locus-tag	class	description
HZR83_RS00020	COG0435	Glutathione S-transferase
HZR83_RS00025	COG2259	Doxx family
HZR83_RS00035	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HZR83_RS00040	COG4575	ribosome binding
HZR83_RS00045	COG1422	Protein of unknown function (DUF1090)
HZR83_RS00055	COG0586	Pfam SNARE associated Golgi protein
HZR83_RS00060	COG2186	Transcriptional regulator
HZR83_RS00065	COG2271	Major facilitator Superfamily
HZR83_RS00075	COG2721	sulfolactate sulfo-lyase activity
HZR83_RS00085	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HZR83_RS00090	COG0861	Integral membrane protein TerC family
HZR83_RS00095	COG0673	inositol 2-dehydrogenase activity
HZR83_RS00100	COG2949	membrane
HZR83_RS00105	COG1451	nucleotide metabolic process
HZR83_RS00115	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZR83_RS00115	COG1902	pentaerythritol trinitrate reductase activity
HZR83_RS00120	COG3408	Glycogen debranching enzyme
HZR83_RS00120	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HZR83_RS00130	COG0531	amino acid
HZR83_RS00135	COG2731	YhcH YjgK YiaL family protein
HZR83_RS00140	COG3250	beta-galactosidase activity
HZR83_RS00145	COG1609	Transcriptional regulator
HZR83_RS00150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZR83_RS00160	COG0840	transmembrane signaling receptor activity
HZR83_RS00165	COG1695	Transcriptional regulator
HZR83_RS00170	COG2375	cellular response to nickel ion
HZR83_RS00200	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZR83_RS00280	COG3344	reverse transcriptase
HZR83_RS00295	COG1620	l-lactate permease
HZR83_RS00300	COG0277	FAD linked oxidase domain protein
HZR83_RS00305	COG0247	lactate metabolic process
HZR83_RS00310	COG1139	Iron-sulfur cluster binding protein
HZR83_RS00315	COG1556	Lactate utilization protein
HZR83_RS00325	COG3039	Transposase
HZR83_RS00335	COG0732	type I restriction modification DNA specificity domain
HZR83_RS00350	COG3468	outer membrane autotransporter barrel domain protein
HZR83_RS00365	COG2003	Belongs to the UPF0758 family
HZR83_RS00410	COG3385	transposase activity
HZR83_RS00415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZR83_RS00420	COG0358	DNA primase activity
HZR83_RS00425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HZR83_RS00440	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HZR83_RS00445	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HZR83_RS00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZR83_RS00475	COG4991	sh3 domain protein
HZR83_RS00480	COG3025	triphosphatase activity
HZR83_RS00505	COG2268	Band 7 protein
HZR83_RS00510	COG1585	Membrane protein implicated in regulation of membrane protease activity
HZR83_RS00520	COG3539	Fimbrial protein
HZR83_RS00525	COG3121	Chaperone
HZR83_RS00530	COG3188	usher protein
HZR83_RS00535	COG3539	Fimbrial protein
HZR83_RS00540	COG2960	long-chain fatty acid transporting porin activity
HZR83_RS00560	COG3384	dioxygenase
HZR83_RS00565	COG0754	glutathionylspermidine amidase activity
HZR83_RS00575	COG1538	Outer membrane efflux protein
HZR83_RS00580	COG0494	nUDIX hydrolase
HZR83_RS00585	COG3151	Protein conserved in bacteria
HZR83_RS00590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HZR83_RS00595	COG3150	esterase
HZR83_RS00600	COG0187	DNA topoisomerase II activity
HZR83_RS00605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HZR83_RS00610	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZR83_RS00620	COG0642	Histidine kinase
HZR83_RS00625	COG0745	RESPONSE REGULATOR receiver
HZR83_RS00630	COG3111	PFAM Bacterial OB fold (BOF) protein
HZR83_RS00635	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HZR83_RS00645	COG2944	sequence-specific DNA binding
HZR83_RS00650	COG4166	transmembrane transport
HZR83_RS00655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZR83_RS00660	COG0204	Acyl-transferase
HZR83_RS00665	COG2132	Multicopper oxidase
HZR83_RS00670	COG1032	radical SAM domain protein
HZR83_RS00675	COG4238	major outer membrane lipoprotein
HZR83_RS00685	COG0656	L-ascorbic acid biosynthetic process
HZR83_RS00690	COG1979	alcohol dehydrogenase
HZR83_RS00695	COG2207	Transcriptional regulator
HZR83_RS00700	COG0586	Pfam SNARE associated Golgi protein
HZR83_RS00705	COG0626	cystathionine gamma-synthase activity
HZR83_RS00710	COG0811	peptide transport
HZR83_RS00715	COG0848	biopolymer transport protein
HZR83_RS00720	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS00730	COG0667	Aldo Keto reductase
HZR83_RS00745	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HZR83_RS00750	COG0437	4 iron, 4 sulfur cluster binding
HZR83_RS00755	COG5557	Pfam Polysulphide reductase, NrfD
HZR83_RS00760	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HZR83_RS00765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZR83_RS00770	COG1773	rubredoxin
HZR83_RS00780	COG0298	carbon dioxide binding
HZR83_RS00785	COG0625	glutathione transferase activity
HZR83_RS00790	COG0754	glutathionylspermidine amidase activity
HZR83_RS00795	COG0306	phosphate transporter
HZR83_RS00800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZR83_RS00805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZR83_RS00810	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZR83_RS00830	COG1127	ABC transporter
HZR83_RS00835	COG0530	calcium, potassium:sodium antiporter activity
HZR83_RS00840	COG0517	IMP dehydrogenase activity
HZR83_RS00840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HZR83_RS00845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HZR83_RS00850	COG3117	lipopolysaccharide transmembrane transporter activity
HZR83_RS00855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HZR83_RS00860	COG1137	ATPase activity
HZR83_RS00865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HZR83_RS00870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HZR83_RS00885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS00890	COG0515	serine threonine protein kinase
HZR83_RS00900	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HZR83_RS00905	COG5002	protein histidine kinase activity
HZR83_RS00905	COG2198	Histidine kinase
HZR83_RS00905	COG0784	Response regulator, receiver
HZR83_RS00910	COG1242	4 iron, 4 sulfur cluster binding
HZR83_RS00915	COG0069	glutamate synthase activity
HZR83_RS00915	COG0070	glutamate synthase
HZR83_RS00915	COG0067	glutamate synthase
HZR83_RS00920	COG0493	'glutamate synthase
HZR83_RS00925	COG3539	Fimbrial protein
HZR83_RS00930	COG3121	Chaperone
HZR83_RS00935	COG3188	usher protein
HZR83_RS00945	COG3539	Fimbrial protein
HZR83_RS00960	COG4804	nuclease activity
HZR83_RS00965	COG2731	YhcH YjgK YiaL family protein
HZR83_RS00995	COG3069	C4-dicarboxylate transmembrane transporter activity
HZR83_RS01000	COG2969	positive regulation of protein catabolic process
HZR83_RS01005	COG0625	glutathione transferase activity
HZR83_RS01020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HZR83_RS01025	COG3105	Protein conserved in bacteria
HZR83_RS01030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZR83_RS01035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZR83_RS01055	COG2732	(Barnase) inhibitor
HZR83_RS01075	COG0583	DNA-binding transcription factor activity
HZR83_RS01080	COG0312	modulator of DNA gyrase
HZR83_RS01085	COG3164	Protein of unknown function
HZR83_RS01090	COG1530	ribonuclease E activity
HZR83_RS01095	COG0424	maF-like protein
HZR83_RS01100	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HZR83_RS01105	COG1792	Involved in formation and maintenance of cell shape
HZR83_RS01110	COG1077	Cell shape determining protein MreB Mrl
HZR83_RS01115	COG2199	diguanylate cyclase activity
HZR83_RS01115	COG2200	EAL domain
HZR83_RS01120	COG0604	alcohol dehydrogenase
HZR83_RS01125	COG0511	ligase activity, forming carbon-carbon bonds
HZR83_RS01130	COG0439	Biotin carboxylase
HZR83_RS01135	COG3924	membrane
HZR83_RS01140	COG4145	pantothenate transmembrane transporter activity
HZR83_RS01150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZR83_RS01160	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HZR83_RS01170	COG1309	transcriptional regulator
HZR83_RS01190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZR83_RS01200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZR83_RS01205	COG4597	amino acid ABC transporter
HZR83_RS01210	COG0765	amino acid transport
HZR83_RS01215	COG1126	abc transporter atp-binding protein
HZR83_RS01255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZR83_RS01275	COG0551	DNA topoisomerase type I activity
HZR83_RS01285	COG0758	DNA mediated transformation
HZR83_RS01305	COG0569	domain protein
HZR83_RS01315	COG3036	rescue of stalled ribosome
HZR83_RS01320	COG0789	Transcriptional regulator
HZR83_RS01360	COG0201	protein transport
HZR83_RS01450	COG0089	rRNA binding
HZR83_RS01475	COG3267	Type II secretory pathway component ExeA
HZR83_RS01475	COG3409	Peptidoglycan-binding domain 1 protein
HZR83_RS01480	COG3031	protein transport across the cell outer membrane
HZR83_RS01485	COG1450	Type ii and iii secretion system protein
HZR83_RS01490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZR83_RS01495	COG1459	type II secretion system
HZR83_RS01500	COG2165	general secretion pathway protein
HZR83_RS01505	COG2165	general secretion pathway protein
HZR83_RS01510	COG2165	general secretion pathway protein
HZR83_RS01515	COG4795	General secretion pathway protein
HZR83_RS01520	COG3156	type II secretion system protein K
HZR83_RS01525	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HZR83_RS01530	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HZR83_RS01535	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HZR83_RS01540	COG2193	ferroxidase activity
HZR83_RS01545	COG2906	2 iron, 2 sulfur cluster binding
HZR83_RS01600	COG2964	Protein conserved in bacteria
HZR83_RS01605	COG0545	Peptidyl-prolyl cis-trans isomerase
HZR83_RS01615	COG1047	Peptidyl-prolyl cis-trans
HZR83_RS01620	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HZR83_RS01635	COG0488	(ABC) transporter
HZR83_RS01640	COG0429	hydrolase of the alpha beta-hydrolase fold
HZR83_RS01650	COG3954	Phosphoribulokinase
HZR83_RS01655	COG1765	OsmC-like protein
HZR83_RS01660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZR83_RS01665	COG1289	transmembrane transporter activity
HZR83_RS01670	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZR83_RS01675	COG0512	Glutamine amidotransferase of anthranilate synthase
HZR83_RS01680	COG2184	nucleotidyltransferase activity
HZR83_RS01690	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZR83_RS01700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZR83_RS01705	COG2146	nitrite reductase [NAD(P)H] activity
HZR83_RS01710	COG2116	formate transmembrane transporter activity
HZR83_RS01725	COG0531	amino acid
HZR83_RS01730	COG2222	sugar isomerase
HZR83_RS01735	COG1082	Xylose isomerase domain protein TIM barrel
HZR83_RS01740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZR83_RS01745	COG2188	Transcriptional regulator
HZR83_RS01750	COG0626	cystathionine gamma-synthase activity
HZR83_RS01765	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HZR83_RS01770	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HZR83_RS01775	COG3457	Alanine racemase
HZR83_RS01785	COG2188	Transcriptional regulator
HZR83_RS01790	COG0180	Tryptophanyl-tRNA synthetase
HZR83_RS01795	COG0546	phosphoglycolate phosphatase activity
HZR83_RS01800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZR83_RS01805	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HZR83_RS01810	COG3266	domain, Protein
HZR83_RS01825	COG4796	Type ii and iii secretion system protein
HZR83_RS01840	COG3166	PFAM Fimbrial assembly family protein
HZR83_RS01845	COG4972	Pilus assembly protein
HZR83_RS01850	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HZR83_RS01855	COG0494	nUDIX hydrolase
HZR83_RS01865	COG1011	Hydrolase
HZR83_RS01870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HZR83_RS01880	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HZR83_RS01890	COG2205	protein histidine kinase activity
HZR83_RS01895	COG0745	RESPONSE REGULATOR receiver
HZR83_RS01900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZR83_RS01905	COG2183	response to ionizing radiation
HZR83_RS01910	COG1918	ferrous iron import across plasma membrane
HZR83_RS01915	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HZR83_RS01925	COG5464	transposase or invertase
HZR83_RS01935	COG1040	competence protein
HZR83_RS01945	COG2610	gluconate transmembrane transporter activity
HZR83_RS01950	COG1640	4-alpha-glucanotransferase
HZR83_RS01955	COG0058	SHG alpha-glucan phosphorylase activity
HZR83_RS01970	COG1690	Belongs to the RtcB family
HZR83_RS01975	COG4650	regulator
HZR83_RS01980	COG1349	DNA-binding transcription factor activity
HZR83_RS01995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZR83_RS02005	COG0058	SHG alpha-glucan phosphorylase activity
HZR83_RS02030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZR83_RS02035	COG2095	MarC family integral membrane protein
HZR83_RS02040	COG2610	gluconate transmembrane transporter activity
HZR83_RS02045	COG3265	gluconokinase activity
HZR83_RS02050	COG1609	Transcriptional regulator
HZR83_RS02055	COG1741	Belongs to the pirin family
HZR83_RS02060	COG0673	inositol 2-dehydrogenase activity
HZR83_RS02065	COG1247	-acetyltransferase
HZR83_RS02070	COG3157	Type VI secretion system effector, Hcp
HZR83_RS02090	COG0405	Gamma-glutamyltransferase
HZR83_RS02100	COG0584	glycerophosphoryl diester phosphodiesterase
HZR83_RS02105	COG3842	ATPase activity
HZR83_RS02110	COG0395	ABC-type sugar transport system, permease component
HZR83_RS02115	COG1175	transmembrane transport
HZR83_RS02120	COG1653	transport
HZR83_RS02125	COG0410	ABC transporter
HZR83_RS02130	COG0411	ABC transporter
HZR83_RS02135	COG4177	L-phenylalanine transmembrane transporter activity
HZR83_RS02140	COG0559	Belongs to the binding-protein-dependent transport system permease family
HZR83_RS02145	COG0683	leucine binding
HZR83_RS02150	COG0456	acetyltransferase
HZR83_RS02155	COG0683	leucine binding
HZR83_RS02160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZR83_RS02165	COG2177	Part of the ABC transporter FtsEX involved in
HZR83_RS02170	COG2884	Cell division ATP-binding protein ftsE
HZR83_RS02175	COG0552	protein localization to endoplasmic reticulum
HZR83_RS02180	COG0742	ribosomal rna small subunit methyltransferase
HZR83_RS02185	COG3776	membrane
HZR83_RS02195	COG3714	YhhN family
HZR83_RS02200	COG2217	Heavy metal translocating P-type atpase
HZR83_RS02210	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HZR83_RS02220	COG0477	Major facilitator Superfamily
HZR83_RS02225	COG0628	permease
HZR83_RS02230	COG2091	lysine biosynthetic process via aminoadipic acid
HZR83_RS02235	COG0747	negative chemotaxis
HZR83_RS02240	COG0601	transmembrane transport
HZR83_RS02245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZR83_RS02250	COG0444	Belongs to the ABC transporter superfamily
HZR83_RS02255	COG1124	(ABC) transporter
HZR83_RS02265	COG3209	COG3209 Rhs family protein
HZR83_RS02275	COG1413	lyase activity
HZR83_RS02280	COG5433	transposase activity
HZR83_RS02285	COG0842	Transport permease protein
HZR83_RS02290	COG1129	ABC transporter
HZR83_RS02290	COG0842	Transport permease protein
HZR83_RS02295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZR83_RS02350	COG1196	nuclear chromosome segregation
HZR83_RS02355	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HZR83_RS02385	COG2081	HI0933 family
HZR83_RS02390	COG0306	phosphate transporter
HZR83_RS02400	COG0589	response to stress
HZR83_RS02405	COG3104	oligopeptide transport
HZR83_RS02415	COG0339	signal peptide processing
HZR83_RS02420	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HZR83_RS02425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZR83_RS02435	COG0640	Transcriptional regulator
HZR83_RS02440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZR83_RS02445	COG1393	Belongs to the ArsC family
HZR83_RS02455	COG3065	identical protein binding
HZR83_RS02460	COG2197	response regulator
HZR83_RS02465	COG1285	pathogenesis
HZR83_RS02480	COG3247	response to pH
HZR83_RS02485	COG2771	luxR family
HZR83_RS02495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZR83_RS02500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZR83_RS02505	COG2207	Transcriptional regulator
HZR83_RS02510	COG2207	Transcriptional regulator
HZR83_RS02515	COG0076	glutamate decarboxylase activity
HZR83_RS02520	COG1858	cytochrome C peroxidase
HZR83_RS02530	COG2197	response regulator
HZR83_RS02535	COG0583	DNA-binding transcription factor activity
HZR83_RS02540	COG1295	ribonuclease BN
HZR83_RS02545	COG0477	Major facilitator Superfamily
HZR83_RS02550	COG2982	Protein involved in outer membrane biogenesis
HZR83_RS02555	COG2200	EAL domain
HZR83_RS02560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZR83_RS02565	COG0612	Peptidase, M16
HZR83_RS02575	COG2199	diguanylate cyclase activity
HZR83_RS02575	COG2200	EAL domain
HZR83_RS02580	COG0457	Tetratricopeptide repeat
HZR83_RS02580	COG3118	belongs to the thioredoxin family
HZR83_RS02590	COG1215	transferase activity, transferring glycosyl groups
HZR83_RS02595	COG1215	transferase activity, transferring glycosyl groups
HZR83_RS02620	COG2194	sulfuric ester hydrolase activity
HZR83_RS02630	COG0814	amino acid
HZR83_RS02635	COG4608	Belongs to the ABC transporter superfamily
HZR83_RS02640	COG0444	Belongs to the ABC transporter superfamily
HZR83_RS02645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZR83_RS02650	COG0601	transmembrane transport
HZR83_RS02660	COG0747	negative chemotaxis
HZR83_RS02675	COG2194	sulfuric ester hydrolase activity
HZR83_RS02680	COG2223	nitrite transmembrane transporter activity
HZR83_RS02685	COG5571	outer membrane autotransporter
HZR83_RS02690	COG2818	Glycosylase
HZR83_RS02695	COG0456	acetyltransferase
HZR83_RS02700	COG0243	molybdopterin cofactor binding
HZR83_RS02705	COG2885	chlorophyll binding
HZR83_RS02720	COG2944	sequence-specific DNA binding
HZR83_RS02725	COG1278	Cold shock
HZR83_RS02755	COG3274	enterobacterial common antigen metabolic process
HZR83_RS02760	COG4682	membrane
HZR83_RS02765	COG4682	membrane
HZR83_RS02770	COG1070	Carbohydrate kinase
HZR83_RS02780	COG4213	ABC transporter substrate-binding protein
HZR83_RS02785	COG1129	ABC transporter
HZR83_RS02790	COG4214	carbohydrate transport
HZR83_RS02795	COG1609	Transcriptional regulator
HZR83_RS02795	COG2207	Transcriptional regulator
HZR83_RS02800	COG2992	FlgJ-related protein
HZR83_RS02805	COG0366	Alpha amylase catalytic
HZR83_RS02810	COG3977	Valine--pyruvate aminotransferase
HZR83_RS02815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZR83_RS02820	COG1414	Transcriptional regulator
HZR83_RS02830	COG2731	YhcH YjgK YiaL family protein
HZR83_RS02835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HZR83_RS02840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HZR83_RS02845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HZR83_RS02850	COG1070	Carbohydrate kinase
HZR83_RS02855	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HZR83_RS02860	COG3623	hexulose-6-phosphate isomerase
HZR83_RS02865	COG0235	Class ii aldolase
HZR83_RS02875	COG3713	MltA-interacting MipA family protein
HZR83_RS02880	COG0583	DNA-binding transcription factor activity
HZR83_RS02885	COG1566	PFAM secretion protein HlyD family protein
HZR83_RS02900	COG1012	belongs to the aldehyde dehydrogenase family
HZR83_RS02905	COG1454	alcohol dehydrogenase
HZR83_RS02910	COG3276	selenocysteine insertion sequence binding
HZR83_RS02920	COG0625	glutathione transferase activity
HZR83_RS02925	COG3209	COG3209 Rhs family protein
HZR83_RS02930	COG1413	lyase activity
HZR83_RS02940	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HZR83_RS02950	COG1566	PFAM secretion protein HlyD family protein
HZR83_RS02960	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS02960	COG2213	PTS system mannitol-specific
HZR83_RS02970	COG3722	fumarate hydratase activity
HZR83_RS02985	COG1620	l-lactate permease
HZR83_RS02990	COG2186	Transcriptional regulator
HZR83_RS03000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HZR83_RS03005	COG1045	serine acetyltransferase
HZR83_RS03020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HZR83_RS03025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZR83_RS03035	COG4942	peptidase
HZR83_RS03040	COG2861	carbohydrate metabolic process
HZR83_RS03045	COG1216	Glycosyl transferase, family 2
HZR83_RS03055	COG0156	8-amino-7-oxononanoate synthase activity
HZR83_RS03065	COG0859	PFAM glycosyl transferase family 9
HZR83_RS03070	COG0859	PFAM glycosyl transferase family 9
HZR83_RS03090	COG3642	lipopolysaccharide core region biosynthetic process
HZR83_RS03095	COG1442	glycosyl transferase family 8
HZR83_RS03100	COG1442	glycosyl transferase family 8
HZR83_RS03105	COG0438	transferase activity, transferring glycosyl groups
HZR83_RS03110	COG1442	glycosyl transferase family 8
HZR83_RS03115	COG0515	serine threonine protein kinase
HZR83_RS03120	COG0438	transferase activity, transferring glycosyl groups
HZR83_RS03125	COG0859	PFAM glycosyl transferase family 9
HZR83_RS03130	COG1519	Transferase
HZR83_RS03160	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZR83_RS03185	COG1561	YicC-like family, N-terminal region
HZR83_RS03195	COG3645	SOS response
HZR83_RS03200	COG2860	membrane
HZR83_RS03210	COG0194	GDP metabolic process
HZR83_RS03220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZR83_RS03225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZR83_RS03230	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZR83_RS03235	COG0786	glutamate:sodium symporter activity
HZR83_RS03240	COG2233	PERMEase
HZR83_RS03245	COG2982	Protein involved in outer membrane biogenesis
HZR83_RS03250	COG1501	Belongs to the glycosyl hydrolase 31 family
HZR83_RS03255	COG2211	Major facilitator Superfamily
HZR83_RS03265	COG2814	Major facilitator Superfamily
HZR83_RS03270	COG0697	spore germination
HZR83_RS03275	COG1464	Belongs to the NlpA lipoprotein family
HZR83_RS03295	COG2252	PERMEase
HZR83_RS03305	COG2271	Major facilitator Superfamily
HZR83_RS03310	COG2271	Major facilitator Superfamily
HZR83_RS03315	COG3851	Histidine kinase
HZR83_RS03320	COG2197	response regulator
HZR83_RS03325	COG0440	acetolactate synthase activity
HZR83_RS03330	COG0028	Belongs to the TPP enzyme family
HZR83_RS03350	COG2814	Major facilitator Superfamily
HZR83_RS03355	COG0641	radical SAM
HZR83_RS03365	COG2149	membrane
HZR83_RS03375	COG3119	arylsulfatase activity
HZR83_RS03380	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZR83_RS03385	COG2207	Transcriptional regulator
HZR83_RS03400	COG2188	Transcriptional regulator
HZR83_RS03420	COG5645	(Lipo)protein
HZR83_RS03425	COG0823	Involved in the tonB-independent uptake of proteins
HZR83_RS03430	COG0644	oxidoreductase
HZR83_RS03435	COG2271	Major facilitator Superfamily
HZR83_RS03445	COG0800	Aldolase
HZR83_RS03450	COG3734	2-keto-3-deoxy-galactonokinase
HZR83_RS03455	COG2186	Transcriptional regulator
HZR83_RS03465	COG0561	phosphatase activity
HZR83_RS03470	COG3753	Protein conserved in bacteria
HZR83_RS03475	COG0187	DNA topoisomerase II activity
HZR83_RS03485	COG0592	DNA-directed DNA polymerase activity
HZR83_RS03535	COG0814	amino acid
HZR83_RS03550	COG2091	lysine biosynthetic process via aminoadipic acid
HZR83_RS03555	COG0431	NADPH-dependent FMN reductase
HZR83_RS03560	COG2252	PERMEase
HZR83_RS03565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZR83_RS03580	COG4372	Transposase
HZR83_RS03585	COG3436	PFAM IS66 Orf2 family protein
HZR83_RS03600	COG0363	glucosamine-6-phosphate deaminase activity
HZR83_RS03605	COG2382	esterase
HZR83_RS03615	COG2723	6-phospho-beta-galactosidase activity
HZR83_RS03620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS03620	COG1263	PTS System
HZR83_RS03620	COG2190	(PTS) system
HZR83_RS03625	COG3711	transcriptional antiterminator
HZR83_RS03630	COG0704	Plays a role in the regulation of phosphate uptake
HZR83_RS03635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HZR83_RS03640	COG0581	inorganic phosphate transmembrane transporter activity
HZR83_RS03645	COG0573	inorganic phosphate transmembrane transporter activity
HZR83_RS03650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HZR83_RS03655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZR83_RS03705	COG3312	ion transport
HZR83_RS03720	COG0716	FMN binding
HZR83_RS03725	COG1522	sequence-specific DNA binding
HZR83_RS03755	COG1129	ABC transporter
HZR83_RS03760	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZR83_RS03765	COG1879	ABC-type sugar transport system periplasmic component
HZR83_RS03770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZR83_RS03775	COG1609	Transcriptional regulator
HZR83_RS03780	COG0477	Major facilitator Superfamily
HZR83_RS03785	COG2186	Transcriptional regulator
HZR83_RS03825	COG3085	chromosome segregation
HZR83_RS03830	COG0606	chelatase, subunit chli
HZR83_RS03850	COG3978	acetolactate synthase activity
HZR83_RS03855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZR83_RS03865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZR83_RS03870	COG0583	DNA-binding transcription factor activity
HZR83_RS03880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZR83_RS03890	COG0210	DNA helicase
HZR83_RS03905	COG3118	belongs to the thioredoxin family
HZR83_RS03915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZR83_RS03920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZR83_RS03925	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HZR83_RS03930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HZR83_RS03935	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HZR83_RS03940	COG1088	dTDP-glucose 4,6-dehydratase activity
HZR83_RS03945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HZR83_RS03950	COG0456	acetyltransferase
HZR83_RS03955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZR83_RS03960	COG2244	polysaccharide biosynthetic process
HZR83_RS03980	COG1113	amino acid transport
HZR83_RS04005	COG0641	radical SAM
HZR83_RS04010	COG3119	arylsulfatase activity
HZR83_RS04015	COG3071	HemY protein
HZR83_RS04020	COG2959	enzyme of heme biosynthesis
HZR83_RS04025	COG1587	Uroporphyrinogen-III synthase
HZR83_RS04035	COG3072	Adenylate cyclase
HZR83_RS04045	COG5567	small periplasmic lipoprotein
HZR83_RS04055	COG3159	Protein conserved in bacteria
HZR83_RS04065	COG1011	Hydrolase
HZR83_RS04070	COG0210	DNA helicase
HZR83_RS04075	COG3698	Phosphodiester glycosidase
HZR83_RS04080	COG0598	Magnesium transport protein CorA
HZR83_RS04095	COG2962	Rard protein
HZR83_RS04100	COG2050	protein possibly involved in aromatic compounds catabolism
HZR83_RS04105	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HZR83_RS04110	COG0514	ATP-dependent DNA helicase (RecQ)
HZR83_RS04115	COG1280	lysine exporter protein (LysE YggA)
HZR83_RS04120	COG1280	lysine exporter protein (LysE YggA)
HZR83_RS04125	COG2267	carboxylic ester hydrolase activity
HZR83_RS04130	COG0561	phosphatase activity
HZR83_RS04135	COG0697	spore germination
HZR83_RS04140	COG0583	DNA-binding transcription factor activity
HZR83_RS04150	COG0412	Dienelactone hydrolase
HZR83_RS04155	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HZR83_RS04160	COG1322	Protein conserved in bacteria
HZR83_RS04170	COG3165	ubiquinone biosynthetic process from chorismate
HZR83_RS04180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZR83_RS04185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZR83_RS04190	COG0805	protein transport
HZR83_RS04195	COG0084	hydrolase, TatD family'
HZR83_RS04200	COG0250	Participates in transcription elongation, termination and antitermination
HZR83_RS04205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HZR83_RS04210	COG0543	2 iron, 2 sulfur cluster binding
HZR83_RS04215	COG0183	Belongs to the thiolase family
HZR83_RS04230	COG1739	Uncharacterized protein family UPF0029
HZR83_RS04235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZR83_RS04240	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HZR83_RS04270	COG1763	Mo-molybdopterin cofactor biosynthetic process
HZR83_RS04275	COG0746	molybdenum cofactor guanylyltransferase activity
HZR83_RS04280	COG3084	Protein conserved in bacteria
HZR83_RS04285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HZR83_RS04290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZR83_RS04295	COG5339	Protein conserved in bacteria
HZR83_RS04300	COG0204	Acyl-transferase
HZR83_RS04305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZR83_RS04305	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZR83_RS04320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZR83_RS04330	COG2204	response regulator
HZR83_RS04335	COG3852	Histidine kinase
HZR83_RS04340	COG0174	glutamine synthetase
HZR83_RS04350	COG2188	Transcriptional regulator
HZR83_RS04355	COG1082	Xylose isomerase domain protein TIM barrel
HZR83_RS04360	COG2271	Major facilitator Superfamily
HZR83_RS04365	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HZR83_RS04370	COG2211	Major facilitator Superfamily
HZR83_RS04375	COG2211	Major facilitator Superfamily
HZR83_RS04380	COG1501	Belongs to the glycosyl hydrolase 31 family
HZR83_RS04385	COG2017	converts alpha-aldose to the beta-anomer
HZR83_RS04390	COG2942	2-epimerase
HZR83_RS04395	COG3684	Belongs to the aldolase LacD family
HZR83_RS04400	COG2084	Dehydrogenase
HZR83_RS04405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZR83_RS04410	COG1349	DNA-binding transcription factor activity
HZR83_RS04415	COG1011	Hydrolase
HZR83_RS04430	COG0456	acetyltransferase
HZR83_RS04435	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HZR83_RS04440	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HZR83_RS04450	COG2864	formate dehydrogenase
HZR83_RS04455	COG0437	4 iron, 4 sulfur cluster binding
HZR83_RS04475	COG3711	transcriptional antiterminator
HZR83_RS04475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS04480	COG1363	Peptidase, m42
HZR83_RS04485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS04485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS04490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS04530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZR83_RS04540	COG2258	MOSC domain
HZR83_RS04545	COG2205	protein histidine kinase activity
HZR83_RS04550	COG0745	RESPONSE REGULATOR receiver
HZR83_RS04555	COG3678	ATP-independent chaperone mediated protein folding
HZR83_RS04560	COG4974	Belongs to the 'phage' integrase family
HZR83_RS04625	COG4695	Portal protein
HZR83_RS04730	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HZR83_RS04785	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HZR83_RS04805	COG3152	Membrane
HZR83_RS04810	COG3691	Protein conserved in bacteria
HZR83_RS04815	COG0589	response to stress
HZR83_RS04820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZR83_RS04825	COG1494	fructose-1,6-bisphosphatase
HZR83_RS04835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZR83_RS04850	COG1575	Belongs to the MenA family. Type 1 subfamily
HZR83_RS04865	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZR83_RS04870	COG1609	Transcriptional regulator
HZR83_RS04875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZR83_RS04885	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HZR83_RS04895	COG0626	cystathionine gamma-synthase activity
HZR83_RS04900	COG0527	aspartate kinase activity
HZR83_RS04900	COG0460	homoserine dehydrogenase
HZR83_RS04905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZR83_RS04915	COG0697	spore germination
HZR83_RS04920	COG3738	Protein conserved in bacteria
HZR83_RS04925	COG0371	Dehydrogenase
HZR83_RS04930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZR83_RS04935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZR83_RS04935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS04935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS04940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS04945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS04950	COG1882	Formate acetyltransferase
HZR83_RS04955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZR83_RS04960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS04965	COG2207	Transcriptional regulator
HZR83_RS04970	COG2194	sulfuric ester hydrolase activity
HZR83_RS04985	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZR83_RS05000	COG0583	DNA-binding transcription factor activity
HZR83_RS05010	COG1309	transcriptional regulator
HZR83_RS05025	COG4206	TonB-dependent receptor
HZR83_RS05055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZR83_RS05060	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HZR83_RS05060	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HZR83_RS05095	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZR83_RS05100	COG0250	Participates in transcription elongation, termination and antitermination
HZR83_RS05140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZR83_RS05150	COG2104	thiamine diphosphate biosynthetic process
HZR83_RS05155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZR83_RS05190	COG3068	Protein conserved in bacteria
HZR83_RS05205	COG3678	ATP-independent chaperone mediated protein folding
HZR83_RS05210	COG4191	Histidine kinase
HZR83_RS05215	COG2204	response regulator
HZR83_RS05220	COG0151	Belongs to the GarS family
HZR83_RS05255	COG0456	acetyltransferase
HZR83_RS05265	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HZR83_RS05270	COG2224	Isocitrate lyase
HZR83_RS05285	COG1414	Transcriptional regulator
HZR83_RS05290	COG1410	methionine synthase
HZR83_RS05290	COG0646	methionine synthase
HZR83_RS05295	COG1283	sodium-dependent phosphate transmembrane transporter activity
HZR83_RS05305	COG1187	pseudouridine synthase activity
HZR83_RS05315	COG0527	aspartate kinase activity
HZR83_RS05340	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZR83_RS05375	COG3833	ABC-type maltose transport systems, permease component
HZR83_RS05380	COG1175	transmembrane transport
HZR83_RS05385	COG2182	Extracellular solute-binding protein
HZR83_RS05390	COG3842	ATPase activity
HZR83_RS05425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HZR83_RS05435	COG0534	Mate efflux family protein
HZR83_RS05440	COG3237	CsbD-like
HZR83_RS05445	COG0735	belongs to the Fur family
HZR83_RS05455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZR83_RS05465	COG0604	alcohol dehydrogenase
HZR83_RS05470	COG0305	Participates in initiation and elongation during chromosome replication
HZR83_RS05475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZR83_RS05480	COG1448	Aminotransferase
HZR83_RS05490	COG3700	Belongs to the class B bacterial acid phosphatase family
HZR83_RS05495	COG0432	Pfam Uncharacterised protein family UPF0047
HZR83_RS05500	COG2315	Protein conserved in bacteria
HZR83_RS05505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZR83_RS05510	COG0629	single-stranded DNA binding
HZR83_RS05520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HZR83_RS05525	COG2207	Transcriptional regulator
HZR83_RS05530	COG0789	Transcriptional regulator
HZR83_RS05535	COG2252	PERMEase
HZR83_RS05540	COG0025	NhaP-type Na H and K H
HZR83_RS05545	COG1357	PFAM Pentapeptide repeats (8 copies)
HZR83_RS05555	COG3162	membrane
HZR83_RS05560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZR83_RS05570	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HZR83_RS05575	COG0437	4 iron, 4 sulfur cluster binding
HZR83_RS05580	COG3301	Polysulphide reductase, NrfD
HZR83_RS05585	COG1138	Cytochrome C-type biogenesis protein
HZR83_RS05590	COG3088	subunit of a heme lyase
HZR83_RS05595	COG4235	cytochrome complex assembly
HZR83_RS05600	COG1301	dicarboxylic acid transport
HZR83_RS05605	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HZR83_RS05615	COG1538	Outer membrane efflux protein
HZR83_RS05620	COG1289	transmembrane transporter activity
HZR83_RS05625	COG1566	PFAM secretion protein HlyD family protein
HZR83_RS05635	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HZR83_RS05640	COG1940	carbohydrate kinase activity
HZR83_RS05645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZR83_RS05650	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZR83_RS05655	COG1129	ABC transporter
HZR83_RS05660	COG1879	ABC-type sugar transport system periplasmic component
HZR83_RS05665	COG1737	Transcriptional regulator
HZR83_RS05670	COG0698	ribose 5-phosphate isomerase
HZR83_RS05680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZR83_RS05685	COG0456	acetyltransferase
HZR83_RS05690	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HZR83_RS05695	COG3454	Phosphonate metabolism
HZR83_RS05700	COG4778	phosphonate C-P lyase system protein PhnL
HZR83_RS05705	COG4107	phosphonate C-P lyase system protein PhnK
HZR83_RS05710	COG3627	carbon phosphorus lyase activity
HZR83_RS05715	COG3626	phosphonate metabolism
HZR83_RS05720	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HZR83_RS05725	COG3624	Phosphonate C-P lyase system protein PhnG
HZR83_RS05730	COG2188	Transcriptional regulator
HZR83_RS05740	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HZR83_RS05745	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HZR83_RS05750	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HZR83_RS05755	COG2824	Alkylphosphonate utilization operon protein PhnA
HZR83_RS05770	COG0477	Major facilitator Superfamily
HZR83_RS05780	COG0642	Histidine kinase
HZR83_RS05785	COG0745	RESPONSE REGULATOR receiver
HZR83_RS05790	COG2194	sulfuric ester hydrolase activity
HZR83_RS05795	COG0531	amino acid
HZR83_RS05800	COG2207	Transcriptional regulator
HZR83_RS05805	COG1982	Orn Lys Arg decarboxylase major
HZR83_RS05810	COG2169	Transcriptional regulator
HZR83_RS05815	COG1486	melibiose metabolic process
HZR83_RS05820	COG2211	Major facilitator Superfamily
HZR83_RS05825	COG3647	Membrane
HZR83_RS05830	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HZR83_RS05830	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HZR83_RS05835	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HZR83_RS05840	COG4565	transcriptional regulatory protein
HZR83_RS05845	COG3290	protein histidine kinase activity
HZR83_RS05850	COG3592	Divergent 4Fe-4S mono-cluster
HZR83_RS05855	COG2388	GCN5-related N-acetyl-transferase
HZR83_RS05870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZR83_RS05875	COG3104	oligopeptide transport
HZR83_RS05880	COG1982	Orn Lys Arg decarboxylase major
HZR83_RS05885	COG0531	amino acid
HZR83_RS05890	COG3710	Transcriptional regulator
HZR83_RS05900	COG1309	transcriptional regulator
HZR83_RS05905	COG4232	protein-disulfide reductase activity
HZR83_RS05915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HZR83_RS05920	COG1027	Aspartate ammonia-lyase
HZR83_RS05925	COG3030	protein affecting phage T7 exclusion by the F plasmid
HZR83_RS05930	COG0531	amino acid
HZR83_RS05965	COG1509	lysine 2,3-aminomutase activity
HZR83_RS05975	COG5510	response to toxic substance
HZR83_RS05980	COG5510	response to toxic substance
HZR83_RS05985	COG2076	Multidrug Resistance protein
HZR83_RS05990	COG3040	lipid binding
HZR83_RS05995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZR83_RS06010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZR83_RS06015	COG1053	succinate dehydrogenase
HZR83_RS06025	COG0531	amino acid
HZR83_RS06040	COG3264	Mechanosensitive ion channel
HZR83_RS06040	COG1511	domain protein
HZR83_RS06080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZR83_RS06085	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZR83_RS06085	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZR83_RS06090	COG0802	atpase or kinase
HZR83_RS06095	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZR83_RS06115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZR83_RS06120	COG0330	HflC and HflK could
HZR83_RS06125	COG0330	HflC and HflK could
HZR83_RS06130	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HZR83_RS06145	COG0557	exoribonuclease II activity
HZR83_RS06150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZR83_RS06155	COG1414	Transcriptional regulator
HZR83_RS06160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZR83_RS06165	COG2271	Major facilitator Superfamily
HZR83_RS06170	COG2721	sulfolactate sulfo-lyase activity
HZR83_RS06195	COG3766	membrane
HZR83_RS06200	COG5463	Belongs to the UPF0441 family
HZR83_RS06205	COG0754	glutathionylspermidine amidase activity
HZR83_RS06210	COG1960	acyl-CoA dehydrogenase activity
HZR83_RS06220	COG3650	response to hydrogen peroxide
HZR83_RS06225	COG1073	alpha beta
HZR83_RS06245	COG3414	Phosphotransferase system galactitol-specific IIB component
HZR83_RS06250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS06265	COG0235	Class ii aldolase
HZR83_RS06270	COG3477	response to acidic pH
HZR83_RS06290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZR83_RS06310	COG0675	Transposase, IS605 OrfB family
HZR83_RS06320	COG3061	Opacity-associated protein A
HZR83_RS06325	COG0545	Peptidyl-prolyl cis-trans isomerase
HZR83_RS06330	COG1113	amino acid transport
HZR83_RS06340	COG0697	spore germination
HZR83_RS06345	COG0702	epimerase
HZR83_RS06350	COG1733	regulation of RNA biosynthetic process
HZR83_RS06355	COG0737	Belongs to the 5'-nucleotidase family
HZR83_RS06360	COG1218	3'(2'),5'-bisphosphate nucleotidase
HZR83_RS06370	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HZR83_RS06380	COG1253	flavin adenine dinucleotide binding
HZR83_RS06390	COG0729	surface antigen
HZR83_RS06395	COG2911	Protein conserved in bacteria
HZR83_RS06400	COG2105	PFAM AIG2 family protein
HZR83_RS06405	COG2336	PFAM SpoVT AbrB
HZR83_RS06410	COG2337	Toxic component of a toxin-antitoxin (TA) module
HZR83_RS06415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HZR83_RS06420	COG1879	ABC-type sugar transport system periplasmic component
HZR83_RS06425	COG1129	ABC transporter
HZR83_RS06430	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZR83_RS06435	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZR83_RS06445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZR83_RS06455	COG0312	modulator of DNA gyrase
HZR83_RS06460	COG3783	Cytochrome b(562)
HZR83_RS06465	COG0602	queuosine metabolic process
HZR83_RS06470	COG1328	CTP reductase activity
HZR83_RS06475	COG0366	Alpha amylase catalytic
HZR83_RS06480	COG1263	PTS System
HZR83_RS06480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS06485	COG1609	Transcriptional regulator
HZR83_RS06495	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HZR83_RS06500	COG0251	oxidation-reduction process
HZR83_RS06520	COG0251	oxidation-reduction process
HZR83_RS06525	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS06530	COG1309	transcriptional regulator
HZR83_RS06535	COG2731	YhcH YjgK YiaL family protein
HZR83_RS06550	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HZR83_RS06555	COG0456	acetyltransferase
HZR83_RS06580	COG2927	DNA polymerase III (CHI subunit)
HZR83_RS06590	COG0795	lipopolysaccharide-transporting ATPase activity
HZR83_RS06595	COG0795	lipopolysaccharide-transporting ATPase activity
HZR83_RS06600	COG0433	COG0433 Predicted ATPase
HZR83_RS06605	COG1064	alcohol dehydrogenase
HZR83_RS06615	COG0582	viral genome integration into host DNA
HZR83_RS06700	COG1309	transcriptional regulator
HZR83_RS06715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HZR83_RS06740	COG0726	polysaccharide deacetylase
HZR83_RS06750	COG3344	reverse transcriptase
HZR83_RS06760	COG2085	NADP oxidoreductase coenzyme F420-dependent
HZR83_RS06765	COG1120	ATPase activity
HZR83_RS06770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZR83_RS06775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZR83_RS06780	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HZR83_RS06785	COG4772	TonB-dependent receptor
HZR83_RS06790	COG3712	iron ion homeostasis
HZR83_RS06795	COG1595	DNA-templated transcription, initiation
HZR83_RS06830	COG4372	Transposase
HZR83_RS06835	COG3436	PFAM IS66 Orf2 family protein
HZR83_RS06870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HZR83_RS06885	COG2610	gluconate transmembrane transporter activity
HZR83_RS06895	COG0246	Mannitol dehydrogenase
HZR83_RS06900	COG2186	Transcriptional regulator
HZR83_RS06920	COG0583	DNA-binding transcription factor activity
HZR83_RS06925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZR83_RS06930	COG0700	Nucleoside recognition
HZR83_RS06935	COG3366	ferrous iron transmembrane transporter activity
HZR83_RS06945	COG0477	Major facilitator Superfamily
HZR83_RS06960	COG1924	4 iron, 4 sulfur cluster binding
HZR83_RS06965	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HZR83_RS06970	COG2733	membrane
HZR83_RS06975	COG2814	Major facilitator Superfamily
HZR83_RS06995	COG0523	cobalamin synthesis protein
HZR83_RS07000	COG2879	small protein
HZR83_RS07005	COG1966	Carbon starvation protein
HZR83_RS07010	COG0840	transmembrane signaling receptor activity
HZR83_RS07015	COG2271	Major facilitator Superfamily
HZR83_RS07020	COG1802	Transcriptional regulator
HZR83_RS07025	COG1063	alcohol dehydrogenase
HZR83_RS07040	COG1484	DNA-dependent DNA replication
HZR83_RS07055	COG2966	Psort location CytoplasmicMembrane, score
HZR83_RS07060	COG2197	response regulator
HZR83_RS07065	COG2197	response regulator
HZR83_RS07070	COG4114	ferric iron reductase
HZR83_RS07100	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HZR83_RS07105	COG0456	acetyltransferase
HZR83_RS07110	COG1011	Hydrolase
HZR83_RS07120	COG2823	Periplasmic or secreted lipoprotein
HZR83_RS07130	COG4667	esterase of the alpha-beta hydrolase superfamily
HZR83_RS07135	COG0084	hydrolase, TatD family'
HZR83_RS07140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZR83_RS07145	COG1328	CTP reductase activity
HZR83_RS07180	COG3726	membrane protein affecting hemolysin expression
HZR83_RS07185	COG0560	Phosphoserine phosphatase
HZR83_RS07190	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HZR83_RS07195	COG1056	cytidyltransferase-related domain
HZR83_RS07195	COG3172	ATPase kinase involved in NAD metabolism
HZR83_RS07205	COG0488	(ABC) transporter
HZR83_RS07210	COG0741	lytic transglycosylase activity
HZR83_RS07230	COG2207	Transcriptional regulator
HZR83_RS07230	COG3708	Transcriptional regulator
HZR83_RS07235	COG3045	CreA protein
HZR83_RS07240	COG0745	RESPONSE REGULATOR receiver
HZR83_RS07245	COG2205	protein histidine kinase activity
HZR83_RS07250	COG4452	Inner membrane protein CreD
HZR83_RS07255	COG0745	RESPONSE REGULATOR receiver
HZR83_RS07265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HZR83_RS07275	COG0527	aspartate kinase activity
HZR83_RS07275	COG0460	homoserine dehydrogenase
HZR83_RS07285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HZR83_RS07300	COG1115	amino acid carrier protein
HZR83_RS07305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZR83_RS07310	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZR83_RS07315	COG1584	GPR1 FUN34 yaaH family protein
HZR83_RS07320	COG4735	regulation of single-species biofilm formation
HZR83_RS07340	COG3385	transposase activity
HZR83_RS07360	COG0583	DNA-binding transcription factor activity
HZR83_RS07390	COG0196	riboflavin kinase activity
HZR83_RS07405	COG1047	Peptidyl-prolyl cis-trans
HZR83_RS07425	COG0505	Belongs to the CarA family
HZR83_RS07430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZR83_RS07480	COG0644	oxidoreductase
HZR83_RS07485	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HZR83_RS07490	COG2271	Major facilitator Superfamily
HZR83_RS07505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZR83_RS07530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZR83_RS07535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HZR83_RS07540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HZR83_RS07560	COG0564	pseudouridine synthase activity
HZR83_RS07570	COG0417	DNA replication proofreading
HZR83_RS07575	COG0235	Class ii aldolase
HZR83_RS07580	COG2160	L-arabinose isomerase activity
HZR83_RS07585	COG1069	ribulokinase activity
HZR83_RS07590	COG4977	sequence-specific DNA binding
HZR83_RS07595	COG0586	Pfam SNARE associated Golgi protein
HZR83_RS07600	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HZR83_RS07605	COG1178	ABC-type Fe3 transport system permease component
HZR83_RS07610	COG4143	(ABC) transporter
HZR83_RS07615	COG4533	DNA binding
HZR83_RS07625	COG2814	Major facilitator Superfamily
HZR83_RS07640	COG0473	3-isopropylmalate dehydrogenase activity
HZR83_RS07655	COG0583	DNA-binding transcription factor activity
HZR83_RS07665	COG0028	Belongs to the TPP enzyme family
HZR83_RS07670	COG0440	acetolactate synthase activity
HZR83_RS07680	COG1609	Transcriptional regulator
HZR83_RS07695	COG3116	cell division
HZR83_RS07700	COG0768	penicillin binding
HZR83_RS07705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZR83_RS07710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZR83_RS07725	COG0772	Belongs to the SEDS family
HZR83_RS07740	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZR83_RS07745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HZR83_RS07750	COG0849	cell division
HZR83_RS07755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZR83_RS07775	COG0494	nUDIX hydrolase
HZR83_RS07790	COG0237	dephospho-CoA kinase activity
HZR83_RS07805	COG1459	type II secretion system
HZR83_RS07810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZR83_RS07815	COG4969	Belongs to the N-Me-Phe pilin family
HZR83_RS07820	COG0157	Belongs to the NadC ModD family
HZR83_RS07825	COG3023	N-Acetylmuramoyl-L-alanine amidase
HZR83_RS07830	COG3725	Membrane protein required for beta-lactamase induction
HZR83_RS07835	COG1113	amino acid transport
HZR83_RS07840	COG2186	Transcriptional regulator
HZR83_RS07845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HZR83_RS07850	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZR83_RS07855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZR83_RS07860	COG3064	Membrane
HZR83_RS07865	COG1049	propionate catabolic process, 2-methylcitrate cycle
HZR83_RS07890	COG2132	Multicopper oxidase
HZR83_RS07895	COG4993	Dehydrogenase
HZR83_RS07900	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HZR83_RS07905	COG0288	reversible hydration of carbon dioxide
HZR83_RS07910	COG1131	(ABC) transporter
HZR83_RS07915	COG0842	Transport permease protein
HZR83_RS07920	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS07925	COG0726	polysaccharide deacetylase
HZR83_RS07935	COG5464	transposase or invertase
HZR83_RS07950	COG3539	Fimbrial protein
HZR83_RS07955	COG3539	Fimbrial protein
HZR83_RS07960	COG3539	Fimbrial protein
HZR83_RS07965	COG3539	Fimbrial protein
HZR83_RS07970	COG3188	usher protein
HZR83_RS07975	COG3121	Chaperone
HZR83_RS07980	COG3539	Fimbrial protein
HZR83_RS07985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZR83_RS07990	COG0617	tRNA 3'-terminal CCA addition
HZR83_RS08000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZR83_RS08010	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HZR83_RS08015	COG1643	Atp-dependent helicase
HZR83_RS08020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HZR83_RS08025	COG4774	siderophore transport
HZR83_RS08030	COG1120	ATPase activity
HZR83_RS08035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZR83_RS08040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZR83_RS08065	COG2860	membrane
HZR83_RS08070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZR83_RS08085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZR83_RS08090	COG3835	regulator
HZR83_RS08100	COG1408	metallophosphoesterase
HZR83_RS08115	COG0024	Methionine aminopeptidase
HZR83_RS08140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZR83_RS08145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZR83_RS08150	COG0575	Belongs to the CDS family
HZR83_RS08155	COG0750	zinc metalloprotease
HZR83_RS08165	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HZR83_RS08170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZR83_RS08195	COG0587	DNA-directed DNA polymerase activity
HZR83_RS08210	COG0346	lactoylglutathione lyase activity
HZR83_RS08215	COG0037	tRNA processing
HZR83_RS08220	COG4568	rho-dependent transcription termination
HZR83_RS08230	COG4681	YaeQ
HZR83_RS08235	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HZR83_RS08240	COG3015	lipoprotein NlpE involved in copper resistance
HZR83_RS08245	COG0791	NLP P60 protein
HZR83_RS08255	COG1720	tRNA m6t6A37 methyltransferase activity
HZR83_RS08265	COG1464	Belongs to the NlpA lipoprotein family
HZR83_RS08270	COG2011	ABC-type metal ion transport system permease component
HZR83_RS08275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZR83_RS08280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZR83_RS08315	COG0656	L-ascorbic acid biosynthetic process
HZR83_RS08320	COG0583	DNA-binding transcription factor activity
HZR83_RS08335	COG1388	LysM domain
HZR83_RS08335	COG0741	lytic transglycosylase activity
HZR83_RS08345	COG2226	methyltransferase
HZR83_RS08355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZR83_RS08375	COG4104	PAAR repeat-containing protein
HZR83_RS08380	COG3157	Type VI secretion system effector, Hcp
HZR83_RS08470	COG3501	Rhs element vgr protein
HZR83_RS08475	COG3209	COG3209 Rhs family protein
HZR83_RS08485	COG5433	transposase activity
HZR83_RS08490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZR83_RS08500	COG1960	acyl-CoA dehydrogenase activity
HZR83_RS08510	COG0121	glutamine amidotransferase
HZR83_RS08515	COG3034	peptidoglycan biosynthetic process
HZR83_RS08520	COG3041	Addiction module toxin RelE StbE family
HZR83_RS08525	COG3077	Addiction module antitoxin, RelB DinJ family
HZR83_RS08530	COG0791	NLP P60 protein
HZR83_RS08535	COG1943	Transposase
HZR83_RS08555	COG2161	toxin-antitoxin pair type II binding
HZR83_RS08565	COG0454	-acetyltransferase
HZR83_RS08580	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZR83_RS08600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HZR83_RS08620	COG0582	viral genome integration into host DNA
HZR83_RS08735	COG0583	DNA-binding transcription factor activity
HZR83_RS08740	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZR83_RS08745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZR83_RS08750	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZR83_RS08755	COG2080	2 iron, 2 sulfur cluster binding
HZR83_RS08760	COG3477	response to acidic pH
HZR83_RS08765	COG0727	PFAM Uncharacterised protein family (UPF0153)
HZR83_RS08770	COG3121	Chaperone
HZR83_RS08780	COG3188	usher protein
HZR83_RS08820	COG1388	LysM domain
HZR83_RS08825	COG3708	Transcriptional regulator
HZR83_RS08825	COG2207	Transcriptional regulator
HZR83_RS08835	COG3059	membrane
HZR83_RS08845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZR83_RS08850	COG2207	Transcriptional regulator
HZR83_RS08855	COG0247	lactate metabolic process
HZR83_RS08860	COG1139	Iron-sulfur cluster binding protein
HZR83_RS08865	COG1556	Lactate utilization protein
HZR83_RS08890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HZR83_RS08900	COG2771	luxR family
HZR83_RS08900	COG2200	EAL domain
HZR83_RS08905	COG0583	DNA-binding transcription factor activity
HZR83_RS08915	COG0666	response to abiotic stimulus
HZR83_RS08925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZR83_RS08930	COG1304	FMN binding
HZR83_RS08940	COG0549	Belongs to the carbamate kinase family
HZR83_RS08945	COG0402	S-adenosylhomocysteine deaminase activity
HZR83_RS08950	COG1064	alcohol dehydrogenase
HZR83_RS08965	COG1280	lysine exporter protein (LysE YggA)
HZR83_RS08975	COG3829	transcription factor binding
HZR83_RS08980	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HZR83_RS08985	COG0372	Belongs to the citrate synthase family
HZR83_RS08990	COG2079	MmgE PrpD family protein
HZR83_RS08995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZR83_RS09000	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HZR83_RS09005	COG0402	S-adenosylhomocysteine deaminase activity
HZR83_RS09010	COG0583	DNA-binding transcription factor activity
HZR83_RS09015	COG0288	reversible hydration of carbon dioxide
HZR83_RS09025	COG2807	transmembrane transport
HZR83_RS09030	COG0110	maltose O-acetyltransferase activity
HZR83_RS09035	COG2223	nitrite transmembrane transporter activity
HZR83_RS09040	COG3250	beta-galactosidase activity
HZR83_RS09045	COG1609	Transcriptional regulator
HZR83_RS09050	COG1414	Transcriptional regulator
HZR83_RS09070	COG3971	2-oxopent-4-enoate hydratase activity
HZR83_RS09085	COG2814	Major facilitator Superfamily
