locus-tag class description H0E72_RS00010 ENOG4105VZ1 Replication Protein H0E72_RS00040 ENOG4105ED4 portal protein H0E72_RS00130 ENOG4108X9F tail fiber protein H0E72_RS00135 ENOG4105UZW Tail fiber assembly protein H0E72_RS00180 ENOG4105ZTC transcriptional activator, Ogr delta H0E72_RS00185 ENOG4105VNT transposase (IS4 family) protein H0E72_RS00200 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein H0E72_RS00215 ENOG4105EBK exported protein H0E72_RS00220 ENOG4108VTS Membrane H0E72_RS00225 ENOG41065TG regulatoR H0E72_RS00235 ENOG4105DP0 ferredoxin-NADP reductase H0E72_RS00240 ENOG4105CBT Fructose-1,6-bisphosphatase H0E72_RS00250 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H0E72_RS00275 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase H0E72_RS00290 ENOG41063M6 Cell Division Protein H0E72_RS00295 ENOG4105ETE Transcriptional regulator (LacI family H0E72_RS00300 ENOG4105C25 Primosomal protein n' H0E72_RS00310 ENOG4107S01 Repressor protein MetJ H0E72_RS00320 ENOG4105C28 cystathionine H0E72_RS00325 ENOG4105CFH Aspartokinase H0E72_RS00330 ENOG4105DRB nucleoside-specific channel-forming protein H0E72_RS00335 ENOG4105CGH 5'-nucleotidase H0E72_RS00340 ENOG4105CGH 5'-nucleotidase H0E72_RS00350 ENOG4105CGH 5'-nucleotidase H0E72_RS00355 ENOG4105SYT Methylenetetrahydrofolate reductase H0E72_RS00365 ENOG4108Q5Y Membrane H0E72_RS00370 ENOG4108XC3 NADH ubiquinone oxidoreductase H0E72_RS00375 ENOG4105DCT glycerol dehydrogenase H0E72_RS00380 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H0E72_RS00385 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H0E72_RS00390 ENOG4105DM4 PTS System H0E72_RS00395 ENOG4108YRF PTS System H0E72_RS00405 ENOG4108AHH pyruvate formate lyase II activase H0E72_RS00410 ENOG4108XCZ PTS System H0E72_RS00415 ENOG4106R3P AraC family transcriptional regulator H0E72_RS00420 ENOG4105DIJ Phosphoethanolamine transferase H0E72_RS00435 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase H0E72_RS00450 ENOG4105C5Q Transcriptional regulator H0E72_RS00460 ENOG4105EJ2 Transcriptional regulator H0E72_RS00465 ENOG4108Y73 Membrane H0E72_RS00475 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) H0E72_RS00510 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase H0E72_RS00545 ENOG4105PM1 preprotein translocase subunit SecE H0E72_RS00550 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) H0E72_RS00585 ENOG4105D41 biosynthesis protein thiH H0E72_RS00595 ENOG4105WHD thiamine biosynthesis protein ThiS H0E72_RS00600 ENOG4105D06 uba thif-type nad fad binding protein H0E72_RS00635 ENOG4105R2J Conserved Protein H0E72_RS00645 ENOG4108T8B Protein of unknown function (DUF1481) H0E72_RS00650 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism H0E72_RS00655 ENOG4105BZU Histidine kinase H0E72_RS00660 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H0E72_RS00665 ENOG4105C12 Phosphoribosylglycinamide synthetase H0E72_RS00715 ENOG4107QP3 malate synthase g H0E72_RS00720 ENOG4108I9X Isocitrate lyase H0E72_RS00730 ENOG41069M3 Transcriptional regulator H0E72_RS00735 ENOG4105C3R Methionine synthase H0E72_RS00740 ENOG4105EAM Na Pi-cotransporter H0E72_RS00750 ENOG4105F9E Shikimate 5-dehydrogenase H0E72_RS00755 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein H0E72_RS00760 ENOG4105F3R pts system mannose fructose sorbose family iid H0E72_RS00765 ENOG4105ETZ PTS System H0E72_RS00770 ENOG4105KPI PTS system sorbose subfamily IIB component H0E72_RS00775 ENOG4108XCU pts system H0E72_RS00780 ENOG4105CHR reductase H0E72_RS00785 ENOG4105DKT Transcriptional regulator H0E72_RS00790 ENOG4105FE9 pseudouridine synthase H0E72_RS00795 ENOG4108ZR5 Conserved Protein H0E72_RS00800 ENOG4105CFH Aspartokinase H0E72_RS00815 ENOG4108MDC (LipO)protein H0E72_RS00820 ENOG4108Q9C Periplasmic Protein H0E72_RS00825 ENOG4105E3R (LipO)protein H0E72_RS00840 ENOG4105EG2 ABC transporter, permease H0E72_RS00845 ENOG4105D56 permease protein H0E72_RS00850 ENOG4107FKK extracellular solute-binding protein family 1 H0E72_RS00855 ENOG4108IJ9 (ABC) transporter H0E72_RS00865 ENOG4107W52 maltose operon periplasmic protein H0E72_RS00890 ENOG41080IJ Diacylglycerol kinase H0E72_RS00900 ENOG4107R73 Mate efflux family protein H0E72_RS00905 ENOG4105VDW Csbd family H0E72_RS00910 ENOG4105MYN Zinc uptake regulation protein H0E72_RS00920 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H0E72_RS00925 ENOG4105P4Z Phage shock protein G H0E72_RS00930 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein H0E72_RS00935 ENOG4105CDU Replicative dna helicase H0E72_RS00940 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H0E72_RS00945 ENOG4105CGF Aromatic amino acid aminotransferase H0E72_RS00955 ENOG4105F0S class B acid phosphatase H0E72_RS00960 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme H0E72_RS00965 ENOG4105MSB protein, conserved in bacteria H0E72_RS00970 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) H0E72_RS00975 ENOG4108UUM single-stranded DNA-binding protein H0E72_RS00980 ENOG4105PMV Membrane H0E72_RS00985 ENOG4108M8H domain protein H0E72_RS00990 ENOG4108W3Q Transcriptional regulator H0E72_RS00995 ENOG4108Z4X TRANSCRIPTIONal H0E72_RS01000 ENOG4105C7N Xanthine uracil vitamin C permease H0E72_RS01005 ENOG4105EEQ Na H antiporter H0E72_RS01015 ENOG41062QD Membrane H0E72_RS01020 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H0E72_RS01030 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit H0E72_RS01035 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0E72_RS01040 ENOG4105DVI reductase, NrfD H0E72_RS01045 ENOG4108QKW cytochrome c-type biogenesis protein H0E72_RS01055 ENOG4108W0S formate-dependent nitrite reductase complex H0E72_RS01060 ENOG4105CK2 sodium dicarboxylate symporter H0E72_RS01065 ENOG41082ND Uncharacterized protein yjcO H0E72_RS01075 ENOG4105ETP RND efflux system, outer membrane lipoprotein H0E72_RS01080 ENOG4108MI0 Resistance protein H0E72_RS01085 ENOG4105J12 Multidrug resistance protein mdtN H0E72_RS01090 ENOG4106833 H0E72_RS01095 ENOG4105EUZ Beta-lactamase domain protein H0E72_RS01100 ENOG4107TFG D-allose kinase H0E72_RS01105 ENOG4105UP7 3-epimerase H0E72_RS01110 ENOG4105CNN ABC, transporter H0E72_RS01115 ENOG4105C2J ABC transporter H0E72_RS01120 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H0E72_RS01125 ENOG4105NYY transcriptional regulator, RpiR H0E72_RS01130 ENOG4108YZG isomerase H0E72_RS01140 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein H0E72_RS01145 ENOG410849A acetyltransferase, (GNAT) family H0E72_RS01155 ENOG4105FD8 phosphonate metabolism protein PhnM H0E72_RS01160 ENOG4105HRV phosphonate c-p lyase system protein phnl H0E72_RS01165 ENOG4105ENV phosphonate C-P lyase system protein PhnK H0E72_RS01170 ENOG4105FT8 Phosphonate metabolism H0E72_RS01175 ENOG4105EKV Phosphonate metabolism protein H0E72_RS01180 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH H0E72_RS01185 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG H0E72_RS01190 ENOG4107RJJ Transcriptional regulator H0E72_RS01200 ENOG4105EHI Phosphonate ABC transporter, periplasmic H0E72_RS01205 ENOG4105D5T phosphonate abc transporter H0E72_RS01210 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase H0E72_RS01215 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA H0E72_RS01220 ENOG4108F5E vimentin H0E72_RS01225 ENOG4108YIV H0E72_RS01230 ENOG4105CSH Transporter H0E72_RS01240 ENOG4105ECM Sensor protein basS pmrB H0E72_RS01245 ENOG4105XJC Two component transcriptional regulator (Winged helix family H0E72_RS01250 ENOG4105DIJ Phosphoethanolamine transferase H0E72_RS01255 ENOG4105D5Q Arginine ornithine antiporter H0E72_RS01260 ENOG4106ZGR Transcriptional regulator H0E72_RS01265 ENOG4105CXN decarboxylase H0E72_RS01270 ENOG4108K2B transcriptional regulator H0E72_RS01275 ENOG4105F8D glycoside hydrolase family 4 H0E72_RS01280 ENOG4105CT4 transporter H0E72_RS01285 ENOG4108R5S membrane H0E72_RS01290 ENOG4107GFK fumarate H0E72_RS01295 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H0E72_RS01300 ENOG4108MRH transcriptional regulatory protein H0E72_RS01305 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism H0E72_RS01310 ENOG4105VR1 Pfam:DUF1271 H0E72_RS01315 ENOG410830R acetyltransferase H0E72_RS01330 ENOG4105CRK lysyL-tRNA synthetase H0E72_RS01335 ENOG4105DUX Transporter H0E72_RS01340 ENOG4105CXN decarboxylase H0E72_RS01345 ENOG4105D5Q Arginine ornithine antiporter H0E72_RS01350 ENOG4108M3R transcriptional activator CadC H0E72_RS01360 ENOG4108SIC Transcriptional regulator H0E72_RS01375 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter H0E72_RS01380 ENOG4108IJ0 Aspartate ammonia-lyase H0E72_RS01385 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 H0E72_RS01390 ENOG4105DVH amino acid H0E72_RS01405 ENOG4108ZVF (LipO)protein H0E72_RS01410 ENOG4105MTB Uncharacterized protein YjeJ H0E72_RS01415 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein H0E72_RS01425 ENOG4107PEH Entericidin EcnA/B family H0E72_RS01430 ENOG4106BSU Entericidin B H0E72_RS01435 ENOG4105KPY Small multidrug resistance protein H0E72_RS01440 ENOG4105QNF Outer membrane lipoprotein H0E72_RS01445 ENOG41066YJ Beta-lactamase H0E72_RS01460 ENOG4105E33 succinate dehydrogenase H0E72_RS01465 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) H0E72_RS01475 ENOG4107SC7 Inner membrane transporter yjeM H0E72_RS01480 ENOG4106V5W H0E72_RS01485 ENOG4106CG8 Inner membrane protein YjeO H0E72_RS01490 ENOG4105EGS Mechanosensitive ion channel H0E72_RS01530 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) H0E72_RS01535 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) H0E72_RS01540 ENOG4105K8N protein family UPF0079, ATPase H0E72_RS01545 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H0E72_RS01565 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) H0E72_RS01570 ENOG4107QJR hflk protein H0E72_RS01575 ENOG4105EPW hflc protein H0E72_RS01595 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) H0E72_RS01600 ENOG4105C2N RNA methyltransferase TrmH family group 3 H0E72_RS01605 ENOG4105FUX Conserved Protein H0E72_RS01610 ENOG4108P9J Phage shock protein A H0E72_RS01615 ENOG4107VNS Protein of unknown function (DUF2491) H0E72_RS01620 ENOG4105Z6B inner membrane protein yjfl H0E72_RS01625 ENOG4108KXT Conserved Protein H0E72_RS01630 ENOG4106032 Glutathionylspermidine synthase H0E72_RS01635 ENOG4105CSU acyl-Coa dehydrogenase H0E72_RS01640 ENOG4105S17 UPF0379 protein yjfN H0E72_RS01645 ENOG4105WSB biofilm stress and motility protein A H0E72_RS01650 ENOG4108MXZ Esterase H0E72_RS01665 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC H0E72_RS01675 ENOG4106ETB IIa component H0E72_RS01695 ENOG4105KIT UPF0379 protein yjfY H0E72_RS01710 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) H0E72_RS01720 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H0E72_RS01725 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H0E72_RS01730 ENOG41069H7 transport system small permease component H0E72_RS01735 ENOG4107S3R L-aspartate oxidase H0E72_RS01740 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) H0E72_RS01745 ENOG4105E39 Enoyl-CoA hydratase H0E72_RS01755 ENOG4105CHR reductase H0E72_RS01765 ENOG4105FHY Opacity-associated protein A H0E72_RS01770 ENOG4108V1T peptidylprolyl cis-trans isomerase H0E72_RS01795 ENOG4105DXC membrane H0E72_RS01800 ENOG4105ECR NmrA family H0E72_RS01805 ENOG4105KVH Transcriptional regulator H0E72_RS01810 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic H0E72_RS01815 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase H0E72_RS01820 ENOG4108UUE Transcriptional regulator H0E72_RS01825 ENOG41061GZ Protein of unknown function (DUF1107) H0E72_RS01830 ENOG4105C37 (CBS) domain H0E72_RS01840 ENOG4105CFU surface antigen H0E72_RS01845 ENOG4105MA0 exported protein H0E72_RS01850 ENOG4108ZHD aig2 family H0E72_RS01855 ENOG41087RY SpoVT_AbrB H0E72_RS01860 ENOG4105MZG transcriptional modulator of maze toxin, mazf H0E72_RS01865 ENOG4105F0N pyrophosphate phospho-hydrolase H0E72_RS01870 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator H0E72_RS01875 ENOG4105C2J ABC transporter H0E72_RS01880 ENOG4107R9N ABC transporter H0E72_RS01885 ENOG41062B0 ABC transporter, permease H0E72_RS01895 ENOG4105DFU Cell wall formation (By similarity) H0E72_RS01905 ENOG4105CMS peptidase U62, modulator of DNA gyrase H0E72_RS01910 ENOG4108XVM Cytochrome b(562) H0E72_RS01920 ENOG4105K4U addiction module toxin, RelE StbE family H0E72_RS01925 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) H0E72_RS01930 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase H0E72_RS01935 ENOG4105CG3 alpha amylase, catalytic region H0E72_RS01940 ENOG4105C5Y PTS System H0E72_RS01945 ENOG4105D4X repressor H0E72_RS01955 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic H0E72_RS01960 ENOG4105KME endoribonuclease L-psp H0E72_RS01975 ENOG4107C93 pyrBI operon leader peptide H0E72_RS01980 ENOG4108UQ8 endoribonuclease L-psp H0E72_RS01985 ENOG4105F6U Short-chain dehydrogenase reductase Sdr H0E72_RS01990 ENOG4108XFH Transcriptional regulator H0E72_RS01995 ENOG4105XEP YhcH YjgK YiaL family protein H0E72_RS02010 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) H0E72_RS02015 ENOG4108MJ3 acetyltransferase H0E72_RS02020 ENOG4108M3P Membrane H0E72_RS02025 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) H0E72_RS02030 ENOG4105MYG DNA polymerase iii, chi subunit H0E72_RS02040 ENOG4108M8S permease YjgP YjgQ family protein H0E72_RS02045 ENOG4108K5H permease YjgP YjgQ family protein H0E72_RS02050 ENOG4105D7A ATP-binding protein H0E72_RS02055 ENOG4105K2J Transcriptional regulator H0E72_RS02060 ENOG4105C6Z Gluconate H0E72_RS02065 ENOG4105CHR reductase H0E72_RS02070 ENOG4105CPQ Dehydrogenase H0E72_RS02075 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H0E72_RS02080 ENOG4105DQ4 alcohol dehydrogenase H0E72_RS02225 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) H0E72_RS02235 ENOG4108I5C dEAD DEAH box helicase H0E72_RS02240 ENOG4105C4R Atp-dependent dna helicase H0E72_RS02265 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria H0E72_RS02270 ENOG4108W9T type 1 fimbriae regulatory protein H0E72_RS02275 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off H0E72_RS02280 ENOG4108RQP Major type 1 subunit fimbrin H0E72_RS02285 ENOG4108S54 Fimbrial protein H0E72_RS02290 ENOG4108NAE Fimbrial chaperone protein H0E72_RS02295 ENOG4105CW0 outer membrane usher protein H0E72_RS02300 ENOG4108SQA Fimbrial H0E72_RS02305 ENOG4108T65 Fimbrial H0E72_RS02310 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin H0E72_RS02320 ENOG4105VNT transposase (IS4 family) protein H0E72_RS02335 ENOG4105DEI Mannitol dehydrogenase H0E72_RS02340 ENOG4105C6F GntR Family Transcriptional Regulator H0E72_RS02360 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H0E72_RS02365 ENOG4108UTZ Dihydroxyacetone kinase H0E72_RS02370 ENOG4105CMT Dihydroxyacetone kinase H0E72_RS02385 ENOG4107QN2 dihydrolipoyl dehydrogenase H0E72_RS02395 ENOG4105BZW Glycerate kinase H0E72_RS02400 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H0E72_RS02405 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H0E72_RS02410 ENOG41060W2 glyoxylate carboligase H0E72_RS02415 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family H0E72_RS02425 ENOG4105DFD Na H antiporter H0E72_RS02430 ENOG4107YNJ LysR family Transcriptional regulator H0E72_RS02435 ENOG4105DYB Isoaspartyl dipeptidase H0E72_RS02440 ENOG4108P2H Inner membrane protein YjiG H0E72_RS02445 ENOG41074DU domain protein H0E72_RS02455 ENOG4105TNG K13735 adhesin invasin H0E72_RS02460 ENOG4105CBP Major Facilitator H0E72_RS02465 ENOG4108ZK4 sdia-regulated domain-containing protein H0E72_RS02480 ENOG4105CIZ coA-substrate-specific enzyme activase H0E72_RS02485 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase H0E72_RS02490 ENOG4106BRA Membrane H0E72_RS02495 ENOG41083G8 Multidrug resistance protein MdtM H0E72_RS02510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H0E72_RS02515 ENOG4106DIZ Domain of unknown function (DUF1127) H0E72_RS02535 ENOG4105C4R Atp-dependent dna helicase H0E72_RS02540 ENOG4105CKI cobalamin synthesis protein H0E72_RS02545 ENOG4105VCD cytoplasmic protein H0E72_RS02550 ENOG4105D22 carbon starvation protein H0E72_RS02570 ENOG4108IA2 Sodium pantothenate symporter H0E72_RS02580 ENOG4105C8Q Methyl-accepting chemotaxis H0E72_RS02585 ENOG4108I5G Major Facilitator superfamily H0E72_RS02590 ENOG410617M Transcriptional regulator H0E72_RS02595 ENOG4105CPQ Dehydrogenase H0E72_RS02605 ENOG4105RI1 glycoprotein receptor H0E72_RS02610 ENOG4106CVF DNA replication protein H0E72_RS02625 ENOG4105DWK Membrane H0E72_RS02630 ENOG4108N8T regulatoR H0E72_RS02635 ENOG4108T94 DNA-binding transcriptional activator BglJ H0E72_RS02640 ENOG4108819 ferric iron reductase H0E72_RS02645 ENOG4105YBH Protein of unknown function (DUF1435) H0E72_RS02670 ENOG4108WPU DNA polymerase III subunit psi H0E72_RS02675 ENOG4105KEG ribosomal-protein-alanine acetyltransferase H0E72_RS02680 ENOG4105PAD Hydrolase H0E72_RS02690 ENOG4105K3G Periplasmic Protein H0E72_RS02700 ENOG4108NRW Phospholipase, patatin family H0E72_RS02705 ENOG4105EYA deoxyribonuclease H0E72_RS02710 ENOG41076CZ activating enzyme H0E72_RS02715 ENOG4105G0K glycine radical enzyme YjjI family H0E72_RS02750 ENOG41062Z9 Membrane H0E72_RS02755 ENOG4105EAC phosphoserine phosphatase H0E72_RS02760 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) H0E72_RS02765 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase H0E72_RS02775 ENOG4105C5H ABC transporter H0E72_RS02780 ENOG4107SC1 transglycosylase H0E72_RS02790 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H0E72_RS02800 ENOG4105UEI Transcriptional Regulator AraC Family H0E72_RS02805 ENOG4108RH0 Crea protein H0E72_RS02810 ENOG4105E3W Two component transcriptional regulator (Winged helix family H0E72_RS02815 ENOG4105EB3 Histidine kinase H0E72_RS02820 ENOG4105CT7 inner membrane cred family protein H0E72_RS02825 ENOG41065U4 response regulator H0E72_RS02830 ENOG410759A H0E72_RS02835 ENOG4106FVC RNA methyltransferase H0E72_RS02845 ENOG4105CFH Aspartokinase H0E72_RS02855 ENOG4105D98 threonine synthase H0E72_RS02860 ENOG41062C6 Protein of unknown function (DUF2502) H0E72_RS02870 ENOG4105BZG amino acid carrier protein H0E72_RS02875 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H0E72_RS02880 ENOG4108RIR Molybdenum cofactor biosynthesis protein H0E72_RS02885 ENOG4106HK8 GPR1 FUN34 yaaH family protein H0E72_RS02890 ENOG4108QUJ UPF0174 protein YaaW H0E72_RS02910 ENOG4105WI6 cell killing protein encoded within cryptic prophage H0E72_RS02920 ENOG41063Z6 transcriptional regulator, lysR family H0E72_RS02945 ENOG410647N response to DNA damage stimulus H0E72_RS02950 ENOG4105DTN riboflavin biosynthesis protein ribF H0E72_RS02955 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) H0E72_RS02965 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase H0E72_RS02985 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain H0E72_RS02990 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain H0E72_RS02995 ENOG4108XNW Transcriptional activatory protein CaiF H0E72_RS03005 ENOG4106YT9 Enoyl-CoA hydratase H0E72_RS03035 ENOG4105C10 Electron transfer flavoprotein H0E72_RS03040 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase H0E72_RS03045 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein H0E72_RS03050 ENOG4105C54 Major Facilitator superfamily H0E72_RS03065 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) H0E72_RS03070 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) H0E72_RS03090 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) H0E72_RS03095 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) H0E72_RS03100 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) H0E72_RS03105 ENOG4105D3G Pseudouridine synthase H0E72_RS03110 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) H0E72_RS03115 ENOG4105CQ2 DNA polymerase H0E72_RS03120 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase H0E72_RS03130 ENOG4105EF1 ribulokinase H0E72_RS03135 ENOG41063TF transcriptional regulator (AraC H0E72_RS03140 ENOG4108KF1 Membrane H0E72_RS03150 ENOG4106SMU thiamine transporter membrane protein H0E72_RS03155 ENOG4105DP9 ABC transporter H0E72_RS03170 ENOG4105S8Q sugar efflux transporter H0E72_RS03185 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H0E72_RS03200 ENOG41064T2 transcriptional regulator, lysR family H0E72_RS03210 ENOG4105C7K acetolactate synthase H0E72_RS03215 ENOG4108ZP8 Acetolactate synthase small subunit H0E72_RS03225 ENOG4107B7Y DNA-binding transcriptional regulator FruR H0E72_RS03240 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) H0E72_RS03245 ENOG4105CJN penicillin-binding protein H0E72_RS03250 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) H0E72_RS03255 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) H0E72_RS03265 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) H0E72_RS03270 ENOG4105CNI cell division protein FtsW H0E72_RS03280 ENOG4105DFU Cell wall formation (By similarity) H0E72_RS03285 ENOG4105CPF Cell wall formation (By similarity) H0E72_RS03290 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) H0E72_RS03295 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) H0E72_RS03300 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) H0E72_RS03310 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) H0E72_RS03320 ENOG4105M6F mutator MutT protein H0E72_RS03335 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) H0E72_RS03350 ENOG4105D7Q type ii secretion system H0E72_RS03355 ENOG4107QHF type ii secretion system protein e H0E72_RS03360 ENOG4108ZUW Major pilin subunit H0E72_RS03365 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H0E72_RS03370 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase H0E72_RS03375 ENOG4106A72 regulatory protein AmpE H0E72_RS03380 ENOG4105C85 amino acid H0E72_RS03385 ENOG41073TP transcriptional regulator H0E72_RS03390 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) H0E72_RS03395 ENOG4107QSN dihydrolipoamide acetyltransferase H0E72_RS03400 ENOG4107QN2 dihydrolipoyl dehydrogenase H0E72_RS03405 ENOG4108NST exported protein H0E72_RS03410 ENOG4107QIJ Aconitate hydratase 2 H0E72_RS03430 ENOG4108ZRK uncharacterized protein yacC H0E72_RS03435 ENOG4105E3B Multicopper oxidase H0E72_RS03440 ENOG4105DZG Dehydrogenase H0E72_RS03445 ENOG4108UGV hypoxanthine phosphoribosyltransferase H0E72_RS03450 ENOG41077A9 carbonic anhydrase H0E72_RS03455 ENOG4105DA5 (ABC) transporter H0E72_RS03460 ENOG4105E3A (ABC) transporter H0E72_RS03465 ENOG4108YTN IIa component H0E72_RS03470 ENOG4107BJW polysaccharide deacetylase H0E72_RS03480 ENOG4108A32 Transposase H0E72_RS03510 ENOG4105SN2 fimbrial-like adhesin protein H0E72_RS03515 ENOG4105SYG Fimbrial protein H0E72_RS03520 ENOG4108XEY fimbrial-like adhesin protein H0E72_RS03525 ENOG4105CW0 outer membrane usher protein H0E72_RS03530 ENOG4108VEV chaperone H0E72_RS03540 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase H0E72_RS03545 ENOG4105DJ0 Poly(A) Polymerase H0E72_RS03565 ENOG4107XID 2'-5' rna ligase H0E72_RS03570 ENOG4105CQ7 ATP-dependent helicase H0E72_RS03575 ENOG4105BZ4 penicillin-binding protein H0E72_RS03580 ENOG4105E0K tonB-dependent siderophore receptor H0E72_RS03585 ENOG4105E0A ABC, transporter H0E72_RS03590 ENOG4105J76 Periplasmic binding protein H0E72_RS03595 ENOG4105S6R Iron-hydroxamate transporter permease subunit H0E72_RS03620 ENOG4105EN6 Membrane H0E72_RS03625 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) H0E72_RS03640 ENOG4105C0H protease H0E72_RS03645 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR H0E72_RS03665 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) H0E72_RS03690 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) H0E72_RS03695 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) H0E72_RS03700 ENOG4105KNE Phosphatidate cytidylyltransferase H0E72_RS03705 ENOG4105DZP Membrane-associated zinc metalloprotease H0E72_RS03715 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) H0E72_RS03720 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) H0E72_RS03745 ENOG4105C0B DNA polymerase III (alpha subunit) H0E72_RS03750 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) H0E72_RS03755 ENOG4105CXN decarboxylase H0E72_RS03760 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase H0E72_RS03765 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) H0E72_RS03770 ENOG4105M1T rho-binding antiterminator H0E72_RS03780 ENOG4108VWS Yaeq family H0E72_RS03785 ENOG4108YZN class I peptide chain release factor H0E72_RS03790 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion H0E72_RS03795 ENOG4108UY0 (LipO)protein H0E72_RS03805 ENOG4108R96 Methyltransferase, YaeB family H0E72_RS03810 ENOG4108R8X outer membrane lipoprotein H0E72_RS03815 ENOG4105D01 (LipO)protein H0E72_RS03820 ENOG4108UMI ABC transporter, permease H0E72_RS03825 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) H0E72_RS03830 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase H0E72_RS03865 ENOG4105CV8 reductase H0E72_RS03870 ENOG4105HEI LysR family (Transcriptional regulator H0E72_RS03880 ENOG4105F2W methyltransferase H0E72_RS03885 ENOG4105E9H Lytic Murein transglycosylase H0E72_RS03895 ENOG4105D1A Methyltransferase H0E72_RS03905 ENOG4107RZZ dna polymerase iii epsilon subunit H0E72_RS03915 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase H0E72_RS03920 ENOG4108WN0 inhibitor of vertebrate lysozyme H0E72_RS03925 ENOG4107QPN acyl-Coa dehydrogenase H0E72_RS03935 ENOG4105E7A Glutamine amidotransferase H0E72_RS03940 ENOG4105F7V ErfK ybiS ycfS ynhG family protein H0E72_RS03955 ENOG4108YS0 lipoprotein YafL H0E72_RS03960 ENOG4108UK5 Transposase H0E72_RS03970 ENOG4105D00 flagellar biosynthetic protein flhB H0E72_RS03975 ENOG4105D19 Role in flagellar biosynthesis (By similarity) H0E72_RS03980 ENOG4105VS8 Flagellar biosynthetic protein fliq H0E72_RS03985 ENOG4105CN7 Flagellar biosynthetic protein FliP H0E72_RS03990 ENOG4105DD5 Flagellar motor switch protein H0E72_RS04010 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) H0E72_RS04015 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H0E72_RS04025 ENOG4108JIR Flagellum-specific ATP synthase H0E72_RS04035 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase H0E72_RS04075 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) H0E72_RS04080 ENOG4108ZC9 flagellar basal-body rod protein flgc H0E72_RS04090 ENOG4105BZE flagellar hook protein, FlgE H0E72_RS04095 ENOG4108KPB Flagellar basal-body rod protein FlgF H0E72_RS04100 ENOG4105CGA flagellar basal-body rod protein FlgG H0E72_RS04115 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj H0E72_RS04125 ENOG4105DTJ flagellar hook-associated protein H0E72_RS04140 ENOG4105I03 Flagellin H0E72_RS04145 ENOG410804A Flagellar hook-associated 2 domain-containing protein H0E72_RS04175 ENOG4107RD7 Flagellar Motor Protein, MotA H0E72_RS04190 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system H0E72_RS04200 ENOG4108HYG acetyltransferase H0E72_RS04210 ENOG4108S2Y peptide Chain Release factor H0E72_RS04215 ENOG4105CIN aminoacyl-histidine dipeptidase H0E72_RS04225 ENOG4105V1F Fermentation respiration switch protein H0E72_RS04235 ENOG4105FCK Membrane H0E72_RS04255 ENOG4105DFP Integrase H0E72_RS04290 ENOG4105MFG Antirestriction protein H0E72_RS04295 ENOG4108XS9 dna repair protein H0E72_RS04300 ENOG4105ZS6 Protein of unknown function (DUF987) H0E72_RS04305 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles H0E72_RS04310 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures H0E72_RS04315 ENOG4105R3P Inner membrane protein yagU H0E72_RS04320 ENOG4105PI0 Ferredoxin H0E72_RS04330 ENOG4106PYX Receptor H0E72_RS04375 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0E72_RS04380 ENOG4105ENX hydrolase H0E72_RS04385 ENOG410642W LysR family Transcriptional regulator H0E72_RS04390 ENOG4105EQ2 LysR family Transcriptional regulator H0E72_RS04395 ENOG4107SET aldo keto reductase H0E72_RS04415 ENOG4105CV8 reductase H0E72_RS04420 ENOG4108KBJ Inner membrane protein YkgB H0E72_RS04425 ENOG41066GK UPF0379 protein ykgI H0E72_RS04430 ENOG4107QN2 dihydrolipoyl dehydrogenase H0E72_RS04435 ENOG4108K01 transcriptional regulator H0E72_RS04440 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H0E72_RS04445 ENOG4107QR9 Iron-sulfur cluster binding protein H0E72_RS04450 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) H0E72_RS04475 ENOG4105C94 Transporter H0E72_RS04480 ENOG4105BZU Histidine kinase H0E72_RS04485 ENOG4108NUU Transcriptional regulator H0E72_RS04490 ENOG4105SZ2 membrAne H0E72_RS04495 ENOG4107SNB ankyrin repeat protein YahD H0E72_RS04500 ENOG4105N16 Protein of unknown function (DUF2877) H0E72_RS04505 ENOG4107R1Q Membrane protein FdrA H0E72_RS04510 ENOG4107REC cytoplasmic protein H0E72_RS04515 ENOG4105C5B carbamate kinase H0E72_RS04520 ENOG4105DZC cytosine deaminase H0E72_RS04525 ENOG4105DQ4 alcohol dehydrogenase H0E72_RS04540 ENOG4105E82 cytochrome subunit of dehydrogenase H0E72_RS04545 ENOG4105TDT uncharacterized protein yahO H0E72_RS04550 ENOG4108JU7 Transcriptional regulator H0E72_RS04555 ENOG4105CR4 methylisocitrate lyase H0E72_RS04560 ENOG4105BZN citrate synthase H0E72_RS04565 ENOG4105DXD 2-methylcitrate dehydratase H0E72_RS04570 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) H0E72_RS04575 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin H0E72_RS04580 ENOG4105DZC cytosine deaminase H0E72_RS04585 ENOG4105DND Transcriptional regulator H0E72_RS04590 ENOG4107B2H carbonic anhydrase H0E72_RS04600 ENOG4105DJ2 Major Facilitator Superfamily H0E72_RS04605 ENOG4108UW5 maltose o-acetyltransferase H0E72_RS04610 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) H0E72_RS04620 ENOG4105ETE Transcriptional regulator (LacI family H0E72_RS04625 ENOG4108K2P TRANSCRIPTIONal H0E72_RS04660 ENOG4108SC4 )-transporter H0E72_RS04665 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme H0E72_RS04685 ENOG4105SRB Uncharacterized protein yaiO H0E72_RS04695 ENOG4108PBI Polysaccharide metabolism H0E72_RS04700 ENOG4107W19 lmbE family H0E72_RS04705 ENOG4106FTQ Taurine ABC transporter, periplasmic H0E72_RS04715 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component H0E72_RS04720 ENOG4105E2B Taurine dioxygenase H0E72_RS04725 ENOG4105D52 delta-aminolevulinic acid dehydratase H0E72_RS04745 ENOG4108PNB DNA-binding transcriptional regulator H0E72_RS04750 ENOG4107R6D beta-lactam binding protein AmpH H0E72_RS04755 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 H0E72_RS04760 ENOG4107QS8 (LipO)protein H0E72_RS04765 ENOG4105FR5 inner membrane protein YaiY H0E72_RS04770 ENOG4105UNH Membrane H0E72_RS04775 ENOG4105CPF Cell wall formation (By similarity) H0E72_RS04790 ENOG4105G6Z alkaline phosphatase H0E72_RS04795 ENOG4105VIF phosphate starvation-inducible protein H0E72_RS04800 ENOG4105BZU Histidine kinase H0E72_RS04805 ENOG4105II7 pyrroline-5-carboxylate reductase H0E72_RS04820 ENOG4105SS3 H0E72_RS04825 ENOG4105HBA AroM protein H0E72_RS04850 ENOG4105DKQ ROK family H0E72_RS04855 ENOG4105F27 Major Facilitator H0E72_RS04860 ENOG4105EYH Exonuclease H0E72_RS04865 ENOG4107RH8 nuclease SbcCD subunit D H0E72_RS04870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H0E72_RS04875 ENOG4105BZU Histidine kinase H0E72_RS04880 ENOG4105CWM branched-chain amino acid transport system II carrier protein H0E72_RS04885 ENOG4105C85 amino acid H0E72_RS04890 ENOG4107R28 alpha amylase, catalytic region H0E72_RS04900 ENOG4108ZYK Acyl carrier protein phosphodiesterase H0E72_RS04915 ENOG4105VIE preprotein translocase, subunit YajC H0E72_RS04920 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H0E72_RS04925 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) H0E72_RS04930 ENOG4105X54 addiction module antidote protein H0E72_RS04940 ENOG4105N1F Hnh endonuclease H0E72_RS04945 ENOG4105DRB nucleoside-specific channel-forming protein H0E72_RS04960 ENOG4105D7V transposase H0E72_RS04975 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) H0E72_RS04980 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) H0E72_RS04990 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) H0E72_RS04995 ENOG4108ZAI phosphatidylglycerophosphatase a H0E72_RS05000 ENOG4105CPC Aldo Keto reductase H0E72_RS05010 ENOG4105CTB Polyprenyl synthetase H0E72_RS05025 ENOG4107S0N DJ-1 family H0E72_RS05030 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) H0E72_RS05040 ENOG4107RDB Major Facilitator H0E72_RS05065 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) H0E72_RS05070 ENOG4105CCU oxidase (Subunit III) H0E72_RS05075 ENOG4105BZ9 Cytochrome C oxidase, subunit I H0E72_RS05080 ENOG4105E2S oxidase) subunit II H0E72_RS05085 ENOG4105EYM Major Facilitator superfamily H0E72_RS05090 ENOG4105IEY (LipO)protein H0E72_RS05095 ENOG4105M85 Bola protein H0E72_RS05115 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) H0E72_RS05120 ENOG4105K70 DNA-binding protein H0E72_RS05125 ENOG4105EIN peptidylprolyl cis-trans isomerase H0E72_RS05130 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein H0E72_RS05135 ENOG4108TGP Thioesterase superfamily protein H0E72_RS05145 ENOG4108NFA extracellular solute-binding protein H0E72_RS05155 ENOG4108XM1 transcriptional regulator AsnC family H0E72_RS05160 ENOG4105BZ1 (ABC) transporter H0E72_RS05165 ENOG4105BZ1 (ABC) transporter H0E72_RS05170 ENOG4108YZA Nitrogen regulatory protein pii H0E72_RS05175 ENOG4105BZU Histidine kinase H0E72_RS05180 ENOG4105C29 acyl-CoA thioesterase H0E72_RS05185 ENOG4108MNP Glycoprotein polysaccharide metabolism H0E72_RS05190 ENOG41080UX Methyltransferase H0E72_RS05200 ENOG4105KCV RNA signal recognition particle 4.5S RNA H0E72_RS05205 ENOG41066DG (EAL) domain protein H0E72_RS05210 ENOG4105GSJ Inner membrane protein ylaC H0E72_RS05215 ENOG4108UW5 maltose o-acetyltransferase H0E72_RS05220 ENOG4105KF5 hemolysin expression-modulating protein H0E72_RS05225 ENOG4108UKR Biofilm formation regulator YbaJ H0E72_RS05230 ENOG4105BZS acriflavin resistance protein H0E72_RS05235 ENOG4105C1P efflux transporter, rnd family, mfp subunit H0E72_RS05240 ENOG4107XI7 Tetr family transcriptional regulator H0E72_RS05245 ENOG4105EGS Mechanosensitive ion channel H0E72_RS05250 ENOG4106428 Protein of unknown function (DUF2496) H0E72_RS05255 ENOG4108URS primosomal replication protein n'' H0E72_RS05260 ENOG4105WD1 Membrane H0E72_RS05270 ENOG4107QMP dna polymerase iii subunits gamma and tau H0E72_RS05305 ENOG4107RE1 Inosine-guanosine kinase H0E72_RS05310 ENOG4105CKD glutathione-regulated potassium-efflux system protein H0E72_RS05315 ENOG4105EU0 Major facilitator Superfamily H0E72_RS05320 ENOG4105CGH 5'-nucleotidase H0E72_RS05325 ENOG4108Z66 YbaK ebsC protein H0E72_RS05330 ENOG4105MBR gumn family H0E72_RS05335 ENOG4105C59 p-type ATPase H0E72_RS05340 ENOG4105CSV Glutaminase H0E72_RS05345 ENOG4107RY6 amino acid H0E72_RS05375 ENOG4105G5H Membrane H0E72_RS05380 ENOG4107QX8 SPFH domain, Band 7 family protein H0E72_RS05385 ENOG41083J0 (ABC) transporter H0E72_RS05390 ENOG4105C4B ABC transporter, permease H0E72_RS05395 ENOG4107QR8 Thioredoxin H0E72_RS05400 ENOG4105E1F short-chain dehydrogenase reductase H0E72_RS05405 ENOG4108UJV acyl-CoA thioesterase i H0E72_RS05410 ENOG4108I0Y (ABC) transporter H0E72_RS05415 ENOG4105CV6 ABC transporter, permease H0E72_RS05425 ENOG4107653 Transcriptional regulator H0E72_RS05435 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region H0E72_RS05440 ENOG41060W2 glyoxylate carboligase H0E72_RS05445 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) H0E72_RS05450 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H0E72_RS05465 ENOG4105BZW Glycerate kinase H0E72_RS05470 ENOG4105S0E allantoin catabolism protein H0E72_RS05475 ENOG4105CE7 Amidase, hydantoinase carbamoylase family H0E72_RS05480 ENOG4105DG4 malate L-lactate dehydrogenase H0E72_RS05485 ENOG4107R1Q Membrane protein FdrA H0E72_RS05490 ENOG4107REC cytoplasmic protein H0E72_RS05495 ENOG4105G5A Protein of unknown function (DUF2877) H0E72_RS05500 ENOG4105C5B carbamate kinase H0E72_RS05505 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit H0E72_RS05510 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) H0E72_RS05520 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H0E72_RS05530 ENOG4105S2T inner membrane protein YbcI H0E72_RS05535 ENOG4105WQ3 Rna-binding protein H0E72_RS05545 ENOG4108WDE Fimbrial protein H0E72_RS05550 ENOG4108AF8 Chaperone H0E72_RS05555 ENOG4105CW0 outer membrane usher protein H0E72_RS05560 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) H0E72_RS05565 ENOG4108ZI2 Fimbrial protein H0E72_RS05570 ENOG4108Q9V regulatoR H0E72_RS05585 ENOG4105QUW H0E72_RS05590 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit H0E72_RS05595 ENOG410802X bacteriophage n4 adsorption protein b H0E72_RS05600 ENOG4105GR3 Histidine kinase H0E72_RS05605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H0E72_RS05610 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H0E72_RS05615 ENOG410624V efflux system protein H0E72_RS05620 ENOG4105EP1 Efflux transporter rnd family, mfp subunit H0E72_RS05625 ENOG4108IJF Heavy metal efflux pump, CzcA H0E72_RS05630 ENOG4105C85 amino acid H0E72_RS05635 ENOG4105CUY Mechanosensitive ion channel H0E72_RS05640 ENOG4108RCM Nitroreductase H0E72_RS05645 ENOG4105MSB protein, conserved in bacteria H0E72_RS05650 ENOG4105WQ6 Membrane H0E72_RS05665 ENOG4108TSE Transferase H0E72_RS05670 ENOG4107RNH Outer membrane receptor FepA H0E72_RS05675 ENOG4105E93 esterase H0E72_RS05680 ENOG41085A6 mbth domain-containing protein H0E72_RS05685 ENOG4105C0W non-ribosomal peptide synthetase H0E72_RS05690 ENOG4108QY5 Ferric enterobactin transport protein H0E72_RS05695 ENOG4105E0A ABC, transporter H0E72_RS05700 ENOG4105TVJ transport system, permease H0E72_RS05705 ENOG4105DQ5 transport system permease protein H0E72_RS05715 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein H0E72_RS05720 ENOG4105E4F Isochorismate synthase H0E72_RS05725 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H0E72_RS05730 ENOG4105WQI isochorismatase H0E72_RS05735 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase H0E72_RS05740 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) H0E72_RS05745 ENOG4105D22 carbon starvation protein H0E72_RS05750 ENOG4105VCD cytoplasmic protein H0E72_RS05755 ENOG4107SCQ Iron-containing alcohol dehydrogenase H0E72_RS05760 ENOG4105CHM Aminotransferase H0E72_RS05765 ENOG4105GTN ParB Domain Protein Nuclease H0E72_RS05770 ENOG4105BZV Phosphoadenosine phosphosulfate reductase H0E72_RS05775 ENOG4105DQS Transcriptional regulator H0E72_RS05780 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase H0E72_RS05785 ENOG4105D3R alkyl hydroperoxide reductase H0E72_RS05790 ENOG4108JU3 Alkyl hydroperoxide reductase H0E72_RS05795 ENOG4108U51 Universal stress protein H0E72_RS05800 ENOG4105NXH GreA GreB family elongation factor H0E72_RS05805 ENOG4105KTS ribonuclease H0E72_RS05810 ENOG4107QPK )-transporter H0E72_RS05825 ENOG4105CHY citrate lyase, alpha H0E72_RS05830 ENOG4105CI0 Citrate lyase H0E72_RS05840 ENOG4105DUA (citrate (pro-3S)-lyase ligase H0E72_RS05845 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism H0E72_RS05850 ENOG4106YYS transcriptional regulatory protein H0E72_RS05855 ENOG4105CEE C4-dicarboxylate transporter H0E72_RS05860 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) H0E72_RS05880 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) H0E72_RS05890 ENOG41064T2 transcriptional regulator, lysR family H0E72_RS05905 ENOG4105DZ1 carboxypeptidase H0E72_RS05910 ENOG4105K6T rare lipoprotein A H0E72_RS05915 ENOG4105CNI cell division protein FtsW H0E72_RS05920 ENOG4105CJN penicillin-binding protein H0E72_RS05930 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) H0E72_RS05935 ENOG4108TGR phosphatase H0E72_RS05945 ENOG4105DJF DNA polymerase III, delta' subunit H0E72_RS05960 ENOG4107PAI alpha helical protein H0E72_RS05965 ENOG4105EUU Sel1 domain protein repeat-containing protein H0E72_RS05970 ENOG41069CF Protein of unknown function (DUF1266) H0E72_RS05975 ENOG4105QFC Hsc56 co-chaperone of HscC H0E72_RS05980 ENOG4107JFD Sel1 repeat H0E72_RS05985 ENOG41069CF Protein of unknown function (DUF1266) H0E72_RS05990 ENOG4105QFC Hsc56 co-chaperone of HscC H0E72_RS05995 ENOG4105F7F Chaperone H0E72_RS06005 ENOG4105CDA abc transporter atp-binding protein H0E72_RS06010 ENOG4105DRP amino acid AbC transporter H0E72_RS06015 ENOG4105EAD ABC transporter H0E72_RS06020 ENOG4107RP9 extracellular solute-binding protein, family 3 H0E72_RS06025 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) H0E72_RS06030 ENOG4108JU5 Magnesium and cobalt efflux protein H0E72_RS06040 ENOG4105C9A Phoh family H0E72_RS06050 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H0E72_RS06090 ENOG4105CAQ asparagine synthetase H0E72_RS06095 ENOG4105D4U had-superfamily hydrolase, subfamily iia H0E72_RS06100 ENOG4105E2R ROK family H0E72_RS06105 ENOG4105CE4 GlcNAc 6-P deacetylase H0E72_RS06115 ENOG4105CI1 PTS System H0E72_RS06130 ENOG4105GX6 (LipO)protein H0E72_RS06135 ENOG41090R7 Ferric uptake H0E72_RS06145 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) H0E72_RS06150 ENOG4105NNH LexA regulated protein H0E72_RS06155 ENOG4105EV9 Alpha Beta Hydrolase H0E72_RS06160 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) H0E72_RS06165 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 H0E72_RS06180 ENOG4105D5Q Arginine ornithine antiporter H0E72_RS06185 ENOG4105CXN decarboxylase H0E72_RS06195 ENOG4105EEX Two component transcriptional regulator (Winged helix family H0E72_RS06200 ENOG4105C08 Histidine kinase H0E72_RS06225 ENOG4105XIQ Protein of unknown function (DUF2517) H0E72_RS06230 ENOG4107SEY Conserved Protein H0E72_RS06235 ENOG4105CVP deoxyribo-dipyrimidine photolyase H0E72_RS06240 ENOG4105DUX Transporter H0E72_RS06245 ENOG4107QNR UPF0135 protein H0E72_RS06250 ENOG4105P4J Allophanate hydrolase, subunit 1 H0E72_RS06255 ENOG4107R7A Allophanate hydrolase subunit 2 H0E72_RS06270 ENOG4108KK1 membrane protein AbrB duplication H0E72_RS06280 ENOG4105BZN citrate synthase H0E72_RS06290 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit H0E72_RS06295 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein H0E72_RS06300 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) H0E72_RS06305 ENOG4105E33 succinate dehydrogenase H0E72_RS06310 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 H0E72_RS06315 ENOG4105C7S Dehydrogenase H0E72_RS06325 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha H0E72_RS06330 ENOG4105ETT transcriptional Regulator, LysR family H0E72_RS06335 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase H0E72_RS06340 ENOG4107GFK fumarate H0E72_RS06365 ENOG4105DJI Methylaspartate mutase, E subunit H0E72_RS06375 ENOG4107WFU Glutamate mutase subunit sigma H0E72_RS06390 ENOG4105C4M (Ubiquinol oxidase) subunit I H0E72_RS06395 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H0E72_RS06405 ENOG4105KJB cyd operon protein YbgE H0E72_RS06410 ENOG4107YD3 Thioesterase H0E72_RS06415 ENOG4105E02 MotA TolQ exbB proton channel H0E72_RS06425 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA H0E72_RS06435 ENOG4105KCK Peptidoglycan-associated lipoprotein H0E72_RS06440 ENOG4105UFD tol-pal system protein YbgF H0E72_RS06485 ENOG4106Z1T Nicotinamide Mononucleotide Transporter H0E72_RS06495 ENOG4105JND homeobox protein H0E72_RS06500 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H0E72_RS06510 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) H0E72_RS06520 ENOG4105F0Z galactose-1-phosphate uridylyltransferase H0E72_RS06525 ENOG4105CMR udp-glucose 4-epimerase H0E72_RS06530 ENOG4105DKW ABC transporter H0E72_RS06535 ENOG4105F4R Transcriptional regulator mode H0E72_RS06545 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein H0E72_RS06550 ENOG4105E0C molybdate abc transporter H0E72_RS06560 ENOG4108K4B hydrolase H0E72_RS06570 ENOG4105F04 LysR family Transcriptional regulator H0E72_RS06575 ENOG4105C7F AcnD-accessory protein PrpF H0E72_RS06580 ENOG4107QPK )-transporter H0E72_RS06585 ENOG4107QM5 aconitate hydratase H0E72_RS06590 ENOG4105NBR Pectinesterase H0E72_RS06595 ENOG4108V1U phospholipid-binding protein H0E72_RS06600 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) H0E72_RS06615 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) H0E72_RS06620 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H0E72_RS06630 ENOG4105CHW UPF0052 protein H0E72_RS06640 ENOG4108RIR Molybdenum cofactor biosynthesis protein H0E72_RS06650 ENOG4105M00 molybdopterin converting factor, subunit 1 H0E72_RS06655 ENOG4108ZAF Molybdopterin H0E72_RS06660 ENOG4105HFZ Membrane H0E72_RS06665 ENOG410733J conserved inner membrane protein H0E72_RS06670 ENOG4107UXM Membrane H0E72_RS06675 ENOG4105DZQ phospholipase D Transphosphatidylase H0E72_RS06680 ENOG4105X23 Endonuclease Exonuclease phosphatase H0E72_RS06685 ENOG4105I9U inner membrane protein ybhQ H0E72_RS06690 ENOG4107QWP ABC-2 type transporter H0E72_RS06695 ENOG4107QWP ABC-2 type transporter H0E72_RS06700 ENOG4105CJ1 ABC, transporter H0E72_RS06710 ENOG4107MVR Transcriptional regulator H0E72_RS06715 ENOG4105C1J atp-dependent rna helicase H0E72_RS06730 ENOG4105DVT helicase H0E72_RS06735 ENOG4108MTB glycosyl transferase family H0E72_RS06740 ENOG4105DG4 malate L-lactate dehydrogenase H0E72_RS06745 ENOG4105VR4 UPF0379 protein ybiJ H0E72_RS06750 ENOG4105KSC Transcriptional regulator, TraR DksA family H0E72_RS06765 ENOG4105ZY9 UPF0379 protein ybiM H0E72_RS06775 ENOG4105D8X mechanosensitive ion channel H0E72_RS06780 ENOG4105CDA abc transporter atp-binding protein H0E72_RS06785 ENOG4105E5Q amino acid AbC transporter H0E72_RS06790 ENOG4107R0W ABC transporter H0E72_RS06800 ENOG4107AQZ Membrane H0E72_RS06810 ENOG4108T1M outer membrane protein x H0E72_RS06815 ENOG4108I6E Sulfatase H0E72_RS06825 ENOG4105KST dependent repressor H0E72_RS06830 ENOG4105F4P )-transporter H0E72_RS06835 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H0E72_RS06840 ENOG4105C5H ABC transporter H0E72_RS06845 ENOG41072TH Protein of unknown function (DUF1479) H0E72_RS06850 ENOG4108HCJ Hydrolase H0E72_RS06860 ENOG4105F1A Pyruvate formate-lyase H0E72_RS06865 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H0E72_RS06870 ENOG4105D06 uba thif-type nad fad binding protein H0E72_RS06875 ENOG4105CVM Molybdenum cofactor synthesis domain protein H0E72_RS06880 ENOG4105D44 asparaginase H0E72_RS06885 ENOG4108JQ6 ABC transporter H0E72_RS06890 ENOG4105DEF Extracellular solute-binding protein, family 5 H0E72_RS06905 ENOG4105BZU Histidine kinase H0E72_RS06910 ENOG41064RH membrane protein YliF H0E72_RS06930 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway H0E72_RS06935 ENOG4105D8V Glucose sorbosone dehydrogenase H0E72_RS06940 ENOG4108TGY Glutathione S-transferase H0E72_RS06945 ENOG4105DZ1 carboxypeptidase H0E72_RS06950 ENOG4107FB0 transcriptional regulator DeoR family H0E72_RS06955 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase H0E72_RS06960 ENOG4107QF7 multi-drug H0E72_RS06970 ENOG4108HCJ Hydrolase H0E72_RS06975 ENOG4106UW1 Major Facilitator superfamily H0E72_RS06980 ENOG4108RFG Tetr family transcriptional regulator H0E72_RS06990 ENOG4105GWF inner membrane protein YbjM H0E72_RS06995 ENOG41090BQ Glutaredoxin H0E72_RS07000 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress H0E72_RS07005 ENOG4108DBC nitroreductase H0E72_RS07015 ENOG4108RMJ sensory transduction regulator H0E72_RS07020 ENOG4107RUE extracellular solute-binding protein family 1 H0E72_RS07025 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0E72_RS07030 ENOG4105F38 ABC transporter, permease H0E72_RS07035 ENOG4105D38 putrescine abc transporter H0E72_RS07040 ENOG4105RBQ inner membrane protein ybjO H0E72_RS07050 ENOG4106TNF Periplasmic binding protein H0E72_RS07055 ENOG4105DMR ABC, transporter H0E72_RS07060 ENOG4105GBT ABC transporter H0E72_RS07065 ENOG4106PMH Extracellular solute-binding protein family 3 H0E72_RS07070 ENOG4105E5Z arginine transporter ATP-binding subunit H0E72_RS07075 ENOG41064MM (LipO)protein H0E72_RS07090 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase H0E72_RS07095 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase H0E72_RS07100 ENOG4105CGD Nad-dependent epimerase dehydratase H0E72_RS07105 ENOG4105C5W Aldolase H0E72_RS07110 ENOG4105C7K acetolactate synthase H0E72_RS07115 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H0E72_RS07125 ENOG4105DWU Membrane H0E72_RS07130 ENOG4105EQR Transposase IS116 IS110 IS902 H0E72_RS07140 ENOG4105ETP RND efflux system, outer membrane lipoprotein H0E72_RS07145 ENOG4105H9W Short-chain dehydrogenase reductase Sdr H0E72_RS07150 ENOG4105KHU inner membrane protein YohD H0E72_RS07155 ENOG41069YE inner membrane protein yohC H0E72_RS07160 ENOG41061WM D-Alanyl-D-Alanine H0E72_RS07165 ENOG4105CXG d-lactate dehydrogenase H0E72_RS07170 ENOG4107QK4 glycoside hydrolase, family 3 domain protein H0E72_RS07175 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system H0E72_RS07180 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component H0E72_RS07185 ENOG4108IJ8 ABC transporter H0E72_RS07190 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component H0E72_RS07200 ENOG4108XDN Transcriptional regulator H0E72_RS07205 ENOG4108HRK Histidine kinase H0E72_RS07210 ENOG4108NEV two component transcriptional regulator, LytTR family H0E72_RS07215 ENOG4108W15 Protein of unknown function (DUF1456) H0E72_RS07220 ENOG4108YCW (LipO)protein H0E72_RS07225 ENOG410903U zinc ion binding H0E72_RS07230 ENOG4105DEG Vwa containing coxe family protein H0E72_RS07235 ENOG4105RD5 H0E72_RS07240 ENOG4105KKX ATPase associated with various cellular activities aaa_5 H0E72_RS07250 ENOG4108KDT Molybdate metabolism regulator H0E72_RS07255 ENOG4108KDT Molybdate metabolism regulator H0E72_RS07265 ENOG4105D1F ATP-binding protein H0E72_RS07270 ENOG41067AK Protein of unknown function (DUF2574) H0E72_RS07275 ENOG41063W2 Fimbrial protein H0E72_RS07280 ENOG4108MQF Chaperone H0E72_RS07285 ENOG4105CW0 outer membrane usher protein H0E72_RS07290 ENOG410662B Type-1 fimbrial protein H0E72_RS07295 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly H0E72_RS07400 ENOG4105CAR Terminase, large subunit H0E72_RS07415 ENOG4105DWF phosphomethylpyrimidine kinase H0E72_RS07420 ENOG4108UQ1 hydrolase, family 25 H0E72_RS07425 ENOG4105FDP GntR family transcriptional regulator H0E72_RS07430 ENOG4108TFM Kinase, PfkB family H0E72_RS07435 ENOG4108KD5 ADP-ribosylation crystallin J1 H0E72_RS07440 ENOG4105EAA nucleoside H0E72_RS07445 ENOG4105EIE fructose-bisphosphate aldolase H0E72_RS07460 ENOG4105F2I Transposase H0E72_RS07480 ENOG41076Z6 Uncharacterized protein yegR H0E72_RS07485 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0E72_RS07530 ENOG4105VZ1 Replication Protein H0E72_RS07540 ENOG4105ED4 portal protein H0E72_RS07685 ENOG4105ZTC transcriptional activator, Ogr delta H0E72_RS07690 ENOG4105CFP Peptidase U32 H0E72_RS07700 ENOG4105X54 addiction module antidote protein H0E72_RS07705 ENOG4105KWI UPF0339 protein H0E72_RS07710 ENOG4105E3W Two component transcriptional regulator (Winged helix family H0E72_RS07715 ENOG4105EB3 Histidine kinase H0E72_RS07750 ENOG4108M24 von Willebrand factor, type A H0E72_RS07755 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase H0E72_RS07760 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) H0E72_RS07765 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding H0E72_RS07770 ENOG4105R8A Heat shock protein H0E72_RS07775 ENOG4105D03 DNA-3-methyladenine glycosylase II H0E72_RS07780 ENOG4105BZU Histidine kinase H0E72_RS07785 ENOG4105DBI uridine monophosphokinase H0E72_RS07795 ENOG4108GAE asmA family H0E72_RS07810 ENOG4105EE5 Membrane protein terC H0E72_RS07820 ENOG4105DAY polysaccharide export protein H0E72_RS07825 ENOG4105KJF protein tyrosine phosphatase H0E72_RS07830 ENOG4105D75 Capsular exopolysaccharide family H0E72_RS07835 ENOG41090RK glycosyl transferase H0E72_RS07840 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB H0E72_RS07845 ENOG4107RXY Glycosyl transferase H0E72_RS07850 ENOG4108NYJ Colanic acid H0E72_RS07855 ENOG4105ECJ Glycosyl Transferase H0E72_RS07860 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF H0E72_RS07865 ENOG4105C0K Gdp-mannose 4,6-dehydratase H0E72_RS07870 ENOG4105C30 Nad-dependent epimerase dehydratase H0E72_RS07875 ENOG4105FGF GDP-mannose mannosyl hydrolase H0E72_RS07880 ENOG4106CD9 glycosyl transferase group 1 H0E72_RS07885 ENOG4105CJT Mannose-1-phosphate guanylyltransferase H0E72_RS07890 ENOG4107QKV phosphomannomutase H0E72_RS07895 ENOG4105D3Q Sugar transferase H0E72_RS07900 ENOG4105PSV Polysaccharide Biosynthesis Protein H0E72_RS07905 ENOG4105C74 pyruvyl transferase H0E72_RS07910 ENOG4107T8Q Glycosyl transferase (Group 1 H0E72_RS07915 ENOG4105G1A colanic acid biosynthesis protein H0E72_RS07920 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H0E72_RS07925 ENOG4105C1B dTDP-glucose 4-6-dehydratase H0E72_RS07930 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase H0E72_RS07940 ENOG410650X lipopolysaccharide core region biosynthetic process H0E72_RS07960 ENOG4105D7W serine acetyltransferase H0E72_RS07970 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) H0E72_RS07975 ENOG4105C6Y Udp-glucose 6-dehydrogenase H0E72_RS07985 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase H0E72_RS08000 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) H0E72_RS08005 ENOG4105ECC imidazole-glycerol-phosphate dehydratase H0E72_RS08010 ENOG4105CIH Imidazole acetol-phosphate transaminase H0E72_RS08015 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) H0E72_RS08030 ENOG4105VTW prevent-host-death family H0E72_RS08035 ENOG4105KRQ Addiction module toxin, Txe YoeB family H0E72_RS08040 ENOG4107SRH Nad-dependent epimerase dehydratase H0E72_RS08045 ENOG4105EQ1 Transcriptional regulator H0E72_RS08055 ENOG4105CUB amino acid H0E72_RS08060 ENOG4105CUC YeeE YedE family protein H0E72_RS08070 ENOG4105CJB Exodeoxyribonuclease I H0E72_RS08075 ENOG4105DZ1 carboxypeptidase H0E72_RS08085 ENOG4105DR8 Membrane H0E72_RS08120 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles H0E72_RS08130 ENOG4108YGG dna repair protein H0E72_RS08135 ENOG4105MFG Antirestriction protein H0E72_RS08140 ENOG4106H6R UPF0380 protein H0E72_RS08160 ENOG4108YIV H0E72_RS08165 ENOG4108F5E vimentin H0E72_RS08235 ENOG41080QX K07048 phosphotriesterase-related protein H0E72_RS08265 ENOG4108YZT Adenosylcobinamide kinase H0E72_RS08270 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) H0E72_RS08275 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) H0E72_RS08280 ENOG4108PXI ErfK YbiS YcfS YnhG H0E72_RS08290 ENOG4106P55 Transcriptional regulator H0E72_RS08295 ENOG4107R11 Transcriptional regulator H0E72_RS08305 ENOG4105UQX Mate efflux family protein H0E72_RS08315 ENOG4105CDY transcriptional regulatory protein H0E72_RS08320 ENOG4105FYV Amp nucleosidase H0E72_RS08325 ENOG4105CSH Transporter H0E72_RS08340 ENOG4105TNG K13735 adhesin invasin H0E72_RS08345 ENOG4107ZSV Receptor H0E72_RS08350 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase H0E72_RS08370 ENOG4105C0W non-ribosomal peptide synthetase H0E72_RS08385 ENOG4105BZ1 (ABC) transporter H0E72_RS08390 ENOG4105EYM Major Facilitator superfamily H0E72_RS08430 ENOG41076J9 exonuclease VIII H0E72_RS08435 ENOG4106G8A Qin prophage H0E72_RS08450 ENOG4107712 H0E72_RS08465 ENOG41087BU transcriptional repressor DicA H0E72_RS08535 ENOG4108MXB Protein of unknown function (DUF968) H0E72_RS08540 ENOG4105KSK (crossover) junction endodeoxyribonuclease H0E72_RS08545 ENOG4105HRS Antitermination protein H0E72_RS08565 ENOG4105QFS Lysis protein S homolog from lambdoid prophage H0E72_RS08615 ENOG4105EFC phage portal protein HK97 family H0E72_RS08700 ENOG4108X9F tail fiber protein H0E72_RS08720 ENOG4108MEK Metal-binding protein YodA H0E72_RS08735 ENOG4105VT2 5-hydroxyisourate hydrolase H0E72_RS08740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family H0E72_RS08745 ENOG4107ZY3 Histidine kinase H0E72_RS08765 ENOG4105DVF Cytosine-specific methyltransferase H0E72_RS08770 ENOG41090BB DNA mismatch endonuclease (vsr) H0E72_RS08775 ENOG4105FDR Membrane H0E72_RS08780 ENOG4105CKW Inner membrane protein yedI H0E72_RS08785 ENOG4105VNZ cytoplasmic protein H0E72_RS08800 ENOG4105YX3 cellular response to acidity H0E72_RS08810 ENOG4107TKS colanic acid capsular biosynthesis activation protein A H0E72_RS08815 ENOG4105D19 Role in flagellar biosynthesis (By similarity) H0E72_RS08825 ENOG4105CN7 Flagellar biosynthetic protein FliP H0E72_RS08830 ENOG4105K0P flagellar biosynthesis protein H0E72_RS08835 ENOG4105DD5 Flagellar motor switch protein H0E72_RS08840 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H0E72_RS08845 ENOG4107ZI8 flagellar basal body-associated protein flil H0E72_RS08850 ENOG4105WF4 Flagellar hook-length control protein H0E72_RS08855 ENOG4105GSA Flagellar export protein flij H0E72_RS08860 ENOG4108JIR Flagellum-specific ATP synthase H0E72_RS08865 ENOG41090PJ Flagellar assembly protein H0E72_RS08870 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) H0E72_RS08875 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) H0E72_RS08885 ENOG410814C multidrug resistance protein H0E72_RS08890 ENOG4108V1U phospholipid-binding protein H0E72_RS08895 ENOG4108UQN AraC family transcriptional regulator H0E72_RS08900 ENOG4108RS6 transposase H0E72_RS08905 ENOG4105D7V transposase H0E72_RS08910 ENOG4108RAV Conserved protein H0E72_RS08920 ENOG41066VF YeeE YedE family protein H0E72_RS08925 ENOG4108W9D (LipO)protein H0E72_RS08930 ENOG4105E5K Alpha-amylase H0E72_RS08940 ENOG4105MQ3 flagellar protein FliS H0E72_RS08945 ENOG4105DTS flagellar hook-associated H0E72_RS08950 ENOG4105I03 Flagellin H0E72_RS08955 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0E72_RS08960 ENOG4108M9K flagella biosynthesis protein FliZ H0E72_RS08965 ENOG4105EAB amino acid AbC transporter H0E72_RS08970 ENOG4105K6H D-cysteine desulfhydrase H0E72_RS08975 ENOG4105E5Q amino acid AbC transporter H0E72_RS08980 ENOG4105CDA abc transporter atp-binding protein H0E72_RS08985 ENOG4105VJY transcriptional regulator H0E72_RS08990 ENOG4105XVG cytoplasmic protein H0E72_RS09000 ENOG4105WH1 Two component transcriptional regulator luxr family H0E72_RS09030 ENOG4106RHG Yeca family H0E72_RS09035 ENOG4105E0U tyrosine-specific transport protein H0E72_RS09040 ENOG4105VVZ metal-binding protein H0E72_RS09045 ENOG41090A1 ferritin H0E72_RS09050 ENOG4105P23 (LipO)protein H0E72_RS09060 ENOG4105N4N Protein of unknown function (DUF2766) H0E72_RS09065 ENOG4108UEC Ferritin-like protein H0E72_RS09070 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator H0E72_RS09075 ENOG4105C2J ABC transporter H0E72_RS09080 ENOG4105CNN ABC, transporter H0E72_RS09085 ENOG4108K4C ec 3.1.3.12 H0E72_RS09095 ENOG4108VA4 Universal stress protein H0E72_RS09105 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region H0E72_RS09110 ENOG4107RD7 Flagellar Motor Protein, MotA H0E72_RS09115 ENOG4105ER2 Ompa motb domain protein H0E72_RS09120 ENOG4105CBS Chea signal transduction histidine kinase H0E72_RS09125 ENOG4108V3W Chemotaxis protein, CheW H0E72_RS09130 ENOG4105C8Q Methyl-accepting chemotaxis H0E72_RS09135 ENOG4105C8Q Methyl-accepting chemotaxis H0E72_RS09140 ENOG4105BZU Histidine kinase H0E72_RS09150 ENOG4108VYJ response regulator receiver protein H0E72_RS09155 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) H0E72_RS09160 ENOG4105D00 flagellar biosynthetic protein flhB H0E72_RS09165 ENOG4105D7B Flagellar biosynthesis protein flha H0E72_RS09170 ENOG4105W13 flagellar protein H0E72_RS09175 ENOG4105C75 arginyL-tRNA synthetase H0E72_RS09180 ENOG4106ZCM YecM protein H0E72_RS09190 ENOG4105CUW cytochrome C-TYPE protein H0E72_RS09195 ENOG4107QY8 reductase H0E72_RS09210 ENOG4105WJG Glutathione H0E72_RS09215 ENOG41081XQ Conserved Protein H0E72_RS09220 ENOG4105D3W isochorismatase H0E72_RS09230 ENOG4108TIT dATP pyrophosphohydrolase H0E72_RS09235 ENOG4105CDY transcriptional regulatory protein H0E72_RS09245 ENOG4107S01 Repressor protein MetJ H0E72_RS09265 ENOG4105FAV ABC, transporter H0E72_RS09275 ENOG4105NXV High-affinity zinc uptake system protein H0E72_RS09280 ENOG4105DR5 peptidase H0E72_RS09285 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase H0E72_RS09290 ENOG4105CA9 Pyruvate kinase H0E72_RS09295 ENOG4106KNT transcriptional regulator H0E72_RS09300 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase H0E72_RS09305 ENOG4105C01 Dihydroxy-acid dehydratase H0E72_RS09310 ENOG4108UHU Aldolase H0E72_RS09315 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR H0E72_RS09320 ENOG4105X2V dna damage-inducible protein H0E72_RS09330 ENOG4108Q2J Inner membrane protein YebE H0E72_RS09335 ENOG4105CUG Oligopeptidase b H0E72_RS09340 ENOG4105UMD exodeoxyribonuclease X H0E72_RS09345 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase H0E72_RS09350 ENOG4105MPK DNA polymerase III subunit theta H0E72_RS09355 ENOG4105FXM Copper resistance protein H0E72_RS09360 ENOG4108PNC copper resistance H0E72_RS09365 ENOG4105NKT exported protein H0E72_RS09370 ENOG4108R1E Serine threonine protein phosphatase 1 H0E72_RS09375 ENOG4105UVW uncharacterized protein yebW H0E72_RS09380 ENOG4105WT8 Protein of unknown function (DUF1480) H0E72_RS09390 ENOG4105DY2 Paraquat-inducible protein b H0E72_RS09395 ENOG4105H2K paraquat-inducible protein a H0E72_RS09400 ENOG4108ZGC gaf domain protein H0E72_RS09410 ENOG4105CN1 protease H0E72_RS09420 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0E72_RS09425 ENOG4105J4Q Transcriptional regulator H0E72_RS09430 ENOG4105TIK H0E72_RS09440 ENOG4105Q3Y exported protein H0E72_RS09455 ENOG4105DHI Methyltransferase H0E72_RS09470 ENOG4105F3R pts system mannose fructose sorbose family iid H0E72_RS09475 ENOG4105ETZ PTS System H0E72_RS09480 ENOG4105DAS pts system H0E72_RS09485 ENOG4105EE5 Membrane protein terC H0E72_RS09490 ENOG4107XTP (EAL) domain protein H0E72_RS09495 ENOG4105EJQ L-serine dehydratase H0E72_RS09505 ENOG4105CRQ synthase (Component I) H0E72_RS09515 ENOG4105V2F Uncharacterized protein yoac H0E72_RS09520 ENOG4105M4H endoribonuclease L-psp H0E72_RS09525 ENOG4105DVT helicase H0E72_RS09530 ENOG41072GX Peptidase M22 Glycoprotease H0E72_RS09535 ENOG4105Y4Z Outer Membrane Lipoprotein H0E72_RS09540 ENOG4105CEY Amp-dependent synthetase and ligase H0E72_RS09545 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) H0E72_RS09550 ENOG4105E3J oxidoreductase H0E72_RS09555 ENOG4105DVW rieske (2Fe-2S) H0E72_RS09560 ENOG4105C94 Transporter H0E72_RS09565 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) H0E72_RS09570 ENOG4105EJC lysr family transcriptional regulator H0E72_RS09580 ENOG4108YS1 cytoplasmic protein H0E72_RS09585 ENOG4105YP6 Domain of unknown function (DUF1869) H0E72_RS09590 ENOG4105Y3U Transglycosylase-associated protein H0E72_RS09600 ENOG4106G4W H0E72_RS09605 ENOG410620I Diguanylate cyclase H0E72_RS09610 ENOG4105UCG Domain of unknown function (DUF333) H0E72_RS09615 ENOG4105K78 MarR family Transcriptional regulator H0E72_RS09620 ENOG4105DJ2 Major Facilitator Superfamily H0E72_RS09625 ENOG4105R1U AraC Family Transcriptional Regulator H0E72_RS09640 ENOG4108KXH Ybak prolyl-tRNA synthetase associated H0E72_RS09645 ENOG4108KHP Diguanylate cyclase H0E72_RS09650 ENOG4106KTS Inner membrane protein yeaI H0E72_RS09660 ENOG4105CYN Serine protein kinase H0E72_RS09665 ENOG4105GNX MltA-interacting MipA family protein H0E72_RS09670 ENOG4105CV8 reductase H0E72_RS09675 ENOG4105DSB aldose 1-epimerase H0E72_RS09680 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H0E72_RS09690 ENOG4105VUT cytoplasmic protein H0E72_RS09695 ENOG4105CPQ Dehydrogenase H0E72_RS09700 ENOG4107TE1 transport protein H0E72_RS09705 ENOG4105CPQ Dehydrogenase H0E72_RS09710 ENOG4105D2N Aldolase H0E72_RS09715 ENOG4107UH8 sugar kinase H0E72_RS09720 ENOG4105CPC Aldo Keto reductase H0E72_RS09725 ENOG4105E98 transcriptional regulator DeoR family H0E72_RS09730 ENOG4108KUU Inner membrane metabolite transport protein ydjE H0E72_RS09735 ENOG4108RWI nicotinamidase H0E72_RS09740 ENOG4105HDK L-asparaginase H0E72_RS09745 ENOG4105D07 Signal peptide peptidase, SppA H0E72_RS09750 ENOG41069NU Nitroreductase H0E72_RS09755 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) H0E72_RS09760 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H0E72_RS09765 ENOG4105D82 Glutamate dehydrogenase H0E72_RS09770 ENOG4105MTM Protein of unknown function (DUF1496) H0E72_RS09775 ENOG4105M6F mutator MutT protein H0E72_RS09780 ENOG4108T9J Cdp-alcohol phosphatidyltransferase H0E72_RS09785 ENOG4107RM6 sulfurtransferase H0E72_RS09790 ENOG4108VGW abc transporter atp-binding protein H0E72_RS09795 ENOG4105CXZ ABC transporter, permease H0E72_RS09800 ENOG4105VNH ABC transporter solute-binding protein H0E72_RS09805 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H0E72_RS09810 ENOG4108N5C SNARE associated Golgi protein-related protein H0E72_RS09815 ENOG4108KCW iron-sulfur cluster binding H0E72_RS09820 ENOG4108RSN SNARE associated Golgi H0E72_RS09825 ENOG4105CGK Exodeoxyribonuclease III H0E72_RS09855 ENOG4108SPG Periplasmic Protein H0E72_RS09865 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) H0E72_RS09875 ENOG4105KKI DNA-binding transcriptional activator OsmE H0E72_RS09880 ENOG4105VZJ PTS System H0E72_RS09885 ENOG4105CK1 PTS System H0E72_RS09890 ENOG4105VCP PTS System H0E72_RS09895 ENOG4105EZV Transcriptional regulator H0E72_RS09900 ENOG4105F8D glycoside hydrolase family 4 H0E72_RS09910 ENOG4105CH6 catalase H0E72_RS09925 ENOG4108ETY sodium dicarboxylate symporter H0E72_RS09930 ENOG4107K5X Membrane-bound metal-dependent hydrolase H0E72_RS09935 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 H0E72_RS09940 ENOG4107PN8 YfeABCD locus regulator H0E72_RS09950 ENOG4105P10 Uncharacterized protein ydiZ H0E72_RS09955 ENOG4105DE4 1-phosphofructokinase H0E72_RS09960 ENOG4108NE3 Salt-induced outer membrane protein H0E72_RS09980 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) H0E72_RS09985 ENOG41082NX 50s ribosomal protein l35 H0E72_RS10150 ENOG4105ED4 portal protein H0E72_RS10220 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0E72_RS10235 ENOG4108V06 Glutathione peroxidase H0E72_RS10245 ENOG4108QBX (LipO)protein H0E72_RS10250 ENOG4108TC0 Diguanylate phosphodiesterase H0E72_RS10265 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H0E72_RS10275 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) H0E72_RS10280 ENOG4107QPK )-transporter H0E72_RS10285 ENOG4105C5I Dehydrogenase H0E72_RS10295 ENOG41061TZ Short-chain dehydrogenase reductase Sdr H0E72_RS10300 ENOG4105CEY Amp-dependent synthetase and ligase H0E72_RS10305 ENOG41090P5 ferredoxin-like protein H0E72_RS10310 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase H0E72_RS10315 ENOG4105C10 Electron transfer flavoprotein H0E72_RS10320 ENOG4105CV7 Electron transfer flavoprotein H0E72_RS10325 ENOG4105W4W Transcriptional regulator H0E72_RS10330 ENOG4105C1G acyl-Coa dehydrogenase H0E72_RS10335 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) H0E72_RS10350 ENOG4105EMV Major Facilitator H0E72_RS10355 ENOG4105EMV Major Facilitator H0E72_RS10360 ENOG4105SUA Ydil protein H0E72_RS10370 ENOG4105IPI Membrane H0E72_RS10375 ENOG4105CQB FAD linked oxidase domain protein H0E72_RS10380 ENOG4105KA0 thioesterase Superfamily protein H0E72_RS10385 ENOG410671Z uncharacterized protein ydiH H0E72_RS10390 ENOG4108Z4V iron-sulfur cluster assembly H0E72_RS10395 ENOG4105DIW FeS assembly protein SUFB H0E72_RS10400 ENOG4105C3K feS assembly ATPase SufC H0E72_RS10405 ENOG4105JRK feS assembly protein SufD H0E72_RS10430 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H0E72_RS10435 ENOG4105KMX major outer membrane lipoprotein H0E72_RS10440 ENOG4105CA9 Pyruvate kinase H0E72_RS10445 ENOG4105RFR Protein of unknown function (DUF2767) H0E72_RS10450 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein H0E72_RS10455 ENOG4105WE2 aldehyde ferredoxin oxidoreductase H0E72_RS10460 ENOG4105JVW H0E72_RS10465 ENOG4108393 oxidoreductase Fe-S subunit H0E72_RS10470 ENOG4108NWD Cytochrome H0E72_RS10475 ENOG4108Y7C Conserved Protein H0E72_RS10485 ENOG4105N0V mono-oxygenase ydhR H0E72_RS10510 ENOG4108R6K riboflavin synthase, subunit alpha H0E72_RS10515 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase H0E72_RS10520 ENOG4105CZQ inner membrane transport protein YdhC H0E72_RS10525 ENOG4105F52 Transcriptional regulator H0E72_RS10540 ENOG4105F27 Major Facilitator H0E72_RS10545 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H0E72_RS10550 ENOG4105K4H Nlp p60 protein H0E72_RS10555 ENOG4105M2J Glutaredoxin H0E72_RS10560 ENOG4107QRT dEAD DEAH box helicase H0E72_RS10570 ENOG4108UYE Lactoylglutathione lyase H0E72_RS10575 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0E72_RS10580 ENOG4108WUH Transcriptional regulator, TetR family H0E72_RS10585 ENOG4105XZD Fe-S protein H0E72_RS10590 ENOG4107RGM aldo keto reductase H0E72_RS10595 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H0E72_RS10600 ENOG4105DSW Fusaric acid resistance protein H0E72_RS10605 ENOG4105Y49 secretion protein, HlyD family H0E72_RS10620 ENOG4108XTF Outer Membrane Lipoprotein H0E72_RS10630 ENOG410642K Lysozyme inhibitor H0E72_RS10645 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) H0E72_RS10650 ENOG4108K3A Glutathione S-transferase H0E72_RS10655 ENOG4105DUX Transporter H0E72_RS10660 ENOG4105CSM endonuclease III H0E72_RS10670 ENOG4108UQQ Electron transport complex H0E72_RS10695 ENOG4105M9B inner membrane protein ydgK H0E72_RS10700 ENOG4105QZ5 OriC-binding nucleoid-associated protein H0E72_RS10705 ENOG4106C6R beta-lactam resistance protein H0E72_RS10710 ENOG4105D9R oxidoreductase H0E72_RS10720 ENOG4105C87 Aminotransferase class I and II H0E72_RS10725 ENOG4105CI1 PTS System H0E72_RS10730 ENOG4107P2S Transcriptional regulator H0E72_RS10735 ENOG4107ZQV short-chain dehydrogenase reductase H0E72_RS10740 ENOG4105XEA Tetr family transcriptional regulator H0E72_RS10745 ENOG4105CNT hydrolase family 2 H0E72_RS10750 ENOG4105CT4 transporter H0E72_RS10755 ENOG4108QNI outer membrane porin protein H0E72_RS10760 ENOG4106J39 exported protein H0E72_RS10765 ENOG4105EIP mannose-6-phosphate isomerase H0E72_RS10770 ENOG4107GFK fumarate H0E72_RS10775 ENOG4105C9Q fumarate hydratase class II H0E72_RS10785 ENOG4105JJR Histidine kinase H0E72_RS10790 ENOG4107EXC regulatoR H0E72_RS10795 ENOG4105RA2 Membrane H0E72_RS10805 ENOG4105D5Q Arginine ornithine antiporter H0E72_RS10810 ENOG4105C5D exported protein H0E72_RS10815 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H0E72_RS10820 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) H0E72_RS10825 ENOG4105DSF transport protein H0E72_RS10840 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap H0E72_RS10855 ENOG4105D94 Major Facilitator Superfamily H0E72_RS10860 ENOG4106NZI LysR family Transcriptional regulator H0E72_RS10865 ENOG4105DAG ROK family H0E72_RS10870 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) H0E72_RS10880 ENOG4108NEM leader-binding protein dmsD H0E72_RS10885 ENOG4107KGK dmso reductase anchor subunit H0E72_RS10890 ENOG4105QAX Iron-sulfur H0E72_RS10900 ENOG4107QY8 reductase H0E72_RS10905 ENOG4105KBG Protein of unknown function (DUF1161) H0E72_RS10915 ENOG4108MK9 spermidine N(1)-acetyltransferase H0E72_RS10930 ENOG4105CXK mandelate racemase muconate lactonizing H0E72_RS10935 ENOG4105CPQ Dehydrogenase H0E72_RS10945 ENOG4107R08 Integrase H0E72_RS10960 ENOG4106G8A Qin prophage H0E72_RS10980 ENOG41087BU transcriptional repressor DicA H0E72_RS11020 ENOG4105WI6 cell killing protein encoded within cryptic prophage H0E72_RS11035 ENOG4108MXB Protein of unknown function (DUF968) H0E72_RS11040 ENOG4105HRS Antitermination protein H0E72_RS11050 ENOG4107SEY Conserved Protein H0E72_RS11055 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions H0E72_RS11060 ENOG4105QFS Lysis protein S homolog from lambdoid prophage H0E72_RS11085 ENOG41064WM Uncharacterized protein YcgX H0E72_RS11110 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) H0E72_RS11185 ENOG4108X9F tail fiber protein H0E72_RS11210 ENOG4105MN3 Resolvase H0E72_RS11215 ENOG4105W3V DNA-binding, transcriptional regulator H0E72_RS11230 ENOG4105DEI Mannitol dehydrogenase H0E72_RS11235 ENOG41061EV selenium-binding protein YdfZ H0E72_RS11240 ENOG4107XBN GntR Family Transcriptional Regulator H0E72_RS11245 ENOG4105EMU Dehydrogenase H0E72_RS11250 ENOG4105DGW oligopeptidase A H0E72_RS11255 ENOG4108YDI single-species biofilm formation on inanimate substrate H0E72_RS11260 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria H0E72_RS11270 ENOG4105E5W Transporter H0E72_RS11275 ENOG4108594 Permease of the drug metabolite transporter H0E72_RS11280 ENOG4105FDP GntR family transcriptional regulator H0E72_RS11290 ENOG4105CK1 PTS System H0E72_RS11295 ENOG4105VCP PTS System H0E72_RS11305 ENOG4105CS2 ec 3.2.1.21 H0E72_RS11310 ENOG4106DNR multiple antibiotic resistance protein H0E72_RS11315 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF H0E72_RS11320 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes H0E72_RS11340 ENOG4105F2I Transposase H0E72_RS11350 ENOG4105EGI Transcriptional regulator H0E72_RS11355 ENOG4105C26 Dehydrogenase H0E72_RS11360 ENOG4105CSV Glutaminase H0E72_RS11365 ENOG4105M0C cytoplasmic protein H0E72_RS11370 ENOG4105BZU Histidine kinase H0E72_RS11380 ENOG4105FFC UPF0187 protein H0E72_RS11390 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound H0E72_RS11445 ENOG4108RQP Major type 1 subunit fimbrin H0E72_RS11470 ENOG4108WDE Fimbrial protein H0E72_RS11475 ENOG4106318 fimbrial-like protein YdeR H0E72_RS11480 ENOG4106PIH fimbrial-like protein ydeQ H0E72_RS11485 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit H0E72_RS11500 ENOG4105ENH Sulfatase H0E72_RS11505 ENOG4105C4X radical SAM domain protein H0E72_RS11515 ENOG4105CQ0 ABC transporter H0E72_RS11520 ENOG4105PE1 Receptor H0E72_RS11525 ENOG4107RAN Peptidase, M16 H0E72_RS11530 ENOG4105CVK Glutamate decarboxylase H0E72_RS11535 ENOG4105E5D amino acid H0E72_RS11540 ENOG4105F32 YngK protein H0E72_RS11555 ENOG4105BZU Histidine kinase H0E72_RS11560 ENOG4108UQS dipeptidase H0E72_RS11565 ENOG4105DEF Extracellular solute-binding protein, family 5 H0E72_RS11570 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H0E72_RS11575 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H0E72_RS11580 ENOG4105C3U ABC transporter H0E72_RS11585 ENOG4107H6U ABC transporter H0E72_RS11590 ENOG4108Z9K Osmotically inducible protein H0E72_RS11595 ENOG4105TPS biofilm-dependent modulation protein H0E72_RS11600 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein H0E72_RS11610 ENOG4105DQ4 alcohol dehydrogenase H0E72_RS11615 ENOG41084S7 Plasmid maintenance system antidote protein H0E72_RS11620 ENOG4108MG3 formate dehydrogenase H0E72_RS11625 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0E72_RS11635 ENOG4105RPH Inner membrane protein YddG H0E72_RS11645 ENOG4108UI3 Leucine Rich repeat H0E72_RS11650 ENOG4108UI3 Leucine Rich repeat H0E72_RS11655 ENOG4107QND Nitrite extrusion protein H0E72_RS11660 ENOG4105CRU nitrate reductase, alpha subunit H0E72_RS11665 ENOG4108IUE nitrate reductase beta subunit H0E72_RS11670 ENOG4108NZN Respiratory nitrate reductase 2 delta chain H0E72_RS11675 ENOG4105D0D Nitrate reductase 2, gamma subunit H0E72_RS11680 ENOG4105JAB phenazine biosynthesis protein, phzf family H0E72_RS11685 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase H0E72_RS11690 ENOG4108MEJ flavin reductase domain protein H0E72_RS11700 ENOG4105EUZ Beta-lactamase domain protein H0E72_RS11710 ENOG4108N27 Glutathione S-transferase H0E72_RS11715 ENOG4105C85 amino acid H0E72_RS11720 ENOG4108NS2 receptor H0E72_RS11725 ENOG4105CHB tonB-dependent Receptor H0E72_RS11730 ENOG4108WYP Transcriptional regulator H0E72_RS11735 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein H0E72_RS11740 ENOG4108Z7F N-acetyltransferase H0E72_RS11745 ENOG4108T9Y Inner membrane protein ydcZ H0E72_RS11750 ENOG4105R71 cytoplasmic protein H0E72_RS11755 ENOG410654E Membrane H0E72_RS11770 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component H0E72_RS11775 ENOG4105D81 ABC transporter, permease H0E72_RS11780 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0E72_RS11785 ENOG4107TYH extracellular solute-binding protein family 1 H0E72_RS11790 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family H0E72_RS11795 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin H0E72_RS11805 ENOG4105RR0 Protein of unknown function (DUF2554) H0E72_RS11810 ENOG4105CFP Peptidase U32 H0E72_RS11815 ENOG4108JCI Transcriptional regulator H0E72_RS11825 ENOG4105VNT transposase (IS4 family) protein H0E72_RS11835 ENOG4108KKZ (LipO)protein H0E72_RS11840 ENOG41088CC tellurite resistance protein tehB H0E72_RS11845 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein H0E72_RS11850 ENOG4107WE3 acetyltransferase YdcK H0E72_RS11855 ENOG4108Z9I -acetyltransferase H0E72_RS11860 ENOG4105Z2P Protein of unknown function (DUF465) H0E72_RS11870 ENOG4105E32 cytoplasmic protein H0E72_RS11875 ENOG4105DDW LysR family Transcriptional regulator H0E72_RS11880 ENOG4105C8Q Methyl-accepting chemotaxis H0E72_RS11885 ENOG4107NK6 Hok/gef family H0E72_RS11890 ENOG4105UPP uncharacterized protein ydcA H0E72_RS11895 ENOG4105CPW cytochrome b561 H0E72_RS11900 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase H0E72_RS11905 ENOG4105C26 Dehydrogenase H0E72_RS11910 ENOG4107DB1 DUF218 domain H0E72_RS11915 ENOG4105CQ7 ATP-dependent helicase H0E72_RS11925 ENOG41077RS Phosphatase H0E72_RS11930 ENOG4105E8V Alpha Beta Hydrolase Fold protein H0E72_RS11935 ENOG4108HPI phosphatidate Cytidylyltransferase H0E72_RS11940 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase H0E72_RS11950 ENOG4107S5I aldo keto reductase H0E72_RS11955 ENOG4107EF2 surface-exposed virulence protein H0E72_RS11960 ENOG4105WXT Conserved Protein H0E72_RS11965 ENOG410689M (LipO)protein H0E72_RS11970 ENOG4107H52 Dicarboxylate transport H0E72_RS11975 ENOG4105C5I Dehydrogenase H0E72_RS11980 ENOG41090X5 Heat shock protein hslJ H0E72_RS11985 ENOG4105IKK cytoplasmic protein H0E72_RS11990 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) H0E72_RS11995 ENOG4105FCK Membrane H0E72_RS12000 ENOG4108RW8 Universal stress protein F H0E72_RS12010 ENOG4105C1J atp-dependent rna helicase H0E72_RS12020 ENOG4105BZU Histidine kinase H0E72_RS12025 ENOG4108DG9 Smr protein MutS2 H0E72_RS12030 ENOG4106KR7 LysR family Transcriptional regulator H0E72_RS12035 ENOG4105CH2 amidohydrolase H0E72_RS12040 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B H0E72_RS12045 ENOG4105CFC Transporter H0E72_RS12050 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H0E72_RS12055 ENOG4105DS0 Transcriptional regulator, Crp Fnr family H0E72_RS12060 ENOG4105Q9Y Universal stress protein H0E72_RS12065 ENOG4105S5I Membrane H0E72_RS12070 ENOG4105D64 Mechanosensitive ion channel H0E72_RS12075 ENOG4107QSI ABC, transporter H0E72_RS12080 ENOG4105EQ2 LysR family Transcriptional regulator H0E72_RS12085 ENOG4105ENX hydrolase H0E72_RS12100 ENOG4105KXI murein peptide amidase A H0E72_RS12105 ENOG4107S8C mandelate racemase muconate lactonizing H0E72_RS12110 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) H0E72_RS12115 ENOG4108JU8 Transcriptional regulator H0E72_RS12125 ENOG4105CM6 amino acid regulated cytosolic protein H0E72_RS12130 ENOG4105FKQ transcriptional regulator H0E72_RS12135 ENOG4107EFV Outer membrane protein G H0E72_RS12140 ENOG4108IJ9 (ABC) transporter H0E72_RS12145 ENOG4107URF beta-phospho-glucomutase H0E72_RS12150 ENOG4105C71 hydrolase family 65, central catalytic H0E72_RS12155 ENOG4105CK5 oxidoreductase H0E72_RS12160 ENOG4107TYA transient receptor potential locus H0E72_RS12165 ENOG4107RRD Dehydrogenase H0E72_RS12170 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component H0E72_RS12175 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component H0E72_RS12180 ENOG4105WEM extracellular solute-binding protein H0E72_RS12185 ENOG4107QW3 Sucrose phosphorylase H0E72_RS12190 ENOG4105K8Z Phage shock protein H0E72_RS12195 ENOG4105NNG Peripheral inner membrane phage-shock protein H0E72_RS12200 ENOG4105FM1 phage shock protein C H0E72_RS12205 ENOG4105YYT phage shock protein B H0E72_RS12210 ENOG41087YS Phage shock protein A H0E72_RS12215 ENOG4105E51 psp operon transcriptional activator H0E72_RS12220 ENOG4108JPW Aminotransferase H0E72_RS12225 ENOG4105CJP fad dependent oxidoreductase H0E72_RS12230 ENOG4105C26 Dehydrogenase H0E72_RS12235 ENOG4107VRI Transcriptional regulator H0E72_RS12240 ENOG4108Z86 Glutamine amidotransferase H0E72_RS12245 ENOG4105CFQ glutamine synthetase H0E72_RS12255 ENOG4105CUB amino acid H0E72_RS12260 ENOG4105N0E Protein of unknown function (DUF2543) H0E72_RS12265 ENOG4108HIY periplasmic H0E72_RS12270 ENOG4108I5W peptide transport system, permease protein H0E72_RS12275 ENOG4108EU3 peptide transport system, permease H0E72_RS12280 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein H0E72_RS12285 ENOG4108JQ2 peptide transport system atp-binding protein H0E72_RS12290 ENOG4105C2C drug resistance transporter, Bcr CflA H0E72_RS12295 ENOG4105ENJ RND efflux system, outer membrane lipoprotein H0E72_RS12300 ENOG4105BZS acriflavin resistance protein H0E72_RS12305 ENOG4105C1P efflux transporter, rnd family, mfp subunit H0E72_RS12310 ENOG41067SE Tetr family transcriptional regulator H0E72_RS12315 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH H0E72_RS12320 ENOG4105Q4T oxidoreductase H0E72_RS12335 ENOG4105BZU Histidine kinase H0E72_RS12340 ENOG410643D UPF0509 protein H0E72_RS12345 ENOG4105N2W Transcriptional regulator H0E72_RS12355 ENOG4108ZJT translation initiation factor, Sui1 H0E72_RS12365 ENOG4105CFV Tetratricopeptide repeat protein H0E72_RS12370 ENOG4105Q4A inner membrane protein yciS H0E72_RS12375 ENOG4105EYK Phosphatidylglycerophosphatase B H0E72_RS12385 ENOG4107QM5 aconitate hydratase H0E72_RS12405 ENOG4107R11 Transcriptional regulator H0E72_RS12410 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H0E72_RS12415 ENOG4105RKX Protein of unknown function (DUF2498) H0E72_RS12420 ENOG4105ERU peptidase H0E72_RS12425 ENOG4105UBK short-chain dehydrogenase reductase H0E72_RS12430 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase H0E72_RS12445 ENOG4105FE9 pseudouridine synthase H0E72_RS12450 ENOG4105EG3 transmembrane signal peptide protein H0E72_RS12455 ENOG4107RTD sua5 ycio yrdc ywlc family protein H0E72_RS12460 ENOG4105DB7 PHP domain protein H0E72_RS12470 ENOG4105CRQ synthase (Component I) H0E72_RS12475 ENOG4108EFP Anthranilate synthase component II H0E72_RS12480 ENOG4105DK0 Indole-3-glycerol phosphate synthase H0E72_RS12500 ENOG4108Z9Z response to DNA damage stimulus H0E72_RS12525 ENOG4108WF3 methyltransferase H0E72_RS12530 ENOG4105UZW Tail fiber assembly protein H0E72_RS12535 ENOG4108X9F tail fiber protein H0E72_RS12610 ENOG4105IM0 capsid protein H0E72_RS12635 ENOG4105UZW Tail fiber assembly protein H0E72_RS12645 ENOG4106YSC H0E72_RS12685 ENOG4105QFS Lysis protein S homolog from lambdoid prophage H0E72_RS12710 ENOG4105HGD Antitermination protein H0E72_RS12715 ENOG4105KSK (crossover) junction endodeoxyribonuclease H0E72_RS12720 ENOG4108MXB Protein of unknown function (DUF968) H0E72_RS12790 ENOG4106G8A Qin prophage H0E72_RS12805 ENOG4108I1J Integrase H0E72_RS12810 ENOG4105EIF outer membrane protein W H0E72_RS12830 ENOG4105NAU thioesterase Superfamily protein H0E72_RS12835 ENOG410822N TonB family H0E72_RS12840 ENOG4105K9H YciI-like protein H0E72_RS12860 ENOG4105Y50 Virulence Protein H0E72_RS12875 ENOG4107SVH Potassium channel protein H0E72_RS12895 ENOG4108JQ7 (ABC) transporter H0E72_RS12900 ENOG4105C3U ABC transporter H0E72_RS12905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H0E72_RS12910 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H0E72_RS12915 ENOG4108J59 Extracellular solute-binding protein, family 5 H0E72_RS12925 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein H0E72_RS12930 ENOG4105C0A alcohol dehydrogenase H0E72_RS12935 ENOG4107104 thymidine kinase H0E72_RS12940 ENOG4108SAU DNA-binding protein H-ns H0E72_RS12945 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase H0E72_RS12950 ENOG4105I93 response regulator H0E72_RS12955 ENOG4105D78 K07001 NTE family protein H0E72_RS12960 ENOG4105K5B UPF0225 protein H0E72_RS12965 ENOG4105CIY formyltetrahydrofolate deformylase H0E72_RS12985 ENOG41076YT nitrate reductase, gamma subunit H0E72_RS12990 ENOG4105R3A Nitrate reductase H0E72_RS12995 ENOG4108IUE nitrate reductase beta subunit H0E72_RS13000 ENOG4105CRU nitrate reductase, alpha subunit H0E72_RS13005 ENOG4105DQQ Major facilitator superfamily MFS_1 H0E72_RS13010 ENOG4105BZU Histidine kinase H0E72_RS13015 ENOG4105WH1 Two component transcriptional regulator luxr family H0E72_RS13020 ENOG4105ID0 Putative invasin H0E72_RS13025 ENOG41090EX DsrE family H0E72_RS13030 ENOG4108NH8 Cation transport protein H0E72_RS13035 ENOG4105WS7 Cation transport regulator H0E72_RS13040 ENOG4105EWV Sodium calcium exchanger membrane region H0E72_RS13060 ENOG41063JG Transcriptional regulator H0E72_RS13065 ENOG4108YY7 Invasion gene expression up-regulator SirB H0E72_RS13070 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) H0E72_RS13095 ENOG4105C5T Phosphoribosyl pyrophosphate synthase H0E72_RS13100 ENOG4105CHH sulfate transporter H0E72_RS13105 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria H0E72_RS13115 ENOG4105C3G gtp-binding protein H0E72_RS13125 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family H0E72_RS13130 ENOG4105CMT Dihydroxyacetone kinase H0E72_RS13135 ENOG4108UTZ Dihydroxyacetone kinase H0E72_RS13140 ENOG4105VDH Dihydroxyacetone kinase H0E72_RS13150 ENOG4105S10 periplasmic binding protein H0E72_RS13155 ENOG4105EHG Permease protein H0E72_RS13160 ENOG4105E0A ABC, transporter H0E72_RS13165 ENOG4108BSC Methyltransferase H0E72_RS13170 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase H0E72_RS13185 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) H0E72_RS13195 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A H0E72_RS13215 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) H0E72_RS13225 ENOG4105ED1 spovr family H0E72_RS13240 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) H0E72_RS13245 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) H0E72_RS13250 ENOG4105KT5 UmuD protein H0E72_RS13255 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells H0E72_RS13265 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase H0E72_RS13275 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium H0E72_RS13280 ENOG4105S66 prophage protein H0E72_RS13290 ENOG4107QMS site-determining protein H0E72_RS13320 ENOG410658X H0E72_RS13335 ENOG4105BZU Histidine kinase H0E72_RS13340 ENOG410738I uncharacterized protein ymgC H0E72_RS13350 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB H0E72_RS13355 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component H0E72_RS13360 ENOG4105BZU Histidine kinase H0E72_RS13365 ENOG4108XDN Transcriptional regulator H0E72_RS13370 ENOG41064WM Uncharacterized protein YcgX H0E72_RS13390 ENOG4108HMX isocitrate dehydrogenase (NADP) H0E72_RS13415 ENOG4107QTF adenylosuccinate lyase H0E72_RS13420 ENOG4105XJC Two component transcriptional regulator (Winged helix family H0E72_RS13425 ENOG4105IFJ Histidine kinase H0E72_RS13430 ENOG4105EZE Cupin 4 family protein H0E72_RS13440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0E72_RS13450 ENOG4105D38 putrescine abc transporter H0E72_RS13455 ENOG4107RUE extracellular solute-binding protein family 1 H0E72_RS13470 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) H0E72_RS13480 ENOG4105D60 lipoprotein releasing system transmembrane protein H0E72_RS13485 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) H0E72_RS13490 ENOG4105D60 lipoprotein releasing system transmembrane protein H0E72_RS13495 ENOG4105IQC Inner membrane protein YcfT H0E72_RS13500 ENOG4108JA2 transcriptioN-repair coupling factor H0E72_RS13505 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein H0E72_RS13510 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction H0E72_RS13515 ENOG4108IND Tetr family transcriptional regulator H0E72_RS13520 ENOG4107MBR 17 kDa surface antigen H0E72_RS13525 ENOG4105CEP NADH dehydrogenase H0E72_RS13545 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) H0E72_RS13550 ENOG41090DQ Lipoprotein H0E72_RS13555 ENOG4105K59 histidine triad (HIT) protein H0E72_RS13560 ENOG4105CNM Receptor H0E72_RS13565 ENOG4105CI1 PTS System H0E72_RS13570 ENOG4105F8V Hydrolase, tatD family H0E72_RS13575 ENOG4107QRG dna polymerase iii H0E72_RS13585 ENOG4105HHA aminodeoxychorismate lyase H0E72_RS13590 ENOG4105YAZ 4-amino-4-deoxychorismate lyase H0E72_RS13595 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H0E72_RS13600 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H0E72_RS13605 ENOG4105CHR reductase H0E72_RS13610 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase H0E72_RS13630 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein H0E72_RS13635 ENOG4108UHJ MAF-like protein H0E72_RS13640 ENOG4105EI2 Pseudouridine synthase H0E72_RS13645 ENOG4107QQB Ribonuclease E H0E72_RS13660 ENOG4105DTJ flagellar hook-associated protein H0E72_RS13665 ENOG4105E1Q flagellar hook-associated protein H0E72_RS13670 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj H0E72_RS13675 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) H0E72_RS13685 ENOG4105CGA flagellar basal-body rod protein FlgG H0E72_RS13690 ENOG4108KPB Flagellar basal-body rod protein FlgF H0E72_RS13695 ENOG4105BZE flagellar hook protein, FlgE H0E72_RS13700 ENOG4105W00 Flagellar hook capping protein H0E72_RS13705 ENOG4108ZC9 flagellar basal-body rod protein flgc H0E72_RS13710 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) H0E72_RS13715 ENOG4105CKS Flagella basal body P-ring formation protein flgA H0E72_RS13720 ENOG4105M9M anti-sigma28 factor FlgM H0E72_RS13725 ENOG4105QVD Flagella synthesis protein FlgN H0E72_RS13730 ENOG4105CJR Integral membrane protein (MviN H0E72_RS13735 ENOG4105EP9 oxidoreductase H0E72_RS13745 ENOG4105D9U N-acetyltransferase H0E72_RS13755 ENOG4105E9S glutaredoxin 2 H0E72_RS13760 ENOG4105F3T (LipO)protein H0E72_RS13770 ENOG4105MEA DNA damage-inducible protein i H0E72_RS13775 ENOG4105PVA Biofilm formation regulatory protein BssS H0E72_RS13785 ENOG4106974 biofilm formation H0E72_RS13790 ENOG4105DS1 cytochrome b561 H0E72_RS13795 ENOG4108YYC ycei family H0E72_RS13805 ENOG4105D1S lipid A biosynthesis H0E72_RS13815 ENOG4108W47 Acidic protein msyB H0E72_RS13820 ENOG4105NAC (LipO)protein H0E72_RS13825 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) H0E72_RS13840 ENOG4107RZC phospholipase d H0E72_RS13845 ENOG4108UVJ appr-1-p processing domain protein H0E72_RS13860 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin H0E72_RS13865 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers H0E72_RS13870 ENOG41086KC Transcriptional regulator H0E72_RS13875 ENOG4108XDW curli assembly protein CsgE H0E72_RS13880 ENOG4108WYR Curli production assembly transport component, CsgF H0E72_RS13885 ENOG4105P8Q Curli production assembly transport component CsgG H0E72_RS13890 ENOG4108UQ5 membrane protein YcdZ H0E72_RS13895 ENOG4107XHZ cytoplasmic chaperone TorD family protein H0E72_RS13920 ENOG4105D5M phosphate starvation-inducible protein H0E72_RS13925 ENOG4105DBE peroxidase H0E72_RS13935 ENOG4105EKT )-iron permease H0E72_RS13940 ENOG4105CK7 Sodium proline symporter H0E72_RS13950 ENOG4105C26 Dehydrogenase H0E72_RS13955 ENOG4108R86 Transcriptional regulator H0E72_RS13990 ENOG4105C2W permease H0E72_RS13995 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 H0E72_RS14005 ENOG4105XH3 H0E72_RS14010 ENOG4105D6F Phosphatase H0E72_RS14035 ENOG4107QY8 reductase H0E72_RS14040 ENOG4105CUW cytochrome C-TYPE protein H0E72_RS14045 ENOG4106WF9 DNA-binding transcriptional regulator TorR H0E72_RS14050 ENOG4108SV3 Tmao reductase system periplasmic protein tort H0E72_RS14055 ENOG4105BZU Histidine kinase H0E72_RS14060 ENOG4105HEE Binding Domain protein H0E72_RS14065 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation H0E72_RS14080 ENOG4105VEQ Cold shock protein H0E72_RS14085 ENOG41060EU Cold shock-like protein H0E72_RS14090 ENOG4105D6F Phosphatase H0E72_RS14100 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii H0E72_RS14105 ENOG4105C4M (Ubiquinol oxidase) subunit I H0E72_RS14110 ENOG4105MVP hydrogenase-1 operon protein HyaF H0E72_RS14115 ENOG4108VXY Hydrogenase-1 operon protein HyaE H0E72_RS14120 ENOG4108USZ hydrogenase H0E72_RS14125 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit H0E72_RS14130 ENOG4105DPX Hydrogenase, large subunit H0E72_RS14135 ENOG4105E3S small subunit H0E72_RS14145 ENOG4108MN8 Membrane H0E72_RS14150 ENOG4108Z0T Part of a sulfur-relay system (By similarity) H0E72_RS14155 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 H0E72_RS14170 ENOG4105K4P CoA-binding domain protein H0E72_RS14185 ENOG41088T4 Helicase IV H0E72_RS14190 ENOG410901E Membrane H0E72_RS14195 ENOG4105EM2 membrane H0E72_RS14200 ENOG4108RZ1 DNA transformation protein H0E72_RS14210 ENOG4105UYK outer membrane protein a H0E72_RS14220 ENOG4105DAN ATP-dependent protease H0E72_RS14230 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) H0E72_RS14235 ENOG4108Q2G (LipO)protein H0E72_RS14240 ENOG4105DY2 Paraquat-inducible protein b H0E72_RS14245 ENOG4105F1S paraquat-inducible protein a H0E72_RS14250 ENOG4105C5H ABC transporter H0E72_RS14260 ENOG4105QVC MOSC domain-containing protein H0E72_RS14265 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) H0E72_RS14275 ENOG4106PH7 chaperone H0E72_RS14280 ENOG4105MX3 Fimbrial H0E72_RS14285 ENOG4105Q7J Fimbrial H0E72_RS14290 ENOG4108MDY Fimbrial H0E72_RS14295 ENOG4105CW0 outer membrane usher protein H0E72_RS14300 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae H0E72_RS14305 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon H0E72_RS14310 ENOG4108UZX fmn reductase H0E72_RS14315 ENOG4105GVF (ABC) transporter H0E72_RS14325 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component H0E72_RS14330 ENOG4105E2Y ABC, transporter H0E72_RS14335 ENOG4105CD8 aminopeptidase N H0E72_RS14350 ENOG4105FCK Membrane H0E72_RS14355 ENOG4105CGF Aromatic amino acid aminotransferase H0E72_RS14360 ENOG4105C5X domain protein H0E72_RS14365 ENOG4105EAQ (twin-arginine translocation) pathway signal H0E72_RS14370 ENOG4105DIT ErfK YbiS YcfS YnhG family protein H0E72_RS14380 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) H0E72_RS14390 ENOG4106371 Methyltransferase H0E72_RS14395 ENOG4107S90 membrAne H0E72_RS14400 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups H0E72_RS14415 ENOG4105T0Z Conserved Protein H0E72_RS14425 ENOG4105BZ1 (ABC) transporter H0E72_RS14440 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) H0E72_RS14450 ENOG4108K0D peptidase, M48 H0E72_RS14455 ENOG4105VNT transposase (IS4 family) protein H0E72_RS14470 ENOG4107VMU Membrane H0E72_RS14475 ENOG4105DDY UPF0142 protein ycaO H0E72_RS14480 ENOG4105TMB Formate nitrite transporter H0E72_RS14485 ENOG4105C6N Formate acetyltransferase H0E72_RS14490 ENOG4105F1A Pyruvate formate-lyase H0E72_RS14500 ENOG4105E5D amino acid H0E72_RS14510 ENOG4105CHJ isochorismatase hydrolase H0E72_RS14520 ENOG4105QAX Iron-sulfur H0E72_RS14525 ENOG4107QY8 reductase H0E72_RS14535 ENOG4105D1H recombination factor protein RarA H0E72_RS14545 ENOG4105CNU cell division protein FtsK H0E72_RS14555 ENOG4105C3M thioredoxin reductase H0E72_RS14560 ENOG4108JJ9 ABC, transporter H0E72_RS14565 ENOG4108JJ8 (ABC) transporter H0E72_RS14575 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) H0E72_RS14585 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0E72_RS14595 ENOG4105VEQ Cold shock protein H0E72_RS14605 ENOG4105DJY efflux transporter, rnd family, mfp subunit H0E72_RS14610 ENOG4108MJ5 VirK protein H0E72_RS14615 ENOG4105CPB ATP-dependent endonuclease of the OLD family H0E72_RS14620 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) H0E72_RS14625 ENOG4105EQR Transposase IS116 IS110 IS902 H0E72_RS14630 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) H0E72_RS14640 ENOG41067MG lrgb family H0E72_RS14650 ENOG4107GZ4 SanA protein H0E72_RS14655 ENOG4105Y9N Membrane H0E72_RS14660 ENOG4105BZ8 glutamate synthase H0E72_RS14665 ENOG4107SJI Dehydrogenase H0E72_RS14670 ENOG4108HWV )-transporter H0E72_RS14675 ENOG4105C2J ABC transporter H0E72_RS14680 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator H0E72_RS14685 ENOG41060NJ transcriptional regulator H0E72_RS14690 ENOG4105DHF Membrane H0E72_RS14705 ENOG4105D05 Receptor H0E72_RS14710 ENOG4108IQI permease H0E72_RS14715 ENOG4105DUM transcriptional regulator, lysR family H0E72_RS14720 ENOG4105HMI Membrane H0E72_RS14730 ENOG4105DD7 kinase (PfkB family H0E72_RS14735 ENOG4105D9N nucleoside H0E72_RS14745 ENOG4108Y4K DNA-binding transcriptional activator H0E72_RS14750 ENOG4105D9N nucleoside H0E72_RS14755 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) H0E72_RS14760 ENOG4105DD7 kinase (PfkB family H0E72_RS14765 ENOG4105DM4 PTS System H0E72_RS14770 ENOG4105DE4 1-phosphofructokinase H0E72_RS14775 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein H0E72_RS14780 ENOG4105S8Q sugar efflux transporter H0E72_RS14785 ENOG4105KRS Proteinase inhibitor H0E72_RS14795 ENOG4105DEI Mannitol dehydrogenase H0E72_RS14800 ENOG4105CKI cobalamin synthesis protein H0E72_RS14805 ENOG41076MN Phosphoesterase, PA-phosphatase related H0E72_RS14810 ENOG4107TT5 NLP P60 protein H0E72_RS14815 ENOG4105CXC rtn protein H0E72_RS14820 ENOG4105E43 Extracellular solute-binding protein, family 5 H0E72_RS14825 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component H0E72_RS14830 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component H0E72_RS14835 ENOG4108JQ5 ABC transporter H0E72_RS14840 ENOG4105HG6 H0E72_RS14845 ENOG4105C2C drug resistance transporter, Bcr CflA H0E72_RS14850 ENOG4105I08 Pseudouridine synthase H0E72_RS14855 ENOG4105CFI type iii restriction protein res subunit H0E72_RS14875 ENOG4105E68 Sulfatase H0E72_RS14885 ENOG4108MGN ATP-binding component of a transport system H0E72_RS14890 ENOG4105WH1 Two component transcriptional regulator luxr family H0E72_RS14895 ENOG4105KWW Biogenesis protein H0E72_RS14900 ENOG4107QX9 Thiol disulfide interChange protein H0E72_RS14905 ENOG4105DA4 cytochrome c-type biogenesis protein H0E72_RS14915 ENOG4105X3C heme exporter protein H0E72_RS14920 ENOG41060IM Heme exporter protein H0E72_RS14925 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) H0E72_RS14930 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) H0E72_RS14935 ENOG4105CUW cytochrome C-TYPE protein H0E72_RS14940 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) H0E72_RS14945 ENOG4105GXZ Ferredoxin-type protein NapH H0E72_RS14950 ENOG4108BGM Quinol dehydrogenase periplasmic component H0E72_RS14960 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase H0E72_RS14965 ENOG4108ZNS ferredoxin-type protein NapF H0E72_RS14985 ENOG4105IBP Cyclic peptide transporter H0E72_RS14990 ENOG4105CF1 Alkylated DNA repair protein H0E72_RS14995 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) H0E72_RS15000 ENOG4105CJ2 (LipO)protein H0E72_RS15005 ENOG4105FCK Membrane H0E72_RS15010 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC H0E72_RS15015 ENOG41068CG regulatoR H0E72_RS15020 ENOG4105BZU Histidine kinase H0E72_RS15025 ENOG4105BZU Histidine kinase H0E72_RS15030 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H0E72_RS15035 ENOG4107QP7 CoA-transferase subunit A H0E72_RS15040 ENOG4107QNJ CoA-transferase subunit B H0E72_RS15045 ENOG4105CRW Short chain fatty acid transporter H0E72_RS15050 ENOG4105CHU acetyl-coa acetyltransferase H0E72_RS15055 ENOG4105EDV vault protein H0E72_RS15060 ENOG41081SK signal peptide protein H0E72_RS15065 ENOG4107S52 alpha-2-macroglobulin domain protein H0E72_RS15070 ENOG4108QJJ Protein of unknown function (DUF1175) H0E72_RS15075 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) H0E72_RS15080 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0E72_RS15085 ENOG4105CXK mandelate racemase muconate lactonizing H0E72_RS15095 ENOG4105DRR Transcriptional regulator, GntR family H0E72_RS15105 ENOG4107GHC outer membrane autotransporter H0E72_RS15110 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0E72_RS15115 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0E72_RS15120 ENOG4105XPH Ferredoxin H0E72_RS15125 ENOG4105FQR PH-inducible protein involved in stress response H0E72_RS15130 ENOG4105CZM Major Facilitator H0E72_RS15135 ENOG4105GZI Transcriptional regulator H0E72_RS15140 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase H0E72_RS15145 ENOG4105CXY transporter H0E72_RS15150 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A H0E72_RS15160 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H0E72_RS15165 ENOG4105DNE Transposase H0E72_RS15180 ENOG4105CSP Major Facilitator Superfamily H0E72_RS15190 ENOG4107258 Transcriptional regulator H0E72_RS15200 ENOG4108UII YfaZ family H0E72_RS15250 ENOG4106GZG polymyxin resistance protein B H0E72_RS15255 ENOG4105CEY Amp-dependent synthetase and ligase H0E72_RS15265 ENOG4108IPT Naphthoate synthase H0E72_RS15280 ENOG4105E4F Isochorismate synthase H0E72_RS15285 ENOG4105TNS Conserved Protein H0E72_RS15290 ENOG4107YB6 acetyltransferase, (GNAT) family H0E72_RS15300 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is H0E72_RS15305 ENOG4105CP2 von willebrand factor, type a H0E72_RS15310 ENOG4107VAM peptidase, m28 H0E72_RS15315 ENOG4105GDX Domain of unknown function (DUF1877) H0E72_RS15325 ENOG4105C8S subunit m H0E72_RS15330 ENOG4105D65 subunit l H0E72_RS15340 ENOG4107UFS subunit j H0E72_RS15355 ENOG4108IEH NADH dehydrogenase subunit g H0E72_RS15360 ENOG4107QIZ NADH dehydrogenase H0E72_RS15365 ENOG4105GKE subunit e H0E72_RS15385 ENOG4107NQ8 LysR family Transcriptional regulator H0E72_RS15390 ENOG4105CHM Aminotransferase H0E72_RS15400 ENOG4107QWE )-transporter H0E72_RS15405 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 H0E72_RS15410 ENOG4105XWI UPF0304 protein H0E72_RS15420 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H0E72_RS15425 ENOG4105C6K Malic enzyme H0E72_RS15430 ENOG4105CSX c4-dicarboxylate anaerobic carrier H0E72_RS15435 ENOG4105PTV Nudix Hydrolase H0E72_RS15440 ENOG4108RE9 Phosphodiesterase H0E72_RS15445 ENOG4108SHQ Glutathione S-transferase H0E72_RS15450 ENOG4105CYM Glutathione S-transferase H0E72_RS15455 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase H0E72_RS15460 ENOG4105ECP epimerase H0E72_RS15465 ENOG4105DNE Transposase H0E72_RS15470 ENOG4108JEH abc transporter atp-binding protein H0E72_RS15475 ENOG4106YG3 ABC transporter H0E72_RS15480 ENOG4105DSP amino acid AbC transporter H0E72_RS15485 ENOG4105E89 ABC transporter H0E72_RS15490 ENOG4105E89 ABC transporter H0E72_RS15495 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H0E72_RS15500 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase H0E72_RS15505 ENOG4105E96 Colicin v production protein H0E72_RS15510 ENOG4108S3P Sporulation domain protein H0E72_RS15515 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase H0E72_RS15525 ENOG4105DQR SNARE associated Golgi H0E72_RS15535 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H0E72_RS15545 ENOG4106WZ1 flagella biosynthesis regulator H0E72_RS15550 ENOG4105F9N Major Facilitator Superfamily H0E72_RS15555 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) H0E72_RS15565 ENOG4105MH2 YfcL protein H0E72_RS15570 ENOG4108BPE -transporting atpase H0E72_RS15575 ENOG4105EJ9 Membrane H0E72_RS15585 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase H0E72_RS15590 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) H0E72_RS15615 ENOG4105US4 fimbrial-like protein yfcP H0E72_RS15620 ENOG4105UGQ Fimbrial H0E72_RS15625 ENOG4105NEV Fimbrial H0E72_RS15630 ENOG4108FZ9 Chaperone H0E72_RS15635 ENOG4106PG1 outer membrane usher protein H0E72_RS15645 ENOG4108BY2 phosphohistidine phosphatase H0E72_RS15660 ENOG4105KZW UPF0381 protein H0E72_RS15665 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation H0E72_RS15675 ENOG410903C (LipO)protein H0E72_RS15680 ENOG4105S64 Formate nitrite transporter H0E72_RS15705 ENOG4108W9T type 1 fimbriae regulatory protein H0E72_RS15710 ENOG4108W9T type 1 fimbriae regulatory protein H0E72_RS15715 ENOG4105W8I Transcriptional regulator H0E72_RS15730 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0E72_RS15735 ENOG4105CW7 secretion protein, HlyD family H0E72_RS15740 ENOG4108WQH regulatoR H0E72_RS15745 ENOG4105BZU Histidine kinase H0E72_RS15750 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F H0E72_RS15755 ENOG4108N2Y auxin Efflux H0E72_RS15760 ENOG4105CFN oxalyl-CoA decarboxylase H0E72_RS15770 ENOG4108V08 YfdX protein H0E72_RS15780 ENOG4105W9M Membrane H0E72_RS15785 ENOG4105D1S lipid A biosynthesis H0E72_RS15795 ENOG4105CHM Aminotransferase H0E72_RS15800 ENOG4108HRK Histidine kinase H0E72_RS15805 ENOG4105DY9 regulatoR H0E72_RS15810 ENOG4108CIP transcriptional regulator H0E72_RS15815 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H0E72_RS15820 ENOG4105CN9 Peptidase m42 family protein H0E72_RS15825 ENOG4105DC7 peptidase M24 H0E72_RS15830 ENOG410863U PTS System H0E72_RS15835 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) H0E72_RS15850 ENOG4109076 Conserved Protein H0E72_RS15860 ENOG4105D9N nucleoside H0E72_RS15865 ENOG4108KMM Diguanylate cyclase H0E72_RS15880 ENOG4105HZG regulatoR H0E72_RS15885 ENOG4105GXM Putative transcription regulator (DUF1323) H0E72_RS15925 ENOG4105CN8 Transcriptional regulator H0E72_RS15935 ENOG4105EAA nucleoside H0E72_RS15940 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) H0E72_RS15945 ENOG4108NFH Sugar hydrolase H0E72_RS15950 ENOG4108M0I Transcriptional regulator H0E72_RS15955 ENOG4105DHU Bile acid H0E72_RS15960 ENOG4105VRT cytoplasmic protein H0E72_RS15980 ENOG4105C6T cysteine synthase H0E72_RS15990 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) H0E72_RS15995 ENOG4105C5Y PTS System H0E72_RS16000 ENOG4105VNT transposase (IS4 family) protein H0E72_RS16010 ENOG4105M0Y H0E72_RS16015 ENOG4105C6T cysteine synthase H0E72_RS16020 ENOG4108IJ6 ABC transporter H0E72_RS16025 ENOG4105ECW sulfate abc transporter H0E72_RS16030 ENOG4108I5D sulfate abc transporter H0E72_RS16035 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein H0E72_RS16040 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr H0E72_RS16055 ENOG4105C5Y PTS System H0E72_RS16060 ENOG4107S1E Beta-lactamase H0E72_RS16065 ENOG4105EZR dyp-type peroxidase family protein H0E72_RS16070 ENOG4105E7K (LipO)protein H0E72_RS16075 ENOG4105QZU Inner membrane protein YfeZ H0E72_RS16085 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase H0E72_RS16095 ENOG4108K3Z AraC family transcriptional regulator H0E72_RS16100 ENOG4108X49 Ethanolamine utilization protein EutK H0E72_RS16105 ENOG4106D67 ethanolamine utilization protein H0E72_RS16115 ENOG4105CPD ethanolamine ammonia-lyase H0E72_RS16120 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase H0E72_RS16125 ENOG4105ENY Ethanolamine utilization protein eutH H0E72_RS16130 ENOG4105C0A alcohol dehydrogenase H0E72_RS16135 ENOG4107RWI ethanolamine utilization protein eutJ H0E72_RS16140 ENOG4108EKI Dehydrogenase H0E72_RS16145 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml H0E72_RS16150 ENOG4105KNY Microcompartments protein H0E72_RS16155 ENOG4107WUY phosphate acetyltransferase H0E72_RS16160 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase H0E72_RS16165 ENOG4105NDK ethanolamine utilization protein H0E72_RS16170 ENOG4106S4J ethanolamine utilization protein EutP H0E72_RS16175 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place H0E72_RS16180 ENOG4105C6K Malic enzyme H0E72_RS16185 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) H0E72_RS16190 ENOG4105CV1 Transketolase (EC 2.2.1.1) H0E72_RS16195 ENOG4108PVD exported protein H0E72_RS16205 ENOG4105BZ8 glutamate synthase H0E72_RS16210 ENOG4105BZU Histidine kinase H0E72_RS16215 ENOG4105BZS acriflavin resistance protein H0E72_RS16225 ENOG4105KUZ arsenate reductase H0E72_RS16240 ENOG4106KED esterase YpfH H0E72_RS16250 ENOG4105CGZ zinc metallopeptidase H0E72_RS16260 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H0E72_RS16270 ENOG4105RH4 Glycine cleavage system transcriptional repressor H0E72_RS16275 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H0E72_RS16280 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) H0E72_RS16285 ENOG4108JPZ Monovalent cation H antiporter subunit D H0E72_RS16290 ENOG4107TDF Formate hydrogenlyase subunit 4 H0E72_RS16295 ENOG4105D65 subunit l H0E72_RS16300 ENOG4107WQX hydrogenase 4 membrane subunit H0E72_RS16305 ENOG4108JPZ Monovalent cation H antiporter subunit D H0E72_RS16310 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0E72_RS16320 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit H0E72_RS16325 ENOG4105I6X formate hydrogenlyase maturation H0E72_RS16330 ENOG4108JUA Transcriptional regulator H0E72_RS16335 ENOG4105TMB Formate nitrite transporter H0E72_RS16340 ENOG4105C02 permease H0E72_RS16345 ENOG4105ERG peptidase m48, ste24p H0E72_RS16350 ENOG4105K89 arsenate reductase H0E72_RS16355 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) H0E72_RS16360 ENOG4105C2W permease H0E72_RS16375 ENOG4108V3E phosphoribosylglycinamide formyltransferase H0E72_RS16380 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) H0E72_RS16385 ENOG4105C9X ppx gppa phosphatase H0E72_RS16390 ENOG4105BZU Histidine kinase H0E72_RS16400 ENOG41062G3 Protein of unknown function (DUF2633) H0E72_RS16405 ENOG4108ZMA Outer membrane lipoprotein H0E72_RS16410 ENOG41066DY Membrane H0E72_RS16420 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) H0E72_RS16445 ENOG4105VPD cellular component movement H0E72_RS16460 ENOG4105N21 Membrane H0E72_RS16490 ENOG4108JQB penicillin-binding protein 1C H0E72_RS16495 ENOG4105DN3 alpha-2-macroglobulin domain protein H0E72_RS16500 ENOG4105KHC sulfurtransferase H0E72_RS16505 ENOG4105YYA enhanced serine sensitivity protein SseB H0E72_RS16515 ENOG4105WVQ Fe-S assembly protein IscX H0E72_RS16520 ENOG4108ZIT Ferredoxin, 2FE-2S H0E72_RS16540 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins H0E72_RS16560 ENOG4105ECY inositol monophosphatase H0E72_RS16565 ENOG4107XM9 (LipO)protein H0E72_RS16570 ENOG4108MN2 Stationary phase inducible protein CsiE H0E72_RS16575 ENOG4105D8G Major Facilitator superfamily H0E72_RS16580 ENOG4108W5M transcriptional regulator H0E72_RS16585 ENOG4105FUY alpha subunit H0E72_RS16610 ENOG4108SB3 DoxX Family H0E72_RS16615 ENOG4108ZKT aldose 1-epimerase H0E72_RS16620 ENOG4105CPQ Dehydrogenase H0E72_RS16625 ENOG4105CNN ABC, transporter H0E72_RS16630 ENOG4108F37 ATP-binding component of a transport system H0E72_RS16635 ENOG4105FCA ABC transporter periplasmic-binding protein YphF H0E72_RS16640 ENOG4107HQ7 repeat protein H0E72_RS16645 ENOG4108NZE NAGC-like transcriptional regulator H0E72_RS16655 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) H0E72_RS16665 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H0E72_RS16670 ENOG4108SKK alpha helix protein H0E72_RS16675 ENOG4107WP9 Histidine kinase H0E72_RS16680 ENOG4108ETH Formylglycinamide ribotide synthetase H0E72_RS16690 ENOG4108Z6B deaminase H0E72_RS16695 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB H0E72_RS16700 ENOG4106G6Q Transcriptional regulator H0E72_RS16705 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding H0E72_RS16720 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) H0E72_RS16740 ENOG4105C3F Signal peptidase i H0E72_RS16750 ENOG4105WMJ Positive regulator of sigma E, RseC MucC H0E72_RS16755 ENOG4105VQK sigma E regulatory protein, MucB RseB H0E72_RS16760 ENOG41069PW sigma-e factor negative regulatory protein H0E72_RS16765 ENOG4105EMN RNA polymerase sigma factor H0E72_RS16775 ENOG4108IYU L-aspartate oxidase H0E72_RS16785 ENOG4105C1J atp-dependent rna helicase H0E72_RS16790 ENOG41090KR LysR family transcriptional Regulator H0E72_RS16810 ENOG4105EIB trna rrna methyltransferase H0E72_RS16815 ENOG4105K63 Thioredoxin H0E72_RS16820 ENOG4106IUH DTW domain containing protein H0E72_RS16825 ENOG4105CD5 CoA-binding domain protein H0E72_RS16830 ENOG4105JIM Phosphatidylserine synthase H0E72_RS16835 ENOG4105T42 (LipO)protein H0E72_RS16840 ENOG4105CSH Transporter H0E72_RS16865 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit H0E72_RS16870 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase H0E72_RS16875 ENOG4105C34 Pseudouridine synthase H0E72_RS16880 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane H0E72_RS16885 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA H0E72_RS16895 ENOG4105CQC Prephenate dehydratase H0E72_RS16900 ENOG4105EHE chorismate mutase- prephenate dehydrogenase H0E72_RS16905 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) H0E72_RS16910 ENOG4105QP9 Protein of unknown function (DUF2799) H0E72_RS16915 ENOG4108WS1 H0E72_RS16920 ENOG4108KHX Diguanylate cyclase H0E72_RS16925 ENOG41090EK ompa motb domain protein H0E72_RS16950 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY H0E72_RS16955 ENOG4106KVJ cytochrome C assembly protein H0E72_RS16960 ENOG4108JU6 CBS domain protein H0E72_RS16980 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) H0E72_RS16985 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) H0E72_RS16995 ENOG4108Z1B Cyclase dehydrase H0E72_RS17010 ENOG4108MGN ATP-binding component of a transport system H0E72_RS17035 ENOG4105E54 alpha-amylase H0E72_RS17045 ENOG4105D5U fad dependent oxidoreductase H0E72_RS17050 ENOG4105C26 Dehydrogenase H0E72_RS17055 ENOG4108JPW Aminotransferase H0E72_RS17060 ENOG4105C85 amino acid H0E72_RS17065 ENOG4108PVQ transcriptional regulator H0E72_RS17070 ENOG4109066 lysm domain bon superfamily protein H0E72_RS17075 ENOG4105VPI YqaE family transport protein H0E72_RS17080 ENOG41080HT Transcriptional regulator, arsr family H0E72_RS17085 ENOG4108V62 Rhodanese domain protein H0E72_RS17090 ENOG4108X73 DNA- binding protein H0E72_RS17095 ENOG4108RNS Exports L-alanine (By similarity) H0E72_RS17100 ENOG4108WMJ Protein of unknown function (DUF2002) H0E72_RS17105 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) H0E72_RS17115 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) H0E72_RS17120 ENOG4105WAZ (Glutaredoxin-like protein) NrdH H0E72_RS17130 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0E72_RS17135 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) H0E72_RS17140 ENOG4108IJ7 Glycine betaine H0E72_RS17145 ENOG4108HQS Glycine betaine H0E72_RS17150 ENOG4105GIJ Glycine betaine H0E72_RS17160 ENOG4108UMN azlc family H0E72_RS17165 ENOG4105ZED uncharacterized protein ygaH H0E72_RS17170 ENOG4105NTK Transcriptional repressor Mpra H0E72_RS17175 ENOG4105CW7 secretion protein, HlyD family H0E72_RS17180 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0E72_RS17195 ENOG4105W39 Membrane H0E72_RS17200 ENOG4107VXZ Hydrolase H0E72_RS17230 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) H0E72_RS17250 ENOG4107TH8 cina domain protein H0E72_RS17255 ENOG4105CVE Lytic murein transglycosylase H0E72_RS17260 ENOG410787A Pts system, glucitol sorbitol-specific H0E72_RS17265 ENOG4105DZY Pts system, glucitol sorbitol-specific H0E72_RS17270 ENOG4105VI0 Pts system, glucitol sorbitol-specific H0E72_RS17275 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase H0E72_RS17280 ENOG4105J92 DNA-binding transcriptional activator GutM H0E72_RS17285 ENOG410804X Transcriptional regulator H0E72_RS17290 ENOG4105C2X Arabinose 5-phosphate isomerase H0E72_RS17310 ENOG4105C8H hydrogenase maturation protein Hypf H0E72_RS17315 ENOG4108RC0 Electron transport protein H0E72_RS17320 ENOG4105DDV Transcriptional regulator (LacI family H0E72_RS17325 ENOG4105C5Y PTS System H0E72_RS17330 ENOG4105CS2 ec 3.2.1.21 H0E72_RS17340 ENOG4108MG9 hydrogenase 3 maturation protease H0E72_RS17345 ENOG4105I6X formate hydrogenlyase maturation H0E72_RS17350 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit H0E72_RS17355 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit H0E72_RS17360 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) H0E72_RS17365 ENOG4107TDF Formate hydrogenlyase subunit 4 H0E72_RS17370 ENOG4107R30 NADH dehydrogenase H0E72_RS17375 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) H0E72_RS17380 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA H0E72_RS17385 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) H0E72_RS17390 ENOG4107RSS Hydrogenase accessory protein HypB H0E72_RS17395 ENOG41083WG hydrogenase assembly chaperone H0E72_RS17400 ENOG4105CQS hydrogenase expression formation protein HypD H0E72_RS17405 ENOG4105C45 hydrogenase expression formation protein (HypE) H0E72_RS17410 ENOG4108JUA Transcriptional regulator H0E72_RS17420 ENOG4105VXR cytoplasmic protein H0E72_RS17435 ENOG4105MEW serine threonine protein phosphatase H0E72_RS17440 ENOG4105KZM cytoplasmic protein H0E72_RS17445 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H0E72_RS17450 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase H0E72_RS17460 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0E72_RS17465 ENOG4108K5P (LipO)protein H0E72_RS17500 ENOG4105N0Z inner membrane protein ygbE H0E72_RS17515 ENOG4105C11 sulfate adenylyltransferase), subunit 2 H0E72_RS17520 ENOG4108MXK alkaline phosphatase isozyme conversion H0E72_RS17525 ENOG4105PWE CRISPR-associated protein cas2 H0E72_RS17530 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) H0E72_RS17540 ENOG4108VWQ crispr-associated protein H0E72_RS17545 ENOG41060M0 Crispr-associated protein, cse4 family H0E72_RS17555 ENOG4105CYR Crispr-associated protein, cse1 family H0E72_RS17560 ENOG4105DTT CRISPR-associated helicase, cas3 H0E72_RS17565 ENOG4107635 Hok Gef family protein H0E72_RS17585 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase H0E72_RS17590 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase H0E72_RS17595 ENOG4105WQV ferredoxin-like protein H0E72_RS17600 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator H0E72_RS17605 ENOG4105YBM electron transfer flavoprotein subunit ygcQ H0E72_RS17610 ENOG4106IKH Electron transfer flavoprotein H0E72_RS17615 ENOG4105C54 Major Facilitator superfamily H0E72_RS17620 ENOG4107R3A FAD linked oxidase domain protein H0E72_RS17625 ENOG4105CHR reductase H0E72_RS17630 ENOG4108ITV Inner membrane protein yqcE H0E72_RS17635 ENOG4108CWB sugar kinase ygcE H0E72_RS17660 ENOG4105WBN Transcriptional regulator (LacI family H0E72_RS17665 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) H0E72_RS17675 ENOG4105HA9 of methanol dehydrogenase type H0E72_RS17685 ENOG4105HA9 of methanol dehydrogenase type H0E72_RS17690 ENOG4105VNT transposase (IS4 family) protein H0E72_RS17705 ENOG4105DXN mazG family H0E72_RS17710 ENOG4105MZG transcriptional modulator of maze toxin, mazf H0E72_RS17715 ENOG4106A2Z transcriptional regulator antitoxin, MazE H0E72_RS17720 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H0E72_RS17730 ENOG4105BZU Histidine kinase H0E72_RS17735 ENOG4105EQX glucarate dehydratase H0E72_RS17740 ENOG4105EQX glucarate dehydratase H0E72_RS17745 ENOG4105DJB Major Facilitator Superfamily H0E72_RS17750 ENOG4105QDK Flavodoxin H0E72_RS17755 ENOG4105DR9 pseudouridine synthase H0E72_RS17760 ENOG4105WP7 tRNA pseudouridine synthase C H0E72_RS17775 ENOG4105EWT decarboxylase family H0E72_RS17780 ENOG4105C44 Serine transporter H0E72_RS17785 ENOG4105EJQ L-serine dehydratase H0E72_RS17795 ENOG4105C0A alcohol dehydrogenase H0E72_RS17800 ENOG4107W7X Aldolase H0E72_RS17805 ENOG4105EDR glucose galactose transporter H0E72_RS17815 ENOG4105CMG Carbohydrate kinase H0E72_RS17825 ENOG4107EDW L-fucose operon activator H0E72_RS17835 ENOG4105M08 Membrane H0E72_RS17840 ENOG4105ETT transcriptional Regulator, LysR family H0E72_RS17845 ENOG4105M5B (LipO)protein H0E72_RS17850 ENOG4105C9B Cysteine desulfurase H0E72_RS17855 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) H0E72_RS17860 ENOG4105CUZ uba thif-type nad fad binding protein H0E72_RS17865 ENOG4105CA3 membrane-bound lytic murein transglycosylase H0E72_RS17890 ENOG4105C2X Arabinose 5-phosphate isomerase H0E72_RS17895 ENOG4105C87 Aminotransferase class I and II H0E72_RS17900 ENOG4105CI1 PTS System H0E72_RS17910 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase H0E72_RS17915 ENOG4108EKC n-acetylglutamate synthase H0E72_RS17920 ENOG4107QYX exodeoxyribonuclease v alpha H0E72_RS17925 ENOG4107QKA exodeoxyribonuclease V beta H0E72_RS17930 ENOG4107QXK peptidase H0E72_RS17935 ENOG4105DSY exodeoxyribonuclease V, gamma H0E72_RS17940 ENOG4105RVB Prepilin peptidase dependent protein c H0E72_RS17945 ENOG4105SEN Protein of unknown function (DUF2509) H0E72_RS17950 ENOG4105JCS prepilin peptidase dependent protein H0E72_RS17955 ENOG4105IPU prepilin peptidase dependent protein A H0E72_RS17970 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase H0E72_RS17985 ENOG4105EE5 Membrane protein terC H0E72_RS17990 ENOG4105SUV lipoprotein YgdR H0E72_RS17995 ENOG4105CPC Aldo Keto reductase H0E72_RS18000 ENOG4107S74 Lysophospholipid transporter LplT H0E72_RS18010 ENOG41060NJ transcriptional regulator H0E72_RS18020 ENOG4105RQF LysR family Transcriptional regulator H0E72_RS18030 ENOG4107QNK )-transporter H0E72_RS18035 ENOG4105CHR reductase H0E72_RS18045 ENOG4105CHU acetyl-coa acetyltransferase H0E72_RS18050 ENOG4108MHD transport protein H0E72_RS18055 ENOG4105ISV protein with bipartite regulator domain H0E72_RS18060 ENOG4108TC1 Transcriptional regulator H0E72_RS18065 ENOG4105FV3 H0E72_RS18090 ENOG4108YAB Invasion protein H0E72_RS18150 ENOG4108M6W surface presentation of antigens protein SpaS H0E72_RS18155 ENOG4108M6W surface presentation of antigens protein SpaS H0E72_RS18160 ENOG4108TN6 type iii secretion H0E72_RS18165 ENOG4105U07 type iii secretion H0E72_RS18185 ENOG4108T88 H0E72_RS18195 ENOG4108K5P (LipO)protein H0E72_RS18200 ENOG4105C7W Xanthine dehydrogenase H0E72_RS18205 ENOG4108HR6 Dehydrogenase H0E72_RS18210 ENOG4108UTP (2Fe-2S)-binding domain protein H0E72_RS18215 ENOG4108JUB Transcriptional regulator H0E72_RS18220 ENOG4105IW6 Carbamoyltransferase H0E72_RS18225 ENOG4107RCH Diaminopropionate ammonia-lyase H0E72_RS18230 ENOG4107S4Y M20 DapE family protein YgeY H0E72_RS18240 ENOG4105C5B carbamate kinase H0E72_RS18245 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family H0E72_RS18250 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC H0E72_RS18255 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase H0E72_RS18260 ENOG4105BZ8 glutamate synthase H0E72_RS18265 ENOG4107UUR Chlorohydrolase aminohydrolase H0E72_RS18270 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase H0E72_RS18275 ENOG4105C7W Xanthine dehydrogenase H0E72_RS18280 ENOG4105C2W permease H0E72_RS18285 ENOG4107QUY Guanine deaminase H0E72_RS18290 ENOG4105C7N Xanthine uracil vitamin C permease H0E72_RS18295 ENOG4108R8B oxidoreductase Fe-S subunit H0E72_RS18300 ENOG4105BZ8 glutamate synthase H0E72_RS18305 ENOG4105C2W permease H0E72_RS18335 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) H0E72_RS18340 ENOG4105T95 Thiol disulfide interChange protein H0E72_RS18345 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0E72_RS18350 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) H0E72_RS18355 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB H0E72_RS18360 ENOG4105Y75 tpr repeat protein H0E72_RS18370 ENOG4108UT2 hemolysin iii H0E72_RS18380 ENOG4105CS2 ec 3.2.1.21 H0E72_RS18385 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H0E72_RS18410 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family H0E72_RS18415 ENOG4105D0A hydroxylase H0E72_RS18420 ENOG4107RAQ aminopeptidase H0E72_RS18440 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase H0E72_RS18455 ENOG4108JQ1 Dehydrogenase H0E72_RS18475 ENOG4105D5P Methylmalonyl-coA mutase H0E72_RS18480 ENOG4105DJT lAO AO transport system ATPase H0E72_RS18485 ENOG4108M7F enoyl-CoA hydratase isomerase H0E72_RS18490 ENOG4105CYC Transferase H0E72_RS18495 ENOG4105DEQ transcriptional regulator H0E72_RS18500 ENOG4105MPN Membrane H0E72_RS18505 ENOG4108ZUB Lysine exporter protein (Lyse ygga) H0E72_RS18510 ENOG4105D64 Mechanosensitive ion channel H0E72_RS18515 ENOG4105D2N Aldolase H0E72_RS18545 ENOG4108JJB ABC transporter H0E72_RS18550 ENOG4108JJB ABC transporter H0E72_RS18555 ENOG4107Z1W Fructose transport system kinase H0E72_RS18560 ENOG4108R4K DNA-binding, transcriptional regulator H0E72_RS18565 ENOG4108Q8A Fructose-1,6-bisphosphatase H0E72_RS18570 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein H0E72_RS18575 ENOG4105CTS PTS system mannitol-specific H0E72_RS18580 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia H0E72_RS18585 ENOG4105CV1 Transketolase (EC 2.2.1.1) H0E72_RS18590 ENOG4108K0D peptidase, M48 H0E72_RS18605 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) H0E72_RS18625 ENOG4107QNK )-transporter H0E72_RS18635 ENOG4105RWS endonuclease I H0E72_RS18640 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) H0E72_RS18645 ENOG4105D7Z glutathione synthase H0E72_RS18660 ENOG4105CZX twitching motility protein H0E72_RS18665 ENOG4105DFA alanine racemase domain protein H0E72_RS18670 ENOG4108VIA integral membrane protein H0E72_RS18680 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) H0E72_RS18685 ENOG4105CSA Coproporphyrinogen iii oxidase H0E72_RS18690 ENOG4106MH3 alpha helix chain H0E72_RS18695 ENOG4105HDK L-asparaginase H0E72_RS18700 ENOG4105K33 Periplasmic Protein H0E72_RS18705 ENOG41090ED Protein with unknown function (DUF469) H0E72_RS18715 ENOG4105CEN a g-specific adenine glycosylase H0E72_RS18730 ENOG4105EAA nucleoside H0E72_RS18735 ENOG4105CXN decarboxylase H0E72_RS18740 ENOG4108UQV Membrane H0E72_RS18770 ENOG41067TZ transcriptional regulator, MarR family H0E72_RS18780 ENOG4105D5Q Arginine ornithine antiporter H0E72_RS18785 ENOG4105CXN decarboxylase H0E72_RS18790 ENOG4105D5Q Arginine ornithine antiporter H0E72_RS18800 ENOG4105F2I Transposase H0E72_RS18805 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family H0E72_RS18840 ENOG4105F2I Transposase H0E72_RS18855 ENOG4105D5K Hemolysin activator protein H0E72_RS18880 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) H0E72_RS18885 ENOG4107RWI ethanolamine utilization protein eutJ H0E72_RS18895 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml H0E72_RS18910 ENOG4105KNY Microcompartments protein H0E72_RS18915 ENOG4105EHR propanediol utilization protein pduB H0E72_RS18920 ENOG4108EKI Dehydrogenase H0E72_RS18930 ENOG4107R7Y intracellular protease Pfpi family H0E72_RS18940 ENOG4105F1A Pyruvate formate-lyase H0E72_RS18955 ENOG4105EKQ RNA-directed DNA polymerase H0E72_RS18960 ENOG4105C2F Histidine kinase H0E72_RS18965 ENOG4106R3P AraC family transcriptional regulator H0E72_RS18975 ENOG4105KNY Microcompartments protein H0E72_RS19025 ENOG4105TS0 gtp-binding protein H0E72_RS19030 ENOG4108KZE transcriptional regulator H0E72_RS19045 ENOG4106H6R UPF0380 protein H0E72_RS19050 ENOG4106549 Antirestriction protein H0E72_RS19055 ENOG4108YGG dna repair protein H0E72_RS19065 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles H0E72_RS19095 ENOG4105C2X Arabinose 5-phosphate isomerase H0E72_RS19100 ENOG4105ECX polysaccharide export H0E72_RS19105 ENOG4107V1M polysaccharide export protein H0E72_RS19110 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) H0E72_RS19115 ENOG4105E12 capsule polysaccharide H0E72_RS19120 ENOG41084CK capsule polysaccharide H0E72_RS19125 ENOG41090SZ ABC-2 type transporter H0E72_RS19150 ENOG4105U1E general secretion pathway protein M H0E72_RS19170 ENOG4105X5Z General secretion pathway protein I H0E72_RS19180 ENOG4108VAU general secretion pathway protein G H0E72_RS19185 ENOG4105D7Q type ii secretion system H0E72_RS19190 ENOG4107QHF type ii secretion system protein e H0E72_RS19205 ENOG410765S (LipO)protein H0E72_RS19215 ENOG4105F88 accessory colonization factor AcfD H0E72_RS19220 ENOG4105DAA L-lactate H0E72_RS19225 ENOG4107QP3 malate synthase g H0E72_RS19230 ENOG4108ZJF Glcg protein H0E72_RS19235 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) H0E72_RS19240 ENOG4105EU8 FAD linked oxidase domain protein H0E72_RS19245 ENOG4105CQB FAD linked oxidase domain protein H0E72_RS19250 ENOG4108KWP DNA-binding transcriptional regulator GlcC H0E72_RS19260 ENOG4107RCI amp-dependent synthetase and ligase H0E72_RS19270 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) H0E72_RS19275 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H0E72_RS19285 ENOG4108M8S permease YjgP YjgQ family protein H0E72_RS19290 ENOG4108UUE Transcriptional regulator H0E72_RS19300 ENOG4108S55 polysaccharide biosynthesis protein H0E72_RS19305 ENOG4106FPV ATP-binding protein YghR H0E72_RS19310 ENOG4108NDC ATP-binding protein yghS H0E72_RS19315 ENOG4108GH0 ATP-binding protein yghT H0E72_RS19320 ENOG4105CJ3 phosphate transporter H0E72_RS19325 ENOG4106032 Glutathionylspermidine synthase H0E72_RS19330 ENOG4105CYM Glutathione S-transferase H0E72_RS19340 ENOG41082MF Hydrogenase assembly chaperone hypC hupF H0E72_RS19350 ENOG4108WGS hydrogenase 2-specific chaperone H0E72_RS19355 ENOG4108USZ hydrogenase H0E72_RS19360 ENOG4105DPX Hydrogenase, large subunit H0E72_RS19365 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit H0E72_RS19370 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0E72_RS19375 ENOG4105E3S small subunit H0E72_RS19380 ENOG410900S Protein of unknown function (DUF2623) H0E72_RS19390 ENOG4105CPC Aldo Keto reductase H0E72_RS19400 ENOG4105CYX Short-chain dehydrogenase reductase Sdr H0E72_RS19405 ENOG4108ZZF transport protein (ExbD) H0E72_RS19410 ENOG4105CWK Biopolymer transport protein, ExbB H0E72_RS19415 ENOG4105C28 cystathionine H0E72_RS19420 ENOG4108K81 inner membrane protein YghB H0E72_RS19425 ENOG4105CF7 AraC family transcriptional regulator H0E72_RS19430 ENOG4108I6A alcohol dehydrogenase H0E72_RS19435 ENOG4105CV8 reductase H0E72_RS19440 ENOG4105ZKC Conserved Protein H0E72_RS19450 ENOG4105CCT upf0313 protein H0E72_RS19455 ENOG4107YCY Transcriptional regulator H0E72_RS19460 ENOG4105DEI Mannitol dehydrogenase H0E72_RS19465 ENOG4105CPQ Dehydrogenase H0E72_RS19470 ENOG4105DG4 malate L-lactate dehydrogenase H0E72_RS19475 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H0E72_RS19485 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H0E72_RS19490 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) H0E72_RS19495 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase H0E72_RS19500 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0E72_RS19505 ENOG4108J59 Extracellular solute-binding protein, family 5 H0E72_RS19510 ENOG4105F4I Transcriptional regulator H0E72_RS19515 ENOG4105H4F exported protein H0E72_RS19520 ENOG4105XJC Two component transcriptional regulator (Winged helix family H0E72_RS19525 ENOG4105DHQ Histidine kinase H0E72_RS19530 ENOG4105NF4 modulator of drug activity H0E72_RS19535 ENOG4105VRH Antibiotic biosynthesis monooxygenase H0E72_RS19540 ENOG4106KNT transcriptional regulator H0E72_RS19550 ENOG4105EHG Permease protein H0E72_RS19555 ENOG4105DQ5 transport system permease protein H0E72_RS19560 ENOG4105E0A ABC, transporter H0E72_RS19570 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0E72_RS19575 ENOG4105IPS esterase H0E72_RS19580 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H0E72_RS19585 ENOG4108SX3 cytoplasmic protein H0E72_RS19590 ENOG41087AY ADP-Ribose pyrophosphatase H0E72_RS19595 ENOG4105DFG type I secretion outer membrane protein H0E72_RS19605 ENOG4106032 Glutathionylspermidine synthase H0E72_RS19610 ENOG4108MR7 Arylsulfotransferase H0E72_RS19615 ENOG4108N92 Thiol disulfide Interchange Protein H0E72_RS19625 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b H0E72_RS19645 ENOG4105W0Z cytoplasmic protein H0E72_RS19655 ENOG4105PV3 Inner membrane protein yqiJ H0E72_RS19660 ENOG4107S78 Band 7 protein H0E72_RS19685 ENOG4105I7R Adenylate cyclase H0E72_RS19690 ENOG4106MWK domain protein H0E72_RS19705 ENOG4107ZVW dihydroneopterin aldolase H0E72_RS19715 ENOG4105EJC lysr family transcriptional regulator H0E72_RS19720 ENOG4106DSS Tartrate dehydratase subunit alpha H0E72_RS19725 ENOG4107GFK fumarate H0E72_RS19730 ENOG4107QPK )-transporter H0E72_RS19745 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) H0E72_RS19750 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0E72_RS19770 ENOG4105Q26 Siderophore-interacting protein H0E72_RS19775 ENOG4105NTW Transcriptional regulator H0E72_RS19780 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor H0E72_RS19790 ENOG4108Y51 tRNA-binding protein H0E72_RS19795 ENOG4105CQ4 Transcriptional regulator H0E72_RS19800 ENOG4105CNT hydrolase family 2 H0E72_RS19805 ENOG4105FK9 beta-D-galactosidase beta subunit H0E72_RS19810 ENOG4105E5D amino acid H0E72_RS19815 ENOG4107W6W Conserved Protein H0E72_RS19820 ENOG4107WCA isomerase H0E72_RS19825 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase H0E72_RS19835 ENOG4108VKG metal-dependent hydrolase H0E72_RS19840 ENOG4108UB4 uncharacterized protein ygjQ H0E72_RS19845 ENOG4105EE0 oxidoreductase H0E72_RS19850 ENOG4105DU1 integral membrane protein, terc H0E72_RS19855 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) H0E72_RS19860 ENOG4105P66 Membrane H0E72_RS19865 ENOG4105CTX dehydratase H0E72_RS19875 ENOG4105DPW Major facilitator superfamily MFS_1 H0E72_RS19900 ENOG4107YCY Transcriptional regulator H0E72_RS19905 ENOG4106W5V Membrane H0E72_RS19910 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) H0E72_RS19915 ENOG4105WAY exported protein H0E72_RS19920 ENOG4105NE1 Conserved Protein H0E72_RS19925 ENOG41090KG Inner membrane protein YqjE H0E72_RS19930 ENOG4105YJD H0E72_RS19935 ENOG4108VBZ doxx family H0E72_RS19940 ENOG4105CHF Glutathione S-transferase H0E72_RS19945 ENOG4105KAF membrAne H0E72_RS19950 ENOG4105KAF membrAne H0E72_RS19955 ENOG4105CWB LysR family transcriptional Regulator H0E72_RS19960 ENOG4108CNN domain protein H0E72_RS19965 ENOG4106D80 Uncharacterized protein YhaL H0E72_RS19975 ENOG4105C44 Serine transporter H0E72_RS20000 ENOG4105F2I Transposase H0E72_RS20015 ENOG4105EJQ L-serine dehydratase H0E72_RS20020 ENOG4105KME endoribonuclease L-psp H0E72_RS20025 ENOG4105C6N Formate acetyltransferase H0E72_RS20030 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) H0E72_RS20035 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) H0E72_RS20040 ENOG4105C7B Threonine dehydratase H0E72_RS20045 ENOG410811B TRANSCRIPTIONal H0E72_RS20070 ENOG4105BZW Glycerate kinase H0E72_RS20075 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H0E72_RS20085 ENOG4105DJB Major Facilitator Superfamily H0E72_RS20090 ENOG4105CTX dehydratase H0E72_RS20095 ENOG4105ZEG Suppressor protein H0E72_RS20100 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression H0E72_RS20105 ENOG4105E98 transcriptional regulator DeoR family H0E72_RS20115 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB H0E72_RS20125 ENOG4105F3R pts system mannose fructose sorbose family iid H0E72_RS20130 ENOG4108YTN IIa component H0E72_RS20135 ENOG4105CE4 GlcNAc 6-P deacetylase H0E72_RS20140 ENOG4105E70 isomerase H0E72_RS20150 ENOG4108UZY PTS System H0E72_RS20155 ENOG4105ETZ PTS System H0E72_RS20160 ENOG4105F3R pts system mannose fructose sorbose family iid H0E72_RS20165 ENOG4106HBN Galactosamine-6-phosphate isomerase H0E72_RS20170 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) H0E72_RS20190 ENOG4105W4M Transport-associated protein H0E72_RS20195 ENOG4107S21 permease H0E72_RS20200 ENOG4105K4T epimerase H0E72_RS20205 ENOG4107R7Y intracellular protease Pfpi family H0E72_RS20220 ENOG4108YYD acetyltransferase H0E72_RS20240 ENOG4105DEN Luciferase family H0E72_RS20245 ENOG4105CIC tryptophan-specific transport protein H0E72_RS20250 ENOG4105C1J atp-dependent rna helicase H0E72_RS20290 ENOG4105CHV Transcription elongation factor NusA H0E72_RS20310 ENOG4105DIJ Phosphoethanolamine transferase H0E72_RS20320 ENOG4105NTZ Preprotein translocase subunit SecG H0E72_RS20330 ENOG4105EEI dihydropteroate synthase H0E72_RS20335 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H0E72_RS20345 ENOG4105HBR Rna-binding protein H0E72_RS20350 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) H0E72_RS20355 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase H0E72_RS20365 ENOG4105QYV Membrane H0E72_RS20380 ENOG4105EAH synthase H0E72_RS20385 ENOG4105HVQ Regulatory factor of maltose metabolism H0E72_RS20395 ENOG4105VFK BolA family H0E72_RS20400 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane H0E72_RS20405 ENOG4105E3I toluene tolerance H0E72_RS20410 ENOG4107PE3 Mammalian cell entry related domain protein H0E72_RS20415 ENOG4105CY3 ABC transporter, permease H0E72_RS20420 ENOG4105DHJ ABC, transporter H0E72_RS20425 ENOG4105FEU K -dependent Na -Ca exchanger H0E72_RS20430 ENOG4105C2X Arabinose 5-phosphate isomerase H0E72_RS20440 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) H0E72_RS20445 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA H0E72_RS20450 ENOG4108IUZ ABC transporter H0E72_RS20455 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0E72_RS20460 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA H0E72_RS20465 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN H0E72_RS20475 ENOG41080Z8 PHOSPHOCARRIER protein H0E72_RS20480 ENOG4108NIH transferase activity, transferring phosphorus-containing groups H0E72_RS20490 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain H0E72_RS20495 ENOG4105BZU Histidine kinase H0E72_RS20500 ENOG4105N5T Radical SAM Protein H0E72_RS20505 ENOG4105CBC glutamate synthase H0E72_RS20510 ENOG4105BZ8 glutamate synthase H0E72_RS20525 ENOG4105KKX ATPase associated with various cellular activities aaa_5 H0E72_RS20535 ENOG4105DEG Vwa containing coxe family protein H0E72_RS20550 ENOG4108R66 Conserved Protein H0E72_RS20580 ENOG4105CEE C4-dicarboxylate transporter H0E72_RS20585 ENOG4105KB2 stringent starvation protein b H0E72_RS20590 ENOG4107MKT Stringent starvation protein a H0E72_RS20605 ENOG4105D6Z AFG1 family ATPase H0E72_RS20610 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III H0E72_RS20615 ENOG4105C0H protease H0E72_RS20620 ENOG4105C0H protease H0E72_RS20635 ENOG4105RID UPF0379 protein yhcN H0E72_RS20640 ENOG4105UNR (Barnase) inhibitor H0E72_RS20655 ENOG4105ZQC membrane protein AaeX H0E72_RS20660 ENOG4105CR8 Transcriptional regulator H0E72_RS20665 ENOG4105D1U peptidase U62 modulator of DNA gyrase H0E72_RS20670 ENOG4105QD6 exported protein H0E72_RS20675 ENOG4105C03 ribonuclease H0E72_RS20685 ENOG4105VQ7 Rod shape-determining protein MreD H0E72_RS20690 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) H0E72_RS20700 ENOG41062P1 Diguanylate cyclase phosphodiesterase H0E72_RS20705 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family H0E72_RS20715 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein H0E72_RS20720 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase H0E72_RS20725 ENOG4105RG0 Membrane H0E72_RS20730 ENOG4108IA2 Sodium pantothenate symporter H0E72_RS20740 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) H0E72_RS20750 ENOG4105CEC DNA methylase N-4 N-6 H0E72_RS20755 ENOG41061ME transport protein H0E72_RS20760 ENOG4108XG4 DNA-binding transcriptional regulator H0E72_RS20765 ENOG4105C1P efflux transporter, rnd family, mfp subunit H0E72_RS20775 ENOG4105XCM membrane LIPOPROTEIN H0E72_RS20785 ENOG4105EZ7 amino acid ABC transporter H0E72_RS20790 ENOG4105DRP amino acid AbC transporter H0E72_RS20795 ENOG4105CDA abc transporter atp-binding protein H0E72_RS20835 ENOG4108Z0R Transferase H0E72_RS20840 ENOG4105SG3 Protein of unknown function (DUF1488) H0E72_RS20855 ENOG4108WI1 Dna topoisomerase H0E72_RS20865 ENOG4105C79 DNA protecting protein DprA H0E72_RS20885 ENOG4105C1A potassium transporter peripheral membrane H0E72_RS20895 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system H0E72_RS20900 ENOG4105W1Y Transcriptional regulator H0E72_RS20905 ENOG4105VTS DnaJ-like, subfamily C H0E72_RS20935 ENOG41067V7 50S ribosomal protein L36 H0E72_RS20940 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) H0E72_RS20985 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) H0E72_RS21030 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) H0E72_RS21055 ENOG4108UQY Iron-storage protein H0E72_RS21060 ENOG4105W53 bacterioferritin-associated ferredoxin H0E72_RS21090 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) H0E72_RS21100 ENOG4105WWK YheO domain protein H0E72_RS21105 ENOG4108V1T peptidylprolyl cis-trans isomerase H0E72_RS21115 ENOG4108YZY peptidylprolyl cis-trans isomerase H0E72_RS21120 ENOG4105VKU nucleicacid-binding protein H0E72_RS21135 ENOG4105C5H ABC transporter H0E72_RS21140 ENOG4105DNZ Alpha Beta Hydrolase H0E72_RS21150 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) H0E72_RS21155 ENOG4108UKZ OsmC family H0E72_RS21165 ENOG410613R integral membrane protein, YccS YhfK family H0E72_RS21170 ENOG4105C8Y Acetylornithine aminotransferase H0E72_RS21175 ENOG4105DDQ anthranilate synthase H0E72_RS21180 ENOG4105MZU cell filamentation protein H0E72_RS21190 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) H0E72_RS21200 ENOG4107QZF nitrite reductase NADPH large subunit H0E72_RS21205 ENOG4105WZK nitrite reductase NADPH small subunit H0E72_RS21210 ENOG4107V9H nitrite transporter H0E72_RS21220 ENOG4105VYH H0E72_RS21225 ENOG4106PKC pyridoxal phosphate binding H0E72_RS21230 ENOG4106M0N transport system permease protein H0E72_RS21235 ENOG4105MUZ Protein of unknown function DUF2620 H0E72_RS21240 ENOG41080QX K07048 phosphotriesterase-related protein H0E72_RS21245 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) H0E72_RS21250 ENOG4108626 Racemase H0E72_RS21255 ENOG4105RMW regulation of transcription, DNA-dependent H0E72_RS21260 ENOG4108M21 H0E72_RS21265 ENOG4105C31 Tryptophanyl-tRNA synthetase H0E72_RS21270 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) H0E72_RS21275 ENOG4105DJV ribulose-phosphate 3-epimerase H0E72_RS21280 ENOG4105DFE Dna adenine methylase H0E72_RS21285 ENOG4105EGB membrane protein DamX H0E72_RS21300 ENOG4105E4G Type IV pilus H0E72_RS21305 ENOG4105ITY Required for the use of extracellular DNA as a nutrient H0E72_RS21310 ENOG4105XPX DNA utilization protein HofO H0E72_RS21315 ENOG41065NF Fimbrial assembly family protein H0E72_RS21320 ENOG4108U1Q Pilus assembly protein H0E72_RS21325 ENOG4108JQC penicillin-binding protein 1A H0E72_RS21330 ENOG4107RK2 ADP-ribose diphosphatase NudE H0E72_RS21335 ENOG4105DQY intracellular growth attenuator H0E72_RS21340 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 H0E72_RS21345 ENOG4105VEJ Heat shock protein H0E72_RS21355 ENOG4108MAJ Membrane H0E72_RS21375 ENOG4105E0F Histidine kinase H0E72_RS21385 ENOG4108RRZ Transcription elongation factor GreB H0E72_RS21390 ENOG4105BZM domain protein H0E72_RS21395 ENOG4105XFK Ferrous iron transport protein A H0E72_RS21400 ENOG4105CE1 Ferrous iron transport protein b H0E72_RS21410 ENOG4105DNE Transposase H0E72_RS21420 ENOG4105MJ2 Competence protein H0E72_RS21430 ENOG4105C6Z Gluconate H0E72_RS21435 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) H0E72_RS21440 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) H0E72_RS21455 ENOG4105E0Y RtcB Protein H0E72_RS21460 ENOG4105CYB regulatoR H0E72_RS21465 ENOG4105E98 transcriptional regulator DeoR family H0E72_RS21480 ENOG4105C6V Glycerol-3-phosphate dehydrogenase H0E72_RS21500 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) H0E72_RS21520 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) H0E72_RS21525 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) H0E72_RS21530 ENOG41076UM multiple antibiotic resistance (MarC)-related protein H0E72_RS21540 ENOG4105C9U ATP-dependent DNA helicase RecQ H0E72_RS21545 ENOG4105C6Z Gluconate H0E72_RS21550 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family H0E72_RS21555 ENOG4105DIQ Transcriptional regulator H0E72_RS21560 ENOG4105C2I pirin domain protein H0E72_RS21565 ENOG4105D9R oxidoreductase H0E72_RS21570 ENOG4105WCN acetyltransferase H0E72_RS21575 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) H0E72_RS21580 ENOG4105WC8 Conserved Protein H0E72_RS21585 ENOG4107T6V glycerophosphoryl diester phosphodiesterase H0E72_RS21605 ENOG4105BZ7 extracellular solute-binding protein family 1 H0E72_RS21615 ENOG4108IV0 ABC, transporter H0E72_RS21620 ENOG4105C0Z ABC transporter H0E72_RS21625 ENOG4105CF8 branched-chain amino acid ABC transporter, permease H0E72_RS21630 ENOG4105C32 Amino acid ABC transporter (Permease) H0E72_RS21635 ENOG4105CP9 extracellular ligand-binding receptor H0E72_RS21640 ENOG4105U59 -acetyltransferase H0E72_RS21645 ENOG4105CP9 extracellular ligand-binding receptor H0E72_RS21650 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0E72_RS21655 ENOG4105CRP Part of the ABC transporter FtsEX involved in H0E72_RS21660 ENOG4105CAK Cell division ATP-binding protein ftsE H0E72_RS21665 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) H0E72_RS21670 ENOG4106H78 methyltransferase H0E72_RS21675 ENOG4105MG3 Membrane H0E72_RS21685 ENOG4107FS9 Membrane H0E72_RS21705 ENOG4105EX9 Membrane H0E72_RS21710 ENOG4108W1V Lipoprotein H0E72_RS21715 ENOG4105F9N Major Facilitator Superfamily H0E72_RS21720 ENOG4105DSF transport protein H0E72_RS21725 ENOG4107YAK holo-(acyl carrier protein) synthase 2 H0E72_RS21730 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein H0E72_RS21735 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H0E72_RS21740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H0E72_RS21745 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) H0E72_RS21770 ENOG41090UW PTS System H0E72_RS21775 ENOG4105DT3 PTS system, galactitol-specific IIc component H0E72_RS21780 ENOG4105CMG Carbohydrate kinase H0E72_RS21790 ENOG4105D2N Aldolase H0E72_RS21805 ENOG4105CMI transporter H0E72_RS21810 ENOG4105CJ1 ABC, transporter H0E72_RS21815 ENOG4105D0S secretion protein (HlyD H0E72_RS21830 ENOG4107UNS conserved inner membrane protein H0E72_RS21835 ENOG4105CBX hi0933 family H0E72_RS21840 ENOG4105CJ3 phosphate transporter H0E72_RS21855 ENOG4105DUX Transporter H0E72_RS21865 ENOG4105DGW oligopeptidase A H0E72_RS21870 ENOG4105D6S protein involved in catabolism of external DNA H0E72_RS21875 ENOG4105DC8 reductase H0E72_RS21885 ENOG4105KBH arsR family transcriptional regulator H0E72_RS21890 ENOG4107R5R arsenical pump membrane protein H0E72_RS21895 ENOG4105K89 arsenate reductase H0E72_RS21915 ENOG4105Y4Z Outer Membrane Lipoprotein H0E72_RS21925 ENOG4106QJH hemin transport protein H0E72_RS21930 ENOG4107ENK receptor H0E72_RS21940 ENOG4105D4P Coproporphyrinogen iii oxidase H0E72_RS21945 ENOG41090JE Utilization Protein H0E72_RS21955 ENOG4105EHG Permease protein H0E72_RS21960 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) H0E72_RS21965 ENOG4105KT7 mgtC SapB transporter H0E72_RS21970 ENOG4105XXV Acid-resistance protein H0E72_RS21975 ENOG41060V2 Acid-resistance protein H0E72_RS21980 ENOG4108YK4 Acid-resistance membrane protein H0E72_RS21985 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci H0E72_RS21995 ENOG4105C1P efflux transporter, rnd family, mfp subunit H0E72_RS22000 ENOG4105BZS acriflavin resistance protein H0E72_RS22015 ENOG4105CVK Glutamate decarboxylase H0E72_RS22020 ENOG4105CA0 peroxidase H0E72_RS22030 ENOG4106S2D Transcriptional regulator H0E72_RS22035 ENOG4105CBN LysR family transcriptional regulator H0E72_RS22040 ENOG4107H3J ribonuclease H0E72_RS22045 ENOG4105CSH Transporter H0E72_RS22050 ENOG41066T0 asmA family H0E72_RS22055 ENOG4105CMB EAL domain-containing protein H0E72_RS22060 ENOG4107SS6 2-dehydro-3-deoxygluconokinase H0E72_RS22080 ENOG4105CS0 peptidase H0E72_RS22090 ENOG4105BZU Histidine kinase H0E72_RS22095 ENOG4105EJG cellulose synthase H0E72_RS22100 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) H0E72_RS22105 ENOG4107EEX Cellulose synthase regulator protein H0E72_RS22110 ENOG4107QZ7 Cellulose synthase catalytic subunit H0E72_RS22120 ENOG410661M cytoplasmic protein H0E72_RS22125 ENOG4105U74 cellulose biosynthesis protein BcsE H0E72_RS22130 ENOG4105WQA Cellulose biosynthesis protein BcsF H0E72_RS22135 ENOG4105D1V cellulose synthase operon protein YhjU H0E72_RS22165 ENOG4105C44 Serine transporter H0E72_RS22170 ENOG4108JQ7 (ABC) transporter H0E72_RS22175 ENOG4105C3U ABC transporter H0E72_RS22180 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component H0E72_RS22185 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component H0E72_RS22190 ENOG4105DEF Extracellular solute-binding protein, family 5 H0E72_RS22200 ENOG4105DIJ Phosphoethanolamine transferase H0E72_RS22205 ENOG4105FCD Major Facilitator H0E72_RS22210 ENOG4105EAX Putative lipase H0E72_RS22215 ENOG4108R3E Dna-3-methyladenine glycosylase i H0E72_RS22220 ENOG4105HNP -acetyltransferase H0E72_RS22225 ENOG4107QY8 reductase H0E72_RS22230 ENOG4108ZG0 Ompa motb domain protein H0E72_RS22240 ENOG4106JH6 (LipO)protein H0E72_RS22245 ENOG4105MVF Transcriptional regulator H0E72_RS22255 ENOG41060TC Hok gef cell toxic protein H0E72_RS22280 ENOG4105MEV Acyl-transferase H0E72_RS22285 ENOG4108Z12 YiaAB two helix domain-containing protein H0E72_RS22290 ENOG410688U Inner membrane protein yiaB H0E72_RS22295 ENOG4105CMG Carbohydrate kinase H0E72_RS22305 ENOG4105DFW ABC transporter H0E72_RS22315 ENOG4108HWW ABC transporter H0E72_RS22320 ENOG4105T16 Transcriptional regulator (AraC family) H0E72_RS22325 ENOG4108UR8 BAX protein H0E72_RS22330 ENOG4107T9C Alpha amylase catalytic region H0E72_RS22335 ENOG4105JKW Valine--pyruvate aminotransferase H0E72_RS22340 ENOG4108XIB electron transport protein ysaA H0E72_RS22345 ENOG4105J4Q Transcriptional regulator H0E72_RS22355 ENOG4108R66 Conserved Protein H0E72_RS22360 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter H0E72_RS22365 ENOG4105CG6 trap dicarboxylate transporter dctm subunit H0E72_RS22370 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit H0E72_RS22375 ENOG4105CMG Carbohydrate kinase H0E72_RS22380 ENOG4105H6Q decarboxylase H0E72_RS22385 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase H0E72_RS22390 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase H0E72_RS22400 ENOG4105CT4 transporter H0E72_RS22410 ENOG4105GNX MltA-interacting MipA family protein H0E72_RS22415 ENOG4108Q2M Transcriptional regulator H0E72_RS22420 ENOG4105EFX secretion protein, HlyD family H0E72_RS22425 ENOG4105KK7 inner membrane protein YiaW H0E72_RS22435 ENOG4105C26 Dehydrogenase H0E72_RS22445 ENOG4105C0A alcohol dehydrogenase H0E72_RS22450 ENOG4105EM7 Selenocysteine-specific translation elongation factor H0E72_RS22460 ENOG4108U78 Glutathione S-transferase H0E72_RS22465 ENOG4108BMY protease H0E72_RS22510 ENOG4105EFX secretion protein, HlyD family H0E72_RS22515 ENOG4105FP6 Protein of unknown function (DUF3302) H0E72_RS22520 ENOG4105CTS PTS system mannitol-specific H0E72_RS22530 ENOG4105E61 Mannitol repressor protein H0E72_RS22535 ENOG41060ND LF82 chromosome, complete sequence H0E72_RS22540 ENOG4108YYI Protein of unknown function (DUF2810) H0E72_RS22545 ENOG4108WY4 inner membrane lipoprotein H0E72_RS22555 ENOG4105DAA L-lactate H0E72_RS22560 ENOG41073TP transcriptional regulator H0E72_RS22570 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) H0E72_RS22575 ENOG4105D7W serine acetyltransferase H0E72_RS22590 ENOG4105VW4 glutaredoxin 3 H0E72_RS22595 ENOG4107YZP Rhodanese domain protein H0E72_RS22605 ENOG41063SB peptidase H0E72_RS22610 ENOG4105PXI polysaccharide deacetylase H0E72_RS22615 ENOG4105K64 Glycosyl transferase, family 2 H0E72_RS22625 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) H0E72_RS22635 ENOG4105XA0 heptosyltransferase ii H0E72_RS22640 ENOG4105D16 lipopolysaccharide heptosyltransferase i H0E72_RS22645 ENOG41068PG O-Antigen polymerase H0E72_RS22650 ENOG4105K64 Glycosyl transferase, family 2 H0E72_RS22655 ENOG4105X1N Glycosyl transferase family 8 H0E72_RS22665 ENOG4105X1N Glycosyl transferase family 8 H0E72_RS22670 ENOG4106AH0 Glycosyl Transferase H0E72_RS22675 ENOG4107543 (lipo)polysaccharide H0E72_RS22680 ENOG4107RJ7 Glycosyl transferase (Group 1 H0E72_RS22685 ENOG4105DKP glycosyl transferase, family 9 H0E72_RS22690 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase H0E72_RS22710 ENOG4105KDC 50s ribosomal protein l28 H0E72_RS22720 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase H0E72_RS22725 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) H0E72_RS22745 ENOG4105DSJ YicC domain protein H0E72_RS22750 ENOG4105F5P DNA-damage-inducible protein d H0E72_RS22755 ENOG4105EN6 Membrane H0E72_RS22765 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) H0E72_RS22775 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) H0E72_RS22780 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase H0E72_RS22785 ENOG4105CB5 ATP-dependent DNA helicase recG H0E72_RS22790 ENOG4105D6U Sodium Glutamate Symporter H0E72_RS22795 ENOG4105C2W permease H0E72_RS22800 ENOG4105JV1 AsmA family H0E72_RS22810 ENOG4105DKQ ROK family H0E72_RS22820 ENOG4105D2N Aldolase H0E72_RS22825 ENOG4105DM4 PTS System H0E72_RS22830 ENOG4108YRF PTS System H0E72_RS22835 ENOG4105DM4 PTS System H0E72_RS22840 ENOG4105ETD TRANSCRIPTIONal H0E72_RS22845 ENOG4105CJQ hydrolase, family 31 H0E72_RS22850 ENOG4105CT4 transporter H0E72_RS22860 ENOG4105DFP Integrase H0E72_RS22870 ENOG4108I6E Sulfatase H0E72_RS22875 ENOG4105T40 surface antigen msp4 family protein H0E72_RS22895 ENOG4105CVR type I restriction-modification system H0E72_RS22960 ENOG4108YXQ IS66 Orf2 family protein H0E72_RS23030 ENOG4108SAU DNA-binding protein H-ns H0E72_RS23065 ENOG4105TS0 gtp-binding protein H0E72_RS23070 ENOG4108KZE transcriptional regulator H0E72_RS23085 ENOG4106H6R UPF0380 protein H0E72_RS23090 ENOG4105MFG Antirestriction protein H0E72_RS23095 ENOG4108YGG dna repair protein H0E72_RS23105 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles H0E72_RS23135 ENOG4105S8Q sugar efflux transporter H0E72_RS23140 ENOG4108UZ3 Transporter H0E72_RS23145 ENOG4105D01 (LipO)protein H0E72_RS23150 ENOG4105T8A Uncharacterized protein YicS H0E72_RS23175 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC H0E72_RS23180 ENOG4108YAB Invasion protein H0E72_RS23185 ENOG4105TNG K13735 adhesin invasin H0E72_RS23205 ENOG4108SAJ Protein of unknown function (DUF1198) H0E72_RS23210 ENOG4105C7N Xanthine uracil vitamin C permease H0E72_RS23220 ENOG4105CXY transporter H0E72_RS23225 ENOG4105CXY transporter H0E72_RS23230 ENOG4105BZU Histidine kinase H0E72_RS23235 ENOG4108KX4 response regulator H0E72_RS23250 ENOG4105M71 acetolactate synthase 1 regulatory subunit H0E72_RS23255 ENOG4105C7K acetolactate synthase H0E72_RS23270 ENOG4105E5M Multidrug resistance protein D H0E72_RS23275 ENOG4105J13 transcriptional regulator H0E72_RS23280 ENOG4105JP4 Inner membrane protein yidG H0E72_RS23285 ENOG4105VG5 Membrane H0E72_RS23290 ENOG4105CBG Sulfatase H0E72_RS23295 ENOG4107RUZ Sss sodium solute transporter superfamily H0E72_RS23300 ENOG4108AHD Transcriptional regulator H0E72_RS23305 ENOG4105F8D glycoside hydrolase family 4 H0E72_RS23310 ENOG4105CI1 PTS System H0E72_RS23315 ENOG4105FDP GntR family transcriptional regulator H0E72_RS23335 ENOG4105R2A (LipO)protein H0E72_RS23340 ENOG4105D99 atp gtp-binding protein H0E72_RS23350 ENOG4105DJB Major Facilitator Superfamily H0E72_RS23360 ENOG4108RTU Aldolase H0E72_RS23365 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 H0E72_RS23370 ENOG4105EMF GntR family transcriptional regulator H0E72_RS23375 ENOG410657R replicase EC 2.7 H0E72_RS23380 ENOG410667J hydrolase H0E72_RS23385 ENOG4105VP5 Bacterial protein of unknown function (DUF937) H0E72_RS23390 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) H0E72_RS23400 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) H0E72_RS23415 ENOG4105VG0 50S ribosomal protein l34 H0E72_RS23460 ENOG4105G2Y Transcriptional regulator H0E72_RS23465 ENOG4105E8Q phosphopantetheinyl transferase H0E72_RS23470 ENOG4108YYH Nadph-dependent fmn reductase H0E72_RS23475 ENOG4105C7N Xanthine uracil vitamin C permease H0E72_RS23480 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 H0E72_RS23505 ENOG4108UTW Plays a role in the regulation of phosphate uptake H0E72_RS23510 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) H0E72_RS23515 ENOG4105E2Z phosphate ABC transporter (Permease H0E72_RS23520 ENOG4105C8U phosphate abc transporter H0E72_RS23525 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) H0E72_RS23535 ENOG4105CW0 outer membrane usher protein H0E72_RS23545 ENOG4108RQP Major type 1 subunit fimbrin H0E72_RS23550 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) H0E72_RS23600 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation H0E72_RS23615 ENOG4105QTB Flavodoxin H0E72_RS23620 ENOG4108VVK transcriptional Regulator, AsnC H0E72_RS23640 ENOG4105VNT transposase (IS4 family) protein H0E72_RS23655 ENOG4105C2J ABC transporter H0E72_RS23660 ENOG4105CNN ABC, transporter H0E72_RS23665 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator H0E72_RS23670 ENOG4108RVA ribokinase H0E72_RS23675 ENOG4105ETE Transcriptional regulator (LacI family H0E72_RS23680 ENOG4105C0R drug resistance transporter emrb qaca subfamily H0E72_RS23685 ENOG4107EJG GntR family transcriptional regulator H0E72_RS23725 ENOG4108WFC UPF0438 protein yifE H0E72_RS23730 ENOG4105C0P Mg chelatase subunit ChlI H0E72_RS23750 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit H0E72_RS23755 ENOG4105CM2 brancheD-chain amino acid aminotransferase H0E72_RS23765 ENOG4105C7B Threonine dehydratase H0E72_RS23770 ENOG4105EMY transcriptional regulator H0E72_RS23780 ENOG4105KQ5 peptidylprolyl cis-trans isomerase H0E72_RS23790 ENOG4105C4R Atp-dependent dna helicase H0E72_RS23815 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) H0E72_RS23820 ENOG4105ESV Glycosyl transferase, family 4 H0E72_RS23825 ENOG4105SFE lipopolysaccharide biosynthesis protein H0E72_RS23830 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase H0E72_RS23835 ENOG4107QQG Dehydrogenase H0E72_RS23840 ENOG4105C1B dTDP-glucose 4-6-dehydratase H0E72_RS23845 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) H0E72_RS23850 ENOG4108WJ1 acetyltransferase H0E72_RS23855 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase H0E72_RS23860 ENOG4105EGZ biosynthesis protein H0E72_RS23880 ENOG4105C85 amino acid H0E72_RS23905 ENOG4105C4X radical SAM domain protein H0E72_RS23910 ENOG4105ENH Sulfatase H0E72_RS23915 ENOG410601J HemY protein H0E72_RS23920 ENOG4105ECF c-methyltransferase H0E72_RS23925 ENOG41076E6 Uroporphyrinogen-III Synthase H0E72_RS23930 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) H0E72_RS23935 ENOG4107T0K Adenylate cyclase H0E72_RS23950 ENOG4105S7Z (LipO)protein H0E72_RS23960 ENOG4105CT0 Protein of unknown function, DUF484 H0E72_RS23970 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant H0E72_RS23975 ENOG4105C4R Atp-dependent dna helicase H0E72_RS23980 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase H0E72_RS23985 ENOG4108T58 Mg2 transport protein CorA H0E72_RS23990 ENOG4107QUT magnesium and cobalt transport protein CorA H0E72_RS24005 ENOG4105FR1 rard protein H0E72_RS24010 ENOG4108VUY thioesterase Superfamily protein H0E72_RS24015 ENOG4105HDD phospholipase H0E72_RS24020 ENOG4105C9U ATP-dependent DNA helicase RecQ H0E72_RS24025 ENOG4105CCF Lysine exporter protein (Lyse ygga) H0E72_RS24030 ENOG410829K Lysine exporter protein (Lyse ygga) H0E72_RS24035 ENOG4108EUD Lysophospholipase H0E72_RS24040 ENOG4105DQF Hydrolase H0E72_RS24045 ENOG4105EMK carboxylate amino acid amine transporter H0E72_RS24050 ENOG4105DZ2 Transcriptional regulator H0E72_RS24060 ENOG4105F52 Transcriptional regulator H0E72_RS24065 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin H0E72_RS24075 ENOG4105C5B carbamate kinase H0E72_RS24080 ENOG4107REC cytoplasmic protein H0E72_RS24095 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) H0E72_RS24100 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) H0E72_RS24105 ENOG4108I5U Uridine phosphorylase H0E72_RS24120 ENOG4105JN3 extra-cytoplasmic solute receptor family protein H0E72_RS24125 ENOG4108RTU Aldolase H0E72_RS24130 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 H0E72_RS24135 ENOG4107HP6 Transcriptional regulator H0E72_RS24140 ENOG4105CGY Dna recombination protein H0E72_RS24150 ENOG4105JC1 sterol-binding domain protein H0E72_RS24160 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) H0E72_RS24165 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) H0E72_RS24170 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) H0E72_RS24180 ENOG4105MDZ Transcriptional activator rfaH H0E72_RS24185 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) H0E72_RS24190 ENOG4108EX3 reductase H0E72_RS24210 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein H0E72_RS24215 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) H0E72_RS24220 ENOG4108RR8 protoporphyrinogen oxidase H0E72_RS24250 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b H0E72_RS24255 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) H0E72_RS24260 ENOG4105PC1 Conserved Protein H0E72_RS24265 ENOG4105E27 serine threonine protein kinase H0E72_RS24270 ENOG4108Z33 Thiol disulfide Interchange Protein H0E72_RS24280 ENOG4106HNH Acyl-transferase H0E72_RS24285 ENOG4105C2M dna polymerase I H0E72_RS24300 ENOG4105D4P Coproporphyrinogen iii oxidase H0E72_RS24305 ENOG4106FIY H0E72_RS24310 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family H0E72_RS24315 ENOG4105CUX Signal transduction histidine kinase H0E72_RS24320 ENOG4105C5F glutamine synthetase H0E72_RS24325 ENOG4105CI3 gtp-binding protein typa H0E72_RS24330 ENOG4108K85 Transcriptional regulator H0E72_RS24335 ENOG4108KHF Resistance protein H0E72_RS24340 ENOG4105R9B Major Facilitator H0E72_RS24345 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is H0E72_RS24350 ENOG4105CT4 transporter H0E72_RS24355 ENOG4105CT4 transporter H0E72_RS24360 ENOG4105CJQ hydrolase, family 31 H0E72_RS24365 ENOG4107WI4 Aldose-1-epimerase H0E72_RS24370 ENOG4107QKS N-acylglucosamine 2-epimerase H0E72_RS24375 ENOG4105D2M Aldolase H0E72_RS24380 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase H0E72_RS24385 ENOG4108MGF sugar kinase H0E72_RS24390 ENOG4105E98 transcriptional regulator DeoR family H0E72_RS24395 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 H0E72_RS24410 ENOG4105SUU thioesterase domain H0E72_RS24425 ENOG41068KX affects formate dehydrogenase-N H0E72_RS24435 ENOG4108MG3 formate dehydrogenase H0E72_RS24440 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein H0E72_RS24455 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) H0E72_RS24465 ENOG4108V87 frv operon regulatory protein H0E72_RS24470 ENOG4106C3V frv operon regulatory protein H0E72_RS24475 ENOG4105CN9 Peptidase m42 family protein H0E72_RS24480 ENOG4105DM4 PTS System H0E72_RS24485 ENOG41064BA PTS system, fructose-specific, IIA component H0E72_RS24520 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) H0E72_RS24530 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) H0E72_RS24540 ENOG4108RPX mosc domain containing protein H0E72_RS24545 ENOG4105E0F Histidine kinase H0E72_RS24550 ENOG4105E3W Two component transcriptional regulator (Winged helix family H0E72_RS24555 ENOG4105FMW periplasmic H0E72_RS24560 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) H0E72_RS24600 ENOG4106CQM replication H0E72_RS24725 ENOG41073YN Protein of unknown function (DUF1380) H0E72_RS24730 ENOG4106JQ7 H0E72_RS24860 ENOG4108YXQ IS66 Orf2 family protein H0E72_RS24865 ENOG4105E5H Transposase H0E72_RS24895 ENOG4105KK6 nuclease H0E72_RS24925 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) H0E72_RS25035 ENOG4105CZX twitching motility protein H0E72_RS25085 ENOG4105K5T PilT protein H0E72_RS25100 ENOG4107QHF type ii secretion system protein e H0E72_RS25205 ENOG4107258 Transcriptional regulator H0E72_RS25215 ENOG4105KME endoribonuclease L-psp H0E72_RS25235 ENOG4105DRS transport system, permease H0E72_RS25240 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) H0E72_RS25245 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) H0E72_RS25270 ENOG4108BUD transposase H0E72_RS25290 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H0E72_RS25295 ENOG4107R39 (ABC) transporter H0E72_RS25300 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) H0E72_RS25315 ENOG4107SJW iron permease, FTR1 H0E72_RS25320 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) H0E72_RS25325 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen H0E72_RS25355 ENOG4108ZHR arsR family transcriptional regulator H0E72_RS25395 ENOG4108BUD transposase H0E72_RS25415 ENOG4108BUD transposase H0E72_RS25425 ENOG4105I1F Resistance protein H0E72_RS25435 ENOG4108BUD transposase H0E72_RS25590 ENOG4105ESI atpase involved in dna repair H0E72_RS25655 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) H0E72_RS25700 ENOG4107QJE Chromosome Partitioning Protein H0E72_RS25720 ENOG4108BUD transposase H0E72_RS25730 ENOG4105EPC oxidoreductase H0E72_RS25735 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase H0E72_RS25750 ENOG4105F2I Transposase H0E72_RS25755 ENOG4105F9F transposase H0E72_RS25810 ENOG4108X73 DNA- binding protein H0E72_RS25815 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) H0E72_RS25820 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) H0E72_RS25825 ENOG4105KK6 nuclease H0E72_RS25850 ENOG4108EHY type IV secretion system