCF18_RS02760	COG3585	molybdate ion transport
CCF18_RS02760	COG2005	Transcriptional regulator
CCF18_RS02770	COG0725	ABC transporter, periplasmic molybdate-binding protein
CCF18_RS02775	COG4149	molybdate abc transporter
CCF18_RS02785	COG0561	phosphatase activity
CCF18_RS02795	COG0583	DNA-binding transcription factor activity
CCF18_RS02800	COG2828	Protein conserved in bacteria
CCF18_RS02805	COG0471	metal ion transport
CCF18_RS02810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CCF18_RS02815	COG4677	pectinesterase activity
CCF18_RS02825	COG2267	carboxylic ester hydrolase activity
CCF18_RS02845	COG1881	PFAM PEBP family protein
CCF18_RS02850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CCF18_RS02865	COG2226	methyltransferase
CCF18_RS02870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CCF18_RS02880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CCF18_RS02890	COG0521	Mo-molybdopterin cofactor biosynthetic process
CCF18_RS02900	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CCF18_RS02905	COG0314	molybdopterin synthase activity
CCF18_RS02910	COG0670	Belongs to the BI1 family
CCF18_RS02935	COG0842	Transport permease protein
CCF18_RS02940	COG0842	Transport permease protein
CCF18_RS02945	COG1131	(ABC) transporter
CCF18_RS02955	COG1309	transcriptional regulator
CCF18_RS02960	COG0513	Belongs to the DEAD box helicase family
CCF18_RS02970	COG1199	ATP-dependent helicase activity
CCF18_RS02975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CCF18_RS02980	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CCF18_RS02990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CCF18_RS03005	COG1126	abc transporter atp-binding protein
CCF18_RS03010	COG0765	amino acid transport
CCF18_RS03015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCF18_RS03025	COG5006	permease, DMT superfamily
CCF18_RS03035	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CCF18_RS03040	COG2194	sulfuric ester hydrolase activity
CCF18_RS03050	COG1321	iron dependent repressor
CCF18_RS03055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CCF18_RS03060	COG1376	ErfK ybiS ycfS ynhG family protein
CCF18_RS03065	COG0488	(ABC) transporter
CCF18_RS03070	COG0561	phosphatase activity
CCF18_RS03075	COG1882	Formate acetyltransferase
CCF18_RS03080	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CCF18_RS03085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CCF18_RS03090	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CCF18_RS03095	COG0303	'Molybdopterin
CCF18_RS03100	COG1446	asparaginase
CCF18_RS03110	COG0747	negative chemotaxis
CCF18_RS03125	COG2200	EAL domain
CCF18_RS03135	COG1413	lyase activity
CCF18_RS03150	COG0625	glutathione transferase activity
CCF18_RS03155	COG1686	Belongs to the peptidase S11 family
CCF18_RS03160	COG1349	DNA-binding transcription factor activity
CCF18_RS03165	COG0671	phosphoesterase, PA-phosphatase related
CCF18_RS03170	COG2814	Major facilitator Superfamily
CCF18_RS03180	COG0561	phosphatase activity
CCF18_RS03185	COG0738	Major facilitator superfamily
CCF18_RS03190	COG3226	Transcriptional regulator
CCF18_RS03205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CCF18_RS03215	COG0778	Nitroreductase
CCF18_RS03230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CCF18_RS03235	COG3842	ATPase activity
CCF18_RS03240	COG1176	ABC-type spermidine putrescine transport system, permease component I
CCF18_RS03245	COG1177	transmembrane transport
CCF18_RS03260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCF18_RS03265	COG4160	amino acid transport
CCF18_RS03270	COG4215	(ABC) transporter
CCF18_RS03275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCF18_RS03280	COG1126	abc transporter atp-binding protein
CCF18_RS03295	COG3023	N-Acetylmuramoyl-L-alanine amidase
CCF18_RS03300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CCF18_RS03305	COG0702	epimerase
CCF18_RS03310	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CCF18_RS03315	COG0028	Belongs to the TPP enzyme family
CCF18_RS03320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CCF18_RS03330	COG2431	L-lysine efflux transmembrane transporter activity
CCF18_RS03340	COG3593	DNA synthesis involved in DNA repair
CCF18_RS03345	COG2990	Protein conserved in bacteria
CCF18_RS03350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCF18_RS03360	COG1278	Cold shock
CCF18_RS03370	COG0542	response to heat
CCF18_RS03375	COG1518	maintenance of DNA repeat elements
CCF18_RS03380	COG1203	CRISPR-associated helicase, Cas3
CCF18_RS03410	COG3539	Fimbrial protein
CCF18_RS03415	COG3121	Chaperone
CCF18_RS03420	COG3188	usher protein
CCF18_RS03450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CCF18_RS03455	COG4988	ABC transporter
CCF18_RS03460	COG0492	ferredoxin-NADP+ reductase activity
CCF18_RS03465	COG1522	sequence-specific DNA binding
CCF18_RS03470	COG1178	ABC-type Fe3 transport system permease component
CCF18_RS03470	COG1674	ftsk spoiiie
CCF18_RS03480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CCF18_RS03490	COG0243	molybdopterin cofactor binding
CCF18_RS03495	COG0437	4 iron, 4 sulfur cluster binding
CCF18_RS03500	COG3302	dmso reductase anchor subunit
CCF18_RS03505	COG1335	isochorismatase
CCF18_RS03515	COG0531	amino acid
CCF18_RS03520	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CCF18_RS03525	COG4974	Belongs to the 'phage' integrase family
CCF18_RS03580	COG4695	Portal protein
CCF18_RS03680	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CCF18_RS03690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CCF18_RS03735	COG1882	Formate acetyltransferase
CCF18_RS03740	COG2116	formate transmembrane transporter activity
CCF18_RS03745	COG1944	ATP diphosphatase activity
CCF18_RS03765	COG0539	negative regulation of cytoplasmic translation
CCF18_RS03775	COG0658	competence protein
CCF18_RS03775	COG2333	competence protein COMEC
CCF18_RS03790	COG3214	Protein conserved in bacteria
CCF18_RS03805	COG3173	Aminoglycoside phosphotransferase
CCF18_RS03810	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CCF18_RS03815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CCF18_RS03825	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CCF18_RS03835	COG2989	Protein conserved in bacteria
CCF18_RS03840	COG3108	Peptidase M15
CCF18_RS03845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CCF18_RS03850	COG1448	Aminotransferase
CCF18_RS03870	COG0308	aminopeptidase N
CCF18_RS03885	COG0633	Ferredoxin
CCF18_RS03885	COG3217	Mosc domain protein beta barrel domain protein
CCF18_RS03895	COG0488	(ABC) transporter
CCF18_RS03900	COG2995	paraquat-inducible protein a
CCF18_RS03905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CCF18_RS03905	COG3008	intermembrane lipid transfer
CCF18_RS03910	COG3009	Protein conserved in bacteria
CCF18_RS03915	COG3130	regulation of translation
CCF18_RS03925	COG1067	ATP-dependent peptidase activity
CCF18_RS03945	COG3070	regulator of competence-specific genes
CCF18_RS03950	COG1289	transmembrane transporter activity
CCF18_RS03955	COG3304	Inner membrane component domain
CCF18_RS03960	COG0210	DNA helicase
CCF18_RS03975	COG1832	CoA-binding protein
CCF18_RS03990	COG1254	Belongs to the acylphosphatase family
CCF18_RS03995	COG2920	part of a sulfur-relay system
CCF18_RS04000	COG0670	Belongs to the BI1 family
CCF18_RS04015	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CCF18_RS04020	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CCF18_RS04025	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CCF18_RS04030	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CCF18_RS04035	COG1999	signal sequence binding
CCF18_RS04040	COG1773	rubredoxin
CCF18_RS04045	COG1271	oxidase subunit
CCF18_RS04050	COG1294	oxidase, subunit
CCF18_RS04065	COG0489	protein tyrosine kinase activity
CCF18_RS04065	COG3206	protein involved in exopolysaccharide biosynthesis
CCF18_RS04070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CCF18_RS04075	COG1596	polysaccharide export
CCF18_RS04080	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCF18_RS04100	COG1278	Cold shock
CCF18_RS04105	COG1278	Cold shock
CCF18_RS04125	COG0348	domain, Protein
CCF18_RS04130	COG2205	protein histidine kinase activity
CCF18_RS04130	COG2198	Histidine kinase
CCF18_RS04130	COG0784	Response regulator, receiver
CCF18_RS04135	COG1879	ABC-type sugar transport system periplasmic component
CCF18_RS04140	COG0745	RESPONSE REGULATOR receiver
CCF18_RS04145	COG3005	denitrification pathway
CCF18_RS04150	COG0243	molybdopterin cofactor binding
CCF18_RS04155	COG3381	protein complex oligomerization
CCF18_RS04190	COG3729	General stress protein
CCF18_RS04195	COG1309	transcriptional regulator
CCF18_RS04200	COG0506	proline dehydrogenase activity
CCF18_RS04200	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CCF18_RS04200	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CCF18_RS04210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CCF18_RS04230	COG1702	phosphate starvation-inducible protein PhoH
CCF18_RS04240	COG2831	hemolysin activation secretion protein
CCF18_RS04245	COG2994	toxin metabolic process
CCF18_RS04250	COG3210	domain, Protein
CCF18_RS04285	COG3381	protein complex oligomerization
CCF18_RS04295	COG1462	curli production assembly transport component CsgG
CCF18_RS04310	COG2197	response regulator
CCF18_RS04335	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CCF18_RS04340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CCF18_RS04355	COG2943	transferase activity, transferring hexosyl groups
CCF18_RS04360	COG5645	(Lipo)protein
CCF18_RS04375	COG1560	Kdo2-lipid A biosynthetic process
CCF18_RS04420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCF18_RS04430	COG0673	inositol 2-dehydrogenase activity
CCF18_RS04435	COG0728	peptidoglycan biosynthetic process
CCF18_RS04440	COG3418	PFAM FlgN family protein
CCF18_RS04445	COG2747	anti-sigma28 factor FlgM
CCF18_RS04450	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
CCF18_RS04455	COG1815	bacterial-type flagellum-dependent cell motility
CCF18_RS04460	COG1558	bacterial-type flagellum-dependent cell motility
CCF18_RS04465	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CCF18_RS04470	COG1749	Flagellar hook protein flgE
CCF18_RS04475	COG4787	bacterial-type flagellum-dependent cell motility
CCF18_RS04480	COG4786	Flagellar basal body rod
CCF18_RS04490	COG1706	bacterial-type flagellum-dependent cell motility
CCF18_RS04495	COG1705	Flagellar rod assembly protein muramidase FlgJ
CCF18_RS04495	COG3951	Flagellar rod assembly protein muramidase FlgJ
CCF18_RS04500	COG1256	bacterial-type flagellum assembly
CCF18_RS04505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCF18_RS04510	COG1530	ribonuclease E activity
CCF18_RS04520	COG0564	pseudouridine synthase activity
CCF18_RS04525	COG0424	maF-like protein
CCF18_RS04530	COG1399	metal-binding, possibly nucleic acid-binding protein
CCF18_RS04550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CCF18_RS04555	COG1028	Short-chain dehydrogenase reductase Sdr
CCF18_RS04565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CCF18_RS04570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CCF18_RS04575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CCF18_RS04585	COG0470	DNA polymerase III
CCF18_RS04590	COG0084	hydrolase, TatD family'
CCF18_RS04595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCF18_RS04595	COG1263	PTS System
CCF18_RS04605	COG0537	adenosine 5'-monophosphoramidase activity
CCF18_RS04610	COG5633	Lipoprotein
CCF18_RS04615	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
CCF18_RS04635	COG1252	NADH dehydrogenase
CCF18_RS04640	COG3134	Outer membrane lipoprotein
CCF18_RS04645	COG1309	transcriptional regulator
CCF18_RS04655	COG1376	ErfK ybiS ycfS ynhG family protein
CCF18_RS04655	COG1388	LysM domain
CCF18_RS04660	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CCF18_RS04665	COG4591	ABC-type transport system involved in lipoprotein release permease component
CCF18_RS04675	COG4591	ABC-type transport system involved in lipoprotein release permease component
CCF18_RS04685	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CCF18_RS04690	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CCF18_RS04700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CCF18_RS04705	COG1177	transmembrane transport
CCF18_RS04715	COG3842	ATPase activity
CCF18_RS04725	COG2850	peptidyl-arginine hydroxylation
CCF18_RS04730	COG2205	protein histidine kinase activity
CCF18_RS04740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CCF18_RS04760	COG1187	pseudouridine synthase activity
CCF18_RS04765	COG0538	isocitrate dehydrogenase activity
CCF18_RS04775	COG0582	viral genome integration into host DNA
CCF18_RS04785	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CCF18_RS04790	COG5532	Uncharacterized conserved protein (DUF2303)
CCF18_RS04820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CCF18_RS04845	COG1846	Transcriptional regulator
CCF18_RS04855	COG4725	Belongs to the MT-A70-like family
CCF18_RS04865	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CCF18_RS04875	COG1403	HNH endonuclease
CCF18_RS04935	COG1802	Transcriptional regulator
CCF18_RS04935	COG4626	Terminase
CCF18_RS04945	COG4695	Portal protein
CCF18_RS04990	COG4386	tail sheath protein
CCF18_RS05015	COG4228	DNA circulation
CCF18_RS05035	COG3299	homolog of phage Mu protein gp47
CCF18_RS05040	COG3778	Protein conserved in bacteria
CCF18_RS05050	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CCF18_RS05065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CCF18_RS05070	COG1403	HNH endonuclease
CCF18_RS05075	COG0538	isocitrate dehydrogenase activity
CCF18_RS05080	COG1073	alpha beta
CCF18_RS05085	COG0583	DNA-binding transcription factor activity
CCF18_RS05120	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CCF18_RS05125	COG4571	Outer membrane protease
CCF18_RS05155	COG3468	outer membrane autotransporter barrel domain protein
CCF18_RS05155	COG3468	outer membrane autotransporter barrel domain protein
CCF18_RS05165	COG2894	cell division
CCF18_RS05180	COG0179	Fumarylacetoacetate (FAA) hydrolase
CCF18_RS05205	COG3477	response to acidic pH
CCF18_RS05210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CCF18_RS05225	COG2719	SpoVR family
CCF18_RS05235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CCF18_RS05245	COG1619	proteins homologs of microcin C7 resistance protein MccF
CCF18_RS05255	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CCF18_RS05270	COG0157	Belongs to the NadC ModD family
CCF18_RS05275	COG0500	methyltransferase
CCF18_RS05280	COG1120	ATPase activity
CCF18_RS05285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCF18_RS05320	COG2842	Transposition protein
CCF18_RS05445	COG4383	Mu-like prophage protein gp29
CCF18_RS05450	COG2369	cell adhesion
CCF18_RS05470	COG4397	Mu-like prophage major head subunit gpT
CCF18_RS05555	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CCF18_RS05570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCF18_RS05570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS05570	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CCF18_RS05575	COG1461	Dihydroxyacetone kinase
CCF18_RS05580	COG2376	Dihydroxyacetone kinase
CCF18_RS05585	COG3284	Transcriptional regulator
CCF18_RS05590	COG0012	GTP binding
CCF18_RS05605	COG0659	secondary active sulfate transmembrane transporter activity
CCF18_RS05610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CCF18_RS05635	COG2890	protein-(glutamine-N5) methyltransferase activity
CCF18_RS05640	COG3094	Invasion gene expression up-regulator, SirB
CCF18_RS05645	COG2912	Transglutaminase-like superfamily
CCF18_RS05660	COG0737	Belongs to the 5'-nucleotidase family
CCF18_RS05665	COG0737	Belongs to the 5'-nucleotidase family
CCF18_RS05665	COG1525	nuclease
CCF18_RS05665	COG4085	toxin activity
CCF18_RS05670	COG0737	Belongs to the 5'-nucleotidase family
CCF18_RS05680	COG0737	Belongs to the 5'-nucleotidase family
CCF18_RS05690	COG0387	Pfam Sodium calcium exchanger
CCF18_RS05700	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CCF18_RS05705	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CCF18_RS05710	COG2197	response regulator
CCF18_RS05715	COG3850	Histidine kinase
CCF18_RS05720	COG2223	nitrite transmembrane transporter activity
CCF18_RS05725	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CCF18_RS05730	COG1140	nitrate reductase beta subunit
CCF18_RS05735	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CCF18_RS05740	COG2181	nitrate reductase activity
CCF18_RS05745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CCF18_RS05750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CCF18_RS05795	COG0788	formyltetrahydrofolate deformylase activity
CCF18_RS05805	COG1752	Esterase of the alpha-beta hydrolase superfamily
CCF18_RS05810	COG0745	RESPONSE REGULATOR receiver
CCF18_RS05815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CCF18_RS05825	COG1435	thymidine kinase activity
CCF18_RS05830	COG1454	alcohol dehydrogenase
CCF18_RS05830	COG1012	belongs to the aldehyde dehydrogenase family
CCF18_RS05835	COG2095	MarC family integral membrane protein
CCF18_RS05840	COG4166	transmembrane transport
CCF18_RS05845	COG0601	transmembrane transport
CCF18_RS05850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCF18_RS05855	COG0444	Belongs to the ABC transporter superfamily
CCF18_RS05860	COG4608	Belongs to the ABC transporter superfamily
CCF18_RS05865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCF18_RS05890	COG2350	Protein conserved in bacteria
CCF18_RS05895	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CCF18_RS05905	COG1607	acyl-coa hydrolase
CCF18_RS05920	COG0727	PFAM Uncharacterised protein family (UPF0153)
CCF18_RS05925	COG3047	cAMP biosynthetic process
CCF18_RS05940	COG0135	phosphoribosylanthranilate isomerase activity
CCF18_RS05940	COG0134	indole-3-glycerol-phosphate synthase activity
CCF18_RS05945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CCF18_RS05945	COG0512	Glutamine amidotransferase of anthranilate synthase
CCF18_RS05950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CCF18_RS05960	COG0613	PHP domain protein
CCF18_RS05965	COG0009	L-threonylcarbamoyladenylate synthase
CCF18_RS05970	COG1187	pseudouridine synthase activity
CCF18_RS05985	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CCF18_RS05990	COG1028	Short-chain dehydrogenase reductase Sdr
CCF18_RS05995	COG0616	signal peptide processing
CCF18_RS06005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CCF18_RS06010	COG0583	DNA-binding transcription factor activity
CCF18_RS06020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CCF18_RS06030	COG0671	phosphoesterase, PA-phosphatase related
CCF18_RS06035	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CCF18_RS06040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CCF18_RS06050	COG0023	Translation Initiation Factor
CCF18_RS06060	COG1349	DNA-binding transcription factor activity
CCF18_RS06070	COG5001	Diguanylate cyclase
CCF18_RS06085	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CCF18_RS06085	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CCF18_RS06090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CCF18_RS06100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCF18_RS06115	COG2814	Major facilitator Superfamily
CCF18_RS06125	COG4172	Belongs to the ABC transporter superfamily
CCF18_RS06130	COG4171	peptide transport system, permease
CCF18_RS06140	COG2076	Multidrug Resistance protein
CCF18_RS06145	COG1881	PFAM PEBP family protein
CCF18_RS06150	COG2207	Transcriptional regulator
CCF18_RS06155	COG1902	pentaerythritol trinitrate reductase activity
CCF18_RS06160	COG1073	alpha beta
CCF18_RS06165	COG0583	DNA-binding transcription factor activity
CCF18_RS06170	COG4168	peptide transport system, permease
CCF18_RS06175	COG4166	transmembrane transport
CCF18_RS06185	COG0531	amino acid
CCF18_RS06195	COG0174	glutamine synthetase
CCF18_RS06200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CCF18_RS06205	COG1917	Cupin 2, conserved barrel domain protein
CCF18_RS06205	COG1396	sequence-specific DNA binding
CCF18_RS06210	COG1012	belongs to the aldehyde dehydrogenase family
CCF18_RS06215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CCF18_RS06220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CCF18_RS06225	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CCF18_RS06230	COG1842	Phage shock protein A
CCF18_RS06240	COG1983	PspC domain protein
CCF18_RS06250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCF18_RS06255	COG3106	COG3106 Predicted ATPase
CCF18_RS06265	COG3283	Transcriptional regulator of aromatic amino acids metabolism
CCF18_RS06270	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CCF18_RS06275	COG4948	Mandelate Racemase Muconate Lactonizing
CCF18_RS06280	COG2866	Carboxypeptidase
CCF18_RS06285	COG4166	transmembrane transport
CCF18_RS06290	COG0668	transmembrane transport
CCF18_RS06295	COG3182	Iron-regulated membrane protein
CCF18_RS06300	COG0589	response to stress
CCF18_RS06305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCF18_RS06310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CCF18_RS06320	COG2840	Smr protein MutS2
CCF18_RS06325	COG3706	GGDEF domain
CCF18_RS06340	COG0513	Belongs to the DEAD box helicase family
CCF18_RS06370	COG0589	response to stress
CCF18_RS06375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CCF18_RS06380	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCF18_RS06380	COG1013	pyruvate-flavodoxin oxidoreductase activity
CCF18_RS06380	COG0674	pyruvate-flavodoxin oxidoreductase activity
CCF18_RS06380	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CCF18_RS06385	COG3042	response to heat
CCF18_RS06390	COG3187	Heat shock protein
CCF18_RS06395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CCF18_RS06400	COG2911	Protein conserved in bacteria
CCF18_RS06410	COG3784	Protein of unknown function (DUF1318)
CCF18_RS06420	COG0667	Aldo Keto reductase
CCF18_RS06435	COG1643	Atp-dependent helicase
CCF18_RS06455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CCF18_RS06460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CCF18_RS06465	COG3038	cytochrome b561
CCF18_RS06470	COG0583	DNA-binding transcription factor activity
CCF18_RS06475	COG5383	Protein conserved in bacteria
CCF18_RS06485	COG2841	Protein conserved in bacteria
CCF18_RS06490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCF18_RS06495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CCF18_RS06500	COG1275	C4-dicarboxylate transporter malic acid transport protein
CCF18_RS06505	COG0500	methyltransferase
CCF18_RS06515	COG0826	peptidase U32
CCF18_RS06525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CCF18_RS06530	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CCF18_RS06535	COG3842	ATPase activity
CCF18_RS06540	COG1176	ABC-type spermidine putrescine transport system, permease component I
CCF18_RS06545	COG1177	transmembrane transport
CCF18_RS06555	COG1470	cell adhesion involved in biofilm formation
CCF18_RS06555	COG1388	LysM domain
CCF18_RS06575	COG3238	Protein conserved in bacteria
CCF18_RS06580	COG1247	-acetyltransferase
CCF18_RS06585	COG2130	NADP-dependent
CCF18_RS06600	COG1113	amino acid transport
CCF18_RS06615	COG3209	COG3209 Rhs family protein
CCF18_RS06635	COG3209	COG3209 Rhs family protein
CCF18_RS06635	COG4104	PAAR repeat-containing protein
CCF18_RS06650	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CCF18_RS06660	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CCF18_RS06670	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CCF18_RS06675	COG0384	phenazine biosynthesis protein PhzF
CCF18_RS06685	COG2181	nitrate reductase activity
CCF18_RS06690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CCF18_RS06695	COG1140	nitrate reductase beta subunit
CCF18_RS06700	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CCF18_RS06705	COG2223	nitrite transmembrane transporter activity
CCF18_RS06720	COG0243	molybdopterin cofactor binding
CCF18_RS06720	COG3383	formate dehydrogenase (NAD+) activity
CCF18_RS06725	COG0243	molybdopterin cofactor binding
CCF18_RS06725	COG3383	formate dehydrogenase (NAD+) activity
CCF18_RS06730	COG0437	4 iron, 4 sulfur cluster binding
CCF18_RS06735	COG2864	formate dehydrogenase
CCF18_RS06740	COG3093	addiction module antidote protein HigA
CCF18_RS06750	COG1064	alcohol dehydrogenase
CCF18_RS06765	COG1764	response to oxidative stress
CCF18_RS06770	COG2200	EAL domain
CCF18_RS06770	COG2199	diguanylate cyclase activity
CCF18_RS06770	COG2202	Pas domain
CCF18_RS06780	COG1649	PFAM Uncharacterised BCR, COG1649
CCF18_RS06785	COG0531	amino acid
CCF18_RS06790	COG0076	glutamate decarboxylase activity
CCF18_RS06795	COG0641	radical SAM
CCF18_RS06805	COG2911	Protein conserved in bacteria
CCF18_RS06805	COG3210	domain, Protein
CCF18_RS06825	COG3781	membrane
CCF18_RS06835	COG2199	diguanylate cyclase activity
CCF18_RS06845	COG2066	Belongs to the glutaminase family
CCF18_RS06850	COG1012	belongs to the aldehyde dehydrogenase family
CCF18_RS06855	COG0583	DNA-binding transcription factor activity
CCF18_RS06875	COG1846	Transcriptional regulator
CCF18_RS06880	COG4977	sequence-specific DNA binding
CCF18_RS06890	COG2723	6-phospho-beta-galactosidase activity
CCF18_RS06900	COG1447	Phosphotransferase system cellobiose-specific component IIA
CCF18_RS06905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CCF18_RS06915	COG2188	Transcriptional regulator
CCF18_RS06920	COG0697	spore germination
CCF18_RS06925	COG2814	Major facilitator Superfamily
CCF18_RS06940	COG0339	signal peptide processing
CCF18_RS06945	COG4221	oxidoreductase activity
CCF18_RS06950	COG1802	Transcriptional regulator
CCF18_RS06960	COG0246	Mannitol dehydrogenase
CCF18_RS06965	COG0477	Major facilitator Superfamily
CCF18_RS06970	COG1063	alcohol dehydrogenase
CCF18_RS06975	COG4948	Mandelate Racemase Muconate Lactonizing
CCF18_RS06990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCF18_RS07005	COG0243	molybdopterin cofactor binding
CCF18_RS07010	COG0243	molybdopterin cofactor binding
CCF18_RS07015	COG0437	4 iron, 4 sulfur cluster binding
CCF18_RS07020	COG3302	dmso reductase anchor subunit
CCF18_RS07025	COG3381	protein complex oligomerization
CCF18_RS07035	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CCF18_RS07040	COG1940	carbohydrate kinase activity
CCF18_RS07045	COG0583	DNA-binding transcription factor activity
CCF18_RS07050	COG2814	Major facilitator Superfamily
CCF18_RS07065	COG3591	Belongs to the peptidase S1B family
CCF18_RS07080	COG0628	permease
CCF18_RS07085	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CCF18_RS07090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CCF18_RS07100	COG0531	amino acid
CCF18_RS07110	COG3136	membrane protein required for alginate biosynthesis
CCF18_RS07115	COG0745	RESPONSE REGULATOR receiver
CCF18_RS07120	COG2205	protein histidine kinase activity
CCF18_RS07130	COG0114	fumarate hydratase activity
CCF18_RS07135	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CCF18_RS07135	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CCF18_RS07140	COG1482	cell wall glycoprotein biosynthetic process
CCF18_RS07145	COG5339	Protein conserved in bacteria
CCF18_RS07150	COG1028	Short-chain dehydrogenase reductase Sdr
CCF18_RS07155	COG1609	Transcriptional regulator
CCF18_RS07160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCF18_RS07160	COG1263	PTS System
CCF18_RS07165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CCF18_RS07175	COG0673	inositol 2-dehydrogenase activity
CCF18_RS07215	COG4659	FMN binding
CCF18_RS07225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CCF18_RS07230	COG3104	oligopeptide transport
CCF18_RS07235	COG0625	glutathione transferase activity
CCF18_RS07240	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CCF18_RS07255	COG3895	Periplasmic Protein
CCF18_RS07265	COG3133	Outer membrane lipoprotein
CCF18_RS07280	COG1566	PFAM secretion protein HlyD family protein
CCF18_RS07285	COG1289	transmembrane transporter activity
CCF18_RS07290	COG4989	oxidoreductase activity
CCF18_RS07295	COG3313	Fe-S protein
CCF18_RS07305	COG1309	transcriptional regulator
CCF18_RS07310	COG1902	pentaerythritol trinitrate reductase activity
CCF18_RS07315	COG0346	lactoylglutathione lyase activity
CCF18_RS07325	COG1201	RNA secondary structure unwinding
CCF18_RS07330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CCF18_RS07335	COG0791	NLP P60 protein
CCF18_RS07340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CCF18_RS07355	COG0583	DNA-binding transcription factor activity
CCF18_RS07360	COG2814	Major facilitator Superfamily
CCF18_RS07365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CCF18_RS07370	COG0307	riboflavin synthase, alpha
CCF18_RS07380	COG3468	outer membrane autotransporter barrel domain protein
CCF18_RS07405	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CCF18_RS07410	COG0437	4 iron, 4 sulfur cluster binding
CCF18_RS07420	COG2414	aldehyde ferredoxin oxidoreductase
CCF18_RS07425	COG0437	4 iron, 4 sulfur cluster binding
CCF18_RS07435	COG0469	pyruvate kinase activity
CCF18_RS07440	COG4238	major outer membrane lipoprotein
CCF18_RS07445	COG1376	ErfK ybiS ycfS ynhG family protein
CCF18_RS07460	COG0719	Fe-S assembly protein
CCF18_RS07465	COG0396	ATPase activity
CCF18_RS07470	COG0719	Fe-S assembly protein
CCF18_RS07475	COG0316	Belongs to the HesB IscA family
CCF18_RS07485	COG2050	protein possibly involved in aromatic compounds catabolism
CCF18_RS07490	COG0277	FAD linked oxidase domain protein
CCF18_RS07490	COG0247	lactate metabolic process
CCF18_RS07495	COG0628	permease
CCF18_RS07510	COG0738	Major facilitator superfamily
CCF18_RS07520	COG2271	Major facilitator Superfamily
CCF18_RS07535	COG4670	ketone body catabolic process
CCF18_RS07540	COG1960	acyl-CoA dehydrogenase activity
CCF18_RS07545	COG2207	Transcriptional regulator
CCF18_RS07545	COG1917	Cupin 2, conserved barrel domain protein
CCF18_RS07550	COG2086	electron transfer activity
CCF18_RS07555	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CCF18_RS07560	COG0644	oxidoreductase
CCF18_RS07565	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CCF18_RS07570	COG0318	PFAM AMP-dependent synthetase and ligase
CCF18_RS07575	COG0574	Belongs to the PEP-utilizing enzyme family
CCF18_RS07575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCF18_RS07585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCF18_RS07595	COG2200	EAL domain
CCF18_RS07600	COG0791	NLP P60 protein
CCF18_RS07610	COG0386	Belongs to the glutathione peroxidase family
CCF18_RS07670	COG3137	Salt-induced outer membrane protein
CCF18_RS07675	COG1105	Belongs to the carbohydrate kinase PfkB family
CCF18_RS07685	COG3001	Fructosamine kinase
CCF18_RS07690	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CCF18_RS07695	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CCF18_RS07705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CCF18_RS07710	COG1988	membrane-bound metal-dependent
CCF18_RS07715	COG1823	symporter activity
CCF18_RS07730	COG3394	polysaccharide catabolic process
CCF18_RS07735	COG1486	melibiose metabolic process
CCF18_RS07740	COG1917	Cupin 2, conserved barrel domain protein
CCF18_RS07740	COG2169	Transcriptional regulator
CCF18_RS07745	COG1447	Phosphotransferase system cellobiose-specific component IIA
CCF18_RS07750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CCF18_RS07755	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CCF18_RS07765	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCF18_RS07930	COG3772	lysozyme
CCF18_RS07965	COG1403	HNH endonuclease
CCF18_RS08000	COG1846	Transcriptional regulator
CCF18_RS08005	COG1484	DNA-dependent DNA replication
CCF18_RS08010	COG1846	Transcriptional regulator
CCF18_RS08020	COG4197	protein conserved in bacteria, prophage-related
CCF18_RS08055	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CCF18_RS08065	COG0582	viral genome integration into host DNA
CCF18_RS08075	COG3678	ATP-independent chaperone mediated protein folding
CCF18_RS08105	COG0708	Exodeoxyribonuclease III
CCF18_RS08110	COG0398	Pfam SNARE associated Golgi protein
CCF18_RS08120	COG0398	Pfam SNARE associated Golgi protein
CCF18_RS08125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CCF18_RS08130	COG4134	Bacterial extracellular solute-binding protein
CCF18_RS08140	COG4136	ATPase activity
CCF18_RS08145	COG2897	thiosulfate sulfurtransferase activity
CCF18_RS08160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CCF18_RS08165	COG0494	nUDIX hydrolase
CCF18_RS08175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CCF18_RS08180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CCF18_RS08190	COG0778	Nitroreductase
CCF18_RS08195	COG0616	signal peptide processing
CCF18_RS08205	COG0252	asparaginase activity
CCF18_RS08210	COG1335	isochorismatase
CCF18_RS08225	COG2814	Major facilitator Superfamily
CCF18_RS08230	COG1349	DNA-binding transcription factor activity
CCF18_RS08235	COG0667	Aldo Keto reductase
CCF18_RS08240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCF18_RS08245	COG0191	fructose-bisphosphate aldolase activity
CCF18_RS08250	COG1063	alcohol dehydrogenase
CCF18_RS08255	COG2271	Major facilitator Superfamily
CCF18_RS08260	COG1063	alcohol dehydrogenase
CCF18_RS08265	COG3139	Protein of unknown function (DUF1315)
CCF18_RS08275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CCF18_RS08280	COG0676	glucose-6-phosphate 1-epimerase activity
CCF18_RS08285	COG3713	MltA-interacting MipA family protein
CCF18_RS08290	COG2766	serine protein kinase
CCF18_RS08300	COG2199	diguanylate cyclase activity
CCF18_RS08305	COG2199	diguanylate cyclase activity
CCF18_RS08310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CCF18_RS08325	COG3189	MarR family transcriptional regulator
CCF18_RS08330	COG3042	response to heat
CCF18_RS08335	COG2203	Gaf domain
CCF18_RS08335	COG2199	diguanylate cyclase activity
CCF18_RS08355	COG3615	Tellurite resistance protein tehB
CCF18_RS08365	COG0583	DNA-binding transcription factor activity
CCF18_RS08370	COG0473	3-isopropylmalate dehydrogenase activity
CCF18_RS08375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CCF18_RS08380	COG4638	Rieske (2fe-2S)
CCF18_RS08385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CCF18_RS08390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CCF18_RS08395	COG0318	PFAM AMP-dependent synthetase and ligase
CCF18_RS08400	COG3065	identical protein binding
CCF18_RS08405	COG1214	PFAM Peptidase M22, glycoprotease
CCF18_RS08410	COG1199	ATP-dependent helicase activity
CCF18_RS08415	COG0251	oxidation-reduction process
CCF18_RS08430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CCF18_RS08440	COG1760	l-serine dehydratase
CCF18_RS08445	COG2200	EAL domain
CCF18_RS08450	COG1253	flavin adenine dinucleotide binding
CCF18_RS08455	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS08455	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCF18_RS08460	COG3715	PTS system
CCF18_RS08465	COG3716	PTS system mannose fructose sorbose family IID component
CCF18_RS08480	COG2226	methyltransferase
CCF18_RS08510	COG1414	Transcriptional regulator
CCF18_RS08515	COG2814	Major facilitator Superfamily
CCF18_RS08525	COG0793	Belongs to the peptidase S41A family
CCF18_RS08535	COG1956	GAF domain-containing protein
CCF18_RS08540	COG2995	paraquat-inducible protein a
CCF18_RS08545	COG3008	intermembrane lipid transfer
CCF18_RS08565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CCF18_RS08590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CCF18_RS08610	COG1276	copper resistance
CCF18_RS08615	COG2372	response to copper ion
CCF18_RS08625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CCF18_RS08625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CCF18_RS08630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CCF18_RS08635	COG1770	oligopeptidase
CCF18_RS08645	COG3141	response to X-ray
CCF18_RS08655	COG0800	Aldolase
CCF18_RS08660	COG0129	dihydroxy-acid dehydratase activity
CCF18_RS08665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CCF18_RS08670	COG1737	Transcriptional regulator
CCF18_RS08675	COG0469	pyruvate kinase activity
CCF18_RS08680	COG1560	Kdo2-lipid A biosynthetic process
CCF18_RS08685	COG0739	heme binding
CCF18_RS08690	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CCF18_RS08700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CCF18_RS08730	COG0217	transcriptional regulatory protein
CCF18_RS08735	COG0494	nUDIX hydrolase
CCF18_RS08745	COG1335	isochorismatase
CCF18_RS08750	COG1801	Protein of unknown function DUF72
CCF18_RS08755	COG3788	relative of glutathione S-transferase, MAPEG superfamily
CCF18_RS08770	COG0243	molybdopterin cofactor binding
CCF18_RS08775	COG3005	denitrification pathway
CCF18_RS08785	COG3102	Protein conserved in bacteria
CCF18_RS08800	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CCF18_RS08805	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CCF18_RS08820	COG1360	Flagellar Motor Protein
CCF18_RS08825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CCF18_RS08840	COG0589	response to stress
CCF18_RS08850	COG1877	trehalose-phosphatase activity
CCF18_RS08855	COG1172	Belongs to the binding-protein-dependent transport system permease family
CCF18_RS08865	COG1879	ABC-type sugar transport system periplasmic component
CCF18_RS08870	COG1528	Iron-storage protein
CCF18_RS08890	COG1528	Iron-storage protein
CCF18_RS08900	COG0814	amino acid
CCF18_RS08905	COG3318	Belongs to the UPF0149 family
CCF18_RS08905	COG3012	SEC-C Motif Domain Protein
CCF18_RS08910	COG4974	Belongs to the 'phage' integrase family
CCF18_RS08995	COG4695	Portal protein
CCF18_RS09080	COG5301	cellulose 1,4-beta-cellobiosidase activity
CCF18_RS09100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CCF18_RS09190	COG2197	response regulator
CCF18_RS09205	COG2197	response regulator
CCF18_RS09210	COG1126	abc transporter atp-binding protein
CCF18_RS09215	COG0765	amino acid transport
CCF18_RS09225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCF18_RS09235	COG1191	sigma factor activity
CCF18_RS09245	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CCF18_RS09250	COG1516	flagellar protein fliS
CCF18_RS09260	COG0366	Alpha amylase catalytic
CCF18_RS09270	COG2391	methyltransferase activity
CCF18_RS09275	COG0425	Belongs to the sulfur carrier protein TusA family
CCF18_RS09295	COG1766	The M ring may be actively involved in energy transduction
CCF18_RS09300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCF18_RS09305	COG1317	bacterial-type flagellum organization
CCF18_RS09310	COG1157	protein secretion by the type III secretion system
CCF18_RS09315	COG2882	bacterial-type flagellum organization
CCF18_RS09320	COG3144	bacterial-type flagellum assembly
CCF18_RS09325	COG1580	Controls the rotational direction of flagella during chemotaxis
CCF18_RS09330	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCF18_RS09335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCF18_RS09340	COG3190	flagellar
CCF18_RS09345	COG1338	Plays a role in the flagellum-specific transport system
CCF18_RS09350	COG1987	bacterial-type flagellum assembly
CCF18_RS09355	COG1684	flagellar biosynthetic protein fliR
CCF18_RS09380	COG5475	Uncharacterized small protein (DUF2158)
CCF18_RS09385	COG2354	Protein conserved in bacteria
CCF18_RS09390	COG0697	spore germination
CCF18_RS09395	COG3727	T/G mismatch-specific endonuclease activity
CCF18_RS09400	COG0270	DNA (cytosine-5-)-methyltransferase activity
CCF18_RS09405	COG1418	mRNA catabolic process
CCF18_RS09415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CCF18_RS09425	COG2205	protein histidine kinase activity
CCF18_RS09430	COG0745	RESPONSE REGULATOR receiver
CCF18_RS09435	COG2351	hydroxyisourate hydrolase activity
CCF18_RS09450	COG3443	Belongs to the bacterial solute-binding protein 9 family
CCF18_RS09500	COG5301	cellulose 1,4-beta-cellobiosidase activity
CCF18_RS09605	COG4220	transposase activity
CCF18_RS09630	COG3772	lysozyme
CCF18_RS09690	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CCF18_RS09695	COG1403	HNH endonuclease
CCF18_RS09730	COG1846	Transcriptional regulator
CCF18_RS09735	COG1484	DNA-dependent DNA replication
CCF18_RS09740	COG1846	Transcriptional regulator
CCF18_RS09755	COG1396	sequence-specific DNA binding
CCF18_RS09785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CCF18_RS09815	COG0583	DNA-binding transcription factor activity
CCF18_RS09845	COG0477	Major facilitator Superfamily
CCF18_RS09850	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CCF18_RS09860	COG0534	Mate efflux family protein
CCF18_RS09870	COG1376	ErfK ybiS ycfS ynhG family protein
CCF18_RS09940	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CCF18_RS09955	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CCF18_RS09965	COG1012	belongs to the aldehyde dehydrogenase family
CCF18_RS09970	COG1454	alcohol dehydrogenase
CCF18_RS09970	COG1012	belongs to the aldehyde dehydrogenase family
CCF18_RS09975	COG4656	Part of a membrane complex involved in electron transport
CCF18_RS10000	COG1289	transmembrane transporter activity
CCF18_RS10010	COG1686	Belongs to the peptidase S11 family
CCF18_RS10015	COG2925	Exonuclease
CCF18_RS10020	COG0531	amino acid
CCF18_RS10030	COG0583	DNA-binding transcription factor activity
CCF18_RS10035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CCF18_RS10050	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CCF18_RS10060	COG0131	Imidazoleglycerol-phosphate dehydratase
CCF18_RS10060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CCF18_RS10065	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CCF18_RS10085	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CCF18_RS10090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CCF18_RS10095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CCF18_RS10100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CCF18_RS10110	COG0297	glycogen (starch) synthase activity
CCF18_RS10120	COG1216	Glycosyl transferase, family 2
CCF18_RS10125	COG0463	Glycosyl transferase, family 2
CCF18_RS10150	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CCF18_RS10160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CCF18_RS10170	COG1253	flavin adenine dinucleotide binding
CCF18_RS10175	COG2982	Protein involved in outer membrane biogenesis
CCF18_RS10185	COG0572	uridine kinase
CCF18_RS10190	COG5002	protein histidine kinase activity
CCF18_RS10190	COG3447	MASE1 domain protein
CCF18_RS10190	COG5001	Diguanylate cyclase
CCF18_RS10200	COG0443	Heat shock 70 kDa protein
CCF18_RS10260	COG5301	cellulose 1,4-beta-cellobiosidase activity
CCF18_RS10295	COG1196	nuclear chromosome segregation
CCF18_RS10365	COG4220	transposase activity
CCF18_RS10370	COG3646	Phage regulatory protein
CCF18_RS10380	COG3772	lysozyme
CCF18_RS10595	COG0582	viral genome integration into host DNA
CCF18_RS10620	COG2205	protein histidine kinase activity
CCF18_RS10625	COG0745	RESPONSE REGULATOR receiver
CCF18_RS10635	COG0826	peptidase U32
CCF18_RS10660	COG1830	Aldolase
CCF18_RS10665	COG2211	Major facilitator Superfamily
CCF18_RS10670	COG1397	ADP-ribosylglycohydrolase
CCF18_RS10675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCF18_RS10680	COG2188	Transcriptional regulator
CCF18_RS10705	COG3757	hydrolase, family 25
CCF18_RS10710	COG0351	phosphomethylpyrimidine kinase
CCF18_RS10730	COG5455	response to cobalt ion
CCF18_RS10735	COG3539	Fimbrial protein
CCF18_RS10740	COG3188	usher protein
CCF18_RS10745	COG3121	Chaperone
CCF18_RS10750	COG3539	Fimbrial protein
CCF18_RS10760	COG0489	protein tyrosine kinase activity
CCF18_RS10770	COG3831	ATPase activity
CCF18_RS10775	COG3831	ATPase activity
CCF18_RS10780	COG3831	ATPase activity
CCF18_RS10785	COG3831	ATPase activity
CCF18_RS10795	COG0714	Associated with various cellular activities
CCF18_RS10805	COG3552	Protein containing von Willebrand factor type A (VWA) domain
CCF18_RS10810	COG4715	Zinc finger, swim domain protein
CCF18_RS10815	COG4808	Protein conserved in bacteria
CCF18_RS10820	COG4807	Protein conserved in bacteria
CCF18_RS10825	COG3279	Response regulator of the LytR AlgR family
CCF18_RS10830	COG3275	phosphorelay sensor kinase activity
CCF18_RS10835	COG0789	Transcriptional regulator
CCF18_RS10845	COG1174	glycine betaine transport
CCF18_RS10850	COG1125	glycine betaine transport
CCF18_RS10855	COG1174	glycine betaine transport
CCF18_RS10860	COG1732	Glycine betaine
CCF18_RS10865	COG1472	Belongs to the glycosyl hydrolase 3 family
CCF18_RS10870	COG0277	FAD linked oxidase domain protein
CCF18_RS10875	COG1686	Belongs to the peptidase S11 family
CCF18_RS10885	COG0586	Pfam SNARE associated Golgi protein
CCF18_RS10905	COG1346	cytolysis
CCF18_RS10915	COG2949	membrane
CCF18_RS10925	COG0493	'glutamate synthase
CCF18_RS10930	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CCF18_RS10930	COG0167	dihydroorotate dehydrogenase activity
CCF18_RS10935	COG4211	Belongs to the binding-protein-dependent transport system permease family
CCF18_RS10940	COG1129	ABC transporter
CCF18_RS10945	COG1879	ABC-type sugar transport system periplasmic component
CCF18_RS10950	COG1609	Transcriptional regulator
CCF18_RS10955	COG2311	Membrane
CCF18_RS10970	COG4771	TonB-dependent receptor
CCF18_RS10975	COG0833	amino acid
CCF18_RS10980	COG0583	DNA-binding transcription factor activity
CCF18_RS10985	COG2855	membrane
CCF18_RS10995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCF18_RS10995	COG1522	sequence-specific DNA binding
CCF18_RS11000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CCF18_RS11010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCF18_RS11015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CCF18_RS11020	COG2313	pseudouridylate synthase activity
CCF18_RS11025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCF18_RS11030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCF18_RS11030	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CCF18_RS11030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCF18_RS11035	COG1105	Belongs to the carbohydrate kinase PfkB family
CCF18_RS11040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS11040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS11045	COG2814	Major facilitator Superfamily
CCF18_RS11060	COG0246	Mannitol dehydrogenase
CCF18_RS11065	COG0523	cobalamin synthesis protein
CCF18_RS11070	COG0671	phosphoesterase, PA-phosphatase related
CCF18_RS11075	COG0791	NLP P60 protein
CCF18_RS11080	COG2200	EAL domain
CCF18_RS11085	COG4166	transmembrane transport
CCF18_RS11090	COG4174	ABC transporter (Permease)
CCF18_RS11095	COG4239	(ABC) transporter, permease
CCF18_RS11100	COG4172	Belongs to the ABC transporter superfamily
CCF18_RS11115	COG2814	Major facilitator Superfamily
CCF18_RS11120	COG1187	pseudouridine synthase activity
CCF18_RS11125	COG1061	Type III restriction enzyme res subunit
CCF18_RS11140	COG3976	FMN-binding domain protein
CCF18_RS11140	COG1053	succinate dehydrogenase
CCF18_RS11140	COG0431	NADPH-dependent FMN reductase
CCF18_RS11160	COG3083	sulfuric ester hydrolase activity
CCF18_RS11170	COG3468	outer membrane autotransporter barrel domain protein
CCF18_RS11175	COG2197	response regulator
CCF18_RS11180	COG4235	cytochrome complex assembly
CCF18_RS11180	COG3088	subunit of a heme lyase
CCF18_RS11185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CCF18_RS11190	COG1138	Cytochrome C-type biogenesis protein
CCF18_RS11200	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CCF18_RS11205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CCF18_RS11210	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CCF18_RS11215	COG4133	protoheme IX ABC transporter activity
CCF18_RS11220	COG3005	denitrification pathway
CCF18_RS11225	COG3043	anaerobic respiration
CCF18_RS11230	COG0348	domain, Protein
CCF18_RS11235	COG0437	4 iron, 4 sulfur cluster binding
CCF18_RS11245	COG3062	negative regulation of establishment of protein localization
CCF18_RS11250	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCF18_RS11250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCF18_RS11265	COG4615	Cyclic peptide transporter
CCF18_RS11270	COG3145	DNA-N1-methyladenine dioxygenase activity
CCF18_RS11275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CCF18_RS11275	COG2169	Transcriptional regulator
CCF18_RS11280	COG1477	protein flavinylation
CCF18_RS11285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CCF18_RS11290	COG0642	Histidine kinase
CCF18_RS11290	COG2198	Histidine kinase
CCF18_RS11295	COG2197	response regulator
CCF18_RS11305	COG0784	Response regulator, receiver
CCF18_RS11305	COG2205	protein histidine kinase activity
CCF18_RS11315	COG4676	Protein conserved in bacteria
CCF18_RS11320	COG5445	Predicted secreted protein (DUF2300)
CCF18_RS11325	COG2373	Large extracellular alpha-helical protein
CCF18_RS11330	COG3234	Protein of unknown function (DUF1175)
CCF18_RS11340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CCF18_RS11345	COG1120	ATPase activity
CCF18_RS11350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCF18_RS11390	COG3468	outer membrane autotransporter barrel domain protein
CCF18_RS11395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCF18_RS11400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCF18_RS11405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CCF18_RS11410	COG2814	Major facilitator Superfamily
CCF18_RS11415	COG0583	DNA-binding transcription factor activity
CCF18_RS11420	COG0584	glycerophosphoryl diester phosphodiesterase
CCF18_RS11425	COG2271	Major facilitator Superfamily
CCF18_RS11430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CCF18_RS11440	COG0247	lactate metabolic process
CCF18_RS11445	COG5464	transposase or invertase
CCF18_RS11455	COG2271	Major facilitator Superfamily
CCF18_RS11465	COG1414	Transcriptional regulator
CCF18_RS11530	COG0318	PFAM AMP-dependent synthetase and ligase
CCF18_RS11540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CCF18_RS11555	COG1169	isochorismate synthase
CCF18_RS11560	COG4575	ribosome binding
CCF18_RS11565	COG2153	protein acetylation
CCF18_RS11575	COG2304	oxidoreductase activity
CCF18_RS11580	COG2234	aminopeptidase activity
CCF18_RS11615	COG0457	Tetratricopeptide repeat
CCF18_RS11625	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCF18_RS11630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CCF18_RS11640	COG0839	Belongs to the complex I subunit 6 family
CCF18_RS11655	COG1034	ATP synthesis coupled electron transport
CCF18_RS11660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CCF18_RS11665	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CCF18_RS11685	COG0583	DNA-binding transcription factor activity
CCF18_RS11690	COG0436	Aminotransferase
CCF18_RS11700	COG0490	domain, Protein
CCF18_RS11700	COG0471	metal ion transport
CCF18_RS11705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CCF18_RS11720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CCF18_RS11725	COG0280	phosphate acetyltransferase
CCF18_RS11725	COG0857	belongs to the CobB CobQ family
CCF18_RS11730	COG1288	antiporter activity
CCF18_RS11735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CCF18_RS11740	COG3959	Transketolase, thiamine diphosphate binding domain
CCF18_RS11745	COG3037	sugar-specific permease SgaT UlaA
CCF18_RS11755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS11760	COG1609	Transcriptional regulator
CCF18_RS11765	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CCF18_RS11770	COG0622	Phosphoesterase
CCF18_RS11780	COG0625	glutathione transferase activity
CCF18_RS11785	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CCF18_RS11790	COG1090	epimerase
CCF18_RS11795	COG5464	transposase or invertase
CCF18_RS11800	COG4598	ABC transporter
CCF18_RS11805	COG4160	amino acid transport
CCF18_RS11810	COG4215	(ABC) transporter
CCF18_RS11815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCF18_RS11820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCF18_RS11825	COG0163	prenyltransferase activity
CCF18_RS11830	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CCF18_RS11835	COG1286	toxin biosynthetic process
CCF18_RS11840	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CCF18_RS11845	COG0285	dihydrofolate synthase activity
CCF18_RS11855	COG0586	Pfam SNARE associated Golgi protein
CCF18_RS11865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CCF18_RS11880	COG2814	Major facilitator Superfamily
CCF18_RS11885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CCF18_RS11900	COG3101	peptidyl-lysine hydroxylation
CCF18_RS11905	COG0730	response to heat
CCF18_RS11935	COG3539	Fimbrial protein
CCF18_RS11940	COG3539	Fimbrial protein
CCF18_RS11945	COG3539	Fimbrial protein
CCF18_RS11950	COG3121	Chaperone
CCF18_RS11955	COG3188	usher protein
CCF18_RS11960	COG3539	Fimbrial protein
CCF18_RS11965	COG2062	phosphohistidine phosphatase, SixA
CCF18_RS11970	COG1024	Enoyl-CoA hydratase
CCF18_RS11970	COG1250	3-hydroxyacyl-CoA dehydrogenase
CCF18_RS11980	COG3691	Protein conserved in bacteria
CCF18_RS11985	COG2067	long-chain fatty acid transport protein
CCF18_RS11990	COG2853	Lipoprotein
CCF18_RS12000	COG0583	DNA-binding transcription factor activity
CCF18_RS12005	COG2610	gluconate transmembrane transporter activity
CCF18_RS12020	COG1560	Kdo2-lipid A biosynthetic process
CCF18_RS12030	COG0436	Aminotransferase
CCF18_RS12035	COG3275	phosphorelay sensor kinase activity
CCF18_RS12040	COG3279	Response regulator of the LytR AlgR family
CCF18_RS12045	COG2207	Transcriptional regulator
CCF18_RS12050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCF18_RS12050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS12050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS12055	COG1363	Peptidase, m42
CCF18_RS12060	COG0006	proline dipeptidase activity
CCF18_RS12065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCF18_RS12070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCF18_RS12095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CCF18_RS12100	COG2199	diguanylate cyclase activity
CCF18_RS12100	COG2200	EAL domain
CCF18_RS12115	COG3415	Transposase
CCF18_RS12120	COG3415	Transposase
CCF18_RS12150	COG0583	DNA-binding transcription factor activity
CCF18_RS12155	COG2211	Major facilitator Superfamily
CCF18_RS12160	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CCF18_RS12170	COG2211	Major facilitator Superfamily
CCF18_RS12175	COG0385	Bile acid
CCF18_RS12180	COG3530	Putative quorum-sensing-regulated virulence factor
CCF18_RS12200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CCF18_RS12205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS12210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCF18_RS12215	COG2190	(PTS) system
CCF18_RS12230	COG3831	ATPase activity
CCF18_RS12230	COG4884	unkown
CCF18_RS12240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CCF18_RS12245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CCF18_RS12250	COG4208	sulfate ABC transporter
CCF18_RS12255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CCF18_RS12260	COG4150	thiosulfate binding
CCF18_RS12265	COG1028	Short-chain dehydrogenase reductase Sdr
CCF18_RS12275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCF18_RS12275	COG1263	PTS System
CCF18_RS12285	COG2837	iron assimilation
CCF18_RS12305	COG0860	N-Acetylmuramoyl-L-alanine amidase
CCF18_RS12325	COG2207	Transcriptional regulator
CCF18_RS12330	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CCF18_RS12335	COG4816	utilization protein
CCF18_RS12345	COG4303	Ethanolamine ammonia lyase large subunit
CCF18_RS12350	COG4819	ethanolamine utilization protein
CCF18_RS12360	COG1454	alcohol dehydrogenase
CCF18_RS12365	COG4820	ethanolamine utilization protein (EutJ)
CCF18_RS12370	COG1012	belongs to the aldehyde dehydrogenase family
CCF18_RS12375	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
CCF18_RS12380	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CCF18_RS12385	COG0280	phosphate acetyltransferase
CCF18_RS12390	COG4812	Cobalamin adenosyltransferase
CCF18_RS12395	COG4766	ethanolamine catabolic process
CCF18_RS12400	COG4917	ethanolamine utilization protein
CCF18_RS12405	COG4810	utilization protein
CCF18_RS12410	COG0280	phosphate acetyltransferase
CCF18_RS12410	COG0281	malic enzyme
CCF18_RS12425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CCF18_RS12435	COG0493	'glutamate synthase
CCF18_RS12435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCF18_RS12440	COG3850	Histidine kinase
CCF18_RS12445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCF18_RS12455	COG1393	Belongs to the ArsC family
CCF18_RS12470	COG0400	carboxylic ester hydrolase activity
CCF18_RS12475	COG1444	tRNA N-acetyltransferase activity
CCF18_RS12480	COG2321	neutral zinc metallopeptidase
CCF18_RS12490	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CCF18_RS12500	COG2716	regulation of RNA biosynthetic process
CCF18_RS12505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CCF18_RS12510	COG0628	permease
CCF18_RS12515	COG4783	chaperone-mediated protein folding
CCF18_RS12520	COG1393	Belongs to the ArsC family
CCF18_RS12530	COG2233	PERMEase
CCF18_RS12545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CCF18_RS12550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CCF18_RS12555	COG0248	Ppx GppA phosphatase
CCF18_RS12560	COG2200	EAL domain
CCF18_RS12570	COG3133	Outer membrane lipoprotein
CCF18_RS12585	COG3179	chitinase
CCF18_RS12800	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CCF18_RS12840	COG0517	IMP dehydrogenase activity
CCF18_RS12840	COG0516	GMP reductase activity
CCF18_RS12860	COG1470	cell adhesion involved in biofilm formation
CCF18_RS12860	COG1388	LysM domain
CCF18_RS12865	COG1645	bacterial-type flagellum-dependent swarming motility
CCF18_RS12880	COG2976	Protein conserved in bacteria
CCF18_RS12910	COG4953	penicillin-binding protein 1C
CCF18_RS12915	COG2373	Large extracellular alpha-helical protein
CCF18_RS12920	COG2897	thiosulfate sulfurtransferase activity
CCF18_RS12935	COG2975	iron-sulfur cluster assembly
CCF18_RS12940	COG0633	Ferredoxin
CCF18_RS12960	COG0822	iron-sulfur transferase activity
CCF18_RS12980	COG0483	inositol monophosphate 1-phosphatase activity
CCF18_RS12985	COG1073	alpha beta
CCF18_RS12990	COG3711	transcriptional antiterminator
CCF18_RS12995	COG2814	Major facilitator Superfamily
CCF18_RS13005	COG2259	Doxx family
CCF18_RS13010	COG2017	converts alpha-aldose to the beta-anomer
CCF18_RS13015	COG1063	alcohol dehydrogenase
CCF18_RS13020	COG1172	Belongs to the binding-protein-dependent transport system permease family
CCF18_RS13025	COG1129	ABC transporter
CCF18_RS13030	COG1879	ABC-type sugar transport system periplasmic component
CCF18_RS13035	COG0457	Tetratricopeptide repeat
CCF18_RS13040	COG1940	carbohydrate kinase activity
CCF18_RS13050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CCF18_RS13050	COG1017	nitric oxide dioxygenase activity
CCF18_RS13055	COG0347	Belongs to the P(II) protein family
CCF18_RS13060	COG2204	response regulator
CCF18_RS13065	COG3170	Tfp pilus assembly protein FimV
CCF18_RS13070	COG2205	protein histidine kinase activity
CCF18_RS13080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CCF18_RS13080	COG0047	phosphoribosylformylglycinamidine synthase activity
CCF18_RS13095	COG0560	Phosphoserine phosphatase
CCF18_RS13100	COG1737	Transcriptional regulator
CCF18_RS13105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCF18_RS13120	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CCF18_RS13140	COG0681	Belongs to the peptidase S26 family
CCF18_RS13150	COG3086	response to oxidative stress
CCF18_RS13155	COG3026	antisigma factor binding
CCF18_RS13160	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
CCF18_RS13165	COG1595	DNA-templated transcription, initiation
CCF18_RS13175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CCF18_RS13185	COG0513	Belongs to the DEAD box helicase family
CCF18_RS13190	COG0583	DNA-binding transcription factor activity
CCF18_RS13220	COG2271	Major facilitator Superfamily
CCF18_RS13230	COG1960	acyl-CoA dehydrogenase activity
CCF18_RS13240	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CCF18_RS13255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CCF18_RS13260	COG3118	belongs to the thioredoxin family
CCF18_RS13265	COG3148	PFAM DTW domain containing protein
CCF18_RS13270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CCF18_RS13270	COG0045	succinate-CoA ligase (ADP-forming) activity
CCF18_RS13270	COG1042	CoA-binding domain protein
CCF18_RS13275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CCF18_RS13280	COG5544	Lipoprotein
CCF18_RS13285	COG0477	Major facilitator Superfamily
CCF18_RS13315	COG0542	response to heat
CCF18_RS13325	COG0564	pseudouridine synthase activity
CCF18_RS13330	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCF18_RS13335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CCF18_RS13345	COG1605	Chorismate mutase
CCF18_RS13345	COG0077	Prephenate dehydratase
CCF18_RS13350	COG1605	Chorismate mutase
CCF18_RS13350	COG0287	Prephenate dehydrogenase
CCF18_RS13355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CCF18_RS13370	COG2199	diguanylate cyclase activity
CCF18_RS13375	COG2885	chlorophyll binding
CCF18_RS13400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CCF18_RS13405	COG4137	Cytochrome C assembly protein
CCF18_RS13410	COG4536	flavin adenine dinucleotide binding
CCF18_RS13430	COG0497	DNA recombination
CCF18_RS13435	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCF18_RS13450	COG2867	negative regulation of translational initiation
CCF18_RS13490	COG0366	Alpha amylase catalytic
CCF18_RS13500	COG0579	oxidoreductase
CCF18_RS13505	COG1012	belongs to the aldehyde dehydrogenase family
CCF18_RS13510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CCF18_RS13515	COG1113	amino acid transport
CCF18_RS13520	COG1802	Transcriptional regulator
CCF18_RS13525	COG0401	homolog of Blt101
CCF18_RS13530	COG0640	Transcriptional regulator
CCF18_RS13535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCF18_RS13540	COG2916	Histone family protein nucleoid-structuring protein H-NS
CCF18_RS13555	COG4575	ribosome binding
CCF18_RS13565	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CCF18_RS13570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CCF18_RS13580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCF18_RS13585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCF18_RS13595	COG4175	Glycine betaine
CCF18_RS13600	COG4176	ABC-type proline glycine betaine transport system permease component
CCF18_RS13605	COG2113	Glycine betaine
CCF18_RS13610	COG2814	Major facilitator Superfamily
CCF18_RS13615	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CCF18_RS13625	COG1846	Transcriptional regulator
CCF18_RS13630	COG1566	PFAM secretion protein HlyD family protein
CCF18_RS13635	COG2814	Major facilitator Superfamily
CCF18_RS13660	COG1238	metal cluster binding
CCF18_RS13665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CCF18_RS13695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CCF18_RS13715	COG1546	Belongs to the CinA family
CCF18_RS13725	COG2951	lytic endotransglycosylase activity
CCF18_RS13730	COG3730	PTS system glucitol sorbitol-specific
CCF18_RS13735	COG3732	PTS system glucitol sorbitol-specific
CCF18_RS13745	COG1028	Short-chain dehydrogenase reductase Sdr
CCF18_RS13750	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS13755	COG1349	DNA-binding transcription factor activity
CCF18_RS13760	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CCF18_RS13760	COG0517	IMP dehydrogenase activity
CCF18_RS13780	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CCF18_RS13785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCF18_RS13795	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CCF18_RS13805	COG3260	NADH ubiquinone oxidoreductase 20
CCF18_RS13810	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCF18_RS13815	COG3261	NADH dehydrogenase
CCF18_RS13815	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CCF18_RS13820	COG0650	Formate hydrogenlyase subunit 4
CCF18_RS13825	COG0651	ATP synthesis coupled electron transport
CCF18_RS13830	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCF18_RS13840	COG0375	protein maturation
CCF18_RS13845	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CCF18_RS13850	COG0298	carbon dioxide binding
CCF18_RS13855	COG0409	Hydrogenase expression formation protein
CCF18_RS13860	COG0309	Hydrogenase expression formation protein (HypE)
CCF18_RS13865	COG3604	Transcriptional regulator
CCF18_RS13885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CCF18_RS13895	COG1388	LysM domain
CCF18_RS13895	COG2373	Large extracellular alpha-helical protein
CCF18_RS13895	COG4932	domain protein
CCF18_RS13905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CCF18_RS13910	COG0163	prenyltransferase activity
CCF18_RS13920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CCF18_RS13925	COG4942	peptidase
CCF18_RS13925	COG1388	LysM domain
CCF18_RS13940	COG0585	pseudouridine synthase activity
CCF18_RS13980	COG2234	aminopeptidase activity
CCF18_RS13985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CCF18_RS13990	COG1518	maintenance of DNA repeat elements
CCF18_RS14005	COG1857	crispr-associated protein
CCF18_RS14020	COG1203	CRISPR-associated helicase, Cas3
CCF18_RS14025	COG3385	transposase activity
CCF18_RS14055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CCF18_RS14060	COG0720	synthase
CCF18_RS14065	COG0644	oxidoreductase
CCF18_RS14070	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CCF18_RS14075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CCF18_RS14080	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CCF18_RS14085	COG2086	electron transfer activity
CCF18_RS14090	COG0477	Major facilitator Superfamily
CCF18_RS14095	COG0277	FAD linked oxidase domain protein
CCF18_RS14100	COG1028	Short-chain dehydrogenase reductase Sdr
CCF18_RS14105	COG2223	nitrite transmembrane transporter activity
CCF18_RS14110	COG1070	Carbohydrate kinase
CCF18_RS14115	COG0602	queuosine metabolic process
CCF18_RS14125	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CCF18_RS14135	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CCF18_RS14150	COG3956	TIGRFAM MazG family protein
CCF18_RS14155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CCF18_RS14160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CCF18_RS14165	COG3437	response regulator, receiver
CCF18_RS14165	COG3850	Histidine kinase
CCF18_RS14165	COG2205	protein histidine kinase activity
CCF18_RS14165	COG4999	Histidine kinase
CCF18_RS14170	COG0716	FMN binding
CCF18_RS14175	COG0564	pseudouridine synthase activity
CCF18_RS14180	COG3098	single-species biofilm formation
CCF18_RS14195	COG1611	Belongs to the LOG family
CCF18_RS14200	COG0814	amino acid
CCF18_RS14205	COG1760	l-serine dehydratase
CCF18_RS14215	COG1454	alcohol dehydrogenase
CCF18_RS14220	COG0235	Class ii aldolase
CCF18_RS14225	COG0738	Major facilitator superfamily
CCF18_RS14235	COG1070	Carbohydrate kinase
CCF18_RS14245	COG1349	DNA-binding transcription factor activity
CCF18_RS14255	COG2363	Small membrane protein
CCF18_RS14260	COG0583	DNA-binding transcription factor activity
CCF18_RS14270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CCF18_RS14275	COG2166	iron-sulfur cluster assembly
CCF18_RS14280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CCF18_RS14285	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CCF18_RS14305	COG0860	N-Acetylmuramoyl-L-alanine amidase
CCF18_RS14310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CCF18_RS14310	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CCF18_RS14315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CCF18_RS14320	COG1074	ATP-dependent DNA helicase activity
CCF18_RS14325	COG1025	Belongs to the peptidase M16 family
CCF18_RS14330	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CCF18_RS14335	COG4967	type IV pilus modification protein PilV
CCF18_RS14345	COG4795	General secretion pathway protein
CCF18_RS14350	COG2165	general secretion pathway protein
CCF18_RS14365	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CCF18_RS14380	COG0861	Integral membrane protein TerC family
CCF18_RS14390	COG0667	Aldo Keto reductase
CCF18_RS14415	COG1609	Transcriptional regulator
CCF18_RS14425	COG0583	DNA-binding transcription factor activity
CCF18_RS14430	COG1794	racemase activity, acting on amino acids and derivatives
CCF18_RS14435	COG0183	Belongs to the thiolase family
CCF18_RS14440	COG0814	amino acid
CCF18_RS14445	COG2771	luxR family
CCF18_RS14450	COG3710	Transcriptional regulator
CCF18_RS14465	COG0457	Tetratricopeptide repeat
CCF18_RS14470	COG0457	Tetratricopeptide repeat
CCF18_RS14470	COG3710	Transcriptional regulator
CCF18_RS14480	COG0741	lytic transglycosylase activity
CCF18_RS14485	COG2197	response regulator
CCF18_RS14585	COG2207	Transcriptional regulator
CCF18_RS14595	COG3387	PFAM Glycoside hydrolase 15-related
CCF18_RS14605	COG4942	peptidase
CCF18_RS14610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CCF18_RS14615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CCF18_RS14620	COG2080	2 iron, 2 sulfur cluster binding
CCF18_RS14625	COG3829	transcription factor binding
CCF18_RS14630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CCF18_RS14635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CCF18_RS14640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CCF18_RS14650	COG0549	Belongs to the carbamate kinase family
CCF18_RS14655	COG3608	succinylglutamate desuccinylase aspartoacylase
CCF18_RS14655	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CCF18_RS14660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CCF18_RS14665	COG2068	MobA-Related Protein
CCF18_RS14670	COG0493	'glutamate synthase
CCF18_RS14670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCF18_RS14675	COG0402	S-adenosylhomocysteine deaminase activity
CCF18_RS14680	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CCF18_RS14685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CCF18_RS14685	COG2080	2 iron, 2 sulfur cluster binding
CCF18_RS14690	COG2233	PERMEase
CCF18_RS14695	COG0402	S-adenosylhomocysteine deaminase activity
CCF18_RS14700	COG2252	PERMEase
CCF18_RS14705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCF18_RS14710	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCF18_RS14710	COG0493	'glutamate synthase
CCF18_RS14715	COG2233	PERMEase
CCF18_RS14725	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CCF18_RS14730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CCF18_RS14740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CCF18_RS14745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CCF18_RS14750	COG4974	Belongs to the 'phage' integrase family
CCF18_RS14755	COG0716	FMN binding
CCF18_RS14765	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CCF18_RS14775	COG1272	protein, Hemolysin III
CCF18_RS14785	COG2723	6-phospho-beta-galactosidase activity
CCF18_RS14820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCF18_RS14825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CCF18_RS14830	COG0006	proline dipeptidase activity
CCF18_RS14850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CCF18_RS14860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CCF18_RS14875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CCF18_RS14875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CCF18_RS14880	COG1703	isobutyryl-CoA mutase activity
CCF18_RS14885	COG1024	Enoyl-CoA hydratase
CCF18_RS14890	COG0427	acetyl-CoA hydrolase
CCF18_RS14895	COG0583	DNA-binding transcription factor activity
CCF18_RS14900	COG2968	Membrane
CCF18_RS14905	COG1279	arginine transmembrane transporter activity
CCF18_RS14915	COG0668	transmembrane transport
CCF18_RS14920	COG0191	fructose-bisphosphate aldolase activity
CCF18_RS14935	COG1072	(Pantothenic acid kinase))
CCF18_RS14945	COG1494	fructose-1,6-bisphosphatase
CCF18_RS14950	COG1063	alcohol dehydrogenase
CCF18_RS14955	COG2213	PTS system mannitol-specific
CCF18_RS14960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS14965	COG0330	HflC and HflK could
CCF18_RS14970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CCF18_RS14975	COG0501	Belongs to the peptidase M48B family
CCF18_RS14995	COG4948	Mandelate Racemase Muconate Lactonizing
CCF18_RS15005	COG1028	Short-chain dehydrogenase reductase Sdr
CCF18_RS15010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CCF18_RS15015	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CCF18_RS15020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CCF18_RS15025	COG1166	arginine decarboxylase activity
CCF18_RS15050	COG2814	Major facilitator Superfamily
CCF18_RS15060	COG2356	endonuclease I
CCF18_RS15065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CCF18_RS15070	COG0189	ligase activity
CCF18_RS15085	COG2805	Type II/IV secretion system protein
CCF18_RS15090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CCF18_RS15095	COG0762	integral membrane protein
CCF18_RS15110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CCF18_RS15120	COG0252	asparaginase activity
CCF18_RS15130	COG3171	Protein conserved in bacteria
CCF18_RS15140	COG1194	a g-specific adenine glycosylase
CCF18_RS15155	COG2211	Major facilitator Superfamily
CCF18_RS15160	COG1982	Orn Lys Arg decarboxylase major
CCF18_RS15165	COG1811	Na channel or pump
CCF18_RS15180	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CCF18_RS15195	COG0583	DNA-binding transcription factor activity
CCF18_RS15200	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CCF18_RS15230	COG2165	general secretion pathway protein
CCF18_RS15235	COG1459	type II secretion system
CCF18_RS15240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CCF18_RS15260	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CCF18_RS15280	COG3064	Membrane
CCF18_RS15285	COG1620	l-lactate permease
CCF18_RS15290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CCF18_RS15295	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CCF18_RS15300	COG0247	lactate metabolic process
CCF18_RS15305	COG0277	FAD linked oxidase domain protein
CCF18_RS15310	COG0277	FAD linked oxidase domain protein
CCF18_RS15315	COG2186	Transcriptional regulator
CCF18_RS15320	COG0456	acetyltransferase
CCF18_RS15325	COG0318	PFAM AMP-dependent synthetase and ligase
CCF18_RS15335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CCF18_RS15340	COG0156	8-amino-7-oxononanoate synthase activity
CCF18_RS15350	COG0795	lipopolysaccharide-transporting ATPase activity
CCF18_RS15355	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CCF18_RS15365	COG2244	polysaccharide biosynthetic process
CCF18_RS15370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CCF18_RS15375	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CCF18_RS15380	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CCF18_RS15385	COG0306	phosphate transporter
CCF18_RS15390	COG0754	glutathionylspermidine amidase activity
CCF18_RS15395	COG0625	glutathione transferase activity
CCF18_RS15400	COG0298	carbon dioxide binding
CCF18_RS15405	COG0375	protein maturation
CCF18_RS15410	COG1773	rubredoxin
CCF18_RS15415	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CCF18_RS15420	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CCF18_RS15425	COG5557	Pfam Polysulphide reductase, NrfD
CCF18_RS15430	COG0437	4 iron, 4 sulfur cluster binding
CCF18_RS15435	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CCF18_RS15440	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CCF18_RS15445	COG0644	oxidoreductase
CCF18_RS15450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CCF18_RS15455	COG2086	electron transfer activity
CCF18_RS15465	COG2610	gluconate transmembrane transporter activity
CCF18_RS15480	COG1924	4 iron, 4 sulfur cluster binding
CCF18_RS15490	COG0318	PFAM AMP-dependent synthetase and ligase
CCF18_RS15495	COG4977	sequence-specific DNA binding
CCF18_RS15505	COG0667	Aldo Keto reductase
CCF18_RS15510	COG0848	biopolymer transport protein
CCF18_RS15515	COG0811	peptide transport
CCF18_RS15520	COG0626	cystathionine gamma-synthase activity
CCF18_RS15525	COG0586	Pfam SNARE associated Golgi protein
CCF18_RS15530	COG2207	Transcriptional regulator
CCF18_RS15535	COG1979	alcohol dehydrogenase
CCF18_RS15540	COG0656	L-ascorbic acid biosynthetic process
CCF18_RS15570	COG4238	major outer membrane lipoprotein
CCF18_RS15575	COG1032	radical SAM domain protein
CCF18_RS15580	COG2186	Transcriptional regulator
CCF18_RS15585	COG0246	Mannitol dehydrogenase
CCF18_RS15590	COG1063	alcohol dehydrogenase
CCF18_RS15595	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CCF18_RS15630	COG2132	Multicopper oxidase
CCF18_RS15635	COG0204	Acyl-transferase
CCF18_RS15640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CCF18_RS15645	COG4166	transmembrane transport
CCF18_RS15650	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CCF18_RS15655	COG3111	PFAM Bacterial OB fold (BOF) protein
CCF18_RS15660	COG0745	RESPONSE REGULATOR receiver
CCF18_RS15665	COG0642	Histidine kinase
CCF18_RS15670	COG2249	NAD(P)H dehydrogenase (quinone) activity
CCF18_RS15675	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
CCF18_RS15680	COG0187	DNA topoisomerase II activity
CCF18_RS15685	COG3150	esterase
CCF18_RS15690	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CCF18_RS15695	COG3151	Protein conserved in bacteria
CCF18_RS15700	COG0494	nUDIX hydrolase
CCF18_RS15705	COG1538	Outer membrane efflux protein
CCF18_RS15715	COG0754	glutathionylspermidine amidase activity
CCF18_RS15725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CCF18_RS15735	COG3384	dioxygenase
CCF18_RS15745	COG3539	Fimbrial protein
CCF18_RS15750	COG3188	usher protein
CCF18_RS15755	COG3121	Chaperone
CCF18_RS15760	COG3539	Fimbrial protein
CCF18_RS15780	COG1585	Membrane protein implicated in regulation of membrane protease activity
CCF18_RS15785	COG2268	Band 7 protein
CCF18_RS15815	COG3025	triphosphatase activity
CCF18_RS15820	COG4991	sh3 domain protein
CCF18_RS15835	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CCF18_RS15855	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CCF18_RS15860	COG0471	metal ion transport
CCF18_RS15870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CCF18_RS15875	COG0358	DNA primase activity
CCF18_RS15880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CCF18_RS15895	COG2375	cellular response to nickel ion
CCF18_RS15905	COG1695	Transcriptional regulator
CCF18_RS15915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCF18_RS15920	COG1609	Transcriptional regulator
CCF18_RS15925	COG3250	beta-galactosidase activity
CCF18_RS15930	COG2731	YhcH YjgK YiaL family protein
CCF18_RS15935	COG0531	amino acid
CCF18_RS15945	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CCF18_RS15945	COG3408	Glycogen debranching enzyme
CCF18_RS15950	COG0446	pyridine nucleotide-disulphide oxidoreductase
CCF18_RS15950	COG1902	pentaerythritol trinitrate reductase activity
CCF18_RS15955	COG5499	transcription regulator containing HTH domain
CCF18_RS15970	COG1451	nucleotide metabolic process
CCF18_RS15975	COG2949	membrane
CCF18_RS15980	COG0673	inositol 2-dehydrogenase activity
CCF18_RS15990	COG0861	Integral membrane protein TerC family
CCF18_RS15995	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CCF18_RS16005	COG2721	sulfolactate sulfo-lyase activity
CCF18_RS16015	COG2271	Major facilitator Superfamily
CCF18_RS16020	COG2186	Transcriptional regulator
CCF18_RS16025	COG0586	Pfam SNARE associated Golgi protein
CCF18_RS16035	COG1422	Protein of unknown function (DUF1090)
CCF18_RS16040	COG4575	ribosome binding
CCF18_RS16045	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
CCF18_RS16055	COG2259	Doxx family
CCF18_RS16065	COG0435	Glutathione S-transferase
CCF18_RS16070	COG3152	Membrane
CCF18_RS16075	COG0583	DNA-binding transcription factor activity
CCF18_RS16080	COG1741	Belongs to the pirin family
CCF18_RS16095	COG0814	amino acid
CCF18_RS16105	COG1760	l-serine dehydratase
CCF18_RS16110	COG0251	oxidation-reduction process
CCF18_RS16115	COG1882	Formate acetyltransferase
CCF18_RS16120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CCF18_RS16130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CCF18_RS16135	COG0583	DNA-binding transcription factor activity
CCF18_RS16150	COG1929	Belongs to the glycerate kinase type-1 family
CCF18_RS16155	COG2084	Dehydrogenase
CCF18_RS16165	COG2271	Major facilitator Superfamily
CCF18_RS16170	COG2721	sulfolactate sulfo-lyase activity
CCF18_RS16175	COG2002	toxin-antitoxin pair type II binding
CCF18_RS16185	COG1349	DNA-binding transcription factor activity
CCF18_RS16195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCF18_RS16205	COG3716	PTS system mannose fructose sorbose family IID component
CCF18_RS16210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS16215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CCF18_RS16235	COG2222	sugar isomerase
CCF18_RS16245	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCF18_RS16250	COG3715	PTS system
CCF18_RS16255	COG3716	PTS system mannose fructose sorbose family IID component
CCF18_RS16260	COG0363	glucosamine-6-phosphate deaminase activity
CCF18_RS16265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CCF18_RS16270	COG3107	peptidoglycan biosynthetic process
CCF18_RS16285	COG2823	Periplasmic or secreted lipoprotein
CCF18_RS16290	COG0702	epimerase
CCF18_RS16305	COG3153	acetyltransferase
CCF18_RS16310	COG3154	lipid carrier protein
CCF18_RS16315	COG0826	peptidase U32
CCF18_RS16320	COG0826	peptidase U32
CCF18_RS16325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CCF18_RS16330	COG0814	amino acid
CCF18_RS16335	COG0513	Belongs to the DEAD box helicase family
CCF18_RS16375	COG0195	Participates in both transcription termination and antitermination
CCF18_RS16400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CCF18_RS16415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CCF18_RS16420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CCF18_RS16430	COG1534	Rna-binding protein
CCF18_RS16435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CCF18_RS16440	COG2027	D-alanyl-D-alanine carboxypeptidase
CCF18_RS16450	COG0697	spore germination
CCF18_RS16465	COG0142	geranyltranstransferase activity
CCF18_RS16470	COG3423	Transcriptional regulator
CCF18_RS16480	COG5007	Belongs to the BolA IbaG family
CCF18_RS16485	COG3113	response to antibiotic
CCF18_RS16490	COG2854	intermembrane phospholipid transfer
CCF18_RS16495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CCF18_RS16500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CCF18_RS16505	COG1127	ABC transporter
CCF18_RS16510	COG0530	calcium, potassium:sodium antiporter activity
CCF18_RS16515	COG0517	IMP dehydrogenase activity
CCF18_RS16515	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CCF18_RS16520	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CCF18_RS16525	COG3117	lipopolysaccharide transmembrane transporter activity
CCF18_RS16530	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CCF18_RS16535	COG1137	ATPase activity
CCF18_RS16540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CCF18_RS16545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CCF18_RS16560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS16565	COG0515	serine threonine protein kinase
CCF18_RS16575	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CCF18_RS16580	COG0784	Response regulator, receiver
CCF18_RS16580	COG2198	Histidine kinase
CCF18_RS16580	COG5002	protein histidine kinase activity
CCF18_RS16585	COG1242	4 iron, 4 sulfur cluster binding
CCF18_RS16590	COG0069	glutamate synthase activity
CCF18_RS16590	COG0067	glutamate synthase
CCF18_RS16590	COG0070	glutamate synthase
CCF18_RS16595	COG0493	'glutamate synthase
CCF18_RS16600	COG4804	nuclease activity
CCF18_RS16605	COG2731	YhcH YjgK YiaL family protein
CCF18_RS16635	COG2969	positive regulation of protein catabolic process
CCF18_RS16640	COG0625	glutathione transferase activity
CCF18_RS16660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CCF18_RS16665	COG3105	Protein conserved in bacteria
CCF18_RS16670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCF18_RS16675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCF18_RS16695	COG2732	(Barnase) inhibitor
CCF18_RS16715	COG0583	DNA-binding transcription factor activity
CCF18_RS16735	COG0471	metal ion transport
CCF18_RS16740	COG0312	modulator of DNA gyrase
CCF18_RS16745	COG3164	Protein of unknown function
CCF18_RS16750	COG1530	ribonuclease E activity
CCF18_RS16760	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CCF18_RS16765	COG1792	Involved in formation and maintenance of cell shape
CCF18_RS16770	COG1077	Cell shape determining protein MreB Mrl
CCF18_RS16780	COG2200	EAL domain
CCF18_RS16780	COG2199	diguanylate cyclase activity
CCF18_RS16785	COG0604	alcohol dehydrogenase
CCF18_RS16805	COG0511	ligase activity, forming carbon-carbon bonds
CCF18_RS16810	COG0439	Biotin carboxylase
CCF18_RS16815	COG3924	membrane
CCF18_RS16820	COG4145	pantothenate transmembrane transporter activity
CCF18_RS16830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CCF18_RS16840	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CCF18_RS16850	COG1309	transcriptional regulator
CCF18_RS16855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCF18_RS16905	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CCF18_RS16925	COG0551	DNA topoisomerase type I activity
CCF18_RS16955	COG0569	domain protein
CCF18_RS16965	COG3036	rescue of stalled ribosome
CCF18_RS16970	COG0789	Transcriptional regulator
CCF18_RS17010	COG0201	protein transport
CCF18_RS17100	COG0089	rRNA binding
CCF18_RS17175	COG2964	Protein conserved in bacteria
CCF18_RS17180	COG0545	Peptidyl-prolyl cis-trans isomerase
CCF18_RS17190	COG1047	Peptidyl-prolyl cis-trans
CCF18_RS17195	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CCF18_RS17210	COG0488	(ABC) transporter
CCF18_RS17215	COG0429	hydrolase of the alpha beta-hydrolase fold
CCF18_RS17225	COG3954	Phosphoribulokinase
CCF18_RS17230	COG1765	OsmC-like protein
CCF18_RS17235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CCF18_RS17240	COG1289	transmembrane transporter activity
CCF18_RS17245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CCF18_RS17250	COG0512	Glutamine amidotransferase of anthranilate synthase
CCF18_RS17255	COG2184	nucleotidyltransferase activity
CCF18_RS17265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CCF18_RS17275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CCF18_RS17280	COG2146	nitrite reductase [NAD(P)H] activity
CCF18_RS17285	COG2116	formate transmembrane transporter activity
CCF18_RS17300	COG0626	cystathionine gamma-synthase activity
CCF18_RS17315	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CCF18_RS17320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CCF18_RS17325	COG3457	Alanine racemase
CCF18_RS17335	COG2188	Transcriptional regulator
CCF18_RS17340	COG0180	Tryptophanyl-tRNA synthetase
CCF18_RS17350	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CCF18_RS17355	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CCF18_RS17360	COG3266	domain, Protein
CCF18_RS17375	COG4796	Type ii and iii secretion system protein
CCF18_RS17380	COG3166	PFAM Fimbrial assembly family protein
CCF18_RS17385	COG4972	Pilus assembly protein
CCF18_RS17390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CCF18_RS17395	COG0494	nUDIX hydrolase
CCF18_RS17405	COG1011	Hydrolase
CCF18_RS17410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CCF18_RS17470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CCF18_RS17475	COG2183	response to ionizing radiation
CCF18_RS17480	COG1918	ferrous iron import across plasma membrane
CCF18_RS17485	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CCF18_RS17495	COG5464	transposase or invertase
CCF18_RS17515	COG2610	gluconate transmembrane transporter activity
CCF18_RS17520	COG1640	4-alpha-glucanotransferase
CCF18_RS17525	COG0058	SHG alpha-glucan phosphorylase activity
CCF18_RS17540	COG1690	Belongs to the RtcB family
CCF18_RS17545	COG4650	regulator
CCF18_RS17550	COG1349	DNA-binding transcription factor activity
CCF18_RS17565	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CCF18_RS17600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CCF18_RS17605	COG0058	SHG alpha-glucan phosphorylase activity
CCF18_RS17630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CCF18_RS17635	COG2095	MarC family integral membrane protein
CCF18_RS17640	COG2610	gluconate transmembrane transporter activity
CCF18_RS17645	COG3265	gluconokinase activity
CCF18_RS17650	COG1609	Transcriptional regulator
CCF18_RS17655	COG1741	Belongs to the pirin family
CCF18_RS17660	COG0673	inositol 2-dehydrogenase activity
CCF18_RS17670	COG1247	-acetyltransferase
CCF18_RS17675	COG0405	Gamma-glutamyltransferase
CCF18_RS17685	COG0584	glycerophosphoryl diester phosphodiesterase
CCF18_RS17700	COG1175	transmembrane transport
CCF18_RS17720	COG0410	ABC transporter
CCF18_RS17725	COG0411	ABC transporter
CCF18_RS17730	COG4177	L-phenylalanine transmembrane transporter activity
CCF18_RS17735	COG0559	Belongs to the binding-protein-dependent transport system permease family
CCF18_RS17740	COG0683	leucine binding
CCF18_RS17745	COG0456	acetyltransferase
CCF18_RS17760	COG0683	leucine binding
CCF18_RS17790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CCF18_RS17795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CCF18_RS17800	COG2177	Part of the ABC transporter FtsEX involved in
CCF18_RS17805	COG2884	Cell division ATP-binding protein ftsE
CCF18_RS17810	COG0552	protein localization to endoplasmic reticulum
CCF18_RS17815	COG0742	ribosomal rna small subunit methyltransferase
CCF18_RS17820	COG3776	membrane
CCF18_RS17830	COG3714	YhhN family
CCF18_RS17850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CCF18_RS17860	COG0477	Major facilitator Superfamily
CCF18_RS17865	COG0628	permease
CCF18_RS17870	COG2091	lysine biosynthetic process via aminoadipic acid
CCF18_RS17875	COG0747	negative chemotaxis
CCF18_RS17880	COG0601	transmembrane transport
CCF18_RS17885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCF18_RS17905	COG2188	Transcriptional regulator
CCF18_RS17915	COG3414	Phosphotransferase system galactitol-specific IIB component
CCF18_RS17920	COG3775	system Galactitol-specific IIC component
CCF18_RS17935	COG0191	fructose-bisphosphate aldolase activity
CCF18_RS17940	COG0842	Transport permease protein
CCF18_RS17945	COG0842	Transport permease protein
CCF18_RS17945	COG1129	ABC transporter
CCF18_RS17950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCF18_RS17965	COG2081	HI0933 family
CCF18_RS17970	COG0306	phosphate transporter
CCF18_RS17980	COG0589	response to stress
CCF18_RS17990	COG3104	oligopeptide transport
CCF18_RS18000	COG2213	PTS system mannitol-specific
CCF18_RS18000	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS18010	COG1349	DNA-binding transcription factor activity
CCF18_RS18015	COG0246	Mannitol dehydrogenase
CCF18_RS18020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS18020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS18025	COG0371	Dehydrogenase
CCF18_RS18030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CCF18_RS18035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CCF18_RS18040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CCF18_RS18050	COG0339	signal peptide processing
CCF18_RS18055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CCF18_RS18060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCF18_RS18075	COG3549	Plasmid maintenance system killer
CCF18_RS18080	COG3093	addiction module antidote protein HigA
CCF18_RS18090	COG3065	identical protein binding
CCF18_RS18095	COG2197	response regulator
CCF18_RS18100	COG3720	iron ion transport
CCF18_RS18110	COG4558	Periplasmic binding protein
CCF18_RS18120	COG3721	Heme iron utilization protein
CCF18_RS18130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCF18_RS18150	COG3247	response to pH
CCF18_RS18155	COG2771	luxR family
CCF18_RS18165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCF18_RS18170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCF18_RS18180	COG2207	Transcriptional regulator
CCF18_RS18185	COG0076	glutamate decarboxylase activity
CCF18_RS18190	COG1858	cytochrome C peroxidase
CCF18_RS18200	COG2197	response regulator
CCF18_RS18205	COG0583	DNA-binding transcription factor activity
CCF18_RS18210	COG1295	ribonuclease BN
CCF18_RS18215	COG0477	Major facilitator Superfamily
CCF18_RS18220	COG2200	EAL domain
CCF18_RS18225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCF18_RS18230	COG0612	Peptidase, M16
CCF18_RS18240	COG2199	diguanylate cyclase activity
CCF18_RS18240	COG2200	EAL domain
CCF18_RS18245	COG0457	Tetratricopeptide repeat
CCF18_RS18245	COG3118	belongs to the thioredoxin family
CCF18_RS18250	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CCF18_RS18255	COG1215	transferase activity, transferring glycosyl groups
CCF18_RS18260	COG1215	transferase activity, transferring glycosyl groups
CCF18_RS18285	COG2194	sulfuric ester hydrolase activity
CCF18_RS18295	COG0814	amino acid
CCF18_RS18300	COG4608	Belongs to the ABC transporter superfamily
CCF18_RS18305	COG0444	Belongs to the ABC transporter superfamily
CCF18_RS18310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCF18_RS18315	COG0601	transmembrane transport
CCF18_RS18325	COG0747	negative chemotaxis
CCF18_RS18345	COG2194	sulfuric ester hydrolase activity
CCF18_RS18350	COG2223	nitrite transmembrane transporter activity
CCF18_RS18355	COG5571	outer membrane autotransporter
CCF18_RS18360	COG2818	Glycosylase
CCF18_RS18365	COG0456	acetyltransferase
CCF18_RS18370	COG0243	molybdopterin cofactor binding
CCF18_RS18375	COG2885	chlorophyll binding
CCF18_RS18390	COG2944	sequence-specific DNA binding
CCF18_RS18395	COG1278	Cold shock
CCF18_RS18420	COG3274	enterobacterial common antigen metabolic process
CCF18_RS18425	COG4682	membrane
CCF18_RS18430	COG2992	FlgJ-related protein
CCF18_RS18435	COG3977	Valine--pyruvate aminotransferase
CCF18_RS18440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCF18_RS18445	COG1414	Transcriptional regulator
CCF18_RS18455	COG2731	YhcH YjgK YiaL family protein
CCF18_RS18465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CCF18_RS18470	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CCF18_RS18475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CCF18_RS18480	COG1070	Carbohydrate kinase
CCF18_RS18485	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CCF18_RS18490	COG3623	hexulose-6-phosphate isomerase
CCF18_RS18495	COG0235	Class ii aldolase
CCF18_RS18500	COG1012	belongs to the aldehyde dehydrogenase family
CCF18_RS18510	COG1454	alcohol dehydrogenase
CCF18_RS18515	COG3276	selenocysteine insertion sequence binding
CCF18_RS18525	COG0625	glutathione transferase activity
CCF18_RS18530	COG2258	MOSC domain
CCF18_RS18535	COG1566	PFAM secretion protein HlyD family protein
CCF18_RS18545	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS18545	COG2213	PTS system mannitol-specific
CCF18_RS18555	COG3722	fumarate hydratase activity
CCF18_RS18575	COG5295	Hep Hag repeat protein
CCF18_RS18580	COG1620	l-lactate permease
CCF18_RS18585	COG2186	Transcriptional regulator
CCF18_RS18595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CCF18_RS18600	COG1045	serine acetyltransferase
CCF18_RS18615	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CCF18_RS18620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CCF18_RS18630	COG4942	peptidase
CCF18_RS18635	COG2861	carbohydrate metabolic process
CCF18_RS18640	COG1216	Glycosyl transferase, family 2
CCF18_RS18650	COG0156	8-amino-7-oxononanoate synthase activity
CCF18_RS18660	COG0859	PFAM glycosyl transferase family 9
CCF18_RS18665	COG0859	PFAM glycosyl transferase family 9
CCF18_RS18685	COG3642	lipopolysaccharide core region biosynthetic process
CCF18_RS18690	COG1442	glycosyl transferase family 8
CCF18_RS18695	COG1442	glycosyl transferase family 8
CCF18_RS18700	COG0438	transferase activity, transferring glycosyl groups
CCF18_RS18705	COG0859	PFAM glycosyl transferase family 9
CCF18_RS18710	COG0515	serine threonine protein kinase
CCF18_RS18715	COG0438	transferase activity, transferring glycosyl groups
CCF18_RS18720	COG0859	PFAM glycosyl transferase family 9
CCF18_RS18725	COG1519	Transferase
CCF18_RS18755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CCF18_RS18780	COG1561	YicC-like family, N-terminal region
CCF18_RS18785	COG3710	Transcriptional regulator
CCF18_RS18790	COG0531	amino acid
CCF18_RS18795	COG1982	Orn Lys Arg decarboxylase major
CCF18_RS18800	COG3104	oligopeptide transport
CCF18_RS18805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CCF18_RS18810	COG2860	membrane
CCF18_RS18820	COG0194	GDP metabolic process
CCF18_RS18830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CCF18_RS18835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CCF18_RS18840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CCF18_RS18845	COG0786	glutamate:sodium symporter activity
CCF18_RS18850	COG2233	PERMEase
CCF18_RS18855	COG2982	Protein involved in outer membrane biogenesis
CCF18_RS18865	COG0582	viral genome integration into host DNA
CCF18_RS18925	COG0582	viral genome integration into host DNA
CCF18_RS18940	COG2814	Major facilitator Superfamily
CCF18_RS18950	COG0697	spore germination
CCF18_RS18960	COG0457	Tetratricopeptide repeat
CCF18_RS18990	COG1470	cell adhesion involved in biofilm formation
CCF18_RS18990	COG1388	LysM domain
CCF18_RS19000	COG2252	PERMEase
CCF18_RS19010	COG2271	Major facilitator Superfamily
CCF18_RS19015	COG2271	Major facilitator Superfamily
CCF18_RS19020	COG3851	Histidine kinase
CCF18_RS19025	COG2197	response regulator
CCF18_RS19030	COG0440	acetolactate synthase activity
CCF18_RS19035	COG0028	Belongs to the TPP enzyme family
CCF18_RS19045	COG2814	Major facilitator Superfamily
CCF18_RS19050	COG0641	radical SAM
CCF18_RS19060	COG2149	membrane
CCF18_RS19070	COG3119	arylsulfatase activity
CCF18_RS19075	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CCF18_RS19080	COG2207	Transcriptional regulator
CCF18_RS19100	COG5645	(Lipo)protein
CCF18_RS19105	COG0823	Involved in the tonB-independent uptake of proteins
CCF18_RS19120	COG0561	phosphatase activity
CCF18_RS19125	COG3753	Protein conserved in bacteria
CCF18_RS19130	COG0187	DNA topoisomerase II activity
CCF18_RS19140	COG0592	DNA-directed DNA polymerase activity
CCF18_RS19190	COG0814	amino acid
CCF18_RS19205	COG2091	lysine biosynthetic process via aminoadipic acid
CCF18_RS19210	COG0431	NADPH-dependent FMN reductase
CCF18_RS19215	COG2252	PERMEase
CCF18_RS19220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CCF18_RS19225	COG3196	Protein conserved in bacteria
CCF18_RS19230	COG0704	Plays a role in the regulation of phosphate uptake
CCF18_RS19235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CCF18_RS19240	COG0581	inorganic phosphate transmembrane transporter activity
CCF18_RS19245	COG0573	inorganic phosphate transmembrane transporter activity
CCF18_RS19250	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CCF18_RS19295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CCF18_RS19310	COG3312	ion transport
CCF18_RS19330	COG0716	FMN binding
CCF18_RS19335	COG1522	sequence-specific DNA binding
CCF18_RS19365	COG1129	ABC transporter
CCF18_RS19370	COG1172	Belongs to the binding-protein-dependent transport system permease family
CCF18_RS19375	COG1879	ABC-type sugar transport system periplasmic component
CCF18_RS19380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCF18_RS19385	COG1609	Transcriptional regulator
CCF18_RS19390	COG0477	Major facilitator Superfamily
CCF18_RS19395	COG2186	Transcriptional regulator
CCF18_RS19440	COG3085	chromosome segregation
CCF18_RS19445	COG0606	chelatase, subunit chli
CCF18_RS19465	COG3978	acetolactate synthase activity
CCF18_RS19470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CCF18_RS19480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CCF18_RS19525	COG0583	DNA-binding transcription factor activity
CCF18_RS19535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCF18_RS19540	COG0210	DNA helicase
CCF18_RS19555	COG3118	belongs to the thioredoxin family
CCF18_RS19565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CCF18_RS19570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CCF18_RS19575	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
CCF18_RS19580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CCF18_RS19585	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CCF18_RS19590	COG1088	dTDP-glucose 4,6-dehydratase activity
CCF18_RS19595	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CCF18_RS19600	COG0456	acetyltransferase
CCF18_RS19605	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CCF18_RS19610	COG2244	polysaccharide biosynthetic process
CCF18_RS19630	COG1113	amino acid transport
CCF18_RS19655	COG0641	radical SAM
CCF18_RS19660	COG3119	arylsulfatase activity
CCF18_RS19670	COG3071	HemY protein
CCF18_RS19675	COG2959	enzyme of heme biosynthesis
CCF18_RS19680	COG1587	Uroporphyrinogen-III synthase
CCF18_RS19690	COG3072	Adenylate cyclase
CCF18_RS19715	COG5567	small periplasmic lipoprotein
CCF18_RS19725	COG3159	Protein conserved in bacteria
CCF18_RS19735	COG1011	Hydrolase
CCF18_RS19740	COG0210	DNA helicase
CCF18_RS19745	COG3698	Phosphodiester glycosidase
CCF18_RS19750	COG0598	Magnesium transport protein CorA
CCF18_RS19765	COG2962	Rard protein
CCF18_RS19770	COG2050	protein possibly involved in aromatic compounds catabolism
CCF18_RS19775	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CCF18_RS19780	COG0514	ATP-dependent DNA helicase (RecQ)
CCF18_RS19785	COG1280	lysine exporter protein (LysE YggA)
CCF18_RS19795	COG2267	carboxylic ester hydrolase activity
CCF18_RS19800	COG0561	phosphatase activity
CCF18_RS19805	COG0697	spore germination
CCF18_RS19810	COG0583	DNA-binding transcription factor activity
CCF18_RS19820	COG0412	Dienelactone hydrolase
CCF18_RS19825	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CCF18_RS19830	COG1322	Protein conserved in bacteria
CCF18_RS19840	COG3165	ubiquinone biosynthetic process from chorismate
CCF18_RS19850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CCF18_RS19860	COG0805	protein transport
CCF18_RS19880	COG0543	2 iron, 2 sulfur cluster binding
CCF18_RS19900	COG1739	Uncharacterized protein family UPF0029
CCF18_RS19905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CCF18_RS19910	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CCF18_RS19935	COG1763	Mo-molybdopterin cofactor biosynthetic process
CCF18_RS19940	COG0746	molybdenum cofactor guanylyltransferase activity
CCF18_RS19945	COG3084	Protein conserved in bacteria
CCF18_RS19950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CCF18_RS19955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CCF18_RS19960	COG5339	Protein conserved in bacteria
CCF18_RS19965	COG0204	Acyl-transferase
CCF18_RS19975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CCF18_RS19975	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CCF18_RS19990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CCF18_RS20000	COG2204	response regulator
CCF18_RS20005	COG3852	Histidine kinase
CCF18_RS20010	COG0174	glutamine synthetase
CCF18_RS20015	COG1217	gtp-binding protein TYPA
CCF18_RS20020	COG2188	Transcriptional regulator
CCF18_RS20025	COG1082	Xylose isomerase domain protein TIM barrel
CCF18_RS20030	COG2271	Major facilitator Superfamily
CCF18_RS20035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CCF18_RS20040	COG2211	Major facilitator Superfamily
CCF18_RS20045	COG2211	Major facilitator Superfamily
CCF18_RS20050	COG1501	Belongs to the glycosyl hydrolase 31 family
CCF18_RS20060	COG2017	converts alpha-aldose to the beta-anomer
CCF18_RS20065	COG2942	2-epimerase
CCF18_RS20070	COG3684	Belongs to the aldolase LacD family
CCF18_RS20075	COG2084	Dehydrogenase
CCF18_RS20080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CCF18_RS20085	COG1349	DNA-binding transcription factor activity
CCF18_RS20090	COG1011	Hydrolase
CCF18_RS20105	COG0456	acetyltransferase
CCF18_RS20110	COG0657	acetylesterase activity
CCF18_RS20115	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
CCF18_RS20135	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CCF18_RS20155	COG2864	formate dehydrogenase
CCF18_RS20160	COG0437	4 iron, 4 sulfur cluster binding
CCF18_RS20185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CCF18_RS20190	COG2258	MOSC domain
CCF18_RS20195	COG2205	protein histidine kinase activity
CCF18_RS20200	COG0745	RESPONSE REGULATOR receiver
CCF18_RS20205	COG3678	ATP-independent chaperone mediated protein folding
CCF18_RS20210	COG4974	Belongs to the 'phage' integrase family
CCF18_RS20260	COG4695	Portal protein
CCF18_RS20355	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CCF18_RS20370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CCF18_RS20425	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CCF18_RS20435	COG2390	Transcriptional regulator
CCF18_RS20445	COG1070	Carbohydrate kinase
CCF18_RS20450	COG1172	Belongs to the binding-protein-dependent transport system permease family
CCF18_RS20455	COG1879	ABC-type sugar transport system periplasmic component
CCF18_RS20465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CCF18_RS20480	COG3152	Membrane
CCF18_RS20485	COG3691	Protein conserved in bacteria
CCF18_RS20490	COG0589	response to stress
CCF18_RS20500	COG1494	fructose-1,6-bisphosphatase
CCF18_RS20510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CCF18_RS20530	COG1575	Belongs to the MenA family. Type 1 subfamily
CCF18_RS20545	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CCF18_RS20550	COG1609	Transcriptional regulator
CCF18_RS20555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CCF18_RS20565	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CCF18_RS20575	COG0626	cystathionine gamma-synthase activity
CCF18_RS20580	COG0527	aspartate kinase activity
CCF18_RS20580	COG0460	homoserine dehydrogenase
CCF18_RS20590	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CCF18_RS20600	COG0697	spore germination
CCF18_RS20605	COG3738	Protein conserved in bacteria
CCF18_RS20615	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CCF18_RS20620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCF18_RS20620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS20620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS20625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCF18_RS20630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCF18_RS20635	COG1882	Formate acetyltransferase
CCF18_RS20640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CCF18_RS20645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CCF18_RS20650	COG2207	Transcriptional regulator
CCF18_RS20655	COG2194	sulfuric ester hydrolase activity
CCF18_RS20670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CCF18_RS20685	COG0583	DNA-binding transcription factor activity
CCF18_RS20695	COG1473	amidohydrolase
CCF18_RS20700	COG0477	Major facilitator Superfamily
CCF18_RS20705	COG1309	transcriptional regulator
CCF18_RS20750	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CCF18_RS20755	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CCF18_RS20755	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CCF18_RS20790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CCF18_RS20795	COG0250	Participates in transcription elongation, termination and antitermination
CCF18_RS20840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CCF18_RS20850	COG2104	thiamine diphosphate biosynthetic process
CCF18_RS20855	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CCF18_RS20890	COG3068	Protein conserved in bacteria
CCF18_RS20905	COG3678	ATP-independent chaperone mediated protein folding
CCF18_RS20910	COG4191	Histidine kinase
CCF18_RS20915	COG2204	response regulator
CCF18_RS20920	COG0151	Belongs to the GarS family
CCF18_RS20950	COG0456	acetyltransferase
CCF18_RS20960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CCF18_RS20965	COG2224	Isocitrate lyase
CCF18_RS20975	COG1414	Transcriptional regulator
CCF18_RS20980	COG0646	methionine synthase
CCF18_RS20980	COG1410	methionine synthase
CCF18_RS20985	COG1283	sodium-dependent phosphate transmembrane transporter activity
CCF18_RS21035	COG1187	pseudouridine synthase activity
CCF18_RS21065	COG5301	cellulose 1,4-beta-cellobiosidase activity
CCF18_RS21145	COG0741	lytic transglycosylase activity
CCF18_RS21160	COG0527	aspartate kinase activity
CCF18_RS21195	COG3833	ABC-type maltose transport systems, permease component
CCF18_RS21200	COG1175	transmembrane transport
CCF18_RS21205	COG2182	Extracellular solute-binding protein
CCF18_RS21210	COG3842	ATPase activity
CCF18_RS21240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CCF18_RS21250	COG0534	Mate efflux family protein
CCF18_RS21255	COG3237	CsbD-like
CCF18_RS21260	COG0735	belongs to the Fur family
CCF18_RS21265	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CCF18_RS21275	COG0604	alcohol dehydrogenase
CCF18_RS21280	COG0305	Participates in initiation and elongation during chromosome replication
CCF18_RS21290	COG1448	Aminotransferase
CCF18_RS21295	COG0567	Dehydrogenase, E1 component
CCF18_RS21305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCF18_RS21310	COG0045	succinate-CoA ligase (ADP-forming) activity
CCF18_RS21315	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CCF18_RS21320	COG0471	metal ion transport
CCF18_RS21325	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CCF18_RS21330	COG2204	response regulator
CCF18_RS21340	COG3700	Belongs to the class B bacterial acid phosphatase family
CCF18_RS21345	COG0432	Pfam Uncharacterised protein family UPF0047
CCF18_RS21350	COG2315	Protein conserved in bacteria
CCF18_RS21355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CCF18_RS21360	COG0629	single-stranded DNA binding
CCF18_RS21370	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CCF18_RS21375	COG2207	Transcriptional regulator
CCF18_RS21380	COG0789	Transcriptional regulator
CCF18_RS21385	COG2252	PERMEase
CCF18_RS21390	COG0025	NhaP-type Na H and K H
CCF18_RS21400	COG3162	membrane
CCF18_RS21405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CCF18_RS21420	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CCF18_RS21425	COG0437	4 iron, 4 sulfur cluster binding
CCF18_RS21430	COG3301	Polysulphide reductase, NrfD
CCF18_RS21435	COG1138	Cytochrome C-type biogenesis protein
CCF18_RS21440	COG3088	subunit of a heme lyase
CCF18_RS21445	COG4235	cytochrome complex assembly
CCF18_RS21450	COG1301	dicarboxylic acid transport
CCF18_RS21455	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CCF18_RS21460	COG4608	Belongs to the ABC transporter superfamily
CCF18_RS21465	COG0444	Belongs to the ABC transporter superfamily
CCF18_RS21470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CCF18_RS21475	COG0601	transmembrane transport
CCF18_RS21495	COG1289	transmembrane transporter activity
CCF18_RS21500	COG1566	PFAM secretion protein HlyD family protein
CCF18_RS21510	COG2015	COG2015, Alkyl sulfatase and related hydrolases
CCF18_RS21520	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CCF18_RS21525	COG2824	Alkylphosphonate utilization operon protein PhnA
CCF18_RS21545	COG0642	Histidine kinase
CCF18_RS21550	COG0745	RESPONSE REGULATOR receiver
CCF18_RS21555	COG2194	sulfuric ester hydrolase activity
CCF18_RS21560	COG0531	amino acid
CCF18_RS21565	COG2207	Transcriptional regulator
CCF18_RS21570	COG1982	Orn Lys Arg decarboxylase major
CCF18_RS21575	COG3647	Membrane
CCF18_RS21580	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CCF18_RS21580	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CCF18_RS21585	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CCF18_RS21595	COG4565	transcriptional regulatory protein
CCF18_RS21600	COG3290	protein histidine kinase activity
CCF18_RS21605	COG3592	Divergent 4Fe-4S mono-cluster
CCF18_RS21610	COG2388	GCN5-related N-acetyl-transferase
CCF18_RS21850	COG1309	transcriptional regulator
CCF18_RS21855	COG4232	protein-disulfide reductase activity
CCF18_RS21865	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CCF18_RS21870	COG1027	Aspartate ammonia-lyase
CCF18_RS21875	COG3030	protein affecting phage T7 exclusion by the F plasmid
CCF18_RS21880	COG0531	amino acid
CCF18_RS21905	COG1509	lysine 2,3-aminomutase activity
CCF18_RS21915	COG5510	response to toxic substance
CCF18_RS21930	COG2076	Multidrug Resistance protein
CCF18_RS21935	COG3040	lipid binding
CCF18_RS21940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CCF18_RS21955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CCF18_RS21960	COG1053	succinate dehydrogenase
CCF18_RS21970	COG0531	amino acid
CCF18_RS21985	COG1511	domain protein
CCF18_RS21985	COG3264	Mechanosensitive ion channel
CCF18_RS22020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CCF18_RS22025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CCF18_RS22025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CCF18_RS22030	COG0802	atpase or kinase
CCF18_RS22035	COG0860	N-Acetylmuramoyl-L-alanine amidase
CCF18_RS22040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CCF18_RS22055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CCF18_RS22060	COG0330	HflC and HflK could
CCF18_RS22065	COG0330	HflC and HflK could
CCF18_RS22070	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CCF18_RS22085	COG0557	exoribonuclease II activity
CCF18_RS22090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CCF18_RS22095	COG0754	glutathionylspermidine amidase activity
CCF18_RS22100	COG1960	acyl-CoA dehydrogenase activity
CCF18_RS22110	COG3650	response to hydrogen peroxide
CCF18_RS22115	COG1073	alpha beta
CCF18_RS22130	COG3037	sugar-specific permease SgaT UlaA
CCF18_RS22135	COG3414	Phosphotransferase system galactitol-specific IIB component
CCF18_RS22140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS22175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CCF18_RS22200	COG2030	dehydratase
CCF18_RS22205	COG2271	Major facilitator Superfamily
CCF18_RS22210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CCF18_RS22215	COG4670	ketone body catabolic process
CCF18_RS22230	COG1309	transcriptional regulator
CCF18_RS22235	COG3061	Opacity-associated protein A
CCF18_RS22240	COG0545	Peptidyl-prolyl cis-trans isomerase
CCF18_RS22245	COG1113	amino acid transport
CCF18_RS22265	COG0697	spore germination
CCF18_RS22270	COG1733	regulation of RNA biosynthetic process
CCF18_RS22275	COG0737	Belongs to the 5'-nucleotidase family
CCF18_RS22280	COG1218	3'(2'),5'-bisphosphate nucleotidase
CCF18_RS22290	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CCF18_RS22300	COG1253	flavin adenine dinucleotide binding
CCF18_RS22310	COG0729	surface antigen
CCF18_RS22315	COG2911	Protein conserved in bacteria
CCF18_RS22320	COG2105	PFAM AIG2 family protein
CCF18_RS22325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CCF18_RS22330	COG1879	ABC-type sugar transport system periplasmic component
CCF18_RS22335	COG1129	ABC transporter
CCF18_RS22340	COG1172	Belongs to the binding-protein-dependent transport system permease family
CCF18_RS22345	COG1172	Belongs to the binding-protein-dependent transport system permease family
CCF18_RS22360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CCF18_RS22370	COG0312	modulator of DNA gyrase
CCF18_RS22375	COG3783	Cytochrome b(562)
CCF18_RS22390	COG0602	queuosine metabolic process
CCF18_RS22395	COG1328	CTP reductase activity
CCF18_RS22400	COG0366	Alpha amylase catalytic
CCF18_RS22405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CCF18_RS22405	COG1263	PTS System
CCF18_RS22410	COG1609	Transcriptional regulator
CCF18_RS22420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CCF18_RS22430	COG0251	oxidation-reduction process
CCF18_RS22450	COG2731	YhcH YjgK YiaL family protein
CCF18_RS22470	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
CCF18_RS22475	COG0456	acetyltransferase
CCF18_RS22485	COG0525	valine-tRNA ligase activity
CCF18_RS22490	COG2927	DNA polymerase III (CHI subunit)
CCF18_RS22500	COG0795	lipopolysaccharide-transporting ATPase activity
CCF18_RS22505	COG0795	lipopolysaccharide-transporting ATPase activity
CCF18_RS22510	COG0433	COG0433 Predicted ATPase
CCF18_RS22515	COG1064	alcohol dehydrogenase
CCF18_RS22540	COG2815	serine threonine protein kinase
CCF18_RS22540	COG0515	serine threonine protein kinase
CCF18_RS22665	COG0582	viral genome integration into host DNA
CCF18_RS22670	COG4974	Belongs to the 'phage' integrase family
CCF18_RS22680	COG3539	Fimbrial protein
CCF18_RS22685	COG3121	Chaperone
CCF18_RS22690	COG3188	usher protein
CCF18_RS22695	COG3539	Fimbrial protein
CCF18_RS22700	COG3539	Fimbrial protein
CCF18_RS22705	COG3539	Fimbrial protein
CCF18_RS22710	COG2610	gluconate transmembrane transporter activity
CCF18_RS22720	COG0246	Mannitol dehydrogenase
CCF18_RS22725	COG2186	Transcriptional regulator
CCF18_RS22740	COG3518	anti-sigma factor antagonist activity
CCF18_RS22745	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS22745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CCF18_RS22750	COG1461	Dihydroxyacetone kinase
CCF18_RS22755	COG2376	Dihydroxyacetone kinase
CCF18_RS22770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCF18_RS22785	COG1929	Belongs to the glycerate kinase type-1 family
CCF18_RS22790	COG2084	Dehydrogenase
CCF18_RS22795	COG3622	Belongs to the hyi family
CCF18_RS22800	COG3960	tartronate-semialdehyde synthase activity
CCF18_RS22805	COG3284	Transcriptional regulator
CCF18_RS22815	COG1757	Na H antiporter
CCF18_RS22820	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CCF18_RS22825	COG0700	Nucleoside recognition
CCF18_RS22830	COG3366	ferrous iron transmembrane transporter activity
CCF18_RS22845	COG1924	4 iron, 4 sulfur cluster binding
CCF18_RS22850	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CCF18_RS22855	COG2733	membrane
CCF18_RS22870	COG4268	DNA restriction-modification system
CCF18_RS22875	COG1401	restriction endodeoxyribonuclease activity
CCF18_RS22885	COG0732	type I restriction modification DNA specificity domain
CCF18_RS22890	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CCF18_RS22895	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CCF18_RS22905	COG0523	cobalamin synthesis protein
CCF18_RS22910	COG2879	small protein
CCF18_RS22915	COG1966	Carbon starvation protein
CCF18_RS22925	COG0840	transmembrane signaling receptor activity
CCF18_RS22930	COG2271	Major facilitator Superfamily
CCF18_RS22935	COG1802	Transcriptional regulator
CCF18_RS22940	COG1063	alcohol dehydrogenase
CCF18_RS22955	COG1484	DNA-dependent DNA replication
CCF18_RS22970	COG2966	Psort location CytoplasmicMembrane, score
CCF18_RS22975	COG2197	response regulator
CCF18_RS22980	COG2197	response regulator
CCF18_RS22985	COG4114	ferric iron reductase
CCF18_RS23015	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
CCF18_RS23020	COG0456	acetyltransferase
CCF18_RS23025	COG1011	Hydrolase
CCF18_RS23040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CCF18_RS23050	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CCF18_RS23055	COG5532	Uncharacterized conserved protein (DUF2303)
CCF18_RS23090	COG1846	Transcriptional regulator
CCF18_RS23100	COG4725	Belongs to the MT-A70-like family
CCF18_RS23105	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CCF18_RS23115	COG1403	HNH endonuclease
CCF18_RS23130	COG3272	Protein of unknown function (DUF1722)
CCF18_RS23140	COG2207	Transcriptional regulator
CCF18_RS23150	COG3772	lysozyme
CCF18_RS23190	COG0740	serine-type endopeptidase activity
CCF18_RS23265	COG5301	cellulose 1,4-beta-cellobiosidase activity
CCF18_RS23270	COG0727	PFAM Uncharacterised protein family (UPF0153)
CCF18_RS23305	COG2823	Periplasmic or secreted lipoprotein
CCF18_RS23315	COG4667	esterase of the alpha-beta hydrolase superfamily
CCF18_RS23320	COG0084	hydrolase, TatD family'
CCF18_RS23325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CCF18_RS23330	COG1328	CTP reductase activity
CCF18_RS23355	COG0095	Lipoate-protein ligase
CCF18_RS23360	COG3726	membrane protein affecting hemolysin expression
CCF18_RS23365	COG0560	Phosphoserine phosphatase
CCF18_RS23370	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CCF18_RS23375	COG3172	ATPase kinase involved in NAD metabolism
CCF18_RS23375	COG1056	cytidyltransferase-related domain
CCF18_RS23380	COG0488	(ABC) transporter
CCF18_RS23385	COG0741	lytic transglycosylase activity
CCF18_RS23405	COG2207	Transcriptional regulator
CCF18_RS23405	COG3708	Transcriptional regulator
CCF18_RS23410	COG3045	CreA protein
CCF18_RS23415	COG0745	RESPONSE REGULATOR receiver
CCF18_RS23420	COG2205	protein histidine kinase activity
CCF18_RS23425	COG4452	Inner membrane protein CreD
CCF18_RS23430	COG0745	RESPONSE REGULATOR receiver
CCF18_RS23440	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CCF18_RS23450	COG0460	homoserine dehydrogenase
CCF18_RS23450	COG0527	aspartate kinase activity
CCF18_RS23460	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CCF18_RS23485	COG0521	Mo-molybdopterin cofactor biosynthetic process
CCF18_RS23490	COG1584	GPR1 FUN34 yaaH family protein
CCF18_RS23495	COG4735	regulation of single-species biofilm formation
CCF18_RS23525	COG3119	arylsulfatase activity
CCF18_RS23535	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CCF18_RS23540	COG0583	DNA-binding transcription factor activity
CCF18_RS23565	COG0196	riboflavin kinase activity
CCF18_RS23580	COG1047	Peptidyl-prolyl cis-trans
CCF18_RS23610	COG0505	Belongs to the CarA family
CCF18_RS23615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CCF18_RS23665	COG0644	oxidoreductase
CCF18_RS23670	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
CCF18_RS23675	COG2271	Major facilitator Superfamily
CCF18_RS23685	COG0475	glutathione-regulated potassium exporter activity
CCF18_RS23685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CCF18_RS23690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CCF18_RS23730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCF18_RS23740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CCF18_RS23745	COG0564	pseudouridine synthase activity
CCF18_RS23755	COG0417	DNA replication proofreading
CCF18_RS23780	COG0235	Class ii aldolase
CCF18_RS23795	COG4977	sequence-specific DNA binding
CCF18_RS23800	COG0586	Pfam SNARE associated Golgi protein
CCF18_RS23810	COG1178	ABC-type Fe3 transport system permease component
CCF18_RS23815	COG4143	(ABC) transporter
CCF18_RS23855	COG0583	DNA-binding transcription factor activity
CCF18_RS23860	COG0028	Belongs to the TPP enzyme family
CCF18_RS23865	COG0440	acetolactate synthase activity
CCF18_RS23875	COG1609	Transcriptional regulator
CCF18_RS23890	COG3116	cell division
CCF18_RS23895	COG0768	penicillin binding
CCF18_RS23900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CCF18_RS23905	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CCF18_RS23920	COG0772	Belongs to the SEDS family
CCF18_RS23935	COG1181	Belongs to the D-alanine--D-alanine ligase family
CCF18_RS23940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CCF18_RS23945	COG0849	cell division
CCF18_RS23950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CCF18_RS23970	COG0494	nUDIX hydrolase
CCF18_RS23985	COG0237	dephospho-CoA kinase activity
CCF18_RS23995	COG1459	type II secretion system
CCF18_RS24000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CCF18_RS24005	COG4969	Belongs to the N-Me-Phe pilin family
CCF18_RS24010	COG0157	Belongs to the NadC ModD family
CCF18_RS24015	COG3023	N-Acetylmuramoyl-L-alanine amidase
CCF18_RS24020	COG3725	Membrane protein required for beta-lactamase induction
CCF18_RS24025	COG1113	amino acid transport
CCF18_RS24030	COG2186	Transcriptional regulator
CCF18_RS24035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CCF18_RS24040	COG0508	dehydrogenase complex catalyzes the overall conversion of
CCF18_RS24045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCF18_RS24055	COG3064	Membrane
CCF18_RS24060	COG1049	propionate catabolic process, 2-methylcitrate cycle
CCF18_RS24095	COG2132	Multicopper oxidase
CCF18_RS24110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CCF18_RS24115	COG0288	reversible hydration of carbon dioxide
CCF18_RS24120	COG1131	(ABC) transporter
CCF18_RS24125	COG0842	Transport permease protein
CCF18_RS24130	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CCF18_RS24135	COG0726	polysaccharide deacetylase
CCF18_RS24145	COG5464	transposase or invertase
CCF18_RS24165	COG3539	Fimbrial protein
CCF18_RS24170	COG3539	Fimbrial protein
CCF18_RS24175	COG3539	Fimbrial protein
CCF18_RS24180	COG3188	usher protein
CCF18_RS24185	COG3121	Chaperone
CCF18_RS24195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CCF18_RS24200	COG0617	tRNA 3'-terminal CCA addition
CCF18_RS24210	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CCF18_RS24220	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CCF18_RS24225	COG1643	Atp-dependent helicase
CCF18_RS24230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CCF18_RS24235	COG3853	Toxic anion resistance protein (TelA)
CCF18_RS24245	COG4774	siderophore transport
CCF18_RS24250	COG1120	ATPase activity
CCF18_RS24255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CCF18_RS24260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CCF18_RS24285	COG2860	membrane
CCF18_RS24290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CCF18_RS24305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCF18_RS24310	COG3835	regulator
CCF18_RS24320	COG1408	metallophosphoesterase
CCF18_RS24335	COG0024	Methionine aminopeptidase
CCF18_RS24360	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CCF18_RS24365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CCF18_RS24370	COG0575	Belongs to the CDS family
CCF18_RS24375	COG0750	zinc metalloprotease
CCF18_RS24385	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CCF18_RS24390	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCF18_RS24415	COG0587	DNA-directed DNA polymerase activity
CCF18_RS24430	COG0346	lactoylglutathione lyase activity
CCF18_RS24460	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CCF18_RS24470	COG1525	nuclease
CCF18_RS24580	COG3710	Transcriptional regulator
CCF18_RS24585	COG0726	polysaccharide deacetylase
CCF18_RS24605	COG3969	phosphoadenosine phosphosulfate
CCF18_RS24610	COG1475	DNA binding
CCF18_RS24640	COG4591	ABC-type transport system involved in lipoprotein release permease component
CCF18_RS24725	COG2990	Protein conserved in bacteria
CCF18_RS24730	COG1560	Kdo2-lipid A biosynthetic process
CCF18_RS24735	COG0297	glycogen (starch) synthase activity
CCF18_RS24740	COG0726	polysaccharide deacetylase
CCF18_RS24760	COG2200	EAL domain
CCF18_RS24760	COG2771	luxR family
CCF18_RS24775	COG4932	domain protein
CCF18_RS24775	COG1388	LysM domain
CCF18_RS24775	COG2373	Large extracellular alpha-helical protein
CCF18_RS24830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity