locus-tag	class	description
APECO1_RS00010	COG0527	aspartate kinase activity
APECO1_RS00010	COG0460	homoserine dehydrogenase
APECO1_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APECO1_RS00040	COG1115	amino acid carrier protein
APECO1_RS00050	COG0521	Mo-molybdopterin cofactor biosynthetic process
APECO1_RS00060	COG1584	GPR1 FUN34 yaaH family protein
APECO1_RS00065	COG4735	regulation of single-species biofilm formation
APECO1_RS00095	COG3119	arylsulfatase activity
APECO1_RS00110	COG0583	DNA-binding transcription factor activity
APECO1_RS00125	COG0196	riboflavin kinase activity
APECO1_RS00140	COG1047	Peptidyl-prolyl cis-trans
APECO1_RS00175	COG0505	Belongs to the CarA family
APECO1_RS00180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APECO1_RS00245	COG0644	oxidoreductase
APECO1_RS00250	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
APECO1_RS00255	COG2271	Major facilitator Superfamily
APECO1_RS00270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APECO1_RS00300	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APECO1_RS00305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APECO1_RS00315	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APECO1_RS00320	COG0564	pseudouridine synthase activity
APECO1_RS00330	COG0417	DNA replication proofreading
APECO1_RS00335	COG0235	Class ii aldolase
APECO1_RS00350	COG4977	sequence-specific DNA binding
APECO1_RS00365	COG0586	Pfam SNARE associated Golgi protein
APECO1_RS00375	COG1178	ABC-type Fe3 transport system permease component
APECO1_RS00380	COG4143	(ABC) transporter
APECO1_RS00420	COG0583	DNA-binding transcription factor activity
APECO1_RS00425	COG0028	Belongs to the TPP enzyme family
APECO1_RS00430	COG0440	acetolactate synthase activity
APECO1_RS00440	COG1609	Transcriptional regulator
APECO1_RS00455	COG3116	cell division
APECO1_RS00460	COG0768	penicillin binding
APECO1_RS00465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APECO1_RS00470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APECO1_RS00485	COG0772	Belongs to the SEDS family
APECO1_RS00500	COG1181	Belongs to the D-alanine--D-alanine ligase family
APECO1_RS00505	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APECO1_RS00510	COG0849	cell division
APECO1_RS00515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APECO1_RS00535	COG0494	nUDIX hydrolase
APECO1_RS00550	COG0237	dephospho-CoA kinase activity
APECO1_RS00560	COG1459	type II secretion system
APECO1_RS00565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APECO1_RS00570	COG4969	Belongs to the N-Me-Phe pilin family
APECO1_RS00580	COG0157	Belongs to the NadC ModD family
APECO1_RS00585	COG3023	N-Acetylmuramoyl-L-alanine amidase
APECO1_RS00590	COG3725	Membrane protein required for beta-lactamase induction
APECO1_RS00595	COG1113	amino acid transport
APECO1_RS00600	COG3157	Type VI secretion system effector, Hcp
APECO1_RS00625	COG2186	Transcriptional regulator
APECO1_RS00630	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APECO1_RS00635	COG0508	dehydrogenase complex catalyzes the overall conversion of
APECO1_RS00640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APECO1_RS00645	COG3064	Membrane
APECO1_RS00650	COG1049	propionate catabolic process, 2-methylcitrate cycle
APECO1_RS00675	COG2132	Multicopper oxidase
APECO1_RS00680	COG4993	Dehydrogenase
APECO1_RS00685	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APECO1_RS00690	COG0288	reversible hydration of carbon dioxide
APECO1_RS00695	COG1131	(ABC) transporter
APECO1_RS00700	COG0842	Transport permease protein
APECO1_RS00705	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS00710	COG0726	polysaccharide deacetylase
APECO1_RS00720	COG5464	transposase or invertase
APECO1_RS00735	COG3539	Fimbrial protein
APECO1_RS00740	COG3539	Fimbrial protein
APECO1_RS00745	COG3539	Fimbrial protein
APECO1_RS00750	COG3539	Fimbrial protein
APECO1_RS00755	COG3188	usher protein
APECO1_RS00760	COG3121	Chaperone
APECO1_RS00765	COG3539	Fimbrial protein
APECO1_RS00770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APECO1_RS00775	COG0617	tRNA 3'-terminal CCA addition
APECO1_RS00780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APECO1_RS00785	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APECO1_RS00795	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
APECO1_RS00800	COG1643	Atp-dependent helicase
APECO1_RS00805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APECO1_RS00810	COG4774	siderophore transport
APECO1_RS00815	COG1120	ATPase activity
APECO1_RS00820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APECO1_RS00825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO1_RS00845	COG2860	membrane
APECO1_RS00850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APECO1_RS00865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APECO1_RS00870	COG3835	regulator
APECO1_RS00890	COG0024	Methionine aminopeptidase
APECO1_RS00915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APECO1_RS00920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APECO1_RS00925	COG0575	Belongs to the CDS family
APECO1_RS00930	COG0750	zinc metalloprotease
APECO1_RS00940	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
APECO1_RS00970	COG0587	DNA-directed DNA polymerase activity
APECO1_RS00980	COG1982	Orn Lys Arg decarboxylase major
APECO1_RS00985	COG0346	lactoylglutathione lyase activity
APECO1_RS00990	COG0037	tRNA processing
APECO1_RS00995	COG4568	rho-dependent transcription termination
APECO1_RS01005	COG4681	YaeQ
APECO1_RS01010	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APECO1_RS01015	COG3015	lipoprotein NlpE involved in copper resistance
APECO1_RS01020	COG0791	NLP P60 protein
APECO1_RS01030	COG1720	tRNA m6t6A37 methyltransferase activity
APECO1_RS01040	COG1464	Belongs to the NlpA lipoprotein family
APECO1_RS01045	COG2011	ABC-type metal ion transport system permease component
APECO1_RS01050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APECO1_RS01055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APECO1_RS01090	COG0656	L-ascorbic acid biosynthetic process
APECO1_RS01095	COG0583	DNA-binding transcription factor activity
APECO1_RS01105	COG2226	methyltransferase
APECO1_RS01110	COG0741	lytic transglycosylase activity
APECO1_RS01110	COG1388	LysM domain
APECO1_RS01120	COG2226	methyltransferase
APECO1_RS01130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APECO1_RS01230	COG3501	Rhs element vgr protein
APECO1_RS01250	COG5433	transposase activity
APECO1_RS01255	COG5433	transposase activity
APECO1_RS01270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APECO1_RS01280	COG1960	acyl-CoA dehydrogenase activity
APECO1_RS01290	COG0121	glutamine amidotransferase
APECO1_RS01295	COG3034	peptidoglycan biosynthetic process
APECO1_RS01300	COG0791	NLP P60 protein
APECO1_RS01305	COG1943	Transposase
APECO1_RS01325	COG2161	toxin-antitoxin pair type II binding
APECO1_RS01335	COG0454	-acetyltransferase
APECO1_RS01340	COG1690	Belongs to the RtcB family
APECO1_RS01345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APECO1_RS01350	COG2195	Cleaves the N-terminal amino acid of tripeptides
APECO1_RS01370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APECO1_RS01465	COG0582	viral genome integration into host DNA
APECO1_RS01495	COG3477	response to acidic pH
APECO1_RS01500	COG0727	PFAM Uncharacterised protein family (UPF0153)
APECO1_RS01550	COG1902	pentaerythritol trinitrate reductase activity
APECO1_RS01555	COG1073	alpha beta
APECO1_RS01560	COG0583	DNA-binding transcription factor activity
APECO1_RS01570	COG0667	Aldo Keto reductase
APECO1_RS01575	COG0656	L-ascorbic acid biosynthetic process
APECO1_RS01580	COG1388	LysM domain
APECO1_RS01585	COG3708	Transcriptional regulator
APECO1_RS01585	COG2207	Transcriptional regulator
APECO1_RS01590	COG0656	L-ascorbic acid biosynthetic process
APECO1_RS01595	COG3059	membrane
APECO1_RS01605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APECO1_RS01610	COG2207	Transcriptional regulator
APECO1_RS01615	COG0247	lactate metabolic process
APECO1_RS01625	COG1556	Lactate utilization protein
APECO1_RS01640	COG3468	outer membrane autotransporter barrel domain protein
APECO1_RS01650	COG2200	EAL domain
APECO1_RS01650	COG2771	luxR family
APECO1_RS01655	COG0582	viral genome integration into host DNA
APECO1_RS01680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APECO1_RS01690	COG2771	luxR family
APECO1_RS01690	COG2200	EAL domain
APECO1_RS01695	COG0583	DNA-binding transcription factor activity
APECO1_RS01705	COG0666	response to abiotic stimulus
APECO1_RS01715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APECO1_RS01720	COG1304	FMN binding
APECO1_RS01725	COG0549	Belongs to the carbamate kinase family
APECO1_RS01730	COG0402	S-adenosylhomocysteine deaminase activity
APECO1_RS01740	COG1879	ABC-type sugar transport system periplasmic component
APECO1_RS01745	COG1129	ABC transporter
APECO1_RS01750	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS01760	COG1064	alcohol dehydrogenase
APECO1_RS01770	COG1280	lysine exporter protein (LysE YggA)
APECO1_RS01780	COG3829	transcription factor binding
APECO1_RS01785	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
APECO1_RS01790	COG0372	Belongs to the citrate synthase family
APECO1_RS01795	COG2079	MmgE PrpD family protein
APECO1_RS01800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APECO1_RS01805	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APECO1_RS01810	COG0402	S-adenosylhomocysteine deaminase activity
APECO1_RS01815	COG0110	maltose O-acetyltransferase activity
APECO1_RS01820	COG2223	nitrite transmembrane transporter activity
APECO1_RS01830	COG1609	Transcriptional regulator
APECO1_RS01835	COG3122	Protein conserved in bacteria
APECO1_RS01865	COG1215	transferase activity, transferring glycosyl groups
APECO1_RS01870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APECO1_RS01875	COG4521	taurine ABC transporter
APECO1_RS01885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APECO1_RS01890	COG2175	clavaminate synthase activity
APECO1_RS01895	COG0113	porphobilinogen synthase activity
APECO1_RS01900	COG3468	outer membrane autotransporter barrel domain protein
APECO1_RS01905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APECO1_RS01910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
APECO1_RS01920	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
APECO1_RS01940	COG1181	Belongs to the D-alanine--D-alanine ligase family
APECO1_RS01950	COG1785	Belongs to the alkaline phosphatase family
APECO1_RS01960	COG3706	GGDEF domain
APECO1_RS01965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APECO1_RS01990	COG4126	flavin adenine dinucleotide binding
APECO1_RS02010	COG1940	carbohydrate kinase activity
APECO1_RS02015	COG2814	Major facilitator Superfamily
APECO1_RS02020	COG0419	ATPase involved in DNA repair
APECO1_RS02025	COG0420	3'-5' exonuclease activity
APECO1_RS02030	COG0745	RESPONSE REGULATOR receiver
APECO1_RS02035	COG5002	protein histidine kinase activity
APECO1_RS02040	COG1114	Component of the transport system for branched-chain amino acids
APECO1_RS02045	COG1113	amino acid transport
APECO1_RS02050	COG0366	Alpha amylase catalytic
APECO1_RS02070	COG1862	Preprotein translocase
APECO1_RS02075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APECO1_RS02080	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APECO1_RS02085	COG1403	HNH endonuclease
APECO1_RS02090	COG3248	Nucleoside-binding outer membrane protein
APECO1_RS02095	COG4238	major outer membrane lipoprotein
APECO1_RS02105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APECO1_RS02105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APECO1_RS02120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APECO1_RS02125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APECO1_RS02130	COG0667	Aldo Keto reductase
APECO1_RS02140	COG0142	geranyltranstransferase activity
APECO1_RS02155	COG0693	protein deglycase activity
APECO1_RS02160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APECO1_RS02170	COG2814	Major facilitator Superfamily
APECO1_RS02180	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APECO1_RS02185	COG1845	cytochrome c oxidase, subunit III
APECO1_RS02190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APECO1_RS02195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APECO1_RS02200	COG2223	nitrite transmembrane transporter activity
APECO1_RS02205	COG3056	Lipoprotein
APECO1_RS02210	COG0271	Belongs to the BolA IbaG family
APECO1_RS02235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APECO1_RS02240	COG0776	regulation of translation
APECO1_RS02245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APECO1_RS02250	COG1555	photosystem II stabilization
APECO1_RS02255	COG0824	Thioesterase
APECO1_RS02265	COG4533	DNA binding
APECO1_RS02275	COG1522	sequence-specific DNA binding
APECO1_RS02280	COG1132	(ABC) transporter
APECO1_RS02285	COG1132	(ABC) transporter
APECO1_RS02290	COG0347	Belongs to the P(II) protein family
APECO1_RS02295	COG0004	ammonium transporteR
APECO1_RS02300	COG1946	Acyl-CoA thioesterase
APECO1_RS02305	COG3126	Type III secretion system lipoprotein chaperone (YscW)
APECO1_RS02310	COG3695	enzyme binding
APECO1_RS02315	COG5507	3-demethylubiquinone-9 3-methyltransferase
APECO1_RS02320	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APECO1_RS02330	COG0110	maltose O-acetyltransferase activity
APECO1_RS02345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO1_RS02350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO1_RS02355	COG1309	transcriptional regulator
APECO1_RS02360	COG1196	nuclear chromosome segregation
APECO1_RS02360	COG3264	Mechanosensitive ion channel
APECO1_RS02375	COG3923	Primosomal replication protein n
APECO1_RS02380	COG2832	Protein of unknown function (DUF454)
APECO1_RS02390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APECO1_RS02425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO1_RS02430	COG4651	solute:proton antiporter activity
APECO1_RS02430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APECO1_RS02435	COG2223	nitrite transmembrane transporter activity
APECO1_RS02440	COG0737	Belongs to the 5'-nucleotidase family
APECO1_RS02455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APECO1_RS02460	COG3735	TraB family
APECO1_RS02465	COG3549	Plasmid maintenance system killer
APECO1_RS02470	COG3093	addiction module antidote protein HigA
APECO1_RS02475	COG2217	Heavy metal translocating P-type atpase
APECO1_RS02480	COG2066	Belongs to the glutaminase family
APECO1_RS02485	COG0531	amino acid
APECO1_RS02490	COG0789	Transcriptional regulator
APECO1_RS02515	COG1585	Membrane protein implicated in regulation of membrane protease activity
APECO1_RS02520	COG0330	HflC and HflK could
APECO1_RS02525	COG4619	ABC transporter
APECO1_RS02530	COG0390	transport system, permease component
APECO1_RS02535	COG3118	belongs to the thioredoxin family
APECO1_RS02540	COG0300	oxidoreductase activity
APECO1_RS02545	COG2755	lipolytic protein G-D-S-L family
APECO1_RS02550	COG4181	ATPase activity
APECO1_RS02555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
APECO1_RS02580	COG3960	tartronate-semialdehyde synthase activity
APECO1_RS02585	COG3622	Belongs to the hyi family
APECO1_RS02590	COG2084	Dehydrogenase
APECO1_RS02595	COG1953	Uracil, thiamine, allantoin
APECO1_RS02605	COG2233	PERMEase
APECO1_RS02610	COG1929	Belongs to the glycerate kinase type-1 family
APECO1_RS02615	COG3257	ureidoglycine aminohydrolase activity
APECO1_RS02620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APECO1_RS02625	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APECO1_RS02630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APECO1_RS02635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APECO1_RS02645	COG0549	Belongs to the carbamate kinase family
APECO1_RS02650	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APECO1_RS02655	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APECO1_RS02670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APECO1_RS02680	COG1988	membrane-bound metal-dependent
APECO1_RS02685	COG2501	S4 domain
APECO1_RS02705	COG0582	viral genome integration into host DNA
APECO1_RS02710	COG0582	viral genome integration into host DNA
APECO1_RS02715	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APECO1_RS02720	COG0500	methyltransferase
APECO1_RS02725	COG4571	Outer membrane protease
APECO1_RS02735	COG4783	chaperone-mediated protein folding
APECO1_RS02740	COG1215	transferase activity, transferring glycosyl groups
APECO1_RS02745	COG5002	protein histidine kinase activity
APECO1_RS02750	COG0745	RESPONSE REGULATOR receiver
APECO1_RS02755	COG1538	Outer membrane efflux protein
APECO1_RS02760	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO1_RS02765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO1_RS02770	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO1_RS02775	COG1113	amino acid transport
APECO1_RS02780	COG0668	transmembrane transport
APECO1_RS02785	COG0778	Nitroreductase
APECO1_RS02790	COG2315	Protein conserved in bacteria
APECO1_RS02820	COG2977	Belongs to the P-Pant transferase superfamily
APECO1_RS02830	COG4771	TonB-dependent receptor
APECO1_RS02835	COG4771	TonB-dependent receptor
APECO1_RS02840	COG2382	esterase
APECO1_RS02845	COG3251	PFAM MbtH domain protein
APECO1_RS02850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APECO1_RS02850	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
APECO1_RS02855	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APECO1_RS02860	COG1120	ATPase activity
APECO1_RS02865	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO1_RS02870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO1_RS02880	COG4592	Periplasmic binding protein
APECO1_RS02885	COG1169	isochorismate synthase
APECO1_RS02890	COG1021	2,3-dihydroxybenzoate-AMP ligase
APECO1_RS02895	COG1535	isochorismatase
APECO1_RS02895	COG3433	isochorismatase activity
APECO1_RS02900	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS02905	COG2050	protein possibly involved in aromatic compounds catabolism
APECO1_RS02910	COG1966	Carbon starvation protein
APECO1_RS02915	COG2879	small protein
APECO1_RS02920	COG0371	Dehydrogenase
APECO1_RS02925	COG0436	Aminotransferase
APECO1_RS02930	COG1475	DNA binding
APECO1_RS02935	COG3969	phosphoadenosine phosphosulfate
APECO1_RS02940	COG0583	DNA-binding transcription factor activity
APECO1_RS02945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APECO1_RS02950	COG0450	alkyl hydroperoxide reductase
APECO1_RS02955	COG3634	alkyl hydroperoxide reductase activity
APECO1_RS02960	COG0589	response to stress
APECO1_RS02965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APECO1_RS02970	COG3719	Belongs to the RNase T2 family
APECO1_RS02975	COG0471	metal ion transport
APECO1_RS02990	COG3051	citrate lyase alpha subunit
APECO1_RS02995	COG2301	Belongs to the HpcH HpaI aldolase family
APECO1_RS03005	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
APECO1_RS03010	COG3290	protein histidine kinase activity
APECO1_RS03015	COG4565	transcriptional regulatory protein
APECO1_RS03020	COG3069	C4-dicarboxylate transmembrane transporter activity
APECO1_RS03040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APECO1_RS03045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APECO1_RS03070	COG1686	Belongs to the peptidase S11 family
APECO1_RS03080	COG0772	Belongs to the SEDS family
APECO1_RS03085	COG0768	penicillin binding
APECO1_RS03095	COG0799	negative regulation of ribosome biogenesis
APECO1_RS03100	COG0406	alpha-ribazole phosphatase activity
APECO1_RS03110	COG1466	dna polymerase III delta subunit
APECO1_RS03125	COG2888	peptidyl-tyrosine sulfation
APECO1_RS03135	COG1126	abc transporter atp-binding protein
APECO1_RS03140	COG0765	amino acid transport
APECO1_RS03145	COG0765	amino acid transport