HZR83_RS09090	COG3122	Protein conserved in bacteria
HZR83_RS09120	COG1215	transferase activity, transferring glycosyl groups
HZR83_RS09125	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HZR83_RS09130	COG4521	taurine ABC transporter
HZR83_RS09140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZR83_RS09145	COG2175	clavaminate synthase activity
HZR83_RS09150	COG0113	porphobilinogen synthase activity
HZR83_RS09155	COG3468	outer membrane autotransporter barrel domain protein
HZR83_RS09160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZR83_RS09165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZR83_RS09170	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HZR83_RS09190	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZR83_RS09205	COG1785	Belongs to the alkaline phosphatase family
HZR83_RS09215	COG3706	GGDEF domain
HZR83_RS09220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZR83_RS09240	COG4126	flavin adenine dinucleotide binding
HZR83_RS09265	COG1940	carbohydrate kinase activity
HZR83_RS09270	COG2814	Major facilitator Superfamily
HZR83_RS09275	COG0419	ATPase involved in DNA repair
HZR83_RS09280	COG0420	3'-5' exonuclease activity
HZR83_RS09285	COG0745	RESPONSE REGULATOR receiver
HZR83_RS09290	COG5002	protein histidine kinase activity
HZR83_RS09295	COG1114	Component of the transport system for branched-chain amino acids
HZR83_RS09300	COG1113	amino acid transport
HZR83_RS09305	COG0366	Alpha amylase catalytic
HZR83_RS09325	COG1862	Preprotein translocase
HZR83_RS09330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZR83_RS09335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZR83_RS09340	COG1403	HNH endonuclease
HZR83_RS09345	COG3248	Nucleoside-binding outer membrane protein
HZR83_RS09350	COG4238	major outer membrane lipoprotein
HZR83_RS09360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZR83_RS09360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZR83_RS09375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HZR83_RS09380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HZR83_RS09385	COG0667	Aldo Keto reductase
HZR83_RS09395	COG0142	geranyltranstransferase activity
HZR83_RS09410	COG0693	protein deglycase activity
HZR83_RS09415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HZR83_RS09425	COG2814	Major facilitator Superfamily
HZR83_RS09435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HZR83_RS09440	COG1845	cytochrome c oxidase, subunit III
HZR83_RS09445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZR83_RS09450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZR83_RS09455	COG2223	nitrite transmembrane transporter activity
HZR83_RS09460	COG3056	Lipoprotein
HZR83_RS09465	COG0271	Belongs to the BolA IbaG family
HZR83_RS09485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZR83_RS09490	COG0776	regulation of translation
HZR83_RS09495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HZR83_RS09500	COG1555	photosystem II stabilization
HZR83_RS09505	COG0824	Thioesterase
HZR83_RS09515	COG4533	DNA binding
HZR83_RS09525	COG1522	sequence-specific DNA binding
HZR83_RS09530	COG1132	(ABC) transporter
HZR83_RS09535	COG1132	(ABC) transporter
HZR83_RS09540	COG0347	Belongs to the P(II) protein family
HZR83_RS09545	COG0004	ammonium transporteR
HZR83_RS09550	COG1946	Acyl-CoA thioesterase
HZR83_RS09555	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HZR83_RS09560	COG3695	enzyme binding
HZR83_RS09570	COG5507	3-demethylubiquinone-9 3-methyltransferase
HZR83_RS09575	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HZR83_RS09585	COG0110	maltose O-acetyltransferase activity
HZR83_RS09600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZR83_RS09605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZR83_RS09610	COG1309	transcriptional regulator
HZR83_RS09615	COG1196	nuclear chromosome segregation
HZR83_RS09615	COG3264	Mechanosensitive ion channel
HZR83_RS09625	COG3923	Primosomal replication protein n
HZR83_RS09630	COG2832	Protein of unknown function (DUF454)
HZR83_RS09640	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZR83_RS09675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZR83_RS09680	COG4651	solute:proton antiporter activity
HZR83_RS09680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZR83_RS09685	COG2223	nitrite transmembrane transporter activity
HZR83_RS09690	COG0737	Belongs to the 5'-nucleotidase family
HZR83_RS09695	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZR83_RS09700	COG3735	TraB family
HZR83_RS09705	COG3093	addiction module antidote protein HigA
HZR83_RS09710	COG2217	Heavy metal translocating P-type atpase
HZR83_RS09715	COG2066	Belongs to the glutaminase family
HZR83_RS09720	COG0531	amino acid
HZR83_RS09725	COG0789	Transcriptional regulator
HZR83_RS09730	COG1585	Membrane protein implicated in regulation of membrane protease activity
HZR83_RS09735	COG0330	HflC and HflK could
HZR83_RS09740	COG4619	ABC transporter
HZR83_RS09745	COG0390	transport system, permease component
HZR83_RS09750	COG3118	belongs to the thioredoxin family
HZR83_RS09755	COG0300	oxidoreductase activity
HZR83_RS09760	COG2755	lipolytic protein G-D-S-L family
HZR83_RS09765	COG4181	ATPase activity
HZR83_RS09770	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HZR83_RS09775	COG3209	COG3209 Rhs family protein
HZR83_RS09785	COG3209	COG3209 Rhs family protein
HZR83_RS09810	COG0583	DNA-binding transcription factor activity
HZR83_RS09820	COG1414	Transcriptional regulator
HZR83_RS09825	COG3960	tartronate-semialdehyde synthase activity
HZR83_RS09830	COG3622	Belongs to the hyi family
HZR83_RS09835	COG2084	Dehydrogenase
HZR83_RS09840	COG1953	Uracil, thiamine, allantoin
HZR83_RS09850	COG2233	PERMEase
HZR83_RS09855	COG1929	Belongs to the glycerate kinase type-1 family
HZR83_RS09860	COG3257	ureidoglycine aminohydrolase activity
HZR83_RS09865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZR83_RS09870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HZR83_RS09875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZR83_RS09880	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZR83_RS09890	COG0549	Belongs to the carbamate kinase family
HZR83_RS09895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HZR83_RS09900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HZR83_RS09910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZR83_RS09920	COG1988	membrane-bound metal-dependent
HZR83_RS09925	COG2501	S4 domain
HZR83_RS09935	COG3539	Fimbrial protein
HZR83_RS09940	COG3121	Chaperone
HZR83_RS09945	COG3188	usher protein
HZR83_RS09950	COG3539	Fimbrial protein
HZR83_RS09955	COG3539	Fimbrial protein
HZR83_RS09960	COG2197	response regulator
HZR83_RS09970	COG2207	Transcriptional regulator
HZR83_RS09980	COG4783	chaperone-mediated protein folding
HZR83_RS09985	COG1215	transferase activity, transferring glycosyl groups
HZR83_RS09990	COG5002	protein histidine kinase activity
HZR83_RS09995	COG0745	RESPONSE REGULATOR receiver
HZR83_RS10000	COG1538	Outer membrane efflux protein
HZR83_RS10005	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZR83_RS10010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZR83_RS10015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZR83_RS10020	COG1113	amino acid transport
HZR83_RS10025	COG0668	transmembrane transport
HZR83_RS10030	COG0778	Nitroreductase
HZR83_RS10070	COG0438	transferase activity, transferring glycosyl groups
HZR83_RS10075	COG0438	transferase activity, transferring glycosyl groups
HZR83_RS10100	COG3423	Transcriptional regulator
HZR83_RS10130	COG3385	transposase activity
HZR83_RS10135	COG2977	Belongs to the P-Pant transferase superfamily
HZR83_RS10140	COG4771	TonB-dependent receptor
HZR83_RS10150	COG2382	esterase
HZR83_RS10155	COG3251	PFAM MbtH domain protein
HZR83_RS10160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZR83_RS10160	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HZR83_RS10165	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HZR83_RS10170	COG1120	ATPase activity
HZR83_RS10175	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZR83_RS10180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZR83_RS10190	COG4592	Periplasmic binding protein
HZR83_RS10195	COG1169	isochorismate synthase
HZR83_RS10200	COG1021	2,3-dihydroxybenzoate-AMP ligase
HZR83_RS10205	COG1535	isochorismatase
HZR83_RS10205	COG3433	isochorismatase activity
HZR83_RS10210	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS10215	COG2050	protein possibly involved in aromatic compounds catabolism
HZR83_RS10220	COG1966	Carbon starvation protein
HZR83_RS10225	COG2879	small protein
HZR83_RS10230	COG0371	Dehydrogenase
HZR83_RS10235	COG0436	Aminotransferase
HZR83_RS10240	COG1475	DNA binding
HZR83_RS10245	COG3969	phosphoadenosine phosphosulfate
HZR83_RS10250	COG0583	DNA-binding transcription factor activity
HZR83_RS10255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZR83_RS10260	COG0450	alkyl hydroperoxide reductase
HZR83_RS10265	COG3634	alkyl hydroperoxide reductase activity
HZR83_RS10270	COG0589	response to stress
HZR83_RS10275	COG1063	alcohol dehydrogenase
HZR83_RS10280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZR83_RS10285	COG3719	Belongs to the RNase T2 family
HZR83_RS10290	COG0471	metal ion transport
HZR83_RS10305	COG3051	citrate lyase alpha subunit
HZR83_RS10310	COG2301	Belongs to the HpcH HpaI aldolase family
HZR83_RS10320	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HZR83_RS10325	COG3290	protein histidine kinase activity
HZR83_RS10330	COG4565	transcriptional regulatory protein
HZR83_RS10335	COG3069	C4-dicarboxylate transmembrane transporter activity
HZR83_RS10360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZR83_RS10370	COG0583	DNA-binding transcription factor activity
HZR83_RS10385	COG1686	Belongs to the peptidase S11 family
HZR83_RS10390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZR83_RS10395	COG0772	Belongs to the SEDS family
HZR83_RS10400	COG0768	penicillin binding
HZR83_RS10410	COG0799	negative regulation of ribosome biogenesis
HZR83_RS10415	COG0406	alpha-ribazole phosphatase activity
HZR83_RS10425	COG1466	dna polymerase III delta subunit
HZR83_RS10440	COG2888	peptidyl-tyrosine sulfation
HZR83_RS10445	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HZR83_RS10455	COG2214	Heat shock protein DnaJ domain protein
HZR83_RS10460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HZR83_RS10470	COG2214	Heat shock protein DnaJ domain protein
HZR83_RS10475	COG0443	Heat shock 70 kDa protein
HZR83_RS10485	COG1126	abc transporter atp-binding protein
HZR83_RS10490	COG0765	amino acid transport
HZR83_RS10495	COG0765	amino acid transport
HZR83_RS10500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZR83_RS10505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HZR83_RS10510	COG4535	Mg2 and Co2 transporter CorC
HZR83_RS10520	COG1702	phosphate starvation-inducible protein PhoH
HZR83_RS10530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZR83_RS10570	COG0367	asparagine synthase
HZR83_RS10575	COG0647	UMP catabolic process
HZR83_RS10580	COG1940	carbohydrate kinase activity
HZR83_RS10580	COG1846	Transcriptional regulator
HZR83_RS10585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZR83_RS10595	COG1263	PTS System
HZR83_RS10595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS10595	COG2190	(PTS) system
HZR83_RS10615	COG0735	belongs to the Fur family
HZR83_RS10625	COG0716	FMN binding
HZR83_RS10635	COG0596	Alpha beta hydrolase
HZR83_RS10640	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HZR83_RS10645	COG0033	Phosphoglucomutase
HZR83_RS10665	COG0531	amino acid
HZR83_RS10680	COG0745	RESPONSE REGULATOR receiver
HZR83_RS10685	COG2205	protein histidine kinase activity
HZR83_RS10715	COG3209	COG3209 Rhs family protein
HZR83_RS10750	COG3272	Protein of unknown function (DUF1722)
HZR83_RS10755	COG0415	Belongs to the DNA photolyase family
HZR83_RS10760	COG3104	oligopeptide transport
HZR83_RS10765	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HZR83_RS10770	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HZR83_RS10775	COG1984	allophanate hydrolase subunit 2
HZR83_RS10790	COG3180	Ammonia monooxygenase
HZR83_RS10795	COG3539	Fimbrial protein
HZR83_RS10800	COG3121	Chaperone
HZR83_RS10805	COG3188	usher protein
HZR83_RS10810	COG3539	Fimbrial protein
HZR83_RS10815	COG0372	Belongs to the citrate synthase family
HZR83_RS10825	COG2009	succinate dehydrogenase
HZR83_RS10830	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HZR83_RS10835	COG1053	succinate dehydrogenase
HZR83_RS10840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZR83_RS10845	COG0567	Dehydrogenase, E1 component
HZR83_RS10850	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZR83_RS10860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZR83_RS10865	COG2188	Transcriptional regulator
HZR83_RS10870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS10870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS10870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS10875	COG0383	alpha-mannosidase activity
HZR83_RS10885	COG1271	oxidase subunit
HZR83_RS10890	COG1294	oxidase, subunit
HZR83_RS10895	COG4890	Cyd operon protein YbgT
HZR83_RS10900	COG3790	cyd operon protein YbgE
HZR83_RS10905	COG0824	Thioesterase
HZR83_RS10910	COG0811	peptide transport
HZR83_RS10915	COG0848	biopolymer transport protein
HZR83_RS10920	COG3064	Membrane
HZR83_RS10930	COG2885	chlorophyll binding
HZR83_RS10935	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HZR83_RS10985	COG3201	nicotinamide mononucleotide transporter
HZR83_RS10990	COG1230	cation diffusion facilitator family transporter
HZR83_RS11000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HZR83_RS11010	COG2017	converts alpha-aldose to the beta-anomer
HZR83_RS11020	COG1085	galactose-1-phosphate uridylyltransferase
HZR83_RS11025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZR83_RS11030	COG1119	ATPase activity
HZR83_RS11035	COG2005	Transcriptional regulator
HZR83_RS11035	COG3585	molybdate ion transport
HZR83_RS11045	COG0725	ABC transporter, periplasmic molybdate-binding protein
HZR83_RS11050	COG4149	molybdate abc transporter
HZR83_RS11055	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HZR83_RS11060	COG0561	phosphatase activity
HZR83_RS11070	COG0583	DNA-binding transcription factor activity
HZR83_RS11075	COG2828	Protein conserved in bacteria
HZR83_RS11080	COG0471	metal ion transport
HZR83_RS11085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HZR83_RS11090	COG4677	pectinesterase activity
HZR83_RS11095	COG1881	PFAM PEBP family protein
HZR83_RS11100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZR83_RS11115	COG2226	methyltransferase
HZR83_RS11120	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZR83_RS11130	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HZR83_RS11140	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZR83_RS11150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HZR83_RS11155	COG0314	molybdopterin synthase activity
HZR83_RS11160	COG0670	Belongs to the BI1 family
HZR83_RS11165	COG0670	Belongs to the BI1 family
HZR83_RS11170	COG0392	lysyltransferase activity
HZR83_RS11175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZR83_RS11180	COG3568	Endonuclease Exonuclease Phosphatase
HZR83_RS11190	COG0842	Transport permease protein
HZR83_RS11195	COG0842	Transport permease protein
HZR83_RS11200	COG1131	(ABC) transporter
HZR83_RS11210	COG1309	transcriptional regulator
HZR83_RS11215	COG0513	Belongs to the DEAD box helicase family
HZR83_RS11225	COG1199	ATP-dependent helicase activity
HZR83_RS11230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZR83_RS11235	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HZR83_RS11245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HZR83_RS11255	COG4774	siderophore transport
HZR83_RS11270	COG0668	transmembrane transport
HZR83_RS11275	COG1126	abc transporter atp-binding protein
HZR83_RS11280	COG0765	amino acid transport
HZR83_RS11285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZR83_RS11295	COG5006	permease, DMT superfamily
HZR83_RS11305	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HZR83_RS11310	COG2194	sulfuric ester hydrolase activity
HZR83_RS11320	COG1321	iron dependent repressor
HZR83_RS11325	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HZR83_RS11330	COG1376	ErfK ybiS ycfS ynhG family protein
HZR83_RS11335	COG0488	(ABC) transporter
HZR83_RS11345	COG0561	phosphatase activity
HZR83_RS11350	COG1882	Formate acetyltransferase
HZR83_RS11355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZR83_RS11360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZR83_RS11365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZR83_RS11370	COG0303	'Molybdopterin
HZR83_RS11375	COG1446	asparaginase
HZR83_RS11380	COG4172	Belongs to the ABC transporter superfamily
HZR83_RS11385	COG0747	negative chemotaxis
HZR83_RS11395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZR83_RS11400	COG2200	EAL domain
HZR83_RS11405	COG2199	diguanylate cyclase activity
HZR83_RS11420	COG2133	pyrroloquinoline quinone binding
HZR83_RS11425	COG0625	glutathione transferase activity
HZR83_RS11430	COG1686	Belongs to the peptidase S11 family
HZR83_RS11435	COG1349	DNA-binding transcription factor activity
HZR83_RS11440	COG0671	phosphoesterase, PA-phosphatase related
HZR83_RS11445	COG2814	Major facilitator Superfamily
HZR83_RS11455	COG0561	phosphatase activity
HZR83_RS11460	COG0738	Major facilitator superfamily
HZR83_RS11465	COG3226	Transcriptional regulator
HZR83_RS11480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HZR83_RS11490	COG0778	Nitroreductase
HZR83_RS11505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZR83_RS11510	COG3842	ATPase activity
HZR83_RS11515	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZR83_RS11520	COG1177	transmembrane transport
HZR83_RS11535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZR83_RS11540	COG4160	amino acid transport
HZR83_RS11545	COG4215	(ABC) transporter
HZR83_RS11550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZR83_RS11555	COG1126	abc transporter atp-binding protein
HZR83_RS11570	COG3023	N-Acetylmuramoyl-L-alanine amidase
HZR83_RS11575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZR83_RS11580	COG0702	epimerase
HZR83_RS11585	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HZR83_RS11590	COG0028	Belongs to the TPP enzyme family
HZR83_RS11595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZR83_RS11605	COG2431	L-lysine efflux transmembrane transporter activity
HZR83_RS11615	COG3593	DNA synthesis involved in DNA repair
HZR83_RS11620	COG2990	Protein conserved in bacteria
HZR83_RS11625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZR83_RS11630	COG1136	(ABC) transporter
HZR83_RS11630	COG0577	efflux transmembrane transporter activity
HZR83_RS11635	COG1278	Cold shock
HZR83_RS11645	COG0542	response to heat
HZR83_RS11665	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HZR83_RS11670	COG4988	ABC transporter
HZR83_RS11675	COG0492	ferredoxin-NADP+ reductase activity
HZR83_RS11680	COG1522	sequence-specific DNA binding
HZR83_RS11685	COG1674	ftsk spoiiie
HZR83_RS11685	COG1178	ABC-type Fe3 transport system permease component
HZR83_RS11695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZR83_RS11705	COG0243	molybdopterin cofactor binding
HZR83_RS11710	COG0437	4 iron, 4 sulfur cluster binding
HZR83_RS11715	COG3302	dmso reductase anchor subunit
HZR83_RS11720	COG1335	isochorismatase
HZR83_RS11730	COG0531	amino acid
HZR83_RS11735	COG0583	DNA-binding transcription factor activity
HZR83_RS11740	COG2249	NAD(P)H dehydrogenase (quinone) activity
HZR83_RS11745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZR83_RS11750	COG1882	Formate acetyltransferase
HZR83_RS11755	COG2116	formate transmembrane transporter activity
HZR83_RS11760	COG1944	ATP diphosphatase activity
HZR83_RS11765	COG2323	membrane
HZR83_RS11780	COG0501	Belongs to the peptidase M48B family
HZR83_RS11790	COG0539	negative regulation of cytoplasmic translation
HZR83_RS11800	COG2333	competence protein COMEC
HZR83_RS11800	COG0658	competence protein
HZR83_RS11805	COG1132	(ABC) transporter
HZR83_RS11810	COG1663	tetraacyldisaccharide 4'-kinase activity
HZR83_RS11815	COG3214	Protein conserved in bacteria
HZR83_RS11830	COG3173	Aminoglycoside phosphotransferase
HZR83_RS11835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HZR83_RS11840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZR83_RS11850	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HZR83_RS11860	COG2989	Protein conserved in bacteria
HZR83_RS11865	COG3108	Peptidase M15
HZR83_RS11870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZR83_RS11875	COG1448	Aminotransferase
HZR83_RS11880	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HZR83_RS11895	COG0308	aminopeptidase N
HZR83_RS11900	COG1116	anion transmembrane transporter activity
HZR83_RS11905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZR83_RS11915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZR83_RS11920	COG0431	NADPH-dependent FMN reductase
HZR83_RS11925	COG3539	Fimbrial protein
HZR83_RS11930	COG3121	Chaperone
HZR83_RS11935	COG3188	usher protein
HZR83_RS11940	COG3539	Fimbrial protein
HZR83_RS11945	COG3539	Fimbrial protein
HZR83_RS11950	COG3539	Fimbrial protein
HZR83_RS11955	COG3121	Chaperone
HZR83_RS11970	COG0633	Ferredoxin
HZR83_RS11970	COG3217	Mosc domain protein beta barrel domain protein
HZR83_RS11980	COG0488	(ABC) transporter
HZR83_RS11985	COG2995	paraquat-inducible protein a
HZR83_RS11990	COG3008	intermembrane lipid transfer
HZR83_RS11990	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZR83_RS11995	COG3009	Protein conserved in bacteria
HZR83_RS12000	COG3130	regulation of translation
HZR83_RS12010	COG1067	ATP-dependent peptidase activity
HZR83_RS12020	COG2885	chlorophyll binding
HZR83_RS12020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HZR83_RS12030	COG3070	regulator of competence-specific genes
HZR83_RS12035	COG1289	transmembrane transporter activity
HZR83_RS12040	COG3304	Inner membrane component domain
HZR83_RS12045	COG0210	DNA helicase
HZR83_RS12060	COG1832	CoA-binding protein
HZR83_RS12075	COG1254	Belongs to the acylphosphatase family
HZR83_RS12080	COG2920	part of a sulfur-relay system
HZR83_RS12085	COG0670	Belongs to the BI1 family
HZR83_RS12095	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HZR83_RS12100	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HZR83_RS12105	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HZR83_RS12110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZR83_RS12115	COG1999	signal sequence binding
HZR83_RS12120	COG1773	rubredoxin
HZR83_RS12125	COG1271	oxidase subunit
HZR83_RS12130	COG1294	oxidase, subunit
HZR83_RS12145	COG3206	protein involved in exopolysaccharide biosynthesis
HZR83_RS12145	COG0489	protein tyrosine kinase activity
HZR83_RS12150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZR83_RS12155	COG1596	polysaccharide export
HZR83_RS12160	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZR83_RS12180	COG1278	Cold shock
HZR83_RS12185	COG1278	Cold shock
HZR83_RS12205	COG0348	domain, Protein
HZR83_RS12210	COG0784	Response regulator, receiver
HZR83_RS12210	COG2205	protein histidine kinase activity
HZR83_RS12210	COG2198	Histidine kinase
HZR83_RS12215	COG1879	ABC-type sugar transport system periplasmic component
HZR83_RS12220	COG0745	RESPONSE REGULATOR receiver
HZR83_RS12225	COG3005	denitrification pathway
HZR83_RS12230	COG0243	molybdopterin cofactor binding
HZR83_RS12235	COG3381	protein complex oligomerization
HZR83_RS12270	COG3729	General stress protein
HZR83_RS12275	COG2233	PERMEase
HZR83_RS12310	COG1309	transcriptional regulator
HZR83_RS12315	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HZR83_RS12315	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HZR83_RS12315	COG0506	proline dehydrogenase activity
HZR83_RS12325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZR83_RS12335	COG2822	iron ion transport
HZR83_RS12340	COG2837	iron assimilation
HZR83_RS12345	COG1702	phosphate starvation-inducible protein PhoH
HZR83_RS12350	COG3658	cytochrome
HZR83_RS12355	COG1215	transferase activity, transferring glycosyl groups
HZR83_RS12360	COG1649	PFAM Uncharacterised BCR, COG1649
HZR83_RS12360	COG0726	polysaccharide deacetylase
HZR83_RS12365	COG0457	Tetratricopeptide repeat
HZR83_RS12370	COG3706	GGDEF domain
HZR83_RS12410	COG3381	protein complex oligomerization
HZR83_RS12420	COG1462	curli production assembly transport component CsgG
HZR83_RS12435	COG2197	response regulator
HZR83_RS12465	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HZR83_RS12470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZR83_RS12485	COG2943	transferase activity, transferring hexosyl groups
HZR83_RS12490	COG5645	(Lipo)protein
HZR83_RS12505	COG1560	Kdo2-lipid A biosynthetic process
HZR83_RS12515	COG2353	YceI-like domain
HZR83_RS12520	COG3038	cytochrome b561
HZR83_RS12555	COG2999	glutathione oxidoreductase activity
HZR83_RS12565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZR83_RS12575	COG0673	inositol 2-dehydrogenase activity
HZR83_RS12580	COG0728	peptidoglycan biosynthetic process
HZR83_RS12585	COG3418	PFAM FlgN family protein
HZR83_RS12590	COG2747	anti-sigma28 factor FlgM
HZR83_RS12595	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HZR83_RS12600	COG1815	bacterial-type flagellum-dependent cell motility
HZR83_RS12605	COG1558	bacterial-type flagellum-dependent cell motility
HZR83_RS12610	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HZR83_RS12615	COG1749	Flagellar hook protein flgE
HZR83_RS12625	COG4786	Flagellar basal body rod
HZR83_RS12640	COG3951	Flagellar rod assembly protein muramidase FlgJ
HZR83_RS12640	COG1705	Flagellar rod assembly protein muramidase FlgJ
HZR83_RS12645	COG1256	bacterial-type flagellum assembly
HZR83_RS12650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZR83_RS12655	COG1530	ribonuclease E activity
HZR83_RS12665	COG0564	pseudouridine synthase activity
HZR83_RS12670	COG0424	maF-like protein
HZR83_RS12675	COG1399	metal-binding, possibly nucleic acid-binding protein
HZR83_RS12695	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZR83_RS12700	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS12710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZR83_RS12715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZR83_RS12720	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZR83_RS12730	COG0470	DNA polymerase III
HZR83_RS12735	COG0084	hydrolase, TatD family'
HZR83_RS12740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS12740	COG1263	PTS System
HZR83_RS12745	COG4773	Receptor
HZR83_RS12750	COG0537	adenosine 5'-monophosphoramidase activity
HZR83_RS12755	COG5633	Lipoprotein
HZR83_RS12760	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HZR83_RS12780	COG1252	NADH dehydrogenase
HZR83_RS12785	COG3134	Outer membrane lipoprotein
HZR83_RS12790	COG1309	transcriptional regulator
HZR83_RS12800	COG1388	LysM domain
HZR83_RS12800	COG1376	ErfK ybiS ycfS ynhG family protein
HZR83_RS12805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZR83_RS12810	COG4763	Acyl-transferase
HZR83_RS12815	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZR83_RS12820	COG1136	(ABC) transporter
HZR83_RS12825	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZR83_RS12835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HZR83_RS12840	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HZR83_RS12850	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZR83_RS12855	COG1177	transmembrane transport
HZR83_RS12860	COG0582	viral genome integration into host DNA
HZR83_RS12870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZR83_RS12945	COG1403	HNH endonuclease
HZR83_RS12950	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HZR83_RS12955	COG0484	heat shock protein binding
HZR83_RS13000	COG3772	lysozyme
HZR83_RS13150	COG0500	methyltransferase
HZR83_RS13165	COG3842	ATPase activity
HZR83_RS13175	COG2850	peptidyl-arginine hydroxylation
HZR83_RS13180	COG2205	protein histidine kinase activity
HZR83_RS13185	COG0745	RESPONSE REGULATOR receiver
HZR83_RS13190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZR83_RS13210	COG1187	pseudouridine synthase activity
HZR83_RS13215	COG0538	isocitrate dehydrogenase activity
HZR83_RS13235	COG5562	phage envelope protein
HZR83_RS13240	COG0789	Transcriptional regulator
HZR83_RS13245	COG2200	EAL domain
HZR83_RS13270	COG2200	EAL domain
HZR83_RS13320	COG2894	cell division
HZR83_RS13350	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZR83_RS13365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZR83_RS13370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZR83_RS13375	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HZR83_RS13390	COG2719	SpoVR family
HZR83_RS13400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZR83_RS13410	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZR83_RS13420	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HZR83_RS13425	COG2261	transglycosylase associated protein
HZR83_RS13440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS13440	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HZR83_RS13440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZR83_RS13445	COG1461	Dihydroxyacetone kinase
HZR83_RS13450	COG2376	Dihydroxyacetone kinase
HZR83_RS13455	COG3284	Transcriptional regulator
HZR83_RS13460	COG3468	outer membrane autotransporter barrel domain protein
HZR83_RS13465	COG0012	GTP binding
HZR83_RS13480	COG0659	secondary active sulfate transmembrane transporter activity
HZR83_RS13485	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HZR83_RS13510	COG2890	protein-(glutamine-N5) methyltransferase activity
HZR83_RS13515	COG3094	Invasion gene expression up-regulator, SirB
HZR83_RS13520	COG2912	Transglutaminase-like superfamily
HZR83_RS13545	COG0387	Pfam Sodium calcium exchanger
HZR83_RS13550	COG4572	Cation transport regulator
HZR83_RS13555	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HZR83_RS13560	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HZR83_RS13565	COG4932	domain protein
HZR83_RS13570	COG2197	response regulator
HZR83_RS13575	COG3850	Histidine kinase
HZR83_RS13580	COG2223	nitrite transmembrane transporter activity
HZR83_RS13585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HZR83_RS13590	COG1140	nitrate reductase beta subunit
HZR83_RS13595	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HZR83_RS13600	COG2181	nitrate reductase activity
HZR83_RS13635	COG0788	formyltetrahydrofolate deformylase activity
HZR83_RS13645	COG1752	Esterase of the alpha-beta hydrolase superfamily
HZR83_RS13650	COG0745	RESPONSE REGULATOR receiver
HZR83_RS13655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZR83_RS13665	COG1435	thymidine kinase activity
HZR83_RS13675	COG1012	belongs to the aldehyde dehydrogenase family
HZR83_RS13675	COG1454	alcohol dehydrogenase
HZR83_RS13680	COG2095	MarC family integral membrane protein
HZR83_RS13690	COG4166	transmembrane transport
HZR83_RS13695	COG0601	transmembrane transport
HZR83_RS13700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZR83_RS13705	COG0444	Belongs to the ABC transporter superfamily
HZR83_RS13710	COG4608	Belongs to the ABC transporter superfamily
HZR83_RS13730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZR83_RS13735	COG2350	Protein conserved in bacteria
HZR83_RS13740	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HZR83_RS13745	COG1607	acyl-coa hydrolase
HZR83_RS13765	COG3047	cAMP biosynthetic process
HZR83_RS13770	COG3685	Protein conserved in bacteria
HZR83_RS13775	COG3685	Protein conserved in bacteria
HZR83_RS13780	COG3729	General stress protein
HZR83_RS13795	COG0134	indole-3-glycerol-phosphate synthase activity
HZR83_RS13795	COG0135	phosphoribosylanthranilate isomerase activity
HZR83_RS13800	COG0512	Glutamine amidotransferase of anthranilate synthase
HZR83_RS13800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZR83_RS13805	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZR83_RS13815	COG0613	PHP domain protein
HZR83_RS13820	COG0009	L-threonylcarbamoyladenylate synthase
HZR83_RS13825	COG4907	membrane protein (DUF2207)
HZR83_RS13830	COG1187	pseudouridine synthase activity
HZR83_RS13835	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HZR83_RS13840	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS13845	COG0616	signal peptide processing
HZR83_RS13855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZR83_RS13860	COG0583	DNA-binding transcription factor activity
HZR83_RS13885	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HZR83_RS13895	COG0671	phosphoesterase, PA-phosphatase related
HZR83_RS13900	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HZR83_RS13905	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HZR83_RS13915	COG0023	Translation Initiation Factor
HZR83_RS13925	COG1349	DNA-binding transcription factor activity
HZR83_RS13935	COG5001	Diguanylate cyclase
HZR83_RS13950	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZR83_RS13950	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZR83_RS13955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZR83_RS13960	COG2852	Protein conserved in bacteria
HZR83_RS13965	COG4172	Belongs to the ABC transporter superfamily
HZR83_RS13970	COG4172	Belongs to the ABC transporter superfamily
HZR83_RS13975	COG4171	peptide transport system, permease
HZR83_RS13980	COG4168	peptide transport system, permease
HZR83_RS13985	COG4166	transmembrane transport
HZR83_RS13995	COG0531	amino acid
HZR83_RS14005	COG0174	glutamine synthetase
HZR83_RS14010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZR83_RS14015	COG1917	Cupin 2, conserved barrel domain protein
HZR83_RS14015	COG1396	sequence-specific DNA binding
HZR83_RS14020	COG1012	belongs to the aldehyde dehydrogenase family
HZR83_RS14025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZR83_RS14030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZR83_RS14035	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HZR83_RS14040	COG1842	Phage shock protein A
HZR83_RS14050	COG1983	PspC domain protein
HZR83_RS14060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZR83_RS14065	COG0366	Alpha amylase catalytic
HZR83_RS14075	COG1175	transmembrane transport
HZR83_RS14080	COG0395	ABC-type sugar transport system, permease component
HZR83_RS14085	COG1063	alcohol dehydrogenase
HZR83_RS14090	COG1082	Xylose isomerase domain protein TIM barrel
HZR83_RS14095	COG0673	inositol 2-dehydrogenase activity
HZR83_RS14100	COG1554	hydrolase, family 65, central catalytic
HZR83_RS14105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZR83_RS14120	COG1609	Transcriptional regulator
HZR83_RS14125	COG3106	COG3106 Predicted ATPase
HZR83_RS14135	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HZR83_RS14140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HZR83_RS14145	COG4948	Mandelate Racemase Muconate Lactonizing
HZR83_RS14150	COG2866	Carboxypeptidase
HZR83_RS14165	COG1073	alpha beta
HZR83_RS14170	COG0583	DNA-binding transcription factor activity
HZR83_RS14175	COG4166	transmembrane transport
HZR83_RS14180	COG0668	transmembrane transport
HZR83_RS14185	COG3182	Iron-regulated membrane protein
HZR83_RS14190	COG0589	response to stress
HZR83_RS14195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZR83_RS14200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZR83_RS14205	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HZR83_RS14210	COG1473	amidohydrolase
HZR83_RS14215	COG1473	amidohydrolase
HZR83_RS14220	COG0583	DNA-binding transcription factor activity
HZR83_RS14225	COG2840	Smr protein MutS2
HZR83_RS14230	COG3706	GGDEF domain
HZR83_RS14240	COG0513	Belongs to the DEAD box helicase family
HZR83_RS14250	COG0589	response to stress
HZR83_RS14255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HZR83_RS14260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZR83_RS14260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZR83_RS14260	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZR83_RS14260	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZR83_RS14265	COG3042	response to heat
HZR83_RS14270	COG3187	Heat shock protein
HZR83_RS14275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZR83_RS14280	COG2911	Protein conserved in bacteria
HZR83_RS14290	COG3784	Protein of unknown function (DUF1318)
HZR83_RS14295	COG2207	Transcriptional regulator
HZR83_RS14300	COG1012	belongs to the aldehyde dehydrogenase family
HZR83_RS14305	COG3733	amine oxidase
HZR83_RS14310	COG1012	belongs to the aldehyde dehydrogenase family
HZR83_RS14310	COG2030	dehydratase
HZR83_RS14315	COG3396	Phenylacetate-CoA oxygenase
HZR83_RS14320	COG3460	Phenylacetate-CoA oxygenase
HZR83_RS14325	COG3396	Phenylacetate-CoA oxygenase
HZR83_RS14330	COG2151	metal-sulfur cluster biosynthetic enzyme
HZR83_RS14335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZR83_RS14340	COG1024	Enoyl-CoA hydratase
HZR83_RS14345	COG1024	Enoyl-CoA hydratase
HZR83_RS14350	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZR83_RS14355	COG2050	protein possibly involved in aromatic compounds catabolism
HZR83_RS14360	COG0183	Belongs to the thiolase family
HZR83_RS14365	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HZR83_RS14370	COG3327	negative regulation of DNA-templated transcription, initiation
HZR83_RS14375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZR83_RS14400	COG0667	Aldo Keto reductase
HZR83_RS14410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZR83_RS14415	COG4589	Belongs to the CDS family
HZR83_RS14420	COG2267	carboxylic ester hydrolase activity
HZR83_RS14425	COG2453	phosphatase
HZR83_RS14425	COG0671	phosphoesterase, PA-phosphatase related
HZR83_RS14435	COG1643	Atp-dependent helicase
HZR83_RS14440	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HZR83_RS14445	COG1012	belongs to the aldehyde dehydrogenase family
HZR83_RS14455	COG3038	cytochrome b561
HZR83_RS14470	COG0840	transmembrane signaling receptor activity
HZR83_RS14475	COG0583	DNA-binding transcription factor activity
HZR83_RS14480	COG5383	Protein conserved in bacteria
HZR83_RS14490	COG2841	Protein conserved in bacteria
HZR83_RS14495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZR83_RS14500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HZR83_RS14505	COG1275	C4-dicarboxylate transporter malic acid transport protein
HZR83_RS14510	COG0500	methyltransferase
HZR83_RS14525	COG0675	Transposase, IS605 OrfB family
HZR83_RS14530	COG3135	benzoate transporter
HZR83_RS14535	COG1396	sequence-specific DNA binding
HZR83_RS14540	COG0826	peptidase U32
HZR83_RS14550	COG1724	mRNA binding
HZR83_RS14555	COG1598	PFAM Uncharacterised protein family UPF0150
HZR83_RS14560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZR83_RS14565	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HZR83_RS14570	COG3842	ATPase activity
HZR83_RS14575	COG1176	ABC-type spermidine putrescine transport system, permease component I
HZR83_RS14580	COG1177	transmembrane transport
HZR83_RS14605	COG3238	Protein conserved in bacteria
HZR83_RS14610	COG1247	-acetyltransferase
HZR83_RS14615	COG2130	NADP-dependent
HZR83_RS14620	COG1802	Transcriptional regulator
HZR83_RS14625	COG4772	TonB-dependent receptor
HZR83_RS14630	COG3391	amine dehydrogenase activity
HZR83_RS14635	COG1113	amino acid transport
HZR83_RS14640	COG0625	glutathione transferase activity
HZR83_RS14650	COG3501	Rhs element vgr protein
HZR83_RS14655	COG3209	COG3209 Rhs family protein
HZR83_RS14675	COG5433	transposase activity
HZR83_RS14685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZR83_RS14690	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HZR83_RS14695	COG0384	phenazine biosynthesis protein PhzF
HZR83_RS14700	COG2181	nitrate reductase activity
HZR83_RS14705	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HZR83_RS14710	COG1140	nitrate reductase beta subunit
HZR83_RS14720	COG2223	nitrite transmembrane transporter activity
HZR83_RS14730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HZR83_RS14735	COG0697	spore germination
HZR83_RS14745	COG0437	4 iron, 4 sulfur cluster binding
HZR83_RS14750	COG2864	formate dehydrogenase
HZR83_RS14755	COG3093	addiction module antidote protein HigA
HZR83_RS14760	COG1064	alcohol dehydrogenase
HZR83_RS14780	COG1764	response to oxidative stress
HZR83_RS14785	COG4608	Belongs to the ABC transporter superfamily
HZR83_RS14790	COG0444	Belongs to the ABC transporter superfamily
HZR83_RS14795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZR83_RS14800	COG0601	transmembrane transport
HZR83_RS14805	COG0747	negative chemotaxis
HZR83_RS14810	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HZR83_RS14815	COG2200	EAL domain
HZR83_RS14815	COG2202	Pas domain
HZR83_RS14815	COG2199	diguanylate cyclase activity
HZR83_RS14820	COG3706	GGDEF domain
HZR83_RS14835	COG0531	amino acid
HZR83_RS14840	COG0076	glutamate decarboxylase activity
HZR83_RS14845	COG0612	Peptidase, M16
HZR83_RS14850	COG4771	TonB-dependent receptor
HZR83_RS14855	COG4178	(ABC) transporter
HZR83_RS14865	COG0641	radical SAM
HZR83_RS14870	COG3119	arylsulfatase activity
HZR83_RS14875	COG2207	Transcriptional regulator
HZR83_RS14885	COG0243	molybdopterin cofactor binding
HZR83_RS14890	COG3539	Fimbrial protein
HZR83_RS14895	COG3539	Fimbrial protein
HZR83_RS14910	COG3344	reverse transcriptase
HZR83_RS14935	COG3550	peptidyl-serine autophosphorylation
HZR83_RS14940	COG1396	sequence-specific DNA binding
HZR83_RS15000	COG3781	membrane
HZR83_RS15020	COG2066	Belongs to the glutaminase family
HZR83_RS15025	COG1012	belongs to the aldehyde dehydrogenase family
HZR83_RS15030	COG0583	DNA-binding transcription factor activity
HZR83_RS15050	COG1846	Transcriptional regulator
HZR83_RS15055	COG4977	sequence-specific DNA binding
HZR83_RS15070	COG2814	Major facilitator Superfamily
HZR83_RS15080	COG3706	GGDEF domain
HZR83_RS15085	COG3111	PFAM Bacterial OB fold (BOF) protein
HZR83_RS15090	COG1546	Belongs to the CinA family
HZR83_RS15095	COG0339	signal peptide processing
HZR83_RS15100	COG4221	oxidoreductase activity
HZR83_RS15105	COG1802	Transcriptional regulator
HZR83_RS15115	COG0246	Mannitol dehydrogenase
HZR83_RS15120	COG0477	Major facilitator Superfamily
HZR83_RS15125	COG1063	alcohol dehydrogenase
HZR83_RS15130	COG4948	Mandelate Racemase Muconate Lactonizing
HZR83_RS15145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZR83_RS15160	COG0243	molybdopterin cofactor binding
HZR83_RS15165	COG0243	molybdopterin cofactor binding
HZR83_RS15170	COG0437	4 iron, 4 sulfur cluster binding
HZR83_RS15175	COG3302	dmso reductase anchor subunit
HZR83_RS15180	COG3381	protein complex oligomerization
HZR83_RS15190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZR83_RS15195	COG1940	carbohydrate kinase activity
HZR83_RS15200	COG0583	DNA-binding transcription factor activity
HZR83_RS15205	COG2814	Major facilitator Superfamily
HZR83_RS15220	COG3591	Belongs to the peptidase S1B family
HZR83_RS15235	COG0628	permease
HZR83_RS15240	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HZR83_RS15245	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HZR83_RS15255	COG0531	amino acid
HZR83_RS15265	COG3136	membrane protein required for alginate biosynthesis
HZR83_RS15270	COG0745	RESPONSE REGULATOR receiver
HZR83_RS15275	COG2205	protein histidine kinase activity
HZR83_RS15285	COG0114	fumarate hydratase activity
HZR83_RS15290	COG3385	transposase activity
HZR83_RS15295	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HZR83_RS15295	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HZR83_RS15300	COG1482	cell wall glycoprotein biosynthetic process
HZR83_RS15305	COG5339	Protein conserved in bacteria
HZR83_RS15320	COG3250	beta-galactosidase activity
HZR83_RS15325	COG1309	transcriptional regulator
HZR83_RS15330	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS15335	COG1609	Transcriptional regulator
HZR83_RS15340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS15340	COG1263	PTS System
HZR83_RS15345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZR83_RS15355	COG0673	inositol 2-dehydrogenase activity
HZR83_RS15395	COG4659	FMN binding
HZR83_RS15405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZR83_RS15410	COG3104	oligopeptide transport
HZR83_RS15415	COG0625	glutathione transferase activity
HZR83_RS15420	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HZR83_RS15435	COG3895	Periplasmic Protein
HZR83_RS15445	COG3133	Outer membrane lipoprotein
HZR83_RS15460	COG1566	PFAM secretion protein HlyD family protein
HZR83_RS15465	COG1289	transmembrane transporter activity
HZR83_RS15470	COG2032	superoxide dismutase activity
HZR83_RS15475	COG4989	oxidoreductase activity
HZR83_RS15480	COG3313	Fe-S protein
HZR83_RS15485	COG1309	transcriptional regulator
HZR83_RS15490	COG1902	pentaerythritol trinitrate reductase activity
HZR83_RS15495	COG0346	lactoylglutathione lyase activity
HZR83_RS15505	COG1201	RNA secondary structure unwinding
HZR83_RS15510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZR83_RS15520	COG0791	NLP P60 protein
HZR83_RS15525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZR83_RS15530	COG2814	Major facilitator Superfamily
HZR83_RS15545	COG0583	DNA-binding transcription factor activity
HZR83_RS15550	COG2814	Major facilitator Superfamily
HZR83_RS15555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZR83_RS15560	COG0307	riboflavin synthase, alpha
HZR83_RS15570	COG3468	outer membrane autotransporter barrel domain protein
HZR83_RS15590	COG4529	Protein conserved in bacteria
HZR83_RS15600	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HZR83_RS15605	COG0437	4 iron, 4 sulfur cluster binding
HZR83_RS15615	COG2414	aldehyde ferredoxin oxidoreductase
HZR83_RS15620	COG0437	4 iron, 4 sulfur cluster binding
HZR83_RS15630	COG0469	pyruvate kinase activity
HZR83_RS15635	COG4238	major outer membrane lipoprotein
HZR83_RS15640	COG1376	ErfK ybiS ycfS ynhG family protein
HZR83_RS15655	COG0719	Fe-S assembly protein
HZR83_RS15660	COG0396	ATPase activity
HZR83_RS15665	COG0719	Fe-S assembly protein
HZR83_RS15670	COG0316	Belongs to the HesB IscA family
HZR83_RS15680	COG2050	protein possibly involved in aromatic compounds catabolism
HZR83_RS15685	COG0277	FAD linked oxidase domain protein
HZR83_RS15685	COG0247	lactate metabolic process
HZR83_RS15690	COG0628	permease
HZR83_RS15715	COG4670	ketone body catabolic process
HZR83_RS15730	COG2271	Major facilitator Superfamily
HZR83_RS15745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZR83_RS15745	COG0574	Belongs to the PEP-utilizing enzyme family
HZR83_RS15755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HZR83_RS15760	COG4256	Hemin uptake protein
HZR83_RS15770	COG2200	EAL domain
HZR83_RS15775	COG0791	NLP P60 protein
HZR83_RS15785	COG0386	Belongs to the glutathione peroxidase family
HZR83_RS15845	COG3137	Salt-induced outer membrane protein
HZR83_RS15850	COG1105	Belongs to the carbohydrate kinase PfkB family
HZR83_RS15860	COG3001	Fructosamine kinase
HZR83_RS15870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZR83_RS15875	COG1988	membrane-bound metal-dependent
HZR83_RS15900	COG0753	catalase activity
HZR83_RS15910	COG1486	melibiose metabolic process
HZR83_RS15915	COG2169	Transcriptional regulator
HZR83_RS15915	COG1917	Cupin 2, conserved barrel domain protein
HZR83_RS15920	COG1447	Phosphotransferase system cellobiose-specific component IIA
HZR83_RS15925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZR83_RS15930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HZR83_RS15935	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZR83_RS15945	COG0322	excinuclease ABC activity
HZR83_RS15955	COG3678	ATP-independent chaperone mediated protein folding
HZR83_RS15985	COG0708	Exodeoxyribonuclease III
HZR83_RS15990	COG0398	Pfam SNARE associated Golgi protein
HZR83_RS16000	COG0398	Pfam SNARE associated Golgi protein
HZR83_RS16005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HZR83_RS16010	COG4134	Bacterial extracellular solute-binding protein
HZR83_RS16015	COG4135	transport system, permease component
HZR83_RS16020	COG4136	ATPase activity
HZR83_RS16025	COG2897	thiosulfate sulfurtransferase activity
HZR83_RS16030	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZR83_RS16035	COG0494	nUDIX hydrolase
HZR83_RS16045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZR83_RS16055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZR83_RS16065	COG0778	Nitroreductase
HZR83_RS16070	COG0616	signal peptide processing
HZR83_RS16075	COG0252	asparaginase activity
HZR83_RS16080	COG1335	isochorismatase
HZR83_RS16085	COG2814	Major facilitator Superfamily
HZR83_RS16090	COG1349	DNA-binding transcription factor activity
HZR83_RS16095	COG0667	Aldo Keto reductase
HZR83_RS16115	COG1063	alcohol dehydrogenase
HZR83_RS16120	COG3139	Protein of unknown function (DUF1315)
HZR83_RS16130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HZR83_RS16135	COG0676	glucose-6-phosphate 1-epimerase activity
HZR83_RS16140	COG0656	L-ascorbic acid biosynthetic process
HZR83_RS16145	COG3713	MltA-interacting MipA family protein
HZR83_RS16150	COG2766	serine protein kinase
HZR83_RS16160	COG2199	diguanylate cyclase activity
HZR83_RS16165	COG2199	diguanylate cyclase activity
HZR83_RS16170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZR83_RS16185	COG2207	Transcriptional regulator
HZR83_RS16195	COG3189	MarR family transcriptional regulator
HZR83_RS16200	COG3042	response to heat
HZR83_RS16205	COG2203	Gaf domain
HZR83_RS16205	COG2199	diguanylate cyclase activity
HZR83_RS16220	COG2261	transglycosylase associated protein
HZR83_RS16230	COG3615	Tellurite resistance protein tehB
HZR83_RS16240	COG0583	DNA-binding transcription factor activity
HZR83_RS16245	COG0473	3-isopropylmalate dehydrogenase activity
HZR83_RS16255	COG4638	Rieske (2fe-2S)
HZR83_RS16260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZR83_RS16265	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HZR83_RS16270	COG0318	PFAM AMP-dependent synthetase and ligase
HZR83_RS16275	COG3065	identical protein binding
HZR83_RS16280	COG1214	PFAM Peptidase M22, glycoprotease
HZR83_RS16285	COG1199	ATP-dependent helicase activity
HZR83_RS16290	COG0251	oxidation-reduction process
HZR83_RS16305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZR83_RS16315	COG1760	l-serine dehydratase
HZR83_RS16320	COG2200	EAL domain
HZR83_RS16325	COG1253	flavin adenine dinucleotide binding
HZR83_RS16330	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS16330	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS16335	COG3715	PTS system
HZR83_RS16340	COG3716	PTS system mannose fructose sorbose family IID component
HZR83_RS16355	COG2226	methyltransferase
HZR83_RS16385	COG1414	Transcriptional regulator
HZR83_RS16390	COG2814	Major facilitator Superfamily
HZR83_RS16400	COG0793	Belongs to the peptidase S41A family
HZR83_RS16410	COG1956	GAF domain-containing protein
HZR83_RS16415	COG2995	paraquat-inducible protein a
HZR83_RS16420	COG3008	intermembrane lipid transfer
HZR83_RS16440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZR83_RS16450	COG1276	copper resistance
HZR83_RS16455	COG2372	response to copper ion
HZR83_RS16465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZR83_RS16470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZR83_RS16475	COG1770	oligopeptidase
HZR83_RS16480	COG2979	Protein of unknown function (DUF533)
HZR83_RS16490	COG3141	response to X-ray
HZR83_RS16500	COG0800	Aldolase
HZR83_RS16505	COG0129	dihydroxy-acid dehydratase activity
HZR83_RS16510	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZR83_RS16515	COG1737	Transcriptional regulator
HZR83_RS16520	COG0469	pyruvate kinase activity
HZR83_RS16525	COG1560	Kdo2-lipid A biosynthetic process
HZR83_RS16530	COG0739	heme binding
HZR83_RS16535	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HZR83_RS16545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZR83_RS16580	COG0217	transcriptional regulatory protein
HZR83_RS16585	COG0494	nUDIX hydrolase
HZR83_RS16595	COG1335	isochorismatase
HZR83_RS16600	COG1801	Protein of unknown function DUF72
HZR83_RS16605	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HZR83_RS16620	COG0243	molybdopterin cofactor binding
HZR83_RS16625	COG3005	denitrification pathway
HZR83_RS16635	COG3102	Protein conserved in bacteria
HZR83_RS16650	COG3755	Protein conserved in bacteria
HZR83_RS16660	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZR83_RS16665	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZR83_RS16670	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HZR83_RS16675	COG0745	RESPONSE REGULATOR receiver
HZR83_RS16680	COG2201	protein-glutamate methylesterase activity
HZR83_RS16685	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HZR83_RS16690	COG0840	transmembrane signaling receptor activity
HZR83_RS16695	COG0840	transmembrane signaling receptor activity
HZR83_RS16700	COG0835	chemotaxis
HZR83_RS16710	COG1360	Flagellar Motor Protein
HZR83_RS16715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZR83_RS16730	COG0589	response to stress
HZR83_RS16740	COG1877	trehalose-phosphatase activity
HZR83_RS16745	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZR83_RS16755	COG1879	ABC-type sugar transport system periplasmic component
HZR83_RS16760	COG1528	Iron-storage protein
HZR83_RS16780	COG1528	Iron-storage protein
HZR83_RS16790	COG0814	amino acid
HZR83_RS16795	COG3012	SEC-C Motif Domain Protein
HZR83_RS16795	COG3318	Belongs to the UPF0149 family
HZR83_RS16805	COG3344	reverse transcriptase
HZR83_RS16845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HZR83_RS16855	COG3318	Belongs to the UPF0149 family
HZR83_RS16855	COG3012	SEC-C Motif Domain Protein
HZR83_RS16860	COG0732	type I restriction modification DNA specificity domain
HZR83_RS16935	COG2197	response regulator
HZR83_RS16950	COG2197	response regulator
HZR83_RS16980	COG1191	sigma factor activity
HZR83_RS17005	COG1516	flagellar protein fliS
HZR83_RS17015	COG0366	Alpha amylase catalytic
HZR83_RS17025	COG2391	methyltransferase activity
HZR83_RS17030	COG0425	Belongs to the sulfur carrier protein TusA family
HZR83_RS17040	COG0675	Transposase, IS605 OrfB family
HZR83_RS17055	COG2076	Multidrug Resistance protein
HZR83_RS17060	COG1881	PFAM PEBP family protein
HZR83_RS17100	COG5475	Uncharacterized small protein (DUF2158)
HZR83_RS17105	COG2354	Protein conserved in bacteria
HZR83_RS17110	COG0697	spore germination
HZR83_RS17115	COG3727	T/G mismatch-specific endonuclease activity
HZR83_RS17120	COG0270	DNA (cytosine-5-)-methyltransferase activity
HZR83_RS17125	COG1418	mRNA catabolic process
HZR83_RS17135	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HZR83_RS17145	COG2205	protein histidine kinase activity
HZR83_RS17150	COG0745	RESPONSE REGULATOR receiver
HZR83_RS17155	COG2351	hydroxyisourate hydrolase activity
HZR83_RS17170	COG3443	Belongs to the bacterial solute-binding protein 9 family
HZR83_RS17205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HZR83_RS17210	COG0217	transcriptional regulatory protein
HZR83_RS17230	COG0583	DNA-binding transcription factor activity
HZR83_RS17235	COG0583	DNA-binding transcription factor activity
HZR83_RS17245	COG1376	ErfK ybiS ycfS ynhG family protein
HZR83_RS17260	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HZR83_RS17295	COG2003	Belongs to the UPF0758 family
HZR83_RS17330	COG4917	ethanolamine utilization protein
HZR83_RS17340	COG1289	transmembrane transporter activity
HZR83_RS17350	COG1686	Belongs to the peptidase S11 family
HZR83_RS17355	COG2925	Exonuclease
HZR83_RS17360	COG0425	Belongs to the sulfur carrier protein TusA family
HZR83_RS17365	COG2391	methyltransferase activity
HZR83_RS17370	COG0531	amino acid
HZR83_RS17380	COG0583	DNA-binding transcription factor activity
HZR83_RS17385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZR83_RS17390	COG4115	mRNA cleavage
HZR83_RS17395	COG2161	toxin-antitoxin pair type II binding
HZR83_RS17420	COG0131	Imidazoleglycerol-phosphate dehydratase
HZR83_RS17420	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZR83_RS17425	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HZR83_RS17440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HZR83_RS17440	COG0140	phosphoribosyl-ATP diphosphatase activity
HZR83_RS17480	COG1088	dTDP-glucose 4,6-dehydratase activity
HZR83_RS17520	COG0463	Glycosyl transferase, family 2
HZR83_RS17530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZR83_RS17575	COG1253	flavin adenine dinucleotide binding
HZR83_RS17580	COG2982	Protein involved in outer membrane biogenesis
HZR83_RS17590	COG0572	uridine kinase
HZR83_RS17595	COG5001	Diguanylate cyclase
HZR83_RS17595	COG5002	protein histidine kinase activity
HZR83_RS17595	COG3447	MASE1 domain protein
HZR83_RS17600	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HZR83_RS17605	COG0443	Heat shock 70 kDa protein
HZR83_RS17620	COG0631	protein serine/threonine phosphatase activity
HZR83_RS17625	COG4245	von Willebrand factor, type A
HZR83_RS17665	COG2205	protein histidine kinase activity
HZR83_RS17670	COG0745	RESPONSE REGULATOR receiver
HZR83_RS17685	COG0653	protein targeting
HZR83_RS17735	COG5301	cellulose 1,4-beta-cellobiosidase activity
HZR83_RS17825	COG4695	Portal protein
HZR83_RS17885	COG4974	Belongs to the 'phage' integrase family
HZR83_RS17905	COG1063	alcohol dehydrogenase
HZR83_RS17910	COG3775	system Galactitol-specific IIC component
HZR83_RS17915	COG3414	Phosphotransferase system galactitol-specific IIB component
HZR83_RS17920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS17935	COG1830	Aldolase
HZR83_RS17940	COG2211	Major facilitator Superfamily
HZR83_RS17945	COG1397	ADP-ribosylglycohydrolase
HZR83_RS17950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZR83_RS17955	COG2188	Transcriptional regulator
HZR83_RS17960	COG3757	hydrolase, family 25
HZR83_RS17965	COG0351	phosphomethylpyrimidine kinase
HZR83_RS17980	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HZR83_RS17985	COG5455	response to cobalt ion
HZR83_RS17990	COG3539	Fimbrial protein
HZR83_RS17995	COG3188	usher protein
HZR83_RS18000	COG3121	Chaperone
HZR83_RS18005	COG3539	Fimbrial protein
HZR83_RS18015	COG0489	protein tyrosine kinase activity
HZR83_RS18025	COG3831	ATPase activity
HZR83_RS18030	COG3831	ATPase activity
HZR83_RS18040	COG0714	Associated with various cellular activities
HZR83_RS18045	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HZR83_RS18050	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HZR83_RS18055	COG4715	Zinc finger, swim domain protein
HZR83_RS18060	COG4808	Protein conserved in bacteria
HZR83_RS18065	COG4807	Protein conserved in bacteria
HZR83_RS18070	COG3279	Response regulator of the LytR AlgR family
HZR83_RS18075	COG3275	phosphorelay sensor kinase activity
HZR83_RS18090	COG1174	glycine betaine transport
HZR83_RS18095	COG1125	glycine betaine transport
HZR83_RS18100	COG1174	glycine betaine transport
HZR83_RS18105	COG1732	Glycine betaine
HZR83_RS18110	COG1472	Belongs to the glycosyl hydrolase 3 family
HZR83_RS18115	COG0277	FAD linked oxidase domain protein
HZR83_RS18120	COG1686	Belongs to the peptidase S11 family
HZR83_RS18130	COG0586	Pfam SNARE associated Golgi protein
HZR83_RS18135	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS18150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZR83_RS18160	COG1346	cytolysis
HZR83_RS18170	COG2949	membrane
HZR83_RS18180	COG0493	'glutamate synthase
HZR83_RS18185	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HZR83_RS18185	COG0167	dihydroorotate dehydrogenase activity
HZR83_RS18190	COG4211	Belongs to the binding-protein-dependent transport system permease family
HZR83_RS18195	COG1129	ABC transporter
HZR83_RS18200	COG1879	ABC-type sugar transport system periplasmic component
HZR83_RS18205	COG1609	Transcriptional regulator
HZR83_RS18210	COG2311	Membrane
HZR83_RS18225	COG4771	TonB-dependent receptor
HZR83_RS18230	COG0833	amino acid
HZR83_RS18235	COG0583	DNA-binding transcription factor activity
HZR83_RS18240	COG2855	membrane
HZR83_RS18265	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZR83_RS18275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZR83_RS18280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZR83_RS18285	COG2313	pseudouridylate synthase activity
HZR83_RS18290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZR83_RS18295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS18295	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HZR83_RS18295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS18300	COG1105	Belongs to the carbohydrate kinase PfkB family
HZR83_RS18305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS18305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS18310	COG2814	Major facilitator Superfamily
HZR83_RS18325	COG0246	Mannitol dehydrogenase
HZR83_RS18330	COG0523	cobalamin synthesis protein
HZR83_RS18335	COG0671	phosphoesterase, PA-phosphatase related
HZR83_RS18340	COG0791	NLP P60 protein
HZR83_RS18345	COG2200	EAL domain
HZR83_RS18350	COG4166	transmembrane transport
HZR83_RS18355	COG4174	ABC transporter (Permease)
HZR83_RS18360	COG4239	(ABC) transporter, permease
HZR83_RS18365	COG4172	Belongs to the ABC transporter superfamily
HZR83_RS18375	COG2814	Major facilitator Superfamily
HZR83_RS18380	COG1187	pseudouridine synthase activity
HZR83_RS18385	COG1061	Type III restriction enzyme res subunit
HZR83_RS18405	COG3083	sulfuric ester hydrolase activity
HZR83_RS18420	COG2197	response regulator
HZR83_RS18425	COG3088	subunit of a heme lyase
HZR83_RS18425	COG4235	cytochrome complex assembly
HZR83_RS18430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZR83_RS18435	COG1138	Cytochrome C-type biogenesis protein
HZR83_RS18445	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZR83_RS18450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZR83_RS18455	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZR83_RS18460	COG4133	protoheme IX ABC transporter activity
HZR83_RS18465	COG3005	denitrification pathway
HZR83_RS18470	COG3043	anaerobic respiration
HZR83_RS18475	COG0348	domain, Protein
HZR83_RS18480	COG0437	4 iron, 4 sulfur cluster binding
HZR83_RS18490	COG3062	negative regulation of establishment of protein localization
HZR83_RS18495	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZR83_RS18495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZR83_RS18515	COG4615	Cyclic peptide transporter
HZR83_RS18520	COG3145	DNA-N1-methyladenine dioxygenase activity
HZR83_RS18525	COG2169	Transcriptional regulator
HZR83_RS18525	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZR83_RS18530	COG1477	protein flavinylation
HZR83_RS18535	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HZR83_RS18540	COG0642	Histidine kinase
HZR83_RS18540	COG2198	Histidine kinase
HZR83_RS18545	COG2197	response regulator
HZR83_RS18550	COG2205	protein histidine kinase activity
HZR83_RS18550	COG0784	Response regulator, receiver
HZR83_RS18555	COG3852	Histidine kinase
HZR83_RS18560	COG2204	response regulator
HZR83_RS18565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HZR83_RS18570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HZR83_RS18575	COG2031	fatty acid transporter
HZR83_RS18580	COG0183	Belongs to the thiolase family
HZR83_RS18585	COG4676	Protein conserved in bacteria
HZR83_RS18590	COG5445	Predicted secreted protein (DUF2300)
HZR83_RS18595	COG2373	Large extracellular alpha-helical protein
HZR83_RS18600	COG3234	Protein of unknown function (DUF1175)
HZR83_RS18605	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HZR83_RS18610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZR83_RS18620	COG3468	outer membrane autotransporter barrel domain protein
HZR83_RS18625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZR83_RS18630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZR83_RS18635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZR83_RS18640	COG3642	lipopolysaccharide core region biosynthetic process
HZR83_RS18645	COG2814	Major facilitator Superfamily
HZR83_RS18650	COG0583	DNA-binding transcription factor activity
HZR83_RS18655	COG0584	glycerophosphoryl diester phosphodiesterase
HZR83_RS18660	COG2271	Major facilitator Superfamily
HZR83_RS18665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HZR83_RS18675	COG0247	lactate metabolic process
HZR83_RS18680	COG5464	transposase or invertase
HZR83_RS18695	COG2271	Major facilitator Superfamily
HZR83_RS18705	COG1414	Transcriptional regulator
HZR83_RS18770	COG0318	PFAM AMP-dependent synthetase and ligase
HZR83_RS18780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HZR83_RS18795	COG1169	isochorismate synthase
HZR83_RS18800	COG4575	ribosome binding
HZR83_RS18805	COG2153	protein acetylation
HZR83_RS18820	COG2234	aminopeptidase activity
HZR83_RS18835	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZR83_RS18840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZR83_RS18850	COG0839	Belongs to the complex I subunit 6 family
HZR83_RS18865	COG1034	ATP synthesis coupled electron transport
HZR83_RS18870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HZR83_RS18875	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HZR83_RS18895	COG0583	DNA-binding transcription factor activity
HZR83_RS18900	COG0436	Aminotransferase
HZR83_RS18910	COG0471	metal ion transport
HZR83_RS18910	COG0490	domain, Protein
HZR83_RS18915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZR83_RS18930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HZR83_RS18935	COG0857	belongs to the CobB CobQ family
HZR83_RS18935	COG0280	phosphate acetyltransferase
HZR83_RS18940	COG1288	antiporter activity
HZR83_RS18945	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HZR83_RS18950	COG0622	Phosphoesterase
HZR83_RS18955	COG0625	glutathione transferase activity
HZR83_RS18960	COG0625	glutathione transferase activity
HZR83_RS18965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZR83_RS18970	COG1090	epimerase
HZR83_RS18975	COG5464	transposase or invertase
HZR83_RS18980	COG4598	ABC transporter
HZR83_RS18985	COG4160	amino acid transport
HZR83_RS18990	COG4215	(ABC) transporter
HZR83_RS18995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZR83_RS19000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZR83_RS19005	COG0163	prenyltransferase activity
HZR83_RS19010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HZR83_RS19015	COG1286	toxin biosynthetic process
HZR83_RS19020	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HZR83_RS19025	COG0285	dihydrofolate synthase activity
HZR83_RS19035	COG0586	Pfam SNARE associated Golgi protein
HZR83_RS19045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZR83_RS19060	COG2814	Major facilitator Superfamily
HZR83_RS19065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZR83_RS19080	COG3101	peptidyl-lysine hydroxylation
HZR83_RS19085	COG0730	response to heat
HZR83_RS19100	COG2890	protein-(glutamine-N5) methyltransferase activity
HZR83_RS19115	COG3539	Fimbrial protein
HZR83_RS19120	COG3539	Fimbrial protein
HZR83_RS19125	COG3539	Fimbrial protein
HZR83_RS19130	COG3121	Chaperone
HZR83_RS19135	COG3188	usher protein
HZR83_RS19140	COG3539	Fimbrial protein
HZR83_RS19145	COG2062	phosphohistidine phosphatase, SixA
HZR83_RS19160	COG3691	Protein conserved in bacteria
HZR83_RS19165	COG2067	long-chain fatty acid transport protein
HZR83_RS19175	COG2853	Lipoprotein
HZR83_RS19180	COG2116	formate transmembrane transporter activity
HZR83_RS19190	COG0582	viral genome integration into host DNA
HZR83_RS19280	COG0477	Major facilitator Superfamily
HZR83_RS19285	COG1566	PFAM secretion protein HlyD family protein
HZR83_RS19290	COG2197	response regulator
HZR83_RS19295	COG0784	Response regulator, receiver
HZR83_RS19295	COG2205	protein histidine kinase activity
HZR83_RS19295	COG2198	Histidine kinase
HZR83_RS19295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZR83_RS19300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZR83_RS19305	COG0679	Auxin Efflux Carrier
HZR83_RS19310	COG0028	Belongs to the TPP enzyme family
HZR83_RS19335	COG1560	Kdo2-lipid A biosynthetic process
HZR83_RS19345	COG0436	Aminotransferase
HZR83_RS19350	COG3275	phosphorelay sensor kinase activity
HZR83_RS19355	COG3279	Response regulator of the LytR AlgR family
HZR83_RS19360	COG2207	Transcriptional regulator
HZR83_RS19365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZR83_RS19365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS19365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS19370	COG1363	Peptidase, m42
HZR83_RS19375	COG0006	proline dipeptidase activity
HZR83_RS19380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS19385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZR83_RS19410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZR83_RS19415	COG2199	diguanylate cyclase activity
HZR83_RS19415	COG2200	EAL domain
HZR83_RS19430	COG3415	Transposase
HZR83_RS19435	COG3415	Transposase
HZR83_RS19470	COG0583	DNA-binding transcription factor activity
HZR83_RS19480	COG2211	Major facilitator Superfamily
HZR83_RS19485	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZR83_RS19495	COG0583	DNA-binding transcription factor activity
HZR83_RS19500	COG0385	Bile acid
HZR83_RS19505	COG3530	Putative quorum-sensing-regulated virulence factor
HZR83_RS19525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZR83_RS19530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS19535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZR83_RS19540	COG2190	(PTS) system
HZR83_RS19555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZR83_RS19560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HZR83_RS19565	COG4208	sulfate ABC transporter
HZR83_RS19570	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HZR83_RS19575	COG4150	thiosulfate binding
HZR83_RS19580	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS19595	COG1263	PTS System
HZR83_RS19595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS19600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZR83_RS19610	COG2837	iron assimilation
HZR83_RS19630	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZR83_RS19640	COG2207	Transcriptional regulator
HZR83_RS19645	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HZR83_RS19650	COG4816	utilization protein
HZR83_RS19660	COG4303	Ethanolamine ammonia lyase large subunit
HZR83_RS19665	COG4819	ethanolamine utilization protein
HZR83_RS19670	COG3192	ethanolamine utilization protein
HZR83_RS19675	COG1454	alcohol dehydrogenase
HZR83_RS19680	COG4820	ethanolamine utilization protein (EutJ)
HZR83_RS19685	COG1012	belongs to the aldehyde dehydrogenase family
HZR83_RS19690	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HZR83_RS19695	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HZR83_RS19700	COG0280	phosphate acetyltransferase
HZR83_RS19705	COG4812	Cobalamin adenosyltransferase
HZR83_RS19710	COG4766	ethanolamine catabolic process
HZR83_RS19715	COG4917	ethanolamine utilization protein
HZR83_RS19720	COG4810	utilization protein
HZR83_RS19725	COG0280	phosphate acetyltransferase
HZR83_RS19725	COG0281	malic enzyme
HZR83_RS19730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZR83_RS19735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZR83_RS19740	COG5342	invasion associated locus B
HZR83_RS19750	COG0493	'glutamate synthase
HZR83_RS19750	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZR83_RS19755	COG3850	Histidine kinase
HZR83_RS19760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZR83_RS19770	COG1393	Belongs to the ArsC family
HZR83_RS19785	COG0400	carboxylic ester hydrolase activity
HZR83_RS19795	COG2321	neutral zinc metallopeptidase
HZR83_RS19805	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HZR83_RS19815	COG2716	regulation of RNA biosynthetic process
HZR83_RS19820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZR83_RS19825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZR83_RS19830	COG0651	ATP synthesis coupled electron transport
HZR83_RS19835	COG0650	Formate hydrogenlyase subunit 4
HZR83_RS19840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HZR83_RS19845	COG4237	Hydrogenase 4 membrane
HZR83_RS19850	COG0651	ATP synthesis coupled electron transport
HZR83_RS19855	COG3261	NADH dehydrogenase
HZR83_RS19855	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HZR83_RS19860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZR83_RS19865	COG3260	NADH ubiquinone oxidoreductase 20
HZR83_RS19875	COG3604	Transcriptional regulator
HZR83_RS19880	COG2116	formate transmembrane transporter activity
HZR83_RS19885	COG0628	permease
HZR83_RS19890	COG4783	chaperone-mediated protein folding
HZR83_RS19895	COG1393	Belongs to the ArsC family
HZR83_RS19905	COG2233	PERMEase
HZR83_RS19920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZR83_RS19925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZR83_RS19930	COG0248	Ppx GppA phosphatase
HZR83_RS19935	COG2200	EAL domain
HZR83_RS19950	COG3133	Outer membrane lipoprotein
HZR83_RS19965	COG0517	IMP dehydrogenase activity
HZR83_RS19965	COG0516	GMP reductase activity
HZR83_RS19990	COG1645	bacterial-type flagellum-dependent swarming motility
HZR83_RS20005	COG2976	Protein conserved in bacteria
HZR83_RS20035	COG4953	penicillin-binding protein 1C
HZR83_RS20040	COG2373	Large extracellular alpha-helical protein
HZR83_RS20045	COG2897	thiosulfate sulfurtransferase activity
HZR83_RS20060	COG2975	iron-sulfur cluster assembly
HZR83_RS20065	COG0633	Ferredoxin
HZR83_RS20085	COG0822	iron-sulfur transferase activity
HZR83_RS20105	COG0483	inositol monophosphate 1-phosphatase activity
HZR83_RS20110	COG1073	alpha beta
HZR83_RS20115	COG3711	transcriptional antiterminator
HZR83_RS20120	COG2814	Major facilitator Superfamily
HZR83_RS20125	COG0583	DNA-binding transcription factor activity
HZR83_RS20130	COG4638	Rieske (2fe-2S)
HZR83_RS20155	COG2259	Doxx family
HZR83_RS20160	COG2017	converts alpha-aldose to the beta-anomer
HZR83_RS20165	COG1063	alcohol dehydrogenase
HZR83_RS20170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZR83_RS20175	COG1129	ABC transporter
HZR83_RS20180	COG1879	ABC-type sugar transport system periplasmic component
HZR83_RS20185	COG0457	Tetratricopeptide repeat
HZR83_RS20190	COG1940	carbohydrate kinase activity
HZR83_RS20200	COG1017	nitric oxide dioxygenase activity
HZR83_RS20200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HZR83_RS20205	COG0347	Belongs to the P(II) protein family
HZR83_RS20210	COG2204	response regulator
HZR83_RS20215	COG3170	Tfp pilus assembly protein FimV
HZR83_RS20220	COG2205	protein histidine kinase activity
HZR83_RS20225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZR83_RS20225	COG0047	phosphoribosylformylglycinamidine synthase activity
HZR83_RS20240	COG0560	Phosphoserine phosphatase
HZR83_RS20245	COG1737	Transcriptional regulator
HZR83_RS20250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZR83_RS20265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HZR83_RS20285	COG0681	Belongs to the peptidase S26 family
HZR83_RS20295	COG3086	response to oxidative stress
HZR83_RS20300	COG3026	antisigma factor binding
HZR83_RS20305	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HZR83_RS20310	COG1595	DNA-templated transcription, initiation
HZR83_RS20320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HZR83_RS20330	COG0513	Belongs to the DEAD box helicase family
HZR83_RS20335	COG0583	DNA-binding transcription factor activity
HZR83_RS20355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZR83_RS20360	COG3118	belongs to the thioredoxin family
HZR83_RS20370	COG0045	succinate-CoA ligase (ADP-forming) activity
HZR83_RS20370	COG1042	CoA-binding domain protein
HZR83_RS20370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HZR83_RS20375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HZR83_RS20380	COG5544	Lipoprotein
HZR83_RS20385	COG0477	Major facilitator Superfamily
HZR83_RS20415	COG0542	response to heat
HZR83_RS20425	COG0564	pseudouridine synthase activity
HZR83_RS20430	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZR83_RS20435	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HZR83_RS20445	COG0077	Prephenate dehydratase
HZR83_RS20445	COG1605	Chorismate mutase
HZR83_RS20450	COG0287	Prephenate dehydrogenase
HZR83_RS20450	COG1605	Chorismate mutase
HZR83_RS20455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HZR83_RS20470	COG2199	diguanylate cyclase activity
HZR83_RS20475	COG2885	chlorophyll binding
HZR83_RS20500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZR83_RS20505	COG4137	Cytochrome C assembly protein
HZR83_RS20510	COG4536	flavin adenine dinucleotide binding
HZR83_RS20525	COG0497	DNA recombination
HZR83_RS20530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZR83_RS20540	COG2867	negative regulation of translational initiation
HZR83_RS20555	COG0582	viral genome integration into host DNA
HZR83_RS20640	COG0366	Alpha amylase catalytic
HZR83_RS20650	COG0579	oxidoreductase
HZR83_RS20655	COG1012	belongs to the aldehyde dehydrogenase family
HZR83_RS20660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HZR83_RS20665	COG1113	amino acid transport
HZR83_RS20670	COG1802	Transcriptional regulator
HZR83_RS20675	COG1652	LysM domain
HZR83_RS20680	COG0401	homolog of Blt101
HZR83_RS20685	COG0640	Transcriptional regulator
HZR83_RS20690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZR83_RS20695	COG2916	Histone family protein nucleoid-structuring protein H-NS
HZR83_RS20715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HZR83_RS20725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZR83_RS20730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZR83_RS20735	COG4175	Glycine betaine
HZR83_RS20740	COG4176	ABC-type proline glycine betaine transport system permease component
HZR83_RS20745	COG2113	Glycine betaine
HZR83_RS20750	COG2814	Major facilitator Superfamily
HZR83_RS20755	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HZR83_RS20765	COG1846	Transcriptional regulator
HZR83_RS20770	COG1566	PFAM secretion protein HlyD family protein
HZR83_RS20775	COG2814	Major facilitator Superfamily
HZR83_RS20790	COG1238	metal cluster binding
HZR83_RS20795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HZR83_RS20825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HZR83_RS20845	COG1546	Belongs to the CinA family
HZR83_RS20850	COG2951	lytic endotransglycosylase activity
HZR83_RS20855	COG3730	PTS system glucitol sorbitol-specific
HZR83_RS20860	COG3732	PTS system glucitol sorbitol-specific
HZR83_RS20870	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS20875	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS20880	COG1349	DNA-binding transcription factor activity
HZR83_RS20905	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HZR83_RS20910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZR83_RS20915	COG1609	Transcriptional regulator
HZR83_RS20920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS20920	COG1263	PTS System
HZR83_RS20925	COG2723	6-phospho-beta-galactosidase activity
HZR83_RS20930	COG5499	transcription regulator containing HTH domain
HZR83_RS20935	COG4680	protein conserved in bacteria
HZR83_RS20940	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZR83_RS20950	COG3260	NADH ubiquinone oxidoreductase 20
HZR83_RS20955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZR83_RS20960	COG3261	NADH dehydrogenase
HZR83_RS20960	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HZR83_RS20965	COG0650	Formate hydrogenlyase subunit 4
HZR83_RS20970	COG0651	ATP synthesis coupled electron transport
HZR83_RS20975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZR83_RS20985	COG0375	protein maturation
HZR83_RS20990	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HZR83_RS20995	COG0298	carbon dioxide binding
HZR83_RS21000	COG0409	Hydrogenase expression formation protein
HZR83_RS21005	COG0309	Hydrogenase expression formation protein (HypE)
HZR83_RS21010	COG3604	Transcriptional regulator
HZR83_RS21035	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HZR83_RS21040	COG1349	DNA-binding transcription factor activity
HZR83_RS21045	COG2084	Dehydrogenase
HZR83_RS21050	COG3395	kinase activity
HZR83_RS21055	COG0235	Class ii aldolase
HZR83_RS21060	COG3622	Belongs to the hyi family
HZR83_RS21065	COG2610	gluconate transmembrane transporter activity
HZR83_RS21075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HZR83_RS21080	COG0163	prenyltransferase activity
HZR83_RS21090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZR83_RS21095	COG1388	LysM domain
HZR83_RS21095	COG4942	peptidase
HZR83_RS21150	COG2234	aminopeptidase activity
HZR83_RS21155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZR83_RS21160	COG1518	maintenance of DNA repeat elements
HZR83_RS21175	COG1857	crispr-associated protein
HZR83_RS21190	COG1203	CRISPR-associated helicase, Cas3
HZR83_RS21195	COG3385	transposase activity
HZR83_RS21220	COG0720	synthase
HZR83_RS21225	COG0644	oxidoreductase
HZR83_RS21230	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HZR83_RS21235	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HZR83_RS21245	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HZR83_RS21250	COG2086	electron transfer activity
HZR83_RS21255	COG0477	Major facilitator Superfamily
HZR83_RS21260	COG0277	FAD linked oxidase domain protein
HZR83_RS21265	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS21270	COG2223	nitrite transmembrane transporter activity
HZR83_RS21275	COG1070	Carbohydrate kinase
HZR83_RS21280	COG0602	queuosine metabolic process
HZR83_RS21290	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HZR83_RS21305	COG3956	TIGRFAM MazG family protein
HZR83_RS21310	COG2337	Toxic component of a toxin-antitoxin (TA) module
HZR83_RS21315	COG2336	PFAM SpoVT AbrB
HZR83_RS21320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZR83_RS21330	COG3437	response regulator, receiver
HZR83_RS21330	COG4999	Histidine kinase
HZR83_RS21330	COG2205	protein histidine kinase activity
HZR83_RS21330	COG3850	Histidine kinase
HZR83_RS21335	COG4948	Mandelate Racemase Muconate Lactonizing
HZR83_RS21340	COG4948	Mandelate Racemase Muconate Lactonizing
HZR83_RS21345	COG2271	Major facilitator Superfamily
HZR83_RS21350	COG0716	FMN binding
HZR83_RS21355	COG0564	pseudouridine synthase activity
HZR83_RS21360	COG3098	single-species biofilm formation
HZR83_RS21375	COG1611	Belongs to the LOG family
HZR83_RS21380	COG0814	amino acid
HZR83_RS21385	COG1760	l-serine dehydratase
HZR83_RS21395	COG1454	alcohol dehydrogenase
HZR83_RS21400	COG0235	Class ii aldolase
HZR83_RS21410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZR83_RS21415	COG1609	Transcriptional regulator
HZR83_RS21420	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZR83_RS21425	COG1129	ABC transporter
HZR83_RS21435	COG1070	Carbohydrate kinase
HZR83_RS21445	COG1349	DNA-binding transcription factor activity
HZR83_RS21455	COG2363	Small membrane protein
HZR83_RS21460	COG0583	DNA-binding transcription factor activity
HZR83_RS21470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZR83_RS21475	COG2166	iron-sulfur cluster assembly
HZR83_RS21480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZR83_RS21485	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HZR83_RS21515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZR83_RS21520	COG1263	PTS System
HZR83_RS21520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS21525	COG3711	transcriptional antiterminator
HZR83_RS21530	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZR83_RS21535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HZR83_RS21535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZR83_RS21540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZR83_RS21545	COG1074	ATP-dependent DNA helicase activity
HZR83_RS21555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HZR83_RS21560	COG4967	type IV pilus modification protein PilV
HZR83_RS21570	COG4795	General secretion pathway protein
HZR83_RS21575	COG2165	general secretion pathway protein
HZR83_RS21590	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HZR83_RS21605	COG0861	Integral membrane protein TerC family
HZR83_RS21615	COG0667	Aldo Keto reductase
HZR83_RS21630	COG1609	Transcriptional regulator
HZR83_RS21640	COG0583	DNA-binding transcription factor activity
HZR83_RS21645	COG1794	racemase activity, acting on amino acids and derivatives
HZR83_RS21650	COG2814	Major facilitator Superfamily
HZR83_RS21655	COG1028	Short-chain dehydrogenase reductase Sdr
HZR83_RS21665	COG0183	Belongs to the thiolase family
HZR83_RS21670	COG0814	amino acid
HZR83_RS21675	COG2771	luxR family
HZR83_RS21680	COG3710	Transcriptional regulator
HZR83_RS21705	COG0457	Tetratricopeptide repeat
HZR83_RS21710	COG3710	Transcriptional regulator
HZR83_RS21710	COG0457	Tetratricopeptide repeat
HZR83_RS21720	COG0741	lytic transglycosylase activity
HZR83_RS21725	COG2197	response regulator
HZR83_RS21825	COG2207	Transcriptional regulator
HZR83_RS21835	COG3387	PFAM Glycoside hydrolase 15-related
HZR83_RS21845	COG4942	peptidase
HZR83_RS21850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZR83_RS21855	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZR83_RS21860	COG2080	2 iron, 2 sulfur cluster binding
HZR83_RS21870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZR83_RS21875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZR83_RS21880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZR83_RS21890	COG0549	Belongs to the carbamate kinase family
HZR83_RS21895	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZR83_RS21895	COG3608	succinylglutamate desuccinylase aspartoacylase
HZR83_RS21900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZR83_RS21905	COG2068	MobA-Related Protein
HZR83_RS21910	COG0493	'glutamate synthase
HZR83_RS21910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZR83_RS21915	COG0402	S-adenosylhomocysteine deaminase activity
HZR83_RS21920	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HZR83_RS21925	COG2080	2 iron, 2 sulfur cluster binding
HZR83_RS21925	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZR83_RS21930	COG2233	PERMEase
HZR83_RS21935	COG0402	S-adenosylhomocysteine deaminase activity
HZR83_RS21940	COG2252	PERMEase
HZR83_RS21945	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZR83_RS21955	COG2233	PERMEase
HZR83_RS21975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZR83_RS21985	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZR83_RS21990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZR83_RS21995	COG4974	Belongs to the 'phage' integrase family
HZR83_RS22000	COG0716	FMN binding
HZR83_RS22010	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HZR83_RS22020	COG1272	protein, Hemolysin III
HZR83_RS22030	COG2723	6-phospho-beta-galactosidase activity
HZR83_RS22055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZR83_RS22060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZR83_RS22065	COG0006	proline dipeptidase activity
HZR83_RS22085	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HZR83_RS22095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZR83_RS22115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZR83_RS22115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZR83_RS22120	COG1703	isobutyryl-CoA mutase activity
HZR83_RS22125	COG1024	Enoyl-CoA hydratase
HZR83_RS22130	COG0427	acetyl-CoA hydrolase
HZR83_RS22135	COG0583	DNA-binding transcription factor activity
HZR83_RS22140	COG2968	Membrane
HZR83_RS22145	COG1279	arginine transmembrane transporter activity
HZR83_RS22150	COG0668	transmembrane transport
HZR83_RS22155	COG0191	fructose-bisphosphate aldolase activity
HZR83_RS22170	COG1072	(Pantothenic acid kinase))
HZR83_RS22175	COG3722	fumarate hydratase activity
HZR83_RS22180	COG1494	fructose-1,6-bisphosphatase
HZR83_RS22185	COG1063	alcohol dehydrogenase
HZR83_RS22190	COG2213	PTS system mannitol-specific
HZR83_RS22195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS22200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HZR83_RS22205	COG0501	Belongs to the peptidase M48B family
HZR83_RS22215	COG1166	arginine decarboxylase activity
HZR83_RS22235	COG2814	Major facilitator Superfamily
HZR83_RS22245	COG2356	endonuclease I
HZR83_RS22250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZR83_RS22255	COG0189	ligase activity
HZR83_RS22270	COG2805	Type II/IV secretion system protein
HZR83_RS22275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZR83_RS22280	COG0762	integral membrane protein
HZR83_RS22290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZR83_RS22295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZR83_RS22305	COG0252	asparaginase activity
HZR83_RS22315	COG3171	Protein conserved in bacteria
HZR83_RS22325	COG1194	a g-specific adenine glycosylase
HZR83_RS22340	COG2211	Major facilitator Superfamily
HZR83_RS22345	COG1982	Orn Lys Arg decarboxylase major
HZR83_RS22350	COG1811	Na channel or pump
HZR83_RS22575	COG4771	TonB-dependent receptor
HZR83_RS22580	COG2814	Major facilitator Superfamily
HZR83_RS22590	COG3433	isochorismatase activity
HZR83_RS22590	COG2226	methyltransferase
HZR83_RS22590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZR83_RS22610	COG1132	(ABC) transporter
HZR83_RS22680	COG3059	membrane
HZR83_RS22705	COG1982	Orn Lys Arg decarboxylase major
HZR83_RS22730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZR83_RS22770	COG0305	Participates in initiation and elongation during chromosome replication
HZR83_RS22800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZR83_RS22805	COG2854	intermembrane phospholipid transfer
HZR83_RS22810	COG3113	response to antibiotic
HZR83_RS22815	COG5007	Belongs to the BolA IbaG family
HZR83_RS22825	COG3423	Transcriptional regulator
HZR83_RS22830	COG0142	geranyltranstransferase activity
HZR83_RS22845	COG0697	spore germination
HZR83_RS22855	COG2027	D-alanyl-D-alanine carboxypeptidase
HZR83_RS22860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZR83_RS22865	COG1534	Rna-binding protein
HZR83_RS22875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZR83_RS22880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZR83_RS22890	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZR83_RS22900	COG2194	sulfuric ester hydrolase activity
HZR83_RS22920	COG0195	Participates in both transcription termination and antitermination
HZR83_RS22960	COG0513	Belongs to the DEAD box helicase family
HZR83_RS22965	COG0814	amino acid
HZR83_RS22970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZR83_RS22975	COG0826	peptidase U32
HZR83_RS22980	COG0826	peptidase U32
HZR83_RS22985	COG3154	lipid carrier protein
HZR83_RS22990	COG3153	acetyltransferase
HZR83_RS23005	COG0693	protein deglycase activity
HZR83_RS23010	COG0702	epimerase
HZR83_RS23015	COG0701	Predicted permease
HZR83_RS23020	COG2823	Periplasmic or secreted lipoprotein
HZR83_RS23040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HZR83_RS23045	COG0363	glucosamine-6-phosphate deaminase activity
HZR83_RS23050	COG3716	PTS system mannose fructose sorbose family IID component
HZR83_RS23055	COG3715	PTS system
HZR83_RS23060	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS23070	COG2222	sugar isomerase
HZR83_RS23075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HZR83_RS23080	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZR83_RS23085	COG3716	PTS system mannose fructose sorbose family IID component
HZR83_RS23095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZR83_RS23105	COG1349	DNA-binding transcription factor activity
HZR83_RS23115	COG2002	toxin-antitoxin pair type II binding
HZR83_RS23120	COG2721	sulfolactate sulfo-lyase activity
HZR83_RS23125	COG2271	Major facilitator Superfamily
HZR83_RS23135	COG2084	Dehydrogenase
HZR83_RS23140	COG1929	Belongs to the glycerate kinase type-1 family
HZR83_RS23165	COG0583	DNA-binding transcription factor activity
HZR83_RS23170	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZR83_RS23180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HZR83_RS23185	COG1882	Formate acetyltransferase
HZR83_RS23190	COG0251	oxidation-reduction process
HZR83_RS23195	COG1760	l-serine dehydratase
HZR83_RS23200	COG0814	amino acid
HZR83_RS23215	COG1741	Belongs to the pirin family
HZR83_RS23220	COG0583	DNA-binding transcription factor activity
HZR83_RS23225	COG3152	Membrane
HZR83_RS23255	COG1192	Involved in chromosome partitioning
HZR83_RS23500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZR83_RS23515	COG0741	lytic transglycosylase activity
HZR83_RS23675	COG4771	TonB-dependent receptor
HZR83_RS23705	COG3436	PFAM IS66 Orf2 family protein
HZR83_RS23720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZR83_RS23760	COG0640	Transcriptional regulator
HZR83_RS23795	COG3173	Aminoglycoside phosphotransferase
HZR83_RS23875	COG1660	Displays ATPase and GTPase activities
HZR83_RS23920	COG4644	lycopene metabolic process
HZR83_RS23980	COG3436	PFAM IS66 Orf2 family protein
HZR83_RS24000	COG1288	antiporter activity
HZR83_RS24015	COG2235	arginine
HZR83_RS24055	COG4372	Transposase
HZR83_RS24060	COG3436	PFAM IS66 Orf2 family protein
HZR83_RS24470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZR83_RS24485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZR83_RS24490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZR83_RS24495	COG1121	(ABC) transporter
HZR83_RS24525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZR83_RS24585	COG3039	Transposase
HZR83_RS24610	COG0673	inositol 2-dehydrogenase activity
HZR83_RS24615	COG1324	tolerance protein
HZR83_RS24650	COG1349	DNA-binding transcription factor activity
HZR83_RS24680	COG1192	Involved in chromosome partitioning
HZR83_RS24725	COG0484	heat shock protein binding
HZR83_RS24840	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HZR83_RS24870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins