locus-tag class description FK536_RS00025 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FK536_RS00035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FK536_RS00040 ENOG4105VP5 Bacterial protein of unknown function (DUF937) FK536_RS00045 ENOG410667J hydrolase FK536_RS00050 ENOG410657R replicase EC 2.7 FK536_RS00055 ENOG4105EMF GntR family transcriptional regulator FK536_RS00060 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FK536_RS00065 ENOG4108RTU Aldolase FK536_RS00075 ENOG4105DJB Major Facilitator Superfamily FK536_RS00085 ENOG4105D99 atp gtp-binding protein FK536_RS00090 ENOG4105R2A (LipO)protein FK536_RS00110 ENOG4105FDP GntR family transcriptional regulator FK536_RS00115 ENOG4105CI1 PTS System FK536_RS00125 ENOG4108AHD Transcriptional regulator FK536_RS00130 ENOG4107RUZ Sss sodium solute transporter superfamily FK536_RS00135 ENOG4105CBG Sulfatase FK536_RS00140 ENOG4106DRA Inner membrane protein YidI FK536_RS00145 ENOG4105VG5 Membrane FK536_RS00150 ENOG4105JP4 Inner membrane protein yidG FK536_RS00155 ENOG4105J13 transcriptional regulator FK536_RS00160 ENOG4105E5M Multidrug resistance protein D FK536_RS00175 ENOG4105C7K acetolactate synthase FK536_RS00180 ENOG4105M71 acetolactate synthase 1 regulatory subunit FK536_RS00185 ENOG4108KX4 response regulator FK536_RS00190 ENOG4105BZU Histidine kinase FK536_RS00195 ENOG4105CXY transporter FK536_RS00200 ENOG4105CXY transporter FK536_RS00205 ENOG4105CPN adenine deaminase FK536_RS00210 ENOG4105C7N Xanthine uracil vitamin C permease FK536_RS00215 ENOG4108SAJ Protein of unknown function (DUF1198) FK536_RS00225 ENOG4105T8A Uncharacterized protein YicS FK536_RS00230 ENOG4105D01 (LipO)protein FK536_RS00235 ENOG4108UZ3 Transporter FK536_RS00240 ENOG4105S8Q sugar efflux transporter FK536_RS00255 ENOG4105CT4 transporter FK536_RS00260 ENOG4105CJQ hydrolase, family 31 FK536_RS00265 ENOG4105JV1 AsmA family FK536_RS00270 ENOG4105C2W permease FK536_RS00275 ENOG4105D6U Sodium Glutamate Symporter FK536_RS00280 ENOG4105CB5 ATP-dependent DNA helicase recG FK536_RS00285 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FK536_RS00290 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FK536_RS00300 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FK536_RS00305 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) FK536_RS00310 ENOG4105EN6 Membrane FK536_RS00315 ENOG4105F5P DNA-damage-inducible protein d FK536_RS00400 ENOG4105DSJ YicC domain protein FK536_RS00420 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FK536_RS00425 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FK536_RS00430 ENOG4105W5Q DNA repair protein (RadC FK536_RS00435 ENOG4105KDC 50s ribosomal protein l28 FK536_RS00455 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FK536_RS00460 ENOG4105DKP glycosyl transferase, family 9 FK536_RS00465 ENOG4107RJ7 Glycosyl transferase (Group 1 FK536_RS00470 ENOG4107543 (lipo)polysaccharide FK536_RS00475 ENOG410650X lipopolysaccharide core region biosynthetic process FK536_RS00480 ENOG4107XU6 Glycosyl transferase (Group 1 FK536_RS00485 ENOG4106AH0 Glycosyl Transferase FK536_RS00490 ENOG4105X1N Glycosyl transferase family 8 FK536_RS00495 ENOG4108PDR lipopolysaccharide core biosynthesis protein FK536_RS00500 ENOG4108QD8 lipopolysaccharide core biosynthesis protein FK536_RS00505 ENOG4108XNZ glycosyl transferase FK536_RS00510 ENOG41068PG O-Antigen polymerase FK536_RS00515 ENOG4105D16 lipopolysaccharide heptosyltransferase i FK536_RS00520 ENOG4105XA0 heptosyltransferase ii FK536_RS00530 ENOG4108SEH involved in lipopolysaccharide biosynthesis FK536_RS00535 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FK536_RS00540 ENOG4105CPQ Dehydrogenase FK536_RS00545 ENOG4105K64 Glycosyl transferase, family 2 FK536_RS00550 ENOG4105PXI polysaccharide deacetylase FK536_RS00555 ENOG41063SB peptidase FK536_RS00560 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FK536_RS00565 ENOG4107YZP Rhodanese domain protein FK536_RS00570 ENOG4105VW4 glutaredoxin 3 FK536_RS00585 ENOG4105D7W serine acetyltransferase FK536_RS00590 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FK536_RS00600 ENOG41073TP transcriptional regulator FK536_RS00605 ENOG4105DAA L-lactate FK536_RS00610 ENOG4105EUR Domain-Containing protein FK536_RS00615 ENOG4108WY4 inner membrane lipoprotein FK536_RS00625 ENOG4108YYI Protein of unknown function (DUF2810) FK536_RS00635 ENOG4105E61 Mannitol repressor protein FK536_RS00645 ENOG4105CTS PTS system mannitol-specific FK536_RS00650 ENOG4105FP6 Protein of unknown function (DUF3302) FK536_RS00655 ENOG4105EFX secretion protein, HlyD family FK536_RS00675 ENOG4105NUP lyase containing HEAT-repeat FK536_RS00680 ENOG4105CNA YD repeat protein FK536_RS00685 ENOG4108U78 Glutathione S-transferase FK536_RS00695 ENOG4105EM7 Selenocysteine-specific translation elongation factor FK536_RS00700 ENOG4105C0A alcohol dehydrogenase FK536_RS00705 ENOG4105C26 Dehydrogenase FK536_RS00715 ENOG4105KK7 inner membrane protein YiaW FK536_RS00720 ENOG4105EFX secretion protein, HlyD family FK536_RS00725 ENOG4108Q2M Transcriptional regulator FK536_RS00730 ENOG4105GNX MltA-interacting MipA family protein FK536_RS00740 ENOG4105CT4 transporter FK536_RS00750 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FK536_RS00755 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase FK536_RS00760 ENOG4105H6Q decarboxylase FK536_RS00765 ENOG4105CMG Carbohydrate kinase FK536_RS00770 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FK536_RS00775 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FK536_RS00780 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FK536_RS00785 ENOG4108R66 Conserved Protein FK536_RS00795 ENOG4105J4Q Transcriptional regulator FK536_RS00800 ENOG4108XIB electron transport protein ysaA FK536_RS00805 ENOG4105JKW Valine--pyruvate aminotransferase FK536_RS00810 ENOG4107T9C Alpha amylase catalytic region FK536_RS00815 ENOG4108UR8 BAX protein FK536_RS00820 ENOG4105T16 Transcriptional regulator (AraC family) FK536_RS00825 ENOG4108HWW ABC transporter FK536_RS00830 ENOG4105C2J ABC transporter FK536_RS00835 ENOG4105DFW ABC transporter FK536_RS00840 ENOG4105C93 Xylose Isomerase FK536_RS00845 ENOG4105CMG Carbohydrate kinase FK536_RS00850 ENOG410688U Inner membrane protein yiaB FK536_RS00855 ENOG4108Z12 YiaAB two helix domain-containing protein FK536_RS00860 ENOG4105MEV Acyl-transferase FK536_RS00865 ENOG4105RGS lipoprotein ysaB FK536_RS00885 ENOG41060TC Hok gef cell toxic protein FK536_RS00895 ENOG4105MVF Transcriptional regulator FK536_RS00900 ENOG4106JH6 (LipO)protein FK536_RS00905 ENOG4105C5I Dehydrogenase FK536_RS00910 ENOG4108ZG0 Ompa motb domain protein FK536_RS00915 ENOG4107QY8 reductase FK536_RS00920 ENOG4105HNP -acetyltransferase FK536_RS00925 ENOG4108R3E Dna-3-methyladenine glycosylase i FK536_RS00930 ENOG4105EAX Putative lipase FK536_RS00935 ENOG4105FCD Major Facilitator FK536_RS00940 ENOG4105DIJ Phosphoethanolamine transferase FK536_RS00950 ENOG4105DEF Extracellular solute-binding protein, family 5 FK536_RS00955 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FK536_RS00960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FK536_RS00965 ENOG4105C3U ABC transporter FK536_RS00970 ENOG4108JQ7 (ABC) transporter FK536_RS00975 ENOG4105C44 Serine transporter FK536_RS00985 ENOG4105D1V cellulose synthase operon protein YhjU FK536_RS00990 ENOG4105WQA Cellulose biosynthesis protein BcsF FK536_RS01000 ENOG4107QZ7 Cellulose synthase catalytic subunit FK536_RS01005 ENOG4107EEX Cellulose synthase regulator protein FK536_RS01010 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FK536_RS01015 ENOG4105EJG cellulose synthase FK536_RS01020 ENOG4105BZU Histidine kinase FK536_RS01030 ENOG4105CS0 peptidase FK536_RS01035 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FK536_RS01040 ENOG4105CMB EAL domain-containing protein FK536_RS01045 ENOG41066T0 asmA family FK536_RS01050 ENOG4105CSH Transporter FK536_RS01055 ENOG4107H3J ribonuclease FK536_RS01060 ENOG4105CBN LysR family transcriptional regulator FK536_RS01065 ENOG4106S2D Transcriptional regulator FK536_RS01075 ENOG4105CA0 peroxidase FK536_RS01080 ENOG4105CVK Glutamate decarboxylase FK536_RS01090 ENOG4108NKV transcriptional regulator FK536_RS01100 ENOG4105BZS acriflavin resistance protein FK536_RS01105 ENOG4105C1P efflux transporter, rnd family, mfp subunit FK536_RS01115 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci FK536_RS01120 ENOG4108YK4 Acid-resistance membrane protein FK536_RS01125 ENOG41060V2 Acid-resistance protein FK536_RS01130 ENOG4105XXV Acid-resistance protein FK536_RS01135 ENOG4105KT7 mgtC SapB transporter FK536_RS01145 ENOG4105Y4Z Outer Membrane Lipoprotein FK536_RS01155 ENOG4105K89 arsenate reductase FK536_RS01160 ENOG4107R5R arsenical pump membrane protein FK536_RS01165 ENOG4105KBH arsR family transcriptional regulator FK536_RS01175 ENOG4105DC8 reductase FK536_RS01180 ENOG4105D6S protein involved in catabolism of external DNA FK536_RS01185 ENOG4105DGW oligopeptidase A FK536_RS01195 ENOG4105DUX Transporter FK536_RS01210 ENOG4105CJ3 phosphate transporter FK536_RS01215 ENOG4105CBX hi0933 family FK536_RS01220 ENOG4107UNS conserved inner membrane protein FK536_RS01235 ENOG4105D0S secretion protein (HlyD FK536_RS01240 ENOG4105CJ1 ABC, transporter FK536_RS01245 ENOG4105CMI transporter FK536_RS01250 ENOG410600T transposase FK536_RS01255 ENOG4105NUP lyase containing HEAT-repeat FK536_RS01265 ENOG4105CNA YD repeat protein FK536_RS01275 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FK536_RS01280 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FK536_RS01285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FK536_RS01290 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FK536_RS01295 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FK536_RS01300 ENOG4107YAK holo-(acyl carrier protein) synthase 2 FK536_RS01305 ENOG4105DSF transport protein FK536_RS01310 ENOG4105F9N Major Facilitator Superfamily FK536_RS01315 ENOG4108W1V Lipoprotein FK536_RS01320 ENOG4105EX9 Membrane FK536_RS01330 ENOG4105C59 p-type ATPase FK536_RS01335 ENOG4107FS9 Membrane FK536_RS01345 ENOG4105MG3 Membrane FK536_RS01350 ENOG4106H78 methyltransferase FK536_RS01355 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FK536_RS01360 ENOG4105CAK Cell division ATP-binding protein ftsE FK536_RS01365 ENOG4105CRP Part of the ABC transporter FtsEX involved in FK536_RS01370 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FK536_RS01375 ENOG4105CP9 extracellular ligand-binding receptor FK536_RS01380 ENOG4105U59 -acetyltransferase FK536_RS01385 ENOG4105CP9 extracellular ligand-binding receptor FK536_RS01390 ENOG4105C32 Amino acid ABC transporter (Permease) FK536_RS01395 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FK536_RS01400 ENOG4105C0Z ABC transporter FK536_RS01405 ENOG4108IV0 ABC, transporter FK536_RS01410 ENOG4105BZ7 extracellular solute-binding protein family 1 FK536_RS01415 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FK536_RS01420 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FK536_RS01425 ENOG4108IJ9 (ABC) transporter FK536_RS01430 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FK536_RS01435 ENOG4105WC8 Conserved Protein FK536_RS01440 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FK536_RS01445 ENOG4106FA4 FK536_RS01460 ENOG4105WCN acetyltransferase FK536_RS01465 ENOG4105D9R oxidoreductase FK536_RS01470 ENOG4105C2I pirin domain protein FK536_RS01475 ENOG4105DIQ Transcriptional regulator FK536_RS01480 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FK536_RS01485 ENOG4105C6Z Gluconate FK536_RS01490 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FK536_RS01495 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FK536_RS01520 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FK536_RS01530 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FK536_RS01545 ENOG4105E98 transcriptional regulator DeoR family FK536_RS01550 ENOG4105CYB regulatoR FK536_RS01555 ENOG4105E0Y RtcB Protein FK536_RS01560 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP FK536_RS01570 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FK536_RS01575 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FK536_RS01580 ENOG4105C6Z Gluconate FK536_RS01590 ENOG4105MJ2 Competence protein FK536_RS01595 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FK536_RS01600 ENOG4105DNE Transposase FK536_RS01610 ENOG4105CE1 Ferrous iron transport protein b FK536_RS01615 ENOG4105XFK Ferrous iron transport protein A FK536_RS01620 ENOG4105BZM domain protein FK536_RS01625 ENOG4108RRZ Transcription elongation factor GreB FK536_RS01635 ENOG4105E0F Histidine kinase FK536_RS01645 ENOG4108MAJ Membrane FK536_RS01655 ENOG4105VEJ Heat shock protein FK536_RS01660 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FK536_RS01665 ENOG4105DQY intracellular growth attenuator FK536_RS01670 ENOG4107RK2 ADP-ribose diphosphatase NudE FK536_RS01675 ENOG4108JQC penicillin-binding protein 1A FK536_RS01680 ENOG4108U1Q Pilus assembly protein FK536_RS01685 ENOG41065NF Fimbrial assembly family protein FK536_RS01690 ENOG4105XPX DNA utilization protein HofO FK536_RS01695 ENOG4105ITY Required for the use of extracellular DNA as a nutrient FK536_RS01710 ENOG4105D49 3-dehydroquinate synthase FK536_RS01715 ENOG4105EGB membrane protein DamX FK536_RS01720 ENOG4105DFE Dna adenine methylase FK536_RS01725 ENOG4105DJV ribulose-phosphate 3-epimerase FK536_RS01730 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FK536_RS01735 ENOG4105C31 Tryptophanyl-tRNA synthetase FK536_RS01740 ENOG4108M21 FK536_RS01750 ENOG4108626 Racemase FK536_RS01755 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FK536_RS01760 ENOG41080QX K07048 phosphotriesterase-related protein FK536_RS01765 ENOG4105MUZ Protein of unknown function DUF2620 FK536_RS01770 ENOG4106M0N transport system permease protein FK536_RS01775 ENOG4106PKC pyridoxal phosphate binding FK536_RS01780 ENOG4105FDP GntR family transcriptional regulator FK536_RS01785 ENOG4108KPW sugar kinase FK536_RS01790 ENOG4107Y0V Not clear, may be involved in an isomerization step FK536_RS01795 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine FK536_RS01800 ENOG4107QHQ amino acid FK536_RS01810 ENOG4105VYH FK536_RS01820 ENOG4107V9H nitrite transporter FK536_RS01825 ENOG4105WZK nitrite reductase NADPH small subunit FK536_RS01830 ENOG4107QZF nitrite reductase NADPH large subunit FK536_RS01840 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FK536_RS01850 ENOG4105MZU cell filamentation protein FK536_RS01855 ENOG4105DDQ anthranilate synthase FK536_RS01860 ENOG4105C8Y Acetylornithine aminotransferase FK536_RS01865 ENOG410613R integral membrane protein, YccS YhfK family FK536_RS01875 ENOG4108UKZ OsmC family FK536_RS01880 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FK536_RS01890 ENOG4105DNZ Alpha Beta Hydrolase FK536_RS01895 ENOG4105C5H ABC transporter FK536_RS01905 ENOG4105CKD glutathione-regulated potassium-efflux system protein FK536_RS01910 ENOG4105VKU nucleicacid-binding protein FK536_RS01915 ENOG4108YZY peptidylprolyl cis-trans isomerase FK536_RS01925 ENOG4108V1T peptidylprolyl cis-trans isomerase FK536_RS01930 ENOG4105WWK YheO domain protein FK536_RS01935 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) FK536_RS01940 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FK536_RS01945 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) FK536_RS01970 ENOG4108NNZ chitinase FK536_RS01975 ENOG4105W53 bacterioferritin-associated ferredoxin FK536_RS01980 ENOG4108UQY Iron-storage protein FK536_RS01985 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FK536_RS01995 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) FK536_RS02000 ENOG4105R04 type II secretion system protein K FK536_RS02015 ENOG41069X0 general secretion pathway protein h FK536_RS02020 ENOG4108VAU general secretion pathway protein G FK536_RS02025 ENOG4105D7Q type ii secretion system FK536_RS02030 ENOG4107QHF type ii secretion system protein e FK536_RS02035 ENOG4105GVR general secretion pathway protein D FK536_RS02040 ENOG4107KSE General secretion pathway protein C FK536_RS02045 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression FK536_RS02050 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication FK536_RS02070 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FK536_RS02115 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FK536_RS02160 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FK536_RS02165 ENOG41067V7 50S ribosomal protein L36 FK536_RS02195 ENOG4105VTS DnaJ-like, subfamily C FK536_RS02200 ENOG4105W1Y Transcriptional regulator FK536_RS02205 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system FK536_RS02215 ENOG4105C1A potassium transporter peripheral membrane FK536_RS02235 ENOG4105C79 DNA protecting protein DprA FK536_RS02245 ENOG4108WI1 Dna topoisomerase FK536_RS02260 ENOG4105SG3 Protein of unknown function (DUF1488) FK536_RS02265 ENOG4108Z0R Transferase FK536_RS02310 ENOG4105CDA abc transporter atp-binding protein FK536_RS02315 ENOG4105DRP amino acid AbC transporter FK536_RS02320 ENOG4105EZ7 amino acid ABC transporter FK536_RS02330 ENOG4105XCM membrane LIPOPROTEIN FK536_RS02340 ENOG4105BZS acriflavin resistance protein FK536_RS02345 ENOG4105C1P efflux transporter, rnd family, mfp subunit FK536_RS02350 ENOG4108XG4 DNA-binding transcriptional regulator FK536_RS02355 ENOG41061ME transport protein FK536_RS02360 ENOG4105CEC DNA methylase N-4 N-6 FK536_RS02370 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FK536_RS02380 ENOG4108IA2 Sodium pantothenate symporter FK536_RS02385 ENOG4105RG0 Membrane FK536_RS02390 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FK536_RS02395 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FK536_RS02400 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FK536_RS02405 ENOG41062P1 Diguanylate cyclase phosphodiesterase FK536_RS02415 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FK536_RS02420 ENOG4105VQ7 Rod shape-determining protein MreD FK536_RS02425 ENOG4108Z03 MAF-like protein FK536_RS02430 ENOG4105C03 ribonuclease FK536_RS02435 ENOG4105QD6 exported protein FK536_RS02440 ENOG4105D1U peptidase U62 modulator of DNA gyrase FK536_RS02445 ENOG4105CR8 Transcriptional regulator FK536_RS02450 ENOG4105ZQC membrane protein AaeX FK536_RS02465 ENOG4105UNR (Barnase) inhibitor FK536_RS02470 ENOG4105RID UPF0379 protein yhcN FK536_RS02485 ENOG4105C0H protease FK536_RS02490 ENOG4105C0H protease FK536_RS02495 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FK536_RS02500 ENOG4105D6Z AFG1 family ATPase FK536_RS02515 ENOG4107MKT Stringent starvation protein a FK536_RS02520 ENOG4105KB2 stringent starvation protein b FK536_RS02525 ENOG4105CEE C4-dicarboxylate transporter FK536_RS02530 ENOG4108QBF Transcriptional regulator FK536_RS02540 ENOG4105JHE Major Facilitator Superfamily FK536_RS02550 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) FK536_RS02555 ENOG4108R66 Conserved Protein FK536_RS02560 ENOG4105DFS Conserved Protein FK536_RS02590 ENOG4105E6S usher protein( FK536_RS02595 ENOG4108S1B Periplasmic chaperone protein FK536_RS02600 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon FK536_RS02605 ENOG4105BZ8 glutamate synthase FK536_RS02610 ENOG4105CBC glutamate synthase FK536_RS02615 ENOG4105N5T Radical SAM Protein FK536_RS02620 ENOG4105BZU Histidine kinase FK536_RS02625 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FK536_RS02635 ENOG4108NIH transferase activity, transferring phosphorus-containing groups FK536_RS02640 ENOG41080Z8 PHOSPHOCARRIER protein FK536_RS02650 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FK536_RS02655 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FK536_RS02660 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FK536_RS02665 ENOG4108IUZ ABC transporter FK536_RS02670 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FK536_RS02675 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) FK536_RS02680 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FK536_RS02685 ENOG4105C2X Arabinose 5-phosphate isomerase FK536_RS02690 ENOG4105FEU K -dependent Na -Ca exchanger FK536_RS02695 ENOG4105DHJ ABC, transporter FK536_RS02700 ENOG4105CY3 ABC transporter, permease FK536_RS02705 ENOG4107PE3 Mammalian cell entry related domain protein FK536_RS02710 ENOG4105E3I toluene tolerance FK536_RS02715 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane FK536_RS02720 ENOG4105VFK BolA family FK536_RS02730 ENOG4105HVQ Regulatory factor of maltose metabolism FK536_RS02735 ENOG4105EAH synthase FK536_RS02750 ENOG4105QYV Membrane FK536_RS02755 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FK536_RS02760 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FK536_RS02765 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FK536_RS02770 ENOG4105HBR Rna-binding protein FK536_RS02780 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FK536_RS02785 ENOG4105EEI dihydropteroate synthase FK536_RS02795 ENOG4105NTZ Preprotein translocase subunit SecG FK536_RS02810 ENOG4105DIJ Phosphoethanolamine transferase FK536_RS02830 ENOG4105CHV Transcription elongation factor NusA FK536_RS02870 ENOG4105C1J atp-dependent rna helicase FK536_RS02875 ENOG4105CIC tryptophan-specific transport protein FK536_RS02880 ENOG4105DEN Luciferase family FK536_RS02900 ENOG4108YYD acetyltransferase FK536_RS02905 ENOG41082IR Excinuclease ABC C subunit domain protein FK536_RS02915 ENOG4107R7Y intracellular protease Pfpi family FK536_RS02920 ENOG4105K4T epimerase FK536_RS02925 ENOG4107S21 permease FK536_RS02930 ENOG4105W4M Transport-associated protein FK536_RS02940 ENOG41082RQ UPF0102 protein FK536_RS02945 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FK536_RS02950 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FK536_RS02955 ENOG4105I74 Fimbrial protein FK536_RS02960 ENOG4105CW0 outer membrane usher protein FK536_RS02965 ENOG4108VCD Chaperone FK536_RS02970 ENOG4105Q10 Fimbrial-like protein FK536_RS02975 ENOG4106HBN Galactosamine-6-phosphate isomerase FK536_RS02980 ENOG4105F3R pts system mannose fructose sorbose family iid FK536_RS02985 ENOG4105ETZ PTS System FK536_RS02990 ENOG4108UZY PTS System FK536_RS03000 ENOG4105E70 isomerase FK536_RS03005 ENOG4105CE4 GlcNAc 6-P deacetylase FK536_RS03010 ENOG4108YTN IIa component FK536_RS03015 ENOG4105F3R pts system mannose fructose sorbose family iid FK536_RS03025 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB FK536_RS03030 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of FK536_RS03035 ENOG4105E98 transcriptional regulator DeoR family FK536_RS03040 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression FK536_RS03045 ENOG4105ZEG Suppressor protein FK536_RS03050 ENOG4105CTX dehydratase FK536_RS03055 ENOG4105DJB Major Facilitator Superfamily FK536_RS03065 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FK536_RS03070 ENOG4105BZW Glycerate kinase FK536_RS03095 ENOG410811B TRANSCRIPTIONal FK536_RS03100 ENOG4105C7B Threonine dehydratase FK536_RS03110 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FK536_RS03115 ENOG4105C6N Formate acetyltransferase FK536_RS03120 ENOG4105KME endoribonuclease L-psp FK536_RS03125 ENOG4105EJQ L-serine dehydratase FK536_RS03130 ENOG4105C44 Serine transporter FK536_RS03135 ENOG4105CEM UPF0597 protein FK536_RS03140 ENOG4106D80 Uncharacterized protein YhaL FK536_RS03145 ENOG4108CNN domain protein FK536_RS03150 ENOG4105CWB LysR family transcriptional Regulator FK536_RS03155 ENOG4105KAF membrAne FK536_RS03160 ENOG4105KAF membrAne FK536_RS03165 ENOG4105CHF Glutathione S-transferase FK536_RS03170 ENOG4108VBZ doxx family FK536_RS03175 ENOG4105YJD FK536_RS03180 ENOG41090KG Inner membrane protein YqjE FK536_RS03185 ENOG4105NE1 Conserved Protein FK536_RS03190 ENOG4105WAY exported protein FK536_RS03195 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) FK536_RS03200 ENOG4106W5V Membrane FK536_RS03205 ENOG4107YCY Transcriptional regulator FK536_RS03210 ENOG4105DPW Major facilitator superfamily MFS_1 FK536_RS03220 ENOG4105CTX dehydratase FK536_RS03225 ENOG4105P66 Membrane FK536_RS03230 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FK536_RS03235 ENOG4105DU1 integral membrane protein, terc FK536_RS03240 ENOG4105EE0 oxidoreductase FK536_RS03245 ENOG4108UB4 uncharacterized protein ygjQ FK536_RS03250 ENOG4108VKG metal-dependent hydrolase FK536_RS03255 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FK536_RS03260 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase FK536_RS03265 ENOG4108Z3N Transcriptional regulator FK536_RS03270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FK536_RS03275 ENOG4107WCA isomerase FK536_RS03280 ENOG4107W6W Conserved Protein FK536_RS03285 ENOG4105E5D amino acid FK536_RS03290 ENOG4105FK9 beta-D-galactosidase beta subunit FK536_RS03295 ENOG4105CNT hydrolase family 2 FK536_RS03300 ENOG4105CQ4 Transcriptional regulator FK536_RS03305 ENOG4108Y51 tRNA-binding protein FK536_RS03310 ENOG4105C8Y Acetylornithine aminotransferase FK536_RS03315 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FK536_RS03320 ENOG4105NTW Transcriptional regulator FK536_RS03325 ENOG4105Q26 Siderophore-interacting protein FK536_RS03340 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FK536_RS03345 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FK536_RS03355 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FK536_RS03360 ENOG4107QPK )-transporter FK536_RS03365 ENOG4107GFK fumarate FK536_RS03370 ENOG4106DSS Tartrate dehydratase subunit alpha FK536_RS03375 ENOG4105EJC lysr family transcriptional regulator FK536_RS03385 ENOG4107ZVW dihydroneopterin aldolase FK536_RS03400 ENOG4106MWK domain protein FK536_RS03405 ENOG4105I7R Adenylate cyclase FK536_RS03410 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) FK536_RS03430 ENOG4107S78 Band 7 protein FK536_RS03435 ENOG4105PV3 Inner membrane protein yqiJ FK536_RS03445 ENOG4108MY7 Fimbrial FK536_RS03450 ENOG4108TTM chaperone FK536_RS03460 ENOG4105H8W Fimbrial protein FK536_RS03465 ENOG4105W0Z cytoplasmic protein FK536_RS03485 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FK536_RS03490 ENOG4106032 Glutathionylspermidine synthase FK536_RS03500 ENOG4105DFG type I secretion outer membrane protein FK536_RS03505 ENOG41087AY ADP-Ribose pyrophosphatase FK536_RS03510 ENOG4108SX3 cytoplasmic protein FK536_RS03515 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FK536_RS03520 ENOG4105IPS esterase FK536_RS03525 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FK536_RS03530 ENOG4105VRH Antibiotic biosynthesis monooxygenase FK536_RS03535 ENOG4105NF4 modulator of drug activity FK536_RS03540 ENOG4107DEU Inner membrane protein YgiZ FK536_RS03545 ENOG4105DHQ Histidine kinase FK536_RS03550 ENOG4105XJC Two component transcriptional regulator (Winged helix family FK536_RS03555 ENOG4105H4F exported protein FK536_RS03560 ENOG4105F4I Transcriptional regulator FK536_RS03565 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation FK536_RS03570 ENOG4105WJ3 XRE family Transcriptional regulator FK536_RS03575 ENOG4108J59 Extracellular solute-binding protein, family 5 FK536_RS03580 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FK536_RS03585 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FK536_RS03590 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) FK536_RS03595 ENOG4105CCT upf0313 protein FK536_RS03605 ENOG4105ZKC Conserved Protein FK536_RS03610 ENOG4105CV8 reductase FK536_RS03615 ENOG4108I6A alcohol dehydrogenase FK536_RS03620 ENOG4105CF7 AraC family transcriptional regulator FK536_RS03625 ENOG4108K81 inner membrane protein YghB FK536_RS03630 ENOG4105C28 cystathionine FK536_RS03635 ENOG4105CWK Biopolymer transport protein, ExbB FK536_RS03640 ENOG4108ZZF transport protein (ExbD) FK536_RS03645 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FK536_RS03655 ENOG4105CPC Aldo Keto reductase FK536_RS03665 ENOG410900S Protein of unknown function (DUF2623) FK536_RS03670 ENOG4105E3S small subunit FK536_RS03675 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FK536_RS03680 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit FK536_RS03685 ENOG4105DPX Hydrogenase, large subunit FK536_RS03690 ENOG4108USZ hydrogenase FK536_RS03695 ENOG4108WGS hydrogenase 2-specific chaperone FK536_RS03705 ENOG41082MF Hydrogenase assembly chaperone hypC hupF FK536_RS03710 ENOG4105CYM Glutathione S-transferase FK536_RS03715 ENOG4106032 Glutathionylspermidine synthase FK536_RS03725 ENOG4108GH0 ATP-binding protein yghT FK536_RS03730 ENOG4108NDC ATP-binding protein yghS FK536_RS03735 ENOG4106FPV ATP-binding protein YghR FK536_RS03740 ENOG4108S55 polysaccharide biosynthesis protein FK536_RS03750 ENOG4108UUE Transcriptional regulator FK536_RS03755 ENOG4108M8S permease YjgP YjgQ family protein FK536_RS03765 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FK536_RS03770 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FK536_RS03780 ENOG4107RCI amp-dependent synthetase and ligase FK536_RS03790 ENOG4108KWP DNA-binding transcriptional regulator GlcC FK536_RS03795 ENOG4105CQB FAD linked oxidase domain protein FK536_RS03800 ENOG4105EU8 FAD linked oxidase domain protein FK536_RS03805 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FK536_RS03810 ENOG4108ZJF Glcg protein FK536_RS03815 ENOG4107QP3 malate synthase g FK536_RS03820 ENOG4105DAA L-lactate FK536_RS03870 ENOG4105D5Q Arginine ornithine antiporter FK536_RS03885 ENOG4105PV3 Inner membrane protein yqiJ FK536_RS03895 ENOG4108MY7 Fimbrial FK536_RS03900 ENOG4108TTM chaperone FK536_RS03915 ENOG41060ND LF82 chromosome, complete sequence FK536_RS03950 ENOG4108KZE transcriptional regulator FK536_RS03955 ENOG4108QDQ Ubiquinol-cytochrome C chaperone FK536_RS03990 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FK536_RS04020 ENOG4108UQV Membrane FK536_RS04025 ENOG4105CXN decarboxylase FK536_RS04030 ENOG4105EAA nucleoside FK536_RS04045 ENOG4105CEN a g-specific adenine glycosylase FK536_RS04055 ENOG41090ED Protein with unknown function (DUF469) FK536_RS04060 ENOG4105K33 Periplasmic Protein FK536_RS04065 ENOG4105HDK L-asparaginase FK536_RS04070 ENOG4106MH3 alpha helix chain FK536_RS04075 ENOG4105CSA Coproporphyrinogen iii oxidase FK536_RS04080 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FK536_RS04090 ENOG4108VIA integral membrane protein FK536_RS04095 ENOG4105DFA alanine racemase domain protein FK536_RS04100 ENOG4105CZX twitching motility protein FK536_RS04115 ENOG4105D7Z glutathione synthase FK536_RS04120 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FK536_RS04125 ENOG4105RWS endonuclease I FK536_RS04135 ENOG4107QNK )-transporter FK536_RS04160 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FK536_RS04170 ENOG4108K0D peptidase, M48 FK536_RS04175 ENOG4105CV1 Transketolase (EC 2.2.1.1) FK536_RS04180 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FK536_RS04185 ENOG4105CTS PTS system mannitol-specific FK536_RS04190 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FK536_RS04195 ENOG4108Q8A Fructose-1,6-bisphosphatase FK536_RS04200 ENOG4108R4K DNA-binding, transcriptional regulator FK536_RS04205 ENOG4107Z1W Fructose transport system kinase FK536_RS04220 ENOG4105D2N Aldolase FK536_RS04225 ENOG4105D64 Mechanosensitive ion channel FK536_RS04230 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FK536_RS04235 ENOG4105MPN Membrane FK536_RS04240 ENOG4105DEQ transcriptional regulator FK536_RS04245 ENOG4105CYC Transferase FK536_RS04250 ENOG4108M7F enoyl-CoA hydratase isomerase FK536_RS04255 ENOG4105DJT lAO AO transport system ATPase FK536_RS04260 ENOG4105D5P Methylmalonyl-coA mutase FK536_RS04280 ENOG4108JQ1 Dehydrogenase FK536_RS04290 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FK536_RS04310 ENOG4107RAQ aminopeptidase FK536_RS04315 ENOG4105D0A hydroxylase FK536_RS04320 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FK536_RS04350 ENOG4105CS2 ec 3.2.1.21 FK536_RS04355 ENOG4105N5Z UPF0267 protein FK536_RS04360 ENOG4108UT2 hemolysin iii FK536_RS04370 ENOG4105Y75 tpr repeat protein FK536_RS04375 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB FK536_RS04380 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FK536_RS04385 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FK536_RS04390 ENOG4105T95 Thiol disulfide interChange protein FK536_RS04395 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FK536_RS04405 ENOG4105CRK lysyL-tRNA synthetase FK536_RS04425 ENOG4105C2W permease FK536_RS04430 ENOG4105BZ8 glutamate synthase FK536_RS04435 ENOG4108R8B oxidoreductase Fe-S subunit FK536_RS04440 ENOG4105C7N Xanthine uracil vitamin C permease FK536_RS04445 ENOG4107QUY Guanine deaminase FK536_RS04450 ENOG4105C2W permease FK536_RS04455 ENOG4105C7W Xanthine dehydrogenase FK536_RS04460 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase FK536_RS04465 ENOG4107UUR Chlorohydrolase aminohydrolase FK536_RS04470 ENOG4105BZ8 glutamate synthase FK536_RS04475 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase FK536_RS04480 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC FK536_RS04485 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family FK536_RS04490 ENOG4105C5B carbamate kinase FK536_RS04500 ENOG4107S4Y M20 DapE family protein YgeY FK536_RS04505 ENOG4107RCH Diaminopropionate ammonia-lyase FK536_RS04510 ENOG4105IW6 Carbamoyltransferase FK536_RS04515 ENOG4108JUB Transcriptional regulator FK536_RS04520 ENOG4108UTP (2Fe-2S)-binding domain protein FK536_RS04525 ENOG4108HR6 Dehydrogenase FK536_RS04530 ENOG4105C7W Xanthine dehydrogenase FK536_RS04535 ENOG4108K5P (LipO)protein FK536_RS04555 ENOG41075IY surface presentation of antigens protein SpaP FK536_RS04560 ENOG4105U07 type iii secretion FK536_RS04565 ENOG4108TN6 type iii secretion FK536_RS04570 ENOG4108M6W surface presentation of antigens protein SpaS FK536_RS04575 ENOG4108M6W surface presentation of antigens protein SpaS FK536_RS04590 ENOG4105ISV protein with bipartite regulator domain FK536_RS04595 ENOG4108MHD transport protein FK536_RS04600 ENOG4105CHU acetyl-coa acetyltransferase FK536_RS04610 ENOG4105CHR reductase FK536_RS04615 ENOG4107QNK )-transporter FK536_RS04625 ENOG4105RQF LysR family Transcriptional regulator FK536_RS04635 ENOG41060NJ transcriptional regulator FK536_RS04640 ENOG4105CEY Amp-dependent synthetase and ligase FK536_RS04645 ENOG4107S74 Lysophospholipid transporter LplT FK536_RS04650 ENOG4105CPC Aldo Keto reductase FK536_RS04655 ENOG4105SUV lipoprotein YgdR FK536_RS04660 ENOG4105EE5 Membrane protein terC FK536_RS04675 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FK536_RS04690 ENOG4105IPU prepilin peptidase dependent protein A FK536_RS04695 ENOG4105JCS prepilin peptidase dependent protein FK536_RS04700 ENOG4105SEN Protein of unknown function (DUF2509) FK536_RS04705 ENOG4105RVB Prepilin peptidase dependent protein c FK536_RS04710 ENOG4105DSY exodeoxyribonuclease V, gamma FK536_RS04715 ENOG4107QXK peptidase FK536_RS04720 ENOG4107QKA exodeoxyribonuclease V beta FK536_RS04725 ENOG4107QYX exodeoxyribonuclease v alpha FK536_RS04730 ENOG4108EKC n-acetylglutamate synthase FK536_RS04735 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FK536_RS04755 ENOG4105CA3 membrane-bound lytic murein transglycosylase FK536_RS04760 ENOG4105CUZ uba thif-type nad fad binding protein FK536_RS04765 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FK536_RS04770 ENOG4105C9B Cysteine desulfurase FK536_RS04775 ENOG4105M5B (LipO)protein FK536_RS04780 ENOG4105ETT transcriptional Regulator, LysR family FK536_RS04785 ENOG4105M08 Membrane FK536_RS04795 ENOG4107EDW L-fucose operon activator FK536_RS04805 ENOG4105CMG Carbohydrate kinase FK536_RS04810 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) FK536_RS04820 ENOG4107W7X Aldolase FK536_RS04825 ENOG4105C0A alcohol dehydrogenase FK536_RS04835 ENOG4105EJQ L-serine dehydratase FK536_RS04840 ENOG4105C44 Serine transporter FK536_RS04845 ENOG4105EWT decarboxylase family FK536_RS04860 ENOG4105WP7 tRNA pseudouridine synthase C FK536_RS04865 ENOG4105DR9 pseudouridine synthase FK536_RS04870 ENOG4105QDK Flavodoxin FK536_RS04875 ENOG4105DJB Major Facilitator Superfamily FK536_RS04880 ENOG4105EQX glucarate dehydratase FK536_RS04885 ENOG4105EQX glucarate dehydratase FK536_RS04890 ENOG4105BZU Histidine kinase FK536_RS04900 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FK536_RS04905 ENOG4106A2Z transcriptional regulator antitoxin, MazE FK536_RS04910 ENOG4105MZG transcriptional modulator of maze toxin, mazf FK536_RS04915 ENOG4105DXN mazG family FK536_RS04930 ENOG4105HA9 of methanol dehydrogenase type FK536_RS04940 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FK536_RS04945 ENOG4108CWB sugar kinase ygcE FK536_RS04950 ENOG4108ITV Inner membrane protein yqcE FK536_RS04955 ENOG4105CHR reductase FK536_RS04960 ENOG4107R3A FAD linked oxidase domain protein FK536_RS04965 ENOG4105C54 Major Facilitator superfamily FK536_RS04970 ENOG4106IKH Electron transfer flavoprotein FK536_RS04975 ENOG4105YBM electron transfer flavoprotein subunit ygcQ FK536_RS04980 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FK536_RS04985 ENOG4105WQV ferredoxin-like protein FK536_RS04990 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FK536_RS04995 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FK536_RS05005 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FK536_RS05015 ENOG4107635 Hok Gef family protein FK536_RS05020 ENOG4108SER Transposase FK536_RS05030 ENOG4105PWE CRISPR-associated protein cas2 FK536_RS05035 ENOG4108MXK alkaline phosphatase isozyme conversion FK536_RS05040 ENOG4105C11 sulfate adenylyltransferase), subunit 2 FK536_RS05055 ENOG4105N0Z inner membrane protein ygbE FK536_RS05090 ENOG4108K5P (LipO)protein FK536_RS05095 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FK536_RS05100 ENOG4105C6Z Gluconate FK536_RS05105 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FK536_RS05110 ENOG4105FB2 class II Aldolase FK536_RS05115 ENOG4105G63 Type III effector Hrp-dependent FK536_RS05120 ENOG4105ZXK Dehydrogenase FK536_RS05125 ENOG4105MVE transcriptional regulator FK536_RS05130 ENOG4105MEW serine threonine protein phosphatase FK536_RS05145 ENOG4105VXR cytoplasmic protein FK536_RS05150 ENOG4108JUA Transcriptional regulator FK536_RS05155 ENOG4105C45 hydrogenase expression formation protein (HypE) FK536_RS05160 ENOG4105CQS hydrogenase expression formation protein HypD FK536_RS05165 ENOG41083WG hydrogenase assembly chaperone FK536_RS05170 ENOG4107RSS Hydrogenase accessory protein HypB FK536_RS05175 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FK536_RS05180 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA FK536_RS05185 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) FK536_RS05190 ENOG4107R30 NADH dehydrogenase FK536_RS05195 ENOG4107TDF Formate hydrogenlyase subunit 4 FK536_RS05200 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FK536_RS05205 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit FK536_RS05210 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FK536_RS05215 ENOG4105I6X formate hydrogenlyase maturation FK536_RS05220 ENOG4108MG9 hydrogenase 3 maturation protease FK536_RS05225 ENOG4105CS2 ec 3.2.1.21 FK536_RS05230 ENOG4105C5Y PTS System FK536_RS05235 ENOG4105DDV Transcriptional regulator (LacI family FK536_RS05240 ENOG4108RC0 Electron transport protein FK536_RS05245 ENOG4105C8H hydrogenase maturation protein Hypf FK536_RS05250 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase FK536_RS05260 ENOG4108JUA Transcriptional regulator FK536_RS05265 ENOG4105C2X Arabinose 5-phosphate isomerase FK536_RS05270 ENOG410804X Transcriptional regulator FK536_RS05275 ENOG4105J92 DNA-binding transcriptional activator GutM FK536_RS05280 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase FK536_RS05285 ENOG4105VI0 Pts system, glucitol sorbitol-specific FK536_RS05290 ENOG4105DZY Pts system, glucitol sorbitol-specific FK536_RS05295 ENOG410787A Pts system, glucitol sorbitol-specific FK536_RS05300 ENOG4105CVE Lytic murein transglycosylase FK536_RS05305 ENOG4107TH8 cina domain protein FK536_RS05320 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FK536_RS05325 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FK536_RS05355 ENOG4107VXZ Hydrolase FK536_RS05360 ENOG4105W39 Membrane FK536_RS05375 ENOG4105C0R drug resistance transporter emrb qaca subfamily FK536_RS05380 ENOG4105CW7 secretion protein, HlyD family FK536_RS05385 ENOG4105NTK Transcriptional repressor Mpra FK536_RS05395 ENOG4105ZED uncharacterized protein ygaH FK536_RS05400 ENOG4108UMN azlc family FK536_RS05410 ENOG4105GIJ Glycine betaine FK536_RS05415 ENOG4108HQS Glycine betaine FK536_RS05420 ENOG4108IJ7 Glycine betaine FK536_RS05425 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FK536_RS05430 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FK536_RS05440 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FK536_RS05445 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) FK536_RS05450 ENOG4108WMJ Protein of unknown function (DUF2002) FK536_RS05455 ENOG4108RNS Exports L-alanine (By similarity) FK536_RS05460 ENOG4108X73 DNA- binding protein FK536_RS05465 ENOG4108V62 Rhodanese domain protein FK536_RS05470 ENOG41080HT Transcriptional regulator, arsr family FK536_RS05475 ENOG4105VPI YqaE family transport protein FK536_RS05480 ENOG4109066 lysm domain bon superfamily protein FK536_RS05485 ENOG4108PVQ transcriptional regulator FK536_RS05490 ENOG4105C85 amino acid FK536_RS05495 ENOG4108JPW Aminotransferase FK536_RS05500 ENOG4105C26 Dehydrogenase FK536_RS05505 ENOG4105D5U fad dependent oxidoreductase FK536_RS05510 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) FK536_RS05520 ENOG4105E54 alpha-amylase FK536_RS05545 ENOG4108MGN ATP-binding component of a transport system FK536_RS05595 ENOG4105FA0 parb-like partition protein FK536_RS05610 ENOG4105DFP Integrase FK536_RS05625 ENOG4108Z1B Cyclase dehydrase FK536_RS05635 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FK536_RS05640 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FK536_RS05655 ENOG4108JU6 CBS domain protein FK536_RS05660 ENOG4106KVJ cytochrome C assembly protein FK536_RS05665 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FK536_RS05690 ENOG41090EK ompa motb domain protein FK536_RS05695 ENOG4108KHX Diguanylate cyclase FK536_RS05700 ENOG4108WS1 FK536_RS05705 ENOG4105QP9 Protein of unknown function (DUF2799) FK536_RS05710 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FK536_RS05715 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FK536_RS05720 ENOG4105CQC Prephenate dehydratase FK536_RS05730 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FK536_RS05775 ENOG4105ED4 portal protein FK536_RS05875 ENOG410685N tail fiber protein FK536_RS05880 ENOG4105UZW Tail fiber assembly protein FK536_RS05905 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FK536_RS05910 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FK536_RS05915 ENOG4105C34 Pseudouridine synthase FK536_RS05920 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FK536_RS05925 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FK536_RS05950 ENOG4105CSH Transporter FK536_RS05955 ENOG4105T42 (LipO)protein FK536_RS05960 ENOG4105JIM Phosphatidylserine synthase FK536_RS05965 ENOG4105CD5 CoA-binding domain protein FK536_RS05970 ENOG4106IUH DTW domain containing protein FK536_RS05975 ENOG4105K63 Thioredoxin FK536_RS05980 ENOG4105EIB trna rrna methyltransferase FK536_RS06000 ENOG41090KR LysR family transcriptional Regulator FK536_RS06005 ENOG4105C1J atp-dependent rna helicase FK536_RS06015 ENOG4108IYU L-aspartate oxidase FK536_RS06025 ENOG4105EMN RNA polymerase sigma factor FK536_RS06030 ENOG41069PW sigma-e factor negative regulatory protein FK536_RS06035 ENOG4105VQK sigma E regulatory protein, MucB RseB FK536_RS06040 ENOG4105WMJ Positive regulator of sigma E, RseC MucC FK536_RS06050 ENOG4105C3F Signal peptidase i FK536_RS06070 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FK536_RS06085 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FK536_RS06090 ENOG4106G6Q Transcriptional regulator FK536_RS06095 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB FK536_RS06100 ENOG4108Z6B deaminase FK536_RS06115 ENOG4107WP9 Histidine kinase FK536_RS06120 ENOG4108SKK alpha helix protein FK536_RS06125 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FK536_RS06135 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FK536_RS06145 ENOG4108NZE NAGC-like transcriptional regulator FK536_RS06150 ENOG4107HQ7 repeat protein FK536_RS06155 ENOG4105FCA ABC transporter periplasmic-binding protein YphF FK536_RS06160 ENOG4108F37 ATP-binding component of a transport system FK536_RS06165 ENOG4105CNN ABC, transporter FK536_RS06170 ENOG4105CPQ Dehydrogenase FK536_RS06175 ENOG4108ZKT aldose 1-epimerase FK536_RS06180 ENOG4108SB3 DoxX Family FK536_RS06190 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase FK536_RS06205 ENOG4105FUY alpha subunit FK536_RS06210 ENOG4108W5M transcriptional regulator FK536_RS06215 ENOG4105D8G Major Facilitator superfamily FK536_RS06220 ENOG4108MN2 Stationary phase inducible protein CsiE FK536_RS06225 ENOG4107XM9 (LipO)protein FK536_RS06230 ENOG4105ECY inositol monophosphatase FK536_RS06250 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FK536_RS06270 ENOG4108ZIT Ferredoxin, 2FE-2S FK536_RS06275 ENOG4105WVQ Fe-S assembly protein IscX FK536_RS06280 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FK536_RS06285 ENOG4105YYA enhanced serine sensitivity protein SseB FK536_RS06290 ENOG4105KHC sulfurtransferase FK536_RS06295 ENOG4105DN3 alpha-2-macroglobulin domain protein FK536_RS06300 ENOG4108JQB penicillin-binding protein 1C FK536_RS06330 ENOG4105N21 Membrane FK536_RS06345 ENOG4105VPD cellular component movement FK536_RS06350 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FK536_RS06355 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FK536_RS06360 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FK536_RS06365 ENOG41066DY Membrane FK536_RS06370 ENOG4108ZMA Outer membrane lipoprotein FK536_RS06375 ENOG41062G3 Protein of unknown function (DUF2633) FK536_RS06395 ENOG4105C9X ppx gppa phosphatase FK536_RS06400 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FK536_RS06405 ENOG4108V3E phosphoribosylglycinamide formyltransferase FK536_RS06410 ENOG4105CXB phosphoribosylaminoimidazole synthetase FK536_RS06420 ENOG4105C2W permease FK536_RS06425 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) FK536_RS06430 ENOG4105K89 arsenate reductase FK536_RS06435 ENOG4105ERG peptidase m48, ste24p FK536_RS06440 ENOG4105C02 permease FK536_RS06445 ENOG4105TMB Formate nitrite transporter FK536_RS06450 ENOG4108JUA Transcriptional regulator FK536_RS06455 ENOG4105I6X formate hydrogenlyase maturation FK536_RS06460 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FK536_RS06470 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FK536_RS06475 ENOG4108JPZ Monovalent cation H antiporter subunit D FK536_RS06480 ENOG4107WQX hydrogenase 4 membrane subunit FK536_RS06485 ENOG4105D65 subunit l FK536_RS06490 ENOG4107TDF Formate hydrogenlyase subunit 4 FK536_RS06500 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) FK536_RS06505 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FK536_RS06510 ENOG4105RH4 Glycine cleavage system transcriptional repressor FK536_RS06520 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FK536_RS06530 ENOG4105CGZ zinc metallopeptidase FK536_RS06535 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FK536_RS06540 ENOG4106KED esterase YpfH FK536_RS06555 ENOG4105KUZ arsenate reductase FK536_RS06565 ENOG4105BZS acriflavin resistance protein FK536_RS06570 ENOG4105BZU Histidine kinase FK536_RS06575 ENOG4105BZ8 glutamate synthase FK536_RS06585 ENOG4108PVD exported protein FK536_RS06590 ENOG4105CV1 Transketolase (EC 2.2.1.1) FK536_RS06595 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FK536_RS06600 ENOG4105C6K Malic enzyme FK536_RS06605 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place FK536_RS06610 ENOG4106S4J ethanolamine utilization protein EutP FK536_RS06615 ENOG4105NDK ethanolamine utilization protein FK536_RS06620 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase FK536_RS06625 ENOG4107WUY phosphate acetyltransferase FK536_RS06630 ENOG4105KNY Microcompartments protein FK536_RS06635 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FK536_RS06640 ENOG4108EKI Dehydrogenase FK536_RS06645 ENOG4107RWI ethanolamine utilization protein eutJ FK536_RS06650 ENOG4105C0A alcohol dehydrogenase FK536_RS06655 ENOG4105ENY Ethanolamine utilization protein eutH FK536_RS06660 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase FK536_RS06665 ENOG4105CPD ethanolamine ammonia-lyase FK536_RS06675 ENOG4106D67 ethanolamine utilization protein FK536_RS06680 ENOG4108X49 Ethanolamine utilization protein EutK FK536_RS06685 ENOG4108K3Z AraC family transcriptional regulator FK536_RS06695 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FK536_RS06700 ENOG4108R6G acetyltransferase FK536_RS06705 ENOG4105QZU Inner membrane protein YfeZ FK536_RS06710 ENOG4105E7K (LipO)protein FK536_RS06715 ENOG4105EZR dyp-type peroxidase family protein FK536_RS06720 ENOG4107S1E Beta-lactamase FK536_RS06725 ENOG4105C5Y PTS System FK536_RS06735 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) FK536_RS06740 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FK536_RS06745 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein FK536_RS06750 ENOG4108I5D sulfate abc transporter FK536_RS06755 ENOG4105ECW sulfate abc transporter FK536_RS06760 ENOG4108IJ6 ABC transporter FK536_RS06765 ENOG4105C6T cysteine synthase FK536_RS06770 ENOG4105WEC Molybdate metabolism regulator FK536_RS06775 ENOG4105M0Y FK536_RS06785 ENOG4105C5Y PTS System FK536_RS06790 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FK536_RS06800 ENOG4105C6T cysteine synthase FK536_RS06815 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FK536_RS06820 ENOG4105VRT cytoplasmic protein FK536_RS06825 ENOG4105DHU Bile acid FK536_RS06830 ENOG4108M0I Transcriptional regulator FK536_RS06835 ENOG4108NFH Sugar hydrolase FK536_RS06840 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FK536_RS06845 ENOG4105EAA nucleoside FK536_RS06855 ENOG4105CN8 Transcriptional regulator FK536_RS06890 ENOG4105GXM Putative transcription regulator (DUF1323) FK536_RS06895 ENOG4105HZG regulatoR FK536_RS06910 ENOG4108KMM Diguanylate cyclase FK536_RS06915 ENOG4105D9N nucleoside FK536_RS06925 ENOG4109076 Conserved Protein FK536_RS06930 ENOG4105VCT ion-transport protein YfeO FK536_RS06940 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FK536_RS06945 ENOG410863U PTS System FK536_RS06950 ENOG4105DC7 peptidase M24 FK536_RS06955 ENOG4105CN9 Peptidase m42 family protein FK536_RS06960 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FK536_RS06965 ENOG4108CIP transcriptional regulator FK536_RS06970 ENOG4105DY9 regulatoR FK536_RS06975 ENOG4108HRK Histidine kinase FK536_RS06980 ENOG4105CHM Aminotransferase FK536_RS06990 ENOG4105D1S lipid A biosynthesis FK536_RS06995 ENOG4105W9M Membrane FK536_RS07005 ENOG4108V08 YfdX protein FK536_RS07015 ENOG4105CFN oxalyl-CoA decarboxylase FK536_RS07020 ENOG4108N2Y auxin Efflux FK536_RS07025 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FK536_RS07030 ENOG4105BZU Histidine kinase FK536_RS07035 ENOG4108WQH regulatoR FK536_RS07040 ENOG4105CW7 secretion protein, HlyD family FK536_RS07045 ENOG4105C0R drug resistance transporter emrb qaca subfamily FK536_RS07055 ENOG4105C6Z Gluconate FK536_RS07065 ENOG41077V0 CPS-53 (KpLE1) prophage FK536_RS07110 ENOG4108T86 baseplate J family protein FK536_RS07115 ENOG4105Y0G tail protein FK536_RS07145 ENOG4105DFP Integrase FK536_RS07155 ENOG4105S64 Formate nitrite transporter FK536_RS07160 ENOG410903C (LipO)protein FK536_RS07170 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FK536_RS07175 ENOG4105KZW UPF0381 protein FK536_RS07180 ENOG4105CHU acetyl-coa acetyltransferase FK536_RS07185 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FK536_RS07190 ENOG4108BY2 phosphohistidine phosphatase FK536_RS07200 ENOG4106PG1 outer membrane usher protein FK536_RS07205 ENOG4108FZ9 Chaperone FK536_RS07210 ENOG4105NEV Fimbrial FK536_RS07215 ENOG4105UGQ Fimbrial FK536_RS07220 ENOG4105US4 fimbrial-like protein yfcP FK536_RS07235 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FK536_RS07245 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) FK536_RS07250 ENOG4105EJ9 Membrane FK536_RS07255 ENOG4108BPE -transporting atpase FK536_RS07260 ENOG4105MH2 YfcL protein FK536_RS07265 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FK536_RS07270 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FK536_RS07275 ENOG4105F9N Major Facilitator Superfamily FK536_RS07280 ENOG4106WZ1 flagella biosynthesis regulator FK536_RS07285 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) FK536_RS07290 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FK536_RS07300 ENOG4105DQR SNARE associated Golgi FK536_RS07310 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FK536_RS07315 ENOG4108S3P Sporulation domain protein FK536_RS07320 ENOG4105E96 Colicin v production protein FK536_RS07325 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FK536_RS07330 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FK536_RS07335 ENOG4105E89 ABC transporter FK536_RS07340 ENOG4105E89 ABC transporter FK536_RS07345 ENOG4105DSP amino acid AbC transporter FK536_RS07350 ENOG4106YG3 ABC transporter FK536_RS07355 ENOG4108JEH abc transporter atp-binding protein FK536_RS07360 ENOG4105DNE Transposase FK536_RS07365 ENOG4105ECP epimerase FK536_RS07370 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase FK536_RS07375 ENOG4105CYM Glutathione S-transferase FK536_RS07380 ENOG4108SHQ Glutathione S-transferase FK536_RS07385 ENOG4108RE9 Phosphodiesterase FK536_RS07390 ENOG4105PTV Nudix Hydrolase FK536_RS07395 ENOG4105CSX c4-dicarboxylate anaerobic carrier FK536_RS07400 ENOG4105C6K Malic enzyme FK536_RS07405 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FK536_RS07415 ENOG4105XWI UPF0304 protein FK536_RS07420 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FK536_RS07425 ENOG4107QWE )-transporter FK536_RS07430 ENOG4105DK2 UPF0207 protein FK536_RS07435 ENOG4105CHM Aminotransferase FK536_RS07440 ENOG4107NQ8 LysR family Transcriptional regulator FK536_RS07460 ENOG4105GKE subunit e FK536_RS07465 ENOG4107QIZ NADH dehydrogenase FK536_RS07470 ENOG4107R0R NADH dehydrogenase subunit g FK536_RS07485 ENOG4107UFS subunit j FK536_RS07495 ENOG4105D65 subunit l FK536_RS07500 ENOG4105C8S subunit m FK536_RS07510 ENOG4105GDX Domain of unknown function (DUF1877) FK536_RS07530 ENOG4107YB6 acetyltransferase, (GNAT) family FK536_RS07535 ENOG4105TNS Conserved Protein FK536_RS07540 ENOG4105E4F Isochorismate synthase FK536_RS07550 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FK536_RS07555 ENOG4108IPT Naphthoate synthase FK536_RS07560 ENOG4105DNI Converts SHCHC to OSB (By similarity) FK536_RS07565 ENOG4105CEY Amp-dependent synthetase and ligase FK536_RS07570 ENOG4106GZG polymyxin resistance protein B FK536_RS07575 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FK536_RS07585 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FK536_RS07595 ENOG4105C3I Nad-dependent epimerase dehydratase FK536_RS07610 ENOG4108WMR Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity) FK536_RS07615 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) FK536_RS07620 ENOG4108UII YfaZ family FK536_RS07625 ENOG4108EWA cinA-like protein FK536_RS07630 ENOG4107258 Transcriptional regulator FK536_RS07635 ENOG4105CXK mandelate racemase muconate lactonizing FK536_RS07640 ENOG4105CSP Major Facilitator Superfamily FK536_RS07655 ENOG4105DNE Transposase FK536_RS07660 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FK536_RS07665 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B FK536_RS07670 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A FK536_RS07675 ENOG4105CXY transporter FK536_RS07680 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FK536_RS07690 ENOG4105FQR PH-inducible protein involved in stress response FK536_RS07695 ENOG4105XPH Ferredoxin FK536_RS07700 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FK536_RS07705 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FK536_RS07710 ENOG4107GHC outer membrane autotransporter FK536_RS07720 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FK536_RS07725 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) FK536_RS07730 ENOG4108QJJ Protein of unknown function (DUF1175) FK536_RS07740 ENOG41081SK signal peptide protein FK536_RS07745 ENOG4105EDV vault protein FK536_RS07750 ENOG4105CHU acetyl-coa acetyltransferase FK536_RS07755 ENOG4105CRW Short chain fatty acid transporter FK536_RS07760 ENOG4107QNJ CoA-transferase subunit B FK536_RS07765 ENOG4107QP7 CoA-transferase subunit A FK536_RS07770 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FK536_RS07775 ENOG4105BZU Histidine kinase FK536_RS07780 ENOG4105BZU Histidine kinase FK536_RS07785 ENOG41068CG regulatoR FK536_RS07790 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC FK536_RS07795 ENOG4105FCK Membrane FK536_RS07800 ENOG4105CJ2 (LipO)protein FK536_RS07805 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FK536_RS07810 ENOG4105CF1 Alkylated DNA repair protein FK536_RS07815 ENOG4105IBP Cyclic peptide transporter FK536_RS07820 ENOG4105DWT malate dehydrogenase (quinone) FK536_RS07835 ENOG4108ZNS ferredoxin-type protein NapF FK536_RS07840 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase FK536_RS07845 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FK536_RS07850 ENOG4108BGM Quinol dehydrogenase periplasmic component FK536_RS07855 ENOG4105GXZ Ferredoxin-type protein NapH FK536_RS07860 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) FK536_RS07865 ENOG4105CUW cytochrome C-TYPE protein FK536_RS07870 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FK536_RS07875 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FK536_RS07880 ENOG41060IM Heme exporter protein FK536_RS07885 ENOG4105X3C heme exporter protein FK536_RS07895 ENOG4105DA4 cytochrome c-type biogenesis protein FK536_RS07900 ENOG4107QX9 Thiol disulfide interChange protein FK536_RS07905 ENOG4105KWW Biogenesis protein FK536_RS07910 ENOG4105WH1 Two component transcriptional regulator luxr family FK536_RS07915 ENOG4108MGN ATP-binding component of a transport system FK536_RS07925 ENOG4105E68 Sulfatase FK536_RS07945 ENOG4105CFI type iii restriction protein res subunit FK536_RS07950 ENOG4105I08 Pseudouridine synthase FK536_RS07955 ENOG4105C2C drug resistance transporter, Bcr CflA FK536_RS07960 ENOG4105HG6 FK536_RS07965 ENOG4108JQ5 ABC transporter FK536_RS07970 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FK536_RS07975 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FK536_RS07980 ENOG4105E43 Extracellular solute-binding protein, family 5 FK536_RS07985 ENOG4105CXC rtn protein FK536_RS07990 ENOG4107TT5 NLP P60 protein FK536_RS07995 ENOG41076MN Phosphoesterase, PA-phosphatase related FK536_RS08000 ENOG4105CKI cobalamin synthesis protein FK536_RS08005 ENOG4105DEI Mannitol dehydrogenase FK536_RS08015 ENOG4105KRS Proteinase inhibitor FK536_RS08020 ENOG4105S8Q sugar efflux transporter FK536_RS08025 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FK536_RS08030 ENOG4105DE4 1-phosphofructokinase FK536_RS08035 ENOG4105DM4 PTS System FK536_RS08040 ENOG4105DD7 kinase (PfkB family FK536_RS08045 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FK536_RS08050 ENOG4105D9N nucleoside FK536_RS08055 ENOG4108Y4K DNA-binding transcriptional activator FK536_RS08065 ENOG4105D9N nucleoside FK536_RS08070 ENOG4105DD7 kinase (PfkB family FK536_RS08075 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FK536_RS08080 ENOG4105HMI Membrane FK536_RS08085 ENOG4105DUM transcriptional regulator, lysR family FK536_RS08090 ENOG4108IQI permease FK536_RS08095 ENOG4105D05 Receptor FK536_RS08110 ENOG4105DHF Membrane FK536_RS08115 ENOG41060NJ transcriptional regulator FK536_RS08120 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator FK536_RS08125 ENOG4105C2J ABC transporter FK536_RS08130 ENOG4108HWV )-transporter FK536_RS08135 ENOG4107SJI Dehydrogenase FK536_RS08140 ENOG4105BZ8 glutamate synthase FK536_RS08145 ENOG4105Y9N Membrane FK536_RS08150 ENOG4107GZ4 SanA protein FK536_RS08160 ENOG41067MG lrgb family FK536_RS08170 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FK536_RS08180 ENOG4105ETP RND efflux system, outer membrane lipoprotein FK536_RS08185 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FK536_RS08190 ENOG4105KHU inner membrane protein YohD FK536_RS08195 ENOG41069YE inner membrane protein yohC FK536_RS08200 ENOG41061WM D-Alanyl-D-Alanine FK536_RS08205 ENOG4105CXG d-lactate dehydrogenase FK536_RS08210 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FK536_RS08215 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FK536_RS08220 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component FK536_RS08225 ENOG4108IJ8 ABC transporter FK536_RS08230 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component FK536_RS08240 ENOG4108XDN Transcriptional regulator FK536_RS08245 ENOG4108HRK Histidine kinase FK536_RS08250 ENOG4108NEV two component transcriptional regulator, LytTR family FK536_RS08255 ENOG4108W15 Protein of unknown function (DUF1456) FK536_RS08260 ENOG4108YCW (LipO)protein FK536_RS08265 ENOG410903U zinc ion binding FK536_RS08270 ENOG4105DEG Vwa containing coxe family protein FK536_RS08275 ENOG4105RD5 FK536_RS08280 ENOG4105KKX ATPase associated with various cellular activities aaa_5 FK536_RS08295 ENOG4108KDT Molybdate metabolism regulator FK536_RS08305 ENOG4105D1F ATP-binding protein FK536_RS08310 ENOG41067AK Protein of unknown function (DUF2574) FK536_RS08315 ENOG41063W2 Fimbrial protein FK536_RS08320 ENOG4108MQF Chaperone FK536_RS08325 ENOG4105CW0 outer membrane usher protein FK536_RS08330 ENOG410662B Type-1 fimbrial protein FK536_RS08335 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly FK536_RS08355 ENOG4105DWF phosphomethylpyrimidine kinase FK536_RS08360 ENOG4108UQ1 hydrolase, family 25 FK536_RS08365 ENOG4105FDP GntR family transcriptional regulator FK536_RS08370 ENOG4108TFM Kinase, PfkB family FK536_RS08375 ENOG4108KD5 ADP-ribosylation crystallin J1 FK536_RS08380 ENOG4105EAA nucleoside FK536_RS08385 ENOG4105EIE fructose-bisphosphate aldolase FK536_RS08405 ENOG41090UW PTS System FK536_RS08410 ENOG4105DT3 PTS system, galactitol-specific IIc component FK536_RS08415 ENOG4107WTH Galactitol-1-phosphate dehydrogenase FK536_RS08430 ENOG41076Z6 Uncharacterized protein yegR FK536_RS08435 ENOG4105CFP Peptidase U32 FK536_RS08445 ENOG4105X54 addiction module antidote protein FK536_RS08450 ENOG4105KWI UPF0339 protein FK536_RS08455 ENOG4105E3W Two component transcriptional regulator (Winged helix family FK536_RS08460 ENOG4105EB3 Histidine kinase FK536_RS08500 ENOG4108M24 von Willebrand factor, type A FK536_RS08505 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase FK536_RS08510 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding FK536_RS08515 ENOG4105R8A Heat shock protein FK536_RS08520 ENOG4105D03 DNA-3-methyladenine glycosylase II FK536_RS08525 ENOG4105BZU Histidine kinase FK536_RS08530 ENOG4105DBI uridine monophosphokinase FK536_RS08540 ENOG4108GAE asmA family FK536_RS08545 ENOG4105EE5 Membrane protein terC FK536_RS08550 ENOG4105DAY polysaccharide export protein FK536_RS08555 ENOG4105KJF protein tyrosine phosphatase FK536_RS08560 ENOG4105D75 Capsular exopolysaccharide family FK536_RS08565 ENOG41090RK glycosyl transferase FK536_RS08570 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB FK536_RS08575 ENOG4107RXY Glycosyl transferase FK536_RS08580 ENOG4108NYJ Colanic acid FK536_RS08585 ENOG4105ECJ Glycosyl Transferase FK536_RS08590 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF FK536_RS08595 ENOG4105C0K Gdp-mannose 4,6-dehydratase FK536_RS08600 ENOG4105C30 Nad-dependent epimerase dehydratase FK536_RS08605 ENOG4105FGF GDP-mannose mannosyl hydrolase FK536_RS08610 ENOG4106CD9 glycosyl transferase group 1 FK536_RS08615 ENOG4105CJT Mannose-1-phosphate guanylyltransferase FK536_RS08620 ENOG4107QKV phosphomannomutase FK536_RS08625 ENOG4105D3Q Sugar transferase FK536_RS08630 ENOG4105PSV Polysaccharide Biosynthesis Protein FK536_RS08635 ENOG4105C74 pyruvyl transferase FK536_RS08640 ENOG4107T8Q Glycosyl transferase (Group 1 FK536_RS08645 ENOG4105G1A colanic acid biosynthesis protein FK536_RS08650 ENOG4105DMT epimerase dehydratase FK536_RS08655 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FK536_RS08660 ENOG4105C1B dTDP-glucose 4-6-dehydratase FK536_RS08665 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FK536_RS08705 ENOG4108RYC glycosyltransferase FK536_RS08710 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FK536_RS08715 ENOG4105C6Y Udp-glucose 6-dehydrogenase FK536_RS08720 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) FK536_RS08725 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FK536_RS08740 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FK536_RS08745 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FK536_RS08750 ENOG4105CIH Imidazole acetol-phosphate transaminase FK536_RS08755 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FK536_RS08770 ENOG4107SRH Nad-dependent epimerase dehydratase FK536_RS08775 ENOG4105EQ1 Transcriptional regulator FK536_RS08785 ENOG4105CUB amino acid FK536_RS08790 ENOG4105CUC YeeE YedE family protein FK536_RS08800 ENOG4105CJB Exodeoxyribonuclease I FK536_RS08805 ENOG4105DZ1 carboxypeptidase FK536_RS08815 ENOG4105DR8 Membrane FK536_RS08850 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles FK536_RS08860 ENOG4108YGG dna repair protein FK536_RS08865 ENOG4105MFG Antirestriction protein FK536_RS08870 ENOG4106H6R UPF0380 protein FK536_RS08890 ENOG4108YIV FK536_RS08915 ENOG41080QX K07048 phosphotriesterase-related protein FK536_RS08930 ENOG4108RVA ribokinase FK536_RS08950 ENOG4108YZT Adenosylcobinamide kinase FK536_RS08965 ENOG4108PXI ErfK YbiS YcfS YnhG FK536_RS08975 ENOG4106P55 Transcriptional regulator FK536_RS08980 ENOG4107R11 Transcriptional regulator FK536_RS08990 ENOG4105UQX Mate efflux family protein FK536_RS09000 ENOG4105CDY transcriptional regulatory protein FK536_RS09005 ENOG4105FYV Amp nucleosidase FK536_RS09010 ENOG4105CSH Transporter FK536_RS09045 ENOG4108VKM cytochrome b561 FK536_RS09050 ENOG4108MEK Metal-binding protein YodA FK536_RS09060 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) FK536_RS09065 ENOG4105VT2 5-hydroxyisourate hydrolase FK536_RS09070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FK536_RS09075 ENOG4107ZY3 Histidine kinase FK536_RS09085 ENOG4105ZIT Porin Gram-negative type FK536_RS09095 ENOG4105ZIT Porin Gram-negative type FK536_RS09100 ENOG4105Y0K Inner membrane protein YedR FK536_RS09105 ENOG4105EST Metal Dependent Phosphohydrolase FK536_RS09110 ENOG4105DVF Cytosine-specific methyltransferase FK536_RS09115 ENOG41090BB DNA mismatch endonuclease (vsr) FK536_RS09120 ENOG4105FDR Membrane FK536_RS09125 ENOG4105CKW Inner membrane protein yedI FK536_RS09130 ENOG4105VNZ cytoplasmic protein FK536_RS09145 ENOG4105YX3 cellular response to acidity FK536_RS09155 ENOG4107TKS colanic acid capsular biosynthesis activation protein A FK536_RS09160 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FK536_RS09170 ENOG4105CN7 Flagellar biosynthetic protein FliP FK536_RS09175 ENOG4105K0P flagellar biosynthesis protein FK536_RS09180 ENOG4105DD5 Flagellar motor switch protein FK536_RS09185 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FK536_RS09190 ENOG4107ZI8 flagellar basal body-associated protein flil FK536_RS09195 ENOG4105WF4 Flagellar hook-length control protein FK536_RS09200 ENOG4105GSA Flagellar export protein flij FK536_RS09205 ENOG4108JIR Flagellum-specific ATP synthase FK536_RS09210 ENOG41090PJ Flagellar assembly protein FK536_RS09215 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FK536_RS09220 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FK536_RS09225 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FK536_RS09230 ENOG4108RAV Conserved protein FK536_RS09240 ENOG41066VF YeeE YedE family protein FK536_RS09245 ENOG4108W9D (LipO)protein FK536_RS09250 ENOG4105E5K Alpha-amylase FK536_RS09260 ENOG4105MQ3 flagellar protein FliS FK536_RS09265 ENOG4105DTS flagellar hook-associated FK536_RS09270 ENOG4105I03 Flagellin FK536_RS09275 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FK536_RS09280 ENOG4108M9K flagella biosynthesis protein FliZ FK536_RS09285 ENOG4105EAB amino acid AbC transporter FK536_RS09290 ENOG4105K6H D-cysteine desulfhydrase FK536_RS09295 ENOG4105E5Q amino acid AbC transporter FK536_RS09300 ENOG4105CDA abc transporter atp-binding protein FK536_RS09305 ENOG4105VJY transcriptional regulator FK536_RS09310 ENOG4105XVG cytoplasmic protein FK536_RS09320 ENOG4105WH1 Two component transcriptional regulator luxr family FK536_RS09395 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FK536_RS09400 ENOG4105DIJ Phosphoethanolamine transferase FK536_RS09420 ENOG4106RHG Yeca family FK536_RS09425 ENOG4105E0U tyrosine-specific transport protein FK536_RS09430 ENOG4105VVZ metal-binding protein FK536_RS09435 ENOG41090A1 ferritin FK536_RS09440 ENOG4105P23 (LipO)protein FK536_RS09450 ENOG4105N4N Protein of unknown function (DUF2766) FK536_RS09455 ENOG4108UEC Ferritin-like protein FK536_RS09460 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FK536_RS09465 ENOG4105C2J ABC transporter FK536_RS09470 ENOG4105CNN ABC, transporter FK536_RS09475 ENOG4108K4C ec 3.1.3.12 FK536_RS09485 ENOG4108VA4 Universal stress protein FK536_RS09495 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region FK536_RS09500 ENOG4107RD7 Flagellar Motor Protein, MotA FK536_RS09505 ENOG4105ER2 Ompa motb domain protein FK536_RS09510 ENOG4105CBS Chea signal transduction histidine kinase FK536_RS09515 ENOG4108V3W Chemotaxis protein, CheW FK536_RS09520 ENOG4105C8Q Methyl-accepting chemotaxis FK536_RS09525 ENOG4105C8Q Methyl-accepting chemotaxis FK536_RS09530 ENOG4105BZU Histidine kinase FK536_RS09535 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FK536_RS09540 ENOG4108VYJ response regulator receiver protein FK536_RS09545 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FK536_RS09550 ENOG4105D00 flagellar biosynthetic protein flhB FK536_RS09555 ENOG4105D7B Flagellar biosynthesis protein flha FK536_RS09560 ENOG4105W13 flagellar protein FK536_RS09570 ENOG4105C75 arginyL-tRNA synthetase FK536_RS09575 ENOG4106ZCM YecM protein FK536_RS09585 ENOG4105CUW cytochrome C-TYPE protein FK536_RS09590 ENOG4107QY8 reductase FK536_RS09600 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) FK536_RS09605 ENOG4105WJG Glutathione FK536_RS09610 ENOG41081XQ Conserved Protein FK536_RS09615 ENOG4105D3W isochorismatase FK536_RS09625 ENOG4108TIT dATP pyrophosphohydrolase FK536_RS09630 ENOG4105CDY transcriptional regulatory protein FK536_RS09640 ENOG4107S01 Repressor protein MetJ FK536_RS09660 ENOG4105FAV ABC, transporter FK536_RS09670 ENOG4105NXV High-affinity zinc uptake system protein FK536_RS09675 ENOG4105DR5 peptidase FK536_RS09680 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FK536_RS09685 ENOG4105CA9 Pyruvate kinase FK536_RS09690 ENOG4106KNT transcriptional regulator FK536_RS09695 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FK536_RS09700 ENOG4105C01 Dihydroxy-acid dehydratase FK536_RS09705 ENOG4108UHU Aldolase FK536_RS09710 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR FK536_RS09715 ENOG4105X2V dna damage-inducible protein FK536_RS09725 ENOG4108Q2J Inner membrane protein YebE FK536_RS09730 ENOG4105CUG Oligopeptidase b FK536_RS09735 ENOG4105UMD exodeoxyribonuclease X FK536_RS09740 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FK536_RS09745 ENOG4105MPK DNA polymerase III subunit theta FK536_RS09750 ENOG4105FXM Copper resistance protein FK536_RS09755 ENOG4108PNC copper resistance FK536_RS09760 ENOG4105NKT exported protein FK536_RS09765 ENOG4108R1E Serine threonine protein phosphatase 1 FK536_RS09770 ENOG4105UVW uncharacterized protein yebW FK536_RS09775 ENOG4105WT8 Protein of unknown function (DUF1480) FK536_RS09785 ENOG4105DY2 Paraquat-inducible protein b FK536_RS09790 ENOG4105H2K paraquat-inducible protein a FK536_RS09795 ENOG4108ZGC gaf domain protein FK536_RS09805 ENOG4105CN1 protease FK536_RS09815 ENOG4105C0R drug resistance transporter emrb qaca subfamily FK536_RS09820 ENOG4105J4Q Transcriptional regulator FK536_RS09825 ENOG4105TIK FK536_RS09835 ENOG4105Q3Y exported protein FK536_RS09850 ENOG4105DHI Methyltransferase FK536_RS09865 ENOG4105F3R pts system mannose fructose sorbose family iid FK536_RS09870 ENOG4105ETZ PTS System FK536_RS09875 ENOG4105DAS pts system FK536_RS09880 ENOG4105EE5 Membrane protein terC FK536_RS09885 ENOG4107XTP (EAL) domain protein FK536_RS09890 ENOG4105EJQ L-serine dehydratase FK536_RS09895 ENOG4105P8F nudix hydrolase FK536_RS09900 ENOG4105CRQ synthase (Component I) FK536_RS09910 ENOG4105V2F Uncharacterized protein yoac FK536_RS09915 ENOG4105M4H endoribonuclease L-psp FK536_RS09920 ENOG4105DVT helicase FK536_RS09925 ENOG41072GX Peptidase M22 Glycoprotease FK536_RS09930 ENOG4105Y4Z Outer Membrane Lipoprotein FK536_RS09935 ENOG4105CEY Amp-dependent synthetase and ligase FK536_RS09940 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FK536_RS09945 ENOG4105E3J oxidoreductase FK536_RS09950 ENOG4105DVW rieske (2Fe-2S) FK536_RS09960 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FK536_RS09965 ENOG4105EJC lysr family transcriptional regulator FK536_RS09975 ENOG4108YS1 cytoplasmic protein FK536_RS09980 ENOG4105YP6 Domain of unknown function (DUF1869) FK536_RS09985 ENOG4105Y3U Transglycosylase-associated protein FK536_RS09995 ENOG4106G4W FK536_RS10000 ENOG410620I Diguanylate cyclase FK536_RS10005 ENOG4105UCG Domain of unknown function (DUF333) FK536_RS10010 ENOG4105K78 MarR family Transcriptional regulator FK536_RS10015 ENOG4105DJ2 Major Facilitator Superfamily FK536_RS10020 ENOG4105R1U AraC Family Transcriptional Regulator FK536_RS10035 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FK536_RS10040 ENOG4108KHP Diguanylate cyclase FK536_RS10045 ENOG4106KTS Inner membrane protein yeaI FK536_RS10050 ENOG4106AKX UPF0229 protein FK536_RS10055 ENOG4105CYN Serine protein kinase FK536_RS10060 ENOG4105GNX MltA-interacting MipA family protein FK536_RS10065 ENOG4105CV8 reductase FK536_RS10070 ENOG4105DSB aldose 1-epimerase FK536_RS10075 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FK536_RS10085 ENOG4105VUT cytoplasmic protein FK536_RS10095 ENOG4107TE1 transport protein FK536_RS10100 ENOG4105CPQ Dehydrogenase FK536_RS10105 ENOG4105D2N Aldolase FK536_RS10110 ENOG4107UH8 sugar kinase FK536_RS10115 ENOG4105CPC Aldo Keto reductase FK536_RS10120 ENOG4105E98 transcriptional regulator DeoR family FK536_RS10135 ENOG4108RWI nicotinamidase FK536_RS10140 ENOG4105HDK L-asparaginase FK536_RS10145 ENOG4105D07 Signal peptide peptidase, SppA FK536_RS10150 ENOG41069NU Nitroreductase FK536_RS10160 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FK536_RS10165 ENOG41065FB inner membrane protein ynji FK536_RS10170 ENOG4105D82 Glutamate dehydrogenase FK536_RS10175 ENOG4105MTM Protein of unknown function (DUF1496) FK536_RS10180 ENOG4105M6F mutator MutT protein FK536_RS10185 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FK536_RS10190 ENOG4107RM6 sulfurtransferase FK536_RS10195 ENOG4108VGW abc transporter atp-binding protein FK536_RS10200 ENOG4105CXZ ABC transporter, permease FK536_RS10205 ENOG4105VNH ABC transporter solute-binding protein FK536_RS10210 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FK536_RS10215 ENOG4108N5C SNARE associated Golgi protein-related protein FK536_RS10220 ENOG4108KCW iron-sulfur cluster binding FK536_RS10225 ENOG4108RSN SNARE associated Golgi FK536_RS10230 ENOG4105CGK Exodeoxyribonuclease III FK536_RS10250 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) FK536_RS10265 ENOG4108SPG Periplasmic Protein FK536_RS10275 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) FK536_RS10285 ENOG4105KKI DNA-binding transcriptional activator OsmE FK536_RS10290 ENOG4105VZJ PTS System FK536_RS10295 ENOG4105CK1 PTS System FK536_RS10300 ENOG4105VCP PTS System FK536_RS10305 ENOG4105EZV Transcriptional regulator FK536_RS10310 ENOG4105F8D glycoside hydrolase family 4 FK536_RS10315 ENOG410901P UPF0249 protein FK536_RS10320 ENOG4105CH6 catalase FK536_RS10345 ENOG4108ETY sodium dicarboxylate symporter FK536_RS10350 ENOG4107K5X Membrane-bound metal-dependent hydrolase FK536_RS10355 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FK536_RS10360 ENOG4107PN8 YfeABCD locus regulator FK536_RS10370 ENOG4105P10 Uncharacterized protein ydiZ FK536_RS10375 ENOG4105DE4 1-phosphofructokinase FK536_RS10380 ENOG4108NE3 Salt-induced outer membrane protein FK536_RS10400 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FK536_RS10405 ENOG41082NX 50s ribosomal protein l35 FK536_RS10425 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FK536_RS10440 ENOG4108V06 Glutathione peroxidase FK536_RS10450 ENOG4108QBX (LipO)protein FK536_RS10455 ENOG4108TC0 Diguanylate phosphodiesterase FK536_RS10470 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FK536_RS10480 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FK536_RS10485 ENOG4105CEY Amp-dependent synthetase and ligase FK536_RS10490 ENOG41090P5 ferredoxin-like protein FK536_RS10495 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FK536_RS10500 ENOG4105C10 Electron transfer flavoprotein FK536_RS10505 ENOG4105CV7 Electron transfer flavoprotein FK536_RS10510 ENOG4105W4W Transcriptional regulator FK536_RS10515 ENOG4105C1G acyl-Coa dehydrogenase FK536_RS10520 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) FK536_RS10535 ENOG4105EMV Major Facilitator FK536_RS10540 ENOG4105EMV Major Facilitator FK536_RS10545 ENOG4105SUA Ydil protein FK536_RS10555 ENOG4105IPI Membrane FK536_RS10560 ENOG4105CQB FAD linked oxidase domain protein FK536_RS10565 ENOG4105KA0 thioesterase Superfamily protein FK536_RS10570 ENOG410671Z uncharacterized protein ydiH FK536_RS10575 ENOG4108Z4V iron-sulfur cluster assembly FK536_RS10580 ENOG4105DIW FeS assembly protein SUFB FK536_RS10585 ENOG4105C3K feS assembly ATPase SufC FK536_RS10590 ENOG4105JRK feS assembly protein SufD FK536_RS10595 ENOG4105C9B Cysteine desulfurase FK536_RS10605 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FK536_RS10610 ENOG4105KMX major outer membrane lipoprotein FK536_RS10615 ENOG4105CA9 Pyruvate kinase FK536_RS10620 ENOG4105RFR Protein of unknown function (DUF2767) FK536_RS10625 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein FK536_RS10630 ENOG4105WE2 aldehyde ferredoxin oxidoreductase FK536_RS10635 ENOG4105JVW FK536_RS10640 ENOG4108393 oxidoreductase Fe-S subunit FK536_RS10645 ENOG4108NWD Cytochrome FK536_RS10650 ENOG4108Y7C Conserved Protein FK536_RS10655 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain FK536_RS10660 ENOG4105N0V mono-oxygenase ydhR FK536_RS10680 ENOG4107QI1 Mate efflux family protein FK536_RS10685 ENOG4108R6K riboflavin synthase, subunit alpha FK536_RS10690 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FK536_RS10695 ENOG4105CZQ inner membrane transport protein YdhC FK536_RS10700 ENOG4105F52 Transcriptional regulator FK536_RS10715 ENOG4105F27 Major Facilitator FK536_RS10720 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FK536_RS10725 ENOG4105K4H Nlp p60 protein FK536_RS10735 ENOG4105M2J Glutaredoxin FK536_RS10740 ENOG4107QRT dEAD DEAH box helicase FK536_RS10745 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FK536_RS10750 ENOG4108UYE Lactoylglutathione lyase FK536_RS10755 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FK536_RS10760 ENOG4108WUH Transcriptional regulator, TetR family FK536_RS10765 ENOG4105XZD Fe-S protein FK536_RS10770 ENOG4107RGM aldo keto reductase FK536_RS10775 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FK536_RS10780 ENOG4105DSW Fusaric acid resistance protein FK536_RS10785 ENOG4105Y49 secretion protein, HlyD family FK536_RS10800 ENOG4108XTF Outer Membrane Lipoprotein FK536_RS10810 ENOG410642K Lysozyme inhibitor FK536_RS10825 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FK536_RS10830 ENOG4108K3A Glutathione S-transferase FK536_RS10835 ENOG4105DUX Transporter FK536_RS10840 ENOG4105CSM endonuclease III FK536_RS10850 ENOG4108UQQ Electron transport complex FK536_RS10875 ENOG4105M9B inner membrane protein ydgK FK536_RS10880 ENOG4105QZ5 OriC-binding nucleoid-associated protein FK536_RS10885 ENOG4106C6R beta-lactam resistance protein FK536_RS10890 ENOG4105D9R oxidoreductase FK536_RS10900 ENOG4105C87 Aminotransferase class I and II FK536_RS10905 ENOG4105CI1 PTS System FK536_RS10910 ENOG4107P2S Transcriptional regulator FK536_RS10915 ENOG4107ZQV short-chain dehydrogenase reductase FK536_RS10920 ENOG4105XEA Tetr family transcriptional regulator FK536_RS10925 ENOG4105CNT hydrolase family 2 FK536_RS10930 ENOG4105CT4 transporter FK536_RS10935 ENOG4108QNI outer membrane porin protein FK536_RS10940 ENOG4106J39 exported protein FK536_RS10945 ENOG4105EIP mannose-6-phosphate isomerase FK536_RS10950 ENOG4107GFK fumarate FK536_RS10955 ENOG4105C9Q fumarate hydratase class II FK536_RS10965 ENOG4105JJR Histidine kinase FK536_RS10970 ENOG4107EXC regulatoR FK536_RS10975 ENOG4105RA2 Membrane FK536_RS10985 ENOG4105D5Q Arginine ornithine antiporter FK536_RS10990 ENOG4105C5D exported protein FK536_RS10995 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FK536_RS11000 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FK536_RS11005 ENOG4105DSF transport protein FK536_RS11020 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap FK536_RS11035 ENOG4105D94 Major Facilitator Superfamily FK536_RS11040 ENOG4106NZI LysR family Transcriptional regulator FK536_RS11045 ENOG4105DAG ROK family FK536_RS11050 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FK536_RS11060 ENOG4108NEM leader-binding protein dmsD FK536_RS11065 ENOG4107KGK dmso reductase anchor subunit FK536_RS11070 ENOG4105QAX Iron-sulfur FK536_RS11075 ENOG4105C3J Cysteine desulfurase FK536_RS11080 ENOG4107QY8 reductase FK536_RS11085 ENOG4105KBG Protein of unknown function (DUF1161) FK536_RS11090 ENOG4105D69 UPF0257 lipoprotein ynfC FK536_RS11095 ENOG4108MK9 spermidine N(1)-acetyltransferase FK536_RS11110 ENOG4105CXK mandelate racemase muconate lactonizing FK536_RS11115 ENOG4105CPQ Dehydrogenase FK536_RS11125 ENOG4107R08 Integrase FK536_RS11140 ENOG4106G8A Qin prophage FK536_RS11160 ENOG4105DEI Mannitol dehydrogenase FK536_RS11165 ENOG41061EV selenium-binding protein YdfZ FK536_RS11170 ENOG4107XBN GntR Family Transcriptional Regulator FK536_RS11175 ENOG4105EMU Dehydrogenase FK536_RS11180 ENOG4105DGW oligopeptidase A FK536_RS11185 ENOG4108WTK competence damage-inducible protein FK536_RS11195 ENOG4108YDI single-species biofilm formation on inanimate substrate FK536_RS11200 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria FK536_RS11210 ENOG4105E5W Transporter FK536_RS11215 ENOG4108594 Permease of the drug metabolite transporter FK536_RS11220 ENOG4106DNR multiple antibiotic resistance protein FK536_RS11225 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF FK536_RS11230 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FK536_RS11250 ENOG4105EGI Transcriptional regulator FK536_RS11255 ENOG4105C26 Dehydrogenase FK536_RS11260 ENOG4105CSV Glutaminase FK536_RS11265 ENOG4105M0C cytoplasmic protein FK536_RS11270 ENOG4105BZU Histidine kinase FK536_RS11280 ENOG4105FFC UPF0187 protein FK536_RS11285 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) FK536_RS11290 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound FK536_RS11300 ENOG4105D4B ABC, transporter FK536_RS11310 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FK536_RS11315 ENOG4105C2J ABC transporter FK536_RS11335 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein FK536_RS11340 ENOG4105CAF HipA N-terminal domain protein FK536_RS11395 ENOG4108WDE Fimbrial protein FK536_RS11400 ENOG4106318 fimbrial-like protein YdeR FK536_RS11405 ENOG4106PIH fimbrial-like protein ydeQ FK536_RS11410 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FK536_RS11425 ENOG4105ENH Sulfatase FK536_RS11430 ENOG4105C4X radical SAM domain protein FK536_RS11440 ENOG4105CQ0 ABC transporter FK536_RS11445 ENOG4105PE1 Receptor FK536_RS11450 ENOG4107RAN Peptidase, M16 FK536_RS11455 ENOG4105CVK Glutamate decarboxylase FK536_RS11460 ENOG4105E5D amino acid FK536_RS11465 ENOG4105F32 YngK protein FK536_RS11470 ENOG4105BZU Histidine kinase FK536_RS11475 ENOG4105BZU Histidine kinase FK536_RS11480 ENOG4108UQS dipeptidase FK536_RS11485 ENOG4105DEF Extracellular solute-binding protein, family 5 FK536_RS11490 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FK536_RS11495 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FK536_RS11500 ENOG4105C3U ABC transporter FK536_RS11505 ENOG4107H6U ABC transporter FK536_RS11510 ENOG4108Z9K Osmotically inducible protein FK536_RS11515 ENOG4105TPS biofilm-dependent modulation protein FK536_RS11520 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein FK536_RS11530 ENOG4105DQ4 alcohol dehydrogenase FK536_RS11535 ENOG41084S7 Plasmid maintenance system antidote protein FK536_RS11540 ENOG4108MG3 formate dehydrogenase FK536_RS11545 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FK536_RS11555 ENOG4105RPH Inner membrane protein YddG FK536_RS11570 ENOG4107QND Nitrite extrusion protein FK536_RS11575 ENOG4105CRU nitrate reductase, alpha subunit FK536_RS11580 ENOG4108IUE nitrate reductase beta subunit FK536_RS11585 ENOG4108NZN Respiratory nitrate reductase 2 delta chain FK536_RS11590 ENOG4105D0D Nitrate reductase 2, gamma subunit FK536_RS11595 ENOG4105JAB phenazine biosynthesis protein, phzf family FK536_RS11600 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FK536_RS11605 ENOG4108MEJ flavin reductase domain protein FK536_RS11610 ENOG4105KZK Tautomerase pptA FK536_RS11615 ENOG410600T transposase FK536_RS11635 ENOG4105CNA YD repeat protein FK536_RS11645 ENOG4108N27 Glutathione S-transferase FK536_RS11650 ENOG4105C85 amino acid FK536_RS11655 ENOG4108NS2 receptor FK536_RS11660 ENOG4105CHB tonB-dependent Receptor FK536_RS11665 ENOG4108WYP Transcriptional regulator FK536_RS11670 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FK536_RS11675 ENOG4108Z7F N-acetyltransferase FK536_RS11680 ENOG4108T9Y Inner membrane protein ydcZ FK536_RS11685 ENOG4105R71 cytoplasmic protein FK536_RS11690 ENOG410654E Membrane FK536_RS11705 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FK536_RS11710 ENOG4105D81 ABC transporter, permease FK536_RS11715 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FK536_RS11720 ENOG4107TYH extracellular solute-binding protein family 1 FK536_RS11725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FK536_RS11730 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin FK536_RS11740 ENOG4105RR0 Protein of unknown function (DUF2554) FK536_RS11745 ENOG4105CFP Peptidase U32 FK536_RS11750 ENOG4108JCI Transcriptional regulator FK536_RS11755 ENOG4105DKK Benzoate FK536_RS11760 ENOG4105D7V transposase FK536_RS11770 ENOG4108KKZ (LipO)protein FK536_RS11775 ENOG41088CC tellurite resistance protein tehB FK536_RS11780 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein FK536_RS11785 ENOG4107WE3 acetyltransferase YdcK FK536_RS11790 ENOG4108Z9I -acetyltransferase FK536_RS11795 ENOG4105Z2P Protein of unknown function (DUF465) FK536_RS11800 ENOG4105DJ9 glucan biosynthesis protein FK536_RS11805 ENOG4105E32 cytoplasmic protein FK536_RS11810 ENOG4105DDW LysR family Transcriptional regulator FK536_RS11815 ENOG4105C8Q Methyl-accepting chemotaxis FK536_RS11825 ENOG4107NK6 Hok/gef family FK536_RS11830 ENOG4105UPP uncharacterized protein ydcA FK536_RS11835 ENOG4105CPW cytochrome b561 FK536_RS11845 ENOG4105C26 Dehydrogenase FK536_RS11850 ENOG4107DB1 DUF218 domain FK536_RS11860 ENOG4107DB1 DUF218 domain FK536_RS11865 ENOG4105CQ7 ATP-dependent helicase FK536_RS11880 ENOG4105E8V Alpha Beta Hydrolase Fold protein FK536_RS11885 ENOG4108HPI phosphatidate Cytidylyltransferase FK536_RS11890 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase FK536_RS11900 ENOG4107S5I aldo keto reductase FK536_RS11905 ENOG4107EF2 surface-exposed virulence protein FK536_RS11915 ENOG4108Z0R Transferase FK536_RS11920 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FK536_RS11925 ENOG4105DZS Phenylacetate-CoA ligase FK536_RS11930 ENOG4105CHU acetyl-coa acetyltransferase FK536_RS11935 ENOG4108ZJI phenylacetic acid degradation protein FK536_RS11940 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FK536_RS11945 ENOG4108UKI Enoyl-CoA hydratase FK536_RS11950 ENOG4105E39 Enoyl-CoA hydratase FK536_RS11955 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FK536_RS11960 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FK536_RS11965 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FK536_RS11970 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FK536_RS11975 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FK536_RS11980 ENOG4105DXM phenylacetic acid degradation protein FK536_RS11985 ENOG4105F11 amine oxidase FK536_RS11990 ENOG4105C26 Dehydrogenase FK536_RS11995 ENOG4108WFR AraC Family Transcriptional Regulator FK536_RS12000 ENOG4105WXT Conserved Protein FK536_RS12005 ENOG410689M (LipO)protein FK536_RS12010 ENOG4107H52 Dicarboxylate transport FK536_RS12015 ENOG4105C5I Dehydrogenase FK536_RS12020 ENOG41090X5 Heat shock protein hslJ FK536_RS12025 ENOG4105IKK cytoplasmic protein FK536_RS12030 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) FK536_RS12035 ENOG4105FCK Membrane FK536_RS12040 ENOG4108RW8 Universal stress protein F FK536_RS12050 ENOG4105C1J atp-dependent rna helicase FK536_RS12060 ENOG4105BZU Histidine kinase FK536_RS12065 ENOG4108DG9 Smr protein MutS2 FK536_RS12070 ENOG4106KR7 LysR family Transcriptional regulator FK536_RS12075 ENOG4105CH2 amidohydrolase FK536_RS12080 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B FK536_RS12085 ENOG4105CFC Transporter FK536_RS12090 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FK536_RS12095 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FK536_RS12100 ENOG4105Q9Y Universal stress protein FK536_RS12105 ENOG4105S5I Membrane FK536_RS12110 ENOG4105D64 Mechanosensitive ion channel FK536_RS12115 ENOG4107QSI ABC, transporter FK536_RS12125 ENOG4105ENX hydrolase FK536_RS12140 ENOG4105KXI murein peptide amidase A FK536_RS12145 ENOG4107S8C mandelate racemase muconate lactonizing FK536_RS12150 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FK536_RS12155 ENOG4108JU8 Transcriptional regulator FK536_RS12165 ENOG4105CM6 amino acid regulated cytosolic protein FK536_RS12170 ENOG4105FKQ transcriptional regulator FK536_RS12175 ENOG4107EFV Outer membrane protein G FK536_RS12180 ENOG4108IJ9 (ABC) transporter FK536_RS12185 ENOG4107URF beta-phospho-glucomutase FK536_RS12190 ENOG4105C71 hydrolase family 65, central catalytic FK536_RS12195 ENOG4105CK5 oxidoreductase FK536_RS12200 ENOG4107TYA transient receptor potential locus FK536_RS12205 ENOG4107RRD Dehydrogenase FK536_RS12210 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FK536_RS12215 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component FK536_RS12220 ENOG4105WEM extracellular solute-binding protein FK536_RS12225 ENOG4107QW3 Sucrose phosphorylase FK536_RS12230 ENOG4105K8Z Phage shock protein FK536_RS12235 ENOG4105NNG Peripheral inner membrane phage-shock protein FK536_RS12240 ENOG4105FM1 phage shock protein C FK536_RS12245 ENOG4105YYT phage shock protein B FK536_RS12250 ENOG41087YS Phage shock protein A FK536_RS12255 ENOG4105E51 psp operon transcriptional activator FK536_RS12260 ENOG4108JPW Aminotransferase FK536_RS12265 ENOG4105CJP fad dependent oxidoreductase FK536_RS12270 ENOG4105C26 Dehydrogenase FK536_RS12275 ENOG4107VRI Transcriptional regulator FK536_RS12280 ENOG4108Z86 Glutamine amidotransferase FK536_RS12285 ENOG4105CFQ glutamine synthetase FK536_RS12295 ENOG4105CUB amino acid FK536_RS12300 ENOG4105N0E Protein of unknown function (DUF2543) FK536_RS12305 ENOG4108HIY periplasmic FK536_RS12310 ENOG4108I5W peptide transport system, permease protein FK536_RS12315 ENOG4108EU3 peptide transport system, permease FK536_RS12320 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FK536_RS12325 ENOG4108JQ2 peptide transport system atp-binding protein FK536_RS12330 ENOG4105WDY DNA (cytosine-5-)-methyltransferase FK536_RS12335 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FK536_RS12340 ENOG4105Q4T oxidoreductase FK536_RS12355 ENOG4105BZU Histidine kinase FK536_RS12360 ENOG410643D UPF0509 protein FK536_RS12365 ENOG4105N2W Transcriptional regulator FK536_RS12375 ENOG4108ZJT translation initiation factor, Sui1 FK536_RS12380 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FK536_RS12385 ENOG4105CFV Tetratricopeptide repeat protein FK536_RS12390 ENOG4105Q4A inner membrane protein yciS FK536_RS12395 ENOG4105EYK Phosphatidylglycerophosphatase B FK536_RS12405 ENOG4107QM5 aconitate hydratase FK536_RS12425 ENOG4107R11 Transcriptional regulator FK536_RS12430 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FK536_RS12435 ENOG4105RKX Protein of unknown function (DUF2498) FK536_RS12440 ENOG4105ERU peptidase FK536_RS12445 ENOG4105UBK short-chain dehydrogenase reductase FK536_RS12450 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FK536_RS12455 ENOG4105FE9 pseudouridine synthase FK536_RS12460 ENOG4105EG3 transmembrane signal peptide protein FK536_RS12465 ENOG4107RTD sua5 ycio yrdc ywlc family protein FK536_RS12470 ENOG4105DB7 PHP domain protein FK536_RS12480 ENOG4105CRQ synthase (Component I) FK536_RS12485 ENOG4108EFP Anthranilate synthase component II FK536_RS12490 ENOG4105DK0 Indole-3-glycerol phosphate synthase FK536_RS12510 ENOG4108Z9Z response to DNA damage stimulus FK536_RS12515 ENOG4108N8X transition metal ion binding FK536_RS12520 ENOG4105EIF outer membrane protein W FK536_RS12530 ENOG4108S3I UPF0259 membrane protein FK536_RS12540 ENOG4105NAU thioesterase Superfamily protein FK536_RS12545 ENOG410822N TonB family FK536_RS12550 ENOG4105K9H YciI-like protein FK536_RS12555 ENOG4107SVH Potassium channel protein FK536_RS12575 ENOG4108JQ7 (ABC) transporter FK536_RS12580 ENOG4105C3U ABC transporter FK536_RS12585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FK536_RS12590 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FK536_RS12595 ENOG4108J59 Extracellular solute-binding protein, family 5 FK536_RS12605 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FK536_RS12610 ENOG4105C0A alcohol dehydrogenase FK536_RS12620 ENOG4107104 thymidine kinase FK536_RS12625 ENOG4108SAU DNA-binding protein H-ns FK536_RS12630 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FK536_RS12635 ENOG4105I93 response regulator FK536_RS12640 ENOG4105D78 K07001 NTE family protein FK536_RS12645 ENOG4105K5B UPF0225 protein FK536_RS12650 ENOG4105CIY formyltetrahydrofolate deformylase FK536_RS12685 ENOG41076YT nitrate reductase, gamma subunit FK536_RS12690 ENOG4105R3A Nitrate reductase FK536_RS12695 ENOG4108IUE nitrate reductase beta subunit FK536_RS12700 ENOG4105CRU nitrate reductase, alpha subunit FK536_RS12705 ENOG4105DQQ Major facilitator superfamily MFS_1 FK536_RS12710 ENOG4105BZU Histidine kinase FK536_RS12715 ENOG4105WH1 Two component transcriptional regulator luxr family FK536_RS12720 ENOG4105ID0 Putative invasin FK536_RS12725 ENOG41090EX DsrE family FK536_RS12730 ENOG4108NH8 Cation transport protein FK536_RS12735 ENOG4105WS7 Cation transport regulator FK536_RS12740 ENOG4105EWV Sodium calcium exchanger membrane region FK536_RS12765 ENOG41063JG Transcriptional regulator FK536_RS12770 ENOG4108YY7 Invasion gene expression up-regulator SirB FK536_RS12775 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FK536_RS12785 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FK536_RS12800 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FK536_RS12805 ENOG4105CHH sulfate transporter FK536_RS12810 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria FK536_RS12820 ENOG4105C3G gtp-binding protein FK536_RS12825 ENOG4105I1J Autotransporter FK536_RS12830 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FK536_RS12835 ENOG4105CMT Dihydroxyacetone kinase FK536_RS12840 ENOG4108UTZ Dihydroxyacetone kinase FK536_RS12845 ENOG4105VDH Dihydroxyacetone kinase FK536_RS12865 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) FK536_RS12870 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division FK536_RS12875 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FK536_RS12885 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FK536_RS12895 ENOG4105ED1 spovr family FK536_RS12910 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FK536_RS12915 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FK536_RS12920 ENOG4105KT5 UmuD protein FK536_RS12935 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FK536_RS12945 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium FK536_RS12950 ENOG4105S66 prophage protein FK536_RS12955 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FK536_RS12960 ENOG4107QMS site-determining protein FK536_RS12995 ENOG410658X FK536_RS13010 ENOG4105BZU Histidine kinase FK536_RS13015 ENOG410738I uncharacterized protein ymgC FK536_RS13025 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB FK536_RS13030 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component FK536_RS13040 ENOG4108XDN Transcriptional regulator FK536_RS13045 ENOG41064WM Uncharacterized protein YcgX FK536_RS13055 ENOG41066T8 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity) FK536_RS13060 ENOG4108HMX isocitrate dehydrogenase (NADP) FK536_RS13065 ENOG4108R99 pseudouridine synthase FK536_RS13085 ENOG4107QTF adenylosuccinate lyase FK536_RS13090 ENOG4105XJC Two component transcriptional regulator (Winged helix family FK536_RS13095 ENOG4105IFJ Histidine kinase FK536_RS13100 ENOG4105EZE Cupin 4 family protein FK536_RS13105 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FK536_RS13110 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FK536_RS13120 ENOG4105D38 putrescine abc transporter FK536_RS13125 ENOG4107RUE extracellular solute-binding protein family 1 FK536_RS13140 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FK536_RS13150 ENOG4105D60 lipoprotein releasing system transmembrane protein FK536_RS13155 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FK536_RS13160 ENOG4105D60 lipoprotein releasing system transmembrane protein FK536_RS13165 ENOG4105IQC Inner membrane protein YcfT FK536_RS13170 ENOG4108JA2 transcriptioN-repair coupling factor FK536_RS13175 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FK536_RS13180 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FK536_RS13185 ENOG4108IND Tetr family transcriptional regulator FK536_RS13190 ENOG4107MBR 17 kDa surface antigen FK536_RS13195 ENOG4105CEP NADH dehydrogenase FK536_RS13205 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) FK536_RS13210 ENOG4108RUM thiamine kinase FK536_RS13215 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) FK536_RS13220 ENOG41090DQ Lipoprotein FK536_RS13225 ENOG4105K59 histidine triad (HIT) protein FK536_RS13230 ENOG4105CNM Receptor FK536_RS13235 ENOG4105CI1 PTS System FK536_RS13240 ENOG4105F8V Hydrolase, tatD family FK536_RS13245 ENOG4107QRG dna polymerase iii FK536_RS13255 ENOG4105HHA aminodeoxychorismate lyase FK536_RS13260 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FK536_RS13265 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FK536_RS13270 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FK536_RS13275 ENOG4105CHR reductase FK536_RS13280 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FK536_RS13300 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FK536_RS13305 ENOG4108UHJ MAF-like protein FK536_RS13310 ENOG4105EI2 Pseudouridine synthase FK536_RS13315 ENOG4107QQB Ribonuclease E FK536_RS13320 ENOG4105DTJ flagellar hook-associated protein FK536_RS13325 ENOG4105E1Q flagellar hook-associated protein FK536_RS13330 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FK536_RS13335 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) FK536_RS13345 ENOG4105CGA flagellar basal-body rod protein FlgG FK536_RS13350 ENOG4108KPB Flagellar basal-body rod protein FlgF FK536_RS13355 ENOG4105BZE flagellar hook protein, FlgE FK536_RS13360 ENOG4105W00 Flagellar hook capping protein FK536_RS13365 ENOG4108ZC9 flagellar basal-body rod protein flgc FK536_RS13370 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FK536_RS13375 ENOG4105CKS Flagella basal body P-ring formation protein flgA FK536_RS13380 ENOG4105M9M anti-sigma28 factor FlgM FK536_RS13385 ENOG4105QVD Flagella synthesis protein FlgN FK536_RS13390 ENOG4105CJR Integral membrane protein (MviN FK536_RS13395 ENOG4105EP9 oxidoreductase FK536_RS13405 ENOG4105D9U N-acetyltransferase FK536_RS13415 ENOG4105E9S glutaredoxin 2 FK536_RS13420 ENOG4105F3T (LipO)protein FK536_RS13430 ENOG4105MEA DNA damage-inducible protein i FK536_RS13435 ENOG4105PVA Biofilm formation regulatory protein BssS FK536_RS13440 ENOG4105F76 Sarcosine oxidase FK536_RS13445 ENOG4106974 biofilm formation FK536_RS13450 ENOG4105DS1 cytochrome b561 FK536_RS13455 ENOG4108YYC ycei family FK536_RS13465 ENOG4105D1S lipid A biosynthesis FK536_RS13470 ENOG4105C6X Major Facilitator FK536_RS13475 ENOG4108W47 Acidic protein msyB FK536_RS13480 ENOG4105NAC (LipO)protein FK536_RS13485 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) FK536_RS13495 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) FK536_RS13500 ENOG4107RZC phospholipase d FK536_RS13505 ENOG4108UVJ appr-1-p processing domain protein FK536_RS13520 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin FK536_RS13525 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers FK536_RS13530 ENOG41086KC Transcriptional regulator FK536_RS13535 ENOG4108XDW curli assembly protein CsgE FK536_RS13540 ENOG4108WYR Curli production assembly transport component, CsgF FK536_RS13545 ENOG4105P8Q Curli production assembly transport component CsgG FK536_RS13550 ENOG4108UQ5 membrane protein YcdZ FK536_RS13555 ENOG4107XHZ cytoplasmic chaperone TorD family protein FK536_RS13565 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase FK536_RS13585 ENOG4105BZU Histidine kinase FK536_RS13590 ENOG4108TUY outer membrane protein PgaA FK536_RS13595 ENOG4107BJW polysaccharide deacetylase FK536_RS13600 ENOG4105CND Glycosyl transferase, family 2 FK536_RS13610 ENOG4105D5M phosphate starvation-inducible protein FK536_RS13615 ENOG4105DBE peroxidase FK536_RS13620 ENOG410650H (LipO)protein FK536_RS13630 ENOG4105CK7 Sodium proline symporter FK536_RS13640 ENOG4105C26 Dehydrogenase FK536_RS13645 ENOG4108R86 Transcriptional regulator FK536_RS13650 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) FK536_RS13655 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) FK536_RS13665 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FK536_RS13670 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) FK536_RS13675 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) FK536_RS13680 ENOG4105C2W permease FK536_RS13685 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 FK536_RS13695 ENOG4105XH3 FK536_RS13700 ENOG4105D6F Phosphatase FK536_RS13725 ENOG4107QY8 reductase FK536_RS13730 ENOG4105CUW cytochrome C-TYPE protein FK536_RS13735 ENOG4106WF9 DNA-binding transcriptional regulator TorR FK536_RS13740 ENOG4108SV3 Tmao reductase system periplasmic protein tort FK536_RS13745 ENOG4105BZU Histidine kinase FK536_RS13750 ENOG4105HEE Binding Domain protein FK536_RS13755 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation FK536_RS13770 ENOG4105VEQ Cold shock protein FK536_RS13775 ENOG41060EU Cold shock-like protein FK536_RS13785 ENOG4108Y9B (LipO)protein FK536_RS13790 ENOG4108W78 Pfam:DUF1017 FK536_RS13795 ENOG4105E3R (LipO)protein FK536_RS13800 ENOG4105DAY polysaccharide export protein FK536_RS13805 ENOG4107ZF2 Phosphatase FK536_RS13810 ENOG4105D75 Capsular exopolysaccharide family FK536_RS13815 ENOG4105D6F Phosphatase FK536_RS13825 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FK536_RS13830 ENOG4105C4M (Ubiquinol oxidase) subunit I FK536_RS13835 ENOG4105MVP hydrogenase-1 operon protein HyaF FK536_RS13840 ENOG4108VXY Hydrogenase-1 operon protein HyaE FK536_RS13845 ENOG4108USZ hydrogenase FK536_RS13850 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit FK536_RS13855 ENOG4105DPX Hydrogenase, large subunit FK536_RS13860 ENOG4105E3S small subunit FK536_RS13870 ENOG4108MN8 Membrane FK536_RS13875 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FK536_RS13880 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FK536_RS13895 ENOG4105K4P CoA-binding domain protein FK536_RS13910 ENOG41088T4 Helicase IV FK536_RS13915 ENOG410901E Membrane FK536_RS13920 ENOG4105EM2 membrane FK536_RS13925 ENOG4108RZ1 DNA transformation protein FK536_RS13935 ENOG4105UYK outer membrane protein a FK536_RS13945 ENOG4105DAN ATP-dependent protease FK536_RS13955 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) FK536_RS13960 ENOG4108Q2G (LipO)protein FK536_RS13965 ENOG4105DY2 Paraquat-inducible protein b FK536_RS13970 ENOG4105F1S paraquat-inducible protein a FK536_RS13975 ENOG4105C5H ABC transporter FK536_RS13985 ENOG4105QVC MOSC domain-containing protein FK536_RS13990 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FK536_RS14000 ENOG4106PH7 chaperone FK536_RS14005 ENOG4105MX3 Fimbrial FK536_RS14010 ENOG4105Q7J Fimbrial FK536_RS14015 ENOG4108MDY Fimbrial FK536_RS14020 ENOG4105CW0 outer membrane usher protein FK536_RS14025 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae FK536_RS14030 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon FK536_RS14035 ENOG4108UZX fmn reductase FK536_RS14040 ENOG4105GVF (ABC) transporter FK536_RS14050 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FK536_RS14055 ENOG4105E2Y ABC, transporter FK536_RS14060 ENOG4105CD8 aminopeptidase N FK536_RS14065 ENOG4107RH7 Nicotinate phosphoribosyltransferase FK536_RS14075 ENOG4105FCK Membrane FK536_RS14080 ENOG4105CGF Aromatic amino acid aminotransferase FK536_RS14085 ENOG4105C5X domain protein FK536_RS14090 ENOG4105EAQ (twin-arginine translocation) pathway signal FK536_RS14095 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FK536_RS14100 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) FK536_RS14105 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FK536_RS14115 ENOG4106371 Methyltransferase FK536_RS14120 ENOG4107S90 membrAne FK536_RS14125 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups FK536_RS14140 ENOG4105T0Z Conserved Protein FK536_RS14145 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FK536_RS14150 ENOG4105BZ1 (ABC) transporter FK536_RS14165 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FK536_RS14175 ENOG4108K0D peptidase, M48 FK536_RS14185 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FK536_RS14190 ENOG4107VMU Membrane FK536_RS14195 ENOG4105DDY UPF0142 protein ycaO FK536_RS14200 ENOG4105TMB Formate nitrite transporter FK536_RS14205 ENOG4105C6N Formate acetyltransferase FK536_RS14210 ENOG4105F1A Pyruvate formate-lyase FK536_RS14220 ENOG4108X0B nad(p)h dehydrogenase (quinone) FK536_RS14225 ENOG410642W LysR family Transcriptional regulator FK536_RS14230 ENOG4105E5D amino acid FK536_RS14240 ENOG4105CHJ isochorismatase hydrolase FK536_RS14245 ENOG4107KGK dmso reductase anchor subunit FK536_RS14250 ENOG4105QAX Iron-sulfur FK536_RS14255 ENOG4107QY8 reductase FK536_RS14265 ENOG4105D1H recombination factor protein RarA FK536_RS14275 ENOG4105CNU cell division protein FtsK FK536_RS14285 ENOG4105C3M thioredoxin reductase FK536_RS14290 ENOG4108JJ9 ABC, transporter FK536_RS14295 ENOG4108JJ8 (ABC) transporter FK536_RS14305 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FK536_RS14315 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FK536_RS14325 ENOG4105VEQ Cold shock protein FK536_RS14330 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FK536_RS14335 ENOG4105DJY efflux transporter, rnd family, mfp subunit FK536_RS14340 ENOG4108MJ5 VirK protein FK536_RS14345 ENOG4105CPB ATP-dependent endonuclease of the OLD family FK536_RS14350 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FK536_RS14355 ENOG4105DWU Membrane FK536_RS14365 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FK536_RS14370 ENOG4105C7K acetolactate synthase FK536_RS14375 ENOG4105C5W Aldolase FK536_RS14380 ENOG4105CGD Nad-dependent epimerase dehydratase FK536_RS14385 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FK536_RS14390 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FK536_RS14400 ENOG41064MM (LipO)protein FK536_RS14405 ENOG4105E5Z arginine transporter ATP-binding subunit FK536_RS14410 ENOG4106PMH Extracellular solute-binding protein family 3 FK536_RS14415 ENOG4105GBT ABC transporter FK536_RS14420 ENOG4105DMR ABC, transporter FK536_RS14425 ENOG4106TNF Periplasmic binding protein FK536_RS14430 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) FK536_RS14435 ENOG4105RBQ inner membrane protein ybjO FK536_RS14440 ENOG4105D38 putrescine abc transporter FK536_RS14445 ENOG4105F38 ABC transporter, permease FK536_RS14450 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FK536_RS14455 ENOG4107RUE extracellular solute-binding protein family 1 FK536_RS14460 ENOG4108RMJ sensory transduction regulator FK536_RS14475 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress FK536_RS14480 ENOG41090BQ Glutaredoxin FK536_RS14485 ENOG4105GWF inner membrane protein YbjM FK536_RS14495 ENOG4108RFG Tetr family transcriptional regulator FK536_RS14500 ENOG4106UW1 Major Facilitator superfamily FK536_RS14505 ENOG4108HCJ Hydrolase FK536_RS14515 ENOG4107QF7 multi-drug FK536_RS14520 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FK536_RS14525 ENOG4107FB0 transcriptional regulator DeoR family FK536_RS14530 ENOG4105DZ1 carboxypeptidase FK536_RS14535 ENOG4108TGY Glutathione S-transferase FK536_RS14540 ENOG4105D8V Glucose sorbosone dehydrogenase FK536_RS14545 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway FK536_RS14555 ENOG41064RH membrane protein YliF FK536_RS14560 ENOG4105BZU Histidine kinase FK536_RS14565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FK536_RS14575 ENOG4105DEF Extracellular solute-binding protein, family 5 FK536_RS14580 ENOG4108JQ6 ABC transporter FK536_RS14585 ENOG4105D44 asparaginase FK536_RS14590 ENOG4105CVM Molybdenum cofactor synthesis domain protein FK536_RS14595 ENOG4105D06 uba thif-type nad fad binding protein FK536_RS14600 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FK536_RS14605 ENOG4105F1A Pyruvate formate-lyase FK536_RS14615 ENOG4108HCJ Hydrolase FK536_RS14620 ENOG41072TH Protein of unknown function (DUF1479) FK536_RS14625 ENOG4105C5H ABC transporter FK536_RS14630 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FK536_RS14635 ENOG4105F4P )-transporter FK536_RS14640 ENOG4105KST dependent repressor FK536_RS14650 ENOG4108I6E Sulfatase FK536_RS14655 ENOG4108T1M outer membrane protein x FK536_RS14665 ENOG4107AQZ Membrane FK536_RS14675 ENOG4107R0W ABC transporter FK536_RS14680 ENOG4105E5Q amino acid AbC transporter FK536_RS14685 ENOG4105CDA abc transporter atp-binding protein FK536_RS14690 ENOG4105D8X mechanosensitive ion channel FK536_RS14700 ENOG4105ZY9 UPF0379 protein ybiM FK536_RS14705 ENOG4108IU3 tonb-dependent siderophore receptor FK536_RS14715 ENOG4105KSC Transcriptional regulator, TraR DksA family FK536_RS14720 ENOG4105VR4 UPF0379 protein ybiJ FK536_RS14725 ENOG4105DG4 malate L-lactate dehydrogenase FK536_RS14730 ENOG4108MTB glycosyl transferase family FK536_RS14735 ENOG4105DVT helicase FK536_RS14740 ENOG4108UV1 cellular component movement FK536_RS14745 ENOG4105C1J atp-dependent rna helicase FK536_RS14750 ENOG4107MVR Transcriptional regulator FK536_RS14760 ENOG4105CJ1 ABC, transporter FK536_RS14765 ENOG4107QWP ABC-2 type transporter FK536_RS14770 ENOG4107QWP ABC-2 type transporter FK536_RS14775 ENOG4105I9U inner membrane protein ybhQ FK536_RS14780 ENOG4105X23 Endonuclease Exonuclease phosphatase FK536_RS14785 ENOG4105DZQ phospholipase D Transphosphatidylase FK536_RS14790 ENOG4107UXM Membrane FK536_RS14795 ENOG410733J conserved inner membrane protein FK536_RS14800 ENOG4105HFZ Membrane FK536_RS14805 ENOG4108ZAF Molybdopterin FK536_RS14810 ENOG4105M00 molybdopterin converting factor, subunit 1 FK536_RS14820 ENOG4108RIR Molybdenum cofactor biosynthesis protein FK536_RS14830 ENOG4105CHW UPF0052 protein FK536_RS14840 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FK536_RS14845 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FK536_RS14850 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FK536_RS14860 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FK536_RS14865 ENOG4108V1U phospholipid-binding protein FK536_RS14870 ENOG4105NBR Pectinesterase FK536_RS14875 ENOG4107QM5 aconitate hydratase FK536_RS14880 ENOG4107QPK )-transporter FK536_RS14885 ENOG4105C7F AcnD-accessory protein PrpF FK536_RS14890 ENOG4105F04 LysR family Transcriptional regulator FK536_RS14900 ENOG4108K4B hydrolase FK536_RS14905 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FK536_RS14910 ENOG4105E0C molybdate abc transporter FK536_RS14915 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FK536_RS14925 ENOG4105F4R Transcriptional regulator mode FK536_RS14930 ENOG4105DKW ABC transporter FK536_RS14935 ENOG4105CMR udp-glucose 4-epimerase FK536_RS14940 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FK536_RS14950 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FK536_RS14960 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FK536_RS14965 ENOG4105JND homeobox protein FK536_RS14970 ENOG4105PGM cation diffusion facilitator family transporter FK536_RS14975 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FK536_RS14980 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FK536_RS15020 ENOG4105UFD tol-pal system protein YbgF FK536_RS15025 ENOG4105KCK Peptidoglycan-associated lipoprotein FK536_RS15035 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FK536_RS15045 ENOG4105E02 MotA TolQ exbB proton channel FK536_RS15050 ENOG4107YD3 Thioesterase FK536_RS15055 ENOG4105KJB cyd operon protein YbgE FK536_RS15065 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FK536_RS15070 ENOG4105C4M (Ubiquinol oxidase) subunit I FK536_RS15080 ENOG4105C8I hydrolase, family 38 FK536_RS15085 ENOG4105DM4 PTS System FK536_RS15090 ENOG4105FDP GntR family transcriptional regulator FK536_RS15095 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FK536_RS15105 ENOG4105C7S Dehydrogenase FK536_RS15110 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FK536_RS15115 ENOG4105E33 succinate dehydrogenase FK536_RS15120 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FK536_RS15125 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FK536_RS15130 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FK536_RS15140 ENOG4105BZN citrate synthase FK536_RS15145 ENOG4106UBK fimbrial-like adhesin protein FK536_RS15150 ENOG4106PG1 outer membrane usher protein FK536_RS15155 ENOG4108TTM chaperone FK536_RS15160 ENOG4108MY7 Fimbrial FK536_RS15165 ENOG4108KK1 membrane protein AbrB duplication FK536_RS15175 ENOG4105E7W lamb ycsf family protein FK536_RS15180 ENOG4107R7A Allophanate hydrolase subunit 2 FK536_RS15185 ENOG4105P4J Allophanate hydrolase, subunit 1 FK536_RS15190 ENOG4107QNR UPF0135 protein FK536_RS15195 ENOG4105DUX Transporter FK536_RS15200 ENOG4105CVP deoxyribo-dipyrimidine photolyase FK536_RS15205 ENOG4107SEY Conserved Protein FK536_RS15225 ENOG4105XIQ Protein of unknown function (DUF2517) FK536_RS15240 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FK536_RS15245 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FK536_RS15250 ENOG4105C08 Histidine kinase FK536_RS15255 ENOG4105EEX Two component transcriptional regulator (Winged helix family FK536_RS15265 ENOG4105CXN decarboxylase FK536_RS15270 ENOG4105D5Q Arginine ornithine antiporter FK536_RS15290 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FK536_RS15295 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) FK536_RS15300 ENOG4105EV9 Alpha Beta Hydrolase FK536_RS15305 ENOG4105NNH LexA regulated protein FK536_RS15310 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FK536_RS15320 ENOG41090R7 Ferric uptake FK536_RS15325 ENOG4105GX6 (LipO)protein FK536_RS15340 ENOG4105CI1 PTS System FK536_RS15350 ENOG4105CE4 GlcNAc 6-P deacetylase FK536_RS15355 ENOG4105E2R ROK family FK536_RS15360 ENOG4105D4U had-superfamily hydrolase, subfamily iia FK536_RS15365 ENOG4105CAQ asparagine synthetase FK536_RS15405 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FK536_RS15415 ENOG4105C9A Phoh family FK536_RS15425 ENOG4108JU5 Magnesium and cobalt efflux protein FK536_RS15430 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FK536_RS15435 ENOG4107RP9 extracellular solute-binding protein, family 3 FK536_RS15440 ENOG4105EAD ABC transporter FK536_RS15445 ENOG4105DRP amino acid AbC transporter FK536_RS15450 ENOG4105CDA abc transporter atp-binding protein FK536_RS15465 ENOG4105EUU Sel1 domain protein repeat-containing protein FK536_RS15470 ENOG4107PAI alpha helical protein FK536_RS15485 ENOG4105DJF DNA polymerase III, delta' subunit FK536_RS15495 ENOG4108TGR phosphatase FK536_RS15500 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FK536_RS15510 ENOG4105CJN penicillin-binding protein FK536_RS15515 ENOG4105CNI cell division protein FtsW FK536_RS15520 ENOG4105K6T rare lipoprotein A FK536_RS15525 ENOG4105DZ1 carboxypeptidase FK536_RS15560 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) FK536_RS15580 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) FK536_RS15585 ENOG4105CEE C4-dicarboxylate transporter FK536_RS15590 ENOG4106YYS transcriptional regulatory protein FK536_RS15595 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FK536_RS15600 ENOG4105DUA (citrate (pro-3S)-lyase ligase FK536_RS15610 ENOG4105CI0 Citrate lyase FK536_RS15615 ENOG4105CHY citrate lyase, alpha FK536_RS15630 ENOG4107QPK )-transporter FK536_RS15635 ENOG4105KTS ribonuclease FK536_RS15640 ENOG4105NXH GreA GreB family elongation factor FK536_RS15645 ENOG4105E2A Dehydrogenase FK536_RS15650 ENOG4108U51 Universal stress protein FK536_RS15655 ENOG4108JU3 Alkyl hydroperoxide reductase FK536_RS15660 ENOG4105D3R alkyl hydroperoxide reductase FK536_RS15665 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FK536_RS15670 ENOG4105DQS Transcriptional regulator FK536_RS15675 ENOG4105BZV Phosphoadenosine phosphosulfate reductase FK536_RS15680 ENOG4105GTN ParB Domain Protein Nuclease FK536_RS15685 ENOG4105CHM Aminotransferase FK536_RS15690 ENOG4107SCQ Iron-containing alcohol dehydrogenase FK536_RS15695 ENOG4105VCD cytoplasmic protein FK536_RS15700 ENOG4105D22 carbon starvation protein FK536_RS15705 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) FK536_RS15710 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FK536_RS15715 ENOG4105WQI isochorismatase FK536_RS15720 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FK536_RS15725 ENOG4105E4F Isochorismate synthase FK536_RS15730 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein FK536_RS15740 ENOG4105DQ5 transport system permease protein FK536_RS15745 ENOG4105TVJ transport system, permease FK536_RS15750 ENOG4105E0A ABC, transporter FK536_RS15755 ENOG4108QY5 Ferric enterobactin transport protein FK536_RS15760 ENOG4105C0W non-ribosomal peptide synthetase FK536_RS15765 ENOG41085A6 mbth domain-containing protein FK536_RS15770 ENOG4105E93 esterase FK536_RS15775 ENOG4107RNH Outer membrane receptor FepA FK536_RS15780 ENOG4108TSE Transferase FK536_RS15785 ENOG4108SER Transposase FK536_RS15790 ENOG4107635 Hok Gef family protein FK536_RS15800 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) FK536_RS15805 ENOG4105WQ6 Membrane FK536_RS15810 ENOG4105MSB protein, conserved in bacteria FK536_RS15815 ENOG4108RCM Nitroreductase FK536_RS15820 ENOG4105CUY Mechanosensitive ion channel FK536_RS15825 ENOG4105C85 amino acid FK536_RS15830 ENOG4108IJF Heavy metal efflux pump, CzcA FK536_RS15835 ENOG4105EP1 Efflux transporter rnd family, mfp subunit FK536_RS15840 ENOG410624V efflux system protein FK536_RS15845 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FK536_RS15850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FK536_RS15855 ENOG4105GR3 Histidine kinase FK536_RS15875 ENOG4108Q9V regulatoR FK536_RS15880 ENOG4108ZI2 Fimbrial protein FK536_RS15885 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) FK536_RS15890 ENOG4105CW0 outer membrane usher protein FK536_RS15895 ENOG4108AF8 Chaperone FK536_RS15900 ENOG4108WDE Fimbrial protein FK536_RS15905 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FK536_RS15910 ENOG4105WQ3 Rna-binding protein FK536_RS15915 ENOG4105S2T inner membrane protein YbcI FK536_RS15925 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FK536_RS15935 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FK536_RS15940 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FK536_RS15945 ENOG4105C5B carbamate kinase FK536_RS15950 ENOG4105G5A Protein of unknown function (DUF2877) FK536_RS15955 ENOG4107REC cytoplasmic protein FK536_RS15960 ENOG4107R1Q Membrane protein FdrA FK536_RS15965 ENOG4105DG4 malate L-lactate dehydrogenase FK536_RS15970 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FK536_RS15975 ENOG4105S0E allantoin catabolism protein FK536_RS15980 ENOG4105BZW Glycerate kinase FK536_RS15985 ENOG4105DTE Xanthine uracil vitamin C permease FK536_RS15990 ENOG4105CD3 dihydroorotase FK536_RS16000 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FK536_RS16005 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FK536_RS16010 ENOG41060W2 glyoxylate carboligase FK536_RS16015 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region FK536_RS16025 ENOG4107653 Transcriptional regulator FK536_RS16030 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) FK536_RS16060 ENOG4105CNA YD repeat protein FK536_RS16065 ENOG4105CV6 ABC transporter, permease FK536_RS16070 ENOG4108I0Y (ABC) transporter FK536_RS16075 ENOG4108UJV acyl-CoA thioesterase i FK536_RS16080 ENOG4105E1F short-chain dehydrogenase reductase FK536_RS16085 ENOG4107QR8 Thioredoxin FK536_RS16090 ENOG4105C4B ABC transporter, permease FK536_RS16095 ENOG41083J0 (ABC) transporter FK536_RS16100 ENOG4107QX8 SPFH domain, Band 7 family protein FK536_RS16105 ENOG4105G5H Membrane FK536_RS16110 ENOG4108Z6Z Transcriptional regulator FK536_RS16115 ENOG4107RY6 amino acid FK536_RS16120 ENOG4105CSV Glutaminase FK536_RS16125 ENOG4105C59 p-type ATPase FK536_RS16130 ENOG41081XE plasmid maintenance system antidote protein, xre family FK536_RS16135 ENOG4105MBR gumn family FK536_RS16140 ENOG4108Z66 YbaK ebsC protein FK536_RS16145 ENOG4105CGH 5'-nucleotidase FK536_RS16150 ENOG4105EU0 Major facilitator Superfamily FK536_RS16155 ENOG4105CKD glutathione-regulated potassium-efflux system protein FK536_RS16160 ENOG4107RE1 Inosine-guanosine kinase FK536_RS16170 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FK536_RS16195 ENOG4107QMP dna polymerase iii subunits gamma and tau FK536_RS16205 ENOG4105WD1 Membrane FK536_RS16210 ENOG4108URS primosomal replication protein n'' FK536_RS16215 ENOG4106428 Protein of unknown function (DUF2496) FK536_RS16220 ENOG4105EGS Mechanosensitive ion channel FK536_RS16225 ENOG4107XI7 Tetr family transcriptional regulator FK536_RS16230 ENOG4105C1P efflux transporter, rnd family, mfp subunit FK536_RS16235 ENOG4105BZS acriflavin resistance protein FK536_RS16240 ENOG4108UKR Biofilm formation regulator YbaJ FK536_RS16245 ENOG4105KF5 hemolysin expression-modulating protein FK536_RS16250 ENOG4108UW5 maltose o-acetyltransferase FK536_RS16255 ENOG4105GSJ Inner membrane protein ylaC FK536_RS16260 ENOG41066DG (EAL) domain protein FK536_RS16275 ENOG41080UX Methyltransferase FK536_RS16280 ENOG4108MNP Glycoprotein polysaccharide metabolism FK536_RS16285 ENOG4105C29 acyl-CoA thioesterase FK536_RS16290 ENOG4105BZU Histidine kinase FK536_RS16295 ENOG4108YZA Nitrogen regulatory protein pii FK536_RS16300 ENOG4105BZ1 (ABC) transporter FK536_RS16305 ENOG4105BZ1 (ABC) transporter FK536_RS16310 ENOG4108XM1 transcriptional regulator AsnC family FK536_RS16315 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) FK536_RS16320 ENOG4108NFA extracellular solute-binding protein FK536_RS16325 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FK536_RS16330 ENOG4108TGP Thioesterase superfamily protein FK536_RS16335 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FK536_RS16340 ENOG4105EIN peptidylprolyl cis-trans isomerase FK536_RS16345 ENOG4105K70 DNA-binding protein FK536_RS16350 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FK536_RS16370 ENOG4105M85 Bola protein FK536_RS16375 ENOG4105IEY (LipO)protein FK536_RS16380 ENOG4105EYM Major Facilitator superfamily FK536_RS16385 ENOG4105E2S oxidase) subunit II FK536_RS16390 ENOG4105BZ9 Cytochrome C oxidase, subunit I FK536_RS16395 ENOG4105CCU oxidase (Subunit III) FK536_RS16400 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FK536_RS16410 ENOG4107RDB Major Facilitator FK536_RS16420 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FK536_RS16425 ENOG4107S0N DJ-1 family FK536_RS16430 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FK536_RS16440 ENOG4105CTB Polyprenyl synthetase FK536_RS16445 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FK536_RS16450 ENOG4105CPC Aldo Keto reductase FK536_RS16455 ENOG4108ZAI phosphatidylglycerophosphatase a FK536_RS16460 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FK536_RS16470 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FK536_RS16475 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FK536_RS16485 ENOG4108KIC (LipO)protein FK536_RS16490 ENOG4105DRB nucleoside-specific channel-forming protein FK536_RS16495 ENOG4105N1F Hnh endonuclease FK536_RS16500 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FK536_RS16505 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FK536_RS16510 ENOG4105VIE preprotein translocase, subunit YajC FK536_RS16525 ENOG4108ZYK Acyl carrier protein phosphodiesterase FK536_RS16530 ENOG4107R28 alpha amylase, catalytic region FK536_RS16535 ENOG4105C85 amino acid FK536_RS16540 ENOG4105CWM branched-chain amino acid transport system II carrier protein FK536_RS16545 ENOG4105BZU Histidine kinase FK536_RS16550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FK536_RS16555 ENOG4107RH8 nuclease SbcCD subunit D FK536_RS16560 ENOG4105EYH Exonuclease FK536_RS16565 ENOG4105F27 Major Facilitator FK536_RS16570 ENOG4105DKQ ROK family FK536_RS16595 ENOG4105HBA AroM protein FK536_RS16600 ENOG4105SS3 FK536_RS16610 ENOG4108UPT UPF0178 protein FK536_RS16615 ENOG4105II7 pyrroline-5-carboxylate reductase FK536_RS16620 ENOG4105BZU Histidine kinase FK536_RS16625 ENOG4105VIF phosphate starvation-inducible protein FK536_RS16630 ENOG4105G6Z alkaline phosphatase FK536_RS16645 ENOG4105CPF Cell wall formation (By similarity) FK536_RS16650 ENOG4105UNH Membrane FK536_RS16655 ENOG4105FR5 inner membrane protein YaiY FK536_RS16660 ENOG4107QS8 (LipO)protein FK536_RS16665 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 FK536_RS16670 ENOG4107R6D beta-lactam binding protein AmpH FK536_RS16675 ENOG4108PNB DNA-binding transcriptional regulator FK536_RS16695 ENOG4105D52 delta-aminolevulinic acid dehydratase FK536_RS16700 ENOG4105E2B Taurine dioxygenase FK536_RS16705 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FK536_RS16710 ENOG4108ETV ABC transporter FK536_RS16715 ENOG4106FTQ Taurine ABC transporter, periplasmic FK536_RS16725 ENOG4107W19 lmbE family FK536_RS16730 ENOG4108PBI Polysaccharide metabolism FK536_RS16740 ENOG4105SRB Uncharacterized protein yaiO FK536_RS16755 ENOG4105C4W S-formylglutathione hydrolase FK536_RS16760 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FK536_RS16765 ENOG4108SC4 )-transporter FK536_RS16780 ENOG4105IKQ hydratase FK536_RS16785 ENOG4106HB6 Alpha beta hydrolase FK536_RS16795 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase FK536_RS16800 ENOG4108K2P TRANSCRIPTIONal FK536_RS16805 ENOG4105ETE Transcriptional regulator (LacI family FK536_RS16810 ENOG4105CNT hydrolase family 2 FK536_RS16815 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FK536_RS16820 ENOG4108UW5 maltose o-acetyltransferase FK536_RS16825 ENOG4105DJ2 Major Facilitator Superfamily FK536_RS16830 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FK536_RS16835 ENOG4107B2H carbonic anhydrase FK536_RS16840 ENOG4105DND Transcriptional regulator FK536_RS16845 ENOG4105DZC cytosine deaminase FK536_RS16850 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FK536_RS16855 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FK536_RS16860 ENOG4105DXD 2-methylcitrate dehydratase FK536_RS16865 ENOG4105BZN citrate synthase FK536_RS16870 ENOG4105CR4 methylisocitrate lyase FK536_RS16875 ENOG4108JU7 Transcriptional regulator FK536_RS16880 ENOG4105TDT uncharacterized protein yahO FK536_RS16890 ENOG4105E82 cytochrome subunit of dehydrogenase FK536_RS16905 ENOG4105DQ4 alcohol dehydrogenase FK536_RS16910 ENOG4105DZC cytosine deaminase FK536_RS16915 ENOG4105C5B carbamate kinase FK536_RS16925 ENOG4107REC cytoplasmic protein FK536_RS16930 ENOG4107R1Q Membrane protein FdrA FK536_RS16935 ENOG4105N16 Protein of unknown function (DUF2877) FK536_RS16940 ENOG4107SNB ankyrin repeat protein YahD FK536_RS16945 ENOG4105SZ2 membrAne FK536_RS16950 ENOG4108NUU Transcriptional regulator FK536_RS16955 ENOG4105BZU Histidine kinase FK536_RS16970 ENOG4105C94 Transporter FK536_RS16975 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FK536_RS16980 ENOG4105C26 Dehydrogenase FK536_RS16985 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FK536_RS16995 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FK536_RS17000 ENOG4107QR9 Iron-sulfur cluster binding protein FK536_RS17005 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FK536_RS17010 ENOG4108K01 transcriptional regulator FK536_RS17030 ENOG41066GK UPF0379 protein ykgI FK536_RS17035 ENOG4108KBJ Inner membrane protein YkgB FK536_RS17075 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon FK536_RS17080 ENOG4108GWT fimbrillin MatB FK536_RS17090 ENOG4108N3D putative enzyme FK536_RS17095 ENOG4106PYX Receptor FK536_RS17100 ENOG4108UD7 cell wall organization FK536_RS17105 ENOG4105PI0 Ferredoxin FK536_RS17110 ENOG4105R3P Inner membrane protein yagU FK536_RS17115 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FK536_RS17120 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FK536_RS17125 ENOG4105C7W Xanthine dehydrogenase FK536_RS17130 ENOG4107XAN XdhC and CoxI family FK536_RS17150 ENOG4105UZW Tail fiber assembly protein FK536_RS17155 ENOG4108X9F tail fiber protein FK536_RS17170 ENOG4105FKG DNA packaging protein FK536_RS17180 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 FK536_RS17225 ENOG4108KU3 Integrase FK536_RS17230 ENOG4105UZW Tail fiber assembly protein FK536_RS17240 ENOG4105EXC Acyl-transferase FK536_RS17270 ENOG4105RWQ Protein of unknown function (DUF1364) FK536_RS17275 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 FK536_RS17280 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi FK536_RS17300 ENOG4107TII Recombinase FK536_RS17310 ENOG410814C multidrug resistance protein FK536_RS17390 ENOG4105VDM plasmid maintenance system antidote protein, xre family FK536_RS17430 ENOG4108C33 Resolvase FK536_RS17440 ENOG4105PTU response to oxidative stress FK536_RS17445 ENOG4108US3 tail fiber assembly FK536_RS17450 ENOG4105Y9F tail fiber protein FK536_RS17455 ENOG4105Y0G tail protein FK536_RS17460 ENOG4108T86 baseplate J family protein FK536_RS17480 ENOG4108NKR DNA circulation protein FK536_RS17510 ENOG4105TKZ Tail Sheath FK536_RS17555 ENOG4105EFC phage portal protein HK97 family FK536_RS17565 ENOG4105CAR Terminase, large subunit FK536_RS17580 ENOG4105QYK bacteriophage lambda Bor protein homolog FK536_RS17615 ENOG4105HRS Antitermination protein FK536_RS17620 ENOG4108MXB Protein of unknown function (DUF968) FK536_RS17630 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) FK536_RS17655 ENOG4108S1U FK536_RS17660 ENOG41078CG DNA-binding transcriptional regulator FK536_RS17665 ENOG4105RDA repressor FK536_RS17680 ENOG4108R7K Metal Dependent Phosphohydrolase FK536_RS17685 ENOG41077V0 CPS-53 (KpLE1) prophage FK536_RS17695 ENOG4108KU3 Integrase FK536_RS17705 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FK536_RS17715 ENOG4105FCK Membrane FK536_RS17725 ENOG4105V1F Fermentation respiration switch protein FK536_RS17735 ENOG4105CIN aminoacyl-histidine dipeptidase FK536_RS17740 ENOG4108S2Y peptide Chain Release factor FK536_RS17750 ENOG4108HYG acetyltransferase FK536_RS17760 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome FK536_RS17765 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system FK536_RS17770 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FK536_RS17785 ENOG4108UK5 Transposase FK536_RS17790 ENOG4108YS0 lipoprotein YafL FK536_RS17795 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression FK536_RS17800 ENOG4105VXN addiction module toxin, RelE StbE family FK536_RS17805 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FK536_RS17810 ENOG4105E7A Glutamine amidotransferase FK536_RS17820 ENOG4107QPN acyl-Coa dehydrogenase FK536_RS17825 ENOG4108WN0 inhibitor of vertebrate lysozyme FK536_RS17830 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FK536_RS17835 ENOG410600T transposase FK536_RS17860 ENOG4105GMB type VI secretion system effector, hcp1 family FK536_RS17875 ENOG410600K aminopeptidase FK536_RS17885 ENOG4107RZZ dna polymerase iii epsilon subunit FK536_RS17895 ENOG4105D1A Methyltransferase FK536_RS17900 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FK536_RS17905 ENOG4105E9H Lytic Murein transglycosylase FK536_RS17920 ENOG4105HEI LysR family (Transcriptional regulator FK536_RS17925 ENOG4105CV8 reductase FK536_RS17960 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FK536_RS17965 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FK536_RS17970 ENOG4108UMI ABC transporter, permease FK536_RS17975 ENOG4105D01 (LipO)protein FK536_RS17980 ENOG4108R8X outer membrane lipoprotein FK536_RS17985 ENOG4108R96 Methyltransferase, YaeB family FK536_RS17995 ENOG4108UY0 (LipO)protein FK536_RS18000 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FK536_RS18005 ENOG4108YZN class I peptide chain release factor FK536_RS18010 ENOG4108VWS Yaeq family FK536_RS18020 ENOG4105M1T rho-binding antiterminator FK536_RS18025 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FK536_RS18030 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FK536_RS18035 ENOG4105CXN decarboxylase FK536_RS18045 ENOG4105C0B DNA polymerase III (alpha subunit) FK536_RS18070 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FK536_RS18075 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FK536_RS18085 ENOG4105DZP Membrane-associated zinc metalloprotease FK536_RS18090 ENOG4105KNE Phosphatidate cytidylyltransferase FK536_RS18095 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FK536_RS18100 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FK536_RS18125 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FK536_RS18130 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) FK536_RS18140 ENOG4105DIN metallophosphoesterase FK536_RS18150 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FK536_RS18155 ENOG4105C0H protease FK536_RS18170 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FK536_RS18175 ENOG4105EN6 Membrane FK536_RS18200 ENOG4105S6R Iron-hydroxamate transporter permease subunit FK536_RS18205 ENOG4105J76 Periplasmic binding protein FK536_RS18210 ENOG4105E0A ABC, transporter FK536_RS18215 ENOG4105E0K tonB-dependent siderophore receptor FK536_RS18220 ENOG4105BZ4 penicillin-binding protein FK536_RS18225 ENOG4105CQ7 ATP-dependent helicase FK536_RS18230 ENOG4107XID 2'-5' rna ligase FK536_RS18250 ENOG4105DJ0 Poly(A) Polymerase FK536_RS18255 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FK536_RS18265 ENOG4108VEV chaperone FK536_RS18285 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FK536_RS18295 ENOG4108A32 Transposase FK536_RS18305 ENOG4107BJW polysaccharide deacetylase FK536_RS18310 ENOG4108YTN IIa component FK536_RS18315 ENOG4105E3A (ABC) transporter FK536_RS18320 ENOG4105DA5 (ABC) transporter FK536_RS18325 ENOG41077A9 carbonic anhydrase FK536_RS18330 ENOG4108UGV hypoxanthine phosphoribosyltransferase FK536_RS18335 ENOG4105DZG Dehydrogenase FK536_RS18340 ENOG4105E3B Multicopper oxidase FK536_RS18345 ENOG4108ZRK uncharacterized protein yacC FK536_RS18365 ENOG4107QIJ Aconitate hydratase 2 FK536_RS18370 ENOG4108NST exported protein FK536_RS18375 ENOG4107QN2 dihydrolipoyl dehydrogenase FK536_RS18380 ENOG4107QSN dihydrolipoamide acetyltransferase FK536_RS18385 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FK536_RS18390 ENOG41073TP transcriptional regulator FK536_RS18395 ENOG4105C85 amino acid FK536_RS18400 ENOG4106A72 regulatory protein AmpE FK536_RS18405 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FK536_RS18410 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FK536_RS18415 ENOG4108ZUW Major pilin subunit FK536_RS18420 ENOG4107QHF type ii secretion system protein e FK536_RS18425 ENOG4105D7Q type ii secretion system FK536_RS18435 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FK536_RS18450 ENOG4105M6F mutator MutT protein FK536_RS18460 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) FK536_RS18470 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FK536_RS18475 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FK536_RS18480 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FK536_RS18485 ENOG4105CPF Cell wall formation (By similarity) FK536_RS18490 ENOG4105DFU Cell wall formation (By similarity) FK536_RS18495 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FK536_RS18500 ENOG4105CNI cell division protein FtsW FK536_RS18505 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FK536_RS18515 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FK536_RS18520 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FK536_RS18525 ENOG4105CJN penicillin-binding protein FK536_RS18530 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FK536_RS18540 ENOG4108V6E Cell division protein mraZ FK536_RS18545 ENOG4107B7Y DNA-binding transcriptional regulator FruR FK536_RS18555 ENOG4108ZP8 Acetolactate synthase small subunit FK536_RS18560 ENOG4105C7K acetolactate synthase FK536_RS18570 ENOG41064T2 transcriptional regulator, lysR family FK536_RS18590 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FK536_RS18605 ENOG4105S8Q sugar efflux transporter FK536_RS18615 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FK536_RS18620 ENOG4105DP9 ABC transporter FK536_RS18625 ENOG4106SMU thiamine transporter membrane protein FK536_RS18630 ENOG4107T0D ABC, transporter FK536_RS18635 ENOG4108KF1 Membrane FK536_RS18640 ENOG41063TF transcriptional regulator (AraC FK536_RS18645 ENOG4105EF1 ribulokinase FK536_RS18650 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FK536_RS18655 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FK536_RS18660 ENOG4105CQ2 DNA polymerase FK536_RS18665 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) FK536_RS18670 ENOG4105D3G Pseudouridine synthase FK536_RS18690 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FK536_RS18695 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FK536_RS18700 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FK536_RS18705 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FK536_RS18720 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FK536_RS18725 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FK536_RS18730 ENOG4105CKD glutathione-regulated potassium-efflux system protein FK536_RS18740 ENOG4105C54 Major Facilitator superfamily FK536_RS18745 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein FK536_RS18750 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FK536_RS18775 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FK536_RS18780 ENOG4105CEY Amp-dependent synthetase and ligase FK536_RS18785 ENOG4106YT9 Enoyl-CoA hydratase FK536_RS18790 ENOG4108Z0R Transferase FK536_RS18795 ENOG4108XNW Transcriptional activatory protein CaiF FK536_RS18800 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FK536_RS18805 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FK536_RS18825 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FK536_RS18840 ENOG4105DTN riboflavin biosynthesis protein ribF FK536_RS18845 ENOG410647N response to DNA damage stimulus FK536_RS18870 ENOG41063Z6 transcriptional regulator, lysR family FK536_RS18880 ENOG4105WI6 cell killing protein encoded within cryptic prophage FK536_RS18900 ENOG4108QUJ UPF0174 protein YaaW FK536_RS18905 ENOG4106HK8 GPR1 FUN34 yaaH family protein FK536_RS18910 ENOG4108RIR Molybdenum cofactor biosynthesis protein FK536_RS18920 ENOG4105BZG amino acid carrier protein FK536_RS18930 ENOG41062C6 Protein of unknown function (DUF2502) FK536_RS18935 ENOG4105D98 threonine synthase FK536_RS18945 ENOG4105CFH Aspartokinase FK536_RS18955 ENOG4106FVC RNA methyltransferase FK536_RS18960 ENOG410759A FK536_RS18965 ENOG41065U4 response regulator FK536_RS18970 ENOG4105CT7 inner membrane cred family protein FK536_RS18975 ENOG4105EB3 Histidine kinase FK536_RS18980 ENOG4105E3W Two component transcriptional regulator (Winged helix family FK536_RS18985 ENOG4108RH0 Crea protein FK536_RS18990 ENOG4105UEI Transcriptional Regulator AraC Family FK536_RS19000 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FK536_RS19010 ENOG4107SC1 transglycosylase FK536_RS19015 ENOG4105C5H ABC transporter FK536_RS19020 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase FK536_RS19025 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FK536_RS19030 ENOG4105EAC phosphoserine phosphatase FK536_RS19035 ENOG41062Z9 Membrane FK536_RS19050 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FK536_RS19070 ENOG4105G0K glycine radical enzyme YjjI family FK536_RS19075 ENOG41076CZ activating enzyme FK536_RS19080 ENOG4105EYA deoxyribonuclease FK536_RS19085 ENOG4108NRW Phospholipase, patatin family FK536_RS19095 ENOG4105K3G Periplasmic Protein FK536_RS19105 ENOG4105PAD Hydrolase FK536_RS19110 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FK536_RS19115 ENOG4108WPU DNA polymerase III subunit psi FK536_RS19120 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FK536_RS19140 ENOG4105YBH Protein of unknown function (DUF1435) FK536_RS19145 ENOG4108819 ferric iron reductase FK536_RS19150 ENOG4108T94 DNA-binding transcriptional activator BglJ FK536_RS19155 ENOG4108N8T regulatoR FK536_RS19160 ENOG4105DWK Membrane FK536_RS19175 ENOG4106CVF DNA replication protein FK536_RS19180 ENOG4105RI1 glycoprotein receptor FK536_RS19190 ENOG4105CPQ Dehydrogenase FK536_RS19200 ENOG410617M Transcriptional regulator FK536_RS19205 ENOG4105EEQ Na H antiporter FK536_RS19210 ENOG4108ERU trap dicarboxylate transporter subunit DctP FK536_RS19220 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FK536_RS19225 ENOG4105C8Q Methyl-accepting chemotaxis FK536_RS19230 ENOG4108V8F Transcriptional regulator, MarR family FK536_RS19235 ENOG4105ERH Fumarylacetoacetate hydrolase FK536_RS19240 ENOG4105C26 Dehydrogenase FK536_RS19245 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase FK536_RS19275 ENOG4105EFA 4-hydroxyphenylacetate FK536_RS19280 ENOG4107UWN reductase FK536_RS19285 ENOG4105D22 carbon starvation protein FK536_RS19290 ENOG4105VCD cytoplasmic protein FK536_RS19295 ENOG4105CKI cobalamin synthesis protein FK536_RS19340 ENOG4106DIZ Domain of unknown function (DUF1127) FK536_RS19345 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FK536_RS19355 ENOG41083G8 Multidrug resistance protein MdtM FK536_RS19360 ENOG4106BRA Membrane FK536_RS19365 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase FK536_RS19370 ENOG4105CIZ coA-substrate-specific enzyme activase FK536_RS19385 ENOG4105CBP Major Facilitator FK536_RS19395 ENOG41074DU domain protein FK536_RS19400 ENOG4108P2H Inner membrane protein YjiG FK536_RS19405 ENOG4105DYB Isoaspartyl dipeptidase FK536_RS19410 ENOG4107YNJ LysR family Transcriptional regulator FK536_RS19430 ENOG4105C6F GntR Family Transcriptional Regulator FK536_RS19435 ENOG4105DEI Mannitol dehydrogenase FK536_RS19450 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin FK536_RS19455 ENOG4108T65 Fimbrial FK536_RS19460 ENOG4108SQA Fimbrial FK536_RS19480 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria FK536_RS19485 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) FK536_RS19510 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 FK536_RS19550 ENOG4105DQ4 alcohol dehydrogenase FK536_RS19555 ENOG4105D7A ATP-binding protein FK536_RS19560 ENOG4108K5H permease YjgP YjgQ family protein FK536_RS19565 ENOG4108M8S permease YjgP YjgQ family protein FK536_RS19575 ENOG4105MYG DNA polymerase iii, chi subunit FK536_RS19585 ENOG4108M3P Membrane FK536_RS19590 ENOG4108MJ3 acetyltransferase FK536_RS19595 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) FK536_RS19610 ENOG4105XEP YhcH YjgK YiaL family protein FK536_RS19615 ENOG4108XFH Transcriptional regulator FK536_RS19620 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FK536_RS19625 ENOG4108UQ8 endoribonuclease L-psp FK536_RS19630 ENOG4107C93 pyrBI operon leader peptide FK536_RS19645 ENOG4105KME endoribonuclease L-psp FK536_RS19650 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FK536_RS19660 ENOG4105D4X repressor FK536_RS19665 ENOG4105C5Y PTS System FK536_RS19670 ENOG4105CG3 alpha amylase, catalytic region FK536_RS19675 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FK536_RS19680 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FK536_RS19690 ENOG4105CMS peptidase U62, modulator of DNA gyrase FK536_RS19700 ENOG4105DFU Cell wall formation (By similarity) FK536_RS19710 ENOG41062B0 ABC transporter, permease FK536_RS19715 ENOG4107R9N ABC transporter FK536_RS19720 ENOG4105C2J ABC transporter FK536_RS19725 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator FK536_RS19730 ENOG4105F0N pyrophosphate phospho-hydrolase FK536_RS19735 ENOG4108ZHD aig2 family FK536_RS19740 ENOG4105MA0 exported protein FK536_RS19745 ENOG4105CFU surface antigen FK536_RS19755 ENOG4105C37 (CBS) domain FK536_RS19760 ENOG41061GZ Protein of unknown function (DUF1107) FK536_RS19765 ENOG4108UUE Transcriptional regulator FK536_RS19770 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FK536_RS19780 ENOG4105KVH Transcriptional regulator FK536_RS19785 ENOG4105ECR NmrA family FK536_RS19790 ENOG4105DXC membrane FK536_RS19800 ENOG4105C85 amino acid FK536_RS19805 ENOG4108V1T peptidylprolyl cis-trans isomerase FK536_RS19810 ENOG4105FHY Opacity-associated protein A FK536_RS19820 ENOG4105CHR reductase FK536_RS19830 ENOG4105E39 Enoyl-CoA hydratase FK536_RS19835 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) FK536_RS19840 ENOG4107S3R L-aspartate oxidase FK536_RS19845 ENOG4105DPW Major facilitator superfamily MFS_1 FK536_RS19855 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FK536_RS19870 ENOG4105KIT UPF0379 protein yjfY FK536_RS19875 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FK536_RS19895 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport FK536_RS19900 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FK536_RS19915 ENOG4108MXZ Esterase FK536_RS19920 ENOG4105WSB biofilm stress and motility protein A FK536_RS19925 ENOG4105S17 UPF0379 protein yjfN FK536_RS19930 ENOG4105CSU acyl-Coa dehydrogenase FK536_RS19935 ENOG4106032 Glutathionylspermidine synthase FK536_RS19940 ENOG4108KXT Conserved Protein FK536_RS19945 ENOG4105Z6B inner membrane protein yjfl FK536_RS19950 ENOG4107VNS Protein of unknown function (DUF2491) FK536_RS19955 ENOG4108P9J Phage shock protein A FK536_RS19960 ENOG4105FUX Conserved Protein FK536_RS19965 ENOG4105C2N RNA methyltransferase TrmH family group 3 FK536_RS19970 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FK536_RS19990 ENOG4105EPW hflc protein FK536_RS19995 ENOG4107QJR hflk protein FK536_RS20000 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FK536_RS20015 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FK536_RS20020 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FK536_RS20025 ENOG4105K8N protein family UPF0079, ATPase FK536_RS20030 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FK536_RS20035 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FK536_RS20065 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FK536_RS20075 ENOG4105EGS Mechanosensitive ion channel FK536_RS20080 ENOG4107SC7 Inner membrane transporter yjeM FK536_RS20085 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FK536_RS20090 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FK536_RS20095 ENOG4105E33 succinate dehydrogenase FK536_RS20110 ENOG41066YJ Beta-lactamase FK536_RS20115 ENOG4105QNF Outer membrane lipoprotein FK536_RS20120 ENOG4105KPY Small multidrug resistance protein FK536_RS20125 ENOG4106BSU Entericidin B FK536_RS20130 ENOG4107PEH Entericidin EcnA/B family FK536_RS20140 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FK536_RS20145 ENOG4105MTB Uncharacterized protein YjeJ FK536_RS20150 ENOG4108ZVF (LipO)protein FK536_RS20165 ENOG4105DVH amino acid FK536_RS20170 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FK536_RS20175 ENOG4108IJ0 Aspartate ammonia-lyase FK536_RS20180 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FK536_RS20195 ENOG4108SIC Transcriptional regulator FK536_RS20205 ENOG4108M3R transcriptional activator CadC FK536_RS20210 ENOG4105D5Q Arginine ornithine antiporter FK536_RS20215 ENOG4105CXN decarboxylase FK536_RS20220 ENOG4105DUX Transporter FK536_RS20225 ENOG4105CRK lysyL-tRNA synthetase FK536_RS20240 ENOG410830R acetyltransferase FK536_RS20245 ENOG4105VR1 Pfam:DUF1271 FK536_RS20250 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FK536_RS20255 ENOG4108MRH transcriptional regulatory protein FK536_RS20260 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FK536_RS20265 ENOG4107GFK fumarate FK536_RS20270 ENOG4108R5S membrane FK536_RS20275 ENOG4105CT4 transporter FK536_RS20280 ENOG4105F8D glycoside hydrolase family 4 FK536_RS20285 ENOG4108K2B transcriptional regulator FK536_RS20290 ENOG4105CXN decarboxylase FK536_RS20295 ENOG4106ZGR Transcriptional regulator FK536_RS20300 ENOG4105D5Q Arginine ornithine antiporter FK536_RS20305 ENOG4105DIJ Phosphoethanolamine transferase FK536_RS20310 ENOG4105XJC Two component transcriptional regulator (Winged helix family FK536_RS20315 ENOG4105ECM Sensor protein basS pmrB FK536_RS20325 ENOG4105CSH Transporter FK536_RS20330 ENOG4108YIV FK536_RS20335 ENOG4108F5E vimentin FK536_RS20340 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FK536_RS20345 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase FK536_RS20350 ENOG4105D5T phosphonate abc transporter FK536_RS20355 ENOG4105EHI Phosphonate ABC transporter, periplasmic FK536_RS20365 ENOG4107RJJ Transcriptional regulator FK536_RS20370 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG FK536_RS20375 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH FK536_RS20380 ENOG4105EKV Phosphonate metabolism protein FK536_RS20385 ENOG4105FT8 Phosphonate metabolism FK536_RS20390 ENOG4105ENV phosphonate C-P lyase system protein PhnK FK536_RS20395 ENOG4105HRV phosphonate c-p lyase system protein phnl FK536_RS20400 ENOG4105FD8 phosphonate metabolism protein PhnM FK536_RS20405 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FK536_RS20410 ENOG410849A acetyltransferase, (GNAT) family FK536_RS20415 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein FK536_RS20425 ENOG4108YZG isomerase FK536_RS20430 ENOG4105NYY transcriptional regulator, RpiR FK536_RS20435 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FK536_RS20440 ENOG4105C2J ABC transporter FK536_RS20445 ENOG4105CNN ABC, transporter FK536_RS20450 ENOG4105UP7 3-epimerase FK536_RS20455 ENOG4107TFG D-allose kinase FK536_RS20460 ENOG4105EUZ Beta-lactamase domain protein FK536_RS20465 ENOG4106833 FK536_RS20470 ENOG4105J12 Multidrug resistance protein mdtN FK536_RS20480 ENOG4105ETP RND efflux system, outer membrane lipoprotein FK536_RS20490 ENOG41082ND Uncharacterized protein yjcO FK536_RS20495 ENOG4105CK2 sodium dicarboxylate symporter FK536_RS20500 ENOG4108W0S formate-dependent nitrite reductase complex FK536_RS20510 ENOG4108QKW cytochrome c-type biogenesis protein FK536_RS20515 ENOG4105DVI reductase, NrfD FK536_RS20520 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FK536_RS20525 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit FK536_RS20535 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FK536_RS20540 ENOG41062QD Membrane FK536_RS20555 ENOG4105EEQ Na H antiporter FK536_RS20560 ENOG4105C7N Xanthine uracil vitamin C permease FK536_RS20565 ENOG4108Z4X TRANSCRIPTIONal FK536_RS20570 ENOG4108W3Q Transcriptional regulator FK536_RS20580 ENOG4105PMV Membrane FK536_RS20585 ENOG4108UUM single-stranded DNA-binding protein FK536_RS20590 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FK536_RS20595 ENOG4105MSB protein, conserved in bacteria FK536_RS20600 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FK536_RS20605 ENOG4105F0S class B acid phosphatase FK536_RS20615 ENOG4105CGF Aromatic amino acid aminotransferase FK536_RS20620 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FK536_RS20625 ENOG4105CDU Replicative dna helicase FK536_RS20630 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FK536_RS20635 ENOG4105P4Z Phage shock protein G FK536_RS20640 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FK536_RS20650 ENOG4105MYN Zinc uptake regulation protein FK536_RS20655 ENOG4105VDW Csbd family FK536_RS20660 ENOG4107R73 Mate efflux family protein FK536_RS20670 ENOG41080IJ Diacylglycerol kinase FK536_RS20695 ENOG4107W52 maltose operon periplasmic protein FK536_RS20705 ENOG4108IJ9 (ABC) transporter FK536_RS20710 ENOG4107FKK extracellular solute-binding protein family 1 FK536_RS20715 ENOG4105D56 permease protein FK536_RS20720 ENOG4105EG2 ABC transporter, permease FK536_RS20725 ENOG4107QNK )-transporter FK536_RS20745 ENOG4105E3R (LipO)protein FK536_RS20750 ENOG4108Q9C Periplasmic Protein FK536_RS20755 ENOG4108MDC (LipO)protein FK536_RS20765 ENOG4107QP8 phosphohexose isomerase FK536_RS20770 ENOG4105CFH Aspartokinase FK536_RS20775 ENOG4108ZR5 Conserved Protein FK536_RS20780 ENOG4105FE9 pseudouridine synthase FK536_RS20785 ENOG4105DKT Transcriptional regulator FK536_RS20795 ENOG4105CHR reductase FK536_RS20800 ENOG4108XCU pts system FK536_RS20805 ENOG4105KPI PTS system sorbose subfamily IIB component FK536_RS20810 ENOG4105ETZ PTS System FK536_RS20815 ENOG4105F3R pts system mannose fructose sorbose family iid FK536_RS20820 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FK536_RS20830 ENOG4105EAM Na Pi-cotransporter FK536_RS20835 ENOG4105C3R Methionine synthase FK536_RS20840 ENOG41069M3 Transcriptional regulator FK536_RS20850 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) FK536_RS20855 ENOG4108I9X Isocitrate lyase FK536_RS20860 ENOG4107QP3 malate synthase g FK536_RS20870 ENOG4105K5X acetyltransferase FK536_RS20900 ENOG4105C12 Phosphoribosylglycinamide synthetase FK536_RS20905 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FK536_RS20910 ENOG4105BZU Histidine kinase FK536_RS20915 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism FK536_RS20920 ENOG4108T8B Protein of unknown function (DUF1481) FK536_RS20930 ENOG4105R2J Conserved Protein FK536_RS20965 ENOG4105D06 uba thif-type nad fad binding protein FK536_RS20970 ENOG4105WHD thiamine biosynthesis protein ThiS FK536_RS20975 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FK536_RS20980 ENOG4105D41 biosynthesis protein thiH FK536_RS20985 ENOG410645W Thiamin biosynthesis protein ThiH FK536_RS21020 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FK536_RS21025 ENOG4105PM1 preprotein translocase subunit SecE FK536_RS21060 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FK536_RS21065 ENOG4105D4A Cell wall formation (By similarity) FK536_RS21090 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FK536_RS21095 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FK536_RS21105 ENOG4108Y73 Membrane FK536_RS21110 ENOG4105EJ2 Transcriptional regulator FK536_RS21120 ENOG4105C5Q Transcriptional regulator FK536_RS21135 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FK536_RS21160 ENOG4105DIJ Phosphoethanolamine transferase FK536_RS21165 ENOG4106R3P AraC family transcriptional regulator FK536_RS21170 ENOG4108XCZ PTS System FK536_RS21175 ENOG4108AHH pyruvate formate lyase II activase FK536_RS21185 ENOG4108YRF PTS System FK536_RS21190 ENOG4105DM4 PTS System FK536_RS21195 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FK536_RS21200 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FK536_RS21205 ENOG4105DCT glycerol dehydrogenase FK536_RS21210 ENOG4108XC3 NADH ubiquinone oxidoreductase FK536_RS21215 ENOG4108Q5Y Membrane FK536_RS21225 ENOG4105SYT Methylenetetrahydrofolate reductase FK536_RS21230 ENOG4105CFH Aspartokinase FK536_RS21235 ENOG4105C28 cystathionine FK536_RS21245 ENOG4107S01 Repressor protein MetJ FK536_RS21260 ENOG4105CNA YD repeat protein FK536_RS21270 ENOG4105C25 Primosomal protein n' FK536_RS21275 ENOG4105ETE Transcriptional regulator (LacI family FK536_RS21280 ENOG41063M6 Cell Division Protein FK536_RS21295 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FK536_RS21310 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FK536_RS21320 ENOG4105CBT Fructose-1,6-bisphosphatase FK536_RS21325 ENOG4105DP0 ferredoxin-NADP reductase FK536_RS21335 ENOG41065TG regulatoR FK536_RS21340 ENOG4108VTS Membrane FK536_RS21345 ENOG4105EBK exported protein FK536_RS21360 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FK536_RS21375 ENOG4105FMW periplasmic FK536_RS21380 ENOG4105E3W Two component transcriptional regulator (Winged helix family FK536_RS21385 ENOG4105E0F Histidine kinase FK536_RS21390 ENOG4108RPX mosc domain containing protein FK536_RS21400 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FK536_RS21410 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) FK536_RS21440 ENOG41064BA PTS system, fructose-specific, IIA component FK536_RS21445 ENOG4105DM4 PTS System FK536_RS21450 ENOG4105CN9 Peptidase m42 family protein FK536_RS21455 ENOG4106C3V frv operon regulatory protein FK536_RS21460 ENOG4108V87 frv operon regulatory protein FK536_RS21465 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FK536_RS21475 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FK536_RS21480 ENOG4108MG3 formate dehydrogenase FK536_RS21490 ENOG41068KX affects formate dehydrogenase-N FK536_RS21505 ENOG4105SUU thioesterase domain FK536_RS21520 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 FK536_RS21525 ENOG4105E98 transcriptional regulator DeoR family FK536_RS21530 ENOG4108MGF sugar kinase FK536_RS21535 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FK536_RS21540 ENOG4105D2M Aldolase FK536_RS21560 ENOG4108K85 Transcriptional regulator FK536_RS21565 ENOG4105CI3 gtp-binding protein typa FK536_RS21570 ENOG4105C5F glutamine synthetase FK536_RS21575 ENOG4105CUX Signal transduction histidine kinase FK536_RS21580 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FK536_RS21585 ENOG4106FIY FK536_RS21590 ENOG4105D4P Coproporphyrinogen iii oxidase FK536_RS21605 ENOG4105C2M dna polymerase I FK536_RS21610 ENOG4106HNH Acyl-transferase FK536_RS21620 ENOG4108Z33 Thiol disulfide Interchange Protein FK536_RS21625 ENOG4105E27 serine threonine protein kinase FK536_RS21630 ENOG4105PC1 Conserved Protein FK536_RS21635 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FK536_RS21640 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FK536_RS21670 ENOG4108RR8 protoporphyrinogen oxidase FK536_RS21675 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FK536_RS21680 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FK536_RS21695 ENOG4105CHU acetyl-coa acetyltransferase FK536_RS21700 ENOG4108EX3 reductase FK536_RS21705 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FK536_RS21710 ENOG4105MDZ Transcriptional activator rfaH FK536_RS21715 ENOG4105F8V Hydrolase, tatD family FK536_RS21720 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FK536_RS21725 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FK536_RS21730 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FK536_RS21740 ENOG4105JC1 sterol-binding domain protein FK536_RS21750 ENOG4105CGY Dna recombination protein FK536_RS21755 ENOG4108I5U Uridine phosphorylase FK536_RS21760 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FK536_RS21770 ENOG4105DZ2 Transcriptional regulator FK536_RS21775 ENOG4105EMK carboxylate amino acid amine transporter FK536_RS21780 ENOG4105DQF Hydrolase FK536_RS21785 ENOG4108EUD Lysophospholipase FK536_RS21790 ENOG410829K Lysine exporter protein (Lyse ygga) FK536_RS21795 ENOG4105CCF Lysine exporter protein (Lyse ygga) FK536_RS21800 ENOG4105C9U ATP-dependent DNA helicase RecQ FK536_RS21805 ENOG4105HDD phospholipase FK536_RS21810 ENOG4108VUY thioesterase Superfamily protein FK536_RS21815 ENOG4105FR1 rard protein FK536_RS21820 ENOG4106WR8 Inner membrane protein YigG FK536_RS21825 ENOG4105NRM Membrane FK536_RS21830 ENOG4107QUT magnesium and cobalt transport protein CorA FK536_RS21835 ENOG4108T58 Mg2 transport protein CorA FK536_RS21840 ENOG4105C4R Atp-dependent dna helicase FK536_RS21845 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FK536_RS21855 ENOG4105CT0 Protein of unknown function, DUF484 FK536_RS21865 ENOG4105S7Z (LipO)protein FK536_RS21875 ENOG4107T0K Adenylate cyclase FK536_RS21880 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FK536_RS21885 ENOG41076E6 Uroporphyrinogen-III Synthase FK536_RS21890 ENOG4105ECF c-methyltransferase FK536_RS21895 ENOG410601J HemY protein FK536_RS21905 ENOG4105ENH Sulfatase FK536_RS21910 ENOG4105C4X radical SAM domain protein FK536_RS21935 ENOG4105C85 amino acid FK536_RS21940 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family FK536_RS21945 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) FK536_RS21950 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) FK536_RS21955 ENOG4105EGZ biosynthesis protein FK536_RS21960 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FK536_RS21965 ENOG4108WJ1 acetyltransferase FK536_RS21970 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FK536_RS21975 ENOG4105C1B dTDP-glucose 4-6-dehydratase FK536_RS21980 ENOG4107QQG Dehydrogenase FK536_RS21985 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FK536_RS21990 ENOG4105SFE lipopolysaccharide biosynthesis protein FK536_RS21995 ENOG4105ESV Glycosyl transferase, family 4 FK536_RS22000 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FK536_RS22025 ENOG4105C4R Atp-dependent dna helicase FK536_RS22035 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FK536_RS22045 ENOG4105EMY transcriptional regulator FK536_RS22050 ENOG4105C7B Threonine dehydratase FK536_RS22060 ENOG4105CM2 brancheD-chain amino acid aminotransferase FK536_RS22065 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FK536_RS22085 ENOG4105C0P Mg chelatase subunit ChlI FK536_RS22090 ENOG4105C0P Mg chelatase subunit ChlI FK536_RS22095 ENOG4108WFC UPF0438 protein yifE FK536_RS22135 ENOG4107EJG GntR family transcriptional regulator FK536_RS22140 ENOG4105C0R drug resistance transporter emrb qaca subfamily FK536_RS22145 ENOG4105ETE Transcriptional regulator (LacI family FK536_RS22150 ENOG4108RVA ribokinase FK536_RS22155 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FK536_RS22160 ENOG4105CNN ABC, transporter FK536_RS22165 ENOG4105C2J ABC transporter FK536_RS22170 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FK536_RS22185 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FK536_RS22195 ENOG4108VVK transcriptional Regulator, AsnC FK536_RS22200 ENOG4105QTB Flavodoxin FK536_RS22215 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation FK536_RS22265 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FK536_RS22270 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FK536_RS22275 ENOG4105C8U phosphate abc transporter FK536_RS22280 ENOG4105E2Z phosphate ABC transporter (Permease FK536_RS22285 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FK536_RS22290 ENOG4108UTW Plays a role in the regulation of phosphate uptake FK536_RS22295 ENOG4105CID antiterminator FK536_RS22300 ENOG4105C5Y PTS System FK536_RS22305 ENOG4105CS2 ec 3.2.1.21 FK536_RS22315 ENOG4105DYC esterase FK536_RS22320 ENOG4107VKM 6-phosphogluconolactonase FK536_RS22325 ENOG4106611 bacteriocin immunity FK536_RS22330 ENOG4106HGK Inner membrane protein yieI FK536_RS22335 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FK536_RS22340 ENOG4105C7N Xanthine uracil vitamin C permease FK536_RS22345 ENOG4108YYH Nadph-dependent fmn reductase FK536_RS22350 ENOG4105E8Q phosphopantetheinyl transferase FK536_RS22360 ENOG4105CNH Multidrug resistance protein MdtL FK536_RS22365 ENOG4108P6C Tryptophan transporter of low affinity FK536_RS22380 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FK536_RS22385 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FK536_RS22400 ENOG4105VG0 50S ribosomal protein l34 FK536_RS22420 ENOG4108QY5 Ferric enterobactin transport protein FK536_RS22495 ENOG4108BUD transposase FK536_RS22505 ENOG4108BUD transposase FK536_RS22520 ENOG4108BUD transposase FK536_RS22590 ENOG4108KTG Membrane protein, drug metabolite transporter FK536_RS22615 ENOG4108BUD transposase FK536_RS22655 ENOG4105C5H ABC transporter FK536_RS22695 ENOG4108BUD transposase FK536_RS22715 ENOG4108BUD transposase FK536_RS22745 ENOG4105EMU Dehydrogenase FK536_RS22755 ENOG4108BUD transposase FK536_RS22780 ENOG4108VSE mercuric transport protein FK536_RS22785 ENOG4105W1Y Transcriptional regulator FK536_RS22795 ENOG4108BUD transposase FK536_RS22820 ENOG4107QJE Chromosome Partitioning Protein FK536_RS22855 ENOG4105K4U addiction module toxin, RelE StbE family FK536_RS22905 ENOG410624V efflux system protein FK536_RS22945 ENOG4105BZU Histidine kinase FK536_RS22965 ENOG4105F9F transposase FK536_RS22985 ENOG4107QN2 dihydrolipoyl dehydrogenase FK536_RS22995 ENOG4108YXQ IS66 Orf2 family protein