locus-tag	class	description
FK536_RS00025	COG0592	DNA-directed DNA polymerase activity
FK536_RS00035	COG0187	DNA topoisomerase II activity
FK536_RS00040	COG3753	Protein conserved in bacteria
FK536_RS00045	COG0561	phosphatase activity
FK536_RS00055	COG2186	Transcriptional regulator
FK536_RS00060	COG3734	2-keto-3-deoxy-galactonokinase
FK536_RS00065	COG0800	Aldolase
FK536_RS00075	COG2271	Major facilitator Superfamily
FK536_RS00085	COG0823	Involved in the tonB-independent uptake of proteins
FK536_RS00090	COG5645	(Lipo)protein
FK536_RS00110	COG2188	Transcriptional regulator
FK536_RS00125	COG2207	Transcriptional regulator
FK536_RS00130	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK536_RS00135	COG3119	arylsulfatase activity
FK536_RS00145	COG2149	membrane
FK536_RS00155	COG0641	radical SAM
FK536_RS00160	COG2814	Major facilitator Superfamily
FK536_RS00175	COG0028	Belongs to the TPP enzyme family
FK536_RS00180	COG0440	acetolactate synthase activity
FK536_RS00185	COG2197	response regulator
FK536_RS00190	COG3851	Histidine kinase
FK536_RS00195	COG2271	Major facilitator Superfamily
FK536_RS00200	COG2271	Major facilitator Superfamily
FK536_RS00210	COG2252	PERMEase
FK536_RS00230	COG1464	Belongs to the NlpA lipoprotein family
FK536_RS00235	COG0697	spore germination
FK536_RS00240	COG2814	Major facilitator Superfamily
FK536_RS00255	COG2211	Major facilitator Superfamily
FK536_RS00260	COG1501	Belongs to the glycosyl hydrolase 31 family
FK536_RS00265	COG2982	Protein involved in outer membrane biogenesis
FK536_RS00270	COG2233	PERMEase
FK536_RS00275	COG0786	glutamate:sodium symporter activity
FK536_RS00280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FK536_RS00285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK536_RS00290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FK536_RS00300	COG0194	GDP metabolic process
FK536_RS00310	COG2860	membrane
FK536_RS00315	COG3645	SOS response
FK536_RS00400	COG1561	YicC-like family, N-terminal region
FK536_RS00420	COG0756	dUTP diphosphatase activity
FK536_RS00425	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FK536_RS00455	COG1519	Transferase
FK536_RS00460	COG0859	PFAM glycosyl transferase family 9
FK536_RS00465	COG0438	transferase activity, transferring glycosyl groups
FK536_RS00470	COG0515	serine threonine protein kinase
FK536_RS00475	COG4641	Protein conserved in bacteria
FK536_RS00475	COG0438	transferase activity, transferring glycosyl groups
FK536_RS00480	COG0438	transferase activity, transferring glycosyl groups
FK536_RS00485	COG1442	glycosyl transferase family 8
FK536_RS00490	COG1442	glycosyl transferase family 8
FK536_RS00495	COG3642	lipopolysaccharide core region biosynthetic process
FK536_RS00505	COG0859	PFAM glycosyl transferase family 9
FK536_RS00510	COG3307	-O-antigen
FK536_RS00515	COG0859	PFAM glycosyl transferase family 9
FK536_RS00520	COG0859	PFAM glycosyl transferase family 9
FK536_RS00535	COG0156	8-amino-7-oxononanoate synthase activity
FK536_RS00545	COG1216	Glycosyl transferase, family 2
FK536_RS00550	COG2861	carbohydrate metabolic process
FK536_RS00555	COG4942	peptidase
FK536_RS00560	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FK536_RS00565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FK536_RS00570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FK536_RS00585	COG1045	serine acetyltransferase
FK536_RS00590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FK536_RS00600	COG2186	Transcriptional regulator
FK536_RS00605	COG1620	l-lactate permease
FK536_RS00610	COG5295	Hep Hag repeat protein
FK536_RS00635	COG3722	fumarate hydratase activity
FK536_RS00645	COG2213	PTS system mannitol-specific
FK536_RS00645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS00655	COG1566	PFAM secretion protein HlyD family protein
FK536_RS00665	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FK536_RS00670	COG3209	COG3209 Rhs family protein
FK536_RS00675	COG1413	lyase activity
FK536_RS00680	COG3209	COG3209 Rhs family protein
FK536_RS00685	COG0625	glutathione transferase activity
FK536_RS00695	COG3276	selenocysteine insertion sequence binding
FK536_RS00700	COG1454	alcohol dehydrogenase
FK536_RS00705	COG1012	belongs to the aldehyde dehydrogenase family
FK536_RS00720	COG1566	PFAM secretion protein HlyD family protein
FK536_RS00725	COG0583	DNA-binding transcription factor activity
FK536_RS00730	COG3713	MltA-interacting MipA family protein
FK536_RS00740	COG2211	Major facilitator Superfamily
FK536_RS00750	COG0235	Class ii aldolase
FK536_RS00755	COG3623	hexulose-6-phosphate isomerase
FK536_RS00760	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FK536_RS00765	COG1070	Carbohydrate kinase
FK536_RS00770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FK536_RS00775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FK536_RS00780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FK536_RS00785	COG2731	YhcH YjgK YiaL family protein
FK536_RS00795	COG1414	Transcriptional regulator
FK536_RS00800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK536_RS00805	COG3977	Valine--pyruvate aminotransferase
FK536_RS00810	COG0366	Alpha amylase catalytic
FK536_RS00815	COG2992	FlgJ-related protein
FK536_RS00820	COG1609	Transcriptional regulator
FK536_RS00820	COG2207	Transcriptional regulator
FK536_RS00825	COG4214	carbohydrate transport
FK536_RS00830	COG1129	ABC transporter
FK536_RS00835	COG4213	ABC transporter substrate-binding protein
FK536_RS00845	COG1070	Carbohydrate kinase
FK536_RS00850	COG4682	membrane
FK536_RS00855	COG4682	membrane
FK536_RS00860	COG3274	enterobacterial common antigen metabolic process
FK536_RS00890	COG1278	Cold shock
FK536_RS00895	COG2944	sequence-specific DNA binding
FK536_RS00910	COG2885	chlorophyll binding
FK536_RS00915	COG0243	molybdopterin cofactor binding
FK536_RS00920	COG0456	acetyltransferase
FK536_RS00925	COG2818	Glycosylase
FK536_RS00930	COG5571	outer membrane autotransporter
FK536_RS00935	COG2223	nitrite transmembrane transporter activity
FK536_RS00940	COG2194	sulfuric ester hydrolase activity
FK536_RS00950	COG0747	negative chemotaxis
FK536_RS00955	COG0601	transmembrane transport
FK536_RS00960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FK536_RS00965	COG0444	Belongs to the ABC transporter superfamily
FK536_RS00970	COG4608	Belongs to the ABC transporter superfamily
FK536_RS00975	COG0814	amino acid
FK536_RS00985	COG2194	sulfuric ester hydrolase activity
FK536_RS01000	COG1215	transferase activity, transferring glycosyl groups
FK536_RS01005	COG1215	transferase activity, transferring glycosyl groups
FK536_RS01010	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
FK536_RS01015	COG0457	Tetratricopeptide repeat
FK536_RS01015	COG3118	belongs to the thioredoxin family
FK536_RS01020	COG2199	diguanylate cyclase activity
FK536_RS01020	COG2200	EAL domain
FK536_RS01030	COG0612	Peptidase, M16
FK536_RS01035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK536_RS01040	COG2200	EAL domain
FK536_RS01045	COG2982	Protein involved in outer membrane biogenesis
FK536_RS01050	COG0477	Major facilitator Superfamily
FK536_RS01055	COG1295	ribonuclease BN
FK536_RS01060	COG0583	DNA-binding transcription factor activity
FK536_RS01065	COG2197	response regulator
FK536_RS01075	COG1858	cytochrome C peroxidase
FK536_RS01080	COG0076	glutamate decarboxylase activity
FK536_RS01090	COG2207	Transcriptional regulator
FK536_RS01095	COG2207	Transcriptional regulator
FK536_RS01100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK536_RS01105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK536_RS01115	COG2771	luxR family
FK536_RS01120	COG3247	response to pH
FK536_RS01135	COG1285	pathogenesis
FK536_RS01140	COG2197	response regulator
FK536_RS01145	COG3065	identical protein binding
FK536_RS01155	COG1393	Belongs to the ArsC family
FK536_RS01160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FK536_RS01165	COG0640	Transcriptional regulator
FK536_RS01175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK536_RS01180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FK536_RS01185	COG0339	signal peptide processing
FK536_RS01195	COG3104	oligopeptide transport
FK536_RS01200	COG0589	response to stress
FK536_RS01210	COG0306	phosphate transporter
FK536_RS01215	COG2081	HI0933 family
FK536_RS01235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK536_RS01240	COG0842	Transport permease protein
FK536_RS01240	COG1129	ABC transporter
FK536_RS01245	COG0842	Transport permease protein
FK536_RS01250	COG5433	transposase activity
FK536_RS01255	COG1413	lyase activity
FK536_RS01265	COG3209	COG3209 Rhs family protein
FK536_RS01275	COG1124	(ABC) transporter
FK536_RS01280	COG0444	Belongs to the ABC transporter superfamily
FK536_RS01285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FK536_RS01290	COG0601	transmembrane transport
FK536_RS01295	COG0747	negative chemotaxis
FK536_RS01300	COG2091	lysine biosynthetic process via aminoadipic acid
FK536_RS01305	COG0628	permease
FK536_RS01310	COG0477	Major facilitator Superfamily
FK536_RS01320	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FK536_RS01330	COG2217	Heavy metal translocating P-type atpase
FK536_RS01335	COG3714	YhhN family
FK536_RS01345	COG3776	membrane
FK536_RS01350	COG0742	ribosomal rna small subunit methyltransferase
FK536_RS01355	COG0552	protein localization to endoplasmic reticulum
FK536_RS01360	COG2884	Cell division ATP-binding protein ftsE
FK536_RS01365	COG2177	Part of the ABC transporter FtsEX involved in
FK536_RS01370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FK536_RS01375	COG0683	leucine binding
FK536_RS01380	COG0456	acetyltransferase
FK536_RS01385	COG0683	leucine binding
FK536_RS01390	COG0559	Belongs to the binding-protein-dependent transport system permease family
FK536_RS01395	COG4177	L-phenylalanine transmembrane transporter activity
FK536_RS01400	COG0411	ABC transporter
FK536_RS01405	COG0410	ABC transporter
FK536_RS01410	COG1653	transport
FK536_RS01415	COG1175	transmembrane transport
FK536_RS01420	COG0395	ABC-type sugar transport system, permease component
FK536_RS01425	COG3842	ATPase activity
FK536_RS01430	COG0584	glycerophosphoryl diester phosphodiesterase
FK536_RS01440	COG0405	Gamma-glutamyltransferase
FK536_RS01460	COG1247	-acetyltransferase
FK536_RS01465	COG0673	inositol 2-dehydrogenase activity
FK536_RS01470	COG1741	Belongs to the pirin family
FK536_RS01475	COG1609	Transcriptional regulator
FK536_RS01480	COG3265	gluconokinase activity
FK536_RS01485	COG2610	gluconate transmembrane transporter activity
FK536_RS01490	COG2095	MarC family integral membrane protein
FK536_RS01495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FK536_RS01520	COG0058	SHG alpha-glucan phosphorylase activity
FK536_RS01530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FK536_RS01545	COG1349	DNA-binding transcription factor activity
FK536_RS01550	COG4650	regulator
FK536_RS01555	COG1690	Belongs to the RtcB family
FK536_RS01570	COG0058	SHG alpha-glucan phosphorylase activity
FK536_RS01575	COG1640	4-alpha-glucanotransferase
FK536_RS01580	COG2610	gluconate transmembrane transporter activity
FK536_RS01590	COG1040	competence protein
FK536_RS01600	COG5464	transposase or invertase
FK536_RS01610	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FK536_RS01615	COG1918	ferrous iron import across plasma membrane
FK536_RS01620	COG2183	response to ionizing radiation
FK536_RS01625	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK536_RS01630	COG0745	RESPONSE REGULATOR receiver
FK536_RS01635	COG2205	protein histidine kinase activity
FK536_RS01645	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FK536_RS01655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FK536_RS01660	COG1011	Hydrolase
FK536_RS01670	COG0494	nUDIX hydrolase
FK536_RS01675	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FK536_RS01680	COG4972	Pilus assembly protein
FK536_RS01685	COG3166	PFAM Fimbrial assembly family protein
FK536_RS01715	COG3266	domain, Protein
FK536_RS01720	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FK536_RS01725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FK536_RS01730	COG0546	phosphoglycolate phosphatase activity
FK536_RS01735	COG0180	Tryptophanyl-tRNA synthetase
FK536_RS01740	COG2188	Transcriptional regulator
FK536_RS01750	COG3457	Alanine racemase
FK536_RS01755	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FK536_RS01760	COG1735	metal-dependent hydrolase with the TIM-barrel fold
FK536_RS01775	COG0626	cystathionine gamma-synthase activity
FK536_RS01780	COG2188	Transcriptional regulator
FK536_RS01785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK536_RS01790	COG1082	Xylose isomerase domain protein TIM barrel
FK536_RS01795	COG2222	sugar isomerase
FK536_RS01800	COG0531	amino acid
FK536_RS01820	COG2116	formate transmembrane transporter activity
FK536_RS01825	COG2146	nitrite reductase [NAD(P)H] activity
FK536_RS01830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK536_RS01840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FK536_RS01850	COG2184	nucleotidyltransferase activity
FK536_RS01855	COG0512	Glutamine amidotransferase of anthranilate synthase
FK536_RS01860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FK536_RS01865	COG1289	transmembrane transporter activity
FK536_RS01870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FK536_RS01875	COG1765	OsmC-like protein
FK536_RS01880	COG3954	Phosphoribulokinase
FK536_RS01890	COG0429	hydrolase of the alpha beta-hydrolase fold
FK536_RS01895	COG0488	(ABC) transporter
FK536_RS01910	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
FK536_RS01915	COG1047	Peptidyl-prolyl cis-trans
FK536_RS01925	COG0545	Peptidyl-prolyl cis-trans isomerase
FK536_RS01930	COG2964	Protein conserved in bacteria
FK536_RS01970	COG3979	chitinase
FK536_RS01975	COG2906	2 iron, 2 sulfur cluster binding
FK536_RS01980	COG2193	ferroxidase activity
FK536_RS01985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FK536_RS01990	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FK536_RS01995	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FK536_RS02000	COG3156	type II secretion system protein K
FK536_RS02005	COG4795	General secretion pathway protein
FK536_RS02010	COG2165	general secretion pathway protein
FK536_RS02015	COG2165	general secretion pathway protein
FK536_RS02020	COG2165	general secretion pathway protein
FK536_RS02025	COG1459	type II secretion system
FK536_RS02030	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FK536_RS02035	COG1450	Type ii and iii secretion system protein
FK536_RS02040	COG3031	protein transport across the cell outer membrane
FK536_RS02045	COG3409	Peptidoglycan-binding domain 1 protein
FK536_RS02045	COG3267	Type II secretory pathway component ExeA
FK536_RS02070	COG0089	rRNA binding
FK536_RS02160	COG0201	protein transport
FK536_RS02200	COG0789	Transcriptional regulator
FK536_RS02205	COG3036	rescue of stalled ribosome
FK536_RS02215	COG0569	domain protein
FK536_RS02235	COG0758	DNA mediated transformation
FK536_RS02245	COG0551	DNA topoisomerase type I activity
FK536_RS02265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FK536_RS02310	COG1126	abc transporter atp-binding protein
FK536_RS02315	COG0765	amino acid transport
FK536_RS02320	COG4597	amino acid ABC transporter
FK536_RS02325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FK536_RS02340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK536_RS02345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK536_RS02350	COG1309	transcriptional regulator
FK536_RS02360	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FK536_RS02370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FK536_RS02380	COG4145	pantothenate transmembrane transporter activity
FK536_RS02385	COG3924	membrane
FK536_RS02390	COG0439	Biotin carboxylase
FK536_RS02395	COG0511	ligase activity, forming carbon-carbon bonds
FK536_RS02400	COG0604	alcohol dehydrogenase
FK536_RS02405	COG2200	EAL domain
FK536_RS02405	COG2199	diguanylate cyclase activity
FK536_RS02410	COG1077	Cell shape determining protein MreB Mrl
FK536_RS02415	COG1792	Involved in formation and maintenance of cell shape
FK536_RS02420	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FK536_RS02425	COG0424	maF-like protein
FK536_RS02430	COG1530	ribonuclease E activity
FK536_RS02435	COG3164	Protein of unknown function
FK536_RS02440	COG0312	modulator of DNA gyrase
FK536_RS02445	COG0583	DNA-binding transcription factor activity
FK536_RS02465	COG2732	(Barnase) inhibitor
FK536_RS02485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FK536_RS02490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FK536_RS02495	COG3105	Protein conserved in bacteria
FK536_RS02500	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FK536_RS02515	COG0625	glutathione transferase activity
FK536_RS02520	COG2969	positive regulation of protein catabolic process
FK536_RS02525	COG3069	C4-dicarboxylate transmembrane transporter activity
FK536_RS02555	COG2731	YhcH YjgK YiaL family protein
FK536_RS02560	COG4804	nuclease activity
FK536_RS02590	COG3188	usher protein
FK536_RS02595	COG3121	Chaperone
FK536_RS02600	COG3539	Fimbrial protein
FK536_RS02605	COG0493	'glutamate synthase
FK536_RS02610	COG0070	glutamate synthase
FK536_RS02610	COG0069	glutamate synthase activity
FK536_RS02610	COG0067	glutamate synthase
FK536_RS02615	COG1242	4 iron, 4 sulfur cluster binding
FK536_RS02620	COG2198	Histidine kinase
FK536_RS02620	COG5002	protein histidine kinase activity
FK536_RS02620	COG0784	Response regulator, receiver
FK536_RS02625	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FK536_RS02635	COG0515	serine threonine protein kinase
FK536_RS02640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS02655	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FK536_RS02660	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FK536_RS02665	COG1137	ATPase activity
FK536_RS02670	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FK536_RS02675	COG3117	lipopolysaccharide transmembrane transporter activity
FK536_RS02680	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FK536_RS02685	COG0517	IMP dehydrogenase activity
FK536_RS02685	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FK536_RS02690	COG0530	calcium, potassium:sodium antiporter activity
FK536_RS02695	COG1127	ABC transporter
FK536_RS02700	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FK536_RS02705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FK536_RS02710	COG2854	intermembrane phospholipid transfer
FK536_RS02715	COG3113	response to antibiotic
FK536_RS02720	COG5007	Belongs to the BolA IbaG family
FK536_RS02730	COG3423	Transcriptional regulator
FK536_RS02735	COG0142	geranyltranstransferase activity
FK536_RS02750	COG0697	spore germination
FK536_RS02760	COG2027	D-alanyl-D-alanine carboxypeptidase
FK536_RS02765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK536_RS02770	COG1534	Rna-binding protein
FK536_RS02780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FK536_RS02785	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FK536_RS02795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FK536_RS02810	COG2194	sulfuric ester hydrolase activity
FK536_RS02830	COG0195	Participates in both transcription termination and antitermination
FK536_RS02870	COG0513	Belongs to the DEAD box helicase family
FK536_RS02875	COG0814	amino acid
FK536_RS02880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FK536_RS02885	COG0826	peptidase U32
FK536_RS02890	COG0826	peptidase U32
FK536_RS02895	COG3154	lipid carrier protein
FK536_RS02900	COG3153	acetyltransferase
FK536_RS02915	COG0693	protein deglycase activity
FK536_RS02920	COG0702	epimerase
FK536_RS02925	COG0701	Predicted permease
FK536_RS02930	COG2823	Periplasmic or secreted lipoprotein
FK536_RS02945	COG3107	peptidoglycan biosynthetic process
FK536_RS02950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FK536_RS02955	COG3539	Fimbrial protein
FK536_RS02960	COG3188	usher protein
FK536_RS02965	COG3121	Chaperone
FK536_RS02970	COG3539	Fimbrial protein
FK536_RS02975	COG0363	glucosamine-6-phosphate deaminase activity
FK536_RS02980	COG3716	PTS system mannose fructose sorbose family IID component
FK536_RS02985	COG3715	PTS system
FK536_RS02990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FK536_RS03000	COG2222	sugar isomerase
FK536_RS03005	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FK536_RS03010	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS03015	COG3716	PTS system mannose fructose sorbose family IID component
FK536_RS03025	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FK536_RS03035	COG1349	DNA-binding transcription factor activity
FK536_RS03045	COG2002	toxin-antitoxin pair type II binding
FK536_RS03050	COG2721	sulfolactate sulfo-lyase activity
FK536_RS03055	COG2271	Major facilitator Superfamily
FK536_RS03065	COG2084	Dehydrogenase
FK536_RS03070	COG1929	Belongs to the glycerate kinase type-1 family
FK536_RS03095	COG0583	DNA-binding transcription factor activity
FK536_RS03100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FK536_RS03110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FK536_RS03115	COG1882	Formate acetyltransferase
FK536_RS03120	COG0251	oxidation-reduction process
FK536_RS03125	COG1760	l-serine dehydratase
FK536_RS03130	COG0814	amino acid
FK536_RS03145	COG1741	Belongs to the pirin family
FK536_RS03150	COG0583	DNA-binding transcription factor activity
FK536_RS03155	COG3152	Membrane
FK536_RS03160	COG3152	Membrane
FK536_RS03165	COG0435	Glutathione S-transferase
FK536_RS03170	COG2259	Doxx family
FK536_RS03180	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
FK536_RS03185	COG4575	ribosome binding
FK536_RS03190	COG1422	Protein of unknown function (DUF1090)
FK536_RS03200	COG0586	Pfam SNARE associated Golgi protein
FK536_RS03205	COG2186	Transcriptional regulator
FK536_RS03210	COG2271	Major facilitator Superfamily
FK536_RS03220	COG2721	sulfolactate sulfo-lyase activity
FK536_RS03230	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FK536_RS03235	COG0861	Integral membrane protein TerC family
FK536_RS03240	COG0673	inositol 2-dehydrogenase activity
FK536_RS03245	COG2949	membrane
FK536_RS03250	COG1451	nucleotide metabolic process
FK536_RS03260	COG4680	protein conserved in bacteria
FK536_RS03265	COG5499	transcription regulator containing HTH domain
FK536_RS03270	COG0446	pyridine nucleotide-disulphide oxidoreductase
FK536_RS03270	COG1902	pentaerythritol trinitrate reductase activity
FK536_RS03275	COG3408	Glycogen debranching enzyme
FK536_RS03275	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FK536_RS03285	COG0531	amino acid
FK536_RS03290	COG2731	YhcH YjgK YiaL family protein
FK536_RS03295	COG3250	beta-galactosidase activity
FK536_RS03300	COG1609	Transcriptional regulator
FK536_RS03305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK536_RS03315	COG0840	transmembrane signaling receptor activity
FK536_RS03320	COG1695	Transcriptional regulator
FK536_RS03325	COG2375	cellular response to nickel ion
FK536_RS03340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FK536_RS03345	COG0358	DNA primase activity
FK536_RS03350	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FK536_RS03360	COG0471	metal ion transport
FK536_RS03365	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FK536_RS03370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FK536_RS03385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FK536_RS03400	COG4991	sh3 domain protein
FK536_RS03405	COG3025	triphosphatase activity
FK536_RS03430	COG2268	Band 7 protein
FK536_RS03435	COG1585	Membrane protein implicated in regulation of membrane protease activity
FK536_RS03445	COG3539	Fimbrial protein
FK536_RS03450	COG3121	Chaperone
FK536_RS03455	COG3188	usher protein
FK536_RS03460	COG3539	Fimbrial protein
FK536_RS03465	COG2960	long-chain fatty acid transporting porin activity
FK536_RS03485	COG3384	dioxygenase
FK536_RS03490	COG0754	glutathionylspermidine amidase activity
FK536_RS03500	COG1538	Outer membrane efflux protein
FK536_RS03505	COG0494	nUDIX hydrolase
FK536_RS03510	COG3151	Protein conserved in bacteria
FK536_RS03515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FK536_RS03520	COG3150	esterase
FK536_RS03525	COG0187	DNA topoisomerase II activity
FK536_RS03530	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FK536_RS03535	COG2249	NAD(P)H dehydrogenase (quinone) activity
FK536_RS03545	COG0642	Histidine kinase
FK536_RS03550	COG0745	RESPONSE REGULATOR receiver
FK536_RS03555	COG3111	PFAM Bacterial OB fold (BOF) protein
FK536_RS03560	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
FK536_RS03570	COG2944	sequence-specific DNA binding
FK536_RS03575	COG4166	transmembrane transport
FK536_RS03580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FK536_RS03585	COG0204	Acyl-transferase
FK536_RS03590	COG2132	Multicopper oxidase
FK536_RS03595	COG1032	radical SAM domain protein
FK536_RS03600	COG4238	major outer membrane lipoprotein
FK536_RS03610	COG0656	L-ascorbic acid biosynthetic process
FK536_RS03615	COG1979	alcohol dehydrogenase
FK536_RS03620	COG2207	Transcriptional regulator
FK536_RS03625	COG0586	Pfam SNARE associated Golgi protein
FK536_RS03630	COG0626	cystathionine gamma-synthase activity
FK536_RS03635	COG0811	peptide transport
FK536_RS03640	COG0848	biopolymer transport protein
FK536_RS03645	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS03655	COG0667	Aldo Keto reductase
FK536_RS03670	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FK536_RS03675	COG0437	4 iron, 4 sulfur cluster binding
FK536_RS03680	COG5557	Pfam Polysulphide reductase, NrfD
FK536_RS03685	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FK536_RS03690	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FK536_RS03695	COG1773	rubredoxin
FK536_RS03705	COG0298	carbon dioxide binding
FK536_RS03710	COG0625	glutathione transferase activity
FK536_RS03715	COG0754	glutathionylspermidine amidase activity
FK536_RS03725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FK536_RS03730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FK536_RS03735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FK536_RS03740	COG2244	polysaccharide biosynthetic process
FK536_RS03750	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FK536_RS03755	COG0795	lipopolysaccharide-transporting ATPase activity
FK536_RS03765	COG0156	8-amino-7-oxononanoate synthase activity
FK536_RS03770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FK536_RS03780	COG0318	PFAM AMP-dependent synthetase and ligase
FK536_RS03785	COG0456	acetyltransferase
FK536_RS03790	COG2186	Transcriptional regulator
FK536_RS03795	COG0277	FAD linked oxidase domain protein
FK536_RS03800	COG0277	FAD linked oxidase domain protein
FK536_RS03805	COG0247	lactate metabolic process
FK536_RS03810	COG3193	protein, possibly involved in utilization of glycolate and propanediol
FK536_RS03815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FK536_RS03820	COG1620	l-lactate permease
FK536_RS03870	COG0531	amino acid
FK536_RS03885	COG1585	Membrane protein implicated in regulation of membrane protease activity
FK536_RS03895	COG3539	Fimbrial protein
FK536_RS03900	COG3121	Chaperone
FK536_RS03950	COG2378	regulation of single-species biofilm formation
FK536_RS03955	COG4735	regulation of single-species biofilm formation
FK536_RS03990	COG4974	Belongs to the 'phage' integrase family
FK536_RS04020	COG1811	Na channel or pump
FK536_RS04025	COG1982	Orn Lys Arg decarboxylase major
FK536_RS04030	COG2211	Major facilitator Superfamily
FK536_RS04045	COG1194	a g-specific adenine glycosylase
FK536_RS04055	COG3171	Protein conserved in bacteria
FK536_RS04065	COG0252	asparaginase activity
FK536_RS04075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK536_RS04090	COG0762	integral membrane protein
FK536_RS04095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FK536_RS04100	COG2805	Type II/IV secretion system protein
FK536_RS04115	COG0189	ligase activity
FK536_RS04120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FK536_RS04125	COG2356	endonuclease I
FK536_RS04135	COG2814	Major facilitator Superfamily
FK536_RS04160	COG1166	arginine decarboxylase activity
FK536_RS04170	COG0501	Belongs to the peptidase M48B family
FK536_RS04175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FK536_RS04180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS04185	COG2213	PTS system mannitol-specific
FK536_RS04190	COG1063	alcohol dehydrogenase
FK536_RS04195	COG1494	fructose-1,6-bisphosphatase
FK536_RS04200	COG3722	fumarate hydratase activity
FK536_RS04205	COG1072	(Pantothenic acid kinase))
FK536_RS04220	COG0191	fructose-bisphosphate aldolase activity
FK536_RS04225	COG0668	transmembrane transport
FK536_RS04230	COG1279	arginine transmembrane transporter activity
FK536_RS04235	COG2968	Membrane
FK536_RS04240	COG0583	DNA-binding transcription factor activity
FK536_RS04245	COG0427	acetyl-CoA hydrolase
FK536_RS04250	COG1024	Enoyl-CoA hydratase
FK536_RS04255	COG1703	isobutyryl-CoA mutase activity
FK536_RS04260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK536_RS04260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FK536_RS04280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FK536_RS04290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FK536_RS04310	COG0006	proline dipeptidase activity
FK536_RS04315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK536_RS04320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK536_RS04350	COG2723	6-phospho-beta-galactosidase activity
FK536_RS04360	COG1272	protein, Hemolysin III
FK536_RS04370	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FK536_RS04380	COG0716	FMN binding
FK536_RS04385	COG4974	Belongs to the 'phage' integrase family
FK536_RS04390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FK536_RS04395	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FK536_RS04405	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FK536_RS04425	COG2233	PERMEase
FK536_RS04435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK536_RS04440	COG2252	PERMEase
FK536_RS04445	COG0402	S-adenosylhomocysteine deaminase activity
FK536_RS04450	COG2233	PERMEase
FK536_RS04455	COG2080	2 iron, 2 sulfur cluster binding
FK536_RS04455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FK536_RS04460	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FK536_RS04465	COG0402	S-adenosylhomocysteine deaminase activity
FK536_RS04470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK536_RS04470	COG0493	'glutamate synthase
FK536_RS04475	COG2068	MobA-Related Protein
FK536_RS04480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FK536_RS04485	COG3608	succinylglutamate desuccinylase aspartoacylase
FK536_RS04485	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FK536_RS04490	COG0549	Belongs to the carbamate kinase family
FK536_RS04500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FK536_RS04505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FK536_RS04510	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FK536_RS04520	COG2080	2 iron, 2 sulfur cluster binding
FK536_RS04525	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FK536_RS04530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FK536_RS04535	COG4942	peptidase
FK536_RS04590	COG2771	luxR family
FK536_RS04595	COG0814	amino acid
FK536_RS04600	COG0183	Belongs to the thiolase family
FK536_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS04615	COG2814	Major facilitator Superfamily
FK536_RS04620	COG1794	racemase activity, acting on amino acids and derivatives
FK536_RS04625	COG0583	DNA-binding transcription factor activity
FK536_RS04635	COG1609	Transcriptional regulator
FK536_RS04650	COG0667	Aldo Keto reductase
FK536_RS04660	COG0861	Integral membrane protein TerC family
FK536_RS04675	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
FK536_RS04690	COG2165	general secretion pathway protein
FK536_RS04695	COG4795	General secretion pathway protein
FK536_RS04705	COG4967	type IV pilus modification protein PilV
FK536_RS04710	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FK536_RS04715	COG1025	Belongs to the peptidase M16 family
FK536_RS04720	COG1074	ATP-dependent DNA helicase activity
FK536_RS04725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FK536_RS04730	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FK536_RS04730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FK536_RS04735	COG0860	N-Acetylmuramoyl-L-alanine amidase
FK536_RS04755	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FK536_RS04760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FK536_RS04765	COG2166	iron-sulfur cluster assembly
FK536_RS04770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FK536_RS04780	COG0583	DNA-binding transcription factor activity
FK536_RS04785	COG2363	Small membrane protein
FK536_RS04795	COG1349	DNA-binding transcription factor activity
FK536_RS04805	COG1070	Carbohydrate kinase
FK536_RS04820	COG0235	Class ii aldolase
FK536_RS04825	COG1454	alcohol dehydrogenase
FK536_RS04835	COG1760	l-serine dehydratase
FK536_RS04840	COG0814	amino acid
FK536_RS04845	COG1611	Belongs to the LOG family
FK536_RS04860	COG3098	single-species biofilm formation
FK536_RS04865	COG0564	pseudouridine synthase activity
FK536_RS04870	COG0716	FMN binding
FK536_RS04875	COG2271	Major facilitator Superfamily
FK536_RS04880	COG4948	Mandelate Racemase Muconate Lactonizing
FK536_RS04885	COG4948	Mandelate Racemase Muconate Lactonizing
FK536_RS04890	COG4999	Histidine kinase
FK536_RS04890	COG3850	Histidine kinase
FK536_RS04890	COG3437	response regulator, receiver
FK536_RS04890	COG2205	protein histidine kinase activity
FK536_RS04900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FK536_RS04905	COG2336	PFAM SpoVT AbrB
FK536_RS04910	COG2337	Toxic component of a toxin-antitoxin (TA) module
FK536_RS04915	COG3956	TIGRFAM MazG family protein
FK536_RS04930	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FK536_RS04940	COG0602	queuosine metabolic process
FK536_RS04945	COG1070	Carbohydrate kinase
FK536_RS04950	COG2223	nitrite transmembrane transporter activity
FK536_RS04955	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS04960	COG0277	FAD linked oxidase domain protein
FK536_RS04965	COG0477	Major facilitator Superfamily
FK536_RS04970	COG2086	electron transfer activity
FK536_RS04975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FK536_RS04980	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FK536_RS04985	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FK536_RS04990	COG0644	oxidoreductase
FK536_RS04995	COG0720	synthase
FK536_RS05005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FK536_RS05020	COG3385	transposase activity
FK536_RS05030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK536_RS05035	COG2234	aminopeptidase activity
FK536_RS05090	COG4942	peptidase
FK536_RS05090	COG1388	LysM domain
FK536_RS05095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FK536_RS05100	COG2610	gluconate transmembrane transporter activity
FK536_RS05105	COG3622	Belongs to the hyi family
FK536_RS05110	COG0235	Class ii aldolase
FK536_RS05115	COG3395	kinase activity
FK536_RS05120	COG2084	Dehydrogenase
FK536_RS05125	COG1349	DNA-binding transcription factor activity
FK536_RS05130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FK536_RS05150	COG3604	Transcriptional regulator
FK536_RS05155	COG0309	Hydrogenase expression formation protein (HypE)
FK536_RS05160	COG0409	Hydrogenase expression formation protein
FK536_RS05165	COG0298	carbon dioxide binding
FK536_RS05170	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
FK536_RS05175	COG0375	protein maturation
FK536_RS05185	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK536_RS05190	COG0651	ATP synthesis coupled electron transport
FK536_RS05195	COG0650	Formate hydrogenlyase subunit 4
FK536_RS05200	COG3261	NADH dehydrogenase
FK536_RS05200	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
FK536_RS05205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK536_RS05210	COG3260	NADH ubiquinone oxidoreductase 20
FK536_RS05220	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FK536_RS05225	COG2723	6-phospho-beta-galactosidase activity
FK536_RS05230	COG1263	PTS System
FK536_RS05230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FK536_RS05235	COG1609	Transcriptional regulator
FK536_RS05240	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK536_RS05245	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FK536_RS05265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FK536_RS05265	COG0517	IMP dehydrogenase activity
FK536_RS05270	COG1349	DNA-binding transcription factor activity
FK536_RS05275	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS05280	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS05285	COG3731	PTS system glucitol sorbitol-specific IIA component
FK536_RS05290	COG3732	PTS system glucitol sorbitol-specific
FK536_RS05295	COG3730	PTS system glucitol sorbitol-specific
FK536_RS05300	COG2951	lytic endotransglycosylase activity
FK536_RS05305	COG1546	Belongs to the CinA family
FK536_RS05325	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
FK536_RS05355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK536_RS05360	COG1238	metal cluster binding
FK536_RS05375	COG2814	Major facilitator Superfamily
FK536_RS05380	COG1566	PFAM secretion protein HlyD family protein
FK536_RS05385	COG1846	Transcriptional regulator
FK536_RS05400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FK536_RS05405	COG2814	Major facilitator Superfamily
FK536_RS05410	COG2113	Glycine betaine
FK536_RS05415	COG4176	ABC-type proline glycine betaine transport system permease component
FK536_RS05420	COG4175	Glycine betaine
FK536_RS05425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FK536_RS05430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FK536_RS05440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FK536_RS05445	COG4575	ribosome binding
FK536_RS05460	COG2916	Histone family protein nucleoid-structuring protein H-NS
FK536_RS05465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FK536_RS05470	COG0640	Transcriptional regulator
FK536_RS05475	COG0401	homolog of Blt101
FK536_RS05480	COG1652	LysM domain
FK536_RS05485	COG1802	Transcriptional regulator
FK536_RS05490	COG1113	amino acid transport
FK536_RS05495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FK536_RS05500	COG1012	belongs to the aldehyde dehydrogenase family
FK536_RS05505	COG0579	oxidoreductase
FK536_RS05520	COG0366	Alpha amylase catalytic
FK536_RS05545	COG3468	outer membrane autotransporter barrel domain protein
FK536_RS05595	COG1475	DNA binding
FK536_RS05610	COG0582	viral genome integration into host DNA
FK536_RS05625	COG2867	negative regulation of translational initiation
FK536_RS05635	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK536_RS05640	COG0497	DNA recombination
FK536_RS05655	COG4536	flavin adenine dinucleotide binding
FK536_RS05660	COG4137	Cytochrome C assembly protein
FK536_RS05665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FK536_RS05690	COG2885	chlorophyll binding
FK536_RS05695	COG2199	diguanylate cyclase activity
FK536_RS05710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FK536_RS05715	COG1605	Chorismate mutase
FK536_RS05715	COG0287	Prephenate dehydrogenase
FK536_RS05720	COG1605	Chorismate mutase
FK536_RS05720	COG0077	Prephenate dehydratase
FK536_RS05730	COG4974	Belongs to the 'phage' integrase family
FK536_RS05775	COG4695	Portal protein
FK536_RS05875	COG5301	cellulose 1,4-beta-cellobiosidase activity
FK536_RS05880	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FK536_RS05905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FK536_RS05910	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK536_RS05915	COG0564	pseudouridine synthase activity
FK536_RS05925	COG0542	response to heat
FK536_RS05950	COG0477	Major facilitator Superfamily
FK536_RS05955	COG5544	Lipoprotein
FK536_RS05960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FK536_RS05965	COG1042	CoA-binding domain protein
FK536_RS05965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FK536_RS05965	COG0045	succinate-CoA ligase (ADP-forming) activity
FK536_RS05975	COG3118	belongs to the thioredoxin family
FK536_RS05980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK536_RS06000	COG0583	DNA-binding transcription factor activity
FK536_RS06005	COG0513	Belongs to the DEAD box helicase family
FK536_RS06015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FK536_RS06025	COG1595	DNA-templated transcription, initiation
FK536_RS06030	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
FK536_RS06035	COG3026	antisigma factor binding
FK536_RS06040	COG3086	response to oxidative stress
FK536_RS06050	COG0681	Belongs to the peptidase S26 family
FK536_RS06070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FK536_RS06085	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK536_RS06090	COG1737	Transcriptional regulator
FK536_RS06095	COG0560	Phosphoserine phosphatase
FK536_RS06115	COG2205	protein histidine kinase activity
FK536_RS06120	COG3170	Tfp pilus assembly protein FimV
FK536_RS06125	COG2204	response regulator
FK536_RS06130	COG0347	Belongs to the P(II) protein family
FK536_RS06135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FK536_RS06135	COG1017	nitric oxide dioxygenase activity
FK536_RS06145	COG1940	carbohydrate kinase activity
FK536_RS06150	COG0457	Tetratricopeptide repeat
FK536_RS06155	COG1879	ABC-type sugar transport system periplasmic component
FK536_RS06160	COG1129	ABC transporter
FK536_RS06165	COG1172	Belongs to the binding-protein-dependent transport system permease family
FK536_RS06170	COG1063	alcohol dehydrogenase
FK536_RS06175	COG2017	converts alpha-aldose to the beta-anomer
FK536_RS06180	COG2259	Doxx family
FK536_RS06205	COG4638	Rieske (2fe-2S)
FK536_RS06210	COG0583	DNA-binding transcription factor activity
FK536_RS06215	COG2814	Major facilitator Superfamily
FK536_RS06220	COG3711	transcriptional antiterminator
FK536_RS06225	COG1073	alpha beta
FK536_RS06230	COG0483	inositol monophosphate 1-phosphatase activity
FK536_RS06250	COG0822	iron-sulfur transferase activity
FK536_RS06270	COG0633	Ferredoxin
FK536_RS06275	COG2975	iron-sulfur cluster assembly
FK536_RS06290	COG2897	thiosulfate sulfurtransferase activity
FK536_RS06295	COG2373	Large extracellular alpha-helical protein
FK536_RS06300	COG4953	penicillin-binding protein 1C
FK536_RS06330	COG2976	Protein conserved in bacteria
FK536_RS06345	COG1645	bacterial-type flagellum-dependent swarming motility
FK536_RS06355	COG0516	GMP reductase activity
FK536_RS06355	COG0517	IMP dehydrogenase activity
FK536_RS06370	COG3133	Outer membrane lipoprotein
FK536_RS06395	COG0248	Ppx GppA phosphatase
FK536_RS06400	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FK536_RS06405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FK536_RS06420	COG2233	PERMEase
FK536_RS06430	COG1393	Belongs to the ArsC family
FK536_RS06435	COG4783	chaperone-mediated protein folding
FK536_RS06440	COG0628	permease
FK536_RS06445	COG2116	formate transmembrane transporter activity
FK536_RS06450	COG3604	Transcriptional regulator
FK536_RS06460	COG3260	NADH ubiquinone oxidoreductase 20
FK536_RS06465	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK536_RS06470	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
FK536_RS06470	COG3261	NADH dehydrogenase
FK536_RS06475	COG0651	ATP synthesis coupled electron transport
FK536_RS06480	COG4237	Hydrogenase 4 membrane
FK536_RS06485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK536_RS06490	COG0650	Formate hydrogenlyase subunit 4
FK536_RS06500	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK536_RS06505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FK536_RS06510	COG2716	regulation of RNA biosynthetic process
FK536_RS06520	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
FK536_RS06530	COG2321	neutral zinc metallopeptidase
FK536_RS06535	COG1444	tRNA N-acetyltransferase activity
FK536_RS06540	COG0400	carboxylic ester hydrolase activity
FK536_RS06555	COG1393	Belongs to the ArsC family
FK536_RS06565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK536_RS06570	COG3850	Histidine kinase
FK536_RS06575	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK536_RS06575	COG0493	'glutamate synthase
FK536_RS06585	COG5342	invasion associated locus B
FK536_RS06590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FK536_RS06595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FK536_RS06600	COG0280	phosphate acetyltransferase
FK536_RS06600	COG0281	malic enzyme
FK536_RS06605	COG4810	utilization protein
FK536_RS06610	COG4917	ethanolamine utilization protein
FK536_RS06615	COG4766	ethanolamine catabolic process
FK536_RS06620	COG4812	Cobalamin adenosyltransferase
FK536_RS06625	COG0280	phosphate acetyltransferase
FK536_RS06630	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FK536_RS06635	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
FK536_RS06640	COG1012	belongs to the aldehyde dehydrogenase family
FK536_RS06645	COG4820	ethanolamine utilization protein (EutJ)
FK536_RS06650	COG1454	alcohol dehydrogenase
FK536_RS06655	COG3192	ethanolamine utilization protein
FK536_RS06660	COG4819	ethanolamine utilization protein
FK536_RS06665	COG4303	Ethanolamine ammonia lyase large subunit
FK536_RS06675	COG4816	utilization protein
FK536_RS06680	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FK536_RS06685	COG2207	Transcriptional regulator
FK536_RS06695	COG0860	N-Acetylmuramoyl-L-alanine amidase
FK536_RS06700	COG0456	acetyltransferase
FK536_RS06715	COG2837	iron assimilation
FK536_RS06720	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FK536_RS06725	COG1263	PTS System
FK536_RS06725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FK536_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS06745	COG4150	thiosulfate binding
FK536_RS06750	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FK536_RS06755	COG4208	sulfate ABC transporter
FK536_RS06760	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FK536_RS06765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FK536_RS06770	COG4884	unkown
FK536_RS06770	COG3831	ATPase activity
FK536_RS06785	COG2190	(PTS) system
FK536_RS06790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FK536_RS06795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS06800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FK536_RS06820	COG3530	Putative quorum-sensing-regulated virulence factor
FK536_RS06825	COG0385	Bile acid
FK536_RS06830	COG0583	DNA-binding transcription factor activity
FK536_RS06840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FK536_RS06845	COG2211	Major facilitator Superfamily
FK536_RS06855	COG0583	DNA-binding transcription factor activity
FK536_RS06890	COG3415	Transposase
FK536_RS06895	COG3415	Transposase
FK536_RS06910	COG2200	EAL domain
FK536_RS06910	COG2199	diguanylate cyclase activity
FK536_RS06915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FK536_RS06940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS06945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS06950	COG0006	proline dipeptidase activity
FK536_RS06955	COG1363	Peptidase, m42
FK536_RS06960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS06960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FK536_RS06960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS06965	COG2207	Transcriptional regulator
FK536_RS06970	COG3279	Response regulator of the LytR AlgR family
FK536_RS06975	COG3275	phosphorelay sensor kinase activity
FK536_RS06980	COG0436	Aminotransferase
FK536_RS06990	COG1560	Kdo2-lipid A biosynthetic process
FK536_RS07015	COG0028	Belongs to the TPP enzyme family
FK536_RS07020	COG0679	Auxin Efflux Carrier
FK536_RS07025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FK536_RS07030	COG2205	protein histidine kinase activity
FK536_RS07030	COG0784	Response regulator, receiver
FK536_RS07030	COG2198	Histidine kinase
FK536_RS07030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FK536_RS07035	COG2197	response regulator
FK536_RS07040	COG1566	PFAM secretion protein HlyD family protein
FK536_RS07045	COG0477	Major facilitator Superfamily
FK536_RS07055	COG2610	gluconate transmembrane transporter activity
FK536_RS07110	COG3299	homolog of phage Mu protein gp47
FK536_RS07115	COG3778	Protein conserved in bacteria
FK536_RS07145	COG0582	viral genome integration into host DNA
FK536_RS07155	COG2116	formate transmembrane transporter activity
FK536_RS07160	COG2853	Lipoprotein
FK536_RS07170	COG2067	long-chain fatty acid transport protein
FK536_RS07175	COG3691	Protein conserved in bacteria
FK536_RS07190	COG2062	phosphohistidine phosphatase, SixA
FK536_RS07195	COG3539	Fimbrial protein
FK536_RS07200	COG3188	usher protein
FK536_RS07205	COG3121	Chaperone
FK536_RS07210	COG3539	Fimbrial protein
FK536_RS07215	COG3539	Fimbrial protein
FK536_RS07220	COG3539	Fimbrial protein
FK536_RS07235	COG2890	protein-(glutamine-N5) methyltransferase activity
FK536_RS07250	COG0730	response to heat
FK536_RS07255	COG3101	peptidyl-lysine hydroxylation
FK536_RS07270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK536_RS07275	COG2814	Major facilitator Superfamily
FK536_RS07290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FK536_RS07300	COG0586	Pfam SNARE associated Golgi protein
FK536_RS07310	COG0285	dihydrofolate synthase activity
FK536_RS07315	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FK536_RS07320	COG1286	toxin biosynthetic process
FK536_RS07325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FK536_RS07330	COG0163	prenyltransferase activity
FK536_RS07335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FK536_RS07340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FK536_RS07345	COG4215	(ABC) transporter
FK536_RS07350	COG4160	amino acid transport
FK536_RS07355	COG4598	ABC transporter
FK536_RS07360	COG5464	transposase or invertase
FK536_RS07365	COG1090	epimerase
FK536_RS07370	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FK536_RS07375	COG0625	glutathione transferase activity
FK536_RS07380	COG0625	glutathione transferase activity
FK536_RS07385	COG0622	Phosphoesterase
FK536_RS07390	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FK536_RS07395	COG1288	antiporter activity
FK536_RS07400	COG0280	phosphate acetyltransferase
FK536_RS07400	COG0857	belongs to the CobB CobQ family
FK536_RS07405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FK536_RS07420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK536_RS07425	COG0471	metal ion transport
FK536_RS07425	COG0490	domain, Protein
FK536_RS07435	COG0436	Aminotransferase
FK536_RS07440	COG0583	DNA-binding transcription factor activity
FK536_RS07460	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
FK536_RS07465	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FK536_RS07470	COG1034	ATP synthesis coupled electron transport
FK536_RS07485	COG0839	Belongs to the complex I subunit 6 family
FK536_RS07495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FK536_RS07500	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK536_RS07530	COG2153	protein acetylation
FK536_RS07535	COG4575	ribosome binding
FK536_RS07540	COG1169	isochorismate synthase
FK536_RS07555	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FK536_RS07565	COG0318	PFAM AMP-dependent synthetase and ligase
FK536_RS07630	COG1414	Transcriptional regulator
FK536_RS07640	COG2271	Major facilitator Superfamily
FK536_RS07655	COG5464	transposase or invertase
FK536_RS07660	COG0247	lactate metabolic process
FK536_RS07670	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FK536_RS07675	COG2271	Major facilitator Superfamily
FK536_RS07680	COG0584	glycerophosphoryl diester phosphodiesterase
FK536_RS07690	COG3642	lipopolysaccharide core region biosynthetic process
FK536_RS07695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FK536_RS07700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FK536_RS07705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FK536_RS07710	COG3468	outer membrane autotransporter barrel domain protein
FK536_RS07720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FK536_RS07725	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
FK536_RS07730	COG3234	Protein of unknown function (DUF1175)
FK536_RS07740	COG5445	Predicted secreted protein (DUF2300)
FK536_RS07745	COG4676	Protein conserved in bacteria
FK536_RS07750	COG0183	Belongs to the thiolase family
FK536_RS07755	COG2031	fatty acid transporter
FK536_RS07760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
FK536_RS07765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FK536_RS07770	COG2204	response regulator
FK536_RS07775	COG3852	Histidine kinase
FK536_RS07780	COG0784	Response regulator, receiver
FK536_RS07780	COG2205	protein histidine kinase activity
FK536_RS07785	COG2197	response regulator
FK536_RS07790	COG2198	Histidine kinase
FK536_RS07790	COG0642	Histidine kinase
FK536_RS07795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FK536_RS07800	COG1477	protein flavinylation
FK536_RS07805	COG2169	Transcriptional regulator
FK536_RS07805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FK536_RS07810	COG3145	DNA-N1-methyladenine dioxygenase activity
FK536_RS07815	COG4615	Cyclic peptide transporter
FK536_RS07835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK536_RS07835	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
FK536_RS07840	COG3062	negative regulation of establishment of protein localization
FK536_RS07850	COG0437	4 iron, 4 sulfur cluster binding
FK536_RS07855	COG0348	domain, Protein
FK536_RS07860	COG3043	anaerobic respiration
FK536_RS07865	COG3005	denitrification pathway
FK536_RS07870	COG4133	protoheme IX ABC transporter activity
FK536_RS07875	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FK536_RS07880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FK536_RS07885	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FK536_RS07895	COG1138	Cytochrome C-type biogenesis protein
FK536_RS07900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FK536_RS07905	COG3088	subunit of a heme lyase
FK536_RS07905	COG4235	cytochrome complex assembly
FK536_RS07910	COG2197	response regulator
FK536_RS07915	COG3468	outer membrane autotransporter barrel domain protein
FK536_RS07925	COG3083	sulfuric ester hydrolase activity
FK536_RS07945	COG1061	Type III restriction enzyme res subunit
FK536_RS07950	COG1187	pseudouridine synthase activity
FK536_RS07955	COG2814	Major facilitator Superfamily
FK536_RS07965	COG4172	Belongs to the ABC transporter superfamily
FK536_RS07970	COG4239	(ABC) transporter, permease
FK536_RS07975	COG4174	ABC transporter (Permease)
FK536_RS07980	COG4166	transmembrane transport
FK536_RS07985	COG2200	EAL domain
FK536_RS07990	COG0791	NLP P60 protein
FK536_RS07995	COG0671	phosphoesterase, PA-phosphatase related
FK536_RS08000	COG0523	cobalamin synthesis protein
FK536_RS08005	COG0246	Mannitol dehydrogenase
FK536_RS08020	COG2814	Major facilitator Superfamily
FK536_RS08025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS08025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS08030	COG1105	Belongs to the carbohydrate kinase PfkB family
FK536_RS08035	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FK536_RS08035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS08035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS08040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK536_RS08045	COG2313	pseudouridylate synthase activity
FK536_RS08050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FK536_RS08055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FK536_RS08065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FK536_RS08070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK536_RS08070	COG1522	sequence-specific DNA binding
FK536_RS08080	COG2855	membrane
FK536_RS08085	COG0583	DNA-binding transcription factor activity
FK536_RS08090	COG0833	amino acid
FK536_RS08095	COG4771	TonB-dependent receptor
FK536_RS08110	COG2311	Membrane
FK536_RS08115	COG1609	Transcriptional regulator
FK536_RS08120	COG1879	ABC-type sugar transport system periplasmic component
FK536_RS08125	COG1129	ABC transporter
FK536_RS08130	COG4211	Belongs to the binding-protein-dependent transport system permease family
FK536_RS08135	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FK536_RS08135	COG0167	dihydroorotate dehydrogenase activity
FK536_RS08140	COG0493	'glutamate synthase
FK536_RS08150	COG2949	membrane
FK536_RS08160	COG1346	cytolysis
FK536_RS08170	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FK536_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS08190	COG0586	Pfam SNARE associated Golgi protein
FK536_RS08200	COG1686	Belongs to the peptidase S11 family
FK536_RS08205	COG0277	FAD linked oxidase domain protein
FK536_RS08210	COG1472	Belongs to the glycosyl hydrolase 3 family
FK536_RS08215	COG1732	Glycine betaine
FK536_RS08220	COG1174	glycine betaine transport
FK536_RS08225	COG1125	glycine betaine transport
FK536_RS08230	COG1174	glycine betaine transport
FK536_RS08240	COG0789	Transcriptional regulator
FK536_RS08245	COG3275	phosphorelay sensor kinase activity
FK536_RS08250	COG3279	Response regulator of the LytR AlgR family
FK536_RS08255	COG4807	Protein conserved in bacteria
FK536_RS08260	COG4808	Protein conserved in bacteria
FK536_RS08265	COG4715	Zinc finger, swim domain protein
FK536_RS08270	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FK536_RS08275	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FK536_RS08280	COG0714	Associated with various cellular activities
FK536_RS08295	COG3831	ATPase activity
FK536_RS08305	COG0489	protein tyrosine kinase activity
FK536_RS08315	COG3539	Fimbrial protein
FK536_RS08320	COG3121	Chaperone
FK536_RS08325	COG3188	usher protein
FK536_RS08330	COG3539	Fimbrial protein
FK536_RS08335	COG5455	response to cobalt ion
FK536_RS08355	COG0351	phosphomethylpyrimidine kinase
FK536_RS08360	COG3757	hydrolase, family 25
FK536_RS08365	COG2188	Transcriptional regulator
FK536_RS08370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK536_RS08375	COG1397	ADP-ribosylglycohydrolase
FK536_RS08380	COG2211	Major facilitator Superfamily
FK536_RS08385	COG1830	Aldolase
FK536_RS08405	COG3414	Phosphotransferase system galactitol-specific IIB component
FK536_RS08410	COG3775	system Galactitol-specific IIC component
FK536_RS08415	COG1063	alcohol dehydrogenase
FK536_RS08445	COG3609	addiction module antidote protein, CC2985 family
FK536_RS08455	COG0745	RESPONSE REGULATOR receiver
FK536_RS08460	COG2205	protein histidine kinase activity
FK536_RS08500	COG4245	von Willebrand factor, type A
FK536_RS08505	COG0631	protein serine/threonine phosphatase activity
FK536_RS08510	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
FK536_RS08515	COG0443	Heat shock 70 kDa protein
FK536_RS08520	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
FK536_RS08525	COG5002	protein histidine kinase activity
FK536_RS08525	COG3447	MASE1 domain protein
FK536_RS08525	COG5001	Diguanylate cyclase
FK536_RS08530	COG0572	uridine kinase
FK536_RS08540	COG2982	Protein involved in outer membrane biogenesis
FK536_RS08545	COG1253	flavin adenine dinucleotide binding
FK536_RS08550	COG1596	polysaccharide export
FK536_RS08555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FK536_RS08560	COG3206	protein involved in exopolysaccharide biosynthesis
FK536_RS08560	COG0489	protein tyrosine kinase activity
FK536_RS08565	COG0463	Glycosyl transferase, family 2
FK536_RS08570	COG1045	serine acetyltransferase
FK536_RS08575	COG0438	transferase activity, transferring glycosyl groups
FK536_RS08585	COG1216	Glycosyl transferase, family 2
FK536_RS08590	COG0110	maltose O-acetyltransferase activity
FK536_RS08595	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FK536_RS08600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK536_RS08605	COG1051	belongs to the nudix hydrolase family
FK536_RS08610	COG0297	glycogen (starch) synthase activity
FK536_RS08615	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FK536_RS08615	COG0662	Cupin 2, conserved barrel domain protein
FK536_RS08620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FK536_RS08625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FK536_RS08630	COG2244	polysaccharide biosynthetic process
FK536_RS08635	COG2327	Polysaccharide pyruvyl transferase
FK536_RS08640	COG0438	transferase activity, transferring glycosyl groups
FK536_RS08650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK536_RS08655	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FK536_RS08660	COG1088	dTDP-glucose 4,6-dehydratase activity
FK536_RS08665	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FK536_RS08710	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FK536_RS08715	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FK536_RS08720	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
FK536_RS08725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FK536_RS08725	COG0140	phosphoribosyl-ATP diphosphatase activity
FK536_RS08740	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FK536_RS08745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FK536_RS08745	COG0131	Imidazoleglycerol-phosphate dehydratase
FK536_RS08755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FK536_RS08770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK536_RS08775	COG0583	DNA-binding transcription factor activity
FK536_RS08785	COG0531	amino acid
FK536_RS08790	COG2391	methyltransferase activity
FK536_RS08795	COG0425	Belongs to the sulfur carrier protein TusA family
FK536_RS08800	COG2925	Exonuclease
FK536_RS08805	COG1686	Belongs to the peptidase S11 family
FK536_RS08815	COG1289	transmembrane transporter activity
FK536_RS08860	COG2003	Belongs to the UPF0758 family
FK536_RS08915	COG1735	metal-dependent hydrolase with the TIM-barrel fold
FK536_RS08930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK536_RS08950	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
FK536_RS08965	COG1376	ErfK ybiS ycfS ynhG family protein
FK536_RS08975	COG0583	DNA-binding transcription factor activity
FK536_RS08980	COG0583	DNA-binding transcription factor activity
FK536_RS08990	COG0534	Mate efflux family protein
FK536_RS09000	COG0217	transcriptional regulatory protein
FK536_RS09005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FK536_RS09010	COG0477	Major facilitator Superfamily
FK536_RS09045	COG3038	cytochrome b561
FK536_RS09050	COG3443	Belongs to the bacterial solute-binding protein 9 family
FK536_RS09065	COG2351	hydroxyisourate hydrolase activity
FK536_RS09070	COG0745	RESPONSE REGULATOR receiver
FK536_RS09075	COG2205	protein histidine kinase activity
FK536_RS09085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FK536_RS09095	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FK536_RS09105	COG1418	mRNA catabolic process
FK536_RS09110	COG0270	DNA (cytosine-5-)-methyltransferase activity
FK536_RS09115	COG3727	T/G mismatch-specific endonuclease activity
FK536_RS09120	COG0697	spore germination
FK536_RS09125	COG2354	Protein conserved in bacteria
FK536_RS09130	COG5475	Uncharacterized small protein (DUF2158)
FK536_RS09155	COG2197	response regulator
FK536_RS09160	COG1684	flagellar biosynthetic protein fliR
FK536_RS09165	COG1987	bacterial-type flagellum assembly
FK536_RS09170	COG1338	Plays a role in the flagellum-specific transport system
FK536_RS09175	COG3190	flagellar
FK536_RS09180	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FK536_RS09185	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FK536_RS09190	COG1580	Controls the rotational direction of flagella during chemotaxis
FK536_RS09195	COG3144	bacterial-type flagellum assembly
FK536_RS09200	COG2882	bacterial-type flagellum organization
FK536_RS09205	COG1157	protein secretion by the type III secretion system
FK536_RS09210	COG1317	bacterial-type flagellum organization
FK536_RS09215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FK536_RS09220	COG1766	The M ring may be actively involved in energy transduction
FK536_RS09230	COG2135	peptidase activity
FK536_RS09235	COG0425	Belongs to the sulfur carrier protein TusA family
FK536_RS09240	COG2391	methyltransferase activity
FK536_RS09250	COG0366	Alpha amylase catalytic
FK536_RS09260	COG1516	flagellar protein fliS
FK536_RS09265	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FK536_RS09275	COG1191	sigma factor activity
FK536_RS09305	COG2197	response regulator
FK536_RS09320	COG2197	response regulator
FK536_RS09395	COG1183	phosphatidylcholine synthase activity
FK536_RS09400	COG2194	sulfuric ester hydrolase activity
FK536_RS09420	COG3012	SEC-C Motif Domain Protein
FK536_RS09420	COG3318	Belongs to the UPF0149 family
FK536_RS09425	COG0814	amino acid
FK536_RS09435	COG1528	Iron-storage protein
FK536_RS09455	COG1528	Iron-storage protein
FK536_RS09460	COG1879	ABC-type sugar transport system periplasmic component
FK536_RS09465	COG1129	ABC transporter
FK536_RS09470	COG1172	Belongs to the binding-protein-dependent transport system permease family
FK536_RS09475	COG1877	trehalose-phosphatase activity
FK536_RS09485	COG0589	response to stress
FK536_RS09500	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FK536_RS09505	COG1360	Flagellar Motor Protein
FK536_RS09510	COG0643	Histidine kinase
FK536_RS09510	COG2198	Histidine kinase
FK536_RS09515	COG0835	chemotaxis
FK536_RS09520	COG0840	transmembrane signaling receptor activity
FK536_RS09525	COG0840	transmembrane signaling receptor activity
FK536_RS09530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FK536_RS09535	COG2201	protein-glutamate methylesterase activity
FK536_RS09540	COG0745	RESPONSE REGULATOR receiver
FK536_RS09545	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FK536_RS09550	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FK536_RS09555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FK536_RS09565	COG3755	Protein conserved in bacteria
FK536_RS09575	COG3102	Protein conserved in bacteria
FK536_RS09585	COG3005	denitrification pathway
FK536_RS09590	COG0243	molybdopterin cofactor binding
FK536_RS09605	COG3788	relative of glutathione S-transferase, MAPEG superfamily
FK536_RS09610	COG1801	Protein of unknown function DUF72
FK536_RS09615	COG1335	isochorismatase
FK536_RS09625	COG0494	nUDIX hydrolase
FK536_RS09630	COG0217	transcriptional regulatory protein
FK536_RS09660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FK536_RS09670	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FK536_RS09675	COG0739	heme binding
FK536_RS09680	COG1560	Kdo2-lipid A biosynthetic process
FK536_RS09685	COG0469	pyruvate kinase activity
FK536_RS09690	COG1737	Transcriptional regulator
FK536_RS09695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FK536_RS09700	COG0129	dihydroxy-acid dehydratase activity
FK536_RS09705	COG0800	Aldolase
FK536_RS09715	COG3141	response to X-ray
FK536_RS09725	COG2979	Protein of unknown function (DUF533)
FK536_RS09730	COG1770	oligopeptidase
FK536_RS09735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK536_RS09740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK536_RS09750	COG2372	response to copper ion
FK536_RS09755	COG1276	copper resistance
FK536_RS09765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FK536_RS09785	COG3008	intermembrane lipid transfer
FK536_RS09790	COG2995	paraquat-inducible protein a
FK536_RS09795	COG1956	GAF domain-containing protein
FK536_RS09805	COG0793	Belongs to the peptidase S41A family
FK536_RS09815	COG2814	Major facilitator Superfamily
FK536_RS09820	COG1414	Transcriptional regulator
FK536_RS09850	COG2226	methyltransferase
FK536_RS09865	COG3716	PTS system mannose fructose sorbose family IID component
FK536_RS09870	COG3715	PTS system
FK536_RS09875	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS09875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FK536_RS09880	COG1253	flavin adenine dinucleotide binding
FK536_RS09885	COG2200	EAL domain
FK536_RS09890	COG1760	l-serine dehydratase
FK536_RS09900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FK536_RS09915	COG0251	oxidation-reduction process
FK536_RS09920	COG1199	ATP-dependent helicase activity
FK536_RS09925	COG1214	PFAM Peptidase M22, glycoprotease
FK536_RS09930	COG3065	identical protein binding
FK536_RS09935	COG0318	PFAM AMP-dependent synthetase and ligase
FK536_RS09940	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FK536_RS09945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FK536_RS09950	COG4638	Rieske (2fe-2S)
FK536_RS09960	COG0473	3-isopropylmalate dehydrogenase activity
FK536_RS09965	COG0583	DNA-binding transcription factor activity
FK536_RS09975	COG3615	Tellurite resistance protein tehB
FK536_RS09985	COG2261	transglycosylase associated protein
FK536_RS10000	COG2199	diguanylate cyclase activity
FK536_RS10000	COG2203	Gaf domain
FK536_RS10005	COG3042	response to heat
FK536_RS10010	COG3189	MarR family transcriptional regulator
FK536_RS10015	COG2807	transmembrane transport
FK536_RS10020	COG2207	Transcriptional regulator
FK536_RS10035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FK536_RS10040	COG2199	diguanylate cyclase activity
FK536_RS10045	COG2199	diguanylate cyclase activity
FK536_RS10055	COG2766	serine protein kinase
FK536_RS10060	COG3713	MltA-interacting MipA family protein
FK536_RS10065	COG0656	L-ascorbic acid biosynthetic process
FK536_RS10070	COG0676	glucose-6-phosphate 1-epimerase activity
FK536_RS10075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FK536_RS10085	COG3139	Protein of unknown function (DUF1315)
FK536_RS10095	COG2271	Major facilitator Superfamily
FK536_RS10100	COG1063	alcohol dehydrogenase
FK536_RS10105	COG0191	fructose-bisphosphate aldolase activity
FK536_RS10110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK536_RS10115	COG0667	Aldo Keto reductase
FK536_RS10120	COG1349	DNA-binding transcription factor activity
FK536_RS10135	COG1335	isochorismatase
FK536_RS10140	COG0252	asparaginase activity
FK536_RS10145	COG0616	signal peptide processing
FK536_RS10150	COG0778	Nitroreductase
FK536_RS10160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FK536_RS10170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FK536_RS10180	COG0494	nUDIX hydrolase
FK536_RS10185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FK536_RS10190	COG2897	thiosulfate sulfurtransferase activity
FK536_RS10195	COG4136	ATPase activity
FK536_RS10200	COG4135	transport system, permease component
FK536_RS10205	COG4134	Bacterial extracellular solute-binding protein
FK536_RS10210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FK536_RS10215	COG0398	Pfam SNARE associated Golgi protein
FK536_RS10225	COG0398	Pfam SNARE associated Golgi protein
FK536_RS10230	COG0708	Exodeoxyribonuclease III
FK536_RS10265	COG3678	ATP-independent chaperone mediated protein folding
FK536_RS10275	COG0322	excinuclease ABC activity
FK536_RS10285	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK536_RS10290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FK536_RS10295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FK536_RS10300	COG1447	Phosphotransferase system cellobiose-specific component IIA
FK536_RS10305	COG2169	Transcriptional regulator
FK536_RS10305	COG1917	Cupin 2, conserved barrel domain protein
FK536_RS10310	COG1486	melibiose metabolic process
FK536_RS10320	COG0753	catalase activity
FK536_RS10350	COG1988	membrane-bound metal-dependent
FK536_RS10355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK536_RS10365	COG3001	Fructosamine kinase
FK536_RS10375	COG1105	Belongs to the carbohydrate kinase PfkB family
FK536_RS10380	COG3137	Salt-induced outer membrane protein
FK536_RS10425	COG0072	phenylalanine-tRNA ligase activity
FK536_RS10425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FK536_RS10440	COG0386	Belongs to the glutathione peroxidase family
FK536_RS10450	COG0791	NLP P60 protein
FK536_RS10455	COG2200	EAL domain
FK536_RS10465	COG4256	Hemin uptake protein
FK536_RS10470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FK536_RS10480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FK536_RS10480	COG0574	Belongs to the PEP-utilizing enzyme family
FK536_RS10485	COG0318	PFAM AMP-dependent synthetase and ligase
FK536_RS10490	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FK536_RS10495	COG0644	oxidoreductase
FK536_RS10500	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FK536_RS10505	COG2086	electron transfer activity
FK536_RS10510	COG1917	Cupin 2, conserved barrel domain protein
FK536_RS10510	COG2207	Transcriptional regulator
FK536_RS10515	COG1960	acyl-CoA dehydrogenase activity
FK536_RS10520	COG4670	ketone body catabolic process
FK536_RS10535	COG2271	Major facilitator Superfamily
FK536_RS10540	COG0738	Major facilitator superfamily
FK536_RS10555	COG0628	permease
FK536_RS10560	COG0277	FAD linked oxidase domain protein
FK536_RS10560	COG0247	lactate metabolic process
FK536_RS10565	COG2050	protein possibly involved in aromatic compounds catabolism
FK536_RS10575	COG0316	Belongs to the HesB IscA family
FK536_RS10580	COG0719	Fe-S assembly protein
FK536_RS10585	COG0396	ATPase activity
FK536_RS10590	COG0719	Fe-S assembly protein
FK536_RS10605	COG1376	ErfK ybiS ycfS ynhG family protein
FK536_RS10610	COG4238	major outer membrane lipoprotein
FK536_RS10615	COG0469	pyruvate kinase activity
FK536_RS10625	COG0437	4 iron, 4 sulfur cluster binding
FK536_RS10630	COG2414	aldehyde ferredoxin oxidoreductase
FK536_RS10640	COG0437	4 iron, 4 sulfur cluster binding
FK536_RS10645	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
FK536_RS10655	COG4529	Protein conserved in bacteria
FK536_RS10675	COG3468	outer membrane autotransporter barrel domain protein
FK536_RS10685	COG0307	riboflavin synthase, alpha
FK536_RS10690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FK536_RS10695	COG2814	Major facilitator Superfamily
FK536_RS10700	COG0583	DNA-binding transcription factor activity
FK536_RS10715	COG2814	Major facilitator Superfamily
FK536_RS10720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FK536_RS10725	COG0791	NLP P60 protein
FK536_RS10735	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FK536_RS10740	COG1201	RNA secondary structure unwinding
FK536_RS10745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK536_RS10750	COG0346	lactoylglutathione lyase activity
FK536_RS10755	COG1902	pentaerythritol trinitrate reductase activity
FK536_RS10760	COG1309	transcriptional regulator
FK536_RS10765	COG3313	Fe-S protein
FK536_RS10770	COG4989	oxidoreductase activity
FK536_RS10775	COG2032	superoxide dismutase activity
FK536_RS10780	COG1289	transmembrane transporter activity
FK536_RS10785	COG1566	PFAM secretion protein HlyD family protein
FK536_RS10800	COG3133	Outer membrane lipoprotein
FK536_RS10810	COG3895	Periplasmic Protein
FK536_RS10825	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FK536_RS10830	COG0625	glutathione transferase activity
FK536_RS10835	COG3104	oligopeptide transport
FK536_RS10840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FK536_RS10850	COG4659	FMN binding
FK536_RS10890	COG0673	inositol 2-dehydrogenase activity
FK536_RS10900	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FK536_RS10905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FK536_RS10905	COG1263	PTS System
FK536_RS10910	COG1609	Transcriptional regulator
FK536_RS10915	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS10920	COG1309	transcriptional regulator
FK536_RS10925	COG3250	beta-galactosidase activity
FK536_RS10940	COG5339	Protein conserved in bacteria
FK536_RS10945	COG1482	cell wall glycoprotein biosynthetic process
FK536_RS10950	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FK536_RS10950	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FK536_RS10955	COG0114	fumarate hydratase activity
FK536_RS10965	COG2205	protein histidine kinase activity
FK536_RS10970	COG0745	RESPONSE REGULATOR receiver
FK536_RS10975	COG3136	membrane protein required for alginate biosynthesis
FK536_RS10985	COG0531	amino acid
FK536_RS10995	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FK536_RS11000	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FK536_RS11005	COG0628	permease
FK536_RS11020	COG3591	Belongs to the peptidase S1B family
FK536_RS11035	COG2814	Major facilitator Superfamily
FK536_RS11040	COG0583	DNA-binding transcription factor activity
FK536_RS11045	COG1940	carbohydrate kinase activity
FK536_RS11050	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FK536_RS11060	COG3381	protein complex oligomerization
FK536_RS11065	COG3302	dmso reductase anchor subunit
FK536_RS11070	COG0437	4 iron, 4 sulfur cluster binding
FK536_RS11075	COG0243	molybdopterin cofactor binding
FK536_RS11080	COG0243	molybdopterin cofactor binding
FK536_RS11095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FK536_RS11110	COG4948	Mandelate Racemase Muconate Lactonizing
FK536_RS11115	COG1063	alcohol dehydrogenase
FK536_RS11125	COG0582	viral genome integration into host DNA
FK536_RS11135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK536_RS11160	COG0246	Mannitol dehydrogenase
FK536_RS11170	COG1802	Transcriptional regulator
FK536_RS11175	COG4221	oxidoreductase activity
FK536_RS11180	COG0339	signal peptide processing
FK536_RS11185	COG1546	Belongs to the CinA family
FK536_RS11195	COG3111	PFAM Bacterial OB fold (BOF) protein
FK536_RS11200	COG3706	GGDEF domain
FK536_RS11210	COG2814	Major facilitator Superfamily
FK536_RS11215	COG0697	spore germination
FK536_RS11225	COG4977	sequence-specific DNA binding
FK536_RS11230	COG1846	Transcriptional regulator
FK536_RS11250	COG0583	DNA-binding transcription factor activity
FK536_RS11255	COG1012	belongs to the aldehyde dehydrogenase family
FK536_RS11260	COG2066	Belongs to the glutaminase family
FK536_RS11270	COG2199	diguanylate cyclase activity
FK536_RS11280	COG3781	membrane
FK536_RS11330	COG3210	domain, Protein
FK536_RS11330	COG2911	Protein conserved in bacteria
FK536_RS11335	COG1396	sequence-specific DNA binding
FK536_RS11340	COG3550	peptidyl-serine autophosphorylation
FK536_RS11395	COG3539	Fimbrial protein
FK536_RS11400	COG3539	Fimbrial protein
FK536_RS11405	COG3539	Fimbrial protein
FK536_RS11410	COG0243	molybdopterin cofactor binding
FK536_RS11425	COG3119	arylsulfatase activity
FK536_RS11430	COG0641	radical SAM
FK536_RS11440	COG4178	(ABC) transporter
FK536_RS11445	COG4771	TonB-dependent receptor
FK536_RS11450	COG0612	Peptidase, M16
FK536_RS11455	COG0076	glutamate decarboxylase activity
FK536_RS11460	COG0531	amino acid
FK536_RS11470	COG3706	GGDEF domain
FK536_RS11475	COG2202	Pas domain
FK536_RS11475	COG2200	EAL domain
FK536_RS11475	COG2199	diguanylate cyclase activity
FK536_RS11480	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FK536_RS11485	COG0747	negative chemotaxis
FK536_RS11490	COG0601	transmembrane transport
FK536_RS11495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FK536_RS11500	COG0444	Belongs to the ABC transporter superfamily
FK536_RS11505	COG4608	Belongs to the ABC transporter superfamily
FK536_RS11510	COG1764	response to oxidative stress
FK536_RS11530	COG1064	alcohol dehydrogenase
FK536_RS11535	COG3093	addiction module antidote protein HigA
FK536_RS11540	COG2864	formate dehydrogenase
FK536_RS11545	COG0437	4 iron, 4 sulfur cluster binding
FK536_RS11555	COG0697	spore germination
FK536_RS11560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FK536_RS11570	COG2223	nitrite transmembrane transporter activity
FK536_RS11575	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FK536_RS11580	COG1140	nitrate reductase beta subunit
FK536_RS11585	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FK536_RS11590	COG2181	nitrate reductase activity
FK536_RS11595	COG0384	phenazine biosynthesis protein PhzF
FK536_RS11600	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FK536_RS11605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK536_RS11615	COG5433	transposase activity
FK536_RS11635	COG3209	COG3209 Rhs family protein
FK536_RS11645	COG0625	glutathione transferase activity
FK536_RS11650	COG1113	amino acid transport
FK536_RS11655	COG3391	amine dehydrogenase activity
FK536_RS11660	COG4772	TonB-dependent receptor
FK536_RS11665	COG1802	Transcriptional regulator
FK536_RS11670	COG2130	NADP-dependent
FK536_RS11675	COG1247	-acetyltransferase
FK536_RS11680	COG3238	Protein conserved in bacteria
FK536_RS11705	COG1177	transmembrane transport
FK536_RS11710	COG1176	ABC-type spermidine putrescine transport system, permease component I
FK536_RS11715	COG3842	ATPase activity
FK536_RS11720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FK536_RS11725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FK536_RS11730	COG1598	PFAM Uncharacterised protein family UPF0150
FK536_RS11735	COG1724	mRNA binding
FK536_RS11745	COG0826	peptidase U32
FK536_RS11750	COG1396	sequence-specific DNA binding
FK536_RS11755	COG3135	benzoate transporter
FK536_RS11760	COG0675	Transposase, IS605 OrfB family
FK536_RS11775	COG0500	methyltransferase
FK536_RS11780	COG1275	C4-dicarboxylate transporter malic acid transport protein
FK536_RS11785	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FK536_RS11790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FK536_RS11795	COG2841	Protein conserved in bacteria
FK536_RS11805	COG5383	Protein conserved in bacteria
FK536_RS11810	COG0583	DNA-binding transcription factor activity
FK536_RS11815	COG0840	transmembrane signaling receptor activity
FK536_RS11835	COG3038	cytochrome b561
FK536_RS11845	COG1012	belongs to the aldehyde dehydrogenase family
FK536_RS11850	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FK536_RS11860	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FK536_RS11865	COG1643	Atp-dependent helicase
FK536_RS11880	COG2267	carboxylic ester hydrolase activity
FK536_RS11885	COG4589	Belongs to the CDS family
FK536_RS11890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FK536_RS11900	COG0667	Aldo Keto reductase
FK536_RS11915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FK536_RS11920	COG3327	negative regulation of DNA-templated transcription, initiation
FK536_RS11925	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FK536_RS11930	COG0183	Belongs to the thiolase family
FK536_RS11935	COG2050	protein possibly involved in aromatic compounds catabolism
FK536_RS11940	COG1250	3-hydroxyacyl-CoA dehydrogenase
FK536_RS11945	COG1024	Enoyl-CoA hydratase
FK536_RS11950	COG1024	Enoyl-CoA hydratase
FK536_RS11955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FK536_RS11960	COG2151	metal-sulfur cluster biosynthetic enzyme
FK536_RS11965	COG3396	Phenylacetate-CoA oxygenase
FK536_RS11970	COG3460	Phenylacetate-CoA oxygenase
FK536_RS11975	COG3396	Phenylacetate-CoA oxygenase
FK536_RS11980	COG2030	dehydratase
FK536_RS11980	COG1012	belongs to the aldehyde dehydrogenase family
FK536_RS11985	COG3733	amine oxidase
FK536_RS11990	COG1012	belongs to the aldehyde dehydrogenase family
FK536_RS11995	COG2207	Transcriptional regulator
FK536_RS12000	COG3784	Protein of unknown function (DUF1318)
FK536_RS12010	COG2911	Protein conserved in bacteria
FK536_RS12015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FK536_RS12020	COG3187	Heat shock protein
FK536_RS12025	COG3042	response to heat
FK536_RS12030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FK536_RS12030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FK536_RS12030	COG1013	pyruvate-flavodoxin oxidoreductase activity
FK536_RS12030	COG0674	pyruvate-flavodoxin oxidoreductase activity
FK536_RS12035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FK536_RS12040	COG0589	response to stress
FK536_RS12050	COG0513	Belongs to the DEAD box helicase family
FK536_RS12060	COG3706	GGDEF domain
FK536_RS12065	COG2840	Smr protein MutS2
FK536_RS12070	COG0583	DNA-binding transcription factor activity
FK536_RS12075	COG1473	amidohydrolase
FK536_RS12080	COG1473	amidohydrolase
FK536_RS12085	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FK536_RS12090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FK536_RS12095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FK536_RS12100	COG0589	response to stress
FK536_RS12105	COG3182	Iron-regulated membrane protein
FK536_RS12110	COG0668	transmembrane transport
FK536_RS12115	COG4166	transmembrane transport
FK536_RS12125	COG1073	alpha beta
FK536_RS12140	COG2866	Carboxypeptidase
FK536_RS12145	COG4948	Mandelate Racemase Muconate Lactonizing
FK536_RS12150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FK536_RS12155	COG3283	Transcriptional regulator of aromatic amino acids metabolism
FK536_RS12165	COG3106	COG3106 Predicted ATPase
FK536_RS12170	COG1609	Transcriptional regulator
FK536_RS12180	COG3842	ATPase activity
FK536_RS12185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK536_RS12190	COG1554	hydrolase, family 65, central catalytic
FK536_RS12195	COG0673	inositol 2-dehydrogenase activity
FK536_RS12200	COG1082	Xylose isomerase domain protein TIM barrel
FK536_RS12205	COG1063	alcohol dehydrogenase
FK536_RS12210	COG0395	ABC-type sugar transport system, permease component
FK536_RS12215	COG1175	transmembrane transport
FK536_RS12220	COG1653	transport
FK536_RS12225	COG0366	Alpha amylase catalytic
FK536_RS12230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FK536_RS12240	COG1983	PspC domain protein
FK536_RS12250	COG1842	Phage shock protein A
FK536_RS12255	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FK536_RS12260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FK536_RS12265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FK536_RS12270	COG1012	belongs to the aldehyde dehydrogenase family
FK536_RS12275	COG1396	sequence-specific DNA binding
FK536_RS12275	COG1917	Cupin 2, conserved barrel domain protein
FK536_RS12280	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FK536_RS12285	COG0174	glutamine synthetase
FK536_RS12295	COG0531	amino acid
FK536_RS12305	COG4166	transmembrane transport
FK536_RS12310	COG4168	peptide transport system, permease
FK536_RS12315	COG4171	peptide transport system, permease
FK536_RS12320	COG4172	Belongs to the ABC transporter superfamily
FK536_RS12325	COG4172	Belongs to the ABC transporter superfamily
FK536_RS12330	COG2852	Protein conserved in bacteria
FK536_RS12335	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FK536_RS12340	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FK536_RS12340	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FK536_RS12355	COG5001	Diguanylate cyclase
FK536_RS12365	COG1349	DNA-binding transcription factor activity
FK536_RS12375	COG0023	Translation Initiation Factor
FK536_RS12385	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FK536_RS12390	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FK536_RS12395	COG0671	phosphoesterase, PA-phosphatase related
FK536_RS12405	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FK536_RS12425	COG0583	DNA-binding transcription factor activity
FK536_RS12430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FK536_RS12440	COG0616	signal peptide processing
FK536_RS12445	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS12450	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FK536_RS12455	COG1187	pseudouridine synthase activity
FK536_RS12460	COG4907	membrane protein (DUF2207)
FK536_RS12465	COG0009	L-threonylcarbamoyladenylate synthase
FK536_RS12470	COG0613	PHP domain protein
FK536_RS12480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FK536_RS12485	COG0512	Glutamine amidotransferase of anthranilate synthase
FK536_RS12485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FK536_RS12490	COG0135	phosphoribosylanthranilate isomerase activity
FK536_RS12490	COG0134	indole-3-glycerol-phosphate synthase activity
FK536_RS12505	COG3729	General stress protein
FK536_RS12510	COG3685	Protein conserved in bacteria
FK536_RS12515	COG3685	Protein conserved in bacteria
FK536_RS12520	COG3047	cAMP biosynthetic process
FK536_RS12540	COG1607	acyl-coa hydrolase
FK536_RS12545	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FK536_RS12550	COG2350	Protein conserved in bacteria
FK536_RS12555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FK536_RS12575	COG4608	Belongs to the ABC transporter superfamily
FK536_RS12580	COG0444	Belongs to the ABC transporter superfamily
FK536_RS12585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FK536_RS12590	COG0601	transmembrane transport
FK536_RS12595	COG4166	transmembrane transport
FK536_RS12605	COG2095	MarC family integral membrane protein
FK536_RS12610	COG1454	alcohol dehydrogenase
FK536_RS12610	COG1012	belongs to the aldehyde dehydrogenase family
FK536_RS12620	COG1435	thymidine kinase activity
FK536_RS12630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FK536_RS12635	COG0745	RESPONSE REGULATOR receiver
FK536_RS12640	COG1752	Esterase of the alpha-beta hydrolase superfamily
FK536_RS12650	COG0788	formyltetrahydrofolate deformylase activity
FK536_RS12685	COG2181	nitrate reductase activity
FK536_RS12690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FK536_RS12695	COG1140	nitrate reductase beta subunit
FK536_RS12700	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FK536_RS12705	COG2223	nitrite transmembrane transporter activity
FK536_RS12710	COG3850	Histidine kinase
FK536_RS12715	COG2197	response regulator
FK536_RS12720	COG4932	domain protein
FK536_RS12725	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FK536_RS12730	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
FK536_RS12735	COG4572	Cation transport regulator
FK536_RS12740	COG0387	Pfam Sodium calcium exchanger
FK536_RS12765	COG2912	Transglutaminase-like superfamily
FK536_RS12770	COG3094	Invasion gene expression up-regulator, SirB
FK536_RS12775	COG2890	protein-(glutamine-N5) methyltransferase activity
FK536_RS12800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FK536_RS12805	COG0659	secondary active sulfate transmembrane transporter activity
FK536_RS12820	COG0012	GTP binding
FK536_RS12825	COG3468	outer membrane autotransporter barrel domain protein
FK536_RS12830	COG3284	Transcriptional regulator
FK536_RS12835	COG2376	Dihydroxyacetone kinase
FK536_RS12840	COG1461	Dihydroxyacetone kinase
FK536_RS12845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FK536_RS12845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS12845	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FK536_RS12865	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
FK536_RS12875	COG1619	proteins homologs of microcin C7 resistance protein MccF
FK536_RS12885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FK536_RS12895	COG2719	SpoVR family
FK536_RS12910	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FK536_RS12915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FK536_RS12920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FK536_RS12935	COG0179	Fumarylacetoacetate (FAA) hydrolase
FK536_RS12960	COG2894	cell division
FK536_RS13010	COG2200	EAL domain
FK536_RS13040	COG0789	Transcriptional regulator
FK536_RS13045	COG5562	phage envelope protein
FK536_RS13060	COG0538	isocitrate dehydrogenase activity
FK536_RS13065	COG1187	pseudouridine synthase activity
FK536_RS13085	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FK536_RS13090	COG0745	RESPONSE REGULATOR receiver
FK536_RS13095	COG2205	protein histidine kinase activity
FK536_RS13100	COG2850	peptidyl-arginine hydroxylation
FK536_RS13110	COG3842	ATPase activity
FK536_RS13120	COG1177	transmembrane transport
FK536_RS13125	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FK536_RS13135	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FK536_RS13140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FK536_RS13150	COG4591	ABC-type transport system involved in lipoprotein release permease component
FK536_RS13155	COG1136	(ABC) transporter
FK536_RS13160	COG4591	ABC-type transport system involved in lipoprotein release permease component
FK536_RS13165	COG4763	Acyl-transferase
FK536_RS13170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FK536_RS13175	COG1376	ErfK ybiS ycfS ynhG family protein
FK536_RS13175	COG1388	LysM domain
FK536_RS13185	COG1309	transcriptional regulator
FK536_RS13190	COG3134	Outer membrane lipoprotein
FK536_RS13195	COG1252	NADH dehydrogenase
FK536_RS13215	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
FK536_RS13220	COG5633	Lipoprotein
FK536_RS13225	COG0537	adenosine 5'-monophosphoramidase activity
FK536_RS13230	COG4773	Receptor
FK536_RS13235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FK536_RS13235	COG1263	PTS System
FK536_RS13240	COG0084	hydrolase, TatD family'
FK536_RS13245	COG0470	DNA polymerase III
FK536_RS13255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FK536_RS13260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FK536_RS13265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FK536_RS13275	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS13280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FK536_RS13300	COG1399	metal-binding, possibly nucleic acid-binding protein
FK536_RS13305	COG0424	maF-like protein
FK536_RS13310	COG0564	pseudouridine synthase activity
FK536_RS13315	COG1530	ribonuclease E activity
FK536_RS13320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FK536_RS13325	COG1256	bacterial-type flagellum assembly
FK536_RS13330	COG1705	Flagellar rod assembly protein muramidase FlgJ
FK536_RS13330	COG3951	Flagellar rod assembly protein muramidase FlgJ
FK536_RS13335	COG1706	bacterial-type flagellum-dependent cell motility
FK536_RS13345	COG4786	Flagellar basal body rod
FK536_RS13350	COG4787	bacterial-type flagellum-dependent cell motility
FK536_RS13355	COG1749	Flagellar hook protein flgE
FK536_RS13360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FK536_RS13365	COG1558	bacterial-type flagellum-dependent cell motility
FK536_RS13370	COG1815	bacterial-type flagellum-dependent cell motility
FK536_RS13375	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
FK536_RS13380	COG2747	anti-sigma28 factor FlgM
FK536_RS13385	COG3418	PFAM FlgN family protein
FK536_RS13390	COG0728	peptidoglycan biosynthetic process
FK536_RS13395	COG0673	inositol 2-dehydrogenase activity
FK536_RS13405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FK536_RS13415	COG2999	glutathione oxidoreductase activity
FK536_RS13450	COG3038	cytochrome b561
FK536_RS13455	COG2353	YceI-like domain
FK536_RS13465	COG1560	Kdo2-lipid A biosynthetic process
FK536_RS13480	COG5645	(Lipo)protein
FK536_RS13485	COG2943	transferase activity, transferring hexosyl groups
FK536_RS13500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FK536_RS13505	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FK536_RS13530	COG2197	response regulator
FK536_RS13545	COG1462	curli production assembly transport component CsgG
FK536_RS13555	COG3381	protein complex oligomerization
FK536_RS13585	COG3706	GGDEF domain
FK536_RS13590	COG0457	Tetratricopeptide repeat
FK536_RS13595	COG0726	polysaccharide deacetylase
FK536_RS13595	COG1649	PFAM Uncharacterised BCR, COG1649
FK536_RS13600	COG1215	transferase activity, transferring glycosyl groups
FK536_RS13605	COG3658	cytochrome
FK536_RS13610	COG1702	phosphate starvation-inducible protein PhoH
FK536_RS13620	COG2822	iron ion transport
FK536_RS13630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FK536_RS13640	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FK536_RS13640	COG0506	proline dehydrogenase activity
FK536_RS13640	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FK536_RS13645	COG1309	transcriptional regulator
FK536_RS13680	COG2233	PERMEase
FK536_RS13685	COG3729	General stress protein
FK536_RS13725	COG0243	molybdopterin cofactor binding
FK536_RS13730	COG3005	denitrification pathway
FK536_RS13735	COG0745	RESPONSE REGULATOR receiver
FK536_RS13740	COG1879	ABC-type sugar transport system periplasmic component
FK536_RS13745	COG2205	protein histidine kinase activity
FK536_RS13745	COG2198	Histidine kinase
FK536_RS13745	COG0784	Response regulator, receiver
FK536_RS13750	COG0348	domain, Protein
FK536_RS13770	COG1278	Cold shock
FK536_RS13775	COG1278	Cold shock
FK536_RS13795	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK536_RS13800	COG1596	polysaccharide export
FK536_RS13805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FK536_RS13810	COG3206	protein involved in exopolysaccharide biosynthesis
FK536_RS13810	COG0489	protein tyrosine kinase activity
FK536_RS13825	COG1294	oxidase, subunit
FK536_RS13830	COG1271	oxidase subunit
FK536_RS13835	COG1773	rubredoxin
FK536_RS13840	COG1999	signal sequence binding
FK536_RS13845	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FK536_RS13850	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
FK536_RS13855	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FK536_RS13860	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FK536_RS13870	COG0670	Belongs to the BI1 family
FK536_RS13875	COG2920	part of a sulfur-relay system
FK536_RS13880	COG1254	Belongs to the acylphosphatase family
FK536_RS13895	COG1832	CoA-binding protein
FK536_RS13910	COG0210	DNA helicase
FK536_RS13915	COG3304	Inner membrane component domain
FK536_RS13920	COG1289	transmembrane transporter activity
FK536_RS13925	COG3070	regulator of competence-specific genes
FK536_RS13935	COG2885	chlorophyll binding
FK536_RS13935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FK536_RS13945	COG1067	ATP-dependent peptidase activity
FK536_RS13955	COG3130	regulation of translation
FK536_RS13960	COG3009	Protein conserved in bacteria
FK536_RS13965	COG3008	intermembrane lipid transfer
FK536_RS13965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FK536_RS13970	COG2995	paraquat-inducible protein a
FK536_RS13975	COG0488	(ABC) transporter
FK536_RS13985	COG3217	Mosc domain protein beta barrel domain protein
FK536_RS13985	COG0633	Ferredoxin
FK536_RS14000	COG3121	Chaperone
FK536_RS14005	COG3539	Fimbrial protein
FK536_RS14010	COG3539	Fimbrial protein
FK536_RS14015	COG3539	Fimbrial protein
FK536_RS14020	COG3188	usher protein
FK536_RS14025	COG3121	Chaperone
FK536_RS14030	COG3539	Fimbrial protein
FK536_RS14035	COG0431	NADPH-dependent FMN reductase
FK536_RS14040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FK536_RS14050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FK536_RS14055	COG1116	anion transmembrane transporter activity
FK536_RS14060	COG0308	aminopeptidase N
FK536_RS14075	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FK536_RS14080	COG1448	Aminotransferase
FK536_RS14085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FK536_RS14090	COG3108	Peptidase M15
FK536_RS14095	COG2989	Protein conserved in bacteria
FK536_RS14105	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FK536_RS14115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FK536_RS14120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FK536_RS14125	COG3173	Aminoglycoside phosphotransferase
FK536_RS14140	COG3214	Protein conserved in bacteria
FK536_RS14145	COG1663	tetraacyldisaccharide 4'-kinase activity
FK536_RS14150	COG1132	(ABC) transporter
FK536_RS14165	COG0539	negative regulation of cytoplasmic translation
FK536_RS14175	COG0501	Belongs to the peptidase M48B family
FK536_RS14190	COG2323	membrane
FK536_RS14195	COG1944	ATP diphosphatase activity
FK536_RS14200	COG2116	formate transmembrane transporter activity
FK536_RS14205	COG1882	Formate acetyltransferase
FK536_RS14210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FK536_RS14220	COG2249	NAD(P)H dehydrogenase (quinone) activity
FK536_RS14225	COG0583	DNA-binding transcription factor activity
FK536_RS14230	COG0531	amino acid
FK536_RS14240	COG1335	isochorismatase
FK536_RS14245	COG3302	dmso reductase anchor subunit
FK536_RS14250	COG0437	4 iron, 4 sulfur cluster binding
FK536_RS14255	COG0243	molybdopterin cofactor binding
FK536_RS14265	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FK536_RS14275	COG1178	ABC-type Fe3 transport system permease component
FK536_RS14275	COG1674	ftsk spoiiie
FK536_RS14280	COG1522	sequence-specific DNA binding
FK536_RS14285	COG0492	ferredoxin-NADP+ reductase activity
FK536_RS14290	COG4988	ABC transporter
FK536_RS14295	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FK536_RS14315	COG0542	response to heat
FK536_RS14325	COG1278	Cold shock
FK536_RS14330	COG1136	(ABC) transporter
FK536_RS14330	COG0577	efflux transmembrane transporter activity
FK536_RS14335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK536_RS14340	COG2990	Protein conserved in bacteria
FK536_RS14345	COG3593	DNA synthesis involved in DNA repair
FK536_RS14355	COG2431	L-lysine efflux transmembrane transporter activity
FK536_RS14365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FK536_RS14370	COG0028	Belongs to the TPP enzyme family
FK536_RS14375	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FK536_RS14380	COG0702	epimerase
FK536_RS14385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FK536_RS14390	COG3023	N-Acetylmuramoyl-L-alanine amidase
FK536_RS14405	COG1126	abc transporter atp-binding protein
FK536_RS14410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FK536_RS14415	COG4215	(ABC) transporter
FK536_RS14420	COG4160	amino acid transport
FK536_RS14425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FK536_RS14440	COG1177	transmembrane transport
FK536_RS14445	COG1176	ABC-type spermidine putrescine transport system, permease component I
FK536_RS14450	COG3842	ATPase activity
FK536_RS14455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FK536_RS14480	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FK536_RS14495	COG3226	Transcriptional regulator
FK536_RS14500	COG0738	Major facilitator superfamily
FK536_RS14505	COG0561	phosphatase activity
FK536_RS14515	COG2814	Major facilitator Superfamily
FK536_RS14520	COG0671	phosphoesterase, PA-phosphatase related
FK536_RS14525	COG1349	DNA-binding transcription factor activity
FK536_RS14530	COG1686	Belongs to the peptidase S11 family
FK536_RS14535	COG0625	glutathione transferase activity
FK536_RS14540	COG2133	pyrroloquinoline quinone binding
FK536_RS14555	COG2199	diguanylate cyclase activity
FK536_RS14560	COG2200	EAL domain
FK536_RS14565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FK536_RS14575	COG0747	negative chemotaxis
FK536_RS14580	COG4172	Belongs to the ABC transporter superfamily
FK536_RS14585	COG1446	asparaginase
FK536_RS14590	COG0303	'Molybdopterin
FK536_RS14595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FK536_RS14600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FK536_RS14605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FK536_RS14610	COG1882	Formate acetyltransferase
FK536_RS14615	COG0561	phosphatase activity
FK536_RS14625	COG0488	(ABC) transporter
FK536_RS14630	COG1376	ErfK ybiS ycfS ynhG family protein
FK536_RS14635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FK536_RS14640	COG1321	iron dependent repressor
FK536_RS14650	COG2194	sulfuric ester hydrolase activity
FK536_RS14655	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FK536_RS14665	COG5006	permease, DMT superfamily
FK536_RS14675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FK536_RS14680	COG0765	amino acid transport
FK536_RS14685	COG1126	abc transporter atp-binding protein
FK536_RS14690	COG0668	transmembrane transport
FK536_RS14705	COG4774	siderophore transport
FK536_RS14715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FK536_RS14725	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FK536_RS14730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FK536_RS14735	COG1199	ATP-dependent helicase activity
FK536_RS14740	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FK536_RS14745	COG0513	Belongs to the DEAD box helicase family
FK536_RS14750	COG1309	transcriptional regulator
FK536_RS14760	COG1131	(ABC) transporter
FK536_RS14765	COG0842	Transport permease protein
FK536_RS14770	COG0842	Transport permease protein
FK536_RS14780	COG3568	Endonuclease Exonuclease Phosphatase
FK536_RS14785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FK536_RS14790	COG0392	lysyltransferase activity
FK536_RS14795	COG0670	Belongs to the BI1 family
FK536_RS14800	COG0670	Belongs to the BI1 family
FK536_RS14805	COG0314	molybdopterin synthase activity
FK536_RS14810	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FK536_RS14820	COG0521	Mo-molybdopterin cofactor biosynthetic process
FK536_RS14830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FK536_RS14840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FK536_RS14845	COG2226	methyltransferase
FK536_RS14860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FK536_RS14865	COG1881	PFAM PEBP family protein
FK536_RS14870	COG4677	pectinesterase activity
FK536_RS14875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FK536_RS14880	COG0471	metal ion transport
FK536_RS14885	COG2828	Protein conserved in bacteria
FK536_RS14890	COG0583	DNA-binding transcription factor activity
FK536_RS14900	COG0561	phosphatase activity
FK536_RS14905	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FK536_RS14910	COG4149	molybdate abc transporter
FK536_RS14915	COG0725	ABC transporter, periplasmic molybdate-binding protein
FK536_RS14925	COG3585	molybdate ion transport
FK536_RS14925	COG2005	Transcriptional regulator
FK536_RS14930	COG1119	ATPase activity
FK536_RS14935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FK536_RS14940	COG1085	galactose-1-phosphate uridylyltransferase
FK536_RS14950	COG2017	converts alpha-aldose to the beta-anomer
FK536_RS14960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FK536_RS14970	COG1230	cation diffusion facilitator family transporter
FK536_RS14975	COG3201	nicotinamide mononucleotide transporter
FK536_RS15020	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FK536_RS15025	COG2885	chlorophyll binding
FK536_RS15035	COG3064	Membrane
FK536_RS15040	COG0848	biopolymer transport protein
FK536_RS15045	COG0811	peptide transport
FK536_RS15050	COG0824	Thioesterase
FK536_RS15055	COG3790	cyd operon protein YbgE
FK536_RS15060	COG4890	Cyd operon protein YbgT
FK536_RS15065	COG1294	oxidase, subunit
FK536_RS15070	COG1271	oxidase subunit
FK536_RS15080	COG0383	alpha-mannosidase activity
FK536_RS15085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS15085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS15085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS15090	COG2188	Transcriptional regulator
FK536_RS15095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FK536_RS15105	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK536_RS15110	COG0567	Dehydrogenase, E1 component
FK536_RS15115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FK536_RS15120	COG1053	succinate dehydrogenase
FK536_RS15125	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FK536_RS15130	COG2009	succinate dehydrogenase
FK536_RS15140	COG0372	Belongs to the citrate synthase family
FK536_RS15145	COG3539	Fimbrial protein
FK536_RS15150	COG3188	usher protein
FK536_RS15155	COG3121	Chaperone
FK536_RS15160	COG3539	Fimbrial protein
FK536_RS15165	COG3180	Ammonia monooxygenase
FK536_RS15180	COG1984	allophanate hydrolase subunit 2
FK536_RS15185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FK536_RS15190	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FK536_RS15195	COG3104	oligopeptide transport
FK536_RS15200	COG0415	Belongs to the DNA photolyase family
FK536_RS15205	COG3272	Protein of unknown function (DUF1722)
FK536_RS15250	COG2205	protein histidine kinase activity
FK536_RS15255	COG0745	RESPONSE REGULATOR receiver
FK536_RS15265	COG1982	Orn Lys Arg decarboxylase major
FK536_RS15270	COG0531	amino acid
FK536_RS15290	COG0033	Phosphoglucomutase
FK536_RS15295	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FK536_RS15300	COG0596	Alpha beta hydrolase
FK536_RS15310	COG0716	FMN binding
FK536_RS15320	COG0735	belongs to the Fur family
FK536_RS15340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FK536_RS15340	COG2190	(PTS) system
FK536_RS15340	COG1263	PTS System
FK536_RS15350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FK536_RS15355	COG1846	Transcriptional regulator
FK536_RS15355	COG1940	carbohydrate kinase activity
FK536_RS15360	COG0647	UMP catabolic process
FK536_RS15365	COG0367	asparagine synthase
FK536_RS15405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FK536_RS15415	COG1702	phosphate starvation-inducible protein PhoH
FK536_RS15425	COG4535	Mg2 and Co2 transporter CorC
FK536_RS15430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FK536_RS15435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FK536_RS15440	COG0765	amino acid transport
FK536_RS15445	COG0765	amino acid transport
FK536_RS15450	COG1126	abc transporter atp-binding protein
FK536_RS15465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FK536_RS15470	COG2888	peptidyl-tyrosine sulfation
FK536_RS15485	COG1466	dna polymerase III delta subunit
FK536_RS15495	COG0406	alpha-ribazole phosphatase activity
FK536_RS15500	COG0799	negative regulation of ribosome biogenesis
FK536_RS15510	COG0768	penicillin binding
FK536_RS15515	COG0772	Belongs to the SEDS family
FK536_RS15520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FK536_RS15525	COG1686	Belongs to the peptidase S11 family
FK536_RS15560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FK536_RS15565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK536_RS15585	COG3069	C4-dicarboxylate transmembrane transporter activity
FK536_RS15590	COG4565	transcriptional regulatory protein
FK536_RS15595	COG3290	protein histidine kinase activity
FK536_RS15600	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
FK536_RS15610	COG2301	Belongs to the HpcH HpaI aldolase family
FK536_RS15615	COG3051	citrate lyase alpha subunit
FK536_RS15630	COG0471	metal ion transport
FK536_RS15635	COG3719	Belongs to the RNase T2 family
FK536_RS15640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FK536_RS15645	COG1063	alcohol dehydrogenase
FK536_RS15650	COG0589	response to stress
FK536_RS15655	COG3634	alkyl hydroperoxide reductase activity
FK536_RS15660	COG0450	alkyl hydroperoxide reductase
FK536_RS15665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FK536_RS15670	COG0583	DNA-binding transcription factor activity
FK536_RS15675	COG3969	phosphoadenosine phosphosulfate
FK536_RS15680	COG1475	DNA binding
FK536_RS15685	COG0436	Aminotransferase
FK536_RS15690	COG0371	Dehydrogenase
FK536_RS15695	COG2879	small protein
FK536_RS15700	COG1966	Carbon starvation protein
FK536_RS15705	COG2050	protein possibly involved in aromatic compounds catabolism
FK536_RS15710	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS15715	COG1535	isochorismatase
FK536_RS15715	COG3433	isochorismatase activity
FK536_RS15720	COG1021	2,3-dihydroxybenzoate-AMP ligase
FK536_RS15725	COG1169	isochorismate synthase
FK536_RS15730	COG4592	Periplasmic binding protein
FK536_RS15740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FK536_RS15745	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FK536_RS15750	COG1120	ATPase activity
FK536_RS15755	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
FK536_RS15760	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
FK536_RS15760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FK536_RS15765	COG3251	PFAM MbtH domain protein
FK536_RS15770	COG2382	esterase
FK536_RS15775	COG4771	TonB-dependent receptor
FK536_RS15780	COG2977	Belongs to the P-Pant transferase superfamily
FK536_RS15785	COG3385	transposase activity
FK536_RS15810	COG2315	Protein conserved in bacteria
FK536_RS15815	COG0778	Nitroreductase
FK536_RS15820	COG0668	transmembrane transport
FK536_RS15825	COG1113	amino acid transport
FK536_RS15830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK536_RS15835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK536_RS15840	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK536_RS15845	COG1538	Outer membrane efflux protein
FK536_RS15850	COG0745	RESPONSE REGULATOR receiver
FK536_RS15855	COG5002	protein histidine kinase activity
FK536_RS15865	COG2207	Transcriptional regulator
FK536_RS15875	COG2197	response regulator
FK536_RS15880	COG3539	Fimbrial protein
FK536_RS15885	COG3539	Fimbrial protein
FK536_RS15890	COG3188	usher protein
FK536_RS15895	COG3121	Chaperone
FK536_RS15900	COG3539	Fimbrial protein
FK536_RS15910	COG2501	S4 domain
FK536_RS15915	COG1988	membrane-bound metal-dependent
FK536_RS15925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FK536_RS15935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FK536_RS15940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FK536_RS15945	COG0549	Belongs to the carbamate kinase family
FK536_RS15955	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FK536_RS15960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FK536_RS15965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FK536_RS15970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FK536_RS15975	COG3257	ureidoglycine aminohydrolase activity
FK536_RS15980	COG1929	Belongs to the glycerate kinase type-1 family
FK536_RS15985	COG2233	PERMEase
FK536_RS16000	COG2084	Dehydrogenase
FK536_RS16005	COG3622	Belongs to the hyi family
FK536_RS16010	COG3960	tartronate-semialdehyde synthase activity
FK536_RS16015	COG1414	Transcriptional regulator
FK536_RS16025	COG0583	DNA-binding transcription factor activity
FK536_RS16060	COG3209	COG3209 Rhs family protein
FK536_RS16065	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FK536_RS16070	COG4181	ATPase activity
FK536_RS16075	COG2755	lipolytic protein G-D-S-L family
FK536_RS16080	COG0300	oxidoreductase activity
FK536_RS16085	COG3118	belongs to the thioredoxin family
FK536_RS16090	COG0390	transport system, permease component
FK536_RS16095	COG4619	ABC transporter
FK536_RS16100	COG0330	HflC and HflK could
FK536_RS16105	COG1585	Membrane protein implicated in regulation of membrane protease activity
FK536_RS16110	COG0789	Transcriptional regulator
FK536_RS16115	COG0531	amino acid
FK536_RS16120	COG2066	Belongs to the glutaminase family
FK536_RS16125	COG2217	Heavy metal translocating P-type atpase
FK536_RS16130	COG3093	addiction module antidote protein HigA
FK536_RS16135	COG3735	TraB family
FK536_RS16140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FK536_RS16145	COG0737	Belongs to the 5'-nucleotidase family
FK536_RS16150	COG2223	nitrite transmembrane transporter activity
FK536_RS16155	COG4651	solute:proton antiporter activity
FK536_RS16155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FK536_RS16160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK536_RS16195	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FK536_RS16205	COG2832	Protein of unknown function (DUF454)
FK536_RS16210	COG3923	Primosomal replication protein n
FK536_RS16220	COG1196	nuclear chromosome segregation
FK536_RS16220	COG3264	Mechanosensitive ion channel
FK536_RS16225	COG1309	transcriptional regulator
FK536_RS16230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK536_RS16235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FK536_RS16250	COG0110	maltose O-acetyltransferase activity
FK536_RS16260	COG4943	cyclic-guanylate-specific phosphodiesterase activity
FK536_RS16275	COG3695	enzyme binding
FK536_RS16280	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FK536_RS16285	COG1946	Acyl-CoA thioesterase
FK536_RS16290	COG0004	ammonium transporteR
FK536_RS16295	COG0347	Belongs to the P(II) protein family
FK536_RS16300	COG1132	(ABC) transporter
FK536_RS16305	COG1132	(ABC) transporter
FK536_RS16310	COG1522	sequence-specific DNA binding
FK536_RS16320	COG4533	DNA binding
FK536_RS16330	COG0824	Thioesterase
FK536_RS16335	COG1555	photosystem II stabilization
FK536_RS16340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK536_RS16345	COG0776	regulation of translation
FK536_RS16350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FK536_RS16370	COG0271	Belongs to the BolA IbaG family
FK536_RS16375	COG3056	Lipoprotein
FK536_RS16380	COG2223	nitrite transmembrane transporter activity
FK536_RS16385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FK536_RS16390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FK536_RS16395	COG1845	cytochrome c oxidase, subunit III
FK536_RS16400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FK536_RS16410	COG2814	Major facilitator Superfamily
FK536_RS16420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FK536_RS16425	COG0693	protein deglycase activity
FK536_RS16440	COG0142	geranyltranstransferase activity
FK536_RS16450	COG0667	Aldo Keto reductase
FK536_RS16455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FK536_RS16460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FK536_RS16475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK536_RS16475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FK536_RS16485	COG4238	major outer membrane lipoprotein
FK536_RS16490	COG3248	Nucleoside-binding outer membrane protein
FK536_RS16495	COG1403	HNH endonuclease
FK536_RS16500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FK536_RS16505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FK536_RS16510	COG1862	Preprotein translocase
FK536_RS16530	COG0366	Alpha amylase catalytic
FK536_RS16535	COG1113	amino acid transport
FK536_RS16540	COG1114	Component of the transport system for branched-chain amino acids
FK536_RS16545	COG5002	protein histidine kinase activity
FK536_RS16550	COG0745	RESPONSE REGULATOR receiver
FK536_RS16555	COG0420	3'-5' exonuclease activity
FK536_RS16560	COG0419	ATPase involved in DNA repair
FK536_RS16565	COG2814	Major facilitator Superfamily
FK536_RS16570	COG1940	carbohydrate kinase activity
FK536_RS16595	COG4126	flavin adenine dinucleotide binding
FK536_RS16615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FK536_RS16620	COG3706	GGDEF domain
FK536_RS16630	COG1785	Belongs to the alkaline phosphatase family
FK536_RS16645	COG1181	Belongs to the D-alanine--D-alanine ligase family
FK536_RS16665	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FK536_RS16670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FK536_RS16675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FK536_RS16695	COG0113	porphobilinogen synthase activity
FK536_RS16700	COG2175	clavaminate synthase activity
FK536_RS16705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FK536_RS16710	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
FK536_RS16715	COG4521	taurine ABC transporter
FK536_RS16725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FK536_RS16730	COG1215	transferase activity, transferring glycosyl groups
FK536_RS16760	COG3122	Protein conserved in bacteria
FK536_RS16765	COG2814	Major facilitator Superfamily
FK536_RS16780	COG3971	2-oxopent-4-enoate hydratase activity
FK536_RS16800	COG1414	Transcriptional regulator
FK536_RS16805	COG1609	Transcriptional regulator
FK536_RS16810	COG3250	beta-galactosidase activity
FK536_RS16815	COG2223	nitrite transmembrane transporter activity
FK536_RS16820	COG0110	maltose O-acetyltransferase activity
FK536_RS16825	COG2807	transmembrane transport
FK536_RS16835	COG0288	reversible hydration of carbon dioxide
FK536_RS16840	COG0583	DNA-binding transcription factor activity
FK536_RS16845	COG0402	S-adenosylhomocysteine deaminase activity
FK536_RS16850	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FK536_RS16855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FK536_RS16860	COG2079	MmgE PrpD family protein
FK536_RS16865	COG0372	Belongs to the citrate synthase family
FK536_RS16870	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FK536_RS16875	COG3829	transcription factor binding
FK536_RS16890	COG1280	lysine exporter protein (LysE YggA)
FK536_RS16905	COG1064	alcohol dehydrogenase
FK536_RS16910	COG0402	S-adenosylhomocysteine deaminase activity
FK536_RS16915	COG0549	Belongs to the carbamate kinase family
FK536_RS16925	COG1304	FMN binding
FK536_RS16930	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FK536_RS16940	COG0666	response to abiotic stimulus
FK536_RS16950	COG0583	DNA-binding transcription factor activity
FK536_RS16955	COG2771	luxR family
FK536_RS16955	COG2200	EAL domain
FK536_RS16970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FK536_RS16995	COG1556	Lactate utilization protein
FK536_RS17000	COG1139	Iron-sulfur cluster binding protein
FK536_RS17005	COG0247	lactate metabolic process
FK536_RS17010	COG2207	Transcriptional regulator
FK536_RS17035	COG3059	membrane
FK536_RS17045	COG3708	Transcriptional regulator
FK536_RS17045	COG2207	Transcriptional regulator
FK536_RS17090	COG3188	usher protein
FK536_RS17100	COG3121	Chaperone
FK536_RS17105	COG0727	PFAM Uncharacterised protein family (UPF0153)
FK536_RS17110	COG3477	response to acidic pH
FK536_RS17115	COG2080	2 iron, 2 sulfur cluster binding
FK536_RS17120	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
FK536_RS17125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
FK536_RS17130	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FK536_RS17135	COG0583	DNA-binding transcription factor activity
FK536_RS17150	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FK536_RS17155	COG5301	cellulose 1,4-beta-cellobiosidase activity
FK536_RS17170	COG4220	transposase activity
FK536_RS17225	COG0582	viral genome integration into host DNA
FK536_RS17240	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FK536_RS17300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FK536_RS17310	COG2076	Multidrug Resistance protein
FK536_RS17390	COG3093	addiction module antidote protein HigA
FK536_RS17430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FK536_RS17445	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FK536_RS17455	COG3778	Protein conserved in bacteria
FK536_RS17460	COG3299	homolog of phage Mu protein gp47
FK536_RS17480	COG4228	DNA circulation
FK536_RS17510	COG4386	tail sheath protein
FK536_RS17555	COG4695	Portal protein
FK536_RS17565	COG4626	Terminase
FK536_RS17565	COG1802	Transcriptional regulator
FK536_RS17620	COG1403	HNH endonuclease
FK536_RS17630	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
FK536_RS17645	COG1846	Transcriptional regulator
FK536_RS17660	COG4197	protein conserved in bacteria, prophage-related
FK536_RS17665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FK536_RS17680	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FK536_RS17695	COG0582	viral genome integration into host DNA
FK536_RS17715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FK536_RS17735	COG2195	Cleaves the N-terminal amino acid of tripeptides
FK536_RS17740	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FK536_RS17745	COG1690	Belongs to the RtcB family
FK536_RS17750	COG0454	-acetyltransferase
FK536_RS17765	COG2161	toxin-antitoxin pair type II binding
FK536_RS17785	COG1943	Transposase
FK536_RS17790	COG0791	NLP P60 protein
FK536_RS17795	COG3077	Addiction module antitoxin, RelB DinJ family
FK536_RS17800	COG3041	Addiction module toxin RelE StbE family
FK536_RS17805	COG3034	peptidoglycan biosynthetic process
FK536_RS17810	COG0121	glutamine amidotransferase
FK536_RS17820	COG1960	acyl-CoA dehydrogenase activity
FK536_RS17830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FK536_RS17835	COG5433	transposase activity
FK536_RS17860	COG3157	Type VI secretion system effector, Hcp
FK536_RS17865	COG4104	PAAR repeat-containing protein
FK536_RS17885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FK536_RS17895	COG2226	methyltransferase
FK536_RS17905	COG0741	lytic transglycosylase activity
FK536_RS17905	COG1388	LysM domain
FK536_RS17920	COG0583	DNA-binding transcription factor activity
FK536_RS17925	COG0656	L-ascorbic acid biosynthetic process
FK536_RS17960	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FK536_RS17965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FK536_RS17970	COG2011	ABC-type metal ion transport system permease component
FK536_RS17975	COG1464	Belongs to the NlpA lipoprotein family
FK536_RS17985	COG1720	tRNA m6t6A37 methyltransferase activity
FK536_RS17995	COG0791	NLP P60 protein
FK536_RS18000	COG3015	lipoprotein NlpE involved in copper resistance
FK536_RS18005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FK536_RS18010	COG4681	YaeQ
FK536_RS18020	COG4568	rho-dependent transcription termination
FK536_RS18025	COG0037	tRNA processing
FK536_RS18030	COG0346	lactoylglutathione lyase activity
FK536_RS18045	COG0587	DNA-directed DNA polymerase activity
FK536_RS18070	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FK536_RS18075	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FK536_RS18085	COG0750	zinc metalloprotease
FK536_RS18090	COG0575	Belongs to the CDS family
FK536_RS18095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FK536_RS18100	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FK536_RS18125	COG0024	Methionine aminopeptidase
FK536_RS18140	COG1408	metallophosphoesterase
FK536_RS18150	COG3835	regulator
FK536_RS18155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FK536_RS18170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FK536_RS18175	COG2860	membrane
FK536_RS18200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FK536_RS18205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FK536_RS18210	COG1120	ATPase activity
FK536_RS18215	COG4774	siderophore transport
FK536_RS18220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FK536_RS18225	COG1643	Atp-dependent helicase
FK536_RS18230	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FK536_RS18240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FK536_RS18250	COG0617	tRNA 3'-terminal CCA addition
FK536_RS18255	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FK536_RS18260	COG3539	Fimbrial protein
FK536_RS18265	COG3121	Chaperone
FK536_RS18295	COG5464	transposase or invertase
FK536_RS18305	COG0726	polysaccharide deacetylase
FK536_RS18310	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS18315	COG0842	Transport permease protein
FK536_RS18320	COG1131	(ABC) transporter
FK536_RS18325	COG0288	reversible hydration of carbon dioxide
FK536_RS18330	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FK536_RS18335	COG4993	Dehydrogenase
FK536_RS18340	COG2132	Multicopper oxidase
FK536_RS18365	COG1049	propionate catabolic process, 2-methylcitrate cycle
FK536_RS18370	COG3064	Membrane
FK536_RS18375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK536_RS18380	COG0508	dehydrogenase complex catalyzes the overall conversion of
FK536_RS18385	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FK536_RS18390	COG2186	Transcriptional regulator
FK536_RS18395	COG1113	amino acid transport
FK536_RS18400	COG3725	Membrane protein required for beta-lactamase induction
FK536_RS18405	COG3023	N-Acetylmuramoyl-L-alanine amidase
FK536_RS18410	COG0157	Belongs to the NadC ModD family
FK536_RS18415	COG4969	Belongs to the N-Me-Phe pilin family
FK536_RS18420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FK536_RS18425	COG1459	type II secretion system
FK536_RS18435	COG0237	dephospho-CoA kinase activity
FK536_RS18450	COG0494	nUDIX hydrolase
FK536_RS18470	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FK536_RS18475	COG0849	cell division
FK536_RS18480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FK536_RS18485	COG1181	Belongs to the D-alanine--D-alanine ligase family
FK536_RS18500	COG0772	Belongs to the SEDS family
FK536_RS18505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FK536_RS18515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FK536_RS18520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FK536_RS18525	COG0768	penicillin binding
FK536_RS18530	COG3116	cell division
FK536_RS18540	COG2001	Belongs to the MraZ family
FK536_RS18545	COG1609	Transcriptional regulator
FK536_RS18555	COG0440	acetolactate synthase activity
FK536_RS18560	COG0028	Belongs to the TPP enzyme family
FK536_RS18570	COG0583	DNA-binding transcription factor activity
FK536_RS18590	COG0473	3-isopropylmalate dehydrogenase activity
FK536_RS18605	COG2814	Major facilitator Superfamily
FK536_RS18615	COG4533	DNA binding
FK536_RS18620	COG4143	(ABC) transporter
FK536_RS18625	COG1178	ABC-type Fe3 transport system permease component
FK536_RS18630	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FK536_RS18635	COG0586	Pfam SNARE associated Golgi protein
FK536_RS18640	COG4977	sequence-specific DNA binding
FK536_RS18645	COG1069	ribulokinase activity
FK536_RS18650	COG2160	L-arabinose isomerase activity
FK536_RS18655	COG0235	Class ii aldolase
FK536_RS18660	COG0417	DNA replication proofreading
FK536_RS18670	COG0564	pseudouridine synthase activity
FK536_RS18690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FK536_RS18695	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FK536_RS18700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK536_RS18725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FK536_RS18740	COG2271	Major facilitator Superfamily
FK536_RS18745	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
FK536_RS18750	COG0644	oxidoreductase
FK536_RS18800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FK536_RS18805	COG0505	Belongs to the CarA family
FK536_RS18825	COG1047	Peptidyl-prolyl cis-trans
FK536_RS18840	COG0196	riboflavin kinase activity
FK536_RS18870	COG0583	DNA-binding transcription factor activity
FK536_RS18900	COG4735	regulation of single-species biofilm formation
FK536_RS18905	COG1584	GPR1 FUN34 yaaH family protein
FK536_RS18910	COG0521	Mo-molybdopterin cofactor biosynthetic process
FK536_RS18920	COG1115	amino acid carrier protein
FK536_RS18935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FK536_RS18945	COG0460	homoserine dehydrogenase
FK536_RS18945	COG0527	aspartate kinase activity
FK536_RS18955	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FK536_RS18965	COG0745	RESPONSE REGULATOR receiver
FK536_RS18970	COG4452	Inner membrane protein CreD
FK536_RS18975	COG2205	protein histidine kinase activity
FK536_RS18980	COG0745	RESPONSE REGULATOR receiver
FK536_RS18985	COG3045	CreA protein
FK536_RS18990	COG2207	Transcriptional regulator
FK536_RS18990	COG3708	Transcriptional regulator
FK536_RS19010	COG0741	lytic transglycosylase activity
FK536_RS19015	COG0488	(ABC) transporter
FK536_RS19020	COG1056	cytidyltransferase-related domain
FK536_RS19020	COG3172	ATPase kinase involved in NAD metabolism
FK536_RS19025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FK536_RS19030	COG0560	Phosphoserine phosphatase
FK536_RS19035	COG3726	membrane protein affecting hemolysin expression
FK536_RS19070	COG1328	CTP reductase activity
FK536_RS19075	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FK536_RS19080	COG0084	hydrolase, TatD family'
FK536_RS19085	COG4667	esterase of the alpha-beta hydrolase superfamily
FK536_RS19095	COG2823	Periplasmic or secreted lipoprotein
FK536_RS19105	COG1011	Hydrolase
FK536_RS19110	COG0456	acetyltransferase
FK536_RS19115	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
FK536_RS19145	COG4114	ferric iron reductase
FK536_RS19150	COG2197	response regulator
FK536_RS19155	COG2197	response regulator
FK536_RS19160	COG2966	Psort location CytoplasmicMembrane, score
FK536_RS19175	COG1484	DNA-dependent DNA replication
FK536_RS19190	COG1063	alcohol dehydrogenase
FK536_RS19200	COG1802	Transcriptional regulator
FK536_RS19205	COG0025	NhaP-type Na H and K H
FK536_RS19210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FK536_RS19225	COG0840	transmembrane signaling receptor activity
FK536_RS19230	COG1846	Transcriptional regulator
FK536_RS19235	COG0179	Fumarylacetoacetate (FAA) hydrolase
FK536_RS19240	COG1012	belongs to the aldehyde dehydrogenase family
FK536_RS19245	COG3384	dioxygenase
FK536_RS19255	COG3971	2-oxopent-4-enoate hydratase activity
FK536_RS19275	COG2368	4-hydroxyphenylacetate
FK536_RS19280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FK536_RS19285	COG1966	Carbon starvation protein
FK536_RS19290	COG2879	small protein
FK536_RS19295	COG0523	cobalamin synthesis protein
FK536_RS19340	COG5457	Domain of unknown function (DUF1127)
FK536_RS19345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FK536_RS19355	COG2814	Major facilitator Superfamily
FK536_RS19360	COG2733	membrane
FK536_RS19365	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
FK536_RS19370	COG1924	4 iron, 4 sulfur cluster binding
FK536_RS19385	COG0477	Major facilitator Superfamily
FK536_RS19395	COG3366	ferrous iron transmembrane transporter activity
FK536_RS19400	COG0700	Nucleoside recognition
FK536_RS19405	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FK536_RS19410	COG0583	DNA-binding transcription factor activity
FK536_RS19430	COG2186	Transcriptional regulator
FK536_RS19435	COG0246	Mannitol dehydrogenase
FK536_RS19450	COG3539	Fimbrial protein
FK536_RS19455	COG3539	Fimbrial protein
FK536_RS19460	COG3539	Fimbrial protein
FK536_RS19480	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FK536_RS19485	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
FK536_RS19510	COG1401	restriction endodeoxyribonuclease activity
FK536_RS19550	COG1064	alcohol dehydrogenase
FK536_RS19555	COG0433	COG0433 Predicted ATPase
FK536_RS19560	COG0795	lipopolysaccharide-transporting ATPase activity
FK536_RS19565	COG0795	lipopolysaccharide-transporting ATPase activity
FK536_RS19575	COG2927	DNA polymerase III (CHI subunit)
FK536_RS19585	COG4269	membrane
FK536_RS19590	COG0456	acetyltransferase
FK536_RS19595	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
FK536_RS19610	COG2731	YhcH YjgK YiaL family protein
FK536_RS19615	COG1309	transcriptional regulator
FK536_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS19625	COG0251	oxidation-reduction process
FK536_RS19645	COG0251	oxidation-reduction process
FK536_RS19650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FK536_RS19660	COG1609	Transcriptional regulator
FK536_RS19665	COG1263	PTS System
FK536_RS19665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FK536_RS19670	COG0366	Alpha amylase catalytic
FK536_RS19675	COG1328	CTP reductase activity
FK536_RS19680	COG0602	queuosine metabolic process
FK536_RS19685	COG3783	Cytochrome b(562)
FK536_RS19690	COG0312	modulator of DNA gyrase
FK536_RS19700	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FK536_RS19710	COG1172	Belongs to the binding-protein-dependent transport system permease family
FK536_RS19715	COG1172	Belongs to the binding-protein-dependent transport system permease family
FK536_RS19720	COG1129	ABC transporter
FK536_RS19725	COG1879	ABC-type sugar transport system periplasmic component
FK536_RS19730	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FK536_RS19735	COG2105	PFAM AIG2 family protein
FK536_RS19740	COG2911	Protein conserved in bacteria
FK536_RS19745	COG0729	surface antigen
FK536_RS19755	COG1253	flavin adenine dinucleotide binding
FK536_RS19765	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FK536_RS19770	COG1218	3'(2'),5'-bisphosphate nucleotidase
FK536_RS19780	COG1733	regulation of RNA biosynthetic process
FK536_RS19785	COG0702	epimerase
FK536_RS19790	COG0697	spore germination
FK536_RS19800	COG1113	amino acid transport
FK536_RS19805	COG0545	Peptidyl-prolyl cis-trans isomerase
FK536_RS19810	COG3061	Opacity-associated protein A
FK536_RS19815	COG1309	transcriptional regulator
FK536_RS19820	COG1028	Short-chain dehydrogenase reductase Sdr
FK536_RS19830	COG1024	Enoyl-CoA hydratase
FK536_RS19835	COG4670	ketone body catabolic process
FK536_RS19840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FK536_RS19845	COG2271	Major facilitator Superfamily
FK536_RS19855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FK536_RS19895	COG3414	Phosphotransferase system galactitol-specific IIB component
FK536_RS19900	COG3037	sugar-specific permease SgaT UlaA
FK536_RS19915	COG1073	alpha beta
FK536_RS19920	COG3650	response to hydrogen peroxide
FK536_RS19930	COG1960	acyl-CoA dehydrogenase activity
FK536_RS19935	COG0754	glutathionylspermidine amidase activity
FK536_RS19940	COG5463	Belongs to the UPF0441 family
FK536_RS19945	COG3766	membrane
FK536_RS19955	COG1842	Phage shock protein A
FK536_RS19960	COG3789	protein conserved in bacteria
FK536_RS19965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FK536_RS19970	COG0557	exoribonuclease II activity
FK536_RS19985	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FK536_RS19990	COG0330	HflC and HflK could
FK536_RS19995	COG0330	HflC and HflK could
FK536_RS20000	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FK536_RS20020	COG0860	N-Acetylmuramoyl-L-alanine amidase
FK536_RS20025	COG0802	atpase or kinase
FK536_RS20030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FK536_RS20030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FK536_RS20035	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FK536_RS20075	COG3264	Mechanosensitive ion channel
FK536_RS20075	COG1511	domain protein
FK536_RS20080	COG0531	amino acid
FK536_RS20090	COG1053	succinate dehydrogenase
FK536_RS20095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FK536_RS20110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FK536_RS20115	COG3040	lipid binding
FK536_RS20120	COG2076	Multidrug Resistance protein
FK536_RS20125	COG5510	response to toxic substance
FK536_RS20130	COG5510	response to toxic substance
FK536_RS20140	COG1509	lysine 2,3-aminomutase activity
FK536_RS20165	COG0531	amino acid
FK536_RS20170	COG3030	protein affecting phage T7 exclusion by the F plasmid
FK536_RS20175	COG1027	Aspartate ammonia-lyase
FK536_RS20180	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FK536_RS20195	COG1309	transcriptional regulator
FK536_RS20205	COG3710	Transcriptional regulator
FK536_RS20210	COG0531	amino acid
FK536_RS20215	COG1982	Orn Lys Arg decarboxylase major
FK536_RS20220	COG3104	oligopeptide transport
FK536_RS20225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FK536_RS20240	COG2388	GCN5-related N-acetyl-transferase
FK536_RS20245	COG3592	Divergent 4Fe-4S mono-cluster
FK536_RS20250	COG3290	protein histidine kinase activity
FK536_RS20255	COG4565	transcriptional regulatory protein
FK536_RS20260	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FK536_RS20265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FK536_RS20265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FK536_RS20270	COG3647	Membrane
FK536_RS20275	COG2211	Major facilitator Superfamily
FK536_RS20280	COG1486	melibiose metabolic process
FK536_RS20285	COG2169	Transcriptional regulator
FK536_RS20290	COG1982	Orn Lys Arg decarboxylase major
FK536_RS20295	COG2207	Transcriptional regulator
FK536_RS20300	COG0531	amino acid
FK536_RS20305	COG2194	sulfuric ester hydrolase activity
FK536_RS20310	COG0745	RESPONSE REGULATOR receiver
FK536_RS20315	COG0642	Histidine kinase
FK536_RS20325	COG0477	Major facilitator Superfamily
FK536_RS20335	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FK536_RS20340	COG2824	Alkylphosphonate utilization operon protein PhnA
FK536_RS20345	COG2764	glyoxalase bleomycin resistance protein dioxygenase
FK536_RS20350	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
FK536_RS20355	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
FK536_RS20360	COG3639	organic phosphonate transmembrane transporter activity
FK536_RS20365	COG2188	Transcriptional regulator
FK536_RS20370	COG3624	Phosphonate C-P lyase system protein PhnG
FK536_RS20375	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
FK536_RS20380	COG3626	phosphonate metabolism
FK536_RS20385	COG3627	carbon phosphorus lyase activity
FK536_RS20390	COG4107	phosphonate C-P lyase system protein PhnK
FK536_RS20395	COG4778	phosphonate C-P lyase system protein PhnL
FK536_RS20400	COG3454	Phosphonate metabolism
FK536_RS20405	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
FK536_RS20410	COG0456	acetyltransferase
FK536_RS20415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FK536_RS20425	COG0698	ribose 5-phosphate isomerase
FK536_RS20430	COG1737	Transcriptional regulator
FK536_RS20435	COG1879	ABC-type sugar transport system periplasmic component
FK536_RS20440	COG1129	ABC transporter
FK536_RS20445	COG1172	Belongs to the binding-protein-dependent transport system permease family
FK536_RS20450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FK536_RS20455	COG1940	carbohydrate kinase activity
FK536_RS20460	COG2015	COG2015, Alkyl sulfatase and related hydrolases
FK536_RS20470	COG1566	PFAM secretion protein HlyD family protein
FK536_RS20480	COG1538	Outer membrane efflux protein
FK536_RS20490	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FK536_RS20495	COG1301	dicarboxylic acid transport
FK536_RS20500	COG4235	cytochrome complex assembly
FK536_RS20505	COG3088	subunit of a heme lyase
FK536_RS20510	COG1138	Cytochrome C-type biogenesis protein
FK536_RS20515	COG3301	Polysulphide reductase, NrfD
FK536_RS20520	COG0437	4 iron, 4 sulfur cluster binding
FK536_RS20525	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FK536_RS20535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FK536_RS20540	COG3162	membrane
FK536_RS20550	COG1357	PFAM Pentapeptide repeats (8 copies)
FK536_RS20555	COG0025	NhaP-type Na H and K H
FK536_RS20560	COG2252	PERMEase
FK536_RS20565	COG0789	Transcriptional regulator
FK536_RS20570	COG2207	Transcriptional regulator
FK536_RS20585	COG0629	single-stranded DNA binding
FK536_RS20590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FK536_RS20595	COG2315	Protein conserved in bacteria
FK536_RS20600	COG0432	Pfam Uncharacterised protein family UPF0047
FK536_RS20605	COG3700	Belongs to the class B bacterial acid phosphatase family
FK536_RS20615	COG1448	Aminotransferase
FK536_RS20620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FK536_RS20625	COG0305	Participates in initiation and elongation during chromosome replication
FK536_RS20630	COG0604	alcohol dehydrogenase
FK536_RS20640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FK536_RS20650	COG0735	belongs to the Fur family
FK536_RS20655	COG3237	CsbD-like
FK536_RS20660	COG0534	Mate efflux family protein
FK536_RS20670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FK536_RS20705	COG3842	ATPase activity
FK536_RS20710	COG2182	Extracellular solute-binding protein
FK536_RS20715	COG1175	transmembrane transport
FK536_RS20720	COG3833	ABC-type maltose transport systems, permease component
FK536_RS20725	COG2814	Major facilitator Superfamily
FK536_RS20725	COG0477	Major facilitator Superfamily
FK536_RS20745	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FK536_RS20770	COG0527	aspartate kinase activity
FK536_RS20780	COG1187	pseudouridine synthase activity
FK536_RS20830	COG1283	sodium-dependent phosphate transmembrane transporter activity
FK536_RS20835	COG0646	methionine synthase
FK536_RS20835	COG1410	methionine synthase
FK536_RS20840	COG1414	Transcriptional regulator
FK536_RS20855	COG2224	Isocitrate lyase
FK536_RS20860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FK536_RS20870	COG0456	acetyltransferase
FK536_RS20900	COG0151	Belongs to the GarS family
FK536_RS20905	COG2204	response regulator
FK536_RS20910	COG4191	Histidine kinase
FK536_RS20915	COG3678	ATP-independent chaperone mediated protein folding
FK536_RS20930	COG3068	Protein conserved in bacteria
FK536_RS20965	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FK536_RS20970	COG2104	thiamine diphosphate biosynthetic process
FK536_RS20980	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FK536_RS21020	COG0250	Participates in transcription elongation, termination and antitermination
FK536_RS21025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FK536_RS21060	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FK536_RS21060	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FK536_RS21065	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FK536_RS21090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FK536_RS21095	COG4206	TonB-dependent receptor
FK536_RS21110	COG1309	transcriptional regulator
FK536_RS21120	COG0583	DNA-binding transcription factor activity
FK536_RS21135	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FK536_RS21160	COG2194	sulfuric ester hydrolase activity
FK536_RS21165	COG2207	Transcriptional regulator
FK536_RS21170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS21175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FK536_RS21180	COG1882	Formate acetyltransferase
FK536_RS21185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS21190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS21195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS21195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS21195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FK536_RS21200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FK536_RS21205	COG0371	Dehydrogenase
FK536_RS21210	COG3738	Protein conserved in bacteria
FK536_RS21215	COG0697	spore germination
FK536_RS21225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FK536_RS21230	COG0460	homoserine dehydrogenase
FK536_RS21230	COG0527	aspartate kinase activity
FK536_RS21235	COG0626	cystathionine gamma-synthase activity
FK536_RS21245	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
FK536_RS21260	COG3209	COG3209 Rhs family protein
FK536_RS21270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FK536_RS21275	COG1609	Transcriptional regulator
FK536_RS21280	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FK536_RS21295	COG1575	Belongs to the MenA family. Type 1 subfamily
FK536_RS21310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FK536_RS21320	COG1494	fructose-1,6-bisphosphatase
FK536_RS21325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FK536_RS21330	COG0589	response to stress
FK536_RS21335	COG3691	Protein conserved in bacteria
FK536_RS21340	COG3152	Membrane
FK536_RS21360	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FK536_RS21375	COG3678	ATP-independent chaperone mediated protein folding
FK536_RS21380	COG0745	RESPONSE REGULATOR receiver
FK536_RS21385	COG2205	protein histidine kinase activity
FK536_RS21390	COG2258	MOSC domain
FK536_RS21400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FK536_RS21410	COG4977	sequence-specific DNA binding
FK536_RS21410	COG1917	Cupin 2, conserved barrel domain protein
FK536_RS21440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS21445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS21445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FK536_RS21450	COG1363	Peptidase, m42
FK536_RS21455	COG3711	transcriptional antiterminator
FK536_RS21455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FK536_RS21475	COG0437	4 iron, 4 sulfur cluster binding
FK536_RS21480	COG2864	formate dehydrogenase
FK536_RS21490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FK536_RS21495	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
FK536_RS21505	COG0456	acetyltransferase
FK536_RS21520	COG1011	Hydrolase
FK536_RS21525	COG1349	DNA-binding transcription factor activity
FK536_RS21530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK536_RS21535	COG2084	Dehydrogenase
FK536_RS21540	COG3684	Belongs to the aldolase LacD family
FK536_RS21560	COG2188	Transcriptional regulator
FK536_RS21570	COG0174	glutamine synthetase
FK536_RS21575	COG3852	Histidine kinase
FK536_RS21580	COG2204	response regulator
FK536_RS21590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FK536_RS21605	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FK536_RS21605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FK536_RS21610	COG0204	Acyl-transferase
FK536_RS21615	COG5339	Protein conserved in bacteria
FK536_RS21620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FK536_RS21625	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FK536_RS21630	COG3084	Protein conserved in bacteria
FK536_RS21635	COG0746	molybdenum cofactor guanylyltransferase activity
FK536_RS21640	COG1763	Mo-molybdopterin cofactor biosynthetic process
FK536_RS21670	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
FK536_RS21675	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FK536_RS21680	COG1739	Uncharacterized protein family UPF0029
FK536_RS21695	COG0183	Belongs to the thiolase family
FK536_RS21700	COG0543	2 iron, 2 sulfur cluster binding
FK536_RS21710	COG0250	Participates in transcription elongation, termination and antitermination
FK536_RS21715	COG0084	hydrolase, TatD family'
FK536_RS21720	COG0805	protein transport
FK536_RS21725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FK536_RS21730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FK536_RS21740	COG3165	ubiquinone biosynthetic process from chorismate
FK536_RS21750	COG1322	Protein conserved in bacteria
FK536_RS21755	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FK536_RS21760	COG0412	Dienelactone hydrolase
FK536_RS21770	COG0583	DNA-binding transcription factor activity
FK536_RS21775	COG0697	spore germination
FK536_RS21780	COG0561	phosphatase activity
FK536_RS21785	COG2267	carboxylic ester hydrolase activity
FK536_RS21790	COG1280	lysine exporter protein (LysE YggA)
FK536_RS21795	COG1280	lysine exporter protein (LysE YggA)
FK536_RS21800	COG0514	ATP-dependent DNA helicase (RecQ)
FK536_RS21805	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FK536_RS21810	COG2050	protein possibly involved in aromatic compounds catabolism
FK536_RS21815	COG2962	Rard protein
FK536_RS21830	COG0598	Magnesium transport protein CorA
FK536_RS21835	COG3698	Phosphodiester glycosidase
FK536_RS21840	COG0210	DNA helicase
FK536_RS21845	COG1011	Hydrolase
FK536_RS21855	COG3159	Protein conserved in bacteria
FK536_RS21865	COG5567	small periplasmic lipoprotein
FK536_RS21875	COG3072	Adenylate cyclase
FK536_RS21885	COG1587	Uroporphyrinogen-III synthase
FK536_RS21890	COG2959	enzyme of heme biosynthesis
FK536_RS21895	COG3071	HemY protein
FK536_RS21905	COG3119	arylsulfatase activity
FK536_RS21910	COG0641	radical SAM
FK536_RS21935	COG1113	amino acid transport
FK536_RS21955	COG2244	polysaccharide biosynthetic process
FK536_RS21960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FK536_RS21965	COG0456	acetyltransferase
FK536_RS21970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FK536_RS21975	COG1088	dTDP-glucose 4,6-dehydratase activity
FK536_RS21980	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FK536_RS21985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FK536_RS21990	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
FK536_RS21995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FK536_RS22000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FK536_RS22010	COG3118	belongs to the thioredoxin family
FK536_RS22025	COG0210	DNA helicase
FK536_RS22030	COG3692	DNA binding
FK536_RS22035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FK536_RS22045	COG0583	DNA-binding transcription factor activity
FK536_RS22050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FK536_RS22060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FK536_RS22065	COG3978	acetolactate synthase activity
FK536_RS22085	COG0606	chelatase, subunit chli
FK536_RS22090	COG0606	chelatase, subunit chli
FK536_RS22095	COG3085	chromosome segregation
FK536_RS22135	COG2186	Transcriptional regulator
FK536_RS22140	COG0477	Major facilitator Superfamily
FK536_RS22145	COG1609	Transcriptional regulator
FK536_RS22150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FK536_RS22155	COG1879	ABC-type sugar transport system periplasmic component
FK536_RS22160	COG1172	Belongs to the binding-protein-dependent transport system permease family
FK536_RS22165	COG1129	ABC transporter
FK536_RS22195	COG1522	sequence-specific DNA binding
FK536_RS22200	COG0716	FMN binding
FK536_RS22215	COG3312	ion transport
FK536_RS22265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FK536_RS22270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FK536_RS22275	COG0573	inorganic phosphate transmembrane transporter activity
FK536_RS22280	COG0581	inorganic phosphate transmembrane transporter activity
FK536_RS22285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FK536_RS22290	COG0704	Plays a role in the regulation of phosphate uptake
FK536_RS22295	COG3711	transcriptional antiterminator
FK536_RS22300	COG2190	(PTS) system
FK536_RS22300	COG1263	PTS System
FK536_RS22300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FK536_RS22305	COG2723	6-phospho-beta-galactosidase activity
FK536_RS22315	COG2382	esterase
FK536_RS22320	COG0363	glucosamine-6-phosphate deaminase activity
FK536_RS22325	COG3196	Protein conserved in bacteria
FK536_RS22335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FK536_RS22340	COG2252	PERMEase
FK536_RS22345	COG0431	NADPH-dependent FMN reductase
FK536_RS22350	COG2091	lysine biosynthetic process via aminoadipic acid
FK536_RS22365	COG0814	amino acid
FK536_RS22420	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
FK536_RS22540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FK536_RS22590	COG0697	spore germination
FK536_RS22610	COG4644	lycopene metabolic process
FK536_RS22645	COG1846	Transcriptional regulator
FK536_RS22745	COG4221	oxidoreductase activity
FK536_RS22820	COG1192	Involved in chromosome partitioning
FK536_RS22855	COG2026	Addiction module toxin, RelE StbE family
FK536_RS22905	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FK536_RS22945	COG3706	GGDEF domain
FK536_RS22965	COG2826	transposase and inactivated derivatives, IS30 family
FK536_RS22985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FK536_RS22995	COG3436	PFAM IS66 Orf2 family protein