APECO1_RS03150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO1_RS03160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APECO1_RS03165	COG4535	Mg2 and Co2 transporter CorC
APECO1_RS03175	COG1702	phosphate starvation-inducible protein PhoH
APECO1_RS03185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APECO1_RS03225	COG0367	asparagine synthase
APECO1_RS03230	COG0647	UMP catabolic process
APECO1_RS03235	COG1846	Transcriptional regulator
APECO1_RS03235	COG1940	carbohydrate kinase activity
APECO1_RS03240	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APECO1_RS03250	COG2190	(PTS) system
APECO1_RS03250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS03250	COG1263	PTS System
APECO1_RS03275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APECO1_RS03280	COG1454	alcohol dehydrogenase
APECO1_RS03285	COG3395	kinase activity
APECO1_RS03290	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APECO1_RS03295	COG1349	DNA-binding transcription factor activity
APECO1_RS03320	COG0735	belongs to the Fur family
APECO1_RS03335	COG0716	FMN binding
APECO1_RS03345	COG0596	Alpha beta hydrolase
APECO1_RS03350	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
APECO1_RS03355	COG0033	Phosphoglucomutase
APECO1_RS03360	COG0531	amino acid
APECO1_RS03365	COG1982	Orn Lys Arg decarboxylase major
APECO1_RS03375	COG0745	RESPONSE REGULATOR receiver
APECO1_RS03380	COG2205	protein histidine kinase activity
APECO1_RS03410	COG3272	Protein of unknown function (DUF1722)
APECO1_RS03415	COG0415	Belongs to the DNA photolyase family
APECO1_RS03425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APECO1_RS03430	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APECO1_RS03435	COG1984	allophanate hydrolase subunit 2
APECO1_RS03450	COG3180	Ammonia monooxygenase
APECO1_RS03455	COG3539	Fimbrial protein
APECO1_RS03460	COG0372	Belongs to the citrate synthase family
APECO1_RS03470	COG2009	succinate dehydrogenase
APECO1_RS03475	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APECO1_RS03480	COG1053	succinate dehydrogenase
APECO1_RS03485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APECO1_RS03495	COG0567	Dehydrogenase, E1 component
APECO1_RS03500	COG0508	dehydrogenase complex catalyzes the overall conversion of
APECO1_RS03510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APECO1_RS03525	COG1271	oxidase subunit
APECO1_RS03530	COG1294	oxidase, subunit
APECO1_RS03535	COG4890	Cyd operon protein YbgT
APECO1_RS03540	COG3790	cyd operon protein YbgE
APECO1_RS03545	COG0824	Thioesterase
APECO1_RS03550	COG0811	peptide transport
APECO1_RS03555	COG0848	biopolymer transport protein
APECO1_RS03560	COG3064	Membrane
APECO1_RS03570	COG2885	chlorophyll binding
APECO1_RS03575	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
APECO1_RS03620	COG3201	nicotinamide mononucleotide transporter
APECO1_RS03625	COG1230	cation diffusion facilitator family transporter
APECO1_RS03640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APECO1_RS03650	COG2017	converts alpha-aldose to the beta-anomer
APECO1_RS03660	COG1085	galactose-1-phosphate uridylyltransferase
APECO1_RS03665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APECO1_RS03670	COG1119	ATPase activity
APECO1_RS03680	COG3585	molybdate ion transport
APECO1_RS03680	COG2005	Transcriptional regulator
APECO1_RS03690	COG0725	ABC transporter, periplasmic molybdate-binding protein
APECO1_RS03695	COG4149	molybdate abc transporter
APECO1_RS03705	COG0561	phosphatase activity
APECO1_RS03715	COG0583	DNA-binding transcription factor activity
APECO1_RS03720	COG2828	Protein conserved in bacteria
APECO1_RS03725	COG0471	metal ion transport
APECO1_RS03730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APECO1_RS03735	COG4677	pectinesterase activity
APECO1_RS03740	COG1881	PFAM PEBP family protein
APECO1_RS03745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APECO1_RS03760	COG2226	methyltransferase
APECO1_RS03765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APECO1_RS03775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
APECO1_RS03790	COG0521	Mo-molybdopterin cofactor biosynthetic process
APECO1_RS03800	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APECO1_RS03805	COG0314	molybdopterin synthase activity
APECO1_RS03810	COG0670	Belongs to the BI1 family
APECO1_RS03815	COG0670	Belongs to the BI1 family
APECO1_RS03820	COG0392	lysyltransferase activity
APECO1_RS03825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APECO1_RS03830	COG3568	Endonuclease Exonuclease Phosphatase
APECO1_RS03840	COG0842	Transport permease protein
APECO1_RS03845	COG0842	Transport permease protein
APECO1_RS03850	COG1131	(ABC) transporter
APECO1_RS03860	COG1309	transcriptional regulator
APECO1_RS03865	COG0513	Belongs to the DEAD box helicase family
APECO1_RS03875	COG1199	ATP-dependent helicase activity
APECO1_RS03880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APECO1_RS03885	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APECO1_RS03895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APECO1_RS03920	COG0668	transmembrane transport
APECO1_RS03925	COG1126	abc transporter atp-binding protein
APECO1_RS03930	COG0765	amino acid transport
APECO1_RS03935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO1_RS03950	COG5006	permease, DMT superfamily
APECO1_RS03955	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APECO1_RS03960	COG2194	sulfuric ester hydrolase activity
APECO1_RS03970	COG1321	iron dependent repressor
APECO1_RS03975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APECO1_RS03980	COG1376	ErfK ybiS ycfS ynhG family protein
APECO1_RS03985	COG0488	(ABC) transporter
APECO1_RS03990	COG0561	phosphatase activity
APECO1_RS03995	COG1882	Formate acetyltransferase
APECO1_RS04000	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APECO1_RS04005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APECO1_RS04010	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APECO1_RS04015	COG0303	'Molybdopterin
APECO1_RS04020	COG1446	asparaginase
APECO1_RS04045	COG2200	EAL domain
APECO1_RS04050	COG2199	diguanylate cyclase activity
APECO1_RS04065	COG2133	pyrroloquinoline quinone binding
APECO1_RS04070	COG0625	glutathione transferase activity
APECO1_RS04075	COG1686	Belongs to the peptidase S11 family
APECO1_RS04080	COG1349	DNA-binding transcription factor activity
APECO1_RS04085	COG0671	phosphoesterase, PA-phosphatase related
APECO1_RS04090	COG2814	Major facilitator Superfamily
APECO1_RS04100	COG0561	phosphatase activity
APECO1_RS04105	COG0738	Major facilitator superfamily
APECO1_RS04110	COG3226	Transcriptional regulator
APECO1_RS04125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APECO1_RS04135	COG0778	Nitroreductase
APECO1_RS04155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APECO1_RS04160	COG3842	ATPase activity
APECO1_RS04165	COG1176	ABC-type spermidine putrescine transport system, permease component I
APECO1_RS04170	COG1177	transmembrane transport
APECO1_RS04185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO1_RS04190	COG4160	amino acid transport
APECO1_RS04195	COG4215	(ABC) transporter
APECO1_RS04200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO1_RS04205	COG1126	abc transporter atp-binding protein
APECO1_RS04220	COG3023	N-Acetylmuramoyl-L-alanine amidase
APECO1_RS04225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APECO1_RS04230	COG0702	epimerase
APECO1_RS04235	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
APECO1_RS04240	COG0028	Belongs to the TPP enzyme family
APECO1_RS04245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APECO1_RS04255	COG2431	L-lysine efflux transmembrane transporter activity
APECO1_RS04270	COG3593	DNA synthesis involved in DNA repair
APECO1_RS04275	COG2990	Protein conserved in bacteria
APECO1_RS04280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO1_RS04290	COG1278	Cold shock
APECO1_RS04300	COG0542	response to heat
APECO1_RS04305	COG1518	maintenance of DNA repeat elements
APECO1_RS04310	COG1203	CRISPR-associated helicase, Cas3
APECO1_RS04350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APECO1_RS04355	COG4988	ABC transporter
APECO1_RS04360	COG0492	ferredoxin-NADP+ reductase activity
APECO1_RS04365	COG1522	sequence-specific DNA binding
APECO1_RS04370	COG1674	ftsk spoiiie
APECO1_RS04370	COG1178	ABC-type Fe3 transport system permease component
APECO1_RS04380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APECO1_RS04390	COG0243	molybdopterin cofactor binding
APECO1_RS04395	COG0437	4 iron, 4 sulfur cluster binding
APECO1_RS04400	COG3302	dmso reductase anchor subunit
APECO1_RS04405	COG1335	isochorismatase
APECO1_RS04415	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APECO1_RS04420	COG4974	Belongs to the 'phage' integrase family
APECO1_RS04470	COG4695	Portal protein
APECO1_RS04555	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO1_RS04580	COG1484	DNA-dependent DNA replication
APECO1_RS04625	COG1882	Formate acetyltransferase
APECO1_RS04630	COG2116	formate transmembrane transporter activity
APECO1_RS04635	COG1944	ATP diphosphatase activity
APECO1_RS04640	COG2323	membrane
APECO1_RS04655	COG0501	Belongs to the peptidase M48B family
APECO1_RS04665	COG0539	negative regulation of cytoplasmic translation
APECO1_RS04690	COG3214	Protein conserved in bacteria
APECO1_RS04705	COG3173	Aminoglycoside phosphotransferase
APECO1_RS04710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APECO1_RS04715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APECO1_RS04725	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
APECO1_RS04735	COG2989	Protein conserved in bacteria
APECO1_RS04740	COG3108	Peptidase M15
APECO1_RS04745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APECO1_RS04750	COG1448	Aminotransferase
APECO1_RS04775	COG0308	aminopeptidase N
APECO1_RS04785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APECO1_RS04795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APECO1_RS04800	COG0431	NADPH-dependent FMN reductase
APECO1_RS04815	COG3217	Mosc domain protein beta barrel domain protein
APECO1_RS04815	COG0633	Ferredoxin
APECO1_RS04825	COG0488	(ABC) transporter
APECO1_RS04830	COG2995	paraquat-inducible protein a
APECO1_RS04835	COG3008	intermembrane lipid transfer
APECO1_RS04835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APECO1_RS04840	COG3009	Protein conserved in bacteria
APECO1_RS04845	COG3130	regulation of translation
APECO1_RS04855	COG1067	ATP-dependent peptidase activity
APECO1_RS04865	COG2885	chlorophyll binding
APECO1_RS04865	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APECO1_RS04880	COG3070	regulator of competence-specific genes
APECO1_RS04885	COG1289	transmembrane transporter activity
APECO1_RS04890	COG3304	Inner membrane component domain
APECO1_RS04895	COG0210	DNA helicase
APECO1_RS04915	COG1832	CoA-binding protein
APECO1_RS04935	COG2920	part of a sulfur-relay system
APECO1_RS04940	COG0670	Belongs to the BI1 family
APECO1_RS04950	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APECO1_RS04955	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APECO1_RS04960	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
APECO1_RS04965	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APECO1_RS04970	COG1999	signal sequence binding
APECO1_RS04975	COG1773	rubredoxin
APECO1_RS04980	COG1271	oxidase subunit
APECO1_RS04985	COG1294	oxidase, subunit
APECO1_RS05000	COG1278	Cold shock
APECO1_RS05005	COG1278	Cold shock
APECO1_RS05020	COG0348	domain, Protein
APECO1_RS05025	COG2198	Histidine kinase
APECO1_RS05025	COG0784	Response regulator, receiver
APECO1_RS05025	COG2205	protein histidine kinase activity
APECO1_RS05030	COG1879	ABC-type sugar transport system periplasmic component
APECO1_RS05035	COG0745	RESPONSE REGULATOR receiver
APECO1_RS05040	COG3005	denitrification pathway
APECO1_RS05045	COG0243	molybdopterin cofactor binding
APECO1_RS05085	COG3729	General stress protein
APECO1_RS05125	COG1309	transcriptional regulator
APECO1_RS05130	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APECO1_RS05130	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APECO1_RS05130	COG0506	proline dehydrogenase activity
APECO1_RS05140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APECO1_RS05160	COG1702	phosphate starvation-inducible protein PhoH
APECO1_RS05165	COG3658	cytochrome
APECO1_RS05170	COG1215	transferase activity, transferring glycosyl groups
APECO1_RS05175	COG1649	PFAM Uncharacterised BCR, COG1649
APECO1_RS05175	COG0726	polysaccharide deacetylase
APECO1_RS05180	COG0457	Tetratricopeptide repeat
APECO1_RS05185	COG3706	GGDEF domain
APECO1_RS05210	COG3381	protein complex oligomerization
APECO1_RS05220	COG1462	curli production assembly transport component CsgG
APECO1_RS05235	COG2197	response regulator
APECO1_RS05265	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APECO1_RS05270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APECO1_RS05295	COG2943	transferase activity, transferring hexosyl groups
APECO1_RS05300	COG5645	(Lipo)protein
APECO1_RS05320	COG1560	Kdo2-lipid A biosynthetic process
APECO1_RS05330	COG2353	YceI-like domain
APECO1_RS05335	COG3038	cytochrome b561
APECO1_RS05370	COG2999	glutathione oxidoreductase activity
APECO1_RS05380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APECO1_RS05390	COG0673	inositol 2-dehydrogenase activity
APECO1_RS05395	COG0728	peptidoglycan biosynthetic process
APECO1_RS05400	COG3418	PFAM FlgN family protein
APECO1_RS05405	COG2747	anti-sigma28 factor FlgM
APECO1_RS05410	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
APECO1_RS05415	COG1815	bacterial-type flagellum-dependent cell motility
APECO1_RS05420	COG1558	bacterial-type flagellum-dependent cell motility
APECO1_RS05425	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
APECO1_RS05430	COG1749	Flagellar hook protein flgE
APECO1_RS05435	COG4787	bacterial-type flagellum-dependent cell motility
APECO1_RS05440	COG4786	Flagellar basal body rod
APECO1_RS05455	COG3951	Flagellar rod assembly protein muramidase FlgJ
APECO1_RS05455	COG1705	Flagellar rod assembly protein muramidase FlgJ
APECO1_RS05460	COG1256	bacterial-type flagellum assembly
APECO1_RS05465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APECO1_RS05470	COG1530	ribonuclease E activity
APECO1_RS05480	COG0564	pseudouridine synthase activity
APECO1_RS05485	COG0424	maF-like protein
APECO1_RS05490	COG1399	metal-binding, possibly nucleic acid-binding protein
APECO1_RS05510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APECO1_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS05525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APECO1_RS05530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APECO1_RS05535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APECO1_RS05545	COG0470	DNA polymerase III
APECO1_RS05550	COG0084	hydrolase, TatD family'
APECO1_RS05555	COG1263	PTS System
APECO1_RS05555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS05560	COG4773	Receptor
APECO1_RS05565	COG0537	adenosine 5'-monophosphoramidase activity
APECO1_RS05570	COG5633	Lipoprotein
APECO1_RS05575	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
APECO1_RS05595	COG1252	NADH dehydrogenase
APECO1_RS05600	COG3134	Outer membrane lipoprotein
APECO1_RS05605	COG1309	transcriptional regulator
APECO1_RS05615	COG1376	ErfK ybiS ycfS ynhG family protein
APECO1_RS05615	COG1388	LysM domain
APECO1_RS05620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APECO1_RS05625	COG4763	Acyl-transferase
APECO1_RS05630	COG4591	ABC-type transport system involved in lipoprotein release permease component
APECO1_RS05640	COG4591	ABC-type transport system involved in lipoprotein release permease component
APECO1_RS05650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APECO1_RS05655	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APECO1_RS05665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APECO1_RS05670	COG1177	transmembrane transport
APECO1_RS05695	COG2850	peptidyl-arginine hydroxylation
APECO1_RS05700	COG2205	protein histidine kinase activity
APECO1_RS05710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APECO1_RS05730	COG1187	pseudouridine synthase activity
APECO1_RS05735	COG0538	isocitrate dehydrogenase activity
APECO1_RS05740	COG0582	viral genome integration into host DNA
APECO1_RS05930	COG3772	lysozyme
APECO1_RS05965	COG4220	transposase activity
APECO1_RS06035	COG1196	nuclear chromosome segregation
APECO1_RS06065	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO1_RS06080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APECO1_RS06085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APECO1_RS06090	COG1121	(ABC) transporter
APECO1_RS06120	COG5562	phage envelope protein
APECO1_RS06125	COG0789	Transcriptional regulator
APECO1_RS06130	COG2200	EAL domain
APECO1_RS06155	COG2200	EAL domain
APECO1_RS06210	COG2894	cell division
APECO1_RS06235	COG0179	Fumarylacetoacetate (FAA) hydrolase
APECO1_RS06250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APECO1_RS06255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APECO1_RS06275	COG2719	SpoVR family
APECO1_RS06285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APECO1_RS06295	COG1619	proteins homologs of microcin C7 resistance protein MccF
APECO1_RS06305	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
APECO1_RS06320	COG0157	Belongs to the NadC ModD family
APECO1_RS06325	COG0500	methyltransferase
APECO1_RS06330	COG1120	ATPase activity
APECO1_RS06335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO1_RS06340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APECO1_RS06350	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
APECO1_RS06350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS06350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APECO1_RS06355	COG1461	Dihydroxyacetone kinase
APECO1_RS06360	COG2376	Dihydroxyacetone kinase
APECO1_RS06365	COG3284	Transcriptional regulator
APECO1_RS06375	COG0012	GTP binding
APECO1_RS06390	COG0659	secondary active sulfate transmembrane transporter activity
APECO1_RS06395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APECO1_RS06420	COG2890	protein-(glutamine-N5) methyltransferase activity
APECO1_RS06425	COG3094	Invasion gene expression up-regulator, SirB
APECO1_RS06430	COG2912	Transglutaminase-like superfamily
APECO1_RS06445	COG0387	Pfam Sodium calcium exchanger
APECO1_RS06450	COG4572	Cation transport regulator
APECO1_RS06455	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
APECO1_RS06460	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APECO1_RS06465	COG4932	domain protein
APECO1_RS06470	COG2197	response regulator
APECO1_RS06475	COG3850	Histidine kinase
APECO1_RS06485	COG2223	nitrite transmembrane transporter activity
APECO1_RS06490	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APECO1_RS06495	COG1140	nitrate reductase beta subunit
APECO1_RS06500	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APECO1_RS06505	COG2181	nitrate reductase activity
APECO1_RS06525	COG0788	formyltetrahydrofolate deformylase activity
APECO1_RS06535	COG1752	Esterase of the alpha-beta hydrolase superfamily
APECO1_RS06540	COG0745	RESPONSE REGULATOR receiver
APECO1_RS06545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APECO1_RS06555	COG1435	thymidine kinase activity
APECO1_RS06560	COG3385	transposase activity
APECO1_RS06565	COG3385	transposase activity
APECO1_RS06570	COG1454	alcohol dehydrogenase
APECO1_RS06570	COG1012	belongs to the aldehyde dehydrogenase family
APECO1_RS06575	COG2095	MarC family integral membrane protein
APECO1_RS06580	COG4166	transmembrane transport
APECO1_RS06585	COG0601	transmembrane transport
APECO1_RS06590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APECO1_RS06595	COG0444	Belongs to the ABC transporter superfamily
APECO1_RS06600	COG4608	Belongs to the ABC transporter superfamily
APECO1_RS06620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APECO1_RS06625	COG2350	Protein conserved in bacteria
APECO1_RS06635	COG1607	acyl-coa hydrolase
APECO1_RS06650	COG3047	cAMP biosynthetic process
APECO1_RS06655	COG0582	viral genome integration into host DNA
APECO1_RS06665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APECO1_RS06740	COG1403	HNH endonuclease
APECO1_RS06745	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APECO1_RS06750	COG0484	heat shock protein binding
APECO1_RS06810	COG5562	phage envelope protein
APECO1_RS06825	COG4220	transposase activity
APECO1_RS06935	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO1_RS06940	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APECO1_RS06945	COG0500	methyltransferase
APECO1_RS06960	COG3685	Protein conserved in bacteria
APECO1_RS06965	COG3685	Protein conserved in bacteria
APECO1_RS06970	COG3729	General stress protein
APECO1_RS06985	COG0135	phosphoribosylanthranilate isomerase activity
APECO1_RS06985	COG0134	indole-3-glycerol-phosphate synthase activity
APECO1_RS06990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APECO1_RS06990	COG0512	Glutamine amidotransferase of anthranilate synthase
APECO1_RS06995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APECO1_RS07000	COG0613	PHP domain protein
APECO1_RS07005	COG0009	L-threonylcarbamoyladenylate synthase
APECO1_RS07010	COG4907	membrane protein (DUF2207)
APECO1_RS07015	COG1187	pseudouridine synthase activity
APECO1_RS07020	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
APECO1_RS07025	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS07035	COG0616	signal peptide processing
APECO1_RS07050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APECO1_RS07055	COG0583	DNA-binding transcription factor activity
APECO1_RS07080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APECO1_RS07090	COG0671	phosphoesterase, PA-phosphatase related
APECO1_RS07095	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
APECO1_RS07100	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APECO1_RS07110	COG0023	Translation Initiation Factor
APECO1_RS07120	COG1349	DNA-binding transcription factor activity
APECO1_RS07130	COG5001	Diguanylate cyclase
APECO1_RS07145	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APECO1_RS07145	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APECO1_RS07150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APECO1_RS07160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO1_RS07165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO1_RS07175	COG2814	Major facilitator Superfamily
APECO1_RS07180	COG4172	Belongs to the ABC transporter superfamily
APECO1_RS07185	COG4172	Belongs to the ABC transporter superfamily
APECO1_RS07190	COG4171	peptide transport system, permease
APECO1_RS07195	COG4168	peptide transport system, permease
APECO1_RS07200	COG4166	transmembrane transport
APECO1_RS07220	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
APECO1_RS07225	COG1842	Phage shock protein A
APECO1_RS07235	COG1983	PspC domain protein
APECO1_RS07245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APECO1_RS07250	COG0366	Alpha amylase catalytic
APECO1_RS07255	COG1653	transport
APECO1_RS07260	COG1175	transmembrane transport
APECO1_RS07265	COG0395	ABC-type sugar transport system, permease component
APECO1_RS07270	COG1063	alcohol dehydrogenase
APECO1_RS07275	COG1082	Xylose isomerase domain protein TIM barrel
APECO1_RS07280	COG0673	inositol 2-dehydrogenase activity
APECO1_RS07285	COG1554	hydrolase, family 65, central catalytic
APECO1_RS07290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APECO1_RS07305	COG1609	Transcriptional regulator
APECO1_RS07310	COG3106	COG3106 Predicted ATPase
APECO1_RS07320	COG3283	Transcriptional regulator of aromatic amino acids metabolism
APECO1_RS07325	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APECO1_RS07330	COG4948	Mandelate Racemase Muconate Lactonizing
APECO1_RS07335	COG2866	Carboxypeptidase
APECO1_RS07340	COG0702	epimerase
APECO1_RS07345	COG1073	alpha beta
APECO1_RS07350	COG0583	DNA-binding transcription factor activity
APECO1_RS07360	COG4166	transmembrane transport
APECO1_RS07365	COG0668	transmembrane transport
APECO1_RS07370	COG3182	Iron-regulated membrane protein
APECO1_RS07375	COG0589	response to stress
APECO1_RS07380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APECO1_RS07385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APECO1_RS07390	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
APECO1_RS07400	COG2207	Transcriptional regulator
APECO1_RS07415	COG2840	Smr protein MutS2
APECO1_RS07420	COG3706	GGDEF domain
APECO1_RS07435	COG0513	Belongs to the DEAD box helicase family
APECO1_RS07445	COG0582	viral genome integration into host DNA
APECO1_RS07465	COG3723	Recombinational DNA repair protein, rece pathway
APECO1_RS07470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APECO1_RS07510	COG3756	Protein conserved in bacteria
APECO1_RS07515	COG1484	DNA-dependent DNA replication
APECO1_RS07520	COG1846	Transcriptional regulator
APECO1_RS07530	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APECO1_RS07585	COG3772	lysozyme
APECO1_RS07595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APECO1_RS07600	COG1475	DNA binding
APECO1_RS07685	COG1196	nuclear chromosome segregation
APECO1_RS07720	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO1_RS07760	COG4571	Outer membrane protease
APECO1_RS07770	COG0582	viral genome integration into host DNA
APECO1_RS07780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APECO1_RS07790	COG0589	response to stress
APECO1_RS07795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APECO1_RS07800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APECO1_RS07800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APECO1_RS07800	COG1013	pyruvate-flavodoxin oxidoreductase activity
APECO1_RS07800	COG0674	pyruvate-flavodoxin oxidoreductase activity
APECO1_RS07805	COG3042	response to heat
APECO1_RS07810	COG3187	Heat shock protein
APECO1_RS07815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APECO1_RS07820	COG2911	Protein conserved in bacteria
APECO1_RS07830	COG3784	Protein of unknown function (DUF1318)
APECO1_RS07845	COG0667	Aldo Keto reductase
APECO1_RS07850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APECO1_RS07855	COG4589	Belongs to the CDS family
APECO1_RS07860	COG2267	carboxylic ester hydrolase activity
APECO1_RS07865	COG0671	phosphoesterase, PA-phosphatase related
APECO1_RS07865	COG2453	phosphatase
APECO1_RS07875	COG1643	Atp-dependent helicase
APECO1_RS07880	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APECO1_RS07885	COG1012	belongs to the aldehyde dehydrogenase family
APECO1_RS07890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APECO1_RS07895	COG3038	cytochrome b561
APECO1_RS07910	COG0840	transmembrane signaling receptor activity
APECO1_RS07915	COG0583	DNA-binding transcription factor activity
APECO1_RS07920	COG5383	Protein conserved in bacteria
APECO1_RS07935	COG2841	Protein conserved in bacteria
APECO1_RS07940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APECO1_RS07945	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APECO1_RS07950	COG1275	C4-dicarboxylate transporter malic acid transport protein
APECO1_RS07955	COG0500	methyltransferase
APECO1_RS07965	COG3135	benzoate transporter
APECO1_RS07970	COG1396	sequence-specific DNA binding
APECO1_RS07975	COG0826	peptidase U32
APECO1_RS07985	COG1598	PFAM Uncharacterised protein family UPF0150
APECO1_RS07990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APECO1_RS07995	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APECO1_RS08000	COG3842	ATPase activity
APECO1_RS08005	COG1176	ABC-type spermidine putrescine transport system, permease component I
APECO1_RS08010	COG1177	transmembrane transport
APECO1_RS08035	COG3238	Protein conserved in bacteria
APECO1_RS08040	COG1247	-acetyltransferase
APECO1_RS08045	COG1802	Transcriptional regulator
APECO1_RS08050	COG4772	TonB-dependent receptor
APECO1_RS08060	COG1113	amino acid transport
APECO1_RS08065	COG0625	glutathione transferase activity
APECO1_RS08070	COG0625	glutathione transferase activity
APECO1_RS08080	COG3501	Rhs element vgr protein
APECO1_RS08095	COG5433	transposase activity
APECO1_RS08110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APECO1_RS08115	COG2162	N-hydroxyarylamine O-acetyltransferase activity
APECO1_RS08120	COG0384	phenazine biosynthesis protein PhzF
APECO1_RS08125	COG2181	nitrate reductase activity
APECO1_RS08130	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APECO1_RS08135	COG1140	nitrate reductase beta subunit
APECO1_RS08140	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APECO1_RS08145	COG2223	nitrite transmembrane transporter activity
APECO1_RS08150	COG0697	spore germination
APECO1_RS08155	COG3383	formate dehydrogenase (NAD+) activity
APECO1_RS08155	COG0243	molybdopterin cofactor binding
APECO1_RS08160	COG3383	formate dehydrogenase (NAD+) activity
APECO1_RS08160	COG0243	molybdopterin cofactor binding
APECO1_RS08165	COG0437	4 iron, 4 sulfur cluster binding
APECO1_RS08170	COG2864	formate dehydrogenase
APECO1_RS08175	COG3093	addiction module antidote protein HigA
APECO1_RS08185	COG1064	alcohol dehydrogenase
APECO1_RS08205	COG1764	response to oxidative stress
APECO1_RS08210	COG2199	diguanylate cyclase activity
APECO1_RS08210	COG2200	EAL domain
APECO1_RS08210	COG2202	Pas domain
APECO1_RS08215	COG3706	GGDEF domain
APECO1_RS08215	COG3706	GGDEF domain
APECO1_RS08220	COG1649	PFAM Uncharacterised BCR, COG1649
APECO1_RS08225	COG0531	amino acid
APECO1_RS08230	COG0076	glutamate decarboxylase activity
APECO1_RS08240	COG0612	Peptidase, M16
APECO1_RS08245	COG4771	TonB-dependent receptor
APECO1_RS08250	COG4178	(ABC) transporter
APECO1_RS08255	COG0641	radical SAM
APECO1_RS08260	COG3119	arylsulfatase activity
APECO1_RS08265	COG2207	Transcriptional regulator
APECO1_RS08275	COG0243	molybdopterin cofactor binding
APECO1_RS08280	COG3539	Fimbrial protein
APECO1_RS08285	COG3539	Fimbrial protein
APECO1_RS08290	COG3539	Fimbrial protein
APECO1_RS08295	COG3188	usher protein
APECO1_RS08305	COG3539	Fimbrial protein
APECO1_RS08315	COG0702	epimerase
APECO1_RS08325	COG3550	peptidyl-serine autophosphorylation
APECO1_RS08330	COG1396	sequence-specific DNA binding
APECO1_RS08340	COG3781	membrane
APECO1_RS08355	COG2199	diguanylate cyclase activity
APECO1_RS08365	COG2066	Belongs to the glutaminase family
APECO1_RS08370	COG1012	belongs to the aldehyde dehydrogenase family
APECO1_RS08375	COG0583	DNA-binding transcription factor activity
APECO1_RS08390	COG1846	Transcriptional regulator
APECO1_RS08395	COG4977	sequence-specific DNA binding
APECO1_RS08405	COG2723	6-phospho-beta-galactosidase activity
APECO1_RS08415	COG1447	Phosphotransferase system cellobiose-specific component IIA
APECO1_RS08420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APECO1_RS08430	COG2188	Transcriptional regulator
APECO1_RS08435	COG0697	spore germination
APECO1_RS08440	COG2814	Major facilitator Superfamily
APECO1_RS08450	COG3706	GGDEF domain
APECO1_RS08455	COG3111	PFAM Bacterial OB fold (BOF) protein
APECO1_RS08460	COG0339	signal peptide processing
APECO1_RS08465	COG4221	oxidoreductase activity
APECO1_RS08470	COG1802	Transcriptional regulator
APECO1_RS08480	COG0246	Mannitol dehydrogenase
APECO1_RS08485	COG0477	Major facilitator Superfamily
APECO1_RS08490	COG1063	alcohol dehydrogenase
APECO1_RS08495	COG4948	Mandelate Racemase Muconate Lactonizing
APECO1_RS08510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APECO1_RS08525	COG0243	molybdopterin cofactor binding
APECO1_RS08530	COG0243	molybdopterin cofactor binding
APECO1_RS08535	COG0437	4 iron, 4 sulfur cluster binding
APECO1_RS08540	COG3302	dmso reductase anchor subunit
APECO1_RS08545	COG3381	protein complex oligomerization
APECO1_RS08555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APECO1_RS08560	COG1940	carbohydrate kinase activity
APECO1_RS08565	COG0583	DNA-binding transcription factor activity
APECO1_RS08570	COG2814	Major facilitator Superfamily
APECO1_RS08585	COG3591	Belongs to the peptidase S1B family
APECO1_RS08600	COG0628	permease
APECO1_RS08605	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APECO1_RS08610	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APECO1_RS08620	COG0531	amino acid
APECO1_RS08630	COG3136	membrane protein required for alginate biosynthesis
APECO1_RS08635	COG0745	RESPONSE REGULATOR receiver
APECO1_RS08640	COG2205	protein histidine kinase activity
APECO1_RS08650	COG0114	fumarate hydratase activity
APECO1_RS08655	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO1_RS08655	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO1_RS08660	COG1482	cell wall glycoprotein biosynthetic process
APECO1_RS08665	COG5339	Protein conserved in bacteria
APECO1_RS08680	COG3250	beta-galactosidase activity
APECO1_RS08685	COG1309	transcriptional regulator
APECO1_RS08690	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS08695	COG1609	Transcriptional regulator
APECO1_RS08700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS08700	COG1263	PTS System
APECO1_RS08705	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APECO1_RS08715	COG0673	inositol 2-dehydrogenase activity
APECO1_RS08755	COG4659	FMN binding
APECO1_RS08765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APECO1_RS08775	COG3104	oligopeptide transport
APECO1_RS08780	COG0625	glutathione transferase activity
APECO1_RS08800	COG3895	Periplasmic Protein
APECO1_RS08810	COG3133	Outer membrane lipoprotein
APECO1_RS08830	COG1289	transmembrane transporter activity
APECO1_RS08835	COG2032	superoxide dismutase activity
APECO1_RS08840	COG4989	oxidoreductase activity
APECO1_RS08845	COG3313	Fe-S protein
APECO1_RS08850	COG1309	transcriptional regulator
APECO1_RS08855	COG1902	pentaerythritol trinitrate reductase activity
APECO1_RS08860	COG0346	lactoylglutathione lyase activity
APECO1_RS08870	COG1201	RNA secondary structure unwinding
APECO1_RS08875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APECO1_RS08880	COG0791	NLP P60 protein
APECO1_RS08885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APECO1_RS08890	COG2814	Major facilitator Superfamily
APECO1_RS08905	COG0583	DNA-binding transcription factor activity
APECO1_RS08910	COG2814	Major facilitator Superfamily
APECO1_RS08915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APECO1_RS08920	COG0307	riboflavin synthase, alpha
APECO1_RS08930	COG3468	outer membrane autotransporter barrel domain protein
APECO1_RS08950	COG4529	Protein conserved in bacteria
APECO1_RS08960	COG4529	Protein conserved in bacteria
APECO1_RS08970	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
APECO1_RS08975	COG0437	4 iron, 4 sulfur cluster binding
APECO1_RS08985	COG2414	aldehyde ferredoxin oxidoreductase
APECO1_RS08990	COG0437	4 iron, 4 sulfur cluster binding
APECO1_RS09000	COG0469	pyruvate kinase activity
APECO1_RS09005	COG4238	major outer membrane lipoprotein
APECO1_RS09010	COG1376	ErfK ybiS ycfS ynhG family protein
APECO1_RS09025	COG0719	Fe-S assembly protein
APECO1_RS09030	COG0396	ATPase activity
APECO1_RS09035	COG0719	Fe-S assembly protein
APECO1_RS09040	COG0316	Belongs to the HesB IscA family
APECO1_RS09050	COG2050	protein possibly involved in aromatic compounds catabolism
APECO1_RS09055	COG0247	lactate metabolic process
APECO1_RS09055	COG0277	FAD linked oxidase domain protein
APECO1_RS09060	COG0628	permease
APECO1_RS09070	COG0738	Major facilitator superfamily
APECO1_RS09075	COG2271	Major facilitator Superfamily
APECO1_RS09090	COG4670	ketone body catabolic process
APECO1_RS09095	COG1960	acyl-CoA dehydrogenase activity
APECO1_RS09100	COG1917	Cupin 2, conserved barrel domain protein
APECO1_RS09100	COG2207	Transcriptional regulator
APECO1_RS09110	COG2086	electron transfer activity
APECO1_RS09115	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APECO1_RS09120	COG0644	oxidoreductase
APECO1_RS09125	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
APECO1_RS09130	COG0318	PFAM AMP-dependent synthetase and ligase
APECO1_RS09135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APECO1_RS09135	COG0574	Belongs to the PEP-utilizing enzyme family
APECO1_RS09150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APECO1_RS09155	COG4256	Hemin uptake protein
APECO1_RS09165	COG2200	EAL domain
APECO1_RS09170	COG0791	NLP P60 protein
APECO1_RS09180	COG0386	Belongs to the glutathione peroxidase family
APECO1_RS09240	COG3137	Salt-induced outer membrane protein
APECO1_RS09245	COG1105	Belongs to the carbohydrate kinase PfkB family
APECO1_RS09255	COG3001	Fructosamine kinase
APECO1_RS09265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APECO1_RS09270	COG1988	membrane-bound metal-dependent
APECO1_RS09275	COG1823	symporter activity
APECO1_RS09285	COG0753	catalase activity
APECO1_RS09295	COG1486	melibiose metabolic process
APECO1_RS09300	COG1917	Cupin 2, conserved barrel domain protein
APECO1_RS09300	COG2169	Transcriptional regulator
APECO1_RS09305	COG1447	Phosphotransferase system cellobiose-specific component IIA
APECO1_RS09310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APECO1_RS09315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APECO1_RS09320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APECO1_RS09335	COG0322	excinuclease ABC activity
APECO1_RS09345	COG3678	ATP-independent chaperone mediated protein folding
APECO1_RS09375	COG0708	Exodeoxyribonuclease III
APECO1_RS09380	COG0398	Pfam SNARE associated Golgi protein
APECO1_RS09390	COG0398	Pfam SNARE associated Golgi protein
APECO1_RS09395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APECO1_RS09400	COG4134	Bacterial extracellular solute-binding protein
APECO1_RS09405	COG4135	transport system, permease component
APECO1_RS09410	COG4136	ATPase activity
APECO1_RS09415	COG2897	thiosulfate sulfurtransferase activity
APECO1_RS09420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APECO1_RS09425	COG0494	nUDIX hydrolase
APECO1_RS09435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APECO1_RS09440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APECO1_RS09455	COG0778	Nitroreductase
APECO1_RS09465	COG0616	signal peptide processing
APECO1_RS09470	COG0252	asparaginase activity
APECO1_RS09475	COG1335	isochorismatase
APECO1_RS09480	COG2814	Major facilitator Superfamily
APECO1_RS09485	COG1349	DNA-binding transcription factor activity
APECO1_RS09490	COG0667	Aldo Keto reductase
APECO1_RS09500	COG0191	fructose-bisphosphate aldolase activity
APECO1_RS09505	COG1063	alcohol dehydrogenase
APECO1_RS09510	COG2271	Major facilitator Superfamily
APECO1_RS09515	COG1063	alcohol dehydrogenase
APECO1_RS09520	COG3139	Protein of unknown function (DUF1315)
APECO1_RS09530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APECO1_RS09535	COG0676	glucose-6-phosphate 1-epimerase activity
APECO1_RS09540	COG0656	L-ascorbic acid biosynthetic process
APECO1_RS09545	COG3713	MltA-interacting MipA family protein
APECO1_RS09550	COG2766	serine protein kinase
APECO1_RS09560	COG2199	diguanylate cyclase activity
APECO1_RS09565	COG2199	diguanylate cyclase activity
APECO1_RS09570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APECO1_RS09585	COG2207	Transcriptional regulator
APECO1_RS09590	COG2807	transmembrane transport
APECO1_RS09595	COG3189	MarR family transcriptional regulator
APECO1_RS09600	COG3042	response to heat
APECO1_RS09605	COG2203	Gaf domain
APECO1_RS09605	COG2199	diguanylate cyclase activity
APECO1_RS09615	COG2261	transglycosylase associated protein
APECO1_RS09625	COG3615	Tellurite resistance protein tehB
APECO1_RS09635	COG0583	DNA-binding transcription factor activity
APECO1_RS09640	COG0473	3-isopropylmalate dehydrogenase activity
APECO1_RS09645	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APECO1_RS09650	COG0318	PFAM AMP-dependent synthetase and ligase
APECO1_RS09655	COG3065	identical protein binding
APECO1_RS09660	COG1214	PFAM Peptidase M22, glycoprotease
APECO1_RS09665	COG1199	ATP-dependent helicase activity
APECO1_RS09670	COG0251	oxidation-reduction process
APECO1_RS09690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APECO1_RS09700	COG1760	l-serine dehydratase
APECO1_RS09705	COG2200	EAL domain
APECO1_RS09710	COG1253	flavin adenine dinucleotide binding
APECO1_RS09720	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS09720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS09725	COG3715	PTS system
APECO1_RS09730	COG3716	PTS system mannose fructose sorbose family IID component
APECO1_RS09750	COG2226	methyltransferase
APECO1_RS09785	COG1414	Transcriptional regulator
APECO1_RS09790	COG2814	Major facilitator Superfamily
APECO1_RS09800	COG0793	Belongs to the peptidase S41A family
APECO1_RS09810	COG1956	GAF domain-containing protein
APECO1_RS09815	COG2995	paraquat-inducible protein a
APECO1_RS09820	COG3008	intermembrane lipid transfer
APECO1_RS09840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APECO1_RS09855	COG1276	copper resistance
APECO1_RS09860	COG2372	response to copper ion
APECO1_RS09875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APECO1_RS09880	COG1770	oligopeptidase
APECO1_RS09885	COG2979	Protein of unknown function (DUF533)
APECO1_RS09900	COG3141	response to X-ray
APECO1_RS09910	COG0800	Aldolase
APECO1_RS09915	COG0129	dihydroxy-acid dehydratase activity
APECO1_RS09920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APECO1_RS09930	COG1737	Transcriptional regulator
APECO1_RS09935	COG0469	pyruvate kinase activity
APECO1_RS09940	COG1560	Kdo2-lipid A biosynthetic process
APECO1_RS09945	COG0739	heme binding
APECO1_RS09950	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
APECO1_RS09960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APECO1_RS09985	COG0217	transcriptional regulatory protein
APECO1_RS09990	COG0494	nUDIX hydrolase
APECO1_RS10000	COG1335	isochorismatase
APECO1_RS10005	COG1801	Protein of unknown function DUF72
APECO1_RS10010	COG3788	relative of glutathione S-transferase, MAPEG superfamily
APECO1_RS10030	COG3005	denitrification pathway
APECO1_RS10040	COG3102	Protein conserved in bacteria
APECO1_RS10055	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APECO1_RS10060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APECO1_RS10065	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
APECO1_RS10070	COG0745	RESPONSE REGULATOR receiver
APECO1_RS10080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APECO1_RS10090	COG0840	transmembrane signaling receptor activity
APECO1_RS10095	COG0835	chemotaxis
APECO1_RS10100	COG0643	Histidine kinase
APECO1_RS10100	COG2198	Histidine kinase
APECO1_RS10105	COG1360	Flagellar Motor Protein
APECO1_RS10110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APECO1_RS10125	COG0589	response to stress
APECO1_RS10135	COG1877	trehalose-phosphatase activity
APECO1_RS10140	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS10150	COG1879	ABC-type sugar transport system periplasmic component
APECO1_RS10155	COG1528	Iron-storage protein
APECO1_RS10175	COG1528	Iron-storage protein
APECO1_RS10185	COG0814	amino acid
APECO1_RS10190	COG3318	Belongs to the UPF0149 family
APECO1_RS10190	COG3012	SEC-C Motif Domain Protein
APECO1_RS10220	COG2197	response regulator
APECO1_RS10235	COG2197	response regulator
APECO1_RS10240	COG1126	abc transporter atp-binding protein
APECO1_RS10245	COG0765	amino acid transport
APECO1_RS10255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO1_RS10265	COG1191	sigma factor activity
APECO1_RS10275	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APECO1_RS10280	COG1516	flagellar protein fliS
APECO1_RS10290	COG0366	Alpha amylase catalytic
APECO1_RS10300	COG2391	methyltransferase activity
APECO1_RS10305	COG0425	Belongs to the sulfur carrier protein TusA family
APECO1_RS10310	COG2135	peptidase activity
APECO1_RS10320	COG2207	Transcriptional regulator
APECO1_RS10325	COG1881	PFAM PEBP family protein
APECO1_RS10330	COG2076	Multidrug Resistance protein
APECO1_RS10355	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APECO1_RS10360	COG1317	bacterial-type flagellum organization
APECO1_RS10365	COG1157	protein secretion by the type III secretion system
APECO1_RS10370	COG2882	bacterial-type flagellum organization
APECO1_RS10375	COG3144	bacterial-type flagellum assembly
APECO1_RS10380	COG1580	Controls the rotational direction of flagella during chemotaxis
APECO1_RS10385	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APECO1_RS10390	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APECO1_RS10395	COG3190	flagellar
APECO1_RS10400	COG1338	Plays a role in the flagellum-specific transport system
APECO1_RS10405	COG1987	bacterial-type flagellum assembly
APECO1_RS10410	COG1684	flagellar biosynthetic protein fliR
APECO1_RS10415	COG2197	response regulator
APECO1_RS10440	COG2354	Protein conserved in bacteria
APECO1_RS10445	COG0697	spore germination
APECO1_RS10450	COG3727	T/G mismatch-specific endonuclease activity
APECO1_RS10455	COG0270	DNA (cytosine-5-)-methyltransferase activity
APECO1_RS10460	COG1418	mRNA catabolic process
APECO1_RS10475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APECO1_RS10490	COG2205	protein histidine kinase activity
APECO1_RS10495	COG0745	RESPONSE REGULATOR receiver
APECO1_RS10500	COG2351	hydroxyisourate hydrolase activity
APECO1_RS10515	COG3443	Belongs to the bacterial solute-binding protein 9 family
APECO1_RS10525	COG2267	carboxylic ester hydrolase activity
APECO1_RS10540	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO1_RS10650	COG3772	lysozyme
APECO1_RS10695	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APECO1_RS10700	COG1403	HNH endonuclease
APECO1_RS10790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APECO1_RS10825	COG1169	isochorismate synthase
APECO1_RS10830	COG2814	Major facilitator Superfamily
APECO1_RS10835	COG1132	(ABC) transporter
APECO1_RS10850	COG2226	methyltransferase
APECO1_RS10850	COG3433	isochorismatase activity
APECO1_RS10850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APECO1_RS10870	COG1021	2,3-dihydroxybenzoate-AMP ligase
APECO1_RS10875	COG4771	TonB-dependent receptor
APECO1_RS10880	COG1388	LysM domain
APECO1_RS10880	COG2373	Large extracellular alpha-helical protein
APECO1_RS10880	COG4932	domain protein
APECO1_RS10885	COG1388	LysM domain
APECO1_RS10885	COG1470	cell adhesion involved in biofilm formation
APECO1_RS10890	COG1470	cell adhesion involved in biofilm formation
APECO1_RS10890	COG1388	LysM domain
APECO1_RS10900	COG0477	Major facilitator Superfamily
APECO1_RS10905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APECO1_RS10910	COG0217	transcriptional regulatory protein
APECO1_RS10930	COG0583	DNA-binding transcription factor activity
APECO1_RS10935	COG0583	DNA-binding transcription factor activity
APECO1_RS10945	COG1376	ErfK ybiS ycfS ynhG family protein
APECO1_RS10960	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
APECO1_RS10995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO1_RS11010	COG1735	metal-dependent hydrolase with the TIM-barrel fold
APECO1_RS11015	COG0405	Gamma-glutamyltransferase
APECO1_RS11070	COG2801	Transposase and inactivated derivatives
APECO1_RS11075	COG2963	transposase activity
APECO1_RS11135	COG2003	Belongs to the UPF0758 family
APECO1_RS11165	COG4917	ethanolamine utilization protein
APECO1_RS11175	COG1289	transmembrane transporter activity
APECO1_RS11185	COG1686	Belongs to the peptidase S11 family
APECO1_RS11190	COG2925	Exonuclease
APECO1_RS11195	COG0425	Belongs to the sulfur carrier protein TusA family
APECO1_RS11200	COG2391	methyltransferase activity
APECO1_RS11205	COG0531	amino acid
APECO1_RS11210	COG0583	DNA-binding transcription factor activity
APECO1_RS11215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APECO1_RS11220	COG4115	mRNA cleavage
APECO1_RS11225	COG2161	toxin-antitoxin pair type II binding
APECO1_RS11235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APECO1_RS11245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APECO1_RS11245	COG0131	Imidazoleglycerol-phosphate dehydratase
APECO1_RS11250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APECO1_RS11265	COG0140	phosphoribosyl-ATP diphosphatase activity
APECO1_RS11265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APECO1_RS11270	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APECO1_RS11275	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APECO1_RS11280	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APECO1_RS11290	COG0463	Glycosyl transferase, family 2
APECO1_RS11320	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APECO1_RS11325	COG1091	dTDP-4-dehydrorhamnose reductase activity
APECO1_RS11330	COG1088	dTDP-glucose 4,6-dehydratase activity
APECO1_RS11335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APECO1_RS11345	COG0438	transferase activity, transferring glycosyl groups
APECO1_RS11350	COG2327	Polysaccharide pyruvyl transferase
APECO1_RS11355	COG2244	polysaccharide biosynthetic process
APECO1_RS11360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APECO1_RS11365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APECO1_RS11370	COG0662	Cupin 2, conserved barrel domain protein
APECO1_RS11370	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APECO1_RS11375	COG0297	glycogen (starch) synthase activity
APECO1_RS11380	COG1051	belongs to the nudix hydrolase family
APECO1_RS11385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APECO1_RS11390	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
APECO1_RS11395	COG0110	maltose O-acetyltransferase activity
APECO1_RS11400	COG1216	Glycosyl transferase, family 2
APECO1_RS11410	COG0438	transferase activity, transferring glycosyl groups
APECO1_RS11415	COG1045	serine acetyltransferase
APECO1_RS11420	COG0463	Glycosyl transferase, family 2
APECO1_RS11425	COG3206	protein involved in exopolysaccharide biosynthesis
APECO1_RS11425	COG0489	protein tyrosine kinase activity
APECO1_RS11430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APECO1_RS11435	COG1596	polysaccharide export
APECO1_RS11440	COG1253	flavin adenine dinucleotide binding
APECO1_RS11455	COG2982	Protein involved in outer membrane biogenesis
APECO1_RS11465	COG0572	uridine kinase
APECO1_RS11470	COG5002	protein histidine kinase activity
APECO1_RS11470	COG3447	MASE1 domain protein
APECO1_RS11470	COG5001	Diguanylate cyclase
APECO1_RS11475	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APECO1_RS11480	COG0443	Heat shock 70 kDa protein
APECO1_RS11485	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
APECO1_RS11490	COG0631	protein serine/threonine phosphatase activity
APECO1_RS11495	COG4245	von Willebrand factor, type A
APECO1_RS11520	COG2205	protein histidine kinase activity
APECO1_RS11525	COG0745	RESPONSE REGULATOR receiver
APECO1_RS11530	COG3422	double-strand break repair
APECO1_RS11555	COG0826	peptidase U32
APECO1_RS11600	COG1484	DNA-dependent DNA replication
APECO1_RS11635	COG4695	Portal protein
APECO1_RS11690	COG4974	Belongs to the 'phage' integrase family
APECO1_RS11715	COG1063	alcohol dehydrogenase
APECO1_RS11720	COG3775	system Galactitol-specific IIC component
APECO1_RS11725	COG3414	Phosphotransferase system galactitol-specific IIB component
APECO1_RS11730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS11745	COG1830	Aldolase
APECO1_RS11750	COG2211	Major facilitator Superfamily
APECO1_RS11755	COG1397	ADP-ribosylglycohydrolase
APECO1_RS11760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO1_RS11765	COG2188	Transcriptional regulator
APECO1_RS11770	COG3757	hydrolase, family 25
APECO1_RS11775	COG0351	phosphomethylpyrimidine kinase
APECO1_RS11795	COG5455	response to cobalt ion
APECO1_RS11800	COG3539	Fimbrial protein
APECO1_RS11805	COG3188	usher protein
APECO1_RS11810	COG3121	Chaperone
APECO1_RS11815	COG3539	Fimbrial protein
APECO1_RS11830	COG0489	protein tyrosine kinase activity
APECO1_RS11840	COG3831	ATPase activity
APECO1_RS11860	COG0714	Associated with various cellular activities
APECO1_RS11865	COG2425	protein containing a von Willebrand factor type A (vWA) domain
APECO1_RS11870	COG3552	Protein containing von Willebrand factor type A (VWA) domain
APECO1_RS11875	COG4715	Zinc finger, swim domain protein
APECO1_RS11880	COG4808	Protein conserved in bacteria
APECO1_RS11885	COG4807	Protein conserved in bacteria
APECO1_RS11890	COG3279	Response regulator of the LytR AlgR family
APECO1_RS11895	COG3275	phosphorelay sensor kinase activity
APECO1_RS11900	COG0789	Transcriptional regulator
APECO1_RS11910	COG1174	glycine betaine transport
APECO1_RS11915	COG1125	glycine betaine transport
APECO1_RS11920	COG1174	glycine betaine transport
APECO1_RS11925	COG1732	Glycine betaine
APECO1_RS11930	COG1472	Belongs to the glycosyl hydrolase 3 family
APECO1_RS11935	COG0277	FAD linked oxidase domain protein
APECO1_RS11940	COG1686	Belongs to the peptidase S11 family
APECO1_RS11950	COG0586	Pfam SNARE associated Golgi protein
APECO1_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS11960	COG1538	Outer membrane efflux protein
APECO1_RS11970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APECO1_RS11980	COG1346	cytolysis
APECO1_RS11990	COG2949	membrane
APECO1_RS12000	COG0493	'glutamate synthase
APECO1_RS12005	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APECO1_RS12005	COG0167	dihydroorotate dehydrogenase activity
APECO1_RS12010	COG4211	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS12020	COG1879	ABC-type sugar transport system periplasmic component
APECO1_RS12025	COG1609	Transcriptional regulator
APECO1_RS12035	COG2311	Membrane
APECO1_RS12055	COG4771	TonB-dependent receptor
APECO1_RS12065	COG0833	amino acid
APECO1_RS12070	COG0583	DNA-binding transcription factor activity
APECO1_RS12075	COG2855	membrane
APECO1_RS12085	COG1522	sequence-specific DNA binding
APECO1_RS12085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO1_RS12095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APECO1_RS12100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APECO1_RS12105	COG2313	pseudouridylate synthase activity
APECO1_RS12110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO1_RS12115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS12115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS12115	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APECO1_RS12120	COG1105	Belongs to the carbohydrate kinase PfkB family
APECO1_RS12125	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS12125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS12130	COG2814	Major facilitator Superfamily
APECO1_RS12145	COG0246	Mannitol dehydrogenase
APECO1_RS12150	COG0523	cobalamin synthesis protein
APECO1_RS12155	COG0671	phosphoesterase, PA-phosphatase related
APECO1_RS12160	COG0791	NLP P60 protein
APECO1_RS12165	COG2200	EAL domain
APECO1_RS12170	COG4166	transmembrane transport
APECO1_RS12175	COG4174	ABC transporter (Permease)
APECO1_RS12180	COG4239	(ABC) transporter, permease
APECO1_RS12185	COG4172	Belongs to the ABC transporter superfamily
APECO1_RS12195	COG2814	Major facilitator Superfamily
APECO1_RS12200	COG1187	pseudouridine synthase activity
APECO1_RS12205	COG1061	Type III restriction enzyme res subunit
APECO1_RS12225	COG3083	sulfuric ester hydrolase activity
APECO1_RS12235	COG3468	outer membrane autotransporter barrel domain protein
APECO1_RS12240	COG3468	outer membrane autotransporter barrel domain protein
APECO1_RS12250	COG2197	response regulator
APECO1_RS12255	COG3088	subunit of a heme lyase
APECO1_RS12255	COG4235	cytochrome complex assembly
APECO1_RS12260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APECO1_RS12265	COG1138	Cytochrome C-type biogenesis protein
APECO1_RS12275	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APECO1_RS12280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APECO1_RS12285	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APECO1_RS12295	COG3005	denitrification pathway
APECO1_RS12300	COG3043	anaerobic respiration
APECO1_RS12305	COG0348	domain, Protein
APECO1_RS12310	COG0437	4 iron, 4 sulfur cluster binding
APECO1_RS12320	COG3062	negative regulation of establishment of protein localization
APECO1_RS12325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO1_RS12325	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO1_RS12345	COG4615	Cyclic peptide transporter
APECO1_RS12350	COG3145	DNA-N1-methyladenine dioxygenase activity
APECO1_RS12355	COG2169	Transcriptional regulator
APECO1_RS12355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APECO1_RS12360	COG1477	protein flavinylation
APECO1_RS12365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APECO1_RS12375	COG0642	Histidine kinase
APECO1_RS12375	COG2198	Histidine kinase
APECO1_RS12380	COG2197	response regulator
APECO1_RS12385	COG2205	protein histidine kinase activity
APECO1_RS12385	COG0784	Response regulator, receiver
APECO1_RS12390	COG3852	Histidine kinase
APECO1_RS12395	COG2204	response regulator
APECO1_RS12400	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
APECO1_RS12405	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APECO1_RS12410	COG2031	fatty acid transporter
APECO1_RS12415	COG0183	Belongs to the thiolase family
APECO1_RS12420	COG4676	Protein conserved in bacteria
APECO1_RS12425	COG5445	Predicted secreted protein (DUF2300)
APECO1_RS12430	COG2373	Large extracellular alpha-helical protein
APECO1_RS12435	COG3234	Protein of unknown function (DUF1175)
APECO1_RS12440	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
APECO1_RS12445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APECO1_RS12455	COG3468	outer membrane autotransporter barrel domain protein
APECO1_RS12465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APECO1_RS12470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APECO1_RS12475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APECO1_RS12480	COG3642	lipopolysaccharide core region biosynthetic process
APECO1_RS12485	COG0584	glycerophosphoryl diester phosphodiesterase
APECO1_RS12490	COG2271	Major facilitator Superfamily
APECO1_RS12495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APECO1_RS12505	COG0247	lactate metabolic process
APECO1_RS12510	COG5464	transposase or invertase
APECO1_RS12525	COG2271	Major facilitator Superfamily
APECO1_RS12535	COG1414	Transcriptional regulator
APECO1_RS12600	COG0318	PFAM AMP-dependent synthetase and ligase
APECO1_RS12610	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APECO1_RS12625	COG1169	isochorismate synthase
APECO1_RS12630	COG4575	ribosome binding
APECO1_RS12635	COG2153	protein acetylation
APECO1_RS12645	COG2304	oxidoreductase activity
APECO1_RS12650	COG2234	aminopeptidase activity
APECO1_RS12665	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APECO1_RS12670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APECO1_RS12680	COG0839	Belongs to the complex I subunit 6 family
APECO1_RS12695	COG1034	ATP synthesis coupled electron transport
APECO1_RS12700	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APECO1_RS12705	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APECO1_RS12725	COG0583	DNA-binding transcription factor activity
APECO1_RS12730	COG0436	Aminotransferase
APECO1_RS12740	COG0490	domain, Protein
APECO1_RS12740	COG0471	metal ion transport
APECO1_RS12745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APECO1_RS12765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APECO1_RS12770	COG0857	belongs to the CobB CobQ family
APECO1_RS12770	COG0280	phosphate acetyltransferase
APECO1_RS12775	COG1288	antiporter activity
APECO1_RS12780	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
APECO1_RS12785	COG0622	Phosphoesterase
APECO1_RS12790	COG0625	glutathione transferase activity
APECO1_RS12795	COG0625	glutathione transferase activity
APECO1_RS12800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APECO1_RS12805	COG1090	epimerase
APECO1_RS12810	COG5464	transposase or invertase
APECO1_RS12815	COG4598	ABC transporter
APECO1_RS12820	COG4160	amino acid transport
APECO1_RS12825	COG4215	(ABC) transporter
APECO1_RS12830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO1_RS12835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO1_RS12840	COG0163	prenyltransferase activity
APECO1_RS12845	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APECO1_RS12850	COG1286	toxin biosynthetic process
APECO1_RS12855	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
APECO1_RS12860	COG0285	dihydrofolate synthase activity
APECO1_RS12870	COG0586	Pfam SNARE associated Golgi protein
APECO1_RS12880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APECO1_RS12895	COG2814	Major facilitator Superfamily
APECO1_RS12900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APECO1_RS12915	COG3101	peptidyl-lysine hydroxylation
APECO1_RS12920	COG0730	response to heat
APECO1_RS12955	COG3539	Fimbrial protein
APECO1_RS12960	COG3539	Fimbrial protein
APECO1_RS12965	COG3539	Fimbrial protein
APECO1_RS12970	COG3121	Chaperone
APECO1_RS12975	COG3188	usher protein
APECO1_RS12980	COG3539	Fimbrial protein
APECO1_RS12985	COG2062	phosphohistidine phosphatase, SixA
APECO1_RS13000	COG3691	Protein conserved in bacteria
APECO1_RS13005	COG2067	long-chain fatty acid transport protein
APECO1_RS13015	COG2116	formate transmembrane transporter activity
APECO1_RS13025	COG0582	viral genome integration into host DNA
APECO1_RS13130	COG1783	phage Terminase large subunit
APECO1_RS13145	COG3646	Phage regulatory protein
APECO1_RS13335	COG0583	DNA-binding transcription factor activity
APECO1_RS13340	COG2610	gluconate transmembrane transporter activity
APECO1_RS13350	COG0477	Major facilitator Superfamily
APECO1_RS13355	COG1566	PFAM secretion protein HlyD family protein
APECO1_RS13360	COG2197	response regulator
APECO1_RS13365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO1_RS13365	COG2198	Histidine kinase
APECO1_RS13365	COG0784	Response regulator, receiver
APECO1_RS13365	COG2205	protein histidine kinase activity
APECO1_RS13370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APECO1_RS13375	COG0679	Auxin Efflux Carrier
APECO1_RS13380	COG0028	Belongs to the TPP enzyme family
APECO1_RS13410	COG1560	Kdo2-lipid A biosynthetic process
APECO1_RS13415	COG0436	Aminotransferase
APECO1_RS13420	COG3275	phosphorelay sensor kinase activity
APECO1_RS13425	COG3279	Response regulator of the LytR AlgR family
APECO1_RS13430	COG2207	Transcriptional regulator
APECO1_RS13435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APECO1_RS13435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS13435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS13440	COG1363	Peptidase, m42
APECO1_RS13445	COG0006	proline dipeptidase activity
APECO1_RS13450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS13455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS13485	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APECO1_RS13490	COG2200	EAL domain
APECO1_RS13490	COG2199	diguanylate cyclase activity
APECO1_RS13505	COG3415	Transposase
APECO1_RS13510	COG3415	Transposase
APECO1_RS13540	COG0583	DNA-binding transcription factor activity
APECO1_RS13550	COG2211	Major facilitator Superfamily
APECO1_RS13555	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APECO1_RS13565	COG0583	DNA-binding transcription factor activity
APECO1_RS13570	COG0385	Bile acid
APECO1_RS13575	COG3530	Putative quorum-sensing-regulated virulence factor
APECO1_RS13595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APECO1_RS13600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS13605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APECO1_RS13610	COG2190	(PTS) system
APECO1_RS13625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APECO1_RS13630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APECO1_RS13635	COG4208	sulfate ABC transporter
APECO1_RS13640	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APECO1_RS13645	COG4150	thiosulfate binding
APECO1_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS13665	COG2837	iron assimilation
APECO1_RS13685	COG0860	N-Acetylmuramoyl-L-alanine amidase
APECO1_RS13695	COG2207	Transcriptional regulator
APECO1_RS13700	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APECO1_RS13705	COG4816	utilization protein
APECO1_RS13715	COG4303	Ethanolamine ammonia lyase large subunit
APECO1_RS13720	COG4819	ethanolamine utilization protein
APECO1_RS13725	COG3192	ethanolamine utilization protein
APECO1_RS13730	COG1454	alcohol dehydrogenase
APECO1_RS13735	COG4820	ethanolamine utilization protein (EutJ)
APECO1_RS13740	COG1012	belongs to the aldehyde dehydrogenase family
APECO1_RS13745	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
APECO1_RS13750	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APECO1_RS13755	COG0280	phosphate acetyltransferase
APECO1_RS13760	COG4812	Cobalamin adenosyltransferase
APECO1_RS13765	COG4766	ethanolamine catabolic process
APECO1_RS13770	COG4917	ethanolamine utilization protein
APECO1_RS13775	COG4810	utilization protein
APECO1_RS13780	COG0281	malic enzyme
APECO1_RS13780	COG0280	phosphate acetyltransferase
APECO1_RS13785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APECO1_RS13790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APECO1_RS13795	COG5342	invasion associated locus B
APECO1_RS13805	COG0493	'glutamate synthase
APECO1_RS13805	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO1_RS13810	COG3850	Histidine kinase
APECO1_RS13815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO1_RS13825	COG1393	Belongs to the ArsC family
APECO1_RS13840	COG0400	carboxylic ester hydrolase activity
APECO1_RS13850	COG2321	neutral zinc metallopeptidase
APECO1_RS13865	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
APECO1_RS13875	COG2716	regulation of RNA biosynthetic process
APECO1_RS13880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APECO1_RS13885	COG0628	permease
APECO1_RS13890	COG4783	chaperone-mediated protein folding
APECO1_RS13895	COG1393	Belongs to the ArsC family
APECO1_RS13905	COG2233	PERMEase
APECO1_RS13920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APECO1_RS13925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APECO1_RS13930	COG0248	Ppx GppA phosphatase
APECO1_RS13950	COG3133	Outer membrane lipoprotein
APECO1_RS13965	COG3179	chitinase
APECO1_RS14105	COG5484	DNA packaging
APECO1_RS14105	COG3728	DNA packaging
APECO1_RS14190	COG3723	Recombinational DNA repair protein, rece pathway
APECO1_RS14225	COG0517	IMP dehydrogenase activity
APECO1_RS14225	COG0516	GMP reductase activity
APECO1_RS14250	COG1645	bacterial-type flagellum-dependent swarming motility
APECO1_RS14265	COG2976	Protein conserved in bacteria
APECO1_RS14295	COG4953	penicillin-binding protein 1C
APECO1_RS14300	COG2373	Large extracellular alpha-helical protein
APECO1_RS14305	COG2897	thiosulfate sulfurtransferase activity
APECO1_RS14320	COG2975	iron-sulfur cluster assembly
APECO1_RS14325	COG0633	Ferredoxin
APECO1_RS14345	COG0822	iron-sulfur transferase activity
APECO1_RS14365	COG0483	inositol monophosphate 1-phosphatase activity
APECO1_RS14370	COG1073	alpha beta
APECO1_RS14375	COG3711	transcriptional antiterminator
APECO1_RS14380	COG2814	Major facilitator Superfamily
APECO1_RS14385	COG2259	Doxx family
APECO1_RS14390	COG2017	converts alpha-aldose to the beta-anomer
APECO1_RS14395	COG1063	alcohol dehydrogenase
APECO1_RS14400	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS14405	COG1129	ABC transporter
APECO1_RS14410	COG1879	ABC-type sugar transport system periplasmic component
APECO1_RS14415	COG0457	Tetratricopeptide repeat
APECO1_RS14420	COG1940	carbohydrate kinase activity
APECO1_RS14430	COG1017	nitric oxide dioxygenase activity
APECO1_RS14430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APECO1_RS14435	COG0347	Belongs to the P(II) protein family
APECO1_RS14440	COG2204	response regulator
APECO1_RS14445	COG3170	Tfp pilus assembly protein FimV
APECO1_RS14450	COG2205	protein histidine kinase activity
APECO1_RS14465	COG0590	tRNA wobble adenosine to inosine editing
APECO1_RS14470	COG0560	Phosphoserine phosphatase
APECO1_RS14475	COG1737	Transcriptional regulator
APECO1_RS14480	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO1_RS14500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APECO1_RS14520	COG0681	Belongs to the peptidase S26 family
APECO1_RS14530	COG3086	response to oxidative stress
APECO1_RS14535	COG3026	antisigma factor binding
APECO1_RS14540	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
APECO1_RS14545	COG1595	DNA-templated transcription, initiation
APECO1_RS14555	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APECO1_RS14565	COG0513	Belongs to the DEAD box helicase family
APECO1_RS14570	COG0583	DNA-binding transcription factor activity
APECO1_RS14600	COG3118	belongs to the thioredoxin family
APECO1_RS14605	COG3148	PFAM DTW domain containing protein
APECO1_RS14610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APECO1_RS14610	COG0045	succinate-CoA ligase (ADP-forming) activity
APECO1_RS14610	COG1042	CoA-binding domain protein
APECO1_RS14615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APECO1_RS14620	COG5544	Lipoprotein
APECO1_RS14625	COG0477	Major facilitator Superfamily
APECO1_RS14635	COG4584	PFAM Integrase catalytic
APECO1_RS14655	COG2801	Transposase and inactivated derivatives
APECO1_RS14695	COG0542	response to heat
APECO1_RS14705	COG0564	pseudouridine synthase activity
APECO1_RS14710	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APECO1_RS14720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APECO1_RS14725	COG0077	Prephenate dehydratase
APECO1_RS14725	COG1605	Chorismate mutase
APECO1_RS14730	COG1605	Chorismate mutase
APECO1_RS14730	COG0287	Prephenate dehydrogenase
APECO1_RS14735	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APECO1_RS14750	COG2199	diguanylate cyclase activity
APECO1_RS14755	COG2885	chlorophyll binding
APECO1_RS14780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APECO1_RS14785	COG4137	Cytochrome C assembly protein
APECO1_RS14790	COG4536	flavin adenine dinucleotide binding
APECO1_RS14805	COG0497	DNA recombination
APECO1_RS14810	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APECO1_RS14820	COG2867	negative regulation of translational initiation
APECO1_RS14860	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APECO1_RS14870	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APECO1_RS14885	COG3778	Protein conserved in bacteria
APECO1_RS14890	COG3299	homolog of phage Mu protein gp47
APECO1_RS14910	COG4228	DNA circulation
APECO1_RS14930	COG4386	tail sheath protein
APECO1_RS14975	COG4695	Portal protein
APECO1_RS14985	COG1802	Transcriptional regulator
APECO1_RS14985	COG4626	Terminase
APECO1_RS15030	COG0484	heat shock protein binding
APECO1_RS15035	COG1403	HNH endonuclease
APECO1_RS15045	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APECO1_RS15055	COG4725	Belongs to the MT-A70-like family
APECO1_RS15065	COG1846	Transcriptional regulator
APECO1_RS15080	COG4197	protein conserved in bacteria, prophage-related
APECO1_RS15085	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APECO1_RS15105	COG5532	Uncharacterized conserved protein (DUF2303)
APECO1_RS15110	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
APECO1_RS15120	COG0582	viral genome integration into host DNA
APECO1_RS15150	COG0579	oxidoreductase
APECO1_RS15155	COG1012	belongs to the aldehyde dehydrogenase family
APECO1_RS15160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APECO1_RS15165	COG1113	amino acid transport
APECO1_RS15170	COG1802	Transcriptional regulator
APECO1_RS15175	COG1652	LysM domain
APECO1_RS15180	COG0401	homolog of Blt101
APECO1_RS15185	COG0640	Transcriptional regulator
APECO1_RS15190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APECO1_RS15195	COG2916	Histone family protein nucleoid-structuring protein H-NS
APECO1_RS15210	COG4575	ribosome binding
APECO1_RS15220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APECO1_RS15225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APECO1_RS15235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APECO1_RS15240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APECO1_RS15245	COG4175	Glycine betaine
APECO1_RS15250	COG4176	ABC-type proline glycine betaine transport system permease component
APECO1_RS15255	COG2113	Glycine betaine
APECO1_RS15260	COG2814	Major facilitator Superfamily
APECO1_RS15265	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
APECO1_RS15275	COG1846	Transcriptional regulator
APECO1_RS15280	COG1566	PFAM secretion protein HlyD family protein
APECO1_RS15285	COG2814	Major facilitator Superfamily
APECO1_RS15310	COG1238	metal cluster binding
APECO1_RS15315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APECO1_RS15350	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APECO1_RS15375	COG1546	Belongs to the CinA family
APECO1_RS15380	COG2951	lytic endotransglycosylase activity
APECO1_RS15385	COG3730	PTS system glucitol sorbitol-specific
APECO1_RS15390	COG3732	PTS system glucitol sorbitol-specific
APECO1_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS15405	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS15410	COG1349	DNA-binding transcription factor activity
APECO1_RS15415	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APECO1_RS15415	COG0517	IMP dehydrogenase activity
APECO1_RS15435	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APECO1_RS15440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO1_RS15445	COG1609	Transcriptional regulator
APECO1_RS15450	COG1263	PTS System
APECO1_RS15450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS15455	COG2723	6-phospho-beta-galactosidase activity
APECO1_RS15460	COG5499	transcription regulator containing HTH domain
APECO1_RS15465	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APECO1_RS15475	COG3260	NADH ubiquinone oxidoreductase 20
APECO1_RS15480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APECO1_RS15485	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
APECO1_RS15485	COG3261	NADH dehydrogenase
APECO1_RS15490	COG0650	Formate hydrogenlyase subunit 4
APECO1_RS15495	COG0651	ATP synthesis coupled electron transport
APECO1_RS15500	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO1_RS15510	COG0375	protein maturation
APECO1_RS15515	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APECO1_RS15520	COG0298	carbon dioxide binding
APECO1_RS15525	COG0409	Hydrogenase expression formation protein
APECO1_RS15530	COG0309	Hydrogenase expression formation protein (HypE)
APECO1_RS15535	COG3604	Transcriptional regulator
APECO1_RS15555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APECO1_RS15560	COG1349	DNA-binding transcription factor activity
APECO1_RS15565	COG2084	Dehydrogenase
APECO1_RS15570	COG3395	kinase activity
APECO1_RS15575	COG0235	Class ii aldolase
APECO1_RS15580	COG3622	Belongs to the hyi family
APECO1_RS15585	COG2610	gluconate transmembrane transporter activity
APECO1_RS15600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APECO1_RS15605	COG1388	LysM domain
APECO1_RS15605	COG4942	peptidase
APECO1_RS15660	COG2234	aminopeptidase activity
APECO1_RS15685	COG0720	synthase
APECO1_RS15690	COG0644	oxidoreductase
APECO1_RS15695	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
APECO1_RS15700	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
APECO1_RS15705	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APECO1_RS15710	COG2086	electron transfer activity
APECO1_RS15715	COG0477	Major facilitator Superfamily
APECO1_RS15720	COG0277	FAD linked oxidase domain protein
APECO1_RS15725	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS15730	COG2223	nitrite transmembrane transporter activity
APECO1_RS15735	COG1070	Carbohydrate kinase
APECO1_RS15745	COG0602	queuosine metabolic process
APECO1_RS15765	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APECO1_RS15780	COG3956	TIGRFAM MazG family protein
APECO1_RS15785	COG2337	Toxic component of a toxin-antitoxin (TA) module
APECO1_RS15790	COG2336	PFAM SpoVT AbrB
APECO1_RS15795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APECO1_RS15805	COG3437	response regulator, receiver
APECO1_RS15805	COG3850	Histidine kinase
APECO1_RS15805	COG4999	Histidine kinase
APECO1_RS15805	COG2205	protein histidine kinase activity
APECO1_RS15810	COG4948	Mandelate Racemase Muconate Lactonizing
APECO1_RS15815	COG4948	Mandelate Racemase Muconate Lactonizing
APECO1_RS15820	COG2271	Major facilitator Superfamily
APECO1_RS15825	COG0716	FMN binding
APECO1_RS15830	COG0564	pseudouridine synthase activity
APECO1_RS15835	COG3098	single-species biofilm formation
APECO1_RS15855	COG1611	Belongs to the LOG family
APECO1_RS15860	COG0814	amino acid
APECO1_RS15865	COG1760	l-serine dehydratase
APECO1_RS15875	COG1454	alcohol dehydrogenase
APECO1_RS15880	COG0235	Class ii aldolase
APECO1_RS15885	COG0738	Major facilitator superfamily
APECO1_RS15895	COG1070	Carbohydrate kinase
APECO1_RS15905	COG1349	DNA-binding transcription factor activity
APECO1_RS15915	COG2363	Small membrane protein
APECO1_RS15920	COG0583	DNA-binding transcription factor activity
APECO1_RS15930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APECO1_RS15935	COG2166	iron-sulfur cluster assembly
APECO1_RS15940	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APECO1_RS15945	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APECO1_RS15985	COG2885	chlorophyll binding
APECO1_RS16040	COG1484	DNA-dependent DNA replication
APECO1_RS16045	COG4584	PFAM Integrase catalytic
APECO1_RS16105	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APECO1_RS16110	COG1263	PTS System
APECO1_RS16110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS16115	COG3711	transcriptional antiterminator
APECO1_RS16120	COG0860	N-Acetylmuramoyl-L-alanine amidase
APECO1_RS16125	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APECO1_RS16125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APECO1_RS16130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APECO1_RS16135	COG1074	ATP-dependent DNA helicase activity
APECO1_RS16140	COG1025	Belongs to the peptidase M16 family
APECO1_RS16145	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APECO1_RS16150	COG4967	type IV pilus modification protein PilV
APECO1_RS16160	COG4795	General secretion pathway protein
APECO1_RS16165	COG2165	general secretion pathway protein
APECO1_RS16180	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
APECO1_RS16205	COG0861	Integral membrane protein TerC family
APECO1_RS16215	COG0667	Aldo Keto reductase
APECO1_RS16230	COG1609	Transcriptional regulator
APECO1_RS16240	COG0583	DNA-binding transcription factor activity
APECO1_RS16245	COG1794	racemase activity, acting on amino acids and derivatives
APECO1_RS16250	COG2814	Major facilitator Superfamily
APECO1_RS16255	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS16265	COG0183	Belongs to the thiolase family
APECO1_RS16270	COG0814	amino acid
APECO1_RS16280	COG4942	peptidase
APECO1_RS16285	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APECO1_RS16290	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APECO1_RS16295	COG2080	2 iron, 2 sulfur cluster binding
APECO1_RS16300	COG3829	transcription factor binding
APECO1_RS16305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APECO1_RS16310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APECO1_RS16315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APECO1_RS16325	COG0549	Belongs to the carbamate kinase family
APECO1_RS16330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APECO1_RS16330	COG3608	succinylglutamate desuccinylase aspartoacylase
APECO1_RS16335	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APECO1_RS16340	COG2068	MobA-Related Protein
APECO1_RS16345	COG0493	'glutamate synthase
APECO1_RS16345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO1_RS16350	COG0402	S-adenosylhomocysteine deaminase activity
APECO1_RS16355	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APECO1_RS16360	COG2080	2 iron, 2 sulfur cluster binding
APECO1_RS16360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APECO1_RS16365	COG2233	PERMEase
APECO1_RS16370	COG0402	S-adenosylhomocysteine deaminase activity
APECO1_RS16375	COG2252	PERMEase
APECO1_RS16380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO1_RS16385	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO1_RS16385	COG0493	'glutamate synthase
APECO1_RS16395	COG2233	PERMEase
APECO1_RS16410	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APECO1_RS16420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APECO1_RS16425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APECO1_RS16435	COG0716	FMN binding
APECO1_RS16445	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APECO1_RS16455	COG1272	protein, Hemolysin III
APECO1_RS16465	COG2723	6-phospho-beta-galactosidase activity
APECO1_RS16485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APECO1_RS16490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APECO1_RS16495	COG0006	proline dipeptidase activity
APECO1_RS16510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APECO1_RS16515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APECO1_RS16535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APECO1_RS16535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APECO1_RS16540	COG0583	DNA-binding transcription factor activity
APECO1_RS16545	COG2968	Membrane
APECO1_RS16550	COG1279	arginine transmembrane transporter activity
APECO1_RS16555	COG0668	transmembrane transport
APECO1_RS16560	COG0191	fructose-bisphosphate aldolase activity
APECO1_RS16595	COG1122	ATPase activity
APECO1_RS16600	COG1072	(Pantothenic acid kinase))
APECO1_RS16610	COG1494	fructose-1,6-bisphosphatase
APECO1_RS16615	COG1063	alcohol dehydrogenase
APECO1_RS16620	COG2213	PTS system mannitol-specific
APECO1_RS16625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS16630	COG0330	HflC and HflK could
APECO1_RS16635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APECO1_RS16640	COG0501	Belongs to the peptidase M48B family
APECO1_RS16655	COG1166	arginine decarboxylase activity
APECO1_RS16680	COG2814	Major facilitator Superfamily
APECO1_RS16690	COG2356	endonuclease I
APECO1_RS16695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APECO1_RS16700	COG0189	ligase activity
APECO1_RS16715	COG2805	Type II/IV secretion system protein
APECO1_RS16720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APECO1_RS16725	COG0762	integral membrane protein
APECO1_RS16735	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APECO1_RS16740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APECO1_RS16750	COG0252	asparaginase activity
APECO1_RS16765	COG3171	Protein conserved in bacteria
APECO1_RS16775	COG1194	a g-specific adenine glycosylase
APECO1_RS16790	COG2211	Major facilitator Superfamily
APECO1_RS16795	COG1982	Orn Lys Arg decarboxylase major
APECO1_RS16800	COG1811	Na channel or pump
APECO1_RS16810	COG0582	viral genome integration into host DNA
APECO1_RS16815	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
APECO1_RS16815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APECO1_RS16820	COG2194	sulfuric ester hydrolase activity
APECO1_RS16830	COG1484	DNA-dependent DNA replication
APECO1_RS16835	COG4584	PFAM Integrase catalytic
APECO1_RS16975	COG3969	phosphoadenosine phosphosulfate
APECO1_RS17010	COG4771	TonB-dependent receptor
APECO1_RS17040	COG3596	GTP binding
APECO1_RS17050	COG2378	regulation of single-species biofilm formation
APECO1_RS17075	COG2003	Belongs to the UPF0758 family
APECO1_RS17110	COG2771	luxR family
APECO1_RS17110	COG2200	EAL domain
APECO1_RS17170	COG2089	acid synthase
APECO1_RS17190	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
APECO1_RS17220	COG2165	general secretion pathway protein
APECO1_RS17225	COG1459	type II secretion system
APECO1_RS17230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APECO1_RS17240	COG3031	protein transport across the cell outer membrane
APECO1_RS17255	COG3064	Membrane
APECO1_RS17265	COG1620	l-lactate permease
APECO1_RS17270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APECO1_RS17275	COG3193	protein, possibly involved in utilization of glycolate and propanediol
APECO1_RS17280	COG0247	lactate metabolic process
APECO1_RS17285	COG0277	FAD linked oxidase domain protein
APECO1_RS17290	COG0277	FAD linked oxidase domain protein
APECO1_RS17295	COG2186	Transcriptional regulator
APECO1_RS17300	COG0456	acetyltransferase
APECO1_RS17305	COG0318	PFAM AMP-dependent synthetase and ligase
APECO1_RS17315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APECO1_RS17320	COG0156	8-amino-7-oxononanoate synthase activity
APECO1_RS17330	COG0795	lipopolysaccharide-transporting ATPase activity
APECO1_RS17335	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APECO1_RS17345	COG2244	polysaccharide biosynthetic process
APECO1_RS17350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APECO1_RS17355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APECO1_RS17360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APECO1_RS17365	COG0306	phosphate transporter
APECO1_RS17370	COG0754	glutathionylspermidine amidase activity
APECO1_RS17375	COG0625	glutathione transferase activity
APECO1_RS17380	COG0298	carbon dioxide binding
APECO1_RS17385	COG0375	protein maturation
APECO1_RS17390	COG1773	rubredoxin
APECO1_RS17395	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APECO1_RS17400	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APECO1_RS17405	COG5557	Pfam Polysulphide reductase, NrfD
APECO1_RS17410	COG0437	4 iron, 4 sulfur cluster binding
APECO1_RS17415	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APECO1_RS17435	COG0667	Aldo Keto reductase
APECO1_RS17445	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS17450	COG0848	biopolymer transport protein
APECO1_RS17455	COG0811	peptide transport
APECO1_RS17465	COG0626	cystathionine gamma-synthase activity
APECO1_RS17470	COG0586	Pfam SNARE associated Golgi protein
APECO1_RS17475	COG2207	Transcriptional regulator
APECO1_RS17485	COG1979	alcohol dehydrogenase
APECO1_RS17490	COG0656	L-ascorbic acid biosynthetic process
APECO1_RS17500	COG4238	major outer membrane lipoprotein
APECO1_RS17505	COG1032	radical SAM domain protein
APECO1_RS17510	COG2186	Transcriptional regulator
APECO1_RS17515	COG0246	Mannitol dehydrogenase
APECO1_RS17520	COG1063	alcohol dehydrogenase
APECO1_RS17525	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APECO1_RS17545	COG2132	Multicopper oxidase
APECO1_RS17550	COG0204	Acyl-transferase
APECO1_RS17555	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APECO1_RS17560	COG4166	transmembrane transport
APECO1_RS17565	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
APECO1_RS17570	COG3111	PFAM Bacterial OB fold (BOF) protein
APECO1_RS17575	COG0745	RESPONSE REGULATOR receiver
APECO1_RS17580	COG0642	Histidine kinase
APECO1_RS17600	COG2249	NAD(P)H dehydrogenase (quinone) activity
APECO1_RS17605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
APECO1_RS17610	COG1737	Transcriptional regulator
APECO1_RS17620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO1_RS17625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO1_RS17630	COG1120	ATPase activity
APECO1_RS17635	COG4774	siderophore transport
APECO1_RS17640	COG0187	DNA topoisomerase II activity
APECO1_RS17645	COG3150	esterase
APECO1_RS17650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APECO1_RS17655	COG3151	Protein conserved in bacteria
APECO1_RS17660	COG0494	nUDIX hydrolase
APECO1_RS17665	COG1538	Outer membrane efflux protein
APECO1_RS17680	COG0754	glutathionylspermidine amidase activity
APECO1_RS17690	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
APECO1_RS17700	COG3384	dioxygenase
APECO1_RS17715	COG3539	Fimbrial protein
APECO1_RS17720	COG3188	usher protein
APECO1_RS17725	COG3121	Chaperone
APECO1_RS17730	COG3539	Fimbrial protein
APECO1_RS17750	COG1585	Membrane protein implicated in regulation of membrane protease activity
APECO1_RS17755	COG2268	Band 7 protein
APECO1_RS17775	COG3025	triphosphatase activity
APECO1_RS17785	COG4991	sh3 domain protein
APECO1_RS17800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APECO1_RS17820	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO1_RS17835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APECO1_RS17840	COG0358	DNA primase activity
APECO1_RS17845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APECO1_RS17860	COG2375	cellular response to nickel ion
APECO1_RS17865	COG1695	Transcriptional regulator
APECO1_RS17870	COG0840	transmembrane signaling receptor activity
APECO1_RS17880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APECO1_RS17885	COG1609	Transcriptional regulator
APECO1_RS17890	COG3250	beta-galactosidase activity
APECO1_RS17895	COG2731	YhcH YjgK YiaL family protein
APECO1_RS17900	COG0531	amino acid
APECO1_RS17910	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
APECO1_RS17910	COG3408	Glycogen debranching enzyme
APECO1_RS17915	COG0446	pyridine nucleotide-disulphide oxidoreductase
APECO1_RS17915	COG1902	pentaerythritol trinitrate reductase activity
APECO1_RS17925	COG1451	nucleotide metabolic process
APECO1_RS17930	COG2949	membrane
APECO1_RS17935	COG0673	inositol 2-dehydrogenase activity
APECO1_RS17940	COG0861	Integral membrane protein TerC family
APECO1_RS17955	COG2721	sulfolactate sulfo-lyase activity
APECO1_RS17965	COG2271	Major facilitator Superfamily
APECO1_RS17970	COG2186	Transcriptional regulator
APECO1_RS17975	COG0586	Pfam SNARE associated Golgi protein
APECO1_RS17985	COG1422	Protein of unknown function (DUF1090)
APECO1_RS17990	COG4575	ribosome binding
APECO1_RS17995	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
APECO1_RS18005	COG2259	Doxx family
APECO1_RS18010	COG0435	Glutathione S-transferase
APECO1_RS18015	COG3152	Membrane
APECO1_RS18020	COG0583	DNA-binding transcription factor activity
APECO1_RS18025	COG1741	Belongs to the pirin family
APECO1_RS18040	COG0814	amino acid
APECO1_RS18045	COG1760	l-serine dehydratase
APECO1_RS18050	COG0251	oxidation-reduction process
APECO1_RS18055	COG1882	Formate acetyltransferase
APECO1_RS18060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APECO1_RS18070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APECO1_RS18075	COG0583	DNA-binding transcription factor activity
APECO1_RS18085	COG1929	Belongs to the glycerate kinase type-1 family
APECO1_RS18090	COG2084	Dehydrogenase
APECO1_RS18100	COG2271	Major facilitator Superfamily
APECO1_RS18105	COG2721	sulfolactate sulfo-lyase activity
APECO1_RS18110	COG1349	DNA-binding transcription factor activity
APECO1_RS18120	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS18130	COG3716	PTS system mannose fructose sorbose family IID component
APECO1_RS18135	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS18140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APECO1_RS18145	COG2222	sugar isomerase
APECO1_RS18155	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS18160	COG3715	PTS system
APECO1_RS18165	COG3716	PTS system mannose fructose sorbose family IID component
APECO1_RS18170	COG0363	glucosamine-6-phosphate deaminase activity
APECO1_RS18175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APECO1_RS18180	COG3107	peptidoglycan biosynthetic process
APECO1_RS18195	COG2823	Periplasmic or secreted lipoprotein
APECO1_RS18200	COG0701	Predicted permease
APECO1_RS18205	COG0702	epimerase
APECO1_RS18210	COG0693	protein deglycase activity
APECO1_RS18225	COG3153	acetyltransferase
APECO1_RS18230	COG3154	lipid carrier protein
APECO1_RS18235	COG0826	peptidase U32
APECO1_RS18240	COG0826	peptidase U32
APECO1_RS18245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APECO1_RS18250	COG0814	amino acid
APECO1_RS18260	COG0513	Belongs to the DEAD box helicase family
APECO1_RS18295	COG0195	Participates in both transcription termination and antitermination
APECO1_RS18315	COG2194	sulfuric ester hydrolase activity
APECO1_RS18325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APECO1_RS18335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APECO1_RS18340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APECO1_RS18350	COG1534	Rna-binding protein
APECO1_RS18355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APECO1_RS18360	COG2027	D-alanyl-D-alanine carboxypeptidase
APECO1_RS18370	COG0697	spore germination
APECO1_RS18385	COG0142	geranyltranstransferase activity
APECO1_RS18390	COG3423	Transcriptional regulator
APECO1_RS18400	COG5007	Belongs to the BolA IbaG family
APECO1_RS18405	COG3113	response to antibiotic
APECO1_RS18410	COG2854	intermembrane phospholipid transfer
APECO1_RS18415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APECO1_RS18420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APECO1_RS18425	COG1127	ABC transporter
APECO1_RS18430	COG0530	calcium, potassium:sodium antiporter activity
APECO1_RS18435	COG0517	IMP dehydrogenase activity
APECO1_RS18435	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APECO1_RS18440	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APECO1_RS18445	COG3117	lipopolysaccharide transmembrane transporter activity
APECO1_RS18450	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APECO1_RS18455	COG1137	ATPase activity
APECO1_RS18460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APECO1_RS18465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APECO1_RS18480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS18485	COG0515	serine threonine protein kinase
APECO1_RS18495	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
APECO1_RS18500	COG5002	protein histidine kinase activity
APECO1_RS18500	COG0784	Response regulator, receiver
APECO1_RS18500	COG2198	Histidine kinase
APECO1_RS18505	COG1242	4 iron, 4 sulfur cluster binding
APECO1_RS18510	COG0067	glutamate synthase
APECO1_RS18510	COG0070	glutamate synthase
APECO1_RS18510	COG0069	glutamate synthase activity
APECO1_RS18515	COG0493	'glutamate synthase
APECO1_RS18520	COG2731	YhcH YjgK YiaL family protein
APECO1_RS18550	COG2969	positive regulation of protein catabolic process
APECO1_RS18555	COG0625	glutathione transferase activity
APECO1_RS18570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APECO1_RS18575	COG3105	Protein conserved in bacteria
APECO1_RS18580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APECO1_RS18585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APECO1_RS18605	COG2732	(Barnase) inhibitor
APECO1_RS18625	COG0583	DNA-binding transcription factor activity
APECO1_RS18630	COG0312	modulator of DNA gyrase
APECO1_RS18635	COG3164	Protein of unknown function
APECO1_RS18640	COG1530	ribonuclease E activity
APECO1_RS18650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APECO1_RS18655	COG1792	Involved in formation and maintenance of cell shape
APECO1_RS18660	COG1077	Cell shape determining protein MreB Mrl
APECO1_RS18670	COG2199	diguanylate cyclase activity
APECO1_RS18670	COG2200	EAL domain
APECO1_RS18675	COG0604	alcohol dehydrogenase
APECO1_RS18695	COG0511	ligase activity, forming carbon-carbon bonds
APECO1_RS18700	COG0439	Biotin carboxylase
APECO1_RS18710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO1_RS18715	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS18720	COG1129	ABC transporter
APECO1_RS18725	COG1879	ABC-type sugar transport system periplasmic component
APECO1_RS18735	COG1349	DNA-binding transcription factor activity
APECO1_RS18745	COG3924	membrane
APECO1_RS18750	COG4145	pantothenate transmembrane transporter activity
APECO1_RS18760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APECO1_RS18770	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APECO1_RS18780	COG1309	transcriptional regulator
APECO1_RS18785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO1_RS18790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO1_RS18810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO1_RS18815	COG4597	amino acid ABC transporter
APECO1_RS18820	COG0765	amino acid transport
APECO1_RS18825	COG1126	abc transporter atp-binding protein
APECO1_RS18865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APECO1_RS18885	COG0551	DNA topoisomerase type I activity
APECO1_RS18895	COG0758	DNA mediated transformation
APECO1_RS18915	COG0569	domain protein
APECO1_RS18925	COG3036	rescue of stalled ribosome
APECO1_RS18930	COG0789	Transcriptional regulator
APECO1_RS18970	COG0201	protein transport
APECO1_RS19060	COG0089	rRNA binding
APECO1_RS19090	COG3031	protein transport across the cell outer membrane
APECO1_RS19095	COG1450	Type ii and iii secretion system protein
APECO1_RS19100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APECO1_RS19110	COG1459	type II secretion system
APECO1_RS19115	COG2165	general secretion pathway protein
APECO1_RS19120	COG2165	general secretion pathway protein
APECO1_RS19125	COG2165	general secretion pathway protein
APECO1_RS19130	COG4795	General secretion pathway protein
APECO1_RS19140	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
APECO1_RS19145	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
APECO1_RS19150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APECO1_RS19155	COG2193	ferroxidase activity
APECO1_RS19160	COG2906	2 iron, 2 sulfur cluster binding
APECO1_RS19165	COG3979	chitinase
APECO1_RS19205	COG2964	Protein conserved in bacteria
APECO1_RS19210	COG0545	Peptidyl-prolyl cis-trans isomerase
APECO1_RS19220	COG1047	Peptidyl-prolyl cis-trans
APECO1_RS19225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
APECO1_RS19240	COG0488	(ABC) transporter
APECO1_RS19245	COG0429	hydrolase of the alpha beta-hydrolase fold
APECO1_RS19255	COG3954	Phosphoribulokinase
APECO1_RS19260	COG1765	OsmC-like protein
APECO1_RS19270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APECO1_RS19275	COG1289	transmembrane transporter activity
APECO1_RS19280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APECO1_RS19285	COG0512	Glutamine amidotransferase of anthranilate synthase
APECO1_RS19290	COG2184	nucleotidyltransferase activity
APECO1_RS19300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APECO1_RS19310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APECO1_RS19315	COG2146	nitrite reductase [NAD(P)H] activity
APECO1_RS19320	COG2116	formate transmembrane transporter activity
APECO1_RS19335	COG0626	cystathionine gamma-synthase activity
APECO1_RS19350	COG1735	metal-dependent hydrolase with the TIM-barrel fold
APECO1_RS19355	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
APECO1_RS19360	COG3457	Alanine racemase
APECO1_RS19370	COG2188	Transcriptional regulator
APECO1_RS19375	COG0180	Tryptophanyl-tRNA synthetase
APECO1_RS19380	COG0546	phosphoglycolate phosphatase activity
APECO1_RS19385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APECO1_RS19390	COG0338	D12 class N6 adenine-specific DNA methyltransferase
APECO1_RS19395	COG3266	domain, Protein
APECO1_RS19410	COG4796	Type ii and iii secretion system protein
APECO1_RS19425	COG3166	PFAM Fimbrial assembly family protein
APECO1_RS19430	COG4972	Pilus assembly protein
APECO1_RS19435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APECO1_RS19440	COG0494	nUDIX hydrolase
APECO1_RS19450	COG1011	Hydrolase
APECO1_RS19455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APECO1_RS19465	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
APECO1_RS19490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APECO1_RS19495	COG2183	response to ionizing radiation
APECO1_RS19500	COG1918	ferrous iron import across plasma membrane
APECO1_RS19505	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
APECO1_RS19515	COG5464	transposase or invertase
APECO1_RS19525	COG1040	competence protein
APECO1_RS19535	COG2610	gluconate transmembrane transporter activity
APECO1_RS19540	COG1640	4-alpha-glucanotransferase
APECO1_RS19545	COG0058	SHG alpha-glucan phosphorylase activity
APECO1_RS19560	COG1690	Belongs to the RtcB family
APECO1_RS19565	COG4650	regulator
APECO1_RS19570	COG1349	DNA-binding transcription factor activity
APECO1_RS19585	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APECO1_RS19625	COG3188	usher protein
APECO1_RS19630	COG3121	Chaperone
APECO1_RS19640	COG0058	SHG alpha-glucan phosphorylase activity
APECO1_RS19665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APECO1_RS19670	COG2095	MarC family integral membrane protein
APECO1_RS19680	COG3265	gluconokinase activity
APECO1_RS19685	COG1609	Transcriptional regulator
APECO1_RS19690	COG1741	Belongs to the pirin family
APECO1_RS19695	COG0673	inositol 2-dehydrogenase activity
APECO1_RS19705	COG1247	-acetyltransferase
APECO1_RS19725	COG0405	Gamma-glutamyltransferase
APECO1_RS19735	COG0584	glycerophosphoryl diester phosphodiesterase
APECO1_RS19765	COG0410	ABC transporter
APECO1_RS19770	COG0411	ABC transporter
APECO1_RS19775	COG4177	L-phenylalanine transmembrane transporter activity
APECO1_RS19780	COG0559	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS19785	COG0683	leucine binding
APECO1_RS19790	COG0456	acetyltransferase
APECO1_RS19800	COG0683	leucine binding
APECO1_RS19830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APECO1_RS19835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APECO1_RS19840	COG2177	Part of the ABC transporter FtsEX involved in
APECO1_RS19845	COG2884	Cell division ATP-binding protein ftsE
APECO1_RS19850	COG0552	protein localization to endoplasmic reticulum
APECO1_RS19855	COG0742	ribosomal rna small subunit methyltransferase
APECO1_RS19860	COG3776	membrane
APECO1_RS19870	COG3714	YhhN family
APECO1_RS19885	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APECO1_RS19895	COG0477	Major facilitator Superfamily
APECO1_RS19900	COG0628	permease
APECO1_RS19905	COG2091	lysine biosynthetic process via aminoadipic acid
APECO1_RS19910	COG0747	negative chemotaxis
APECO1_RS19915	COG0601	transmembrane transport
APECO1_RS19920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APECO1_RS19940	COG2188	Transcriptional regulator
APECO1_RS19950	COG3414	Phosphotransferase system galactitol-specific IIB component
APECO1_RS19955	COG3775	system Galactitol-specific IIC component
APECO1_RS19970	COG0191	fructose-bisphosphate aldolase activity
APECO1_RS19975	COG0842	Transport permease protein
APECO1_RS19980	COG1129	ABC transporter
APECO1_RS19980	COG0842	Transport permease protein
APECO1_RS19985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO1_RS19995	COG2081	HI0933 family
APECO1_RS20000	COG0306	phosphate transporter
APECO1_RS20010	COG0589	response to stress
APECO1_RS20015	COG3104	oligopeptide transport
APECO1_RS20025	COG0339	signal peptide processing
APECO1_RS20030	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APECO1_RS20035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APECO1_RS20050	COG1393	Belongs to the ArsC family
APECO1_RS20055	COG3065	identical protein binding
APECO1_RS20060	COG2197	response regulator
APECO1_RS20065	COG3720	iron ion transport
APECO1_RS20070	COG4771	TonB-dependent receptor
APECO1_RS20090	COG3721	Heme iron utilization protein
APECO1_RS20100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO1_RS20110	COG1285	pathogenesis
APECO1_RS20125	COG3247	response to pH
APECO1_RS20130	COG2771	luxR family
APECO1_RS20140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO1_RS20145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO1_RS20150	COG2207	Transcriptional regulator
APECO1_RS20155	COG2207	Transcriptional regulator
APECO1_RS20160	COG0076	glutamate decarboxylase activity
APECO1_RS20165	COG1858	cytochrome C peroxidase
APECO1_RS20175	COG2197	response regulator
APECO1_RS20180	COG0583	DNA-binding transcription factor activity
APECO1_RS20185	COG1295	ribonuclease BN
APECO1_RS20190	COG0477	Major facilitator Superfamily
APECO1_RS20195	COG2982	Protein involved in outer membrane biogenesis
APECO1_RS20200	COG2200	EAL domain
APECO1_RS20210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO1_RS20215	COG0612	Peptidase, M16
APECO1_RS20225	COG2199	diguanylate cyclase activity
APECO1_RS20225	COG2200	EAL domain
APECO1_RS20230	COG0457	Tetratricopeptide repeat
APECO1_RS20230	COG3118	belongs to the thioredoxin family
APECO1_RS20235	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
APECO1_RS20240	COG1215	transferase activity, transferring glycosyl groups
APECO1_RS20245	COG1215	transferase activity, transferring glycosyl groups
APECO1_RS20270	COG2194	sulfuric ester hydrolase activity
APECO1_RS20300	COG0814	amino acid
APECO1_RS20305	COG4608	Belongs to the ABC transporter superfamily
APECO1_RS20310	COG0444	Belongs to the ABC transporter superfamily
APECO1_RS20315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APECO1_RS20320	COG0601	transmembrane transport
APECO1_RS20330	COG0747	negative chemotaxis
APECO1_RS20345	COG2194	sulfuric ester hydrolase activity
APECO1_RS20350	COG2223	nitrite transmembrane transporter activity
APECO1_RS20355	COG5571	outer membrane autotransporter
APECO1_RS20360	COG2818	Glycosylase
APECO1_RS20365	COG0456	acetyltransferase
APECO1_RS20370	COG0243	molybdopterin cofactor binding
APECO1_RS20375	COG2885	chlorophyll binding
APECO1_RS20390	COG2944	sequence-specific DNA binding
APECO1_RS20395	COG1278	Cold shock
APECO1_RS20420	COG3274	enterobacterial common antigen metabolic process
APECO1_RS20425	COG4682	membrane
APECO1_RS20430	COG4682	membrane
APECO1_RS20435	COG1070	Carbohydrate kinase
APECO1_RS20445	COG4213	ABC transporter substrate-binding protein
APECO1_RS20455	COG4214	carbohydrate transport
APECO1_RS20460	COG1609	Transcriptional regulator
APECO1_RS20460	COG2207	Transcriptional regulator
APECO1_RS20465	COG2992	FlgJ-related protein
APECO1_RS20470	COG0366	Alpha amylase catalytic
APECO1_RS20475	COG3977	Valine--pyruvate aminotransferase
APECO1_RS20485	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO1_RS20490	COG1414	Transcriptional regulator
APECO1_RS20500	COG2731	YhcH YjgK YiaL family protein
APECO1_RS20510	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APECO1_RS20515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APECO1_RS20520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APECO1_RS20525	COG1070	Carbohydrate kinase
APECO1_RS20530	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APECO1_RS20535	COG3623	hexulose-6-phosphate isomerase
APECO1_RS20540	COG0235	Class ii aldolase
APECO1_RS20545	COG1012	belongs to the aldehyde dehydrogenase family
APECO1_RS20555	COG1454	alcohol dehydrogenase
APECO1_RS20560	COG3276	selenocysteine insertion sequence binding
APECO1_RS20570	COG0625	glutathione transferase activity
APECO1_RS20575	COG1566	PFAM secretion protein HlyD family protein
APECO1_RS20585	COG2213	PTS system mannitol-specific
APECO1_RS20585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS20600	COG3722	fumarate hydratase activity
APECO1_RS20620	COG5295	Hep Hag repeat protein
APECO1_RS20625	COG1620	l-lactate permease
APECO1_RS20630	COG2186	Transcriptional regulator
APECO1_RS20640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APECO1_RS20645	COG1045	serine acetyltransferase
APECO1_RS20660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APECO1_RS20665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APECO1_RS20675	COG4942	peptidase
APECO1_RS20680	COG2861	carbohydrate metabolic process
APECO1_RS20685	COG1216	Glycosyl transferase, family 2
APECO1_RS20695	COG0156	8-amino-7-oxononanoate synthase activity
APECO1_RS20705	COG0859	PFAM glycosyl transferase family 9
APECO1_RS20710	COG0859	PFAM glycosyl transferase family 9
APECO1_RS20715	COG3307	-O-antigen
APECO1_RS20720	COG1216	Glycosyl transferase, family 2
APECO1_RS20725	COG1442	glycosyl transferase family 8
APECO1_RS20730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APECO1_RS20745	COG0515	serine threonine protein kinase
APECO1_RS20750	COG0438	transferase activity, transferring glycosyl groups
APECO1_RS20755	COG0859	PFAM glycosyl transferase family 9
APECO1_RS20760	COG1519	Transferase
APECO1_RS20790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APECO1_RS20815	COG1561	YicC-like family, N-terminal region
APECO1_RS20820	COG3645	SOS response
APECO1_RS20825	COG2860	membrane
APECO1_RS20835	COG0194	GDP metabolic process
APECO1_RS20845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APECO1_RS20850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APECO1_RS20855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APECO1_RS20860	COG0786	glutamate:sodium symporter activity
APECO1_RS20865	COG2233	PERMEase
APECO1_RS20870	COG2982	Protein involved in outer membrane biogenesis
APECO1_RS20880	COG1940	carbohydrate kinase activity
APECO1_RS20895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS20895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS20900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS20905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS20905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS20905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS20910	COG3711	transcriptional antiterminator
APECO1_RS20915	COG1501	Belongs to the glycosyl hydrolase 31 family
APECO1_RS20920	COG2211	Major facilitator Superfamily
APECO1_RS20945	COG0697	spore germination
APECO1_RS20950	COG1464	Belongs to the NlpA lipoprotein family
APECO1_RS20975	COG2252	PERMEase
APECO1_RS20985	COG2271	Major facilitator Superfamily
APECO1_RS20990	COG2271	Major facilitator Superfamily
APECO1_RS20995	COG3851	Histidine kinase
APECO1_RS21000	COG2197	response regulator
APECO1_RS21005	COG0440	acetolactate synthase activity
APECO1_RS21010	COG0028	Belongs to the TPP enzyme family
APECO1_RS21020	COG2814	Major facilitator Superfamily
APECO1_RS21025	COG0641	radical SAM
APECO1_RS21035	COG2149	membrane
APECO1_RS21040	COG3119	arylsulfatase activity
APECO1_RS21045	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APECO1_RS21050	COG2207	Transcriptional regulator
APECO1_RS21075	COG5645	(Lipo)protein
APECO1_RS21080	COG0823	Involved in the tonB-independent uptake of proteins
APECO1_RS21090	COG2271	Major facilitator Superfamily
APECO1_RS21100	COG0800	Aldolase
APECO1_RS21105	COG3734	2-keto-3-deoxy-galactonokinase
APECO1_RS21110	COG2186	Transcriptional regulator
APECO1_RS21120	COG0561	phosphatase activity
APECO1_RS21125	COG3753	Protein conserved in bacteria
APECO1_RS21135	COG0187	DNA topoisomerase II activity
APECO1_RS21145	COG0592	DNA-directed DNA polymerase activity
APECO1_RS21190	COG0814	amino acid
APECO1_RS21200	COG0583	DNA-binding transcription factor activity
APECO1_RS21205	COG2091	lysine biosynthetic process via aminoadipic acid
APECO1_RS21210	COG0431	NADPH-dependent FMN reductase
APECO1_RS21215	COG2252	PERMEase
APECO1_RS21220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APECO1_RS21230	COG0363	glucosamine-6-phosphate deaminase activity
APECO1_RS21235	COG2382	esterase
APECO1_RS21245	COG2723	6-phospho-beta-galactosidase activity
APECO1_RS21250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS21250	COG1263	PTS System
APECO1_RS21250	COG2190	(PTS) system
APECO1_RS21255	COG3711	transcriptional antiterminator
APECO1_RS21260	COG0704	Plays a role in the regulation of phosphate uptake
APECO1_RS21265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APECO1_RS21270	COG0581	inorganic phosphate transmembrane transporter activity
APECO1_RS21275	COG0573	inorganic phosphate transmembrane transporter activity
APECO1_RS21280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APECO1_RS21335	COG3312	ion transport
APECO1_RS21350	COG0716	FMN binding
APECO1_RS21355	COG1522	sequence-specific DNA binding
APECO1_RS21390	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS21395	COG1879	ABC-type sugar transport system periplasmic component
APECO1_RS21400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO1_RS21405	COG1609	Transcriptional regulator
APECO1_RS21410	COG0477	Major facilitator Superfamily
APECO1_RS21415	COG2186	Transcriptional regulator
APECO1_RS21455	COG3085	chromosome segregation
APECO1_RS21460	COG0606	chelatase, subunit chli
APECO1_RS21475	COG3978	acetolactate synthase activity
APECO1_RS21480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APECO1_RS21490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APECO1_RS21495	COG0583	DNA-binding transcription factor activity
APECO1_RS21505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APECO1_RS21510	COG0210	DNA helicase
APECO1_RS21525	COG3118	belongs to the thioredoxin family
APECO1_RS21535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APECO1_RS21545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APECO1_RS21550	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APECO1_RS21555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APECO1_RS21560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APECO1_RS21565	COG1088	dTDP-glucose 4,6-dehydratase activity
APECO1_RS21570	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APECO1_RS21575	COG0456	acetyltransferase
APECO1_RS21580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APECO1_RS21585	COG2244	polysaccharide biosynthetic process
APECO1_RS21605	COG1113	amino acid transport
APECO1_RS21630	COG0641	radical SAM
APECO1_RS21635	COG3119	arylsulfatase activity
APECO1_RS21640	COG3071	HemY protein
APECO1_RS21645	COG2959	enzyme of heme biosynthesis
APECO1_RS21650	COG1587	Uroporphyrinogen-III synthase
APECO1_RS21660	COG3072	Adenylate cyclase
APECO1_RS21680	COG5567	small periplasmic lipoprotein
APECO1_RS21690	COG3159	Protein conserved in bacteria
APECO1_RS21700	COG1011	Hydrolase
APECO1_RS21705	COG0210	DNA helicase
APECO1_RS21710	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
APECO1_RS21715	COG3698	Phosphodiester glycosidase
APECO1_RS21725	COG0598	Magnesium transport protein CorA
APECO1_RS21740	COG2962	Rard protein
APECO1_RS21745	COG2050	protein possibly involved in aromatic compounds catabolism
APECO1_RS21750	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
APECO1_RS21755	COG0514	ATP-dependent DNA helicase (RecQ)
APECO1_RS21760	COG1280	lysine exporter protein (LysE YggA)
APECO1_RS21765	COG1280	lysine exporter protein (LysE YggA)
APECO1_RS21770	COG2267	carboxylic ester hydrolase activity
APECO1_RS21775	COG0561	phosphatase activity
APECO1_RS21780	COG0697	spore germination
APECO1_RS21785	COG0583	DNA-binding transcription factor activity
APECO1_RS21805	COG3157	Type VI secretion system effector, Hcp
APECO1_RS21820	COG2190	(PTS) system
APECO1_RS21820	COG1263	PTS System
APECO1_RS21820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS21825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APECO1_RS21830	COG1737	Transcriptional regulator
APECO1_RS21835	COG0583	DNA-binding transcription factor activity
APECO1_RS21840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APECO1_RS21850	COG0549	Belongs to the carbamate kinase family
APECO1_RS21855	COG1304	FMN binding
APECO1_RS21860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APECO1_RS21870	COG1335	isochorismatase
APECO1_RS21880	COG0412	Dienelactone hydrolase
APECO1_RS21885	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APECO1_RS21905	COG0800	Aldolase
APECO1_RS21910	COG3734	2-keto-3-deoxy-galactonokinase
APECO1_RS21915	COG1414	Transcriptional regulator
APECO1_RS21920	COG1322	Protein conserved in bacteria
APECO1_RS21930	COG3165	ubiquinone biosynthetic process from chorismate
APECO1_RS21940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APECO1_RS21950	COG0805	protein transport
APECO1_RS21965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APECO1_RS21970	COG0543	2 iron, 2 sulfur cluster binding
APECO1_RS21995	COG1739	Uncharacterized protein family UPF0029
APECO1_RS22000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APECO1_RS22005	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
APECO1_RS22035	COG1763	Mo-molybdopterin cofactor biosynthetic process
APECO1_RS22040	COG0746	molybdenum cofactor guanylyltransferase activity
APECO1_RS22045	COG3084	Protein conserved in bacteria
APECO1_RS22050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APECO1_RS22055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APECO1_RS22060	COG5339	Protein conserved in bacteria
APECO1_RS22065	COG0204	Acyl-transferase
APECO1_RS22075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APECO1_RS22075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APECO1_RS22090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APECO1_RS22100	COG2204	response regulator
APECO1_RS22105	COG3852	Histidine kinase
APECO1_RS22110	COG0174	glutamine synthetase
APECO1_RS22120	COG1217	gtp-binding protein TYPA
APECO1_RS22125	COG1349	DNA-binding transcription factor activity
APECO1_RS22130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO1_RS22135	COG2084	Dehydrogenase
APECO1_RS22140	COG3684	Belongs to the aldolase LacD family
APECO1_RS22145	COG1063	alcohol dehydrogenase
APECO1_RS22155	COG0477	Major facilitator Superfamily
APECO1_RS22165	COG1011	Hydrolase
APECO1_RS22180	COG0456	acetyltransferase
APECO1_RS22190	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
APECO1_RS22220	COG2864	formate dehydrogenase
APECO1_RS22225	COG0437	4 iron, 4 sulfur cluster binding
APECO1_RS22230	COG0243	molybdopterin cofactor binding
APECO1_RS22230	COG3383	formate dehydrogenase (NAD+) activity
APECO1_RS22235	COG0243	molybdopterin cofactor binding
APECO1_RS22235	COG3383	formate dehydrogenase (NAD+) activity
APECO1_RS22300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APECO1_RS22315	COG2258	MOSC domain
APECO1_RS22320	COG2205	protein histidine kinase activity
APECO1_RS22325	COG0745	RESPONSE REGULATOR receiver
APECO1_RS22330	COG3678	ATP-independent chaperone mediated protein folding
APECO1_RS22350	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APECO1_RS22370	COG3152	Membrane
APECO1_RS22375	COG3691	Protein conserved in bacteria
APECO1_RS22380	COG0589	response to stress
APECO1_RS22390	COG1494	fructose-1,6-bisphosphatase
APECO1_RS22400	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APECO1_RS22415	COG1575	Belongs to the MenA family. Type 1 subfamily
APECO1_RS22430	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APECO1_RS22435	COG1609	Transcriptional regulator
APECO1_RS22440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APECO1_RS22450	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
APECO1_RS22460	COG0626	cystathionine gamma-synthase activity
APECO1_RS22465	COG0527	aspartate kinase activity
APECO1_RS22465	COG0460	homoserine dehydrogenase
APECO1_RS22475	COG0737	Belongs to the 5'-nucleotidase family
APECO1_RS22480	COG0737	Belongs to the 5'-nucleotidase family
APECO1_RS22490	COG0737	Belongs to the 5'-nucleotidase family
APECO1_RS22495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APECO1_RS22505	COG0697	spore germination
APECO1_RS22510	COG3738	Protein conserved in bacteria
APECO1_RS22520	COG0371	Dehydrogenase
APECO1_RS22525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APECO1_RS22530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS22530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APECO1_RS22530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS22535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS22540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS22545	COG1882	Formate acetyltransferase
APECO1_RS22550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APECO1_RS22555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO1_RS22560	COG2207	Transcriptional regulator
APECO1_RS22565	COG2194	sulfuric ester hydrolase activity
APECO1_RS22580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APECO1_RS22595	COG4948	Mandelate Racemase Muconate Lactonizing
APECO1_RS22600	COG2271	Major facilitator Superfamily
APECO1_RS22605	COG0583	DNA-binding transcription factor activity
APECO1_RS22615	COG1473	amidohydrolase
APECO1_RS22620	COG0477	Major facilitator Superfamily
APECO1_RS22670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APECO1_RS22675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APECO1_RS22675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APECO1_RS22715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APECO1_RS22720	COG0250	Participates in transcription elongation, termination and antitermination
APECO1_RS22755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APECO1_RS22765	COG2104	thiamine diphosphate biosynthetic process
APECO1_RS22770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APECO1_RS22805	COG3068	Protein conserved in bacteria
APECO1_RS22820	COG3678	ATP-independent chaperone mediated protein folding
APECO1_RS22825	COG4191	Histidine kinase
APECO1_RS22830	COG2204	response regulator
APECO1_RS22835	COG0151	Belongs to the GarS family
APECO1_RS22870	COG0456	acetyltransferase
APECO1_RS22880	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APECO1_RS22885	COG2224	Isocitrate lyase
APECO1_RS22895	COG1414	Transcriptional regulator
APECO1_RS22900	COG0646	methionine synthase
APECO1_RS22900	COG1410	methionine synthase
APECO1_RS22915	COG1283	sodium-dependent phosphate transmembrane transporter activity
APECO1_RS22965	COG1187	pseudouridine synthase activity
APECO1_RS22975	COG0527	aspartate kinase activity
APECO1_RS23000	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APECO1_RS23020	COG3833	ABC-type maltose transport systems, permease component
APECO1_RS23025	COG1175	transmembrane transport
APECO1_RS23030	COG2182	Extracellular solute-binding protein
APECO1_RS23040	COG3842	ATPase activity
APECO1_RS23070	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APECO1_RS23080	COG0534	Mate efflux family protein
APECO1_RS23085	COG3237	CsbD-like
APECO1_RS23090	COG0735	belongs to the Fur family
APECO1_RS23095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APECO1_RS23105	COG0604	alcohol dehydrogenase
APECO1_RS23110	COG1053	succinate dehydrogenase
APECO1_RS23115	COG0477	Major facilitator Superfamily
APECO1_RS23120	COG1024	Enoyl-CoA hydratase
APECO1_RS23130	COG1609	Transcriptional regulator
APECO1_RS23135	COG0305	Participates in initiation and elongation during chromosome replication
APECO1_RS23140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APECO1_RS23145	COG3201	nicotinamide mononucleotide transporter
APECO1_RS23155	COG1448	Aminotransferase
APECO1_RS23160	COG0567	Dehydrogenase, E1 component
APECO1_RS23170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APECO1_RS23175	COG0045	succinate-CoA ligase (ADP-forming) activity
APECO1_RS23180	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APECO1_RS23185	COG0471	metal ion transport
APECO1_RS23190	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APECO1_RS23195	COG2204	response regulator
APECO1_RS23205	COG3700	Belongs to the class B bacterial acid phosphatase family
APECO1_RS23210	COG0432	Pfam Uncharacterised protein family UPF0047
APECO1_RS23215	COG2315	Protein conserved in bacteria
APECO1_RS23220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APECO1_RS23225	COG0629	single-stranded DNA binding
APECO1_RS23235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APECO1_RS23240	COG2207	Transcriptional regulator
APECO1_RS23245	COG0789	Transcriptional regulator
APECO1_RS23250	COG2252	PERMEase
APECO1_RS23255	COG0025	NhaP-type Na H and K H
APECO1_RS23260	COG0583	DNA-binding transcription factor activity
APECO1_RS23265	COG1380	Effector of murein hydrolase LrgA
APECO1_RS23270	COG1346	cytolysis
APECO1_RS23280	COG3162	membrane
APECO1_RS23285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APECO1_RS23295	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
APECO1_RS23300	COG0437	4 iron, 4 sulfur cluster binding
APECO1_RS23305	COG3301	Polysulphide reductase, NrfD
APECO1_RS23310	COG1138	Cytochrome C-type biogenesis protein
APECO1_RS23315	COG3088	subunit of a heme lyase
APECO1_RS23320	COG4235	cytochrome complex assembly
APECO1_RS23325	COG1301	dicarboxylic acid transport
APECO1_RS23330	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
APECO1_RS23335	COG4608	Belongs to the ABC transporter superfamily
APECO1_RS23340	COG0444	Belongs to the ABC transporter superfamily
APECO1_RS23345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APECO1_RS23350	COG0601	transmembrane transport
APECO1_RS23360	COG3383	formate dehydrogenase (NAD+) activity
APECO1_RS23365	COG3383	formate dehydrogenase (NAD+) activity
APECO1_RS23375	COG1289	transmembrane transporter activity
APECO1_RS23380	COG1566	PFAM secretion protein HlyD family protein
APECO1_RS23390	COG2015	COG2015, Alkyl sulfatase and related hydrolases
APECO1_RS23395	COG1940	carbohydrate kinase activity
APECO1_RS23400	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APECO1_RS23405	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS23410	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS23415	COG1129	ABC transporter
APECO1_RS23420	COG1879	ABC-type sugar transport system periplasmic component
APECO1_RS23425	COG1737	Transcriptional regulator
APECO1_RS23430	COG0698	ribose 5-phosphate isomerase
APECO1_RS23440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APECO1_RS23445	COG0456	acetyltransferase
APECO1_RS23455	COG3454	Phosphonate metabolism
APECO1_RS23460	COG4778	phosphonate C-P lyase system protein PhnL
APECO1_RS23465	COG4107	phosphonate C-P lyase system protein PhnK
APECO1_RS23470	COG3627	carbon phosphorus lyase activity
APECO1_RS23475	COG3626	phosphonate metabolism
APECO1_RS23480	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
APECO1_RS23485	COG3624	Phosphonate C-P lyase system protein PhnG
APECO1_RS23490	COG2188	Transcriptional regulator
APECO1_RS23495	COG3639	organic phosphonate transmembrane transporter activity
APECO1_RS23500	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
APECO1_RS23510	COG2764	glyoxalase bleomycin resistance protein dioxygenase
APECO1_RS23515	COG2824	Alkylphosphonate utilization operon protein PhnA
APECO1_RS23530	COG0477	Major facilitator Superfamily
APECO1_RS23540	COG0642	Histidine kinase
APECO1_RS23545	COG0745	RESPONSE REGULATOR receiver
APECO1_RS23550	COG2194	sulfuric ester hydrolase activity
APECO1_RS23555	COG0531	amino acid
APECO1_RS23560	COG2207	Transcriptional regulator
APECO1_RS23565	COG1982	Orn Lys Arg decarboxylase major
APECO1_RS23570	COG2169	Transcriptional regulator
APECO1_RS23580	COG1486	melibiose metabolic process
APECO1_RS23585	COG3647	Membrane
APECO1_RS23590	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO1_RS23590	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO1_RS23595	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APECO1_RS23605	COG4565	transcriptional regulatory protein
APECO1_RS23610	COG3290	protein histidine kinase activity
APECO1_RS23615	COG3592	Divergent 4Fe-4S mono-cluster
APECO1_RS23620	COG2388	GCN5-related N-acetyl-transferase
APECO1_RS23635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APECO1_RS23640	COG3104	oligopeptide transport
APECO1_RS23645	COG1982	Orn Lys Arg decarboxylase major
APECO1_RS23650	COG0531	amino acid
APECO1_RS23655	COG3710	Transcriptional regulator
APECO1_RS23695	COG2003	Belongs to the UPF0758 family
APECO1_RS23725	COG2378	regulation of single-species biofilm formation
APECO1_RS23735	COG3596	GTP binding
APECO1_RS23780	COG1309	transcriptional regulator
APECO1_RS23795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APECO1_RS23800	COG2207	Transcriptional regulator
APECO1_RS23805	COG2972	Histidine kinase
APECO1_RS23815	COG3344	reverse transcriptase
APECO1_RS23830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APECO1_RS23835	COG1882	Formate acetyltransferase
APECO1_RS23840	COG0693	protein deglycase activity
APECO1_RS23850	COG1012	belongs to the aldehyde dehydrogenase family
APECO1_RS23885	COG4820	ethanolamine utilization protein (EutJ)
APECO1_RS23890	COG4869	propanediol catabolic process
APECO1_RS23915	COG2831	hemolysin activation secretion protein
APECO1_RS23960	COG4372	Transposase
APECO1_RS23965	COG2801	Transposase and inactivated derivatives
APECO1_RS23975	COG0604	alcohol dehydrogenase
APECO1_RS23995	COG0531	amino acid
APECO1_RS24000	COG1982	Orn Lys Arg decarboxylase major
APECO1_RS24060	COG0582	viral genome integration into host DNA
APECO1_RS24070	COG1309	transcriptional regulator
APECO1_RS24085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APECO1_RS24090	COG1027	Aspartate ammonia-lyase
APECO1_RS24095	COG3030	protein affecting phage T7 exclusion by the F plasmid
APECO1_RS24100	COG0531	amino acid
APECO1_RS24125	COG1509	lysine 2,3-aminomutase activity
APECO1_RS24135	COG5510	response to toxic substance
APECO1_RS24140	COG5510	response to toxic substance
APECO1_RS24145	COG2076	Multidrug Resistance protein
APECO1_RS24150	COG3040	lipid binding
APECO1_RS24155	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
APECO1_RS24170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APECO1_RS24175	COG1053	succinate dehydrogenase
APECO1_RS24185	COG0531	amino acid
APECO1_RS24200	COG1511	domain protein
APECO1_RS24200	COG3264	Mechanosensitive ion channel
APECO1_RS24235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APECO1_RS24240	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APECO1_RS24240	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APECO1_RS24245	COG0802	atpase or kinase
APECO1_RS24250	COG0860	N-Acetylmuramoyl-L-alanine amidase
APECO1_RS24270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APECO1_RS24275	COG0330	HflC and HflK could
APECO1_RS24280	COG0330	HflC and HflK could
APECO1_RS24285	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
APECO1_RS24300	COG0557	exoribonuclease II activity
APECO1_RS24305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APECO1_RS24310	COG3789	protein conserved in bacteria
APECO1_RS24315	COG1842	Phage shock protein A
APECO1_RS24325	COG3766	membrane
APECO1_RS24330	COG5463	Belongs to the UPF0441 family
APECO1_RS24335	COG0754	glutathionylspermidine amidase activity
APECO1_RS24340	COG1960	acyl-CoA dehydrogenase activity
APECO1_RS24350	COG3650	response to hydrogen peroxide
APECO1_RS24355	COG1073	alpha beta
APECO1_RS24370	COG3037	sugar-specific permease SgaT UlaA
APECO1_RS24375	COG3414	Phosphotransferase system galactitol-specific IIB component
APECO1_RS24420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APECO1_RS24440	COG2271	Major facilitator Superfamily
APECO1_RS24445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APECO1_RS24450	COG4670	ketone body catabolic process
APECO1_RS24455	COG1024	Enoyl-CoA hydratase
APECO1_RS24470	COG1309	transcriptional regulator
APECO1_RS24475	COG3061	Opacity-associated protein A
APECO1_RS24480	COG0545	Peptidyl-prolyl cis-trans isomerase
APECO1_RS24485	COG1113	amino acid transport
APECO1_RS24495	COG0697	spore germination
APECO1_RS24500	COG0702	epimerase
APECO1_RS24505	COG1733	regulation of RNA biosynthetic process
APECO1_RS24510	COG0737	Belongs to the 5'-nucleotidase family
APECO1_RS24515	COG1218	3'(2'),5'-bisphosphate nucleotidase
APECO1_RS24520	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APECO1_RS24530	COG1253	flavin adenine dinucleotide binding
APECO1_RS24545	COG0729	surface antigen
APECO1_RS24550	COG2911	Protein conserved in bacteria
APECO1_RS24555	COG2105	PFAM AIG2 family protein
APECO1_RS24560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APECO1_RS24565	COG1879	ABC-type sugar transport system periplasmic component
APECO1_RS24570	COG1129	ABC transporter
APECO1_RS24575	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS24580	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO1_RS24590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APECO1_RS24600	COG0312	modulator of DNA gyrase
APECO1_RS24605	COG3783	Cytochrome b(562)
APECO1_RS24610	COG0602	queuosine metabolic process
APECO1_RS24615	COG1328	CTP reductase activity
APECO1_RS24625	COG0366	Alpha amylase catalytic
APECO1_RS24630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO1_RS24630	COG1263	PTS System
APECO1_RS24635	COG1609	Transcriptional regulator
APECO1_RS24640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APECO1_RS24645	COG0251	oxidation-reduction process
APECO1_RS24665	COG1438	arginine binding
APECO1_RS24675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APECO1_RS24680	COG0549	Belongs to the carbamate kinase family
APECO1_RS24690	COG2731	YhcH YjgK YiaL family protein
APECO1_RS24695	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APECO1_RS24700	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
APECO1_RS24705	COG0456	acetyltransferase
APECO1_RS24715	COG0525	valine-tRNA ligase activity
APECO1_RS24720	COG2927	DNA polymerase III (CHI subunit)
APECO1_RS24730	COG0795	lipopolysaccharide-transporting ATPase activity
APECO1_RS24735	COG0795	lipopolysaccharide-transporting ATPase activity
APECO1_RS24740	COG0433	COG0433 Predicted ATPase
APECO1_RS24745	COG1609	Transcriptional regulator
APECO1_RS24750	COG2610	gluconate transmembrane transporter activity
APECO1_RS24755	COG1028	Short-chain dehydrogenase reductase Sdr
APECO1_RS24760	COG1063	alcohol dehydrogenase
APECO1_RS24765	COG3265	gluconokinase activity
APECO1_RS24770	COG1064	alcohol dehydrogenase
APECO1_RS24805	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APECO1_RS24820	COG0582	viral genome integration into host DNA
APECO1_RS24825	COG4974	Belongs to the 'phage' integrase family
APECO1_RS24840	COG3539	Fimbrial protein
APECO1_RS24845	COG3121	Chaperone
APECO1_RS24850	COG3188	usher protein
APECO1_RS24855	COG3539	Fimbrial protein
APECO1_RS24860	COG3539	Fimbrial protein
APECO1_RS24865	COG3539	Fimbrial protein
APECO1_RS24880	COG0246	Mannitol dehydrogenase
APECO1_RS24890	COG2186	Transcriptional regulator
APECO1_RS24905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO1_RS24905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APECO1_RS24910	COG1461	Dihydroxyacetone kinase
APECO1_RS24915	COG2376	Dihydroxyacetone kinase
APECO1_RS24930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APECO1_RS24945	COG1929	Belongs to the glycerate kinase type-1 family
APECO1_RS24950	COG2084	Dehydrogenase
APECO1_RS24955	COG3622	Belongs to the hyi family
APECO1_RS24960	COG3960	tartronate-semialdehyde synthase activity
APECO1_RS24965	COG3284	Transcriptional regulator
APECO1_RS24975	COG1757	Na H antiporter
APECO1_RS24980	COG0583	DNA-binding transcription factor activity
APECO1_RS24985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APECO1_RS24990	COG0700	Nucleoside recognition
APECO1_RS24995	COG3366	ferrous iron transmembrane transporter activity
APECO1_RS25010	COG0477	Major facilitator Superfamily
APECO1_RS25025	COG1924	4 iron, 4 sulfur cluster binding
APECO1_RS25030	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
APECO1_RS25035	COG2733	membrane
APECO1_RS25055	COG0732	type I restriction modification DNA specificity domain
APECO1_RS25060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APECO1_RS25065	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
APECO1_RS25070	COG1715	Restriction endonuclease
APECO1_RS25075	COG0523	cobalamin synthesis protein
APECO1_RS25080	COG2879	small protein
APECO1_RS25085	COG1966	Carbon starvation protein
APECO1_RS25095	COG0840	transmembrane signaling receptor activity
APECO1_RS25100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APECO1_RS25110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APECO1_RS25115	COG0025	NhaP-type Na H and K H
APECO1_RS25120	COG1802	Transcriptional regulator
APECO1_RS25125	COG1063	alcohol dehydrogenase
APECO1_RS25140	COG1484	DNA-dependent DNA replication
APECO1_RS25155	COG2966	Psort location CytoplasmicMembrane, score
APECO1_RS25160	COG2197	response regulator
APECO1_RS25165	COG2197	response regulator
APECO1_RS25170	COG4114	ferric iron reductase
APECO1_RS25205	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
APECO1_RS25210	COG0456	acetyltransferase
APECO1_RS25215	COG1011	Hydrolase
APECO1_RS25245	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
APECO1_RS25250	COG5532	Uncharacterized conserved protein (DUF2303)
APECO1_RS25275	COG3646	Phage regulatory protein
APECO1_RS25285	COG1846	Transcriptional regulator
APECO1_RS25300	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APECO1_RS25310	COG1403	HNH endonuclease
APECO1_RS25315	COG0484	heat shock protein binding
APECO1_RS25320	COG1278	Cold shock
APECO1_RS25325	COG1278	Cold shock
APECO1_RS25340	COG3772	lysozyme
APECO1_RS25350	COG1278	Cold shock
APECO1_RS25395	COG0740	serine-type endopeptidase activity
APECO1_RS25470	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO1_RS25490	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APECO1_RS25515	COG2823	Periplasmic or secreted lipoprotein
APECO1_RS25525	COG4667	esterase of the alpha-beta hydrolase superfamily
APECO1_RS25530	COG0084	hydrolase, TatD family'
APECO1_RS25535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APECO1_RS25540	COG1328	CTP reductase activity
APECO1_RS25570	COG3550	peptidyl-serine autophosphorylation
APECO1_RS25580	COG3726	membrane protein affecting hemolysin expression
APECO1_RS25585	COG0560	Phosphoserine phosphatase
APECO1_RS25590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APECO1_RS25595	COG3172	ATPase kinase involved in NAD metabolism
APECO1_RS25595	COG1056	cytidyltransferase-related domain
APECO1_RS25600	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
APECO1_RS25610	COG0488	(ABC) transporter
APECO1_RS25615	COG0741	lytic transglycosylase activity
APECO1_RS25635	COG2207	Transcriptional regulator
APECO1_RS25635	COG3708	Transcriptional regulator
APECO1_RS25640	COG3045	CreA protein
APECO1_RS25645	COG0745	RESPONSE REGULATOR receiver
APECO1_RS25650	COG2205	protein histidine kinase activity
APECO1_RS25655	COG4452	Inner membrane protein CreD
APECO1_RS25660	COG0745	RESPONSE REGULATOR receiver
APECO1_RS25670	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
APECO1_RS25755	COG0521	Mo-molybdopterin cofactor biosynthetic process
APECO1_RS25915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APECO1_RS26305	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APECO1_RS26385	COG4104	PAAR repeat-containing protein
APECO1_RS26425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APECO1_RS26475	COG1049	propionate catabolic process, 2-methylcitrate cycle
APECO1_RS26645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APECO1_RS26670	COG0460	homoserine dehydrogenase
APECO1_RS26670	COG0527	aspartate kinase activity
APECO1_RS26685	COG0460	homoserine dehydrogenase
APECO1_RS26685	COG0527	aspartate kinase activity
APECO1_RS26805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APECO1_RS27275	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APECO1_RS27345	COG2132	Multicopper oxidase
APECO1_RS27385	COG0726	polysaccharide deacetylase
APECO1_RS27390	COG0726	polysaccharide deacetylase
APECO1_RS27480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APECO1_RS27500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO1_RS27535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APECO1_RS27895	COG0183	Belongs to the thiolase family
APECO1_RS27905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB