locus-tag class description HZR83_RS00020 ENOG4105CHF Glutathione S-transferase HZR83_RS00025 ENOG4108VBZ doxx family HZR83_RS00030 ENOG4105YJD HZR83_RS00035 ENOG41090KG Inner membrane protein YqjE HZR83_RS00040 ENOG4105NE1 Conserved Protein HZR83_RS00045 ENOG4105WAY exported protein HZR83_RS00050 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HZR83_RS00055 ENOG4106W5V Membrane HZR83_RS00060 ENOG4107YCY Transcriptional regulator HZR83_RS00065 ENOG4105DPW Major facilitator superfamily MFS_1 HZR83_RS00075 ENOG4105CTX dehydratase HZR83_RS00080 ENOG4105P66 Membrane HZR83_RS00085 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HZR83_RS00090 ENOG4105DU1 integral membrane protein, terc HZR83_RS00095 ENOG4105EE0 oxidoreductase HZR83_RS00100 ENOG4108UB4 uncharacterized protein ygjQ HZR83_RS00105 ENOG4108VKG metal-dependent hydrolase HZR83_RS00115 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HZR83_RS00120 ENOG4107WCA isomerase HZR83_RS00125 ENOG4107W6W Conserved Protein HZR83_RS00130 ENOG4105E5D amino acid HZR83_RS00135 ENOG4105FK9 beta-D-galactosidase beta subunit HZR83_RS00140 ENOG4105CNT hydrolase family 2 HZR83_RS00145 ENOG4105CQ4 Transcriptional regulator HZR83_RS00150 ENOG4108Y51 tRNA-binding protein HZR83_RS00160 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HZR83_RS00165 ENOG4105NTW Transcriptional regulator HZR83_RS00170 ENOG4105Q26 Siderophore-interacting protein HZR83_RS00200 ENOG410693A DNA-binding protein HZR83_RS00205 ENOG4105JXR Protein of unknown function (DUF3296) HZR83_RS00245 ENOG4105C5Y PTS System HZR83_RS00260 ENOG4105D7K pfkb domain protein HZR83_RS00280 ENOG4105EKQ RNA-directed DNA polymerase HZR83_RS00300 ENOG4105CXG d-lactate dehydrogenase HZR83_RS00305 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HZR83_RS00310 ENOG4107QR9 Iron-sulfur cluster binding protein HZR83_RS00315 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HZR83_RS00325 ENOG4105F2I Transposase HZR83_RS00335 ENOG41082EK Restriction modification system DNA (Specificity HZR83_RS00350 ENOG4105F4K antigen 43 HZR83_RS00355 ENOG4106H6R UPF0380 protein HZR83_RS00360 ENOG4105MFG Antirestriction protein HZR83_RS00365 ENOG4108YGG dna repair protein HZR83_RS00375 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HZR83_RS00410 ENOG4105VNT transposase (IS4 family) protein HZR83_RS00415 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HZR83_RS00420 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HZR83_RS00430 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HZR83_RS00435 ENOG4107QPK )-transporter HZR83_RS00440 ENOG4107GFK fumarate HZR83_RS00445 ENOG4106DSS Tartrate dehydratase subunit alpha HZR83_RS00450 ENOG4105EJC lysr family transcriptional regulator HZR83_RS00460 ENOG4107ZVW dihydroneopterin aldolase HZR83_RS00475 ENOG4106MWK domain protein HZR83_RS00480 ENOG4105I7R Adenylate cyclase HZR83_RS00485 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HZR83_RS00505 ENOG4107S78 Band 7 protein HZR83_RS00510 ENOG4105PV3 Inner membrane protein yqiJ HZR83_RS00520 ENOG4108MY7 Fimbrial HZR83_RS00525 ENOG4108TTM chaperone HZR83_RS00535 ENOG4105H8W Fimbrial protein HZR83_RS00540 ENOG4105W0Z cytoplasmic protein HZR83_RS00560 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HZR83_RS00565 ENOG4106032 Glutathionylspermidine synthase HZR83_RS00575 ENOG4105DFG type I secretion outer membrane protein HZR83_RS00580 ENOG41087AY ADP-Ribose pyrophosphatase HZR83_RS00585 ENOG4108SX3 cytoplasmic protein HZR83_RS00590 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HZR83_RS00595 ENOG4105IPS esterase HZR83_RS00600 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HZR83_RS00605 ENOG4105VRH Antibiotic biosynthesis monooxygenase HZR83_RS00610 ENOG4105NF4 modulator of drug activity HZR83_RS00615 ENOG4107DEU Inner membrane protein YgiZ HZR83_RS00620 ENOG4105DHQ Histidine kinase HZR83_RS00625 ENOG4105XJC Two component transcriptional regulator (Winged helix family HZR83_RS00630 ENOG4105H4F exported protein HZR83_RS00635 ENOG4105F4I Transcriptional regulator HZR83_RS00640 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation HZR83_RS00645 ENOG4105WJ3 XRE family Transcriptional regulator HZR83_RS00650 ENOG4108J59 Extracellular solute-binding protein, family 5 HZR83_RS00655 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HZR83_RS00660 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HZR83_RS00665 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HZR83_RS00670 ENOG4105CCT upf0313 protein HZR83_RS00680 ENOG4105ZKC Conserved Protein HZR83_RS00685 ENOG4105CV8 reductase HZR83_RS00690 ENOG4108I6A alcohol dehydrogenase HZR83_RS00695 ENOG4105CF7 AraC family transcriptional regulator HZR83_RS00700 ENOG4108K81 inner membrane protein YghB HZR83_RS00705 ENOG4105C28 cystathionine HZR83_RS00710 ENOG4105CWK Biopolymer transport protein, ExbB HZR83_RS00715 ENOG4108ZZF transport protein (ExbD) HZR83_RS00720 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HZR83_RS00730 ENOG4105CPC Aldo Keto reductase HZR83_RS00740 ENOG410900S Protein of unknown function (DUF2623) HZR83_RS00745 ENOG4105E3S small subunit HZR83_RS00750 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HZR83_RS00755 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HZR83_RS00760 ENOG4105DPX Hydrogenase, large subunit HZR83_RS00765 ENOG4108USZ hydrogenase HZR83_RS00770 ENOG4108WGS hydrogenase 2-specific chaperone HZR83_RS00780 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HZR83_RS00785 ENOG4105CYM Glutathione S-transferase HZR83_RS00790 ENOG4106032 Glutathionylspermidine synthase HZR83_RS00795 ENOG4105CJ3 phosphate transporter HZR83_RS00800 ENOG4108GH0 ATP-binding protein yghT HZR83_RS00805 ENOG4108NDC ATP-binding protein yghS HZR83_RS00810 ENOG4106FPV ATP-binding protein YghR HZR83_RS00820 ENOG4108BUD transposase HZR83_RS00830 ENOG4105DHJ ABC, transporter HZR83_RS00835 ENOG4105FEU K -dependent Na -Ca exchanger HZR83_RS00840 ENOG4105C2X Arabinose 5-phosphate isomerase HZR83_RS00845 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HZR83_RS00850 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HZR83_RS00855 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HZR83_RS00860 ENOG4108IUZ ABC transporter HZR83_RS00865 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HZR83_RS00870 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HZR83_RS00875 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HZR83_RS00885 ENOG41080Z8 PHOSPHOCARRIER protein HZR83_RS00890 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HZR83_RS00900 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HZR83_RS00905 ENOG4105BZU Histidine kinase HZR83_RS00910 ENOG4105N5T Radical SAM Protein HZR83_RS00915 ENOG4105CBC glutamate synthase HZR83_RS00920 ENOG4105BZ8 glutamate synthase HZR83_RS00925 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon HZR83_RS00930 ENOG4108S1B Periplasmic chaperone protein HZR83_RS00935 ENOG4105E6S usher protein( HZR83_RS00945 ENOG4105UMR response to DNA damage stimulus HZR83_RS00960 ENOG4105DFS Conserved Protein HZR83_RS00965 ENOG4108R66 Conserved Protein HZR83_RS00970 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HZR83_RS00980 ENOG4105JHE Major Facilitator Superfamily HZR83_RS00990 ENOG4108QBF Transcriptional regulator HZR83_RS00995 ENOG4105CEE C4-dicarboxylate transporter HZR83_RS01000 ENOG4105KB2 stringent starvation protein b HZR83_RS01005 ENOG4107MKT Stringent starvation protein a HZR83_RS01020 ENOG4105D6Z AFG1 family ATPase HZR83_RS01025 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HZR83_RS01030 ENOG4105C0H protease HZR83_RS01035 ENOG4105C0H protease HZR83_RS01050 ENOG4105RID UPF0379 protein yhcN HZR83_RS01055 ENOG4105UNR (Barnase) inhibitor HZR83_RS01070 ENOG4105ZQC membrane protein AaeX HZR83_RS01075 ENOG4105CR8 Transcriptional regulator HZR83_RS01080 ENOG4105D1U peptidase U62 modulator of DNA gyrase HZR83_RS01085 ENOG4105QD6 exported protein HZR83_RS01090 ENOG4105C03 ribonuclease HZR83_RS01095 ENOG4108Z03 MAF-like protein HZR83_RS01100 ENOG4105VQ7 Rod shape-determining protein MreD HZR83_RS01105 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HZR83_RS01115 ENOG41062P1 Diguanylate cyclase phosphodiesterase HZR83_RS01120 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HZR83_RS01125 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HZR83_RS01130 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HZR83_RS01135 ENOG4105RG0 Membrane HZR83_RS01140 ENOG4108IA2 Sodium pantothenate symporter HZR83_RS01150 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HZR83_RS01160 ENOG4105CEC DNA methylase N-4 N-6 HZR83_RS01165 ENOG41061ME transport protein HZR83_RS01170 ENOG4108XG4 DNA-binding transcriptional regulator HZR83_RS01190 ENOG4105BZS acriflavin resistance protein HZR83_RS01195 ENOG4105XCM membrane LIPOPROTEIN HZR83_RS01205 ENOG4105EZ7 amino acid ABC transporter HZR83_RS01210 ENOG4105DRP amino acid AbC transporter HZR83_RS01215 ENOG4105CDA abc transporter atp-binding protein HZR83_RS01255 ENOG4108Z0R Transferase HZR83_RS01260 ENOG4105SG3 Protein of unknown function (DUF1488) HZR83_RS01275 ENOG4108WI1 Dna topoisomerase HZR83_RS01285 ENOG4105C79 DNA protecting protein DprA HZR83_RS01305 ENOG4105C1A potassium transporter peripheral membrane HZR83_RS01315 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HZR83_RS01320 ENOG4105W1Y Transcriptional regulator HZR83_RS01325 ENOG4105VTS DnaJ-like, subfamily C HZR83_RS01355 ENOG41067V7 50S ribosomal protein L36 HZR83_RS01360 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HZR83_RS01405 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HZR83_RS01450 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HZR83_RS01470 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication HZR83_RS01475 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression HZR83_RS01480 ENOG4107KSE General secretion pathway protein C HZR83_RS01485 ENOG4105GVR general secretion pathway protein D HZR83_RS01490 ENOG4107QHF type ii secretion system protein e HZR83_RS01495 ENOG4105D7Q type ii secretion system HZR83_RS01500 ENOG4108VAU general secretion pathway protein G HZR83_RS01505 ENOG41069X0 general secretion pathway protein h HZR83_RS01520 ENOG4105R04 type II secretion system protein K HZR83_RS01525 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HZR83_RS01535 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HZR83_RS01540 ENOG4108UQY Iron-storage protein HZR83_RS01545 ENOG4105W53 bacterioferritin-associated ferredoxin HZR83_RS01585 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HZR83_RS01590 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HZR83_RS01595 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HZR83_RS01600 ENOG4105WWK YheO domain protein HZR83_RS01605 ENOG4108V1T peptidylprolyl cis-trans isomerase HZR83_RS01615 ENOG4108YZY peptidylprolyl cis-trans isomerase HZR83_RS01620 ENOG4105VKU nucleicacid-binding protein HZR83_RS01625 ENOG4105CKD glutathione-regulated potassium-efflux system protein HZR83_RS01635 ENOG4105C5H ABC transporter HZR83_RS01640 ENOG4105DNZ Alpha Beta Hydrolase HZR83_RS01650 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HZR83_RS01655 ENOG4108UKZ OsmC family HZR83_RS01665 ENOG410613R integral membrane protein, YccS YhfK family HZR83_RS01670 ENOG4105C8Y Acetylornithine aminotransferase HZR83_RS01675 ENOG4105DDQ anthranilate synthase HZR83_RS01680 ENOG4105MZU cell filamentation protein HZR83_RS01690 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HZR83_RS01700 ENOG4107QZF nitrite reductase NADPH large subunit HZR83_RS01705 ENOG4105WZK nitrite reductase NADPH small subunit HZR83_RS01710 ENOG4107V9H nitrite transporter HZR83_RS01720 ENOG4105VYH HZR83_RS01725 ENOG4107QHQ amino acid HZR83_RS01730 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HZR83_RS01735 ENOG4107Y0V Not clear, may be involved in an isomerization step HZR83_RS01740 ENOG4108KPW sugar kinase HZR83_RS01745 ENOG4105FDP GntR family transcriptional regulator HZR83_RS01750 ENOG4106PKC pyridoxal phosphate binding HZR83_RS01755 ENOG4106M0N transport system permease protein HZR83_RS01760 ENOG4105MUZ Protein of unknown function DUF2620 HZR83_RS01765 ENOG41080QX K07048 phosphotriesterase-related protein HZR83_RS01770 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HZR83_RS01775 ENOG4108626 Racemase HZR83_RS01780 ENOG4105RMW regulation of transcription, DNA-dependent HZR83_RS01785 ENOG4108M21 HZR83_RS01790 ENOG4105C31 Tryptophanyl-tRNA synthetase HZR83_RS01795 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HZR83_RS01800 ENOG4105DJV ribulose-phosphate 3-epimerase HZR83_RS01805 ENOG4105DFE Dna adenine methylase HZR83_RS01810 ENOG4105EGB membrane protein DamX HZR83_RS01815 ENOG4105D49 3-dehydroquinate synthase HZR83_RS01825 ENOG4105E4G Type IV pilus HZR83_RS01830 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HZR83_RS01835 ENOG4105XPX DNA utilization protein HofO HZR83_RS01840 ENOG41065NF Fimbrial assembly family protein HZR83_RS01845 ENOG4108U1Q Pilus assembly protein HZR83_RS01850 ENOG4108JQC penicillin-binding protein 1A HZR83_RS01855 ENOG4107RK2 ADP-ribose diphosphatase NudE HZR83_RS01860 ENOG4105DQY intracellular growth attenuator HZR83_RS01865 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HZR83_RS01870 ENOG4105VEJ Heat shock protein HZR83_RS01880 ENOG4108MAJ Membrane HZR83_RS01890 ENOG4105E0F Histidine kinase HZR83_RS01900 ENOG4108RRZ Transcription elongation factor GreB HZR83_RS01905 ENOG4105BZM domain protein HZR83_RS01910 ENOG4105XFK Ferrous iron transport protein A HZR83_RS01915 ENOG4105CE1 Ferrous iron transport protein b HZR83_RS01925 ENOG4105DNE Transposase HZR83_RS01930 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HZR83_RS01935 ENOG4105MJ2 Competence protein HZR83_RS01945 ENOG4105C6Z Gluconate HZR83_RS01950 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HZR83_RS01955 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HZR83_RS01965 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP HZR83_RS01970 ENOG4105E0Y RtcB Protein HZR83_RS01975 ENOG4105CYB regulatoR HZR83_RS01980 ENOG4105E98 transcriptional regulator DeoR family HZR83_RS01995 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HZR83_RS02005 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HZR83_RS02020 ENOG4108IUM Glycogen debranching enzyme HZR83_RS02030 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HZR83_RS02035 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HZR83_RS02040 ENOG4105C6Z Gluconate HZR83_RS02045 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HZR83_RS02050 ENOG4105DIQ Transcriptional regulator HZR83_RS02055 ENOG4105C2I pirin domain protein HZR83_RS02060 ENOG4105D9R oxidoreductase HZR83_RS02065 ENOG4105WCN acetyltransferase HZR83_RS02070 ENOG4105GMB type VI secretion system effector, hcp1 family HZR83_RS02085 ENOG4106FA4 HZR83_RS02090 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HZR83_RS02100 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HZR83_RS02105 ENOG4108IJ9 (ABC) transporter HZR83_RS02110 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HZR83_RS02115 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HZR83_RS02120 ENOG4105BZ7 extracellular solute-binding protein family 1 HZR83_RS02125 ENOG4108IV0 ABC, transporter HZR83_RS02130 ENOG4105C0Z ABC transporter HZR83_RS02135 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HZR83_RS02140 ENOG4105C32 Amino acid ABC transporter (Permease) HZR83_RS02145 ENOG4105CP9 extracellular ligand-binding receptor HZR83_RS02150 ENOG4105U59 -acetyltransferase HZR83_RS02155 ENOG4105CP9 extracellular ligand-binding receptor HZR83_RS02160 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HZR83_RS02165 ENOG4105CRP Part of the ABC transporter FtsEX involved in HZR83_RS02170 ENOG4105CAK Cell division ATP-binding protein ftsE HZR83_RS02175 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HZR83_RS02180 ENOG4106H78 methyltransferase HZR83_RS02185 ENOG4105MG3 Membrane HZR83_RS02195 ENOG4107FS9 Membrane HZR83_RS02200 ENOG4105C59 p-type ATPase HZR83_RS02210 ENOG4105EX9 Membrane HZR83_RS02215 ENOG4108W1V Lipoprotein HZR83_RS02220 ENOG4105F9N Major Facilitator Superfamily HZR83_RS02225 ENOG4105DSF transport protein HZR83_RS02230 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HZR83_RS02235 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HZR83_RS02240 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HZR83_RS02245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZR83_RS02250 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HZR83_RS02255 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HZR83_RS02265 ENOG4105CNA YD repeat protein HZR83_RS02275 ENOG4105NUP lyase containing HEAT-repeat HZR83_RS02280 ENOG410600T transposase HZR83_RS02285 ENOG4105CMI transporter HZR83_RS02290 ENOG4105CJ1 ABC, transporter HZR83_RS02295 ENOG4105D0S secretion protein (HlyD HZR83_RS02315 ENOG4107UNS conserved inner membrane protein HZR83_RS02345 ENOG4105CB5 ATP-dependent DNA helicase recG HZR83_RS02350 ENOG4105ESI atpase involved in dna repair HZR83_RS02355 ENOG4105DZR Type I site-specific deoxyribonuclease HZR83_RS02385 ENOG4105CBX hi0933 family HZR83_RS02390 ENOG4105CJ3 phosphate transporter HZR83_RS02405 ENOG4105DUX Transporter HZR83_RS02415 ENOG4105DGW oligopeptidase A HZR83_RS02420 ENOG4105D6S protein involved in catabolism of external DNA HZR83_RS02425 ENOG4105DC8 reductase HZR83_RS02435 ENOG4105KBH arsR family transcriptional regulator HZR83_RS02440 ENOG4107R5R arsenical pump membrane protein HZR83_RS02445 ENOG4105K89 arsenate reductase HZR83_RS02455 ENOG4105Y4Z Outer Membrane Lipoprotein HZR83_RS02465 ENOG4105KT7 mgtC SapB transporter HZR83_RS02470 ENOG4105XXV Acid-resistance protein HZR83_RS02475 ENOG41060V2 Acid-resistance protein HZR83_RS02480 ENOG4108YK4 Acid-resistance membrane protein HZR83_RS02485 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HZR83_RS02495 ENOG4105C1P efflux transporter, rnd family, mfp subunit HZR83_RS02500 ENOG4105BZS acriflavin resistance protein HZR83_RS02510 ENOG4108NKV transcriptional regulator HZR83_RS02515 ENOG4105CVK Glutamate decarboxylase HZR83_RS02520 ENOG4105CA0 peroxidase HZR83_RS02530 ENOG4106S2D Transcriptional regulator HZR83_RS02535 ENOG4105CBN LysR family transcriptional regulator HZR83_RS02540 ENOG4107H3J ribonuclease HZR83_RS02545 ENOG4105CSH Transporter HZR83_RS02550 ENOG41066T0 asmA family HZR83_RS02555 ENOG4105CMB EAL domain-containing protein HZR83_RS02560 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HZR83_RS02565 ENOG4105CS0 peptidase HZR83_RS02575 ENOG4105BZU Histidine kinase HZR83_RS02580 ENOG4105EJG cellulose synthase HZR83_RS02590 ENOG4107EEX Cellulose synthase regulator protein HZR83_RS02595 ENOG4107QZ7 Cellulose synthase catalytic subunit HZR83_RS02605 ENOG410661M cytoplasmic protein HZR83_RS02610 ENOG4105U74 cellulose biosynthesis protein BcsE HZR83_RS02615 ENOG4105WQA Cellulose biosynthesis protein BcsF HZR83_RS02620 ENOG4105D1V cellulose synthase operon protein YhjU HZR83_RS02630 ENOG4105C44 Serine transporter HZR83_RS02635 ENOG4108JQ7 (ABC) transporter HZR83_RS02640 ENOG4105C3U ABC transporter HZR83_RS02645 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZR83_RS02650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HZR83_RS02660 ENOG4105DEF Extracellular solute-binding protein, family 5 HZR83_RS02675 ENOG4105DIJ Phosphoethanolamine transferase HZR83_RS02680 ENOG4105FCD Major Facilitator HZR83_RS02685 ENOG4105EAX Putative lipase HZR83_RS02690 ENOG4108R3E Dna-3-methyladenine glycosylase i HZR83_RS02695 ENOG4105HNP -acetyltransferase HZR83_RS02700 ENOG4107QY8 reductase HZR83_RS02705 ENOG4108ZG0 Ompa motb domain protein HZR83_RS02710 ENOG4105C5I Dehydrogenase HZR83_RS02715 ENOG4106JH6 (LipO)protein HZR83_RS02720 ENOG4105MVF Transcriptional regulator HZR83_RS02730 ENOG41060TC Hok gef cell toxic protein HZR83_RS02750 ENOG4105RGS lipoprotein ysaB HZR83_RS02755 ENOG4105MEV Acyl-transferase HZR83_RS02760 ENOG4108Z12 YiaAB two helix domain-containing protein HZR83_RS02765 ENOG410688U Inner membrane protein yiaB HZR83_RS02770 ENOG4105CMG Carbohydrate kinase HZR83_RS02775 ENOG4105C93 Xylose Isomerase HZR83_RS02780 ENOG4105DFW ABC transporter HZR83_RS02785 ENOG4105C2J ABC transporter HZR83_RS02790 ENOG4108HWW ABC transporter HZR83_RS02795 ENOG4105T16 Transcriptional regulator (AraC family) HZR83_RS02800 ENOG4108UR8 BAX protein HZR83_RS02805 ENOG4107T9C Alpha amylase catalytic region HZR83_RS02810 ENOG4105JKW Valine--pyruvate aminotransferase HZR83_RS02815 ENOG4108XIB electron transport protein ysaA HZR83_RS02820 ENOG4105J4Q Transcriptional regulator HZR83_RS02830 ENOG4108R66 Conserved Protein HZR83_RS02835 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HZR83_RS02840 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HZR83_RS02845 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HZR83_RS02850 ENOG4105CMG Carbohydrate kinase HZR83_RS02855 ENOG4105H6Q decarboxylase HZR83_RS02860 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HZR83_RS02865 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HZR83_RS02875 ENOG4105GNX MltA-interacting MipA family protein HZR83_RS02880 ENOG4108Q2M Transcriptional regulator HZR83_RS02885 ENOG4105EFX secretion protein, HlyD family HZR83_RS02890 ENOG4105KK7 inner membrane protein YiaW HZR83_RS02900 ENOG4105C26 Dehydrogenase HZR83_RS02905 ENOG4105C0A alcohol dehydrogenase HZR83_RS02910 ENOG4105EM7 Selenocysteine-specific translation elongation factor HZR83_RS02920 ENOG4108U78 Glutathione S-transferase HZR83_RS02925 ENOG4105CNA YD repeat protein HZR83_RS02930 ENOG4105NUP lyase containing HEAT-repeat HZR83_RS02950 ENOG4105EFX secretion protein, HlyD family HZR83_RS02955 ENOG4105FP6 Protein of unknown function (DUF3302) HZR83_RS02960 ENOG4105CTS PTS system mannitol-specific HZR83_RS02970 ENOG4105E61 Mannitol repressor protein HZR83_RS02980 ENOG4108YYI Protein of unknown function (DUF2810) HZR83_RS02985 ENOG4105DAA L-lactate HZR83_RS02990 ENOG41073TP transcriptional regulator HZR83_RS03000 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HZR83_RS03005 ENOG4105D7W serine acetyltransferase HZR83_RS03020 ENOG4105VW4 glutaredoxin 3 HZR83_RS03025 ENOG4107YZP Rhodanese domain protein HZR83_RS03035 ENOG41063SB peptidase HZR83_RS03040 ENOG4105PXI polysaccharide deacetylase HZR83_RS03045 ENOG4105K64 Glycosyl transferase, family 2 HZR83_RS03055 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HZR83_RS03065 ENOG4105XA0 heptosyltransferase ii HZR83_RS03070 ENOG4105D16 lipopolysaccharide heptosyltransferase i HZR83_RS03075 ENOG4108FRV O-antigen ligase HZR83_RS03080 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HZR83_RS03085 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HZR83_RS03090 ENOG4108PDR lipopolysaccharide core biosynthesis protein HZR83_RS03095 ENOG4105X1N Glycosyl transferase family 8 HZR83_RS03100 ENOG4106AH0 Glycosyl Transferase HZR83_RS03105 ENOG4107XU6 Glycosyl transferase (Group 1 HZR83_RS03110 ENOG4105X1N Glycosyl transferase family 8 HZR83_RS03115 ENOG4107543 (lipo)polysaccharide HZR83_RS03120 ENOG4107RJ7 Glycosyl transferase (Group 1 HZR83_RS03125 ENOG4105DKP glycosyl transferase, family 9 HZR83_RS03130 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HZR83_RS03150 ENOG4105KDC 50s ribosomal protein l28 HZR83_RS03160 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HZR83_RS03165 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HZR83_RS03185 ENOG4105DSJ YicC domain protein HZR83_RS03195 ENOG4105F5P DNA-damage-inducible protein d HZR83_RS03200 ENOG4105EN6 Membrane HZR83_RS03205 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HZR83_RS03210 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HZR83_RS03220 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HZR83_RS03225 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HZR83_RS03230 ENOG4105CB5 ATP-dependent DNA helicase recG HZR83_RS03235 ENOG4105D6U Sodium Glutamate Symporter HZR83_RS03240 ENOG4105C2W permease HZR83_RS03245 ENOG4105JV1 AsmA family HZR83_RS03250 ENOG4105CJQ hydrolase, family 31 HZR83_RS03255 ENOG4105CT4 transporter HZR83_RS03265 ENOG4105S8Q sugar efflux transporter HZR83_RS03270 ENOG4108UZ3 Transporter HZR83_RS03275 ENOG4105D01 (LipO)protein HZR83_RS03280 ENOG4105T8A Uncharacterized protein YicS HZR83_RS03290 ENOG4108SAJ Protein of unknown function (DUF1198) HZR83_RS03295 ENOG4105C7N Xanthine uracil vitamin C permease HZR83_RS03300 ENOG4105CPN adenine deaminase HZR83_RS03305 ENOG4105CXY transporter HZR83_RS03310 ENOG4105CXY transporter HZR83_RS03315 ENOG4105BZU Histidine kinase HZR83_RS03320 ENOG4108KX4 response regulator HZR83_RS03325 ENOG4105M71 acetolactate synthase 1 regulatory subunit HZR83_RS03330 ENOG4105C7K acetolactate synthase HZR83_RS03350 ENOG4105E5M Multidrug resistance protein D HZR83_RS03355 ENOG4105J13 transcriptional regulator HZR83_RS03360 ENOG4105JP4 Inner membrane protein yidG HZR83_RS03365 ENOG4105VG5 Membrane HZR83_RS03370 ENOG4106DRA Inner membrane protein YidI HZR83_RS03375 ENOG4105CBG Sulfatase HZR83_RS03380 ENOG4107RUZ Sss sodium solute transporter superfamily HZR83_RS03385 ENOG4108AHD Transcriptional regulator HZR83_RS03395 ENOG4105CI1 PTS System HZR83_RS03400 ENOG4105FDP GntR family transcriptional regulator HZR83_RS03420 ENOG4105R2A (LipO)protein HZR83_RS03425 ENOG4105D99 atp gtp-binding protein HZR83_RS03430 ENOG4107WAP fad NAD(P)-binding domain HZR83_RS03435 ENOG4105DJB Major Facilitator Superfamily HZR83_RS03445 ENOG4108RTU Aldolase HZR83_RS03450 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HZR83_RS03455 ENOG4105EMF GntR family transcriptional regulator HZR83_RS03460 ENOG410657R replicase EC 2.7 HZR83_RS03465 ENOG410667J hydrolase HZR83_RS03470 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HZR83_RS03475 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HZR83_RS03485 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HZR83_RS03500 ENOG4105VG0 50S ribosomal protein l34 HZR83_RS03515 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HZR83_RS03520 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HZR83_RS03535 ENOG4108P6C Tryptophan transporter of low affinity HZR83_RS03540 ENOG4105CNH Multidrug resistance protein MdtL HZR83_RS03545 ENOG4105G2Y Transcriptional regulator HZR83_RS03550 ENOG4105E8Q phosphopantetheinyl transferase HZR83_RS03555 ENOG4108YYH Nadph-dependent fmn reductase HZR83_RS03560 ENOG4105C7N Xanthine uracil vitamin C permease HZR83_RS03565 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HZR83_RS03570 ENOG4106HGK Inner membrane protein yieI HZR83_RS03580 ENOG4105E5H Transposase HZR83_RS03585 ENOG4108YXQ IS66 Orf2 family protein HZR83_RS03600 ENOG4107VKM 6-phosphogluconolactonase HZR83_RS03605 ENOG4105DYC esterase HZR83_RS03615 ENOG4105CS2 ec 3.2.1.21 HZR83_RS03620 ENOG4105C5Y PTS System HZR83_RS03625 ENOG4105CID antiterminator HZR83_RS03630 ENOG4108UTW Plays a role in the regulation of phosphate uptake HZR83_RS03635 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HZR83_RS03640 ENOG4105E2Z phosphate ABC transporter (Permease HZR83_RS03645 ENOG4105C8U phosphate abc transporter HZR83_RS03650 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HZR83_RS03655 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HZR83_RS03705 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HZR83_RS03720 ENOG4105QTB Flavodoxin HZR83_RS03725 ENOG4108VVK transcriptional Regulator, AsnC HZR83_RS03735 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HZR83_RS03750 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HZR83_RS03755 ENOG4105C2J ABC transporter HZR83_RS03760 ENOG4105CNN ABC, transporter HZR83_RS03765 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HZR83_RS03770 ENOG4108RVA ribokinase HZR83_RS03775 ENOG4105ETE Transcriptional regulator (LacI family HZR83_RS03780 ENOG4105C0R drug resistance transporter emrb qaca subfamily HZR83_RS03785 ENOG4107EJG GntR family transcriptional regulator HZR83_RS03825 ENOG4108WFC UPF0438 protein yifE HZR83_RS03830 ENOG4105C0P Mg chelatase subunit ChlI HZR83_RS03850 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HZR83_RS03855 ENOG4105CM2 brancheD-chain amino acid aminotransferase HZR83_RS03865 ENOG4105C7B Threonine dehydratase HZR83_RS03870 ENOG4105EMY transcriptional regulator HZR83_RS03880 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HZR83_RS03890 ENOG4105C4R Atp-dependent dna helicase HZR83_RS03915 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HZR83_RS03920 ENOG4105ESV Glycosyl transferase, family 4 HZR83_RS03925 ENOG4105SFE lipopolysaccharide biosynthesis protein HZR83_RS03930 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HZR83_RS03935 ENOG4107QQG Dehydrogenase HZR83_RS03940 ENOG4105C1B dTDP-glucose 4-6-dehydratase HZR83_RS03945 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HZR83_RS03950 ENOG4108WJ1 acetyltransferase HZR83_RS03955 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HZR83_RS03960 ENOG4105EGZ biosynthesis protein HZR83_RS03965 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HZR83_RS03970 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HZR83_RS03975 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HZR83_RS03980 ENOG4105C85 amino acid HZR83_RS04005 ENOG4105C4X radical SAM domain protein HZR83_RS04010 ENOG4105ENH Sulfatase HZR83_RS04015 ENOG410601J HemY protein HZR83_RS04020 ENOG4105ECF c-methyltransferase HZR83_RS04025 ENOG41076E6 Uroporphyrinogen-III Synthase HZR83_RS04030 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HZR83_RS04035 ENOG4107T0K Adenylate cyclase HZR83_RS04045 ENOG4105S7Z (LipO)protein HZR83_RS04055 ENOG4105CT0 Protein of unknown function, DUF484 HZR83_RS04065 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HZR83_RS04070 ENOG4105C4R Atp-dependent dna helicase HZR83_RS04075 ENOG4108T58 Mg2 transport protein CorA HZR83_RS04080 ENOG4107QUT magnesium and cobalt transport protein CorA HZR83_RS04085 ENOG4105NRM Membrane HZR83_RS04090 ENOG4106WR8 Inner membrane protein YigG HZR83_RS04095 ENOG4105FR1 rard protein HZR83_RS04100 ENOG4108VUY thioesterase Superfamily protein HZR83_RS04105 ENOG4105HDD phospholipase HZR83_RS04110 ENOG4105C9U ATP-dependent DNA helicase RecQ HZR83_RS04115 ENOG4105CCF Lysine exporter protein (Lyse ygga) HZR83_RS04120 ENOG410829K Lysine exporter protein (Lyse ygga) HZR83_RS04125 ENOG4108EUD Lysophospholipase HZR83_RS04130 ENOG4105DQF Hydrolase HZR83_RS04135 ENOG4105EMK carboxylate amino acid amine transporter HZR83_RS04140 ENOG4105DZ2 Transcriptional regulator HZR83_RS04145 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HZR83_RS04150 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HZR83_RS04155 ENOG4108I5U Uridine phosphorylase HZR83_RS04160 ENOG4105CGY Dna recombination protein HZR83_RS04170 ENOG4105JC1 sterol-binding domain protein HZR83_RS04180 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HZR83_RS04185 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HZR83_RS04190 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HZR83_RS04195 ENOG4105F8V Hydrolase, tatD family HZR83_RS04200 ENOG4105MDZ Transcriptional activator rfaH HZR83_RS04205 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HZR83_RS04210 ENOG4108EX3 reductase HZR83_RS04215 ENOG4105CHU acetyl-coa acetyltransferase HZR83_RS04220 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HZR83_RS04230 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HZR83_RS04235 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HZR83_RS04240 ENOG4108RR8 protoporphyrinogen oxidase HZR83_RS04270 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HZR83_RS04275 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HZR83_RS04280 ENOG4105PC1 Conserved Protein HZR83_RS04285 ENOG4105E27 serine threonine protein kinase HZR83_RS04290 ENOG4108Z33 Thiol disulfide Interchange Protein HZR83_RS04300 ENOG4106HNH Acyl-transferase HZR83_RS04305 ENOG4105C2M dna polymerase I HZR83_RS04320 ENOG4105D4P Coproporphyrinogen iii oxidase HZR83_RS04325 ENOG4106FIY HZR83_RS04330 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HZR83_RS04335 ENOG4105CUX Signal transduction histidine kinase HZR83_RS04340 ENOG4105C5F glutamine synthetase HZR83_RS04345 ENOG4105CI3 gtp-binding protein typa HZR83_RS04350 ENOG4108K85 Transcriptional regulator HZR83_RS04355 ENOG4108KHF Resistance protein HZR83_RS04360 ENOG4105R9B Major Facilitator HZR83_RS04365 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HZR83_RS04370 ENOG4105CT4 transporter HZR83_RS04375 ENOG4105CT4 transporter HZR83_RS04380 ENOG4105CJQ hydrolase, family 31 HZR83_RS04385 ENOG4107WI4 Aldose-1-epimerase HZR83_RS04390 ENOG4107QKS N-acylglucosamine 2-epimerase HZR83_RS04395 ENOG4105D2M Aldolase HZR83_RS04400 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HZR83_RS04405 ENOG4108MGF sugar kinase HZR83_RS04410 ENOG4105E98 transcriptional regulator DeoR family HZR83_RS04415 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HZR83_RS04430 ENOG4105SUU thioesterase domain HZR83_RS04440 ENOG41068KX affects formate dehydrogenase-N HZR83_RS04445 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HZR83_RS04450 ENOG4108MG3 formate dehydrogenase HZR83_RS04455 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HZR83_RS04465 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HZR83_RS04470 ENOG4108V87 frv operon regulatory protein HZR83_RS04475 ENOG4106C3V frv operon regulatory protein HZR83_RS04480 ENOG4105CN9 Peptidase m42 family protein HZR83_RS04485 ENOG4105DM4 PTS System HZR83_RS04490 ENOG41064BA PTS system, fructose-specific, IIA component HZR83_RS04505 ENOG4105DKG l-rhamnose isomerase HZR83_RS04510 ENOG4105DET Rhamnulokinase HZR83_RS04525 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HZR83_RS04530 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HZR83_RS04540 ENOG4108RPX mosc domain containing protein HZR83_RS04545 ENOG4105E0F Histidine kinase HZR83_RS04550 ENOG4105E3W Two component transcriptional regulator (Winged helix family HZR83_RS04555 ENOG4105FMW periplasmic HZR83_RS04560 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HZR83_RS04605 ENOG4105VZ1 Replication Protein HZR83_RS04625 ENOG4105ED4 portal protein HZR83_RS04720 ENOG4105UZW Tail fiber assembly protein HZR83_RS04730 ENOG4108C33 Resolvase HZR83_RS04770 ENOG4105ZTC transcriptional activator, Ogr delta HZR83_RS04785 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HZR83_RS04790 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HZR83_RS04800 ENOG4105EBK exported protein HZR83_RS04805 ENOG4108VTS Membrane HZR83_RS04810 ENOG41065TG regulatoR HZR83_RS04820 ENOG4105DP0 ferredoxin-NADP reductase HZR83_RS04825 ENOG4105CBT Fructose-1,6-bisphosphatase HZR83_RS04835 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HZR83_RS04850 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HZR83_RS04865 ENOG41063M6 Cell Division Protein HZR83_RS04870 ENOG4105ETE Transcriptional regulator (LacI family HZR83_RS04875 ENOG4105C25 Primosomal protein n' HZR83_RS04885 ENOG4107S01 Repressor protein MetJ HZR83_RS04895 ENOG4105C28 cystathionine HZR83_RS04900 ENOG4105CFH Aspartokinase HZR83_RS04905 ENOG4105SYT Methylenetetrahydrofolate reductase HZR83_RS04915 ENOG4108Q5Y Membrane HZR83_RS04920 ENOG4108XC3 NADH ubiquinone oxidoreductase HZR83_RS04925 ENOG4105DCT glycerol dehydrogenase HZR83_RS04930 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HZR83_RS04935 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HZR83_RS04940 ENOG4105DM4 PTS System HZR83_RS04945 ENOG4108YRF PTS System HZR83_RS04955 ENOG4108AHH pyruvate formate lyase II activase HZR83_RS04960 ENOG4108XCZ PTS System HZR83_RS04965 ENOG4106R3P AraC family transcriptional regulator HZR83_RS04970 ENOG4105DIJ Phosphoethanolamine transferase HZR83_RS04975 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HZR83_RS04980 ENOG4105CWC Acetylornithine deacetylase HZR83_RS04985 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HZR83_RS05000 ENOG4105C5Q Transcriptional regulator HZR83_RS05010 ENOG4105EJ2 Transcriptional regulator HZR83_RS05015 ENOG4108Y73 Membrane HZR83_RS05025 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HZR83_RS05030 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HZR83_RS05055 ENOG4105D4A Cell wall formation (By similarity) HZR83_RS05060 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HZR83_RS05095 ENOG4105PM1 preprotein translocase subunit SecE HZR83_RS05100 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HZR83_RS05135 ENOG410645W Thiamin biosynthesis protein ThiH HZR83_RS05140 ENOG4105D41 biosynthesis protein thiH HZR83_RS05145 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HZR83_RS05150 ENOG4105WHD thiamine biosynthesis protein ThiS HZR83_RS05155 ENOG4105D06 uba thif-type nad fad binding protein HZR83_RS05190 ENOG4105R2J Conserved Protein HZR83_RS05200 ENOG4108T8B Protein of unknown function (DUF1481) HZR83_RS05205 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HZR83_RS05210 ENOG4105BZU Histidine kinase HZR83_RS05215 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HZR83_RS05220 ENOG4105C12 Phosphoribosylglycinamide synthetase HZR83_RS05225 ENOG4105DC1 bifunctional purine biosynthesis protein purh HZR83_RS05250 ENOG41062WK cellular response to acidity HZR83_RS05255 ENOG4105K5X acetyltransferase HZR83_RS05260 ENOG4105CVG Homoserine O-transsuccinylase HZR83_RS05265 ENOG4107QP3 malate synthase g HZR83_RS05270 ENOG4108I9X Isocitrate lyase HZR83_RS05275 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HZR83_RS05285 ENOG41069M3 Transcriptional regulator HZR83_RS05290 ENOG4105C3R Methionine synthase HZR83_RS05295 ENOG4105EAM Na Pi-cotransporter HZR83_RS05305 ENOG4105FE9 pseudouridine synthase HZR83_RS05310 ENOG4108ZR5 Conserved Protein HZR83_RS05315 ENOG4105CFH Aspartokinase HZR83_RS05320 ENOG4107QP8 phosphohexose isomerase HZR83_RS05330 ENOG4108MDC (LipO)protein HZR83_RS05335 ENOG4108Q9C Periplasmic Protein HZR83_RS05340 ENOG4105E3R (LipO)protein HZR83_RS05375 ENOG4105EG2 ABC transporter, permease HZR83_RS05380 ENOG4105D56 permease protein HZR83_RS05385 ENOG4107FKK extracellular solute-binding protein family 1 HZR83_RS05390 ENOG4108IJ9 (ABC) transporter HZR83_RS05395 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HZR83_RS05400 ENOG4107W52 maltose operon periplasmic protein HZR83_RS05410 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HZR83_RS05425 ENOG41080IJ Diacylglycerol kinase HZR83_RS05435 ENOG4107R73 Mate efflux family protein HZR83_RS05440 ENOG4105VDW Csbd family HZR83_RS05445 ENOG4105MYN Zinc uptake regulation protein HZR83_RS05455 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HZR83_RS05460 ENOG4105P4Z Phage shock protein G HZR83_RS05465 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HZR83_RS05470 ENOG4105CDU Replicative dna helicase HZR83_RS05475 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HZR83_RS05480 ENOG4105CGF Aromatic amino acid aminotransferase HZR83_RS05490 ENOG4105F0S class B acid phosphatase HZR83_RS05495 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HZR83_RS05500 ENOG4105MSB protein, conserved in bacteria HZR83_RS05505 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HZR83_RS05510 ENOG4108UUM single-stranded DNA-binding protein HZR83_RS05515 ENOG4105PMV Membrane HZR83_RS05520 ENOG4108M8H domain protein HZR83_RS05525 ENOG4108W3Q Transcriptional regulator HZR83_RS05530 ENOG4108Z4X TRANSCRIPTIONal HZR83_RS05535 ENOG4105C7N Xanthine uracil vitamin C permease HZR83_RS05540 ENOG4105EEQ Na H antiporter HZR83_RS05555 ENOG41062QD Membrane HZR83_RS05560 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HZR83_RS05570 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HZR83_RS05575 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HZR83_RS05580 ENOG4105DVI reductase, NrfD HZR83_RS05585 ENOG4108QKW cytochrome c-type biogenesis protein HZR83_RS05595 ENOG4108W0S formate-dependent nitrite reductase complex HZR83_RS05600 ENOG4105CK2 sodium dicarboxylate symporter HZR83_RS05605 ENOG41082ND Uncharacterized protein yjcO HZR83_RS05615 ENOG4105ETP RND efflux system, outer membrane lipoprotein HZR83_RS05620 ENOG4108MI0 Resistance protein HZR83_RS05625 ENOG4105J12 Multidrug resistance protein mdtN HZR83_RS05630 ENOG4106833 HZR83_RS05635 ENOG4105EUZ Beta-lactamase domain protein HZR83_RS05640 ENOG4107TFG D-allose kinase HZR83_RS05645 ENOG4105UP7 3-epimerase HZR83_RS05650 ENOG4105CNN ABC, transporter HZR83_RS05655 ENOG4105C2J ABC transporter HZR83_RS05660 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HZR83_RS05665 ENOG4105NYY transcriptional regulator, RpiR HZR83_RS05670 ENOG4108YZG isomerase HZR83_RS05680 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HZR83_RS05685 ENOG410849A acetyltransferase, (GNAT) family HZR83_RS05690 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HZR83_RS05695 ENOG4105FD8 phosphonate metabolism protein PhnM HZR83_RS05700 ENOG4105HRV phosphonate c-p lyase system protein phnl HZR83_RS05705 ENOG4105ENV phosphonate C-P lyase system protein PhnK HZR83_RS05710 ENOG4105FT8 Phosphonate metabolism HZR83_RS05715 ENOG4105EKV Phosphonate metabolism protein HZR83_RS05720 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HZR83_RS05725 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HZR83_RS05730 ENOG4107RJJ Transcriptional regulator HZR83_RS05740 ENOG4105EHI Phosphonate ABC transporter, periplasmic HZR83_RS05745 ENOG4105D5T phosphonate abc transporter HZR83_RS05750 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HZR83_RS05755 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HZR83_RS05765 ENOG4108YIV HZR83_RS05770 ENOG4105CSH Transporter HZR83_RS05780 ENOG4105ECM Sensor protein basS pmrB HZR83_RS05785 ENOG4105XJC Two component transcriptional regulator (Winged helix family HZR83_RS05790 ENOG4105DIJ Phosphoethanolamine transferase HZR83_RS05795 ENOG4105D5Q Arginine ornithine antiporter HZR83_RS05800 ENOG4106ZGR Transcriptional regulator HZR83_RS05805 ENOG4105CXN decarboxylase HZR83_RS05810 ENOG4108K2B transcriptional regulator HZR83_RS05815 ENOG4105F8D glycoside hydrolase family 4 HZR83_RS05820 ENOG4105CT4 transporter HZR83_RS05825 ENOG4108R5S membrane HZR83_RS05830 ENOG4107GFK fumarate HZR83_RS05835 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HZR83_RS05840 ENOG4108MRH transcriptional regulatory protein HZR83_RS05845 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HZR83_RS05850 ENOG4105VR1 Pfam:DUF1271 HZR83_RS05855 ENOG410830R acetyltransferase HZR83_RS05870 ENOG4105CRK lysyL-tRNA synthetase HZR83_RS05875 ENOG4105DUX Transporter HZR83_RS05880 ENOG4105CXN decarboxylase HZR83_RS05885 ENOG4105D5Q Arginine ornithine antiporter HZR83_RS05890 ENOG4108M3R transcriptional activator CadC HZR83_RS05900 ENOG4108SIC Transcriptional regulator HZR83_RS05905 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HZR83_RS05915 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HZR83_RS05920 ENOG4108IJ0 Aspartate ammonia-lyase HZR83_RS05925 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HZR83_RS05930 ENOG4105DVH amino acid HZR83_RS05945 ENOG4108ZVF (LipO)protein HZR83_RS05965 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HZR83_RS05975 ENOG4107PEH Entericidin EcnA/B family HZR83_RS05980 ENOG4106BSU Entericidin B HZR83_RS05985 ENOG4105KPY Small multidrug resistance protein HZR83_RS05990 ENOG4105QNF Outer membrane lipoprotein HZR83_RS05995 ENOG41066YJ Beta-lactamase HZR83_RS06010 ENOG4105E33 succinate dehydrogenase HZR83_RS06015 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HZR83_RS06020 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HZR83_RS06025 ENOG4107SC7 Inner membrane transporter yjeM HZR83_RS06030 ENOG4106V5W HZR83_RS06035 ENOG4106CG8 Inner membrane protein YjeO HZR83_RS06040 ENOG4105EGS Mechanosensitive ion channel HZR83_RS06080 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HZR83_RS06085 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HZR83_RS06090 ENOG4105K8N protein family UPF0079, ATPase HZR83_RS06095 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HZR83_RS06100 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HZR83_RS06115 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HZR83_RS06120 ENOG4107QJR hflk protein HZR83_RS06125 ENOG4105EPW hflc protein HZR83_RS06145 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HZR83_RS06150 ENOG4105C2N RNA methyltransferase TrmH family group 3 HZR83_RS06155 ENOG4107HP6 Transcriptional regulator HZR83_RS06160 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HZR83_RS06165 ENOG4105CSP Major Facilitator Superfamily HZR83_RS06170 ENOG4105CTX dehydratase HZR83_RS06185 ENOG4107VNS Protein of unknown function (DUF2491) HZR83_RS06195 ENOG4105Z6B inner membrane protein yjfl HZR83_RS06200 ENOG4108KXT Conserved Protein HZR83_RS06205 ENOG4106032 Glutathionylspermidine synthase HZR83_RS06210 ENOG4105CSU acyl-Coa dehydrogenase HZR83_RS06215 ENOG4105S17 UPF0379 protein yjfN HZR83_RS06220 ENOG4105WSB biofilm stress and motility protein A HZR83_RS06225 ENOG4108MXZ Esterase HZR83_RS06245 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HZR83_RS06250 ENOG4106ETB IIa component HZR83_RS06265 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HZR83_RS06270 ENOG4105R3P Inner membrane protein yagU HZR83_RS06275 ENOG4105KIT UPF0379 protein yjfY HZR83_RS06290 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HZR83_RS06305 ENOG4108RS6 transposase HZR83_RS06310 ENOG4105D7V transposase HZR83_RS06320 ENOG4105FHY Opacity-associated protein A HZR83_RS06325 ENOG4108V1T peptidylprolyl cis-trans isomerase HZR83_RS06330 ENOG4105C85 amino acid HZR83_RS06340 ENOG4105DXC membrane HZR83_RS06345 ENOG4105ECR NmrA family HZR83_RS06350 ENOG4105KVH Transcriptional regulator HZR83_RS06355 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HZR83_RS06360 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HZR83_RS06370 ENOG4108UUE Transcriptional regulator HZR83_RS06375 ENOG41061GZ Protein of unknown function (DUF1107) HZR83_RS06380 ENOG4105C37 (CBS) domain HZR83_RS06390 ENOG4105CFU surface antigen HZR83_RS06395 ENOG4105MA0 exported protein HZR83_RS06400 ENOG4108ZHD aig2 family HZR83_RS06405 ENOG41087RY SpoVT_AbrB HZR83_RS06410 ENOG4105MZG transcriptional modulator of maze toxin, mazf HZR83_RS06415 ENOG4105F0N pyrophosphate phospho-hydrolase HZR83_RS06420 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HZR83_RS06425 ENOG4105C2J ABC transporter HZR83_RS06430 ENOG4107R9N ABC transporter HZR83_RS06435 ENOG41062B0 ABC transporter, permease HZR83_RS06445 ENOG4105DFU Cell wall formation (By similarity) HZR83_RS06455 ENOG4105CMS peptidase U62, modulator of DNA gyrase HZR83_RS06465 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HZR83_RS06470 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HZR83_RS06475 ENOG4105CG3 alpha amylase, catalytic region HZR83_RS06480 ENOG4105C5Y PTS System HZR83_RS06485 ENOG4105D4X repressor HZR83_RS06495 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HZR83_RS06500 ENOG4105KME endoribonuclease L-psp HZR83_RS06515 ENOG4107C93 pyrBI operon leader peptide HZR83_RS06520 ENOG4108UQ8 endoribonuclease L-psp HZR83_RS06525 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HZR83_RS06530 ENOG4108XFH Transcriptional regulator HZR83_RS06535 ENOG4105XEP YhcH YjgK YiaL family protein HZR83_RS06550 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HZR83_RS06555 ENOG4108MJ3 acetyltransferase HZR83_RS06580 ENOG4105MYG DNA polymerase iii, chi subunit HZR83_RS06590 ENOG4108M8S permease YjgP YjgQ family protein HZR83_RS06595 ENOG4108K5H permease YjgP YjgQ family protein HZR83_RS06600 ENOG4105D7A ATP-binding protein HZR83_RS06605 ENOG4105DQ4 alcohol dehydrogenase HZR83_RS06680 ENOG4107RRE RNA-directed DNA polymerase HZR83_RS06700 ENOG4108WUH Transcriptional regulator, TetR family HZR83_RS06715 ENOG4105C94 Transporter HZR83_RS06740 ENOG4107BJW polysaccharide deacetylase HZR83_RS06750 ENOG4105EKQ RNA-directed DNA polymerase HZR83_RS06765 ENOG4105E0A ABC, transporter HZR83_RS06770 ENOG4108IHU transport system permease protein HZR83_RS06775 ENOG4105DQ5 transport system permease protein HZR83_RS06780 ENOG4108HUF Transporter HZR83_RS06785 ENOG4105GAV receptor HZR83_RS06790 ENOG4108S3W Anti-feci sigma factor, fecr HZR83_RS06795 ENOG4108SF5 RNA Polymerase HZR83_RS06830 ENOG4105E5H Transposase HZR83_RS06835 ENOG4108YXQ IS66 Orf2 family protein HZR83_RS06870 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HZR83_RS06885 ENOG4107EFN gluconate transport system permease 3 HZR83_RS06895 ENOG4105DEI Mannitol dehydrogenase HZR83_RS06900 ENOG4105C6F GntR Family Transcriptional Regulator HZR83_RS06920 ENOG4107YNJ LysR family Transcriptional regulator HZR83_RS06925 ENOG4105DYB Isoaspartyl dipeptidase HZR83_RS06930 ENOG4108P2H Inner membrane protein YjiG HZR83_RS06935 ENOG41074DU domain protein HZR83_RS06945 ENOG4105CBP Major Facilitator HZR83_RS06960 ENOG4105CIZ coA-substrate-specific enzyme activase HZR83_RS06965 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HZR83_RS06970 ENOG4106BRA Membrane HZR83_RS06975 ENOG41083G8 Multidrug resistance protein MdtM HZR83_RS06995 ENOG4105CKI cobalamin synthesis protein HZR83_RS07000 ENOG4105VCD cytoplasmic protein HZR83_RS07005 ENOG4105D22 carbon starvation protein HZR83_RS07010 ENOG4105C8Q Methyl-accepting chemotaxis HZR83_RS07015 ENOG4108I5G Major Facilitator superfamily HZR83_RS07020 ENOG410617M Transcriptional regulator HZR83_RS07025 ENOG4105CPQ Dehydrogenase HZR83_RS07035 ENOG4105RI1 glycoprotein receptor HZR83_RS07040 ENOG4106CVF DNA replication protein HZR83_RS07055 ENOG4105DWK Membrane HZR83_RS07060 ENOG4108N8T regulatoR HZR83_RS07065 ENOG4108T94 DNA-binding transcriptional activator BglJ HZR83_RS07070 ENOG4108819 ferric iron reductase HZR83_RS07075 ENOG4105YBH Protein of unknown function (DUF1435) HZR83_RS07095 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HZR83_RS07100 ENOG4108WPU DNA polymerase III subunit psi HZR83_RS07105 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HZR83_RS07110 ENOG4105PAD Hydrolase HZR83_RS07120 ENOG4105K3G Periplasmic Protein HZR83_RS07130 ENOG4108NRW Phospholipase, patatin family HZR83_RS07135 ENOG4105EYA deoxyribonuclease HZR83_RS07140 ENOG41076CZ activating enzyme HZR83_RS07145 ENOG4105G0K glycine radical enzyme YjjI family HZR83_RS07180 ENOG41062Z9 Membrane HZR83_RS07185 ENOG4105EAC phosphoserine phosphatase HZR83_RS07190 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HZR83_RS07195 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HZR83_RS07205 ENOG4105C5H ABC transporter HZR83_RS07210 ENOG4107SC1 transglycosylase HZR83_RS07230 ENOG4105UEI Transcriptional Regulator AraC Family HZR83_RS07235 ENOG4108RH0 Crea protein HZR83_RS07240 ENOG4105E3W Two component transcriptional regulator (Winged helix family HZR83_RS07245 ENOG4105EB3 Histidine kinase HZR83_RS07250 ENOG4105CT7 inner membrane cred family protein HZR83_RS07255 ENOG41065U4 response regulator HZR83_RS07260 ENOG410759A HZR83_RS07265 ENOG4106FVC RNA methyltransferase HZR83_RS07275 ENOG4105CFH Aspartokinase HZR83_RS07285 ENOG4105D98 threonine synthase HZR83_RS07290 ENOG41062C6 Protein of unknown function (DUF2502) HZR83_RS07300 ENOG4105BZG amino acid carrier protein HZR83_RS07305 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HZR83_RS07310 ENOG4108RIR Molybdenum cofactor biosynthesis protein HZR83_RS07315 ENOG4106HK8 GPR1 FUN34 yaaH family protein HZR83_RS07320 ENOG4108QUJ UPF0174 protein YaaW HZR83_RS07340 ENOG4108SER Transposase HZR83_RS07345 ENOG4105WI6 cell killing protein encoded within cryptic prophage HZR83_RS07360 ENOG41063Z6 transcriptional regulator, lysR family HZR83_RS07385 ENOG410647N response to DNA damage stimulus HZR83_RS07390 ENOG4105DTN riboflavin biosynthesis protein ribF HZR83_RS07395 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HZR83_RS07405 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HZR83_RS07420 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HZR83_RS07425 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HZR83_RS07430 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HZR83_RS07435 ENOG4108XNW Transcriptional activatory protein CaiF HZR83_RS07445 ENOG4106YT9 Enoyl-CoA hydratase HZR83_RS07475 ENOG4105C10 Electron transfer flavoprotein HZR83_RS07480 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HZR83_RS07485 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HZR83_RS07490 ENOG4105C54 Major Facilitator superfamily HZR83_RS07500 ENOG4105CKD glutathione-regulated potassium-efflux system protein HZR83_RS07505 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HZR83_RS07510 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HZR83_RS07525 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HZR83_RS07530 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HZR83_RS07535 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HZR83_RS07540 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HZR83_RS07560 ENOG4105D3G Pseudouridine synthase HZR83_RS07565 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HZR83_RS07570 ENOG4105CQ2 DNA polymerase HZR83_RS07575 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HZR83_RS07580 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HZR83_RS07585 ENOG4105EF1 ribulokinase HZR83_RS07590 ENOG41063TF transcriptional regulator (AraC HZR83_RS07595 ENOG4108KF1 Membrane HZR83_RS07600 ENOG4107T0D ABC, transporter HZR83_RS07605 ENOG4106SMU thiamine transporter membrane protein HZR83_RS07610 ENOG4105DP9 ABC transporter HZR83_RS07615 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HZR83_RS07625 ENOG4105S8Q sugar efflux transporter HZR83_RS07640 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HZR83_RS07655 ENOG41064T2 transcriptional regulator, lysR family HZR83_RS07665 ENOG4105C7K acetolactate synthase HZR83_RS07670 ENOG4108ZP8 Acetolactate synthase small subunit HZR83_RS07680 ENOG4107B7Y DNA-binding transcriptional regulator FruR HZR83_RS07695 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HZR83_RS07700 ENOG4105CJN penicillin-binding protein HZR83_RS07705 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HZR83_RS07710 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HZR83_RS07725 ENOG4105CNI cell division protein FtsW HZR83_RS07740 ENOG4105CPF Cell wall formation (By similarity) HZR83_RS07745 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HZR83_RS07750 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HZR83_RS07755 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HZR83_RS07765 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HZR83_RS07775 ENOG4105M6F mutator MutT protein HZR83_RS07790 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HZR83_RS07805 ENOG4105D7Q type ii secretion system HZR83_RS07810 ENOG4107QHF type ii secretion system protein e HZR83_RS07815 ENOG4108ZUW Major pilin subunit HZR83_RS07820 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HZR83_RS07825 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HZR83_RS07830 ENOG4106A72 regulatory protein AmpE HZR83_RS07835 ENOG4105C85 amino acid HZR83_RS07840 ENOG41073TP transcriptional regulator HZR83_RS07845 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HZR83_RS07850 ENOG4107QSN dihydrolipoamide acetyltransferase HZR83_RS07855 ENOG4107QN2 dihydrolipoyl dehydrogenase HZR83_RS07860 ENOG4108NST exported protein HZR83_RS07865 ENOG4107QIJ Aconitate hydratase 2 HZR83_RS07885 ENOG4108ZRK uncharacterized protein yacC HZR83_RS07890 ENOG4105E3B Multicopper oxidase HZR83_RS07895 ENOG4105DZG Dehydrogenase HZR83_RS07900 ENOG4108UGV hypoxanthine phosphoribosyltransferase HZR83_RS07905 ENOG41077A9 carbonic anhydrase HZR83_RS07910 ENOG4105DA5 (ABC) transporter HZR83_RS07915 ENOG4105E3A (ABC) transporter HZR83_RS07920 ENOG4108YTN IIa component HZR83_RS07925 ENOG4107BJW polysaccharide deacetylase HZR83_RS07935 ENOG4108A32 Transposase HZR83_RS07945 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HZR83_RS07950 ENOG4105P0Q fimbrial-like protein YadC HZR83_RS07955 ENOG4105SN2 fimbrial-like adhesin protein HZR83_RS07960 ENOG4105SYG Fimbrial protein HZR83_RS07965 ENOG4108XEY fimbrial-like adhesin protein HZR83_RS07970 ENOG4105CW0 outer membrane usher protein HZR83_RS07975 ENOG4108VEV chaperone HZR83_RS07985 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HZR83_RS07990 ENOG4105DJ0 Poly(A) Polymerase HZR83_RS08010 ENOG4107XID 2'-5' rna ligase HZR83_RS08015 ENOG4105CQ7 ATP-dependent helicase HZR83_RS08020 ENOG4105BZ4 penicillin-binding protein HZR83_RS08025 ENOG4105E0K tonB-dependent siderophore receptor HZR83_RS08030 ENOG4105E0A ABC, transporter HZR83_RS08035 ENOG4105J76 Periplasmic binding protein HZR83_RS08040 ENOG4105S6R Iron-hydroxamate transporter permease subunit HZR83_RS08065 ENOG4105EN6 Membrane HZR83_RS08070 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HZR83_RS08085 ENOG4105C0H protease HZR83_RS08090 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HZR83_RS08100 ENOG4105DIN metallophosphoesterase HZR83_RS08110 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HZR83_RS08115 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HZR83_RS08140 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HZR83_RS08145 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HZR83_RS08150 ENOG4105KNE Phosphatidate cytidylyltransferase HZR83_RS08155 ENOG4105DZP Membrane-associated zinc metalloprotease HZR83_RS08165 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HZR83_RS08170 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HZR83_RS08195 ENOG4105C0B DNA polymerase III (alpha subunit) HZR83_RS08205 ENOG4105CXN decarboxylase HZR83_RS08210 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HZR83_RS08215 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HZR83_RS08220 ENOG4105M1T rho-binding antiterminator HZR83_RS08230 ENOG4108VWS Yaeq family HZR83_RS08235 ENOG4108YZN class I peptide chain release factor HZR83_RS08240 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HZR83_RS08245 ENOG4108UY0 (LipO)protein HZR83_RS08255 ENOG4108R96 Methyltransferase, YaeB family HZR83_RS08260 ENOG4108R8X outer membrane lipoprotein HZR83_RS08265 ENOG4105D01 (LipO)protein HZR83_RS08270 ENOG4108UMI ABC transporter, permease HZR83_RS08275 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HZR83_RS08280 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HZR83_RS08315 ENOG4105CV8 reductase HZR83_RS08320 ENOG4105HEI LysR family (Transcriptional regulator HZR83_RS08335 ENOG4105E9H Lytic Murein transglycosylase HZR83_RS08340 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HZR83_RS08345 ENOG4105D1A Methyltransferase HZR83_RS08355 ENOG4107RZZ dna polymerase iii epsilon subunit HZR83_RS08365 ENOG410600K aminopeptidase HZR83_RS08380 ENOG4105GMB type VI secretion system effector, hcp1 family HZR83_RS08405 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HZR83_RS08460 ENOG4108WC9 type VI secretion system effector, hcp1 family HZR83_RS08470 ENOG4105CS6 Rhs element vgr protein HZR83_RS08475 ENOG4105CNA YD repeat protein HZR83_RS08485 ENOG410600T transposase HZR83_RS08490 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HZR83_RS08495 ENOG4108WN0 inhibitor of vertebrate lysozyme HZR83_RS08500 ENOG4107QPN acyl-Coa dehydrogenase HZR83_RS08510 ENOG4105E7A Glutamine amidotransferase HZR83_RS08515 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HZR83_RS08520 ENOG4105VXN addiction module toxin, RelE StbE family HZR83_RS08525 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression HZR83_RS08530 ENOG4108YS0 lipoprotein YafL HZR83_RS08535 ENOG4108UK5 Transposase HZR83_RS08550 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HZR83_RS08555 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system HZR83_RS08560 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome HZR83_RS08565 ENOG4108HYG acetyltransferase HZR83_RS08580 ENOG4105CIN aminoacyl-histidine dipeptidase HZR83_RS08590 ENOG4105V1F Fermentation respiration switch protein HZR83_RS08600 ENOG4105FCK Membrane HZR83_RS08610 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HZR83_RS08620 ENOG4105DFP Integrase HZR83_RS08740 ENOG4107XAN XdhC and CoxI family HZR83_RS08745 ENOG4105C7W Xanthine dehydrogenase HZR83_RS08750 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HZR83_RS08755 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HZR83_RS08760 ENOG4105R3P Inner membrane protein yagU HZR83_RS08765 ENOG4105PI0 Ferredoxin HZR83_RS08770 ENOG4108UD7 cell wall organization HZR83_RS08775 ENOG4106PYX Receptor HZR83_RS08780 ENOG4108N3D putative enzyme HZR83_RS08790 ENOG4108GWT fimbrillin MatB HZR83_RS08795 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HZR83_RS08835 ENOG4108KBJ Inner membrane protein YkgB HZR83_RS08840 ENOG41066GK UPF0379 protein ykgI HZR83_RS08845 ENOG4107QN2 dihydrolipoyl dehydrogenase HZR83_RS08850 ENOG4108K01 transcriptional regulator HZR83_RS08855 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HZR83_RS08860 ENOG4107QR9 Iron-sulfur cluster binding protein HZR83_RS08865 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HZR83_RS08875 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HZR83_RS08880 ENOG4105C26 Dehydrogenase HZR83_RS08885 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HZR83_RS08890 ENOG4105C94 Transporter HZR83_RS08900 ENOG4105BZU Histidine kinase HZR83_RS08905 ENOG4108NUU Transcriptional regulator HZR83_RS08910 ENOG4105SZ2 membrAne HZR83_RS08915 ENOG4107SNB ankyrin repeat protein YahD HZR83_RS08920 ENOG4105N16 Protein of unknown function (DUF2877) HZR83_RS08925 ENOG4107R1Q Membrane protein FdrA HZR83_RS08930 ENOG4107REC cytoplasmic protein HZR83_RS08940 ENOG4105C5B carbamate kinase HZR83_RS08945 ENOG4105DZC cytosine deaminase HZR83_RS08950 ENOG4105DQ4 alcohol dehydrogenase HZR83_RS08965 ENOG4105E82 cytochrome subunit of dehydrogenase HZR83_RS08970 ENOG4105TDT uncharacterized protein yahO HZR83_RS08975 ENOG4108JU7 Transcriptional regulator HZR83_RS08980 ENOG4105CR4 methylisocitrate lyase HZR83_RS08985 ENOG4105BZN citrate synthase HZR83_RS08990 ENOG4105DXD 2-methylcitrate dehydratase HZR83_RS08995 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HZR83_RS09000 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HZR83_RS09005 ENOG4105DZC cytosine deaminase HZR83_RS09010 ENOG4105DND Transcriptional regulator HZR83_RS09015 ENOG4107B2H carbonic anhydrase HZR83_RS09020 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HZR83_RS09025 ENOG4105DJ2 Major Facilitator Superfamily HZR83_RS09030 ENOG4108UW5 maltose o-acetyltransferase HZR83_RS09035 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HZR83_RS09040 ENOG4105CNT hydrolase family 2 HZR83_RS09045 ENOG4105ETE Transcriptional regulator (LacI family HZR83_RS09050 ENOG4108K2P TRANSCRIPTIONal HZR83_RS09055 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HZR83_RS09065 ENOG4106HB6 Alpha beta hydrolase HZR83_RS09070 ENOG4105IKQ hydratase HZR83_RS09085 ENOG4108SC4 )-transporter HZR83_RS09090 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HZR83_RS09095 ENOG4105C4W S-formylglutathione hydrolase HZR83_RS09110 ENOG4105SRB Uncharacterized protein yaiO HZR83_RS09120 ENOG4108PBI Polysaccharide metabolism HZR83_RS09125 ENOG4107W19 lmbE family HZR83_RS09130 ENOG4106FTQ Taurine ABC transporter, periplasmic HZR83_RS09140 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HZR83_RS09145 ENOG4105E2B Taurine dioxygenase HZR83_RS09150 ENOG4105D52 delta-aminolevulinic acid dehydratase HZR83_RS09160 ENOG4108PNB DNA-binding transcriptional regulator HZR83_RS09165 ENOG4107R6D beta-lactam binding protein AmpH HZR83_RS09170 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HZR83_RS09175 ENOG4107QS8 (LipO)protein HZR83_RS09180 ENOG4105FR5 inner membrane protein YaiY HZR83_RS09185 ENOG4105UNH Membrane HZR83_RS09190 ENOG4105CPF Cell wall formation (By similarity) HZR83_RS09205 ENOG4105G6Z alkaline phosphatase HZR83_RS09210 ENOG4105VIF phosphate starvation-inducible protein HZR83_RS09215 ENOG4105BZU Histidine kinase HZR83_RS09220 ENOG4105II7 pyrroline-5-carboxylate reductase HZR83_RS09235 ENOG4105SS3 HZR83_RS09240 ENOG4105HBA AroM protein HZR83_RS09265 ENOG4105DKQ ROK family HZR83_RS09270 ENOG4105F27 Major Facilitator HZR83_RS09275 ENOG4105EYH Exonuclease HZR83_RS09280 ENOG4107RH8 nuclease SbcCD subunit D HZR83_RS09285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HZR83_RS09290 ENOG4105BZU Histidine kinase HZR83_RS09295 ENOG4105CWM branched-chain amino acid transport system II carrier protein HZR83_RS09300 ENOG4105C85 amino acid HZR83_RS09305 ENOG4107R28 alpha amylase, catalytic region HZR83_RS09310 ENOG4108ZYK Acyl carrier protein phosphodiesterase HZR83_RS09325 ENOG4105VIE preprotein translocase, subunit YajC HZR83_RS09330 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HZR83_RS09335 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HZR83_RS09340 ENOG4105N1F Hnh endonuclease HZR83_RS09345 ENOG4105DRB nucleoside-specific channel-forming protein HZR83_RS09350 ENOG4108KIC (LipO)protein HZR83_RS09360 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HZR83_RS09365 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HZR83_RS09375 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HZR83_RS09380 ENOG4108ZAI phosphatidylglycerophosphatase a HZR83_RS09385 ENOG4105CPC Aldo Keto reductase HZR83_RS09390 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HZR83_RS09395 ENOG4105CTB Polyprenyl synthetase HZR83_RS09405 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HZR83_RS09410 ENOG4107S0N DJ-1 family HZR83_RS09415 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HZR83_RS09425 ENOG4107RDB Major Facilitator HZR83_RS09435 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HZR83_RS09440 ENOG4105CCU oxidase (Subunit III) HZR83_RS09445 ENOG4105BZ9 Cytochrome C oxidase, subunit I HZR83_RS09450 ENOG4105E2S oxidase) subunit II HZR83_RS09455 ENOG4105EYM Major Facilitator superfamily HZR83_RS09460 ENOG4105IEY (LipO)protein HZR83_RS09465 ENOG4105M85 Bola protein HZR83_RS09485 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HZR83_RS09490 ENOG4105K70 DNA-binding protein HZR83_RS09495 ENOG4105EIN peptidylprolyl cis-trans isomerase HZR83_RS09500 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HZR83_RS09505 ENOG4108TGP Thioesterase superfamily protein HZR83_RS09510 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HZR83_RS09515 ENOG4108NFA extracellular solute-binding protein HZR83_RS09520 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HZR83_RS09525 ENOG4108XM1 transcriptional regulator AsnC family HZR83_RS09530 ENOG4105BZ1 (ABC) transporter HZR83_RS09535 ENOG4105BZ1 (ABC) transporter HZR83_RS09540 ENOG4108YZA Nitrogen regulatory protein pii HZR83_RS09545 ENOG4105BZU Histidine kinase HZR83_RS09550 ENOG4105C29 acyl-CoA thioesterase HZR83_RS09555 ENOG4108MNP Glycoprotein polysaccharide metabolism HZR83_RS09560 ENOG41080UX Methyltransferase HZR83_RS09570 ENOG4105KCV RNA signal recognition particle 4.5S RNA HZR83_RS09575 ENOG41066DG (EAL) domain protein HZR83_RS09580 ENOG4105GSJ Inner membrane protein ylaC HZR83_RS09585 ENOG4108UW5 maltose o-acetyltransferase HZR83_RS09590 ENOG4105KF5 hemolysin expression-modulating protein HZR83_RS09595 ENOG4108UKR Biofilm formation regulator YbaJ HZR83_RS09600 ENOG4105BZS acriflavin resistance protein HZR83_RS09605 ENOG4105C1P efflux transporter, rnd family, mfp subunit HZR83_RS09610 ENOG4107XI7 Tetr family transcriptional regulator HZR83_RS09615 ENOG4105EGS Mechanosensitive ion channel HZR83_RS09620 ENOG4106428 Protein of unknown function (DUF2496) HZR83_RS09625 ENOG4108URS primosomal replication protein n'' HZR83_RS09630 ENOG4105WD1 Membrane HZR83_RS09640 ENOG4107QMP dna polymerase iii subunits gamma and tau HZR83_RS09665 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HZR83_RS09675 ENOG4107RE1 Inosine-guanosine kinase HZR83_RS09680 ENOG4105CKD glutathione-regulated potassium-efflux system protein HZR83_RS09685 ENOG4105EU0 Major facilitator Superfamily HZR83_RS09690 ENOG4105CGH 5'-nucleotidase HZR83_RS09695 ENOG4108Z66 YbaK ebsC protein HZR83_RS09700 ENOG4105MBR gumn family HZR83_RS09705 ENOG41081XE plasmid maintenance system antidote protein, xre family HZR83_RS09710 ENOG4105C59 p-type ATPase HZR83_RS09715 ENOG4105CSV Glutaminase HZR83_RS09720 ENOG4107RY6 amino acid HZR83_RS09725 ENOG4108Z6Z Transcriptional regulator HZR83_RS09730 ENOG4105G5H Membrane HZR83_RS09735 ENOG4107QX8 SPFH domain, Band 7 family protein HZR83_RS09740 ENOG41083J0 (ABC) transporter HZR83_RS09745 ENOG4105C4B ABC transporter, permease HZR83_RS09750 ENOG4107QR8 Thioredoxin HZR83_RS09755 ENOG4105E1F short-chain dehydrogenase reductase HZR83_RS09760 ENOG4108UJV acyl-CoA thioesterase i HZR83_RS09765 ENOG4108I0Y (ABC) transporter HZR83_RS09770 ENOG4105CV6 ABC transporter, permease HZR83_RS09775 ENOG4105CNA YD repeat protein HZR83_RS09805 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HZR83_RS09810 ENOG4107653 Transcriptional regulator HZR83_RS09820 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HZR83_RS09825 ENOG41060W2 glyoxylate carboligase HZR83_RS09830 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HZR83_RS09835 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HZR83_RS09840 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HZR83_RS09845 ENOG4105CD3 dihydroorotase HZR83_RS09850 ENOG4105DTE Xanthine uracil vitamin C permease HZR83_RS09855 ENOG4105BZW Glycerate kinase HZR83_RS09860 ENOG4105S0E allantoin catabolism protein HZR83_RS09865 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HZR83_RS09870 ENOG4105DG4 malate L-lactate dehydrogenase HZR83_RS09875 ENOG4107R1Q Membrane protein FdrA HZR83_RS09880 ENOG4107REC cytoplasmic protein HZR83_RS09885 ENOG4105G5A Protein of unknown function (DUF2877) HZR83_RS09890 ENOG4105C5B carbamate kinase HZR83_RS09895 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HZR83_RS09900 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HZR83_RS09910 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HZR83_RS09915 ENOG4105C8N cysteinyl-tRNA synthetase HZR83_RS09920 ENOG4105S2T inner membrane protein YbcI HZR83_RS09925 ENOG4105WQ3 Rna-binding protein HZR83_RS09930 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HZR83_RS09935 ENOG4108WDE Fimbrial protein HZR83_RS09940 ENOG4108AF8 Chaperone HZR83_RS09945 ENOG4105CW0 outer membrane usher protein HZR83_RS09950 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HZR83_RS09955 ENOG4108ZI2 Fimbrial protein HZR83_RS09960 ENOG4108Q9V regulatoR HZR83_RS09975 ENOG4105QUW HZR83_RS09980 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HZR83_RS09985 ENOG410802X bacteriophage n4 adsorption protein b HZR83_RS09990 ENOG4105GR3 Histidine kinase HZR83_RS09995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HZR83_RS10000 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HZR83_RS10005 ENOG410624V efflux system protein HZR83_RS10010 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HZR83_RS10015 ENOG4108IJF Heavy metal efflux pump, CzcA HZR83_RS10020 ENOG4105C85 amino acid HZR83_RS10025 ENOG4105CUY Mechanosensitive ion channel HZR83_RS10030 ENOG4108RCM Nitroreductase HZR83_RS10035 ENOG4108BUD transposase HZR83_RS10045 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HZR83_RS10050 ENOG4105CMR udp-glucose 4-epimerase HZR83_RS10070 ENOG4105CPK Glycosyl transferase (Group 1 HZR83_RS10075 ENOG4105CGN Glycosyl transferase (Group 1 HZR83_RS10085 ENOG4107T8Q Glycosyl transferase (Group 1 HZR83_RS10100 ENOG4105HVQ Regulatory factor of maltose metabolism HZR83_RS10115 ENOG4108BUD transposase HZR83_RS10120 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HZR83_RS10125 ENOG4107635 Hok Gef family protein HZR83_RS10130 ENOG4108SER Transposase HZR83_RS10135 ENOG4108TSE Transferase HZR83_RS10140 ENOG4107RNH Outer membrane receptor FepA HZR83_RS10150 ENOG4105E93 esterase HZR83_RS10155 ENOG41085A6 mbth domain-containing protein HZR83_RS10160 ENOG4105C0W non-ribosomal peptide synthetase HZR83_RS10165 ENOG4108QY5 Ferric enterobactin transport protein HZR83_RS10170 ENOG4105E0A ABC, transporter HZR83_RS10175 ENOG4105TVJ transport system, permease HZR83_RS10180 ENOG4105DQ5 transport system permease protein HZR83_RS10190 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HZR83_RS10195 ENOG4105E4F Isochorismate synthase HZR83_RS10200 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HZR83_RS10205 ENOG4105WQI isochorismatase HZR83_RS10210 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HZR83_RS10215 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HZR83_RS10220 ENOG4105D22 carbon starvation protein HZR83_RS10225 ENOG4105VCD cytoplasmic protein HZR83_RS10230 ENOG4107SCQ Iron-containing alcohol dehydrogenase HZR83_RS10235 ENOG4105CHM Aminotransferase HZR83_RS10240 ENOG4105GTN ParB Domain Protein Nuclease HZR83_RS10245 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HZR83_RS10250 ENOG4105DQS Transcriptional regulator HZR83_RS10255 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HZR83_RS10260 ENOG4105D3R alkyl hydroperoxide reductase HZR83_RS10265 ENOG4108JU3 Alkyl hydroperoxide reductase HZR83_RS10270 ENOG4108U51 Universal stress protein HZR83_RS10275 ENOG4105E2A Dehydrogenase HZR83_RS10280 ENOG4105NXH GreA GreB family elongation factor HZR83_RS10285 ENOG4105KTS ribonuclease HZR83_RS10290 ENOG4107QPK )-transporter HZR83_RS10305 ENOG4105CHY citrate lyase, alpha HZR83_RS10310 ENOG4105CI0 Citrate lyase HZR83_RS10320 ENOG4105DUA (citrate (pro-3S)-lyase ligase HZR83_RS10325 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HZR83_RS10330 ENOG4106YYS transcriptional regulatory protein HZR83_RS10335 ENOG4105CEE C4-dicarboxylate transporter HZR83_RS10340 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HZR83_RS10360 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HZR83_RS10370 ENOG41064T2 transcriptional regulator, lysR family HZR83_RS10385 ENOG4105DZ1 carboxypeptidase HZR83_RS10390 ENOG4105K6T rare lipoprotein A HZR83_RS10395 ENOG4105CNI cell division protein FtsW HZR83_RS10400 ENOG4105CJN penicillin-binding protein HZR83_RS10410 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HZR83_RS10415 ENOG4108TGR phosphatase HZR83_RS10425 ENOG4105DJF DNA polymerase III, delta' subunit HZR83_RS10440 ENOG4107PAI alpha helical protein HZR83_RS10445 ENOG4105EUU Sel1 domain protein repeat-containing protein HZR83_RS10450 ENOG41069CF Protein of unknown function (DUF1266) HZR83_RS10455 ENOG4105QFC Hsc56 co-chaperone of HscC HZR83_RS10460 ENOG4107JFD Sel1 repeat HZR83_RS10465 ENOG41069CF Protein of unknown function (DUF1266) HZR83_RS10470 ENOG4105QFC Hsc56 co-chaperone of HscC HZR83_RS10475 ENOG4105F7F Chaperone HZR83_RS10485 ENOG4105CDA abc transporter atp-binding protein HZR83_RS10490 ENOG4105DRP amino acid AbC transporter HZR83_RS10495 ENOG4105EAD ABC transporter HZR83_RS10500 ENOG4107RP9 extracellular solute-binding protein, family 3 HZR83_RS10505 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HZR83_RS10510 ENOG4108JU5 Magnesium and cobalt efflux protein HZR83_RS10520 ENOG4105C9A Phoh family HZR83_RS10530 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HZR83_RS10570 ENOG4105CAQ asparagine synthetase HZR83_RS10575 ENOG4105D4U had-superfamily hydrolase, subfamily iia HZR83_RS10580 ENOG4105E2R ROK family HZR83_RS10585 ENOG4105CE4 GlcNAc 6-P deacetylase HZR83_RS10595 ENOG4105CI1 PTS System HZR83_RS10610 ENOG4105GX6 (LipO)protein HZR83_RS10615 ENOG41090R7 Ferric uptake HZR83_RS10625 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HZR83_RS10630 ENOG4105NNH LexA regulated protein HZR83_RS10635 ENOG4105EV9 Alpha Beta Hydrolase HZR83_RS10640 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HZR83_RS10645 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HZR83_RS10665 ENOG4105D5Q Arginine ornithine antiporter HZR83_RS10680 ENOG4105EEX Two component transcriptional regulator (Winged helix family HZR83_RS10685 ENOG4105C08 Histidine kinase HZR83_RS10690 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HZR83_RS10695 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HZR83_RS10710 ENOG4105XIQ Protein of unknown function (DUF2517) HZR83_RS10715 ENOG4105CNA YD repeat protein HZR83_RS10720 ENOG41079JQ Membrane HZR83_RS10730 ENOG4106R09 HZR83_RS10750 ENOG4107SEY Conserved Protein HZR83_RS10755 ENOG4105CVP deoxyribo-dipyrimidine photolyase HZR83_RS10760 ENOG4105DUX Transporter HZR83_RS10765 ENOG4107QNR UPF0135 protein HZR83_RS10770 ENOG4105P4J Allophanate hydrolase, subunit 1 HZR83_RS10775 ENOG4107R7A Allophanate hydrolase subunit 2 HZR83_RS10780 ENOG4105E7W lamb ycsf family protein HZR83_RS10785 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HZR83_RS10790 ENOG4108KK1 membrane protein AbrB duplication HZR83_RS10795 ENOG4108MY7 Fimbrial HZR83_RS10800 ENOG4108TTM chaperone HZR83_RS10805 ENOG4106PG1 outer membrane usher protein HZR83_RS10810 ENOG4106UBK fimbrial-like adhesin protein HZR83_RS10815 ENOG4105BZN citrate synthase HZR83_RS10825 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HZR83_RS10830 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HZR83_RS10835 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HZR83_RS10840 ENOG4105E33 succinate dehydrogenase HZR83_RS10845 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HZR83_RS10850 ENOG4105C7S Dehydrogenase HZR83_RS10860 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HZR83_RS10865 ENOG4105FDP GntR family transcriptional regulator HZR83_RS10870 ENOG4105DM4 PTS System HZR83_RS10875 ENOG4105C8I hydrolase, family 38 HZR83_RS10885 ENOG4105C4M (Ubiquinol oxidase) subunit I HZR83_RS10890 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HZR83_RS10900 ENOG4105KJB cyd operon protein YbgE HZR83_RS10905 ENOG4107YD3 Thioesterase HZR83_RS10910 ENOG4105E02 MotA TolQ exbB proton channel HZR83_RS10920 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HZR83_RS10930 ENOG4105KCK Peptidoglycan-associated lipoprotein HZR83_RS10935 ENOG4105UFD tol-pal system protein YbgF HZR83_RS10980 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HZR83_RS10985 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HZR83_RS10990 ENOG4105PGM cation diffusion facilitator family transporter HZR83_RS10995 ENOG4105JND homeobox protein HZR83_RS11000 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HZR83_RS11010 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HZR83_RS11020 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HZR83_RS11025 ENOG4105CMR udp-glucose 4-epimerase HZR83_RS11030 ENOG4105DKW ABC transporter HZR83_RS11035 ENOG4105F4R Transcriptional regulator mode HZR83_RS11045 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HZR83_RS11050 ENOG4105E0C molybdate abc transporter HZR83_RS11055 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HZR83_RS11060 ENOG4108K4B hydrolase HZR83_RS11070 ENOG4105F04 LysR family Transcriptional regulator HZR83_RS11075 ENOG4105C7F AcnD-accessory protein PrpF HZR83_RS11080 ENOG4107QPK )-transporter HZR83_RS11085 ENOG4107QM5 aconitate hydratase HZR83_RS11090 ENOG4105NBR Pectinesterase HZR83_RS11095 ENOG4108V1U phospholipid-binding protein HZR83_RS11100 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HZR83_RS11110 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HZR83_RS11115 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HZR83_RS11120 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HZR83_RS11130 ENOG4105CHW UPF0052 protein HZR83_RS11140 ENOG4108RIR Molybdenum cofactor biosynthesis protein HZR83_RS11150 ENOG4105M00 molybdopterin converting factor, subunit 1 HZR83_RS11155 ENOG4108ZAF Molybdopterin HZR83_RS11160 ENOG4105HFZ Membrane HZR83_RS11165 ENOG410733J conserved inner membrane protein HZR83_RS11170 ENOG4107UXM Membrane HZR83_RS11175 ENOG4105DZQ phospholipase D Transphosphatidylase HZR83_RS11180 ENOG4105X23 Endonuclease Exonuclease phosphatase HZR83_RS11185 ENOG4105I9U inner membrane protein ybhQ HZR83_RS11190 ENOG4107QWP ABC-2 type transporter HZR83_RS11195 ENOG4107QWP ABC-2 type transporter HZR83_RS11200 ENOG4105CJ1 ABC, transporter HZR83_RS11210 ENOG4107MVR Transcriptional regulator HZR83_RS11215 ENOG4105C1J atp-dependent rna helicase HZR83_RS11225 ENOG4105DVT helicase HZR83_RS11230 ENOG4108MTB glycosyl transferase family HZR83_RS11235 ENOG4105DG4 malate L-lactate dehydrogenase HZR83_RS11240 ENOG4105VR4 UPF0379 protein ybiJ HZR83_RS11245 ENOG4105KSC Transcriptional regulator, TraR DksA family HZR83_RS11255 ENOG4108IU3 tonb-dependent siderophore receptor HZR83_RS11260 ENOG4105ZY9 UPF0379 protein ybiM HZR83_RS11270 ENOG4105D8X mechanosensitive ion channel HZR83_RS11275 ENOG4105CDA abc transporter atp-binding protein HZR83_RS11280 ENOG4105E5Q amino acid AbC transporter HZR83_RS11285 ENOG4107R0W ABC transporter HZR83_RS11295 ENOG4107AQZ Membrane HZR83_RS11305 ENOG4108T1M outer membrane protein x HZR83_RS11310 ENOG4108I6E Sulfatase HZR83_RS11320 ENOG4105KST dependent repressor HZR83_RS11325 ENOG4105F4P )-transporter HZR83_RS11330 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HZR83_RS11335 ENOG4105C5H ABC transporter HZR83_RS11340 ENOG41072TH Protein of unknown function (DUF1479) HZR83_RS11345 ENOG4108HCJ Hydrolase HZR83_RS11355 ENOG4105F1A Pyruvate formate-lyase HZR83_RS11360 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HZR83_RS11365 ENOG4105D06 uba thif-type nad fad binding protein HZR83_RS11370 ENOG4105CVM Molybdenum cofactor synthesis domain protein HZR83_RS11375 ENOG4105D44 asparaginase HZR83_RS11380 ENOG4108JQ6 ABC transporter HZR83_RS11385 ENOG4105DEF Extracellular solute-binding protein, family 5 HZR83_RS11395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZR83_RS11400 ENOG4105BZU Histidine kinase HZR83_RS11405 ENOG41064RH membrane protein YliF HZR83_RS11415 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HZR83_RS11420 ENOG4105D8V Glucose sorbosone dehydrogenase HZR83_RS11425 ENOG4108TGY Glutathione S-transferase HZR83_RS11430 ENOG4105DZ1 carboxypeptidase HZR83_RS11435 ENOG4107FB0 transcriptional regulator DeoR family HZR83_RS11440 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HZR83_RS11445 ENOG4107QF7 multi-drug HZR83_RS11455 ENOG4108HCJ Hydrolase HZR83_RS11460 ENOG4106UW1 Major Facilitator superfamily HZR83_RS11465 ENOG4108RFG Tetr family transcriptional regulator HZR83_RS11475 ENOG4105GWF inner membrane protein YbjM HZR83_RS11480 ENOG41090BQ Glutaredoxin HZR83_RS11485 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HZR83_RS11490 ENOG4108DBC nitroreductase HZR83_RS11500 ENOG4108RMJ sensory transduction regulator HZR83_RS11505 ENOG4107RUE extracellular solute-binding protein family 1 HZR83_RS11510 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HZR83_RS11515 ENOG4105F38 ABC transporter, permease HZR83_RS11520 ENOG4105D38 putrescine abc transporter HZR83_RS11525 ENOG4105RBQ inner membrane protein ybjO HZR83_RS11530 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HZR83_RS11535 ENOG4106TNF Periplasmic binding protein HZR83_RS11540 ENOG4105DMR ABC, transporter HZR83_RS11545 ENOG4105GBT ABC transporter HZR83_RS11550 ENOG4106PMH Extracellular solute-binding protein family 3 HZR83_RS11555 ENOG4105E5Z arginine transporter ATP-binding subunit HZR83_RS11560 ENOG41064MM (LipO)protein HZR83_RS11570 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HZR83_RS11575 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HZR83_RS11580 ENOG4105CGD Nad-dependent epimerase dehydratase HZR83_RS11585 ENOG4105C5W Aldolase HZR83_RS11590 ENOG4105C7K acetolactate synthase HZR83_RS11595 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HZR83_RS11605 ENOG4105DWU Membrane HZR83_RS11610 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HZR83_RS11615 ENOG4105CPB ATP-dependent endonuclease of the OLD family HZR83_RS11620 ENOG4108MJ5 VirK protein HZR83_RS11625 ENOG4105DJY efflux transporter, rnd family, mfp subunit HZR83_RS11630 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HZR83_RS11635 ENOG4105VEQ Cold shock protein HZR83_RS11645 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HZR83_RS11655 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HZR83_RS11665 ENOG4108JJ8 (ABC) transporter HZR83_RS11670 ENOG4108JJ9 ABC, transporter HZR83_RS11675 ENOG4105C3M thioredoxin reductase HZR83_RS11685 ENOG4105CNU cell division protein FtsK HZR83_RS11695 ENOG4105D1H recombination factor protein RarA HZR83_RS11705 ENOG4107QY8 reductase HZR83_RS11710 ENOG4105QAX Iron-sulfur HZR83_RS11715 ENOG4107KGK dmso reductase anchor subunit HZR83_RS11720 ENOG4105CHJ isochorismatase hydrolase HZR83_RS11730 ENOG4105E5D amino acid HZR83_RS11735 ENOG410642W LysR family Transcriptional regulator HZR83_RS11740 ENOG4108X0B nad(p)h dehydrogenase (quinone) HZR83_RS11745 ENOG4105F1A Pyruvate formate-lyase HZR83_RS11750 ENOG4105C6N Formate acetyltransferase HZR83_RS11755 ENOG4105TMB Formate nitrite transporter HZR83_RS11760 ENOG4105DDY UPF0142 protein ycaO HZR83_RS11765 ENOG4107VMU Membrane HZR83_RS11770 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HZR83_RS11780 ENOG4108K0D peptidase, M48 HZR83_RS11790 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HZR83_RS11800 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HZR83_RS11805 ENOG4105BZ1 (ABC) transporter HZR83_RS11810 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HZR83_RS11815 ENOG4105T0Z Conserved Protein HZR83_RS11830 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HZR83_RS11835 ENOG4107S90 membrAne HZR83_RS11840 ENOG4106371 Methyltransferase HZR83_RS11850 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HZR83_RS11855 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HZR83_RS11860 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HZR83_RS11865 ENOG4105EAQ (twin-arginine translocation) pathway signal HZR83_RS11870 ENOG4105C5X domain protein HZR83_RS11875 ENOG4105CGF Aromatic amino acid aminotransferase HZR83_RS11880 ENOG4105FCK Membrane HZR83_RS11890 ENOG4107RH7 Nicotinate phosphoribosyltransferase HZR83_RS11895 ENOG4105CD8 aminopeptidase N HZR83_RS11900 ENOG4105E2Y ABC, transporter HZR83_RS11905 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HZR83_RS11915 ENOG4105GVF (ABC) transporter HZR83_RS11920 ENOG4108UZX fmn reductase HZR83_RS11925 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HZR83_RS11930 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HZR83_RS11935 ENOG4105CW0 outer membrane usher protein HZR83_RS11940 ENOG4108MDY Fimbrial HZR83_RS11945 ENOG4105Q7J Fimbrial HZR83_RS11950 ENOG4105MX3 Fimbrial HZR83_RS11955 ENOG4106PH7 chaperone HZR83_RS11965 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HZR83_RS11970 ENOG4105QVC MOSC domain-containing protein HZR83_RS11980 ENOG4105C5H ABC transporter HZR83_RS11985 ENOG4105F1S paraquat-inducible protein a HZR83_RS11990 ENOG4105DY2 Paraquat-inducible protein b HZR83_RS11995 ENOG4108Q2G (LipO)protein HZR83_RS12000 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HZR83_RS12010 ENOG4105DAN ATP-dependent protease HZR83_RS12020 ENOG4105UYK outer membrane protein a HZR83_RS12030 ENOG4108RZ1 DNA transformation protein HZR83_RS12035 ENOG4105EM2 membrane HZR83_RS12040 ENOG410901E Membrane HZR83_RS12045 ENOG41088T4 Helicase IV HZR83_RS12060 ENOG4105K4P CoA-binding domain protein HZR83_RS12075 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HZR83_RS12080 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HZR83_RS12085 ENOG4108MN8 Membrane HZR83_RS12095 ENOG4105E3S small subunit HZR83_RS12100 ENOG4105DPX Hydrogenase, large subunit HZR83_RS12105 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HZR83_RS12110 ENOG4108USZ hydrogenase HZR83_RS12115 ENOG4108VXY Hydrogenase-1 operon protein HyaE HZR83_RS12120 ENOG4105MVP hydrogenase-1 operon protein HyaF HZR83_RS12125 ENOG4105C4M (Ubiquinol oxidase) subunit I HZR83_RS12130 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HZR83_RS12140 ENOG4105D6F Phosphatase HZR83_RS12145 ENOG4105D75 Capsular exopolysaccharide family HZR83_RS12150 ENOG4107ZF2 Phosphatase HZR83_RS12155 ENOG4105DAY polysaccharide export protein HZR83_RS12160 ENOG4105E3R (LipO)protein HZR83_RS12165 ENOG4108W78 Pfam:DUF1017 HZR83_RS12170 ENOG4108Y9B (LipO)protein HZR83_RS12180 ENOG41060EU Cold shock-like protein HZR83_RS12185 ENOG4105VEQ Cold shock protein HZR83_RS12200 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HZR83_RS12205 ENOG4105HEE Binding Domain protein HZR83_RS12210 ENOG4105BZU Histidine kinase HZR83_RS12215 ENOG4108SV3 Tmao reductase system periplasmic protein tort HZR83_RS12220 ENOG4106WF9 DNA-binding transcriptional regulator TorR HZR83_RS12225 ENOG4105CUW cytochrome C-TYPE protein HZR83_RS12230 ENOG4107QY8 reductase HZR83_RS12235 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) HZR83_RS12255 ENOG4105D6F Phosphatase HZR83_RS12260 ENOG4105XH3 HZR83_RS12270 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HZR83_RS12275 ENOG4105C2W permease HZR83_RS12280 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HZR83_RS12285 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HZR83_RS12290 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HZR83_RS12300 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HZR83_RS12305 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HZR83_RS12310 ENOG4108R86 Transcriptional regulator HZR83_RS12315 ENOG4105C26 Dehydrogenase HZR83_RS12325 ENOG4105CK7 Sodium proline symporter HZR83_RS12335 ENOG410650H (LipO)protein HZR83_RS12340 ENOG4105DBE peroxidase HZR83_RS12345 ENOG4105D5M phosphate starvation-inducible protein HZR83_RS12355 ENOG4105CND Glycosyl transferase, family 2 HZR83_RS12360 ENOG4107BJW polysaccharide deacetylase HZR83_RS12365 ENOG4108TUY outer membrane protein PgaA HZR83_RS12370 ENOG4105BZU Histidine kinase HZR83_RS12385 ENOG4108T85 Membrane HZR83_RS12400 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HZR83_RS12405 ENOG4107SSZ Phosphatase HZR83_RS12410 ENOG4107XHZ cytoplasmic chaperone TorD family protein HZR83_RS12415 ENOG4108UQ5 membrane protein YcdZ HZR83_RS12420 ENOG4105P8Q Curli production assembly transport component CsgG HZR83_RS12425 ENOG4108WYR Curli production assembly transport component, CsgF HZR83_RS12430 ENOG4108XDW curli assembly protein CsgE HZR83_RS12435 ENOG41086KC Transcriptional regulator HZR83_RS12440 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HZR83_RS12445 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HZR83_RS12450 ENOG4108RS6 transposase HZR83_RS12455 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HZR83_RS12465 ENOG4108UVJ appr-1-p processing domain protein HZR83_RS12470 ENOG4107RZC phospholipase d HZR83_RS12475 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HZR83_RS12480 ENOG4105DJ9 glucan biosynthesis protein HZR83_RS12485 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HZR83_RS12490 ENOG4105NAC (LipO)protein HZR83_RS12495 ENOG4108W47 Acidic protein msyB HZR83_RS12505 ENOG4105D1S lipid A biosynthesis HZR83_RS12510 ENOG4105C72 UPF0176 protein HZR83_RS12515 ENOG4108YYC ycei family HZR83_RS12520 ENOG4105DS1 cytochrome b561 HZR83_RS12525 ENOG4106974 biofilm formation HZR83_RS12530 ENOG4105F76 Sarcosine oxidase HZR83_RS12535 ENOG4105PVA Biofilm formation regulatory protein BssS HZR83_RS12540 ENOG4105MEA DNA damage-inducible protein i HZR83_RS12545 ENOG4105EKE dihydroorotase HZR83_RS12550 ENOG4105F3T (LipO)protein HZR83_RS12555 ENOG4105E9S glutaredoxin 2 HZR83_RS12565 ENOG4105D9U N-acetyltransferase HZR83_RS12570 ENOG4108YXG UPF0502 protein HZR83_RS12575 ENOG4105EP9 oxidoreductase HZR83_RS12580 ENOG4105CJR Integral membrane protein (MviN HZR83_RS12585 ENOG4105QVD Flagella synthesis protein FlgN HZR83_RS12590 ENOG4105M9M anti-sigma28 factor FlgM HZR83_RS12595 ENOG4105CKS Flagella basal body P-ring formation protein flgA HZR83_RS12600 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HZR83_RS12605 ENOG4108ZC9 flagellar basal-body rod protein flgc HZR83_RS12610 ENOG4105W00 Flagellar hook capping protein HZR83_RS12615 ENOG4105BZE flagellar hook protein, FlgE HZR83_RS12625 ENOG4105CGA flagellar basal-body rod protein FlgG HZR83_RS12640 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HZR83_RS12645 ENOG4105E1Q flagellar hook-associated protein HZR83_RS12650 ENOG4105DTJ flagellar hook-associated protein HZR83_RS12655 ENOG4107QQB Ribonuclease E HZR83_RS12665 ENOG4105EI2 Pseudouridine synthase HZR83_RS12670 ENOG4108UHJ MAF-like protein HZR83_RS12675 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HZR83_RS12695 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HZR83_RS12700 ENOG4105CHR reductase HZR83_RS12705 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HZR83_RS12710 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HZR83_RS12715 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HZR83_RS12720 ENOG4105HHA aminodeoxychorismate lyase HZR83_RS12730 ENOG4107QRG dna polymerase iii HZR83_RS12735 ENOG4105F8V Hydrolase, tatD family HZR83_RS12740 ENOG4105CI1 PTS System HZR83_RS12745 ENOG4105CNM Receptor HZR83_RS12750 ENOG4105K59 histidine triad (HIT) protein HZR83_RS12755 ENOG41090DQ Lipoprotein HZR83_RS12760 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HZR83_RS12765 ENOG4108RUM thiamine kinase HZR83_RS12770 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HZR83_RS12780 ENOG4105CEP NADH dehydrogenase HZR83_RS12785 ENOG4107MBR 17 kDa surface antigen HZR83_RS12790 ENOG4108IND Tetr family transcriptional regulator HZR83_RS12795 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HZR83_RS12800 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HZR83_RS12805 ENOG4108JA2 transcriptioN-repair coupling factor HZR83_RS12810 ENOG4105IQC Inner membrane protein YcfT HZR83_RS12815 ENOG4105D60 lipoprotein releasing system transmembrane protein HZR83_RS12820 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HZR83_RS12825 ENOG4105D60 lipoprotein releasing system transmembrane protein HZR83_RS12835 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HZR83_RS12850 ENOG4107RUE extracellular solute-binding protein family 1 HZR83_RS12855 ENOG4105D38 putrescine abc transporter HZR83_RS12860 ENOG4108I1J Integrase HZR83_RS12870 ENOG41076J9 exonuclease VIII HZR83_RS12875 ENOG4106G8A Qin prophage HZR83_RS12910 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HZR83_RS12945 ENOG4108MXB Protein of unknown function (DUF968) HZR83_RS12950 ENOG4105KSK (crossover) junction endodeoxyribonuclease HZR83_RS12955 ENOG4105HGD Antitermination protein HZR83_RS12990 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HZR83_RS13010 ENOG4105QYK bacteriophage lambda Bor protein homolog HZR83_RS13150 ENOG4108WF3 methyltransferase HZR83_RS13165 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HZR83_RS13170 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HZR83_RS13175 ENOG4105EZE Cupin 4 family protein HZR83_RS13180 ENOG4105IFJ Histidine kinase HZR83_RS13185 ENOG4105XJC Two component transcriptional regulator (Winged helix family HZR83_RS13190 ENOG4107QTF adenylosuccinate lyase HZR83_RS13210 ENOG4108R99 pseudouridine synthase HZR83_RS13215 ENOG4108HMX isocitrate dehydrogenase (NADP) HZR83_RS13220 ENOG41066T8 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity) HZR83_RS13235 ENOG41064WM Uncharacterized protein YcgX HZR83_RS13240 ENOG4108XDN Transcriptional regulator HZR83_RS13245 ENOG4105BZU Histidine kinase HZR83_RS13250 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HZR83_RS13255 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HZR83_RS13265 ENOG410738I uncharacterized protein ymgC HZR83_RS13270 ENOG4105BZU Histidine kinase HZR83_RS13320 ENOG4107QMS site-determining protein HZR83_RS13325 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HZR83_RS13330 ENOG4105S66 prophage protein HZR83_RS13335 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HZR83_RS13350 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HZR83_RS13360 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HZR83_RS13365 ENOG4105KT5 UmuD protein HZR83_RS13370 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HZR83_RS13375 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HZR83_RS13390 ENOG4105ED1 spovr family HZR83_RS13400 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HZR83_RS13410 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HZR83_RS13415 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HZR83_RS13420 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HZR83_RS13425 ENOG4105Y3U Transglycosylase-associated protein HZR83_RS13440 ENOG4105VDH Dihydroxyacetone kinase HZR83_RS13445 ENOG4108UTZ Dihydroxyacetone kinase HZR83_RS13450 ENOG4105CMT Dihydroxyacetone kinase HZR83_RS13455 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HZR83_RS13460 ENOG4105I1J Autotransporter HZR83_RS13465 ENOG4105C3G gtp-binding protein HZR83_RS13475 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HZR83_RS13480 ENOG4105CHH sulfate transporter HZR83_RS13485 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HZR83_RS13490 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HZR83_RS13500 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HZR83_RS13510 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HZR83_RS13515 ENOG4108YY7 Invasion gene expression up-regulator SirB HZR83_RS13520 ENOG41063JG Transcriptional regulator HZR83_RS13545 ENOG4105EWV Sodium calcium exchanger membrane region HZR83_RS13550 ENOG4105WS7 Cation transport regulator HZR83_RS13555 ENOG4108NH8 Cation transport protein HZR83_RS13560 ENOG41090EX DsrE family HZR83_RS13565 ENOG4105ID0 Putative invasin HZR83_RS13570 ENOG4105WH1 Two component transcriptional regulator luxr family HZR83_RS13575 ENOG4105BZU Histidine kinase HZR83_RS13580 ENOG4105DQQ Major facilitator superfamily MFS_1 HZR83_RS13585 ENOG4105CRU nitrate reductase, alpha subunit HZR83_RS13590 ENOG4108IUE nitrate reductase beta subunit HZR83_RS13595 ENOG4105R3A Nitrate reductase HZR83_RS13600 ENOG41076YT nitrate reductase, gamma subunit HZR83_RS13635 ENOG4105CIY formyltetrahydrofolate deformylase HZR83_RS13640 ENOG4105K5B UPF0225 protein HZR83_RS13645 ENOG4105D78 K07001 NTE family protein HZR83_RS13650 ENOG4105I93 response regulator HZR83_RS13655 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HZR83_RS13660 ENOG4108SAU DNA-binding protein H-ns HZR83_RS13665 ENOG4107104 thymidine kinase HZR83_RS13675 ENOG4105C0A alcohol dehydrogenase HZR83_RS13680 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HZR83_RS13690 ENOG4108J59 Extracellular solute-binding protein, family 5 HZR83_RS13695 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HZR83_RS13700 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZR83_RS13705 ENOG4105C3U ABC transporter HZR83_RS13710 ENOG4108JQ7 (ABC) transporter HZR83_RS13730 ENOG4107SVH Potassium channel protein HZR83_RS13735 ENOG4105K9H YciI-like protein HZR83_RS13740 ENOG410822N TonB family HZR83_RS13745 ENOG4105NAU thioesterase Superfamily protein HZR83_RS13755 ENOG4108S3I UPF0259 membrane protein HZR83_RS13765 ENOG4105EIF outer membrane protein W HZR83_RS13770 ENOG4108N8X transition metal ion binding HZR83_RS13775 ENOG4108Z9Z response to DNA damage stimulus HZR83_RS13795 ENOG4105DK0 Indole-3-glycerol phosphate synthase HZR83_RS13800 ENOG4108EFP Anthranilate synthase component II HZR83_RS13805 ENOG4105CRQ synthase (Component I) HZR83_RS13815 ENOG4105DB7 PHP domain protein HZR83_RS13820 ENOG4107RTD sua5 ycio yrdc ywlc family protein HZR83_RS13825 ENOG4105EG3 transmembrane signal peptide protein HZR83_RS13830 ENOG4105FE9 pseudouridine synthase HZR83_RS13835 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HZR83_RS13840 ENOG4105UBK short-chain dehydrogenase reductase HZR83_RS13845 ENOG4105ERU peptidase HZR83_RS13850 ENOG4105RKX Protein of unknown function (DUF2498) HZR83_RS13855 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HZR83_RS13860 ENOG4107R11 Transcriptional regulator HZR83_RS13885 ENOG4107QM5 aconitate hydratase HZR83_RS13895 ENOG4105EYK Phosphatidylglycerophosphatase B HZR83_RS13900 ENOG4105Q4A inner membrane protein yciS HZR83_RS13905 ENOG4105CFV Tetratricopeptide repeat protein HZR83_RS13910 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HZR83_RS13915 ENOG4108ZJT translation initiation factor, Sui1 HZR83_RS13925 ENOG4105N2W Transcriptional regulator HZR83_RS13930 ENOG410643D UPF0509 protein HZR83_RS13935 ENOG4105BZU Histidine kinase HZR83_RS13950 ENOG4105Q4T oxidoreductase HZR83_RS13955 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HZR83_RS13960 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HZR83_RS13965 ENOG4108JQ2 peptide transport system atp-binding protein HZR83_RS13970 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HZR83_RS13975 ENOG4108EU3 peptide transport system, permease HZR83_RS13980 ENOG4108I5W peptide transport system, permease protein HZR83_RS13985 ENOG4108HIY periplasmic HZR83_RS13990 ENOG4105N0E Protein of unknown function (DUF2543) HZR83_RS13995 ENOG4105CUB amino acid HZR83_RS14005 ENOG4105CFQ glutamine synthetase HZR83_RS14010 ENOG4108Z86 Glutamine amidotransferase HZR83_RS14015 ENOG4107VRI Transcriptional regulator HZR83_RS14020 ENOG4105C26 Dehydrogenase HZR83_RS14025 ENOG4105CJP fad dependent oxidoreductase HZR83_RS14030 ENOG4108JPW Aminotransferase HZR83_RS14035 ENOG4105E51 psp operon transcriptional activator HZR83_RS14040 ENOG41087YS Phage shock protein A HZR83_RS14045 ENOG4105YYT phage shock protein B HZR83_RS14050 ENOG4105FM1 phage shock protein C HZR83_RS14055 ENOG4105NNG Peripheral inner membrane phage-shock protein HZR83_RS14060 ENOG4105K8Z Phage shock protein HZR83_RS14065 ENOG4107QW3 Sucrose phosphorylase HZR83_RS14075 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HZR83_RS14080 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HZR83_RS14085 ENOG4107RRD Dehydrogenase HZR83_RS14090 ENOG4107TYA transient receptor potential locus HZR83_RS14095 ENOG4105CK5 oxidoreductase HZR83_RS14100 ENOG4105C71 hydrolase family 65, central catalytic HZR83_RS14105 ENOG4107URF beta-phospho-glucomutase HZR83_RS14115 ENOG4107EFV Outer membrane protein G HZR83_RS14120 ENOG4105FKQ transcriptional regulator HZR83_RS14125 ENOG4105CM6 amino acid regulated cytosolic protein HZR83_RS14135 ENOG4108JU8 Transcriptional regulator HZR83_RS14140 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HZR83_RS14145 ENOG4107S8C mandelate racemase muconate lactonizing HZR83_RS14150 ENOG4105KXI murein peptide amidase A HZR83_RS14165 ENOG4105ENX hydrolase HZR83_RS14170 ENOG4105EQ2 LysR family Transcriptional regulator HZR83_RS14175 ENOG4107QSI ABC, transporter HZR83_RS14180 ENOG4105D64 Mechanosensitive ion channel HZR83_RS14185 ENOG4105S5I Membrane HZR83_RS14190 ENOG4105Q9Y Universal stress protein HZR83_RS14195 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HZR83_RS14200 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HZR83_RS14205 ENOG4105CFC Transporter HZR83_RS14210 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HZR83_RS14215 ENOG4105CH2 amidohydrolase HZR83_RS14220 ENOG4106KR7 LysR family Transcriptional regulator HZR83_RS14225 ENOG4108DG9 Smr protein MutS2 HZR83_RS14230 ENOG4105BZU Histidine kinase HZR83_RS14240 ENOG4105C1J atp-dependent rna helicase HZR83_RS14250 ENOG4108RW8 Universal stress protein F HZR83_RS14255 ENOG4105FCK Membrane HZR83_RS14260 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HZR83_RS14265 ENOG4105IKK cytoplasmic protein HZR83_RS14270 ENOG41090X5 Heat shock protein hslJ HZR83_RS14275 ENOG4105C5I Dehydrogenase HZR83_RS14280 ENOG4107H52 Dicarboxylate transport HZR83_RS14285 ENOG410689M (LipO)protein HZR83_RS14290 ENOG4105WXT Conserved Protein HZR83_RS14295 ENOG4108WFR AraC Family Transcriptional Regulator HZR83_RS14300 ENOG4105C26 Dehydrogenase HZR83_RS14305 ENOG4105F11 amine oxidase HZR83_RS14310 ENOG4105DXM phenylacetic acid degradation protein HZR83_RS14315 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HZR83_RS14320 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HZR83_RS14325 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HZR83_RS14330 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HZR83_RS14335 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HZR83_RS14340 ENOG4105E39 Enoyl-CoA hydratase HZR83_RS14345 ENOG4108UKI Enoyl-CoA hydratase HZR83_RS14350 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HZR83_RS14355 ENOG4108ZJI phenylacetic acid degradation protein HZR83_RS14360 ENOG4105CHU acetyl-coa acetyltransferase HZR83_RS14365 ENOG4105DZS Phenylacetate-CoA ligase HZR83_RS14370 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HZR83_RS14375 ENOG4108Z0R Transferase HZR83_RS14395 ENOG4107EF2 surface-exposed virulence protein HZR83_RS14400 ENOG4107S5I aldo keto reductase HZR83_RS14410 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HZR83_RS14415 ENOG4108HPI phosphatidate Cytidylyltransferase HZR83_RS14420 ENOG4105E8V Alpha Beta Hydrolase Fold protein HZR83_RS14425 ENOG41077RS Phosphatase HZR83_RS14435 ENOG4105CQ7 ATP-dependent helicase HZR83_RS14440 ENOG4107DB1 DUF218 domain HZR83_RS14445 ENOG4105C26 Dehydrogenase HZR83_RS14455 ENOG4105CPW cytochrome b561 HZR83_RS14460 ENOG4105UPP uncharacterized protein ydcA HZR83_RS14465 ENOG4107NK6 Hok/gef family HZR83_RS14470 ENOG4105C8Q Methyl-accepting chemotaxis HZR83_RS14475 ENOG4105DDW LysR family Transcriptional regulator HZR83_RS14480 ENOG4105E32 cytoplasmic protein HZR83_RS14485 ENOG4105DJ9 glucan biosynthesis protein HZR83_RS14490 ENOG4105Z2P Protein of unknown function (DUF465) HZR83_RS14495 ENOG4108Z9I -acetyltransferase HZR83_RS14500 ENOG4107WE3 acetyltransferase YdcK HZR83_RS14505 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HZR83_RS14510 ENOG41088CC tellurite resistance protein tehB HZR83_RS14515 ENOG4108KKZ (LipO)protein HZR83_RS14525 ENOG4105D7V transposase HZR83_RS14530 ENOG4105DKK Benzoate HZR83_RS14535 ENOG4108JCI Transcriptional regulator HZR83_RS14540 ENOG4105CFP Peptidase U32 HZR83_RS14545 ENOG4105RR0 Protein of unknown function (DUF2554) HZR83_RS14555 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HZR83_RS14560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HZR83_RS14565 ENOG4107TYH extracellular solute-binding protein family 1 HZR83_RS14570 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HZR83_RS14575 ENOG4105D81 ABC transporter, permease HZR83_RS14580 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HZR83_RS14595 ENOG410654E Membrane HZR83_RS14600 ENOG4105R71 cytoplasmic protein HZR83_RS14605 ENOG4108T9Y Inner membrane protein ydcZ HZR83_RS14610 ENOG4108Z7F N-acetyltransferase HZR83_RS14615 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HZR83_RS14620 ENOG4108WYP Transcriptional regulator HZR83_RS14625 ENOG4105CHB tonB-dependent Receptor HZR83_RS14630 ENOG4108NS2 receptor HZR83_RS14635 ENOG4105C85 amino acid HZR83_RS14640 ENOG4108N27 Glutathione S-transferase HZR83_RS14650 ENOG4105CS6 Rhs element vgr protein HZR83_RS14655 ENOG4105CNA YD repeat protein HZR83_RS14675 ENOG410600T transposase HZR83_RS14680 ENOG4105KZK Tautomerase pptA HZR83_RS14685 ENOG4108MEJ flavin reductase domain protein HZR83_RS14690 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HZR83_RS14695 ENOG4105JAB phenazine biosynthesis protein, phzf family HZR83_RS14700 ENOG4105D0D Nitrate reductase 2, gamma subunit HZR83_RS14705 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HZR83_RS14710 ENOG4108IUE nitrate reductase beta subunit HZR83_RS14720 ENOG4107QND Nitrite extrusion protein HZR83_RS14735 ENOG4105RPH Inner membrane protein YddG HZR83_RS14745 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HZR83_RS14750 ENOG4108MG3 formate dehydrogenase HZR83_RS14755 ENOG41084S7 Plasmid maintenance system antidote protein HZR83_RS14760 ENOG4105DQ4 alcohol dehydrogenase HZR83_RS14765 ENOG4107R1I NAD-dependent malic enzyme HZR83_RS14770 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HZR83_RS14775 ENOG4105TPS biofilm-dependent modulation protein HZR83_RS14780 ENOG4108Z9K Osmotically inducible protein HZR83_RS14785 ENOG4107H6U ABC transporter HZR83_RS14790 ENOG4105C3U ABC transporter HZR83_RS14795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZR83_RS14800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HZR83_RS14805 ENOG4105DEF Extracellular solute-binding protein, family 5 HZR83_RS14810 ENOG4108UQS dipeptidase HZR83_RS14815 ENOG4105BZU Histidine kinase HZR83_RS14820 ENOG4105BZU Histidine kinase HZR83_RS14830 ENOG4105F32 YngK protein HZR83_RS14835 ENOG4105E5D amino acid HZR83_RS14840 ENOG4105CVK Glutamate decarboxylase HZR83_RS14845 ENOG4107RAN Peptidase, M16 HZR83_RS14850 ENOG4105PE1 Receptor HZR83_RS14855 ENOG4105CQ0 ABC transporter HZR83_RS14865 ENOG4105C4X radical SAM domain protein HZR83_RS14870 ENOG4105ENH Sulfatase HZR83_RS14875 ENOG4105Z68 AraC Family Transcriptional Regulator HZR83_RS14885 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HZR83_RS14890 ENOG4106PIH fimbrial-like protein ydeQ HZR83_RS14895 ENOG4106318 fimbrial-like protein YdeR HZR83_RS14910 ENOG4105EKQ RNA-directed DNA polymerase HZR83_RS14935 ENOG4105CAF HipA N-terminal domain protein HZR83_RS14940 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HZR83_RS14955 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HZR83_RS14960 ENOG4105DKT Transcriptional regulator HZR83_RS14965 ENOG4105C2J ABC transporter HZR83_RS14970 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HZR83_RS14980 ENOG4105D4B ABC, transporter HZR83_RS14985 ENOG41061GT Aldolase HZR83_RS14990 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HZR83_RS14995 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HZR83_RS15000 ENOG4105FFC UPF0187 protein HZR83_RS15015 ENOG4105M0C cytoplasmic protein HZR83_RS15020 ENOG4105CSV Glutaminase HZR83_RS15025 ENOG4105C26 Dehydrogenase HZR83_RS15030 ENOG4105EGI Transcriptional regulator HZR83_RS15050 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HZR83_RS15055 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HZR83_RS15060 ENOG4106DNR multiple antibiotic resistance protein HZR83_RS15070 ENOG4105E5W Transporter HZR83_RS15080 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HZR83_RS15085 ENOG4108YDI single-species biofilm formation on inanimate substrate HZR83_RS15090 ENOG4108WTK competence damage-inducible protein HZR83_RS15095 ENOG4105DGW oligopeptidase A HZR83_RS15100 ENOG4105EMU Dehydrogenase HZR83_RS15105 ENOG4107XBN GntR Family Transcriptional Regulator HZR83_RS15110 ENOG41061EV selenium-binding protein YdfZ HZR83_RS15115 ENOG4105DEI Mannitol dehydrogenase HZR83_RS15125 ENOG4105CPQ Dehydrogenase HZR83_RS15130 ENOG4105CXK mandelate racemase muconate lactonizing HZR83_RS15145 ENOG4108MK9 spermidine N(1)-acetyltransferase HZR83_RS15150 ENOG4105D69 UPF0257 lipoprotein ynfC HZR83_RS15155 ENOG4105KBG Protein of unknown function (DUF1161) HZR83_RS15160 ENOG4107QY8 reductase HZR83_RS15165 ENOG4105C3J Cysteine desulfurase HZR83_RS15170 ENOG4105QAX Iron-sulfur HZR83_RS15175 ENOG4107KGK dmso reductase anchor subunit HZR83_RS15180 ENOG4108NEM leader-binding protein dmsD HZR83_RS15190 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HZR83_RS15195 ENOG4105DAG ROK family HZR83_RS15200 ENOG4106NZI LysR family Transcriptional regulator HZR83_RS15205 ENOG4105D94 Major Facilitator Superfamily HZR83_RS15220 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HZR83_RS15235 ENOG4105DSF transport protein HZR83_RS15240 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HZR83_RS15245 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HZR83_RS15250 ENOG4105C5D exported protein HZR83_RS15255 ENOG4105D5Q Arginine ornithine antiporter HZR83_RS15265 ENOG4105RA2 Membrane HZR83_RS15270 ENOG4107EXC regulatoR HZR83_RS15275 ENOG4105JJR Histidine kinase HZR83_RS15285 ENOG4105C9Q fumarate hydratase class II HZR83_RS15290 ENOG4105VNT transposase (IS4 family) protein HZR83_RS15295 ENOG4107GFK fumarate HZR83_RS15300 ENOG4105EIP mannose-6-phosphate isomerase HZR83_RS15305 ENOG4106J39 exported protein HZR83_RS15310 ENOG4108QNI outer membrane porin protein HZR83_RS15315 ENOG4105CT4 transporter HZR83_RS15320 ENOG4105CNT hydrolase family 2 HZR83_RS15325 ENOG4105XEA Tetr family transcriptional regulator HZR83_RS15330 ENOG4107ZQV short-chain dehydrogenase reductase HZR83_RS15335 ENOG4107P2S Transcriptional regulator HZR83_RS15340 ENOG4105CI1 PTS System HZR83_RS15345 ENOG4105C87 Aminotransferase class I and II HZR83_RS15355 ENOG4105D9R oxidoreductase HZR83_RS15360 ENOG4106C6R beta-lactam resistance protein HZR83_RS15365 ENOG4105QZ5 OriC-binding nucleoid-associated protein HZR83_RS15370 ENOG4105M9B inner membrane protein ydgK HZR83_RS15395 ENOG4108UQQ Electron transport complex HZR83_RS15405 ENOG4105CSM endonuclease III HZR83_RS15410 ENOG4105DUX Transporter HZR83_RS15415 ENOG4108K3A Glutathione S-transferase HZR83_RS15420 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HZR83_RS15435 ENOG410642K Lysozyme inhibitor HZR83_RS15445 ENOG4108XTF Outer Membrane Lipoprotein HZR83_RS15460 ENOG4105Y49 secretion protein, HlyD family HZR83_RS15465 ENOG4105DSW Fusaric acid resistance protein HZR83_RS15470 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HZR83_RS15475 ENOG4107RGM aldo keto reductase HZR83_RS15480 ENOG4105XZD Fe-S protein HZR83_RS15485 ENOG4108WUH Transcriptional regulator, TetR family HZR83_RS15490 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HZR83_RS15495 ENOG4108UYE Lactoylglutathione lyase HZR83_RS15505 ENOG4107QRT dEAD DEAH box helicase HZR83_RS15510 ENOG4105M2J Glutaredoxin HZR83_RS15520 ENOG4105K4H Nlp p60 protein HZR83_RS15525 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HZR83_RS15530 ENOG4105F27 Major Facilitator HZR83_RS15545 ENOG4105F52 Transcriptional regulator HZR83_RS15550 ENOG4105CZQ inner membrane transport protein YdhC HZR83_RS15555 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HZR83_RS15560 ENOG4108R6K riboflavin synthase, subunit alpha HZR83_RS15565 ENOG4107QI1 Mate efflux family protein HZR83_RS15585 ENOG4105N0V mono-oxygenase ydhR HZR83_RS15590 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HZR83_RS15595 ENOG4108Y7C Conserved Protein HZR83_RS15600 ENOG4108NWD Cytochrome HZR83_RS15605 ENOG4108393 oxidoreductase Fe-S subunit HZR83_RS15610 ENOG4105JVW HZR83_RS15615 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HZR83_RS15620 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HZR83_RS15625 ENOG4105RFR Protein of unknown function (DUF2767) HZR83_RS15630 ENOG4105CA9 Pyruvate kinase HZR83_RS15635 ENOG4105KMX major outer membrane lipoprotein HZR83_RS15640 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HZR83_RS15650 ENOG4105C9B Cysteine desulfurase HZR83_RS15655 ENOG4105JRK feS assembly protein SufD HZR83_RS15660 ENOG4105C3K feS assembly ATPase SufC HZR83_RS15665 ENOG4105DIW FeS assembly protein SUFB HZR83_RS15670 ENOG4108Z4V iron-sulfur cluster assembly HZR83_RS15675 ENOG410671Z uncharacterized protein ydiH HZR83_RS15680 ENOG4105KA0 thioesterase Superfamily protein HZR83_RS15685 ENOG4105CQB FAD linked oxidase domain protein HZR83_RS15690 ENOG4105IPI Membrane HZR83_RS15700 ENOG4105SUA Ydil protein HZR83_RS15715 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HZR83_RS15730 ENOG4105EMV Major Facilitator HZR83_RS15745 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HZR83_RS15755 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HZR83_RS15770 ENOG4108TC0 Diguanylate phosphodiesterase HZR83_RS15775 ENOG4108QBX (LipO)protein HZR83_RS15785 ENOG4108V06 Glutathione peroxidase HZR83_RS15820 ENOG41082NX 50s ribosomal protein l35 HZR83_RS15825 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HZR83_RS15845 ENOG4108NE3 Salt-induced outer membrane protein HZR83_RS15850 ENOG4105DE4 1-phosphofructokinase HZR83_RS15855 ENOG4105P10 Uncharacterized protein ydiZ HZR83_RS15865 ENOG4107PN8 YfeABCD locus regulator HZR83_RS15870 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HZR83_RS15875 ENOG4107K5X Membrane-bound metal-dependent hydrolase HZR83_RS15880 ENOG4108ETY sodium dicarboxylate symporter HZR83_RS15900 ENOG4105CH6 catalase HZR83_RS15910 ENOG4105F8D glycoside hydrolase family 4 HZR83_RS15915 ENOG4105EZV Transcriptional regulator HZR83_RS15920 ENOG4105VCP PTS System HZR83_RS15925 ENOG4105CK1 PTS System HZR83_RS15930 ENOG4105VZJ PTS System HZR83_RS15935 ENOG4105KKI DNA-binding transcriptional activator OsmE HZR83_RS15945 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HZR83_RS15955 ENOG4108SPG Periplasmic Protein HZR83_RS15985 ENOG4105CGK Exodeoxyribonuclease III HZR83_RS15990 ENOG4108RSN SNARE associated Golgi HZR83_RS15995 ENOG4108KCW iron-sulfur cluster binding HZR83_RS16000 ENOG4108N5C SNARE associated Golgi protein-related protein HZR83_RS16005 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HZR83_RS16010 ENOG4105VNH ABC transporter solute-binding protein HZR83_RS16015 ENOG4105CXZ ABC transporter, permease HZR83_RS16020 ENOG4108VGW abc transporter atp-binding protein HZR83_RS16025 ENOG4107RM6 sulfurtransferase HZR83_RS16030 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HZR83_RS16035 ENOG4105M6F mutator MutT protein HZR83_RS16040 ENOG4105MTM Protein of unknown function (DUF1496) HZR83_RS16045 ENOG4105D82 Glutamate dehydrogenase HZR83_RS16050 ENOG41065FB inner membrane protein ynji HZR83_RS16055 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HZR83_RS16060 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HZR83_RS16065 ENOG41069NU Nitroreductase HZR83_RS16070 ENOG4105D07 Signal peptide peptidase, SppA HZR83_RS16075 ENOG4105HDK L-asparaginase HZR83_RS16080 ENOG4108RWI nicotinamidase HZR83_RS16085 ENOG4108KUU Inner membrane metabolite transport protein ydjE HZR83_RS16090 ENOG4105E98 transcriptional regulator DeoR family HZR83_RS16095 ENOG4105CPC Aldo Keto reductase HZR83_RS16115 ENOG4105CPQ Dehydrogenase HZR83_RS16120 ENOG4105VUT cytoplasmic protein HZR83_RS16130 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HZR83_RS16135 ENOG4105DSB aldose 1-epimerase HZR83_RS16140 ENOG4105CV8 reductase HZR83_RS16145 ENOG4105GNX MltA-interacting MipA family protein HZR83_RS16150 ENOG4105CYN Serine protein kinase HZR83_RS16160 ENOG4106KTS Inner membrane protein yeaI HZR83_RS16165 ENOG4108KHP Diguanylate cyclase HZR83_RS16170 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HZR83_RS16185 ENOG4105R1U AraC Family Transcriptional Regulator HZR83_RS16195 ENOG4105K78 MarR family Transcriptional regulator HZR83_RS16200 ENOG4105UCG Domain of unknown function (DUF333) HZR83_RS16205 ENOG410620I Diguanylate cyclase HZR83_RS16210 ENOG4106G4W HZR83_RS16220 ENOG4105Y3U Transglycosylase-associated protein HZR83_RS16225 ENOG4105YP6 Domain of unknown function (DUF1869) HZR83_RS16230 ENOG4108YS1 cytoplasmic protein HZR83_RS16240 ENOG4105EJC lysr family transcriptional regulator HZR83_RS16245 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HZR83_RS16255 ENOG4105DVW rieske (2Fe-2S) HZR83_RS16260 ENOG4105E3J oxidoreductase HZR83_RS16265 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HZR83_RS16270 ENOG4105CEY Amp-dependent synthetase and ligase HZR83_RS16275 ENOG4105Y4Z Outer Membrane Lipoprotein HZR83_RS16280 ENOG41072GX Peptidase M22 Glycoprotease HZR83_RS16285 ENOG4105DVT helicase HZR83_RS16290 ENOG4105M4H endoribonuclease L-psp HZR83_RS16295 ENOG4105V2F Uncharacterized protein yoac HZR83_RS16305 ENOG4105CRQ synthase (Component I) HZR83_RS16315 ENOG4105EJQ L-serine dehydratase HZR83_RS16320 ENOG4107XTP (EAL) domain protein HZR83_RS16325 ENOG4105EE5 Membrane protein terC HZR83_RS16330 ENOG4105DAS pts system HZR83_RS16335 ENOG4105ETZ PTS System HZR83_RS16340 ENOG4105F3R pts system mannose fructose sorbose family iid HZR83_RS16355 ENOG4105DHI Methyltransferase HZR83_RS16370 ENOG4105Q3Y exported protein HZR83_RS16380 ENOG4105TIK HZR83_RS16385 ENOG4105J4Q Transcriptional regulator HZR83_RS16390 ENOG4105C0R drug resistance transporter emrb qaca subfamily HZR83_RS16400 ENOG4105CN1 protease HZR83_RS16410 ENOG4108ZGC gaf domain protein HZR83_RS16415 ENOG4105H2K paraquat-inducible protein a HZR83_RS16420 ENOG4105DY2 Paraquat-inducible protein b HZR83_RS16425 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HZR83_RS16430 ENOG4105WT8 Protein of unknown function (DUF1480) HZR83_RS16435 ENOG4105UVW uncharacterized protein yebW HZR83_RS16440 ENOG4108R1E Serine threonine protein phosphatase 1 HZR83_RS16445 ENOG4105NKT exported protein HZR83_RS16450 ENOG4108PNC copper resistance HZR83_RS16455 ENOG4105FXM Copper resistance protein HZR83_RS16460 ENOG4105MPK DNA polymerase III subunit theta HZR83_RS16465 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HZR83_RS16470 ENOG4105UMD exodeoxyribonuclease X HZR83_RS16475 ENOG4105CUG Oligopeptidase b HZR83_RS16480 ENOG4108Q2J Inner membrane protein YebE HZR83_RS16490 ENOG4105X2V dna damage-inducible protein HZR83_RS16495 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HZR83_RS16500 ENOG4108UHU Aldolase HZR83_RS16505 ENOG4105C01 Dihydroxy-acid dehydratase HZR83_RS16510 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HZR83_RS16515 ENOG4106KNT transcriptional regulator HZR83_RS16520 ENOG4105CA9 Pyruvate kinase HZR83_RS16525 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HZR83_RS16530 ENOG4105DR5 peptidase HZR83_RS16535 ENOG4105NXV High-affinity zinc uptake system protein HZR83_RS16545 ENOG4105FAV ABC, transporter HZR83_RS16570 ENOG4107S01 Repressor protein MetJ HZR83_RS16580 ENOG4105CDY transcriptional regulatory protein HZR83_RS16585 ENOG4108TIT dATP pyrophosphohydrolase HZR83_RS16595 ENOG4105D3W isochorismatase HZR83_RS16600 ENOG41081XQ Conserved Protein HZR83_RS16605 ENOG4105WJG Glutathione HZR83_RS16610 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HZR83_RS16620 ENOG4107QY8 reductase HZR83_RS16625 ENOG4105CUW cytochrome C-TYPE protein HZR83_RS16635 ENOG4106ZCM YecM protein HZR83_RS16640 ENOG4105C75 arginyL-tRNA synthetase HZR83_RS16655 ENOG4105W13 flagellar protein HZR83_RS16660 ENOG4105D7B Flagellar biosynthesis protein flha HZR83_RS16665 ENOG4105D00 flagellar biosynthetic protein flhB HZR83_RS16670 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HZR83_RS16675 ENOG4108VYJ response regulator receiver protein HZR83_RS16680 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HZR83_RS16685 ENOG4105BZU Histidine kinase HZR83_RS16690 ENOG4105C8Q Methyl-accepting chemotaxis HZR83_RS16695 ENOG4105C8Q Methyl-accepting chemotaxis HZR83_RS16700 ENOG4108V3W Chemotaxis protein, CheW HZR83_RS16710 ENOG4105ER2 Ompa motb domain protein HZR83_RS16715 ENOG4107RD7 Flagellar Motor Protein, MotA HZR83_RS16720 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HZR83_RS16730 ENOG4108VA4 Universal stress protein HZR83_RS16740 ENOG4108K4C ec 3.1.3.12 HZR83_RS16745 ENOG4105CNN ABC, transporter HZR83_RS16755 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HZR83_RS16760 ENOG4108UEC Ferritin-like protein HZR83_RS16765 ENOG4105N4N Protein of unknown function (DUF2766) HZR83_RS16775 ENOG4105P23 (LipO)protein HZR83_RS16780 ENOG41090A1 ferritin HZR83_RS16785 ENOG4105VVZ metal-binding protein HZR83_RS16790 ENOG4105E0U tyrosine-specific transport protein HZR83_RS16795 ENOG4106RHG Yeca family HZR83_RS16805 ENOG4105EKQ RNA-directed DNA polymerase HZR83_RS16845 ENOG4105DZR Type I site-specific deoxyribonuclease HZR83_RS16855 ENOG4106RHG Yeca family HZR83_RS16860 ENOG4107XZC Restriction modification system DNA (Specificity HZR83_RS16935 ENOG4105WH1 Two component transcriptional regulator luxr family HZR83_RS16945 ENOG4105XVG cytoplasmic protein HZR83_RS16950 ENOG4105VJY transcriptional regulator HZR83_RS16955 ENOG4105CDA abc transporter atp-binding protein HZR83_RS16960 ENOG4105E5Q amino acid AbC transporter HZR83_RS16965 ENOG4105K6H D-cysteine desulfhydrase HZR83_RS16970 ENOG4105EAB amino acid AbC transporter HZR83_RS16975 ENOG4108M9K flagella biosynthesis protein FliZ HZR83_RS16980 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HZR83_RS17005 ENOG4105MQ3 flagellar protein FliS HZR83_RS17010 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HZR83_RS17015 ENOG4105E5K Alpha-amylase HZR83_RS17020 ENOG4108W9D (LipO)protein HZR83_RS17025 ENOG41066VF YeeE YedE family protein HZR83_RS17040 ENOG4105D7V transposase HZR83_RS17055 ENOG410814C multidrug resistance protein HZR83_RS17060 ENOG4108V1U phospholipid-binding protein HZR83_RS17085 ENOG4105YX3 cellular response to acidity HZR83_RS17100 ENOG4105VNZ cytoplasmic protein HZR83_RS17105 ENOG4105CKW Inner membrane protein yedI HZR83_RS17110 ENOG4105FDR Membrane HZR83_RS17115 ENOG41090BB DNA mismatch endonuclease (vsr) HZR83_RS17120 ENOG4105DVF Cytosine-specific methyltransferase HZR83_RS17125 ENOG4105EST Metal Dependent Phosphohydrolase HZR83_RS17135 ENOG4105ZIT Porin Gram-negative type HZR83_RS17145 ENOG4107ZY3 Histidine kinase HZR83_RS17150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HZR83_RS17155 ENOG4105VT2 5-hydroxyisourate hydrolase HZR83_RS17170 ENOG4108MEK Metal-binding protein YodA HZR83_RS17205 ENOG4105FYV Amp nucleosidase HZR83_RS17210 ENOG4105CDY transcriptional regulatory protein HZR83_RS17230 ENOG4107R11 Transcriptional regulator HZR83_RS17235 ENOG4106P55 Transcriptional regulator HZR83_RS17245 ENOG4108PXI ErfK YbiS YcfS YnhG HZR83_RS17250 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HZR83_RS17260 ENOG4108YZT Adenosylcobinamide kinase HZR83_RS17285 ENOG4106H6R UPF0380 protein HZR83_RS17290 ENOG4106549 Antirestriction protein HZR83_RS17295 ENOG4108YGG dna repair protein HZR83_RS17305 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HZR83_RS17340 ENOG4105DR8 Membrane HZR83_RS17350 ENOG4105DZ1 carboxypeptidase HZR83_RS17355 ENOG4105CJB Exodeoxyribonuclease I HZR83_RS17365 ENOG4105CUC YeeE YedE family protein HZR83_RS17370 ENOG4105CUB amino acid HZR83_RS17380 ENOG4105EQ1 Transcriptional regulator HZR83_RS17385 ENOG4107SRH Nad-dependent epimerase dehydratase HZR83_RS17390 ENOG4105KRQ Addiction module toxin, Txe YoeB family HZR83_RS17395 ENOG4105VTW prevent-host-death family HZR83_RS17420 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HZR83_RS17425 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HZR83_RS17440 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HZR83_RS17465 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HZR83_RS17470 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HZR83_RS17480 ENOG4105C1B dTDP-glucose 4-6-dehydratase HZR83_RS17485 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HZR83_RS17525 ENOG4108KBE Glycosyl transferase, family 2 HZR83_RS17530 ENOG4105D3Q Sugar transferase HZR83_RS17545 ENOG4105DAY polysaccharide export protein HZR83_RS17550 ENOG4108MRJ HZR83_RS17570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HZR83_RS17575 ENOG4105EE5 Membrane protein terC HZR83_RS17580 ENOG4108GAE asmA family HZR83_RS17590 ENOG4105DBI uridine monophosphokinase HZR83_RS17595 ENOG4105BZU Histidine kinase HZR83_RS17600 ENOG4105D03 DNA-3-methyladenine glycosylase II HZR83_RS17605 ENOG4105R8A Heat shock protein HZR83_RS17620 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HZR83_RS17625 ENOG4108M24 von Willebrand factor, type A HZR83_RS17650 ENOG4105BZS acriflavin resistance protein HZR83_RS17665 ENOG4105EB3 Histidine kinase HZR83_RS17670 ENOG4105E3W Two component transcriptional regulator (Winged helix family HZR83_RS17675 ENOG4105KWI UPF0339 protein HZR83_RS17680 ENOG4105CFP Peptidase U32 HZR83_RS17685 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HZR83_RS17690 ENOG4105ZTC transcriptional activator, Ogr delta HZR83_RS17730 ENOG4105UZW Tail fiber assembly protein HZR83_RS17735 ENOG410685N tail fiber protein HZR83_RS17825 ENOG4105ED4 portal protein HZR83_RS17885 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HZR83_RS17890 ENOG41076Z6 Uncharacterized protein yegR HZR83_RS17905 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HZR83_RS17910 ENOG4105DT3 PTS system, galactitol-specific IIc component HZR83_RS17915 ENOG41090UW PTS System HZR83_RS17920 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HZR83_RS17935 ENOG4105EIE fructose-bisphosphate aldolase HZR83_RS17940 ENOG4105EAA nucleoside HZR83_RS17945 ENOG4108KD5 ADP-ribosylation crystallin J1 HZR83_RS17950 ENOG4108TFM Kinase, PfkB family HZR83_RS17955 ENOG4105FDP GntR family transcriptional regulator HZR83_RS17960 ENOG4108UQ1 hydrolase, family 25 HZR83_RS17965 ENOG4105DWF phosphomethylpyrimidine kinase HZR83_RS17980 ENOG41061MD high-affinity nickel-transporter HZR83_RS17985 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HZR83_RS17990 ENOG410662B Type-1 fimbrial protein HZR83_RS17995 ENOG4105CW0 outer membrane usher protein HZR83_RS18000 ENOG4108MQF Chaperone HZR83_RS18005 ENOG41063W2 Fimbrial protein HZR83_RS18010 ENOG41067AK Protein of unknown function (DUF2574) HZR83_RS18015 ENOG4105D1F ATP-binding protein HZR83_RS18025 ENOG4108KDT Molybdate metabolism regulator HZR83_RS18030 ENOG4108KDT Molybdate metabolism regulator HZR83_RS18040 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HZR83_RS18045 ENOG4105RD5 HZR83_RS18050 ENOG4105DEG Vwa containing coxe family protein HZR83_RS18055 ENOG410903U zinc ion binding HZR83_RS18060 ENOG4108YCW (LipO)protein HZR83_RS18065 ENOG4108W15 Protein of unknown function (DUF1456) HZR83_RS18070 ENOG4108NEV two component transcriptional regulator, LytTR family HZR83_RS18075 ENOG4108HRK Histidine kinase HZR83_RS18090 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HZR83_RS18095 ENOG4108IJ8 ABC transporter HZR83_RS18100 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HZR83_RS18105 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HZR83_RS18110 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HZR83_RS18115 ENOG4105CXG d-lactate dehydrogenase HZR83_RS18120 ENOG41061WM D-Alanyl-D-Alanine HZR83_RS18125 ENOG41069YE inner membrane protein yohC HZR83_RS18130 ENOG4105KHU inner membrane protein YohD HZR83_RS18135 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HZR83_RS18140 ENOG4105ETP RND efflux system, outer membrane lipoprotein HZR83_RS18150 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HZR83_RS18160 ENOG41067MG lrgb family HZR83_RS18170 ENOG4107GZ4 SanA protein HZR83_RS18175 ENOG4105Y9N Membrane HZR83_RS18180 ENOG4105BZ8 glutamate synthase HZR83_RS18185 ENOG4107SJI Dehydrogenase HZR83_RS18190 ENOG4108HWV )-transporter HZR83_RS18195 ENOG4105C2J ABC transporter HZR83_RS18200 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HZR83_RS18205 ENOG41060NJ transcriptional regulator HZR83_RS18210 ENOG4105DHF Membrane HZR83_RS18225 ENOG4105D05 Receptor HZR83_RS18230 ENOG4108IQI permease HZR83_RS18235 ENOG4105DUM transcriptional regulator, lysR family HZR83_RS18240 ENOG4105HMI Membrane HZR83_RS18265 ENOG4105D9N nucleoside HZR83_RS18275 ENOG4108Y4K DNA-binding transcriptional activator HZR83_RS18280 ENOG4105D9N nucleoside HZR83_RS18285 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HZR83_RS18290 ENOG4105DD7 kinase (PfkB family HZR83_RS18295 ENOG4105DM4 PTS System HZR83_RS18300 ENOG4105DE4 1-phosphofructokinase HZR83_RS18305 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HZR83_RS18310 ENOG4105S8Q sugar efflux transporter HZR83_RS18315 ENOG4105KRS Proteinase inhibitor HZR83_RS18325 ENOG4105DEI Mannitol dehydrogenase HZR83_RS18330 ENOG4105CKI cobalamin synthesis protein HZR83_RS18335 ENOG41076MN Phosphoesterase, PA-phosphatase related HZR83_RS18340 ENOG4107TT5 NLP P60 protein HZR83_RS18345 ENOG4105CXC rtn protein HZR83_RS18350 ENOG4105E43 Extracellular solute-binding protein, family 5 HZR83_RS18355 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HZR83_RS18360 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HZR83_RS18365 ENOG4108JQ5 ABC transporter HZR83_RS18370 ENOG4105HG6 HZR83_RS18375 ENOG4105C2C drug resistance transporter, Bcr CflA HZR83_RS18380 ENOG4105I08 Pseudouridine synthase HZR83_RS18385 ENOG4105CFI type iii restriction protein res subunit HZR83_RS18405 ENOG4105E68 Sulfatase HZR83_RS18420 ENOG4105WH1 Two component transcriptional regulator luxr family HZR83_RS18425 ENOG4105KWW Biogenesis protein HZR83_RS18430 ENOG4107QX9 Thiol disulfide interChange protein HZR83_RS18435 ENOG4105DA4 cytochrome c-type biogenesis protein HZR83_RS18445 ENOG4105X3C heme exporter protein HZR83_RS18450 ENOG41060IM Heme exporter protein HZR83_RS18455 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HZR83_RS18460 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HZR83_RS18465 ENOG4105CUW cytochrome C-TYPE protein HZR83_RS18470 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HZR83_RS18475 ENOG4105GXZ Ferredoxin-type protein NapH HZR83_RS18480 ENOG4108BGM Quinol dehydrogenase periplasmic component HZR83_RS18485 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HZR83_RS18490 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HZR83_RS18495 ENOG4108ZNS ferredoxin-type protein NapF HZR83_RS18510 ENOG4105DWT malate dehydrogenase (quinone) HZR83_RS18515 ENOG4105IBP Cyclic peptide transporter HZR83_RS18520 ENOG4105CF1 Alkylated DNA repair protein HZR83_RS18525 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HZR83_RS18530 ENOG4105CJ2 (LipO)protein HZR83_RS18535 ENOG4105FCK Membrane HZR83_RS18540 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HZR83_RS18545 ENOG41068CG regulatoR HZR83_RS18550 ENOG4105BZU Histidine kinase HZR83_RS18555 ENOG4105BZU Histidine kinase HZR83_RS18560 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HZR83_RS18565 ENOG4107QP7 CoA-transferase subunit A HZR83_RS18570 ENOG4107QNJ CoA-transferase subunit B HZR83_RS18575 ENOG4105CRW Short chain fatty acid transporter HZR83_RS18580 ENOG4105CHU acetyl-coa acetyltransferase HZR83_RS18585 ENOG4105EDV vault protein HZR83_RS18590 ENOG41081SK signal peptide protein HZR83_RS18595 ENOG4107S52 alpha-2-macroglobulin domain protein HZR83_RS18600 ENOG4108QJJ Protein of unknown function (DUF1175) HZR83_RS18605 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HZR83_RS18610 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HZR83_RS18620 ENOG4107GHC outer membrane autotransporter HZR83_RS18625 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HZR83_RS18630 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HZR83_RS18635 ENOG4105XPH Ferredoxin HZR83_RS18640 ENOG4105FQR PH-inducible protein involved in stress response HZR83_RS18645 ENOG4105CZM Major Facilitator HZR83_RS18650 ENOG4105GZI Transcriptional regulator HZR83_RS18655 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HZR83_RS18660 ENOG4105CXY transporter HZR83_RS18665 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HZR83_RS18675 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HZR83_RS18680 ENOG4105DNE Transposase HZR83_RS18695 ENOG4105CSP Major Facilitator Superfamily HZR83_RS18705 ENOG4107258 Transcriptional regulator HZR83_RS18710 ENOG4108EWA cinA-like protein HZR83_RS18715 ENOG4108UII YfaZ family HZR83_RS18765 ENOG4106GZG polymyxin resistance protein B HZR83_RS18770 ENOG4105CEY Amp-dependent synthetase and ligase HZR83_RS18780 ENOG4108IPT Naphthoate synthase HZR83_RS18795 ENOG4105E4F Isochorismate synthase HZR83_RS18800 ENOG4105TNS Conserved Protein HZR83_RS18805 ENOG4107YB6 acetyltransferase, (GNAT) family HZR83_RS18820 ENOG4107VAM peptidase, m28 HZR83_RS18825 ENOG4105GDX Domain of unknown function (DUF1877) HZR83_RS18835 ENOG4105C8S subunit m HZR83_RS18840 ENOG4105D65 subunit l HZR83_RS18850 ENOG4107UFS subunit j HZR83_RS18865 ENOG4108IEH NADH dehydrogenase subunit g HZR83_RS18870 ENOG4107QIZ NADH dehydrogenase HZR83_RS18875 ENOG4105GKE subunit e HZR83_RS18895 ENOG4107NQ8 LysR family Transcriptional regulator HZR83_RS18900 ENOG4105CHM Aminotransferase HZR83_RS18910 ENOG4107QWE )-transporter HZR83_RS18915 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HZR83_RS18920 ENOG4105XWI UPF0304 protein HZR83_RS18930 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HZR83_RS18935 ENOG4105C6K Malic enzyme HZR83_RS18940 ENOG4105CSX c4-dicarboxylate anaerobic carrier HZR83_RS18945 ENOG4105PTV Nudix Hydrolase HZR83_RS18950 ENOG4108RE9 Phosphodiesterase HZR83_RS18955 ENOG4108SHQ Glutathione S-transferase HZR83_RS18960 ENOG4105CYM Glutathione S-transferase HZR83_RS18965 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HZR83_RS18970 ENOG4105ECP epimerase HZR83_RS18975 ENOG4105DNE Transposase HZR83_RS18980 ENOG4108JEH abc transporter atp-binding protein HZR83_RS18985 ENOG4106YG3 ABC transporter HZR83_RS18990 ENOG4105DSP amino acid AbC transporter HZR83_RS18995 ENOG4105E89 ABC transporter HZR83_RS19000 ENOG4105E89 ABC transporter HZR83_RS19005 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HZR83_RS19010 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HZR83_RS19015 ENOG4105E96 Colicin v production protein HZR83_RS19020 ENOG4108S3P Sporulation domain protein HZR83_RS19025 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HZR83_RS19035 ENOG4105DQR SNARE associated Golgi HZR83_RS19045 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HZR83_RS19055 ENOG4106WZ1 flagella biosynthesis regulator HZR83_RS19060 ENOG4105F9N Major Facilitator Superfamily HZR83_RS19065 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HZR83_RS19070 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HZR83_RS19075 ENOG4105MH2 YfcL protein HZR83_RS19080 ENOG4108BPE -transporting atpase HZR83_RS19085 ENOG4105EJ9 Membrane HZR83_RS19095 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HZR83_RS19100 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HZR83_RS19115 ENOG4105US4 fimbrial-like protein yfcP HZR83_RS19120 ENOG4105UGQ Fimbrial HZR83_RS19125 ENOG4105NEV Fimbrial HZR83_RS19130 ENOG4108FZ9 Chaperone HZR83_RS19135 ENOG4106PG1 outer membrane usher protein HZR83_RS19145 ENOG4108BY2 phosphohistidine phosphatase HZR83_RS19160 ENOG4105KZW UPF0381 protein HZR83_RS19165 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HZR83_RS19175 ENOG410903C (LipO)protein HZR83_RS19180 ENOG4105S64 Formate nitrite transporter HZR83_RS19250 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HZR83_RS19255 ENOG4105D7K pfkb domain protein HZR83_RS19260 ENOG4108HKT sucrose-6-phosphate hydrolase HZR83_RS19265 ENOG4106NDP Transcriptional regulator HZR83_RS19280 ENOG4105C0R drug resistance transporter emrb qaca subfamily HZR83_RS19285 ENOG4105CW7 secretion protein, HlyD family HZR83_RS19290 ENOG4108WQH regulatoR HZR83_RS19295 ENOG4105BZU Histidine kinase HZR83_RS19300 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HZR83_RS19305 ENOG4108N2Y auxin Efflux HZR83_RS19310 ENOG4105CFN oxalyl-CoA decarboxylase HZR83_RS19320 ENOG4108V08 YfdX protein HZR83_RS19330 ENOG4105W9M Membrane HZR83_RS19335 ENOG4105D1S lipid A biosynthesis HZR83_RS19345 ENOG4105CHM Aminotransferase HZR83_RS19350 ENOG4108HRK Histidine kinase HZR83_RS19355 ENOG4105DY9 regulatoR HZR83_RS19360 ENOG4108CIP transcriptional regulator HZR83_RS19365 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HZR83_RS19370 ENOG4105CN9 Peptidase m42 family protein HZR83_RS19375 ENOG4105DC7 peptidase M24 HZR83_RS19380 ENOG410863U PTS System HZR83_RS19385 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HZR83_RS19395 ENOG4105VCT ion-transport protein YfeO HZR83_RS19400 ENOG4109076 Conserved Protein HZR83_RS19410 ENOG4105D9N nucleoside HZR83_RS19415 ENOG4108KMM Diguanylate cyclase HZR83_RS19430 ENOG4105HZG regulatoR HZR83_RS19435 ENOG4105GXM Putative transcription regulator (DUF1323) HZR83_RS19470 ENOG4105CN8 Transcriptional regulator HZR83_RS19480 ENOG4105EAA nucleoside HZR83_RS19485 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HZR83_RS19490 ENOG4108NFH Sugar hydrolase HZR83_RS19495 ENOG4108M0I Transcriptional regulator HZR83_RS19500 ENOG4105DHU Bile acid HZR83_RS19505 ENOG4105VRT cytoplasmic protein HZR83_RS19525 ENOG4105C6T cysteine synthase HZR83_RS19535 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HZR83_RS19540 ENOG4105C5Y PTS System HZR83_RS19550 ENOG4105M0Y HZR83_RS19555 ENOG4105C6T cysteine synthase HZR83_RS19560 ENOG4108IJ6 ABC transporter HZR83_RS19565 ENOG4105ECW sulfate abc transporter HZR83_RS19570 ENOG4108I5D sulfate abc transporter HZR83_RS19575 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HZR83_RS19580 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HZR83_RS19595 ENOG4105C5Y PTS System HZR83_RS19600 ENOG4107S1E Beta-lactamase HZR83_RS19605 ENOG4108RS6 transposase HZR83_RS19610 ENOG4105EZR dyp-type peroxidase family protein HZR83_RS19615 ENOG4105E7K (LipO)protein HZR83_RS19620 ENOG4105QZU Inner membrane protein YfeZ HZR83_RS19630 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HZR83_RS19640 ENOG4108K3Z AraC family transcriptional regulator HZR83_RS19645 ENOG4108X49 Ethanolamine utilization protein EutK HZR83_RS19650 ENOG4106D67 ethanolamine utilization protein HZR83_RS19660 ENOG4105CPD ethanolamine ammonia-lyase HZR83_RS19665 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HZR83_RS19670 ENOG4105ENY Ethanolamine utilization protein eutH HZR83_RS19675 ENOG4105C0A alcohol dehydrogenase HZR83_RS19680 ENOG4107RWI ethanolamine utilization protein eutJ HZR83_RS19685 ENOG4108EKI Dehydrogenase HZR83_RS19690 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HZR83_RS19695 ENOG4105KNY Microcompartments protein HZR83_RS19700 ENOG4107WUY phosphate acetyltransferase HZR83_RS19705 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HZR83_RS19710 ENOG4105NDK ethanolamine utilization protein HZR83_RS19715 ENOG4106S4J ethanolamine utilization protein EutP HZR83_RS19720 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HZR83_RS19725 ENOG4105C6K Malic enzyme HZR83_RS19730 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HZR83_RS19735 ENOG4105CV1 Transketolase (EC 2.2.1.1) HZR83_RS19740 ENOG4108PVD exported protein HZR83_RS19750 ENOG4105BZ8 glutamate synthase HZR83_RS19755 ENOG4105BZU Histidine kinase HZR83_RS19760 ENOG4105BZS acriflavin resistance protein HZR83_RS19770 ENOG4105KUZ arsenate reductase HZR83_RS19785 ENOG4106KED esterase YpfH HZR83_RS19795 ENOG4105CGZ zinc metallopeptidase HZR83_RS19805 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HZR83_RS19815 ENOG4105RH4 Glycine cleavage system transcriptional repressor HZR83_RS19820 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HZR83_RS19825 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HZR83_RS19830 ENOG4108JPZ Monovalent cation H antiporter subunit D HZR83_RS19835 ENOG4107TDF Formate hydrogenlyase subunit 4 HZR83_RS19840 ENOG4105D65 subunit l HZR83_RS19845 ENOG4107WQX hydrogenase 4 membrane subunit HZR83_RS19850 ENOG4108JPZ Monovalent cation H antiporter subunit D HZR83_RS19855 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HZR83_RS19865 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HZR83_RS19870 ENOG4105I6X formate hydrogenlyase maturation HZR83_RS19875 ENOG4108JUA Transcriptional regulator HZR83_RS19880 ENOG4105TMB Formate nitrite transporter HZR83_RS19885 ENOG4105C02 permease HZR83_RS19890 ENOG4105ERG peptidase m48, ste24p HZR83_RS19895 ENOG4105K89 arsenate reductase HZR83_RS19900 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HZR83_RS19905 ENOG4105C2W permease HZR83_RS19920 ENOG4108V3E phosphoribosylglycinamide formyltransferase HZR83_RS19925 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HZR83_RS19930 ENOG4105C9X ppx gppa phosphatase HZR83_RS19935 ENOG4105BZU Histidine kinase HZR83_RS19945 ENOG41062G3 Protein of unknown function (DUF2633) HZR83_RS19950 ENOG4108ZMA Outer membrane lipoprotein HZR83_RS19955 ENOG41066DY Membrane HZR83_RS19965 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HZR83_RS19990 ENOG4105VPD cellular component movement HZR83_RS20005 ENOG4105N21 Membrane HZR83_RS20035 ENOG4108JQB penicillin-binding protein 1C HZR83_RS20040 ENOG4105DN3 alpha-2-macroglobulin domain protein HZR83_RS20045 ENOG4105KHC sulfurtransferase HZR83_RS20050 ENOG4105YYA enhanced serine sensitivity protein SseB HZR83_RS20060 ENOG4105WVQ Fe-S assembly protein IscX HZR83_RS20065 ENOG4108ZIT Ferredoxin, 2FE-2S HZR83_RS20085 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HZR83_RS20105 ENOG4105ECY inositol monophosphatase HZR83_RS20110 ENOG4107XM9 (LipO)protein HZR83_RS20115 ENOG4108MN2 Stationary phase inducible protein CsiE HZR83_RS20120 ENOG4105D8G Major Facilitator superfamily HZR83_RS20125 ENOG4108W5M transcriptional regulator HZR83_RS20130 ENOG4105FUY alpha subunit HZR83_RS20155 ENOG4108SB3 DoxX Family HZR83_RS20160 ENOG4108ZKT aldose 1-epimerase HZR83_RS20165 ENOG4105CPQ Dehydrogenase HZR83_RS20170 ENOG4105CNN ABC, transporter HZR83_RS20175 ENOG4108F37 ATP-binding component of a transport system HZR83_RS20180 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HZR83_RS20185 ENOG4107HQ7 repeat protein HZR83_RS20190 ENOG4108NZE NAGC-like transcriptional regulator HZR83_RS20200 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HZR83_RS20210 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HZR83_RS20215 ENOG4108SKK alpha helix protein HZR83_RS20220 ENOG4107WP9 Histidine kinase HZR83_RS20225 ENOG4108ETH Formylglycinamide ribotide synthetase HZR83_RS20235 ENOG4108Z6B deaminase HZR83_RS20240 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HZR83_RS20245 ENOG4106G6Q Transcriptional regulator HZR83_RS20250 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HZR83_RS20265 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HZR83_RS20285 ENOG4105C3F Signal peptidase i HZR83_RS20295 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HZR83_RS20300 ENOG4105VQK sigma E regulatory protein, MucB RseB HZR83_RS20305 ENOG41069PW sigma-e factor negative regulatory protein HZR83_RS20310 ENOG4105EMN RNA polymerase sigma factor HZR83_RS20320 ENOG4108IYU L-aspartate oxidase HZR83_RS20330 ENOG4105C1J atp-dependent rna helicase HZR83_RS20335 ENOG41090KR LysR family transcriptional Regulator HZR83_RS20355 ENOG4105EIB trna rrna methyltransferase HZR83_RS20360 ENOG4105K63 Thioredoxin HZR83_RS20365 ENOG4106IUH DTW domain containing protein HZR83_RS20370 ENOG4105CD5 CoA-binding domain protein HZR83_RS20375 ENOG4105JIM Phosphatidylserine synthase HZR83_RS20380 ENOG4105T42 (LipO)protein HZR83_RS20385 ENOG4105CSH Transporter HZR83_RS20415 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HZR83_RS20420 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HZR83_RS20425 ENOG4105C34 Pseudouridine synthase HZR83_RS20430 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HZR83_RS20435 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HZR83_RS20445 ENOG4105CQC Prephenate dehydratase HZR83_RS20450 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HZR83_RS20455 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HZR83_RS20460 ENOG4105QP9 Protein of unknown function (DUF2799) HZR83_RS20465 ENOG4108WS1 HZR83_RS20470 ENOG4108KHX Diguanylate cyclase HZR83_RS20475 ENOG41090EK ompa motb domain protein HZR83_RS20500 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HZR83_RS20505 ENOG4106KVJ cytochrome C assembly protein HZR83_RS20510 ENOG4108JU6 CBS domain protein HZR83_RS20525 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HZR83_RS20530 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HZR83_RS20540 ENOG4108Z1B Cyclase dehydrase HZR83_RS20555 ENOG4105DFP Integrase HZR83_RS20640 ENOG4105E54 alpha-amylase HZR83_RS20650 ENOG4105D5U fad dependent oxidoreductase HZR83_RS20655 ENOG4105C26 Dehydrogenase HZR83_RS20660 ENOG4108JPW Aminotransferase HZR83_RS20665 ENOG4105C85 amino acid HZR83_RS20670 ENOG4108PVQ transcriptional regulator HZR83_RS20675 ENOG4109066 lysm domain bon superfamily protein HZR83_RS20680 ENOG4105VPI YqaE family transport protein HZR83_RS20685 ENOG41080HT Transcriptional regulator, arsr family HZR83_RS20690 ENOG4108V62 Rhodanese domain protein HZR83_RS20695 ENOG4108X73 DNA- binding protein HZR83_RS20700 ENOG4108RNS Exports L-alanine (By similarity) HZR83_RS20705 ENOG4108WMJ Protein of unknown function (DUF2002) HZR83_RS20715 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HZR83_RS20725 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HZR83_RS20730 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HZR83_RS20735 ENOG4108IJ7 Glycine betaine HZR83_RS20740 ENOG4108HQS Glycine betaine HZR83_RS20745 ENOG4105GIJ Glycine betaine HZR83_RS20755 ENOG4108UMN azlc family HZR83_RS20760 ENOG4105ZED uncharacterized protein ygaH HZR83_RS20765 ENOG4105NTK Transcriptional repressor Mpra HZR83_RS20770 ENOG4105CW7 secretion protein, HlyD family HZR83_RS20775 ENOG4105C0R drug resistance transporter emrb qaca subfamily HZR83_RS20790 ENOG4105W39 Membrane HZR83_RS20795 ENOG4107VXZ Hydrolase HZR83_RS20825 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HZR83_RS20845 ENOG4107TH8 cina domain protein HZR83_RS20850 ENOG4105CVE Lytic murein transglycosylase HZR83_RS20855 ENOG410787A Pts system, glucitol sorbitol-specific HZR83_RS20860 ENOG4105DZY Pts system, glucitol sorbitol-specific HZR83_RS20865 ENOG4105VI0 Pts system, glucitol sorbitol-specific HZR83_RS20870 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HZR83_RS20875 ENOG4105J92 DNA-binding transcriptional activator GutM HZR83_RS20880 ENOG410804X Transcriptional regulator HZR83_RS20905 ENOG4105C8H hydrogenase maturation protein Hypf HZR83_RS20910 ENOG4108RC0 Electron transport protein HZR83_RS20915 ENOG4105DDV Transcriptional regulator (LacI family HZR83_RS20920 ENOG4105C5Y PTS System HZR83_RS20925 ENOG4105CS2 ec 3.2.1.21 HZR83_RS20930 ENOG4108Z3N Transcriptional regulator HZR83_RS20935 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HZR83_RS20940 ENOG4108MG9 hydrogenase 3 maturation protease HZR83_RS20945 ENOG4105I6X formate hydrogenlyase maturation HZR83_RS20950 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HZR83_RS20955 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HZR83_RS20960 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HZR83_RS20965 ENOG4107TDF Formate hydrogenlyase subunit 4 HZR83_RS20970 ENOG4107R30 NADH dehydrogenase HZR83_RS20975 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HZR83_RS20980 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HZR83_RS20985 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HZR83_RS20990 ENOG4107RSS Hydrogenase accessory protein HypB HZR83_RS20995 ENOG41083WG hydrogenase assembly chaperone HZR83_RS21000 ENOG4105CQS hydrogenase expression formation protein HypD HZR83_RS21005 ENOG4105C45 hydrogenase expression formation protein (HypE) HZR83_RS21010 ENOG4108JUA Transcriptional regulator HZR83_RS21020 ENOG4105VXR cytoplasmic protein HZR83_RS21035 ENOG4105MEW serine threonine protein phosphatase HZR83_RS21040 ENOG4105MVE transcriptional regulator HZR83_RS21045 ENOG4105ZXK Dehydrogenase HZR83_RS21050 ENOG4105G63 Type III effector Hrp-dependent HZR83_RS21055 ENOG4105FB2 class II Aldolase HZR83_RS21060 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HZR83_RS21065 ENOG4105C6Z Gluconate HZR83_RS21070 ENOG4105KZM cytoplasmic protein HZR83_RS21075 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HZR83_RS21080 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HZR83_RS21090 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HZR83_RS21095 ENOG4108K5P (LipO)protein HZR83_RS21130 ENOG4105N0Z inner membrane protein ygbE HZR83_RS21150 ENOG4108MXK alkaline phosphatase isozyme conversion HZR83_RS21155 ENOG4105PWE CRISPR-associated protein cas2 HZR83_RS21160 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HZR83_RS21170 ENOG4108VWQ crispr-associated protein HZR83_RS21175 ENOG41060M0 Crispr-associated protein, cse4 family HZR83_RS21185 ENOG4105CYR Crispr-associated protein, cse1 family HZR83_RS21190 ENOG4105DTT CRISPR-associated helicase, cas3 HZR83_RS21195 ENOG4108SER Transposase HZR83_RS21200 ENOG4107635 Hok Gef family protein HZR83_RS21205 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HZR83_RS21220 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HZR83_RS21225 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HZR83_RS21230 ENOG4105WQV ferredoxin-like protein HZR83_RS21235 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HZR83_RS21245 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HZR83_RS21250 ENOG4106IKH Electron transfer flavoprotein HZR83_RS21255 ENOG4105C54 Major Facilitator superfamily HZR83_RS21260 ENOG4107R3A FAD linked oxidase domain protein HZR83_RS21265 ENOG4105CHR reductase HZR83_RS21270 ENOG4108ITV Inner membrane protein yqcE HZR83_RS21275 ENOG4108CWB sugar kinase ygcE HZR83_RS21280 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HZR83_RS21290 ENOG4105HA9 of methanol dehydrogenase type HZR83_RS21305 ENOG4105DXN mazG family HZR83_RS21310 ENOG4105MZG transcriptional modulator of maze toxin, mazf HZR83_RS21315 ENOG4106A2Z transcriptional regulator antitoxin, MazE HZR83_RS21320 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HZR83_RS21330 ENOG4105BZU Histidine kinase HZR83_RS21335 ENOG4105EQX glucarate dehydratase HZR83_RS21340 ENOG4105EQX glucarate dehydratase HZR83_RS21345 ENOG4105DJB Major Facilitator Superfamily HZR83_RS21350 ENOG4105QDK Flavodoxin HZR83_RS21355 ENOG4105DR9 pseudouridine synthase HZR83_RS21360 ENOG4105WP7 tRNA pseudouridine synthase C HZR83_RS21375 ENOG4105EWT decarboxylase family HZR83_RS21380 ENOG4105C44 Serine transporter HZR83_RS21385 ENOG4105EJQ L-serine dehydratase HZR83_RS21395 ENOG4105C0A alcohol dehydrogenase HZR83_RS21400 ENOG4107W7X Aldolase HZR83_RS21410 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HZR83_RS21420 ENOG4105CNN ABC, transporter HZR83_RS21425 ENOG4105C2J ABC transporter HZR83_RS21430 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HZR83_RS21435 ENOG4105CMG Carbohydrate kinase HZR83_RS21445 ENOG4107EDW L-fucose operon activator HZR83_RS21455 ENOG4105M08 Membrane HZR83_RS21460 ENOG4105ETT transcriptional Regulator, LysR family HZR83_RS21465 ENOG4105M5B (LipO)protein HZR83_RS21470 ENOG4105C9B Cysteine desulfurase HZR83_RS21475 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HZR83_RS21480 ENOG4105CUZ uba thif-type nad fad binding protein HZR83_RS21485 ENOG4105CA3 membrane-bound lytic murein transglycosylase HZR83_RS21510 ENOG4105C2X Arabinose 5-phosphate isomerase HZR83_RS21515 ENOG4105C87 Aminotransferase class I and II HZR83_RS21520 ENOG4105CI1 PTS System HZR83_RS21530 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HZR83_RS21535 ENOG4108EKC n-acetylglutamate synthase HZR83_RS21540 ENOG4107QYX exodeoxyribonuclease v alpha HZR83_RS21545 ENOG4107QKA exodeoxyribonuclease V beta HZR83_RS21550 ENOG4107QXK peptidase HZR83_RS21555 ENOG4105DSY exodeoxyribonuclease V, gamma HZR83_RS21560 ENOG4105RVB Prepilin peptidase dependent protein c HZR83_RS21565 ENOG4105SEN Protein of unknown function (DUF2509) HZR83_RS21570 ENOG4105JCS prepilin peptidase dependent protein HZR83_RS21575 ENOG4105IPU prepilin peptidase dependent protein A HZR83_RS21590 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HZR83_RS21605 ENOG4105EE5 Membrane protein terC HZR83_RS21610 ENOG4105SUV lipoprotein YgdR HZR83_RS21615 ENOG4105CPC Aldo Keto reductase HZR83_RS21630 ENOG41060NJ transcriptional regulator HZR83_RS21640 ENOG4105RQF LysR family Transcriptional regulator HZR83_RS21650 ENOG4107QNK )-transporter HZR83_RS21655 ENOG4105CHR reductase HZR83_RS21665 ENOG4105CHU acetyl-coa acetyltransferase HZR83_RS21670 ENOG4108MHD transport protein HZR83_RS21675 ENOG4105ISV protein with bipartite regulator domain HZR83_RS21680 ENOG4108TC1 Transcriptional regulator HZR83_RS21685 ENOG4105FV3 HZR83_RS21710 ENOG4108YAB Invasion protein HZR83_RS21720 ENOG4105K5T PilT protein HZR83_RS21740 ENOG4108RBT type iii secretion HZR83_RS21745 ENOG4106BTR HZR83_RS21750 ENOG4105Y7Q type iii secretion HZR83_RS21755 ENOG4108RC9 Type III secretion system protein HZR83_RS21770 ENOG4108M6W surface presentation of antigens protein SpaS HZR83_RS21775 ENOG4108TN6 type iii secretion HZR83_RS21780 ENOG4105U07 type iii secretion HZR83_RS21785 ENOG41075IY surface presentation of antigens protein SpaP HZR83_RS21790 ENOG4105T85 surface presentation of antigens protein HZR83_RS21805 ENOG4108JIR Flagellum-specific ATP synthase HZR83_RS21810 ENOG4108HR8 type iii secretion HZR83_RS21815 ENOG4108N8R Invasion protein HZR83_RS21825 ENOG41090HZ type iii secretion HZR83_RS21835 ENOG4108T88 HZR83_RS21845 ENOG4108K5P (LipO)protein HZR83_RS21850 ENOG4105C7W Xanthine dehydrogenase HZR83_RS21855 ENOG4108HR6 Dehydrogenase HZR83_RS21860 ENOG4108UTP (2Fe-2S)-binding domain protein HZR83_RS21865 ENOG4108JUB Transcriptional regulator HZR83_RS21870 ENOG4105IW6 Carbamoyltransferase HZR83_RS21875 ENOG4107RCH Diaminopropionate ammonia-lyase HZR83_RS21880 ENOG4107S4Y M20 DapE family protein YgeY HZR83_RS21890 ENOG4105C5B carbamate kinase HZR83_RS21895 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HZR83_RS21900 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HZR83_RS21905 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HZR83_RS21910 ENOG4105BZ8 glutamate synthase HZR83_RS21915 ENOG4107UUR Chlorohydrolase aminohydrolase HZR83_RS21920 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HZR83_RS21925 ENOG4105C7W Xanthine dehydrogenase HZR83_RS21930 ENOG4105C2W permease HZR83_RS21935 ENOG4107QUY Guanine deaminase HZR83_RS21940 ENOG4105C7N Xanthine uracil vitamin C permease HZR83_RS21945 ENOG4108R8B oxidoreductase Fe-S subunit HZR83_RS21950 ENOG4105BZ8 glutamate synthase HZR83_RS21955 ENOG4105C2W permease HZR83_RS21975 ENOG4105CRK lysyL-tRNA synthetase HZR83_RS21985 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HZR83_RS21990 ENOG4105T95 Thiol disulfide interChange protein HZR83_RS21995 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HZR83_RS22000 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HZR83_RS22005 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HZR83_RS22010 ENOG4105Y75 tpr repeat protein HZR83_RS22020 ENOG4108UT2 hemolysin iii HZR83_RS22025 ENOG4105N5Z UPF0267 protein HZR83_RS22030 ENOG4105CS2 ec 3.2.1.21 HZR83_RS22055 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HZR83_RS22060 ENOG4105D0A hydroxylase HZR83_RS22065 ENOG4107RAQ aminopeptidase HZR83_RS22085 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HZR83_RS22095 ENOG4108JQ1 Dehydrogenase HZR83_RS22115 ENOG4105D5P Methylmalonyl-coA mutase HZR83_RS22120 ENOG4105DJT lAO AO transport system ATPase HZR83_RS22125 ENOG4108M7F enoyl-CoA hydratase isomerase HZR83_RS22130 ENOG4105CYC Transferase HZR83_RS22135 ENOG4105DEQ transcriptional regulator HZR83_RS22140 ENOG4105MPN Membrane HZR83_RS22145 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HZR83_RS22150 ENOG4105D64 Mechanosensitive ion channel HZR83_RS22155 ENOG4105D2N Aldolase HZR83_RS22170 ENOG4107Z1W Fructose transport system kinase HZR83_RS22175 ENOG4108R4K DNA-binding, transcriptional regulator HZR83_RS22180 ENOG4108Q8A Fructose-1,6-bisphosphatase HZR83_RS22185 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HZR83_RS22190 ENOG4105CTS PTS system mannitol-specific HZR83_RS22195 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HZR83_RS22200 ENOG4105CV1 Transketolase (EC 2.2.1.1) HZR83_RS22205 ENOG4108K0D peptidase, M48 HZR83_RS22215 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HZR83_RS22235 ENOG4107QNK )-transporter HZR83_RS22245 ENOG4105RWS endonuclease I HZR83_RS22250 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HZR83_RS22255 ENOG4105D7Z glutathione synthase HZR83_RS22270 ENOG4105CZX twitching motility protein HZR83_RS22275 ENOG4105DFA alanine racemase domain protein HZR83_RS22280 ENOG4108VIA integral membrane protein HZR83_RS22290 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HZR83_RS22295 ENOG4105CSA Coproporphyrinogen iii oxidase HZR83_RS22300 ENOG4106MH3 alpha helix chain HZR83_RS22305 ENOG4105HDK L-asparaginase HZR83_RS22310 ENOG4105K33 Periplasmic Protein HZR83_RS22315 ENOG41090ED Protein with unknown function (DUF469) HZR83_RS22325 ENOG4105CEN a g-specific adenine glycosylase HZR83_RS22340 ENOG4105EAA nucleoside HZR83_RS22345 ENOG4105CXN decarboxylase HZR83_RS22350 ENOG4108UQV Membrane HZR83_RS22580 ENOG4105EYM Major Facilitator superfamily HZR83_RS22590 ENOG4105C0W non-ribosomal peptide synthetase HZR83_RS22610 ENOG4105BZ1 (ABC) transporter HZR83_RS22665 ENOG4105UGU tonB-dependent Receptor HZR83_RS22680 ENOG4108KBJ Inner membrane protein YkgB HZR83_RS22705 ENOG4105CXN decarboxylase HZR83_RS22730 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HZR83_RS22770 ENOG4105CDU Replicative dna helicase HZR83_RS22790 ENOG4108BUD transposase HZR83_RS22800 ENOG4107PE3 Mammalian cell entry related domain protein HZR83_RS22805 ENOG4105E3I toluene tolerance HZR83_RS22810 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HZR83_RS22815 ENOG4105VFK BolA family HZR83_RS22825 ENOG4105HVQ Regulatory factor of maltose metabolism HZR83_RS22830 ENOG4105EAH synthase HZR83_RS22845 ENOG4105QYV Membrane HZR83_RS22855 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HZR83_RS22860 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HZR83_RS22865 ENOG4105HBR Rna-binding protein HZR83_RS22875 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HZR83_RS22880 ENOG4105EEI dihydropteroate synthase HZR83_RS22890 ENOG4105NTZ Preprotein translocase subunit SecG HZR83_RS22900 ENOG4105DIJ Phosphoethanolamine transferase HZR83_RS22920 ENOG4105CHV Transcription elongation factor NusA HZR83_RS22960 ENOG4105C1J atp-dependent rna helicase HZR83_RS22965 ENOG4105CIC tryptophan-specific transport protein HZR83_RS22970 ENOG4105DEN Luciferase family HZR83_RS22990 ENOG4108YYD acetyltransferase HZR83_RS23005 ENOG4107R7Y intracellular protease Pfpi family HZR83_RS23010 ENOG4105K4T epimerase HZR83_RS23015 ENOG4107S21 permease HZR83_RS23020 ENOG4105W4M Transport-associated protein HZR83_RS23040 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HZR83_RS23045 ENOG4106HBN Galactosamine-6-phosphate isomerase HZR83_RS23050 ENOG4105F3R pts system mannose fructose sorbose family iid HZR83_RS23055 ENOG4105ETZ PTS System HZR83_RS23060 ENOG4108UZY PTS System HZR83_RS23070 ENOG4105E70 isomerase HZR83_RS23075 ENOG4105CE4 GlcNAc 6-P deacetylase HZR83_RS23080 ENOG4108YTN IIa component HZR83_RS23085 ENOG4105F3R pts system mannose fructose sorbose family iid HZR83_RS23095 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HZR83_RS23105 ENOG4105E98 transcriptional regulator DeoR family HZR83_RS23110 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HZR83_RS23115 ENOG4105ZEG Suppressor protein HZR83_RS23120 ENOG4105CTX dehydratase HZR83_RS23125 ENOG4105DJB Major Facilitator Superfamily HZR83_RS23135 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HZR83_RS23140 ENOG4105BZW Glycerate kinase HZR83_RS23165 ENOG410811B TRANSCRIPTIONal HZR83_RS23170 ENOG4105C7B Threonine dehydratase HZR83_RS23175 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HZR83_RS23180 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HZR83_RS23185 ENOG4105C6N Formate acetyltransferase HZR83_RS23190 ENOG4105KME endoribonuclease L-psp HZR83_RS23195 ENOG4105EJQ L-serine dehydratase HZR83_RS23200 ENOG4105C44 Serine transporter HZR83_RS23210 ENOG4106D80 Uncharacterized protein YhaL HZR83_RS23215 ENOG4108CNN domain protein HZR83_RS23220 ENOG4105CWB LysR family transcriptional Regulator HZR83_RS23225 ENOG4105KAF membrAne HZR83_RS23255 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HZR83_RS23310 ENOG41073YN Protein of unknown function (DUF1380) HZR83_RS23315 ENOG4106JQ7 HZR83_RS23500 ENOG4107QHF type ii secretion system protein e HZR83_RS23515 ENOG4105K5T PilT protein HZR83_RS23675 ENOG4107ENK receptor HZR83_RS23705 ENOG4108YXQ IS66 Orf2 family protein HZR83_RS23710 ENOG4108BUD transposase HZR83_RS23720 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HZR83_RS23760 ENOG4108ZHR arsR family transcriptional regulator HZR83_RS23775 ENOG4108BUD transposase HZR83_RS23800 ENOG4108BUD transposase HZR83_RS23840 ENOG4108BUD transposase HZR83_RS23865 ENOG4108BUD transposase HZR83_RS23875 ENOG4105I1F Resistance protein HZR83_RS23885 ENOG4108BUD transposase HZR83_RS23905 ENOG4108BUD transposase HZR83_RS23940 ENOG4106CQM replication HZR83_RS23950 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HZR83_RS23955 ENOG4105EQR Transposase IS116 IS110 IS902 HZR83_RS23980 ENOG4108YXQ IS66 Orf2 family protein HZR83_RS24000 ENOG4105CSX c4-dicarboxylate anaerobic carrier HZR83_RS24005 ENOG4105DBV ornithine carbamoyltransferase HZR83_RS24010 ENOG4105C5B carbamate kinase HZR83_RS24015 ENOG4105CEU Arginine dihydrolase HZR83_RS24055 ENOG4105E5H Transposase HZR83_RS24060 ENOG4108YXQ IS66 Orf2 family protein HZR83_RS24080 ENOG4107CBI conjugal transfer fertility inhibition protein HZR83_RS24270 ENOG41074AV Hok/gef family HZR83_RS24355 ENOG4106JQ7 HZR83_RS24360 ENOG41073YN Protein of unknown function (DUF1380) HZR83_RS24420 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HZR83_RS24425 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HZR83_RS24445 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HZR83_RS24450 ENOG4105DUU IucA IucC family protein HZR83_RS24470 ENOG41082CG Protein CrcB homolog HZR83_RS24485 ENOG4105CC5 ABC transporter HZR83_RS24490 ENOG4105CC5 ABC transporter HZR83_RS24495 ENOG4105DIK (ABC) transporter HZR83_RS24525 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HZR83_RS24530 ENOG4108X73 DNA- binding protein HZR83_RS24585 ENOG4105F2I Transposase HZR83_RS24605 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HZR83_RS24610 ENOG4105EPC oxidoreductase HZR83_RS24615 ENOG4105VF7 tolerance protein HZR83_RS24620 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HZR83_RS24640 ENOG4108BUD transposase HZR83_RS24645 ENOG4108J4B Beta-lactamase HZR83_RS24650 ENOG4105MVE transcriptional regulator HZR83_RS24660 ENOG4108BUD transposase HZR83_RS24680 ENOG4107QJE Chromosome Partitioning Protein HZR83_RS24725 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HZR83_RS24840 ENOG4108EHY type IV secretion system HZR83_RS24865 ENOG4105KK6 nuclease HZR83_RS24870 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)