locus-tag	class	description
BFL16_RS00010	COG0460	homoserine dehydrogenase
BFL16_RS00010	COG0527	aspartate kinase activity
BFL16_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BFL16_RS00040	COG1115	amino acid carrier protein
BFL16_RS00045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BFL16_RS00050	COG0521	Mo-molybdopterin cofactor biosynthetic process
BFL16_RS00055	COG1584	GPR1 FUN34 yaaH family protein
BFL16_RS00060	COG4735	regulation of single-species biofilm formation
BFL16_RS00090	COG0583	DNA-binding transcription factor activity
BFL16_RS00105	COG3188	usher protein
BFL16_RS00110	COG3121	Chaperone
BFL16_RS00135	COG0196	riboflavin kinase activity
BFL16_RS00150	COG1047	Peptidyl-prolyl cis-trans
BFL16_RS00170	COG0505	Belongs to the CarA family
BFL16_RS00175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BFL16_RS00195	COG1024	Enoyl-CoA hydratase
BFL16_RS00230	COG0644	oxidoreductase
BFL16_RS00235	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BFL16_RS00240	COG2271	Major facilitator Superfamily
BFL16_RS00255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BFL16_RS00290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFL16_RS00295	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BFL16_RS00300	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BFL16_RS00305	COG1357	PFAM Pentapeptide repeats (8 copies)
BFL16_RS00320	COG0564	pseudouridine synthase activity
BFL16_RS00330	COG0417	DNA replication proofreading
BFL16_RS00335	COG0235	Class ii aldolase
BFL16_RS00360	COG4977	sequence-specific DNA binding
BFL16_RS00365	COG0586	Pfam SNARE associated Golgi protein
BFL16_RS00370	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BFL16_RS00375	COG1178	ABC-type Fe3 transport system permease component
BFL16_RS00380	COG4143	(ABC) transporter
BFL16_RS00390	COG4533	DNA binding
BFL16_RS00410	COG0473	3-isopropylmalate dehydrogenase activity
BFL16_RS00425	COG0583	DNA-binding transcription factor activity
BFL16_RS00430	COG0028	Belongs to the TPP enzyme family
BFL16_RS00435	COG0440	acetolactate synthase activity
BFL16_RS00445	COG1609	Transcriptional regulator
BFL16_RS00465	COG3116	cell division
BFL16_RS00470	COG0768	penicillin binding
BFL16_RS00475	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BFL16_RS00480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BFL16_RS00490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BFL16_RS00495	COG0772	Belongs to the SEDS family
BFL16_RS00510	COG1181	Belongs to the D-alanine--D-alanine ligase family
BFL16_RS00515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BFL16_RS00520	COG0849	cell division
BFL16_RS00525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BFL16_RS00545	COG0494	nUDIX hydrolase
BFL16_RS00560	COG0237	dephospho-CoA kinase activity
BFL16_RS00570	COG1459	type II secretion system
BFL16_RS00575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BFL16_RS00580	COG4969	Belongs to the N-Me-Phe pilin family
BFL16_RS00590	COG0157	Belongs to the NadC ModD family
BFL16_RS00595	COG3023	N-Acetylmuramoyl-L-alanine amidase
BFL16_RS00600	COG3725	Membrane protein required for beta-lactamase induction
BFL16_RS00605	COG1113	amino acid transport
BFL16_RS00610	COG2186	Transcriptional regulator
BFL16_RS00620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BFL16_RS00625	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFL16_RS00630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFL16_RS00635	COG3064	Membrane
BFL16_RS00645	COG1049	propionate catabolic process, 2-methylcitrate cycle
BFL16_RS00670	COG2132	Multicopper oxidase
BFL16_RS00675	COG4993	Dehydrogenase
BFL16_RS00680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BFL16_RS00685	COG0288	reversible hydration of carbon dioxide
BFL16_RS00690	COG1131	(ABC) transporter
BFL16_RS00695	COG0842	Transport permease protein
BFL16_RS00700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS00705	COG0726	polysaccharide deacetylase
BFL16_RS00725	COG5464	transposase or invertase
BFL16_RS00755	COG3539	Fimbrial protein
BFL16_RS00760	COG3539	Fimbrial protein
BFL16_RS00765	COG3188	usher protein
BFL16_RS00770	COG3121	Chaperone
BFL16_RS00780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BFL16_RS00785	COG0617	tRNA 3'-terminal CCA addition
BFL16_RS00790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BFL16_RS00795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BFL16_RS00805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BFL16_RS00810	COG1643	Atp-dependent helicase
BFL16_RS00820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BFL16_RS00825	COG4774	siderophore transport
BFL16_RS00830	COG1120	ATPase activity
BFL16_RS00835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BFL16_RS00840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFL16_RS00860	COG2860	membrane
BFL16_RS00865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BFL16_RS00885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFL16_RS00890	COG3835	regulator
BFL16_RS00915	COG0024	Methionine aminopeptidase
BFL16_RS00950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BFL16_RS00955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BFL16_RS00960	COG0575	Belongs to the CDS family
BFL16_RS00965	COG0750	zinc metalloprotease
BFL16_RS00975	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
BFL16_RS00980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFL16_RS01005	COG0587	DNA-directed DNA polymerase activity
BFL16_RS01015	COG1982	Orn Lys Arg decarboxylase major
BFL16_RS01020	COG0346	lactoylglutathione lyase activity
BFL16_RS01025	COG0037	tRNA processing
BFL16_RS01030	COG4568	rho-dependent transcription termination
BFL16_RS01040	COG4681	YaeQ
BFL16_RS01045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BFL16_RS01050	COG3015	lipoprotein NlpE involved in copper resistance
BFL16_RS01055	COG0791	NLP P60 protein
BFL16_RS01065	COG1720	tRNA m6t6A37 methyltransferase activity
BFL16_RS01075	COG1464	Belongs to the NlpA lipoprotein family
BFL16_RS01080	COG2011	ABC-type metal ion transport system permease component
BFL16_RS01085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BFL16_RS01090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BFL16_RS01125	COG0656	L-ascorbic acid biosynthetic process
BFL16_RS01130	COG0583	DNA-binding transcription factor activity
BFL16_RS01140	COG2226	methyltransferase
BFL16_RS01145	COG1388	LysM domain
BFL16_RS01145	COG0741	lytic transglycosylase activity
BFL16_RS01155	COG2226	methyltransferase
BFL16_RS01165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFL16_RS01305	COG3209	COG3209 Rhs family protein
BFL16_RS01325	COG3209	COG3209 Rhs family protein
BFL16_RS01345	COG5433	transposase activity
BFL16_RS01350	COG3209	COG3209 Rhs family protein
BFL16_RS01365	COG5433	transposase activity
BFL16_RS01370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BFL16_RS01380	COG1960	acyl-CoA dehydrogenase activity
BFL16_RS01390	COG0121	glutamine amidotransferase
BFL16_RS01395	COG3034	peptidoglycan biosynthetic process
BFL16_RS01400	COG3041	Addiction module toxin RelE StbE family
BFL16_RS01405	COG3077	Addiction module antitoxin, RelB DinJ family
BFL16_RS01410	COG0791	NLP P60 protein
BFL16_RS01420	COG1943	Transposase
BFL16_RS01440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BFL16_RS01445	COG2161	toxin-antitoxin pair type II binding
BFL16_RS01455	COG0454	-acetyltransferase
BFL16_RS01460	COG1690	Belongs to the RtcB family
BFL16_RS01465	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BFL16_RS01470	COG2195	Cleaves the N-terminal amino acid of tripeptides
BFL16_RS01490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BFL16_RS01510	COG0582	viral genome integration into host DNA
BFL16_RS01585	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BFL16_RS01595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BFL16_RS01615	COG0582	viral genome integration into host DNA
BFL16_RS01700	COG0583	DNA-binding transcription factor activity
BFL16_RS01705	COG4221	oxidoreductase activity
BFL16_RS01715	COG0583	DNA-binding transcription factor activity
BFL16_RS01730	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BFL16_RS01735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BFL16_RS01740	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BFL16_RS01745	COG2080	2 iron, 2 sulfur cluster binding
BFL16_RS01755	COG3477	response to acidic pH
BFL16_RS01765	COG0727	PFAM Uncharacterised protein family (UPF0153)
BFL16_RS01770	COG3121	Chaperone
BFL16_RS01780	COG3188	usher protein
BFL16_RS01830	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS01835	COG4372	Transposase
BFL16_RS01845	COG1902	pentaerythritol trinitrate reductase activity
BFL16_RS01850	COG1073	alpha beta
BFL16_RS01855	COG0583	DNA-binding transcription factor activity
BFL16_RS01865	COG0656	L-ascorbic acid biosynthetic process
BFL16_RS01870	COG1388	LysM domain
BFL16_RS01875	COG3708	Transcriptional regulator
BFL16_RS01875	COG2207	Transcriptional regulator
BFL16_RS01880	COG0656	L-ascorbic acid biosynthetic process
BFL16_RS01885	COG3059	membrane
BFL16_RS01895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFL16_RS01900	COG2207	Transcriptional regulator
BFL16_RS01905	COG0247	lactate metabolic process
BFL16_RS01910	COG1139	Iron-sulfur cluster binding protein
BFL16_RS01915	COG1556	Lactate utilization protein
BFL16_RS01950	COG2200	EAL domain
BFL16_RS01950	COG2771	luxR family
BFL16_RS01985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BFL16_RS01995	COG2771	luxR family
BFL16_RS01995	COG2200	EAL domain
BFL16_RS02015	COG0666	response to abiotic stimulus
BFL16_RS02025	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BFL16_RS02030	COG1304	FMN binding
BFL16_RS02040	COG0549	Belongs to the carbamate kinase family
BFL16_RS02045	COG0402	S-adenosylhomocysteine deaminase activity
BFL16_RS02055	COG1879	ABC-type sugar transport system periplasmic component
BFL16_RS02060	COG1129	ABC transporter
BFL16_RS02065	COG1129	ABC transporter
BFL16_RS02070	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS02080	COG1064	alcohol dehydrogenase
BFL16_RS02095	COG1280	lysine exporter protein (LysE YggA)
BFL16_RS02105	COG3829	transcription factor binding
BFL16_RS02110	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BFL16_RS02115	COG0372	Belongs to the citrate synthase family
BFL16_RS02120	COG2079	MmgE PrpD family protein
BFL16_RS02125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFL16_RS02140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BFL16_RS02145	COG0402	S-adenosylhomocysteine deaminase activity
BFL16_RS02150	COG0583	DNA-binding transcription factor activity
BFL16_RS02155	COG0288	reversible hydration of carbon dioxide
BFL16_RS02165	COG2807	transmembrane transport
BFL16_RS02170	COG0110	maltose O-acetyltransferase activity
BFL16_RS02175	COG2223	nitrite transmembrane transporter activity
BFL16_RS02180	COG3250	beta-galactosidase activity
BFL16_RS02190	COG1609	Transcriptional regulator
BFL16_RS02200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BFL16_RS02205	COG1414	Transcriptional regulator
BFL16_RS02220	COG0596	Alpha beta hydrolase
BFL16_RS02235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFL16_RS02240	COG2814	Major facilitator Superfamily
BFL16_RS02245	COG3122	Protein conserved in bacteria
BFL16_RS02250	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BFL16_RS02265	COG3842	ATPase activity
BFL16_RS02275	COG1840	ABC-type Fe3 transport system, periplasmic component
BFL16_RS02280	COG2271	Major facilitator Superfamily
BFL16_RS02295	COG4521	taurine ABC transporter
BFL16_RS02300	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BFL16_RS02305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFL16_RS02310	COG2175	clavaminate synthase activity
BFL16_RS02315	COG0113	porphobilinogen synthase activity
BFL16_RS02320	COG3468	outer membrane autotransporter barrel domain protein
BFL16_RS02325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFL16_RS02330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BFL16_RS02340	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
BFL16_RS02360	COG1181	Belongs to the D-alanine--D-alanine ligase family
BFL16_RS02375	COG1785	Belongs to the alkaline phosphatase family
BFL16_RS02385	COG3706	GGDEF domain
BFL16_RS02390	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BFL16_RS02415	COG4126	flavin adenine dinucleotide binding
BFL16_RS02445	COG1940	carbohydrate kinase activity
BFL16_RS02450	COG2814	Major facilitator Superfamily
BFL16_RS02455	COG0419	ATPase involved in DNA repair
BFL16_RS02460	COG0420	3'-5' exonuclease activity
BFL16_RS02465	COG0745	RESPONSE REGULATOR receiver
BFL16_RS02470	COG5002	protein histidine kinase activity
BFL16_RS02475	COG1114	Component of the transport system for branched-chain amino acids
BFL16_RS02480	COG1113	amino acid transport
BFL16_RS02485	COG0366	Alpha amylase catalytic
BFL16_RS02510	COG1862	Preprotein translocase
BFL16_RS02515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BFL16_RS02520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BFL16_RS02525	COG3609	addiction module antidote protein, CC2985 family
BFL16_RS02535	COG1403	HNH endonuclease
BFL16_RS02540	COG3248	Nucleoside-binding outer membrane protein
BFL16_RS02545	COG4238	major outer membrane lipoprotein
BFL16_RS02555	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFL16_RS02555	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFL16_RS02570	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BFL16_RS02575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BFL16_RS02585	COG0667	Aldo Keto reductase
BFL16_RS02595	COG0142	geranyltranstransferase activity
BFL16_RS02610	COG0693	protein deglycase activity
BFL16_RS02615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BFL16_RS02625	COG2814	Major facilitator Superfamily
BFL16_RS02635	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BFL16_RS02640	COG1845	cytochrome c oxidase, subunit III
BFL16_RS02645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFL16_RS02650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BFL16_RS02655	COG2223	nitrite transmembrane transporter activity
BFL16_RS02660	COG3056	Lipoprotein
BFL16_RS02670	COG0271	Belongs to the BolA IbaG family
BFL16_RS02695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BFL16_RS02700	COG0776	regulation of translation
BFL16_RS02705	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFL16_RS02710	COG1555	photosystem II stabilization
BFL16_RS02715	COG0824	Thioesterase
BFL16_RS02725	COG4533	DNA binding
BFL16_RS02735	COG1522	sequence-specific DNA binding
BFL16_RS02740	COG1132	(ABC) transporter
BFL16_RS02745	COG1132	(ABC) transporter
BFL16_RS02750	COG0347	Belongs to the P(II) protein family
BFL16_RS02755	COG0004	ammonium transporteR
BFL16_RS02760	COG1946	Acyl-CoA thioesterase
BFL16_RS02765	COG3126	Type III secretion system lipoprotein chaperone (YscW)
BFL16_RS02770	COG3695	enzyme binding
BFL16_RS02780	COG5507	3-demethylubiquinone-9 3-methyltransferase
BFL16_RS02785	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BFL16_RS02795	COG0110	maltose O-acetyltransferase activity
BFL16_RS02810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFL16_RS02815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL16_RS02820	COG1309	transcriptional regulator
BFL16_RS02830	COG1196	nuclear chromosome segregation
BFL16_RS02830	COG3264	Mechanosensitive ion channel
BFL16_RS02840	COG3923	Primosomal replication protein n
BFL16_RS02845	COG2832	Protein of unknown function (DUF454)
BFL16_RS02860	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BFL16_RS02895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL16_RS02905	COG4651	solute:proton antiporter activity
BFL16_RS02905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BFL16_RS02910	COG2223	nitrite transmembrane transporter activity
BFL16_RS02920	COG0737	Belongs to the 5'-nucleotidase family
BFL16_RS02925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BFL16_RS02930	COG3735	TraB family
BFL16_RS02935	COG3093	addiction module antidote protein HigA
BFL16_RS02950	COG2217	Heavy metal translocating P-type atpase
BFL16_RS02955	COG2066	Belongs to the glutaminase family
BFL16_RS02960	COG0531	amino acid
BFL16_RS02990	COG0789	Transcriptional regulator
BFL16_RS03015	COG1585	Membrane protein implicated in regulation of membrane protease activity
BFL16_RS03020	COG0330	HflC and HflK could
BFL16_RS03025	COG4619	ABC transporter
BFL16_RS03030	COG0390	transport system, permease component
BFL16_RS03035	COG3118	belongs to the thioredoxin family
BFL16_RS03040	COG0300	oxidoreductase activity
BFL16_RS03045	COG2755	lipolytic protein G-D-S-L family
BFL16_RS03050	COG4181	ATPase activity
BFL16_RS03055	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BFL16_RS03060	COG3209	COG3209 Rhs family protein
BFL16_RS03070	COG2801	Transposase and inactivated derivatives
BFL16_RS03080	COG0583	DNA-binding transcription factor activity
BFL16_RS03090	COG1414	Transcriptional regulator
BFL16_RS03095	COG3960	tartronate-semialdehyde synthase activity
BFL16_RS03100	COG3622	Belongs to the hyi family
BFL16_RS03105	COG2084	Dehydrogenase
BFL16_RS03110	COG1953	Uracil, thiamine, allantoin
BFL16_RS03125	COG2233	PERMEase
BFL16_RS03130	COG1929	Belongs to the glycerate kinase type-1 family
BFL16_RS03135	COG3257	ureidoglycine aminohydrolase activity
BFL16_RS03140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFL16_RS03145	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BFL16_RS03150	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BFL16_RS03155	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BFL16_RS03165	COG0549	Belongs to the carbamate kinase family
BFL16_RS03170	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BFL16_RS03175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BFL16_RS03190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BFL16_RS03200	COG1988	membrane-bound metal-dependent
BFL16_RS03205	COG2501	S4 domain
BFL16_RS03215	COG3539	Fimbrial protein
BFL16_RS03220	COG3121	Chaperone
BFL16_RS03225	COG3188	usher protein
BFL16_RS03230	COG3539	Fimbrial protein
BFL16_RS03235	COG3539	Fimbrial protein
BFL16_RS03240	COG2197	response regulator
BFL16_RS03250	COG2207	Transcriptional regulator
BFL16_RS03265	COG4783	chaperone-mediated protein folding
BFL16_RS03270	COG1215	transferase activity, transferring glycosyl groups
BFL16_RS03275	COG5433	transposase activity
BFL16_RS03285	COG4104	PAAR repeat-containing protein
BFL16_RS03285	COG3209	COG3209 Rhs family protein
BFL16_RS03295	COG4104	PAAR repeat-containing protein
BFL16_RS03295	COG3209	COG3209 Rhs family protein
BFL16_RS03310	COG5002	protein histidine kinase activity
BFL16_RS03315	COG0745	RESPONSE REGULATOR receiver
BFL16_RS03325	COG1538	Outer membrane efflux protein
BFL16_RS03330	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL16_RS03335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL16_RS03340	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFL16_RS03345	COG1113	amino acid transport
BFL16_RS03350	COG0668	transmembrane transport
BFL16_RS03355	COG0778	Nitroreductase
BFL16_RS03360	COG2315	Protein conserved in bacteria
BFL16_RS03400	COG2977	Belongs to the P-Pant transferase superfamily
BFL16_RS03410	COG4771	TonB-dependent receptor
BFL16_RS03415	COG2382	esterase
BFL16_RS03420	COG3251	PFAM MbtH domain protein
BFL16_RS03425	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BFL16_RS03425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BFL16_RS03430	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BFL16_RS03435	COG1120	ATPase activity
BFL16_RS03440	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFL16_RS03445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFL16_RS03455	COG4592	Periplasmic binding protein
BFL16_RS03460	COG1169	isochorismate synthase
BFL16_RS03465	COG1021	2,3-dihydroxybenzoate-AMP ligase
BFL16_RS03470	COG3433	isochorismatase activity
BFL16_RS03470	COG1535	isochorismatase
BFL16_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS03485	COG1966	Carbon starvation protein
BFL16_RS03490	COG2879	small protein
BFL16_RS03495	COG0371	Dehydrogenase
BFL16_RS03500	COG0436	Aminotransferase
BFL16_RS03505	COG1475	DNA binding
BFL16_RS03510	COG3969	phosphoadenosine phosphosulfate
BFL16_RS03515	COG0583	DNA-binding transcription factor activity
BFL16_RS03520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BFL16_RS03525	COG0450	alkyl hydroperoxide reductase
BFL16_RS03535	COG3634	alkyl hydroperoxide reductase activity
BFL16_RS03540	COG0589	response to stress
BFL16_RS03545	COG1063	alcohol dehydrogenase
BFL16_RS03555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BFL16_RS03565	COG3719	Belongs to the RNase T2 family
BFL16_RS03570	COG0471	metal ion transport
BFL16_RS03575	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
BFL16_RS03585	COG3051	citrate lyase alpha subunit
BFL16_RS03590	COG2301	Belongs to the HpcH HpaI aldolase family
BFL16_RS03600	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
BFL16_RS03605	COG3290	protein histidine kinase activity
BFL16_RS03610	COG4565	transcriptional regulatory protein
BFL16_RS03615	COG3069	C4-dicarboxylate transmembrane transporter activity
BFL16_RS03640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BFL16_RS03645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFL16_RS03660	COG0583	DNA-binding transcription factor activity
BFL16_RS03680	COG1686	Belongs to the peptidase S11 family
BFL16_RS03685	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BFL16_RS03690	COG0772	Belongs to the SEDS family
BFL16_RS03695	COG0768	penicillin binding
BFL16_RS03705	COG0799	negative regulation of ribosome biogenesis
BFL16_RS03710	COG0406	alpha-ribazole phosphatase activity
BFL16_RS03720	COG1466	dna polymerase III delta subunit
BFL16_RS03735	COG2888	peptidyl-tyrosine sulfation
BFL16_RS03750	COG2214	Heat shock protein DnaJ domain protein
BFL16_RS03755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BFL16_RS03765	COG2214	Heat shock protein DnaJ domain protein
BFL16_RS03770	COG2214	Heat shock protein DnaJ domain protein
BFL16_RS03775	COG0443	Heat shock 70 kDa protein
BFL16_RS03785	COG1126	abc transporter atp-binding protein
BFL16_RS03790	COG0765	amino acid transport
BFL16_RS03795	COG0765	amino acid transport
BFL16_RS03800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL16_RS03805	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BFL16_RS03810	COG4535	Mg2 and Co2 transporter CorC
BFL16_RS03820	COG1702	phosphate starvation-inducible protein PhoH
BFL16_RS03830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFL16_RS03880	COG0367	asparagine synthase
BFL16_RS03885	COG0647	UMP catabolic process
BFL16_RS03890	COG1846	Transcriptional regulator
BFL16_RS03890	COG1940	carbohydrate kinase activity
BFL16_RS03895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BFL16_RS03905	COG2190	(PTS) system
BFL16_RS03905	COG1263	PTS System
BFL16_RS03905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFL16_RS03925	COG0735	belongs to the Fur family
BFL16_RS03940	COG0716	FMN binding
BFL16_RS03950	COG0596	Alpha beta hydrolase
BFL16_RS03955	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
BFL16_RS03960	COG0033	Phosphoglucomutase
BFL16_RS03965	COG0531	amino acid
BFL16_RS03970	COG1982	Orn Lys Arg decarboxylase major
BFL16_RS03985	COG0745	RESPONSE REGULATOR receiver
BFL16_RS03990	COG2205	protein histidine kinase activity
BFL16_RS04020	COG3209	COG3209 Rhs family protein
BFL16_RS04045	COG5433	transposase activity
BFL16_RS04050	COG3272	Protein of unknown function (DUF1722)
BFL16_RS04055	COG0415	Belongs to the DNA photolyase family
BFL16_RS04060	COG3104	oligopeptide transport
BFL16_RS04065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BFL16_RS04070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BFL16_RS04075	COG1984	allophanate hydrolase subunit 2
BFL16_RS04085	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BFL16_RS04090	COG3180	Ammonia monooxygenase
BFL16_RS04095	COG3539	Fimbrial protein
BFL16_RS04100	COG3121	Chaperone
BFL16_RS04105	COG3188	usher protein
BFL16_RS04110	COG3539	Fimbrial protein
BFL16_RS04115	COG0372	Belongs to the citrate synthase family
BFL16_RS04135	COG2009	succinate dehydrogenase
BFL16_RS04140	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BFL16_RS04145	COG1053	succinate dehydrogenase
BFL16_RS04150	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BFL16_RS04160	COG0567	Dehydrogenase, E1 component
BFL16_RS04165	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFL16_RS04175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BFL16_RS04190	COG0583	DNA-binding transcription factor activity
BFL16_RS04195	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BFL16_RS04200	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BFL16_RS04200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BFL16_RS04205	COG1301	dicarboxylic acid transport
BFL16_RS04220	COG3799	methylaspartate ammonia-lyase activity
BFL16_RS04225	COG4865	methylaspartate mutase activity
BFL16_RS04235	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFL16_RS04255	COG1271	oxidase subunit
BFL16_RS04260	COG1294	oxidase, subunit
BFL16_RS04265	COG4890	Cyd operon protein YbgT
BFL16_RS04270	COG3790	cyd operon protein YbgE
BFL16_RS04275	COG0824	Thioesterase
BFL16_RS04280	COG0811	peptide transport
BFL16_RS04285	COG0848	biopolymer transport protein
BFL16_RS04290	COG3064	Membrane
BFL16_RS04300	COG2885	chlorophyll binding
BFL16_RS04305	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
BFL16_RS04340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BFL16_RS04345	COG3201	nicotinamide mononucleotide transporter
BFL16_RS04350	COG1230	cation diffusion facilitator family transporter
BFL16_RS04365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BFL16_RS04375	COG2017	converts alpha-aldose to the beta-anomer
BFL16_RS04385	COG1085	galactose-1-phosphate uridylyltransferase
BFL16_RS04390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BFL16_RS04395	COG1119	ATPase activity
BFL16_RS04400	COG2005	Transcriptional regulator
BFL16_RS04400	COG3585	molybdate ion transport
BFL16_RS04415	COG0725	ABC transporter, periplasmic molybdate-binding protein
BFL16_RS04420	COG4149	molybdate abc transporter
BFL16_RS04430	COG0561	phosphatase activity
BFL16_RS04440	COG0583	DNA-binding transcription factor activity
BFL16_RS04445	COG2828	Protein conserved in bacteria
BFL16_RS04465	COG0471	metal ion transport
BFL16_RS04470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BFL16_RS04475	COG4677	pectinesterase activity
BFL16_RS04595	COG3772	lysozyme
BFL16_RS04640	COG0740	serine-type endopeptidase activity
BFL16_RS04715	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS04735	COG0727	PFAM Uncharacterised protein family (UPF0153)
BFL16_RS04760	COG1881	PFAM PEBP family protein
BFL16_RS04765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BFL16_RS04780	COG2226	methyltransferase
BFL16_RS04785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BFL16_RS04795	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BFL16_RS04805	COG0521	Mo-molybdopterin cofactor biosynthetic process
BFL16_RS04815	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BFL16_RS04820	COG0314	molybdopterin synthase activity
BFL16_RS04825	COG0670	Belongs to the BI1 family
BFL16_RS04830	COG0670	Belongs to the BI1 family
BFL16_RS04835	COG0392	lysyltransferase activity
BFL16_RS04840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BFL16_RS04845	COG3568	Endonuclease Exonuclease Phosphatase
BFL16_RS04855	COG0842	Transport permease protein
BFL16_RS04860	COG0842	Transport permease protein
BFL16_RS04865	COG1131	(ABC) transporter
BFL16_RS04875	COG1309	transcriptional regulator
BFL16_RS04880	COG0513	Belongs to the DEAD box helicase family
BFL16_RS04900	COG1199	ATP-dependent helicase activity
BFL16_RS04905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BFL16_RS04910	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BFL16_RS04920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BFL16_RS04930	COG4774	siderophore transport
BFL16_RS04945	COG0668	transmembrane transport
BFL16_RS04955	COG1126	abc transporter atp-binding protein
BFL16_RS04960	COG0765	amino acid transport
BFL16_RS04965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL16_RS04990	COG5006	permease, DMT superfamily
BFL16_RS04995	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BFL16_RS05000	COG2194	sulfuric ester hydrolase activity
BFL16_RS05010	COG1321	iron dependent repressor
BFL16_RS05015	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BFL16_RS05020	COG1376	ErfK ybiS ycfS ynhG family protein
BFL16_RS05025	COG0488	(ABC) transporter
BFL16_RS05035	COG0561	phosphatase activity
BFL16_RS05045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BFL16_RS05050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BFL16_RS05055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BFL16_RS05060	COG0303	'Molybdopterin
BFL16_RS05065	COG1446	asparaginase
BFL16_RS05070	COG1446	asparaginase
BFL16_RS05075	COG4172	Belongs to the ABC transporter superfamily
BFL16_RS05080	COG0747	negative chemotaxis
BFL16_RS05085	COG0601	transmembrane transport
BFL16_RS05095	COG2200	EAL domain
BFL16_RS05100	COG2199	diguanylate cyclase activity
BFL16_RS05125	COG2133	pyrroloquinoline quinone binding
BFL16_RS05130	COG0625	glutathione transferase activity
BFL16_RS05135	COG1686	Belongs to the peptidase S11 family
BFL16_RS05140	COG1349	DNA-binding transcription factor activity
BFL16_RS05145	COG0671	phosphoesterase, PA-phosphatase related
BFL16_RS05150	COG2814	Major facilitator Superfamily
BFL16_RS05160	COG0561	phosphatase activity
BFL16_RS05165	COG0738	Major facilitator superfamily
BFL16_RS05170	COG3226	Transcriptional regulator
BFL16_RS05185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BFL16_RS05195	COG0778	Nitroreductase
BFL16_RS05215	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BFL16_RS05220	COG3842	ATPase activity
BFL16_RS05225	COG1176	ABC-type spermidine putrescine transport system, permease component I
BFL16_RS05230	COG1177	transmembrane transport
BFL16_RS05260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL16_RS05265	COG4160	amino acid transport
BFL16_RS05270	COG4215	(ABC) transporter
BFL16_RS05275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL16_RS05280	COG1126	abc transporter atp-binding protein
BFL16_RS05315	COG3023	N-Acetylmuramoyl-L-alanine amidase
BFL16_RS05320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFL16_RS05325	COG0702	epimerase
BFL16_RS05330	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BFL16_RS05335	COG0028	Belongs to the TPP enzyme family
BFL16_RS05340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFL16_RS05350	COG2431	L-lysine efflux transmembrane transporter activity
BFL16_RS05360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BFL16_RS05370	COG3593	DNA synthesis involved in DNA repair
BFL16_RS05375	COG2990	Protein conserved in bacteria
BFL16_RS05380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL16_RS05385	COG0577	efflux transmembrane transporter activity
BFL16_RS05385	COG1136	(ABC) transporter
BFL16_RS05390	COG1278	Cold shock
BFL16_RS05475	COG0542	response to heat
BFL16_RS05505	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BFL16_RS05510	COG4988	ABC transporter
BFL16_RS05515	COG0492	ferredoxin-NADP+ reductase activity
BFL16_RS05525	COG1522	sequence-specific DNA binding
BFL16_RS05530	COG1674	ftsk spoiiie
BFL16_RS05530	COG1178	ABC-type Fe3 transport system permease component
BFL16_RS05540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BFL16_RS05550	COG0243	molybdopterin cofactor binding
BFL16_RS05555	COG0437	4 iron, 4 sulfur cluster binding
BFL16_RS05560	COG3302	dmso reductase anchor subunit
BFL16_RS05565	COG1335	isochorismatase
BFL16_RS05575	COG0531	amino acid
BFL16_RS05580	COG0583	DNA-binding transcription factor activity
BFL16_RS05585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BFL16_RS05595	COG1944	ATP diphosphatase activity
BFL16_RS05600	COG2323	membrane
BFL16_RS05615	COG0501	Belongs to the peptidase M48B family
BFL16_RS05625	COG0539	negative regulation of cytoplasmic translation
BFL16_RS05635	COG2333	competence protein COMEC
BFL16_RS05635	COG0658	competence protein
BFL16_RS05640	COG1132	(ABC) transporter
BFL16_RS05650	COG3214	Protein conserved in bacteria
BFL16_RS05665	COG3173	Aminoglycoside phosphotransferase
BFL16_RS05670	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BFL16_RS05675	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BFL16_RS05685	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
BFL16_RS05695	COG2989	Protein conserved in bacteria
BFL16_RS05705	COG3108	Peptidase M15
BFL16_RS05710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFL16_RS05715	COG1448	Aminotransferase
BFL16_RS05730	COG0017	Asparaginyl-tRNA synthetase
BFL16_RS05740	COG0308	aminopeptidase N
BFL16_RS05745	COG1116	anion transmembrane transporter activity
BFL16_RS05750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFL16_RS05760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BFL16_RS05765	COG0431	NADPH-dependent FMN reductase
BFL16_RS05775	COG3539	Fimbrial protein
BFL16_RS05780	COG3121	Chaperone
BFL16_RS05785	COG3188	usher protein
BFL16_RS05790	COG3188	usher protein
BFL16_RS05795	COG3539	Fimbrial protein
BFL16_RS05805	COG3539	Fimbrial protein
BFL16_RS05810	COG3539	Fimbrial protein
BFL16_RS05830	COG3217	Mosc domain protein beta barrel domain protein
BFL16_RS05830	COG0633	Ferredoxin
BFL16_RS05840	COG0488	(ABC) transporter
BFL16_RS05845	COG2995	paraquat-inducible protein a
BFL16_RS05850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BFL16_RS05850	COG3008	intermembrane lipid transfer
BFL16_RS05855	COG3009	Protein conserved in bacteria
BFL16_RS05860	COG3130	regulation of translation
BFL16_RS05870	COG1067	ATP-dependent peptidase activity
BFL16_RS05880	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BFL16_RS05880	COG2885	chlorophyll binding
BFL16_RS05895	COG3070	regulator of competence-specific genes
BFL16_RS05900	COG1289	transmembrane transporter activity
BFL16_RS05905	COG3304	Inner membrane component domain
BFL16_RS05910	COG0210	DNA helicase
BFL16_RS05930	COG1832	CoA-binding protein
BFL16_RS05945	COG1254	Belongs to the acylphosphatase family
BFL16_RS05950	COG2920	part of a sulfur-relay system
BFL16_RS05955	COG0670	Belongs to the BI1 family
BFL16_RS05970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFL16_RS06055	COG1484	DNA-dependent DNA replication
BFL16_RS06060	COG1846	Transcriptional regulator
BFL16_RS06085	COG1403	HNH endonuclease
BFL16_RS06090	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BFL16_RS06110	COG2207	Transcriptional regulator
BFL16_RS06155	COG3772	lysozyme
BFL16_RS06195	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS06200	COG4372	Transposase
BFL16_RS06205	COG4220	transposase activity
BFL16_RS06290	COG2032	superoxide dismutase activity
BFL16_RS06305	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS06330	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BFL16_RS06335	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
BFL16_RS06340	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
BFL16_RS06345	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BFL16_RS06350	COG1999	signal sequence binding
BFL16_RS06355	COG1773	rubredoxin
BFL16_RS06360	COG1271	oxidase subunit
BFL16_RS06365	COG1294	oxidase, subunit
BFL16_RS06380	COG0489	protein tyrosine kinase activity
BFL16_RS06380	COG3206	protein involved in exopolysaccharide biosynthesis
BFL16_RS06385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BFL16_RS06390	COG1596	polysaccharide export
BFL16_RS06395	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFL16_RS06415	COG1278	Cold shock
BFL16_RS06420	COG1278	Cold shock
BFL16_RS06440	COG0348	domain, Protein
BFL16_RS06445	COG0784	Response regulator, receiver
BFL16_RS06445	COG2198	Histidine kinase
BFL16_RS06445	COG2205	protein histidine kinase activity
BFL16_RS06450	COG1879	ABC-type sugar transport system periplasmic component
BFL16_RS06455	COG0745	RESPONSE REGULATOR receiver
BFL16_RS06460	COG3005	denitrification pathway
BFL16_RS06465	COG0243	molybdopterin cofactor binding
BFL16_RS06505	COG3729	General stress protein
BFL16_RS06510	COG2233	PERMEase
BFL16_RS06545	COG1309	transcriptional regulator
BFL16_RS06550	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BFL16_RS06550	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BFL16_RS06550	COG0506	proline dehydrogenase activity
BFL16_RS06565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFL16_RS06580	COG2822	iron ion transport
BFL16_RS06585	COG2837	iron assimilation
BFL16_RS06595	COG1702	phosphate starvation-inducible protein PhoH
BFL16_RS06600	COG3658	cytochrome
BFL16_RS06605	COG1215	transferase activity, transferring glycosyl groups
BFL16_RS06610	COG0726	polysaccharide deacetylase
BFL16_RS06610	COG1649	PFAM Uncharacterised BCR, COG1649
BFL16_RS06615	COG0457	Tetratricopeptide repeat
BFL16_RS06620	COG3706	GGDEF domain
BFL16_RS06625	COG2200	EAL domain
BFL16_RS06635	COG3710	Transcriptional regulator
BFL16_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS06645	COG3121	Chaperone
BFL16_RS06655	COG3188	usher protein
BFL16_RS06665	COG3539	Fimbrial protein
BFL16_RS06675	COG3210	domain, Protein
BFL16_RS06680	COG2831	hemolysin activation secretion protein
BFL16_RS06685	COG0736	holo-[acyl-carrier-protein] synthase activity
BFL16_RS06695	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BFL16_RS06705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BFL16_RS06710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFL16_RS06760	COG0582	viral genome integration into host DNA
BFL16_RS06795	COG4983	Phage plasmid primase, P4 family domain protein
BFL16_RS06815	COG2826	transposase and inactivated derivatives, IS30 family
BFL16_RS06820	COG4372	Transposase
BFL16_RS06825	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS06835	COG2826	transposase and inactivated derivatives, IS30 family
BFL16_RS06840	COG2963	transposase activity
BFL16_RS06875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BFL16_RS06880	COG2194	sulfuric ester hydrolase activity
BFL16_RS06895	COG0829	nickel cation binding
BFL16_RS06910	COG0804	urea catabolic process
BFL16_RS06945	COG0254	rRNA binding
BFL16_RS06985	COG2433	Pfam Transposase IS66
BFL16_RS06995	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS07000	COG4372	Transposase
BFL16_RS07005	COG4372	Transposase
BFL16_RS07035	COG1358	cellular component organization or biogenesis
BFL16_RS07125	COG4771	TonB-dependent receptor
BFL16_RS07155	COG2801	Transposase and inactivated derivatives
BFL16_RS07205	COG3677	Transposase
BFL16_RS07255	COG3468	outer membrane autotransporter barrel domain protein
BFL16_RS07295	COG2003	Belongs to the UPF0758 family
BFL16_RS07350	COG3381	protein complex oligomerization
BFL16_RS07360	COG1462	curli production assembly transport component CsgG
BFL16_RS07375	COG2197	response regulator
BFL16_RS07410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BFL16_RS07415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BFL16_RS07430	COG2943	transferase activity, transferring hexosyl groups
BFL16_RS07435	COG5645	(Lipo)protein
BFL16_RS07455	COG1560	Kdo2-lipid A biosynthetic process
BFL16_RS07465	COG2353	YceI-like domain
BFL16_RS07470	COG3038	cytochrome b561
BFL16_RS07510	COG2999	glutathione oxidoreductase activity
BFL16_RS07520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFL16_RS07530	COG0673	inositol 2-dehydrogenase activity
BFL16_RS07535	COG0728	peptidoglycan biosynthetic process
BFL16_RS07540	COG3418	PFAM FlgN family protein
BFL16_RS07545	COG2747	anti-sigma28 factor FlgM
BFL16_RS07550	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
BFL16_RS07555	COG1815	bacterial-type flagellum-dependent cell motility
BFL16_RS07560	COG1558	bacterial-type flagellum-dependent cell motility
BFL16_RS07565	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BFL16_RS07570	COG1749	Flagellar hook protein flgE
BFL16_RS07575	COG4787	bacterial-type flagellum-dependent cell motility
BFL16_RS07580	COG4786	Flagellar basal body rod
BFL16_RS07595	COG1705	Flagellar rod assembly protein muramidase FlgJ
BFL16_RS07595	COG3951	Flagellar rod assembly protein muramidase FlgJ
BFL16_RS07600	COG1256	bacterial-type flagellum assembly
BFL16_RS07605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BFL16_RS07610	COG1530	ribonuclease E activity
BFL16_RS07620	COG0564	pseudouridine synthase activity
BFL16_RS07625	COG0424	maF-like protein
BFL16_RS07630	COG1399	metal-binding, possibly nucleic acid-binding protein
BFL16_RS07650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BFL16_RS07655	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS07665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFL16_RS07670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BFL16_RS07675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BFL16_RS07685	COG0470	DNA polymerase III
