locus-tag	class	description
SR35_RS00010	COG0527	aspartate kinase activity
SR35_RS00010	COG0460	homoserine dehydrogenase
SR35_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SR35_RS00040	COG1115	amino acid carrier protein
SR35_RS00050	COG0521	Mo-molybdopterin cofactor biosynthetic process
SR35_RS00055	COG1584	GPR1 FUN34 yaaH family protein
SR35_RS00060	COG4735	regulation of single-species biofilm formation
SR35_RS00080	COG3385	transposase activity
SR35_RS00095	COG0583	DNA-binding transcription factor activity
SR35_RS00105	COG3188	usher protein
SR35_RS00140	COG0196	riboflavin kinase activity
SR35_RS00155	COG1047	Peptidyl-prolyl cis-trans
SR35_RS00185	COG0505	Belongs to the CarA family
SR35_RS00190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SR35_RS00245	COG0644	oxidoreductase
SR35_RS00250	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
SR35_RS00255	COG2271	Major facilitator Superfamily
SR35_RS00270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SR35_RS00295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SR35_RS00300	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SR35_RS00305	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
SR35_RS00315	COG0564	pseudouridine synthase activity
SR35_RS00325	COG0417	DNA replication proofreading
SR35_RS00330	COG0235	Class ii aldolase
SR35_RS00335	COG2160	L-arabinose isomerase activity
SR35_RS00340	COG1069	ribulokinase activity
SR35_RS00345	COG4977	sequence-specific DNA binding
SR35_RS00350	COG0586	Pfam SNARE associated Golgi protein
SR35_RS00355	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
SR35_RS00360	COG1178	ABC-type Fe3 transport system permease component
SR35_RS00365	COG4143	(ABC) transporter
SR35_RS00370	COG4533	DNA binding
SR35_RS00380	COG2814	Major facilitator Superfamily
SR35_RS00395	COG0473	3-isopropylmalate dehydrogenase activity
SR35_RS00410	COG0583	DNA-binding transcription factor activity
SR35_RS00415	COG0028	Belongs to the TPP enzyme family
SR35_RS00420	COG0440	acetolactate synthase activity
SR35_RS00430	COG1609	Transcriptional regulator
SR35_RS00435	COG2001	Belongs to the MraZ family
SR35_RS00445	COG3116	cell division
SR35_RS00450	COG0768	penicillin binding
SR35_RS00455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SR35_RS00460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SR35_RS00470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SR35_RS00475	COG0772	Belongs to the SEDS family
SR35_RS00490	COG1181	Belongs to the D-alanine--D-alanine ligase family
SR35_RS00495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SR35_RS00500	COG0849	cell division
SR35_RS00505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SR35_RS00525	COG0494	nUDIX hydrolase
SR35_RS00545	COG0237	dephospho-CoA kinase activity
SR35_RS00555	COG1459	type II secretion system
SR35_RS00560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SR35_RS00565	COG4969	Belongs to the N-Me-Phe pilin family
SR35_RS00575	COG0157	Belongs to the NadC ModD family
SR35_RS00580	COG3023	N-Acetylmuramoyl-L-alanine amidase
SR35_RS00585	COG3725	Membrane protein required for beta-lactamase induction
SR35_RS00590	COG1113	amino acid transport
SR35_RS00595	COG2186	Transcriptional regulator
SR35_RS00600	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SR35_RS00605	COG0508	dehydrogenase complex catalyzes the overall conversion of
SR35_RS00610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SR35_RS00615	COG3064	Membrane
SR35_RS00620	COG1049	propionate catabolic process, 2-methylcitrate cycle
SR35_RS00645	COG2132	Multicopper oxidase
SR35_RS00650	COG4993	Dehydrogenase
SR35_RS00655	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SR35_RS00660	COG0288	reversible hydration of carbon dioxide
SR35_RS00665	COG1131	(ABC) transporter
SR35_RS00670	COG0842	Transport permease protein
SR35_RS00675	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS00680	COG0726	polysaccharide deacetylase
SR35_RS00690	COG5464	transposase or invertase
SR35_RS00705	COG3539	Fimbrial protein
SR35_RS00710	COG3539	Fimbrial protein
SR35_RS00715	COG3539	Fimbrial protein
SR35_RS00720	COG3539	Fimbrial protein
SR35_RS00725	COG3188	usher protein
SR35_RS00730	COG3121	Chaperone
SR35_RS00735	COG3539	Fimbrial protein
SR35_RS00740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SR35_RS00745	COG0617	tRNA 3'-terminal CCA addition
SR35_RS00755	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SR35_RS00765	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SR35_RS00770	COG1643	Atp-dependent helicase
SR35_RS00780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SR35_RS00785	COG4774	siderophore transport
SR35_RS00790	COG1120	ATPase activity
SR35_RS00795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SR35_RS00800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SR35_RS00820	COG2860	membrane
SR35_RS00825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SR35_RS00840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SR35_RS00845	COG3835	regulator
SR35_RS00855	COG1408	metallophosphoesterase
SR35_RS00870	COG0024	Methionine aminopeptidase
SR35_RS00895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SR35_RS00900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SR35_RS00905	COG0575	Belongs to the CDS family
SR35_RS00910	COG0750	zinc metalloprotease
SR35_RS00920	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
SR35_RS00925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
SR35_RS00950	COG0587	DNA-directed DNA polymerase activity
SR35_RS00960	COG1982	Orn Lys Arg decarboxylase major
SR35_RS00965	COG0346	lactoylglutathione lyase activity
SR35_RS00970	COG0037	tRNA processing
SR35_RS00975	COG4568	rho-dependent transcription termination
SR35_RS00985	COG4681	YaeQ
SR35_RS00990	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SR35_RS00995	COG3015	lipoprotein NlpE involved in copper resistance
SR35_RS01000	COG0791	NLP P60 protein
SR35_RS01010	COG1720	tRNA m6t6A37 methyltransferase activity
SR35_RS01020	COG1464	Belongs to the NlpA lipoprotein family
SR35_RS01025	COG2011	ABC-type metal ion transport system permease component
SR35_RS01030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SR35_RS01035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SR35_RS01070	COG0656	L-ascorbic acid biosynthetic process
SR35_RS01075	COG0583	DNA-binding transcription factor activity
SR35_RS01085	COG2226	methyltransferase
SR35_RS01090	COG0741	lytic transglycosylase activity
SR35_RS01090	COG1388	LysM domain
SR35_RS01100	COG2226	methyltransferase
SR35_RS01110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SR35_RS01130	COG4104	PAAR repeat-containing protein
SR35_RS01135	COG5433	transposase activity
SR35_RS01140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SR35_RS01150	COG1960	acyl-CoA dehydrogenase activity
SR35_RS01160	COG0121	glutamine amidotransferase
SR35_RS01165	COG3034	peptidoglycan biosynthetic process
SR35_RS01170	COG3041	Addiction module toxin RelE StbE family
SR35_RS01175	COG3077	Addiction module antitoxin, RelB DinJ family
SR35_RS01180	COG0791	NLP P60 protein
SR35_RS01185	COG1943	Transposase
SR35_RS01205	COG2161	toxin-antitoxin pair type II binding
SR35_RS01215	COG0454	-acetyltransferase
SR35_RS01220	COG1690	Belongs to the RtcB family
SR35_RS01225	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SR35_RS01230	COG2195	Cleaves the N-terminal amino acid of tripeptides
SR35_RS01240	COG0833	amino acid
SR35_RS01245	COG2040	homocysteine
SR35_RS01250	COG3842	ATPase activity
SR35_RS01255	COG1178	ABC-type Fe3 transport system permease component
SR35_RS01260	COG1662	PFAM IS1 transposase
SR35_RS01265	COG1662	PFAM IS1 transposase
SR35_RS01265	COG3677	Transposase
SR35_RS01270	COG2963	transposase activity
SR35_RS01280	COG3415	Transposase
SR35_RS01280	COG2801	Transposase and inactivated derivatives
SR35_RS01285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SR35_RS01290	COG0129	dihydroxy-acid dehydratase activity
SR35_RS01295	COG2211	Major facilitator Superfamily
SR35_RS01300	COG3507	Belongs to the glycosyl hydrolase 43 family
SR35_RS01305	COG1414	Transcriptional regulator
SR35_RS01310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SR35_RS01315	COG1662	PFAM IS1 transposase
SR35_RS01320	COG1061	Type III restriction enzyme res subunit
SR35_RS01330	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SR35_RS01350	COG0582	viral genome integration into host DNA
SR35_RS01360	COG0583	DNA-binding transcription factor activity
SR35_RS01365	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SR35_RS01370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SR35_RS01375	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SR35_RS01380	COG2080	2 iron, 2 sulfur cluster binding
SR35_RS01385	COG3477	response to acidic pH
SR35_RS01390	COG0727	PFAM Uncharacterised protein family (UPF0153)
SR35_RS01395	COG3121	Chaperone
SR35_RS01405	COG3188	usher protein
SR35_RS01445	COG1388	LysM domain
SR35_RS01455	COG2801	Transposase and inactivated derivatives
SR35_RS01460	COG2207	Transcriptional regulator
SR35_RS01460	COG3708	Transcriptional regulator
SR35_RS01465	COG3059	membrane
SR35_RS01475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SR35_RS01480	COG2207	Transcriptional regulator
SR35_RS01485	COG0247	lactate metabolic process
SR35_RS01490	COG1139	Iron-sulfur cluster binding protein
SR35_RS01495	COG1556	Lactate utilization protein
SR35_RS01525	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SR35_RS01535	COG2200	EAL domain
SR35_RS01535	COG2771	luxR family
SR35_RS01540	COG0583	DNA-binding transcription factor activity
SR35_RS01550	COG0666	response to abiotic stimulus
SR35_RS01560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SR35_RS01565	COG1304	FMN binding
SR35_RS01575	COG0549	Belongs to the carbamate kinase family
SR35_RS01580	COG0402	S-adenosylhomocysteine deaminase activity
SR35_RS01585	COG1064	alcohol dehydrogenase
SR35_RS01600	COG1280	lysine exporter protein (LysE YggA)
SR35_RS01610	COG3829	transcription factor binding
SR35_RS01615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SR35_RS01620	COG0372	Belongs to the citrate synthase family
SR35_RS01625	COG2079	MmgE PrpD family protein
SR35_RS01630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SR35_RS01635	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SR35_RS01640	COG0402	S-adenosylhomocysteine deaminase activity
SR35_RS01645	COG0583	DNA-binding transcription factor activity
SR35_RS01650	COG0288	reversible hydration of carbon dioxide
SR35_RS01660	COG2807	transmembrane transport
SR35_RS01665	COG0110	maltose O-acetyltransferase activity
SR35_RS01670	COG2223	nitrite transmembrane transporter activity
SR35_RS01680	COG2223	nitrite transmembrane transporter activity
SR35_RS01685	COG3250	beta-galactosidase activity
SR35_RS01690	COG1609	Transcriptional regulator
SR35_RS01695	COG1414	Transcriptional regulator
SR35_RS01715	COG3971	2-oxopent-4-enoate hydratase activity
SR35_RS01730	COG2814	Major facilitator Superfamily
SR35_RS01735	COG3122	Protein conserved in bacteria
SR35_RS01745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SR35_RS01780	COG1215	transferase activity, transferring glycosyl groups
SR35_RS01785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SR35_RS01790	COG4521	taurine ABC transporter
SR35_RS01800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SR35_RS01805	COG2175	clavaminate synthase activity
SR35_RS01810	COG0113	porphobilinogen synthase activity
SR35_RS01825	COG2801	Transposase and inactivated derivatives
SR35_RS01835	COG3468	outer membrane autotransporter barrel domain protein
SR35_RS01840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SR35_RS01845	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SR35_RS01855	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
SR35_RS01875	COG1181	Belongs to the D-alanine--D-alanine ligase family
SR35_RS01890	COG1785	Belongs to the alkaline phosphatase family
SR35_RS01900	COG3706	GGDEF domain
SR35_RS01905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SR35_RS01930	COG4126	flavin adenine dinucleotide binding
SR35_RS01950	COG1940	carbohydrate kinase activity
SR35_RS01955	COG2814	Major facilitator Superfamily
SR35_RS01960	COG0419	ATPase involved in DNA repair
SR35_RS01965	COG0420	3'-5' exonuclease activity
SR35_RS01970	COG0745	RESPONSE REGULATOR receiver
SR35_RS01975	COG5002	protein histidine kinase activity
SR35_RS01980	COG1114	Component of the transport system for branched-chain amino acids
SR35_RS01985	COG1113	amino acid transport
SR35_RS01990	COG0366	Alpha amylase catalytic
SR35_RS02010	COG1862	Preprotein translocase
SR35_RS02015	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SR35_RS02020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SR35_RS02025	COG1403	HNH endonuclease
SR35_RS02035	COG3248	Nucleoside-binding outer membrane protein
SR35_RS02040	COG4238	major outer membrane lipoprotein
SR35_RS02050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SR35_RS02050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SR35_RS02065	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
SR35_RS02070	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
SR35_RS02075	COG0667	Aldo Keto reductase
SR35_RS02085	COG0142	geranyltranstransferase activity
SR35_RS02100	COG0693	protein deglycase activity
SR35_RS02105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SR35_RS02115	COG2814	Major facilitator Superfamily
SR35_RS02125	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SR35_RS02130	COG1845	cytochrome c oxidase, subunit III
SR35_RS02135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SR35_RS02140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SR35_RS02145	COG2223	nitrite transmembrane transporter activity
SR35_RS02150	COG3056	Lipoprotein
SR35_RS02155	COG0271	Belongs to the BolA IbaG family
SR35_RS02180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SR35_RS02185	COG0776	regulation of translation
SR35_RS02190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SR35_RS02195	COG1555	photosystem II stabilization
SR35_RS02200	COG0824	Thioesterase
SR35_RS02210	COG4533	DNA binding
SR35_RS02220	COG1522	sequence-specific DNA binding
SR35_RS02225	COG1132	(ABC) transporter
SR35_RS02230	COG1132	(ABC) transporter
SR35_RS02235	COG0347	Belongs to the P(II) protein family
SR35_RS02240	COG0004	ammonium transporteR
SR35_RS02245	COG1946	Acyl-CoA thioesterase
SR35_RS02250	COG3126	Type III secretion system lipoprotein chaperone (YscW)
SR35_RS02255	COG3695	enzyme binding
SR35_RS02260	COG5507	3-demethylubiquinone-9 3-methyltransferase
SR35_RS02265	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SR35_RS02275	COG0110	maltose O-acetyltransferase activity
SR35_RS02290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SR35_RS02295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SR35_RS02300	COG1309	transcriptional regulator
SR35_RS02305	COG3264	Mechanosensitive ion channel
SR35_RS02305	COG1196	nuclear chromosome segregation
SR35_RS02320	COG3923	Primosomal replication protein n
SR35_RS02325	COG2832	Protein of unknown function (DUF454)
SR35_RS02335	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SR35_RS02370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SR35_RS02375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SR35_RS02375	COG4651	solute:proton antiporter activity
SR35_RS02380	COG2223	nitrite transmembrane transporter activity
SR35_RS02385	COG0737	Belongs to the 5'-nucleotidase family
SR35_RS02390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SR35_RS02395	COG3735	TraB family
SR35_RS02400	COG3093	addiction module antidote protein HigA
SR35_RS02405	COG2217	Heavy metal translocating P-type atpase
SR35_RS02410	COG2066	Belongs to the glutaminase family
SR35_RS02415	COG0531	amino acid
SR35_RS02420	COG0789	Transcriptional regulator
SR35_RS02425	COG1585	Membrane protein implicated in regulation of membrane protease activity
SR35_RS02430	COG0330	HflC and HflK could
SR35_RS02435	COG4619	ABC transporter
SR35_RS02440	COG0390	transport system, permease component
SR35_RS02445	COG3118	belongs to the thioredoxin family
SR35_RS02450	COG0300	oxidoreductase activity
SR35_RS02455	COG2755	lipolytic protein G-D-S-L family
SR35_RS02460	COG4181	ATPase activity
SR35_RS02465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
SR35_RS02470	COG3209	COG3209 Rhs family protein
SR35_RS02480	COG3209	COG3209 Rhs family protein
SR35_RS02490	COG2801	Transposase and inactivated derivatives
SR35_RS02500	COG0583	DNA-binding transcription factor activity
SR35_RS02510	COG1414	Transcriptional regulator
SR35_RS02515	COG3960	tartronate-semialdehyde synthase activity
SR35_RS02520	COG3622	Belongs to the hyi family
SR35_RS02525	COG2084	Dehydrogenase
SR35_RS02530	COG1953	Uracil, thiamine, allantoin
SR35_RS02540	COG2233	PERMEase
SR35_RS02545	COG1929	Belongs to the glycerate kinase type-1 family
SR35_RS02550	COG3257	ureidoglycine aminohydrolase activity
SR35_RS02555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SR35_RS02560	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SR35_RS02565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SR35_RS02570	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SR35_RS02580	COG0549	Belongs to the carbamate kinase family
SR35_RS02585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SR35_RS02590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SR35_RS02600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SR35_RS02610	COG1988	membrane-bound metal-dependent
SR35_RS02615	COG2501	S4 domain
SR35_RS02625	COG3539	Fimbrial protein
SR35_RS02630	COG3121	Chaperone
SR35_RS02635	COG3188	usher protein
SR35_RS02640	COG3539	Fimbrial protein
SR35_RS02645	COG3539	Fimbrial protein
SR35_RS02650	COG2197	response regulator
SR35_RS02660	COG0582	viral genome integration into host DNA
SR35_RS02685	COG2801	Transposase and inactivated derivatives
SR35_RS02695	COG2076	Multidrug Resistance protein
SR35_RS02705	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SR35_RS02710	COG1881	PFAM PEBP family protein
SR35_RS02715	COG2207	Transcriptional regulator
SR35_RS02760	COG5562	phage envelope protein
SR35_RS02780	COG4220	transposase activity
SR35_RS02790	COG0500	methyltransferase
SR35_RS02800	COG2207	Transcriptional regulator
SR35_RS02805	COG4571	Outer membrane protease
SR35_RS02815	COG2207	Transcriptional regulator
SR35_RS02825	COG4783	chaperone-mediated protein folding
SR35_RS02830	COG1215	transferase activity, transferring glycosyl groups
SR35_RS02835	COG5002	protein histidine kinase activity
SR35_RS02840	COG0745	RESPONSE REGULATOR receiver
SR35_RS02845	COG1538	Outer membrane efflux protein
SR35_RS02850	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SR35_RS02855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SR35_RS02860	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SR35_RS02865	COG1113	amino acid transport
SR35_RS02870	COG0668	transmembrane transport
SR35_RS02875	COG0778	Nitroreductase
SR35_RS02880	COG2315	Protein conserved in bacteria
SR35_RS02905	COG3385	transposase activity
SR35_RS02910	COG2977	Belongs to the P-Pant transferase superfamily
SR35_RS02915	COG4771	TonB-dependent receptor
SR35_RS02920	COG2382	esterase
SR35_RS02925	COG3251	PFAM MbtH domain protein
SR35_RS02930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SR35_RS02930	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SR35_RS02935	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
SR35_RS02940	COG1120	ATPase activity
SR35_RS02945	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SR35_RS02950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SR35_RS02960	COG4592	Periplasmic binding protein
SR35_RS02965	COG1169	isochorismate synthase
SR35_RS02970	COG1021	2,3-dihydroxybenzoate-AMP ligase
SR35_RS02975	COG1535	isochorismatase
SR35_RS02975	COG3433	isochorismatase activity
SR35_RS02980	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS02985	COG2050	protein possibly involved in aromatic compounds catabolism
SR35_RS02990	COG1966	Carbon starvation protein
SR35_RS02995	COG2879	small protein
SR35_RS03000	COG0371	Dehydrogenase
SR35_RS03005	COG0436	Aminotransferase
SR35_RS03010	COG1475	DNA binding
SR35_RS03015	COG3969	phosphoadenosine phosphosulfate
SR35_RS03020	COG0583	DNA-binding transcription factor activity
SR35_RS03025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SR35_RS03030	COG0450	alkyl hydroperoxide reductase
SR35_RS03035	COG3634	alkyl hydroperoxide reductase activity
SR35_RS03040	COG0589	response to stress
SR35_RS03045	COG1063	alcohol dehydrogenase
SR35_RS03055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SR35_RS03060	COG3719	Belongs to the RNase T2 family
SR35_RS03065	COG0471	metal ion transport
SR35_RS03080	COG3051	citrate lyase alpha subunit
SR35_RS03085	COG2301	Belongs to the HpcH HpaI aldolase family
SR35_RS03095	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SR35_RS03100	COG3290	protein histidine kinase activity
SR35_RS03105	COG4565	transcriptional regulatory protein
SR35_RS03110	COG3069	C4-dicarboxylate transmembrane transporter activity
SR35_RS03135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SR35_RS03145	COG0583	DNA-binding transcription factor activity
SR35_RS03165	COG1686	Belongs to the peptidase S11 family
SR35_RS03170	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SR35_RS03175	COG0772	Belongs to the SEDS family
SR35_RS03180	COG0768	penicillin binding
SR35_RS03190	COG0799	negative regulation of ribosome biogenesis
SR35_RS03195	COG0406	alpha-ribazole phosphatase activity
SR35_RS03205	COG1466	dna polymerase III delta subunit
SR35_RS03220	COG2888	peptidyl-tyrosine sulfation
SR35_RS03225	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
SR35_RS03235	COG2214	Heat shock protein DnaJ domain protein
SR35_RS03240	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
SR35_RS03250	COG2214	Heat shock protein DnaJ domain protein
SR35_RS03255	COG0443	Heat shock 70 kDa protein
SR35_RS03265	COG1126	abc transporter atp-binding protein
SR35_RS03270	COG0765	amino acid transport
SR35_RS03275	COG0765	amino acid transport
SR35_RS03280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR35_RS03290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SR35_RS03295	COG4535	Mg2 and Co2 transporter CorC
SR35_RS03305	COG1702	phosphate starvation-inducible protein PhoH
SR35_RS03315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SR35_RS03355	COG0367	asparagine synthase
SR35_RS03360	COG0647	UMP catabolic process
SR35_RS03365	COG1846	Transcriptional regulator
SR35_RS03365	COG1940	carbohydrate kinase activity
SR35_RS03370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SR35_RS03380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS03380	COG1263	PTS System
SR35_RS03380	COG2190	(PTS) system
SR35_RS03400	COG0735	belongs to the Fur family
SR35_RS03415	COG0716	FMN binding
SR35_RS03425	COG0596	Alpha beta hydrolase
SR35_RS03430	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
SR35_RS03435	COG0033	Phosphoglucomutase
SR35_RS03455	COG0531	amino acid
SR35_RS03460	COG1982	Orn Lys Arg decarboxylase major
SR35_RS03470	COG0745	RESPONSE REGULATOR receiver
SR35_RS03475	COG2205	protein histidine kinase activity
SR35_RS03505	COG3209	COG3209 Rhs family protein
SR35_RS03515	COG3209	COG3209 Rhs family protein
SR35_RS03525	COG5433	transposase activity
SR35_RS03535	COG5433	transposase activity
SR35_RS03540	COG3272	Protein of unknown function (DUF1722)
SR35_RS03545	COG0415	Belongs to the DNA photolyase family
SR35_RS03550	COG3104	oligopeptide transport
SR35_RS03555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SR35_RS03560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SR35_RS03565	COG1984	allophanate hydrolase subunit 2
SR35_RS03580	COG3180	Ammonia monooxygenase
SR35_RS03585	COG3539	Fimbrial protein
SR35_RS03590	COG3121	Chaperone
SR35_RS03595	COG3188	usher protein
SR35_RS03600	COG3539	Fimbrial protein
SR35_RS03605	COG0372	Belongs to the citrate synthase family
SR35_RS03615	COG2009	succinate dehydrogenase
SR35_RS03620	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
SR35_RS03625	COG1053	succinate dehydrogenase
SR35_RS03630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SR35_RS03640	COG0567	Dehydrogenase, E1 component
SR35_RS03645	COG0508	dehydrogenase complex catalyzes the overall conversion of
SR35_RS03655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SR35_RS03660	COG2188	Transcriptional regulator
SR35_RS03665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS03665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS03665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS03670	COG0383	alpha-mannosidase activity
SR35_RS03680	COG1271	oxidase subunit
SR35_RS03685	COG1294	oxidase, subunit
SR35_RS03690	COG4890	Cyd operon protein YbgT
SR35_RS03695	COG3790	cyd operon protein YbgE
SR35_RS03700	COG0824	Thioesterase
SR35_RS03705	COG0811	peptide transport
SR35_RS03710	COG0848	biopolymer transport protein
SR35_RS03715	COG3064	Membrane
SR35_RS03725	COG2885	chlorophyll binding
SR35_RS03730	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
SR35_RS03775	COG3201	nicotinamide mononucleotide transporter
SR35_RS03780	COG1230	cation diffusion facilitator family transporter
SR35_RS03795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SR35_RS03805	COG2017	converts alpha-aldose to the beta-anomer
SR35_RS03815	COG1085	galactose-1-phosphate uridylyltransferase
SR35_RS03820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SR35_RS03825	COG1119	ATPase activity
SR35_RS03830	COG2005	Transcriptional regulator
SR35_RS03830	COG3585	molybdate ion transport
SR35_RS03840	COG0725	ABC transporter, periplasmic molybdate-binding protein
SR35_RS03845	COG4149	molybdate abc transporter
SR35_RS03850	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
SR35_RS03855	COG0561	phosphatase activity
SR35_RS03865	COG0583	DNA-binding transcription factor activity
SR35_RS03870	COG2828	Protein conserved in bacteria
SR35_RS03875	COG0471	metal ion transport
SR35_RS03880	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SR35_RS03885	COG4677	pectinesterase activity
SR35_RS03890	COG1881	PFAM PEBP family protein
SR35_RS03895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SR35_RS03910	COG2226	methyltransferase
SR35_RS03915	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SR35_RS03925	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SR35_RS03940	COG0521	Mo-molybdopterin cofactor biosynthetic process
SR35_RS03950	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
SR35_RS03955	COG0314	molybdopterin synthase activity
SR35_RS03960	COG0670	Belongs to the BI1 family
SR35_RS03970	COG0670	Belongs to the BI1 family
SR35_RS03975	COG0392	lysyltransferase activity
SR35_RS03980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SR35_RS03985	COG3568	Endonuclease Exonuclease Phosphatase
SR35_RS03995	COG0842	Transport permease protein
SR35_RS04000	COG0842	Transport permease protein
SR35_RS04005	COG1131	(ABC) transporter
SR35_RS04015	COG1309	transcriptional regulator
SR35_RS04020	COG0513	Belongs to the DEAD box helicase family
SR35_RS04025	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
SR35_RS04030	COG1199	ATP-dependent helicase activity
SR35_RS04035	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SR35_RS04040	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SR35_RS04050	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
SR35_RS04060	COG4774	siderophore transport
SR35_RS04075	COG0668	transmembrane transport
SR35_RS04080	COG1126	abc transporter atp-binding protein
SR35_RS04085	COG0765	amino acid transport
SR35_RS04090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR35_RS04105	COG5006	permease, DMT superfamily
SR35_RS04110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SR35_RS04115	COG2194	sulfuric ester hydrolase activity
SR35_RS04125	COG1321	iron dependent repressor
SR35_RS04130	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SR35_RS04135	COG1376	ErfK ybiS ycfS ynhG family protein
SR35_RS04140	COG0488	(ABC) transporter
SR35_RS04150	COG0561	phosphatase activity
SR35_RS04155	COG1882	Formate acetyltransferase
SR35_RS04160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SR35_RS04165	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SR35_RS04170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SR35_RS04175	COG0303	'Molybdopterin
SR35_RS04180	COG1446	asparaginase
SR35_RS04185	COG4172	Belongs to the ABC transporter superfamily
SR35_RS04190	COG0747	negative chemotaxis
SR35_RS04200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SR35_RS04205	COG2200	EAL domain
SR35_RS04210	COG2199	diguanylate cyclase activity
SR35_RS04225	COG2133	pyrroloquinoline quinone binding
SR35_RS04230	COG0625	glutathione transferase activity
SR35_RS04235	COG1686	Belongs to the peptidase S11 family
SR35_RS04240	COG1349	DNA-binding transcription factor activity
SR35_RS04245	COG0671	phosphoesterase, PA-phosphatase related
SR35_RS04250	COG2814	Major facilitator Superfamily
SR35_RS04260	COG0561	phosphatase activity
SR35_RS04265	COG0738	Major facilitator superfamily
SR35_RS04270	COG3226	Transcriptional regulator
SR35_RS04285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SR35_RS04295	COG0778	Nitroreductase
SR35_RS04315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SR35_RS04320	COG3842	ATPase activity
SR35_RS04325	COG1176	ABC-type spermidine putrescine transport system, permease component I
SR35_RS04330	COG1177	transmembrane transport
SR35_RS04345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR35_RS04350	COG4160	amino acid transport
SR35_RS04355	COG4215	(ABC) transporter
SR35_RS04360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR35_RS04365	COG1126	abc transporter atp-binding protein
SR35_RS04380	COG3023	N-Acetylmuramoyl-L-alanine amidase
SR35_RS04385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SR35_RS04390	COG0702	epimerase
SR35_RS04395	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
SR35_RS04400	COG0028	Belongs to the TPP enzyme family
SR35_RS04405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SR35_RS04415	COG2431	L-lysine efflux transmembrane transporter activity
SR35_RS04430	COG3593	DNA synthesis involved in DNA repair
SR35_RS04435	COG2990	Protein conserved in bacteria
SR35_RS04440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SR35_RS04445	COG0577	efflux transmembrane transporter activity
SR35_RS04445	COG1136	(ABC) transporter
SR35_RS04450	COG1278	Cold shock
SR35_RS04460	COG0542	response to heat
SR35_RS04480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SR35_RS04485	COG4988	ABC transporter
SR35_RS04490	COG0492	ferredoxin-NADP+ reductase activity
SR35_RS04495	COG1522	sequence-specific DNA binding
SR35_RS04500	COG1178	ABC-type Fe3 transport system permease component
SR35_RS04500	COG1674	ftsk spoiiie
SR35_RS04510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SR35_RS04520	COG0243	molybdopterin cofactor binding
SR35_RS04525	COG0437	4 iron, 4 sulfur cluster binding
SR35_RS04530	COG3302	dmso reductase anchor subunit
SR35_RS04535	COG1335	isochorismatase
SR35_RS04545	COG0531	amino acid
SR35_RS04550	COG0583	DNA-binding transcription factor activity
SR35_RS04555	COG2249	NAD(P)H dehydrogenase (quinone) activity
SR35_RS04560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SR35_RS04565	COG1882	Formate acetyltransferase
SR35_RS04570	COG2116	formate transmembrane transporter activity
SR35_RS04575	COG1944	ATP diphosphatase activity
SR35_RS04580	COG2323	membrane
SR35_RS04595	COG0501	Belongs to the peptidase M48B family
SR35_RS04605	COG0539	negative regulation of cytoplasmic translation
SR35_RS04615	COG2333	competence protein COMEC
SR35_RS04615	COG0658	competence protein
SR35_RS04620	COG1132	(ABC) transporter
SR35_RS04625	COG1663	tetraacyldisaccharide 4'-kinase activity
SR35_RS04630	COG3214	Protein conserved in bacteria
SR35_RS04645	COG3173	Aminoglycoside phosphotransferase
SR35_RS04650	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SR35_RS04655	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SR35_RS04665	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
SR35_RS04675	COG2989	Protein conserved in bacteria
SR35_RS04680	COG3108	Peptidase M15
SR35_RS04685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SR35_RS04690	COG1448	Aminotransferase
SR35_RS04715	COG0308	aminopeptidase N
SR35_RS04720	COG1116	anion transmembrane transporter activity
SR35_RS04725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SR35_RS04735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SR35_RS04740	COG0431	NADPH-dependent FMN reductase
SR35_RS04745	COG3539	Fimbrial protein
SR35_RS04750	COG3121	Chaperone
SR35_RS04755	COG3188	usher protein
SR35_RS04760	COG3539	Fimbrial protein
SR35_RS04765	COG3539	Fimbrial protein
SR35_RS04770	COG3539	Fimbrial protein
SR35_RS04775	COG3121	Chaperone
SR35_RS04790	COG3217	Mosc domain protein beta barrel domain protein
SR35_RS04790	COG0633	Ferredoxin
SR35_RS04800	COG0488	(ABC) transporter
SR35_RS04805	COG2995	paraquat-inducible protein a
SR35_RS04810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SR35_RS04810	COG3008	intermembrane lipid transfer
SR35_RS04815	COG3009	Protein conserved in bacteria
SR35_RS04820	COG3130	regulation of translation
SR35_RS04830	COG1067	ATP-dependent peptidase activity
SR35_RS04840	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
SR35_RS04840	COG2885	chlorophyll binding
SR35_RS04855	COG3070	regulator of competence-specific genes
SR35_RS04860	COG1289	transmembrane transporter activity
SR35_RS04865	COG3304	Inner membrane component domain
SR35_RS04870	COG0210	DNA helicase
SR35_RS04890	COG1832	CoA-binding protein
SR35_RS04905	COG1254	Belongs to the acylphosphatase family
SR35_RS04910	COG2920	part of a sulfur-relay system
SR35_RS04915	COG0670	Belongs to the BI1 family
SR35_RS04925	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SR35_RS04930	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SR35_RS04935	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
SR35_RS04940	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SR35_RS04945	COG1999	signal sequence binding
SR35_RS04950	COG1773	rubredoxin
SR35_RS04955	COG1271	oxidase subunit
SR35_RS04960	COG1294	oxidase, subunit
SR35_RS04975	COG3206	protein involved in exopolysaccharide biosynthesis
SR35_RS04975	COG0489	protein tyrosine kinase activity
SR35_RS04980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SR35_RS04985	COG1596	polysaccharide export
SR35_RS04990	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SR35_RS05015	COG1662	PFAM IS1 transposase
SR35_RS05020	COG1278	Cold shock
SR35_RS05025	COG1278	Cold shock
SR35_RS05040	COG0348	domain, Protein
SR35_RS05050	COG1879	ABC-type sugar transport system periplasmic component
SR35_RS05055	COG0745	RESPONSE REGULATOR receiver
SR35_RS05060	COG3005	denitrification pathway
SR35_RS05065	COG0243	molybdopterin cofactor binding
SR35_RS05070	COG3381	protein complex oligomerization
SR35_RS05110	COG3729	General stress protein
SR35_RS05115	COG2233	PERMEase
SR35_RS05150	COG1309	transcriptional regulator
SR35_RS05155	COG0506	proline dehydrogenase activity
SR35_RS05155	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SR35_RS05155	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SR35_RS05165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SR35_RS05180	COG2822	iron ion transport
SR35_RS05185	COG2837	iron assimilation
SR35_RS05195	COG1702	phosphate starvation-inducible protein PhoH
SR35_RS05200	COG3658	cytochrome
SR35_RS05205	COG1215	transferase activity, transferring glycosyl groups
SR35_RS05210	COG1649	PFAM Uncharacterised BCR, COG1649
SR35_RS05210	COG0726	polysaccharide deacetylase
SR35_RS05215	COG0457	Tetratricopeptide repeat
SR35_RS05220	COG3706	GGDEF domain
SR35_RS05225	COG2801	Transposase and inactivated derivatives
SR35_RS05265	COG3381	protein complex oligomerization
SR35_RS05275	COG1462	curli production assembly transport component CsgG
SR35_RS05290	COG2197	response regulator
SR35_RS05320	COG1662	PFAM IS1 transposase
SR35_RS05325	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SR35_RS05330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SR35_RS05355	COG2943	transferase activity, transferring hexosyl groups
SR35_RS05360	COG5645	(Lipo)protein
SR35_RS05380	COG1560	Kdo2-lipid A biosynthetic process
SR35_RS05390	COG2353	YceI-like domain
SR35_RS05395	COG3038	cytochrome b561
SR35_RS05430	COG2999	glutathione oxidoreductase activity
SR35_RS05440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SR35_RS05450	COG0673	inositol 2-dehydrogenase activity
SR35_RS05455	COG0728	peptidoglycan biosynthetic process
SR35_RS05460	COG3418	PFAM FlgN family protein
SR35_RS05465	COG2747	anti-sigma28 factor FlgM
SR35_RS05470	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
SR35_RS05475	COG1815	bacterial-type flagellum-dependent cell motility
SR35_RS05480	COG1558	bacterial-type flagellum-dependent cell motility
SR35_RS05485	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
SR35_RS05490	COG1749	Flagellar hook protein flgE
SR35_RS05495	COG4787	bacterial-type flagellum-dependent cell motility
SR35_RS05500	COG4786	Flagellar basal body rod
SR35_RS05515	COG3951	Flagellar rod assembly protein muramidase FlgJ
SR35_RS05515	COG1705	Flagellar rod assembly protein muramidase FlgJ
SR35_RS05520	COG1256	bacterial-type flagellum assembly
SR35_RS05525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SR35_RS05530	COG1530	ribonuclease E activity
SR35_RS05540	COG0564	pseudouridine synthase activity
SR35_RS05545	COG0424	maF-like protein
SR35_RS05550	COG1399	metal-binding, possibly nucleic acid-binding protein
SR35_RS05570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SR35_RS05575	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS05585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SR35_RS05590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SR35_RS05595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SR35_RS05605	COG0470	DNA polymerase III
SR35_RS05610	COG0084	hydrolase, TatD family'
SR35_RS05615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS05615	COG1263	PTS System
SR35_RS05620	COG4773	Receptor
SR35_RS05625	COG0537	adenosine 5'-monophosphoramidase activity
SR35_RS05630	COG5633	Lipoprotein
SR35_RS05635	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
SR35_RS05655	COG1252	NADH dehydrogenase
SR35_RS05660	COG3134	Outer membrane lipoprotein
SR35_RS05665	COG1309	transcriptional regulator
SR35_RS05675	COG1388	LysM domain
SR35_RS05675	COG1376	ErfK ybiS ycfS ynhG family protein
SR35_RS05680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SR35_RS05685	COG4763	Acyl-transferase
SR35_RS05690	COG4591	ABC-type transport system involved in lipoprotein release permease component
SR35_RS05695	COG1136	(ABC) transporter
SR35_RS05700	COG4591	ABC-type transport system involved in lipoprotein release permease component
SR35_RS05710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SR35_RS05715	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SR35_RS05725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SR35_RS05730	COG1177	transmembrane transport
SR35_RS05740	COG3842	ATPase activity
SR35_RS05755	COG2850	peptidyl-arginine hydroxylation
SR35_RS05760	COG2205	protein histidine kinase activity
SR35_RS05765	COG0745	RESPONSE REGULATOR receiver
SR35_RS05770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SR35_RS05790	COG1187	pseudouridine synthase activity
SR35_RS05795	COG0538	isocitrate dehydrogenase activity
SR35_RS05800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SR35_RS05815	COG0582	viral genome integration into host DNA
SR35_RS05830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SR35_RS05835	COG4197	protein conserved in bacteria, prophage-related
SR35_RS05850	COG4626	Terminase
SR35_RS05850	COG1802	Transcriptional regulator
SR35_RS05860	COG4695	Portal protein
SR35_RS05865	COG3299	homolog of phage Mu protein gp47
SR35_RS05870	COG3778	Protein conserved in bacteria
SR35_RS05885	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SR35_RS05895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SR35_RS05900	COG1403	HNH endonuclease
SR35_RS05915	COG5562	phage envelope protein
SR35_RS05920	COG0789	Transcriptional regulator
SR35_RS05925	COG2200	EAL domain
SR35_RS05950	COG2200	EAL domain
SR35_RS05995	COG2894	cell division
SR35_RS06025	COG0179	Fumarylacetoacetate (FAA) hydrolase
SR35_RS06040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SR35_RS06045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SR35_RS06050	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SR35_RS06065	COG2719	SpoVR family
SR35_RS06075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SR35_RS06085	COG1619	proteins homologs of microcin C7 resistance protein MccF
SR35_RS06095	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
SR35_RS06100	COG2261	transglycosylase associated protein
SR35_RS06115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS06115	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SR35_RS06115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SR35_RS06120	COG1461	Dihydroxyacetone kinase
SR35_RS06125	COG2376	Dihydroxyacetone kinase
SR35_RS06130	COG3284	Transcriptional regulator
SR35_RS06135	COG3468	outer membrane autotransporter barrel domain protein
SR35_RS06145	COG0012	GTP binding
SR35_RS06160	COG0659	secondary active sulfate transmembrane transporter activity
SR35_RS06165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SR35_RS06190	COG2890	protein-(glutamine-N5) methyltransferase activity
SR35_RS06195	COG3094	Invasion gene expression up-regulator, SirB
SR35_RS06200	COG2912	Transglutaminase-like superfamily
SR35_RS06225	COG0387	Pfam Sodium calcium exchanger
SR35_RS06230	COG4572	Cation transport regulator
SR35_RS06235	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
SR35_RS06240	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
SR35_RS06245	COG4932	domain protein
SR35_RS06250	COG2197	response regulator
SR35_RS06255	COG3850	Histidine kinase
SR35_RS06265	COG2223	nitrite transmembrane transporter activity
SR35_RS06270	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SR35_RS06275	COG1140	nitrate reductase beta subunit
SR35_RS06280	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SR35_RS06285	COG2181	nitrate reductase activity
SR35_RS06305	COG0788	formyltetrahydrofolate deformylase activity
SR35_RS06315	COG1752	Esterase of the alpha-beta hydrolase superfamily
SR35_RS06320	COG0745	RESPONSE REGULATOR receiver
SR35_RS06325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SR35_RS06335	COG1435	thymidine kinase activity
SR35_RS06350	COG1454	alcohol dehydrogenase
SR35_RS06350	COG1012	belongs to the aldehyde dehydrogenase family
SR35_RS06355	COG2095	MarC family integral membrane protein
SR35_RS06360	COG4166	transmembrane transport
SR35_RS06365	COG0601	transmembrane transport
SR35_RS06370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SR35_RS06375	COG0444	Belongs to the ABC transporter superfamily
SR35_RS06380	COG4608	Belongs to the ABC transporter superfamily
SR35_RS06400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SR35_RS06405	COG2350	Protein conserved in bacteria
SR35_RS06410	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
SR35_RS06415	COG1607	acyl-coa hydrolase
SR35_RS06430	COG3047	cAMP biosynthetic process
SR35_RS06435	COG3685	Protein conserved in bacteria
SR35_RS06440	COG3685	Protein conserved in bacteria
SR35_RS06445	COG3729	General stress protein
SR35_RS06460	COG0135	phosphoribosylanthranilate isomerase activity
SR35_RS06460	COG0134	indole-3-glycerol-phosphate synthase activity
SR35_RS06465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SR35_RS06465	COG0512	Glutamine amidotransferase of anthranilate synthase
SR35_RS06470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SR35_RS06475	COG0613	PHP domain protein
SR35_RS06480	COG0009	L-threonylcarbamoyladenylate synthase
SR35_RS06490	COG1187	pseudouridine synthase activity
SR35_RS06495	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
SR35_RS06500	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS06510	COG0616	signal peptide processing
SR35_RS06525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SR35_RS06530	COG0583	DNA-binding transcription factor activity
SR35_RS06550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SR35_RS06560	COG0671	phosphoesterase, PA-phosphatase related
SR35_RS06565	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
SR35_RS06570	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
SR35_RS06580	COG0023	Translation Initiation Factor
SR35_RS06590	COG1349	DNA-binding transcription factor activity
SR35_RS06600	COG5001	Diguanylate cyclase
SR35_RS06615	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SR35_RS06615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SR35_RS06620	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SR35_RS06625	COG2852	Protein conserved in bacteria
SR35_RS06630	COG4172	Belongs to the ABC transporter superfamily
SR35_RS06635	COG4172	Belongs to the ABC transporter superfamily
SR35_RS06640	COG4171	peptide transport system, permease
SR35_RS06645	COG4168	peptide transport system, permease
SR35_RS06650	COG4166	transmembrane transport
SR35_RS06665	COG0531	amino acid
SR35_RS06670	COG0174	glutamine synthetase
SR35_RS06675	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SR35_RS06680	COG1917	Cupin 2, conserved barrel domain protein
SR35_RS06680	COG1396	sequence-specific DNA binding
SR35_RS06685	COG1012	belongs to the aldehyde dehydrogenase family
SR35_RS06690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SR35_RS06695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SR35_RS06700	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
SR35_RS06705	COG1842	Phage shock protein A
SR35_RS06715	COG1983	PspC domain protein
SR35_RS06725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SR35_RS06730	COG0366	Alpha amylase catalytic
SR35_RS06735	COG1653	transport
SR35_RS06740	COG1175	transmembrane transport
SR35_RS06745	COG0395	ABC-type sugar transport system, permease component
SR35_RS06750	COG1063	alcohol dehydrogenase
SR35_RS06755	COG1082	Xylose isomerase domain protein TIM barrel
SR35_RS06760	COG0673	inositol 2-dehydrogenase activity
SR35_RS06765	COG1554	hydrolase, family 65, central catalytic
SR35_RS06770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SR35_RS06785	COG1609	Transcriptional regulator
SR35_RS06790	COG3106	COG3106 Predicted ATPase
SR35_RS06800	COG3283	Transcriptional regulator of aromatic amino acids metabolism
SR35_RS06805	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SR35_RS06810	COG4948	Mandelate Racemase Muconate Lactonizing
SR35_RS06815	COG2866	Carboxypeptidase
SR35_RS06820	COG0702	epimerase
SR35_RS06825	COG1073	alpha beta
SR35_RS06830	COG0583	DNA-binding transcription factor activity
SR35_RS06840	COG4166	transmembrane transport
SR35_RS06845	COG0668	transmembrane transport
SR35_RS06855	COG3182	Iron-regulated membrane protein
SR35_RS06860	COG0589	response to stress
SR35_RS06865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SR35_RS06870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SR35_RS06875	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SR35_RS06885	COG1473	amidohydrolase
SR35_RS06890	COG1473	amidohydrolase
SR35_RS06895	COG0583	DNA-binding transcription factor activity
SR35_RS06905	COG2840	Smr protein MutS2
SR35_RS06910	COG3706	GGDEF domain
SR35_RS06925	COG0513	Belongs to the DEAD box helicase family
SR35_RS06935	COG0589	response to stress
SR35_RS06940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SR35_RS06945	COG0674	pyruvate-flavodoxin oxidoreductase activity
SR35_RS06945	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SR35_RS06945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SR35_RS06945	COG1013	pyruvate-flavodoxin oxidoreductase activity
SR35_RS06950	COG3042	response to heat
SR35_RS06955	COG3187	Heat shock protein
SR35_RS06960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SR35_RS06965	COG2911	Protein conserved in bacteria
SR35_RS06975	COG3784	Protein of unknown function (DUF1318)
SR35_RS06980	COG2207	Transcriptional regulator
SR35_RS06985	COG1012	belongs to the aldehyde dehydrogenase family
SR35_RS06990	COG3733	amine oxidase
SR35_RS06995	COG2030	dehydratase
SR35_RS06995	COG1012	belongs to the aldehyde dehydrogenase family
SR35_RS07000	COG3396	Phenylacetate-CoA oxygenase
SR35_RS07005	COG3460	Phenylacetate-CoA oxygenase
SR35_RS07010	COG3396	Phenylacetate-CoA oxygenase
SR35_RS07015	COG2151	metal-sulfur cluster biosynthetic enzyme
SR35_RS07020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SR35_RS07025	COG1024	Enoyl-CoA hydratase
SR35_RS07030	COG1024	Enoyl-CoA hydratase
SR35_RS07035	COG1250	3-hydroxyacyl-CoA dehydrogenase
SR35_RS07040	COG2050	protein possibly involved in aromatic compounds catabolism
SR35_RS07045	COG0183	Belongs to the thiolase family
SR35_RS07050	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SR35_RS07055	COG3327	negative regulation of DNA-templated transcription, initiation
SR35_RS07060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SR35_RS07080	COG2826	transposase and inactivated derivatives, IS30 family
SR35_RS07090	COG0667	Aldo Keto reductase
SR35_RS07100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SR35_RS07105	COG4589	Belongs to the CDS family
SR35_RS07110	COG2267	carboxylic ester hydrolase activity
SR35_RS07115	COG2453	phosphatase
SR35_RS07115	COG0671	phosphoesterase, PA-phosphatase related
SR35_RS07125	COG1643	Atp-dependent helicase
SR35_RS07130	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SR35_RS07135	COG1012	belongs to the aldehyde dehydrogenase family
SR35_RS07140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SR35_RS07145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SR35_RS07150	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SR35_RS07155	COG3038	cytochrome b561
SR35_RS07170	COG0840	transmembrane signaling receptor activity
SR35_RS07175	COG0583	DNA-binding transcription factor activity
SR35_RS07180	COG5383	Protein conserved in bacteria
SR35_RS07195	COG2841	Protein conserved in bacteria
SR35_RS07200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SR35_RS07205	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SR35_RS07210	COG1275	C4-dicarboxylate transporter malic acid transport protein
SR35_RS07215	COG0500	methyltransferase
SR35_RS07235	COG0675	Transposase, IS605 OrfB family
SR35_RS07240	COG3135	benzoate transporter
SR35_RS07245	COG1396	sequence-specific DNA binding
SR35_RS07250	COG0826	peptidase U32
SR35_RS07260	COG1724	mRNA binding
SR35_RS07265	COG1598	PFAM Uncharacterised protein family UPF0150
SR35_RS07270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SR35_RS07275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SR35_RS07280	COG3842	ATPase activity
SR35_RS07285	COG1176	ABC-type spermidine putrescine transport system, permease component I
SR35_RS07290	COG1177	transmembrane transport
SR35_RS07315	COG3238	Protein conserved in bacteria
SR35_RS07320	COG1247	-acetyltransferase
SR35_RS07325	COG2130	NADP-dependent
SR35_RS07330	COG1802	Transcriptional regulator
SR35_RS07335	COG4772	TonB-dependent receptor
SR35_RS07340	COG3391	amine dehydrogenase activity
SR35_RS07345	COG1113	amino acid transport
SR35_RS07350	COG0625	glutathione transferase activity
SR35_RS07360	COG3209	COG3209 Rhs family protein
SR35_RS07370	COG5433	transposase activity
SR35_RS07375	COG5433	transposase activity
SR35_RS07385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SR35_RS07390	COG2162	N-hydroxyarylamine O-acetyltransferase activity
SR35_RS07395	COG0384	phenazine biosynthesis protein PhzF
SR35_RS07400	COG2181	nitrate reductase activity
SR35_RS07405	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
SR35_RS07410	COG1140	nitrate reductase beta subunit
SR35_RS07415	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SR35_RS07420	COG2223	nitrite transmembrane transporter activity
SR35_RS07430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SR35_RS07435	COG0697	spore germination
SR35_RS07440	COG3383	formate dehydrogenase (NAD+) activity
SR35_RS07440	COG0243	molybdopterin cofactor binding
SR35_RS07445	COG3383	formate dehydrogenase (NAD+) activity
SR35_RS07445	COG0243	molybdopterin cofactor binding
SR35_RS07450	COG0437	4 iron, 4 sulfur cluster binding
SR35_RS07455	COG2864	formate dehydrogenase
SR35_RS07460	COG3093	addiction module antidote protein HigA
SR35_RS07465	COG1064	alcohol dehydrogenase
SR35_RS07485	COG1764	response to oxidative stress
SR35_RS07490	COG4608	Belongs to the ABC transporter superfamily
SR35_RS07495	COG0444	Belongs to the ABC transporter superfamily
SR35_RS07500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SR35_RS07505	COG0601	transmembrane transport
SR35_RS07510	COG0747	negative chemotaxis
SR35_RS07515	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SR35_RS07520	COG2200	EAL domain
SR35_RS07520	COG2199	diguanylate cyclase activity
SR35_RS07520	COG2202	Pas domain
SR35_RS07525	COG3706	GGDEF domain
SR35_RS07530	COG1649	PFAM Uncharacterised BCR, COG1649
SR35_RS07535	COG0531	amino acid
SR35_RS07540	COG0076	glutamate decarboxylase activity
SR35_RS07550	COG0612	Peptidase, M16
SR35_RS07555	COG4771	TonB-dependent receptor
SR35_RS07560	COG4178	(ABC) transporter
SR35_RS07565	COG0641	radical SAM
SR35_RS07570	COG3119	arylsulfatase activity
SR35_RS07575	COG2207	Transcriptional regulator
SR35_RS07585	COG0243	molybdopterin cofactor binding
SR35_RS07595	COG3539	Fimbrial protein
SR35_RS07600	COG3539	Fimbrial protein
SR35_RS07605	COG3539	Fimbrial protein
SR35_RS07610	COG3188	usher protein
SR35_RS07615	COG4977	sequence-specific DNA binding
SR35_RS07620	COG3550	peptidyl-serine autophosphorylation
SR35_RS07625	COG1396	sequence-specific DNA binding
SR35_RS07635	COG3210	domain, Protein
SR35_RS07635	COG2911	Protein conserved in bacteria
SR35_RS07685	COG3781	membrane
SR35_RS07700	COG2199	diguanylate cyclase activity
SR35_RS07710	COG2066	Belongs to the glutaminase family
SR35_RS07715	COG1012	belongs to the aldehyde dehydrogenase family
SR35_RS07720	COG0583	DNA-binding transcription factor activity
SR35_RS07740	COG1846	Transcriptional regulator
SR35_RS07745	COG4977	sequence-specific DNA binding
SR35_RS07755	COG0697	spore germination
SR35_RS07760	COG2814	Major facilitator Superfamily
SR35_RS07770	COG3706	GGDEF domain
SR35_RS07775	COG3111	PFAM Bacterial OB fold (BOF) protein
SR35_RS07780	COG1546	Belongs to the CinA family
SR35_RS07785	COG0339	signal peptide processing
SR35_RS07790	COG4221	oxidoreductase activity
SR35_RS07795	COG1802	Transcriptional regulator
SR35_RS07805	COG0246	Mannitol dehydrogenase
SR35_RS07810	COG0477	Major facilitator Superfamily
SR35_RS07820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SR35_RS07825	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SR35_RS07830	COG5301	cellulose 1,4-beta-cellobiosidase activity
SR35_RS07835	COG4220	transposase activity
SR35_RS07845	COG5562	phage envelope protein
SR35_RS07860	COG1278	Cold shock
SR35_RS07870	COG3772	lysozyme
SR35_RS07885	COG1278	Cold shock
SR35_RS07890	COG1278	Cold shock
SR35_RS07895	COG0484	heat shock protein binding
SR35_RS07900	COG1403	HNH endonuclease
SR35_RS07920	COG2026	Addiction module toxin, RelE StbE family
SR35_RS07925	COG3077	Addiction module antitoxin, RelB DinJ family
SR35_RS07945	COG1396	sequence-specific DNA binding
SR35_RS07985	COG0582	viral genome integration into host DNA
SR35_RS07990	COG1063	alcohol dehydrogenase
SR35_RS07995	COG4948	Mandelate Racemase Muconate Lactonizing
SR35_RS08020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SR35_RS08035	COG0243	molybdopterin cofactor binding
SR35_RS08040	COG0243	molybdopterin cofactor binding
SR35_RS08045	COG0437	4 iron, 4 sulfur cluster binding
SR35_RS08050	COG3302	dmso reductase anchor subunit
SR35_RS08055	COG3381	protein complex oligomerization
SR35_RS08065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SR35_RS08075	COG0583	DNA-binding transcription factor activity
SR35_RS08080	COG2814	Major facilitator Superfamily
SR35_RS08095	COG3591	Belongs to the peptidase S1B family
SR35_RS08110	COG0628	permease
SR35_RS08115	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
SR35_RS08120	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
SR35_RS08130	COG0531	amino acid
SR35_RS08140	COG3136	membrane protein required for alginate biosynthesis
SR35_RS08145	COG0745	RESPONSE REGULATOR receiver
SR35_RS08150	COG2205	protein histidine kinase activity
SR35_RS08160	COG0114	fumarate hydratase activity
SR35_RS08165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SR35_RS08165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SR35_RS08170	COG1482	cell wall glycoprotein biosynthetic process
SR35_RS08175	COG5339	Protein conserved in bacteria
SR35_RS08185	COG2211	Major facilitator Superfamily
SR35_RS08190	COG3250	beta-galactosidase activity
SR35_RS08195	COG1309	transcriptional regulator
SR35_RS08200	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS08205	COG1609	Transcriptional regulator
SR35_RS08210	COG1263	PTS System
SR35_RS08210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS08215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SR35_RS08225	COG0673	inositol 2-dehydrogenase activity
SR35_RS08265	COG4659	FMN binding
SR35_RS08275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SR35_RS08285	COG3104	oligopeptide transport
SR35_RS08290	COG0625	glutathione transferase activity
SR35_RS08295	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
SR35_RS08310	COG3895	Periplasmic Protein
SR35_RS08320	COG3133	Outer membrane lipoprotein
SR35_RS08335	COG1566	PFAM secretion protein HlyD family protein
SR35_RS08340	COG1289	transmembrane transporter activity
SR35_RS08345	COG2032	superoxide dismutase activity
SR35_RS08350	COG4989	oxidoreductase activity
SR35_RS08355	COG3313	Fe-S protein
SR35_RS08360	COG1309	transcriptional regulator
SR35_RS08365	COG1902	pentaerythritol trinitrate reductase activity
SR35_RS08370	COG0346	lactoylglutathione lyase activity
SR35_RS08375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SR35_RS08380	COG1201	RNA secondary structure unwinding
SR35_RS08385	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
SR35_RS08390	COG0791	NLP P60 protein
SR35_RS08395	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SR35_RS08400	COG2814	Major facilitator Superfamily
SR35_RS08415	COG0583	DNA-binding transcription factor activity
SR35_RS08420	COG2814	Major facilitator Superfamily
SR35_RS08425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SR35_RS08430	COG0307	riboflavin synthase, alpha
SR35_RS08440	COG3468	outer membrane autotransporter barrel domain protein
SR35_RS08460	COG4529	Protein conserved in bacteria
SR35_RS08470	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
SR35_RS08475	COG0437	4 iron, 4 sulfur cluster binding
SR35_RS08485	COG2414	aldehyde ferredoxin oxidoreductase
SR35_RS08490	COG0437	4 iron, 4 sulfur cluster binding
SR35_RS08500	COG0469	pyruvate kinase activity
SR35_RS08505	COG4238	major outer membrane lipoprotein
SR35_RS08510	COG1376	ErfK ybiS ycfS ynhG family protein
SR35_RS08525	COG0719	Fe-S assembly protein
SR35_RS08530	COG0396	ATPase activity
SR35_RS08535	COG0719	Fe-S assembly protein
SR35_RS08540	COG0316	Belongs to the HesB IscA family
SR35_RS08550	COG2050	protein possibly involved in aromatic compounds catabolism
SR35_RS08555	COG0277	FAD linked oxidase domain protein
SR35_RS08555	COG0247	lactate metabolic process
SR35_RS08560	COG0628	permease
SR35_RS08570	COG0738	Major facilitator superfamily
SR35_RS08575	COG2271	Major facilitator Superfamily
SR35_RS08590	COG4670	ketone body catabolic process
SR35_RS08595	COG1960	acyl-CoA dehydrogenase activity
SR35_RS08600	COG2207	Transcriptional regulator
SR35_RS08600	COG1917	Cupin 2, conserved barrel domain protein
SR35_RS08610	COG2086	electron transfer activity
SR35_RS08615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SR35_RS08620	COG0644	oxidoreductase
SR35_RS08625	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
SR35_RS08630	COG0318	PFAM AMP-dependent synthetase and ligase
SR35_RS08635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SR35_RS08635	COG0574	Belongs to the PEP-utilizing enzyme family
SR35_RS08650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SR35_RS08655	COG4256	Hemin uptake protein
SR35_RS08665	COG2200	EAL domain
SR35_RS08670	COG0791	NLP P60 protein
SR35_RS08680	COG0386	Belongs to the glutathione peroxidase family
SR35_RS08695	COG0072	phenylalanine-tRNA ligase activity
SR35_RS08695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SR35_RS08740	COG3137	Salt-induced outer membrane protein
SR35_RS08745	COG1105	Belongs to the carbohydrate kinase PfkB family
SR35_RS08755	COG3001	Fructosamine kinase
SR35_RS08765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SR35_RS08770	COG1988	membrane-bound metal-dependent
SR35_RS08775	COG1823	symporter activity
SR35_RS08790	COG0753	catalase activity
SR35_RS08800	COG1486	melibiose metabolic process
SR35_RS08805	COG2169	Transcriptional regulator
SR35_RS08805	COG1917	Cupin 2, conserved barrel domain protein
SR35_RS08810	COG1447	Phosphotransferase system cellobiose-specific component IIA
SR35_RS08815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SR35_RS08820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SR35_RS08825	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SR35_RS08840	COG0322	excinuclease ABC activity
SR35_RS08850	COG3678	ATP-independent chaperone mediated protein folding
SR35_RS08880	COG0708	Exodeoxyribonuclease III
SR35_RS08885	COG0398	Pfam SNARE associated Golgi protein
SR35_RS08895	COG0398	Pfam SNARE associated Golgi protein
SR35_RS08900	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SR35_RS08905	COG4134	Bacterial extracellular solute-binding protein
SR35_RS08910	COG4135	transport system, permease component
SR35_RS08915	COG4136	ATPase activity
SR35_RS08920	COG2897	thiosulfate sulfurtransferase activity
SR35_RS08925	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SR35_RS08930	COG0494	nUDIX hydrolase
SR35_RS08940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SR35_RS08950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SR35_RS08965	COG0778	Nitroreductase
SR35_RS08975	COG0616	signal peptide processing
SR35_RS08980	COG0252	asparaginase activity
SR35_RS08985	COG1335	isochorismatase
SR35_RS08990	COG2814	Major facilitator Superfamily
SR35_RS08995	COG1349	DNA-binding transcription factor activity
SR35_RS09000	COG0667	Aldo Keto reductase
SR35_RS09005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SR35_RS09010	COG0191	fructose-bisphosphate aldolase activity
SR35_RS09015	COG1063	alcohol dehydrogenase
SR35_RS09020	COG2271	Major facilitator Superfamily
SR35_RS09025	COG1063	alcohol dehydrogenase
SR35_RS09030	COG3139	Protein of unknown function (DUF1315)
SR35_RS09040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SR35_RS09045	COG0676	glucose-6-phosphate 1-epimerase activity
SR35_RS09050	COG0656	L-ascorbic acid biosynthetic process
SR35_RS09055	COG3713	MltA-interacting MipA family protein
SR35_RS09060	COG2766	serine protein kinase
SR35_RS09070	COG2199	diguanylate cyclase activity
SR35_RS09075	COG2199	diguanylate cyclase activity
SR35_RS09080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SR35_RS09095	COG2207	Transcriptional regulator
SR35_RS09100	COG2807	transmembrane transport
SR35_RS09105	COG3189	MarR family transcriptional regulator
SR35_RS09110	COG3042	response to heat
SR35_RS09115	COG2199	diguanylate cyclase activity
SR35_RS09115	COG2203	Gaf domain
SR35_RS09125	COG2261	transglycosylase associated protein
SR35_RS09135	COG3615	Tellurite resistance protein tehB
SR35_RS09145	COG0583	DNA-binding transcription factor activity
SR35_RS09150	COG0473	3-isopropylmalate dehydrogenase activity
SR35_RS09155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SR35_RS09160	COG4638	Rieske (2fe-2S)
SR35_RS09165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SR35_RS09170	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SR35_RS09175	COG0318	PFAM AMP-dependent synthetase and ligase
SR35_RS09180	COG3065	identical protein binding
SR35_RS09185	COG1214	PFAM Peptidase M22, glycoprotease
SR35_RS09190	COG1199	ATP-dependent helicase activity
SR35_RS09195	COG0251	oxidation-reduction process
SR35_RS09210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SR35_RS09220	COG1760	l-serine dehydratase
SR35_RS09225	COG2200	EAL domain
SR35_RS09230	COG1253	flavin adenine dinucleotide binding
SR35_RS09240	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS09240	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS09245	COG3715	PTS system
SR35_RS09250	COG3716	PTS system mannose fructose sorbose family IID component
SR35_RS09270	COG2226	methyltransferase
SR35_RS09305	COG1414	Transcriptional regulator
SR35_RS09310	COG2814	Major facilitator Superfamily
SR35_RS09320	COG0793	Belongs to the peptidase S41A family
SR35_RS09330	COG1956	GAF domain-containing protein
SR35_RS09335	COG2995	paraquat-inducible protein a
SR35_RS09340	COG3008	intermembrane lipid transfer
SR35_RS09360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SR35_RS09375	COG1276	copper resistance
SR35_RS09380	COG2372	response to copper ion
SR35_RS09390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SR35_RS09395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SR35_RS09400	COG1770	oligopeptidase
SR35_RS09405	COG2979	Protein of unknown function (DUF533)
SR35_RS09420	COG3141	response to X-ray
SR35_RS09430	COG0800	Aldolase
SR35_RS09435	COG0129	dihydroxy-acid dehydratase activity
SR35_RS09440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SR35_RS09450	COG1737	Transcriptional regulator
SR35_RS09455	COG0469	pyruvate kinase activity
SR35_RS09460	COG1560	Kdo2-lipid A biosynthetic process
SR35_RS09465	COG0739	heme binding
SR35_RS09470	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
SR35_RS09480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SR35_RS09505	COG0217	transcriptional regulatory protein
SR35_RS09510	COG0494	nUDIX hydrolase
SR35_RS09520	COG1335	isochorismatase
SR35_RS09525	COG1801	Protein of unknown function DUF72
SR35_RS09530	COG3788	relative of glutathione S-transferase, MAPEG superfamily
SR35_RS09545	COG0243	molybdopterin cofactor binding
SR35_RS09550	COG3005	denitrification pathway
SR35_RS09560	COG3102	Protein conserved in bacteria
SR35_RS09570	COG3755	Protein conserved in bacteria
SR35_RS09580	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SR35_RS09585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
SR35_RS09590	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
SR35_RS09595	COG0745	RESPONSE REGULATOR receiver
SR35_RS09600	COG2201	protein-glutamate methylesterase activity
SR35_RS09605	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
SR35_RS09610	COG0840	transmembrane signaling receptor activity
SR35_RS09615	COG0840	transmembrane signaling receptor activity
SR35_RS09620	COG0835	chemotaxis
SR35_RS09625	COG0643	Histidine kinase
SR35_RS09625	COG2198	Histidine kinase
SR35_RS09630	COG1360	Flagellar Motor Protein
SR35_RS09635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
SR35_RS09650	COG0589	response to stress
SR35_RS09660	COG1877	trehalose-phosphatase activity
SR35_RS09665	COG1172	Belongs to the binding-protein-dependent transport system permease family
SR35_RS09670	COG1129	ABC transporter
SR35_RS09675	COG1879	ABC-type sugar transport system periplasmic component
SR35_RS09680	COG1528	Iron-storage protein
SR35_RS09700	COG1528	Iron-storage protein
SR35_RS09710	COG0814	amino acid
SR35_RS09715	COG3012	SEC-C Motif Domain Protein
SR35_RS09715	COG3318	Belongs to the UPF0149 family
SR35_RS09745	COG2197	response regulator
SR35_RS09760	COG2197	response regulator
SR35_RS09765	COG1126	abc transporter atp-binding protein
SR35_RS09770	COG0765	amino acid transport
SR35_RS09780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR35_RS09790	COG1191	sigma factor activity
SR35_RS09795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
SR35_RS09800	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
SR35_RS09805	COG1516	flagellar protein fliS
SR35_RS09815	COG0366	Alpha amylase catalytic
SR35_RS09825	COG2391	methyltransferase activity
SR35_RS09830	COG0425	Belongs to the sulfur carrier protein TusA family
SR35_RS09835	COG2135	peptidase activity
SR35_RS09840	COG0454	-acetyltransferase
SR35_RS09865	COG1766	The M ring may be actively involved in energy transduction
SR35_RS09870	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SR35_RS09875	COG1317	bacterial-type flagellum organization
SR35_RS09880	COG1157	protein secretion by the type III secretion system
SR35_RS09885	COG2882	bacterial-type flagellum organization
SR35_RS09890	COG3144	bacterial-type flagellum assembly
SR35_RS09895	COG1580	Controls the rotational direction of flagella during chemotaxis
SR35_RS09900	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SR35_RS09905	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
SR35_RS09910	COG3190	flagellar
SR35_RS09915	COG1338	Plays a role in the flagellum-specific transport system
SR35_RS09920	COG1987	bacterial-type flagellum assembly
SR35_RS09925	COG1684	flagellar biosynthetic protein fliR
SR35_RS09930	COG2197	response regulator
SR35_RS09950	COG3706	GGDEF domain
SR35_RS09955	COG5475	Uncharacterized small protein (DUF2158)
SR35_RS09960	COG2354	Protein conserved in bacteria
SR35_RS09965	COG0697	spore germination
SR35_RS09970	COG3727	T/G mismatch-specific endonuclease activity
SR35_RS09975	COG0270	DNA (cytosine-5-)-methyltransferase activity
SR35_RS09980	COG1418	mRNA catabolic process
SR35_RS10005	COG2205	protein histidine kinase activity
SR35_RS10010	COG0745	RESPONSE REGULATOR receiver
SR35_RS10015	COG2351	hydroxyisourate hydrolase activity
SR35_RS10030	COG3443	Belongs to the bacterial solute-binding protein 9 family
SR35_RS10035	COG3038	cytochrome b561
SR35_RS10060	COG1388	LysM domain
SR35_RS10060	COG1470	cell adhesion involved in biofilm formation
SR35_RS10070	COG0477	Major facilitator Superfamily
SR35_RS10075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SR35_RS10080	COG0217	transcriptional regulatory protein
SR35_RS10090	COG0534	Mate efflux family protein
SR35_RS10100	COG0583	DNA-binding transcription factor activity
SR35_RS10105	COG0583	DNA-binding transcription factor activity
SR35_RS10115	COG1376	ErfK ybiS ycfS ynhG family protein
SR35_RS10130	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
SR35_RS10135	COG3039	Transposase
SR35_RS10155	COG4771	TonB-dependent receptor
SR35_RS10165	COG3468	outer membrane autotransporter barrel domain protein
SR35_RS10175	COG2003	Belongs to the UPF0758 family
SR35_RS10215	COG1289	transmembrane transporter activity
SR35_RS10225	COG1686	Belongs to the peptidase S11 family
SR35_RS10230	COG2925	Exonuclease
SR35_RS10235	COG0425	Belongs to the sulfur carrier protein TusA family
SR35_RS10240	COG2391	methyltransferase activity
SR35_RS10245	COG0531	amino acid
SR35_RS10250	COG0583	DNA-binding transcription factor activity
SR35_RS10255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SR35_RS10260	COG4115	mRNA cleavage
SR35_RS10265	COG2161	toxin-antitoxin pair type II binding
SR35_RS10275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SR35_RS10285	COG0131	Imidazoleglycerol-phosphate dehydratase
SR35_RS10285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SR35_RS10290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SR35_RS10305	COG0140	phosphoribosyl-ATP diphosphatase activity
SR35_RS10305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SR35_RS10310	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
SR35_RS10315	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SR35_RS10320	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SR35_RS10335	COG0438	transferase activity, transferring glycosyl groups
SR35_RS10340	COG0110	maltose O-acetyltransferase activity
SR35_RS10345	COG0438	transferase activity, transferring glycosyl groups
SR35_RS10355	COG0562	UDP-galactopyranose mutase
SR35_RS10360	COG2244	polysaccharide biosynthetic process
SR35_RS10365	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
SR35_RS10370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SR35_RS10380	COG1088	dTDP-glucose 4,6-dehydratase activity
SR35_RS10385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SR35_RS10395	COG0438	transferase activity, transferring glycosyl groups
SR35_RS10400	COG2327	Polysaccharide pyruvyl transferase
SR35_RS10405	COG2244	polysaccharide biosynthetic process
SR35_RS10410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SR35_RS10415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SR35_RS10420	COG0662	Cupin 2, conserved barrel domain protein
SR35_RS10420	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
SR35_RS10425	COG0297	glycogen (starch) synthase activity
SR35_RS10430	COG1051	belongs to the nudix hydrolase family
SR35_RS10435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SR35_RS10440	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SR35_RS10445	COG0110	maltose O-acetyltransferase activity
SR35_RS10450	COG1216	Glycosyl transferase, family 2
SR35_RS10460	COG0438	transferase activity, transferring glycosyl groups
SR35_RS10465	COG1045	serine acetyltransferase
SR35_RS10470	COG0463	Glycosyl transferase, family 2
SR35_RS10475	COG0489	protein tyrosine kinase activity
SR35_RS10475	COG3206	protein involved in exopolysaccharide biosynthesis
SR35_RS10480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SR35_RS10485	COG1596	polysaccharide export
SR35_RS10490	COG1253	flavin adenine dinucleotide binding
SR35_RS10495	COG2982	Protein involved in outer membrane biogenesis
SR35_RS10505	COG0572	uridine kinase
SR35_RS10510	COG3447	MASE1 domain protein
SR35_RS10510	COG5001	Diguanylate cyclase
SR35_RS10510	COG5002	protein histidine kinase activity
SR35_RS10515	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SR35_RS10525	COG0443	Heat shock 70 kDa protein
SR35_RS10530	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
SR35_RS10535	COG3779	Protein conserved in bacteria
SR35_RS10540	COG0631	protein serine/threonine phosphatase activity
SR35_RS10545	COG4245	von Willebrand factor, type A
SR35_RS10570	COG2205	protein histidine kinase activity
SR35_RS10575	COG0745	RESPONSE REGULATOR receiver
SR35_RS10580	COG3422	double-strand break repair
SR35_RS10585	COG0826	peptidase U32
SR35_RS10615	COG2801	Transposase and inactivated derivatives
SR35_RS10625	COG1063	alcohol dehydrogenase
SR35_RS10630	COG3775	system Galactitol-specific IIC component
SR35_RS10635	COG3414	Phosphotransferase system galactitol-specific IIB component
SR35_RS10640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS10655	COG1830	Aldolase
SR35_RS10660	COG2211	Major facilitator Superfamily
SR35_RS10665	COG1397	ADP-ribosylglycohydrolase
SR35_RS10670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SR35_RS10675	COG2188	Transcriptional regulator
SR35_RS10680	COG3757	hydrolase, family 25
SR35_RS10685	COG0351	phosphomethylpyrimidine kinase
SR35_RS10700	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
SR35_RS10705	COG5455	response to cobalt ion
SR35_RS10710	COG3539	Fimbrial protein
SR35_RS10715	COG3188	usher protein
SR35_RS10720	COG3121	Chaperone
SR35_RS10725	COG3539	Fimbrial protein
SR35_RS10740	COG0489	protein tyrosine kinase activity
SR35_RS10760	COG3831	ATPase activity
SR35_RS10770	COG0714	Associated with various cellular activities
SR35_RS10775	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SR35_RS10780	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SR35_RS10785	COG4715	Zinc finger, swim domain protein
SR35_RS10790	COG4808	Protein conserved in bacteria
SR35_RS10795	COG4807	Protein conserved in bacteria
SR35_RS10800	COG3279	Response regulator of the LytR AlgR family
SR35_RS10805	COG3275	phosphorelay sensor kinase activity
SR35_RS10810	COG0789	Transcriptional regulator
SR35_RS10820	COG1174	glycine betaine transport
SR35_RS10825	COG1125	glycine betaine transport
SR35_RS10830	COG1174	glycine betaine transport
SR35_RS10835	COG1732	Glycine betaine
SR35_RS10840	COG1472	Belongs to the glycosyl hydrolase 3 family
SR35_RS10845	COG0277	FAD linked oxidase domain protein
SR35_RS10850	COG1686	Belongs to the peptidase S11 family
SR35_RS10860	COG0586	Pfam SNARE associated Golgi protein
SR35_RS10865	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS10880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SR35_RS10890	COG1346	cytolysis
SR35_RS10900	COG2949	membrane
SR35_RS10910	COG0493	'glutamate synthase
SR35_RS10915	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
SR35_RS10915	COG0167	dihydroorotate dehydrogenase activity
SR35_RS10920	COG4211	Belongs to the binding-protein-dependent transport system permease family
SR35_RS10925	COG1129	ABC transporter
SR35_RS10935	COG1129	ABC transporter
SR35_RS10940	COG1879	ABC-type sugar transport system periplasmic component
SR35_RS10945	COG1609	Transcriptional regulator
SR35_RS10955	COG2311	Membrane
SR35_RS10975	COG4771	TonB-dependent receptor
SR35_RS10980	COG0833	amino acid
SR35_RS10985	COG0583	DNA-binding transcription factor activity
SR35_RS10990	COG2855	membrane
SR35_RS11000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SR35_RS11000	COG1522	sequence-specific DNA binding
SR35_RS11005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SR35_RS11015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SR35_RS11020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SR35_RS11025	COG2313	pseudouridylate synthase activity
SR35_RS11030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SR35_RS11035	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
SR35_RS11035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS11035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS11040	COG1105	Belongs to the carbohydrate kinase PfkB family
SR35_RS11045	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS11045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS11050	COG2814	Major facilitator Superfamily
SR35_RS11065	COG0246	Mannitol dehydrogenase
SR35_RS11070	COG0523	cobalamin synthesis protein
SR35_RS11075	COG0671	phosphoesterase, PA-phosphatase related
SR35_RS11080	COG0791	NLP P60 protein
SR35_RS11085	COG2200	EAL domain
SR35_RS11090	COG4166	transmembrane transport
SR35_RS11095	COG4174	ABC transporter (Permease)
SR35_RS11100	COG4239	(ABC) transporter, permease
SR35_RS11105	COG4172	Belongs to the ABC transporter superfamily
SR35_RS11115	COG2814	Major facilitator Superfamily
SR35_RS11120	COG1187	pseudouridine synthase activity
SR35_RS11125	COG1061	Type III restriction enzyme res subunit
SR35_RS11145	COG3083	sulfuric ester hydrolase activity
SR35_RS11155	COG3468	outer membrane autotransporter barrel domain protein
SR35_RS11170	COG2197	response regulator
SR35_RS11175	COG3088	subunit of a heme lyase
SR35_RS11175	COG4235	cytochrome complex assembly
SR35_RS11180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SR35_RS11185	COG1138	Cytochrome C-type biogenesis protein
SR35_RS11195	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SR35_RS11200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SR35_RS11205	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SR35_RS11210	COG4133	protoheme IX ABC transporter activity
SR35_RS11215	COG3005	denitrification pathway
SR35_RS11220	COG3043	anaerobic respiration
SR35_RS11225	COG0348	domain, Protein
SR35_RS11230	COG0437	4 iron, 4 sulfur cluster binding
SR35_RS11240	COG3062	negative regulation of establishment of protein localization
SR35_RS11245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS11245	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS11265	COG4615	Cyclic peptide transporter
SR35_RS11270	COG3145	DNA-N1-methyladenine dioxygenase activity
SR35_RS11275	COG2169	Transcriptional regulator
SR35_RS11275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SR35_RS11280	COG1477	protein flavinylation
SR35_RS11285	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
SR35_RS11300	COG0642	Histidine kinase
SR35_RS11300	COG2198	Histidine kinase
SR35_RS11305	COG2197	response regulator
SR35_RS11310	COG0784	Response regulator, receiver
SR35_RS11310	COG2205	protein histidine kinase activity
SR35_RS11315	COG3852	Histidine kinase
SR35_RS11320	COG2204	response regulator
SR35_RS11325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SR35_RS11330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SR35_RS11335	COG2031	fatty acid transporter
SR35_RS11340	COG0183	Belongs to the thiolase family
SR35_RS11345	COG4676	Protein conserved in bacteria
SR35_RS11350	COG5445	Predicted secreted protein (DUF2300)
SR35_RS11355	COG2373	Large extracellular alpha-helical protein
SR35_RS11365	COG3234	Protein of unknown function (DUF1175)
SR35_RS11370	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
SR35_RS11375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SR35_RS11385	COG3468	outer membrane autotransporter barrel domain protein
SR35_RS11395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SR35_RS11400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SR35_RS11405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SR35_RS11410	COG3642	lipopolysaccharide core region biosynthetic process
SR35_RS11415	COG0583	DNA-binding transcription factor activity
SR35_RS11420	COG0584	glycerophosphoryl diester phosphodiesterase
SR35_RS11425	COG2271	Major facilitator Superfamily
SR35_RS11430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SR35_RS11440	COG0247	lactate metabolic process
SR35_RS11445	COG5464	transposase or invertase
SR35_RS11460	COG2271	Major facilitator Superfamily
SR35_RS11470	COG1414	Transcriptional regulator
SR35_RS11535	COG0318	PFAM AMP-dependent synthetase and ligase
SR35_RS11545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SR35_RS11560	COG1169	isochorismate synthase
SR35_RS11565	COG4575	ribosome binding
SR35_RS11570	COG2153	protein acetylation
SR35_RS11580	COG5160	protein modification by small protein removal
SR35_RS11585	COG2304	oxidoreductase activity
SR35_RS11590	COG2234	aminopeptidase activity
SR35_RS11610	COG0457	Tetratricopeptide repeat
SR35_RS11620	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SR35_RS11625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SR35_RS11635	COG0839	Belongs to the complex I subunit 6 family
SR35_RS11650	COG1034	ATP synthesis coupled electron transport
SR35_RS11655	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SR35_RS11660	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
SR35_RS11680	COG0583	DNA-binding transcription factor activity
SR35_RS11685	COG0436	Aminotransferase
SR35_RS11695	COG0490	domain, Protein
SR35_RS11695	COG0471	metal ion transport
SR35_RS11700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SR35_RS11720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SR35_RS11725	COG0280	phosphate acetyltransferase
SR35_RS11725	COG0857	belongs to the CobB CobQ family
SR35_RS11730	COG1288	antiporter activity
SR35_RS11735	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SR35_RS11740	COG0622	Phosphoesterase
SR35_RS11745	COG0625	glutathione transferase activity
SR35_RS11750	COG0625	glutathione transferase activity
SR35_RS11755	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SR35_RS11760	COG1090	epimerase
SR35_RS11765	COG5464	transposase or invertase
SR35_RS11770	COG4598	ABC transporter
SR35_RS11775	COG4160	amino acid transport
SR35_RS11780	COG4215	(ABC) transporter
SR35_RS11785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR35_RS11790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR35_RS11795	COG0163	prenyltransferase activity
SR35_RS11800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SR35_RS11805	COG1286	toxin biosynthetic process
SR35_RS11810	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
SR35_RS11815	COG0285	dihydrofolate synthase activity
SR35_RS11825	COG0586	Pfam SNARE associated Golgi protein
SR35_RS11835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SR35_RS11850	COG2814	Major facilitator Superfamily
SR35_RS11855	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SR35_RS11870	COG3101	peptidyl-lysine hydroxylation
SR35_RS11875	COG0730	response to heat
SR35_RS11890	COG2890	protein-(glutamine-N5) methyltransferase activity
SR35_RS11905	COG3539	Fimbrial protein
SR35_RS11910	COG3539	Fimbrial protein
SR35_RS11915	COG3539	Fimbrial protein
SR35_RS11920	COG3121	Chaperone
SR35_RS11930	COG3539	Fimbrial protein
SR35_RS11935	COG2062	phosphohistidine phosphatase, SixA
SR35_RS11950	COG3691	Protein conserved in bacteria
SR35_RS11955	COG2067	long-chain fatty acid transport protein
SR35_RS11965	COG2853	Lipoprotein
SR35_RS11970	COG2116	formate transmembrane transporter activity
SR35_RS11980	COG0582	viral genome integration into host DNA
SR35_RS11985	COG2246	polysaccharide biosynthetic process
SR35_RS11990	COG0463	Glycosyl transferase, family 2
SR35_RS12015	COG4725	Belongs to the MT-A70-like family
SR35_RS12025	COG1846	Transcriptional regulator
SR35_RS12035	COG5532	Uncharacterized conserved protein (DUF2303)
SR35_RS12040	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
SR35_RS12060	COG0583	DNA-binding transcription factor activity
SR35_RS12065	COG2610	gluconate transmembrane transporter activity
SR35_RS12075	COG0477	Major facilitator Superfamily
SR35_RS12080	COG1566	PFAM secretion protein HlyD family protein
SR35_RS12085	COG2197	response regulator
SR35_RS12090	COG2198	Histidine kinase
SR35_RS12090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR35_RS12090	COG0784	Response regulator, receiver
SR35_RS12090	COG2205	protein histidine kinase activity
SR35_RS12095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SR35_RS12100	COG0679	Auxin Efflux Carrier
SR35_RS12105	COG0028	Belongs to the TPP enzyme family
SR35_RS12135	COG1560	Kdo2-lipid A biosynthetic process
SR35_RS12140	COG0436	Aminotransferase
SR35_RS12145	COG3275	phosphorelay sensor kinase activity
SR35_RS12150	COG3279	Response regulator of the LytR AlgR family
SR35_RS12155	COG2207	Transcriptional regulator
SR35_RS12160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS12160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SR35_RS12160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS12165	COG1363	Peptidase, m42
SR35_RS12170	COG0006	proline dipeptidase activity
SR35_RS12175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS12180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS12210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SR35_RS12215	COG3385	transposase activity
SR35_RS12220	COG2200	EAL domain
SR35_RS12220	COG2199	diguanylate cyclase activity
SR35_RS12235	COG3415	Transposase
SR35_RS12240	COG3415	Transposase
SR35_RS12270	COG0583	DNA-binding transcription factor activity
SR35_RS12280	COG2211	Major facilitator Superfamily
SR35_RS12285	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SR35_RS12295	COG0583	DNA-binding transcription factor activity
SR35_RS12300	COG0385	Bile acid
SR35_RS12305	COG3530	Putative quorum-sensing-regulated virulence factor
SR35_RS12325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SR35_RS12330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS12335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SR35_RS12340	COG2190	(PTS) system
SR35_RS12355	COG3831	ATPase activity
SR35_RS12355	COG4884	unkown
SR35_RS12360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SR35_RS12365	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SR35_RS12370	COG4208	sulfate ABC transporter
SR35_RS12375	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SR35_RS12380	COG4150	thiosulfate binding
SR35_RS12385	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS12400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS12400	COG1263	PTS System
SR35_RS12405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SR35_RS12410	COG2837	iron assimilation
SR35_RS12425	COG0456	acetyltransferase
SR35_RS12430	COG0860	N-Acetylmuramoyl-L-alanine amidase
SR35_RS12440	COG2207	Transcriptional regulator
SR35_RS12445	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SR35_RS12450	COG4816	utilization protein
SR35_RS12460	COG4303	Ethanolamine ammonia lyase large subunit
SR35_RS12465	COG4819	ethanolamine utilization protein
SR35_RS12470	COG3192	ethanolamine utilization protein
SR35_RS12475	COG1454	alcohol dehydrogenase
SR35_RS12480	COG4820	ethanolamine utilization protein (EutJ)
SR35_RS12485	COG1012	belongs to the aldehyde dehydrogenase family
SR35_RS12490	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
SR35_RS12495	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
SR35_RS12500	COG0280	phosphate acetyltransferase
SR35_RS12505	COG4812	Cobalamin adenosyltransferase
SR35_RS12510	COG4766	ethanolamine catabolic process
SR35_RS12515	COG4917	ethanolamine utilization protein
SR35_RS12520	COG4810	utilization protein
SR35_RS12525	COG0280	phosphate acetyltransferase
SR35_RS12525	COG0281	malic enzyme
SR35_RS12530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SR35_RS12535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SR35_RS12540	COG5342	invasion associated locus B
SR35_RS12550	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS12550	COG0493	'glutamate synthase
SR35_RS12555	COG3850	Histidine kinase
SR35_RS12560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SR35_RS12570	COG1393	Belongs to the ArsC family
SR35_RS12585	COG0400	carboxylic ester hydrolase activity
SR35_RS12590	COG1444	tRNA N-acetyltransferase activity
SR35_RS12595	COG2321	neutral zinc metallopeptidase
SR35_RS12610	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
SR35_RS12620	COG2716	regulation of RNA biosynthetic process
SR35_RS12625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SR35_RS12630	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS12635	COG0651	ATP synthesis coupled electron transport
SR35_RS12640	COG0650	Formate hydrogenlyase subunit 4
SR35_RS12645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SR35_RS12650	COG4237	Hydrogenase 4 membrane
SR35_RS12655	COG0651	ATP synthesis coupled electron transport
SR35_RS12660	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SR35_RS12660	COG3261	NADH dehydrogenase
SR35_RS12665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SR35_RS12670	COG3260	NADH ubiquinone oxidoreductase 20
SR35_RS12680	COG3604	Transcriptional regulator
SR35_RS12685	COG2116	formate transmembrane transporter activity
SR35_RS12690	COG0628	permease
SR35_RS12695	COG4783	chaperone-mediated protein folding
SR35_RS12700	COG1393	Belongs to the ArsC family
SR35_RS12710	COG2233	PERMEase
SR35_RS12725	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SR35_RS12730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SR35_RS12735	COG0248	Ppx GppA phosphatase
SR35_RS12740	COG2200	EAL domain
SR35_RS12755	COG3133	Outer membrane lipoprotein
SR35_RS12770	COG0516	GMP reductase activity
SR35_RS12770	COG0517	IMP dehydrogenase activity
SR35_RS12780	COG1645	bacterial-type flagellum-dependent swarming motility
SR35_RS12790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SR35_RS12795	COG2976	Protein conserved in bacteria
SR35_RS12825	COG4953	penicillin-binding protein 1C
SR35_RS12830	COG2373	Large extracellular alpha-helical protein
SR35_RS12835	COG2897	thiosulfate sulfurtransferase activity
SR35_RS12850	COG2975	iron-sulfur cluster assembly
SR35_RS12855	COG0633	Ferredoxin
SR35_RS12875	COG0822	iron-sulfur transferase activity
SR35_RS12895	COG0483	inositol monophosphate 1-phosphatase activity
SR35_RS12900	COG1073	alpha beta
SR35_RS12905	COG3711	transcriptional antiterminator
SR35_RS12910	COG2814	Major facilitator Superfamily
SR35_RS12915	COG0583	DNA-binding transcription factor activity
SR35_RS12920	COG4638	Rieske (2fe-2S)
SR35_RS12945	COG2259	Doxx family
SR35_RS12950	COG2017	converts alpha-aldose to the beta-anomer
SR35_RS12955	COG1063	alcohol dehydrogenase
SR35_RS12960	COG1172	Belongs to the binding-protein-dependent transport system permease family
SR35_RS12965	COG1129	ABC transporter
SR35_RS12970	COG1879	ABC-type sugar transport system periplasmic component
SR35_RS12975	COG0457	Tetratricopeptide repeat
SR35_RS12980	COG1940	carbohydrate kinase activity
SR35_RS12990	COG1017	nitric oxide dioxygenase activity
SR35_RS12990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SR35_RS12995	COG0347	Belongs to the P(II) protein family
SR35_RS13000	COG2204	response regulator
SR35_RS13005	COG3170	Tfp pilus assembly protein FimV
SR35_RS13010	COG2205	protein histidine kinase activity
SR35_RS13015	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SR35_RS13015	COG0047	phosphoribosylformylglycinamidine synthase activity
SR35_RS13030	COG0560	Phosphoserine phosphatase
SR35_RS13035	COG1737	Transcriptional regulator
SR35_RS13040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS13065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
SR35_RS13085	COG0681	Belongs to the peptidase S26 family
SR35_RS13095	COG3086	response to oxidative stress
SR35_RS13100	COG3026	antisigma factor binding
SR35_RS13105	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
SR35_RS13110	COG1595	DNA-templated transcription, initiation
SR35_RS13120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SR35_RS13130	COG0513	Belongs to the DEAD box helicase family
SR35_RS13140	COG0583	DNA-binding transcription factor activity
SR35_RS13160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SR35_RS13170	COG3118	belongs to the thioredoxin family
SR35_RS13175	COG3148	PFAM DTW domain containing protein
SR35_RS13180	COG0045	succinate-CoA ligase (ADP-forming) activity
SR35_RS13180	COG1042	CoA-binding domain protein
SR35_RS13180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SR35_RS13185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SR35_RS13190	COG5544	Lipoprotein
SR35_RS13195	COG0477	Major facilitator Superfamily
SR35_RS13225	COG0542	response to heat
SR35_RS13230	COG1496	oxidoreductase activity
SR35_RS13235	COG0564	pseudouridine synthase activity
SR35_RS13240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SR35_RS13250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SR35_RS13255	COG0077	Prephenate dehydratase
SR35_RS13255	COG1605	Chorismate mutase
SR35_RS13260	COG1605	Chorismate mutase
SR35_RS13260	COG0287	Prephenate dehydrogenase
SR35_RS13265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SR35_RS13280	COG2199	diguanylate cyclase activity
SR35_RS13285	COG2885	chlorophyll binding
SR35_RS13310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SR35_RS13315	COG4137	Cytochrome C assembly protein
SR35_RS13320	COG4536	flavin adenine dinucleotide binding
SR35_RS13340	COG0497	DNA recombination
SR35_RS13345	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SR35_RS13355	COG2867	negative regulation of translational initiation
SR35_RS13365	COG0582	viral genome integration into host DNA
SR35_RS13375	COG3311	Transcriptional regulator
SR35_RS13380	COG4983	Phage plasmid primase, P4 family domain protein
SR35_RS13390	COG1204	response to ionizing radiation
SR35_RS13400	COG1479	Protein of unknown function DUF262
SR35_RS13415	COG3596	GTP binding
SR35_RS13425	COG2378	regulation of single-species biofilm formation
SR35_RS13465	COG2003	Belongs to the UPF0758 family
SR35_RS13480	COG3468	outer membrane autotransporter barrel domain protein
SR35_RS13505	COG0366	Alpha amylase catalytic
SR35_RS13510	COG0366	Alpha amylase catalytic
SR35_RS13515	COG0366	Alpha amylase catalytic
SR35_RS13525	COG0579	oxidoreductase
SR35_RS13530	COG1012	belongs to the aldehyde dehydrogenase family
SR35_RS13535	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SR35_RS13540	COG1113	amino acid transport
SR35_RS13545	COG1802	Transcriptional regulator
SR35_RS13550	COG1652	LysM domain
SR35_RS13555	COG0401	homolog of Blt101
SR35_RS13560	COG0640	Transcriptional regulator
SR35_RS13565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SR35_RS13570	COG2916	Histone family protein nucleoid-structuring protein H-NS
SR35_RS13585	COG4575	ribosome binding
SR35_RS13590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SR35_RS13600	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SR35_RS13605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SR35_RS13610	COG4175	Glycine betaine
SR35_RS13615	COG4176	ABC-type proline glycine betaine transport system permease component
SR35_RS13620	COG2113	Glycine betaine
SR35_RS13630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SR35_RS13640	COG1846	Transcriptional regulator
SR35_RS13645	COG1566	PFAM secretion protein HlyD family protein
SR35_RS13650	COG2814	Major facilitator Superfamily
SR35_RS13665	COG1238	metal cluster binding
SR35_RS13670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SR35_RS13700	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
SR35_RS13725	COG1546	Belongs to the CinA family
SR35_RS13730	COG2951	lytic endotransglycosylase activity
SR35_RS13735	COG3730	PTS system glucitol sorbitol-specific
SR35_RS13740	COG3732	PTS system glucitol sorbitol-specific
SR35_RS13745	COG3731	PTS system glucitol sorbitol-specific IIA component
SR35_RS13750	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS13755	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS13760	COG1349	DNA-binding transcription factor activity
SR35_RS13765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SR35_RS13765	COG0517	IMP dehydrogenase activity
SR35_RS13785	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SR35_RS13790	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS13795	COG1609	Transcriptional regulator
SR35_RS13800	COG1263	PTS System
SR35_RS13800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS13805	COG2723	6-phospho-beta-galactosidase activity
SR35_RS13810	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SR35_RS13820	COG3260	NADH ubiquinone oxidoreductase 20
SR35_RS13825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SR35_RS13830	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SR35_RS13830	COG3261	NADH dehydrogenase
SR35_RS13835	COG0650	Formate hydrogenlyase subunit 4
SR35_RS13840	COG0651	ATP synthesis coupled electron transport
SR35_RS13845	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS13860	COG0375	protein maturation
SR35_RS13865	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SR35_RS13870	COG0298	carbon dioxide binding
SR35_RS13875	COG0409	Hydrogenase expression formation protein
SR35_RS13880	COG0309	Hydrogenase expression formation protein (HypE)
SR35_RS13885	COG3604	Transcriptional regulator
SR35_RS13900	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SR35_RS13905	COG1349	DNA-binding transcription factor activity
SR35_RS13910	COG2084	Dehydrogenase
SR35_RS13915	COG3395	kinase activity
SR35_RS13920	COG0235	Class ii aldolase
SR35_RS13925	COG3622	Belongs to the hyi family
SR35_RS13930	COG2610	gluconate transmembrane transporter activity
SR35_RS13940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SR35_RS13945	COG1388	LysM domain
SR35_RS13945	COG4942	peptidase
SR35_RS14000	COG2234	aminopeptidase activity
SR35_RS14005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SR35_RS14010	COG1518	maintenance of DNA repeat elements
SR35_RS14025	COG1857	crispr-associated protein
SR35_RS14040	COG1203	CRISPR-associated helicase, Cas3
SR35_RS14055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SR35_RS14060	COG0720	synthase
SR35_RS14070	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
SR35_RS14075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SR35_RS14080	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SR35_RS14085	COG2086	electron transfer activity
SR35_RS14090	COG0477	Major facilitator Superfamily
SR35_RS14095	COG0277	FAD linked oxidase domain protein
SR35_RS14100	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS14105	COG2223	nitrite transmembrane transporter activity
SR35_RS14110	COG1070	Carbohydrate kinase
SR35_RS14115	COG0602	queuosine metabolic process
SR35_RS14125	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
SR35_RS14140	COG3956	TIGRFAM MazG family protein
SR35_RS14145	COG2337	Toxic component of a toxin-antitoxin (TA) module
SR35_RS14150	COG2336	PFAM SpoVT AbrB
SR35_RS14155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SR35_RS14160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SR35_RS14165	COG3437	response regulator, receiver
SR35_RS14165	COG4999	Histidine kinase
SR35_RS14165	COG3850	Histidine kinase
SR35_RS14165	COG2205	protein histidine kinase activity
SR35_RS14170	COG4948	Mandelate Racemase Muconate Lactonizing
SR35_RS14175	COG4948	Mandelate Racemase Muconate Lactonizing
SR35_RS14180	COG2271	Major facilitator Superfamily
SR35_RS14185	COG0716	FMN binding
SR35_RS14190	COG0564	pseudouridine synthase activity
SR35_RS14195	COG3098	single-species biofilm formation
SR35_RS14215	COG1611	Belongs to the LOG family
SR35_RS14220	COG0814	amino acid
SR35_RS14225	COG1760	l-serine dehydratase
SR35_RS14235	COG1454	alcohol dehydrogenase
SR35_RS14240	COG0235	Class ii aldolase
SR35_RS14245	COG0738	Major facilitator superfamily
SR35_RS14255	COG1070	Carbohydrate kinase
SR35_RS14265	COG1349	DNA-binding transcription factor activity
SR35_RS14275	COG2363	Small membrane protein
SR35_RS14280	COG0583	DNA-binding transcription factor activity
SR35_RS14290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SR35_RS14295	COG2166	iron-sulfur cluster assembly
SR35_RS14300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SR35_RS14305	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
SR35_RS14325	COG0860	N-Acetylmuramoyl-L-alanine amidase
SR35_RS14330	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SR35_RS14330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SR35_RS14335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SR35_RS14340	COG1074	ATP-dependent DNA helicase activity
SR35_RS14345	COG1025	Belongs to the peptidase M16 family
SR35_RS14350	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
SR35_RS14355	COG4967	type IV pilus modification protein PilV
SR35_RS14365	COG4795	General secretion pathway protein
SR35_RS14370	COG2165	general secretion pathway protein
SR35_RS14385	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
SR35_RS14410	COG0861	Integral membrane protein TerC family
SR35_RS14420	COG0667	Aldo Keto reductase
SR35_RS14435	COG1609	Transcriptional regulator
SR35_RS14445	COG0583	DNA-binding transcription factor activity
SR35_RS14450	COG1794	racemase activity, acting on amino acids and derivatives
SR35_RS14455	COG2814	Major facilitator Superfamily
SR35_RS14460	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS14470	COG0183	Belongs to the thiolase family
SR35_RS14475	COG0814	amino acid
SR35_RS14480	COG2771	luxR family
SR35_RS14485	COG3710	Transcriptional regulator
SR35_RS14505	COG0457	Tetratricopeptide repeat
SR35_RS14510	COG3710	Transcriptional regulator
SR35_RS14510	COG0457	Tetratricopeptide repeat
SR35_RS14525	COG2197	response regulator
SR35_RS14530	COG2197	response regulator
SR35_RS14560	COG3387	PFAM Glycoside hydrolase 15-related
SR35_RS14565	COG3387	PFAM Glycoside hydrolase 15-related
SR35_RS14575	COG4942	peptidase
SR35_RS14580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SR35_RS14585	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SR35_RS14590	COG2080	2 iron, 2 sulfur cluster binding
SR35_RS14595	COG3829	transcription factor binding
SR35_RS14600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SR35_RS14605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SR35_RS14610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SR35_RS14620	COG0549	Belongs to the carbamate kinase family
SR35_RS14625	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SR35_RS14625	COG3608	succinylglutamate desuccinylase aspartoacylase
SR35_RS14630	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SR35_RS14635	COG2068	MobA-Related Protein
SR35_RS14640	COG0493	'glutamate synthase
SR35_RS14640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS14645	COG0402	S-adenosylhomocysteine deaminase activity
SR35_RS14650	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SR35_RS14655	COG2080	2 iron, 2 sulfur cluster binding
SR35_RS14655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SR35_RS14665	COG0402	S-adenosylhomocysteine deaminase activity
SR35_RS14670	COG2252	PERMEase
SR35_RS14675	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS14680	COG0493	'glutamate synthase
SR35_RS14680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS14690	COG2233	PERMEase
SR35_RS14705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SR35_RS14715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SR35_RS14720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SR35_RS14725	COG4974	Belongs to the 'phage' integrase family
SR35_RS14730	COG0716	FMN binding
SR35_RS14740	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
SR35_RS14750	COG1272	protein, Hemolysin III
SR35_RS14760	COG2723	6-phospho-beta-galactosidase activity
SR35_RS14765	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS14785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SR35_RS14790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SR35_RS14795	COG0006	proline dipeptidase activity
SR35_RS14810	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SR35_RS14815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SR35_RS14835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SR35_RS14835	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SR35_RS14840	COG1703	isobutyryl-CoA mutase activity
SR35_RS14845	COG1024	Enoyl-CoA hydratase
SR35_RS14850	COG0427	acetyl-CoA hydrolase
SR35_RS14855	COG0583	DNA-binding transcription factor activity
SR35_RS14860	COG2968	Membrane
SR35_RS14865	COG1279	arginine transmembrane transporter activity
SR35_RS14870	COG0668	transmembrane transport
SR35_RS14875	COG0191	fructose-bisphosphate aldolase activity
SR35_RS14890	COG1072	(Pantothenic acid kinase))
SR35_RS14895	COG3722	fumarate hydratase activity
SR35_RS14900	COG1494	fructose-1,6-bisphosphatase
SR35_RS14905	COG1063	alcohol dehydrogenase
SR35_RS14910	COG2213	PTS system mannitol-specific
SR35_RS14915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS14920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SR35_RS14925	COG0501	Belongs to the peptidase M48B family
SR35_RS14935	COG1166	arginine decarboxylase activity
SR35_RS14960	COG2814	Major facilitator Superfamily
SR35_RS14970	COG2356	endonuclease I
SR35_RS14975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SR35_RS14980	COG0189	ligase activity
SR35_RS14995	COG2805	Type II/IV secretion system protein
SR35_RS15000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SR35_RS15005	COG0762	integral membrane protein
SR35_RS15015	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SR35_RS15020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SR35_RS15030	COG0252	asparaginase activity
SR35_RS15045	COG3171	Protein conserved in bacteria
SR35_RS15055	COG1194	a g-specific adenine glycosylase
SR35_RS15070	COG2211	Major facilitator Superfamily
SR35_RS15075	COG1982	Orn Lys Arg decarboxylase major
SR35_RS15080	COG1811	Na channel or pump
SR35_RS15090	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
SR35_RS15100	COG3031	protein transport across the cell outer membrane
SR35_RS15110	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SR35_RS15115	COG3064	Membrane
SR35_RS15125	COG1620	l-lactate permease
SR35_RS15130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SR35_RS15135	COG3193	protein, possibly involved in utilization of glycolate and propanediol
SR35_RS15140	COG0247	lactate metabolic process
SR35_RS15145	COG0277	FAD linked oxidase domain protein
SR35_RS15150	COG0277	FAD linked oxidase domain protein
SR35_RS15155	COG2186	Transcriptional regulator
SR35_RS15160	COG0456	acetyltransferase
SR35_RS15170	COG2244	polysaccharide biosynthetic process
SR35_RS15175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SR35_RS15180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SR35_RS15185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SR35_RS15190	COG0306	phosphate transporter
SR35_RS15195	COG0754	glutathionylspermidine amidase activity
SR35_RS15200	COG0625	glutathione transferase activity
SR35_RS15205	COG0298	carbon dioxide binding
SR35_RS15215	COG1773	rubredoxin
SR35_RS15220	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SR35_RS15225	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SR35_RS15230	COG5557	Pfam Polysulphide reductase, NrfD
SR35_RS15235	COG0437	4 iron, 4 sulfur cluster binding
SR35_RS15240	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
SR35_RS15260	COG0667	Aldo Keto reductase
SR35_RS15270	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS15275	COG0848	biopolymer transport protein
SR35_RS15280	COG0811	peptide transport
SR35_RS15290	COG0626	cystathionine gamma-synthase activity
SR35_RS15295	COG0586	Pfam SNARE associated Golgi protein
SR35_RS15300	COG2207	Transcriptional regulator
SR35_RS15310	COG1979	alcohol dehydrogenase
SR35_RS15315	COG0656	L-ascorbic acid biosynthetic process
SR35_RS15325	COG4238	major outer membrane lipoprotein
SR35_RS15330	COG1032	radical SAM domain protein
SR35_RS15335	COG2132	Multicopper oxidase
SR35_RS15340	COG0204	Acyl-transferase
SR35_RS15345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SR35_RS15350	COG4166	transmembrane transport
SR35_RS15355	COG2944	sequence-specific DNA binding
SR35_RS15365	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SR35_RS15370	COG3111	PFAM Bacterial OB fold (BOF) protein
SR35_RS15375	COG0745	RESPONSE REGULATOR receiver
SR35_RS15380	COG0642	Histidine kinase
SR35_RS15390	COG2249	NAD(P)H dehydrogenase (quinone) activity
SR35_RS15395	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SR35_RS15400	COG0187	DNA topoisomerase II activity
SR35_RS15405	COG3150	esterase
SR35_RS15410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SR35_RS15415	COG3151	Protein conserved in bacteria
SR35_RS15420	COG0494	nUDIX hydrolase
SR35_RS15425	COG1538	Outer membrane efflux protein
SR35_RS15440	COG0754	glutathionylspermidine amidase activity
SR35_RS15445	COG3384	dioxygenase
SR35_RS15465	COG2960	long-chain fatty acid transporting porin activity
SR35_RS15470	COG3539	Fimbrial protein
SR35_RS15485	COG3188	usher protein
SR35_RS15490	COG3121	Chaperone
SR35_RS15495	COG3539	Fimbrial protein
SR35_RS15505	COG1585	Membrane protein implicated in regulation of membrane protease activity
SR35_RS15510	COG2268	Band 7 protein
SR35_RS15535	COG3025	triphosphatase activity
SR35_RS15545	COG4991	sh3 domain protein
SR35_RS15560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SR35_RS15570	COG0583	DNA-binding transcription factor activity
SR35_RS15575	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SR35_RS15585	COG0471	metal ion transport
SR35_RS15595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SR35_RS15600	COG0358	DNA primase activity
SR35_RS15605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SR35_RS15620	COG2375	cellular response to nickel ion
SR35_RS15625	COG1695	Transcriptional regulator
SR35_RS15630	COG0840	transmembrane signaling receptor activity
SR35_RS15640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SR35_RS15645	COG1609	Transcriptional regulator
SR35_RS15650	COG3250	beta-galactosidase activity
SR35_RS15655	COG2731	YhcH YjgK YiaL family protein
SR35_RS15660	COG0531	amino acid
SR35_RS15670	COG3408	Glycogen debranching enzyme
SR35_RS15670	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SR35_RS15675	COG0446	pyridine nucleotide-disulphide oxidoreductase
SR35_RS15675	COG1902	pentaerythritol trinitrate reductase activity
SR35_RS15680	COG5499	transcription regulator containing HTH domain
SR35_RS15685	COG4680	protein conserved in bacteria
SR35_RS15700	COG1451	nucleotide metabolic process
SR35_RS15705	COG2949	membrane
SR35_RS15710	COG0673	inositol 2-dehydrogenase activity
SR35_RS15715	COG0861	Integral membrane protein TerC family
SR35_RS15720	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SR35_RS15730	COG2721	sulfolactate sulfo-lyase activity
SR35_RS15740	COG2271	Major facilitator Superfamily
SR35_RS15745	COG2186	Transcriptional regulator
SR35_RS15750	COG0586	Pfam SNARE associated Golgi protein
SR35_RS15760	COG1422	Protein of unknown function (DUF1090)
SR35_RS15765	COG4575	ribosome binding
SR35_RS15770	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
SR35_RS15780	COG2259	Doxx family
SR35_RS15785	COG0435	Glutathione S-transferase
SR35_RS15790	COG3152	Membrane
SR35_RS15795	COG3152	Membrane
SR35_RS15800	COG0583	DNA-binding transcription factor activity
SR35_RS15805	COG1741	Belongs to the pirin family
SR35_RS15820	COG0814	amino acid
SR35_RS15825	COG1760	l-serine dehydratase
SR35_RS15830	COG0251	oxidation-reduction process
SR35_RS15835	COG1882	Formate acetyltransferase
SR35_RS15840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SR35_RS15850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SR35_RS15855	COG0583	DNA-binding transcription factor activity
SR35_RS15875	COG1929	Belongs to the glycerate kinase type-1 family
SR35_RS15880	COG2084	Dehydrogenase
SR35_RS15890	COG2271	Major facilitator Superfamily
SR35_RS15895	COG2721	sulfolactate sulfo-lyase activity
SR35_RS15900	COG2002	toxin-antitoxin pair type II binding
SR35_RS15910	COG1349	DNA-binding transcription factor activity
SR35_RS15920	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS15930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SR35_RS15935	COG2222	sugar isomerase
SR35_RS15945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS15950	COG3715	PTS system
SR35_RS15955	COG3716	PTS system mannose fructose sorbose family IID component
SR35_RS15960	COG0363	glucosamine-6-phosphate deaminase activity
SR35_RS15965	COG3539	Fimbrial protein
SR35_RS15970	COG3121	Chaperone
SR35_RS15975	COG3188	usher protein
SR35_RS15980	COG3539	Fimbrial protein
SR35_RS15985	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SR35_RS15990	COG3107	peptidoglycan biosynthetic process
SR35_RS16005	COG2823	Periplasmic or secreted lipoprotein
SR35_RS16010	COG0701	Predicted permease
SR35_RS16015	COG0702	epimerase
SR35_RS16020	COG0693	protein deglycase activity
SR35_RS16035	COG3153	acetyltransferase
SR35_RS16040	COG3154	lipid carrier protein
SR35_RS16045	COG0826	peptidase U32
SR35_RS16050	COG0826	peptidase U32
SR35_RS16055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SR35_RS16060	COG0814	amino acid
SR35_RS16070	COG0513	Belongs to the DEAD box helicase family
SR35_RS16105	COG0195	Participates in both transcription termination and antitermination
SR35_RS16125	COG2194	sulfuric ester hydrolase activity
SR35_RS16135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SR35_RS16145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SR35_RS16150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SR35_RS16160	COG1534	Rna-binding protein
SR35_RS16165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SR35_RS16170	COG2027	D-alanyl-D-alanine carboxypeptidase
SR35_RS16180	COG0697	spore germination
SR35_RS16195	COG0142	geranyltranstransferase activity
SR35_RS16200	COG3423	Transcriptional regulator
SR35_RS16210	COG5007	Belongs to the BolA IbaG family
SR35_RS16215	COG3113	response to antibiotic
SR35_RS16220	COG2854	intermembrane phospholipid transfer
SR35_RS16225	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
SR35_RS16230	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
SR35_RS16235	COG1127	ABC transporter
SR35_RS16240	COG0530	calcium, potassium:sodium antiporter activity
SR35_RS16245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SR35_RS16245	COG0517	IMP dehydrogenase activity
SR35_RS16250	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
SR35_RS16255	COG3117	lipopolysaccharide transmembrane transporter activity
SR35_RS16260	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
SR35_RS16265	COG1137	ATPase activity
SR35_RS16270	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
SR35_RS16275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SR35_RS16290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS16295	COG0515	serine threonine protein kinase
SR35_RS16305	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
SR35_RS16310	COG0784	Response regulator, receiver
SR35_RS16310	COG2198	Histidine kinase
SR35_RS16310	COG5002	protein histidine kinase activity
SR35_RS16315	COG1242	4 iron, 4 sulfur cluster binding
SR35_RS16320	COG0067	glutamate synthase
SR35_RS16320	COG0069	glutamate synthase activity
SR35_RS16320	COG0070	glutamate synthase
SR35_RS16325	COG0493	'glutamate synthase
SR35_RS16330	COG3539	Fimbrial protein
SR35_RS16335	COG3121	Chaperone
SR35_RS16340	COG3188	usher protein
SR35_RS16360	COG3539	Fimbrial protein
SR35_RS16365	COG4804	nuclease activity
SR35_RS16370	COG2731	YhcH YjgK YiaL family protein
SR35_RS16400	COG3069	C4-dicarboxylate transmembrane transporter activity
SR35_RS16405	COG2969	positive regulation of protein catabolic process
SR35_RS16410	COG0625	glutathione transferase activity
SR35_RS16425	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
SR35_RS16430	COG3105	Protein conserved in bacteria
SR35_RS16435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SR35_RS16440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SR35_RS16460	COG2732	(Barnase) inhibitor
SR35_RS16480	COG0583	DNA-binding transcription factor activity
SR35_RS16485	COG0312	modulator of DNA gyrase
SR35_RS16490	COG3164	Protein of unknown function
SR35_RS16495	COG1530	ribonuclease E activity
SR35_RS16500	COG0424	maF-like protein
SR35_RS16505	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
SR35_RS16510	COG1792	Involved in formation and maintenance of cell shape
SR35_RS16515	COG1077	Cell shape determining protein MreB Mrl
SR35_RS16525	COG2199	diguanylate cyclase activity
SR35_RS16525	COG2200	EAL domain
SR35_RS16530	COG0604	alcohol dehydrogenase
SR35_RS16550	COG0511	ligase activity, forming carbon-carbon bonds
SR35_RS16555	COG0439	Biotin carboxylase
SR35_RS16560	COG3924	membrane
SR35_RS16565	COG4145	pantothenate transmembrane transporter activity
SR35_RS16575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SR35_RS16595	COG1309	transcriptional regulator
SR35_RS16600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SR35_RS16605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SR35_RS16620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SR35_RS16625	COG4597	amino acid ABC transporter
SR35_RS16630	COG0765	amino acid transport
SR35_RS16635	COG1126	abc transporter atp-binding protein
SR35_RS16675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
SR35_RS16695	COG0551	DNA topoisomerase type I activity
SR35_RS16705	COG0758	DNA mediated transformation
SR35_RS16725	COG0569	domain protein
SR35_RS16735	COG3036	rescue of stalled ribosome
SR35_RS16740	COG0789	Transcriptional regulator
SR35_RS16780	COG0201	protein transport
SR35_RS16870	COG0089	rRNA binding
SR35_RS16895	COG3409	Peptidoglycan-binding domain 1 protein
SR35_RS16895	COG3267	Type II secretory pathway component ExeA
SR35_RS16900	COG3031	protein transport across the cell outer membrane
SR35_RS16905	COG1450	Type ii and iii secretion system protein
SR35_RS16910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SR35_RS16915	COG1459	type II secretion system
SR35_RS16920	COG2165	general secretion pathway protein
SR35_RS16925	COG2165	general secretion pathway protein
SR35_RS16930	COG2165	general secretion pathway protein
SR35_RS16935	COG4795	General secretion pathway protein
SR35_RS16940	COG3156	type II secretion system protein K
SR35_RS16945	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
SR35_RS16950	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
SR35_RS16955	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SR35_RS16960	COG2193	ferroxidase activity
SR35_RS16965	COG2906	2 iron, 2 sulfur cluster binding
SR35_RS16970	COG3979	chitinase
SR35_RS17010	COG2964	Protein conserved in bacteria
SR35_RS17015	COG0545	Peptidyl-prolyl cis-trans isomerase
SR35_RS17025	COG1047	Peptidyl-prolyl cis-trans
SR35_RS17030	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
SR35_RS17045	COG0488	(ABC) transporter
SR35_RS17050	COG0429	hydrolase of the alpha beta-hydrolase fold
SR35_RS17060	COG3954	Phosphoribulokinase
SR35_RS17065	COG1765	OsmC-like protein
SR35_RS17075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SR35_RS17080	COG1289	transmembrane transporter activity
SR35_RS17085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SR35_RS17090	COG0512	Glutamine amidotransferase of anthranilate synthase
SR35_RS17095	COG2184	nucleotidyltransferase activity
SR35_RS17105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SR35_RS17115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SR35_RS17120	COG2146	nitrite reductase [NAD(P)H] activity
SR35_RS17125	COG2116	formate transmembrane transporter activity
SR35_RS17140	COG0531	amino acid
SR35_RS17145	COG2222	sugar isomerase
SR35_RS17150	COG1082	Xylose isomerase domain protein TIM barrel
SR35_RS17155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SR35_RS17160	COG2188	Transcriptional regulator
SR35_RS17165	COG0626	cystathionine gamma-synthase activity
SR35_RS17180	COG1735	metal-dependent hydrolase with the TIM-barrel fold
SR35_RS17185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SR35_RS17190	COG3457	Alanine racemase
SR35_RS17200	COG2188	Transcriptional regulator
SR35_RS17205	COG0180	Tryptophanyl-tRNA synthetase
SR35_RS17210	COG0546	phosphoglycolate phosphatase activity
SR35_RS17215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SR35_RS17220	COG0338	D12 class N6 adenine-specific DNA methyltransferase
SR35_RS17225	COG3266	domain, Protein
SR35_RS17240	COG4796	Type ii and iii secretion system protein
SR35_RS17255	COG3166	PFAM Fimbrial assembly family protein
SR35_RS17260	COG4972	Pilus assembly protein
SR35_RS17265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SR35_RS17270	COG0494	nUDIX hydrolase
SR35_RS17280	COG1011	Hydrolase
SR35_RS17285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SR35_RS17295	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
SR35_RS17320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SR35_RS17325	COG2183	response to ionizing radiation
SR35_RS17330	COG1918	ferrous iron import across plasma membrane
SR35_RS17335	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SR35_RS17345	COG5464	transposase or invertase
SR35_RS17355	COG1040	competence protein
SR35_RS17365	COG2610	gluconate transmembrane transporter activity
SR35_RS17370	COG1640	4-alpha-glucanotransferase
SR35_RS17375	COG0058	SHG alpha-glucan phosphorylase activity
SR35_RS17390	COG1690	Belongs to the RtcB family
SR35_RS17395	COG4650	regulator
SR35_RS17400	COG1349	DNA-binding transcription factor activity
SR35_RS17415	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SR35_RS17420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SR35_RS17425	COG0058	SHG alpha-glucan phosphorylase activity
SR35_RS17450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SR35_RS17455	COG2095	MarC family integral membrane protein
SR35_RS17460	COG2610	gluconate transmembrane transporter activity
SR35_RS17465	COG3265	gluconokinase activity
SR35_RS17470	COG1609	Transcriptional regulator
SR35_RS17475	COG1741	Belongs to the pirin family
SR35_RS17480	COG0673	inositol 2-dehydrogenase activity
SR35_RS17485	COG1247	-acetyltransferase
SR35_RS17490	COG3157	Type VI secretion system effector, Hcp
SR35_RS17510	COG0405	Gamma-glutamyltransferase
SR35_RS17520	COG0584	glycerophosphoryl diester phosphodiesterase
SR35_RS17525	COG3842	ATPase activity
SR35_RS17530	COG0395	ABC-type sugar transport system, permease component
SR35_RS17535	COG1175	transmembrane transport
SR35_RS17540	COG1653	transport
SR35_RS17550	COG0410	ABC transporter
SR35_RS17555	COG0411	ABC transporter
SR35_RS17560	COG4177	L-phenylalanine transmembrane transporter activity
SR35_RS17565	COG0559	Belongs to the binding-protein-dependent transport system permease family
SR35_RS17570	COG0683	leucine binding
SR35_RS17575	COG0456	acetyltransferase
SR35_RS17585	COG0683	leucine binding
SR35_RS17590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SR35_RS17595	COG2177	Part of the ABC transporter FtsEX involved in
SR35_RS17600	COG2884	Cell division ATP-binding protein ftsE
SR35_RS17605	COG0552	protein localization to endoplasmic reticulum
SR35_RS17610	COG0742	ribosomal rna small subunit methyltransferase
SR35_RS17615	COG3776	membrane
SR35_RS17625	COG3714	YhhN family
SR35_RS17630	COG2217	Heavy metal translocating P-type atpase
SR35_RS17640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SR35_RS17650	COG0477	Major facilitator Superfamily
SR35_RS17655	COG0628	permease
SR35_RS17660	COG2091	lysine biosynthetic process via aminoadipic acid
SR35_RS17665	COG0747	negative chemotaxis
SR35_RS17670	COG0601	transmembrane transport
SR35_RS17675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SR35_RS17680	COG0444	Belongs to the ABC transporter superfamily
SR35_RS17685	COG1124	(ABC) transporter
SR35_RS17695	COG3209	COG3209 Rhs family protein
SR35_RS17710	COG5433	transposase activity
SR35_RS17715	COG0842	Transport permease protein
SR35_RS17720	COG1129	ABC transporter
SR35_RS17720	COG0842	Transport permease protein
SR35_RS17725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SR35_RS17755	COG2081	HI0933 family
SR35_RS17760	COG0306	phosphate transporter
SR35_RS17770	COG0589	response to stress
SR35_RS17775	COG3104	oligopeptide transport
SR35_RS17785	COG0339	signal peptide processing
SR35_RS17790	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
SR35_RS17795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SR35_RS17810	COG0640	Transcriptional regulator
SR35_RS17815	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SR35_RS17820	COG1393	Belongs to the ArsC family
SR35_RS17840	COG3065	identical protein binding
SR35_RS17845	COG2197	response regulator
SR35_RS17850	COG1285	pathogenesis
SR35_RS17865	COG3247	response to pH
SR35_RS17870	COG2771	luxR family
SR35_RS17880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SR35_RS17885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SR35_RS17890	COG2207	Transcriptional regulator
SR35_RS17895	COG2207	Transcriptional regulator
SR35_RS17900	COG0076	glutamate decarboxylase activity
SR35_RS17905	COG1858	cytochrome C peroxidase
SR35_RS17915	COG2197	response regulator
SR35_RS17920	COG0583	DNA-binding transcription factor activity
SR35_RS17925	COG1295	ribonuclease BN
SR35_RS17930	COG0477	Major facilitator Superfamily
SR35_RS17935	COG2982	Protein involved in outer membrane biogenesis
SR35_RS17940	COG2200	EAL domain
SR35_RS17950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SR35_RS17955	COG0612	Peptidase, M16
SR35_RS17965	COG2200	EAL domain
SR35_RS17965	COG2199	diguanylate cyclase activity
SR35_RS17970	COG0457	Tetratricopeptide repeat
SR35_RS17970	COG3118	belongs to the thioredoxin family
SR35_RS17975	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
SR35_RS17980	COG1215	transferase activity, transferring glycosyl groups
SR35_RS17985	COG1215	transferase activity, transferring glycosyl groups
SR35_RS18010	COG2194	sulfuric ester hydrolase activity
SR35_RS18025	COG0814	amino acid
SR35_RS18030	COG4608	Belongs to the ABC transporter superfamily
SR35_RS18035	COG0444	Belongs to the ABC transporter superfamily
SR35_RS18040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SR35_RS18045	COG0601	transmembrane transport
SR35_RS18055	COG0747	negative chemotaxis
SR35_RS18070	COG2194	sulfuric ester hydrolase activity
SR35_RS18075	COG2223	nitrite transmembrane transporter activity
SR35_RS18080	COG5571	outer membrane autotransporter
SR35_RS18085	COG2818	Glycosylase
SR35_RS18090	COG0456	acetyltransferase
SR35_RS18095	COG0243	molybdopterin cofactor binding
SR35_RS18100	COG2885	chlorophyll binding
SR35_RS18115	COG2944	sequence-specific DNA binding
SR35_RS18120	COG1278	Cold shock
SR35_RS18130	COG2963	transposase activity
SR35_RS18135	COG2801	Transposase and inactivated derivatives
SR35_RS18155	COG3274	enterobacterial common antigen metabolic process
SR35_RS18160	COG4682	membrane
SR35_RS18165	COG4682	membrane
SR35_RS18170	COG1070	Carbohydrate kinase
SR35_RS18180	COG4213	ABC transporter substrate-binding protein
SR35_RS18185	COG1129	ABC transporter
SR35_RS18190	COG4214	carbohydrate transport
SR35_RS18195	COG2207	Transcriptional regulator
SR35_RS18195	COG1609	Transcriptional regulator
SR35_RS18200	COG2992	FlgJ-related protein
SR35_RS18205	COG0366	Alpha amylase catalytic
SR35_RS18210	COG3977	Valine--pyruvate aminotransferase
SR35_RS18220	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SR35_RS18225	COG1414	Transcriptional regulator
SR35_RS18235	COG2731	YhcH YjgK YiaL family protein
SR35_RS18240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
SR35_RS18245	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
SR35_RS18250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
SR35_RS18255	COG1070	Carbohydrate kinase
SR35_RS18260	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SR35_RS18265	COG3623	hexulose-6-phosphate isomerase
SR35_RS18270	COG0235	Class ii aldolase
SR35_RS18275	COG3713	MltA-interacting MipA family protein
SR35_RS18280	COG0583	DNA-binding transcription factor activity
SR35_RS18285	COG1566	PFAM secretion protein HlyD family protein
SR35_RS18300	COG1012	belongs to the aldehyde dehydrogenase family
SR35_RS18305	COG1454	alcohol dehydrogenase
SR35_RS18310	COG3276	selenocysteine insertion sequence binding
SR35_RS18320	COG0625	glutathione transferase activity
SR35_RS18330	COG1413	lyase activity
SR35_RS18335	COG3209	COG3209 Rhs family protein
SR35_RS18340	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
SR35_RS18350	COG1566	PFAM secretion protein HlyD family protein
SR35_RS18370	COG3722	fumarate hydratase activity
SR35_RS18385	COG1620	l-lactate permease
SR35_RS18390	COG2186	Transcriptional regulator
SR35_RS18400	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
SR35_RS18405	COG1045	serine acetyltransferase
SR35_RS18420	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SR35_RS18425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SR35_RS18430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SR35_RS18435	COG4942	peptidase
SR35_RS18440	COG2861	carbohydrate metabolic process
SR35_RS18445	COG1216	Glycosyl transferase, family 2
SR35_RS18455	COG0156	8-amino-7-oxononanoate synthase activity
SR35_RS18470	COG0859	PFAM glycosyl transferase family 9
SR35_RS18475	COG0859	PFAM glycosyl transferase family 9
SR35_RS18480	COG3307	-O-antigen
SR35_RS18485	COG0859	PFAM glycosyl transferase family 9
SR35_RS18495	COG3642	lipopolysaccharide core region biosynthetic process
SR35_RS18500	COG1442	glycosyl transferase family 8
SR35_RS18505	COG1442	glycosyl transferase family 8
SR35_RS18510	COG0438	transferase activity, transferring glycosyl groups
SR35_RS18515	COG4641	Protein conserved in bacteria
SR35_RS18515	COG0438	transferase activity, transferring glycosyl groups
SR35_RS18520	COG0515	serine threonine protein kinase
SR35_RS18525	COG0438	transferase activity, transferring glycosyl groups
SR35_RS18530	COG0859	PFAM glycosyl transferase family 9
SR35_RS18535	COG1519	Transferase
SR35_RS18565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SR35_RS18570	COG0756	dUTP diphosphatase activity
SR35_RS18590	COG1561	YicC-like family, N-terminal region
SR35_RS18595	COG3645	SOS response
SR35_RS18600	COG2860	membrane
SR35_RS18610	COG0194	GDP metabolic process
SR35_RS18620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SR35_RS18625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SR35_RS18630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SR35_RS18635	COG0786	glutamate:sodium symporter activity
SR35_RS18640	COG2233	PERMEase
SR35_RS18645	COG2982	Protein involved in outer membrane biogenesis
SR35_RS18650	COG1501	Belongs to the glycosyl hydrolase 31 family
SR35_RS18655	COG2211	Major facilitator Superfamily
SR35_RS18670	COG2814	Major facilitator Superfamily
SR35_RS18675	COG0697	spore germination
SR35_RS18680	COG1464	Belongs to the NlpA lipoprotein family
SR35_RS18705	COG2252	PERMEase
SR35_RS18715	COG2271	Major facilitator Superfamily
SR35_RS18720	COG2271	Major facilitator Superfamily
SR35_RS18725	COG3851	Histidine kinase
SR35_RS18730	COG2197	response regulator
SR35_RS18735	COG0440	acetolactate synthase activity
SR35_RS18740	COG0028	Belongs to the TPP enzyme family
SR35_RS18765	COG2814	Major facilitator Superfamily
SR35_RS18770	COG0641	radical SAM
SR35_RS18780	COG2149	membrane
SR35_RS18790	COG3119	arylsulfatase activity
SR35_RS18795	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SR35_RS18800	COG2207	Transcriptional regulator
SR35_RS18810	COG1263	PTS System
SR35_RS18810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS18815	COG1263	PTS System
SR35_RS18820	COG2188	Transcriptional regulator
SR35_RS18840	COG5645	(Lipo)protein
SR35_RS18845	COG0823	Involved in the tonB-independent uptake of proteins
SR35_RS18850	COG0644	oxidoreductase
SR35_RS18855	COG2271	Major facilitator Superfamily
SR35_RS18865	COG0800	Aldolase
SR35_RS18870	COG3734	2-keto-3-deoxy-galactonokinase
SR35_RS18875	COG2186	Transcriptional regulator
SR35_RS18885	COG0561	phosphatase activity
SR35_RS18890	COG3753	Protein conserved in bacteria
SR35_RS18900	COG0187	DNA topoisomerase II activity
SR35_RS18910	COG0592	DNA-directed DNA polymerase activity
SR35_RS18955	COG0814	amino acid
SR35_RS18970	COG2091	lysine biosynthetic process via aminoadipic acid
SR35_RS18975	COG0431	NADPH-dependent FMN reductase
SR35_RS18980	COG2252	PERMEase
SR35_RS18985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SR35_RS18995	COG3196	Protein conserved in bacteria
SR35_RS19000	COG0363	glucosamine-6-phosphate deaminase activity
SR35_RS19005	COG2382	esterase
SR35_RS19015	COG2723	6-phospho-beta-galactosidase activity
SR35_RS19020	COG1263	PTS System
SR35_RS19020	COG2190	(PTS) system
SR35_RS19020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS19025	COG3711	transcriptional antiterminator
SR35_RS19030	COG0704	Plays a role in the regulation of phosphate uptake
SR35_RS19035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SR35_RS19040	COG0581	inorganic phosphate transmembrane transporter activity
SR35_RS19045	COG0573	inorganic phosphate transmembrane transporter activity
SR35_RS19050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SR35_RS19055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SR35_RS19105	COG3312	ion transport
SR35_RS19120	COG0716	FMN binding
SR35_RS19125	COG1522	sequence-specific DNA binding
SR35_RS19155	COG1129	ABC transporter
SR35_RS19160	COG1172	Belongs to the binding-protein-dependent transport system permease family
SR35_RS19165	COG1879	ABC-type sugar transport system periplasmic component
SR35_RS19170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SR35_RS19175	COG1609	Transcriptional regulator
SR35_RS19180	COG0477	Major facilitator Superfamily
SR35_RS19185	COG2186	Transcriptional regulator
SR35_RS19225	COG3085	chromosome segregation
SR35_RS19230	COG0606	chelatase, subunit chli
SR35_RS19245	COG3978	acetolactate synthase activity
SR35_RS19250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SR35_RS19260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SR35_RS19265	COG0583	DNA-binding transcription factor activity
SR35_RS19275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SR35_RS19285	COG0210	DNA helicase
SR35_RS19300	COG3118	belongs to the thioredoxin family
SR35_RS19310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SR35_RS19320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SR35_RS19325	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
SR35_RS19330	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SR35_RS19335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SR35_RS19340	COG1088	dTDP-glucose 4,6-dehydratase activity
SR35_RS19345	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SR35_RS19350	COG0456	acetyltransferase
SR35_RS19355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SR35_RS19360	COG2244	polysaccharide biosynthetic process
SR35_RS19380	COG1113	amino acid transport
SR35_RS19405	COG0641	radical SAM
SR35_RS19410	COG3119	arylsulfatase activity
SR35_RS19415	COG3071	HemY protein
SR35_RS19420	COG2959	enzyme of heme biosynthesis
SR35_RS19425	COG1587	Uroporphyrinogen-III synthase
SR35_RS19435	COG3072	Adenylate cyclase
SR35_RS19445	COG5567	small periplasmic lipoprotein
SR35_RS19455	COG3159	Protein conserved in bacteria
SR35_RS19465	COG1011	Hydrolase
SR35_RS19470	COG0210	DNA helicase
SR35_RS19475	COG3698	Phosphodiester glycosidase
SR35_RS19485	COG0598	Magnesium transport protein CorA
SR35_RS19500	COG2962	Rard protein
SR35_RS19505	COG2050	protein possibly involved in aromatic compounds catabolism
SR35_RS19510	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
SR35_RS19515	COG0514	ATP-dependent DNA helicase (RecQ)
SR35_RS19520	COG1280	lysine exporter protein (LysE YggA)
SR35_RS19525	COG1280	lysine exporter protein (LysE YggA)
SR35_RS19530	COG2267	carboxylic ester hydrolase activity
SR35_RS19535	COG0561	phosphatase activity
SR35_RS19540	COG0697	spore germination
SR35_RS19545	COG0583	DNA-binding transcription factor activity
SR35_RS19555	COG0412	Dienelactone hydrolase
SR35_RS19560	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SR35_RS19565	COG1322	Protein conserved in bacteria
SR35_RS19575	COG3165	ubiquinone biosynthetic process from chorismate
SR35_RS19585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SR35_RS19590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SR35_RS19595	COG0805	protein transport
SR35_RS19600	COG0084	hydrolase, TatD family'
SR35_RS19605	COG0250	Participates in transcription elongation, termination and antitermination
SR35_RS19610	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SR35_RS19615	COG0543	2 iron, 2 sulfur cluster binding
SR35_RS19620	COG0183	Belongs to the thiolase family
SR35_RS19635	COG1739	Uncharacterized protein family UPF0029
SR35_RS19640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SR35_RS19645	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
SR35_RS19675	COG1763	Mo-molybdopterin cofactor biosynthetic process
SR35_RS19680	COG0746	molybdenum cofactor guanylyltransferase activity
SR35_RS19685	COG3084	Protein conserved in bacteria
SR35_RS19690	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
SR35_RS19695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SR35_RS19700	COG5339	Protein conserved in bacteria
SR35_RS19705	COG0204	Acyl-transferase
SR35_RS19715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SR35_RS19715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SR35_RS19730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SR35_RS19740	COG2204	response regulator
SR35_RS19745	COG3852	Histidine kinase
SR35_RS19750	COG0174	glutamine synthetase
SR35_RS19760	COG1217	gtp-binding protein TYPA
SR35_RS19765	COG2188	Transcriptional regulator
SR35_RS19770	COG1082	Xylose isomerase domain protein TIM barrel
SR35_RS19775	COG2271	Major facilitator Superfamily
SR35_RS19780	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SR35_RS19785	COG2211	Major facilitator Superfamily
SR35_RS19790	COG2211	Major facilitator Superfamily
SR35_RS19795	COG1501	Belongs to the glycosyl hydrolase 31 family
SR35_RS19800	COG2017	converts alpha-aldose to the beta-anomer
SR35_RS19805	COG2942	2-epimerase
SR35_RS19810	COG3684	Belongs to the aldolase LacD family
SR35_RS19815	COG2084	Dehydrogenase
SR35_RS19820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SR35_RS19825	COG1349	DNA-binding transcription factor activity
SR35_RS19830	COG1011	Hydrolase
SR35_RS19845	COG0456	acetyltransferase
SR35_RS19850	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SR35_RS19855	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
SR35_RS19870	COG2864	formate dehydrogenase
SR35_RS19875	COG0437	4 iron, 4 sulfur cluster binding
SR35_RS19880	COG0243	molybdopterin cofactor binding
SR35_RS19880	COG3383	formate dehydrogenase (NAD+) activity
SR35_RS19885	COG3383	formate dehydrogenase (NAD+) activity
SR35_RS19885	COG0243	molybdopterin cofactor binding
SR35_RS19900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS19900	COG3711	transcriptional antiterminator
SR35_RS19905	COG1363	Peptidase, m42
SR35_RS19910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS19910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS19915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS19960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SR35_RS19975	COG2258	MOSC domain
SR35_RS19980	COG2205	protein histidine kinase activity
SR35_RS19985	COG0745	RESPONSE REGULATOR receiver
SR35_RS19990	COG3678	ATP-independent chaperone mediated protein folding
SR35_RS20005	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
SR35_RS20025	COG3152	Membrane
SR35_RS20030	COG3691	Protein conserved in bacteria
SR35_RS20035	COG0589	response to stress
SR35_RS20040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SR35_RS20045	COG1494	fructose-1,6-bisphosphatase
SR35_RS20055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SR35_RS20070	COG1575	Belongs to the MenA family. Type 1 subfamily
SR35_RS20085	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SR35_RS20090	COG1609	Transcriptional regulator
SR35_RS20105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SR35_RS20115	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
SR35_RS20125	COG0626	cystathionine gamma-synthase activity
SR35_RS20130	COG0527	aspartate kinase activity
SR35_RS20130	COG0460	homoserine dehydrogenase
SR35_RS20140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SR35_RS20150	COG0697	spore germination
SR35_RS20155	COG3738	Protein conserved in bacteria
SR35_RS20165	COG0371	Dehydrogenase
SR35_RS20170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SR35_RS20175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SR35_RS20175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS20175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS20180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS20185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS20190	COG1882	Formate acetyltransferase
SR35_RS20195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SR35_RS20200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SR35_RS20205	COG2207	Transcriptional regulator
SR35_RS20210	COG2194	sulfuric ester hydrolase activity
SR35_RS20230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SR35_RS20245	COG0583	DNA-binding transcription factor activity
SR35_RS20270	COG4206	TonB-dependent receptor
SR35_RS20300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SR35_RS20305	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SR35_RS20305	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SR35_RS20345	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SR35_RS20350	COG0250	Participates in transcription elongation, termination and antitermination
SR35_RS20390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SR35_RS20400	COG2104	thiamine diphosphate biosynthetic process
SR35_RS20405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SR35_RS20440	COG3068	Protein conserved in bacteria
SR35_RS20455	COG3678	ATP-independent chaperone mediated protein folding
SR35_RS20460	COG4191	Histidine kinase
SR35_RS20465	COG2204	response regulator
SR35_RS20470	COG0151	Belongs to the GarS family
SR35_RS20515	COG0456	acetyltransferase
SR35_RS20525	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SR35_RS20530	COG2224	Isocitrate lyase
SR35_RS20545	COG1414	Transcriptional regulator
SR35_RS20550	COG1410	methionine synthase
SR35_RS20550	COG0646	methionine synthase
SR35_RS20555	COG1283	sodium-dependent phosphate transmembrane transporter activity
SR35_RS20565	COG1187	pseudouridine synthase activity
SR35_RS20575	COG0527	aspartate kinase activity
SR35_RS20600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SR35_RS20620	COG0477	Major facilitator Superfamily
SR35_RS20620	COG2814	Major facilitator Superfamily
SR35_RS20625	COG3833	ABC-type maltose transport systems, permease component
SR35_RS20630	COG1175	transmembrane transport
SR35_RS20635	COG2182	Extracellular solute-binding protein
SR35_RS20645	COG3842	ATPase activity
SR35_RS20665	COG1357	PFAM Pentapeptide repeats (8 copies)
SR35_RS20685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SR35_RS20695	COG0534	Mate efflux family protein
SR35_RS20700	COG3237	CsbD-like
SR35_RS20705	COG0735	belongs to the Fur family
SR35_RS20720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SR35_RS20730	COG0604	alcohol dehydrogenase
SR35_RS20735	COG0305	Participates in initiation and elongation during chromosome replication
SR35_RS20740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SR35_RS20745	COG1448	Aminotransferase
SR35_RS20755	COG3700	Belongs to the class B bacterial acid phosphatase family
SR35_RS20760	COG0432	Pfam Uncharacterised protein family UPF0047
SR35_RS20765	COG2315	Protein conserved in bacteria
SR35_RS20770	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SR35_RS20775	COG0629	single-stranded DNA binding
SR35_RS20785	COG4943	cyclic-guanylate-specific phosphodiesterase activity
SR35_RS20790	COG2207	Transcriptional regulator
SR35_RS20795	COG0789	Transcriptional regulator
SR35_RS20800	COG2252	PERMEase
SR35_RS20805	COG0025	NhaP-type Na H and K H
SR35_RS20810	COG1357	PFAM Pentapeptide repeats (8 copies)
SR35_RS20820	COG3162	membrane
SR35_RS20825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SR35_RS20835	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
SR35_RS20840	COG0437	4 iron, 4 sulfur cluster binding
SR35_RS20845	COG3301	Polysulphide reductase, NrfD
SR35_RS20850	COG1138	Cytochrome C-type biogenesis protein
SR35_RS20855	COG3088	subunit of a heme lyase
SR35_RS20860	COG4235	cytochrome complex assembly
SR35_RS20865	COG1301	dicarboxylic acid transport
SR35_RS20870	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
SR35_RS20875	COG3383	formate dehydrogenase (NAD+) activity
SR35_RS20880	COG3383	formate dehydrogenase (NAD+) activity
SR35_RS20885	COG1538	Outer membrane efflux protein
SR35_RS20890	COG1289	transmembrane transporter activity
SR35_RS20895	COG1566	PFAM secretion protein HlyD family protein
SR35_RS20905	COG2015	COG2015, Alkyl sulfatase and related hydrolases
SR35_RS20910	COG1940	carbohydrate kinase activity
SR35_RS20915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SR35_RS20920	COG1172	Belongs to the binding-protein-dependent transport system permease family
SR35_RS20925	COG1129	ABC transporter
SR35_RS20930	COG1879	ABC-type sugar transport system periplasmic component
SR35_RS20935	COG1737	Transcriptional regulator
SR35_RS20940	COG0698	ribose 5-phosphate isomerase
SR35_RS20950	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SR35_RS20955	COG0456	acetyltransferase
SR35_RS20960	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SR35_RS20965	COG3454	Phosphonate metabolism
SR35_RS20970	COG4778	phosphonate C-P lyase system protein PhnL
SR35_RS20975	COG4107	phosphonate C-P lyase system protein PhnK
SR35_RS20980	COG3627	carbon phosphorus lyase activity
SR35_RS20985	COG3626	phosphonate metabolism
SR35_RS20990	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
SR35_RS20995	COG3624	Phosphonate C-P lyase system protein PhnG
SR35_RS21000	COG2188	Transcriptional regulator
SR35_RS21010	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SR35_RS21015	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SR35_RS21020	COG2764	glyoxalase bleomycin resistance protein dioxygenase
SR35_RS21025	COG2824	Alkylphosphonate utilization operon protein PhnA
SR35_RS21030	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SR35_RS21040	COG0477	Major facilitator Superfamily
SR35_RS21050	COG0642	Histidine kinase
SR35_RS21055	COG0745	RESPONSE REGULATOR receiver
SR35_RS21060	COG2194	sulfuric ester hydrolase activity
SR35_RS21065	COG0531	amino acid
SR35_RS21070	COG2207	Transcriptional regulator
SR35_RS21075	COG1982	Orn Lys Arg decarboxylase major
SR35_RS21080	COG2169	Transcriptional regulator
SR35_RS21090	COG1486	melibiose metabolic process
SR35_RS21095	COG2211	Major facilitator Superfamily
SR35_RS21100	COG3647	Membrane
SR35_RS21105	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SR35_RS21105	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SR35_RS21110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SR35_RS21120	COG4565	transcriptional regulatory protein
SR35_RS21125	COG3290	protein histidine kinase activity
SR35_RS21130	COG3592	Divergent 4Fe-4S mono-cluster
SR35_RS21135	COG2388	GCN5-related N-acetyl-transferase
SR35_RS21155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SR35_RS21160	COG3104	oligopeptide transport
SR35_RS21165	COG1982	Orn Lys Arg decarboxylase major
SR35_RS21170	COG0531	amino acid
SR35_RS21175	COG3710	Transcriptional regulator
SR35_RS21185	COG1309	transcriptional regulator
SR35_RS21190	COG4232	protein-disulfide reductase activity
SR35_RS21210	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SR35_RS21215	COG1027	Aspartate ammonia-lyase
SR35_RS21220	COG3030	protein affecting phage T7 exclusion by the F plasmid
SR35_RS21225	COG0531	amino acid
SR35_RS21250	COG1509	lysine 2,3-aminomutase activity
SR35_RS21260	COG5510	response to toxic substance
SR35_RS21265	COG5510	response to toxic substance
SR35_RS21270	COG2076	Multidrug Resistance protein
SR35_RS21275	COG3040	lipid binding
SR35_RS21280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SR35_RS21295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SR35_RS21300	COG1053	succinate dehydrogenase
SR35_RS21310	COG0531	amino acid
SR35_RS21325	COG3264	Mechanosensitive ion channel
SR35_RS21325	COG1511	domain protein
SR35_RS21360	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SR35_RS21365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SR35_RS21365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SR35_RS21370	COG0802	atpase or kinase
SR35_RS21375	COG0860	N-Acetylmuramoyl-L-alanine amidase
SR35_RS21395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SR35_RS21400	COG0330	HflC and HflK could
SR35_RS21405	COG0330	HflC and HflK could
SR35_RS21410	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
SR35_RS21425	COG0557	exoribonuclease II activity
SR35_RS21430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SR35_RS21435	COG3789	protein conserved in bacteria
SR35_RS21440	COG1842	Phage shock protein A
SR35_RS21450	COG3766	membrane
SR35_RS21455	COG5463	Belongs to the UPF0441 family
SR35_RS21460	COG0754	glutathionylspermidine amidase activity
SR35_RS21465	COG1960	acyl-CoA dehydrogenase activity
SR35_RS21475	COG3650	response to hydrogen peroxide
SR35_RS21480	COG1073	alpha beta
SR35_RS21495	COG3037	sugar-specific permease SgaT UlaA
SR35_RS21500	COG3414	Phosphotransferase system galactitol-specific IIB component
SR35_RS21505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS21545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SR35_RS21560	COG1309	transcriptional regulator
SR35_RS21565	COG3061	Opacity-associated protein A
SR35_RS21570	COG0545	Peptidyl-prolyl cis-trans isomerase
SR35_RS21575	COG1113	amino acid transport
SR35_RS21585	COG0697	spore germination
SR35_RS21590	COG0702	epimerase
SR35_RS21595	COG1733	regulation of RNA biosynthetic process
SR35_RS21600	COG0737	Belongs to the 5'-nucleotidase family
SR35_RS21605	COG1218	3'(2'),5'-bisphosphate nucleotidase
SR35_RS21615	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
SR35_RS21625	COG1253	flavin adenine dinucleotide binding
SR35_RS21640	COG0729	surface antigen
SR35_RS21650	COG2105	PFAM AIG2 family protein
SR35_RS21655	COG2336	PFAM SpoVT AbrB
SR35_RS21660	COG2337	Toxic component of a toxin-antitoxin (TA) module
SR35_RS21665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SR35_RS21670	COG1879	ABC-type sugar transport system periplasmic component
SR35_RS21675	COG1129	ABC transporter
SR35_RS21680	COG1172	Belongs to the binding-protein-dependent transport system permease family
SR35_RS21685	COG1172	Belongs to the binding-protein-dependent transport system permease family
SR35_RS21695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SR35_RS21705	COG0312	modulator of DNA gyrase
SR35_RS21710	COG3783	Cytochrome b(562)
SR35_RS21715	COG0602	queuosine metabolic process
SR35_RS21720	COG1328	CTP reductase activity
SR35_RS21725	COG0366	Alpha amylase catalytic
SR35_RS21730	COG1263	PTS System
SR35_RS21730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SR35_RS21735	COG1609	Transcriptional regulator
SR35_RS21740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SR35_RS21745	COG0251	oxidation-reduction process
SR35_RS21770	COG0251	oxidation-reduction process
SR35_RS21775	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS21780	COG1309	transcriptional regulator
SR35_RS21785	COG2731	YhcH YjgK YiaL family protein
SR35_RS21795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SR35_RS21800	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
SR35_RS21805	COG0456	acetyltransferase
SR35_RS21810	COG4269	membrane
SR35_RS21815	COG0525	valine-tRNA ligase activity
SR35_RS21820	COG2927	DNA polymerase III (CHI subunit)
SR35_RS21830	COG0795	lipopolysaccharide-transporting ATPase activity
SR35_RS21835	COG0795	lipopolysaccharide-transporting ATPase activity
SR35_RS21840	COG0433	COG0433 Predicted ATPase
SR35_RS21845	COG1609	Transcriptional regulator
SR35_RS21850	COG2610	gluconate transmembrane transporter activity
SR35_RS21855	COG1028	Short-chain dehydrogenase reductase Sdr
SR35_RS21860	COG1063	alcohol dehydrogenase
SR35_RS21865	COG3265	gluconokinase activity
SR35_RS21870	COG1064	alcohol dehydrogenase
SR35_RS21880	COG0582	viral genome integration into host DNA
SR35_RS21905	COG3385	transposase activity
SR35_RS21910	COG2814	Major facilitator Superfamily
SR35_RS21915	COG0673	inositol 2-dehydrogenase activity
SR35_RS21945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SR35_RS21965	COG2085	NADP oxidoreductase coenzyme F420-dependent
SR35_RS21970	COG1120	ATPase activity
SR35_RS21975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SR35_RS21980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SR35_RS21985	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SR35_RS21990	COG4772	TonB-dependent receptor
SR35_RS21995	COG3712	iron ion homeostasis
SR35_RS22000	COG1595	DNA-templated transcription, initiation
SR35_RS22035	COG1349	DNA-binding transcription factor activity
SR35_RS22040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SR35_RS22045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SR35_RS22050	COG0434	BtpA family
SR35_RS22055	COG3775	system Galactitol-specific IIC component
SR35_RS22060	COG3414	Phosphotransferase system galactitol-specific IIB component
SR35_RS22065	COG1363	Peptidase, m42
SR35_RS22070	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SR35_RS22075	COG3153	acetyltransferase
SR35_RS22105	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
SR35_RS22110	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
SR35_RS22125	COG0582	viral genome integration into host DNA
SR35_RS22135	COG4974	Belongs to the 'phage' integrase family
SR35_RS22145	COG3539	Fimbrial protein
SR35_RS22150	COG3539	Fimbrial protein
SR35_RS22155	COG3121	Chaperone
SR35_RS22160	COG3188	usher protein
SR35_RS22165	COG3539	Fimbrial protein
SR35_RS22170	COG3539	Fimbrial protein
SR35_RS22175	COG3539	Fimbrial protein
SR35_RS22180	COG2610	gluconate transmembrane transporter activity
SR35_RS22195	COG0246	Mannitol dehydrogenase
SR35_RS22205	COG2186	Transcriptional regulator
SR35_RS22230	COG0583	DNA-binding transcription factor activity
SR35_RS22235	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SR35_RS22240	COG0700	Nucleoside recognition
SR35_RS22245	COG3366	ferrous iron transmembrane transporter activity
SR35_RS22255	COG0477	Major facilitator Superfamily
SR35_RS22260	COG3204	pilus organization
SR35_RS22270	COG1924	4 iron, 4 sulfur cluster binding
SR35_RS22275	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
SR35_RS22280	COG2733	membrane
SR35_RS22285	COG2814	Major facilitator Superfamily
SR35_RS22305	COG2368	4-hydroxyphenylacetate
SR35_RS22325	COG3971	2-oxopent-4-enoate hydratase activity
SR35_RS22335	COG3384	dioxygenase
SR35_RS22340	COG1012	belongs to the aldehyde dehydrogenase family
SR35_RS22345	COG0179	Fumarylacetoacetate (FAA) hydrolase
SR35_RS22350	COG1846	Transcriptional regulator
SR35_RS22355	COG0840	transmembrane signaling receptor activity
SR35_RS22360	COG2271	Major facilitator Superfamily
SR35_RS22370	COG1063	alcohol dehydrogenase
SR35_RS22385	COG1484	DNA-dependent DNA replication
SR35_RS22400	COG2966	Psort location CytoplasmicMembrane, score
SR35_RS22405	COG2197	response regulator
SR35_RS22410	COG2197	response regulator
SR35_RS22415	COG4114	ferric iron reductase
SR35_RS22445	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
SR35_RS22450	COG0456	acetyltransferase
SR35_RS22455	COG1011	Hydrolase
SR35_RS22465	COG2823	Periplasmic or secreted lipoprotein
SR35_RS22475	COG4667	esterase of the alpha-beta hydrolase superfamily
SR35_RS22480	COG0084	hydrolase, TatD family'
SR35_RS22485	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SR35_RS22490	COG1328	CTP reductase activity
SR35_RS22530	COG3726	membrane protein affecting hemolysin expression
SR35_RS22535	COG0560	Phosphoserine phosphatase
SR35_RS22540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SR35_RS22545	COG1056	cytidyltransferase-related domain
SR35_RS22545	COG3172	ATPase kinase involved in NAD metabolism
SR35_RS22555	COG0488	(ABC) transporter
SR35_RS22560	COG0741	lytic transglycosylase activity
SR35_RS22580	COG2207	Transcriptional regulator
SR35_RS22580	COG3708	Transcriptional regulator
SR35_RS22585	COG3045	CreA protein
SR35_RS22590	COG0745	RESPONSE REGULATOR receiver
SR35_RS22595	COG2205	protein histidine kinase activity
SR35_RS22600	COG4452	Inner membrane protein CreD
SR35_RS22605	COG0745	RESPONSE REGULATOR receiver
SR35_RS22615	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA