locus-tag	class	description
A1D75_RS00010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A1D75_RS00020	COG0534	Mate efflux family protein
A1D75_RS00025	COG3237	CsbD-like
A1D75_RS00030	COG0735	belongs to the Fur family
A1D75_RS00040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A1D75_RS00050	COG0604	alcohol dehydrogenase
A1D75_RS00055	COG0305	Participates in initiation and elongation during chromosome replication
A1D75_RS00060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A1D75_RS00065	COG1448	Aminotransferase
A1D75_RS00075	COG3700	Belongs to the class B bacterial acid phosphatase family
A1D75_RS00080	COG0432	Pfam Uncharacterised protein family UPF0047
A1D75_RS00085	COG2315	Protein conserved in bacteria
A1D75_RS00090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A1D75_RS00095	COG0629	single-stranded DNA binding
A1D75_RS00105	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A1D75_RS00110	COG2207	Transcriptional regulator
A1D75_RS00115	COG0789	Transcriptional regulator
A1D75_RS00120	COG2252	PERMEase
A1D75_RS00125	COG0025	NhaP-type Na H and K H
A1D75_RS00130	COG1357	PFAM Pentapeptide repeats (8 copies)
A1D75_RS00140	COG3162	membrane
A1D75_RS00145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A1D75_RS00155	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A1D75_RS00160	COG0437	4 iron, 4 sulfur cluster binding
A1D75_RS00165	COG3301	Polysulphide reductase, NrfD
A1D75_RS00170	COG1138	Cytochrome C-type biogenesis protein
A1D75_RS00175	COG3088	subunit of a heme lyase
A1D75_RS00180	COG4235	cytochrome complex assembly
A1D75_RS00185	COG1301	dicarboxylic acid transport
A1D75_RS00190	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A1D75_RS00200	COG1538	Outer membrane efflux protein
A1D75_RS00205	COG1289	transmembrane transporter activity
A1D75_RS00210	COG1566	PFAM secretion protein HlyD family protein
A1D75_RS00220	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A1D75_RS00230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1D75_RS00250	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS00255	COG1129	ABC transporter
A1D75_RS00275	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A1D75_RS00280	COG0456	acetyltransferase
A1D75_RS00285	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A1D75_RS00290	COG3454	Phosphonate metabolism
A1D75_RS00295	COG4778	phosphonate C-P lyase system protein PhnL
A1D75_RS00300	COG4107	phosphonate C-P lyase system protein PhnK
A1D75_RS00305	COG3627	carbon phosphorus lyase activity
A1D75_RS00310	COG3626	phosphonate metabolism
A1D75_RS00315	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
A1D75_RS00320	COG3624	Phosphonate C-P lyase system protein PhnG
A1D75_RS00325	COG2188	Transcriptional regulator
A1D75_RS00330	COG3639	organic phosphonate transmembrane transporter activity
A1D75_RS00335	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
A1D75_RS00340	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A1D75_RS00345	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A1D75_RS00350	COG2824	Alkylphosphonate utilization operon protein PhnA
A1D75_RS00355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A1D75_RS00365	COG0477	Major facilitator Superfamily
A1D75_RS00375	COG0642	Histidine kinase
A1D75_RS00380	COG0745	RESPONSE REGULATOR receiver
A1D75_RS00385	COG2194	sulfuric ester hydrolase activity
A1D75_RS00390	COG0531	amino acid
A1D75_RS00395	COG2207	Transcriptional regulator
A1D75_RS00400	COG1982	Orn Lys Arg decarboxylase major
A1D75_RS00405	COG2169	Transcriptional regulator
A1D75_RS00410	COG1486	melibiose metabolic process
A1D75_RS00415	COG2211	Major facilitator Superfamily
A1D75_RS00425	COG3647	Membrane
A1D75_RS00430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A1D75_RS00430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A1D75_RS00435	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A1D75_RS00445	COG4565	transcriptional regulatory protein
A1D75_RS00450	COG3290	protein histidine kinase activity
A1D75_RS00455	COG3592	Divergent 4Fe-4S mono-cluster
A1D75_RS00460	COG2388	GCN5-related N-acetyl-transferase
A1D75_RS00475	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A1D75_RS00480	COG3104	oligopeptide transport
A1D75_RS00485	COG1982	Orn Lys Arg decarboxylase major
A1D75_RS00490	COG0531	amino acid
A1D75_RS00500	COG3710	Transcriptional regulator
A1D75_RS00510	COG1309	transcriptional regulator
A1D75_RS00515	COG4232	protein-disulfide reductase activity
A1D75_RS00525	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A1D75_RS00530	COG1027	Aspartate ammonia-lyase
A1D75_RS00535	COG3030	protein affecting phage T7 exclusion by the F plasmid
A1D75_RS00540	COG0531	amino acid
A1D75_RS00565	COG1509	lysine 2,3-aminomutase activity
A1D75_RS00575	COG5510	response to toxic substance
A1D75_RS00580	COG5510	response to toxic substance
A1D75_RS00585	COG2076	Multidrug Resistance protein
A1D75_RS00590	COG3040	lipid binding
A1D75_RS00595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A1D75_RS00610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A1D75_RS00615	COG1053	succinate dehydrogenase
A1D75_RS00625	COG0531	amino acid
A1D75_RS00630	COG1511	domain protein
A1D75_RS00630	COG3264	Mechanosensitive ion channel
A1D75_RS00645	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A1D75_RS00670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A1D75_RS00670	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A1D75_RS00675	COG0802	atpase or kinase
A1D75_RS00680	COG0860	N-Acetylmuramoyl-L-alanine amidase
A1D75_RS00685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A1D75_RS00700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A1D75_RS00705	COG0330	HflC and HflK could
A1D75_RS00710	COG0330	HflC and HflK could
A1D75_RS00715	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A1D75_RS00730	COG0557	exoribonuclease II activity
A1D75_RS00735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1D75_RS00740	COG3789	protein conserved in bacteria
A1D75_RS00745	COG1842	Phage shock protein A
A1D75_RS00755	COG3766	membrane
A1D75_RS00760	COG5463	Belongs to the UPF0441 family
A1D75_RS00765	COG0754	glutathionylspermidine amidase activity
A1D75_RS00770	COG1960	acyl-CoA dehydrogenase activity
A1D75_RS00780	COG3650	response to hydrogen peroxide
A1D75_RS00785	COG1073	alpha beta
A1D75_RS00800	COG3037	sugar-specific permease SgaT UlaA
A1D75_RS00805	COG3414	Phosphotransferase system galactitol-specific IIB component
A1D75_RS00810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS00845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A1D75_RS00870	COG0675	Transposase, IS605 OrfB family
A1D75_RS00880	COG3061	Opacity-associated protein A
A1D75_RS00885	COG0545	Peptidyl-prolyl cis-trans isomerase
A1D75_RS00890	COG1113	amino acid transport
A1D75_RS00900	COG0697	spore germination
A1D75_RS00905	COG0702	epimerase
A1D75_RS00910	COG1733	regulation of RNA biosynthetic process
A1D75_RS00915	COG0737	Belongs to the 5'-nucleotidase family
A1D75_RS00920	COG1218	3'(2'),5'-bisphosphate nucleotidase
A1D75_RS00930	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A1D75_RS00940	COG1253	flavin adenine dinucleotide binding
A1D75_RS00950	COG0729	surface antigen
A1D75_RS00955	COG2911	Protein conserved in bacteria
A1D75_RS00960	COG2105	PFAM AIG2 family protein
A1D75_RS00965	COG2336	PFAM SpoVT AbrB
A1D75_RS00970	COG2337	Toxic component of a toxin-antitoxin (TA) module
A1D75_RS00975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A1D75_RS00980	COG1879	ABC-type sugar transport system periplasmic component
A1D75_RS00985	COG1129	ABC transporter
A1D75_RS00990	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS00995	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS01005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A1D75_RS01015	COG0312	modulator of DNA gyrase
A1D75_RS01020	COG3783	Cytochrome b(562)
A1D75_RS01025	COG0602	queuosine metabolic process
A1D75_RS01030	COG1328	CTP reductase activity
A1D75_RS01035	COG0366	Alpha amylase catalytic
A1D75_RS01040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1D75_RS01040	COG1263	PTS System
A1D75_RS01045	COG1609	Transcriptional regulator
A1D75_RS01055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A1D75_RS01060	COG0251	oxidation-reduction process
A1D75_RS01080	COG0251	oxidation-reduction process
A1D75_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS01090	COG1309	transcriptional regulator
A1D75_RS01095	COG2731	YhcH YjgK YiaL family protein
A1D75_RS01105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A1D75_RS01110	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A1D75_RS01115	COG0456	acetyltransferase
A1D75_RS01120	COG4269	membrane
A1D75_RS01130	COG2927	DNA polymerase III (CHI subunit)
A1D75_RS01140	COG0795	lipopolysaccharide-transporting ATPase activity
A1D75_RS01145	COG0795	lipopolysaccharide-transporting ATPase activity
A1D75_RS01150	COG0433	COG0433 Predicted ATPase
A1D75_RS01155	COG1064	alcohol dehydrogenase
A1D75_RS01215	COG0582	viral genome integration into host DNA
A1D75_RS01260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A1D75_RS01270	COG1111	helicase
A1D75_RS01270	COG1205	dead DEAH box helicase
A1D75_RS01275	COG0210	DNA helicase
A1D75_RS01290	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
A1D75_RS01295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A1D75_RS01300	COG0582	viral genome integration into host DNA
A1D75_RS01305	COG4974	Belongs to the 'phage' integrase family
A1D75_RS01310	COG3539	Fimbrial protein
A1D75_RS01315	COG3539	Fimbrial protein
A1D75_RS01320	COG3121	Chaperone
A1D75_RS01325	COG3188	usher protein
A1D75_RS01330	COG3539	Fimbrial protein
A1D75_RS01335	COG3539	Fimbrial protein
A1D75_RS01340	COG3539	Fimbrial protein
A1D75_RS01345	COG2610	gluconate transmembrane transporter activity
A1D75_RS01355	COG0246	Mannitol dehydrogenase
A1D75_RS01360	COG2186	Transcriptional regulator
A1D75_RS01385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A1D75_RS01390	COG0700	Nucleoside recognition
A1D75_RS01395	COG3366	ferrous iron transmembrane transporter activity
A1D75_RS01405	COG1470	cell adhesion involved in biofilm formation
A1D75_RS01405	COG1388	LysM domain
A1D75_RS01410	COG2373	Large extracellular alpha-helical protein
A1D75_RS01410	COG1388	LysM domain
A1D75_RS01410	COG4932	domain protein
A1D75_RS01415	COG0477	Major facilitator Superfamily
A1D75_RS01420	COG3204	pilus organization
A1D75_RS01440	COG1924	4 iron, 4 sulfur cluster binding
A1D75_RS01445	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
A1D75_RS01450	COG2733	membrane
A1D75_RS01455	COG2814	Major facilitator Superfamily
A1D75_RS01465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1D75_RS01470	COG5457	Domain of unknown function (DUF1127)
A1D75_RS01490	COG0732	type I restriction modification DNA specificity domain
A1D75_RS01515	COG0523	cobalamin synthesis protein
A1D75_RS01520	COG2879	small protein
A1D75_RS01525	COG1966	Carbon starvation protein
A1D75_RS01535	COG0840	transmembrane signaling receptor activity
A1D75_RS01545	COG1802	Transcriptional regulator
A1D75_RS01550	COG1063	alcohol dehydrogenase
A1D75_RS01565	COG1484	DNA-dependent DNA replication
A1D75_RS01580	COG2966	Psort location CytoplasmicMembrane, score
A1D75_RS01585	COG2197	response regulator
A1D75_RS01590	COG2197	response regulator
A1D75_RS01595	COG4114	ferric iron reductase
A1D75_RS01615	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A1D75_RS01620	COG0456	acetyltransferase
A1D75_RS01625	COG1011	Hydrolase
A1D75_RS01635	COG2823	Periplasmic or secreted lipoprotein
A1D75_RS01645	COG4667	esterase of the alpha-beta hydrolase superfamily
A1D75_RS01650	COG0084	hydrolase, TatD family'
A1D75_RS01655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A1D75_RS01690	COG0095	Lipoate-protein ligase
A1D75_RS01690	COG3726	membrane protein affecting hemolysin expression
A1D75_RS01695	COG0560	Phosphoserine phosphatase
A1D75_RS01700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A1D75_RS01705	COG3172	ATPase kinase involved in NAD metabolism
A1D75_RS01705	COG1056	cytidyltransferase-related domain
A1D75_RS01710	COG0488	(ABC) transporter
A1D75_RS01715	COG0741	lytic transglycosylase activity
A1D75_RS01725	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A1D75_RS01735	COG3708	Transcriptional regulator
A1D75_RS01735	COG2207	Transcriptional regulator
A1D75_RS01740	COG3045	CreA protein
A1D75_RS01745	COG0745	RESPONSE REGULATOR receiver
A1D75_RS01750	COG2205	protein histidine kinase activity
A1D75_RS01755	COG4452	Inner membrane protein CreD
A1D75_RS01760	COG0745	RESPONSE REGULATOR receiver
A1D75_RS01770	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A1D75_RS01780	COG0460	homoserine dehydrogenase
A1D75_RS01780	COG0527	aspartate kinase activity
A1D75_RS01790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A1D75_RS01805	COG1115	amino acid carrier protein
A1D75_RS01810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A1D75_RS01815	COG0521	Mo-molybdopterin cofactor biosynthetic process
A1D75_RS01820	COG1584	GPR1 FUN34 yaaH family protein
A1D75_RS01825	COG4735	regulation of single-species biofilm formation
A1D75_RS01855	COG0583	DNA-binding transcription factor activity
A1D75_RS01865	COG3188	usher protein
A1D75_RS01870	COG3121	Chaperone
A1D75_RS01895	COG0196	riboflavin kinase activity
A1D75_RS01910	COG1047	Peptidyl-prolyl cis-trans
A1D75_RS01930	COG0505	Belongs to the CarA family
A1D75_RS01935	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A1D75_RS01950	COG1024	Enoyl-CoA hydratase
A1D75_RS01985	COG0644	oxidoreductase
A1D75_RS01990	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A1D75_RS01995	COG2271	Major facilitator Superfamily
A1D75_RS02010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A1D75_RS02045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A1D75_RS02050	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A1D75_RS02055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A1D75_RS02060	COG1357	PFAM Pentapeptide repeats (8 copies)
A1D75_RS02070	COG0564	pseudouridine synthase activity
A1D75_RS02080	COG0417	DNA replication proofreading
A1D75_RS02085	COG0235	Class ii aldolase
A1D75_RS02100	COG4977	sequence-specific DNA binding
A1D75_RS02105	COG0586	Pfam SNARE associated Golgi protein
A1D75_RS02110	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A1D75_RS02115	COG1178	ABC-type Fe3 transport system permease component
A1D75_RS02120	COG4143	(ABC) transporter
A1D75_RS02130	COG4533	DNA binding
A1D75_RS02150	COG0473	3-isopropylmalate dehydrogenase activity
A1D75_RS02165	COG0583	DNA-binding transcription factor activity
A1D75_RS02170	COG0028	Belongs to the TPP enzyme family
A1D75_RS02175	COG0440	acetolactate synthase activity
A1D75_RS02185	COG1609	Transcriptional regulator
A1D75_RS02200	COG3116	cell division
A1D75_RS02205	COG0768	penicillin binding
A1D75_RS02210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A1D75_RS02215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A1D75_RS02225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A1D75_RS02230	COG0772	Belongs to the SEDS family
A1D75_RS02245	COG1181	Belongs to the D-alanine--D-alanine ligase family
A1D75_RS02250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A1D75_RS02255	COG0849	cell division
A1D75_RS02260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A1D75_RS02280	COG0494	nUDIX hydrolase
A1D75_RS02295	COG0237	dephospho-CoA kinase activity
A1D75_RS02305	COG1459	type II secretion system
A1D75_RS02310	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A1D75_RS02315	COG4969	Belongs to the N-Me-Phe pilin family
A1D75_RS02320	COG0157	Belongs to the NadC ModD family
A1D75_RS02325	COG3023	N-Acetylmuramoyl-L-alanine amidase
A1D75_RS02330	COG3725	Membrane protein required for beta-lactamase induction
A1D75_RS02335	COG1113	amino acid transport
A1D75_RS02340	COG2186	Transcriptional regulator
A1D75_RS02345	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A1D75_RS02350	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1D75_RS02355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1D75_RS02360	COG3064	Membrane
A1D75_RS02365	COG1049	propionate catabolic process, 2-methylcitrate cycle
A1D75_RS02390	COG2132	Multicopper oxidase
A1D75_RS02395	COG4993	Dehydrogenase
A1D75_RS02400	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A1D75_RS02405	COG0288	reversible hydration of carbon dioxide
A1D75_RS02410	COG1131	(ABC) transporter
A1D75_RS02415	COG0842	Transport permease protein
A1D75_RS02420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS02425	COG0726	polysaccharide deacetylase
A1D75_RS02435	COG5464	transposase or invertase
A1D75_RS02460	COG3539	Fimbrial protein
A1D75_RS02465	COG3539	Fimbrial protein
A1D75_RS02470	COG3188	usher protein
A1D75_RS02475	COG3121	Chaperone
A1D75_RS02485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A1D75_RS02490	COG0617	tRNA 3'-terminal CCA addition
A1D75_RS02495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A1D75_RS02500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A1D75_RS02510	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A1D75_RS02515	COG1643	Atp-dependent helicase
A1D75_RS02520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A1D75_RS02525	COG4774	siderophore transport
A1D75_RS02530	COG1120	ATPase activity
A1D75_RS02535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A1D75_RS02540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1D75_RS02565	COG2860	membrane
A1D75_RS02570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A1D75_RS02585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1D75_RS02590	COG3835	regulator
A1D75_RS02610	COG0024	Methionine aminopeptidase
A1D75_RS02635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A1D75_RS02640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A1D75_RS02645	COG0575	Belongs to the CDS family
A1D75_RS02650	COG0750	zinc metalloprotease
A1D75_RS02660	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A1D75_RS02665	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A1D75_RS02690	COG0587	DNA-directed DNA polymerase activity
A1D75_RS02700	COG1982	Orn Lys Arg decarboxylase major
A1D75_RS02705	COG0346	lactoylglutathione lyase activity
A1D75_RS02710	COG0037	tRNA processing
A1D75_RS02715	COG4568	rho-dependent transcription termination
A1D75_RS02730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A1D75_RS02735	COG3015	lipoprotein NlpE involved in copper resistance
A1D75_RS02740	COG0791	NLP P60 protein
A1D75_RS02750	COG1720	tRNA m6t6A37 methyltransferase activity
A1D75_RS02760	COG1464	Belongs to the NlpA lipoprotein family
A1D75_RS02765	COG2011	ABC-type metal ion transport system permease component
A1D75_RS02770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A1D75_RS02775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A1D75_RS02810	COG0656	L-ascorbic acid biosynthetic process
A1D75_RS02815	COG0583	DNA-binding transcription factor activity
A1D75_RS02825	COG2226	methyltransferase
A1D75_RS02830	COG1388	LysM domain
A1D75_RS02830	COG0741	lytic transglycosylase activity
A1D75_RS02840	COG2226	methyltransferase
A1D75_RS02850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1D75_RS02975	COG3209	COG3209 Rhs family protein
A1D75_RS02990	COG5433	transposase activity
A1D75_RS02995	COG3209	COG3209 Rhs family protein
A1D75_RS03010	COG5433	transposase activity
A1D75_RS03015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A1D75_RS03025	COG1960	acyl-CoA dehydrogenase activity
A1D75_RS03035	COG0121	glutamine amidotransferase
A1D75_RS03040	COG3034	peptidoglycan biosynthetic process
A1D75_RS03045	COG3041	Addiction module toxin RelE StbE family
A1D75_RS03050	COG3077	Addiction module antitoxin, RelB DinJ family
A1D75_RS03055	COG0791	NLP P60 protein
A1D75_RS03075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A1D75_RS03080	COG2161	toxin-antitoxin pair type II binding
A1D75_RS03090	COG0454	-acetyltransferase
A1D75_RS03095	COG1690	Belongs to the RtcB family
A1D75_RS03100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A1D75_RS03105	COG2195	Cleaves the N-terminal amino acid of tripeptides
A1D75_RS03125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A1D75_RS03145	COG0582	viral genome integration into host DNA
A1D75_RS03190	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A1D75_RS03205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A1D75_RS03225	COG0582	viral genome integration into host DNA
A1D75_RS03310	COG0583	DNA-binding transcription factor activity
A1D75_RS03315	COG4221	oxidoreductase activity
A1D75_RS03330	COG0583	DNA-binding transcription factor activity
A1D75_RS03345	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A1D75_RS03350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A1D75_RS03355	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A1D75_RS03360	COG2080	2 iron, 2 sulfur cluster binding
A1D75_RS03365	COG3477	response to acidic pH
A1D75_RS03370	COG0727	PFAM Uncharacterised protein family (UPF0153)
A1D75_RS03375	COG3121	Chaperone
A1D75_RS03385	COG3188	usher protein
A1D75_RS03430	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS03435	COG4372	Transposase
A1D75_RS03445	COG1902	pentaerythritol trinitrate reductase activity
A1D75_RS03450	COG1073	alpha beta
A1D75_RS03455	COG0583	DNA-binding transcription factor activity
A1D75_RS03470	COG1388	LysM domain
A1D75_RS03475	COG2207	Transcriptional regulator
A1D75_RS03475	COG3708	Transcriptional regulator
A1D75_RS03480	COG0656	L-ascorbic acid biosynthetic process
A1D75_RS03485	COG3059	membrane
A1D75_RS03495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1D75_RS03500	COG2207	Transcriptional regulator
A1D75_RS03505	COG0247	lactate metabolic process
A1D75_RS03510	COG1139	Iron-sulfur cluster binding protein
A1D75_RS03515	COG1556	Lactate utilization protein
A1D75_RS03545	COG2771	luxR family
A1D75_RS03545	COG2200	EAL domain
A1D75_RS03575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A1D75_RS03585	COG2200	EAL domain
A1D75_RS03585	COG2771	luxR family
A1D75_RS03600	COG0666	response to abiotic stimulus
A1D75_RS03610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A1D75_RS03615	COG1304	FMN binding
A1D75_RS03620	COG0549	Belongs to the carbamate kinase family
A1D75_RS03625	COG0402	S-adenosylhomocysteine deaminase activity
A1D75_RS03635	COG1879	ABC-type sugar transport system periplasmic component
A1D75_RS03640	COG1129	ABC transporter
A1D75_RS03645	COG1129	ABC transporter
A1D75_RS03650	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS03660	COG1064	alcohol dehydrogenase
A1D75_RS03675	COG1280	lysine exporter protein (LysE YggA)
A1D75_RS03685	COG3829	transcription factor binding
A1D75_RS03690	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A1D75_RS03695	COG0372	Belongs to the citrate synthase family
A1D75_RS03700	COG2079	MmgE PrpD family protein
A1D75_RS03705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A1D75_RS03710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A1D75_RS03715	COG0402	S-adenosylhomocysteine deaminase activity
A1D75_RS03720	COG0583	DNA-binding transcription factor activity
A1D75_RS03725	COG0288	reversible hydration of carbon dioxide
A1D75_RS03735	COG2807	transmembrane transport
A1D75_RS03740	COG0110	maltose O-acetyltransferase activity
A1D75_RS03745	COG2223	nitrite transmembrane transporter activity
A1D75_RS03750	COG3250	beta-galactosidase activity
A1D75_RS03755	COG1609	Transcriptional regulator
A1D75_RS03765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A1D75_RS03770	COG1414	Transcriptional regulator
A1D75_RS03785	COG0596	Alpha beta hydrolase
A1D75_RS03800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A1D75_RS03805	COG2814	Major facilitator Superfamily
A1D75_RS03810	COG3122	Protein conserved in bacteria
A1D75_RS03815	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A1D75_RS03830	COG3842	ATPase activity
A1D75_RS03840	COG1840	ABC-type Fe3 transport system, periplasmic component
A1D75_RS03845	COG2271	Major facilitator Superfamily
A1D75_RS03860	COG4521	taurine ABC transporter
A1D75_RS03865	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A1D75_RS03870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A1D75_RS03875	COG2175	clavaminate synthase activity
A1D75_RS03880	COG0113	porphobilinogen synthase activity
A1D75_RS03885	COG3468	outer membrane autotransporter barrel domain protein
A1D75_RS03890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A1D75_RS03895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A1D75_RS03900	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A1D75_RS03920	COG1181	Belongs to the D-alanine--D-alanine ligase family
A1D75_RS03930	COG1785	Belongs to the alkaline phosphatase family
A1D75_RS03940	COG3706	GGDEF domain
A1D75_RS03945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A1D75_RS03965	COG4126	flavin adenine dinucleotide binding
A1D75_RS03990	COG1940	carbohydrate kinase activity
A1D75_RS03995	COG2814	Major facilitator Superfamily
A1D75_RS04000	COG0419	ATPase involved in DNA repair
A1D75_RS04005	COG0420	3'-5' exonuclease activity
A1D75_RS04010	COG0745	RESPONSE REGULATOR receiver
A1D75_RS04015	COG5002	protein histidine kinase activity
A1D75_RS04020	COG1114	Component of the transport system for branched-chain amino acids
A1D75_RS04025	COG1113	amino acid transport
A1D75_RS04030	COG0366	Alpha amylase catalytic
A1D75_RS04055	COG1862	Preprotein translocase
A1D75_RS04060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A1D75_RS04065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A1D75_RS04075	COG3609	addiction module antidote protein, CC2985 family
A1D75_RS04085	COG1403	HNH endonuclease
A1D75_RS04090	COG3248	Nucleoside-binding outer membrane protein
A1D75_RS04095	COG4238	major outer membrane lipoprotein
A1D75_RS04105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A1D75_RS04105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A1D75_RS04120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A1D75_RS04125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A1D75_RS04135	COG0667	Aldo Keto reductase
A1D75_RS04145	COG0142	geranyltranstransferase activity
A1D75_RS04160	COG0693	protein deglycase activity
A1D75_RS04165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A1D75_RS04175	COG2814	Major facilitator Superfamily
A1D75_RS04185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A1D75_RS04190	COG1845	cytochrome c oxidase, subunit III
A1D75_RS04195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A1D75_RS04200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A1D75_RS04205	COG2223	nitrite transmembrane transporter activity
A1D75_RS04210	COG3056	Lipoprotein
A1D75_RS04215	COG0271	Belongs to the BolA IbaG family
A1D75_RS04235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A1D75_RS04240	COG0776	regulation of translation
A1D75_RS04245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A1D75_RS04250	COG1555	photosystem II stabilization
A1D75_RS04255	COG0824	Thioesterase
A1D75_RS04265	COG4533	DNA binding
A1D75_RS04275	COG1522	sequence-specific DNA binding
A1D75_RS04280	COG1132	(ABC) transporter
A1D75_RS04285	COG1132	(ABC) transporter
A1D75_RS04290	COG0347	Belongs to the P(II) protein family
A1D75_RS04295	COG0004	ammonium transporteR
A1D75_RS04300	COG1946	Acyl-CoA thioesterase
A1D75_RS04305	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A1D75_RS04310	COG3695	enzyme binding
A1D75_RS04320	COG5507	3-demethylubiquinone-9 3-methyltransferase
A1D75_RS04325	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A1D75_RS04335	COG0110	maltose O-acetyltransferase activity
A1D75_RS04350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1D75_RS04355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1D75_RS04360	COG1309	transcriptional regulator
A1D75_RS04365	COG3264	Mechanosensitive ion channel
A1D75_RS04365	COG1196	nuclear chromosome segregation
A1D75_RS04375	COG3923	Primosomal replication protein n
A1D75_RS04380	COG2832	Protein of unknown function (DUF454)
A1D75_RS04390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A1D75_RS04425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1D75_RS04430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A1D75_RS04430	COG4651	solute:proton antiporter activity
A1D75_RS04435	COG2223	nitrite transmembrane transporter activity
A1D75_RS04440	COG0737	Belongs to the 5'-nucleotidase family
A1D75_RS04445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A1D75_RS04450	COG3735	TraB family
A1D75_RS04460	COG3093	addiction module antidote protein HigA
A1D75_RS04465	COG2217	Heavy metal translocating P-type atpase
A1D75_RS04470	COG2066	Belongs to the glutaminase family
A1D75_RS04475	COG0531	amino acid
A1D75_RS04510	COG2842	Transposition protein
A1D75_RS04540	COG4396	Host-nuclease inhibitor protein Gam
A1D75_RS04595	COG5566	PFAM Mor transcription activator
A1D75_RS04635	COG4373	Mu-like prophage FluMu protein gp28
A1D75_RS04645	COG2369	cell adhesion
A1D75_RS04650	COG5005	Phage virion morphogenesis
A1D75_RS04655	COG4388	Caudovirus prohead serine protease
A1D75_RS04660	COG4397	Mu-like prophage major head subunit gpT
A1D75_RS04685	COG4386	tail sheath protein
A1D75_RS04695	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
A1D75_RS04720	COG4384	Bacteriophage Mu Gp45 protein
A1D75_RS04730	COG3299	homolog of phage Mu protein gp47
A1D75_RS04760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A1D75_RS04795	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A1D75_RS04800	COG2425	protein containing a von Willebrand factor type A (vWA) domain
A1D75_RS04805	COG0714	Associated with various cellular activities
A1D75_RS04815	COG3831	ATPase activity
A1D75_RS04820	COG3831	ATPase activity
A1D75_RS04825	COG3831	ATPase activity
A1D75_RS04840	COG0489	protein tyrosine kinase activity
A1D75_RS04850	COG3539	Fimbrial protein
A1D75_RS04855	COG3121	Chaperone
A1D75_RS04860	COG3188	usher protein
A1D75_RS04865	COG3539	Fimbrial protein
A1D75_RS04870	COG5455	response to cobalt ion
A1D75_RS04875	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A1D75_RS04910	COG0351	phosphomethylpyrimidine kinase
A1D75_RS04915	COG3757	hydrolase, family 25
A1D75_RS04920	COG2188	Transcriptional regulator
A1D75_RS04925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1D75_RS04930	COG1397	ADP-ribosylglycohydrolase
A1D75_RS04935	COG2211	Major facilitator Superfamily
A1D75_RS04940	COG1830	Aldolase
A1D75_RS04955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS04960	COG3414	Phosphotransferase system galactitol-specific IIB component
A1D75_RS04965	COG3775	system Galactitol-specific IIC component
A1D75_RS04970	COG1063	alcohol dehydrogenase
A1D75_RS04995	COG0826	peptidase U32
A1D75_RS05000	COG3422	double-strand break repair
A1D75_RS05005	COG0745	RESPONSE REGULATOR receiver
A1D75_RS05010	COG2205	protein histidine kinase activity
A1D75_RS05025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1D75_RS05050	COG4245	von Willebrand factor, type A
A1D75_RS05055	COG0631	protein serine/threonine phosphatase activity
A1D75_RS05060	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
A1D75_RS05065	COG0443	Heat shock 70 kDa protein
A1D75_RS05070	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A1D75_RS05080	COG0572	uridine kinase
A1D75_RS05090	COG2982	Protein involved in outer membrane biogenesis
A1D75_RS05105	COG1253	flavin adenine dinucleotide binding
A1D75_RS05110	COG1596	polysaccharide export
A1D75_RS05115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A1D75_RS05120	COG0489	protein tyrosine kinase activity
A1D75_RS05120	COG3206	protein involved in exopolysaccharide biosynthesis
A1D75_RS05125	COG0463	Glycosyl transferase, family 2
A1D75_RS05130	COG1045	serine acetyltransferase
A1D75_RS05135	COG0438	transferase activity, transferring glycosyl groups
A1D75_RS05145	COG1216	Glycosyl transferase, family 2
A1D75_RS05150	COG0110	maltose O-acetyltransferase activity
A1D75_RS05155	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A1D75_RS05160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1D75_RS05165	COG1051	belongs to the nudix hydrolase family
A1D75_RS05170	COG0297	glycogen (starch) synthase activity
A1D75_RS05175	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A1D75_RS05175	COG0662	Cupin 2, conserved barrel domain protein
A1D75_RS05180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1D75_RS05185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A1D75_RS05190	COG2244	polysaccharide biosynthetic process
A1D75_RS05195	COG2327	Polysaccharide pyruvyl transferase
A1D75_RS05200	COG0438	transferase activity, transferring glycosyl groups
A1D75_RS05210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1D75_RS05215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A1D75_RS05240	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A1D75_RS05250	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A1D75_RS05255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1D75_RS05260	COG1051	belongs to the nudix hydrolase family
A1D75_RS05265	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A1D75_RS05265	COG0662	Cupin 2, conserved barrel domain protein
A1D75_RS05270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1D75_RS05285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A1D75_RS05290	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A1D75_RS05320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A1D75_RS05325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A1D75_RS05325	COG0131	Imidazoleglycerol-phosphate dehydratase
A1D75_RS05335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A1D75_RS05350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1D75_RS05355	COG0583	DNA-binding transcription factor activity
A1D75_RS05365	COG0531	amino acid
A1D75_RS05370	COG2391	methyltransferase activity
A1D75_RS05375	COG0425	Belongs to the sulfur carrier protein TusA family
A1D75_RS05380	COG2925	Exonuclease
A1D75_RS05385	COG1686	Belongs to the peptidase S11 family
A1D75_RS05395	COG1289	transmembrane transporter activity
A1D75_RS05405	COG4917	ethanolamine utilization protein
A1D75_RS05440	COG2003	Belongs to the UPF0758 family
A1D75_RS05490	COG4771	TonB-dependent receptor
A1D75_RS05505	COG4372	Transposase
A1D75_RS05510	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS05525	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
A1D75_RS05540	COG1376	ErfK ybiS ycfS ynhG family protein
A1D75_RS05550	COG0583	DNA-binding transcription factor activity
A1D75_RS05555	COG0583	DNA-binding transcription factor activity
A1D75_RS05575	COG0217	transcriptional regulatory protein
A1D75_RS05580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A1D75_RS05585	COG0477	Major facilitator Superfamily
A1D75_RS05595	COG2373	Large extracellular alpha-helical protein
A1D75_RS05595	COG1388	LysM domain
A1D75_RS05595	COG4932	domain protein
A1D75_RS05625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1D75_RS05670	COG1846	Transcriptional regulator
A1D75_RS05720	COG1403	HNH endonuclease
A1D75_RS05725	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A1D75_RS05785	COG3772	lysozyme
A1D75_RS05820	COG4220	transposase activity
A1D75_RS05910	COG5301	cellulose 1,4-beta-cellobiosidase activity
A1D75_RS05935	COG3038	cytochrome b561
A1D75_RS05940	COG3443	Belongs to the bacterial solute-binding protein 9 family
A1D75_RS05955	COG2351	hydroxyisourate hydrolase activity
A1D75_RS05960	COG0745	RESPONSE REGULATOR receiver
A1D75_RS05965	COG2205	protein histidine kinase activity
A1D75_RS05990	COG1418	mRNA catabolic process
A1D75_RS05995	COG0270	DNA (cytosine-5-)-methyltransferase activity
A1D75_RS06000	COG3727	T/G mismatch-specific endonuclease activity
A1D75_RS06005	COG0697	spore germination
A1D75_RS06010	COG2354	Protein conserved in bacteria
A1D75_RS06015	COG5475	Uncharacterized small protein (DUF2158)
A1D75_RS06020	COG3706	GGDEF domain
A1D75_RS06045	COG2197	response regulator
A1D75_RS06050	COG1684	flagellar biosynthetic protein fliR
A1D75_RS06055	COG1987	bacterial-type flagellum assembly
A1D75_RS06060	COG1338	Plays a role in the flagellum-specific transport system
A1D75_RS06065	COG3190	flagellar
A1D75_RS06070	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A1D75_RS06075	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A1D75_RS06080	COG1580	Controls the rotational direction of flagella during chemotaxis
A1D75_RS06085	COG3144	bacterial-type flagellum assembly
A1D75_RS06090	COG2882	bacterial-type flagellum organization
A1D75_RS06095	COG1157	protein secretion by the type III secretion system
A1D75_RS06100	COG1317	bacterial-type flagellum organization
A1D75_RS06105	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A1D75_RS06110	COG1766	The M ring may be actively involved in energy transduction
A1D75_RS06130	COG0454	-acetyltransferase
A1D75_RS06145	COG0454	-acetyltransferase
A1D75_RS06150	COG2135	peptidase activity
A1D75_RS06155	COG0425	Belongs to the sulfur carrier protein TusA family
A1D75_RS06160	COG2391	methyltransferase activity
A1D75_RS06170	COG0366	Alpha amylase catalytic
A1D75_RS06180	COG1516	flagellar protein fliS
A1D75_RS06185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A1D75_RS06195	COG1191	sigma factor activity
A1D75_RS06205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1D75_RS06215	COG0765	amino acid transport
A1D75_RS06220	COG1126	abc transporter atp-binding protein
A1D75_RS06225	COG2197	response regulator
A1D75_RS06245	COG2197	response regulator
A1D75_RS06285	COG2826	transposase and inactivated derivatives, IS30 family
A1D75_RS06435	COG4974	Belongs to the 'phage' integrase family
A1D75_RS06440	COG3012	SEC-C Motif Domain Protein
A1D75_RS06440	COG3318	Belongs to the UPF0149 family
A1D75_RS06445	COG0814	amino acid
A1D75_RS06455	COG1528	Iron-storage protein
A1D75_RS06475	COG1528	Iron-storage protein
A1D75_RS06480	COG1879	ABC-type sugar transport system periplasmic component
A1D75_RS06485	COG1129	ABC transporter
A1D75_RS06490	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS06495	COG1877	trehalose-phosphatase activity
A1D75_RS06500	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A1D75_RS06505	COG0589	response to stress
A1D75_RS06520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A1D75_RS06525	COG1360	Flagellar Motor Protein
A1D75_RS06530	COG0643	Histidine kinase
A1D75_RS06530	COG2198	Histidine kinase
A1D75_RS06535	COG0835	chemotaxis
A1D75_RS06540	COG0840	transmembrane signaling receptor activity
A1D75_RS06545	COG0840	transmembrane signaling receptor activity
A1D75_RS06550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A1D75_RS06555	COG2201	protein-glutamate methylesterase activity
A1D75_RS06560	COG0745	RESPONSE REGULATOR receiver
A1D75_RS06570	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A1D75_RS06575	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A1D75_RS06585	COG3755	Protein conserved in bacteria
A1D75_RS06595	COG3102	Protein conserved in bacteria
A1D75_RS06605	COG3005	denitrification pathway
A1D75_RS06610	COG0243	molybdopterin cofactor binding
A1D75_RS06625	COG3788	relative of glutathione S-transferase, MAPEG superfamily
A1D75_RS06630	COG1801	Protein of unknown function DUF72
A1D75_RS06635	COG1335	isochorismatase
A1D75_RS06640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A1D75_RS06645	COG0494	nUDIX hydrolase
A1D75_RS06650	COG0217	transcriptional regulatory protein
A1D75_RS06680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A1D75_RS06690	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A1D75_RS06695	COG0739	heme binding
A1D75_RS06700	COG1560	Kdo2-lipid A biosynthetic process
A1D75_RS06705	COG0469	pyruvate kinase activity
A1D75_RS06710	COG1737	Transcriptional regulator
A1D75_RS06715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A1D75_RS06720	COG0129	dihydroxy-acid dehydratase activity
A1D75_RS06725	COG0800	Aldolase
A1D75_RS06730	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A1D75_RS06735	COG3141	response to X-ray
A1D75_RS06745	COG2979	Protein of unknown function (DUF533)
A1D75_RS06750	COG1770	oligopeptidase
A1D75_RS06755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1D75_RS06760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A1D75_RS06770	COG2372	response to copper ion
A1D75_RS06775	COG1276	copper resistance
A1D75_RS06785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A1D75_RS06805	COG3008	intermembrane lipid transfer
A1D75_RS06810	COG2995	paraquat-inducible protein a
A1D75_RS06815	COG1956	GAF domain-containing protein
A1D75_RS06825	COG0793	Belongs to the peptidase S41A family
A1D75_RS06835	COG2814	Major facilitator Superfamily
A1D75_RS06840	COG1414	Transcriptional regulator
A1D75_RS06870	COG2226	methyltransferase
A1D75_RS06885	COG3716	PTS system mannose fructose sorbose family IID component
A1D75_RS06890	COG3715	PTS system
A1D75_RS06895	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS06895	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1D75_RS06900	COG1253	flavin adenine dinucleotide binding
A1D75_RS06905	COG2200	EAL domain
A1D75_RS06910	COG1760	l-serine dehydratase
A1D75_RS06920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A1D75_RS06935	COG0251	oxidation-reduction process
A1D75_RS06940	COG1199	ATP-dependent helicase activity
A1D75_RS06945	COG1214	PFAM Peptidase M22, glycoprotease
A1D75_RS06950	COG3065	identical protein binding
A1D75_RS06955	COG0318	PFAM AMP-dependent synthetase and ligase
A1D75_RS06960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A1D75_RS06965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1D75_RS06970	COG4638	Rieske (2fe-2S)
A1D75_RS06975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A1D75_RS06980	COG0473	3-isopropylmalate dehydrogenase activity
A1D75_RS06985	COG0583	DNA-binding transcription factor activity
A1D75_RS06990	COG1280	lysine exporter protein (LysE YggA)
A1D75_RS06995	COG3615	Tellurite resistance protein tehB
A1D75_RS07005	COG2261	transglycosylase associated protein
A1D75_RS07025	COG3042	response to heat
A1D75_RS07030	COG3189	MarR family transcriptional regulator
A1D75_RS07035	COG2807	transmembrane transport
A1D75_RS07040	COG2207	Transcriptional regulator
A1D75_RS07055	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A1D75_RS07060	COG2199	diguanylate cyclase activity
A1D75_RS07065	COG2199	diguanylate cyclase activity
A1D75_RS07075	COG2766	serine protein kinase
A1D75_RS07080	COG3713	MltA-interacting MipA family protein
A1D75_RS07085	COG0656	L-ascorbic acid biosynthetic process
A1D75_RS07090	COG0676	glucose-6-phosphate 1-epimerase activity
A1D75_RS07095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A1D75_RS07105	COG3139	Protein of unknown function (DUF1315)
A1D75_RS07110	COG1063	alcohol dehydrogenase
A1D75_RS07115	COG2271	Major facilitator Superfamily
A1D75_RS07120	COG1063	alcohol dehydrogenase
A1D75_RS07125	COG0191	fructose-bisphosphate aldolase activity
A1D75_RS07130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1D75_RS07135	COG0667	Aldo Keto reductase
A1D75_RS07140	COG1349	DNA-binding transcription factor activity
A1D75_RS07145	COG2814	Major facilitator Superfamily
A1D75_RS07150	COG1335	isochorismatase
A1D75_RS07155	COG0252	asparaginase activity
A1D75_RS07165	COG0616	signal peptide processing
A1D75_RS07170	COG0778	Nitroreductase
A1D75_RS07175	COG0709	Synthesizes selenophosphate from selenide and ATP
A1D75_RS07180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A1D75_RS07190	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A1D75_RS07200	COG0494	nUDIX hydrolase
A1D75_RS07205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A1D75_RS07210	COG2897	thiosulfate sulfurtransferase activity
A1D75_RS07215	COG4136	ATPase activity
A1D75_RS07220	COG4135	transport system, permease component
A1D75_RS07225	COG4134	Bacterial extracellular solute-binding protein
A1D75_RS07230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A1D75_RS07235	COG0398	Pfam SNARE associated Golgi protein
A1D75_RS07245	COG0398	Pfam SNARE associated Golgi protein
A1D75_RS07250	COG0708	Exodeoxyribonuclease III
A1D75_RS07280	COG3678	ATP-independent chaperone mediated protein folding
A1D75_RS07290	COG0322	excinuclease ABC activity
A1D75_RS07300	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A1D75_RS07310	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A1D75_RS07315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A1D75_RS07320	COG1447	Phosphotransferase system cellobiose-specific component IIA
A1D75_RS07325	COG2169	Transcriptional regulator
A1D75_RS07325	COG1917	Cupin 2, conserved barrel domain protein
A1D75_RS07330	COG1486	melibiose metabolic process
A1D75_RS07340	COG0753	catalase activity
A1D75_RS07355	COG1823	symporter activity
A1D75_RS07360	COG1988	membrane-bound metal-dependent
A1D75_RS07365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A1D75_RS07375	COG3001	Fructosamine kinase
A1D75_RS07385	COG1105	Belongs to the carbohydrate kinase PfkB family
A1D75_RS07390	COG3137	Salt-induced outer membrane protein
A1D75_RS07435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1D75_RS07435	COG0072	phenylalanine-tRNA ligase activity
A1D75_RS07450	COG0386	Belongs to the glutathione peroxidase family
A1D75_RS07460	COG0791	NLP P60 protein
A1D75_RS07465	COG2200	EAL domain
A1D75_RS07475	COG4256	Hemin uptake protein
A1D75_RS07480	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A1D75_RS07490	COG0574	Belongs to the PEP-utilizing enzyme family
A1D75_RS07490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A1D75_RS07495	COG0318	PFAM AMP-dependent synthetase and ligase
A1D75_RS07500	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A1D75_RS07505	COG0644	oxidoreductase
A1D75_RS07510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A1D75_RS07515	COG2086	electron transfer activity
A1D75_RS07520	COG1917	Cupin 2, conserved barrel domain protein
A1D75_RS07520	COG2207	Transcriptional regulator
A1D75_RS07525	COG1960	acyl-CoA dehydrogenase activity
A1D75_RS07530	COG4670	ketone body catabolic process
A1D75_RS07545	COG2271	Major facilitator Superfamily
A1D75_RS07550	COG0738	Major facilitator superfamily
A1D75_RS07565	COG0628	permease
A1D75_RS07570	COG0277	FAD linked oxidase domain protein
A1D75_RS07570	COG0247	lactate metabolic process
A1D75_RS07575	COG2050	protein possibly involved in aromatic compounds catabolism
A1D75_RS07585	COG0316	Belongs to the HesB IscA family
A1D75_RS07590	COG0719	Fe-S assembly protein
A1D75_RS07595	COG0396	ATPase activity
A1D75_RS07600	COG0719	Fe-S assembly protein
A1D75_RS07615	COG1376	ErfK ybiS ycfS ynhG family protein
A1D75_RS07620	COG4238	major outer membrane lipoprotein
A1D75_RS07625	COG0469	pyruvate kinase activity
A1D75_RS07635	COG0437	4 iron, 4 sulfur cluster binding
A1D75_RS07640	COG2414	aldehyde ferredoxin oxidoreductase
A1D75_RS07650	COG0437	4 iron, 4 sulfur cluster binding
A1D75_RS07655	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
A1D75_RS07665	COG4529	Protein conserved in bacteria
A1D75_RS07685	COG3468	outer membrane autotransporter barrel domain protein
A1D75_RS07695	COG0307	riboflavin synthase, alpha
A1D75_RS07700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A1D75_RS07705	COG2814	Major facilitator Superfamily
A1D75_RS07710	COG0583	DNA-binding transcription factor activity
A1D75_RS07725	COG2814	Major facilitator Superfamily
A1D75_RS07730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A1D75_RS07735	COG0791	NLP P60 protein
A1D75_RS07740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A1D75_RS07745	COG1201	RNA secondary structure unwinding
A1D75_RS07755	COG0346	lactoylglutathione lyase activity
A1D75_RS07760	COG1902	pentaerythritol trinitrate reductase activity
A1D75_RS07765	COG1309	transcriptional regulator
A1D75_RS07770	COG3313	Fe-S protein
A1D75_RS07775	COG4989	oxidoreductase activity
A1D75_RS07780	COG2032	superoxide dismutase activity
A1D75_RS07785	COG1289	transmembrane transporter activity
A1D75_RS07790	COG1566	PFAM secretion protein HlyD family protein
A1D75_RS07805	COG3133	Outer membrane lipoprotein
A1D75_RS07815	COG3895	Periplasmic Protein
A1D75_RS07830	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A1D75_RS07835	COG0625	glutathione transferase activity
A1D75_RS07840	COG3104	oligopeptide transport
A1D75_RS07850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A1D75_RS07860	COG4659	FMN binding
A1D75_RS07870	COG4656	Part of a membrane complex involved in electron transport
A1D75_RS07900	COG0673	inositol 2-dehydrogenase activity
A1D75_RS07910	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A1D75_RS07915	COG1263	PTS System
A1D75_RS07915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1D75_RS07920	COG1609	Transcriptional regulator
A1D75_RS07925	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS07930	COG1309	transcriptional regulator
A1D75_RS07950	COG5339	Protein conserved in bacteria
A1D75_RS07955	COG1482	cell wall glycoprotein biosynthetic process
A1D75_RS07960	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A1D75_RS07960	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A1D75_RS07965	COG0114	fumarate hydratase activity
A1D75_RS07975	COG2205	protein histidine kinase activity
A1D75_RS07980	COG0745	RESPONSE REGULATOR receiver
A1D75_RS07985	COG3136	membrane protein required for alginate biosynthesis
A1D75_RS07995	COG0531	amino acid
A1D75_RS08005	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A1D75_RS08010	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A1D75_RS08015	COG0628	permease
A1D75_RS08035	COG3591	Belongs to the peptidase S1B family
A1D75_RS08050	COG2814	Major facilitator Superfamily
A1D75_RS08055	COG0583	DNA-binding transcription factor activity
A1D75_RS08060	COG1940	carbohydrate kinase activity
A1D75_RS08065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A1D75_RS08075	COG3381	protein complex oligomerization
A1D75_RS08080	COG3302	dmso reductase anchor subunit
A1D75_RS08085	COG0437	4 iron, 4 sulfur cluster binding
A1D75_RS08090	COG0243	molybdopterin cofactor binding
A1D75_RS08095	COG0243	molybdopterin cofactor binding
A1D75_RS08110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A1D75_RS08140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1D75_RS08195	COG1846	Transcriptional regulator
A1D75_RS08200	COG1484	DNA-dependent DNA replication
A1D75_RS08235	COG1403	HNH endonuclease
A1D75_RS08240	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A1D75_RS08295	COG3772	lysozyme
A1D75_RS08435	COG5301	cellulose 1,4-beta-cellobiosidase activity
A1D75_RS08485	COG4372	Transposase
A1D75_RS08490	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS08545	COG3685	Protein conserved in bacteria
A1D75_RS08550	COG3685	Protein conserved in bacteria
A1D75_RS08555	COG3729	General stress protein
A1D75_RS08570	COG0135	phosphoribosylanthranilate isomerase activity
A1D75_RS08570	COG0134	indole-3-glycerol-phosphate synthase activity
A1D75_RS08575	COG0512	Glutamine amidotransferase of anthranilate synthase
A1D75_RS08575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A1D75_RS08580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A1D75_RS08590	COG0613	PHP domain protein
A1D75_RS08595	COG0009	L-threonylcarbamoyladenylate synthase
A1D75_RS08600	COG4907	membrane protein (DUF2207)
A1D75_RS08605	COG1187	pseudouridine synthase activity
A1D75_RS08610	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A1D75_RS08615	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS08620	COG0616	signal peptide processing
A1D75_RS08630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A1D75_RS08635	COG0583	DNA-binding transcription factor activity
A1D75_RS08655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A1D75_RS08665	COG0671	phosphoesterase, PA-phosphatase related
A1D75_RS08670	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A1D75_RS08675	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A1D75_RS08685	COG0023	Translation Initiation Factor
A1D75_RS08695	COG1349	DNA-binding transcription factor activity
A1D75_RS08705	COG5001	Diguanylate cyclase
A1D75_RS08715	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A1D75_RS08715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A1D75_RS08720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A1D75_RS08730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1D75_RS08735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1D75_RS08745	COG2814	Major facilitator Superfamily
A1D75_RS08750	COG4172	Belongs to the ABC transporter superfamily
A1D75_RS08755	COG4172	Belongs to the ABC transporter superfamily
A1D75_RS08760	COG4171	peptide transport system, permease
A1D75_RS08765	COG4168	peptide transport system, permease
A1D75_RS08770	COG4166	transmembrane transport
A1D75_RS08780	COG0531	amino acid
A1D75_RS08790	COG0174	glutamine synthetase
A1D75_RS08795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A1D75_RS08800	COG1917	Cupin 2, conserved barrel domain protein
A1D75_RS08800	COG1396	sequence-specific DNA binding
A1D75_RS08805	COG1012	belongs to the aldehyde dehydrogenase family
A1D75_RS08810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A1D75_RS08815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A1D75_RS08820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A1D75_RS08825	COG1842	Phage shock protein A
A1D75_RS08835	COG1983	PspC domain protein
A1D75_RS08845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A1D75_RS08850	COG0366	Alpha amylase catalytic
A1D75_RS08855	COG0366	Alpha amylase catalytic
A1D75_RS08865	COG1175	transmembrane transport
A1D75_RS08870	COG0395	ABC-type sugar transport system, permease component
A1D75_RS08875	COG1063	alcohol dehydrogenase
A1D75_RS08880	COG1082	Xylose isomerase domain protein TIM barrel
A1D75_RS08885	COG0673	inositol 2-dehydrogenase activity
A1D75_RS08890	COG1554	hydrolase, family 65, central catalytic
A1D75_RS08895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A1D75_RS08900	COG3842	ATPase activity
A1D75_RS08910	COG1609	Transcriptional regulator
A1D75_RS08915	COG3106	COG3106 Predicted ATPase
A1D75_RS08925	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A1D75_RS08930	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A1D75_RS08935	COG4948	Mandelate Racemase Muconate Lactonizing
A1D75_RS08940	COG2866	Carboxypeptidase
A1D75_RS08945	COG0702	epimerase
A1D75_RS08955	COG1073	alpha beta
A1D75_RS08960	COG0583	DNA-binding transcription factor activity
A1D75_RS08965	COG4166	transmembrane transport
A1D75_RS08970	COG0668	transmembrane transport
A1D75_RS08975	COG3182	Iron-regulated membrane protein
A1D75_RS08980	COG0589	response to stress
A1D75_RS08985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A1D75_RS08990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A1D75_RS09010	COG1473	amidohydrolase
A1D75_RS09015	COG1473	amidohydrolase
A1D75_RS09020	COG0583	DNA-binding transcription factor activity
A1D75_RS09025	COG2840	Smr protein MutS2
A1D75_RS09030	COG3706	GGDEF domain
A1D75_RS09045	COG0513	Belongs to the DEAD box helicase family
A1D75_RS09055	COG0582	viral genome integration into host DNA
A1D75_RS09075	COG3723	Recombinational DNA repair protein, rece pathway
A1D75_RS09080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1D75_RS09135	COG3756	Protein conserved in bacteria
A1D75_RS09140	COG1484	DNA-dependent DNA replication
A1D75_RS09145	COG1846	Transcriptional regulator
A1D75_RS09245	COG3772	lysozyme
A1D75_RS09385	COG2032	superoxide dismutase activity
A1D75_RS09400	COG5301	cellulose 1,4-beta-cellobiosidase activity
A1D75_RS09425	COG0589	response to stress
A1D75_RS09435	COG1013	pyruvate-flavodoxin oxidoreductase activity
A1D75_RS09435	COG0674	pyruvate-flavodoxin oxidoreductase activity
A1D75_RS09435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1D75_RS09435	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A1D75_RS09440	COG3042	response to heat
A1D75_RS09445	COG3187	Heat shock protein
A1D75_RS09450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A1D75_RS09455	COG2911	Protein conserved in bacteria
A1D75_RS09465	COG3784	Protein of unknown function (DUF1318)
A1D75_RS09480	COG0667	Aldo Keto reductase
A1D75_RS09490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A1D75_RS09495	COG4589	Belongs to the CDS family
A1D75_RS09500	COG2267	carboxylic ester hydrolase activity
A1D75_RS09505	COG0671	phosphoesterase, PA-phosphatase related
A1D75_RS09505	COG2453	phosphatase
A1D75_RS09510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A1D75_RS09515	COG1643	Atp-dependent helicase
A1D75_RS09540	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A1D75_RS09545	COG1012	belongs to the aldehyde dehydrogenase family
A1D75_RS09550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A1D75_RS09555	COG3038	cytochrome b561
A1D75_RS09575	COG0840	transmembrane signaling receptor activity
A1D75_RS09580	COG0583	DNA-binding transcription factor activity
A1D75_RS09585	COG5383	Protein conserved in bacteria
A1D75_RS09595	COG2841	Protein conserved in bacteria
A1D75_RS09605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A1D75_RS09610	COG1275	C4-dicarboxylate transporter malic acid transport protein
A1D75_RS09615	COG0500	methyltransferase
A1D75_RS09625	COG3135	benzoate transporter
A1D75_RS09630	COG1396	sequence-specific DNA binding
A1D75_RS09635	COG0826	peptidase U32
A1D75_RS09645	COG1724	mRNA binding
A1D75_RS09650	COG1598	PFAM Uncharacterised protein family UPF0150
A1D75_RS09655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1D75_RS09660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A1D75_RS09665	COG3842	ATPase activity
A1D75_RS09670	COG1176	ABC-type spermidine putrescine transport system, permease component I
A1D75_RS09675	COG1177	transmembrane transport
A1D75_RS09700	COG3238	Protein conserved in bacteria
A1D75_RS09705	COG1247	-acetyltransferase
A1D75_RS09710	COG2130	NADP-dependent
A1D75_RS09715	COG1802	Transcriptional regulator
A1D75_RS09720	COG4772	TonB-dependent receptor
A1D75_RS09725	COG3391	amine dehydrogenase activity
A1D75_RS09730	COG1113	amino acid transport
A1D75_RS09735	COG0625	glutathione transferase activity
A1D75_RS09750	COG3209	COG3209 Rhs family protein
A1D75_RS09780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A1D75_RS09790	COG0384	phenazine biosynthesis protein PhzF
A1D75_RS09795	COG2181	nitrate reductase activity
A1D75_RS09800	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A1D75_RS09805	COG1140	nitrate reductase beta subunit
A1D75_RS09810	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A1D75_RS09815	COG2223	nitrite transmembrane transporter activity
A1D75_RS09820	COG4886	Leucine-rich repeat (LRR) protein
A1D75_RS09825	COG4886	Leucine-rich repeat (LRR) protein
A1D75_RS09840	COG0697	spore germination
A1D75_RS09845	COG0243	molybdopterin cofactor binding
A1D75_RS09845	COG3383	formate dehydrogenase (NAD+) activity
A1D75_RS09850	COG0243	molybdopterin cofactor binding
A1D75_RS09850	COG3383	formate dehydrogenase (NAD+) activity
A1D75_RS09855	COG0437	4 iron, 4 sulfur cluster binding
A1D75_RS09860	COG2864	formate dehydrogenase
A1D75_RS09865	COG3093	addiction module antidote protein HigA
A1D75_RS09870	COG1064	alcohol dehydrogenase
A1D75_RS09890	COG1764	response to oxidative stress
A1D75_RS09895	COG4608	Belongs to the ABC transporter superfamily
A1D75_RS09900	COG0444	Belongs to the ABC transporter superfamily
A1D75_RS09905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A1D75_RS09910	COG0601	transmembrane transport
A1D75_RS09915	COG0747	negative chemotaxis
A1D75_RS09920	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
A1D75_RS09930	COG3706	GGDEF domain
A1D75_RS09935	COG1649	PFAM Uncharacterised BCR, COG1649
A1D75_RS09940	COG0531	amino acid
A1D75_RS09945	COG0076	glutamate decarboxylase activity
A1D75_RS09950	COG0612	Peptidase, M16
A1D75_RS09955	COG4771	TonB-dependent receptor
A1D75_RS09960	COG4178	(ABC) transporter
A1D75_RS09970	COG0641	radical SAM
A1D75_RS09975	COG3119	arylsulfatase activity
A1D75_RS09980	COG2207	Transcriptional regulator
A1D75_RS09990	COG0243	molybdopterin cofactor binding
A1D75_RS09995	COG3539	Fimbrial protein
A1D75_RS10000	COG3539	Fimbrial protein
A1D75_RS10005	COG3539	Fimbrial protein
A1D75_RS10010	COG3188	usher protein
A1D75_RS10020	COG3539	Fimbrial protein
A1D75_RS10045	COG3210	domain, Protein
A1D75_RS10045	COG2911	Protein conserved in bacteria
A1D75_RS10050	COG1070	Carbohydrate kinase
A1D75_RS10060	COG1129	ABC transporter
A1D75_RS10065	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS10070	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS10080	COG1830	Aldolase
A1D75_RS10095	COG3781	membrane
A1D75_RS10105	COG2199	diguanylate cyclase activity
A1D75_RS10115	COG2066	Belongs to the glutaminase family
A1D75_RS10120	COG1012	belongs to the aldehyde dehydrogenase family
A1D75_RS10125	COG0583	DNA-binding transcription factor activity
A1D75_RS10140	COG2814	Major facilitator Superfamily
A1D75_RS10145	COG2095	MarC family integral membrane protein
A1D75_RS10150	COG1846	Transcriptional regulator
A1D75_RS10155	COG4977	sequence-specific DNA binding
A1D75_RS10165	COG0697	spore germination
A1D75_RS10170	COG2814	Major facilitator Superfamily
A1D75_RS10190	COG3706	GGDEF domain
A1D75_RS10195	COG3111	PFAM Bacterial OB fold (BOF) protein
A1D75_RS10200	COG1546	Belongs to the CinA family
A1D75_RS10205	COG0339	signal peptide processing
A1D75_RS10210	COG4221	oxidoreductase activity
A1D75_RS10215	COG1802	Transcriptional regulator
A1D75_RS10225	COG0246	Mannitol dehydrogenase
A1D75_RS10230	COG0477	Major facilitator Superfamily
A1D75_RS10265	COG5301	cellulose 1,4-beta-cellobiosidase activity
A1D75_RS10350	COG1030	water channel activity
A1D75_RS10370	COG4220	transposase activity
A1D75_RS10405	COG3772	lysozyme
A1D75_RS10445	COG2207	Transcriptional regulator
A1D75_RS10460	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A1D75_RS10465	COG1403	HNH endonuclease
A1D75_RS10475	COG3111	PFAM Bacterial OB fold (BOF) protein
A1D75_RS10510	COG1846	Transcriptional regulator
A1D75_RS10570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1D75_RS10575	COG0582	viral genome integration into host DNA
A1D75_RS10595	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS10600	COG4372	Transposase
A1D75_RS10630	COG5301	cellulose 1,4-beta-cellobiosidase activity
A1D75_RS10760	COG3772	lysozyme
A1D75_RS10810	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A1D75_RS10815	COG1403	HNH endonuclease
A1D75_RS10850	COG1846	Transcriptional regulator
A1D75_RS10880	COG1396	sequence-specific DNA binding
A1D75_RS10925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1D75_RS10935	COG0582	viral genome integration into host DNA
A1D75_RS10940	COG3047	cAMP biosynthetic process
A1D75_RS10960	COG1607	acyl-coa hydrolase
A1D75_RS10965	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A1D75_RS10970	COG2350	Protein conserved in bacteria
A1D75_RS10975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A1D75_RS10995	COG4608	Belongs to the ABC transporter superfamily
A1D75_RS11000	COG0444	Belongs to the ABC transporter superfamily
A1D75_RS11005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A1D75_RS11010	COG0601	transmembrane transport
A1D75_RS11015	COG4166	transmembrane transport
A1D75_RS11020	COG2095	MarC family integral membrane protein
A1D75_RS11025	COG1012	belongs to the aldehyde dehydrogenase family
A1D75_RS11025	COG1454	alcohol dehydrogenase
A1D75_RS11030	COG1435	thymidine kinase activity
A1D75_RS11040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A1D75_RS11045	COG0745	RESPONSE REGULATOR receiver
A1D75_RS11050	COG1752	Esterase of the alpha-beta hydrolase superfamily
A1D75_RS11060	COG0788	formyltetrahydrofolate deformylase activity
A1D75_RS11090	COG2181	nitrate reductase activity
A1D75_RS11095	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A1D75_RS11100	COG1140	nitrate reductase beta subunit
A1D75_RS11105	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A1D75_RS11110	COG2223	nitrite transmembrane transporter activity
A1D75_RS11115	COG3850	Histidine kinase
A1D75_RS11120	COG2197	response regulator
A1D75_RS11125	COG4932	domain protein
A1D75_RS11130	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A1D75_RS11135	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A1D75_RS11140	COG4572	Cation transport regulator
A1D75_RS11145	COG0387	Pfam Sodium calcium exchanger
A1D75_RS11165	COG2912	Transglutaminase-like superfamily
A1D75_RS11170	COG3094	Invasion gene expression up-regulator, SirB
A1D75_RS11200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A1D75_RS11205	COG0659	secondary active sulfate transmembrane transporter activity
A1D75_RS11220	COG0012	GTP binding
A1D75_RS11230	COG2376	Dihydroxyacetone kinase
A1D75_RS11235	COG1461	Dihydroxyacetone kinase
A1D75_RS11240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS11240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A1D75_RS11240	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A1D75_RS11250	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A1D75_RS11260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A1D75_RS11265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1D75_RS11270	COG1120	ATPase activity
A1D75_RS11275	COG0500	methyltransferase
A1D75_RS11285	COG0157	Belongs to the NadC ModD family
A1D75_RS11310	COG1619	proteins homologs of microcin C7 resistance protein MccF
A1D75_RS11320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A1D75_RS11330	COG2719	SpoVR family
A1D75_RS11345	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A1D75_RS11350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A1D75_RS11355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A1D75_RS11370	COG0179	Fumarylacetoacetate (FAA) hydrolase
A1D75_RS11395	COG2894	cell division
A1D75_RS11405	COG3468	outer membrane autotransporter barrel domain protein
A1D75_RS11420	COG4571	Outer membrane protease
A1D75_RS11435	COG4372	Transposase
A1D75_RS11440	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS11455	COG0500	methyltransferase
A1D75_RS11465	COG3729	General stress protein
A1D75_RS11470	COG3685	Protein conserved in bacteria
A1D75_RS11475	COG3685	Protein conserved in bacteria
A1D75_RS11480	COG3546	catalase activity
A1D75_RS11485	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A1D75_RS11490	COG5301	cellulose 1,4-beta-cellobiosidase activity
A1D75_RS11525	COG1196	nuclear chromosome segregation
A1D75_RS11575	COG1030	water channel activity
A1D75_RS11595	COG4220	transposase activity
A1D75_RS11610	COG5562	phage envelope protein
A1D75_RS11650	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A1D75_RS11675	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A1D75_RS11685	COG2076	Multidrug Resistance protein
A1D75_RS11710	COG0582	viral genome integration into host DNA
A1D75_RS11715	COG0538	isocitrate dehydrogenase activity
A1D75_RS11720	COG1187	pseudouridine synthase activity
A1D75_RS11730	COG0482	sulfurtransferase activity
A1D75_RS11740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A1D75_RS11745	COG0745	RESPONSE REGULATOR receiver
A1D75_RS11750	COG2205	protein histidine kinase activity
A1D75_RS11765	COG1802	Transcriptional regulator
A1D75_RS11765	COG4626	Terminase
A1D75_RS11880	COG2850	peptidyl-arginine hydroxylation
A1D75_RS11890	COG3842	ATPase activity
A1D75_RS12100	COG3772	lysozyme
A1D75_RS12140	COG0484	heat shock protein binding
A1D75_RS12145	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A1D75_RS12150	COG1403	HNH endonuclease
A1D75_RS12205	COG1846	Transcriptional regulator
A1D75_RS12225	COG4197	protein conserved in bacteria, prophage-related
A1D75_RS12255	COG0582	viral genome integration into host DNA
A1D75_RS12260	COG1177	transmembrane transport
A1D75_RS12265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A1D75_RS12270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A1D75_RS12280	COG4591	ABC-type transport system involved in lipoprotein release permease component
A1D75_RS12285	COG1136	(ABC) transporter
A1D75_RS12290	COG4591	ABC-type transport system involved in lipoprotein release permease component
A1D75_RS12295	COG4763	Acyl-transferase
A1D75_RS12300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A1D75_RS12305	COG1388	LysM domain
A1D75_RS12305	COG1376	ErfK ybiS ycfS ynhG family protein
A1D75_RS12315	COG1309	transcriptional regulator
A1D75_RS12320	COG3134	Outer membrane lipoprotein
A1D75_RS12325	COG1252	NADH dehydrogenase
A1D75_RS12340	COG0510	thiamine kinase activity
A1D75_RS12345	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
A1D75_RS12350	COG5633	Lipoprotein
A1D75_RS12355	COG0537	adenosine 5'-monophosphoramidase activity
A1D75_RS12365	COG4773	Receptor
A1D75_RS12370	COG1263	PTS System
A1D75_RS12370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1D75_RS12375	COG0084	hydrolase, TatD family'
A1D75_RS12380	COG0470	DNA polymerase III
A1D75_RS12390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A1D75_RS12395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A1D75_RS12400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1D75_RS12410	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS12415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A1D75_RS12435	COG1399	metal-binding, possibly nucleic acid-binding protein
A1D75_RS12440	COG0424	maF-like protein
A1D75_RS12445	COG0564	pseudouridine synthase activity
A1D75_RS12455	COG1530	ribonuclease E activity
A1D75_RS12460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A1D75_RS12465	COG1256	bacterial-type flagellum assembly
A1D75_RS12470	COG1705	Flagellar rod assembly protein muramidase FlgJ
A1D75_RS12470	COG3951	Flagellar rod assembly protein muramidase FlgJ
A1D75_RS12485	COG4786	Flagellar basal body rod
A1D75_RS12490	COG4787	bacterial-type flagellum-dependent cell motility
A1D75_RS12495	COG1749	Flagellar hook protein flgE
A1D75_RS12500	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A1D75_RS12505	COG1558	bacterial-type flagellum-dependent cell motility
A1D75_RS12510	COG1815	bacterial-type flagellum-dependent cell motility
A1D75_RS12515	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
A1D75_RS12520	COG2747	anti-sigma28 factor FlgM
A1D75_RS12525	COG3418	PFAM FlgN family protein
A1D75_RS12530	COG0728	peptidoglycan biosynthetic process
A1D75_RS12535	COG0673	inositol 2-dehydrogenase activity
A1D75_RS12545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A1D75_RS12555	COG2999	glutathione oxidoreductase activity
A1D75_RS12590	COG3038	cytochrome b561
A1D75_RS12595	COG2353	YceI-like domain
A1D75_RS12605	COG1560	Kdo2-lipid A biosynthetic process
A1D75_RS12620	COG5645	(Lipo)protein
A1D75_RS12625	COG2943	transferase activity, transferring hexosyl groups
A1D75_RS12640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A1D75_RS12645	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A1D75_RS12670	COG2197	response regulator
A1D75_RS12685	COG1462	curli production assembly transport component CsgG
A1D75_RS12695	COG3381	protein complex oligomerization
A1D75_RS12760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1D75_RS12765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A1D75_RS12775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A1D75_RS12785	COG0736	holo-[acyl-carrier-protein] synthase activity
A1D75_RS12790	COG2831	hemolysin activation secretion protein
A1D75_RS12795	COG3210	domain, Protein
A1D75_RS12805	COG3539	Fimbrial protein
A1D75_RS12815	COG3188	usher protein
A1D75_RS12825	COG3121	Chaperone
A1D75_RS12830	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS12835	COG3710	Transcriptional regulator
A1D75_RS12845	COG2200	EAL domain
A1D75_RS12850	COG3706	GGDEF domain
A1D75_RS12855	COG0457	Tetratricopeptide repeat
A1D75_RS12860	COG1649	PFAM Uncharacterised BCR, COG1649
A1D75_RS12860	COG0726	polysaccharide deacetylase
A1D75_RS12865	COG1215	transferase activity, transferring glycosyl groups
A1D75_RS12870	COG3658	cytochrome
A1D75_RS12875	COG1702	phosphate starvation-inducible protein PhoH
A1D75_RS12880	COG2837	iron assimilation
A1D75_RS12885	COG2822	iron ion transport
A1D75_RS12900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A1D75_RS12910	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A1D75_RS12910	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A1D75_RS12910	COG0506	proline dehydrogenase activity
A1D75_RS12915	COG1309	transcriptional regulator
A1D75_RS12955	COG2233	PERMEase
A1D75_RS12960	COG3729	General stress protein
A1D75_RS12975	COG3561	AntA/AntB antirepressor
A1D75_RS13015	COG3111	PFAM Bacterial OB fold (BOF) protein
A1D75_RS13175	COG3772	lysozyme
A1D75_RS13325	COG4680	protein conserved in bacteria
A1D75_RS13465	COG0582	viral genome integration into host DNA
A1D75_RS13505	COG0243	molybdopterin cofactor binding
A1D75_RS13510	COG3005	denitrification pathway
A1D75_RS13515	COG0745	RESPONSE REGULATOR receiver
A1D75_RS13520	COG1879	ABC-type sugar transport system periplasmic component
A1D75_RS13525	COG2198	Histidine kinase
A1D75_RS13525	COG2205	protein histidine kinase activity
A1D75_RS13525	COG0784	Response regulator, receiver
A1D75_RS13530	COG0348	domain, Protein
A1D75_RS13550	COG1278	Cold shock
A1D75_RS13555	COG1278	Cold shock
A1D75_RS13575	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A1D75_RS13580	COG1596	polysaccharide export
A1D75_RS13585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A1D75_RS13590	COG3206	protein involved in exopolysaccharide biosynthesis
A1D75_RS13590	COG0489	protein tyrosine kinase activity
A1D75_RS13605	COG1294	oxidase, subunit
A1D75_RS13610	COG1271	oxidase subunit
A1D75_RS13615	COG1773	rubredoxin
A1D75_RS13620	COG1999	signal sequence binding
A1D75_RS13625	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A1D75_RS13630	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
A1D75_RS13635	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A1D75_RS13640	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A1D75_RS13665	COG5301	cellulose 1,4-beta-cellobiosidase activity
A1D75_RS13680	COG2032	superoxide dismutase activity
A1D75_RS13765	COG4220	transposase activity
A1D75_RS13770	COG4372	Transposase
A1D75_RS13775	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS13810	COG3772	lysozyme
A1D75_RS13870	COG2207	Transcriptional regulator
A1D75_RS13890	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A1D75_RS13895	COG1403	HNH endonuclease
A1D75_RS13930	COG1846	Transcriptional regulator
A1D75_RS13935	COG1484	DNA-dependent DNA replication
A1D75_RS14010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1D75_RS14030	COG0670	Belongs to the BI1 family
A1D75_RS14035	COG2920	part of a sulfur-relay system
A1D75_RS14040	COG1254	Belongs to the acylphosphatase family
A1D75_RS14055	COG1832	CoA-binding protein
A1D75_RS14070	COG0210	DNA helicase
A1D75_RS14075	COG3304	Inner membrane component domain
A1D75_RS14080	COG1289	transmembrane transporter activity
A1D75_RS14085	COG3070	regulator of competence-specific genes
A1D75_RS14095	COG2885	chlorophyll binding
A1D75_RS14095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A1D75_RS14105	COG1067	ATP-dependent peptidase activity
A1D75_RS14115	COG3130	regulation of translation
A1D75_RS14120	COG3009	Protein conserved in bacteria
A1D75_RS14125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A1D75_RS14125	COG3008	intermembrane lipid transfer
A1D75_RS14130	COG2995	paraquat-inducible protein a
A1D75_RS14135	COG0488	(ABC) transporter
A1D75_RS14145	COG0633	Ferredoxin
A1D75_RS14145	COG3217	Mosc domain protein beta barrel domain protein
A1D75_RS14165	COG3539	Fimbrial protein
A1D75_RS14170	COG3539	Fimbrial protein
A1D75_RS14180	COG3539	Fimbrial protein
A1D75_RS14190	COG3121	Chaperone
A1D75_RS14195	COG3539	Fimbrial protein
A1D75_RS14200	COG0431	NADPH-dependent FMN reductase
A1D75_RS14205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A1D75_RS14215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A1D75_RS14220	COG1116	anion transmembrane transporter activity
A1D75_RS14225	COG0308	aminopeptidase N
A1D75_RS14235	COG0017	Asparaginyl-tRNA synthetase
A1D75_RS14245	COG1448	Aminotransferase
A1D75_RS14250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1D75_RS14255	COG3108	Peptidase M15
A1D75_RS14260	COG2989	Protein conserved in bacteria
A1D75_RS14270	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A1D75_RS14280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A1D75_RS14285	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A1D75_RS14290	COG3173	Aminoglycoside phosphotransferase
A1D75_RS14305	COG3214	Protein conserved in bacteria
A1D75_RS14315	COG1132	(ABC) transporter
A1D75_RS14320	COG0658	competence protein
A1D75_RS14320	COG2333	competence protein COMEC
A1D75_RS14330	COG0539	negative regulation of cytoplasmic translation
A1D75_RS14340	COG0501	Belongs to the peptidase M48B family
A1D75_RS14355	COG2323	membrane
A1D75_RS14360	COG1944	ATP diphosphatase activity
A1D75_RS14365	COG2116	formate transmembrane transporter activity
A1D75_RS14370	COG1882	Formate acetyltransferase
A1D75_RS14375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A1D75_RS14385	COG0531	amino acid
A1D75_RS14395	COG1335	isochorismatase
A1D75_RS14400	COG3302	dmso reductase anchor subunit
A1D75_RS14405	COG0437	4 iron, 4 sulfur cluster binding
A1D75_RS14410	COG0243	molybdopterin cofactor binding
A1D75_RS14420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A1D75_RS14430	COG1674	ftsk spoiiie
A1D75_RS14430	COG1178	ABC-type Fe3 transport system permease component
A1D75_RS14435	COG1522	sequence-specific DNA binding
A1D75_RS14440	COG0492	ferredoxin-NADP+ reductase activity
A1D75_RS14445	COG4988	ABC transporter
A1D75_RS14450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A1D75_RS14500	COG2003	Belongs to the UPF0758 family
A1D75_RS14535	COG3468	outer membrane autotransporter barrel domain protein
A1D75_RS14590	COG1475	DNA binding
A1D75_RS14595	COG3969	phosphoadenosine phosphosulfate
A1D75_RS14600	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A1D75_RS14610	COG2831	hemolysin activation secretion protein
A1D75_RS14715	COG4771	TonB-dependent receptor
A1D75_RS14780	COG1358	cellular component organization or biogenesis
A1D75_RS14820	COG4372	Transposase
A1D75_RS14825	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS14870	COG0254	rRNA binding
A1D75_RS14915	COG0829	nickel cation binding
A1D75_RS14925	COG2194	sulfuric ester hydrolase activity
A1D75_RS14930	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A1D75_RS14975	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS14980	COG4372	Transposase
A1D75_RS15005	COG4983	Phage plasmid primase, P4 family domain protein
A1D75_RS15035	COG0582	viral genome integration into host DNA
A1D75_RS15040	COG0542	response to heat
A1D75_RS15050	COG1278	Cold shock
A1D75_RS15055	COG0577	efflux transmembrane transporter activity
A1D75_RS15055	COG1136	(ABC) transporter
A1D75_RS15060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1D75_RS15065	COG2990	Protein conserved in bacteria
A1D75_RS15070	COG3593	DNA synthesis involved in DNA repair
A1D75_RS15075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A1D75_RS15085	COG2431	L-lysine efflux transmembrane transporter activity
A1D75_RS15095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1D75_RS15100	COG0028	Belongs to the TPP enzyme family
A1D75_RS15105	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A1D75_RS15110	COG0702	epimerase
A1D75_RS15115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1D75_RS15120	COG3023	N-Acetylmuramoyl-L-alanine amidase
A1D75_RS15155	COG1126	abc transporter atp-binding protein
A1D75_RS15160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1D75_RS15165	COG4215	(ABC) transporter
A1D75_RS15170	COG4160	amino acid transport
A1D75_RS15175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1D75_RS15205	COG1177	transmembrane transport
A1D75_RS15210	COG1176	ABC-type spermidine putrescine transport system, permease component I
A1D75_RS15215	COG3842	ATPase activity
A1D75_RS15220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A1D75_RS15235	COG0778	Nitroreductase
A1D75_RS15245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A1D75_RS15260	COG3226	Transcriptional regulator
A1D75_RS15265	COG0738	Major facilitator superfamily
A1D75_RS15270	COG0561	phosphatase activity
A1D75_RS15280	COG2814	Major facilitator Superfamily
A1D75_RS15285	COG0671	phosphoesterase, PA-phosphatase related
A1D75_RS15290	COG1349	DNA-binding transcription factor activity
A1D75_RS15295	COG1686	Belongs to the peptidase S11 family
A1D75_RS15300	COG0625	glutathione transferase activity
A1D75_RS15305	COG2133	pyrroloquinoline quinone binding
A1D75_RS15330	COG2199	diguanylate cyclase activity
A1D75_RS15335	COG2200	EAL domain
A1D75_RS15345	COG0601	transmembrane transport
A1D75_RS15350	COG0747	negative chemotaxis
A1D75_RS15355	COG4172	Belongs to the ABC transporter superfamily
A1D75_RS15365	COG0303	'Molybdopterin
A1D75_RS15370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A1D75_RS15375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A1D75_RS15380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A1D75_RS15390	COG0561	phosphatase activity
A1D75_RS15400	COG0488	(ABC) transporter
A1D75_RS15405	COG1376	ErfK ybiS ycfS ynhG family protein
A1D75_RS15410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A1D75_RS15415	COG1321	iron dependent repressor
A1D75_RS15425	COG2194	sulfuric ester hydrolase activity
A1D75_RS15430	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A1D75_RS15440	COG5006	permease, DMT superfamily
A1D75_RS15450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1D75_RS15455	COG0765	amino acid transport
A1D75_RS15460	COG1126	abc transporter atp-binding protein
A1D75_RS15465	COG0668	transmembrane transport
A1D75_RS15480	COG4774	siderophore transport
A1D75_RS15490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A1D75_RS15500	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A1D75_RS15505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A1D75_RS15510	COG1199	ATP-dependent helicase activity
A1D75_RS15520	COG0513	Belongs to the DEAD box helicase family
A1D75_RS15525	COG1309	transcriptional regulator
A1D75_RS15535	COG1131	(ABC) transporter
A1D75_RS15540	COG0842	Transport permease protein
A1D75_RS15545	COG0842	Transport permease protein
A1D75_RS15555	COG3568	Endonuclease Exonuclease Phosphatase
A1D75_RS15560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A1D75_RS15565	COG0392	lysyltransferase activity
A1D75_RS15570	COG0670	Belongs to the BI1 family
A1D75_RS15575	COG0670	Belongs to the BI1 family
A1D75_RS15580	COG0314	molybdopterin synthase activity
A1D75_RS15585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A1D75_RS15595	COG0521	Mo-molybdopterin cofactor biosynthetic process
A1D75_RS15605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A1D75_RS15615	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A1D75_RS15620	COG2226	methyltransferase
A1D75_RS15635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A1D75_RS15640	COG1881	PFAM PEBP family protein
A1D75_RS15685	COG5301	cellulose 1,4-beta-cellobiosidase activity
A1D75_RS15760	COG0740	serine-type endopeptidase activity
A1D75_RS15805	COG3772	lysozyme
A1D75_RS15920	COG0582	viral genome integration into host DNA
A1D75_RS15925	COG4677	pectinesterase activity
A1D75_RS15930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A1D75_RS15935	COG0471	metal ion transport
A1D75_RS15940	COG2828	Protein conserved in bacteria
A1D75_RS15945	COG0583	DNA-binding transcription factor activity
A1D75_RS15955	COG0561	phosphatase activity
A1D75_RS15965	COG4149	molybdate abc transporter
A1D75_RS15970	COG0725	ABC transporter, periplasmic molybdate-binding protein
A1D75_RS15980	COG2005	Transcriptional regulator
A1D75_RS15980	COG3585	molybdate ion transport
A1D75_RS15985	COG1119	ATPase activity
A1D75_RS15990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A1D75_RS15995	COG1085	galactose-1-phosphate uridylyltransferase
A1D75_RS16005	COG2017	converts alpha-aldose to the beta-anomer
A1D75_RS16015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A1D75_RS16025	COG1230	cation diffusion facilitator family transporter
A1D75_RS16030	COG3201	nicotinamide mononucleotide transporter
A1D75_RS16035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A1D75_RS16070	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A1D75_RS16075	COG2885	chlorophyll binding
A1D75_RS16085	COG3064	Membrane
A1D75_RS16090	COG0848	biopolymer transport protein
A1D75_RS16095	COG0811	peptide transport
A1D75_RS16100	COG0824	Thioesterase
A1D75_RS16105	COG3790	cyd operon protein YbgE
A1D75_RS16110	COG4890	Cyd operon protein YbgT
A1D75_RS16115	COG1294	oxidase, subunit
A1D75_RS16120	COG1271	oxidase subunit
A1D75_RS16135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A1D75_RS16145	COG4865	methylaspartate mutase activity
A1D75_RS16150	COG3799	methylaspartate ammonia-lyase activity
A1D75_RS16165	COG1301	dicarboxylic acid transport
A1D75_RS16170	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A1D75_RS16170	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A1D75_RS16175	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A1D75_RS16180	COG0583	DNA-binding transcription factor activity
A1D75_RS16195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A1D75_RS16205	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1D75_RS16210	COG0567	Dehydrogenase, E1 component
A1D75_RS16215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A1D75_RS16220	COG1053	succinate dehydrogenase
A1D75_RS16225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A1D75_RS16230	COG2009	succinate dehydrogenase
A1D75_RS16240	COG0372	Belongs to the citrate synthase family
A1D75_RS16245	COG3539	Fimbrial protein
A1D75_RS16250	COG3188	usher protein
A1D75_RS16255	COG3188	usher protein
A1D75_RS16260	COG3121	Chaperone
A1D75_RS16265	COG3539	Fimbrial protein
A1D75_RS16270	COG3180	Ammonia monooxygenase
A1D75_RS16275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A1D75_RS16285	COG1984	allophanate hydrolase subunit 2
A1D75_RS16290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A1D75_RS16295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A1D75_RS16300	COG3104	oligopeptide transport
A1D75_RS16305	COG0415	Belongs to the DNA photolyase family
A1D75_RS16310	COG3272	Protein of unknown function (DUF1722)
A1D75_RS16340	COG3209	COG3209 Rhs family protein
A1D75_RS16370	COG2205	protein histidine kinase activity
A1D75_RS16375	COG0745	RESPONSE REGULATOR receiver
A1D75_RS16390	COG1982	Orn Lys Arg decarboxylase major
A1D75_RS16395	COG0531	amino acid
A1D75_RS16400	COG0033	Phosphoglucomutase
A1D75_RS16405	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A1D75_RS16410	COG0596	Alpha beta hydrolase
A1D75_RS16420	COG0716	FMN binding
A1D75_RS16430	COG0735	belongs to the Fur family
A1D75_RS16455	COG2190	(PTS) system
A1D75_RS16455	COG1263	PTS System
A1D75_RS16455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1D75_RS16465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A1D75_RS16470	COG1846	Transcriptional regulator
A1D75_RS16470	COG1940	carbohydrate kinase activity
A1D75_RS16475	COG0647	UMP catabolic process
A1D75_RS16480	COG0367	asparagine synthase
A1D75_RS16520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1D75_RS16530	COG1702	phosphate starvation-inducible protein PhoH
A1D75_RS16540	COG4535	Mg2 and Co2 transporter CorC
A1D75_RS16545	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A1D75_RS16550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1D75_RS16555	COG0765	amino acid transport
A1D75_RS16560	COG0765	amino acid transport
A1D75_RS16565	COG1126	abc transporter atp-binding protein
A1D75_RS16575	COG0443	Heat shock 70 kDa protein
A1D75_RS16590	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A1D75_RS16595	COG2214	Heat shock protein DnaJ domain protein
A1D75_RS16610	COG2888	peptidyl-tyrosine sulfation
A1D75_RS16625	COG1466	dna polymerase III delta subunit
A1D75_RS16635	COG0406	alpha-ribazole phosphatase activity
A1D75_RS16640	COG0799	negative regulation of ribosome biogenesis
A1D75_RS16650	COG0768	penicillin binding
A1D75_RS16655	COG0772	Belongs to the SEDS family
A1D75_RS16660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A1D75_RS16665	COG1686	Belongs to the peptidase S11 family
A1D75_RS16680	COG0583	DNA-binding transcription factor activity
A1D75_RS16690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A1D75_RS16695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A1D75_RS16715	COG3069	C4-dicarboxylate transmembrane transporter activity
A1D75_RS16720	COG4565	transcriptional regulatory protein
A1D75_RS16725	COG3290	protein histidine kinase activity
A1D75_RS16730	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A1D75_RS16740	COG2301	Belongs to the HpcH HpaI aldolase family
A1D75_RS16745	COG3051	citrate lyase alpha subunit
A1D75_RS16755	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A1D75_RS16760	COG0471	metal ion transport
A1D75_RS16765	COG3719	Belongs to the RNase T2 family
A1D75_RS16770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A1D75_RS16775	COG1063	alcohol dehydrogenase
A1D75_RS16780	COG0589	response to stress
A1D75_RS16785	COG3634	alkyl hydroperoxide reductase activity
A1D75_RS16790	COG0450	alkyl hydroperoxide reductase
A1D75_RS16795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A1D75_RS16800	COG0583	DNA-binding transcription factor activity
A1D75_RS16805	COG3969	phosphoadenosine phosphosulfate
A1D75_RS16810	COG1475	DNA binding
A1D75_RS16815	COG0436	Aminotransferase
A1D75_RS16820	COG0371	Dehydrogenase
A1D75_RS16825	COG2879	small protein
A1D75_RS16830	COG1966	Carbon starvation protein
A1D75_RS16840	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS16845	COG3433	isochorismatase activity
A1D75_RS16845	COG1535	isochorismatase
A1D75_RS16850	COG1021	2,3-dihydroxybenzoate-AMP ligase
A1D75_RS16855	COG1169	isochorismate synthase
A1D75_RS16860	COG4592	Periplasmic binding protein
A1D75_RS16870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1D75_RS16875	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1D75_RS16880	COG1120	ATPase activity
A1D75_RS16885	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A1D75_RS16890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1D75_RS16890	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A1D75_RS16895	COG3251	PFAM MbtH domain protein
A1D75_RS16900	COG2382	esterase
A1D75_RS16905	COG4771	TonB-dependent receptor
A1D75_RS16910	COG2977	Belongs to the P-Pant transferase superfamily
A1D75_RS16945	COG2315	Protein conserved in bacteria
A1D75_RS16950	COG0778	Nitroreductase
A1D75_RS16955	COG0668	transmembrane transport
A1D75_RS16960	COG1113	amino acid transport
A1D75_RS16965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1D75_RS16970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1D75_RS16975	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1D75_RS16980	COG1538	Outer membrane efflux protein
A1D75_RS16985	COG0745	RESPONSE REGULATOR receiver
A1D75_RS16990	COG5002	protein histidine kinase activity
A1D75_RS17005	COG3209	COG3209 Rhs family protein
A1D75_RS17005	COG4104	PAAR repeat-containing protein
A1D75_RS17020	COG3209	COG3209 Rhs family protein
A1D75_RS17020	COG4104	PAAR repeat-containing protein
A1D75_RS17030	COG5433	transposase activity
A1D75_RS17035	COG1215	transferase activity, transferring glycosyl groups
A1D75_RS17040	COG4783	chaperone-mediated protein folding
A1D75_RS17050	COG2207	Transcriptional regulator
A1D75_RS17060	COG2197	response regulator
A1D75_RS17065	COG3539	Fimbrial protein
A1D75_RS17070	COG3539	Fimbrial protein
A1D75_RS17075	COG3188	usher protein
A1D75_RS17080	COG3121	Chaperone
A1D75_RS17085	COG3539	Fimbrial protein
A1D75_RS17095	COG2501	S4 domain
A1D75_RS17100	COG1988	membrane-bound metal-dependent
A1D75_RS17110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A1D75_RS17120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A1D75_RS17125	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A1D75_RS17130	COG0549	Belongs to the carbamate kinase family
A1D75_RS17140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A1D75_RS17145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A1D75_RS17150	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A1D75_RS17155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A1D75_RS17160	COG3257	ureidoglycine aminohydrolase activity
A1D75_RS17165	COG1929	Belongs to the glycerate kinase type-1 family
A1D75_RS17170	COG2233	PERMEase
A1D75_RS17180	COG1953	Uracil, thiamine, allantoin
A1D75_RS17185	COG2084	Dehydrogenase
A1D75_RS17190	COG3622	Belongs to the hyi family
A1D75_RS17195	COG3960	tartronate-semialdehyde synthase activity
A1D75_RS17200	COG1414	Transcriptional regulator
A1D75_RS17210	COG0583	DNA-binding transcription factor activity
A1D75_RS17230	COG3209	COG3209 Rhs family protein
A1D75_RS17235	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A1D75_RS17240	COG4181	ATPase activity
A1D75_RS17245	COG2755	lipolytic protein G-D-S-L family
A1D75_RS17250	COG0300	oxidoreductase activity
A1D75_RS17255	COG3118	belongs to the thioredoxin family
A1D75_RS17260	COG0390	transport system, permease component
A1D75_RS17265	COG4619	ABC transporter
A1D75_RS17270	COG0330	HflC and HflK could
A1D75_RS17275	COG1585	Membrane protein implicated in regulation of membrane protease activity
A1D75_RS17300	COG0789	Transcriptional regulator
A1D75_RS17355	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A1D75_RS17385	COG3299	homolog of phage Mu protein gp47
A1D75_RS17395	COG4384	Bacteriophage Mu Gp45 protein
A1D75_RS17420	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
A1D75_RS17430	COG4386	tail sheath protein
A1D75_RS17455	COG4397	Mu-like prophage major head subunit gpT
A1D75_RS17460	COG4388	Caudovirus prohead serine protease
A1D75_RS17465	COG5005	Phage virion morphogenesis
A1D75_RS17470	COG2369	cell adhesion
A1D75_RS17475	COG4383	Mu-like prophage protein gp29
A1D75_RS17480	COG4373	Mu-like prophage FluMu protein gp28
A1D75_RS17520	COG5566	PFAM Mor transcription activator
A1D75_RS17575	COG4396	Host-nuclease inhibitor protein Gam
A1D75_RS17605	COG2842	Transposition protein
A1D75_RS17630	COG3552	Protein containing von Willebrand factor type A (VWA) domain
A1D75_RS17645	COG4808	Protein conserved in bacteria
A1D75_RS17650	COG4807	Protein conserved in bacteria
A1D75_RS17655	COG3279	Response regulator of the LytR AlgR family
A1D75_RS17660	COG3275	phosphorelay sensor kinase activity
A1D75_RS17685	COG5301	cellulose 1,4-beta-cellobiosidase activity
A1D75_RS17775	COG0740	serine-type endopeptidase activity
A1D75_RS17805	COG0740	serine-type endopeptidase activity
A1D75_RS17865	COG0582	viral genome integration into host DNA
A1D75_RS17905	COG3772	lysozyme
A1D75_RS18150	COG0582	viral genome integration into host DNA
A1D75_RS18155	COG0789	Transcriptional regulator
A1D75_RS18165	COG1174	glycine betaine transport
A1D75_RS18170	COG1125	glycine betaine transport
A1D75_RS18175	COG1174	glycine betaine transport
A1D75_RS18180	COG1732	Glycine betaine
A1D75_RS18185	COG1472	Belongs to the glycosyl hydrolase 3 family
A1D75_RS18190	COG0277	FAD linked oxidase domain protein
A1D75_RS18195	COG1686	Belongs to the peptidase S11 family
A1D75_RS18205	COG0586	Pfam SNARE associated Golgi protein
A1D75_RS18210	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS18215	COG1538	Outer membrane efflux protein
A1D75_RS18225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A1D75_RS18230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1D75_RS18235	COG0625	glutathione transferase activity
A1D75_RS18250	COG2271	Major facilitator Superfamily
A1D75_RS18265	COG1346	cytolysis
A1D75_RS18275	COG2949	membrane
A1D75_RS18285	COG0493	'glutamate synthase
A1D75_RS18290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A1D75_RS18290	COG0167	dihydroorotate dehydrogenase activity
A1D75_RS18295	COG4211	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS18300	COG1129	ABC transporter
A1D75_RS18305	COG1879	ABC-type sugar transport system periplasmic component
A1D75_RS18310	COG1609	Transcriptional regulator
A1D75_RS18315	COG2311	Membrane
A1D75_RS18325	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A1D75_RS18330	COG4771	TonB-dependent receptor
A1D75_RS18340	COG0833	amino acid
A1D75_RS18345	COG0583	DNA-binding transcription factor activity
A1D75_RS18350	COG2855	membrane
A1D75_RS18360	COG1522	sequence-specific DNA binding
A1D75_RS18360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1D75_RS18365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A1D75_RS18375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A1D75_RS18380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A1D75_RS18385	COG2313	pseudouridylate synthase activity
A1D75_RS18390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1D75_RS18395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1D75_RS18395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1D75_RS18395	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A1D75_RS18400	COG1105	Belongs to the carbohydrate kinase PfkB family
A1D75_RS18405	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS18405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS18410	COG2814	Major facilitator Superfamily
A1D75_RS18425	COG0246	Mannitol dehydrogenase
A1D75_RS18430	COG0523	cobalamin synthesis protein
A1D75_RS18435	COG0671	phosphoesterase, PA-phosphatase related
A1D75_RS18440	COG0791	NLP P60 protein
A1D75_RS18445	COG2200	EAL domain
A1D75_RS18450	COG4166	transmembrane transport
A1D75_RS18455	COG4174	ABC transporter (Permease)
A1D75_RS18460	COG4239	(ABC) transporter, permease
A1D75_RS18465	COG4172	Belongs to the ABC transporter superfamily
A1D75_RS18475	COG2814	Major facilitator Superfamily
A1D75_RS18480	COG1187	pseudouridine synthase activity
A1D75_RS18485	COG1061	Type III restriction enzyme res subunit
A1D75_RS18505	COG3083	sulfuric ester hydrolase activity
A1D75_RS18515	COG3468	outer membrane autotransporter barrel domain protein
A1D75_RS18520	COG2197	response regulator
A1D75_RS18525	COG3088	subunit of a heme lyase
A1D75_RS18525	COG4235	cytochrome complex assembly
A1D75_RS18530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1D75_RS18535	COG1138	Cytochrome C-type biogenesis protein
A1D75_RS18545	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A1D75_RS18550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A1D75_RS18555	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A1D75_RS18560	COG4133	protoheme IX ABC transporter activity
A1D75_RS18565	COG3005	denitrification pathway
A1D75_RS18570	COG3043	anaerobic respiration
A1D75_RS18575	COG0348	domain, Protein
A1D75_RS18580	COG0437	4 iron, 4 sulfur cluster binding
A1D75_RS18590	COG3062	negative regulation of establishment of protein localization
A1D75_RS18595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1D75_RS18595	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1D75_RS18610	COG4615	Cyclic peptide transporter
A1D75_RS18615	COG3145	DNA-N1-methyladenine dioxygenase activity
A1D75_RS18620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A1D75_RS18620	COG2169	Transcriptional regulator
A1D75_RS18625	COG1477	protein flavinylation
A1D75_RS18630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A1D75_RS18635	COG2198	Histidine kinase
A1D75_RS18635	COG0642	Histidine kinase
A1D75_RS18640	COG2197	response regulator
A1D75_RS18645	COG2205	protein histidine kinase activity
A1D75_RS18645	COG0784	Response regulator, receiver
A1D75_RS18650	COG4676	Protein conserved in bacteria
A1D75_RS18660	COG2373	Large extracellular alpha-helical protein
A1D75_RS18665	COG3234	Protein of unknown function (DUF1175)
A1D75_RS18670	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
A1D75_RS18675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A1D75_RS18685	COG3468	outer membrane autotransporter barrel domain protein
A1D75_RS18690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A1D75_RS18695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A1D75_RS18700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1D75_RS18705	COG3642	lipopolysaccharide core region biosynthetic process
A1D75_RS18710	COG2814	Major facilitator Superfamily
A1D75_RS18715	COG0583	DNA-binding transcription factor activity
A1D75_RS18725	COG0584	glycerophosphoryl diester phosphodiesterase
A1D75_RS18730	COG2271	Major facilitator Superfamily
A1D75_RS18735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A1D75_RS18745	COG0247	lactate metabolic process
A1D75_RS18750	COG5464	transposase or invertase
A1D75_RS18755	COG3836	Belongs to the HpcH HpaI aldolase family
A1D75_RS18765	COG4948	Mandelate Racemase Muconate Lactonizing
A1D75_RS18770	COG1414	Transcriptional regulator
A1D75_RS18790	COG0406	alpha-ribazole phosphatase activity
A1D75_RS18835	COG0318	PFAM AMP-dependent synthetase and ligase
A1D75_RS18845	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A1D75_RS18860	COG1169	isochorismate synthase
A1D75_RS18865	COG4575	ribosome binding
A1D75_RS18870	COG2153	protein acetylation
A1D75_RS18875	COG1234	tRNA 3'-trailer cleavage
A1D75_RS18880	COG5160	protein modification by small protein removal
A1D75_RS18900	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1D75_RS18905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A1D75_RS18915	COG0839	Belongs to the complex I subunit 6 family
A1D75_RS18930	COG1034	ATP synthesis coupled electron transport
A1D75_RS18935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A1D75_RS18940	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A1D75_RS18960	COG0583	DNA-binding transcription factor activity
A1D75_RS18965	COG0436	Aminotransferase
A1D75_RS18975	COG0471	metal ion transport
A1D75_RS18975	COG0490	domain, Protein
A1D75_RS18980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A1D75_RS18995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A1D75_RS19000	COG0857	belongs to the CobB CobQ family
A1D75_RS19000	COG0280	phosphate acetyltransferase
A1D75_RS19005	COG1288	antiporter activity
A1D75_RS19010	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A1D75_RS19015	COG0622	Phosphoesterase
A1D75_RS19020	COG0625	glutathione transferase activity
A1D75_RS19025	COG0625	glutathione transferase activity
A1D75_RS19030	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A1D75_RS19035	COG1090	epimerase
A1D75_RS19040	COG5464	transposase or invertase
A1D75_RS19045	COG4598	ABC transporter
A1D75_RS19050	COG4160	amino acid transport
A1D75_RS19055	COG4215	(ABC) transporter
A1D75_RS19060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1D75_RS19065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1D75_RS19070	COG0163	prenyltransferase activity
A1D75_RS19075	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A1D75_RS19080	COG1286	toxin biosynthetic process
A1D75_RS19085	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A1D75_RS19090	COG0285	dihydrofolate synthase activity
A1D75_RS19100	COG0586	Pfam SNARE associated Golgi protein
A1D75_RS19110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A1D75_RS19125	COG2814	Major facilitator Superfamily
A1D75_RS19130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1D75_RS19135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A1D75_RS19135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A1D75_RS19145	COG3101	peptidyl-lysine hydroxylation
A1D75_RS19150	COG0730	response to heat
A1D75_RS19180	COG3539	Fimbrial protein
A1D75_RS19185	COG3539	Fimbrial protein
A1D75_RS19190	COG3539	Fimbrial protein
A1D75_RS19195	COG3121	Chaperone
A1D75_RS19200	COG3188	usher protein
A1D75_RS19205	COG3539	Fimbrial protein
A1D75_RS19210	COG2062	phosphohistidine phosphatase, SixA
A1D75_RS19215	COG1024	Enoyl-CoA hydratase
A1D75_RS19215	COG1250	3-hydroxyacyl-CoA dehydrogenase
A1D75_RS19225	COG3691	Protein conserved in bacteria
A1D75_RS19230	COG2067	long-chain fatty acid transport protein
A1D75_RS19245	COG2853	Lipoprotein
A1D75_RS19250	COG2116	formate transmembrane transporter activity
A1D75_RS19260	COG0582	viral genome integration into host DNA
A1D75_RS19335	COG0477	Major facilitator Superfamily
A1D75_RS19340	COG1566	PFAM secretion protein HlyD family protein
A1D75_RS19345	COG2197	response regulator
A1D75_RS19350	COG2198	Histidine kinase
A1D75_RS19350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1D75_RS19350	COG2205	protein histidine kinase activity
A1D75_RS19350	COG0784	Response regulator, receiver
A1D75_RS19360	COG0679	Auxin Efflux Carrier
A1D75_RS19365	COG0028	Belongs to the TPP enzyme family
A1D75_RS19390	COG1560	Kdo2-lipid A biosynthetic process
A1D75_RS19400	COG0436	Aminotransferase
A1D75_RS19405	COG3275	phosphorelay sensor kinase activity
A1D75_RS19410	COG3279	Response regulator of the LytR AlgR family
A1D75_RS19415	COG2207	Transcriptional regulator
A1D75_RS19420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS19420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A1D75_RS19420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS19425	COG1363	Peptidase, m42
A1D75_RS19430	COG0006	proline dipeptidase activity
A1D75_RS19435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1D75_RS19440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1D75_RS19465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A1D75_RS19470	COG2200	EAL domain
A1D75_RS19470	COG2199	diguanylate cyclase activity
A1D75_RS19485	COG3415	Transposase
A1D75_RS19490	COG3415	Transposase
A1D75_RS19495	COG0675	Transposase, IS605 OrfB family
A1D75_RS19540	COG0385	Bile acid
A1D75_RS19545	COG3530	Putative quorum-sensing-regulated virulence factor
A1D75_RS19565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A1D75_RS19570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS19575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A1D75_RS19580	COG2190	(PTS) system
A1D75_RS19595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A1D75_RS19600	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A1D75_RS19605	COG4208	sulfate ABC transporter
A1D75_RS19610	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A1D75_RS19615	COG4150	thiosulfate binding
A1D75_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS19635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1D75_RS19635	COG1263	PTS System
A1D75_RS19640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A1D75_RS19645	COG2837	iron assimilation
A1D75_RS19665	COG0860	N-Acetylmuramoyl-L-alanine amidase
A1D75_RS19675	COG2207	Transcriptional regulator
A1D75_RS19680	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A1D75_RS19685	COG4816	utilization protein
A1D75_RS19695	COG4303	Ethanolamine ammonia lyase large subunit
A1D75_RS19700	COG4819	ethanolamine utilization protein
A1D75_RS19705	COG3192	ethanolamine utilization protein
A1D75_RS19710	COG1454	alcohol dehydrogenase
A1D75_RS19715	COG4820	ethanolamine utilization protein (EutJ)
A1D75_RS19720	COG1012	belongs to the aldehyde dehydrogenase family
A1D75_RS19725	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A1D75_RS19730	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A1D75_RS19735	COG0280	phosphate acetyltransferase
A1D75_RS19740	COG4812	Cobalamin adenosyltransferase
A1D75_RS19745	COG4766	ethanolamine catabolic process
A1D75_RS19750	COG4917	ethanolamine utilization protein
A1D75_RS19755	COG4810	utilization protein
A1D75_RS19760	COG0280	phosphate acetyltransferase
A1D75_RS19760	COG0281	malic enzyme
A1D75_RS19765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A1D75_RS19770	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A1D75_RS19775	COG5342	invasion associated locus B
A1D75_RS19785	COG0493	'glutamate synthase
A1D75_RS19785	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1D75_RS19790	COG3850	Histidine kinase
A1D75_RS19795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1D75_RS19810	COG1393	Belongs to the ArsC family
A1D75_RS19825	COG0400	carboxylic ester hydrolase activity
A1D75_RS19835	COG2321	neutral zinc metallopeptidase
A1D75_RS19845	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A1D75_RS19855	COG2716	regulation of RNA biosynthetic process
A1D75_RS19860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A1D75_RS19865	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1D75_RS19870	COG0651	ATP synthesis coupled electron transport
A1D75_RS19875	COG0650	Formate hydrogenlyase subunit 4
A1D75_RS19880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A1D75_RS19885	COG4237	Hydrogenase 4 membrane
A1D75_RS19890	COG0651	ATP synthesis coupled electron transport
A1D75_RS19895	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A1D75_RS19895	COG3261	NADH dehydrogenase
A1D75_RS19900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1D75_RS19905	COG3260	NADH ubiquinone oxidoreductase 20
A1D75_RS19915	COG3604	Transcriptional regulator
A1D75_RS19920	COG2116	formate transmembrane transporter activity
A1D75_RS19925	COG0628	permease
A1D75_RS19930	COG4783	chaperone-mediated protein folding
A1D75_RS19935	COG1393	Belongs to the ArsC family
A1D75_RS19945	COG2233	PERMEase
A1D75_RS19960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A1D75_RS19965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A1D75_RS19970	COG0248	Ppx GppA phosphatase
A1D75_RS19975	COG2200	EAL domain
A1D75_RS19985	COG3133	Outer membrane lipoprotein
A1D75_RS20000	COG0516	GMP reductase activity
A1D75_RS20000	COG0517	IMP dehydrogenase activity
A1D75_RS20010	COG1645	bacterial-type flagellum-dependent swarming motility
A1D75_RS20025	COG2976	Protein conserved in bacteria
A1D75_RS20060	COG3302	dmso reductase anchor subunit
A1D75_RS20065	COG0437	4 iron, 4 sulfur cluster binding
A1D75_RS20070	COG0243	molybdopterin cofactor binding
A1D75_RS20075	COG4953	penicillin-binding protein 1C
A1D75_RS20080	COG2373	Large extracellular alpha-helical protein
A1D75_RS20085	COG2897	thiosulfate sulfurtransferase activity
A1D75_RS20100	COG2975	iron-sulfur cluster assembly
A1D75_RS20105	COG0633	Ferredoxin
A1D75_RS20125	COG0822	iron-sulfur transferase activity
A1D75_RS20145	COG0483	inositol monophosphate 1-phosphatase activity
A1D75_RS20150	COG1073	alpha beta
A1D75_RS20155	COG3711	transcriptional antiterminator
A1D75_RS20160	COG2814	Major facilitator Superfamily
A1D75_RS20165	COG0583	DNA-binding transcription factor activity
A1D75_RS20170	COG4638	Rieske (2fe-2S)
A1D75_RS20195	COG2259	Doxx family
A1D75_RS20200	COG2017	converts alpha-aldose to the beta-anomer
A1D75_RS20210	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS20215	COG1129	ABC transporter
A1D75_RS20220	COG1879	ABC-type sugar transport system periplasmic component
A1D75_RS20225	COG0457	Tetratricopeptide repeat
A1D75_RS20230	COG1940	carbohydrate kinase activity
A1D75_RS20240	COG1017	nitric oxide dioxygenase activity
A1D75_RS20240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1D75_RS20245	COG0347	Belongs to the P(II) protein family
A1D75_RS20250	COG2204	response regulator
A1D75_RS20255	COG3170	Tfp pilus assembly protein FimV
A1D75_RS20260	COG2205	protein histidine kinase activity
A1D75_RS20265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A1D75_RS20265	COG0047	phosphoribosylformylglycinamidine synthase activity
A1D75_RS20270	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A1D75_RS20275	COG0590	tRNA wobble adenosine to inosine editing
A1D75_RS20280	COG0560	Phosphoserine phosphatase
A1D75_RS20285	COG1737	Transcriptional regulator
A1D75_RS20290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1D75_RS20305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A1D75_RS20325	COG0681	Belongs to the peptidase S26 family
A1D75_RS20335	COG3086	response to oxidative stress
A1D75_RS20340	COG3026	antisigma factor binding
A1D75_RS20345	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A1D75_RS20350	COG1595	DNA-templated transcription, initiation
A1D75_RS20360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A1D75_RS20365	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A1D75_RS20370	COG0513	Belongs to the DEAD box helicase family
A1D75_RS20375	COG0583	DNA-binding transcription factor activity
A1D75_RS20380	COG1280	lysine exporter protein (LysE YggA)
A1D75_RS20395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1D75_RS20400	COG3118	belongs to the thioredoxin family
A1D75_RS20405	COG3148	PFAM DTW domain containing protein
A1D75_RS20410	COG0045	succinate-CoA ligase (ADP-forming) activity
A1D75_RS20410	COG1042	CoA-binding domain protein
A1D75_RS20410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A1D75_RS20415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A1D75_RS20420	COG5544	Lipoprotein
A1D75_RS20425	COG0477	Major facilitator Superfamily
A1D75_RS20450	COG0542	response to heat
A1D75_RS20460	COG0564	pseudouridine synthase activity
A1D75_RS20465	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A1D75_RS20470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A1D75_RS20480	COG0077	Prephenate dehydratase
A1D75_RS20480	COG1605	Chorismate mutase
A1D75_RS20485	COG0287	Prephenate dehydrogenase
A1D75_RS20485	COG1605	Chorismate mutase
A1D75_RS20490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A1D75_RS20505	COG2199	diguanylate cyclase activity
A1D75_RS20510	COG2885	chlorophyll binding
A1D75_RS20535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A1D75_RS20540	COG4137	Cytochrome C assembly protein
A1D75_RS20545	COG4536	flavin adenine dinucleotide binding
A1D75_RS20565	COG0497	DNA recombination
A1D75_RS20570	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A1D75_RS20580	COG2867	negative regulation of translational initiation
A1D75_RS20605	COG0727	PFAM Uncharacterised protein family (UPF0153)
A1D75_RS20655	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS20665	COG3772	lysozyme
A1D75_RS20715	COG2826	transposase and inactivated derivatives, IS30 family
A1D75_RS20765	COG3468	outer membrane autotransporter barrel domain protein
A1D75_RS20805	COG0579	oxidoreductase
A1D75_RS20810	COG1012	belongs to the aldehyde dehydrogenase family
A1D75_RS20815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A1D75_RS20820	COG1113	amino acid transport
A1D75_RS20825	COG1802	Transcriptional regulator
A1D75_RS20830	COG1652	LysM domain
A1D75_RS20835	COG0401	homolog of Blt101
A1D75_RS20840	COG0640	Transcriptional regulator
A1D75_RS20845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A1D75_RS20850	COG2916	Histone family protein nucleoid-structuring protein H-NS
A1D75_RS20865	COG4575	ribosome binding
A1D75_RS20875	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A1D75_RS20885	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A1D75_RS20895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A1D75_RS20900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A1D75_RS20910	COG4175	Glycine betaine
A1D75_RS20915	COG4176	ABC-type proline glycine betaine transport system permease component
A1D75_RS20920	COG2113	Glycine betaine
A1D75_RS20925	COG2814	Major facilitator Superfamily
A1D75_RS20930	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A1D75_RS20940	COG1846	Transcriptional regulator
A1D75_RS20945	COG1566	PFAM secretion protein HlyD family protein
A1D75_RS20950	COG2814	Major facilitator Superfamily
A1D75_RS20965	COG1238	metal cluster binding
A1D75_RS20970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A1D75_RS21000	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A1D75_RS21005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A1D75_RS21020	COG1546	Belongs to the CinA family
A1D75_RS21025	COG2951	lytic endotransglycosylase activity
A1D75_RS21045	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS21050	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS21055	COG1349	DNA-binding transcription factor activity
A1D75_RS21060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A1D75_RS21060	COG0517	IMP dehydrogenase activity
A1D75_RS21070	COG1773	rubredoxin
A1D75_RS21070	COG0426	domain, Protein
A1D75_RS21080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A1D75_RS21085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1D75_RS21090	COG1609	Transcriptional regulator
A1D75_RS21095	COG1263	PTS System
A1D75_RS21095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1D75_RS21100	COG2723	6-phospho-beta-galactosidase activity
A1D75_RS21105	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A1D75_RS21115	COG3260	NADH ubiquinone oxidoreductase 20
A1D75_RS21120	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1D75_RS21125	COG3261	NADH dehydrogenase
A1D75_RS21125	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A1D75_RS21130	COG0650	Formate hydrogenlyase subunit 4
A1D75_RS21135	COG0651	ATP synthesis coupled electron transport
A1D75_RS21140	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1D75_RS21150	COG0375	protein maturation
A1D75_RS21155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A1D75_RS21160	COG0298	carbon dioxide binding
A1D75_RS21165	COG0409	Hydrogenase expression formation protein
A1D75_RS21170	COG0309	Hydrogenase expression formation protein (HypE)
A1D75_RS21175	COG3604	Transcriptional regulator
A1D75_RS21190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A1D75_RS21200	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A1D75_RS21205	COG0163	prenyltransferase activity
A1D75_RS21210	COG1846	Transcriptional regulator
A1D75_RS21215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A1D75_RS21220	COG1388	LysM domain
A1D75_RS21220	COG4942	peptidase
A1D75_RS21275	COG2234	aminopeptidase activity
A1D75_RS21280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1D75_RS21285	COG1518	maintenance of DNA repeat elements
A1D75_RS21300	COG1857	crispr-associated protein
A1D75_RS21315	COG1203	CRISPR-associated helicase, Cas3
A1D75_RS21340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A1D75_RS21345	COG0720	synthase
A1D75_RS21350	COG0644	oxidoreductase
A1D75_RS21355	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A1D75_RS21360	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A1D75_RS21370	COG2086	electron transfer activity
A1D75_RS21380	COG0277	FAD linked oxidase domain protein
A1D75_RS21385	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS21390	COG2223	nitrite transmembrane transporter activity
A1D75_RS21395	COG1070	Carbohydrate kinase
A1D75_RS21400	COG0602	queuosine metabolic process
A1D75_RS21410	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A1D75_RS21420	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A1D75_RS21435	COG3956	TIGRFAM MazG family protein
A1D75_RS21440	COG2337	Toxic component of a toxin-antitoxin (TA) module
A1D75_RS21445	COG2336	PFAM SpoVT AbrB
A1D75_RS21450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A1D75_RS21455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A1D75_RS21460	COG4999	Histidine kinase
A1D75_RS21460	COG2205	protein histidine kinase activity
A1D75_RS21460	COG3437	response regulator, receiver
A1D75_RS21460	COG3850	Histidine kinase
A1D75_RS21465	COG4948	Mandelate Racemase Muconate Lactonizing
A1D75_RS21470	COG4948	Mandelate Racemase Muconate Lactonizing
A1D75_RS21475	COG4948	Mandelate Racemase Muconate Lactonizing
A1D75_RS21480	COG2271	Major facilitator Superfamily
A1D75_RS21485	COG0716	FMN binding
A1D75_RS21490	COG0564	pseudouridine synthase activity
A1D75_RS21495	COG3098	single-species biofilm formation
A1D75_RS21510	COG1611	Belongs to the LOG family
A1D75_RS21515	COG0814	amino acid
A1D75_RS21520	COG1760	l-serine dehydratase
A1D75_RS21530	COG1454	alcohol dehydrogenase
A1D75_RS21535	COG0235	Class ii aldolase
A1D75_RS21540	COG0738	Major facilitator superfamily
A1D75_RS21550	COG1070	Carbohydrate kinase
A1D75_RS21560	COG1349	DNA-binding transcription factor activity
A1D75_RS21570	COG2363	Small membrane protein
A1D75_RS21575	COG0583	DNA-binding transcription factor activity
A1D75_RS21585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A1D75_RS21590	COG2166	iron-sulfur cluster assembly
A1D75_RS21595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A1D75_RS21600	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A1D75_RS21620	COG0860	N-Acetylmuramoyl-L-alanine amidase
A1D75_RS21625	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A1D75_RS21625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A1D75_RS21630	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A1D75_RS21635	COG1074	ATP-dependent DNA helicase activity
A1D75_RS21640	COG1025	Belongs to the peptidase M16 family
A1D75_RS21645	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A1D75_RS21650	COG4967	type IV pilus modification protein PilV
A1D75_RS21660	COG4795	General secretion pathway protein
A1D75_RS21665	COG2165	general secretion pathway protein
A1D75_RS21680	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
A1D75_RS21700	COG0861	Integral membrane protein TerC family
A1D75_RS21710	COG0667	Aldo Keto reductase
A1D75_RS21725	COG1609	Transcriptional regulator
A1D75_RS21735	COG0583	DNA-binding transcription factor activity
A1D75_RS21740	COG1794	racemase activity, acting on amino acids and derivatives
A1D75_RS21745	COG2814	Major facilitator Superfamily
A1D75_RS21750	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS21760	COG0183	Belongs to the thiolase family
A1D75_RS21765	COG0814	amino acid
A1D75_RS21770	COG2771	luxR family
A1D75_RS21775	COG3710	Transcriptional regulator
A1D75_RS21800	COG0457	Tetratricopeptide repeat
A1D75_RS21810	COG0457	Tetratricopeptide repeat
A1D75_RS21810	COG3710	Transcriptional regulator
A1D75_RS21820	COG0741	lytic transglycosylase activity
A1D75_RS21825	COG2197	response regulator
A1D75_RS21940	COG2207	Transcriptional regulator
A1D75_RS21960	COG4942	peptidase
A1D75_RS21965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A1D75_RS21970	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A1D75_RS21975	COG2080	2 iron, 2 sulfur cluster binding
A1D75_RS21980	COG3829	transcription factor binding
A1D75_RS21985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A1D75_RS21990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A1D75_RS21995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A1D75_RS22005	COG0549	Belongs to the carbamate kinase family
A1D75_RS22010	COG3608	succinylglutamate desuccinylase aspartoacylase
A1D75_RS22010	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A1D75_RS22015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A1D75_RS22020	COG2068	MobA-Related Protein
A1D75_RS22025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1D75_RS22025	COG0493	'glutamate synthase
A1D75_RS22030	COG0402	S-adenosylhomocysteine deaminase activity
A1D75_RS22035	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A1D75_RS22040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A1D75_RS22040	COG2080	2 iron, 2 sulfur cluster binding
A1D75_RS22045	COG2233	PERMEase
A1D75_RS22050	COG0402	S-adenosylhomocysteine deaminase activity
A1D75_RS22055	COG2252	PERMEase
A1D75_RS22065	COG0493	'glutamate synthase
A1D75_RS22065	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1D75_RS22070	COG2233	PERMEase
A1D75_RS22090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A1D75_RS22100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A1D75_RS22105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A1D75_RS22110	COG4974	Belongs to the 'phage' integrase family
A1D75_RS22115	COG0716	FMN binding
A1D75_RS22125	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A1D75_RS22135	COG1272	protein, Hemolysin III
A1D75_RS22145	COG2723	6-phospho-beta-galactosidase activity
A1D75_RS22170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1D75_RS22175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1D75_RS22180	COG0006	proline dipeptidase activity
A1D75_RS22200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A1D75_RS22215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A1D75_RS22230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A1D75_RS22230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A1D75_RS22235	COG1703	isobutyryl-CoA mutase activity
A1D75_RS22240	COG1024	Enoyl-CoA hydratase
A1D75_RS22245	COG0427	acetyl-CoA hydrolase
A1D75_RS22250	COG0583	DNA-binding transcription factor activity
A1D75_RS22255	COG0583	DNA-binding transcription factor activity
A1D75_RS22260	COG2968	Membrane
A1D75_RS22270	COG0668	transmembrane transport
A1D75_RS22275	COG0191	fructose-bisphosphate aldolase activity
A1D75_RS22280	COG0126	phosphoglycerate kinase activity
A1D75_RS22305	COG1122	ATPase activity
A1D75_RS22310	COG1122	ATPase activity
A1D75_RS22315	COG1072	(Pantothenic acid kinase))
A1D75_RS22325	COG1494	fructose-1,6-bisphosphatase
A1D75_RS22330	COG1063	alcohol dehydrogenase
A1D75_RS22335	COG2213	PTS system mannitol-specific
A1D75_RS22340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS22345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A1D75_RS22350	COG0501	Belongs to the peptidase M48B family
A1D75_RS22365	COG1166	arginine decarboxylase activity
A1D75_RS22390	COG2814	Major facilitator Superfamily
A1D75_RS22395	COG3091	SprT-like family
A1D75_RS22400	COG2356	endonuclease I
A1D75_RS22405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A1D75_RS22410	COG0189	ligase activity
A1D75_RS22425	COG2805	Type II/IV secretion system protein
A1D75_RS22430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A1D75_RS22435	COG0762	integral membrane protein
A1D75_RS22445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A1D75_RS22450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A1D75_RS22460	COG0252	asparaginase activity
A1D75_RS22470	COG3171	Protein conserved in bacteria
A1D75_RS22480	COG1194	a g-specific adenine glycosylase
A1D75_RS22495	COG2211	Major facilitator Superfamily
A1D75_RS22500	COG1982	Orn Lys Arg decarboxylase major
A1D75_RS22505	COG1811	Na channel or pump
A1D75_RS22515	COG0582	viral genome integration into host DNA
A1D75_RS22535	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS22620	COG1451	nucleotide metabolic process
A1D75_RS22630	COG4680	protein conserved in bacteria
A1D75_RS22635	COG5499	transcription regulator containing HTH domain
A1D75_RS22640	COG0446	pyridine nucleotide-disulphide oxidoreductase
A1D75_RS22640	COG1902	pentaerythritol trinitrate reductase activity
A1D75_RS22645	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
A1D75_RS22645	COG3408	Glycogen debranching enzyme
A1D75_RS22655	COG0531	amino acid
A1D75_RS22660	COG2731	YhcH YjgK YiaL family protein
A1D75_RS22665	COG3250	beta-galactosidase activity
A1D75_RS22670	COG1609	Transcriptional regulator
A1D75_RS22675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1D75_RS22685	COG0840	transmembrane signaling receptor activity
A1D75_RS22690	COG1695	Transcriptional regulator
A1D75_RS22695	COG2375	cellular response to nickel ion
A1D75_RS22710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A1D75_RS22715	COG0358	DNA primase activity
A1D75_RS22720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A1D75_RS22725	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A1D75_RS22730	COG0471	metal ion transport
A1D75_RS22735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A1D75_RS22740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A1D75_RS22745	COG0583	DNA-binding transcription factor activity
A1D75_RS22755	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A1D75_RS22770	COG4991	sh3 domain protein
A1D75_RS22775	COG3025	triphosphatase activity
A1D75_RS22800	COG2268	Band 7 protein
A1D75_RS22805	COG1585	Membrane protein implicated in regulation of membrane protease activity
A1D75_RS22830	COG3384	dioxygenase
A1D75_RS22835	COG0754	glutathionylspermidine amidase activity
A1D75_RS22845	COG1538	Outer membrane efflux protein
A1D75_RS22850	COG0494	nUDIX hydrolase
A1D75_RS22855	COG3151	Protein conserved in bacteria
A1D75_RS22860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A1D75_RS22865	COG3150	esterase
A1D75_RS22870	COG0187	DNA topoisomerase II activity
A1D75_RS22875	COG4774	siderophore transport
A1D75_RS22880	COG1120	ATPase activity
A1D75_RS22885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1D75_RS22890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1D75_RS22900	COG1737	Transcriptional regulator
A1D75_RS22905	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A1D75_RS22910	COG2249	NAD(P)H dehydrogenase (quinone) activity
A1D75_RS22915	COG0642	Histidine kinase
A1D75_RS22920	COG0745	RESPONSE REGULATOR receiver
A1D75_RS22925	COG3111	PFAM Bacterial OB fold (BOF) protein
A1D75_RS22930	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A1D75_RS22935	COG4166	transmembrane transport
A1D75_RS22940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A1D75_RS22945	COG0204	Acyl-transferase
A1D75_RS22950	COG2132	Multicopper oxidase
A1D75_RS22955	COG1032	radical SAM domain protein
A1D75_RS22960	COG4238	major outer membrane lipoprotein
A1D75_RS22970	COG0656	L-ascorbic acid biosynthetic process
A1D75_RS22975	COG1979	alcohol dehydrogenase
A1D75_RS22980	COG2207	Transcriptional regulator
A1D75_RS22985	COG0586	Pfam SNARE associated Golgi protein
A1D75_RS22990	COG0626	cystathionine gamma-synthase activity
A1D75_RS22995	COG0811	peptide transport
A1D75_RS23000	COG0848	biopolymer transport protein
A1D75_RS23005	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS23015	COG0667	Aldo Keto reductase
A1D75_RS23030	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A1D75_RS23035	COG0437	4 iron, 4 sulfur cluster binding
A1D75_RS23040	COG5557	Pfam Polysulphide reductase, NrfD
A1D75_RS23045	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A1D75_RS23050	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A1D75_RS23055	COG1773	rubredoxin
A1D75_RS23060	COG0375	protein maturation
A1D75_RS23065	COG0298	carbon dioxide binding
A1D75_RS23070	COG0625	glutathione transferase activity
A1D75_RS23075	COG0754	glutathionylspermidine amidase activity
A1D75_RS23100	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS23110	COG4372	Transposase
A1D75_RS23115	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS23130	COG1451	nucleotide metabolic process
A1D75_RS23135	COG2949	membrane
A1D75_RS23140	COG0673	inositol 2-dehydrogenase activity
A1D75_RS23145	COG0861	Integral membrane protein TerC family
A1D75_RS23150	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A1D75_RS23160	COG2721	sulfolactate sulfo-lyase activity
A1D75_RS23170	COG2271	Major facilitator Superfamily
A1D75_RS23175	COG2186	Transcriptional regulator
A1D75_RS23180	COG0586	Pfam SNARE associated Golgi protein
A1D75_RS23190	COG1422	Protein of unknown function (DUF1090)
A1D75_RS23195	COG4575	ribosome binding
A1D75_RS23200	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
A1D75_RS23210	COG2259	Doxx family
A1D75_RS23215	COG0435	Glutathione S-transferase
A1D75_RS23220	COG3152	Membrane
A1D75_RS23225	COG3152	Membrane
A1D75_RS23230	COG0583	DNA-binding transcription factor activity
A1D75_RS23235	COG1741	Belongs to the pirin family
A1D75_RS23250	COG0814	amino acid
A1D75_RS23255	COG1760	l-serine dehydratase
A1D75_RS23260	COG0251	oxidation-reduction process
A1D75_RS23265	COG1882	Formate acetyltransferase
A1D75_RS23270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A1D75_RS23280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A1D75_RS23285	COG0583	DNA-binding transcription factor activity
A1D75_RS23310	COG1929	Belongs to the glycerate kinase type-1 family
A1D75_RS23315	COG2084	Dehydrogenase
A1D75_RS23325	COG2271	Major facilitator Superfamily
A1D75_RS23330	COG2721	sulfolactate sulfo-lyase activity
A1D75_RS23335	COG2002	toxin-antitoxin pair type II binding
A1D75_RS23345	COG1349	DNA-binding transcription factor activity
A1D75_RS23355	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1D75_RS23365	COG3716	PTS system mannose fructose sorbose family IID component
A1D75_RS23370	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS23375	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A1D75_RS23380	COG2222	sugar isomerase
A1D75_RS23390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A1D75_RS23400	COG3716	PTS system mannose fructose sorbose family IID component
A1D75_RS23410	COG3539	Fimbrial protein
A1D75_RS23415	COG3121	Chaperone
A1D75_RS23420	COG3188	usher protein
A1D75_RS23425	COG3539	Fimbrial protein
A1D75_RS23430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A1D75_RS23450	COG2823	Periplasmic or secreted lipoprotein
A1D75_RS23455	COG0701	Predicted permease
A1D75_RS23460	COG0702	epimerase
A1D75_RS23465	COG0693	protein deglycase activity
A1D75_RS23470	COG3787	Belongs to the UPF0306 family
A1D75_RS23480	COG3153	acetyltransferase
A1D75_RS23485	COG3154	lipid carrier protein
A1D75_RS23490	COG0826	peptidase U32
A1D75_RS23495	COG0826	peptidase U32
A1D75_RS23500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A1D75_RS23505	COG0814	amino acid
A1D75_RS23510	COG0513	Belongs to the DEAD box helicase family
A1D75_RS23550	COG0195	Participates in both transcription termination and antitermination
A1D75_RS23570	COG2194	sulfuric ester hydrolase activity
A1D75_RS23580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A1D75_RS23590	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A1D75_RS23595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A1D75_RS23605	COG1534	Rna-binding protein
A1D75_RS23610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A1D75_RS23615	COG2027	D-alanyl-D-alanine carboxypeptidase
A1D75_RS23625	COG0697	spore germination
A1D75_RS23640	COG0142	geranyltranstransferase activity
A1D75_RS23645	COG3423	Transcriptional regulator
A1D75_RS23655	COG5007	Belongs to the BolA IbaG family
A1D75_RS23660	COG3113	response to antibiotic
A1D75_RS23665	COG2854	intermembrane phospholipid transfer
A1D75_RS23670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A1D75_RS23675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A1D75_RS23680	COG1127	ABC transporter
A1D75_RS23685	COG0530	calcium, potassium:sodium antiporter activity
A1D75_RS23690	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A1D75_RS23690	COG0517	IMP dehydrogenase activity
A1D75_RS23695	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A1D75_RS23700	COG3117	lipopolysaccharide transmembrane transporter activity
A1D75_RS23705	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A1D75_RS23710	COG1137	ATPase activity
A1D75_RS23715	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A1D75_RS23720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A1D75_RS23735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS23740	COG0515	serine threonine protein kinase
A1D75_RS23750	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A1D75_RS23755	COG0784	Response regulator, receiver
A1D75_RS23755	COG2198	Histidine kinase
A1D75_RS23755	COG5002	protein histidine kinase activity
A1D75_RS23760	COG1242	4 iron, 4 sulfur cluster binding
A1D75_RS23765	COG0070	glutamate synthase
A1D75_RS23765	COG0069	glutamate synthase activity
A1D75_RS23765	COG0067	glutamate synthase
A1D75_RS23770	COG0493	'glutamate synthase
A1D75_RS23775	COG4804	nuclease activity
A1D75_RS23780	COG2731	YhcH YjgK YiaL family protein
A1D75_RS23810	COG3069	C4-dicarboxylate transmembrane transporter activity
A1D75_RS23815	COG2969	positive regulation of protein catabolic process
A1D75_RS23820	COG0625	glutathione transferase activity
A1D75_RS23840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A1D75_RS23845	COG3105	Protein conserved in bacteria
A1D75_RS23850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1D75_RS23855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1D75_RS23875	COG2732	(Barnase) inhibitor
A1D75_RS23895	COG0583	DNA-binding transcription factor activity
A1D75_RS23900	COG0312	modulator of DNA gyrase
A1D75_RS23905	COG3164	Protein of unknown function
A1D75_RS23910	COG1530	ribonuclease E activity
A1D75_RS23915	COG0424	maF-like protein
A1D75_RS23920	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A1D75_RS23925	COG1792	Involved in formation and maintenance of cell shape
A1D75_RS23930	COG1077	Cell shape determining protein MreB Mrl
A1D75_RS23940	COG2200	EAL domain
A1D75_RS23940	COG2199	diguanylate cyclase activity
A1D75_RS23945	COG0604	alcohol dehydrogenase
A1D75_RS23950	COG0511	ligase activity, forming carbon-carbon bonds
A1D75_RS23955	COG0439	Biotin carboxylase
A1D75_RS23960	COG3924	membrane
A1D75_RS23965	COG4145	pantothenate transmembrane transporter activity
A1D75_RS23975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A1D75_RS23985	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A1D75_RS23995	COG1309	transcriptional regulator
A1D75_RS24000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1D75_RS24015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1D75_RS24020	COG4597	amino acid ABC transporter
A1D75_RS24025	COG0765	amino acid transport
A1D75_RS24030	COG1126	abc transporter atp-binding protein
A1D75_RS24070	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A1D75_RS24085	COG0009	L-threonylcarbamoyladenylate synthase
A1D75_RS24090	COG0551	DNA topoisomerase type I activity
A1D75_RS24100	COG0758	DNA mediated transformation
A1D75_RS24120	COG0569	domain protein
A1D75_RS24130	COG3036	rescue of stalled ribosome
A1D75_RS24135	COG0789	Transcriptional regulator
A1D75_RS24175	COG0201	protein transport
A1D75_RS24265	COG0089	rRNA binding
A1D75_RS24340	COG2964	Protein conserved in bacteria
A1D75_RS24345	COG0545	Peptidyl-prolyl cis-trans isomerase
A1D75_RS24355	COG1047	Peptidyl-prolyl cis-trans
A1D75_RS24360	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A1D75_RS24375	COG0488	(ABC) transporter
A1D75_RS24380	COG0429	hydrolase of the alpha beta-hydrolase fold
A1D75_RS24390	COG3954	Phosphoribulokinase
A1D75_RS24395	COG1765	OsmC-like protein
A1D75_RS24400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A1D75_RS24405	COG1289	transmembrane transporter activity
A1D75_RS24410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A1D75_RS24415	COG0512	Glutamine amidotransferase of anthranilate synthase
A1D75_RS24420	COG2184	nucleotidyltransferase activity
A1D75_RS24430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A1D75_RS24445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A1D75_RS24450	COG2146	nitrite reductase [NAD(P)H] activity
A1D75_RS24455	COG2116	formate transmembrane transporter activity
A1D75_RS24470	COG0531	amino acid
A1D75_RS24475	COG2222	sugar isomerase
A1D75_RS24480	COG1082	Xylose isomerase domain protein TIM barrel
A1D75_RS24485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1D75_RS24490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1D75_RS24495	COG2188	Transcriptional regulator
A1D75_RS24500	COG0180	Tryptophanyl-tRNA synthetase
A1D75_RS24505	COG0546	phosphoglycolate phosphatase activity
A1D75_RS24510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A1D75_RS24515	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A1D75_RS24520	COG3266	domain, Protein
A1D75_RS24535	COG4796	Type ii and iii secretion system protein
A1D75_RS24550	COG3166	PFAM Fimbrial assembly family protein
A1D75_RS24555	COG4972	Pilus assembly protein
A1D75_RS24560	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A1D75_RS24565	COG0494	nUDIX hydrolase
A1D75_RS24575	COG1011	Hydrolase
A1D75_RS24580	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A1D75_RS24590	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A1D75_RS24610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A1D75_RS24615	COG2183	response to ionizing radiation
A1D75_RS24620	COG1918	ferrous iron import across plasma membrane
A1D75_RS24625	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A1D75_RS24635	COG5464	transposase or invertase
A1D75_RS24645	COG1040	competence protein
A1D75_RS24655	COG2610	gluconate transmembrane transporter activity
A1D75_RS24660	COG1640	4-alpha-glucanotransferase
A1D75_RS24665	COG0058	SHG alpha-glucan phosphorylase activity
A1D75_RS24690	COG1690	Belongs to the RtcB family
A1D75_RS24695	COG4650	regulator
A1D75_RS24700	COG1349	DNA-binding transcription factor activity
A1D75_RS24715	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A1D75_RS24730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A1D75_RS24735	COG0058	SHG alpha-glucan phosphorylase activity
A1D75_RS24755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A1D75_RS24760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A1D75_RS24765	COG2095	MarC family integral membrane protein
A1D75_RS24785	COG0514	ATP-dependent DNA helicase (RecQ)
A1D75_RS24790	COG2610	gluconate transmembrane transporter activity
A1D75_RS24795	COG3265	gluconokinase activity
A1D75_RS24800	COG1609	Transcriptional regulator
A1D75_RS24805	COG1741	Belongs to the pirin family
A1D75_RS24810	COG0673	inositol 2-dehydrogenase activity
A1D75_RS24815	COG1247	-acetyltransferase
A1D75_RS24830	COG0405	Gamma-glutamyltransferase
A1D75_RS24840	COG0584	glycerophosphoryl diester phosphodiesterase
A1D75_RS24845	COG3842	ATPase activity
A1D75_RS24855	COG1175	transmembrane transport
A1D75_RS24860	COG1653	transport
A1D75_RS24870	COG0410	ABC transporter
A1D75_RS24875	COG0411	ABC transporter
A1D75_RS24880	COG4177	L-phenylalanine transmembrane transporter activity
A1D75_RS24885	COG0559	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS24890	COG0683	leucine binding
A1D75_RS24895	COG0456	acetyltransferase
A1D75_RS24910	COG0683	leucine binding
A1D75_RS24915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A1D75_RS24920	COG2177	Part of the ABC transporter FtsEX involved in
A1D75_RS24925	COG2884	Cell division ATP-binding protein ftsE
A1D75_RS24930	COG0552	protein localization to endoplasmic reticulum
A1D75_RS24935	COG0742	ribosomal rna small subunit methyltransferase
A1D75_RS24940	COG3776	membrane
A1D75_RS24950	COG3714	YhhN family
A1D75_RS24965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A1D75_RS24975	COG0477	Major facilitator Superfamily
A1D75_RS24980	COG0628	permease
A1D75_RS25000	COG0204	Acyl-transferase
A1D75_RS25010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1D75_RS25030	COG1216	Glycosyl transferase, family 2
A1D75_RS25055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1D75_RS25065	COG1028	Short-chain dehydrogenase reductase Sdr
A1D75_RS25070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1D75_RS25075	COG2091	lysine biosynthetic process via aminoadipic acid
A1D75_RS25080	COG0747	negative chemotaxis
A1D75_RS25085	COG0601	transmembrane transport
A1D75_RS25090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A1D75_RS25095	COG0444	Belongs to the ABC transporter superfamily
A1D75_RS25100	COG1124	(ABC) transporter
A1D75_RS25110	COG2188	Transcriptional regulator
A1D75_RS25120	COG3414	Phosphotransferase system galactitol-specific IIB component
A1D75_RS25125	COG3775	system Galactitol-specific IIC component
A1D75_RS25140	COG0191	fructose-bisphosphate aldolase activity
A1D75_RS25155	COG0842	Transport permease protein
A1D75_RS25160	COG0842	Transport permease protein
A1D75_RS25160	COG1129	ABC transporter
A1D75_RS25165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1D75_RS25185	COG2081	HI0933 family
A1D75_RS25190	COG0306	phosphate transporter
A1D75_RS25200	COG0589	response to stress
A1D75_RS25210	COG3104	oligopeptide transport
A1D75_RS25220	COG0339	signal peptide processing
A1D75_RS25225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A1D75_RS25230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1D75_RS25240	COG0640	Transcriptional regulator
A1D75_RS25245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A1D75_RS25250	COG1393	Belongs to the ArsC family
A1D75_RS25260	COG3065	identical protein binding
A1D75_RS25265	COG2197	response regulator
A1D75_RS25270	COG3720	iron ion transport
A1D75_RS25275	COG4771	TonB-dependent receptor
A1D75_RS25285	COG4558	Periplasmic binding protein
A1D75_RS25295	COG3721	Heme iron utilization protein
A1D75_RS25305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1D75_RS25310	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A1D75_RS25315	COG1285	pathogenesis
A1D75_RS25330	COG3247	response to pH
A1D75_RS25335	COG2771	luxR family
A1D75_RS25345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1D75_RS25350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1D75_RS25355	COG2207	Transcriptional regulator
A1D75_RS25360	COG2207	Transcriptional regulator
A1D75_RS25365	COG0076	glutamate decarboxylase activity
A1D75_RS25370	COG1858	cytochrome C peroxidase
A1D75_RS25380	COG2197	response regulator
A1D75_RS25385	COG0583	DNA-binding transcription factor activity
A1D75_RS25390	COG1295	ribonuclease BN
A1D75_RS25395	COG0477	Major facilitator Superfamily
A1D75_RS25400	COG2982	Protein involved in outer membrane biogenesis
A1D75_RS25405	COG2200	EAL domain
A1D75_RS25415	COG0612	Peptidase, M16
A1D75_RS25425	COG2199	diguanylate cyclase activity
A1D75_RS25425	COG2200	EAL domain
A1D75_RS25435	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A1D75_RS25440	COG1215	transferase activity, transferring glycosyl groups
A1D75_RS25445	COG1215	transferase activity, transferring glycosyl groups
A1D75_RS25470	COG2194	sulfuric ester hydrolase activity
A1D75_RS25480	COG0814	amino acid
A1D75_RS25485	COG4608	Belongs to the ABC transporter superfamily
A1D75_RS25490	COG0444	Belongs to the ABC transporter superfamily
A1D75_RS25495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A1D75_RS25500	COG0601	transmembrane transport
A1D75_RS25510	COG0747	negative chemotaxis
A1D75_RS25520	COG2194	sulfuric ester hydrolase activity
A1D75_RS25525	COG3539	Fimbrial protein
A1D75_RS25530	COG3539	Fimbrial protein
A1D75_RS25540	COG3121	Chaperone
A1D75_RS25545	COG3539	Fimbrial protein
A1D75_RS25550	COG2223	nitrite transmembrane transporter activity
A1D75_RS25555	COG5571	outer membrane autotransporter
A1D75_RS25560	COG2818	Glycosylase
A1D75_RS25565	COG0456	acetyltransferase
A1D75_RS25570	COG0243	molybdopterin cofactor binding
A1D75_RS25575	COG2885	chlorophyll binding
A1D75_RS25590	COG2944	sequence-specific DNA binding
A1D75_RS25595	COG1278	Cold shock
A1D75_RS25620	COG3274	enterobacterial common antigen metabolic process
A1D75_RS25625	COG4682	membrane
A1D75_RS25630	COG4682	membrane
A1D75_RS25635	COG1070	Carbohydrate kinase
A1D75_RS25645	COG4213	ABC transporter substrate-binding protein
A1D75_RS25655	COG4214	carbohydrate transport
A1D75_RS25660	COG2207	Transcriptional regulator
A1D75_RS25660	COG1609	Transcriptional regulator
A1D75_RS25665	COG2992	FlgJ-related protein
A1D75_RS25670	COG0366	Alpha amylase catalytic
A1D75_RS25675	COG3977	Valine--pyruvate aminotransferase
A1D75_RS25680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1D75_RS25685	COG1414	Transcriptional regulator
A1D75_RS25695	COG2211	Major facilitator Superfamily
A1D75_RS25705	COG3713	MltA-interacting MipA family protein
A1D75_RS25710	COG0583	DNA-binding transcription factor activity
A1D75_RS25715	COG1566	PFAM secretion protein HlyD family protein
A1D75_RS25730	COG1012	belongs to the aldehyde dehydrogenase family
A1D75_RS25740	COG1454	alcohol dehydrogenase
A1D75_RS25745	COG3276	selenocysteine insertion sequence binding
A1D75_RS25755	COG0625	glutathione transferase activity
A1D75_RS25760	COG3209	COG3209 Rhs family protein
A1D75_RS25765	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A1D75_RS25785	COG1566	PFAM secretion protein HlyD family protein
A1D75_RS25795	COG2213	PTS system mannitol-specific
A1D75_RS25795	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS25805	COG3722	fumarate hydratase activity
A1D75_RS25830	COG5295	Hep Hag repeat protein
A1D75_RS25835	COG1620	l-lactate permease
A1D75_RS25840	COG2186	Transcriptional regulator
A1D75_RS25850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A1D75_RS25855	COG1045	serine acetyltransferase
A1D75_RS25870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A1D75_RS25875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A1D75_RS25890	COG4942	peptidase
A1D75_RS25895	COG2861	carbohydrate metabolic process
A1D75_RS25900	COG1216	Glycosyl transferase, family 2
A1D75_RS25910	COG0156	8-amino-7-oxononanoate synthase activity
A1D75_RS25925	COG0859	PFAM glycosyl transferase family 9
A1D75_RS25930	COG0859	PFAM glycosyl transferase family 9
A1D75_RS25950	COG3642	lipopolysaccharide core region biosynthetic process
A1D75_RS25960	COG0515	serine threonine protein kinase
A1D75_RS25965	COG0438	transferase activity, transferring glycosyl groups
A1D75_RS25970	COG0859	PFAM glycosyl transferase family 9
A1D75_RS25975	COG1519	Transferase
A1D75_RS26005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A1D75_RS26030	COG1561	YicC-like family, N-terminal region
A1D75_RS26035	COG3645	SOS response
A1D75_RS26040	COG2860	membrane
A1D75_RS26050	COG0194	GDP metabolic process
A1D75_RS26060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A1D75_RS26065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1D75_RS26070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A1D75_RS26080	COG0786	glutamate:sodium symporter activity
A1D75_RS26085	COG2233	PERMEase
A1D75_RS26090	COG2982	Protein involved in outer membrane biogenesis
A1D75_RS26095	COG1501	Belongs to the glycosyl hydrolase 31 family
A1D75_RS26100	COG2211	Major facilitator Superfamily
A1D75_RS26110	COG0582	viral genome integration into host DNA
A1D75_RS26150	COG3436	PFAM IS66 Orf2 family protein
A1D75_RS26155	COG4372	Transposase
A1D75_RS26215	COG5492	domain, Protein
A1D75_RS26385	COG0697	spore germination
A1D75_RS26390	COG1464	Belongs to the NlpA lipoprotein family
A1D75_RS26400	COG2814	Major facilitator Superfamily
A1D75_RS26435	COG2271	Major facilitator Superfamily
A1D75_RS26440	COG2271	Major facilitator Superfamily
A1D75_RS26445	COG3851	Histidine kinase
A1D75_RS26450	COG2197	response regulator
A1D75_RS26470	COG0440	acetolactate synthase activity
A1D75_RS26475	COG0028	Belongs to the TPP enzyme family
A1D75_RS26490	COG2814	Major facilitator Superfamily
A1D75_RS26495	COG0641	radical SAM
A1D75_RS26505	COG2149	membrane
A1D75_RS26515	COG3119	arylsulfatase activity
A1D75_RS26520	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A1D75_RS26525	COG2207	Transcriptional regulator
A1D75_RS26540	COG2188	Transcriptional regulator
A1D75_RS26560	COG5645	(Lipo)protein
A1D75_RS26565	COG0823	Involved in the tonB-independent uptake of proteins
A1D75_RS26570	COG0644	oxidoreductase
A1D75_RS26580	COG0561	phosphatase activity
A1D75_RS26585	COG3753	Protein conserved in bacteria
A1D75_RS26590	COG0187	DNA topoisomerase II activity
A1D75_RS26600	COG0592	DNA-directed DNA polymerase activity
A1D75_RS26660	COG0814	amino acid
A1D75_RS26675	COG2091	lysine biosynthetic process via aminoadipic acid
A1D75_RS26680	COG0431	NADPH-dependent FMN reductase
A1D75_RS26685	COG2252	PERMEase
A1D75_RS26690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A1D75_RS26730	COG0704	Plays a role in the regulation of phosphate uptake
A1D75_RS26735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A1D75_RS26740	COG0581	inorganic phosphate transmembrane transporter activity
A1D75_RS26745	COG0573	inorganic phosphate transmembrane transporter activity
A1D75_RS26750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A1D75_RS26760	COG3539	Fimbrial protein
A1D75_RS26785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A1D75_RS26795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A1D75_RS26835	COG3312	ion transport
A1D75_RS26850	COG0716	FMN binding
A1D75_RS26855	COG1522	sequence-specific DNA binding
A1D75_RS26875	COG3158	transport of potassium into the cell
A1D75_RS26885	COG1129	ABC transporter
A1D75_RS26890	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1D75_RS26895	COG1879	ABC-type sugar transport system periplasmic component
A1D75_RS26900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1D75_RS26905	COG1609	Transcriptional regulator
A1D75_RS26910	COG0477	Major facilitator Superfamily
A1D75_RS26915	COG2186	Transcriptional regulator
A1D75_RS26955	COG3085	chromosome segregation
A1D75_RS26960	COG0606	chelatase, subunit chli
A1D75_RS26980	COG3978	acetolactate synthase activity
A1D75_RS26985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A1D75_RS26995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A1D75_RS27000	COG0583	DNA-binding transcription factor activity
A1D75_RS27010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A1D75_RS27015	COG3692	DNA binding
A1D75_RS27020	COG0210	DNA helicase
A1D75_RS27035	COG3118	belongs to the thioredoxin family
A1D75_RS27045	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A1D75_RS27050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A1D75_RS27055	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
A1D75_RS27060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A1D75_RS27065	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A1D75_RS27070	COG1088	dTDP-glucose 4,6-dehydratase activity
A1D75_RS27075	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A1D75_RS27080	COG0456	acetyltransferase
A1D75_RS27085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A1D75_RS27090	COG2244	polysaccharide biosynthetic process
A1D75_RS27095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A1D75_RS27110	COG1113	amino acid transport
A1D75_RS27145	COG0641	radical SAM
A1D75_RS27150	COG3119	arylsulfatase activity
A1D75_RS27155	COG3071	HemY protein
A1D75_RS27160	COG2959	enzyme of heme biosynthesis
A1D75_RS27165	COG1587	Uroporphyrinogen-III synthase
A1D75_RS27175	COG3072	Adenylate cyclase
A1D75_RS27190	COG5567	small periplasmic lipoprotein
A1D75_RS27200	COG3159	Protein conserved in bacteria
A1D75_RS27210	COG1011	Hydrolase
A1D75_RS27215	COG0210	DNA helicase
A1D75_RS27220	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
A1D75_RS27225	COG3698	Phosphodiester glycosidase
A1D75_RS27230	COG0598	Magnesium transport protein CorA
A1D75_RS27260	COG2962	Rard protein
A1D75_RS27265	COG2050	protein possibly involved in aromatic compounds catabolism
A1D75_RS27270	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A1D75_RS27275	COG0514	ATP-dependent DNA helicase (RecQ)
A1D75_RS27280	COG1280	lysine exporter protein (LysE YggA)
A1D75_RS27285	COG1280	lysine exporter protein (LysE YggA)
A1D75_RS27290	COG2267	carboxylic ester hydrolase activity
A1D75_RS27295	COG0561	phosphatase activity
A1D75_RS27300	COG0697	spore germination
A1D75_RS27305	COG0583	DNA-binding transcription factor activity
A1D75_RS27310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A1D75_RS27315	COG0412	Dienelactone hydrolase
A1D75_RS27320	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A1D75_RS27325	COG1322	Protein conserved in bacteria
A1D75_RS27335	COG3165	ubiquinone biosynthetic process from chorismate
A1D75_RS27345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A1D75_RS27350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A1D75_RS27355	COG0805	protein transport
A1D75_RS27360	COG0084	hydrolase, TatD family'
A1D75_RS27365	COG0250	Participates in transcription elongation, termination and antitermination
A1D75_RS27370	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A1D75_RS27375	COG0543	2 iron, 2 sulfur cluster binding
A1D75_RS27380	COG0183	Belongs to the thiolase family
A1D75_RS27395	COG1739	Uncharacterized protein family UPF0029
A1D75_RS27400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A1D75_RS27405	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
A1D75_RS27435	COG1763	Mo-molybdopterin cofactor biosynthetic process
A1D75_RS27440	COG0746	molybdenum cofactor guanylyltransferase activity
A1D75_RS27445	COG3084	Protein conserved in bacteria
A1D75_RS27450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A1D75_RS27455	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A1D75_RS27460	COG5339	Protein conserved in bacteria
A1D75_RS27465	COG0204	Acyl-transferase
A1D75_RS27475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A1D75_RS27475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A1D75_RS27485	COG3078	GTPase activator activity
A1D75_RS27490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A1D75_RS27500	COG2204	response regulator
A1D75_RS27505	COG3852	Histidine kinase
A1D75_RS27510	COG0174	glutamine synthetase
A1D75_RS27515	COG1217	gtp-binding protein TYPA
A1D75_RS27520	COG2188	Transcriptional regulator
A1D75_RS27525	COG1082	Xylose isomerase domain protein TIM barrel
A1D75_RS27530	COG2271	Major facilitator Superfamily
A1D75_RS27535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A1D75_RS27540	COG2211	Major facilitator Superfamily
A1D75_RS27545	COG2211	Major facilitator Superfamily
A1D75_RS27550	COG1501	Belongs to the glycosyl hydrolase 31 family
A1D75_RS27560	COG2017	converts alpha-aldose to the beta-anomer
A1D75_RS27565	COG2942	2-epimerase
A1D75_RS27570	COG3684	Belongs to the aldolase LacD family
A1D75_RS27575	COG2084	Dehydrogenase
A1D75_RS27580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1D75_RS27585	COG1349	DNA-binding transcription factor activity
A1D75_RS27590	COG1011	Hydrolase
A1D75_RS27605	COG0456	acetyltransferase
A1D75_RS27630	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A1D75_RS27635	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A1D75_RS27645	COG2864	formate dehydrogenase
A1D75_RS27650	COG0437	4 iron, 4 sulfur cluster binding
A1D75_RS27670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS27670	COG3711	transcriptional antiterminator
A1D75_RS27675	COG1363	Peptidase, m42
A1D75_RS27680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1D75_RS27680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1D75_RS27685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS27720	COG1917	Cupin 2, conserved barrel domain protein
A1D75_RS27720	COG4977	sequence-specific DNA binding
A1D75_RS27730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A1D75_RS27740	COG2258	MOSC domain
A1D75_RS27745	COG2205	protein histidine kinase activity
A1D75_RS27750	COG0745	RESPONSE REGULATOR receiver
A1D75_RS27755	COG3678	ATP-independent chaperone mediated protein folding
A1D75_RS27770	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A1D75_RS27790	COG3152	Membrane
A1D75_RS27795	COG3691	Protein conserved in bacteria
A1D75_RS27800	COG0589	response to stress
A1D75_RS27810	COG1494	fructose-1,6-bisphosphatase
A1D75_RS27820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A1D75_RS27845	COG1575	Belongs to the MenA family. Type 1 subfamily
A1D75_RS27860	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A1D75_RS27865	COG1609	Transcriptional regulator
A1D75_RS27870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A1D75_RS27880	COG3209	COG3209 Rhs family protein
A1D75_RS27895	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
A1D75_RS27905	COG0626	cystathionine gamma-synthase activity
A1D75_RS27910	COG0527	aspartate kinase activity
A1D75_RS27910	COG0460	homoserine dehydrogenase
A1D75_RS27915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A1D75_RS27925	COG0697	spore germination
A1D75_RS27930	COG3738	Protein conserved in bacteria
A1D75_RS27935	COG0371	Dehydrogenase
A1D75_RS27940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A1D75_RS27945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS27945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1D75_RS27945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A1D75_RS27950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1D75_RS27955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1D75_RS27965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A1D75_RS27970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1D75_RS27975	COG2207	Transcriptional regulator
A1D75_RS27980	COG2194	sulfuric ester hydrolase activity
A1D75_RS27995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A1D75_RS28005	COG0165	Argininosuccinate lyase
A1D75_RS28010	COG0583	DNA-binding transcription factor activity
A1D75_RS28015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1D75_RS28020	COG1473	amidohydrolase
A1D75_RS28025	COG0477	Major facilitator Superfamily
A1D75_RS28030	COG1309	transcriptional regulator
A1D75_RS28040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A1D75_RS28045	COG4206	TonB-dependent receptor
A1D75_RS28050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A1D75_RS28075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A1D75_RS28080	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A1D75_RS28080	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A1D75_RS28115	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A1D75_RS28120	COG0250	Participates in transcription elongation, termination and antitermination
A1D75_RS28160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A1D75_RS28165	COG2022	thiamine diphosphate biosynthetic process
A1D75_RS28170	COG2104	thiamine diphosphate biosynthetic process
A1D75_RS28175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A1D75_RS28210	COG3068	Protein conserved in bacteria
A1D75_RS28225	COG3678	ATP-independent chaperone mediated protein folding
A1D75_RS28230	COG4191	Histidine kinase
A1D75_RS28235	COG2204	response regulator
A1D75_RS28240	COG0151	Belongs to the GarS family
A1D75_RS28270	COG0456	acetyltransferase
A1D75_RS28280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A1D75_RS28285	COG2224	Isocitrate lyase
A1D75_RS28300	COG1414	Transcriptional regulator
A1D75_RS28305	COG1410	methionine synthase
A1D75_RS28305	COG0646	methionine synthase
A1D75_RS28310	COG1283	sodium-dependent phosphate transmembrane transporter activity
A1D75_RS28355	COG1187	pseudouridine synthase activity
A1D75_RS28365	COG0527	aspartate kinase activity
A1D75_RS28395	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A1D75_RS28410	COG2814	Major facilitator Superfamily
A1D75_RS28410	COG0477	Major facilitator Superfamily
A1D75_RS28415	COG3833	ABC-type maltose transport systems, permease component
A1D75_RS28420	COG1175	transmembrane transport
A1D75_RS28425	COG2182	Extracellular solute-binding protein
A1D75_RS28430	COG3842	ATPase activity
A1D75_RS28495	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A1D75_RS28505	COG1525	nuclease
A1D75_RS28605	COG3468	outer membrane autotransporter barrel domain protein
A1D75_RS28620	COG0726	polysaccharide deacetylase
A1D75_RS28625	COG0297	glycogen (starch) synthase activity
A1D75_RS28630	COG2194	sulfuric ester hydrolase activity
A1D75_RS28635	COG1560	Kdo2-lipid A biosynthetic process
A1D75_RS28675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A1D75_RS28755	COG2274	protein secretion by the type I secretion system
A1D75_RS28970	COG1475	DNA binding