BFL16_RS07690	COG0084	hydrolase, TatD family'
BFL16_RS07695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFL16_RS07695	COG1263	PTS System
BFL16_RS07700	COG4773	Receptor
BFL16_RS07710	COG0537	adenosine 5'-monophosphoramidase activity
BFL16_RS07715	COG5633	Lipoprotein
BFL16_RS07720	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
BFL16_RS07725	COG0510	thiamine kinase activity
BFL16_RS07745	COG1252	NADH dehydrogenase
BFL16_RS07750	COG3134	Outer membrane lipoprotein
BFL16_RS07755	COG1309	transcriptional regulator
BFL16_RS07765	COG1376	ErfK ybiS ycfS ynhG family protein
BFL16_RS07765	COG1388	LysM domain
BFL16_RS07770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BFL16_RS07775	COG4763	Acyl-transferase
BFL16_RS07780	COG4591	ABC-type transport system involved in lipoprotein release permease component
BFL16_RS07785	COG1136	(ABC) transporter
BFL16_RS07790	COG4591	ABC-type transport system involved in lipoprotein release permease component
BFL16_RS07800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BFL16_RS07805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BFL16_RS07810	COG1177	transmembrane transport
BFL16_RS07815	COG0582	viral genome integration into host DNA
BFL16_RS07855	COG4197	protein conserved in bacteria, prophage-related
BFL16_RS07880	COG1846	Transcriptional regulator
BFL16_RS07940	COG1403	HNH endonuclease
BFL16_RS07945	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BFL16_RS07950	COG0484	heat shock protein binding
BFL16_RS08000	COG3772	lysozyme
BFL16_RS08165	COG4771	TonB-dependent receptor
BFL16_RS08180	COG3328	transposase activity
BFL16_RS08210	COG3842	ATPase activity
BFL16_RS08225	COG2850	peptidyl-arginine hydroxylation
BFL16_RS08320	COG4220	transposase activity
BFL16_RS08335	COG2205	protein histidine kinase activity
BFL16_RS08340	COG0745	RESPONSE REGULATOR receiver
BFL16_RS08345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BFL16_RS08355	COG0482	sulfurtransferase activity
BFL16_RS08365	COG1187	pseudouridine synthase activity
BFL16_RS08370	COG0538	isocitrate dehydrogenase activity
BFL16_RS08375	COG0582	viral genome integration into host DNA
BFL16_RS08400	COG2076	Multidrug Resistance protein
BFL16_RS08410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BFL16_RS08435	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BFL16_RS08475	COG5562	phage envelope protein
BFL16_RS08495	COG4220	transposase activity
BFL16_RS08515	COG1030	water channel activity
BFL16_RS08565	COG1196	nuclear chromosome segregation
BFL16_RS08600	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS08605	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BFL16_RS08610	COG3546	catalase activity
BFL16_RS08615	COG3685	Protein conserved in bacteria
BFL16_RS08620	COG3685	Protein conserved in bacteria
BFL16_RS08625	COG3729	General stress protein
BFL16_RS08630	COG0500	methyltransferase
BFL16_RS08645	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS08650	COG4372	Transposase
BFL16_RS08660	COG4571	Outer membrane protease
BFL16_RS08675	COG3468	outer membrane autotransporter barrel domain protein
BFL16_RS08690	COG2894	cell division
BFL16_RS08725	COG0179	Fumarylacetoacetate (FAA) hydrolase
BFL16_RS08740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BFL16_RS08745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BFL16_RS08750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BFL16_RS08765	COG2719	SpoVR family
BFL16_RS08775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BFL16_RS08805	COG1619	proteins homologs of microcin C7 resistance protein MccF
BFL16_RS08845	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BFL16_RS08860	COG0157	Belongs to the NadC ModD family
BFL16_RS08870	COG0500	methyltransferase
BFL16_RS08875	COG1120	ATPase activity
BFL16_RS08880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFL16_RS08885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BFL16_RS08905	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BFL16_RS08905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFL16_RS08905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS08910	COG1461	Dihydroxyacetone kinase
BFL16_RS08915	COG2376	Dihydroxyacetone kinase
BFL16_RS08920	COG3284	Transcriptional regulator
BFL16_RS08925	COG3468	outer membrane autotransporter barrel domain protein
BFL16_RS08935	COG0012	GTP binding
BFL16_RS08950	COG0659	secondary active sulfate transmembrane transporter activity
BFL16_RS08955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BFL16_RS08985	COG3094	Invasion gene expression up-regulator, SirB
BFL16_RS08990	COG2912	Transglutaminase-like superfamily
BFL16_RS09015	COG0387	Pfam Sodium calcium exchanger
BFL16_RS09020	COG4572	Cation transport regulator
BFL16_RS09025	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BFL16_RS09030	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BFL16_RS09035	COG4932	domain protein
BFL16_RS09040	COG2197	response regulator
BFL16_RS09045	COG3850	Histidine kinase
BFL16_RS09055	COG2223	nitrite transmembrane transporter activity
BFL16_RS09060	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BFL16_RS09065	COG1140	nitrate reductase beta subunit
BFL16_RS09070	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BFL16_RS09075	COG2181	nitrate reductase activity
BFL16_RS09105	COG0788	formyltetrahydrofolate deformylase activity
BFL16_RS09115	COG1752	Esterase of the alpha-beta hydrolase superfamily
BFL16_RS09120	COG0745	RESPONSE REGULATOR receiver
BFL16_RS09125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BFL16_RS09135	COG1435	thymidine kinase activity
BFL16_RS09140	COG1012	belongs to the aldehyde dehydrogenase family
BFL16_RS09140	COG1454	alcohol dehydrogenase
BFL16_RS09145	COG2095	MarC family integral membrane protein
BFL16_RS09150	COG4166	transmembrane transport
BFL16_RS09155	COG0601	transmembrane transport
BFL16_RS09160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFL16_RS09165	COG0444	Belongs to the ABC transporter superfamily
BFL16_RS09170	COG4608	Belongs to the ABC transporter superfamily
BFL16_RS09190	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BFL16_RS09195	COG2350	Protein conserved in bacteria
BFL16_RS09200	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
BFL16_RS09205	COG1607	acyl-coa hydrolase
BFL16_RS09220	COG3047	cAMP biosynthetic process
BFL16_RS09225	COG0582	viral genome integration into host DNA
BFL16_RS09235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFL16_RS09295	COG1846	Transcriptional regulator
BFL16_RS09300	COG1484	DNA-dependent DNA replication
BFL16_RS09305	COG1846	Transcriptional regulator
BFL16_RS09310	COG1846	Transcriptional regulator
BFL16_RS09345	COG1403	HNH endonuclease
BFL16_RS09350	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BFL16_RS09420	COG3772	lysozyme
BFL16_RS09560	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS09600	COG3328	transposase activity
BFL16_RS09610	COG4372	Transposase
BFL16_RS09615	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS09675	COG3047	cAMP biosynthetic process
BFL16_RS09680	COG3685	Protein conserved in bacteria
BFL16_RS09685	COG3685	Protein conserved in bacteria
BFL16_RS09690	COG3729	General stress protein
BFL16_RS09705	COG0134	indole-3-glycerol-phosphate synthase activity
BFL16_RS09705	COG0135	phosphoribosylanthranilate isomerase activity
BFL16_RS09710	COG0512	Glutamine amidotransferase of anthranilate synthase
BFL16_RS09710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BFL16_RS09715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BFL16_RS09725	COG0613	PHP domain protein
BFL16_RS09730	COG0009	L-threonylcarbamoyladenylate synthase
BFL16_RS09735	COG4907	membrane protein (DUF2207)
BFL16_RS09740	COG1187	pseudouridine synthase activity
BFL16_RS09745	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
BFL16_RS09750	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS09760	COG0616	signal peptide processing
BFL16_RS09770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BFL16_RS09780	COG0583	DNA-binding transcription factor activity
BFL16_RS09800	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BFL16_RS09810	COG0671	phosphoesterase, PA-phosphatase related
BFL16_RS09815	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
BFL16_RS09820	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BFL16_RS09830	COG0023	Translation Initiation Factor
BFL16_RS09840	COG1349	DNA-binding transcription factor activity
BFL16_RS09850	COG5001	Diguanylate cyclase
BFL16_RS09860	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFL16_RS09860	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFL16_RS09865	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BFL16_RS09880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL16_RS09895	COG2814	Major facilitator Superfamily
BFL16_RS09900	COG4172	Belongs to the ABC transporter superfamily
BFL16_RS09905	COG4172	Belongs to the ABC transporter superfamily
BFL16_RS09910	COG4171	peptide transport system, permease
BFL16_RS09915	COG4168	peptide transport system, permease
BFL16_RS09920	COG4166	transmembrane transport
BFL16_RS09935	COG0531	amino acid
BFL16_RS09940	COG0174	glutamine synthetase
BFL16_RS09950	COG1396	sequence-specific DNA binding
BFL16_RS09950	COG1917	Cupin 2, conserved barrel domain protein
BFL16_RS09955	COG1012	belongs to the aldehyde dehydrogenase family
BFL16_RS09960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFL16_RS09965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BFL16_RS09970	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BFL16_RS09975	COG1842	Phage shock protein A
BFL16_RS09985	COG1983	PspC domain protein
BFL16_RS09995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BFL16_RS10000	COG0366	Alpha amylase catalytic
BFL16_RS10005	COG0366	Alpha amylase catalytic
BFL16_RS10010	COG1653	transport
BFL16_RS10015	COG1653	transport
BFL16_RS10020	COG1175	transmembrane transport
BFL16_RS10025	COG0395	ABC-type sugar transport system, permease component
BFL16_RS10030	COG1063	alcohol dehydrogenase
BFL16_RS10035	COG1082	Xylose isomerase domain protein TIM barrel
BFL16_RS10040	COG0673	inositol 2-dehydrogenase activity
BFL16_RS10045	COG1554	hydrolase, family 65, central catalytic
BFL16_RS10050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFL16_RS10055	COG3842	ATPase activity
BFL16_RS10065	COG1609	Transcriptional regulator
BFL16_RS10070	COG3106	COG3106 Predicted ATPase
BFL16_RS10080	COG3283	Transcriptional regulator of aromatic amino acids metabolism
BFL16_RS10085	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BFL16_RS10090	COG4948	Mandelate Racemase Muconate Lactonizing
BFL16_RS10095	COG2866	Carboxypeptidase
BFL16_RS10100	COG0702	epimerase
BFL16_RS10110	COG1073	alpha beta
BFL16_RS10115	COG0583	DNA-binding transcription factor activity
BFL16_RS10120	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BFL16_RS10125	COG4166	transmembrane transport
BFL16_RS10130	COG0668	transmembrane transport
BFL16_RS10135	COG3182	Iron-regulated membrane protein
BFL16_RS10140	COG0589	response to stress
BFL16_RS10145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFL16_RS10150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BFL16_RS10155	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BFL16_RS10160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BFL16_RS10170	COG1473	amidohydrolase
BFL16_RS10175	COG1473	amidohydrolase
BFL16_RS10180	COG0583	DNA-binding transcription factor activity
BFL16_RS10190	COG2840	Smr protein MutS2
BFL16_RS10195	COG3706	GGDEF domain
BFL16_RS10210	COG0513	Belongs to the DEAD box helicase family
BFL16_RS10220	COG0589	response to stress
BFL16_RS10225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BFL16_RS10230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BFL16_RS10240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFL16_RS10240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BFL16_RS10240	COG0674	pyruvate-flavodoxin oxidoreductase activity
BFL16_RS10240	COG1013	pyruvate-flavodoxin oxidoreductase activity
BFL16_RS10245	COG3042	response to heat
BFL16_RS10250	COG3187	Heat shock protein
BFL16_RS10255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BFL16_RS10260	COG2911	Protein conserved in bacteria
BFL16_RS10270	COG3784	Protein of unknown function (DUF1318)
BFL16_RS10285	COG0667	Aldo Keto reductase
BFL16_RS10295	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BFL16_RS10300	COG4589	Belongs to the CDS family
BFL16_RS10305	COG2267	carboxylic ester hydrolase activity
BFL16_RS10310	COG2453	phosphatase
BFL16_RS10310	COG0671	phosphoesterase, PA-phosphatase related
BFL16_RS10315	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BFL16_RS10320	COG1643	Atp-dependent helicase
BFL16_RS10345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BFL16_RS10350	COG1012	belongs to the aldehyde dehydrogenase family
BFL16_RS10355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BFL16_RS10360	COG3038	cytochrome b561
BFL16_RS10380	COG0840	transmembrane signaling receptor activity
BFL16_RS10385	COG0583	DNA-binding transcription factor activity
BFL16_RS10390	COG5383	Protein conserved in bacteria
BFL16_RS10410	COG2841	Protein conserved in bacteria
BFL16_RS10415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFL16_RS10420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFL16_RS10425	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BFL16_RS10430	COG1275	C4-dicarboxylate transporter malic acid transport protein
BFL16_RS10435	COG0500	methyltransferase
BFL16_RS10445	COG3135	benzoate transporter
BFL16_RS10450	COG1396	sequence-specific DNA binding
BFL16_RS10455	COG0826	peptidase U32
BFL16_RS10465	COG1724	mRNA binding
BFL16_RS10470	COG1598	PFAM Uncharacterised protein family UPF0150
BFL16_RS10475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFL16_RS10480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BFL16_RS10485	COG3842	ATPase activity
BFL16_RS10490	COG1176	ABC-type spermidine putrescine transport system, permease component I
BFL16_RS10495	COG1177	transmembrane transport
BFL16_RS10525	COG3238	Protein conserved in bacteria
BFL16_RS10530	COG1247	-acetyltransferase
BFL16_RS10540	COG2130	NADP-dependent
BFL16_RS10545	COG1802	Transcriptional regulator
BFL16_RS10550	COG4772	TonB-dependent receptor
BFL16_RS10565	COG3391	amine dehydrogenase activity
BFL16_RS10570	COG1113	amino acid transport
BFL16_RS10575	COG0625	glutathione transferase activity
BFL16_RS10590	COG3209	COG3209 Rhs family protein
BFL16_RS10615	COG5433	transposase activity
BFL16_RS10625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BFL16_RS10635	COG0384	phenazine biosynthesis protein PhzF
BFL16_RS10640	COG2181	nitrate reductase activity
BFL16_RS10645	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BFL16_RS10650	COG1140	nitrate reductase beta subunit
BFL16_RS10655	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BFL16_RS10660	COG2223	nitrite transmembrane transporter activity
BFL16_RS10665	COG4886	Leucine-rich repeat (LRR) protein
BFL16_RS10670	COG4886	Leucine-rich repeat (LRR) protein
BFL16_RS10685	COG0697	spore germination
BFL16_RS10690	COG0243	molybdopterin cofactor binding
BFL16_RS10690	COG3383	formate dehydrogenase (NAD+) activity
BFL16_RS10695	COG3383	formate dehydrogenase (NAD+) activity
BFL16_RS10695	COG0243	molybdopterin cofactor binding
BFL16_RS10700	COG0437	4 iron, 4 sulfur cluster binding
BFL16_RS10705	COG2864	formate dehydrogenase
BFL16_RS10715	COG3093	addiction module antidote protein HigA
BFL16_RS10720	COG1064	alcohol dehydrogenase
BFL16_RS10745	COG1764	response to oxidative stress
BFL16_RS10750	COG4608	Belongs to the ABC transporter superfamily
BFL16_RS10755	COG0444	Belongs to the ABC transporter superfamily
BFL16_RS10760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFL16_RS10765	COG0601	transmembrane transport
BFL16_RS10770	COG0747	negative chemotaxis
BFL16_RS10775	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
BFL16_RS10785	COG3706	GGDEF domain
BFL16_RS10790	COG1649	PFAM Uncharacterised BCR, COG1649
BFL16_RS10795	COG0531	amino acid
BFL16_RS10800	COG0076	glutamate decarboxylase activity
BFL16_RS10815	COG0612	Peptidase, M16
BFL16_RS10820	COG4771	TonB-dependent receptor
BFL16_RS10825	COG4178	(ABC) transporter
BFL16_RS10830	COG0641	radical SAM
BFL16_RS10835	COG3119	arylsulfatase activity
BFL16_RS10840	COG2207	Transcriptional regulator
BFL16_RS10850	COG0243	molybdopterin cofactor binding
BFL16_RS10855	COG4977	sequence-specific DNA binding
BFL16_RS10860	COG3550	peptidyl-serine autophosphorylation
BFL16_RS10870	COG3210	domain, Protein
BFL16_RS10870	COG2911	Protein conserved in bacteria
BFL16_RS10875	COG1070	Carbohydrate kinase
BFL16_RS10885	COG1129	ABC transporter
BFL16_RS10890	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS10895	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS10905	COG1830	Aldolase
BFL16_RS10920	COG3781	membrane
BFL16_RS10940	COG2199	diguanylate cyclase activity
BFL16_RS10950	COG2066	Belongs to the glutaminase family
BFL16_RS10955	COG1012	belongs to the aldehyde dehydrogenase family
BFL16_RS10960	COG0583	DNA-binding transcription factor activity
BFL16_RS10975	COG2814	Major facilitator Superfamily
BFL16_RS10980	COG2095	MarC family integral membrane protein
BFL16_RS10985	COG1846	Transcriptional regulator
BFL16_RS10990	COG4977	sequence-specific DNA binding
BFL16_RS11000	COG0697	spore germination
BFL16_RS11005	COG2814	Major facilitator Superfamily
BFL16_RS11025	COG3706	GGDEF domain
BFL16_RS11030	COG3111	PFAM Bacterial OB fold (BOF) protein
BFL16_RS11035	COG1546	Belongs to the CinA family
BFL16_RS11045	COG0339	signal peptide processing
BFL16_RS11050	COG4221	oxidoreductase activity
BFL16_RS11055	COG1802	Transcriptional regulator
BFL16_RS11065	COG0246	Mannitol dehydrogenase
BFL16_RS11070	COG0477	Major facilitator Superfamily
BFL16_RS11100	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS11175	COG0740	serine-type endopeptidase activity
BFL16_RS11220	COG3772	lysozyme
BFL16_RS11260	COG0484	heat shock protein binding
BFL16_RS11265	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BFL16_RS11270	COG1403	HNH endonuclease
BFL16_RS11295	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BFL16_RS11305	COG1846	Transcriptional regulator
BFL16_RS11310	COG1484	DNA-dependent DNA replication
BFL16_RS11315	COG1846	Transcriptional regulator
BFL16_RS11375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFL16_RS11385	COG0582	viral genome integration into host DNA
BFL16_RS11420	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS11505	COG1030	water channel activity
BFL16_RS11525	COG4220	transposase activity
BFL16_RS11560	COG3772	lysozyme
BFL16_RS11610	COG2207	Transcriptional regulator
BFL16_RS11625	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BFL16_RS11630	COG1403	HNH endonuclease
BFL16_RS11640	COG3111	PFAM Bacterial OB fold (BOF) protein
BFL16_RS11675	COG1846	Transcriptional regulator
BFL16_RS11740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFL16_RS11745	COG0582	viral genome integration into host DNA
BFL16_RS11755	COG3328	transposase activity
BFL16_RS11765	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS11770	COG4372	Transposase
BFL16_RS11775	COG3328	transposase activity
BFL16_RS11800	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS11950	COG3772	lysozyme
BFL16_RS12000	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BFL16_RS12005	COG1403	HNH endonuclease
BFL16_RS12040	COG1846	Transcriptional regulator
BFL16_RS12060	COG1396	sequence-specific DNA binding
BFL16_RS12100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFL16_RS12135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFL16_RS12150	COG0243	molybdopterin cofactor binding
BFL16_RS12155	COG0243	molybdopterin cofactor binding
BFL16_RS12160	COG0437	4 iron, 4 sulfur cluster binding
BFL16_RS12165	COG3302	dmso reductase anchor subunit
BFL16_RS12170	COG3381	protein complex oligomerization
BFL16_RS12180	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BFL16_RS12185	COG1940	carbohydrate kinase activity
BFL16_RS12190	COG0583	DNA-binding transcription factor activity
BFL16_RS12195	COG2814	Major facilitator Superfamily
BFL16_RS12215	COG3591	Belongs to the peptidase S1B family
BFL16_RS12230	COG0628	permease
BFL16_RS12235	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BFL16_RS12240	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BFL16_RS12255	COG0531	amino acid
BFL16_RS12265	COG3136	membrane protein required for alginate biosynthesis
BFL16_RS12270	COG0745	RESPONSE REGULATOR receiver
BFL16_RS12275	COG2205	protein histidine kinase activity
BFL16_RS12285	COG0114	fumarate hydratase activity
BFL16_RS12290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BFL16_RS12290	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BFL16_RS12295	COG1482	cell wall glycoprotein biosynthetic process
BFL16_RS12300	COG5339	Protein conserved in bacteria
BFL16_RS12320	COG1309	transcriptional regulator
BFL16_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS12330	COG1609	Transcriptional regulator
BFL16_RS12335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFL16_RS12335	COG1263	PTS System
BFL16_RS12340	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BFL16_RS12350	COG0673	inositol 2-dehydrogenase activity
BFL16_RS12385	COG4656	Part of a membrane complex involved in electron transport
BFL16_RS12395	COG4659	FMN binding
BFL16_RS12405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BFL16_RS12415	COG3104	oligopeptide transport
BFL16_RS12420	COG0625	glutathione transferase activity
BFL16_RS12425	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BFL16_RS12440	COG3895	Periplasmic Protein
BFL16_RS12450	COG3133	Outer membrane lipoprotein
BFL16_RS12465	COG1566	PFAM secretion protein HlyD family protein
BFL16_RS12470	COG1289	transmembrane transporter activity
BFL16_RS12475	COG2032	superoxide dismutase activity
BFL16_RS12480	COG4989	oxidoreductase activity
BFL16_RS12485	COG3313	Fe-S protein
BFL16_RS12490	COG1309	transcriptional regulator
BFL16_RS12495	COG1902	pentaerythritol trinitrate reductase activity
BFL16_RS12500	COG0346	lactoylglutathione lyase activity
BFL16_RS12510	COG1201	RNA secondary structure unwinding
BFL16_RS12515	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BFL16_RS12520	COG0791	NLP P60 protein
BFL16_RS12525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BFL16_RS12530	COG2814	Major facilitator Superfamily
BFL16_RS12550	COG0583	DNA-binding transcription factor activity
BFL16_RS12555	COG2814	Major facilitator Superfamily
BFL16_RS12560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BFL16_RS12565	COG0307	riboflavin synthase, alpha
BFL16_RS12575	COG3468	outer membrane autotransporter barrel domain protein
BFL16_RS12595	COG4529	Protein conserved in bacteria
BFL16_RS12605	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
BFL16_RS12610	COG0437	4 iron, 4 sulfur cluster binding
BFL16_RS12620	COG2414	aldehyde ferredoxin oxidoreductase
BFL16_RS12625	COG0437	4 iron, 4 sulfur cluster binding
BFL16_RS12635	COG0469	pyruvate kinase activity
BFL16_RS12640	COG4238	major outer membrane lipoprotein
BFL16_RS12645	COG1376	ErfK ybiS ycfS ynhG family protein
BFL16_RS12660	COG0719	Fe-S assembly protein
BFL16_RS12665	COG0396	ATPase activity
BFL16_RS12670	COG0719	Fe-S assembly protein
BFL16_RS12675	COG0316	Belongs to the HesB IscA family
BFL16_RS12685	COG2050	protein possibly involved in aromatic compounds catabolism
BFL16_RS12690	COG0277	FAD linked oxidase domain protein
BFL16_RS12690	COG0247	lactate metabolic process
BFL16_RS12695	COG0628	permease
BFL16_RS12710	COG0738	Major facilitator superfamily
BFL16_RS12715	COG2271	Major facilitator Superfamily
BFL16_RS12730	COG4670	ketone body catabolic process
BFL16_RS12735	COG1960	acyl-CoA dehydrogenase activity
BFL16_RS12740	COG1917	Cupin 2, conserved barrel domain protein
BFL16_RS12740	COG2207	Transcriptional regulator
BFL16_RS12750	COG2086	electron transfer activity
BFL16_RS12755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BFL16_RS12760	COG0644	oxidoreductase
BFL16_RS12765	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BFL16_RS12770	COG0318	PFAM AMP-dependent synthetase and ligase
BFL16_RS12775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFL16_RS12775	COG0574	Belongs to the PEP-utilizing enzyme family
BFL16_RS12785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BFL16_RS12790	COG4256	Hemin uptake protein
BFL16_RS12800	COG2200	EAL domain
BFL16_RS12805	COG0791	NLP P60 protein
BFL16_RS12815	COG0386	Belongs to the glutathione peroxidase family
BFL16_RS12830	COG0072	phenylalanine-tRNA ligase activity
BFL16_RS12830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFL16_RS12880	COG3137	Salt-induced outer membrane protein
BFL16_RS12885	COG1105	Belongs to the carbohydrate kinase PfkB family
BFL16_RS12895	COG3001	Fructosamine kinase
BFL16_RS12905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFL16_RS12910	COG1988	membrane-bound metal-dependent
BFL16_RS12915	COG1823	symporter activity
BFL16_RS12930	COG0753	catalase activity
BFL16_RS12940	COG1486	melibiose metabolic process
BFL16_RS12945	COG1917	Cupin 2, conserved barrel domain protein
BFL16_RS12945	COG2169	Transcriptional regulator
BFL16_RS12950	COG1447	Phosphotransferase system cellobiose-specific component IIA
BFL16_RS12955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BFL16_RS12960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BFL16_RS12970	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFL16_RS12980	COG0322	excinuclease ABC activity
BFL16_RS12990	COG3678	ATP-independent chaperone mediated protein folding
BFL16_RS13020	COG0708	Exodeoxyribonuclease III
BFL16_RS13025	COG0398	Pfam SNARE associated Golgi protein
BFL16_RS13035	COG0398	Pfam SNARE associated Golgi protein
BFL16_RS13040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFL16_RS13045	COG4134	Bacterial extracellular solute-binding protein
BFL16_RS13050	COG4135	transport system, permease component
BFL16_RS13055	COG4136	ATPase activity
BFL16_RS13060	COG2897	thiosulfate sulfurtransferase activity
BFL16_RS13065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BFL16_RS13070	COG0494	nUDIX hydrolase
BFL16_RS13080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BFL16_RS13090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BFL16_RS13095	COG0709	Synthesizes selenophosphate from selenide and ATP
BFL16_RS13105	COG0778	Nitroreductase
BFL16_RS13110	COG0616	signal peptide processing
BFL16_RS13120	COG0252	asparaginase activity
BFL16_RS13125	COG1335	isochorismatase
BFL16_RS13130	COG2814	Major facilitator Superfamily
BFL16_RS13160	COG2814	Major facilitator Superfamily
BFL16_RS13165	COG1349	DNA-binding transcription factor activity
BFL16_RS13170	COG0667	Aldo Keto reductase
BFL16_RS13175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL16_RS13180	COG0191	fructose-bisphosphate aldolase activity
BFL16_RS13185	COG1063	alcohol dehydrogenase
BFL16_RS13190	COG2271	Major facilitator Superfamily
BFL16_RS13195	COG1063	alcohol dehydrogenase
BFL16_RS13200	COG3139	Protein of unknown function (DUF1315)
BFL16_RS13210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BFL16_RS13215	COG0676	glucose-6-phosphate 1-epimerase activity
BFL16_RS13220	COG0656	L-ascorbic acid biosynthetic process
BFL16_RS13225	COG3713	MltA-interacting MipA family protein
BFL16_RS13230	COG2766	serine protein kinase
BFL16_RS13240	COG2199	diguanylate cyclase activity
BFL16_RS13245	COG2199	diguanylate cyclase activity
BFL16_RS13250	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BFL16_RS13265	COG2207	Transcriptional regulator
BFL16_RS13270	COG2807	transmembrane transport
BFL16_RS13275	COG3189	MarR family transcriptional regulator
BFL16_RS13280	COG3042	response to heat
BFL16_RS13285	COG2203	Gaf domain
BFL16_RS13285	COG2199	diguanylate cyclase activity
BFL16_RS13300	COG2261	transglycosylase associated protein
BFL16_RS13310	COG3615	Tellurite resistance protein tehB
BFL16_RS13315	COG1280	lysine exporter protein (LysE YggA)
BFL16_RS13320	COG0583	DNA-binding transcription factor activity
BFL16_RS13325	COG0473	3-isopropylmalate dehydrogenase activity
BFL16_RS13330	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BFL16_RS13335	COG4638	Rieske (2fe-2S)
BFL16_RS13340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFL16_RS13345	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BFL16_RS13350	COG0318	PFAM AMP-dependent synthetase and ligase
BFL16_RS13355	COG3065	identical protein binding
BFL16_RS13360	COG1214	PFAM Peptidase M22, glycoprotease
BFL16_RS13365	COG1199	ATP-dependent helicase activity
BFL16_RS13370	COG0251	oxidation-reduction process
BFL16_RS13385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BFL16_RS13395	COG1760	l-serine dehydratase
BFL16_RS13400	COG2200	EAL domain
BFL16_RS13405	COG1253	flavin adenine dinucleotide binding
BFL16_RS13420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFL16_RS13420	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS13425	COG3715	PTS system
BFL16_RS13430	COG3716	PTS system mannose fructose sorbose family IID component
BFL16_RS13450	COG2226	methyltransferase
BFL16_RS13485	COG1414	Transcriptional regulator
BFL16_RS13490	COG2814	Major facilitator Superfamily
BFL16_RS13500	COG0793	Belongs to the peptidase S41A family
BFL16_RS13510	COG1956	GAF domain-containing protein
BFL16_RS13515	COG2995	paraquat-inducible protein a
BFL16_RS13520	COG3008	intermembrane lipid transfer
BFL16_RS13540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BFL16_RS13555	COG1276	copper resistance
BFL16_RS13560	COG2372	response to copper ion
BFL16_RS13570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BFL16_RS13575	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFL16_RS13580	COG1770	oligopeptidase
BFL16_RS13590	COG2979	Protein of unknown function (DUF533)
BFL16_RS13610	COG3141	response to X-ray
BFL16_RS13615	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BFL16_RS13620	COG0800	Aldolase
BFL16_RS13625	COG0129	dihydroxy-acid dehydratase activity
BFL16_RS13630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BFL16_RS13645	COG1737	Transcriptional regulator
BFL16_RS13650	COG0469	pyruvate kinase activity
BFL16_RS13655	COG1560	Kdo2-lipid A biosynthetic process
BFL16_RS13660	COG0739	heme binding
BFL16_RS13665	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
BFL16_RS13675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BFL16_RS13705	COG0217	transcriptional regulatory protein
BFL16_RS13710	COG0494	nUDIX hydrolase
BFL16_RS13715	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BFL16_RS13720	COG1335	isochorismatase
BFL16_RS13725	COG1801	Protein of unknown function DUF72
BFL16_RS13730	COG3788	relative of glutathione S-transferase, MAPEG superfamily
BFL16_RS13745	COG0243	molybdopterin cofactor binding
BFL16_RS13750	COG3005	denitrification pathway
BFL16_RS13760	COG3102	Protein conserved in bacteria
BFL16_RS13775	COG3755	Protein conserved in bacteria
BFL16_RS13785	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BFL16_RS13790	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BFL16_RS13800	COG0745	RESPONSE REGULATOR receiver
BFL16_RS13805	COG2201	protein-glutamate methylesterase activity
BFL16_RS13810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BFL16_RS13815	COG0840	transmembrane signaling receptor activity
BFL16_RS13820	COG0840	transmembrane signaling receptor activity
BFL16_RS13825	COG0835	chemotaxis
BFL16_RS13830	COG2198	Histidine kinase
BFL16_RS13830	COG0643	Histidine kinase
BFL16_RS13835	COG1360	Flagellar Motor Protein
BFL16_RS13840	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BFL16_RS13855	COG0589	response to stress
BFL16_RS13865	COG1877	trehalose-phosphatase activity
BFL16_RS13870	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS13875	COG1129	ABC transporter
BFL16_RS13880	COG1879	ABC-type sugar transport system periplasmic component
BFL16_RS13890	COG1528	Iron-storage protein
BFL16_RS13910	COG1528	Iron-storage protein
BFL16_RS13920	COG0814	amino acid
BFL16_RS13925	COG3012	SEC-C Motif Domain Protein
BFL16_RS13925	COG3318	Belongs to the UPF0149 family
BFL16_RS13930	COG4974	Belongs to the 'phage' integrase family
BFL16_RS14040	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BFL16_RS14085	COG2826	transposase and inactivated derivatives, IS30 family
BFL16_RS14120	COG2197	response regulator
BFL16_RS14140	COG2197	response regulator
BFL16_RS14145	COG1126	abc transporter atp-binding protein
BFL16_RS14150	COG0765	amino acid transport
BFL16_RS14160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL16_RS14170	COG1191	sigma factor activity
BFL16_RS14185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BFL16_RS14190	COG1516	flagellar protein fliS
BFL16_RS14200	COG0366	Alpha amylase catalytic
BFL16_RS14215	COG2391	methyltransferase activity
BFL16_RS14220	COG0425	Belongs to the sulfur carrier protein TusA family
BFL16_RS14225	COG2135	peptidase activity
BFL16_RS14230	COG0454	-acetyltransferase
BFL16_RS14260	COG1766	The M ring may be actively involved in energy transduction
BFL16_RS14265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BFL16_RS14270	COG1317	bacterial-type flagellum organization
BFL16_RS14275	COG1157	protein secretion by the type III secretion system
BFL16_RS14280	COG2882	bacterial-type flagellum organization
BFL16_RS14285	COG3144	bacterial-type flagellum assembly
BFL16_RS14290	COG1580	Controls the rotational direction of flagella during chemotaxis
BFL16_RS14295	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BFL16_RS14300	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BFL16_RS14305	COG3190	flagellar
BFL16_RS14310	COG1338	Plays a role in the flagellum-specific transport system
BFL16_RS14315	COG1987	bacterial-type flagellum assembly
BFL16_RS14320	COG1684	flagellar biosynthetic protein fliR
BFL16_RS14325	COG2197	response regulator
BFL16_RS14350	COG3706	GGDEF domain
BFL16_RS14360	COG5475	Uncharacterized small protein (DUF2158)
BFL16_RS14365	COG2354	Protein conserved in bacteria
BFL16_RS14370	COG0697	spore germination
BFL16_RS14375	COG3727	T/G mismatch-specific endonuclease activity
BFL16_RS14380	COG0270	DNA (cytosine-5-)-methyltransferase activity
BFL16_RS14385	COG1418	mRNA catabolic process
BFL16_RS14405	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BFL16_RS14420	COG2205	protein histidine kinase activity
BFL16_RS14425	COG0745	RESPONSE REGULATOR receiver
BFL16_RS14430	COG2351	hydroxyisourate hydrolase activity
BFL16_RS14445	COG3443	Belongs to the bacterial solute-binding protein 9 family
BFL16_RS14450	COG3038	cytochrome b561
BFL16_RS14480	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS14565	COG4220	transposase activity
BFL16_RS14600	COG3772	lysozyme
BFL16_RS14690	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BFL16_RS14695	COG1403	HNH endonuclease
BFL16_RS14750	COG1846	Transcriptional regulator
BFL16_RS14805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFL16_RS14835	COG4932	domain protein
BFL16_RS14835	COG2373	Large extracellular alpha-helical protein
BFL16_RS14835	COG1388	LysM domain
BFL16_RS14840	COG4932	domain protein
BFL16_RS14840	COG1388	LysM domain
BFL16_RS14840	COG2373	Large extracellular alpha-helical protein
BFL16_RS14860	COG2373	Large extracellular alpha-helical protein
BFL16_RS14860	COG1388	LysM domain
BFL16_RS14860	COG4932	domain protein
BFL16_RS14875	COG0477	Major facilitator Superfamily
BFL16_RS14880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BFL16_RS14885	COG0217	transcriptional regulatory protein
BFL16_RS14900	COG0534	Mate efflux family protein
BFL16_RS14910	COG0583	DNA-binding transcription factor activity
BFL16_RS14915	COG0583	DNA-binding transcription factor activity
BFL16_RS14925	COG1376	ErfK ybiS ycfS ynhG family protein
BFL16_RS14940	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
BFL16_RS14950	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS14955	COG4372	Transposase
BFL16_RS14975	COG4771	TonB-dependent receptor
BFL16_RS15035	COG2003	Belongs to the UPF0758 family
BFL16_RS15070	COG4917	ethanolamine utilization protein
BFL16_RS15080	COG1289	transmembrane transporter activity
BFL16_RS15090	COG1686	Belongs to the peptidase S11 family
BFL16_RS15115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BFL16_RS15125	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS15255	COG3772	lysozyme
BFL16_RS15525	COG0582	viral genome integration into host DNA
BFL16_RS15530	COG2925	Exonuclease
BFL16_RS15535	COG0425	Belongs to the sulfur carrier protein TusA family
BFL16_RS15540	COG2391	methyltransferase activity
BFL16_RS15545	COG0531	amino acid
BFL16_RS15550	COG0583	DNA-binding transcription factor activity
BFL16_RS15555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFL16_RS15580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BFL16_RS15590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BFL16_RS15590	COG0131	Imidazoleglycerol-phosphate dehydratase
BFL16_RS15595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BFL16_RS15620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BFL16_RS15625	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BFL16_RS15645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BFL16_RS15650	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BFL16_RS15650	COG0662	Cupin 2, conserved barrel domain protein
BFL16_RS15655	COG1051	belongs to the nudix hydrolase family
BFL16_RS15660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFL16_RS15665	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BFL16_RS15675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BFL16_RS15700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BFL16_RS15705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFL16_RS15715	COG0438	transferase activity, transferring glycosyl groups
BFL16_RS15720	COG2327	Polysaccharide pyruvyl transferase
BFL16_RS15725	COG2244	polysaccharide biosynthetic process
BFL16_RS15730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BFL16_RS15735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BFL16_RS15740	COG0662	Cupin 2, conserved barrel domain protein
BFL16_RS15740	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BFL16_RS15745	COG0297	glycogen (starch) synthase activity
BFL16_RS15750	COG1051	belongs to the nudix hydrolase family
BFL16_RS15755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BFL16_RS15760	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BFL16_RS15765	COG0110	maltose O-acetyltransferase activity
BFL16_RS15770	COG1216	Glycosyl transferase, family 2
BFL16_RS15780	COG0438	transferase activity, transferring glycosyl groups
BFL16_RS15785	COG1045	serine acetyltransferase
BFL16_RS15790	COG0463	Glycosyl transferase, family 2
BFL16_RS15795	COG3206	protein involved in exopolysaccharide biosynthesis
BFL16_RS15795	COG0489	protein tyrosine kinase activity
BFL16_RS15800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BFL16_RS15805	COG1596	polysaccharide export
BFL16_RS15810	COG1253	flavin adenine dinucleotide binding
BFL16_RS15825	COG2982	Protein involved in outer membrane biogenesis
BFL16_RS15835	COG0572	uridine kinase
BFL16_RS15845	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BFL16_RS15855	COG0443	Heat shock 70 kDa protein
BFL16_RS15860	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
BFL16_RS15865	COG0631	protein serine/threonine phosphatase activity
BFL16_RS15870	COG4245	von Willebrand factor, type A
BFL16_RS15885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFL16_RS15900	COG2205	protein histidine kinase activity
BFL16_RS15905	COG0745	RESPONSE REGULATOR receiver
BFL16_RS15915	COG3422	double-strand break repair
BFL16_RS15920	COG0826	peptidase U32
BFL16_RS15945	COG1063	alcohol dehydrogenase
BFL16_RS15950	COG3775	system Galactitol-specific IIC component
BFL16_RS15955	COG3414	Phosphotransferase system galactitol-specific IIB component
BFL16_RS15960	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS15980	COG1830	Aldolase
BFL16_RS15985	COG2211	Major facilitator Superfamily
BFL16_RS15990	COG1397	ADP-ribosylglycohydrolase
BFL16_RS15995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL16_RS16000	COG2188	Transcriptional regulator
BFL16_RS16005	COG3757	hydrolase, family 25
BFL16_RS16010	COG0351	phosphomethylpyrimidine kinase
BFL16_RS16045	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BFL16_RS16050	COG5455	response to cobalt ion
BFL16_RS16055	COG3539	Fimbrial protein
BFL16_RS16065	COG3121	Chaperone
BFL16_RS16070	COG3539	Fimbrial protein
BFL16_RS16085	COG0489	protein tyrosine kinase activity
BFL16_RS16100	COG3831	ATPase activity
BFL16_RS16105	COG3831	ATPase activity
BFL16_RS16110	COG3831	ATPase activity
BFL16_RS16115	COG3831	ATPase activity
BFL16_RS16135	COG0714	Associated with various cellular activities
BFL16_RS16140	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BFL16_RS16145	COG2425	protein containing a von Willebrand factor type A (vWA) domain
BFL16_RS16150	COG3552	Protein containing von Willebrand factor type A (VWA) domain
BFL16_RS16155	COG4715	Zinc finger, swim domain protein
BFL16_RS16160	COG4808	Protein conserved in bacteria
BFL16_RS16165	COG4807	Protein conserved in bacteria
BFL16_RS16170	COG3279	Response regulator of the LytR AlgR family
BFL16_RS16175	COG3275	phosphorelay sensor kinase activity
BFL16_RS16190	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS16265	COG0740	serine-type endopeptidase activity
BFL16_RS16310	COG3772	lysozyme
BFL16_RS16530	COG0582	viral genome integration into host DNA
BFL16_RS16535	COG0789	Transcriptional regulator
BFL16_RS16545	COG1174	glycine betaine transport
BFL16_RS16550	COG1125	glycine betaine transport
BFL16_RS16555	COG1174	glycine betaine transport
BFL16_RS16560	COG1732	Glycine betaine
BFL16_RS16565	COG1472	Belongs to the glycosyl hydrolase 3 family
BFL16_RS16570	COG0277	FAD linked oxidase domain protein
BFL16_RS16575	COG1686	Belongs to the peptidase S11 family
BFL16_RS16585	COG0586	Pfam SNARE associated Golgi protein
BFL16_RS16590	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS16595	COG1538	Outer membrane efflux protein
BFL16_RS16610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BFL16_RS16615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFL16_RS16620	COG0625	glutathione transferase activity
BFL16_RS16635	COG2271	Major facilitator Superfamily
BFL16_RS16650	COG1346	cytolysis
BFL16_RS16660	COG2949	membrane
BFL16_RS16670	COG0493	'glutamate synthase
BFL16_RS16675	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BFL16_RS16675	COG0167	dihydroorotate dehydrogenase activity
BFL16_RS16680	COG4211	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS16685	COG1129	ABC transporter
BFL16_RS16690	COG1879	ABC-type sugar transport system periplasmic component
BFL16_RS16695	COG1609	Transcriptional regulator
BFL16_RS16705	COG2311	Membrane
BFL16_RS16720	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BFL16_RS16725	COG4771	TonB-dependent receptor
BFL16_RS16735	COG0833	amino acid
BFL16_RS16745	COG0583	DNA-binding transcription factor activity
BFL16_RS16750	COG2855	membrane
BFL16_RS16760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL16_RS16760	COG1522	sequence-specific DNA binding
BFL16_RS16765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BFL16_RS16775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFL16_RS16780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BFL16_RS16785	COG2313	pseudouridylate synthase activity
BFL16_RS16790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL16_RS16795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFL16_RS16795	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
BFL16_RS16795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFL16_RS16800	COG1105	Belongs to the carbohydrate kinase PfkB family
BFL16_RS16805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS16805	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS16810	COG2814	Major facilitator Superfamily
BFL16_RS16825	COG0246	Mannitol dehydrogenase
BFL16_RS16830	COG0523	cobalamin synthesis protein
BFL16_RS16835	COG0671	phosphoesterase, PA-phosphatase related
BFL16_RS16840	COG0791	NLP P60 protein
BFL16_RS16845	COG2200	EAL domain
BFL16_RS16850	COG4166	transmembrane transport
BFL16_RS16855	COG4174	ABC transporter (Permease)
BFL16_RS16860	COG4239	(ABC) transporter, permease
BFL16_RS16865	COG4172	Belongs to the ABC transporter superfamily
BFL16_RS16880	COG2814	Major facilitator Superfamily
BFL16_RS16885	COG1187	pseudouridine synthase activity
BFL16_RS16895	COG1061	Type III restriction enzyme res subunit
BFL16_RS16915	COG3083	sulfuric ester hydrolase activity
BFL16_RS16925	COG3468	outer membrane autotransporter barrel domain protein
BFL16_RS16935	COG2197	response regulator
BFL16_RS16940	COG3088	subunit of a heme lyase
BFL16_RS16940	COG4235	cytochrome complex assembly
BFL16_RS16945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BFL16_RS16950	COG1138	Cytochrome C-type biogenesis protein
BFL16_RS16960	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFL16_RS16965	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFL16_RS16970	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFL16_RS16975	COG4133	protoheme IX ABC transporter activity
BFL16_RS16980	COG3005	denitrification pathway
BFL16_RS16985	COG3043	anaerobic respiration
BFL16_RS16990	COG0348	domain, Protein
BFL16_RS16995	COG0437	4 iron, 4 sulfur cluster binding
BFL16_RS17005	COG3062	negative regulation of establishment of protein localization
BFL16_RS17010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS17010	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS17030	COG4615	Cyclic peptide transporter
BFL16_RS17035	COG3145	DNA-N1-methyladenine dioxygenase activity
BFL16_RS17040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BFL16_RS17040	COG2169	Transcriptional regulator
BFL16_RS17045	COG1477	protein flavinylation
BFL16_RS17050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BFL16_RS17065	COG2198	Histidine kinase
BFL16_RS17065	COG0642	Histidine kinase
BFL16_RS17070	COG2197	response regulator
BFL16_RS17080	COG2205	protein histidine kinase activity
BFL16_RS17080	COG0784	Response regulator, receiver
BFL16_RS17085	COG4676	Protein conserved in bacteria
BFL16_RS17100	COG3234	Protein of unknown function (DUF1175)
BFL16_RS17105	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
BFL16_RS17110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BFL16_RS17120	COG3468	outer membrane autotransporter barrel domain protein
BFL16_RS17130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BFL16_RS17135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BFL16_RS17140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFL16_RS17145	COG3642	lipopolysaccharide core region biosynthetic process
BFL16_RS17150	COG2814	Major facilitator Superfamily
BFL16_RS17155	COG0583	DNA-binding transcription factor activity
BFL16_RS17165	COG0584	glycerophosphoryl diester phosphodiesterase
BFL16_RS17170	COG2271	Major facilitator Superfamily
BFL16_RS17175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BFL16_RS17185	COG0247	lactate metabolic process
BFL16_RS17190	COG5464	transposase or invertase
BFL16_RS17195	COG3836	Belongs to the HpcH HpaI aldolase family
BFL16_RS17200	COG2271	Major facilitator Superfamily
BFL16_RS17205	COG4948	Mandelate Racemase Muconate Lactonizing
BFL16_RS17210	COG1414	Transcriptional regulator
BFL16_RS17230	COG0406	alpha-ribazole phosphatase activity
BFL16_RS17275	COG0318	PFAM AMP-dependent synthetase and ligase
BFL16_RS17285	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BFL16_RS17300	COG1169	isochorismate synthase
BFL16_RS17305	COG4575	ribosome binding
BFL16_RS17310	COG2153	protein acetylation
BFL16_RS17315	COG1234	tRNA 3'-trailer cleavage
BFL16_RS17320	COG5160	protein modification by small protein removal
BFL16_RS17330	COG2234	aminopeptidase activity
BFL16_RS17335	COG2234	aminopeptidase activity
BFL16_RS17350	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFL16_RS17355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BFL16_RS17365	COG0839	Belongs to the complex I subunit 6 family
BFL16_RS17380	COG1034	ATP synthesis coupled electron transport
BFL16_RS17385	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BFL16_RS17390	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BFL16_RS17410	COG0583	DNA-binding transcription factor activity
BFL16_RS17420	COG0436	Aminotransferase
BFL16_RS17430	COG0490	domain, Protein
BFL16_RS17430	COG0471	metal ion transport
BFL16_RS17435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFL16_RS17455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BFL16_RS17460	COG0857	belongs to the CobB CobQ family
BFL16_RS17460	COG0280	phosphate acetyltransferase
BFL16_RS17465	COG1288	antiporter activity
BFL16_RS17470	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BFL16_RS17475	COG0622	Phosphoesterase
BFL16_RS17480	COG0625	glutathione transferase activity
BFL16_RS17485	COG0625	glutathione transferase activity
BFL16_RS17490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BFL16_RS17495	COG1090	epimerase
BFL16_RS17500	COG5464	transposase or invertase
BFL16_RS17505	COG4598	ABC transporter
BFL16_RS17510	COG4160	amino acid transport
BFL16_RS17515	COG4215	(ABC) transporter
BFL16_RS17520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL16_RS17525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL16_RS17530	COG0163	prenyltransferase activity
BFL16_RS17535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BFL16_RS17540	COG1286	toxin biosynthetic process
BFL16_RS17555	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
BFL16_RS17560	COG0285	dihydrofolate synthase activity
BFL16_RS17570	COG0586	Pfam SNARE associated Golgi protein
BFL16_RS17580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BFL16_RS17595	COG2814	Major facilitator Superfamily
BFL16_RS17605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFL16_RS17610	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BFL16_RS17610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFL16_RS17620	COG3101	peptidyl-lysine hydroxylation
BFL16_RS17625	COG0730	response to heat
BFL16_RS17660	COG3539	Fimbrial protein
BFL16_RS17665	COG3539	Fimbrial protein
BFL16_RS17670	COG3539	Fimbrial protein
BFL16_RS17675	COG3121	Chaperone
BFL16_RS17680	COG3188	usher protein
BFL16_RS17685	COG3539	Fimbrial protein
BFL16_RS17690	COG2062	phosphohistidine phosphatase, SixA
BFL16_RS17705	COG3691	Protein conserved in bacteria
BFL16_RS17715	COG2067	long-chain fatty acid transport protein
BFL16_RS17735	COG2853	Lipoprotein
BFL16_RS17740	COG2116	formate transmembrane transporter activity
BFL16_RS17895	COG3772	lysozyme
BFL16_RS17935	COG4372	Transposase
BFL16_RS17940	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS18070	COG2815	serine threonine protein kinase
BFL16_RS18070	COG0515	serine threonine protein kinase
BFL16_RS18220	COG0582	viral genome integration into host DNA
BFL16_RS18290	COG2610	gluconate transmembrane transporter activity
BFL16_RS18300	COG0477	Major facilitator Superfamily
BFL16_RS18305	COG1566	PFAM secretion protein HlyD family protein
BFL16_RS18310	COG2197	response regulator
BFL16_RS18315	COG2198	Histidine kinase
BFL16_RS18315	COG0784	Response regulator, receiver
BFL16_RS18315	COG2205	protein histidine kinase activity
BFL16_RS18315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL16_RS18320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFL16_RS18325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFL16_RS18330	COG0679	Auxin Efflux Carrier
BFL16_RS18335	COG0028	Belongs to the TPP enzyme family
BFL16_RS18365	COG1560	Kdo2-lipid A biosynthetic process
BFL16_RS18375	COG0436	Aminotransferase
BFL16_RS18380	COG3275	phosphorelay sensor kinase activity
BFL16_RS18385	COG3279	Response regulator of the LytR AlgR family
BFL16_RS18390	COG2207	Transcriptional regulator
BFL16_RS18395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFL16_RS18395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS18395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS18400	COG1363	Peptidase, m42
BFL16_RS18405	COG0006	proline dipeptidase activity
BFL16_RS18410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFL16_RS18415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFL16_RS18445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BFL16_RS18450	COG2199	diguanylate cyclase activity
BFL16_RS18450	COG2200	EAL domain
BFL16_RS18465	COG3415	Transposase
BFL16_RS18470	COG3415	Transposase
BFL16_RS18475	COG0675	Transposase, IS605 OrfB family
BFL16_RS18485	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS18490	COG4372	Transposase
BFL16_RS18495	COG0675	Transposase, IS605 OrfB family
BFL16_RS18535	COG0583	DNA-binding transcription factor activity
BFL16_RS18540	COG0385	Bile acid
BFL16_RS18545	COG3530	Putative quorum-sensing-regulated virulence factor
BFL16_RS18570	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BFL16_RS18575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS18580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFL16_RS18585	COG2190	(PTS) system
BFL16_RS18600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BFL16_RS18605	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BFL16_RS18610	COG4208	sulfate ABC transporter
BFL16_RS18615	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BFL16_RS18620	COG4150	thiosulfate binding
BFL16_RS18625	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS18640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFL16_RS18640	COG1263	PTS System
BFL16_RS18645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BFL16_RS18650	COG2837	iron assimilation
BFL16_RS18670	COG0860	N-Acetylmuramoyl-L-alanine amidase
BFL16_RS18680	COG2207	Transcriptional regulator
BFL16_RS18685	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BFL16_RS18690	COG4816	utilization protein
BFL16_RS18700	COG4303	Ethanolamine ammonia lyase large subunit
BFL16_RS18705	COG4819	ethanolamine utilization protein
BFL16_RS18710	COG3192	ethanolamine utilization protein
BFL16_RS18715	COG1454	alcohol dehydrogenase
BFL16_RS18720	COG4820	ethanolamine utilization protein (EutJ)
BFL16_RS18725	COG1012	belongs to the aldehyde dehydrogenase family
BFL16_RS18730	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
BFL16_RS18735	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
BFL16_RS18740	COG0280	phosphate acetyltransferase
BFL16_RS18745	COG4812	Cobalamin adenosyltransferase
BFL16_RS18750	COG4766	ethanolamine catabolic process
BFL16_RS18755	COG4917	ethanolamine utilization protein
BFL16_RS18760	COG4810	utilization protein
BFL16_RS18770	COG0280	phosphate acetyltransferase
BFL16_RS18770	COG0281	malic enzyme
BFL16_RS18775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BFL16_RS18780	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BFL16_RS18785	COG5342	invasion associated locus B
BFL16_RS18795	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS18795	COG0493	'glutamate synthase
BFL16_RS18800	COG3850	Histidine kinase
BFL16_RS18805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFL16_RS18820	COG1393	Belongs to the ArsC family
BFL16_RS18835	COG0400	carboxylic ester hydrolase activity
BFL16_RS18845	COG2321	neutral zinc metallopeptidase
BFL16_RS18860	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BFL16_RS18870	COG2716	regulation of RNA biosynthetic process
BFL16_RS18875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BFL16_RS18880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS18890	COG0650	Formate hydrogenlyase subunit 4
BFL16_RS18895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BFL16_RS18900	COG4237	Hydrogenase 4 membrane
BFL16_RS18905	COG0651	ATP synthesis coupled electron transport
BFL16_RS18910	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BFL16_RS18910	COG3261	NADH dehydrogenase
BFL16_RS18915	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFL16_RS18920	COG3260	NADH ubiquinone oxidoreductase 20
BFL16_RS18930	COG3604	Transcriptional regulator
BFL16_RS18935	COG2116	formate transmembrane transporter activity
BFL16_RS18940	COG0628	permease
BFL16_RS18945	COG4783	chaperone-mediated protein folding
BFL16_RS18950	COG1393	Belongs to the ArsC family
BFL16_RS18960	COG2233	PERMEase
BFL16_RS18980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BFL16_RS18985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BFL16_RS18990	COG0248	Ppx GppA phosphatase
BFL16_RS18995	COG2200	EAL domain
BFL16_RS19015	COG3133	Outer membrane lipoprotein
BFL16_RS19030	COG0516	GMP reductase activity
BFL16_RS19030	COG0517	IMP dehydrogenase activity
BFL16_RS19040	COG1645	bacterial-type flagellum-dependent swarming motility
BFL16_RS19055	COG2976	Protein conserved in bacteria
BFL16_RS19090	COG3302	dmso reductase anchor subunit
BFL16_RS19095	COG0437	4 iron, 4 sulfur cluster binding
BFL16_RS19100	COG0243	molybdopterin cofactor binding
BFL16_RS19105	COG4953	penicillin-binding protein 1C
BFL16_RS19110	COG2373	Large extracellular alpha-helical protein
BFL16_RS19115	COG2897	thiosulfate sulfurtransferase activity
BFL16_RS19130	COG2975	iron-sulfur cluster assembly
BFL16_RS19135	COG0633	Ferredoxin
BFL16_RS19155	COG0822	iron-sulfur transferase activity
BFL16_RS19175	COG0483	inositol monophosphate 1-phosphatase activity
BFL16_RS19180	COG1073	alpha beta
BFL16_RS19185	COG3711	transcriptional antiterminator
BFL16_RS19190	COG2814	Major facilitator Superfamily
BFL16_RS19195	COG0583	DNA-binding transcription factor activity
BFL16_RS19200	COG4638	Rieske (2fe-2S)
BFL16_RS19225	COG2259	Doxx family
BFL16_RS19230	COG2017	converts alpha-aldose to the beta-anomer
BFL16_RS19240	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS19245	COG1129	ABC transporter
BFL16_RS19250	COG1879	ABC-type sugar transport system periplasmic component
BFL16_RS19255	COG0457	Tetratricopeptide repeat
BFL16_RS19260	COG1940	carbohydrate kinase activity
BFL16_RS19275	COG1017	nitric oxide dioxygenase activity
BFL16_RS19275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFL16_RS19280	COG0347	Belongs to the P(II) protein family
BFL16_RS19285	COG2204	response regulator
BFL16_RS19290	COG3170	Tfp pilus assembly protein FimV
BFL16_RS19295	COG2205	protein histidine kinase activity
BFL16_RS19300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BFL16_RS19300	COG0047	phosphoribosylformylglycinamidine synthase activity
BFL16_RS19310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BFL16_RS19315	COG0590	tRNA wobble adenosine to inosine editing
BFL16_RS19320	COG0560	Phosphoserine phosphatase
BFL16_RS19325	COG1737	Transcriptional regulator
BFL16_RS19330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS19350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BFL16_RS19375	COG0681	Belongs to the peptidase S26 family
BFL16_RS19385	COG3086	response to oxidative stress
BFL16_RS19390	COG3026	antisigma factor binding
BFL16_RS19395	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
BFL16_RS19400	COG1595	DNA-templated transcription, initiation
BFL16_RS19410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BFL16_RS19415	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BFL16_RS19420	COG0513	Belongs to the DEAD box helicase family
BFL16_RS19425	COG0583	DNA-binding transcription factor activity
BFL16_RS19430	COG1280	lysine exporter protein (LysE YggA)
BFL16_RS19445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFL16_RS19450	COG3118	belongs to the thioredoxin family
BFL16_RS19455	COG3148	PFAM DTW domain containing protein
BFL16_RS19460	COG0045	succinate-CoA ligase (ADP-forming) activity
BFL16_RS19460	COG1042	CoA-binding domain protein
BFL16_RS19460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFL16_RS19465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BFL16_RS19470	COG5544	Lipoprotein
BFL16_RS19475	COG0477	Major facilitator Superfamily
BFL16_RS19505	COG0542	response to heat
BFL16_RS19515	COG0564	pseudouridine synthase activity
BFL16_RS19520	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFL16_RS19530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BFL16_RS19535	COG0077	Prephenate dehydratase
BFL16_RS19535	COG1605	Chorismate mutase
BFL16_RS19540	COG0287	Prephenate dehydrogenase
BFL16_RS19540	COG1605	Chorismate mutase
BFL16_RS19545	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BFL16_RS19560	COG2199	diguanylate cyclase activity
BFL16_RS19565	COG2885	chlorophyll binding
BFL16_RS19590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BFL16_RS19595	COG4137	Cytochrome C assembly protein
BFL16_RS19600	COG4536	flavin adenine dinucleotide binding
BFL16_RS19620	COG0497	DNA recombination
BFL16_RS19625	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFL16_RS19635	COG2867	negative regulation of translational initiation
BFL16_RS19660	COG0727	PFAM Uncharacterised protein family (UPF0153)
BFL16_RS19720	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS19730	COG3772	lysozyme
BFL16_RS19780	COG2963	transposase activity
BFL16_RS19785	COG2826	transposase and inactivated derivatives, IS30 family
BFL16_RS19860	COG3468	outer membrane autotransporter barrel domain protein
BFL16_RS19865	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BFL16_RS19905	COG0579	oxidoreductase
BFL16_RS19910	COG1012	belongs to the aldehyde dehydrogenase family
BFL16_RS19915	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BFL16_RS19920	COG1113	amino acid transport
BFL16_RS19925	COG1802	Transcriptional regulator
BFL16_RS19930	COG1652	LysM domain
BFL16_RS19935	COG0401	homolog of Blt101
BFL16_RS19940	COG0640	Transcriptional regulator
BFL16_RS19945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BFL16_RS19950	COG2916	Histone family protein nucleoid-structuring protein H-NS
BFL16_RS19965	COG4575	ribosome binding
BFL16_RS19975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BFL16_RS19985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BFL16_RS19995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BFL16_RS20000	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BFL16_RS20010	COG4175	Glycine betaine
BFL16_RS20015	COG4176	ABC-type proline glycine betaine transport system permease component
BFL16_RS20020	COG2113	Glycine betaine
BFL16_RS20025	COG2814	Major facilitator Superfamily
BFL16_RS20030	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BFL16_RS20040	COG1846	Transcriptional regulator
BFL16_RS20045	COG1566	PFAM secretion protein HlyD family protein
BFL16_RS20050	COG2814	Major facilitator Superfamily
BFL16_RS20065	COG1238	metal cluster binding
BFL16_RS20070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFL16_RS20100	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BFL16_RS20105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BFL16_RS20125	COG1546	Belongs to the CinA family
BFL16_RS20130	COG2951	lytic endotransglycosylase activity
BFL16_RS20150	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS20155	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS20160	COG1349	DNA-binding transcription factor activity
BFL16_RS20165	COG0517	IMP dehydrogenase activity
BFL16_RS20165	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BFL16_RS20190	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BFL16_RS20195	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS20200	COG1609	Transcriptional regulator
BFL16_RS20205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFL16_RS20205	COG1263	PTS System
BFL16_RS20210	COG2723	6-phospho-beta-galactosidase activity
BFL16_RS20215	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BFL16_RS20225	COG3260	NADH ubiquinone oxidoreductase 20
BFL16_RS20230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFL16_RS20235	COG3261	NADH dehydrogenase
BFL16_RS20235	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
BFL16_RS20240	COG0650	Formate hydrogenlyase subunit 4
BFL16_RS20245	COG0651	ATP synthesis coupled electron transport
BFL16_RS20250	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS20265	COG0375	protein maturation
BFL16_RS20270	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BFL16_RS20275	COG0298	carbon dioxide binding
BFL16_RS20280	COG0409	Hydrogenase expression formation protein
BFL16_RS20285	COG0309	Hydrogenase expression formation protein (HypE)
BFL16_RS20290	COG3604	Transcriptional regulator
BFL16_RS20305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BFL16_RS20315	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BFL16_RS20320	COG0163	prenyltransferase activity
BFL16_RS20325	COG1846	Transcriptional regulator
BFL16_RS20330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFL16_RS20335	COG4942	peptidase
BFL16_RS20335	COG1388	LysM domain
BFL16_RS20390	COG2234	aminopeptidase activity
BFL16_RS20395	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BFL16_RS20400	COG1518	maintenance of DNA repeat elements
BFL16_RS20415	COG1857	crispr-associated protein
BFL16_RS20430	COG1203	CRISPR-associated helicase, Cas3
BFL16_RS20455	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BFL16_RS20460	COG0720	synthase
BFL16_RS20465	COG0644	oxidoreductase
BFL16_RS20470	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
BFL16_RS20475	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BFL16_RS20480	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BFL16_RS20485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BFL16_RS20490	COG2086	electron transfer activity
BFL16_RS20500	COG0277	FAD linked oxidase domain protein
BFL16_RS20505	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS20510	COG2223	nitrite transmembrane transporter activity
BFL16_RS20515	COG1070	Carbohydrate kinase
BFL16_RS20525	COG0602	queuosine metabolic process
BFL16_RS20535	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BFL16_RS20545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BFL16_RS20565	COG3956	TIGRFAM MazG family protein
BFL16_RS20570	COG2337	Toxic component of a toxin-antitoxin (TA) module
BFL16_RS20575	COG2336	PFAM SpoVT AbrB
BFL16_RS20580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BFL16_RS20585	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BFL16_RS20590	COG3850	Histidine kinase
BFL16_RS20590	COG2205	protein histidine kinase activity
BFL16_RS20590	COG3437	response regulator, receiver
BFL16_RS20590	COG4999	Histidine kinase
BFL16_RS20595	COG4948	Mandelate Racemase Muconate Lactonizing
BFL16_RS20600	COG4948	Mandelate Racemase Muconate Lactonizing
BFL16_RS20605	COG4948	Mandelate Racemase Muconate Lactonizing
BFL16_RS20610	COG2271	Major facilitator Superfamily
BFL16_RS20615	COG0716	FMN binding
BFL16_RS20620	COG0564	pseudouridine synthase activity
BFL16_RS20625	COG3098	single-species biofilm formation
BFL16_RS20645	COG1611	Belongs to the LOG family
BFL16_RS20650	COG0814	amino acid
BFL16_RS20655	COG1760	l-serine dehydratase
BFL16_RS20665	COG1454	alcohol dehydrogenase
BFL16_RS20670	COG0235	Class ii aldolase
BFL16_RS20675	COG0738	Major facilitator superfamily
BFL16_RS20685	COG1070	Carbohydrate kinase
BFL16_RS20695	COG1349	DNA-binding transcription factor activity
BFL16_RS20705	COG2363	Small membrane protein
BFL16_RS20710	COG0583	DNA-binding transcription factor activity
BFL16_RS20720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BFL16_RS20725	COG2166	iron-sulfur cluster assembly
BFL16_RS20730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BFL16_RS20735	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BFL16_RS20760	COG0860	N-Acetylmuramoyl-L-alanine amidase
BFL16_RS20765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BFL16_RS20765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BFL16_RS20770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BFL16_RS20775	COG1074	ATP-dependent DNA helicase activity
BFL16_RS20780	COG1025	Belongs to the peptidase M16 family
BFL16_RS20785	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BFL16_RS20790	COG4967	type IV pilus modification protein PilV
BFL16_RS20800	COG4795	General secretion pathway protein
BFL16_RS20805	COG2165	general secretion pathway protein
BFL16_RS20820	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BFL16_RS20845	COG0861	Integral membrane protein TerC family
BFL16_RS20855	COG0667	Aldo Keto reductase
BFL16_RS20875	COG1609	Transcriptional regulator
BFL16_RS20885	COG0583	DNA-binding transcription factor activity
BFL16_RS20890	COG1794	racemase activity, acting on amino acids and derivatives
BFL16_RS20895	COG2814	Major facilitator Superfamily
BFL16_RS20900	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS20910	COG0183	Belongs to the thiolase family
BFL16_RS20915	COG0814	amino acid
BFL16_RS20920	COG2771	luxR family
BFL16_RS20925	COG3710	Transcriptional regulator
BFL16_RS20955	COG0457	Tetratricopeptide repeat
BFL16_RS20965	COG3710	Transcriptional regulator
BFL16_RS20965	COG0457	Tetratricopeptide repeat
BFL16_RS20975	COG0741	lytic transglycosylase activity
BFL16_RS20980	COG2197	response regulator
BFL16_RS21095	COG2207	Transcriptional regulator
BFL16_RS21115	COG4942	peptidase
BFL16_RS21125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BFL16_RS21130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BFL16_RS21135	COG2080	2 iron, 2 sulfur cluster binding
BFL16_RS21140	COG3829	transcription factor binding
BFL16_RS21145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BFL16_RS21150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BFL16_RS21155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFL16_RS21165	COG0549	Belongs to the carbamate kinase family
BFL16_RS21170	COG3608	succinylglutamate desuccinylase aspartoacylase
BFL16_RS21170	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BFL16_RS21175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BFL16_RS21180	COG2068	MobA-Related Protein
BFL16_RS21185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS21185	COG0493	'glutamate synthase
BFL16_RS21190	COG0402	S-adenosylhomocysteine deaminase activity
BFL16_RS21195	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BFL16_RS21200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BFL16_RS21200	COG2080	2 iron, 2 sulfur cluster binding
BFL16_RS21205	COG2233	PERMEase
BFL16_RS21210	COG0402	S-adenosylhomocysteine deaminase activity
BFL16_RS21215	COG2252	PERMEase
BFL16_RS21220	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS21225	COG0493	'glutamate synthase
BFL16_RS21225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS21245	COG0493	'glutamate synthase
BFL16_RS21245	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS21255	COG2233	PERMEase
BFL16_RS21270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BFL16_RS21280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BFL16_RS21285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BFL16_RS21290	COG4974	Belongs to the 'phage' integrase family
BFL16_RS21295	COG0716	FMN binding
BFL16_RS21305	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BFL16_RS21315	COG1272	protein, Hemolysin III
BFL16_RS21325	COG2723	6-phospho-beta-galactosidase activity
BFL16_RS21345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFL16_RS21350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFL16_RS21355	COG0006	proline dipeptidase activity
BFL16_RS21380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BFL16_RS21395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFL16_RS21420	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFL16_RS21420	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFL16_RS21425	COG1703	isobutyryl-CoA mutase activity
BFL16_RS21430	COG1024	Enoyl-CoA hydratase
BFL16_RS21435	COG0427	acetyl-CoA hydrolase
BFL16_RS21440	COG0583	DNA-binding transcription factor activity
BFL16_RS21445	COG0583	DNA-binding transcription factor activity
BFL16_RS21450	COG2968	Membrane
BFL16_RS21460	COG0668	transmembrane transport
BFL16_RS21475	COG0191	fructose-bisphosphate aldolase activity
BFL16_RS21480	COG0126	phosphoglycerate kinase activity
BFL16_RS21510	COG1122	ATPase activity
BFL16_RS21515	COG1122	ATPase activity
BFL16_RS21520	COG1072	(Pantothenic acid kinase))
BFL16_RS21530	COG1494	fructose-1,6-bisphosphatase
BFL16_RS21535	COG1063	alcohol dehydrogenase
BFL16_RS21540	COG2213	PTS system mannitol-specific
BFL16_RS21545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS21550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BFL16_RS21555	COG0501	Belongs to the peptidase M48B family
BFL16_RS21570	COG1166	arginine decarboxylase activity
BFL16_RS21600	COG2814	Major facilitator Superfamily
BFL16_RS21605	COG3091	SprT-like family
BFL16_RS21610	COG2356	endonuclease I
BFL16_RS21615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BFL16_RS21620	COG0189	ligase activity
BFL16_RS21635	COG2805	Type II/IV secretion system protein
BFL16_RS21640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BFL16_RS21645	COG0762	integral membrane protein
BFL16_RS21655	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BFL16_RS21660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFL16_RS21670	COG0252	asparaginase activity
BFL16_RS21680	COG3171	Protein conserved in bacteria
BFL16_RS21695	COG1194	a g-specific adenine glycosylase
BFL16_RS21710	COG2211	Major facilitator Superfamily
BFL16_RS21715	COG1982	Orn Lys Arg decarboxylase major
BFL16_RS21725	COG1811	Na channel or pump
BFL16_RS21735	COG0582	viral genome integration into host DNA
BFL16_RS21740	COG4372	Transposase
BFL16_RS21755	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS21760	COG2433	Pfam Transposase IS66
BFL16_RS21870	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS21875	COG4372	Transposase
BFL16_RS21885	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS21895	COG2801	Transposase and inactivated derivatives
BFL16_RS21905	COG0306	phosphate transporter
BFL16_RS21915	COG0754	glutathionylspermidine amidase activity
BFL16_RS21920	COG0625	glutathione transferase activity
BFL16_RS21925	COG0298	carbon dioxide binding
BFL16_RS21930	COG0375	protein maturation
BFL16_RS21935	COG1773	rubredoxin
BFL16_RS21940	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BFL16_RS21945	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
BFL16_RS21950	COG5557	Pfam Polysulphide reductase, NrfD
BFL16_RS21955	COG0437	4 iron, 4 sulfur cluster binding
BFL16_RS21960	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BFL16_RS21980	COG0667	Aldo Keto reductase
BFL16_RS21990	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS22000	COG0848	biopolymer transport protein
BFL16_RS22005	COG0811	peptide transport
BFL16_RS22015	COG0626	cystathionine gamma-synthase activity
BFL16_RS22020	COG0586	Pfam SNARE associated Golgi protein
BFL16_RS22025	COG2207	Transcriptional regulator
BFL16_RS22035	COG1979	alcohol dehydrogenase
BFL16_RS22040	COG0656	L-ascorbic acid biosynthetic process
BFL16_RS22055	COG4238	major outer membrane lipoprotein
BFL16_RS22060	COG1032	radical SAM domain protein
BFL16_RS22065	COG2132	Multicopper oxidase
BFL16_RS22070	COG0204	Acyl-transferase
BFL16_RS22080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BFL16_RS22085	COG4166	transmembrane transport
BFL16_RS22090	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BFL16_RS22095	COG3111	PFAM Bacterial OB fold (BOF) protein
BFL16_RS22100	COG0745	RESPONSE REGULATOR receiver
BFL16_RS22105	COG0642	Histidine kinase
BFL16_RS22110	COG2249	NAD(P)H dehydrogenase (quinone) activity
BFL16_RS22115	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BFL16_RS22120	COG1737	Transcriptional regulator
BFL16_RS22130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFL16_RS22135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFL16_RS22140	COG1120	ATPase activity
BFL16_RS22145	COG4774	siderophore transport
BFL16_RS22150	COG0187	DNA topoisomerase II activity
BFL16_RS22155	COG3150	esterase
BFL16_RS22160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BFL16_RS22165	COG3151	Protein conserved in bacteria
BFL16_RS22170	COG0494	nUDIX hydrolase
BFL16_RS22175	COG1538	Outer membrane efflux protein
BFL16_RS22190	COG0754	glutathionylspermidine amidase activity
BFL16_RS22195	COG3384	dioxygenase
BFL16_RS22225	COG1585	Membrane protein implicated in regulation of membrane protease activity
BFL16_RS22230	COG2268	Band 7 protein
BFL16_RS22255	COG3025	triphosphatase activity
BFL16_RS22265	COG4991	sh3 domain protein
BFL16_RS22280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BFL16_RS22290	COG0583	DNA-binding transcription factor activity
BFL16_RS22300	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BFL16_RS22305	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BFL16_RS22310	COG0471	metal ion transport
BFL16_RS22325	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BFL16_RS22330	COG0358	DNA primase activity
BFL16_RS22340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFL16_RS22355	COG2375	cellular response to nickel ion
BFL16_RS22365	COG1695	Transcriptional regulator
BFL16_RS22370	COG0840	transmembrane signaling receptor activity
BFL16_RS22385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFL16_RS22395	COG1609	Transcriptional regulator
BFL16_RS22400	COG3250	beta-galactosidase activity
BFL16_RS22405	COG2731	YhcH YjgK YiaL family protein
BFL16_RS22410	COG0531	amino acid
BFL16_RS22420	COG3408	Glycogen debranching enzyme
BFL16_RS22420	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
BFL16_RS22425	COG1902	pentaerythritol trinitrate reductase activity
BFL16_RS22425	COG0446	pyridine nucleotide-disulphide oxidoreductase
BFL16_RS22430	COG5499	transcription regulator containing HTH domain
BFL16_RS22435	COG4680	protein conserved in bacteria
BFL16_RS22450	COG1451	nucleotide metabolic process
BFL16_RS22455	COG2949	membrane
BFL16_RS22460	COG0673	inositol 2-dehydrogenase activity
BFL16_RS22465	COG0861	Integral membrane protein TerC family
BFL16_RS22470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BFL16_RS22480	COG2721	sulfolactate sulfo-lyase activity
BFL16_RS22490	COG2271	Major facilitator Superfamily
BFL16_RS22495	COG2186	Transcriptional regulator
BFL16_RS22500	COG0586	Pfam SNARE associated Golgi protein
BFL16_RS22510	COG1422	Protein of unknown function (DUF1090)
BFL16_RS22515	COG4575	ribosome binding
BFL16_RS22520	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
BFL16_RS22530	COG2259	Doxx family
BFL16_RS22535	COG0435	Glutathione S-transferase
BFL16_RS22540	COG3152	Membrane
BFL16_RS22545	COG3152	Membrane
BFL16_RS22555	COG0583	DNA-binding transcription factor activity
BFL16_RS22560	COG1741	Belongs to the pirin family
BFL16_RS22575	COG0814	amino acid
BFL16_RS22580	COG1760	l-serine dehydratase
BFL16_RS22585	COG0251	oxidation-reduction process
BFL16_RS22590	COG1882	Formate acetyltransferase
BFL16_RS22595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BFL16_RS22605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BFL16_RS22610	COG0583	DNA-binding transcription factor activity
BFL16_RS22635	COG1929	Belongs to the glycerate kinase type-1 family
BFL16_RS22640	COG2084	Dehydrogenase
BFL16_RS22650	COG2271	Major facilitator Superfamily
BFL16_RS22655	COG2721	sulfolactate sulfo-lyase activity
BFL16_RS22660	COG2002	toxin-antitoxin pair type II binding
BFL16_RS22670	COG1349	DNA-binding transcription factor activity
BFL16_RS22685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFL16_RS22695	COG3716	PTS system mannose fructose sorbose family IID component
BFL16_RS22700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS22705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BFL16_RS22710	COG2222	sugar isomerase
BFL16_RS22720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFL16_RS22725	COG3715	PTS system
BFL16_RS22730	COG3716	PTS system mannose fructose sorbose family IID component
BFL16_RS22740	COG3539	Fimbrial protein
BFL16_RS22745	COG3121	Chaperone
BFL16_RS22750	COG3188	usher protein
BFL16_RS22755	COG3539	Fimbrial protein
BFL16_RS22780	COG3539	Fimbrial protein
BFL16_RS22785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BFL16_RS22805	COG2823	Periplasmic or secreted lipoprotein
BFL16_RS22810	COG0701	Predicted permease
BFL16_RS22815	COG0702	epimerase
BFL16_RS22820	COG0693	protein deglycase activity
BFL16_RS22825	COG3787	Belongs to the UPF0306 family
BFL16_RS22835	COG3153	acetyltransferase
BFL16_RS22840	COG3154	lipid carrier protein
BFL16_RS22845	COG0826	peptidase U32
BFL16_RS22850	COG0826	peptidase U32
BFL16_RS22855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFL16_RS22860	COG0814	amino acid
BFL16_RS22870	COG0513	Belongs to the DEAD box helicase family
BFL16_RS22910	COG0195	Participates in both transcription termination and antitermination
BFL16_RS22930	COG2194	sulfuric ester hydrolase activity
BFL16_RS22945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BFL16_RS22955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BFL16_RS22960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFL16_RS22970	COG1534	Rna-binding protein
BFL16_RS22975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BFL16_RS22980	COG2027	D-alanyl-D-alanine carboxypeptidase
BFL16_RS22990	COG0697	spore germination
BFL16_RS23005	COG0142	geranyltranstransferase activity
BFL16_RS23010	COG3423	Transcriptional regulator
BFL16_RS23020	COG5007	Belongs to the BolA IbaG family
BFL16_RS23025	COG3113	response to antibiotic
BFL16_RS23030	COG2854	intermembrane phospholipid transfer
BFL16_RS23035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BFL16_RS23040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BFL16_RS23045	COG1127	ABC transporter
BFL16_RS23050	COG0530	calcium, potassium:sodium antiporter activity
BFL16_RS23055	COG0517	IMP dehydrogenase activity
BFL16_RS23055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BFL16_RS23060	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BFL16_RS23065	COG3117	lipopolysaccharide transmembrane transporter activity
BFL16_RS23070	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BFL16_RS23075	COG1137	ATPase activity
BFL16_RS23080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BFL16_RS23085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BFL16_RS23100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS23105	COG0515	serine threonine protein kinase
BFL16_RS23115	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
BFL16_RS23120	COG2198	Histidine kinase
BFL16_RS23120	COG0784	Response regulator, receiver
BFL16_RS23120	COG5002	protein histidine kinase activity
BFL16_RS23125	COG1242	4 iron, 4 sulfur cluster binding
BFL16_RS23135	COG0067	glutamate synthase
BFL16_RS23135	COG0069	glutamate synthase activity
BFL16_RS23135	COG0070	glutamate synthase
BFL16_RS23140	COG0493	'glutamate synthase
BFL16_RS23145	COG4804	nuclease activity
BFL16_RS23150	COG2731	YhcH YjgK YiaL family protein
BFL16_RS23185	COG3069	C4-dicarboxylate transmembrane transporter activity
BFL16_RS23190	COG2969	positive regulation of protein catabolic process
BFL16_RS23195	COG0625	glutathione transferase activity
BFL16_RS23210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BFL16_RS23215	COG3105	Protein conserved in bacteria
BFL16_RS23220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFL16_RS23225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFL16_RS23245	COG2732	(Barnase) inhibitor
BFL16_RS23265	COG0583	DNA-binding transcription factor activity
BFL16_RS23270	COG0312	modulator of DNA gyrase
BFL16_RS23275	COG3164	Protein of unknown function
BFL16_RS23280	COG1530	ribonuclease E activity
BFL16_RS23285	COG0424	maF-like protein
BFL16_RS23290	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BFL16_RS23295	COG1792	Involved in formation and maintenance of cell shape
BFL16_RS23300	COG1077	Cell shape determining protein MreB Mrl
BFL16_RS23315	COG2199	diguanylate cyclase activity
BFL16_RS23315	COG2200	EAL domain
BFL16_RS23320	COG0604	alcohol dehydrogenase
BFL16_RS23335	COG0511	ligase activity, forming carbon-carbon bonds
BFL16_RS23340	COG0439	Biotin carboxylase
BFL16_RS23345	COG3924	membrane
BFL16_RS23350	COG4145	pantothenate transmembrane transporter activity
BFL16_RS23360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BFL16_RS23370	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BFL16_RS23380	COG1309	transcriptional regulator
BFL16_RS23390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL16_RS23395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFL16_RS23400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFL16_RS23410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL16_RS23415	COG4597	amino acid ABC transporter
BFL16_RS23420	COG0765	amino acid transport
BFL16_RS23425	COG1126	abc transporter atp-binding protein
BFL16_RS23465	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BFL16_RS23480	COG0009	L-threonylcarbamoyladenylate synthase
BFL16_RS23485	COG0551	DNA topoisomerase type I activity
BFL16_RS23495	COG0758	DNA mediated transformation
BFL16_RS23515	COG0569	domain protein
BFL16_RS23525	COG3036	rescue of stalled ribosome
BFL16_RS23530	COG0789	Transcriptional regulator
BFL16_RS23570	COG0201	protein transport
BFL16_RS23660	COG0089	rRNA binding
BFL16_RS23740	COG2964	Protein conserved in bacteria
BFL16_RS23745	COG0545	Peptidyl-prolyl cis-trans isomerase
BFL16_RS23755	COG1047	Peptidyl-prolyl cis-trans
BFL16_RS23760	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
BFL16_RS23780	COG0488	(ABC) transporter
BFL16_RS23785	COG0429	hydrolase of the alpha beta-hydrolase fold
BFL16_RS23795	COG3954	Phosphoribulokinase
BFL16_RS23800	COG1765	OsmC-like protein
BFL16_RS23810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFL16_RS23815	COG1289	transmembrane transporter activity
BFL16_RS23820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFL16_RS23825	COG0512	Glutamine amidotransferase of anthranilate synthase
BFL16_RS23830	COG2184	nucleotidyltransferase activity
BFL16_RS23840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BFL16_RS23855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BFL16_RS23860	COG2146	nitrite reductase [NAD(P)H] activity
BFL16_RS23865	COG2116	formate transmembrane transporter activity
BFL16_RS23880	COG0531	amino acid
BFL16_RS23885	COG2222	sugar isomerase
BFL16_RS23895	COG1082	Xylose isomerase domain protein TIM barrel
BFL16_RS23900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL16_RS23905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL16_RS23910	COG2188	Transcriptional regulator
BFL16_RS23915	COG0180	Tryptophanyl-tRNA synthetase
BFL16_RS23920	COG0546	phosphoglycolate phosphatase activity
BFL16_RS23925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BFL16_RS23930	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BFL16_RS23935	COG3266	domain, Protein
BFL16_RS23950	COG4796	Type ii and iii secretion system protein
BFL16_RS23965	COG3166	PFAM Fimbrial assembly family protein
BFL16_RS23970	COG4972	Pilus assembly protein
BFL16_RS23975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BFL16_RS23980	COG0494	nUDIX hydrolase
BFL16_RS23990	COG1011	Hydrolase
BFL16_RS23995	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BFL16_RS24005	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
BFL16_RS24035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BFL16_RS24040	COG2183	response to ionizing radiation
BFL16_RS24050	COG1918	ferrous iron import across plasma membrane
BFL16_RS24055	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BFL16_RS24070	COG5464	transposase or invertase
BFL16_RS24080	COG1040	competence protein
BFL16_RS24090	COG2610	gluconate transmembrane transporter activity
BFL16_RS24095	COG1640	4-alpha-glucanotransferase
BFL16_RS24100	COG0058	SHG alpha-glucan phosphorylase activity
BFL16_RS24125	COG1690	Belongs to the RtcB family
BFL16_RS24130	COG4650	regulator
BFL16_RS24135	COG1349	DNA-binding transcription factor activity
BFL16_RS24150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BFL16_RS24165	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BFL16_RS24170	COG0058	SHG alpha-glucan phosphorylase activity
BFL16_RS24190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BFL16_RS24195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BFL16_RS24200	COG2095	MarC family integral membrane protein
BFL16_RS24215	COG2610	gluconate transmembrane transporter activity
BFL16_RS24220	COG3265	gluconokinase activity
BFL16_RS24225	COG1609	Transcriptional regulator
BFL16_RS24230	COG1741	Belongs to the pirin family
BFL16_RS24235	COG0673	inositol 2-dehydrogenase activity
BFL16_RS24245	COG1247	-acetyltransferase
BFL16_RS24260	COG0405	Gamma-glutamyltransferase
BFL16_RS24270	COG0584	glycerophosphoryl diester phosphodiesterase
BFL16_RS24275	COG3842	ATPase activity
BFL16_RS24285	COG1175	transmembrane transport
BFL16_RS24290	COG1653	transport
BFL16_RS24300	COG0410	ABC transporter
BFL16_RS24305	COG0411	ABC transporter
BFL16_RS24310	COG4177	L-phenylalanine transmembrane transporter activity
BFL16_RS24315	COG0559	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS24320	COG0683	leucine binding
BFL16_RS24330	COG0456	acetyltransferase
BFL16_RS24345	COG0683	leucine binding
BFL16_RS24350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFL16_RS24355	COG2177	Part of the ABC transporter FtsEX involved in
BFL16_RS24360	COG2884	Cell division ATP-binding protein ftsE
BFL16_RS24365	COG0552	protein localization to endoplasmic reticulum
BFL16_RS24370	COG0742	ribosomal rna small subunit methyltransferase
BFL16_RS24375	COG3776	membrane
BFL16_RS24385	COG3714	YhhN family
BFL16_RS24400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BFL16_RS24415	COG0628	permease
BFL16_RS24435	COG0204	Acyl-transferase
BFL16_RS24445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFL16_RS24465	COG1216	Glycosyl transferase, family 2
BFL16_RS24490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFL16_RS24500	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS24505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFL16_RS24510	COG2091	lysine biosynthetic process via aminoadipic acid
BFL16_RS24515	COG0747	negative chemotaxis
BFL16_RS24520	COG0601	transmembrane transport
BFL16_RS24525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFL16_RS24530	COG0444	Belongs to the ABC transporter superfamily
BFL16_RS24535	COG1124	(ABC) transporter
BFL16_RS24545	COG2188	Transcriptional regulator
BFL16_RS24555	COG3414	Phosphotransferase system galactitol-specific IIB component
BFL16_RS24560	COG3775	system Galactitol-specific IIC component
BFL16_RS24575	COG0191	fructose-bisphosphate aldolase activity
BFL16_RS24590	COG0842	Transport permease protein
BFL16_RS24595	COG1129	ABC transporter
BFL16_RS24595	COG0842	Transport permease protein
BFL16_RS24600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL16_RS24630	COG2081	HI0933 family
BFL16_RS24635	COG0306	phosphate transporter
BFL16_RS24645	COG0589	response to stress
BFL16_RS24655	COG3104	oligopeptide transport
BFL16_RS24665	COG0339	signal peptide processing
BFL16_RS24670	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BFL16_RS24675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFL16_RS24695	COG0640	Transcriptional regulator
BFL16_RS24700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BFL16_RS24705	COG1393	Belongs to the ArsC family
BFL16_RS24720	COG3065	identical protein binding
BFL16_RS24730	COG2197	response regulator
BFL16_RS24735	COG3720	iron ion transport
BFL16_RS24740	COG4771	TonB-dependent receptor
BFL16_RS24750	COG4558	Periplasmic binding protein
BFL16_RS24760	COG3721	Heme iron utilization protein
BFL16_RS24770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFL16_RS24775	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BFL16_RS24780	COG1285	pathogenesis
BFL16_RS24795	COG3247	response to pH
BFL16_RS24800	COG2771	luxR family
BFL16_RS24810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL16_RS24815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFL16_RS24825	COG2207	Transcriptional regulator
BFL16_RS24830	COG2207	Transcriptional regulator
BFL16_RS24835	COG0076	glutamate decarboxylase activity
BFL16_RS24840	COG1858	cytochrome C peroxidase
BFL16_RS24850	COG2197	response regulator
BFL16_RS24855	COG0583	DNA-binding transcription factor activity
BFL16_RS24860	COG1295	ribonuclease BN
BFL16_RS24865	COG0477	Major facilitator Superfamily
BFL16_RS24870	COG2982	Protein involved in outer membrane biogenesis
BFL16_RS24875	COG2200	EAL domain
BFL16_RS24890	COG0612	Peptidase, M16
BFL16_RS24910	COG2200	EAL domain
BFL16_RS24910	COG2199	diguanylate cyclase activity
BFL16_RS24915	COG3118	belongs to the thioredoxin family
BFL16_RS24915	COG0457	Tetratricopeptide repeat
BFL16_RS24920	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BFL16_RS24925	COG1215	transferase activity, transferring glycosyl groups
BFL16_RS24930	COG1215	transferase activity, transferring glycosyl groups
BFL16_RS24955	COG2194	sulfuric ester hydrolase activity
BFL16_RS24975	COG0814	amino acid
BFL16_RS24980	COG4608	Belongs to the ABC transporter superfamily
BFL16_RS24985	COG0444	Belongs to the ABC transporter superfamily
BFL16_RS24990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFL16_RS24995	COG0601	transmembrane transport
BFL16_RS25000	COG0747	negative chemotaxis
BFL16_RS25015	COG2194	sulfuric ester hydrolase activity
BFL16_RS25020	COG3539	Fimbrial protein
BFL16_RS25025	COG3539	Fimbrial protein
BFL16_RS25035	COG3121	Chaperone
BFL16_RS25040	COG3539	Fimbrial protein
BFL16_RS25045	COG2223	nitrite transmembrane transporter activity
BFL16_RS25055	COG5571	outer membrane autotransporter
BFL16_RS25060	COG2818	Glycosylase
BFL16_RS25065	COG0456	acetyltransferase
BFL16_RS25070	COG0243	molybdopterin cofactor binding
BFL16_RS25075	COG2885	chlorophyll binding
BFL16_RS25090	COG2944	sequence-specific DNA binding
BFL16_RS25095	COG1278	Cold shock
BFL16_RS25120	COG3274	enterobacterial common antigen metabolic process
BFL16_RS25125	COG4682	membrane
BFL16_RS25130	COG4682	membrane
BFL16_RS25135	COG1070	Carbohydrate kinase
BFL16_RS25145	COG4213	ABC transporter substrate-binding protein
BFL16_RS25155	COG4214	carbohydrate transport
BFL16_RS25160	COG1609	Transcriptional regulator
BFL16_RS25160	COG2207	Transcriptional regulator
BFL16_RS25165	COG2992	FlgJ-related protein
BFL16_RS25170	COG0366	Alpha amylase catalytic
BFL16_RS25175	COG3977	Valine--pyruvate aminotransferase
BFL16_RS25180	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BFL16_RS25185	COG1414	Transcriptional regulator
BFL16_RS25195	COG2211	Major facilitator Superfamily
BFL16_RS25205	COG3713	MltA-interacting MipA family protein
BFL16_RS25210	COG0583	DNA-binding transcription factor activity
BFL16_RS25215	COG1566	PFAM secretion protein HlyD family protein
BFL16_RS25225	COG1012	belongs to the aldehyde dehydrogenase family
BFL16_RS25235	COG1454	alcohol dehydrogenase
BFL16_RS25240	COG3276	selenocysteine insertion sequence binding
BFL16_RS25250	COG0625	glutathione transferase activity
BFL16_RS25255	COG3209	COG3209 Rhs family protein
BFL16_RS25260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BFL16_RS25285	COG1566	PFAM secretion protein HlyD family protein
BFL16_RS25295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS25295	COG2213	PTS system mannitol-specific
BFL16_RS25305	COG3722	fumarate hydratase activity
BFL16_RS25330	COG5295	Hep Hag repeat protein
BFL16_RS25340	COG1620	l-lactate permease
BFL16_RS25345	COG2186	Transcriptional regulator
BFL16_RS25355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BFL16_RS25360	COG1045	serine acetyltransferase
BFL16_RS25375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BFL16_RS25380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BFL16_RS25395	COG4942	peptidase
BFL16_RS25400	COG2861	carbohydrate metabolic process
BFL16_RS25415	COG0156	8-amino-7-oxononanoate synthase activity
BFL16_RS25430	COG0859	PFAM glycosyl transferase family 9
BFL16_RS25435	COG0859	PFAM glycosyl transferase family 9
BFL16_RS25455	COG3642	lipopolysaccharide core region biosynthetic process
BFL16_RS25465	COG0515	serine threonine protein kinase
BFL16_RS25470	COG0438	transferase activity, transferring glycosyl groups
BFL16_RS25475	COG0859	PFAM glycosyl transferase family 9
BFL16_RS25480	COG1519	Transferase
BFL16_RS25510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BFL16_RS25540	COG1561	YicC-like family, N-terminal region
BFL16_RS25545	COG3645	SOS response
BFL16_RS25550	COG2860	membrane
BFL16_RS25560	COG0194	GDP metabolic process
BFL16_RS25570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BFL16_RS25575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFL16_RS25580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BFL16_RS25590	COG0786	glutamate:sodium symporter activity
BFL16_RS25595	COG2233	PERMEase
BFL16_RS25600	COG2982	Protein involved in outer membrane biogenesis
BFL16_RS25605	COG1501	Belongs to the glycosyl hydrolase 31 family
BFL16_RS25610	COG2211	Major facilitator Superfamily
BFL16_RS25620	COG0582	viral genome integration into host DNA
BFL16_RS25700	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS25705	COG4372	Transposase
BFL16_RS25760	COG5492	domain, Protein
BFL16_RS25930	COG0697	spore germination
BFL16_RS25935	COG1464	Belongs to the NlpA lipoprotein family
BFL16_RS25950	COG2814	Major facilitator Superfamily
BFL16_RS25975	COG2252	PERMEase
BFL16_RS25980	COG2252	PERMEase
BFL16_RS25990	COG2271	Major facilitator Superfamily
BFL16_RS25995	COG2271	Major facilitator Superfamily
BFL16_RS26000	COG3851	Histidine kinase
BFL16_RS26005	COG2197	response regulator
BFL16_RS26025	COG0440	acetolactate synthase activity
BFL16_RS26030	COG0028	Belongs to the TPP enzyme family
BFL16_RS26060	COG2814	Major facilitator Superfamily
BFL16_RS26065	COG0641	radical SAM
BFL16_RS26075	COG2149	membrane
BFL16_RS26085	COG3119	arylsulfatase activity
BFL16_RS26090	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BFL16_RS26095	COG2207	Transcriptional regulator
BFL16_RS26110	COG2188	Transcriptional regulator
BFL16_RS26135	COG5645	(Lipo)protein
BFL16_RS26140	COG0823	Involved in the tonB-independent uptake of proteins
BFL16_RS26145	COG0644	oxidoreductase
BFL16_RS26155	COG0561	phosphatase activity
BFL16_RS26160	COG3753	Protein conserved in bacteria
BFL16_RS26165	COG0187	DNA topoisomerase II activity
BFL16_RS26175	COG0592	DNA-directed DNA polymerase activity
BFL16_RS26235	COG0814	amino acid
BFL16_RS26250	COG2091	lysine biosynthetic process via aminoadipic acid
BFL16_RS26255	COG0431	NADPH-dependent FMN reductase
BFL16_RS26260	COG2252	PERMEase
BFL16_RS26265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFL16_RS26305	COG0704	Plays a role in the regulation of phosphate uptake
BFL16_RS26310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BFL16_RS26315	COG0581	inorganic phosphate transmembrane transporter activity
BFL16_RS26320	COG0573	inorganic phosphate transmembrane transporter activity
BFL16_RS26325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BFL16_RS26335	COG3539	Fimbrial protein
BFL16_RS26360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BFL16_RS26410	COG3312	ion transport
BFL16_RS26425	COG0716	FMN binding
BFL16_RS26430	COG1522	sequence-specific DNA binding
BFL16_RS26450	COG3158	transport of potassium into the cell
BFL16_RS26460	COG1129	ABC transporter
BFL16_RS26465	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS26470	COG1879	ABC-type sugar transport system periplasmic component
BFL16_RS26475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL16_RS26480	COG1609	Transcriptional regulator
BFL16_RS26485	COG0477	Major facilitator Superfamily
BFL16_RS26490	COG2186	Transcriptional regulator
BFL16_RS26530	COG3085	chromosome segregation
BFL16_RS26535	COG0606	chelatase, subunit chli
BFL16_RS26550	COG3978	acetolactate synthase activity
BFL16_RS26555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BFL16_RS26565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BFL16_RS26570	COG0583	DNA-binding transcription factor activity
BFL16_RS26580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFL16_RS26585	COG3692	DNA binding
BFL16_RS26590	COG0210	DNA helicase
BFL16_RS26610	COG3118	belongs to the thioredoxin family
BFL16_RS26620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BFL16_RS26630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BFL16_RS26635	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
BFL16_RS26640	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BFL16_RS26645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BFL16_RS26650	COG1088	dTDP-glucose 4,6-dehydratase activity
BFL16_RS26655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BFL16_RS26660	COG0456	acetyltransferase
BFL16_RS26665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BFL16_RS26670	COG2244	polysaccharide biosynthetic process
BFL16_RS26690	COG1113	amino acid transport
BFL16_RS26725	COG0641	radical SAM
BFL16_RS26735	COG3119	arylsulfatase activity
BFL16_RS26740	COG3071	HemY protein
BFL16_RS26745	COG2959	enzyme of heme biosynthesis
BFL16_RS26750	COG1587	Uroporphyrinogen-III synthase
BFL16_RS26765	COG3072	Adenylate cyclase
BFL16_RS26780	COG5567	small periplasmic lipoprotein
BFL16_RS26790	COG3159	Protein conserved in bacteria
BFL16_RS26800	COG1011	Hydrolase
BFL16_RS26805	COG0210	DNA helicase
BFL16_RS26810	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
BFL16_RS26815	COG3698	Phosphodiester glycosidase
BFL16_RS26825	COG0598	Magnesium transport protein CorA
BFL16_RS26855	COG2962	Rard protein
BFL16_RS26860	COG2050	protein possibly involved in aromatic compounds catabolism
BFL16_RS26865	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
BFL16_RS26870	COG0514	ATP-dependent DNA helicase (RecQ)
BFL16_RS26875	COG1280	lysine exporter protein (LysE YggA)
BFL16_RS26880	COG1280	lysine exporter protein (LysE YggA)
BFL16_RS26885	COG2267	carboxylic ester hydrolase activity
BFL16_RS26890	COG0561	phosphatase activity
BFL16_RS26895	COG0697	spore germination
BFL16_RS26900	COG0583	DNA-binding transcription factor activity
BFL16_RS26910	COG0412	Dienelactone hydrolase
BFL16_RS26915	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
BFL16_RS26925	COG1322	Protein conserved in bacteria
BFL16_RS26935	COG3165	ubiquinone biosynthetic process from chorismate
BFL16_RS26945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFL16_RS26950	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFL16_RS26955	COG0805	protein transport
BFL16_RS26960	COG0084	hydrolase, TatD family'
BFL16_RS26965	COG0250	Participates in transcription elongation, termination and antitermination
BFL16_RS26970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BFL16_RS26975	COG0543	2 iron, 2 sulfur cluster binding
BFL16_RS26980	COG0183	Belongs to the thiolase family
BFL16_RS26995	COG1739	Uncharacterized protein family UPF0029
BFL16_RS27000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BFL16_RS27005	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
BFL16_RS27040	COG1763	Mo-molybdopterin cofactor biosynthetic process
BFL16_RS27045	COG0746	molybdenum cofactor guanylyltransferase activity
BFL16_RS27050	COG3084	Protein conserved in bacteria
BFL16_RS27055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BFL16_RS27060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BFL16_RS27065	COG5339	Protein conserved in bacteria
BFL16_RS27080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFL16_RS27080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFL16_RS27095	COG3078	GTPase activator activity
BFL16_RS27100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFL16_RS27110	COG2204	response regulator
BFL16_RS27115	COG3852	Histidine kinase
BFL16_RS27120	COG0174	glutamine synthetase
BFL16_RS27130	COG1217	gtp-binding protein TYPA
BFL16_RS27135	COG2188	Transcriptional regulator
BFL16_RS27140	COG1082	Xylose isomerase domain protein TIM barrel
BFL16_RS27145	COG2271	Major facilitator Superfamily
BFL16_RS27150	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BFL16_RS27155	COG2211	Major facilitator Superfamily
BFL16_RS27160	COG2211	Major facilitator Superfamily
BFL16_RS27165	COG1501	Belongs to the glycosyl hydrolase 31 family
BFL16_RS27175	COG2017	converts alpha-aldose to the beta-anomer
BFL16_RS27180	COG2942	2-epimerase
BFL16_RS27185	COG3684	Belongs to the aldolase LacD family
BFL16_RS27190	COG2084	Dehydrogenase
BFL16_RS27195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL16_RS27200	COG1349	DNA-binding transcription factor activity
BFL16_RS27205	COG1011	Hydrolase
BFL16_RS27220	COG0456	acetyltransferase
BFL16_RS27245	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BFL16_RS27250	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BFL16_RS27265	COG2864	formate dehydrogenase
BFL16_RS27270	COG0437	4 iron, 4 sulfur cluster binding
BFL16_RS27295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS27295	COG3711	transcriptional antiterminator
BFL16_RS27300	COG1363	Peptidase, m42
BFL16_RS27305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFL16_RS27305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFL16_RS27310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS27350	COG1917	Cupin 2, conserved barrel domain protein
BFL16_RS27350	COG4977	sequence-specific DNA binding
BFL16_RS27360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BFL16_RS27380	COG2258	MOSC domain
BFL16_RS27385	COG2205	protein histidine kinase activity
BFL16_RS27390	COG0745	RESPONSE REGULATOR receiver
BFL16_RS27395	COG3678	ATP-independent chaperone mediated protein folding
BFL16_RS27420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BFL16_RS27445	COG3152	Membrane
BFL16_RS27450	COG3691	Protein conserved in bacteria
BFL16_RS27455	COG0589	response to stress
BFL16_RS27465	COG1494	fructose-1,6-bisphosphatase
BFL16_RS27475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BFL16_RS27500	COG1575	Belongs to the MenA family. Type 1 subfamily
BFL16_RS27515	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BFL16_RS27520	COG1609	Transcriptional regulator
BFL16_RS27525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BFL16_RS27535	COG3209	COG3209 Rhs family protein
BFL16_RS27565	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
BFL16_RS27580	COG0626	cystathionine gamma-synthase activity
BFL16_RS27585	COG0527	aspartate kinase activity
BFL16_RS27585	COG0460	homoserine dehydrogenase
BFL16_RS27595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BFL16_RS27605	COG0697	spore germination
BFL16_RS27610	COG3738	Protein conserved in bacteria
BFL16_RS27615	COG0371	Dehydrogenase
BFL16_RS27620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BFL16_RS27625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS27625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFL16_RS27625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS27630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFL16_RS27635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFL16_RS27640	COG1882	Formate acetyltransferase
BFL16_RS27645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BFL16_RS27650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BFL16_RS27655	COG2207	Transcriptional regulator
BFL16_RS27660	COG2194	sulfuric ester hydrolase activity
BFL16_RS27675	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BFL16_RS27690	COG0583	DNA-binding transcription factor activity
BFL16_RS27700	COG1473	amidohydrolase
BFL16_RS27705	COG0477	Major facilitator Superfamily
BFL16_RS27710	COG1309	transcriptional regulator
BFL16_RS27720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BFL16_RS27725	COG4206	TonB-dependent receptor
BFL16_RS27730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BFL16_RS27760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BFL16_RS27765	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BFL16_RS27765	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BFL16_RS27810	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BFL16_RS27815	COG0250	Participates in transcription elongation, termination and antitermination
BFL16_RS27860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BFL16_RS27865	COG2022	thiamine diphosphate biosynthetic process
BFL16_RS27870	COG2104	thiamine diphosphate biosynthetic process
BFL16_RS27875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BFL16_RS27910	COG3068	Protein conserved in bacteria
BFL16_RS27925	COG3678	ATP-independent chaperone mediated protein folding
BFL16_RS27935	COG4191	Histidine kinase
BFL16_RS27940	COG2204	response regulator
BFL16_RS27945	COG0151	Belongs to the GarS family
BFL16_RS27980	COG0456	acetyltransferase
BFL16_RS27990	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BFL16_RS27995	COG2224	Isocitrate lyase
BFL16_RS28015	COG1414	Transcriptional regulator
BFL16_RS28020	COG0646	methionine synthase
BFL16_RS28020	COG1410	methionine synthase
BFL16_RS28025	COG1283	sodium-dependent phosphate transmembrane transporter activity
BFL16_RS28075	COG1187	pseudouridine synthase activity
BFL16_RS28085	COG0527	aspartate kinase activity
BFL16_RS28115	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFL16_RS28135	COG2814	Major facilitator Superfamily
BFL16_RS28135	COG0477	Major facilitator Superfamily
BFL16_RS28140	COG3833	ABC-type maltose transport systems, permease component
BFL16_RS28145	COG1175	transmembrane transport
BFL16_RS28150	COG2182	Extracellular solute-binding protein
BFL16_RS28160	COG3842	ATPase activity
BFL16_RS28175	COG1357	PFAM Pentapeptide repeats (8 copies)
BFL16_RS28205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BFL16_RS28215	COG0534	Mate efflux family protein
BFL16_RS28220	COG3237	CsbD-like
BFL16_RS28225	COG0735	belongs to the Fur family
BFL16_RS28240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BFL16_RS28280	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BFL16_RS28285	COG5532	Uncharacterized conserved protein (DUF2303)
BFL16_RS28300	COG5301	cellulose 1,4-beta-cellobiosidase activity
BFL16_RS28340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BFL16_RS28350	COG0604	alcohol dehydrogenase
BFL16_RS28355	COG0305	Participates in initiation and elongation during chromosome replication
BFL16_RS28360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BFL16_RS28365	COG1448	Aminotransferase
BFL16_RS28375	COG3700	Belongs to the class B bacterial acid phosphatase family
BFL16_RS28380	COG0432	Pfam Uncharacterised protein family UPF0047
BFL16_RS28385	COG2315	Protein conserved in bacteria
BFL16_RS28390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BFL16_RS28400	COG0629	single-stranded DNA binding
BFL16_RS28415	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BFL16_RS28420	COG2207	Transcriptional regulator
BFL16_RS28425	COG0789	Transcriptional regulator
BFL16_RS28445	COG2252	PERMEase
BFL16_RS28450	COG0025	NhaP-type Na H and K H
BFL16_RS28455	COG1357	PFAM Pentapeptide repeats (8 copies)
BFL16_RS28465	COG3162	membrane
BFL16_RS28470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFL16_RS28485	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BFL16_RS28490	COG0437	4 iron, 4 sulfur cluster binding
BFL16_RS28495	COG3301	Polysulphide reductase, NrfD
BFL16_RS28500	COG1138	Cytochrome C-type biogenesis protein
BFL16_RS28505	COG3088	subunit of a heme lyase
BFL16_RS28510	COG4235	cytochrome complex assembly
BFL16_RS28520	COG1301	dicarboxylic acid transport
BFL16_RS28525	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BFL16_RS28535	COG1538	Outer membrane efflux protein
BFL16_RS28540	COG1289	transmembrane transporter activity
BFL16_RS28545	COG1566	PFAM secretion protein HlyD family protein
BFL16_RS28555	COG2015	COG2015, Alkyl sulfatase and related hydrolases
BFL16_RS28565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL16_RS28585	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS28590	COG1129	ABC transporter
BFL16_RS28610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BFL16_RS28615	COG0456	acetyltransferase
BFL16_RS28620	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BFL16_RS28625	COG3454	Phosphonate metabolism
BFL16_RS28630	COG4778	phosphonate C-P lyase system protein PhnL
BFL16_RS28640	COG4107	phosphonate C-P lyase system protein PhnK
BFL16_RS28645	COG3627	carbon phosphorus lyase activity
BFL16_RS28650	COG3626	phosphonate metabolism
BFL16_RS28655	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
BFL16_RS28660	COG3624	Phosphonate C-P lyase system protein PhnG
BFL16_RS28665	COG2188	Transcriptional regulator
BFL16_RS28670	COG3639	organic phosphonate transmembrane transporter activity
BFL16_RS28675	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BFL16_RS28680	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BFL16_RS28685	COG2764	glyoxalase bleomycin resistance protein dioxygenase
BFL16_RS28695	COG2824	Alkylphosphonate utilization operon protein PhnA
BFL16_RS28705	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BFL16_RS28715	COG0477	Major facilitator Superfamily
BFL16_RS28725	COG0642	Histidine kinase
BFL16_RS28730	COG0745	RESPONSE REGULATOR receiver
BFL16_RS28735	COG2194	sulfuric ester hydrolase activity
BFL16_RS28740	COG0531	amino acid
BFL16_RS28745	COG2207	Transcriptional regulator
BFL16_RS28750	COG1982	Orn Lys Arg decarboxylase major
BFL16_RS28755	COG2169	Transcriptional regulator
BFL16_RS28765	COG1486	melibiose metabolic process
BFL16_RS28770	COG2211	Major facilitator Superfamily
BFL16_RS28775	COG3647	Membrane
BFL16_RS28780	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
BFL16_RS28780	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
BFL16_RS28785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BFL16_RS28800	COG4565	transcriptional regulatory protein
BFL16_RS28805	COG3290	protein histidine kinase activity
BFL16_RS28810	COG3592	Divergent 4Fe-4S mono-cluster
BFL16_RS28815	COG2388	GCN5-related N-acetyl-transferase
BFL16_RS28835	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BFL16_RS28840	COG3104	oligopeptide transport
BFL16_RS28845	COG1982	Orn Lys Arg decarboxylase major
BFL16_RS28850	COG0531	amino acid
BFL16_RS28860	COG3710	Transcriptional regulator
BFL16_RS28875	COG1309	transcriptional regulator
BFL16_RS28880	COG4232	protein-disulfide reductase activity
BFL16_RS28890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BFL16_RS28895	COG1027	Aspartate ammonia-lyase
BFL16_RS28905	COG3030	protein affecting phage T7 exclusion by the F plasmid
BFL16_RS28910	COG0531	amino acid
BFL16_RS28940	COG1509	lysine 2,3-aminomutase activity
BFL16_RS28950	COG5510	response to toxic substance
BFL16_RS28955	COG5510	response to toxic substance
BFL16_RS28960	COG2076	Multidrug Resistance protein
BFL16_RS28965	COG3040	lipid binding
BFL16_RS28970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BFL16_RS28985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BFL16_RS28990	COG1053	succinate dehydrogenase
BFL16_RS29000	COG0531	amino acid
BFL16_RS29005	COG3264	Mechanosensitive ion channel
BFL16_RS29005	COG1511	domain protein
BFL16_RS29020	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BFL16_RS29045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BFL16_RS29045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BFL16_RS29050	COG0802	atpase or kinase
BFL16_RS29055	COG0860	N-Acetylmuramoyl-L-alanine amidase
BFL16_RS29075	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BFL16_RS29080	COG0330	HflC and HflK could
BFL16_RS29085	COG0330	HflC and HflK could
BFL16_RS29090	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
BFL16_RS29105	COG0557	exoribonuclease II activity
BFL16_RS29110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFL16_RS29115	COG3789	protein conserved in bacteria
BFL16_RS29120	COG1842	Phage shock protein A
BFL16_RS29130	COG3766	membrane
BFL16_RS29135	COG5463	Belongs to the UPF0441 family
BFL16_RS29140	COG0754	glutathionylspermidine amidase activity
BFL16_RS29145	COG1960	acyl-CoA dehydrogenase activity
BFL16_RS29160	COG3650	response to hydrogen peroxide
BFL16_RS29165	COG1073	alpha beta
BFL16_RS29180	COG3037	sugar-specific permease SgaT UlaA
BFL16_RS29185	COG3414	Phosphotransferase system galactitol-specific IIB component
BFL16_RS29190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL16_RS29225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BFL16_RS29240	COG1309	transcriptional regulator
BFL16_RS29250	COG0675	Transposase, IS605 OrfB family
BFL16_RS29255	COG1309	transcriptional regulator
BFL16_RS29260	COG3061	Opacity-associated protein A
BFL16_RS29270	COG0545	Peptidyl-prolyl cis-trans isomerase
BFL16_RS29275	COG1113	amino acid transport
BFL16_RS29285	COG0697	spore germination
BFL16_RS29290	COG0702	epimerase
BFL16_RS29295	COG1733	regulation of RNA biosynthetic process
BFL16_RS29300	COG0737	Belongs to the 5'-nucleotidase family
BFL16_RS29305	COG1218	3'(2'),5'-bisphosphate nucleotidase
BFL16_RS29320	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
BFL16_RS29330	COG1253	flavin adenine dinucleotide binding
BFL16_RS29345	COG0729	surface antigen
BFL16_RS29350	COG2911	Protein conserved in bacteria
BFL16_RS29355	COG2105	PFAM AIG2 family protein
BFL16_RS29360	COG2336	PFAM SpoVT AbrB
BFL16_RS29365	COG2337	Toxic component of a toxin-antitoxin (TA) module
BFL16_RS29370	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BFL16_RS29375	COG1879	ABC-type sugar transport system periplasmic component
BFL16_RS29380	COG1129	ABC transporter
BFL16_RS29385	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS29390	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL16_RS29400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BFL16_RS29410	COG0312	modulator of DNA gyrase
BFL16_RS29415	COG3783	Cytochrome b(562)
BFL16_RS29420	COG0602	queuosine metabolic process
BFL16_RS29430	COG1328	CTP reductase activity
BFL16_RS29435	COG0366	Alpha amylase catalytic
BFL16_RS29440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFL16_RS29440	COG1263	PTS System
BFL16_RS29445	COG1609	Transcriptional regulator
BFL16_RS29450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BFL16_RS29455	COG0251	oxidation-reduction process
BFL16_RS29480	COG0251	oxidation-reduction process
BFL16_RS29485	COG1028	Short-chain dehydrogenase reductase Sdr
BFL16_RS29490	COG1309	transcriptional regulator
BFL16_RS29495	COG2731	YhcH YjgK YiaL family protein
BFL16_RS29505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BFL16_RS29510	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
BFL16_RS29515	COG0456	acetyltransferase
BFL16_RS29520	COG4269	membrane
BFL16_RS29530	COG2927	DNA polymerase III (CHI subunit)
BFL16_RS29545	COG0795	lipopolysaccharide-transporting ATPase activity
BFL16_RS29550	COG0795	lipopolysaccharide-transporting ATPase activity
BFL16_RS29560	COG0433	COG0433 Predicted ATPase
BFL16_RS29565	COG1064	alcohol dehydrogenase
BFL16_RS29665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BFL16_RS29675	COG1111	helicase
BFL16_RS29675	COG1205	dead DEAH box helicase
BFL16_RS29680	COG0210	DNA helicase
BFL16_RS29705	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
BFL16_RS29710	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BFL16_RS29720	COG0582	viral genome integration into host DNA
BFL16_RS29725	COG4974	Belongs to the 'phage' integrase family
BFL16_RS29740	COG3539	Fimbrial protein
BFL16_RS29745	COG3539	Fimbrial protein
BFL16_RS29750	COG3121	Chaperone
BFL16_RS29755	COG4372	Transposase
BFL16_RS29760	COG3436	PFAM IS66 Orf2 family protein
BFL16_RS29770	COG3188	usher protein
BFL16_RS29775	COG3539	Fimbrial protein
BFL16_RS29780	COG3539	Fimbrial protein
BFL16_RS29785	COG3539	Fimbrial protein
BFL16_RS29790	COG2610	gluconate transmembrane transporter activity
BFL16_RS29805	COG0246	Mannitol dehydrogenase
BFL16_RS29815	COG2186	Transcriptional regulator
BFL16_RS29840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BFL16_RS29845	COG0700	Nucleoside recognition
BFL16_RS29850	COG3366	ferrous iron transmembrane transporter activity
BFL16_RS29870	COG1470	cell adhesion involved in biofilm formation
BFL16_RS29870	COG1388	LysM domain
BFL16_RS29875	COG1388	LysM domain
BFL16_RS29875	COG2373	Large extracellular alpha-helical protein
BFL16_RS29875	COG4932	domain protein
BFL16_RS29880	COG0477	Major facilitator Superfamily
BFL16_RS29885	COG3204	pilus organization
BFL16_RS29900	COG1924	4 iron, 4 sulfur cluster binding
BFL16_RS29905	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
BFL16_RS29910	COG2733	membrane
BFL16_RS29915	COG2814	Major facilitator Superfamily
BFL16_RS29925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFL16_RS29935	COG5457	Domain of unknown function (DUF1127)
BFL16_RS29955	COG0732	type I restriction modification DNA specificity domain
BFL16_RS29980	COG0523	cobalamin synthesis protein
BFL16_RS29985	COG2879	small protein
BFL16_RS29990	COG1966	Carbon starvation protein
BFL16_RS30000	COG0840	transmembrane signaling receptor activity
BFL16_RS30005	COG2271	Major facilitator Superfamily
BFL16_RS30010	COG1802	Transcriptional regulator
BFL16_RS30015	COG1063	alcohol dehydrogenase
BFL16_RS30030	COG1484	DNA-dependent DNA replication
BFL16_RS30045	COG2966	Psort location CytoplasmicMembrane, score
BFL16_RS30050	COG2197	response regulator
BFL16_RS30055	COG2197	response regulator
BFL16_RS30060	COG4114	ferric iron reductase
BFL16_RS30085	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
BFL16_RS30090	COG0456	acetyltransferase
BFL16_RS30095	COG1011	Hydrolase
BFL16_RS30105	COG2823	Periplasmic or secreted lipoprotein
BFL16_RS30115	COG4667	esterase of the alpha-beta hydrolase superfamily
BFL16_RS30120	COG0084	hydrolase, TatD family'
BFL16_RS30130	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BFL16_RS30170	COG3726	membrane protein affecting hemolysin expression
BFL16_RS30170	COG0095	Lipoate-protein ligase
BFL16_RS30175	COG0560	Phosphoserine phosphatase
BFL16_RS30180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BFL16_RS30185	COG3172	ATPase kinase involved in NAD metabolism
BFL16_RS30185	COG1056	cytidyltransferase-related domain
BFL16_RS30195	COG0488	(ABC) transporter
BFL16_RS30205	COG0741	lytic transglycosylase activity
BFL16_RS30215	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BFL16_RS30225	COG3708	Transcriptional regulator
BFL16_RS30225	COG2207	Transcriptional regulator
BFL16_RS30230	COG3045	CreA protein
BFL16_RS30235	COG0745	RESPONSE REGULATOR receiver
BFL16_RS30240	COG2205	protein histidine kinase activity
BFL16_RS30245	COG4452	Inner membrane protein CreD
BFL16_RS30250	COG0745	RESPONSE REGULATOR receiver
BFL16_RS30265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BFL16_RS30285	COG0460	homoserine dehydrogenase
BFL16_RS30285	COG0527	aspartate kinase activity
BFL16_RS30295	COG0460	homoserine dehydrogenase
BFL16_RS30295	COG0527	aspartate kinase activity
BFL16_RS30390	COG3188	usher protein
BFL16_RS30400	COG3188	usher protein
BFL16_RS30465	COG0505	Belongs to the CarA family
BFL16_RS30680	COG1357	PFAM Pentapeptide repeats (8 copies)
BFL16_RS30790	COG0586	Pfam SNARE associated Golgi protein
BFL16_RS30830	COG0028	Belongs to the TPP enzyme family