locus-tag	class	description
C6993_RS00040	COG3201	nicotinamide mononucleotide transporter
C6993_RS00045	COG1230	cation diffusion facilitator family transporter
C6993_RS00060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C6993_RS00070	COG2017	converts alpha-aldose to the beta-anomer
C6993_RS00080	COG1085	galactose-1-phosphate uridylyltransferase
C6993_RS00085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6993_RS00090	COG1119	ATPase activity
C6993_RS00095	COG2005	Transcriptional regulator
C6993_RS00095	COG3585	molybdate ion transport
C6993_RS00110	COG0725	ABC transporter, periplasmic molybdate-binding protein
C6993_RS00115	COG4149	molybdate abc transporter
C6993_RS00125	COG0561	phosphatase activity
C6993_RS00135	COG0583	DNA-binding transcription factor activity
C6993_RS00140	COG2828	Protein conserved in bacteria
C6993_RS00145	COG0471	metal ion transport
C6993_RS00150	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C6993_RS00155	COG4677	pectinesterase activity
C6993_RS00160	COG0582	viral genome integration into host DNA
C6993_RS00400	COG3772	lysozyme
C6993_RS00425	COG4220	transposase activity
C6993_RS00455	COG3436	PFAM IS66 Orf2 family protein
C6993_RS00460	COG4372	Transposase
C6993_RS00525	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS00555	COG4372	Transposase
C6993_RS00560	COG3436	PFAM IS66 Orf2 family protein
C6993_RS00595	COG1881	PFAM PEBP family protein
C6993_RS00600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6993_RS00615	COG2226	methyltransferase
C6993_RS00620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C6993_RS00630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C6993_RS00640	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6993_RS00650	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C6993_RS00655	COG0314	molybdopterin synthase activity
C6993_RS00660	COG0670	Belongs to the BI1 family
C6993_RS00665	COG0670	Belongs to the BI1 family
C6993_RS00670	COG0392	lysyltransferase activity
C6993_RS00675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6993_RS00680	COG3568	Endonuclease Exonuclease Phosphatase
C6993_RS00690	COG0842	Transport permease protein
C6993_RS00695	COG0842	Transport permease protein
C6993_RS00700	COG1131	(ABC) transporter
C6993_RS00710	COG1309	transcriptional regulator
C6993_RS00715	COG0513	Belongs to the DEAD box helicase family
C6993_RS00720	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C6993_RS00725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6993_RS00730	COG1199	ATP-dependent helicase activity
C6993_RS00740	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
C6993_RS00745	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS00760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C6993_RS00770	COG4774	siderophore transport
C6993_RS00785	COG0668	transmembrane transport
C6993_RS00790	COG1126	abc transporter atp-binding protein
C6993_RS00795	COG0765	amino acid transport
C6993_RS00800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6993_RS00820	COG5006	permease, DMT superfamily
C6993_RS00825	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C6993_RS00830	COG2194	sulfuric ester hydrolase activity
C6993_RS00840	COG1321	iron dependent repressor
C6993_RS00845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C6993_RS00850	COG1376	ErfK ybiS ycfS ynhG family protein
C6993_RS00855	COG0488	(ABC) transporter
C6993_RS00865	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS00875	COG0561	phosphatase activity
C6993_RS00880	COG1882	Formate acetyltransferase
C6993_RS00885	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C6993_RS00890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6993_RS00895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C6993_RS00900	COG0303	'Molybdopterin
C6993_RS00905	COG1446	asparaginase
C6993_RS00930	COG2200	EAL domain
C6993_RS00935	COG2199	diguanylate cyclase activity
C6993_RS00950	COG2133	pyrroloquinoline quinone binding
C6993_RS00955	COG0625	glutathione transferase activity
C6993_RS00960	COG1686	Belongs to the peptidase S11 family
C6993_RS00965	COG1349	DNA-binding transcription factor activity
C6993_RS00970	COG0671	phosphoesterase, PA-phosphatase related
C6993_RS00975	COG2814	Major facilitator Superfamily
C6993_RS00985	COG0561	phosphatase activity
C6993_RS00990	COG0738	Major facilitator superfamily
C6993_RS00995	COG3226	Transcriptional regulator
C6993_RS01010	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C6993_RS01020	COG0778	Nitroreductase
C6993_RS01040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C6993_RS01045	COG3842	ATPase activity
C6993_RS01050	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6993_RS01055	COG1177	transmembrane transport
C6993_RS01070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6993_RS01075	COG4160	amino acid transport
C6993_RS01080	COG4215	(ABC) transporter
C6993_RS01085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6993_RS01090	COG1126	abc transporter atp-binding protein
C6993_RS01105	COG3023	N-Acetylmuramoyl-L-alanine amidase
C6993_RS01110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6993_RS01115	COG0702	epimerase
C6993_RS01120	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C6993_RS01125	COG0028	Belongs to the TPP enzyme family
C6993_RS01130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6993_RS01140	COG2431	L-lysine efflux transmembrane transporter activity
C6993_RS01155	COG3593	DNA synthesis involved in DNA repair
C6993_RS01160	COG2990	Protein conserved in bacteria
C6993_RS01165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6993_RS01170	COG1136	(ABC) transporter
C6993_RS01170	COG0577	efflux transmembrane transporter activity
C6993_RS01175	COG1278	Cold shock
C6993_RS01185	COG0542	response to heat
C6993_RS01205	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C6993_RS01210	COG4988	ABC transporter
C6993_RS01215	COG0492	ferredoxin-NADP+ reductase activity
C6993_RS01225	COG1522	sequence-specific DNA binding
C6993_RS01240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C6993_RS01250	COG0243	molybdopterin cofactor binding
C6993_RS01255	COG0437	4 iron, 4 sulfur cluster binding
C6993_RS01260	COG3302	dmso reductase anchor subunit
C6993_RS01265	COG1335	isochorismatase
C6993_RS01275	COG0531	amino acid
C6993_RS01280	COG0583	DNA-binding transcription factor activity
C6993_RS01285	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6993_RS01290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C6993_RS01295	COG1882	Formate acetyltransferase
C6993_RS01300	COG2116	formate transmembrane transporter activity
C6993_RS01305	COG1944	ATP diphosphatase activity
C6993_RS01310	COG2323	membrane
C6993_RS01325	COG0501	Belongs to the peptidase M48B family
C6993_RS01335	COG0539	negative regulation of cytoplasmic translation
C6993_RS01345	COG2333	competence protein COMEC
C6993_RS01345	COG0658	competence protein
C6993_RS01350	COG1132	(ABC) transporter
C6993_RS01360	COG3214	Protein conserved in bacteria
C6993_RS01375	COG3173	Aminoglycoside phosphotransferase
C6993_RS01380	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C6993_RS01385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6993_RS01395	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
C6993_RS01405	COG2989	Protein conserved in bacteria
C6993_RS01415	COG3108	Peptidase M15
C6993_RS01420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6993_RS01425	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS01435	COG1448	Aminotransferase
C6993_RS01455	COG0308	aminopeptidase N
C6993_RS01465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6993_RS01475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6993_RS01480	COG0431	NADPH-dependent FMN reductase
C6993_RS01490	COG3539	Fimbrial protein
C6993_RS01495	COG3121	Chaperone
C6993_RS01500	COG3188	usher protein
C6993_RS01505	COG3539	Fimbrial protein
C6993_RS01510	COG3539	Fimbrial protein
C6993_RS01515	COG3539	Fimbrial protein
C6993_RS01520	COG3121	Chaperone
C6993_RS01535	COG0633	Ferredoxin
C6993_RS01535	COG3217	Mosc domain protein beta barrel domain protein
C6993_RS01545	COG0488	(ABC) transporter
C6993_RS01550	COG2995	paraquat-inducible protein a
C6993_RS01555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C6993_RS01555	COG3008	intermembrane lipid transfer
C6993_RS01560	COG3009	Protein conserved in bacteria
C6993_RS01565	COG3130	regulation of translation
C6993_RS01575	COG1067	ATP-dependent peptidase activity
C6993_RS01585	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C6993_RS01585	COG2885	chlorophyll binding
C6993_RS01600	COG3070	regulator of competence-specific genes
C6993_RS01605	COG1289	transmembrane transporter activity
C6993_RS01610	COG3304	Inner membrane component domain
C6993_RS01615	COG0210	DNA helicase
C6993_RS01630	COG1832	CoA-binding protein
C6993_RS01645	COG1254	Belongs to the acylphosphatase family
C6993_RS01650	COG2920	part of a sulfur-relay system
C6993_RS01655	COG0670	Belongs to the BI1 family
C6993_RS01670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6993_RS01725	COG1484	DNA-dependent DNA replication
C6993_RS01730	COG1846	Transcriptional regulator
C6993_RS01780	COG1403	HNH endonuclease
C6993_RS01785	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C6993_RS01805	COG2207	Transcriptional regulator
C6993_RS01860	COG3772	lysozyme
C6993_RS01890	COG4220	transposase activity
C6993_RS01910	COG1030	water channel activity
C6993_RS02000	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS02030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6993_RS02100	COG1846	Transcriptional regulator
C6993_RS02170	COG1403	HNH endonuclease
C6993_RS02175	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C6993_RS02190	COG2207	Transcriptional regulator
C6993_RS02255	COG3772	lysozyme
C6993_RS02385	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS02420	COG1879	ABC-type sugar transport system periplasmic component
C6993_RS02425	COG0745	RESPONSE REGULATOR receiver
C6993_RS02430	COG3005	denitrification pathway
C6993_RS02435	COG0243	molybdopterin cofactor binding
C6993_RS02480	COG3729	General stress protein
C6993_RS02485	COG2233	PERMEase
C6993_RS02520	COG1309	transcriptional regulator
C6993_RS02525	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C6993_RS02525	COG0506	proline dehydrogenase activity
C6993_RS02525	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C6993_RS02540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6993_RS02560	COG2822	iron ion transport
C6993_RS02570	COG1702	phosphate starvation-inducible protein PhoH
C6993_RS02590	COG0582	viral genome integration into host DNA
C6993_RS02620	COG4983	Phage plasmid primase, P4 family domain protein
C6993_RS02645	COG4372	Transposase
C6993_RS02650	COG3436	PFAM IS66 Orf2 family protein
C6993_RS02695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C6993_RS02700	COG2194	sulfuric ester hydrolase activity
C6993_RS02715	COG0829	nickel cation binding
C6993_RS02760	COG0254	rRNA binding
C6993_RS02805	COG3436	PFAM IS66 Orf2 family protein
C6993_RS02810	COG4372	Transposase
C6993_RS02850	COG1358	cellular component organization or biogenesis
C6993_RS02915	COG4771	TonB-dependent receptor
C6993_RS03000	COG3468	outer membrane autotransporter barrel domain protein
C6993_RS03040	COG2003	Belongs to the UPF0758 family
C6993_RS03090	COG3381	protein complex oligomerization
C6993_RS03100	COG1462	curli production assembly transport component CsgG
C6993_RS03115	COG2197	response regulator
C6993_RS03150	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C6993_RS03155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6993_RS03180	COG2943	transferase activity, transferring hexosyl groups
C6993_RS03185	COG5645	(Lipo)protein
C6993_RS03200	COG1560	Kdo2-lipid A biosynthetic process
C6993_RS03210	COG2353	YceI-like domain
C6993_RS03215	COG3038	cytochrome b561
C6993_RS03255	COG2999	glutathione oxidoreductase activity
C6993_RS03265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6993_RS03275	COG0673	inositol 2-dehydrogenase activity
C6993_RS03280	COG0728	peptidoglycan biosynthetic process
C6993_RS03285	COG3418	PFAM FlgN family protein
C6993_RS03290	COG2747	anti-sigma28 factor FlgM
C6993_RS03295	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C6993_RS03300	COG1815	bacterial-type flagellum-dependent cell motility
C6993_RS03305	COG1558	bacterial-type flagellum-dependent cell motility
C6993_RS03310	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C6993_RS03315	COG1749	Flagellar hook protein flgE
C6993_RS03320	COG4787	bacterial-type flagellum-dependent cell motility
C6993_RS03325	COG4786	Flagellar basal body rod
C6993_RS03340	COG1705	Flagellar rod assembly protein muramidase FlgJ
C6993_RS03340	COG3951	Flagellar rod assembly protein muramidase FlgJ
C6993_RS03345	COG1256	bacterial-type flagellum assembly
C6993_RS03350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6993_RS03355	COG1530	ribonuclease E activity
C6993_RS03365	COG0564	pseudouridine synthase activity
C6993_RS03370	COG0424	maF-like protein
C6993_RS03375	COG1399	metal-binding, possibly nucleic acid-binding protein
C6993_RS03395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C6993_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS03415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6993_RS03420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C6993_RS03430	COG0470	DNA polymerase III
C6993_RS03435	COG0084	hydrolase, TatD family'
C6993_RS03440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS03440	COG1263	PTS System
C6993_RS03445	COG4773	Receptor
C6993_RS03450	COG0537	adenosine 5'-monophosphoramidase activity
C6993_RS03455	COG5633	Lipoprotein
C6993_RS03460	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C6993_RS03480	COG1252	NADH dehydrogenase
C6993_RS03490	COG3134	Outer membrane lipoprotein
C6993_RS03495	COG1309	transcriptional regulator
C6993_RS03505	COG1376	ErfK ybiS ycfS ynhG family protein
C6993_RS03505	COG1388	LysM domain
C6993_RS03510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C6993_RS03515	COG4763	Acyl-transferase
C6993_RS03520	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6993_RS03525	COG1136	(ABC) transporter
C6993_RS03530	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6993_RS03540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C6993_RS03545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C6993_RS03555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C6993_RS03560	COG1177	transmembrane transport
C6993_RS03585	COG2850	peptidyl-arginine hydroxylation
C6993_RS03670	COG4220	transposase activity
C6993_RS03685	COG2205	protein histidine kinase activity
C6993_RS03695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C6993_RS03715	COG1187	pseudouridine synthase activity
C6993_RS03720	COG0538	isocitrate dehydrogenase activity
C6993_RS03730	COG5562	phage envelope protein
C6993_RS03735	COG0789	Transcriptional regulator
C6993_RS03740	COG2200	EAL domain
C6993_RS03765	COG2200	EAL domain
C6993_RS03825	COG2894	cell division
C6993_RS03860	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6993_RS03875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C6993_RS03880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6993_RS03900	COG2719	SpoVR family
C6993_RS03910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6993_RS03925	COG1619	proteins homologs of microcin C7 resistance protein MccF
C6993_RS03940	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C6993_RS03965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS03965	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
C6993_RS03965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6993_RS03970	COG1461	Dihydroxyacetone kinase
C6993_RS03975	COG2376	Dihydroxyacetone kinase
C6993_RS03980	COG3284	Transcriptional regulator
C6993_RS03985	COG3468	outer membrane autotransporter barrel domain protein
C6993_RS04000	COG0012	GTP binding
C6993_RS04015	COG0659	secondary active sulfate transmembrane transporter activity
C6993_RS04025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C6993_RS04055	COG2890	protein-(glutamine-N5) methyltransferase activity
C6993_RS04060	COG3094	Invasion gene expression up-regulator, SirB
C6993_RS04065	COG2912	Transglutaminase-like superfamily
C6993_RS04095	COG0387	Pfam Sodium calcium exchanger
C6993_RS04100	COG4572	Cation transport regulator
C6993_RS04105	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C6993_RS04110	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
C6993_RS04115	COG4932	domain protein
C6993_RS04120	COG2197	response regulator
C6993_RS04125	COG3850	Histidine kinase
C6993_RS04135	COG2223	nitrite transmembrane transporter activity
C6993_RS04140	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C6993_RS04145	COG1140	nitrate reductase beta subunit
C6993_RS04150	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C6993_RS04155	COG2181	nitrate reductase activity
C6993_RS04175	COG0788	formyltetrahydrofolate deformylase activity
C6993_RS04185	COG1752	Esterase of the alpha-beta hydrolase superfamily
C6993_RS04190	COG0745	RESPONSE REGULATOR receiver
C6993_RS04195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C6993_RS04205	COG1435	thymidine kinase activity
C6993_RS04215	COG1012	belongs to the aldehyde dehydrogenase family
C6993_RS04215	COG1454	alcohol dehydrogenase
C6993_RS04220	COG2095	MarC family integral membrane protein
C6993_RS04230	COG4166	transmembrane transport
C6993_RS04235	COG0601	transmembrane transport
C6993_RS04240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6993_RS04245	COG0444	Belongs to the ABC transporter superfamily
C6993_RS04250	COG4608	Belongs to the ABC transporter superfamily
C6993_RS04270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6993_RS04275	COG2350	Protein conserved in bacteria
C6993_RS04285	COG1607	acyl-coa hydrolase
C6993_RS04305	COG3047	cAMP biosynthetic process
C6993_RS04310	COG0582	viral genome integration into host DNA
C6993_RS04320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6993_RS04360	COG1396	sequence-specific DNA binding
C6993_RS04415	COG1403	HNH endonuclease
C6993_RS04420	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C6993_RS04475	COG3772	lysozyme
C6993_RS04620	COG2032	superoxide dismutase activity
C6993_RS04635	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS04660	COG0589	response to stress
C6993_RS04665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C6993_RS04675	COG0674	pyruvate-flavodoxin oxidoreductase activity
C6993_RS04675	COG1013	pyruvate-flavodoxin oxidoreductase activity
C6993_RS04675	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6993_RS04675	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
C6993_RS04680	COG3042	response to heat
C6993_RS04685	COG3187	Heat shock protein
C6993_RS04690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6993_RS04695	COG2911	Protein conserved in bacteria
C6993_RS04705	COG3784	Protein of unknown function (DUF1318)
C6993_RS04710	COG2207	Transcriptional regulator
C6993_RS04715	COG1012	belongs to the aldehyde dehydrogenase family
C6993_RS04720	COG3733	amine oxidase
C6993_RS04725	COG2030	dehydratase
C6993_RS04725	COG1012	belongs to the aldehyde dehydrogenase family
C6993_RS04730	COG3396	Phenylacetate-CoA oxygenase
C6993_RS04735	COG3460	Phenylacetate-CoA oxygenase
C6993_RS04740	COG3396	Phenylacetate-CoA oxygenase
C6993_RS04745	COG2151	metal-sulfur cluster biosynthetic enzyme
C6993_RS04750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6993_RS04755	COG1024	Enoyl-CoA hydratase
C6993_RS04760	COG1024	Enoyl-CoA hydratase
C6993_RS04765	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6993_RS04770	COG2050	protein possibly involved in aromatic compounds catabolism
C6993_RS04775	COG0183	Belongs to the thiolase family
C6993_RS04780	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
C6993_RS04785	COG3327	negative regulation of DNA-templated transcription, initiation
C6993_RS04790	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C6993_RS04795	COG0667	Aldo Keto reductase
C6993_RS04805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6993_RS04810	COG4589	Belongs to the CDS family
C6993_RS04815	COG2267	carboxylic ester hydrolase activity
C6993_RS04820	COG2453	phosphatase
C6993_RS04820	COG0671	phosphoesterase, PA-phosphatase related
C6993_RS04830	COG1643	Atp-dependent helicase
C6993_RS04835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C6993_RS04840	COG1012	belongs to the aldehyde dehydrogenase family
C6993_RS04845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6993_RS04850	COG3038	cytochrome b561
C6993_RS04865	COG0840	transmembrane signaling receptor activity
C6993_RS04870	COG0583	DNA-binding transcription factor activity
C6993_RS04875	COG5383	Protein conserved in bacteria
C6993_RS04895	COG2841	Protein conserved in bacteria
C6993_RS04900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6993_RS04905	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C6993_RS04910	COG1275	C4-dicarboxylate transporter malic acid transport protein
C6993_RS04915	COG0500	methyltransferase
C6993_RS04930	COG0675	Transposase, IS605 OrfB family
C6993_RS04935	COG3135	benzoate transporter
C6993_RS04940	COG1396	sequence-specific DNA binding
C6993_RS04945	COG0826	peptidase U32
C6993_RS04955	COG1724	mRNA binding
C6993_RS04960	COG1598	PFAM Uncharacterised protein family UPF0150
C6993_RS04970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C6993_RS04975	COG3842	ATPase activity
C6993_RS04980	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6993_RS04985	COG1177	transmembrane transport
C6993_RS05020	COG3238	Protein conserved in bacteria
C6993_RS05025	COG1247	-acetyltransferase
C6993_RS05035	COG2130	NADP-dependent
C6993_RS05040	COG1802	Transcriptional regulator
C6993_RS05045	COG4772	TonB-dependent receptor
C6993_RS05060	COG3391	amine dehydrogenase activity
C6993_RS05065	COG1113	amino acid transport
C6993_RS05070	COG0625	glutathione transferase activity
C6993_RS05115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6993_RS05120	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C6993_RS05125	COG0384	phenazine biosynthesis protein PhzF
C6993_RS05130	COG2181	nitrate reductase activity
C6993_RS05135	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C6993_RS05140	COG1140	nitrate reductase beta subunit
C6993_RS05145	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C6993_RS05150	COG2223	nitrite transmembrane transporter activity
C6993_RS05155	COG4886	Leucine-rich repeat (LRR) protein
C6993_RS05160	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C6993_RS05165	COG0697	spore germination
C6993_RS05170	COG0243	molybdopterin cofactor binding
C6993_RS05170	COG3383	formate dehydrogenase (NAD+) activity
C6993_RS05175	COG0243	molybdopterin cofactor binding
C6993_RS05175	COG3383	formate dehydrogenase (NAD+) activity
C6993_RS05180	COG0437	4 iron, 4 sulfur cluster binding
C6993_RS05185	COG2864	formate dehydrogenase
C6993_RS05190	COG3093	addiction module antidote protein HigA
C6993_RS05195	COG1064	alcohol dehydrogenase
C6993_RS05220	COG1764	response to oxidative stress
C6993_RS05225	COG4608	Belongs to the ABC transporter superfamily
C6993_RS05230	COG0444	Belongs to the ABC transporter superfamily
C6993_RS05235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6993_RS05240	COG0601	transmembrane transport
C6993_RS05245	COG0747	negative chemotaxis
C6993_RS05250	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C6993_RS05255	COG2202	Pas domain
C6993_RS05255	COG2200	EAL domain
C6993_RS05255	COG2199	diguanylate cyclase activity
C6993_RS05265	COG1649	PFAM Uncharacterised BCR, COG1649
C6993_RS05270	COG0531	amino acid
C6993_RS05275	COG0076	glutamate decarboxylase activity
C6993_RS05280	COG0612	Peptidase, M16
C6993_RS05285	COG4771	TonB-dependent receptor
C6993_RS05290	COG4178	(ABC) transporter
C6993_RS05295	COG0641	radical SAM
C6993_RS05300	COG3119	arylsulfatase activity
C6993_RS05305	COG2207	Transcriptional regulator
C6993_RS05315	COG0243	molybdopterin cofactor binding
C6993_RS05325	COG3539	Fimbrial protein
C6993_RS05330	COG3539	Fimbrial protein
C6993_RS05335	COG3539	Fimbrial protein
C6993_RS05340	COG3188	usher protein
C6993_RS05350	COG3539	Fimbrial protein
C6993_RS05370	COG3550	peptidyl-serine autophosphorylation
C6993_RS05375	COG1396	sequence-specific DNA binding
C6993_RS05425	COG3781	membrane
C6993_RS05445	COG2199	diguanylate cyclase activity
C6993_RS05460	COG2066	Belongs to the glutaminase family
C6993_RS05465	COG1012	belongs to the aldehyde dehydrogenase family
C6993_RS05470	COG0583	DNA-binding transcription factor activity
C6993_RS05495	COG1846	Transcriptional regulator
C6993_RS05500	COG4977	sequence-specific DNA binding
C6993_RS05535	COG1447	Phosphotransferase system cellobiose-specific component IIA
C6993_RS05540	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6993_RS05550	COG2188	Transcriptional regulator
C6993_RS05555	COG0697	spore germination
C6993_RS05560	COG2814	Major facilitator Superfamily
C6993_RS05585	COG3111	PFAM Bacterial OB fold (BOF) protein
C6993_RS05590	COG1546	Belongs to the CinA family
C6993_RS05600	COG0339	signal peptide processing
C6993_RS05610	COG4221	oxidoreductase activity
C6993_RS05615	COG1802	Transcriptional regulator
C6993_RS05625	COG0246	Mannitol dehydrogenase
C6993_RS05630	COG0477	Major facilitator Superfamily
C6993_RS05660	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS05800	COG3772	lysozyme
C6993_RS05900	COG1846	Transcriptional regulator
C6993_RS05905	COG1484	DNA-dependent DNA replication
C6993_RS05910	COG3756	Protein conserved in bacteria
C6993_RS05970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6993_RS05975	COG3723	Recombinational DNA repair protein, rece pathway
C6993_RS05995	COG0582	viral genome integration into host DNA
C6993_RS06005	COG0513	Belongs to the DEAD box helicase family
C6993_RS06020	COG3706	GGDEF domain
C6993_RS06025	COG2840	Smr protein MutS2
C6993_RS06030	COG0583	DNA-binding transcription factor activity
C6993_RS06035	COG1473	amidohydrolase
C6993_RS06045	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
C6993_RS06050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6993_RS06055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6993_RS06060	COG0589	response to stress
C6993_RS06065	COG3182	Iron-regulated membrane protein
C6993_RS06070	COG0668	transmembrane transport
C6993_RS06075	COG4166	transmembrane transport
C6993_RS06080	COG0583	DNA-binding transcription factor activity
C6993_RS06085	COG1073	alpha beta
C6993_RS06090	COG1073	alpha beta
C6993_RS06095	COG0702	epimerase
C6993_RS06100	COG2866	Carboxypeptidase
C6993_RS06105	COG4948	Mandelate Racemase Muconate Lactonizing
C6993_RS06110	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C6993_RS06115	COG3283	Transcriptional regulator of aromatic amino acids metabolism
C6993_RS06125	COG3106	COG3106 Predicted ATPase
C6993_RS06130	COG1609	Transcriptional regulator
C6993_RS06140	COG3842	ATPase activity
C6993_RS06145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6993_RS06150	COG1554	hydrolase, family 65, central catalytic
C6993_RS06155	COG0673	inositol 2-dehydrogenase activity
C6993_RS06160	COG1082	Xylose isomerase domain protein TIM barrel
C6993_RS06165	COG1063	alcohol dehydrogenase
C6993_RS06170	COG0395	ABC-type sugar transport system, permease component
C6993_RS06175	COG1175	transmembrane transport
C6993_RS06180	COG1653	transport
C6993_RS06190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6993_RS06200	COG1983	PspC domain protein
C6993_RS06210	COG1842	Phage shock protein A
C6993_RS06215	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C6993_RS06220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6993_RS06225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6993_RS06230	COG1012	belongs to the aldehyde dehydrogenase family
C6993_RS06240	COG1917	Cupin 2, conserved barrel domain protein
C6993_RS06240	COG1396	sequence-specific DNA binding
C6993_RS06245	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6993_RS06250	COG0174	glutamine synthetase
C6993_RS06255	COG0531	amino acid
C6993_RS06270	COG4166	transmembrane transport
C6993_RS06275	COG4168	peptide transport system, permease
C6993_RS06280	COG4171	peptide transport system, permease
C6993_RS06285	COG4172	Belongs to the ABC transporter superfamily
C6993_RS06290	COG4172	Belongs to the ABC transporter superfamily
C6993_RS06295	COG2852	Protein conserved in bacteria
C6993_RS06300	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C6993_RS06320	COG5001	Diguanylate cyclase
C6993_RS06330	COG1349	DNA-binding transcription factor activity
C6993_RS06340	COG0023	Translation Initiation Factor
C6993_RS06350	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C6993_RS06355	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
C6993_RS06360	COG0671	phosphoesterase, PA-phosphatase related
C6993_RS06370	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C6993_RS06390	COG0583	DNA-binding transcription factor activity
C6993_RS06400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6993_RS06415	COG0616	signal peptide processing
C6993_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS06425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
C6993_RS06430	COG1187	pseudouridine synthase activity
C6993_RS06435	COG0009	L-threonylcarbamoyladenylate synthase
C6993_RS06440	COG0613	PHP domain protein
C6993_RS06450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6993_RS06455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6993_RS06455	COG0512	Glutamine amidotransferase of anthranilate synthase
C6993_RS06460	COG0134	indole-3-glycerol-phosphate synthase activity
C6993_RS06460	COG0135	phosphoribosylanthranilate isomerase activity
C6993_RS06475	COG3729	General stress protein
C6993_RS06480	COG3685	Protein conserved in bacteria
C6993_RS06485	COG3685	Protein conserved in bacteria
C6993_RS06585	COG3436	PFAM IS66 Orf2 family protein
C6993_RS06590	COG4372	Transposase
C6993_RS06595	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS06610	COG4372	Transposase
C6993_RS06615	COG3436	PFAM IS66 Orf2 family protein
C6993_RS06765	COG3772	lysozyme
C6993_RS06835	COG0582	viral genome integration into host DNA
C6993_RS06840	COG0784	Response regulator, receiver
C6993_RS06840	COG2205	protein histidine kinase activity
C6993_RS06840	COG2198	Histidine kinase
C6993_RS06845	COG0348	domain, Protein
C6993_RS06865	COG1278	Cold shock
C6993_RS06870	COG1278	Cold shock
C6993_RS06890	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6993_RS06895	COG1596	polysaccharide export
C6993_RS06900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6993_RS06905	COG3206	protein involved in exopolysaccharide biosynthesis
C6993_RS06905	COG0489	protein tyrosine kinase activity
C6993_RS06920	COG1294	oxidase, subunit
C6993_RS06930	COG1773	rubredoxin
C6993_RS06935	COG1999	signal sequence binding
C6993_RS06940	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C6993_RS06945	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
C6993_RS06950	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C6993_RS06955	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C6993_RS06990	COG4372	Transposase
C6993_RS06995	COG3436	PFAM IS66 Orf2 family protein
C6993_RS07010	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS07095	COG1030	water channel activity
C6993_RS07115	COG4220	transposase activity
C6993_RS07155	COG0484	heat shock protein binding
C6993_RS07160	COG1403	HNH endonuclease
C6993_RS07205	COG1846	Transcriptional regulator
C6993_RS07210	COG1484	DNA-dependent DNA replication
C6993_RS07215	COG1846	Transcriptional regulator
C6993_RS07230	COG1396	sequence-specific DNA binding
C6993_RS07265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6993_RS07275	COG0582	viral genome integration into host DNA
C6993_RS07285	COG1063	alcohol dehydrogenase
C6993_RS07290	COG4948	Mandelate Racemase Muconate Lactonizing
C6993_RS07310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6993_RS07330	COG0243	molybdopterin cofactor binding
C6993_RS07335	COG0437	4 iron, 4 sulfur cluster binding
C6993_RS07340	COG3302	dmso reductase anchor subunit
C6993_RS07345	COG3381	protein complex oligomerization
C6993_RS07355	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C6993_RS07360	COG1940	carbohydrate kinase activity
C6993_RS07365	COG0583	DNA-binding transcription factor activity
C6993_RS07370	COG2814	Major facilitator Superfamily
C6993_RS07390	COG3591	Belongs to the peptidase S1B family
C6993_RS07420	COG4626	Terminase
C6993_RS07420	COG1802	Transcriptional regulator
C6993_RS07540	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
C6993_RS07545	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C6993_RS07560	COG0531	amino acid
C6993_RS07570	COG3136	membrane protein required for alginate biosynthesis
C6993_RS07575	COG0745	RESPONSE REGULATOR receiver
C6993_RS07580	COG2205	protein histidine kinase activity
C6993_RS07590	COG0114	fumarate hydratase activity
C6993_RS07595	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C6993_RS07595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C6993_RS07600	COG1482	cell wall glycoprotein biosynthetic process
C6993_RS07605	COG5339	Protein conserved in bacteria
C6993_RS07620	COG3250	beta-galactosidase activity
C6993_RS07625	COG1309	transcriptional regulator
C6993_RS07630	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS07635	COG1609	Transcriptional regulator
C6993_RS07640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS07640	COG1263	PTS System
C6993_RS07645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C6993_RS07655	COG0673	inositol 2-dehydrogenase activity
C6993_RS07700	COG4659	FMN binding
C6993_RS07710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C6993_RS07720	COG3104	oligopeptide transport
C6993_RS07725	COG0625	glutathione transferase activity
C6993_RS07730	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
C6993_RS07745	COG3895	Periplasmic Protein
C6993_RS07755	COG3133	Outer membrane lipoprotein
C6993_RS07770	COG1566	PFAM secretion protein HlyD family protein
C6993_RS07775	COG1289	transmembrane transporter activity
C6993_RS07780	COG2032	superoxide dismutase activity
C6993_RS07785	COG4989	oxidoreductase activity
C6993_RS07790	COG3313	Fe-S protein
C6993_RS07795	COG1309	transcriptional regulator
C6993_RS07800	COG1902	pentaerythritol trinitrate reductase activity
C6993_RS07805	COG0346	lactoylglutathione lyase activity
C6993_RS07815	COG1201	RNA secondary structure unwinding
C6993_RS07820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C6993_RS07825	COG0791	NLP P60 protein
C6993_RS07830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C6993_RS07835	COG2814	Major facilitator Superfamily
C6993_RS07855	COG0583	DNA-binding transcription factor activity
C6993_RS07860	COG2814	Major facilitator Superfamily
C6993_RS07865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6993_RS07870	COG0307	riboflavin synthase, alpha
C6993_RS07880	COG3468	outer membrane autotransporter barrel domain protein
C6993_RS07900	COG4529	Protein conserved in bacteria
C6993_RS07910	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
C6993_RS07915	COG0437	4 iron, 4 sulfur cluster binding
C6993_RS07925	COG2414	aldehyde ferredoxin oxidoreductase
C6993_RS07930	COG0437	4 iron, 4 sulfur cluster binding
C6993_RS07940	COG0469	pyruvate kinase activity
C6993_RS07945	COG4238	major outer membrane lipoprotein
C6993_RS07950	COG1376	ErfK ybiS ycfS ynhG family protein
C6993_RS07965	COG0719	Fe-S assembly protein
C6993_RS07970	COG0396	ATPase activity
C6993_RS07975	COG0719	Fe-S assembly protein
C6993_RS07980	COG0316	Belongs to the HesB IscA family
C6993_RS07990	COG2050	protein possibly involved in aromatic compounds catabolism
C6993_RS07995	COG0247	lactate metabolic process
C6993_RS07995	COG0277	FAD linked oxidase domain protein
C6993_RS08005	COG0628	permease
C6993_RS08020	COG0738	Major facilitator superfamily
C6993_RS08025	COG2271	Major facilitator Superfamily
C6993_RS08045	COG1960	acyl-CoA dehydrogenase activity
C6993_RS08050	COG1917	Cupin 2, conserved barrel domain protein
C6993_RS08050	COG2207	Transcriptional regulator
C6993_RS08060	COG2086	electron transfer activity
C6993_RS08065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C6993_RS08070	COG0644	oxidoreductase
C6993_RS08075	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C6993_RS08080	COG0318	PFAM AMP-dependent synthetase and ligase
C6993_RS08085	COG0574	Belongs to the PEP-utilizing enzyme family
C6993_RS08085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6993_RS08100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C6993_RS08105	COG4256	Hemin uptake protein
C6993_RS08115	COG2200	EAL domain
C6993_RS08120	COG0791	NLP P60 protein
C6993_RS08130	COG0386	Belongs to the glutathione peroxidase family
C6993_RS08190	COG3137	Salt-induced outer membrane protein
C6993_RS08195	COG1105	Belongs to the carbohydrate kinase PfkB family
C6993_RS08205	COG3001	Fructosamine kinase
C6993_RS08215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6993_RS08220	COG1988	membrane-bound metal-dependent
C6993_RS08225	COG1823	symporter activity
C6993_RS08245	COG0753	catalase activity
C6993_RS08255	COG1486	melibiose metabolic process
C6993_RS08260	COG2169	Transcriptional regulator
C6993_RS08260	COG1917	Cupin 2, conserved barrel domain protein
C6993_RS08265	COG1447	Phosphotransferase system cellobiose-specific component IIA
C6993_RS08270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6993_RS08275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C6993_RS08285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6993_RS08295	COG0322	excinuclease ABC activity
C6993_RS08305	COG3678	ATP-independent chaperone mediated protein folding
C6993_RS08340	COG0708	Exodeoxyribonuclease III
C6993_RS08345	COG0398	Pfam SNARE associated Golgi protein
C6993_RS08355	COG0398	Pfam SNARE associated Golgi protein
C6993_RS08360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6993_RS08365	COG4134	Bacterial extracellular solute-binding protein
C6993_RS08370	COG4135	transport system, permease component
C6993_RS08375	COG4136	ATPase activity
C6993_RS08380	COG2897	thiosulfate sulfurtransferase activity
C6993_RS08385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C6993_RS08390	COG0494	nUDIX hydrolase
C6993_RS08400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C6993_RS08410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6993_RS08425	COG0778	Nitroreductase
C6993_RS08435	COG0616	signal peptide processing
C6993_RS08440	COG0252	asparaginase activity
C6993_RS08445	COG1335	isochorismatase
C6993_RS08450	COG3139	Protein of unknown function (DUF1315)
C6993_RS08460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6993_RS08465	COG0676	glucose-6-phosphate 1-epimerase activity
C6993_RS08470	COG0656	L-ascorbic acid biosynthetic process
C6993_RS08475	COG3713	MltA-interacting MipA family protein
C6993_RS08480	COG2766	serine protein kinase
C6993_RS08490	COG2199	diguanylate cyclase activity
C6993_RS08495	COG2199	diguanylate cyclase activity
C6993_RS08500	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C6993_RS08515	COG2207	Transcriptional regulator
C6993_RS08520	COG2807	transmembrane transport
C6993_RS08525	COG3189	MarR family transcriptional regulator
C6993_RS08530	COG3042	response to heat
C6993_RS08535	COG2199	diguanylate cyclase activity
C6993_RS08535	COG2203	Gaf domain
C6993_RS08550	COG2261	transglycosylase associated protein
C6993_RS08555	COG0675	Transposase, IS605 OrfB family
C6993_RS08570	COG3615	Tellurite resistance protein tehB
C6993_RS08580	COG0583	DNA-binding transcription factor activity
C6993_RS08585	COG0473	3-isopropylmalate dehydrogenase activity
C6993_RS08590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6993_RS08595	COG4638	Rieske (2fe-2S)
C6993_RS08600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6993_RS08605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C6993_RS08610	COG0318	PFAM AMP-dependent synthetase and ligase
C6993_RS08615	COG3065	identical protein binding
C6993_RS08620	COG1214	PFAM Peptidase M22, glycoprotease
C6993_RS08625	COG1199	ATP-dependent helicase activity
C6993_RS08630	COG0251	oxidation-reduction process
C6993_RS08645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C6993_RS08655	COG1760	l-serine dehydratase
C6993_RS08660	COG2200	EAL domain
C6993_RS08680	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS08680	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS08685	COG3715	PTS system
C6993_RS08690	COG3716	PTS system mannose fructose sorbose family IID component
C6993_RS08710	COG2226	methyltransferase
C6993_RS08745	COG1414	Transcriptional regulator
C6993_RS08750	COG2814	Major facilitator Superfamily
C6993_RS08760	COG0793	Belongs to the peptidase S41A family
C6993_RS08770	COG1956	GAF domain-containing protein
C6993_RS08775	COG2995	paraquat-inducible protein a
C6993_RS08780	COG3008	intermembrane lipid transfer
C6993_RS08800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C6993_RS08830	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS08920	COG1030	water channel activity
C6993_RS08940	COG4220	transposase activity
C6993_RS08970	COG3772	lysozyme
C6993_RS09000	COG0484	heat shock protein binding
C6993_RS09005	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C6993_RS09010	COG1403	HNH endonuclease
C6993_RS09020	COG3111	PFAM Bacterial OB fold (BOF) protein
C6993_RS09055	COG1846	Transcriptional regulator
C6993_RS09065	COG1846	Transcriptional regulator
C6993_RS09115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6993_RS09120	COG3723	Recombinational DNA repair protein, rece pathway
C6993_RS09140	COG0582	viral genome integration into host DNA
C6993_RS09150	COG1276	copper resistance
C6993_RS09155	COG2372	response to copper ion
C6993_RS09165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6993_RS09170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6993_RS09175	COG1770	oligopeptidase
C6993_RS09180	COG2979	Protein of unknown function (DUF533)
C6993_RS09190	COG3141	response to X-ray
C6993_RS09200	COG0800	Aldolase
C6993_RS09205	COG0129	dihydroxy-acid dehydratase activity
C6993_RS09210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C6993_RS09215	COG1737	Transcriptional regulator
C6993_RS09220	COG0469	pyruvate kinase activity
C6993_RS09245	COG3833	ABC-type maltose transport systems, permease component
C6993_RS09250	COG1175	transmembrane transport
C6993_RS09255	COG2182	Extracellular solute-binding protein
C6993_RS09265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6993_RS09275	COG3842	ATPase activity
C6993_RS09295	COG1560	Kdo2-lipid A biosynthetic process
C6993_RS09300	COG0739	heme binding
C6993_RS09305	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C6993_RS09315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6993_RS09345	COG0217	transcriptional regulatory protein
C6993_RS09350	COG0494	nUDIX hydrolase
C6993_RS09360	COG1335	isochorismatase
C6993_RS09365	COG1801	Protein of unknown function DUF72
C6993_RS09370	COG3788	relative of glutathione S-transferase, MAPEG superfamily
C6993_RS09385	COG0243	molybdopterin cofactor binding
C6993_RS09390	COG3005	denitrification pathway
C6993_RS09400	COG3102	Protein conserved in bacteria
C6993_RS09415	COG3755	Protein conserved in bacteria
C6993_RS09425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C6993_RS09430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C6993_RS09435	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C6993_RS09440	COG0745	RESPONSE REGULATOR receiver
C6993_RS09445	COG2201	protein-glutamate methylesterase activity
C6993_RS09450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C6993_RS09455	COG0840	transmembrane signaling receptor activity
C6993_RS09460	COG0840	transmembrane signaling receptor activity
C6993_RS09465	COG0835	chemotaxis
C6993_RS09470	COG2198	Histidine kinase
C6993_RS09470	COG0643	Histidine kinase
C6993_RS09475	COG1360	Flagellar Motor Protein
C6993_RS09480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C6993_RS09495	COG0589	response to stress
C6993_RS09505	COG1877	trehalose-phosphatase activity
C6993_RS09510	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6993_RS09515	COG1129	ABC transporter
C6993_RS09520	COG1879	ABC-type sugar transport system periplasmic component
C6993_RS09530	COG1528	Iron-storage protein
C6993_RS09550	COG1528	Iron-storage protein
C6993_RS09560	COG0814	amino acid
C6993_RS09565	COG3318	Belongs to the UPF0149 family
C6993_RS09565	COG3012	SEC-C Motif Domain Protein
C6993_RS09570	COG4974	Belongs to the 'phage' integrase family
C6993_RS09650	COG4695	Portal protein
C6993_RS09735	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS09740	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C6993_RS09835	COG2197	response regulator
C6993_RS09850	COG2197	response regulator
C6993_RS09855	COG1126	abc transporter atp-binding protein
C6993_RS09860	COG0765	amino acid transport
C6993_RS09870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6993_RS09880	COG1191	sigma factor activity
C6993_RS09895	COG1516	flagellar protein fliS
C6993_RS09905	COG0366	Alpha amylase catalytic
C6993_RS09920	COG2391	methyltransferase activity
C6993_RS09925	COG0425	Belongs to the sulfur carrier protein TusA family
C6993_RS09930	COG2135	peptidase activity
C6993_RS09945	COG1766	The M ring may be actively involved in energy transduction
C6993_RS09950	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C6993_RS09955	COG1317	bacterial-type flagellum organization
C6993_RS09960	COG1157	protein secretion by the type III secretion system
C6993_RS09965	COG2882	bacterial-type flagellum organization
C6993_RS09970	COG3144	bacterial-type flagellum assembly
C6993_RS09975	COG1580	Controls the rotational direction of flagella during chemotaxis
C6993_RS09980	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C6993_RS09985	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C6993_RS09990	COG3190	flagellar
C6993_RS09995	COG1338	Plays a role in the flagellum-specific transport system
C6993_RS10000	COG1987	bacterial-type flagellum assembly
C6993_RS10005	COG1684	flagellar biosynthetic protein fliR
C6993_RS10010	COG2197	response regulator
C6993_RS10045	COG5475	Uncharacterized small protein (DUF2158)
C6993_RS10050	COG2354	Protein conserved in bacteria
C6993_RS10055	COG0697	spore germination
C6993_RS10060	COG3727	T/G mismatch-specific endonuclease activity
C6993_RS10065	COG0270	DNA (cytosine-5-)-methyltransferase activity
C6993_RS10085	COG2205	protein histidine kinase activity
C6993_RS10090	COG0745	RESPONSE REGULATOR receiver
C6993_RS10095	COG2351	hydroxyisourate hydrolase activity
C6993_RS10110	COG3443	Belongs to the bacterial solute-binding protein 9 family
C6993_RS10140	COG1169	isochorismate synthase
C6993_RS10145	COG2814	Major facilitator Superfamily
C6993_RS10150	COG1132	(ABC) transporter
C6993_RS10165	COG2226	methyltransferase
C6993_RS10165	COG3433	isochorismatase activity
C6993_RS10165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6993_RS10185	COG1021	2,3-dihydroxybenzoate-AMP ligase
C6993_RS10190	COG4771	TonB-dependent receptor
C6993_RS10195	COG1388	LysM domain
C6993_RS10195	COG2373	Large extracellular alpha-helical protein
C6993_RS10195	COG4932	domain protein
C6993_RS10200	COG1388	LysM domain
C6993_RS10200	COG1470	cell adhesion involved in biofilm formation
C6993_RS10205	COG1388	LysM domain
C6993_RS10205	COG1470	cell adhesion involved in biofilm formation
C6993_RS10210	COG1388	LysM domain
C6993_RS10210	COG1470	cell adhesion involved in biofilm formation
C6993_RS10220	COG0477	Major facilitator Superfamily
C6993_RS10225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C6993_RS10230	COG0217	transcriptional regulatory protein
C6993_RS10245	COG0534	Mate efflux family protein
C6993_RS10255	COG0583	DNA-binding transcription factor activity
C6993_RS10260	COG0583	DNA-binding transcription factor activity
C6993_RS10270	COG1376	ErfK ybiS ycfS ynhG family protein
C6993_RS10285	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
C6993_RS10305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6993_RS10320	COG1735	metal-dependent hydrolase with the TIM-barrel fold
C6993_RS10385	COG4983	Phage plasmid primase, P4 family domain protein
C6993_RS10400	COG3468	outer membrane autotransporter barrel domain protein
C6993_RS10435	COG2003	Belongs to the UPF0758 family
C6993_RS10470	COG4917	ethanolamine utilization protein
C6993_RS10480	COG1289	transmembrane transporter activity
C6993_RS10490	COG1686	Belongs to the peptidase S11 family
C6993_RS10495	COG2925	Exonuclease
C6993_RS10500	COG0425	Belongs to the sulfur carrier protein TusA family
C6993_RS10505	COG2391	methyltransferase activity
C6993_RS10510	COG0531	amino acid
C6993_RS10520	COG0583	DNA-binding transcription factor activity
C6993_RS10525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6993_RS10530	COG4115	mRNA cleavage
C6993_RS10535	COG2161	toxin-antitoxin pair type II binding
C6993_RS10555	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C6993_RS10565	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C6993_RS10565	COG0131	Imidazoleglycerol-phosphate dehydratase
C6993_RS10570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C6993_RS10595	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C6993_RS10600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C6993_RS10605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C6993_RS10650	COG1216	Glycosyl transferase, family 2
C6993_RS10660	COG1091	dTDP-4-dehydrorhamnose reductase activity
C6993_RS10665	COG1088	dTDP-glucose 4,6-dehydratase activity
C6993_RS10675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C6993_RS10680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6993_RS10690	COG0438	transferase activity, transferring glycosyl groups
C6993_RS10695	COG2327	Polysaccharide pyruvyl transferase
C6993_RS10700	COG2244	polysaccharide biosynthetic process
C6993_RS10705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6993_RS10710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6993_RS10715	COG0662	Cupin 2, conserved barrel domain protein
C6993_RS10715	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C6993_RS10720	COG0297	glycogen (starch) synthase activity
C6993_RS10725	COG1051	belongs to the nudix hydrolase family
C6993_RS10730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6993_RS10735	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C6993_RS10740	COG0110	maltose O-acetyltransferase activity
C6993_RS10745	COG1216	Glycosyl transferase, family 2
C6993_RS10755	COG0438	transferase activity, transferring glycosyl groups
C6993_RS10760	COG1045	serine acetyltransferase
C6993_RS10765	COG0463	Glycosyl transferase, family 2
C6993_RS10770	COG0489	protein tyrosine kinase activity
C6993_RS10770	COG3206	protein involved in exopolysaccharide biosynthesis
C6993_RS10775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6993_RS10780	COG1596	polysaccharide export
C6993_RS10785	COG1253	flavin adenine dinucleotide binding
C6993_RS10790	COG2982	Protein involved in outer membrane biogenesis
C6993_RS10800	COG0572	uridine kinase
C6993_RS10805	COG3447	MASE1 domain protein
C6993_RS10805	COG5002	protein histidine kinase activity
C6993_RS10805	COG5001	Diguanylate cyclase
C6993_RS10810	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C6993_RS10820	COG0443	Heat shock 70 kDa protein
C6993_RS10825	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
C6993_RS10830	COG3779	Protein conserved in bacteria
C6993_RS10835	COG0631	protein serine/threonine phosphatase activity
C6993_RS10840	COG4245	von Willebrand factor, type A
C6993_RS10875	COG2205	protein histidine kinase activity
C6993_RS10880	COG0745	RESPONSE REGULATOR receiver
C6993_RS10890	COG0826	peptidase U32
C6993_RS10920	COG3775	system Galactitol-specific IIC component
C6993_RS10925	COG3414	Phosphotransferase system galactitol-specific IIB component
C6993_RS10930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS10945	COG1830	Aldolase
C6993_RS10950	COG2211	Major facilitator Superfamily
C6993_RS10955	COG1397	ADP-ribosylglycohydrolase
C6993_RS10960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6993_RS10965	COG2188	Transcriptional regulator
C6993_RS10970	COG3757	hydrolase, family 25
C6993_RS10975	COG0351	phosphomethylpyrimidine kinase
C6993_RS10990	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C6993_RS10995	COG5455	response to cobalt ion
C6993_RS11000	COG3539	Fimbrial protein
C6993_RS11005	COG3188	usher protein
C6993_RS11010	COG3121	Chaperone
C6993_RS11015	COG3539	Fimbrial protein
C6993_RS11030	COG0489	protein tyrosine kinase activity
C6993_RS11045	COG3831	ATPase activity
C6993_RS11055	COG0714	Associated with various cellular activities
C6993_RS11060	COG2425	protein containing a von Willebrand factor type A (vWA) domain
C6993_RS11065	COG3552	Protein containing von Willebrand factor type A (VWA) domain
C6993_RS11070	COG4715	Zinc finger, swim domain protein
C6993_RS11080	COG3436	PFAM IS66 Orf2 family protein
C6993_RS11085	COG4372	Transposase
C6993_RS11095	COG4807	Protein conserved in bacteria
C6993_RS11100	COG3279	Response regulator of the LytR AlgR family
C6993_RS11105	COG3275	phosphorelay sensor kinase activity
C6993_RS11110	COG0789	Transcriptional regulator
C6993_RS11120	COG1174	glycine betaine transport
C6993_RS11125	COG1125	glycine betaine transport
C6993_RS11130	COG1174	glycine betaine transport
C6993_RS11135	COG1732	Glycine betaine
C6993_RS11140	COG1472	Belongs to the glycosyl hydrolase 3 family
C6993_RS11145	COG0277	FAD linked oxidase domain protein
C6993_RS11150	COG1686	Belongs to the peptidase S11 family
C6993_RS11160	COG0586	Pfam SNARE associated Golgi protein
C6993_RS11165	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS11190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6993_RS11200	COG1346	cytolysis
C6993_RS11210	COG2949	membrane
C6993_RS11220	COG0493	'glutamate synthase
C6993_RS11225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C6993_RS11225	COG0167	dihydroorotate dehydrogenase activity
C6993_RS11230	COG4211	Belongs to the binding-protein-dependent transport system permease family
C6993_RS11235	COG1129	ABC transporter
C6993_RS11240	COG1879	ABC-type sugar transport system periplasmic component
C6993_RS11245	COG1609	Transcriptional regulator
C6993_RS11255	COG2311	Membrane
C6993_RS11280	COG4771	TonB-dependent receptor
C6993_RS11290	COG0833	amino acid
C6993_RS11300	COG0583	DNA-binding transcription factor activity
C6993_RS11305	COG2855	membrane
C6993_RS11315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6993_RS11315	COG1522	sequence-specific DNA binding
C6993_RS11320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C6993_RS11330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6993_RS11335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C6993_RS11340	COG2313	pseudouridylate synthase activity
C6993_RS11345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6993_RS11350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS11350	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C6993_RS11350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS11355	COG1105	Belongs to the carbohydrate kinase PfkB family
C6993_RS11360	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS11360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS11365	COG2814	Major facilitator Superfamily
C6993_RS11380	COG0246	Mannitol dehydrogenase
C6993_RS11385	COG0523	cobalamin synthesis protein
C6993_RS11390	COG0671	phosphoesterase, PA-phosphatase related
C6993_RS11395	COG0791	NLP P60 protein
C6993_RS11400	COG2200	EAL domain
C6993_RS11405	COG4166	transmembrane transport
C6993_RS11410	COG4174	ABC transporter (Permease)
C6993_RS11415	COG4239	(ABC) transporter, permease
C6993_RS11420	COG4172	Belongs to the ABC transporter superfamily
C6993_RS11435	COG2814	Major facilitator Superfamily
C6993_RS11440	COG1187	pseudouridine synthase activity
C6993_RS11450	COG1061	Type III restriction enzyme res subunit
C6993_RS11470	COG3083	sulfuric ester hydrolase activity
C6993_RS11480	COG0582	viral genome integration into host DNA
C6993_RS11570	COG2197	response regulator
C6993_RS11575	COG3088	subunit of a heme lyase
C6993_RS11575	COG4235	cytochrome complex assembly
C6993_RS11580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6993_RS11585	COG1138	Cytochrome C-type biogenesis protein
C6993_RS11595	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6993_RS11600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6993_RS11605	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C6993_RS11610	COG4133	protoheme IX ABC transporter activity
C6993_RS11615	COG3005	denitrification pathway
C6993_RS11620	COG3043	anaerobic respiration
C6993_RS11625	COG0348	domain, Protein
C6993_RS11630	COG0437	4 iron, 4 sulfur cluster binding
C6993_RS11640	COG3062	negative regulation of establishment of protein localization
C6993_RS11645	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6993_RS11645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6993_RS11665	COG4615	Cyclic peptide transporter
C6993_RS11670	COG3145	DNA-N1-methyladenine dioxygenase activity
C6993_RS11675	COG2169	Transcriptional regulator
C6993_RS11675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6993_RS11680	COG1477	protein flavinylation
C6993_RS11685	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C6993_RS11700	COG0642	Histidine kinase
C6993_RS11700	COG2198	Histidine kinase
C6993_RS11705	COG2197	response regulator
C6993_RS11710	COG0784	Response regulator, receiver
C6993_RS11710	COG2205	protein histidine kinase activity
C6993_RS11715	COG4676	Protein conserved in bacteria
C6993_RS11720	COG5445	Predicted secreted protein (DUF2300)
C6993_RS11725	COG2373	Large extracellular alpha-helical protein
C6993_RS11760	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS11775	COG4372	Transposase
C6993_RS11780	COG3436	PFAM IS66 Orf2 family protein
C6993_RS11885	COG4220	transposase activity
C6993_RS11905	COG3772	lysozyme
C6993_RS12100	COG0582	viral genome integration into host DNA
C6993_RS12105	COG3234	Protein of unknown function (DUF1175)
C6993_RS12110	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
C6993_RS12115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6993_RS12135	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6993_RS12140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6993_RS12145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6993_RS12150	COG3642	lipopolysaccharide core region biosynthetic process
C6993_RS12155	COG0583	DNA-binding transcription factor activity
C6993_RS12160	COG0584	glycerophosphoryl diester phosphodiesterase
C6993_RS12165	COG2271	Major facilitator Superfamily
C6993_RS12170	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C6993_RS12180	COG0247	lactate metabolic process
C6993_RS12185	COG5464	transposase or invertase
C6993_RS12255	COG0318	PFAM AMP-dependent synthetase and ligase
C6993_RS12265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C6993_RS12280	COG1169	isochorismate synthase
C6993_RS12285	COG4575	ribosome binding
C6993_RS12290	COG2153	protein acetylation
C6993_RS12305	COG2304	oxidoreductase activity
C6993_RS12310	COG2234	aminopeptidase activity
C6993_RS12325	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6993_RS12330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6993_RS12340	COG0839	Belongs to the complex I subunit 6 family
C6993_RS12355	COG1034	ATP synthesis coupled electron transport
C6993_RS12360	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C6993_RS12365	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C6993_RS12385	COG0583	DNA-binding transcription factor activity
C6993_RS12395	COG0436	Aminotransferase
C6993_RS12405	COG0471	metal ion transport
C6993_RS12405	COG0490	domain, Protein
C6993_RS12410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6993_RS12425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6993_RS12430	COG0857	belongs to the CobB CobQ family
C6993_RS12430	COG0280	phosphate acetyltransferase
C6993_RS12435	COG1288	antiporter activity
C6993_RS12440	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C6993_RS12445	COG0622	Phosphoesterase
C6993_RS12450	COG0625	glutathione transferase activity
C6993_RS12455	COG0625	glutathione transferase activity
C6993_RS12460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6993_RS12465	COG1090	epimerase
C6993_RS12470	COG5464	transposase or invertase
C6993_RS12475	COG4598	ABC transporter
C6993_RS12480	COG4160	amino acid transport
C6993_RS12485	COG4215	(ABC) transporter
C6993_RS12490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6993_RS12495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6993_RS12500	COG0163	prenyltransferase activity
C6993_RS12505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C6993_RS12510	COG1286	toxin biosynthetic process
C6993_RS12515	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
C6993_RS12520	COG0285	dihydrofolate synthase activity
C6993_RS12530	COG0586	Pfam SNARE associated Golgi protein
C6993_RS12540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C6993_RS12555	COG2814	Major facilitator Superfamily
C6993_RS12565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6993_RS12580	COG3101	peptidyl-lysine hydroxylation
C6993_RS12585	COG0730	response to heat
C6993_RS12615	COG3539	Fimbrial protein
C6993_RS12620	COG3539	Fimbrial protein
C6993_RS12625	COG3539	Fimbrial protein
C6993_RS12630	COG3121	Chaperone
C6993_RS12635	COG3188	usher protein
C6993_RS12640	COG3539	Fimbrial protein
C6993_RS12645	COG2062	phosphohistidine phosphatase, SixA
C6993_RS12660	COG3691	Protein conserved in bacteria
C6993_RS12670	COG2067	long-chain fatty acid transport protein
C6993_RS12685	COG2853	Lipoprotein
C6993_RS12695	COG2116	formate transmembrane transporter activity
C6993_RS12735	COG3436	PFAM IS66 Orf2 family protein
C6993_RS12740	COG4372	Transposase
C6993_RS12795	COG3468	outer membrane autotransporter barrel domain protein
C6993_RS12815	COG2003	Belongs to the UPF0758 family
C6993_RS12860	COG0477	Major facilitator Superfamily
C6993_RS12865	COG1566	PFAM secretion protein HlyD family protein
C6993_RS12870	COG2197	response regulator
C6993_RS12875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6993_RS12875	COG0784	Response regulator, receiver
C6993_RS12875	COG2205	protein histidine kinase activity
C6993_RS12875	COG2198	Histidine kinase
C6993_RS12880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6993_RS12885	COG0679	Auxin Efflux Carrier
C6993_RS12890	COG0028	Belongs to the TPP enzyme family
C6993_RS12920	COG1560	Kdo2-lipid A biosynthetic process
C6993_RS12930	COG0436	Aminotransferase
C6993_RS12935	COG3275	phosphorelay sensor kinase activity
C6993_RS12940	COG3279	Response regulator of the LytR AlgR family
C6993_RS12945	COG2207	Transcriptional regulator
C6993_RS12955	COG1363	Peptidase, m42
C6993_RS12960	COG0006	proline dipeptidase activity
C6993_RS12965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS12970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS12995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C6993_RS13000	COG2199	diguanylate cyclase activity
C6993_RS13000	COG2200	EAL domain
C6993_RS13015	COG3415	Transposase
C6993_RS13020	COG3415	Transposase
C6993_RS13055	COG0583	DNA-binding transcription factor activity
C6993_RS13065	COG2211	Major facilitator Superfamily
C6993_RS13070	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C6993_RS13080	COG0583	DNA-binding transcription factor activity
C6993_RS13085	COG0385	Bile acid
C6993_RS13090	COG3530	Putative quorum-sensing-regulated virulence factor
C6993_RS13110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C6993_RS13115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS13120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6993_RS13125	COG2190	(PTS) system
C6993_RS13140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C6993_RS13145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C6993_RS13150	COG4208	sulfate ABC transporter
C6993_RS13155	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C6993_RS13160	COG4150	thiosulfate binding
C6993_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS13180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS13180	COG1263	PTS System
C6993_RS13185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6993_RS13190	COG2837	iron assimilation
C6993_RS13210	COG0860	N-Acetylmuramoyl-L-alanine amidase
C6993_RS13220	COG2207	Transcriptional regulator
C6993_RS13225	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C6993_RS13230	COG4816	utilization protein
C6993_RS13240	COG4303	Ethanolamine ammonia lyase large subunit
C6993_RS13245	COG4819	ethanolamine utilization protein
C6993_RS13250	COG3192	ethanolamine utilization protein
C6993_RS13255	COG1454	alcohol dehydrogenase
C6993_RS13260	COG4820	ethanolamine utilization protein (EutJ)
C6993_RS13265	COG1012	belongs to the aldehyde dehydrogenase family
C6993_RS13270	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
C6993_RS13275	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
C6993_RS13280	COG0280	phosphate acetyltransferase
C6993_RS13285	COG4812	Cobalamin adenosyltransferase
C6993_RS13290	COG4766	ethanolamine catabolic process
C6993_RS13295	COG4917	ethanolamine utilization protein
C6993_RS13300	COG4810	utilization protein
C6993_RS13310	COG0280	phosphate acetyltransferase
C6993_RS13310	COG0281	malic enzyme
C6993_RS13315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6993_RS13320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C6993_RS13325	COG5342	invasion associated locus B
C6993_RS13340	COG3850	Histidine kinase
C6993_RS13345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6993_RS13360	COG1393	Belongs to the ArsC family
C6993_RS13375	COG0400	carboxylic ester hydrolase activity
C6993_RS13385	COG2321	neutral zinc metallopeptidase
C6993_RS13405	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C6993_RS13415	COG2716	regulation of RNA biosynthetic process
C6993_RS13420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C6993_RS13425	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6993_RS13430	COG0651	ATP synthesis coupled electron transport
C6993_RS13435	COG0650	Formate hydrogenlyase subunit 4
C6993_RS13440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6993_RS13445	COG4237	Hydrogenase 4 membrane
C6993_RS13450	COG0651	ATP synthesis coupled electron transport
C6993_RS13455	COG3261	NADH dehydrogenase
C6993_RS13455	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C6993_RS13460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6993_RS13475	COG3604	Transcriptional regulator
C6993_RS13480	COG2116	formate transmembrane transporter activity
C6993_RS13490	COG0628	permease
C6993_RS13495	COG4783	chaperone-mediated protein folding
C6993_RS13500	COG1393	Belongs to the ArsC family
C6993_RS13510	COG2233	PERMEase
C6993_RS13530	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C6993_RS13535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C6993_RS13540	COG0248	Ppx GppA phosphatase
C6993_RS13545	COG2200	EAL domain
C6993_RS13565	COG3133	Outer membrane lipoprotein
C6993_RS13580	COG0516	GMP reductase activity
C6993_RS13580	COG0517	IMP dehydrogenase activity
C6993_RS13590	COG1645	bacterial-type flagellum-dependent swarming motility
C6993_RS13605	COG2976	Protein conserved in bacteria
C6993_RS13640	COG4953	penicillin-binding protein 1C
C6993_RS13645	COG2373	Large extracellular alpha-helical protein
C6993_RS13650	COG2897	thiosulfate sulfurtransferase activity
C6993_RS13665	COG2975	iron-sulfur cluster assembly
C6993_RS13670	COG0633	Ferredoxin
C6993_RS13690	COG0822	iron-sulfur transferase activity
C6993_RS13710	COG0483	inositol monophosphate 1-phosphatase activity
C6993_RS13715	COG1073	alpha beta
C6993_RS13720	COG3711	transcriptional antiterminator
C6993_RS13725	COG2814	Major facilitator Superfamily
C6993_RS13730	COG0583	DNA-binding transcription factor activity
C6993_RS13735	COG4638	Rieske (2fe-2S)
C6993_RS13760	COG2259	Doxx family
C6993_RS13770	COG1063	alcohol dehydrogenase
C6993_RS13775	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6993_RS13780	COG1129	ABC transporter
C6993_RS13785	COG1879	ABC-type sugar transport system periplasmic component
C6993_RS13795	COG1940	carbohydrate kinase activity
C6993_RS13805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6993_RS13805	COG1017	nitric oxide dioxygenase activity
C6993_RS13810	COG0347	Belongs to the P(II) protein family
C6993_RS13815	COG2204	response regulator
C6993_RS13820	COG3170	Tfp pilus assembly protein FimV
C6993_RS13825	COG2205	protein histidine kinase activity
C6993_RS13830	COG0047	phosphoribosylformylglycinamidine synthase activity
C6993_RS13830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6993_RS13850	COG0560	Phosphoserine phosphatase
C6993_RS13855	COG1737	Transcriptional regulator
C6993_RS13860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6993_RS13885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C6993_RS13910	COG0681	Belongs to the peptidase S26 family
C6993_RS13920	COG3086	response to oxidative stress
C6993_RS13925	COG3026	antisigma factor binding
C6993_RS13930	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
C6993_RS13935	COG1595	DNA-templated transcription, initiation
C6993_RS13940	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C6993_RS13950	COG0513	Belongs to the DEAD box helicase family
C6993_RS13955	COG0583	DNA-binding transcription factor activity
C6993_RS13975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6993_RS13985	COG3118	belongs to the thioredoxin family
C6993_RS13990	COG3148	PFAM DTW domain containing protein
C6993_RS13995	COG0045	succinate-CoA ligase (ADP-forming) activity
C6993_RS13995	COG1042	CoA-binding domain protein
C6993_RS13995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C6993_RS14000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6993_RS14005	COG5544	Lipoprotein
C6993_RS14010	COG0477	Major facilitator Superfamily
C6993_RS14040	COG0542	response to heat
C6993_RS14045	COG1496	oxidoreductase activity
C6993_RS14050	COG0564	pseudouridine synthase activity
C6993_RS14055	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6993_RS14065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C6993_RS14075	COG1605	Chorismate mutase
C6993_RS14075	COG0077	Prephenate dehydratase
C6993_RS14080	COG1605	Chorismate mutase
C6993_RS14080	COG0287	Prephenate dehydrogenase
C6993_RS14085	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C6993_RS14100	COG2199	diguanylate cyclase activity
C6993_RS14105	COG2885	chlorophyll binding
C6993_RS14130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C6993_RS14135	COG4137	Cytochrome C assembly protein
C6993_RS14140	COG4536	flavin adenine dinucleotide binding
C6993_RS14160	COG0497	DNA recombination
C6993_RS14165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6993_RS14175	COG2867	negative regulation of translational initiation
C6993_RS14220	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS14240	COG3436	PFAM IS66 Orf2 family protein
C6993_RS14245	COG4372	Transposase
C6993_RS14390	COG3772	lysozyme
C6993_RS14450	COG1403	HNH endonuclease
C6993_RS14460	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C6993_RS14470	COG4725	Belongs to the MT-A70-like family
C6993_RS14480	COG1846	Transcriptional regulator
C6993_RS14525	COG5532	Uncharacterized conserved protein (DUF2303)
C6993_RS14530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C6993_RS14575	COG0582	viral genome integration into host DNA
C6993_RS14585	COG0582	viral genome integration into host DNA
C6993_RS14620	COG0579	oxidoreductase
C6993_RS14625	COG1012	belongs to the aldehyde dehydrogenase family
C6993_RS14630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6993_RS14635	COG1113	amino acid transport
C6993_RS14640	COG1802	Transcriptional regulator
C6993_RS14645	COG1652	LysM domain
C6993_RS14650	COG0401	homolog of Blt101
C6993_RS14655	COG0640	Transcriptional regulator
C6993_RS14660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6993_RS14665	COG2916	Histone family protein nucleoid-structuring protein H-NS
C6993_RS14680	COG4575	ribosome binding
C6993_RS14685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C6993_RS14695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6993_RS14700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6993_RS14705	COG4175	Glycine betaine
C6993_RS14710	COG4176	ABC-type proline glycine betaine transport system permease component
C6993_RS14715	COG2113	Glycine betaine
C6993_RS14720	COG2814	Major facilitator Superfamily
C6993_RS14725	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C6993_RS14735	COG1846	Transcriptional regulator
C6993_RS14740	COG1566	PFAM secretion protein HlyD family protein
C6993_RS14745	COG2814	Major facilitator Superfamily
C6993_RS14760	COG1238	metal cluster binding
C6993_RS14765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6993_RS14800	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C6993_RS14820	COG1546	Belongs to the CinA family
C6993_RS14825	COG2951	lytic endotransglycosylase activity
C6993_RS14830	COG3730	PTS system glucitol sorbitol-specific
C6993_RS14835	COG3732	PTS system glucitol sorbitol-specific
C6993_RS14845	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS14850	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS14855	COG1349	DNA-binding transcription factor activity
C6993_RS14880	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
C6993_RS14885	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6993_RS14890	COG1609	Transcriptional regulator
C6993_RS14895	COG1263	PTS System
C6993_RS14895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS14900	COG2723	6-phospho-beta-galactosidase activity
C6993_RS14905	COG5499	transcription regulator containing HTH domain
C6993_RS14910	COG4680	protein conserved in bacteria
C6993_RS14920	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C6993_RS14930	COG3260	NADH ubiquinone oxidoreductase 20
C6993_RS14935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C6993_RS14940	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
C6993_RS14940	COG3261	NADH dehydrogenase
C6993_RS14945	COG0650	Formate hydrogenlyase subunit 4
C6993_RS14950	COG0651	ATP synthesis coupled electron transport
C6993_RS14955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6993_RS14965	COG0375	protein maturation
C6993_RS14970	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C6993_RS14975	COG0298	carbon dioxide binding
C6993_RS14980	COG0409	Hydrogenase expression formation protein
C6993_RS14985	COG0309	Hydrogenase expression formation protein (HypE)
C6993_RS15005	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C6993_RS15010	COG1349	DNA-binding transcription factor activity
C6993_RS15015	COG2084	Dehydrogenase
C6993_RS15020	COG3395	kinase activity
C6993_RS15025	COG0235	Class ii aldolase
C6993_RS15030	COG3622	Belongs to the hyi family
C6993_RS15035	COG2610	gluconate transmembrane transporter activity
C6993_RS15045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C6993_RS15060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6993_RS15065	COG1388	LysM domain
C6993_RS15065	COG4942	peptidase
C6993_RS15120	COG2234	aminopeptidase activity
C6993_RS15125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6993_RS15130	COG1518	maintenance of DNA repeat elements
C6993_RS15145	COG1857	crispr-associated protein
C6993_RS15160	COG1203	CRISPR-associated helicase, Cas3
C6993_RS15190	COG0720	synthase
C6993_RS15195	COG0644	oxidoreductase
C6993_RS15200	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C6993_RS15205	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C6993_RS15210	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C6993_RS15215	COG2086	electron transfer activity
C6993_RS15220	COG0477	Major facilitator Superfamily
C6993_RS15225	COG0277	FAD linked oxidase domain protein
C6993_RS15230	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS15235	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS15240	COG2223	nitrite transmembrane transporter activity
C6993_RS15245	COG1070	Carbohydrate kinase
C6993_RS15250	COG0602	queuosine metabolic process
C6993_RS15260	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C6993_RS15275	COG3956	TIGRFAM MazG family protein
C6993_RS15280	COG2337	Toxic component of a toxin-antitoxin (TA) module
C6993_RS15285	COG2336	PFAM SpoVT AbrB
C6993_RS15290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6993_RS15300	COG3850	Histidine kinase
C6993_RS15300	COG2205	protein histidine kinase activity
C6993_RS15300	COG3437	response regulator, receiver
C6993_RS15300	COG4999	Histidine kinase
C6993_RS15305	COG4948	Mandelate Racemase Muconate Lactonizing
C6993_RS15310	COG4948	Mandelate Racemase Muconate Lactonizing
C6993_RS15315	COG2271	Major facilitator Superfamily
C6993_RS15320	COG0716	FMN binding
C6993_RS15325	COG0564	pseudouridine synthase activity
C6993_RS15330	COG3098	single-species biofilm formation
C6993_RS15345	COG1611	Belongs to the LOG family
C6993_RS15350	COG0814	amino acid
C6993_RS15355	COG1760	l-serine dehydratase
C6993_RS15365	COG1454	alcohol dehydrogenase
C6993_RS15370	COG0235	Class ii aldolase
C6993_RS15375	COG0738	Major facilitator superfamily
C6993_RS15385	COG1070	Carbohydrate kinase
C6993_RS15395	COG1349	DNA-binding transcription factor activity
C6993_RS15405	COG2363	Small membrane protein
C6993_RS15410	COG0583	DNA-binding transcription factor activity
C6993_RS15420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6993_RS15425	COG2166	iron-sulfur cluster assembly
C6993_RS15430	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C6993_RS15435	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C6993_RS15470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C6993_RS15475	COG1263	PTS System
C6993_RS15475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS15480	COG3711	transcriptional antiterminator
C6993_RS15485	COG0860	N-Acetylmuramoyl-L-alanine amidase
C6993_RS15495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C6993_RS15495	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6993_RS15500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6993_RS15505	COG1074	ATP-dependent DNA helicase activity
C6993_RS15510	COG1025	Belongs to the peptidase M16 family
C6993_RS15515	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C6993_RS15520	COG4967	type IV pilus modification protein PilV
C6993_RS15530	COG4795	General secretion pathway protein
C6993_RS15535	COG2165	general secretion pathway protein
C6993_RS15550	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
C6993_RS15565	COG0861	Integral membrane protein TerC family
C6993_RS15575	COG0667	Aldo Keto reductase
C6993_RS15590	COG1609	Transcriptional regulator
C6993_RS15600	COG0583	DNA-binding transcription factor activity
C6993_RS15605	COG1794	racemase activity, acting on amino acids and derivatives
C6993_RS15610	COG2814	Major facilitator Superfamily
C6993_RS15615	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS15625	COG0183	Belongs to the thiolase family
C6993_RS15630	COG0814	amino acid
C6993_RS15635	COG2771	luxR family
C6993_RS15640	COG3710	Transcriptional regulator
C6993_RS15665	COG0457	Tetratricopeptide repeat
C6993_RS15670	COG3710	Transcriptional regulator
C6993_RS15670	COG0457	Tetratricopeptide repeat
C6993_RS15685	COG2197	response regulator
C6993_RS15690	COG2197	response regulator
C6993_RS15775	COG3387	PFAM Glycoside hydrolase 15-related
C6993_RS15790	COG4372	Transposase
C6993_RS15795	COG3436	PFAM IS66 Orf2 family protein
C6993_RS15830	COG4974	Belongs to the 'phage' integrase family
C6993_RS15925	COG4942	peptidase
C6993_RS15935	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6993_RS15940	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C6993_RS15945	COG2080	2 iron, 2 sulfur cluster binding
C6993_RS15950	COG3829	transcription factor binding
C6993_RS15955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6993_RS15960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6993_RS15965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6993_RS15975	COG0549	Belongs to the carbamate kinase family
C6993_RS15980	COG3608	succinylglutamate desuccinylase aspartoacylase
C6993_RS15980	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C6993_RS15985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6993_RS15990	COG2068	MobA-Related Protein
C6993_RS15995	COG0493	'glutamate synthase
C6993_RS15995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6993_RS16000	COG0402	S-adenosylhomocysteine deaminase activity
C6993_RS16005	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C6993_RS16010	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6993_RS16010	COG2080	2 iron, 2 sulfur cluster binding
C6993_RS16015	COG2233	PERMEase
C6993_RS16020	COG0402	S-adenosylhomocysteine deaminase activity
C6993_RS16025	COG2252	PERMEase
C6993_RS16030	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6993_RS16035	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6993_RS16035	COG0493	'glutamate synthase
C6993_RS16045	COG2233	PERMEase
C6993_RS16070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C6993_RS16075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6993_RS16080	COG4974	Belongs to the 'phage' integrase family
C6993_RS16085	COG0716	FMN binding
C6993_RS16095	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C6993_RS16105	COG1272	protein, Hemolysin III
C6993_RS16115	COG2723	6-phospho-beta-galactosidase activity
C6993_RS16120	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS16140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6993_RS16145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6993_RS16150	COG0006	proline dipeptidase activity
C6993_RS16175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6993_RS16195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6993_RS16215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6993_RS16215	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C6993_RS16220	COG1703	isobutyryl-CoA mutase activity
C6993_RS16225	COG1024	Enoyl-CoA hydratase
C6993_RS16230	COG0427	acetyl-CoA hydrolase
C6993_RS16235	COG0583	DNA-binding transcription factor activity
C6993_RS16240	COG2968	Membrane
C6993_RS16250	COG0668	transmembrane transport
C6993_RS16260	COG0191	fructose-bisphosphate aldolase activity
C6993_RS16295	COG1122	ATPase activity
C6993_RS16300	COG1122	ATPase activity
C6993_RS16305	COG1072	(Pantothenic acid kinase))
C6993_RS16315	COG1494	fructose-1,6-bisphosphatase
C6993_RS16320	COG1063	alcohol dehydrogenase
C6993_RS16325	COG2213	PTS system mannitol-specific
C6993_RS16330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS16335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C6993_RS16340	COG0501	Belongs to the peptidase M48B family
C6993_RS16355	COG3716	PTS system mannose fructose sorbose family IID component
C6993_RS16360	COG3715	PTS system
C6993_RS16365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS16365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS16390	COG1166	arginine decarboxylase activity
C6993_RS16415	COG2814	Major facilitator Superfamily
C6993_RS16425	COG2356	endonuclease I
C6993_RS16430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C6993_RS16435	COG0189	ligase activity
C6993_RS16450	COG2805	Type II/IV secretion system protein
C6993_RS16455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C6993_RS16460	COG0762	integral membrane protein
C6993_RS16475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6993_RS16480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6993_RS16485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C6993_RS16500	COG0252	asparaginase activity
C6993_RS16510	COG3171	Protein conserved in bacteria
C6993_RS16525	COG1194	a g-specific adenine glycosylase
C6993_RS16540	COG2211	Major facilitator Superfamily
C6993_RS16545	COG1982	Orn Lys Arg decarboxylase major
C6993_RS16555	COG1811	Na channel or pump
C6993_RS16565	COG0582	viral genome integration into host DNA
C6993_RS16585	COG4771	TonB-dependent receptor
C6993_RS16605	COG2194	sulfuric ester hydrolase activity
C6993_RS16615	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C6993_RS16620	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C6993_RS16625	COG0247	lactate metabolic process
C6993_RS16630	COG0277	FAD linked oxidase domain protein
C6993_RS16635	COG0277	FAD linked oxidase domain protein
C6993_RS16640	COG2186	Transcriptional regulator
C6993_RS16645	COG0456	acetyltransferase
C6993_RS16655	COG0318	PFAM AMP-dependent synthetase and ligase
C6993_RS16665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6993_RS16670	COG0156	8-amino-7-oxononanoate synthase activity
C6993_RS16680	COG0795	lipopolysaccharide-transporting ATPase activity
C6993_RS16685	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C6993_RS16695	COG2244	polysaccharide biosynthetic process
C6993_RS16700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6993_RS16705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6993_RS16710	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6993_RS16715	COG0306	phosphate transporter
C6993_RS16720	COG0754	glutathionylspermidine amidase activity
C6993_RS16725	COG0625	glutathione transferase activity
C6993_RS16735	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS16740	COG0298	carbon dioxide binding
C6993_RS16750	COG1773	rubredoxin
C6993_RS16755	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C6993_RS16760	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
C6993_RS16765	COG5557	Pfam Polysulphide reductase, NrfD
C6993_RS16770	COG0437	4 iron, 4 sulfur cluster binding
C6993_RS16775	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
C6993_RS16795	COG0667	Aldo Keto reductase
C6993_RS16805	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS16810	COG0848	biopolymer transport protein
C6993_RS16815	COG0811	peptide transport
C6993_RS16825	COG0626	cystathionine gamma-synthase activity
C6993_RS16835	COG2207	Transcriptional regulator
C6993_RS16840	COG1979	alcohol dehydrogenase
C6993_RS16845	COG0656	L-ascorbic acid biosynthetic process
C6993_RS16855	COG4238	major outer membrane lipoprotein
C6993_RS16860	COG1032	radical SAM domain protein
C6993_RS16865	COG2132	Multicopper oxidase
C6993_RS16870	COG0204	Acyl-transferase
C6993_RS16875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C6993_RS16885	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C6993_RS16890	COG3111	PFAM Bacterial OB fold (BOF) protein
C6993_RS16895	COG0745	RESPONSE REGULATOR receiver
C6993_RS16900	COG0642	Histidine kinase
C6993_RS16910	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6993_RS16915	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C6993_RS16920	COG0187	DNA topoisomerase II activity
C6993_RS16925	COG3150	esterase
C6993_RS16930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6993_RS16935	COG3151	Protein conserved in bacteria
C6993_RS16940	COG0494	nUDIX hydrolase
C6993_RS16945	COG1538	Outer membrane efflux protein
C6993_RS16960	COG0754	glutathionylspermidine amidase activity
C6993_RS16965	COG3384	dioxygenase
C6993_RS16985	COG2960	long-chain fatty acid transporting porin activity
C6993_RS16990	COG3539	Fimbrial protein
C6993_RS16995	COG3188	usher protein
C6993_RS17000	COG3121	Chaperone
C6993_RS17015	COG1585	Membrane protein implicated in regulation of membrane protease activity
C6993_RS17050	COG3025	triphosphatase activity
C6993_RS17060	COG4991	sh3 domain protein
C6993_RS17075	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6993_RS17085	COG0583	DNA-binding transcription factor activity
C6993_RS17095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C6993_RS17100	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C6993_RS17105	COG0471	metal ion transport
C6993_RS17120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C6993_RS17125	COG0358	DNA primase activity
C6993_RS17135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6993_RS17150	COG2375	cellular response to nickel ion
C6993_RS17160	COG1695	Transcriptional regulator
C6993_RS17165	COG0840	transmembrane signaling receptor activity
C6993_RS17180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6993_RS17190	COG1609	Transcriptional regulator
C6993_RS17195	COG3250	beta-galactosidase activity
C6993_RS17200	COG2731	YhcH YjgK YiaL family protein
C6993_RS17205	COG0531	amino acid
C6993_RS17220	COG1902	pentaerythritol trinitrate reductase activity
C6993_RS17220	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6993_RS17225	COG5499	transcription regulator containing HTH domain
C6993_RS17230	COG4680	protein conserved in bacteria
C6993_RS17240	COG1451	nucleotide metabolic process
C6993_RS17250	COG0673	inositol 2-dehydrogenase activity
C6993_RS17255	COG0861	Integral membrane protein TerC family
C6993_RS17260	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C6993_RS17270	COG2721	sulfolactate sulfo-lyase activity
C6993_RS17280	COG2271	Major facilitator Superfamily
C6993_RS17310	COG2186	Transcriptional regulator
C6993_RS17315	COG0586	Pfam SNARE associated Golgi protein
C6993_RS17325	COG1422	Protein of unknown function (DUF1090)
C6993_RS17330	COG4575	ribosome binding
C6993_RS17335	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
C6993_RS17345	COG2259	Doxx family
C6993_RS17350	COG0435	Glutathione S-transferase
C6993_RS17355	COG3152	Membrane
C6993_RS17360	COG3152	Membrane
C6993_RS17370	COG0583	DNA-binding transcription factor activity
C6993_RS17375	COG1741	Belongs to the pirin family
C6993_RS17390	COG0814	amino acid
C6993_RS17400	COG1760	l-serine dehydratase
C6993_RS17405	COG0251	oxidation-reduction process
C6993_RS17410	COG1882	Formate acetyltransferase
C6993_RS17415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6993_RS17425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6993_RS17435	COG0583	DNA-binding transcription factor activity
C6993_RS17460	COG1929	Belongs to the glycerate kinase type-1 family
C6993_RS17465	COG2084	Dehydrogenase
C6993_RS17475	COG2271	Major facilitator Superfamily
C6993_RS17480	COG2721	sulfolactate sulfo-lyase activity
C6993_RS17485	COG2002	toxin-antitoxin pair type II binding
C6993_RS17495	COG1349	DNA-binding transcription factor activity
C6993_RS17510	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS17520	COG3716	PTS system mannose fructose sorbose family IID component
C6993_RS17525	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS17530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C6993_RS17535	COG2222	sugar isomerase
C6993_RS17545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS17550	COG3715	PTS system
C6993_RS17555	COG3716	PTS system mannose fructose sorbose family IID component
C6993_RS17560	COG0363	glucosamine-6-phosphate deaminase activity
C6993_RS17565	COG3539	Fimbrial protein
C6993_RS17570	COG3121	Chaperone
C6993_RS17575	COG3188	usher protein
C6993_RS17580	COG3539	Fimbrial protein
C6993_RS17585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C6993_RS17605	COG2823	Periplasmic or secreted lipoprotein
C6993_RS17610	COG0701	Predicted permease
C6993_RS17615	COG0702	epimerase
C6993_RS17620	COG0693	protein deglycase activity
C6993_RS17635	COG3153	acetyltransferase
C6993_RS17640	COG3154	lipid carrier protein
C6993_RS17645	COG0826	peptidase U32
C6993_RS17650	COG0826	peptidase U32
C6993_RS17655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6993_RS17660	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS17670	COG0814	amino acid
C6993_RS17675	COG0513	Belongs to the DEAD box helicase family
C6993_RS17715	COG0195	Participates in both transcription termination and antitermination
C6993_RS17735	COG2194	sulfuric ester hydrolase activity
C6993_RS17745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6993_RS17755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6993_RS17760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6993_RS17770	COG1534	Rna-binding protein
C6993_RS17775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6993_RS17780	COG2027	D-alanyl-D-alanine carboxypeptidase
C6993_RS17790	COG0697	spore germination
C6993_RS17805	COG0142	geranyltranstransferase activity
C6993_RS17810	COG3423	Transcriptional regulator
C6993_RS17820	COG5007	Belongs to the BolA IbaG family
C6993_RS17825	COG3113	response to antibiotic
C6993_RS17830	COG2854	intermembrane phospholipid transfer
C6993_RS17835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C6993_RS17840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6993_RS17845	COG1127	ABC transporter
C6993_RS17850	COG0530	calcium, potassium:sodium antiporter activity
C6993_RS17855	COG0517	IMP dehydrogenase activity
C6993_RS17855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C6993_RS17860	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C6993_RS17865	COG3117	lipopolysaccharide transmembrane transporter activity
C6993_RS17870	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C6993_RS17875	COG1137	ATPase activity
C6993_RS17880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C6993_RS17885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C6993_RS17900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS17905	COG0515	serine threonine protein kinase
C6993_RS17915	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C6993_RS17920	COG0784	Response regulator, receiver
C6993_RS17920	COG5002	protein histidine kinase activity
C6993_RS17920	COG2198	Histidine kinase
C6993_RS17925	COG1242	4 iron, 4 sulfur cluster binding
C6993_RS17940	COG0067	glutamate synthase
C6993_RS17940	COG0069	glutamate synthase activity
C6993_RS17940	COG0070	glutamate synthase
C6993_RS17945	COG0493	'glutamate synthase
C6993_RS17955	COG2731	YhcH YjgK YiaL family protein
C6993_RS17990	COG3069	C4-dicarboxylate transmembrane transporter activity
C6993_RS17995	COG2969	positive regulation of protein catabolic process
C6993_RS18000	COG0625	glutathione transferase activity
C6993_RS18030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C6993_RS18035	COG3105	Protein conserved in bacteria
C6993_RS18040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6993_RS18045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6993_RS18065	COG2732	(Barnase) inhibitor
C6993_RS18085	COG0583	DNA-binding transcription factor activity
C6993_RS18090	COG0312	modulator of DNA gyrase
C6993_RS18095	COG3164	Protein of unknown function
C6993_RS18100	COG1530	ribonuclease E activity
C6993_RS18110	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C6993_RS18115	COG1792	Involved in formation and maintenance of cell shape
C6993_RS18120	COG1077	Cell shape determining protein MreB Mrl
C6993_RS18135	COG2200	EAL domain
C6993_RS18135	COG2199	diguanylate cyclase activity
C6993_RS18140	COG0604	alcohol dehydrogenase
C6993_RS18155	COG0511	ligase activity, forming carbon-carbon bonds
C6993_RS18160	COG0439	Biotin carboxylase
C6993_RS18170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6993_RS18175	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6993_RS18180	COG1129	ABC transporter
C6993_RS18185	COG1879	ABC-type sugar transport system periplasmic component
C6993_RS18195	COG1349	DNA-binding transcription factor activity
C6993_RS18200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6993_RS18205	COG3924	membrane
C6993_RS18210	COG4145	pantothenate transmembrane transporter activity
C6993_RS18220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6993_RS18230	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C6993_RS18240	COG1309	transcriptional regulator
C6993_RS18250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6993_RS18255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6993_RS18270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6993_RS18290	COG0765	amino acid transport
C6993_RS18295	COG1126	abc transporter atp-binding protein
C6993_RS18340	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C6993_RS18360	COG0551	DNA topoisomerase type I activity
C6993_RS18370	COG0758	DNA mediated transformation
C6993_RS18390	COG0569	domain protein
C6993_RS18400	COG3036	rescue of stalled ribosome
C6993_RS18405	COG0789	Transcriptional regulator
C6993_RS18445	COG0201	protein transport
C6993_RS18535	COG0089	rRNA binding
C6993_RS18615	COG2964	Protein conserved in bacteria
C6993_RS18620	COG0545	Peptidyl-prolyl cis-trans isomerase
C6993_RS18630	COG1047	Peptidyl-prolyl cis-trans
C6993_RS18635	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
C6993_RS18655	COG0488	(ABC) transporter
C6993_RS18660	COG0429	hydrolase of the alpha beta-hydrolase fold
C6993_RS18670	COG3954	Phosphoribulokinase
C6993_RS18675	COG1765	OsmC-like protein
C6993_RS18685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6993_RS18690	COG1289	transmembrane transporter activity
C6993_RS18695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C6993_RS18700	COG0512	Glutamine amidotransferase of anthranilate synthase
C6993_RS18705	COG2184	nucleotidyltransferase activity
C6993_RS18715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C6993_RS18725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6993_RS18730	COG2146	nitrite reductase [NAD(P)H] activity
C6993_RS18735	COG2116	formate transmembrane transporter activity
C6993_RS18750	COG0531	amino acid
C6993_RS18755	COG2222	sugar isomerase
C6993_RS18765	COG1082	Xylose isomerase domain protein TIM barrel
C6993_RS18775	COG2188	Transcriptional regulator
C6993_RS18780	COG0626	cystathionine gamma-synthase activity
C6993_RS18795	COG1735	metal-dependent hydrolase with the TIM-barrel fold
C6993_RS18800	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C6993_RS18805	COG3457	Alanine racemase
C6993_RS18815	COG2188	Transcriptional regulator
C6993_RS18820	COG0180	Tryptophanyl-tRNA synthetase
C6993_RS18825	COG0546	phosphoglycolate phosphatase activity
C6993_RS18830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6993_RS18835	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C6993_RS18840	COG3266	domain, Protein
C6993_RS18860	COG4796	Type ii and iii secretion system protein
C6993_RS18875	COG3166	PFAM Fimbrial assembly family protein
C6993_RS18880	COG4972	Pilus assembly protein
C6993_RS18885	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C6993_RS18890	COG0494	nUDIX hydrolase
C6993_RS18900	COG1011	Hydrolase
C6993_RS18905	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C6993_RS18915	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
C6993_RS18945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6993_RS18950	COG2183	response to ionizing radiation
C6993_RS18960	COG1918	ferrous iron import across plasma membrane
C6993_RS18965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C6993_RS18980	COG5464	transposase or invertase
C6993_RS19000	COG2610	gluconate transmembrane transporter activity
C6993_RS19005	COG1640	4-alpha-glucanotransferase
C6993_RS19010	COG0058	SHG alpha-glucan phosphorylase activity
C6993_RS19025	COG1690	Belongs to the RtcB family
C6993_RS19030	COG4650	regulator
C6993_RS19035	COG1349	DNA-binding transcription factor activity
C6993_RS19050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C6993_RS19070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C6993_RS19075	COG0058	SHG alpha-glucan phosphorylase activity
C6993_RS19100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C6993_RS19105	COG2095	MarC family integral membrane protein
C6993_RS19110	COG2610	gluconate transmembrane transporter activity
C6993_RS19115	COG3265	gluconokinase activity
C6993_RS19120	COG1609	Transcriptional regulator
C6993_RS19125	COG1741	Belongs to the pirin family
C6993_RS19130	COG0673	inositol 2-dehydrogenase activity
C6993_RS19140	COG1247	-acetyltransferase
C6993_RS19145	COG3157	Type VI secretion system effector, Hcp
C6993_RS19165	COG0405	Gamma-glutamyltransferase
C6993_RS19175	COG0584	glycerophosphoryl diester phosphodiesterase
C6993_RS19180	COG3842	ATPase activity
C6993_RS19190	COG1175	transmembrane transport
C6993_RS19195	COG1653	transport
C6993_RS19200	COG0410	ABC transporter
C6993_RS19205	COG0411	ABC transporter
C6993_RS19210	COG4177	L-phenylalanine transmembrane transporter activity
C6993_RS19215	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6993_RS19220	COG0683	leucine binding
C6993_RS19225	COG0456	acetyltransferase
C6993_RS19230	COG0683	leucine binding
C6993_RS19235	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6993_RS19240	COG2177	Part of the ABC transporter FtsEX involved in
C6993_RS19245	COG2884	Cell division ATP-binding protein ftsE
C6993_RS19250	COG0552	protein localization to endoplasmic reticulum
C6993_RS19255	COG0742	ribosomal rna small subunit methyltransferase
C6993_RS19260	COG3776	membrane
C6993_RS19270	COG3714	YhhN family
C6993_RS19285	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C6993_RS19300	COG0628	permease
C6993_RS19305	COG2091	lysine biosynthetic process via aminoadipic acid
C6993_RS19310	COG0747	negative chemotaxis
C6993_RS19315	COG0601	transmembrane transport
C6993_RS19320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6993_RS19325	COG0444	Belongs to the ABC transporter superfamily
C6993_RS19340	COG3209	COG3209 Rhs family protein
C6993_RS19350	COG1413	lyase activity
C6993_RS19360	COG0842	Transport permease protein
C6993_RS19365	COG0842	Transport permease protein
C6993_RS19365	COG1129	ABC transporter
C6993_RS19370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6993_RS19395	COG2081	HI0933 family
C6993_RS19400	COG0306	phosphate transporter
C6993_RS19410	COG0589	response to stress
C6993_RS19420	COG3104	oligopeptide transport
C6993_RS19430	COG0339	signal peptide processing
C6993_RS19435	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C6993_RS19440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6993_RS19455	COG0640	Transcriptional regulator
C6993_RS19465	COG1393	Belongs to the ArsC family
C6993_RS19485	COG3065	identical protein binding
C6993_RS19500	COG1285	pathogenesis
C6993_RS19515	COG3247	response to pH
C6993_RS19520	COG2771	luxR family
C6993_RS19530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6993_RS19535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6993_RS19545	COG2207	Transcriptional regulator
C6993_RS19555	COG0076	glutamate decarboxylase activity
C6993_RS19560	COG1858	cytochrome C peroxidase
C6993_RS19570	COG2197	response regulator
C6993_RS19575	COG0583	DNA-binding transcription factor activity
C6993_RS19580	COG1295	ribonuclease BN
C6993_RS19585	COG0477	Major facilitator Superfamily
C6993_RS19590	COG2982	Protein involved in outer membrane biogenesis
C6993_RS19595	COG2200	EAL domain
C6993_RS19610	COG0612	Peptidase, M16
C6993_RS19630	COG2199	diguanylate cyclase activity
C6993_RS19630	COG2200	EAL domain
C6993_RS19635	COG0457	Tetratricopeptide repeat
C6993_RS19635	COG3118	belongs to the thioredoxin family
C6993_RS19640	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C6993_RS19645	COG1215	transferase activity, transferring glycosyl groups
C6993_RS19650	COG1215	transferase activity, transferring glycosyl groups
C6993_RS19675	COG2194	sulfuric ester hydrolase activity
C6993_RS19720	COG0814	amino acid
C6993_RS19725	COG4608	Belongs to the ABC transporter superfamily
C6993_RS19730	COG0444	Belongs to the ABC transporter superfamily
C6993_RS19735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C6993_RS19740	COG0601	transmembrane transport
C6993_RS19750	COG0747	negative chemotaxis
C6993_RS19760	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS19780	COG2194	sulfuric ester hydrolase activity
C6993_RS19810	COG2223	nitrite transmembrane transporter activity
C6993_RS19820	COG5571	outer membrane autotransporter
C6993_RS19825	COG2818	Glycosylase
C6993_RS19830	COG0456	acetyltransferase
C6993_RS19835	COG0243	molybdopterin cofactor binding
C6993_RS19840	COG2885	chlorophyll binding
C6993_RS19855	COG2944	sequence-specific DNA binding
C6993_RS19860	COG1278	Cold shock
C6993_RS19885	COG3274	enterobacterial common antigen metabolic process
C6993_RS19890	COG4682	membrane
C6993_RS19895	COG4682	membrane
C6993_RS19900	COG1070	Carbohydrate kinase
C6993_RS19910	COG4213	ABC transporter substrate-binding protein
C6993_RS19915	COG1129	ABC transporter
C6993_RS19920	COG4214	carbohydrate transport
C6993_RS19925	COG2207	Transcriptional regulator
C6993_RS19925	COG1609	Transcriptional regulator
C6993_RS19930	COG2992	FlgJ-related protein
C6993_RS19935	COG0366	Alpha amylase catalytic
C6993_RS19940	COG3977	Valine--pyruvate aminotransferase
C6993_RS19945	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6993_RS19950	COG1414	Transcriptional regulator
C6993_RS19960	COG2731	YhcH YjgK YiaL family protein
C6993_RS19965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C6993_RS19970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6993_RS19975	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6993_RS19980	COG1070	Carbohydrate kinase
C6993_RS19985	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C6993_RS19990	COG3623	hexulose-6-phosphate isomerase
C6993_RS19995	COG0235	Class ii aldolase
C6993_RS20005	COG3713	MltA-interacting MipA family protein
C6993_RS20010	COG0583	DNA-binding transcription factor activity
C6993_RS20015	COG1566	PFAM secretion protein HlyD family protein
C6993_RS20030	COG1012	belongs to the aldehyde dehydrogenase family
C6993_RS20035	COG1454	alcohol dehydrogenase
C6993_RS20040	COG3276	selenocysteine insertion sequence binding
C6993_RS20050	COG0625	glutathione transferase activity
C6993_RS20055	COG3209	COG3209 Rhs family protein
C6993_RS20060	COG1413	lyase activity
C6993_RS20065	COG3209	COG3209 Rhs family protein
C6993_RS20070	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C6993_RS20100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS20100	COG2213	PTS system mannitol-specific
C6993_RS20110	COG3722	fumarate hydratase activity
C6993_RS20135	COG5295	Hep Hag repeat protein
C6993_RS20145	COG1620	l-lactate permease
C6993_RS20150	COG2186	Transcriptional regulator
C6993_RS20160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C6993_RS20165	COG1045	serine acetyltransferase
C6993_RS20180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C6993_RS20185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6993_RS20200	COG4942	peptidase
C6993_RS20205	COG2861	carbohydrate metabolic process
C6993_RS20210	COG1216	Glycosyl transferase, family 2
C6993_RS20220	COG0156	8-amino-7-oxononanoate synthase activity
C6993_RS20235	COG0859	PFAM glycosyl transferase family 9
C6993_RS20240	COG0859	PFAM glycosyl transferase family 9
C6993_RS20260	COG3642	lipopolysaccharide core region biosynthetic process
C6993_RS20270	COG0515	serine threonine protein kinase
C6993_RS20275	COG0438	transferase activity, transferring glycosyl groups
C6993_RS20280	COG0859	PFAM glycosyl transferase family 9
C6993_RS20285	COG1519	Transferase
C6993_RS20315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C6993_RS20345	COG1561	YicC-like family, N-terminal region
C6993_RS20350	COG3645	SOS response
C6993_RS20355	COG2860	membrane
C6993_RS20365	COG0194	GDP metabolic process
C6993_RS20375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6993_RS20380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6993_RS20385	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C6993_RS20395	COG0786	glutamate:sodium symporter activity
C6993_RS20400	COG2233	PERMEase
C6993_RS20405	COG2982	Protein involved in outer membrane biogenesis
C6993_RS20410	COG1501	Belongs to the glycosyl hydrolase 31 family
C6993_RS20415	COG2211	Major facilitator Superfamily
C6993_RS20425	COG0582	viral genome integration into host DNA
C6993_RS20480	COG4372	Transposase
C6993_RS20485	COG3436	PFAM IS66 Orf2 family protein
C6993_RS20525	COG2814	Major facilitator Superfamily
C6993_RS20530	COG0697	spore germination
C6993_RS20535	COG1464	Belongs to the NlpA lipoprotein family
C6993_RS20565	COG2252	PERMEase
C6993_RS20575	COG2271	Major facilitator Superfamily
C6993_RS20580	COG2271	Major facilitator Superfamily
C6993_RS20585	COG3851	Histidine kinase
C6993_RS20590	COG2197	response regulator
C6993_RS20595	COG0440	acetolactate synthase activity
C6993_RS20600	COG0028	Belongs to the TPP enzyme family
C6993_RS20635	COG2814	Major facilitator Superfamily
C6993_RS20640	COG0641	radical SAM
C6993_RS20650	COG2149	membrane
C6993_RS20660	COG3119	arylsulfatase activity
C6993_RS20665	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6993_RS20670	COG2207	Transcriptional regulator
C6993_RS20685	COG2188	Transcriptional regulator
C6993_RS20705	COG5645	(Lipo)protein
C6993_RS20710	COG0823	Involved in the tonB-independent uptake of proteins
C6993_RS20720	COG2271	Major facilitator Superfamily
C6993_RS20730	COG0800	Aldolase
C6993_RS20735	COG3734	2-keto-3-deoxy-galactonokinase
C6993_RS20740	COG2186	Transcriptional regulator
C6993_RS20750	COG0561	phosphatase activity
C6993_RS20755	COG3753	Protein conserved in bacteria
C6993_RS20760	COG0187	DNA topoisomerase II activity
C6993_RS20770	COG0592	DNA-directed DNA polymerase activity
C6993_RS20820	COG0814	amino acid
C6993_RS20835	COG2091	lysine biosynthetic process via aminoadipic acid
C6993_RS20840	COG0431	NADPH-dependent FMN reductase
C6993_RS20845	COG2252	PERMEase
C6993_RS20850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C6993_RS20860	COG3196	Protein conserved in bacteria
C6993_RS20865	COG0363	glucosamine-6-phosphate deaminase activity
C6993_RS20870	COG2382	esterase
C6993_RS20880	COG2723	6-phospho-beta-galactosidase activity
C6993_RS20885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS20885	COG2190	(PTS) system
C6993_RS20885	COG1263	PTS System
C6993_RS20890	COG3711	transcriptional antiterminator
C6993_RS20895	COG0704	Plays a role in the regulation of phosphate uptake
C6993_RS20900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6993_RS20905	COG0581	inorganic phosphate transmembrane transporter activity
C6993_RS20910	COG0573	inorganic phosphate transmembrane transporter activity
C6993_RS20915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C6993_RS20925	COG3188	usher protein
C6993_RS20940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6993_RS20995	COG3312	ion transport
C6993_RS21010	COG0716	FMN binding
C6993_RS21015	COG1522	sequence-specific DNA binding
C6993_RS21045	COG1129	ABC transporter
C6993_RS21050	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6993_RS21055	COG1879	ABC-type sugar transport system periplasmic component
C6993_RS21060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6993_RS21065	COG1609	Transcriptional regulator
C6993_RS21070	COG0477	Major facilitator Superfamily
C6993_RS21075	COG2186	Transcriptional regulator
C6993_RS21115	COG3085	chromosome segregation
C6993_RS21120	COG0606	chelatase, subunit chli
C6993_RS21145	COG3978	acetolactate synthase activity
C6993_RS21150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C6993_RS21160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6993_RS21165	COG0583	DNA-binding transcription factor activity
C6993_RS21175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6993_RS21180	COG3692	DNA binding
C6993_RS21185	COG0210	DNA helicase
C6993_RS21205	COG3118	belongs to the thioredoxin family
C6993_RS21215	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C6993_RS21225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6993_RS21230	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C6993_RS21235	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C6993_RS21240	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C6993_RS21245	COG1088	dTDP-glucose 4,6-dehydratase activity
C6993_RS21250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C6993_RS21255	COG0456	acetyltransferase
C6993_RS21260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6993_RS21265	COG2244	polysaccharide biosynthetic process
C6993_RS21285	COG1113	amino acid transport
C6993_RS21310	COG0641	radical SAM
C6993_RS21315	COG3071	HemY protein
C6993_RS21320	COG2959	enzyme of heme biosynthesis
C6993_RS21325	COG1587	Uroporphyrinogen-III synthase
C6993_RS21340	COG3072	Adenylate cyclase
C6993_RS21365	COG5567	small periplasmic lipoprotein
C6993_RS21375	COG3159	Protein conserved in bacteria
C6993_RS21385	COG1011	Hydrolase
C6993_RS21390	COG0210	DNA helicase
C6993_RS21395	COG3698	Phosphodiester glycosidase
C6993_RS21400	COG0598	Magnesium transport protein CorA
C6993_RS21430	COG2962	Rard protein
C6993_RS21435	COG2050	protein possibly involved in aromatic compounds catabolism
C6993_RS21440	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
C6993_RS21445	COG0514	ATP-dependent DNA helicase (RecQ)
C6993_RS21450	COG1280	lysine exporter protein (LysE YggA)
C6993_RS21455	COG1280	lysine exporter protein (LysE YggA)
C6993_RS21460	COG2267	carboxylic ester hydrolase activity
C6993_RS21465	COG0561	phosphatase activity
C6993_RS21470	COG0697	spore germination
C6993_RS21475	COG0583	DNA-binding transcription factor activity
C6993_RS21485	COG0412	Dienelactone hydrolase
C6993_RS21490	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
C6993_RS21500	COG1322	Protein conserved in bacteria
C6993_RS21510	COG3165	ubiquinone biosynthetic process from chorismate
C6993_RS21520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6993_RS21525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6993_RS21530	COG0805	protein transport
C6993_RS21540	COG0250	Participates in transcription elongation, termination and antitermination
C6993_RS21545	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C6993_RS21550	COG0543	2 iron, 2 sulfur cluster binding
C6993_RS21570	COG1739	Uncharacterized protein family UPF0029
C6993_RS21575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6993_RS21580	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
C6993_RS21610	COG1763	Mo-molybdopterin cofactor biosynthetic process
C6993_RS21615	COG0746	molybdenum cofactor guanylyltransferase activity
C6993_RS21620	COG3084	Protein conserved in bacteria
C6993_RS21625	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C6993_RS21630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6993_RS21635	COG5339	Protein conserved in bacteria
C6993_RS21640	COG0204	Acyl-transferase
C6993_RS21650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6993_RS21650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C6993_RS21665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6993_RS21675	COG2204	response regulator
C6993_RS21680	COG3852	Histidine kinase
C6993_RS21690	COG0174	glutamine synthetase
C6993_RS21700	COG1217	gtp-binding protein TYPA
C6993_RS21705	COG2188	Transcriptional regulator
C6993_RS21710	COG1082	Xylose isomerase domain protein TIM barrel
C6993_RS21715	COG2271	Major facilitator Superfamily
C6993_RS21720	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C6993_RS21725	COG2211	Major facilitator Superfamily
C6993_RS21730	COG1501	Belongs to the glycosyl hydrolase 31 family
C6993_RS21735	COG2017	converts alpha-aldose to the beta-anomer
C6993_RS21740	COG2942	2-epimerase
C6993_RS21745	COG3684	Belongs to the aldolase LacD family
C6993_RS21750	COG2084	Dehydrogenase
C6993_RS21755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6993_RS21760	COG1349	DNA-binding transcription factor activity
C6993_RS21765	COG1011	Hydrolase
C6993_RS21780	COG0456	acetyltransferase
C6993_RS21790	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C6993_RS21805	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C6993_RS21810	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C6993_RS21815	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS21830	COG2864	formate dehydrogenase
C6993_RS21835	COG0437	4 iron, 4 sulfur cluster binding
C6993_RS21860	COG3711	transcriptional antiterminator
C6993_RS21860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS21865	COG1363	Peptidase, m42
C6993_RS21870	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS21870	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS21875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS21885	COG1454	alcohol dehydrogenase
C6993_RS21920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C6993_RS21935	COG2258	MOSC domain
C6993_RS21940	COG2205	protein histidine kinase activity
C6993_RS21945	COG0745	RESPONSE REGULATOR receiver
C6993_RS21950	COG3678	ATP-independent chaperone mediated protein folding
C6993_RS21965	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C6993_RS21985	COG3152	Membrane
C6993_RS21990	COG3691	Protein conserved in bacteria
C6993_RS21995	COG0589	response to stress
C6993_RS22005	COG1494	fructose-1,6-bisphosphatase
C6993_RS22015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C6993_RS22030	COG1575	Belongs to the MenA family. Type 1 subfamily
C6993_RS22045	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C6993_RS22050	COG1609	Transcriptional regulator
C6993_RS22055	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C6993_RS22065	COG3209	COG3209 Rhs family protein
C6993_RS22085	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C6993_RS22095	COG0626	cystathionine gamma-synthase activity
C6993_RS22100	COG0527	aspartate kinase activity
C6993_RS22100	COG0460	homoserine dehydrogenase
C6993_RS22105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C6993_RS22115	COG0697	spore germination
C6993_RS22120	COG3738	Protein conserved in bacteria
C6993_RS22125	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS22135	COG0371	Dehydrogenase
C6993_RS22140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6993_RS22150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS22155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS22160	COG1882	Formate acetyltransferase
C6993_RS22165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C6993_RS22170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS22175	COG2207	Transcriptional regulator
C6993_RS22180	COG2194	sulfuric ester hydrolase activity
C6993_RS22195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6993_RS22210	COG0583	DNA-binding transcription factor activity
C6993_RS22275	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C6993_RS22275	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C6993_RS22320	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6993_RS22325	COG0250	Participates in transcription elongation, termination and antitermination
C6993_RS22370	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C6993_RS22380	COG2104	thiamine diphosphate biosynthetic process
C6993_RS22385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C6993_RS22420	COG3068	Protein conserved in bacteria
C6993_RS22435	COG3678	ATP-independent chaperone mediated protein folding
C6993_RS22445	COG4191	Histidine kinase
C6993_RS22450	COG2204	response regulator
C6993_RS22455	COG0151	Belongs to the GarS family
C6993_RS22490	COG0456	acetyltransferase
C6993_RS22500	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C6993_RS22505	COG2224	Isocitrate lyase
C6993_RS22520	COG1414	Transcriptional regulator
C6993_RS22525	COG1410	methionine synthase
C6993_RS22525	COG0646	methionine synthase
C6993_RS22530	COG1283	sodium-dependent phosphate transmembrane transporter activity
C6993_RS22590	COG3541	Predicted nucleotidyltransferase
C6993_RS22595	COG0542	response to heat
C6993_RS22600	COG0527	aspartate kinase activity
C6993_RS22635	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6993_RS22650	COG0477	Major facilitator Superfamily
C6993_RS22650	COG2814	Major facilitator Superfamily
C6993_RS22655	COG3833	ABC-type maltose transport systems, permease component
C6993_RS22660	COG1175	transmembrane transport
C6993_RS22665	COG2182	Extracellular solute-binding protein
C6993_RS22675	COG3842	ATPase activity
C6993_RS22695	COG1357	PFAM Pentapeptide repeats (8 copies)
C6993_RS22720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C6993_RS22730	COG0534	Mate efflux family protein
C6993_RS22735	COG3237	CsbD-like
C6993_RS22740	COG0735	belongs to the Fur family
C6993_RS22755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C6993_RS22765	COG0604	alcohol dehydrogenase
C6993_RS22770	COG0305	Participates in initiation and elongation during chromosome replication
C6993_RS22775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6993_RS22780	COG1448	Aminotransferase
C6993_RS22790	COG3700	Belongs to the class B bacterial acid phosphatase family
C6993_RS22795	COG0432	Pfam Uncharacterised protein family UPF0047
C6993_RS22800	COG2315	Protein conserved in bacteria
C6993_RS22805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C6993_RS22815	COG0629	single-stranded DNA binding
C6993_RS22830	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C6993_RS22835	COG2207	Transcriptional regulator
C6993_RS22840	COG0789	Transcriptional regulator
C6993_RS22860	COG2252	PERMEase
C6993_RS22865	COG0025	NhaP-type Na H and K H
C6993_RS22880	COG3162	membrane
C6993_RS22885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6993_RS22900	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
C6993_RS22905	COG0437	4 iron, 4 sulfur cluster binding
C6993_RS22910	COG3301	Polysulphide reductase, NrfD
C6993_RS22915	COG1138	Cytochrome C-type biogenesis protein
C6993_RS22920	COG3088	subunit of a heme lyase
C6993_RS22925	COG4235	cytochrome complex assembly
C6993_RS22935	COG1301	dicarboxylic acid transport
C6993_RS22940	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C6993_RS22955	COG1289	transmembrane transporter activity
C6993_RS22960	COG1566	PFAM secretion protein HlyD family protein
C6993_RS22970	COG2015	COG2015, Alkyl sulfatase and related hydrolases
C6993_RS22975	COG0698	ribose 5-phosphate isomerase
C6993_RS22985	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6993_RS22990	COG0456	acetyltransferase
C6993_RS22995	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C6993_RS23000	COG3454	Phosphonate metabolism
C6993_RS23005	COG4778	phosphonate C-P lyase system protein PhnL
C6993_RS23010	COG4107	phosphonate C-P lyase system protein PhnK
C6993_RS23015	COG3627	carbon phosphorus lyase activity
C6993_RS23020	COG3626	phosphonate metabolism
C6993_RS23025	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
C6993_RS23030	COG3624	Phosphonate C-P lyase system protein PhnG
C6993_RS23035	COG2188	Transcriptional regulator
C6993_RS23040	COG3639	organic phosphonate transmembrane transporter activity
C6993_RS23045	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C6993_RS23055	COG2764	glyoxalase bleomycin resistance protein dioxygenase
C6993_RS23060	COG2824	Alkylphosphonate utilization operon protein PhnA
C6993_RS23070	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C6993_RS23080	COG0477	Major facilitator Superfamily
C6993_RS23090	COG0642	Histidine kinase
C6993_RS23095	COG0745	RESPONSE REGULATOR receiver
C6993_RS23100	COG2194	sulfuric ester hydrolase activity
C6993_RS23105	COG0531	amino acid
C6993_RS23110	COG2207	Transcriptional regulator
C6993_RS23115	COG1982	Orn Lys Arg decarboxylase major
C6993_RS23120	COG2169	Transcriptional regulator
C6993_RS23130	COG1486	melibiose metabolic process
C6993_RS23135	COG2211	Major facilitator Superfamily
C6993_RS23145	COG3647	Membrane
C6993_RS23150	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C6993_RS23150	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
C6993_RS23155	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C6993_RS23165	COG4565	transcriptional regulatory protein
C6993_RS23170	COG3290	protein histidine kinase activity
C6993_RS23175	COG3592	Divergent 4Fe-4S mono-cluster
C6993_RS23180	COG2388	GCN5-related N-acetyl-transferase
C6993_RS23200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6993_RS23205	COG3104	oligopeptide transport
C6993_RS23210	COG1982	Orn Lys Arg decarboxylase major
C6993_RS23215	COG0531	amino acid
C6993_RS23225	COG3710	Transcriptional regulator
C6993_RS23515	COG4372	Transposase
C6993_RS23520	COG0582	viral genome integration into host DNA
C6993_RS23530	COG1309	transcriptional regulator
C6993_RS23545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
C6993_RS23550	COG1027	Aspartate ammonia-lyase
C6993_RS23555	COG3030	protein affecting phage T7 exclusion by the F plasmid
C6993_RS23560	COG0531	amino acid
C6993_RS23585	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS23590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C6993_RS23600	COG1609	Transcriptional regulator
C6993_RS23605	COG1263	PTS System
C6993_RS23605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS23610	COG0366	Alpha amylase catalytic
C6993_RS23615	COG1328	CTP reductase activity
C6993_RS23620	COG0602	queuosine metabolic process
C6993_RS23640	COG3436	PFAM IS66 Orf2 family protein
C6993_RS23645	COG4372	Transposase
C6993_RS23655	COG0312	modulator of DNA gyrase
C6993_RS23665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6993_RS23675	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6993_RS23680	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6993_RS23685	COG1129	ABC transporter
C6993_RS23690	COG1879	ABC-type sugar transport system periplasmic component
C6993_RS23695	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C6993_RS23700	COG2337	Toxic component of a toxin-antitoxin (TA) module
C6993_RS23705	COG2336	PFAM SpoVT AbrB
C6993_RS23710	COG2105	PFAM AIG2 family protein
C6993_RS23715	COG2911	Protein conserved in bacteria
C6993_RS23720	COG0729	surface antigen
C6993_RS23735	COG1253	flavin adenine dinucleotide binding
C6993_RS23745	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
C6993_RS23750	COG1218	3'(2'),5'-bisphosphate nucleotidase
C6993_RS23755	COG0737	Belongs to the 5'-nucleotidase family
C6993_RS23760	COG1733	regulation of RNA biosynthetic process
C6993_RS23765	COG0702	epimerase
C6993_RS23770	COG0697	spore germination
C6993_RS23790	COG1113	amino acid transport
C6993_RS23795	COG0545	Peptidyl-prolyl cis-trans isomerase
C6993_RS23805	COG3061	Opacity-associated protein A
C6993_RS23815	COG0675	Transposase, IS605 OrfB family
C6993_RS23840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6993_RS23885	COG3037	sugar-specific permease SgaT UlaA
C6993_RS23900	COG1073	alpha beta
C6993_RS23905	COG3650	response to hydrogen peroxide
C6993_RS23915	COG1960	acyl-CoA dehydrogenase activity
C6993_RS23920	COG0754	glutathionylspermidine amidase activity
C6993_RS23925	COG5463	Belongs to the UPF0441 family
C6993_RS23930	COG3766	membrane
C6993_RS23940	COG1842	Phage shock protein A
C6993_RS23945	COG3789	protein conserved in bacteria
C6993_RS23955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6993_RS23960	COG0557	exoribonuclease II activity
C6993_RS23975	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
C6993_RS23980	COG0330	HflC and HflK could
C6993_RS23985	COG0330	HflC and HflK could
C6993_RS23990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6993_RS24010	COG0860	N-Acetylmuramoyl-L-alanine amidase
C6993_RS24015	COG0802	atpase or kinase
C6993_RS24020	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6993_RS24020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6993_RS24065	COG3264	Mechanosensitive ion channel
C6993_RS24065	COG1511	domain protein
C6993_RS24080	COG0531	amino acid
C6993_RS24090	COG1053	succinate dehydrogenase
C6993_RS24095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C6993_RS24110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6993_RS24115	COG3040	lipid binding
C6993_RS24120	COG2076	Multidrug Resistance protein
C6993_RS24125	COG5510	response to toxic substance
C6993_RS24130	COG5510	response to toxic substance
C6993_RS24140	COG1509	lysine 2,3-aminomutase activity
C6993_RS24150	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS24160	COG0251	oxidation-reduction process
C6993_RS24185	COG0251	oxidation-reduction process
C6993_RS24190	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS24195	COG1309	transcriptional regulator
C6993_RS24200	COG2731	YhcH YjgK YiaL family protein
C6993_RS24220	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
C6993_RS24225	COG0456	acetyltransferase
C6993_RS24240	COG2927	DNA polymerase III (CHI subunit)
C6993_RS24250	COG0795	lipopolysaccharide-transporting ATPase activity
C6993_RS24255	COG0795	lipopolysaccharide-transporting ATPase activity
C6993_RS24260	COG0433	COG0433 Predicted ATPase
C6993_RS24265	COG1064	alcohol dehydrogenase
C6993_RS24275	COG0582	viral genome integration into host DNA
C6993_RS24300	COG3436	PFAM IS66 Orf2 family protein
C6993_RS24305	COG4372	Transposase
C6993_RS24370	COG2085	NADP oxidoreductase coenzyme F420-dependent
C6993_RS24375	COG1120	ATPase activity
C6993_RS24380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6993_RS24385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6993_RS24390	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C6993_RS24395	COG4772	TonB-dependent receptor
C6993_RS24400	COG3712	iron ion homeostasis
C6993_RS24405	COG1595	DNA-templated transcription, initiation
C6993_RS24450	COG4372	Transposase
C6993_RS24455	COG3436	PFAM IS66 Orf2 family protein
C6993_RS24485	COG4372	Transposase
C6993_RS24490	COG3436	PFAM IS66 Orf2 family protein
C6993_RS24530	COG3436	PFAM IS66 Orf2 family protein
C6993_RS24535	COG4372	Transposase
C6993_RS24555	COG4983	Phage plasmid primase, P4 family domain protein
C6993_RS24570	COG3468	outer membrane autotransporter barrel domain protein
C6993_RS24575	COG2020	methyltransferase activity
C6993_RS24605	COG2003	Belongs to the UPF0758 family
C6993_RS24665	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
C6993_RS24670	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C6993_RS24690	COG0582	viral genome integration into host DNA
C6993_RS24695	COG4974	Belongs to the 'phage' integrase family
C6993_RS24710	COG3539	Fimbrial protein
C6993_RS24715	COG3121	Chaperone
C6993_RS24720	COG3188	usher protein
C6993_RS24725	COG3539	Fimbrial protein
C6993_RS24730	COG3539	Fimbrial protein
C6993_RS24735	COG3539	Fimbrial protein
C6993_RS24755	COG0246	Mannitol dehydrogenase
C6993_RS24765	COG2186	Transcriptional regulator
C6993_RS24790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C6993_RS24795	COG0700	Nucleoside recognition
C6993_RS24800	COG3366	ferrous iron transmembrane transporter activity
C6993_RS24815	COG0477	Major facilitator Superfamily
C6993_RS24830	COG1924	4 iron, 4 sulfur cluster binding
C6993_RS24835	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
C6993_RS24840	COG2733	membrane
C6993_RS24845	COG2814	Major facilitator Superfamily
C6993_RS24855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6993_RS24860	COG5457	Domain of unknown function (DUF1127)
C6993_RS24875	COG0732	type I restriction modification DNA specificity domain
C6993_RS24900	COG0523	cobalamin synthesis protein
C6993_RS24905	COG2879	small protein
C6993_RS24910	COG1966	Carbon starvation protein
C6993_RS24920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6993_RS24925	COG2368	4-hydroxyphenylacetate
C6993_RS24945	COG3971	2-oxopent-4-enoate hydratase activity
C6993_RS24955	COG3384	dioxygenase
C6993_RS24960	COG1012	belongs to the aldehyde dehydrogenase family
C6993_RS24965	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6993_RS24970	COG1846	Transcriptional regulator
C6993_RS24975	COG0840	transmembrane signaling receptor activity
C6993_RS24980	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6993_RS24990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6993_RS24995	COG0025	NhaP-type Na H and K H
C6993_RS25000	COG1802	Transcriptional regulator
C6993_RS25005	COG1063	alcohol dehydrogenase
C6993_RS25020	COG1484	DNA-dependent DNA replication
C6993_RS25035	COG2966	Psort location CytoplasmicMembrane, score
C6993_RS25040	COG2197	response regulator
C6993_RS25045	COG2197	response regulator
C6993_RS25050	COG4114	ferric iron reductase
C6993_RS25080	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
C6993_RS25085	COG0456	acetyltransferase
C6993_RS25090	COG1011	Hydrolase
C6993_RS25100	COG2823	Periplasmic or secreted lipoprotein
C6993_RS25110	COG4667	esterase of the alpha-beta hydrolase superfamily
C6993_RS25115	COG0084	hydrolase, TatD family'
C6993_RS25130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
C6993_RS25135	COG1328	CTP reductase activity
C6993_RS25170	COG3726	membrane protein affecting hemolysin expression
C6993_RS25175	COG0560	Phosphoserine phosphatase
C6993_RS25180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C6993_RS25185	COG3172	ATPase kinase involved in NAD metabolism
C6993_RS25185	COG1056	cytidyltransferase-related domain
C6993_RS25190	COG0488	(ABC) transporter
C6993_RS25200	COG0741	lytic transglycosylase activity
C6993_RS25220	COG2207	Transcriptional regulator
C6993_RS25220	COG3708	Transcriptional regulator
C6993_RS25225	COG3045	CreA protein
C6993_RS25230	COG0745	RESPONSE REGULATOR receiver
C6993_RS25235	COG2205	protein histidine kinase activity
C6993_RS25240	COG4452	Inner membrane protein CreD
C6993_RS25245	COG0745	RESPONSE REGULATOR receiver
C6993_RS25255	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C6993_RS25275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C6993_RS25290	COG1115	amino acid carrier protein
C6993_RS25300	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6993_RS25305	COG1584	GPR1 FUN34 yaaH family protein
C6993_RS25310	COG4735	regulation of single-species biofilm formation
C6993_RS25340	COG0583	DNA-binding transcription factor activity
C6993_RS25370	COG0196	riboflavin kinase activity
C6993_RS25385	COG1047	Peptidyl-prolyl cis-trans
C6993_RS25410	COG0505	Belongs to the CarA family
C6993_RS25415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C6993_RS25470	COG0644	oxidoreductase
C6993_RS25475	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
C6993_RS25480	COG2271	Major facilitator Superfamily
C6993_RS25495	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C6993_RS25535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6993_RS25540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C6993_RS25545	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C6993_RS25550	COG0564	pseudouridine synthase activity
C6993_RS25560	COG0417	DNA replication proofreading
C6993_RS25565	COG0235	Class ii aldolase
C6993_RS25585	COG4977	sequence-specific DNA binding
C6993_RS25590	COG0586	Pfam SNARE associated Golgi protein
C6993_RS25605	COG4143	(ABC) transporter
C6993_RS25620	COG2814	Major facilitator Superfamily
C6993_RS25635	COG0473	3-isopropylmalate dehydrogenase activity
C6993_RS25650	COG0583	DNA-binding transcription factor activity
C6993_RS25655	COG0028	Belongs to the TPP enzyme family
C6993_RS25660	COG0440	acetolactate synthase activity
C6993_RS25670	COG1609	Transcriptional regulator
C6993_RS25695	COG3116	cell division
C6993_RS25700	COG0768	penicillin binding
C6993_RS25705	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6993_RS25710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6993_RS25725	COG0772	Belongs to the SEDS family
C6993_RS25740	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6993_RS25745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C6993_RS25750	COG0849	cell division
C6993_RS25755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C6993_RS25775	COG0494	nUDIX hydrolase
C6993_RS25785	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS25800	COG0237	dephospho-CoA kinase activity
C6993_RS25810	COG1459	type II secretion system
C6993_RS25815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C6993_RS25820	COG4969	Belongs to the N-Me-Phe pilin family
C6993_RS25830	COG0157	Belongs to the NadC ModD family
C6993_RS25835	COG3023	N-Acetylmuramoyl-L-alanine amidase
C6993_RS25840	COG3725	Membrane protein required for beta-lactamase induction
C6993_RS25845	COG1113	amino acid transport
C6993_RS25850	COG2186	Transcriptional regulator
C6993_RS25860	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C6993_RS25865	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6993_RS25870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6993_RS25875	COG3064	Membrane
C6993_RS25885	COG1049	propionate catabolic process, 2-methylcitrate cycle
C6993_RS25910	COG2132	Multicopper oxidase
C6993_RS25915	COG4993	Dehydrogenase
C6993_RS25920	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C6993_RS25925	COG0288	reversible hydration of carbon dioxide
C6993_RS25930	COG1131	(ABC) transporter
C6993_RS25935	COG0842	Transport permease protein
C6993_RS25940	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS25945	COG0726	polysaccharide deacetylase
C6993_RS25960	COG5464	transposase or invertase
C6993_RS25980	COG3539	Fimbrial protein
C6993_RS25985	COG3539	Fimbrial protein
C6993_RS25990	COG3539	Fimbrial protein
C6993_RS25995	COG3188	usher protein
C6993_RS26000	COG3121	Chaperone
C6993_RS26005	COG3539	Fimbrial protein
C6993_RS26010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C6993_RS26015	COG0617	tRNA 3'-terminal CCA addition
C6993_RS26025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C6993_RS26035	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C6993_RS26040	COG1643	Atp-dependent helicase
C6993_RS26050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6993_RS26055	COG4774	siderophore transport
C6993_RS26060	COG1120	ATPase activity
C6993_RS26065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C6993_RS26070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6993_RS26090	COG2860	membrane
C6993_RS26095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C6993_RS26115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6993_RS26120	COG3835	regulator
C6993_RS26130	COG1408	metallophosphoesterase
C6993_RS26145	COG0024	Methionine aminopeptidase
C6993_RS26180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C6993_RS26185	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6993_RS26190	COG0575	Belongs to the CDS family
C6993_RS26195	COG0750	zinc metalloprotease
C6993_RS26205	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
C6993_RS26210	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6993_RS26235	COG0587	DNA-directed DNA polymerase activity
C6993_RS26245	COG1982	Orn Lys Arg decarboxylase major
C6993_RS26250	COG0346	lactoylglutathione lyase activity
C6993_RS26260	COG4568	rho-dependent transcription termination
C6993_RS26270	COG4681	YaeQ
C6993_RS26275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C6993_RS26280	COG3015	lipoprotein NlpE involved in copper resistance
C6993_RS26290	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS26305	COG1720	tRNA m6t6A37 methyltransferase activity
C6993_RS26315	COG1464	Belongs to the NlpA lipoprotein family
C6993_RS26320	COG2011	ABC-type metal ion transport system permease component
C6993_RS26325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C6993_RS26330	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C6993_RS26365	COG0656	L-ascorbic acid biosynthetic process
C6993_RS26370	COG0583	DNA-binding transcription factor activity
C6993_RS26380	COG2226	methyltransferase
C6993_RS26385	COG1388	LysM domain
C6993_RS26385	COG0741	lytic transglycosylase activity
C6993_RS26395	COG2226	methyltransferase
C6993_RS26405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6993_RS26430	COG4104	PAAR repeat-containing protein
C6993_RS26435	COG3157	Type VI secretion system effector, Hcp
C6993_RS26485	COG3209	COG3209 Rhs family protein
C6993_RS26515	COG1960	acyl-CoA dehydrogenase activity
C6993_RS26525	COG0121	glutamine amidotransferase
C6993_RS26530	COG3034	peptidoglycan biosynthetic process
C6993_RS26535	COG3041	Addiction module toxin RelE StbE family
C6993_RS26540	COG3077	Addiction module antitoxin, RelB DinJ family
C6993_RS26545	COG0791	NLP P60 protein
C6993_RS26575	COG1987	bacterial-type flagellum assembly
C6993_RS26600	COG1677	Flagellar hook-basal body complex protein FliE
C6993_RS26610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C6993_RS26630	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C6993_RS26660	COG1815	bacterial-type flagellum-dependent cell motility
C6993_RS26665	COG1558	bacterial-type flagellum-dependent cell motility
C6993_RS26675	COG1749	Flagellar hook protein flgE
C6993_RS26680	COG4787	bacterial-type flagellum-dependent cell motility
C6993_RS26685	COG4786	Flagellar basal body rod
C6993_RS26710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6993_RS26725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C6993_RS26735	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C6993_RS26760	COG1191	sigma factor activity
C6993_RS26765	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C6993_RS26780	COG0454	-acetyltransferase
C6993_RS26790	COG1690	Belongs to the RtcB family
C6993_RS26795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C6993_RS26800	COG2195	Cleaves the N-terminal amino acid of tripeptides
C6993_RS26820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C6993_RS26915	COG0727	PFAM Uncharacterised protein family (UPF0153)
C6993_RS26930	COG3188	usher protein
C6993_RS26980	COG1388	LysM domain
C6993_RS26985	COG2207	Transcriptional regulator
C6993_RS26985	COG3708	Transcriptional regulator
C6993_RS26990	COG0656	L-ascorbic acid biosynthetic process
C6993_RS26995	COG3059	membrane
C6993_RS27005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6993_RS27010	COG2207	Transcriptional regulator
C6993_RS27015	COG0247	lactate metabolic process
C6993_RS27020	COG1139	Iron-sulfur cluster binding protein
C6993_RS27025	COG1556	Lactate utilization protein
C6993_RS27065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6993_RS27075	COG2200	EAL domain
C6993_RS27075	COG2771	luxR family
C6993_RS27080	COG0583	DNA-binding transcription factor activity
C6993_RS27095	COG0666	response to abiotic stimulus
C6993_RS27105	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C6993_RS27110	COG1304	FMN binding
C6993_RS27115	COG0549	Belongs to the carbamate kinase family
C6993_RS27120	COG0402	S-adenosylhomocysteine deaminase activity
C6993_RS27130	COG1879	ABC-type sugar transport system periplasmic component
C6993_RS27135	COG1129	ABC transporter
C6993_RS27140	COG1172	Belongs to the binding-protein-dependent transport system permease family
C6993_RS27150	COG1064	alcohol dehydrogenase
C6993_RS27165	COG1280	lysine exporter protein (LysE YggA)
C6993_RS27175	COG3829	transcription factor binding
C6993_RS27180	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C6993_RS27185	COG0372	Belongs to the citrate synthase family
C6993_RS27190	COG2079	MmgE PrpD family protein
C6993_RS27195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6993_RS27200	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C6993_RS27205	COG0402	S-adenosylhomocysteine deaminase activity
C6993_RS27210	COG0583	DNA-binding transcription factor activity
C6993_RS27215	COG0288	reversible hydration of carbon dioxide
C6993_RS27225	COG2807	transmembrane transport
C6993_RS27230	COG2223	nitrite transmembrane transporter activity
C6993_RS27235	COG3250	beta-galactosidase activity
C6993_RS27245	COG1609	Transcriptional regulator
C6993_RS27250	COG1414	Transcriptional regulator
C6993_RS27285	COG2814	Major facilitator Superfamily
C6993_RS27290	COG3122	Protein conserved in bacteria
C6993_RS27320	COG1215	transferase activity, transferring glycosyl groups
C6993_RS27325	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C6993_RS27335	COG4521	taurine ABC transporter
C6993_RS27340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C6993_RS27345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6993_RS27355	COG0113	porphobilinogen synthase activity
C6993_RS27380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6993_RS27385	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6993_RS27395	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C6993_RS27420	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6993_RS27435	COG1785	Belongs to the alkaline phosphatase family
C6993_RS27445	COG3706	GGDEF domain
C6993_RS27450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C6993_RS27475	COG4126	flavin adenine dinucleotide binding
C6993_RS27500	COG1940	carbohydrate kinase activity
C6993_RS27505	COG2814	Major facilitator Superfamily
C6993_RS27510	COG0419	ATPase involved in DNA repair
C6993_RS27515	COG0420	3'-5' exonuclease activity
C6993_RS27520	COG0745	RESPONSE REGULATOR receiver
C6993_RS27525	COG5002	protein histidine kinase activity
C6993_RS27530	COG1114	Component of the transport system for branched-chain amino acids
C6993_RS27535	COG1113	amino acid transport
C6993_RS27540	COG0366	Alpha amylase catalytic
C6993_RS27560	COG1862	Preprotein translocase
C6993_RS27565	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6993_RS27570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C6993_RS27575	COG1403	HNH endonuclease
C6993_RS27580	COG3248	Nucleoside-binding outer membrane protein
C6993_RS27585	COG4238	major outer membrane lipoprotein
C6993_RS27595	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6993_RS27595	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6993_RS27610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C6993_RS27615	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C6993_RS27620	COG0667	Aldo Keto reductase
C6993_RS27630	COG0142	geranyltranstransferase activity
C6993_RS27645	COG0693	protein deglycase activity
C6993_RS27650	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C6993_RS27660	COG2814	Major facilitator Superfamily
C6993_RS27685	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C6993_RS27690	COG1845	cytochrome c oxidase, subunit III
C6993_RS27695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6993_RS27700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6993_RS27705	COG2223	nitrite transmembrane transporter activity
C6993_RS27710	COG3056	Lipoprotein
C6993_RS27715	COG0271	Belongs to the BolA IbaG family
C6993_RS27740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C6993_RS27745	COG0776	regulation of translation
C6993_RS27750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6993_RS27755	COG1555	photosystem II stabilization
C6993_RS27760	COG0824	Thioesterase
C6993_RS27770	COG4533	DNA binding
C6993_RS27780	COG1522	sequence-specific DNA binding
C6993_RS27785	COG1132	(ABC) transporter
C6993_RS27790	COG1132	(ABC) transporter
C6993_RS27795	COG0347	Belongs to the P(II) protein family
C6993_RS27800	COG0004	ammonium transporteR
C6993_RS27805	COG1946	Acyl-CoA thioesterase
C6993_RS27810	COG3126	Type III secretion system lipoprotein chaperone (YscW)
C6993_RS27815	COG3695	enzyme binding
C6993_RS27825	COG5507	3-demethylubiquinone-9 3-methyltransferase
C6993_RS27830	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C6993_RS27840	COG0110	maltose O-acetyltransferase activity
C6993_RS27855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6993_RS27860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6993_RS27865	COG1309	transcriptional regulator
C6993_RS27875	COG1196	nuclear chromosome segregation
C6993_RS27875	COG3264	Mechanosensitive ion channel
C6993_RS27880	COG3547	Transposase (IS116 IS110 IS902 family)
C6993_RS27895	COG3923	Primosomal replication protein n
C6993_RS27900	COG2832	Protein of unknown function (DUF454)
C6993_RS27915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C6993_RS27955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6993_RS27960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6993_RS27960	COG4651	solute:proton antiporter activity
C6993_RS27965	COG2223	nitrite transmembrane transporter activity
C6993_RS27975	COG0737	Belongs to the 5'-nucleotidase family
C6993_RS27980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C6993_RS27990	COG3735	TraB family
C6993_RS28000	COG3093	addiction module antidote protein HigA
C6993_RS28005	COG2217	Heavy metal translocating P-type atpase
C6993_RS28015	COG0531	amino acid
C6993_RS28020	COG0789	Transcriptional regulator
C6993_RS28025	COG1585	Membrane protein implicated in regulation of membrane protease activity
C6993_RS28030	COG0330	HflC and HflK could
C6993_RS28035	COG4619	ABC transporter
C6993_RS28040	COG0390	transport system, permease component
C6993_RS28045	COG3118	belongs to the thioredoxin family
C6993_RS28050	COG0300	oxidoreductase activity
C6993_RS28055	COG2755	lipolytic protein G-D-S-L family
C6993_RS28060	COG4181	ATPase activity
C6993_RS28065	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C6993_RS28090	COG0583	DNA-binding transcription factor activity
C6993_RS28100	COG1414	Transcriptional regulator
C6993_RS28105	COG3960	tartronate-semialdehyde synthase activity
C6993_RS28110	COG3622	Belongs to the hyi family
C6993_RS28115	COG2084	Dehydrogenase
C6993_RS28120	COG1953	Uracil, thiamine, allantoin
C6993_RS28135	COG1929	Belongs to the glycerate kinase type-1 family
C6993_RS28140	COG3257	ureidoglycine aminohydrolase activity
C6993_RS28145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6993_RS28150	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C6993_RS28155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C6993_RS28160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C6993_RS28170	COG0549	Belongs to the carbamate kinase family
C6993_RS28175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C6993_RS28180	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C6993_RS28195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C6993_RS28205	COG1988	membrane-bound metal-dependent
C6993_RS28210	COG2501	S4 domain
C6993_RS28220	COG3539	Fimbrial protein
C6993_RS28225	COG3121	Chaperone
C6993_RS28230	COG3188	usher protein
C6993_RS28235	COG3539	Fimbrial protein
C6993_RS28240	COG3539	Fimbrial protein
C6993_RS28245	COG2197	response regulator
C6993_RS28255	COG0582	viral genome integration into host DNA
C6993_RS28265	COG0582	viral genome integration into host DNA
C6993_RS28430	COG3772	lysozyme
C6993_RS28455	COG4220	transposase activity
C6993_RS28480	COG4372	Transposase
C6993_RS28485	COG3436	PFAM IS66 Orf2 family protein
C6993_RS28580	COG5301	cellulose 1,4-beta-cellobiosidase activity
C6993_RS28585	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C6993_RS28595	COG0500	methyltransferase
C6993_RS28610	COG4571	Outer membrane protease
C6993_RS28625	COG2207	Transcriptional regulator
C6993_RS28640	COG4783	chaperone-mediated protein folding
C6993_RS28645	COG1215	transferase activity, transferring glycosyl groups
C6993_RS28650	COG5433	transposase activity
C6993_RS28655	COG4104	PAAR repeat-containing protein
C6993_RS28655	COG3209	COG3209 Rhs family protein
C6993_RS28670	COG4104	PAAR repeat-containing protein
C6993_RS28670	COG3209	COG3209 Rhs family protein
C6993_RS28680	COG3501	Rhs element vgr protein
C6993_RS28685	COG5002	protein histidine kinase activity
C6993_RS28690	COG0745	RESPONSE REGULATOR receiver
C6993_RS28700	COG1538	Outer membrane efflux protein
C6993_RS28705	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6993_RS28710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6993_RS28715	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6993_RS28720	COG1113	amino acid transport
C6993_RS28725	COG0668	transmembrane transport
C6993_RS28730	COG0778	Nitroreductase
C6993_RS28735	COG2315	Protein conserved in bacteria
C6993_RS28770	COG2977	Belongs to the P-Pant transferase superfamily
C6993_RS28775	COG4771	TonB-dependent receptor
C6993_RS28785	COG2382	esterase
C6993_RS28790	COG3251	PFAM MbtH domain protein
C6993_RS28795	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C6993_RS28795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C6993_RS28800	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
C6993_RS28805	COG1120	ATPase activity
C6993_RS28810	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6993_RS28815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6993_RS28825	COG4592	Periplasmic binding protein
C6993_RS28835	COG1169	isochorismate synthase
C6993_RS28840	COG1021	2,3-dihydroxybenzoate-AMP ligase
C6993_RS28845	COG3433	isochorismatase activity
C6993_RS28845	COG1535	isochorismatase
C6993_RS28850	COG1028	Short-chain dehydrogenase reductase Sdr
C6993_RS28855	COG2050	protein possibly involved in aromatic compounds catabolism
C6993_RS28860	COG1966	Carbon starvation protein
C6993_RS28865	COG2879	small protein
C6993_RS28870	COG0371	Dehydrogenase
C6993_RS28875	COG0436	Aminotransferase
C6993_RS28880	COG1475	DNA binding
C6993_RS28885	COG3969	phosphoadenosine phosphosulfate
C6993_RS28890	COG0583	DNA-binding transcription factor activity
C6993_RS28895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C6993_RS28900	COG0450	alkyl hydroperoxide reductase
C6993_RS28905	COG3634	alkyl hydroperoxide reductase activity
C6993_RS28910	COG0589	response to stress
C6993_RS28915	COG1063	alcohol dehydrogenase
C6993_RS28925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6993_RS28935	COG3719	Belongs to the RNase T2 family
C6993_RS28940	COG0471	metal ion transport
C6993_RS28955	COG3051	citrate lyase alpha subunit
C6993_RS28960	COG2301	Belongs to the HpcH HpaI aldolase family
C6993_RS28970	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
C6993_RS28975	COG3290	protein histidine kinase activity
C6993_RS28980	COG4565	transcriptional regulatory protein
C6993_RS28985	COG3069	C4-dicarboxylate transmembrane transporter activity
C6993_RS29010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6993_RS29015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6993_RS29030	COG0583	DNA-binding transcription factor activity
C6993_RS29050	COG1686	Belongs to the peptidase S11 family
C6993_RS29055	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C6993_RS29060	COG0772	Belongs to the SEDS family
C6993_RS29065	COG0768	penicillin binding
C6993_RS29075	COG0799	negative regulation of ribosome biogenesis
C6993_RS29080	COG0406	alpha-ribazole phosphatase activity
C6993_RS29090	COG1466	dna polymerase III delta subunit
C6993_RS29105	COG2888	peptidyl-tyrosine sulfation
C6993_RS29110	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C6993_RS29120	COG2214	Heat shock protein DnaJ domain protein
C6993_RS29125	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
C6993_RS29135	COG2214	Heat shock protein DnaJ domain protein
C6993_RS29140	COG0443	Heat shock 70 kDa protein
C6993_RS29150	COG1126	abc transporter atp-binding protein
C6993_RS29155	COG0765	amino acid transport
C6993_RS29160	COG0765	amino acid transport
C6993_RS29165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6993_RS29180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C6993_RS29185	COG4535	Mg2 and Co2 transporter CorC
C6993_RS29195	COG1702	phosphate starvation-inducible protein PhoH
C6993_RS29205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6993_RS29250	COG0367	asparagine synthase
C6993_RS29260	COG0647	UMP catabolic process
C6993_RS29265	COG1940	carbohydrate kinase activity
C6993_RS29265	COG1846	Transcriptional regulator
C6993_RS29270	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C6993_RS29280	COG2190	(PTS) system
C6993_RS29280	COG1263	PTS System
C6993_RS29280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C6993_RS29305	COG0735	belongs to the Fur family
C6993_RS29315	COG0716	FMN binding
C6993_RS29325	COG0596	Alpha beta hydrolase
C6993_RS29330	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
C6993_RS29335	COG0033	Phosphoglucomutase
C6993_RS29340	COG0531	amino acid
C6993_RS29345	COG1982	Orn Lys Arg decarboxylase major
C6993_RS29360	COG0745	RESPONSE REGULATOR receiver
C6993_RS29365	COG2205	protein histidine kinase activity
C6993_RS29395	COG3209	COG3209 Rhs family protein
C6993_RS29420	COG3272	Protein of unknown function (DUF1722)
C6993_RS29425	COG0415	Belongs to the DNA photolyase family
C6993_RS29435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C6993_RS29440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C6993_RS29445	COG1984	allophanate hydrolase subunit 2
C6993_RS29460	COG3180	Ammonia monooxygenase
C6993_RS29465	COG3539	Fimbrial protein
C6993_RS29470	COG3121	Chaperone
C6993_RS29475	COG3188	usher protein
C6993_RS29480	COG3539	Fimbrial protein
C6993_RS29485	COG0372	Belongs to the citrate synthase family
C6993_RS29500	COG2009	succinate dehydrogenase
C6993_RS29505	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C6993_RS29510	COG1053	succinate dehydrogenase
C6993_RS29515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C6993_RS29520	COG0567	Dehydrogenase, E1 component
C6993_RS29525	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6993_RS29535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C6993_RS29540	COG2188	Transcriptional regulator
C6993_RS29545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS29545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6993_RS29545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6993_RS29550	COG0383	alpha-mannosidase activity
C6993_RS29560	COG1271	oxidase subunit
C6993_RS29565	COG1294	oxidase, subunit
C6993_RS29570	COG4890	Cyd operon protein YbgT
C6993_RS29575	COG3790	cyd operon protein YbgE
C6993_RS29580	COG0824	Thioesterase
C6993_RS29585	COG0811	peptide transport
C6993_RS29590	COG0848	biopolymer transport protein
C6993_RS29595	COG3064	Membrane
C6993_RS29605	COG2885	chlorophyll binding
C6993_RS29610	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C6993_RS29620	COG4372	Transposase
C6993_RS29625	COG3436	PFAM IS66 Orf2 family protein
C6993_RS29655	COG3468	outer membrane autotransporter barrel domain protein
C6993_RS29670	COG1585	Membrane protein implicated in regulation of membrane protease activity
C6993_RS29865	COG4372	Transposase
C6993_RS29870	COG3436	PFAM IS66 Orf2 family protein
C6993_RS29895	COG3436	PFAM IS66 Orf2 family protein
C6993_RS29900	COG4372	Transposase
C6993_RS30020	COG4372	Transposase
C6993_RS30025	COG3436	PFAM IS66 Orf2 family protein
C6993_RS30145	COG0726	polysaccharide deacetylase
C6993_RS30150	COG0297	glycogen (starch) synthase activity
C6993_RS30155	COG2194	sulfuric ester hydrolase activity
C6993_RS30170	COG4372	Transposase