locus-tag	class	description
APECO78_RS00010	COG0746	molybdenum cofactor guanylyltransferase activity
APECO78_RS00015	COG3084	Protein conserved in bacteria
APECO78_RS00020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APECO78_RS00025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APECO78_RS00030	COG5339	Protein conserved in bacteria
APECO78_RS00035	COG0204	Acyl-transferase
APECO78_RS00045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APECO78_RS00045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APECO78_RS00060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APECO78_RS00070	COG2204	response regulator
APECO78_RS00075	COG3852	Histidine kinase
APECO78_RS00085	COG0174	glutamine synthetase
APECO78_RS00095	COG1217	gtp-binding protein TYPA
APECO78_RS00100	COG2188	Transcriptional regulator
APECO78_RS00105	COG1082	Xylose isomerase domain protein TIM barrel
APECO78_RS00110	COG2271	Major facilitator Superfamily
APECO78_RS00115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APECO78_RS00120	COG2211	Major facilitator Superfamily
APECO78_RS00125	COG2211	Major facilitator Superfamily
APECO78_RS00130	COG1501	Belongs to the glycosyl hydrolase 31 family
APECO78_RS00135	COG2017	converts alpha-aldose to the beta-anomer
APECO78_RS00140	COG2942	2-epimerase
APECO78_RS00145	COG3684	Belongs to the aldolase LacD family
APECO78_RS00150	COG2084	Dehydrogenase
APECO78_RS00155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO78_RS00160	COG1349	DNA-binding transcription factor activity
APECO78_RS00165	COG1011	Hydrolase
APECO78_RS00180	COG0456	acetyltransferase
APECO78_RS00185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APECO78_RS00190	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APECO78_RS00205	COG2864	formate dehydrogenase
APECO78_RS00210	COG0437	4 iron, 4 sulfur cluster binding
APECO78_RS00215	COG0243	molybdopterin cofactor binding
APECO78_RS00215	COG3383	formate dehydrogenase (NAD+) activity
APECO78_RS00220	COG0243	molybdopterin cofactor binding
APECO78_RS00220	COG3383	formate dehydrogenase (NAD+) activity
APECO78_RS00235	COG3711	transcriptional antiterminator
APECO78_RS00235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS00240	COG1363	Peptidase, m42
APECO78_RS00245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS00245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS00250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS00295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APECO78_RS00310	COG2258	MOSC domain
APECO78_RS00315	COG2205	protein histidine kinase activity
APECO78_RS00320	COG0745	RESPONSE REGULATOR receiver
APECO78_RS00325	COG3678	ATP-independent chaperone mediated protein folding
APECO78_RS00340	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APECO78_RS00360	COG3152	Membrane
APECO78_RS00365	COG3691	Protein conserved in bacteria
APECO78_RS00370	COG0589	response to stress
APECO78_RS00380	COG1494	fructose-1,6-bisphosphatase
APECO78_RS00390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APECO78_RS00405	COG1575	Belongs to the MenA family. Type 1 subfamily
APECO78_RS00420	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APECO78_RS00425	COG1609	Transcriptional regulator
APECO78_RS00430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APECO78_RS00465	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
APECO78_RS00475	COG0626	cystathionine gamma-synthase activity
APECO78_RS00480	COG0460	homoserine dehydrogenase
APECO78_RS00480	COG0527	aspartate kinase activity
APECO78_RS00490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
APECO78_RS00500	COG0697	spore germination
APECO78_RS00505	COG3738	Protein conserved in bacteria
APECO78_RS00515	COG0371	Dehydrogenase
APECO78_RS00520	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APECO78_RS00525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS00525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APECO78_RS00525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS00530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS00535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS00540	COG1882	Formate acetyltransferase
APECO78_RS00545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APECO78_RS00550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS00555	COG2207	Transcriptional regulator
APECO78_RS00560	COG2194	sulfuric ester hydrolase activity
APECO78_RS00575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APECO78_RS00590	COG4948	Mandelate Racemase Muconate Lactonizing
APECO78_RS00595	COG2271	Major facilitator Superfamily
APECO78_RS00600	COG0583	DNA-binding transcription factor activity
APECO78_RS00660	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
APECO78_RS00660	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
APECO78_RS00700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APECO78_RS00705	COG0250	Participates in transcription elongation, termination and antitermination
APECO78_RS00745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APECO78_RS00755	COG2104	thiamine diphosphate biosynthetic process
APECO78_RS00760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APECO78_RS00795	COG3068	Protein conserved in bacteria
APECO78_RS00810	COG3678	ATP-independent chaperone mediated protein folding
APECO78_RS00815	COG4191	Histidine kinase
APECO78_RS00820	COG2204	response regulator
APECO78_RS00825	COG0151	Belongs to the GarS family
APECO78_RS00865	COG0456	acetyltransferase
APECO78_RS00875	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APECO78_RS00880	COG2224	Isocitrate lyase
APECO78_RS00895	COG1414	Transcriptional regulator
APECO78_RS00900	COG0646	methionine synthase
APECO78_RS00900	COG1410	methionine synthase
APECO78_RS00905	COG1283	sodium-dependent phosphate transmembrane transporter activity
APECO78_RS00970	COG3541	Predicted nucleotidyltransferase
APECO78_RS00975	COG0542	response to heat
APECO78_RS00980	COG0527	aspartate kinase activity
APECO78_RS01005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APECO78_RS01030	COG2814	Major facilitator Superfamily
APECO78_RS01030	COG0477	Major facilitator Superfamily
APECO78_RS01035	COG3833	ABC-type maltose transport systems, permease component
APECO78_RS01040	COG1175	transmembrane transport
APECO78_RS01045	COG2182	Extracellular solute-binding protein
APECO78_RS01055	COG3842	ATPase activity
APECO78_RS01075	COG1357	PFAM Pentapeptide repeats (8 copies)
APECO78_RS01095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APECO78_RS01105	COG0534	Mate efflux family protein
APECO78_RS01110	COG3237	CsbD-like
APECO78_RS01115	COG0735	belongs to the Fur family
APECO78_RS01145	COG5532	Uncharacterized conserved protein (DUF2303)
APECO78_RS01155	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APECO78_RS01160	COG4197	protein conserved in bacteria, prophage-related
APECO78_RS01175	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO78_RS01220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APECO78_RS01230	COG0604	alcohol dehydrogenase
APECO78_RS01235	COG0305	Participates in initiation and elongation during chromosome replication
APECO78_RS01240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APECO78_RS01245	COG1448	Aminotransferase
APECO78_RS01255	COG3700	Belongs to the class B bacterial acid phosphatase family
APECO78_RS01260	COG0432	Pfam Uncharacterised protein family UPF0047
APECO78_RS01265	COG2315	Protein conserved in bacteria
APECO78_RS01270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APECO78_RS01275	COG0629	single-stranded DNA binding
APECO78_RS01285	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APECO78_RS01290	COG2207	Transcriptional regulator
APECO78_RS01295	COG0789	Transcriptional regulator
APECO78_RS01300	COG2252	PERMEase
APECO78_RS01305	COG0025	NhaP-type Na H and K H
APECO78_RS01310	COG1357	PFAM Pentapeptide repeats (8 copies)
APECO78_RS01320	COG3162	membrane
APECO78_RS01325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APECO78_RS01335	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
APECO78_RS01340	COG0437	4 iron, 4 sulfur cluster binding
APECO78_RS01345	COG3301	Polysulphide reductase, NrfD
APECO78_RS01350	COG1138	Cytochrome C-type biogenesis protein
APECO78_RS01355	COG3088	subunit of a heme lyase
APECO78_RS01360	COG4235	cytochrome complex assembly
APECO78_RS01365	COG1301	dicarboxylic acid transport
APECO78_RS01370	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
APECO78_RS01375	COG3383	formate dehydrogenase (NAD+) activity
APECO78_RS01380	COG3383	formate dehydrogenase (NAD+) activity
APECO78_RS01390	COG1289	transmembrane transporter activity
APECO78_RS01395	COG1566	PFAM secretion protein HlyD family protein
APECO78_RS01405	COG2015	COG2015, Alkyl sulfatase and related hydrolases
APECO78_RS01410	COG1940	carbohydrate kinase activity
APECO78_RS01415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APECO78_RS01420	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO78_RS01425	COG1129	ABC transporter
APECO78_RS01430	COG1879	ABC-type sugar transport system periplasmic component
APECO78_RS01435	COG1737	Transcriptional regulator
APECO78_RS01440	COG0698	ribose 5-phosphate isomerase
APECO78_RS01450	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
APECO78_RS01455	COG0456	acetyltransferase
APECO78_RS01460	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
APECO78_RS01465	COG3454	Phosphonate metabolism
APECO78_RS01470	COG4778	phosphonate C-P lyase system protein PhnL
APECO78_RS01475	COG4107	phosphonate C-P lyase system protein PhnK
APECO78_RS01480	COG3627	carbon phosphorus lyase activity
APECO78_RS01485	COG3626	phosphonate metabolism
APECO78_RS01490	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
APECO78_RS01495	COG3624	Phosphonate C-P lyase system protein PhnG
APECO78_RS01500	COG2188	Transcriptional regulator
APECO78_RS01505	COG3639	organic phosphonate transmembrane transporter activity
APECO78_RS01510	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
APECO78_RS01520	COG2764	glyoxalase bleomycin resistance protein dioxygenase
APECO78_RS01525	COG2824	Alkylphosphonate utilization operon protein PhnA
APECO78_RS01540	COG0477	Major facilitator Superfamily
APECO78_RS01550	COG0642	Histidine kinase
APECO78_RS01555	COG0745	RESPONSE REGULATOR receiver
APECO78_RS01560	COG2194	sulfuric ester hydrolase activity
APECO78_RS01565	COG0531	amino acid
APECO78_RS01570	COG2207	Transcriptional regulator
APECO78_RS01575	COG1982	Orn Lys Arg decarboxylase major
APECO78_RS01580	COG2169	Transcriptional regulator
APECO78_RS01590	COG1486	melibiose metabolic process
APECO78_RS01595	COG2211	Major facilitator Superfamily
APECO78_RS01600	COG3647	Membrane
APECO78_RS01605	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO78_RS01605	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO78_RS01610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APECO78_RS01620	COG4565	transcriptional regulatory protein
APECO78_RS01625	COG3290	protein histidine kinase activity
APECO78_RS01630	COG3592	Divergent 4Fe-4S mono-cluster
APECO78_RS01635	COG2388	GCN5-related N-acetyl-transferase
APECO78_RS01650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APECO78_RS01655	COG3104	oligopeptide transport
APECO78_RS01660	COG1982	Orn Lys Arg decarboxylase major
APECO78_RS01665	COG0531	amino acid
APECO78_RS01680	COG1309	transcriptional regulator
APECO78_RS01695	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
APECO78_RS01700	COG1027	Aspartate ammonia-lyase
APECO78_RS01705	COG3030	protein affecting phage T7 exclusion by the F plasmid
APECO78_RS01710	COG0531	amino acid
APECO78_RS01735	COG1509	lysine 2,3-aminomutase activity
APECO78_RS01745	COG5510	response to toxic substance
APECO78_RS01750	COG5510	response to toxic substance
APECO78_RS01755	COG2076	Multidrug Resistance protein
APECO78_RS01760	COG3040	lipid binding
APECO78_RS01765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
APECO78_RS01780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APECO78_RS01785	COG1053	succinate dehydrogenase
APECO78_RS01795	COG0531	amino acid
APECO78_RS01800	COG1511	domain protein
APECO78_RS01800	COG3264	Mechanosensitive ion channel
APECO78_RS01835	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APECO78_RS01840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APECO78_RS01840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APECO78_RS01845	COG0802	atpase or kinase
APECO78_RS01850	COG0860	N-Acetylmuramoyl-L-alanine amidase
APECO78_RS01870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APECO78_RS01875	COG0330	HflC and HflK could
APECO78_RS01880	COG0330	HflC and HflK could
APECO78_RS01885	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
APECO78_RS01900	COG0557	exoribonuclease II activity
APECO78_RS01905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APECO78_RS01910	COG3789	protein conserved in bacteria
APECO78_RS01915	COG1842	Phage shock protein A
APECO78_RS01925	COG3766	membrane
APECO78_RS01930	COG5463	Belongs to the UPF0441 family
APECO78_RS01935	COG0754	glutathionylspermidine amidase activity
APECO78_RS01940	COG1960	acyl-CoA dehydrogenase activity
APECO78_RS01950	COG3650	response to hydrogen peroxide
APECO78_RS01955	COG1073	alpha beta
APECO78_RS01970	COG3037	sugar-specific permease SgaT UlaA
APECO78_RS01975	COG3414	Phosphotransferase system galactitol-specific IIB component
APECO78_RS02020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APECO78_RS02030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APECO78_RS02040	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APECO78_RS02045	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APECO78_RS02050	COG4670	ketone body catabolic process
APECO78_RS02055	COG1024	Enoyl-CoA hydratase
APECO78_RS02070	COG1309	transcriptional regulator
APECO78_RS02075	COG3061	Opacity-associated protein A
APECO78_RS02080	COG0545	Peptidyl-prolyl cis-trans isomerase
APECO78_RS02085	COG1113	amino acid transport
APECO78_RS02105	COG0697	spore germination
APECO78_RS02110	COG0702	epimerase
APECO78_RS02115	COG1733	regulation of RNA biosynthetic process
APECO78_RS02120	COG0737	Belongs to the 5'-nucleotidase family
APECO78_RS02125	COG1218	3'(2'),5'-bisphosphate nucleotidase
APECO78_RS02130	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APECO78_RS02140	COG1253	flavin adenine dinucleotide binding
APECO78_RS02155	COG0729	surface antigen
APECO78_RS02160	COG2911	Protein conserved in bacteria
APECO78_RS02165	COG2105	PFAM AIG2 family protein
APECO78_RS02170	COG2336	PFAM SpoVT AbrB
APECO78_RS02175	COG2337	Toxic component of a toxin-antitoxin (TA) module
APECO78_RS02180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APECO78_RS02185	COG1879	ABC-type sugar transport system periplasmic component
APECO78_RS02190	COG1129	ABC transporter
APECO78_RS02195	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO78_RS02200	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO78_RS02210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APECO78_RS02220	COG0312	modulator of DNA gyrase
APECO78_RS02225	COG3783	Cytochrome b(562)
APECO78_RS02230	COG0602	queuosine metabolic process
APECO78_RS02235	COG1328	CTP reductase activity
APECO78_RS02240	COG0366	Alpha amylase catalytic
APECO78_RS02245	COG1263	PTS System
APECO78_RS02245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO78_RS02250	COG1609	Transcriptional regulator
APECO78_RS02255	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APECO78_RS02260	COG0251	oxidation-reduction process
APECO78_RS02285	COG0251	oxidation-reduction process
APECO78_RS02290	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS02295	COG1309	transcriptional regulator
APECO78_RS02300	COG2731	YhcH YjgK YiaL family protein
APECO78_RS02320	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
APECO78_RS02325	COG0456	acetyltransferase
APECO78_RS02330	COG4269	membrane
APECO78_RS02335	COG0525	valine-tRNA ligase activity
APECO78_RS02340	COG2927	DNA polymerase III (CHI subunit)
APECO78_RS02350	COG0795	lipopolysaccharide-transporting ATPase activity
APECO78_RS02355	COG0795	lipopolysaccharide-transporting ATPase activity
APECO78_RS02360	COG0433	COG0433 Predicted ATPase
APECO78_RS02365	COG1609	Transcriptional regulator
APECO78_RS02370	COG2610	gluconate transmembrane transporter activity
APECO78_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS02380	COG1063	alcohol dehydrogenase
APECO78_RS02385	COG3265	gluconokinase activity
APECO78_RS02390	COG1064	alcohol dehydrogenase
APECO78_RS02400	COG0582	viral genome integration into host DNA
APECO78_RS02405	COG2194	sulfuric ester hydrolase activity
APECO78_RS02430	COG3385	transposase activity
APECO78_RS02435	COG2814	Major facilitator Superfamily
APECO78_RS02440	COG0673	inositol 2-dehydrogenase activity
APECO78_RS02465	COG2085	NADP oxidoreductase coenzyme F420-dependent
APECO78_RS02470	COG1120	ATPase activity
APECO78_RS02475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO78_RS02480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO78_RS02485	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
APECO78_RS02490	COG4772	TonB-dependent receptor
APECO78_RS02495	COG3712	iron ion homeostasis
APECO78_RS02500	COG1595	DNA-templated transcription, initiation
APECO78_RS02545	COG4372	Transposase
APECO78_RS02550	COG3436	PFAM IS66 Orf2 family protein
APECO78_RS02590	COG4584	PFAM Integrase catalytic
APECO78_RS02595	COG1484	DNA-dependent DNA replication
APECO78_RS02620	COG1401	restriction endodeoxyribonuclease activity
APECO78_RS02625	COG1215	transferase activity, transferring glycosyl groups
APECO78_RS02650	COG2390	Transcriptional regulator
APECO78_RS02660	COG2610	gluconate transmembrane transporter activity
APECO78_RS02665	COG0129	dihydroxy-acid dehydratase activity
APECO78_RS02670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APECO78_RS02675	COG1414	Transcriptional regulator
APECO78_RS02680	COG1349	DNA-binding transcription factor activity
APECO78_RS02685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APECO78_RS02690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS02695	COG0434	BtpA family
APECO78_RS02700	COG3775	system Galactitol-specific IIC component
APECO78_RS02705	COG3414	Phosphotransferase system galactitol-specific IIB component
APECO78_RS02710	COG1363	Peptidase, m42
APECO78_RS02720	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
APECO78_RS02725	COG3153	acetyltransferase
APECO78_RS02740	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
APECO78_RS02740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APECO78_RS02750	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
APECO78_RS02755	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APECO78_RS02770	COG0582	viral genome integration into host DNA
APECO78_RS02775	COG4974	Belongs to the 'phage' integrase family
APECO78_RS02785	COG3539	Fimbrial protein
APECO78_RS02790	COG3539	Fimbrial protein
APECO78_RS02795	COG3121	Chaperone
APECO78_RS02800	COG3188	usher protein
APECO78_RS02805	COG3539	Fimbrial protein
APECO78_RS02810	COG3539	Fimbrial protein
APECO78_RS02815	COG3539	Fimbrial protein
APECO78_RS02820	COG2610	gluconate transmembrane transporter activity
APECO78_RS02835	COG0246	Mannitol dehydrogenase
APECO78_RS02845	COG2186	Transcriptional regulator
APECO78_RS02875	COG0583	DNA-binding transcription factor activity
APECO78_RS02880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APECO78_RS02885	COG0700	Nucleoside recognition
APECO78_RS02890	COG3366	ferrous iron transmembrane transporter activity
APECO78_RS02900	COG0477	Major facilitator Superfamily
APECO78_RS02915	COG1924	4 iron, 4 sulfur cluster binding
APECO78_RS02920	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
APECO78_RS02925	COG2733	membrane
APECO78_RS02930	COG2814	Major facilitator Superfamily
APECO78_RS02940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APECO78_RS02945	COG5457	Domain of unknown function (DUF1127)
APECO78_RS02955	COG0523	cobalamin synthesis protein
APECO78_RS02960	COG2879	small protein
APECO78_RS02965	COG1966	Carbon starvation protein
APECO78_RS02975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APECO78_RS02980	COG2368	4-hydroxyphenylacetate
APECO78_RS03000	COG3971	2-oxopent-4-enoate hydratase activity
APECO78_RS03010	COG3384	dioxygenase
APECO78_RS03015	COG1012	belongs to the aldehyde dehydrogenase family
APECO78_RS03020	COG0179	Fumarylacetoacetate (FAA) hydrolase
APECO78_RS03025	COG1846	Transcriptional regulator
APECO78_RS03030	COG0840	transmembrane signaling receptor activity
APECO78_RS03035	COG2271	Major facilitator Superfamily
APECO78_RS03040	COG1802	Transcriptional regulator
APECO78_RS03045	COG1063	alcohol dehydrogenase
APECO78_RS03060	COG1484	DNA-dependent DNA replication
APECO78_RS03075	COG2966	Psort location CytoplasmicMembrane, score
APECO78_RS03080	COG2197	response regulator
APECO78_RS03085	COG2197	response regulator
APECO78_RS03090	COG4114	ferric iron reductase
APECO78_RS03120	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
APECO78_RS03125	COG0456	acetyltransferase
APECO78_RS03130	COG1011	Hydrolase
APECO78_RS03155	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
APECO78_RS03160	COG5532	Uncharacterized conserved protein (DUF2303)
APECO78_RS03175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APECO78_RS03180	COG4197	protein conserved in bacteria, prophage-related
APECO78_RS03200	COG1846	Transcriptional regulator
APECO78_RS03210	COG4725	Belongs to the MT-A70-like family
APECO78_RS03220	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APECO78_RS03230	COG1403	HNH endonuclease
APECO78_RS03235	COG0484	heat shock protein binding
APECO78_RS03250	COG3179	chitinase
APECO78_RS03275	COG1802	Transcriptional regulator
APECO78_RS03275	COG4626	Terminase
APECO78_RS03325	COG4386	tail sheath protein
APECO78_RS03345	COG4228	DNA circulation
APECO78_RS03365	COG3299	homolog of phage Mu protein gp47
APECO78_RS03370	COG3778	Protein conserved in bacteria
APECO78_RS03385	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APECO78_RS03405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APECO78_RS03425	COG2823	Periplasmic or secreted lipoprotein
APECO78_RS03435	COG4667	esterase of the alpha-beta hydrolase superfamily
APECO78_RS03440	COG0084	hydrolase, TatD family'
APECO78_RS03445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APECO78_RS03450	COG1328	CTP reductase activity
APECO78_RS03490	COG3726	membrane protein affecting hemolysin expression
APECO78_RS03495	COG0560	Phosphoserine phosphatase
APECO78_RS03500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APECO78_RS03505	COG1056	cytidyltransferase-related domain
APECO78_RS03505	COG3172	ATPase kinase involved in NAD metabolism
APECO78_RS03515	COG0488	(ABC) transporter
APECO78_RS03520	COG0741	lytic transglycosylase activity
APECO78_RS03540	COG3708	Transcriptional regulator
APECO78_RS03540	COG2207	Transcriptional regulator
APECO78_RS03545	COG3045	CreA protein
APECO78_RS03550	COG0745	RESPONSE REGULATOR receiver
APECO78_RS03555	COG2205	protein histidine kinase activity
APECO78_RS03560	COG4452	Inner membrane protein CreD
APECO78_RS03565	COG0745	RESPONSE REGULATOR receiver
APECO78_RS03575	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
APECO78_RS03585	COG0460	homoserine dehydrogenase
APECO78_RS03585	COG0527	aspartate kinase activity
APECO78_RS03595	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APECO78_RS03615	COG1115	amino acid carrier protein
APECO78_RS03620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APECO78_RS03625	COG0521	Mo-molybdopterin cofactor biosynthetic process
APECO78_RS03630	COG1584	GPR1 FUN34 yaaH family protein
APECO78_RS03635	COG4735	regulation of single-species biofilm formation
APECO78_RS03665	COG0583	DNA-binding transcription factor activity
APECO78_RS03700	COG0196	riboflavin kinase activity
APECO78_RS03715	COG1047	Peptidyl-prolyl cis-trans
APECO78_RS03745	COG0505	Belongs to the CarA family
APECO78_RS03750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APECO78_RS03805	COG0644	oxidoreductase
APECO78_RS03815	COG2271	Major facilitator Superfamily
APECO78_RS03830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APECO78_RS03855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APECO78_RS03860	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
APECO78_RS03865	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
APECO78_RS03870	COG0564	pseudouridine synthase activity
APECO78_RS03880	COG0417	DNA replication proofreading
APECO78_RS03885	COG0235	Class ii aldolase
APECO78_RS03895	COG1069	ribulokinase activity
APECO78_RS03900	COG4977	sequence-specific DNA binding
APECO78_RS03905	COG0586	Pfam SNARE associated Golgi protein
APECO78_RS03915	COG1178	ABC-type Fe3 transport system permease component
APECO78_RS03920	COG4143	(ABC) transporter
APECO78_RS03935	COG2814	Major facilitator Superfamily
APECO78_RS03950	COG0473	3-isopropylmalate dehydrogenase activity
APECO78_RS03965	COG0583	DNA-binding transcription factor activity
APECO78_RS03970	COG0028	Belongs to the TPP enzyme family
APECO78_RS03975	COG0440	acetolactate synthase activity
APECO78_RS03985	COG1609	Transcriptional regulator
APECO78_RS04000	COG3116	cell division
APECO78_RS04005	COG0768	penicillin binding
APECO78_RS04010	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APECO78_RS04015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APECO78_RS04025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APECO78_RS04030	COG0772	Belongs to the SEDS family
APECO78_RS04045	COG1181	Belongs to the D-alanine--D-alanine ligase family
APECO78_RS04050	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APECO78_RS04055	COG0849	cell division
APECO78_RS04060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APECO78_RS04080	COG0494	nUDIX hydrolase
APECO78_RS04100	COG0237	dephospho-CoA kinase activity
APECO78_RS04110	COG1459	type II secretion system
APECO78_RS04115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APECO78_RS04120	COG4969	Belongs to the N-Me-Phe pilin family
APECO78_RS04130	COG0157	Belongs to the NadC ModD family
APECO78_RS04135	COG3023	N-Acetylmuramoyl-L-alanine amidase
APECO78_RS04140	COG3725	Membrane protein required for beta-lactamase induction
APECO78_RS04145	COG1113	amino acid transport
APECO78_RS04150	COG2186	Transcriptional regulator
APECO78_RS04155	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
APECO78_RS04160	COG0508	dehydrogenase complex catalyzes the overall conversion of
APECO78_RS04165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APECO78_RS04170	COG3064	Membrane
APECO78_RS04175	COG1049	propionate catabolic process, 2-methylcitrate cycle
APECO78_RS04200	COG2132	Multicopper oxidase
APECO78_RS04205	COG4993	Dehydrogenase
APECO78_RS04210	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
APECO78_RS04215	COG0288	reversible hydration of carbon dioxide
APECO78_RS04220	COG1131	(ABC) transporter
APECO78_RS04225	COG0842	Transport permease protein
APECO78_RS04230	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS04235	COG0726	polysaccharide deacetylase
APECO78_RS04245	COG5464	transposase or invertase
APECO78_RS04260	COG3539	Fimbrial protein
APECO78_RS04265	COG3539	Fimbrial protein
APECO78_RS04270	COG3539	Fimbrial protein
APECO78_RS04275	COG3539	Fimbrial protein
APECO78_RS04280	COG3188	usher protein
APECO78_RS04285	COG3121	Chaperone
APECO78_RS04290	COG3539	Fimbrial protein
APECO78_RS04295	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APECO78_RS04300	COG0617	tRNA 3'-terminal CCA addition
APECO78_RS04310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APECO78_RS04320	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
APECO78_RS04325	COG1643	Atp-dependent helicase
APECO78_RS04335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
APECO78_RS04340	COG4774	siderophore transport
APECO78_RS04345	COG1120	ATPase activity
APECO78_RS04350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APECO78_RS04355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO78_RS04375	COG2860	membrane
APECO78_RS04380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
APECO78_RS04395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APECO78_RS04400	COG3835	regulator
APECO78_RS04420	COG0024	Methionine aminopeptidase
APECO78_RS04445	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APECO78_RS04450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APECO78_RS04455	COG0575	Belongs to the CDS family
APECO78_RS04460	COG0750	zinc metalloprotease
APECO78_RS04470	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
APECO78_RS04475	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APECO78_RS04500	COG0587	DNA-directed DNA polymerase activity
APECO78_RS04510	COG1982	Orn Lys Arg decarboxylase major
APECO78_RS04515	COG0346	lactoylglutathione lyase activity
APECO78_RS04525	COG4568	rho-dependent transcription termination
APECO78_RS04535	COG4681	YaeQ
APECO78_RS04540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APECO78_RS04545	COG3015	lipoprotein NlpE involved in copper resistance
APECO78_RS04550	COG0791	NLP P60 protein
APECO78_RS04555	COG0791	NLP P60 protein
APECO78_RS04565	COG1720	tRNA m6t6A37 methyltransferase activity
APECO78_RS04575	COG1464	Belongs to the NlpA lipoprotein family
APECO78_RS04580	COG2011	ABC-type metal ion transport system permease component
APECO78_RS04585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
APECO78_RS04590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APECO78_RS04625	COG0656	L-ascorbic acid biosynthetic process
APECO78_RS04630	COG0583	DNA-binding transcription factor activity
APECO78_RS04640	COG2226	methyltransferase
APECO78_RS04645	COG0741	lytic transglycosylase activity
APECO78_RS04645	COG1388	LysM domain
APECO78_RS04655	COG2226	methyltransferase
APECO78_RS04665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APECO78_RS04685	COG4104	PAAR repeat-containing protein
APECO78_RS04690	COG3157	Type VI secretion system effector, Hcp
APECO78_RS04700	COG3209	COG3209 Rhs family protein
APECO78_RS04715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APECO78_RS04725	COG1960	acyl-CoA dehydrogenase activity
APECO78_RS04735	COG0121	glutamine amidotransferase
APECO78_RS04740	COG3034	peptidoglycan biosynthetic process
APECO78_RS04745	COG0791	NLP P60 protein
APECO78_RS04750	COG1943	Transposase
APECO78_RS04765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APECO78_RS04770	COG0454	-acetyltransferase
APECO78_RS04775	COG1690	Belongs to the RtcB family
APECO78_RS04785	COG2195	Cleaves the N-terminal amino acid of tripeptides
APECO78_RS04805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APECO78_RS04825	COG0582	viral genome integration into host DNA
APECO78_RS04840	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
APECO78_RS04845	COG5532	Uncharacterized conserved protein (DUF2303)
APECO78_RS04890	COG1846	Transcriptional regulator
APECO78_RS04900	COG4725	Belongs to the MT-A70-like family
APECO78_RS04910	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APECO78_RS04920	COG1403	HNH endonuclease
APECO78_RS04985	COG1802	Transcriptional regulator
APECO78_RS04985	COG4626	Terminase
APECO78_RS04995	COG4695	Portal protein
APECO78_RS05040	COG4386	tail sheath protein
APECO78_RS05060	COG4228	DNA circulation
APECO78_RS05080	COG3299	homolog of phage Mu protein gp47
APECO78_RS05085	COG3778	Protein conserved in bacteria
APECO78_RS05095	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APECO78_RS05105	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APECO78_RS05120	COG1196	nuclear chromosome segregation
APECO78_RS05130	COG0583	DNA-binding transcription factor activity
APECO78_RS05135	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APECO78_RS05140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APECO78_RS05145	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APECO78_RS05150	COG2080	2 iron, 2 sulfur cluster binding
APECO78_RS05155	COG3477	response to acidic pH
APECO78_RS05160	COG0727	PFAM Uncharacterised protein family (UPF0153)
APECO78_RS05165	COG3121	Chaperone
APECO78_RS05175	COG3188	usher protein
APECO78_RS05215	COG1388	LysM domain
APECO78_RS05220	COG2207	Transcriptional regulator
APECO78_RS05220	COG3708	Transcriptional regulator
APECO78_RS05225	COG3059	membrane
APECO78_RS05235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APECO78_RS05240	COG2207	Transcriptional regulator
APECO78_RS05245	COG0247	lactate metabolic process
APECO78_RS05250	COG1139	Iron-sulfur cluster binding protein
APECO78_RS05255	COG1556	Lactate utilization protein
APECO78_RS05285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APECO78_RS05300	COG0583	DNA-binding transcription factor activity
APECO78_RS05310	COG0666	response to abiotic stimulus
APECO78_RS05320	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APECO78_RS05325	COG1304	FMN binding
APECO78_RS05330	COG0549	Belongs to the carbamate kinase family
APECO78_RS05335	COG0402	S-adenosylhomocysteine deaminase activity
APECO78_RS05340	COG1064	alcohol dehydrogenase
APECO78_RS05355	COG1280	lysine exporter protein (LysE YggA)
APECO78_RS05365	COG3829	transcription factor binding
APECO78_RS05370	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
APECO78_RS05375	COG0372	Belongs to the citrate synthase family
APECO78_RS05380	COG2079	MmgE PrpD family protein
APECO78_RS05385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APECO78_RS05390	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
APECO78_RS05395	COG0402	S-adenosylhomocysteine deaminase activity
APECO78_RS05400	COG0583	DNA-binding transcription factor activity
APECO78_RS05405	COG0288	reversible hydration of carbon dioxide
APECO78_RS05415	COG2807	transmembrane transport
APECO78_RS05420	COG0110	maltose O-acetyltransferase activity
APECO78_RS05425	COG2223	nitrite transmembrane transporter activity
APECO78_RS05435	COG1609	Transcriptional regulator
APECO78_RS05440	COG1414	Transcriptional regulator
APECO78_RS05475	COG2814	Major facilitator Superfamily
APECO78_RS05480	COG3122	Protein conserved in bacteria
APECO78_RS05510	COG1215	transferase activity, transferring glycosyl groups
APECO78_RS05515	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
APECO78_RS05520	COG4521	taurine ABC transporter
APECO78_RS05530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APECO78_RS05535	COG2175	clavaminate synthase activity
APECO78_RS05540	COG0113	porphobilinogen synthase activity
APECO78_RS05560	COG3468	outer membrane autotransporter barrel domain protein
APECO78_RS05565	COG3468	outer membrane autotransporter barrel domain protein
APECO78_RS05570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APECO78_RS05575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
APECO78_RS05585	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
APECO78_RS05610	COG1181	Belongs to the D-alanine--D-alanine ligase family
APECO78_RS05625	COG1785	Belongs to the alkaline phosphatase family
APECO78_RS05635	COG3706	GGDEF domain
APECO78_RS05640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APECO78_RS05665	COG4126	flavin adenine dinucleotide binding
APECO78_RS05685	COG1940	carbohydrate kinase activity
APECO78_RS05690	COG2814	Major facilitator Superfamily
APECO78_RS05695	COG0419	ATPase involved in DNA repair
APECO78_RS05700	COG0420	3'-5' exonuclease activity
APECO78_RS05705	COG0745	RESPONSE REGULATOR receiver
APECO78_RS05710	COG5002	protein histidine kinase activity
APECO78_RS05715	COG1114	Component of the transport system for branched-chain amino acids
APECO78_RS05720	COG1113	amino acid transport
APECO78_RS05725	COG0366	Alpha amylase catalytic
APECO78_RS05745	COG1862	Preprotein translocase
APECO78_RS05750	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APECO78_RS05755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APECO78_RS05760	COG1403	HNH endonuclease
APECO78_RS05770	COG3248	Nucleoside-binding outer membrane protein
APECO78_RS05775	COG4238	major outer membrane lipoprotein
APECO78_RS05785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APECO78_RS05785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APECO78_RS05800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APECO78_RS05805	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
APECO78_RS05810	COG0667	Aldo Keto reductase
APECO78_RS05820	COG0142	geranyltranstransferase activity
APECO78_RS05835	COG0693	protein deglycase activity
APECO78_RS05840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APECO78_RS05850	COG2814	Major facilitator Superfamily
APECO78_RS05860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
APECO78_RS05865	COG1845	cytochrome c oxidase, subunit III
APECO78_RS05870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APECO78_RS05875	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APECO78_RS05880	COG2223	nitrite transmembrane transporter activity
APECO78_RS05885	COG3056	Lipoprotein
APECO78_RS05890	COG0271	Belongs to the BolA IbaG family
APECO78_RS05915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APECO78_RS05920	COG0776	regulation of translation
APECO78_RS05925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APECO78_RS05930	COG1555	photosystem II stabilization
APECO78_RS05935	COG0824	Thioesterase
APECO78_RS05945	COG4533	DNA binding
APECO78_RS05955	COG1522	sequence-specific DNA binding
APECO78_RS05960	COG1132	(ABC) transporter
APECO78_RS05965	COG1132	(ABC) transporter
APECO78_RS05970	COG0347	Belongs to the P(II) protein family
APECO78_RS05975	COG0004	ammonium transporteR
APECO78_RS05980	COG1946	Acyl-CoA thioesterase
APECO78_RS05985	COG3126	Type III secretion system lipoprotein chaperone (YscW)
APECO78_RS05990	COG3695	enzyme binding
APECO78_RS05995	COG5507	3-demethylubiquinone-9 3-methyltransferase
APECO78_RS06000	COG4943	cyclic-guanylate-specific phosphodiesterase activity
APECO78_RS06010	COG0110	maltose O-acetyltransferase activity
APECO78_RS06025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO78_RS06030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO78_RS06035	COG1309	transcriptional regulator
APECO78_RS06040	COG3264	Mechanosensitive ion channel
APECO78_RS06040	COG1196	nuclear chromosome segregation
APECO78_RS06055	COG3923	Primosomal replication protein n
APECO78_RS06060	COG2832	Protein of unknown function (DUF454)
APECO78_RS06070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APECO78_RS06105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO78_RS06110	COG4651	solute:proton antiporter activity
APECO78_RS06110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APECO78_RS06115	COG2223	nitrite transmembrane transporter activity
APECO78_RS06120	COG0737	Belongs to the 5'-nucleotidase family
APECO78_RS06125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APECO78_RS06130	COG3735	TraB family
APECO78_RS06135	COG3093	addiction module antidote protein HigA
APECO78_RS06140	COG2217	Heavy metal translocating P-type atpase
APECO78_RS06145	COG2066	Belongs to the glutaminase family
APECO78_RS06150	COG0531	amino acid
APECO78_RS06155	COG0789	Transcriptional regulator
APECO78_RS06160	COG1585	Membrane protein implicated in regulation of membrane protease activity
APECO78_RS06165	COG0330	HflC and HflK could
APECO78_RS06170	COG4619	ABC transporter
APECO78_RS06175	COG0390	transport system, permease component
APECO78_RS06180	COG3118	belongs to the thioredoxin family
APECO78_RS06185	COG0300	oxidoreductase activity
APECO78_RS06190	COG2755	lipolytic protein G-D-S-L family
APECO78_RS06195	COG4181	ATPase activity
APECO78_RS06200	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
APECO78_RS06210	COG0583	DNA-binding transcription factor activity
APECO78_RS06220	COG1414	Transcriptional regulator
APECO78_RS06225	COG3960	tartronate-semialdehyde synthase activity
APECO78_RS06230	COG3622	Belongs to the hyi family
APECO78_RS06235	COG2084	Dehydrogenase
APECO78_RS06250	COG2233	PERMEase
APECO78_RS06255	COG1929	Belongs to the glycerate kinase type-1 family
APECO78_RS06260	COG3257	ureidoglycine aminohydrolase activity
APECO78_RS06265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APECO78_RS06270	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APECO78_RS06275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APECO78_RS06280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APECO78_RS06290	COG0549	Belongs to the carbamate kinase family
APECO78_RS06295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APECO78_RS06300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APECO78_RS06310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APECO78_RS06320	COG1988	membrane-bound metal-dependent
APECO78_RS06325	COG2501	S4 domain
APECO78_RS06335	COG3539	Fimbrial protein
APECO78_RS06340	COG3121	Chaperone
APECO78_RS06345	COG3188	usher protein
APECO78_RS06350	COG3539	Fimbrial protein
APECO78_RS06355	COG3539	Fimbrial protein
APECO78_RS06360	COG2197	response regulator
APECO78_RS06370	COG0582	viral genome integration into host DNA
APECO78_RS06385	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
APECO78_RS06390	COG5532	Uncharacterized conserved protein (DUF2303)
APECO78_RS06400	COG4220	transposase activity
APECO78_RS06435	COG3772	lysozyme
APECO78_RS06480	COG1403	HNH endonuclease
APECO78_RS06490	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
APECO78_RS06500	COG4725	Belongs to the MT-A70-like family
APECO78_RS06510	COG1846	Transcriptional regulator
APECO78_RS06520	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO78_RS06525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APECO78_RS06535	COG0500	methyltransferase
APECO78_RS06550	COG4571	Outer membrane protease
APECO78_RS06560	COG2207	Transcriptional regulator
APECO78_RS06575	COG4783	chaperone-mediated protein folding
APECO78_RS06580	COG1215	transferase activity, transferring glycosyl groups
APECO78_RS06585	COG5433	transposase activity
APECO78_RS06600	COG4104	PAAR repeat-containing protein
APECO78_RS06600	COG3209	COG3209 Rhs family protein
APECO78_RS06605	COG4104	PAAR repeat-containing protein
APECO78_RS06605	COG3209	COG3209 Rhs family protein
APECO78_RS06615	COG3501	Rhs element vgr protein
APECO78_RS06620	COG5002	protein histidine kinase activity
APECO78_RS06625	COG0745	RESPONSE REGULATOR receiver
APECO78_RS06630	COG1538	Outer membrane efflux protein
APECO78_RS06635	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO78_RS06640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO78_RS06645	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO78_RS06650	COG1113	amino acid transport
APECO78_RS06655	COG0668	transmembrane transport
APECO78_RS06660	COG0778	Nitroreductase
APECO78_RS06665	COG2315	Protein conserved in bacteria
APECO78_RS06690	COG2977	Belongs to the P-Pant transferase superfamily
APECO78_RS06695	COG4771	TonB-dependent receptor
APECO78_RS06700	COG2382	esterase
APECO78_RS06705	COG3251	PFAM MbtH domain protein
APECO78_RS06710	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
APECO78_RS06710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
APECO78_RS06715	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APECO78_RS06720	COG1120	ATPase activity
APECO78_RS06725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO78_RS06730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
APECO78_RS06740	COG4592	Periplasmic binding protein
APECO78_RS06745	COG1169	isochorismate synthase
APECO78_RS06750	COG1021	2,3-dihydroxybenzoate-AMP ligase
APECO78_RS06755	COG3433	isochorismatase activity
APECO78_RS06755	COG1535	isochorismatase
APECO78_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS06765	COG2050	protein possibly involved in aromatic compounds catabolism
APECO78_RS06770	COG1966	Carbon starvation protein
APECO78_RS06775	COG2879	small protein
APECO78_RS06780	COG0371	Dehydrogenase
APECO78_RS06785	COG0436	Aminotransferase
APECO78_RS06790	COG1475	DNA binding
APECO78_RS06795	COG3969	phosphoadenosine phosphosulfate
APECO78_RS06800	COG0583	DNA-binding transcription factor activity
APECO78_RS06805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APECO78_RS06810	COG0450	alkyl hydroperoxide reductase
APECO78_RS06815	COG3634	alkyl hydroperoxide reductase activity
APECO78_RS06820	COG0589	response to stress
APECO78_RS06825	COG1063	alcohol dehydrogenase
APECO78_RS06835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APECO78_RS06840	COG3719	Belongs to the RNase T2 family
APECO78_RS06845	COG0471	metal ion transport
APECO78_RS06860	COG3051	citrate lyase alpha subunit
APECO78_RS06865	COG2301	Belongs to the HpcH HpaI aldolase family
APECO78_RS06875	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
APECO78_RS06880	COG3290	protein histidine kinase activity
APECO78_RS06885	COG4565	transcriptional regulatory protein
APECO78_RS06890	COG3069	C4-dicarboxylate transmembrane transporter activity
APECO78_RS06910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APECO78_RS06915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APECO78_RS06925	COG0583	DNA-binding transcription factor activity
APECO78_RS06945	COG1686	Belongs to the peptidase S11 family
APECO78_RS06950	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APECO78_RS06955	COG0772	Belongs to the SEDS family
APECO78_RS06960	COG0768	penicillin binding
APECO78_RS06970	COG0799	negative regulation of ribosome biogenesis
APECO78_RS06975	COG0406	alpha-ribazole phosphatase activity
APECO78_RS06985	COG1466	dna polymerase III delta subunit
APECO78_RS07000	COG2888	peptidyl-tyrosine sulfation
APECO78_RS07005	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
APECO78_RS07015	COG2214	Heat shock protein DnaJ domain protein
APECO78_RS07020	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
APECO78_RS07045	COG1126	abc transporter atp-binding protein
APECO78_RS07050	COG0765	amino acid transport
APECO78_RS07055	COG0765	amino acid transport
APECO78_RS07060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO78_RS07070	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APECO78_RS07075	COG4535	Mg2 and Co2 transporter CorC
APECO78_RS07085	COG1702	phosphate starvation-inducible protein PhoH
APECO78_RS07095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APECO78_RS07135	COG0367	asparagine synthase
APECO78_RS07145	COG0647	UMP catabolic process
APECO78_RS07150	COG1940	carbohydrate kinase activity
APECO78_RS07150	COG1846	Transcriptional regulator
APECO78_RS07155	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APECO78_RS07165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO78_RS07165	COG1263	PTS System
APECO78_RS07165	COG2190	(PTS) system
APECO78_RS07185	COG0735	belongs to the Fur family
APECO78_RS07200	COG0716	FMN binding
APECO78_RS07210	COG0596	Alpha beta hydrolase
APECO78_RS07215	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
APECO78_RS07220	COG0033	Phosphoglucomutase
APECO78_RS07225	COG0531	amino acid
APECO78_RS07230	COG1982	Orn Lys Arg decarboxylase major
APECO78_RS07240	COG0745	RESPONSE REGULATOR receiver
APECO78_RS07245	COG2205	protein histidine kinase activity
APECO78_RS07275	COG3209	COG3209 Rhs family protein
APECO78_RS07285	COG3209	COG3209 Rhs family protein
APECO78_RS07295	COG5433	transposase activity
APECO78_RS07305	COG3272	Protein of unknown function (DUF1722)
APECO78_RS07310	COG0415	Belongs to the DNA photolyase family
APECO78_RS07320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
APECO78_RS07325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
APECO78_RS07330	COG1984	allophanate hydrolase subunit 2
APECO78_RS07345	COG3180	Ammonia monooxygenase
APECO78_RS07350	COG3539	Fimbrial protein
APECO78_RS07355	COG3121	Chaperone
APECO78_RS07360	COG3188	usher protein
APECO78_RS07365	COG3539	Fimbrial protein
APECO78_RS07370	COG0372	Belongs to the citrate synthase family
APECO78_RS07380	COG2009	succinate dehydrogenase
APECO78_RS07385	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
APECO78_RS07390	COG1053	succinate dehydrogenase
APECO78_RS07395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APECO78_RS07405	COG0567	Dehydrogenase, E1 component
APECO78_RS07410	COG0508	dehydrogenase complex catalyzes the overall conversion of
APECO78_RS07420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APECO78_RS07425	COG2188	Transcriptional regulator
APECO78_RS07430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS07430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS07430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS07435	COG0383	alpha-mannosidase activity
APECO78_RS07445	COG1271	oxidase subunit
APECO78_RS07450	COG1294	oxidase, subunit
APECO78_RS07455	COG4890	Cyd operon protein YbgT
APECO78_RS07460	COG3790	cyd operon protein YbgE
APECO78_RS07465	COG0824	Thioesterase
APECO78_RS07470	COG0811	peptide transport
APECO78_RS07475	COG0848	biopolymer transport protein
APECO78_RS07480	COG3064	Membrane
APECO78_RS07490	COG2885	chlorophyll binding
APECO78_RS07495	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
APECO78_RS07540	COG3201	nicotinamide mononucleotide transporter
APECO78_RS07545	COG1230	cation diffusion facilitator family transporter
APECO78_RS07560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APECO78_RS07570	COG2017	converts alpha-aldose to the beta-anomer
APECO78_RS07580	COG1085	galactose-1-phosphate uridylyltransferase
APECO78_RS07585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APECO78_RS07590	COG1119	ATPase activity
APECO78_RS07600	COG2005	Transcriptional regulator
APECO78_RS07600	COG3585	molybdate ion transport
APECO78_RS07610	COG0725	ABC transporter, periplasmic molybdate-binding protein
APECO78_RS07615	COG4149	molybdate abc transporter
APECO78_RS07620	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
APECO78_RS07625	COG0561	phosphatase activity
APECO78_RS07635	COG0583	DNA-binding transcription factor activity
APECO78_RS07640	COG2828	Protein conserved in bacteria
APECO78_RS07645	COG0471	metal ion transport
APECO78_RS07650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APECO78_RS07655	COG4677	pectinesterase activity
APECO78_RS07660	COG0582	viral genome integration into host DNA
APECO78_RS07770	COG3772	lysozyme
APECO78_RS07785	COG5562	phage envelope protein
APECO78_RS07810	COG4220	transposase activity
APECO78_RS07830	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO78_RS07835	COG2207	Transcriptional regulator
APECO78_RS07845	COG2963	transposase activity
APECO78_RS07850	COG1881	PFAM PEBP family protein
APECO78_RS07855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
APECO78_RS07870	COG2226	methyltransferase
APECO78_RS07875	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APECO78_RS07885	COG0391	Required for morphogenesis under gluconeogenic growth conditions
APECO78_RS07900	COG0521	Mo-molybdopterin cofactor biosynthetic process
APECO78_RS07910	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APECO78_RS07915	COG0314	molybdopterin synthase activity
APECO78_RS07920	COG0670	Belongs to the BI1 family
APECO78_RS07925	COG0670	Belongs to the BI1 family
APECO78_RS07930	COG0392	lysyltransferase activity
APECO78_RS07935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APECO78_RS07940	COG3568	Endonuclease Exonuclease Phosphatase
APECO78_RS07950	COG0842	Transport permease protein
APECO78_RS07955	COG0842	Transport permease protein
APECO78_RS07960	COG1131	(ABC) transporter
APECO78_RS07970	COG1309	transcriptional regulator
APECO78_RS07975	COG0513	Belongs to the DEAD box helicase family
APECO78_RS07980	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
APECO78_RS07985	COG1199	ATP-dependent helicase activity
APECO78_RS07990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APECO78_RS07995	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
APECO78_RS08005	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APECO78_RS08015	COG4774	siderophore transport
APECO78_RS08030	COG0668	transmembrane transport
APECO78_RS08035	COG1126	abc transporter atp-binding protein
APECO78_RS08040	COG0765	amino acid transport
APECO78_RS08045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO78_RS08060	COG5006	permease, DMT superfamily
APECO78_RS08065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
APECO78_RS08070	COG2194	sulfuric ester hydrolase activity
APECO78_RS08080	COG1321	iron dependent repressor
APECO78_RS08085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APECO78_RS08090	COG1376	ErfK ybiS ycfS ynhG family protein
APECO78_RS08095	COG0488	(ABC) transporter
APECO78_RS08105	COG0561	phosphatase activity
APECO78_RS08110	COG1882	Formate acetyltransferase
APECO78_RS08115	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APECO78_RS08120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APECO78_RS08125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
APECO78_RS08130	COG0303	'Molybdopterin
APECO78_RS08135	COG1446	asparaginase
APECO78_RS08160	COG2200	EAL domain
APECO78_RS08165	COG2199	diguanylate cyclase activity
APECO78_RS08180	COG2133	pyrroloquinoline quinone binding
APECO78_RS08185	COG0625	glutathione transferase activity
APECO78_RS08190	COG1686	Belongs to the peptidase S11 family
APECO78_RS08195	COG1349	DNA-binding transcription factor activity
APECO78_RS08200	COG0671	phosphoesterase, PA-phosphatase related
APECO78_RS08205	COG2814	Major facilitator Superfamily
APECO78_RS08215	COG0561	phosphatase activity
APECO78_RS08220	COG0738	Major facilitator superfamily
APECO78_RS08225	COG3226	Transcriptional regulator
APECO78_RS08230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
APECO78_RS08260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
APECO78_RS08300	COG4695	Portal protein
APECO78_RS08335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APECO78_RS08345	COG0778	Nitroreductase
APECO78_RS08365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APECO78_RS08370	COG3842	ATPase activity
APECO78_RS08375	COG1176	ABC-type spermidine putrescine transport system, permease component I
APECO78_RS08380	COG1177	transmembrane transport
APECO78_RS08395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO78_RS08400	COG4160	amino acid transport
APECO78_RS08405	COG4215	(ABC) transporter
APECO78_RS08410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO78_RS08415	COG1126	abc transporter atp-binding protein
APECO78_RS08430	COG3023	N-Acetylmuramoyl-L-alanine amidase
APECO78_RS08435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APECO78_RS08440	COG0702	epimerase
APECO78_RS08445	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
APECO78_RS08450	COG0028	Belongs to the TPP enzyme family
APECO78_RS08455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APECO78_RS08465	COG2431	L-lysine efflux transmembrane transporter activity
APECO78_RS08480	COG3593	DNA synthesis involved in DNA repair
APECO78_RS08485	COG2990	Protein conserved in bacteria
APECO78_RS08490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO78_RS08495	COG0577	efflux transmembrane transporter activity
APECO78_RS08495	COG1136	(ABC) transporter
APECO78_RS08500	COG1278	Cold shock
APECO78_RS08510	COG0542	response to heat
APECO78_RS08530	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
APECO78_RS08535	COG4988	ABC transporter
APECO78_RS08540	COG0492	ferredoxin-NADP+ reductase activity
APECO78_RS08545	COG1522	sequence-specific DNA binding
APECO78_RS08560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
APECO78_RS08570	COG0243	molybdopterin cofactor binding
APECO78_RS08575	COG0437	4 iron, 4 sulfur cluster binding
APECO78_RS08580	COG3302	dmso reductase anchor subunit
APECO78_RS08585	COG1335	isochorismatase
APECO78_RS08595	COG0531	amino acid
APECO78_RS08600	COG0583	DNA-binding transcription factor activity
APECO78_RS08605	COG2249	NAD(P)H dehydrogenase (quinone) activity
APECO78_RS08610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APECO78_RS08615	COG4974	Belongs to the 'phage' integrase family
APECO78_RS08690	COG4695	Portal protein
APECO78_RS08765	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO78_RS08765	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO78_RS08830	COG1882	Formate acetyltransferase
APECO78_RS08835	COG2116	formate transmembrane transporter activity
APECO78_RS08840	COG1944	ATP diphosphatase activity
APECO78_RS08845	COG2323	membrane
APECO78_RS08860	COG0501	Belongs to the peptidase M48B family
APECO78_RS08870	COG0539	negative regulation of cytoplasmic translation
APECO78_RS08880	COG0658	competence protein
APECO78_RS08880	COG2333	competence protein COMEC
APECO78_RS08885	COG1132	(ABC) transporter
APECO78_RS08895	COG3214	Protein conserved in bacteria
APECO78_RS08910	COG3173	Aminoglycoside phosphotransferase
APECO78_RS08915	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APECO78_RS08920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APECO78_RS08930	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
APECO78_RS08940	COG2989	Protein conserved in bacteria
APECO78_RS08945	COG3108	Peptidase M15
APECO78_RS08950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APECO78_RS08955	COG1448	Aminotransferase
APECO78_RS08980	COG0308	aminopeptidase N
APECO78_RS08990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APECO78_RS09000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APECO78_RS09005	COG0431	NADPH-dependent FMN reductase
APECO78_RS09010	COG3539	Fimbrial protein
APECO78_RS09015	COG3121	Chaperone
APECO78_RS09020	COG3188	usher protein
APECO78_RS09025	COG3539	Fimbrial protein
APECO78_RS09030	COG3539	Fimbrial protein
APECO78_RS09035	COG3539	Fimbrial protein
APECO78_RS09040	COG3121	Chaperone
APECO78_RS09055	COG0633	Ferredoxin
APECO78_RS09055	COG3217	Mosc domain protein beta barrel domain protein
APECO78_RS09065	COG0488	(ABC) transporter
APECO78_RS09070	COG2995	paraquat-inducible protein a
APECO78_RS09075	COG3008	intermembrane lipid transfer
APECO78_RS09075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APECO78_RS09080	COG3009	Protein conserved in bacteria
APECO78_RS09085	COG3130	regulation of translation
APECO78_RS09095	COG1067	ATP-dependent peptidase activity
APECO78_RS09120	COG3070	regulator of competence-specific genes
APECO78_RS09125	COG1289	transmembrane transporter activity
APECO78_RS09130	COG3304	Inner membrane component domain
APECO78_RS09135	COG0210	DNA helicase
APECO78_RS09155	COG1832	CoA-binding protein
APECO78_RS09170	COG1254	Belongs to the acylphosphatase family
APECO78_RS09175	COG2920	part of a sulfur-relay system
APECO78_RS09180	COG0670	Belongs to the BI1 family
APECO78_RS09190	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APECO78_RS09195	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APECO78_RS09200	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
APECO78_RS09205	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APECO78_RS09210	COG1999	signal sequence binding
APECO78_RS09215	COG1773	rubredoxin
APECO78_RS09220	COG1271	oxidase subunit
APECO78_RS09225	COG1294	oxidase, subunit
APECO78_RS09240	COG3206	protein involved in exopolysaccharide biosynthesis
APECO78_RS09240	COG0489	protein tyrosine kinase activity
APECO78_RS09245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APECO78_RS09250	COG1596	polysaccharide export
APECO78_RS09255	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APECO78_RS09275	COG1278	Cold shock
APECO78_RS09280	COG1278	Cold shock
APECO78_RS09295	COG0348	domain, Protein
APECO78_RS09300	COG0784	Response regulator, receiver
APECO78_RS09300	COG2198	Histidine kinase
APECO78_RS09300	COG2205	protein histidine kinase activity
APECO78_RS09305	COG1879	ABC-type sugar transport system periplasmic component
APECO78_RS09310	COG0745	RESPONSE REGULATOR receiver
APECO78_RS09315	COG3005	denitrification pathway
APECO78_RS09320	COG0243	molybdopterin cofactor binding
APECO78_RS09365	COG3729	General stress protein
APECO78_RS09370	COG2233	PERMEase
APECO78_RS09405	COG1309	transcriptional regulator
APECO78_RS09410	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APECO78_RS09410	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APECO78_RS09410	COG0506	proline dehydrogenase activity
APECO78_RS09420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APECO78_RS09435	COG2822	iron ion transport
APECO78_RS09450	COG1702	phosphate starvation-inducible protein PhoH
APECO78_RS09455	COG3658	cytochrome
APECO78_RS09460	COG1215	transferase activity, transferring glycosyl groups
APECO78_RS09465	COG1649	PFAM Uncharacterised BCR, COG1649
APECO78_RS09465	COG0726	polysaccharide deacetylase
APECO78_RS09470	COG0457	Tetratricopeptide repeat
APECO78_RS09475	COG3706	GGDEF domain
APECO78_RS09480	COG2801	Transposase and inactivated derivatives
APECO78_RS09520	COG3381	protein complex oligomerization
APECO78_RS09530	COG1462	curli production assembly transport component CsgG
APECO78_RS09545	COG2197	response regulator
APECO78_RS09575	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APECO78_RS09580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APECO78_RS09605	COG2943	transferase activity, transferring hexosyl groups
APECO78_RS09610	COG5645	(Lipo)protein
APECO78_RS09630	COG1560	Kdo2-lipid A biosynthetic process
APECO78_RS09640	COG2353	YceI-like domain
APECO78_RS09645	COG3038	cytochrome b561
APECO78_RS09680	COG2999	glutathione oxidoreductase activity
APECO78_RS09690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APECO78_RS09700	COG0673	inositol 2-dehydrogenase activity
APECO78_RS09705	COG0728	peptidoglycan biosynthetic process
APECO78_RS09710	COG3418	PFAM FlgN family protein
APECO78_RS09715	COG2747	anti-sigma28 factor FlgM
APECO78_RS09720	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
APECO78_RS09725	COG1815	bacterial-type flagellum-dependent cell motility
APECO78_RS09730	COG1558	bacterial-type flagellum-dependent cell motility
APECO78_RS09735	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
APECO78_RS09740	COG1749	Flagellar hook protein flgE
APECO78_RS09745	COG4787	bacterial-type flagellum-dependent cell motility
APECO78_RS09750	COG4786	Flagellar basal body rod
APECO78_RS09765	COG1705	Flagellar rod assembly protein muramidase FlgJ
APECO78_RS09765	COG3951	Flagellar rod assembly protein muramidase FlgJ
APECO78_RS09770	COG1256	bacterial-type flagellum assembly
APECO78_RS09775	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
APECO78_RS09780	COG1530	ribonuclease E activity
APECO78_RS09790	COG0564	pseudouridine synthase activity
APECO78_RS09795	COG0424	maF-like protein
APECO78_RS09800	COG1399	metal-binding, possibly nucleic acid-binding protein
APECO78_RS09820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APECO78_RS09825	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS09835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APECO78_RS09840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APECO78_RS09845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APECO78_RS09855	COG0470	DNA polymerase III
APECO78_RS09860	COG0084	hydrolase, TatD family'
APECO78_RS09865	COG1263	PTS System
APECO78_RS09865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO78_RS09870	COG4773	Receptor
APECO78_RS09875	COG0537	adenosine 5'-monophosphoramidase activity
APECO78_RS09880	COG5633	Lipoprotein
APECO78_RS09885	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
APECO78_RS09905	COG1252	NADH dehydrogenase
APECO78_RS09910	COG3134	Outer membrane lipoprotein
APECO78_RS09915	COG1309	transcriptional regulator
APECO78_RS09925	COG1388	LysM domain
APECO78_RS09925	COG1376	ErfK ybiS ycfS ynhG family protein
APECO78_RS09930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APECO78_RS09935	COG4763	Acyl-transferase
APECO78_RS09940	COG4591	ABC-type transport system involved in lipoprotein release permease component
APECO78_RS09950	COG4591	ABC-type transport system involved in lipoprotein release permease component
APECO78_RS09960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
APECO78_RS09965	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APECO78_RS09975	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
APECO78_RS09980	COG1177	transmembrane transport
APECO78_RS10005	COG2850	peptidyl-arginine hydroxylation
APECO78_RS10010	COG2205	protein histidine kinase activity
APECO78_RS10015	COG0745	RESPONSE REGULATOR receiver
APECO78_RS10020	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APECO78_RS10040	COG1187	pseudouridine synthase activity
APECO78_RS10045	COG0538	isocitrate dehydrogenase activity
APECO78_RS10060	COG5562	phage envelope protein
APECO78_RS10065	COG0789	Transcriptional regulator
APECO78_RS10070	COG2200	EAL domain
APECO78_RS10095	COG2200	EAL domain
APECO78_RS10145	COG2894	cell division
APECO78_RS10185	COG0179	Fumarylacetoacetate (FAA) hydrolase
APECO78_RS10205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
APECO78_RS10210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
APECO78_RS10230	COG2719	SpoVR family
APECO78_RS10240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APECO78_RS10250	COG1619	proteins homologs of microcin C7 resistance protein MccF
APECO78_RS10260	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
APECO78_RS10280	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
APECO78_RS10280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS10280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APECO78_RS10285	COG1461	Dihydroxyacetone kinase
APECO78_RS10290	COG2376	Dihydroxyacetone kinase
APECO78_RS10295	COG3284	Transcriptional regulator
APECO78_RS10310	COG0012	GTP binding
APECO78_RS10325	COG0659	secondary active sulfate transmembrane transporter activity
APECO78_RS10330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APECO78_RS10360	COG3094	Invasion gene expression up-regulator, SirB
APECO78_RS10365	COG2912	Transglutaminase-like superfamily
APECO78_RS10385	COG0387	Pfam Sodium calcium exchanger
APECO78_RS10390	COG4572	Cation transport regulator
APECO78_RS10395	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
APECO78_RS10400	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
APECO78_RS10405	COG4932	domain protein
APECO78_RS10410	COG2197	response regulator
APECO78_RS10415	COG3850	Histidine kinase
APECO78_RS10425	COG2223	nitrite transmembrane transporter activity
APECO78_RS10430	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APECO78_RS10435	COG1140	nitrate reductase beta subunit
APECO78_RS10440	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APECO78_RS10445	COG2181	nitrate reductase activity
APECO78_RS10460	COG0788	formyltetrahydrofolate deformylase activity
APECO78_RS10470	COG1752	Esterase of the alpha-beta hydrolase superfamily
APECO78_RS10475	COG0745	RESPONSE REGULATOR receiver
APECO78_RS10480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APECO78_RS10495	COG1454	alcohol dehydrogenase
APECO78_RS10495	COG1012	belongs to the aldehyde dehydrogenase family
APECO78_RS10500	COG2095	MarC family integral membrane protein
APECO78_RS10505	COG4166	transmembrane transport
APECO78_RS10510	COG0601	transmembrane transport
APECO78_RS10515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APECO78_RS10520	COG0444	Belongs to the ABC transporter superfamily
APECO78_RS10525	COG4608	Belongs to the ABC transporter superfamily
APECO78_RS10545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APECO78_RS10550	COG2350	Protein conserved in bacteria
APECO78_RS10555	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
APECO78_RS10560	COG1607	acyl-coa hydrolase
APECO78_RS10575	COG3047	cAMP biosynthetic process
APECO78_RS10580	COG3685	Protein conserved in bacteria
APECO78_RS10585	COG3685	Protein conserved in bacteria
APECO78_RS10590	COG3729	General stress protein
APECO78_RS10605	COG0134	indole-3-glycerol-phosphate synthase activity
APECO78_RS10605	COG0135	phosphoribosylanthranilate isomerase activity
APECO78_RS10610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APECO78_RS10610	COG0512	Glutamine amidotransferase of anthranilate synthase
APECO78_RS10615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APECO78_RS10620	COG0613	PHP domain protein
APECO78_RS10625	COG0009	L-threonylcarbamoyladenylate synthase
APECO78_RS10630	COG1187	pseudouridine synthase activity
APECO78_RS10635	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
APECO78_RS10640	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS10650	COG0616	signal peptide processing
APECO78_RS10665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APECO78_RS10670	COG0583	DNA-binding transcription factor activity
APECO78_RS10695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
APECO78_RS10705	COG0671	phosphoesterase, PA-phosphatase related
APECO78_RS10710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
APECO78_RS10715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
APECO78_RS10725	COG0023	Translation Initiation Factor
APECO78_RS10735	COG1349	DNA-binding transcription factor activity
APECO78_RS10745	COG5001	Diguanylate cyclase
APECO78_RS10760	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APECO78_RS10760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APECO78_RS10765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APECO78_RS10775	COG2852	Protein conserved in bacteria
APECO78_RS10780	COG4172	Belongs to the ABC transporter superfamily
APECO78_RS10785	COG4172	Belongs to the ABC transporter superfamily
APECO78_RS10790	COG4171	peptide transport system, permease
APECO78_RS10795	COG4168	peptide transport system, permease
APECO78_RS10800	COG4166	transmembrane transport
APECO78_RS10815	COG0531	amino acid
APECO78_RS10820	COG0174	glutamine synthetase
APECO78_RS10825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
APECO78_RS10830	COG1917	Cupin 2, conserved barrel domain protein
APECO78_RS10830	COG1396	sequence-specific DNA binding
APECO78_RS10835	COG1012	belongs to the aldehyde dehydrogenase family
APECO78_RS10840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APECO78_RS10845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APECO78_RS10850	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
APECO78_RS10855	COG1842	Phage shock protein A
APECO78_RS10865	COG1983	PspC domain protein
APECO78_RS10875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APECO78_RS10880	COG0366	Alpha amylase catalytic
APECO78_RS10885	COG1653	transport
APECO78_RS10890	COG1175	transmembrane transport
APECO78_RS10895	COG0395	ABC-type sugar transport system, permease component
APECO78_RS10900	COG1063	alcohol dehydrogenase
APECO78_RS10905	COG1082	Xylose isomerase domain protein TIM barrel
APECO78_RS10910	COG0673	inositol 2-dehydrogenase activity
APECO78_RS10915	COG1554	hydrolase, family 65, central catalytic
APECO78_RS10920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APECO78_RS10925	COG3842	ATPase activity
APECO78_RS10935	COG1609	Transcriptional regulator
APECO78_RS10940	COG3106	COG3106 Predicted ATPase
APECO78_RS10950	COG3283	Transcriptional regulator of aromatic amino acids metabolism
APECO78_RS10955	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
APECO78_RS10960	COG4948	Mandelate Racemase Muconate Lactonizing
APECO78_RS10965	COG2866	Carboxypeptidase
APECO78_RS10970	COG0702	epimerase
APECO78_RS10975	COG1073	alpha beta
APECO78_RS10980	COG0583	DNA-binding transcription factor activity
APECO78_RS10985	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APECO78_RS10990	COG4166	transmembrane transport
APECO78_RS10995	COG0668	transmembrane transport
APECO78_RS11000	COG3182	Iron-regulated membrane protein
APECO78_RS11005	COG0589	response to stress
APECO78_RS11010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APECO78_RS11015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APECO78_RS11020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
APECO78_RS11030	COG1473	amidohydrolase
APECO78_RS11035	COG1473	amidohydrolase
APECO78_RS11040	COG0583	DNA-binding transcription factor activity
APECO78_RS11045	COG2840	Smr protein MutS2
APECO78_RS11050	COG3706	GGDEF domain
APECO78_RS11065	COG0513	Belongs to the DEAD box helicase family
APECO78_RS11075	COG0589	response to stress
APECO78_RS11080	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APECO78_RS11085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APECO78_RS11085	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APECO78_RS11085	COG0674	pyruvate-flavodoxin oxidoreductase activity
APECO78_RS11085	COG1013	pyruvate-flavodoxin oxidoreductase activity
APECO78_RS11090	COG3042	response to heat
APECO78_RS11095	COG3187	Heat shock protein
APECO78_RS11100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APECO78_RS11105	COG2911	Protein conserved in bacteria
APECO78_RS11115	COG3784	Protein of unknown function (DUF1318)
APECO78_RS11120	COG2207	Transcriptional regulator
APECO78_RS11125	COG1012	belongs to the aldehyde dehydrogenase family
APECO78_RS11130	COG3733	amine oxidase
APECO78_RS11135	COG2030	dehydratase
APECO78_RS11135	COG1012	belongs to the aldehyde dehydrogenase family
APECO78_RS11140	COG3396	Phenylacetate-CoA oxygenase
APECO78_RS11145	COG3460	Phenylacetate-CoA oxygenase
APECO78_RS11150	COG3396	Phenylacetate-CoA oxygenase
APECO78_RS11155	COG2151	metal-sulfur cluster biosynthetic enzyme
APECO78_RS11160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APECO78_RS11165	COG1024	Enoyl-CoA hydratase
APECO78_RS11170	COG1024	Enoyl-CoA hydratase
APECO78_RS11175	COG1250	3-hydroxyacyl-CoA dehydrogenase
APECO78_RS11180	COG2050	protein possibly involved in aromatic compounds catabolism
APECO78_RS11185	COG0183	Belongs to the thiolase family
APECO78_RS11190	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
APECO78_RS11195	COG3327	negative regulation of DNA-templated transcription, initiation
APECO78_RS11200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APECO78_RS11205	COG0667	Aldo Keto reductase
APECO78_RS11215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APECO78_RS11220	COG4589	Belongs to the CDS family
APECO78_RS11225	COG2267	carboxylic ester hydrolase activity
APECO78_RS11240	COG1643	Atp-dependent helicase
APECO78_RS11245	COG1434	Gram-negative-bacterium-type cell wall biogenesis
APECO78_RS11250	COG1012	belongs to the aldehyde dehydrogenase family
APECO78_RS11255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APECO78_RS11260	COG3038	cytochrome b561
APECO78_RS11275	COG0840	transmembrane signaling receptor activity
APECO78_RS11280	COG0583	DNA-binding transcription factor activity
APECO78_RS11285	COG5383	Protein conserved in bacteria
APECO78_RS11300	COG2841	Protein conserved in bacteria
APECO78_RS11305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APECO78_RS11310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APECO78_RS11315	COG1275	C4-dicarboxylate transporter malic acid transport protein
APECO78_RS11320	COG0500	methyltransferase
APECO78_RS11335	COG0675	Transposase, IS605 OrfB family
APECO78_RS11340	COG3135	benzoate transporter
APECO78_RS11345	COG1396	sequence-specific DNA binding
APECO78_RS11350	COG0826	peptidase U32
APECO78_RS11365	COG1598	PFAM Uncharacterised protein family UPF0150
APECO78_RS11370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APECO78_RS11380	COG3842	ATPase activity
APECO78_RS11385	COG1176	ABC-type spermidine putrescine transport system, permease component I
APECO78_RS11390	COG1177	transmembrane transport
APECO78_RS11415	COG3238	Protein conserved in bacteria
APECO78_RS11420	COG1247	-acetyltransferase
APECO78_RS11425	COG2130	NADP-dependent
APECO78_RS11430	COG1802	Transcriptional regulator
APECO78_RS11435	COG4772	TonB-dependent receptor
APECO78_RS11440	COG3391	amine dehydrogenase activity
APECO78_RS11445	COG1113	amino acid transport
APECO78_RS11450	COG0625	glutathione transferase activity
APECO78_RS11465	COG3209	COG3209 Rhs family protein
APECO78_RS11480	COG5433	transposase activity
APECO78_RS11490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APECO78_RS11495	COG2162	N-hydroxyarylamine O-acetyltransferase activity
APECO78_RS11500	COG0384	phenazine biosynthesis protein PhzF
APECO78_RS11505	COG2181	nitrate reductase activity
APECO78_RS11510	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
APECO78_RS11515	COG1140	nitrate reductase beta subunit
APECO78_RS11520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APECO78_RS11525	COG2223	nitrite transmembrane transporter activity
APECO78_RS11535	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APECO78_RS11540	COG0697	spore germination
APECO78_RS11545	COG3383	formate dehydrogenase (NAD+) activity
APECO78_RS11545	COG0243	molybdopterin cofactor binding
APECO78_RS11550	COG0243	molybdopterin cofactor binding
APECO78_RS11550	COG3383	formate dehydrogenase (NAD+) activity
APECO78_RS11555	COG0437	4 iron, 4 sulfur cluster binding
APECO78_RS11560	COG2864	formate dehydrogenase
APECO78_RS11565	COG3093	addiction module antidote protein HigA
APECO78_RS11570	COG1064	alcohol dehydrogenase
APECO78_RS11590	COG1764	response to oxidative stress
APECO78_RS11595	COG4608	Belongs to the ABC transporter superfamily
APECO78_RS11600	COG0444	Belongs to the ABC transporter superfamily
APECO78_RS11605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APECO78_RS11610	COG0601	transmembrane transport
APECO78_RS11615	COG0747	negative chemotaxis
APECO78_RS11620	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
APECO78_RS11625	COG2199	diguanylate cyclase activity
APECO78_RS11625	COG2200	EAL domain
APECO78_RS11625	COG2202	Pas domain
APECO78_RS11635	COG1649	PFAM Uncharacterised BCR, COG1649
APECO78_RS11640	COG0531	amino acid
APECO78_RS11645	COG0076	glutamate decarboxylase activity
APECO78_RS11655	COG0612	Peptidase, M16
APECO78_RS11660	COG4771	TonB-dependent receptor
APECO78_RS11665	COG4178	(ABC) transporter
APECO78_RS11670	COG0641	radical SAM
APECO78_RS11685	COG3119	arylsulfatase activity
APECO78_RS11700	COG0243	molybdopterin cofactor binding
APECO78_RS11705	COG0243	molybdopterin cofactor binding
APECO78_RS11710	COG3539	Fimbrial protein
APECO78_RS11715	COG3539	Fimbrial protein
APECO78_RS11720	COG3539	Fimbrial protein
APECO78_RS11725	COG3188	usher protein
APECO78_RS11735	COG3539	Fimbrial protein
APECO78_RS11740	COG4977	sequence-specific DNA binding
APECO78_RS11745	COG3550	peptidyl-serine autophosphorylation
APECO78_RS11750	COG1396	sequence-specific DNA binding
APECO78_RS11755	COG2911	Protein conserved in bacteria
APECO78_RS11755	COG3210	domain, Protein
APECO78_RS11805	COG3781	membrane
APECO78_RS11815	COG2199	diguanylate cyclase activity
APECO78_RS11830	COG2066	Belongs to the glutaminase family
APECO78_RS11835	COG1012	belongs to the aldehyde dehydrogenase family
APECO78_RS11840	COG0583	DNA-binding transcription factor activity
APECO78_RS11865	COG1846	Transcriptional regulator
APECO78_RS11870	COG4977	sequence-specific DNA binding
APECO78_RS11880	COG2723	6-phospho-beta-galactosidase activity
APECO78_RS11890	COG1447	Phosphotransferase system cellobiose-specific component IIA
APECO78_RS11895	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APECO78_RS11905	COG2188	Transcriptional regulator
APECO78_RS11910	COG0697	spore germination
APECO78_RS11915	COG2814	Major facilitator Superfamily
APECO78_RS11925	COG3706	GGDEF domain
APECO78_RS11930	COG3111	PFAM Bacterial OB fold (BOF) protein
APECO78_RS11935	COG1546	Belongs to the CinA family
APECO78_RS11940	COG0339	signal peptide processing
APECO78_RS11945	COG4221	oxidoreductase activity
APECO78_RS11950	COG1802	Transcriptional regulator
APECO78_RS11960	COG0246	Mannitol dehydrogenase
APECO78_RS11965	COG0477	Major facilitator Superfamily
APECO78_RS11975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APECO78_RS11980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
APECO78_RS11985	COG5301	cellulose 1,4-beta-cellobiosidase activity
APECO78_RS11990	COG0740	serine-type endopeptidase activity
APECO78_RS12030	COG5562	phage envelope protein
APECO78_RS12045	COG1278	Cold shock
APECO78_RS12055	COG3772	lysozyme
APECO78_RS12070	COG1278	Cold shock
APECO78_RS12075	COG1278	Cold shock
APECO78_RS12080	COG0484	heat shock protein binding
APECO78_RS12085	COG1403	HNH endonuclease
APECO78_RS12165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APECO78_RS12175	COG0582	viral genome integration into host DNA
APECO78_RS12180	COG1063	alcohol dehydrogenase
APECO78_RS12185	COG4948	Mandelate Racemase Muconate Lactonizing
APECO78_RS12200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APECO78_RS12215	COG0243	molybdopterin cofactor binding
APECO78_RS12220	COG0243	molybdopterin cofactor binding
APECO78_RS12225	COG0437	4 iron, 4 sulfur cluster binding
APECO78_RS12230	COG3302	dmso reductase anchor subunit
APECO78_RS12235	COG3381	protein complex oligomerization
APECO78_RS12245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APECO78_RS12250	COG1940	carbohydrate kinase activity
APECO78_RS12255	COG0583	DNA-binding transcription factor activity
APECO78_RS12260	COG2814	Major facilitator Superfamily
APECO78_RS12275	COG3591	Belongs to the peptidase S1B family
APECO78_RS12290	COG0628	permease
APECO78_RS12295	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
APECO78_RS12300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
APECO78_RS12310	COG0531	amino acid
APECO78_RS12320	COG3136	membrane protein required for alginate biosynthesis
APECO78_RS12325	COG0745	RESPONSE REGULATOR receiver
APECO78_RS12330	COG2205	protein histidine kinase activity
APECO78_RS12340	COG0114	fumarate hydratase activity
APECO78_RS12345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO78_RS12345	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO78_RS12350	COG1482	cell wall glycoprotein biosynthetic process
APECO78_RS12355	COG5339	Protein conserved in bacteria
APECO78_RS12370	COG3250	beta-galactosidase activity
APECO78_RS12375	COG1309	transcriptional regulator
APECO78_RS12380	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS12385	COG1609	Transcriptional regulator
APECO78_RS12390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO78_RS12390	COG1263	PTS System
APECO78_RS12395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
APECO78_RS12405	COG0673	inositol 2-dehydrogenase activity
APECO78_RS12445	COG4659	FMN binding
APECO78_RS12455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APECO78_RS12465	COG3104	oligopeptide transport
APECO78_RS12470	COG0625	glutathione transferase activity
APECO78_RS12475	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
APECO78_RS12490	COG3895	Periplasmic Protein
APECO78_RS12500	COG3133	Outer membrane lipoprotein
APECO78_RS12515	COG1566	PFAM secretion protein HlyD family protein
APECO78_RS12520	COG1289	transmembrane transporter activity
APECO78_RS12525	COG2032	superoxide dismutase activity
APECO78_RS12530	COG4989	oxidoreductase activity
APECO78_RS12535	COG3313	Fe-S protein
APECO78_RS12540	COG1309	transcriptional regulator
APECO78_RS12545	COG1902	pentaerythritol trinitrate reductase activity
APECO78_RS12550	COG0346	lactoylglutathione lyase activity
APECO78_RS12560	COG1201	RNA secondary structure unwinding
APECO78_RS12565	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APECO78_RS12570	COG0791	NLP P60 protein
APECO78_RS12575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APECO78_RS12580	COG2814	Major facilitator Superfamily
APECO78_RS12595	COG0583	DNA-binding transcription factor activity
APECO78_RS12600	COG2814	Major facilitator Superfamily
APECO78_RS12605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
APECO78_RS12610	COG0307	riboflavin synthase, alpha
APECO78_RS12620	COG3468	outer membrane autotransporter barrel domain protein
APECO78_RS12640	COG4529	Protein conserved in bacteria
APECO78_RS12650	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
APECO78_RS12655	COG0437	4 iron, 4 sulfur cluster binding
APECO78_RS12665	COG2414	aldehyde ferredoxin oxidoreductase
APECO78_RS12670	COG0437	4 iron, 4 sulfur cluster binding
APECO78_RS12680	COG0469	pyruvate kinase activity
APECO78_RS12685	COG4238	major outer membrane lipoprotein
APECO78_RS12690	COG1376	ErfK ybiS ycfS ynhG family protein
APECO78_RS12710	COG0396	ATPase activity
APECO78_RS12715	COG0719	Fe-S assembly protein
APECO78_RS12720	COG0316	Belongs to the HesB IscA family
APECO78_RS12730	COG2050	protein possibly involved in aromatic compounds catabolism
APECO78_RS12735	COG0277	FAD linked oxidase domain protein
APECO78_RS12735	COG0247	lactate metabolic process
APECO78_RS12740	COG0628	permease
APECO78_RS12750	COG0738	Major facilitator superfamily
APECO78_RS12755	COG2271	Major facilitator Superfamily
APECO78_RS12770	COG4670	ketone body catabolic process
APECO78_RS12775	COG1960	acyl-CoA dehydrogenase activity
APECO78_RS12780	COG2207	Transcriptional regulator
APECO78_RS12780	COG1917	Cupin 2, conserved barrel domain protein
APECO78_RS12790	COG2086	electron transfer activity
APECO78_RS12795	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APECO78_RS12800	COG0644	oxidoreductase
APECO78_RS12805	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
APECO78_RS12810	COG0318	PFAM AMP-dependent synthetase and ligase
APECO78_RS12815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APECO78_RS12815	COG0574	Belongs to the PEP-utilizing enzyme family
APECO78_RS12830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APECO78_RS12835	COG4256	Hemin uptake protein
APECO78_RS12845	COG2200	EAL domain
APECO78_RS12850	COG0791	NLP P60 protein
APECO78_RS12860	COG0386	Belongs to the glutathione peroxidase family
APECO78_RS12920	COG3137	Salt-induced outer membrane protein
APECO78_RS12925	COG1105	Belongs to the carbohydrate kinase PfkB family
APECO78_RS12935	COG3001	Fructosamine kinase
APECO78_RS12945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APECO78_RS12950	COG1988	membrane-bound metal-dependent
APECO78_RS12955	COG1823	symporter activity
APECO78_RS12970	COG0753	catalase activity
APECO78_RS12980	COG1486	melibiose metabolic process
APECO78_RS12985	COG2169	Transcriptional regulator
APECO78_RS12985	COG1917	Cupin 2, conserved barrel domain protein
APECO78_RS12990	COG1447	Phosphotransferase system cellobiose-specific component IIA
APECO78_RS12995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APECO78_RS13000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
APECO78_RS13005	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APECO78_RS13020	COG0322	excinuclease ABC activity
APECO78_RS13030	COG3678	ATP-independent chaperone mediated protein folding
APECO78_RS13060	COG0708	Exodeoxyribonuclease III
APECO78_RS13065	COG0398	Pfam SNARE associated Golgi protein
APECO78_RS13075	COG0398	Pfam SNARE associated Golgi protein
APECO78_RS13080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
APECO78_RS13085	COG4134	Bacterial extracellular solute-binding protein
APECO78_RS13090	COG4135	transport system, permease component
APECO78_RS13095	COG4136	ATPase activity
APECO78_RS13100	COG2897	thiosulfate sulfurtransferase activity
APECO78_RS13105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APECO78_RS13110	COG0494	nUDIX hydrolase
APECO78_RS13120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APECO78_RS13130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APECO78_RS13145	COG0778	Nitroreductase
APECO78_RS13155	COG0616	signal peptide processing
APECO78_RS13160	COG0252	asparaginase activity
APECO78_RS13165	COG1335	isochorismatase
APECO78_RS13170	COG3139	Protein of unknown function (DUF1315)
APECO78_RS13180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APECO78_RS13185	COG0676	glucose-6-phosphate 1-epimerase activity
APECO78_RS13190	COG0656	L-ascorbic acid biosynthetic process
APECO78_RS13195	COG3713	MltA-interacting MipA family protein
APECO78_RS13200	COG2766	serine protein kinase
APECO78_RS13210	COG2199	diguanylate cyclase activity
APECO78_RS13215	COG2199	diguanylate cyclase activity
APECO78_RS13220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
APECO78_RS13235	COG2207	Transcriptional regulator
APECO78_RS13240	COG2807	transmembrane transport
APECO78_RS13245	COG3189	MarR family transcriptional regulator
APECO78_RS13250	COG3042	response to heat
APECO78_RS13255	COG2203	Gaf domain
APECO78_RS13255	COG2199	diguanylate cyclase activity
APECO78_RS13265	COG2261	transglycosylase associated protein
APECO78_RS13275	COG3615	Tellurite resistance protein tehB
APECO78_RS13285	COG0583	DNA-binding transcription factor activity
APECO78_RS13290	COG0473	3-isopropylmalate dehydrogenase activity
APECO78_RS13295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
APECO78_RS13300	COG4638	Rieske (2fe-2S)
APECO78_RS13305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APECO78_RS13310	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
APECO78_RS13315	COG0318	PFAM AMP-dependent synthetase and ligase
APECO78_RS13320	COG3065	identical protein binding
APECO78_RS13325	COG1214	PFAM Peptidase M22, glycoprotease
APECO78_RS13330	COG1199	ATP-dependent helicase activity
APECO78_RS13335	COG0251	oxidation-reduction process
APECO78_RS13350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APECO78_RS13360	COG1760	l-serine dehydratase
APECO78_RS13365	COG2200	EAL domain
APECO78_RS13370	COG1253	flavin adenine dinucleotide binding
APECO78_RS13380	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS13380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO78_RS13385	COG3715	PTS system
APECO78_RS13390	COG3716	PTS system mannose fructose sorbose family IID component
APECO78_RS13410	COG2226	methyltransferase
APECO78_RS13445	COG1414	Transcriptional regulator
APECO78_RS13450	COG2814	Major facilitator Superfamily
APECO78_RS13460	COG0793	Belongs to the peptidase S41A family
APECO78_RS13470	COG1956	GAF domain-containing protein
APECO78_RS13475	COG2995	paraquat-inducible protein a
APECO78_RS13480	COG3008	intermembrane lipid transfer
APECO78_RS13500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APECO78_RS13515	COG1276	copper resistance
APECO78_RS13520	COG2372	response to copper ion
APECO78_RS13530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APECO78_RS13535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APECO78_RS13540	COG1770	oligopeptidase
APECO78_RS13545	COG2979	Protein of unknown function (DUF533)
APECO78_RS13560	COG3141	response to X-ray
APECO78_RS13570	COG0800	Aldolase
APECO78_RS13575	COG0129	dihydroxy-acid dehydratase activity
APECO78_RS13580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APECO78_RS13590	COG1737	Transcriptional regulator
APECO78_RS13595	COG0469	pyruvate kinase activity
APECO78_RS13600	COG1560	Kdo2-lipid A biosynthetic process
APECO78_RS13605	COG0739	heme binding
APECO78_RS13610	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
APECO78_RS13620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APECO78_RS13645	COG0217	transcriptional regulatory protein
APECO78_RS13650	COG0494	nUDIX hydrolase
APECO78_RS13660	COG1335	isochorismatase
APECO78_RS13665	COG1801	Protein of unknown function DUF72
APECO78_RS13670	COG3788	relative of glutathione S-transferase, MAPEG superfamily
APECO78_RS13685	COG0243	molybdopterin cofactor binding
APECO78_RS13690	COG3005	denitrification pathway
APECO78_RS13700	COG3102	Protein conserved in bacteria
APECO78_RS13710	COG3755	Protein conserved in bacteria
APECO78_RS13720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APECO78_RS13725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
APECO78_RS13730	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
APECO78_RS13735	COG0745	RESPONSE REGULATOR receiver
APECO78_RS13745	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APECO78_RS13750	COG0840	transmembrane signaling receptor activity
APECO78_RS13755	COG0840	transmembrane signaling receptor activity
APECO78_RS13760	COG0835	chemotaxis
APECO78_RS13765	COG0643	Histidine kinase
APECO78_RS13765	COG2198	Histidine kinase
APECO78_RS13770	COG1360	Flagellar Motor Protein
APECO78_RS13775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
APECO78_RS13790	COG0589	response to stress
APECO78_RS13800	COG1877	trehalose-phosphatase activity
APECO78_RS13805	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO78_RS13810	COG1129	ABC transporter
APECO78_RS13815	COG1879	ABC-type sugar transport system periplasmic component
APECO78_RS13820	COG1528	Iron-storage protein
APECO78_RS13840	COG1528	Iron-storage protein
APECO78_RS13850	COG0814	amino acid
APECO78_RS13855	COG3012	SEC-C Motif Domain Protein
APECO78_RS13855	COG3318	Belongs to the UPF0149 family
APECO78_RS13885	COG2197	response regulator
APECO78_RS13900	COG2197	response regulator
APECO78_RS13905	COG1126	abc transporter atp-binding protein
APECO78_RS13910	COG0765	amino acid transport
APECO78_RS13920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO78_RS13930	COG1191	sigma factor activity
APECO78_RS13940	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
APECO78_RS13945	COG1516	flagellar protein fliS
APECO78_RS13955	COG0366	Alpha amylase catalytic
APECO78_RS13965	COG2391	methyltransferase activity
APECO78_RS13970	COG0425	Belongs to the sulfur carrier protein TusA family
APECO78_RS13975	COG2135	peptidase activity
APECO78_RS13980	COG0675	Transposase, IS605 OrfB family
APECO78_RS13995	COG2207	Transcriptional regulator
APECO78_RS14000	COG1881	PFAM PEBP family protein
APECO78_RS14020	COG1766	The M ring may be actively involved in energy transduction
APECO78_RS14025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APECO78_RS14030	COG1317	bacterial-type flagellum organization
APECO78_RS14035	COG1157	protein secretion by the type III secretion system
APECO78_RS14040	COG2882	bacterial-type flagellum organization
APECO78_RS14045	COG3144	bacterial-type flagellum assembly
APECO78_RS14050	COG1580	Controls the rotational direction of flagella during chemotaxis
APECO78_RS14055	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APECO78_RS14060	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
APECO78_RS14065	COG3190	flagellar
APECO78_RS14070	COG1338	Plays a role in the flagellum-specific transport system
APECO78_RS14075	COG1987	bacterial-type flagellum assembly
APECO78_RS14080	COG1684	flagellar biosynthetic protein fliR
APECO78_RS14085	COG2197	response regulator
APECO78_RS14110	COG5475	Uncharacterized small protein (DUF2158)
APECO78_RS14115	COG2354	Protein conserved in bacteria
APECO78_RS14120	COG0697	spore germination
APECO78_RS14125	COG3727	T/G mismatch-specific endonuclease activity
APECO78_RS14130	COG0270	DNA (cytosine-5-)-methyltransferase activity
APECO78_RS14135	COG1418	mRNA catabolic process
APECO78_RS14150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APECO78_RS14165	COG2205	protein histidine kinase activity
APECO78_RS14170	COG0745	RESPONSE REGULATOR receiver
APECO78_RS14175	COG2351	hydroxyisourate hydrolase activity
APECO78_RS14190	COG3443	Belongs to the bacterial solute-binding protein 9 family
APECO78_RS14195	COG3038	cytochrome b561
APECO78_RS14285	COG0477	Major facilitator Superfamily
APECO78_RS14290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
APECO78_RS14295	COG0217	transcriptional regulatory protein
APECO78_RS14305	COG0534	Mate efflux family protein
APECO78_RS14315	COG0583	DNA-binding transcription factor activity
APECO78_RS14320	COG0583	DNA-binding transcription factor activity
APECO78_RS14330	COG1376	ErfK ybiS ycfS ynhG family protein
APECO78_RS14345	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
APECO78_RS14350	COG4917	ethanolamine utilization protein
APECO78_RS14360	COG1289	transmembrane transporter activity
APECO78_RS14370	COG1686	Belongs to the peptidase S11 family
APECO78_RS14375	COG2925	Exonuclease
APECO78_RS14380	COG0425	Belongs to the sulfur carrier protein TusA family
APECO78_RS14385	COG2391	methyltransferase activity
APECO78_RS14390	COG0531	amino acid
APECO78_RS14395	COG0583	DNA-binding transcription factor activity
APECO78_RS14400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APECO78_RS14405	COG4115	mRNA cleavage
APECO78_RS14410	COG2161	toxin-antitoxin pair type II binding
APECO78_RS14420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APECO78_RS14430	COG0131	Imidazoleglycerol-phosphate dehydratase
APECO78_RS14430	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
APECO78_RS14435	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APECO78_RS14460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APECO78_RS14465	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APECO78_RS14505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APECO78_RS14510	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APECO78_RS14510	COG0662	Cupin 2, conserved barrel domain protein
APECO78_RS14515	COG0438	transferase activity, transferring glycosyl groups
APECO78_RS14525	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APECO78_RS14535	COG0438	transferase activity, transferring glycosyl groups
APECO78_RS14540	COG2327	Polysaccharide pyruvyl transferase
APECO78_RS14545	COG2244	polysaccharide biosynthetic process
APECO78_RS14550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
APECO78_RS14555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APECO78_RS14560	COG0662	Cupin 2, conserved barrel domain protein
APECO78_RS14560	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APECO78_RS14565	COG0297	glycogen (starch) synthase activity
APECO78_RS14570	COG1051	belongs to the nudix hydrolase family
APECO78_RS14575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APECO78_RS14580	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
APECO78_RS14585	COG0110	maltose O-acetyltransferase activity
APECO78_RS14590	COG1216	Glycosyl transferase, family 2
APECO78_RS14600	COG0438	transferase activity, transferring glycosyl groups
APECO78_RS14605	COG1045	serine acetyltransferase
APECO78_RS14610	COG0463	Glycosyl transferase, family 2
APECO78_RS14615	COG3206	protein involved in exopolysaccharide biosynthesis
APECO78_RS14615	COG0489	protein tyrosine kinase activity
APECO78_RS14620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APECO78_RS14625	COG1596	polysaccharide export
APECO78_RS14630	COG1253	flavin adenine dinucleotide binding
APECO78_RS14635	COG2982	Protein involved in outer membrane biogenesis
APECO78_RS14645	COG0572	uridine kinase
APECO78_RS14650	COG5002	protein histidine kinase activity
APECO78_RS14650	COG3447	MASE1 domain protein
APECO78_RS14650	COG5001	Diguanylate cyclase
APECO78_RS14655	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
APECO78_RS14660	COG0443	Heat shock 70 kDa protein
APECO78_RS14665	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
APECO78_RS14670	COG3779	Protein conserved in bacteria
APECO78_RS14675	COG0631	protein serine/threonine phosphatase activity
APECO78_RS14680	COG4245	von Willebrand factor, type A
APECO78_RS14705	COG2205	protein histidine kinase activity
APECO78_RS14710	COG0745	RESPONSE REGULATOR receiver
APECO78_RS14720	COG3609	addiction module antidote protein, CC2985 family
APECO78_RS14730	COG0826	peptidase U32
APECO78_RS14755	COG1063	alcohol dehydrogenase
APECO78_RS14760	COG3775	system Galactitol-specific IIC component
APECO78_RS14765	COG3414	Phosphotransferase system galactitol-specific IIB component
APECO78_RS14770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS14785	COG1830	Aldolase
APECO78_RS14790	COG2211	Major facilitator Superfamily
APECO78_RS14795	COG1397	ADP-ribosylglycohydrolase
APECO78_RS14800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO78_RS14805	COG2188	Transcriptional regulator
APECO78_RS14810	COG3757	hydrolase, family 25
APECO78_RS14815	COG0351	phosphomethylpyrimidine kinase
APECO78_RS14835	COG5455	response to cobalt ion
APECO78_RS14840	COG3539	Fimbrial protein
APECO78_RS14845	COG3188	usher protein
APECO78_RS14850	COG3121	Chaperone
APECO78_RS14855	COG3539	Fimbrial protein
APECO78_RS14870	COG0489	protein tyrosine kinase activity
APECO78_RS14880	COG3831	ATPase activity
APECO78_RS14895	COG0714	Associated with various cellular activities
APECO78_RS14900	COG2425	protein containing a von Willebrand factor type A (vWA) domain
APECO78_RS14905	COG3552	Protein containing von Willebrand factor type A (VWA) domain
APECO78_RS14910	COG4715	Zinc finger, swim domain protein
APECO78_RS14915	COG4808	Protein conserved in bacteria
APECO78_RS14920	COG4807	Protein conserved in bacteria
APECO78_RS14925	COG3279	Response regulator of the LytR AlgR family
APECO78_RS14930	COG3275	phosphorelay sensor kinase activity
APECO78_RS14935	COG0789	Transcriptional regulator
APECO78_RS14945	COG1174	glycine betaine transport
APECO78_RS14950	COG1125	glycine betaine transport
APECO78_RS14955	COG1174	glycine betaine transport
APECO78_RS14960	COG1732	Glycine betaine
APECO78_RS14965	COG1472	Belongs to the glycosyl hydrolase 3 family
APECO78_RS14970	COG0277	FAD linked oxidase domain protein
APECO78_RS14975	COG1686	Belongs to the peptidase S11 family
APECO78_RS14985	COG0586	Pfam SNARE associated Golgi protein
APECO78_RS14990	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS15005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APECO78_RS15015	COG1346	cytolysis
APECO78_RS15025	COG2949	membrane
APECO78_RS15035	COG0493	'glutamate synthase
APECO78_RS15040	COG0167	dihydroorotate dehydrogenase activity
APECO78_RS15040	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APECO78_RS15045	COG4211	Belongs to the binding-protein-dependent transport system permease family
APECO78_RS15050	COG1129	ABC transporter
APECO78_RS15055	COG1879	ABC-type sugar transport system periplasmic component
APECO78_RS15060	COG1609	Transcriptional regulator
APECO78_RS15070	COG2311	Membrane
APECO78_RS15085	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
APECO78_RS15095	COG0833	amino acid
APECO78_RS15100	COG0583	DNA-binding transcription factor activity
APECO78_RS15105	COG2855	membrane
APECO78_RS15115	COG1522	sequence-specific DNA binding
APECO78_RS15115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO78_RS15120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APECO78_RS15130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APECO78_RS15135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APECO78_RS15140	COG2313	pseudouridylate synthase activity
APECO78_RS15145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO78_RS15150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS15150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS15150	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
APECO78_RS15155	COG1105	Belongs to the carbohydrate kinase PfkB family
APECO78_RS15160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS15160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS15165	COG2814	Major facilitator Superfamily
APECO78_RS15180	COG0246	Mannitol dehydrogenase
APECO78_RS15185	COG0523	cobalamin synthesis protein
APECO78_RS15190	COG0671	phosphoesterase, PA-phosphatase related
APECO78_RS15195	COG0791	NLP P60 protein
APECO78_RS15200	COG2200	EAL domain
APECO78_RS15205	COG4166	transmembrane transport
APECO78_RS15210	COG4174	ABC transporter (Permease)
APECO78_RS15215	COG4239	(ABC) transporter, permease
APECO78_RS15220	COG4172	Belongs to the ABC transporter superfamily
APECO78_RS15230	COG2814	Major facilitator Superfamily
APECO78_RS15235	COG1187	pseudouridine synthase activity
APECO78_RS15240	COG1061	Type III restriction enzyme res subunit
APECO78_RS15260	COG3083	sulfuric ester hydrolase activity
APECO78_RS15290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
APECO78_RS15330	COG3179	chitinase
APECO78_RS15355	COG4725	Belongs to the MT-A70-like family
APECO78_RS15365	COG5532	Uncharacterized conserved protein (DUF2303)
APECO78_RS15370	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
APECO78_RS15405	COG3468	outer membrane autotransporter barrel domain protein
APECO78_RS15415	COG2197	response regulator
APECO78_RS15420	COG3088	subunit of a heme lyase
APECO78_RS15420	COG4235	cytochrome complex assembly
APECO78_RS15425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APECO78_RS15430	COG1138	Cytochrome C-type biogenesis protein
APECO78_RS15440	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APECO78_RS15445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APECO78_RS15450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APECO78_RS15455	COG4133	protoheme IX ABC transporter activity
APECO78_RS15460	COG3005	denitrification pathway
APECO78_RS15465	COG3043	anaerobic respiration
APECO78_RS15470	COG0348	domain, Protein
APECO78_RS15475	COG0437	4 iron, 4 sulfur cluster binding
APECO78_RS15485	COG3062	negative regulation of establishment of protein localization
APECO78_RS15490	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS15490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS15510	COG4615	Cyclic peptide transporter
APECO78_RS15515	COG3145	DNA-N1-methyladenine dioxygenase activity
APECO78_RS15520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
APECO78_RS15520	COG2169	Transcriptional regulator
APECO78_RS15525	COG1477	protein flavinylation
APECO78_RS15530	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
APECO78_RS15545	COG0642	Histidine kinase
APECO78_RS15545	COG2198	Histidine kinase
APECO78_RS15550	COG2197	response regulator
APECO78_RS15555	COG0784	Response regulator, receiver
APECO78_RS15555	COG2205	protein histidine kinase activity
APECO78_RS15560	COG3852	Histidine kinase
APECO78_RS15565	COG2204	response regulator
APECO78_RS15570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
APECO78_RS15575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
APECO78_RS15580	COG2031	fatty acid transporter
APECO78_RS15585	COG0183	Belongs to the thiolase family
APECO78_RS15590	COG4676	Protein conserved in bacteria
APECO78_RS15595	COG5445	Predicted secreted protein (DUF2300)
APECO78_RS15600	COG2373	Large extracellular alpha-helical protein
APECO78_RS15605	COG3234	Protein of unknown function (DUF1175)
APECO78_RS15610	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
APECO78_RS15615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APECO78_RS15625	COG3468	outer membrane autotransporter barrel domain protein
APECO78_RS15635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APECO78_RS15640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APECO78_RS15645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APECO78_RS15650	COG3642	lipopolysaccharide core region biosynthetic process
APECO78_RS15655	COG0583	DNA-binding transcription factor activity
APECO78_RS15665	COG0584	glycerophosphoryl diester phosphodiesterase
APECO78_RS15670	COG2271	Major facilitator Superfamily
APECO78_RS15675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APECO78_RS15685	COG0247	lactate metabolic process
APECO78_RS15690	COG5464	transposase or invertase
APECO78_RS15760	COG0318	PFAM AMP-dependent synthetase and ligase
APECO78_RS15770	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APECO78_RS15785	COG1169	isochorismate synthase
APECO78_RS15790	COG4575	ribosome binding
APECO78_RS15795	COG2153	protein acetylation
APECO78_RS15810	COG2304	oxidoreductase activity
APECO78_RS15815	COG2234	aminopeptidase activity
APECO78_RS15830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APECO78_RS15835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APECO78_RS15845	COG0839	Belongs to the complex I subunit 6 family
APECO78_RS15860	COG1034	ATP synthesis coupled electron transport
APECO78_RS15865	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APECO78_RS15870	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
APECO78_RS15890	COG0583	DNA-binding transcription factor activity
APECO78_RS15895	COG0436	Aminotransferase
APECO78_RS15905	COG0490	domain, Protein
APECO78_RS15905	COG0471	metal ion transport
APECO78_RS15910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APECO78_RS15930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APECO78_RS15935	COG0280	phosphate acetyltransferase
APECO78_RS15935	COG0857	belongs to the CobB CobQ family
APECO78_RS15940	COG1288	antiporter activity
APECO78_RS15945	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
APECO78_RS15950	COG0622	Phosphoesterase
APECO78_RS15955	COG0625	glutathione transferase activity
APECO78_RS15960	COG0625	glutathione transferase activity
APECO78_RS15965	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APECO78_RS15970	COG1090	epimerase
APECO78_RS15975	COG5464	transposase or invertase
APECO78_RS15980	COG4598	ABC transporter
APECO78_RS15985	COG4160	amino acid transport
APECO78_RS15990	COG4215	(ABC) transporter
APECO78_RS15995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO78_RS16000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO78_RS16005	COG0163	prenyltransferase activity
APECO78_RS16010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APECO78_RS16015	COG1286	toxin biosynthetic process
APECO78_RS16020	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
APECO78_RS16025	COG0285	dihydrofolate synthase activity
APECO78_RS16035	COG0586	Pfam SNARE associated Golgi protein
APECO78_RS16045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APECO78_RS16060	COG2814	Major facilitator Superfamily
APECO78_RS16065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APECO78_RS16080	COG3101	peptidyl-lysine hydroxylation
APECO78_RS16085	COG0730	response to heat
APECO78_RS16115	COG3539	Fimbrial protein
APECO78_RS16120	COG3539	Fimbrial protein
APECO78_RS16125	COG3539	Fimbrial protein
APECO78_RS16130	COG3121	Chaperone
APECO78_RS16135	COG3188	usher protein
APECO78_RS16140	COG3539	Fimbrial protein
APECO78_RS16145	COG2062	phosphohistidine phosphatase, SixA
APECO78_RS16160	COG3691	Protein conserved in bacteria
APECO78_RS16165	COG2067	long-chain fatty acid transport protein
APECO78_RS16175	COG2853	Lipoprotein
APECO78_RS16180	COG2116	formate transmembrane transporter activity
APECO78_RS16220	COG2610	gluconate transmembrane transporter activity
APECO78_RS16230	COG0477	Major facilitator Superfamily
APECO78_RS16235	COG1566	PFAM secretion protein HlyD family protein
APECO78_RS16240	COG2197	response regulator
APECO78_RS16245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO78_RS16245	COG0784	Response regulator, receiver
APECO78_RS16245	COG2198	Histidine kinase
APECO78_RS16245	COG2205	protein histidine kinase activity
APECO78_RS16250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
APECO78_RS16255	COG0679	Auxin Efflux Carrier
APECO78_RS16260	COG0028	Belongs to the TPP enzyme family
APECO78_RS16290	COG1560	Kdo2-lipid A biosynthetic process
APECO78_RS16295	COG0436	Aminotransferase
APECO78_RS16300	COG3275	phosphorelay sensor kinase activity
APECO78_RS16305	COG3279	Response regulator of the LytR AlgR family
APECO78_RS16310	COG2207	Transcriptional regulator
APECO78_RS16320	COG1363	Peptidase, m42
APECO78_RS16325	COG0006	proline dipeptidase activity
APECO78_RS16330	COG0006	proline dipeptidase activity
APECO78_RS16335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS16340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
APECO78_RS16370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APECO78_RS16375	COG2199	diguanylate cyclase activity
APECO78_RS16375	COG2200	EAL domain
APECO78_RS16390	COG3415	Transposase
APECO78_RS16395	COG3415	Transposase
APECO78_RS16425	COG0583	DNA-binding transcription factor activity
APECO78_RS16435	COG2211	Major facilitator Superfamily
APECO78_RS16440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APECO78_RS16450	COG0583	DNA-binding transcription factor activity
APECO78_RS16455	COG0385	Bile acid
APECO78_RS16460	COG3530	Putative quorum-sensing-regulated virulence factor
APECO78_RS16480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APECO78_RS16485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS16490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APECO78_RS16495	COG2190	(PTS) system
APECO78_RS16510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APECO78_RS16515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APECO78_RS16520	COG4208	sulfate ABC transporter
APECO78_RS16525	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APECO78_RS16530	COG4150	thiosulfate binding
APECO78_RS16535	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS16550	COG1263	PTS System
APECO78_RS16550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO78_RS16555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
APECO78_RS16560	COG2837	iron assimilation
APECO78_RS16580	COG0860	N-Acetylmuramoyl-L-alanine amidase
APECO78_RS16590	COG2207	Transcriptional regulator
APECO78_RS16595	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APECO78_RS16600	COG4816	utilization protein
APECO78_RS16610	COG4303	Ethanolamine ammonia lyase large subunit
APECO78_RS16620	COG3192	ethanolamine utilization protein
APECO78_RS16625	COG1454	alcohol dehydrogenase
APECO78_RS16630	COG4820	ethanolamine utilization protein (EutJ)
APECO78_RS16635	COG1012	belongs to the aldehyde dehydrogenase family
APECO78_RS16640	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
APECO78_RS16645	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APECO78_RS16650	COG0280	phosphate acetyltransferase
APECO78_RS16655	COG0280	phosphate acetyltransferase
APECO78_RS16660	COG4812	Cobalamin adenosyltransferase
APECO78_RS16665	COG4766	ethanolamine catabolic process
APECO78_RS16670	COG4917	ethanolamine utilization protein
APECO78_RS16675	COG4810	utilization protein
APECO78_RS16680	COG0280	phosphate acetyltransferase
APECO78_RS16680	COG0281	malic enzyme
APECO78_RS16685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APECO78_RS16690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APECO78_RS16695	COG5342	invasion associated locus B
APECO78_RS16705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS16705	COG0493	'glutamate synthase
APECO78_RS16710	COG3850	Histidine kinase
APECO78_RS16715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO78_RS16725	COG1393	Belongs to the ArsC family
APECO78_RS16740	COG0400	carboxylic ester hydrolase activity
APECO78_RS16750	COG2321	neutral zinc metallopeptidase
APECO78_RS16775	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
APECO78_RS16785	COG2716	regulation of RNA biosynthetic process
APECO78_RS16790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APECO78_RS16795	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS16800	COG0651	ATP synthesis coupled electron transport
APECO78_RS16805	COG0651	ATP synthesis coupled electron transport
APECO78_RS16810	COG0650	Formate hydrogenlyase subunit 4
APECO78_RS16815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APECO78_RS16820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APECO78_RS16825	COG4237	Hydrogenase 4 membrane
APECO78_RS16830	COG0651	ATP synthesis coupled electron transport
APECO78_RS16835	COG3261	NADH dehydrogenase
APECO78_RS16835	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
APECO78_RS16840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APECO78_RS16845	COG3260	NADH ubiquinone oxidoreductase 20
APECO78_RS16855	COG3604	Transcriptional regulator
APECO78_RS16860	COG2116	formate transmembrane transporter activity
APECO78_RS16865	COG0628	permease
APECO78_RS16870	COG4783	chaperone-mediated protein folding
APECO78_RS16875	COG1393	Belongs to the ArsC family
APECO78_RS16885	COG2233	PERMEase
APECO78_RS16900	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APECO78_RS16905	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APECO78_RS16910	COG0248	Ppx GppA phosphatase
APECO78_RS16915	COG2200	EAL domain
APECO78_RS16930	COG3133	Outer membrane lipoprotein
APECO78_RS16945	COG0516	GMP reductase activity
APECO78_RS16945	COG0517	IMP dehydrogenase activity
APECO78_RS16955	COG1645	bacterial-type flagellum-dependent swarming motility
APECO78_RS16970	COG2976	Protein conserved in bacteria
APECO78_RS17000	COG4953	penicillin-binding protein 1C
APECO78_RS17005	COG2373	Large extracellular alpha-helical protein
APECO78_RS17010	COG2897	thiosulfate sulfurtransferase activity
APECO78_RS17025	COG2975	iron-sulfur cluster assembly
APECO78_RS17030	COG0633	Ferredoxin
APECO78_RS17050	COG0822	iron-sulfur transferase activity
APECO78_RS17070	COG0483	inositol monophosphate 1-phosphatase activity
APECO78_RS17075	COG1073	alpha beta
APECO78_RS17080	COG3711	transcriptional antiterminator
APECO78_RS17085	COG2814	Major facilitator Superfamily
APECO78_RS17090	COG0583	DNA-binding transcription factor activity
APECO78_RS17095	COG4638	Rieske (2fe-2S)
APECO78_RS17120	COG2259	Doxx family
APECO78_RS17125	COG2017	converts alpha-aldose to the beta-anomer
APECO78_RS17130	COG1063	alcohol dehydrogenase
APECO78_RS17135	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO78_RS17140	COG1129	ABC transporter
APECO78_RS17145	COG1879	ABC-type sugar transport system periplasmic component
APECO78_RS17150	COG0457	Tetratricopeptide repeat
APECO78_RS17155	COG1940	carbohydrate kinase activity
APECO78_RS17165	COG1017	nitric oxide dioxygenase activity
APECO78_RS17165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APECO78_RS17170	COG0347	Belongs to the P(II) protein family
APECO78_RS17175	COG2204	response regulator
APECO78_RS17180	COG3170	Tfp pilus assembly protein FimV
APECO78_RS17185	COG2205	protein histidine kinase activity
APECO78_RS17205	COG0560	Phosphoserine phosphatase
APECO78_RS17210	COG1737	Transcriptional regulator
APECO78_RS17215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS17240	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APECO78_RS17260	COG0681	Belongs to the peptidase S26 family
APECO78_RS17270	COG3086	response to oxidative stress
APECO78_RS17275	COG3026	antisigma factor binding
APECO78_RS17280	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
APECO78_RS17285	COG1595	DNA-templated transcription, initiation
APECO78_RS17295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APECO78_RS17305	COG0513	Belongs to the DEAD box helicase family
APECO78_RS17315	COG0583	DNA-binding transcription factor activity
APECO78_RS17335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APECO78_RS17345	COG3118	belongs to the thioredoxin family
APECO78_RS17350	COG3148	PFAM DTW domain containing protein
APECO78_RS17355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APECO78_RS17355	COG1042	CoA-binding domain protein
APECO78_RS17355	COG0045	succinate-CoA ligase (ADP-forming) activity
APECO78_RS17360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
APECO78_RS17365	COG5544	Lipoprotein
APECO78_RS17370	COG0477	Major facilitator Superfamily
APECO78_RS17405	COG0542	response to heat
APECO78_RS17415	COG0564	pseudouridine synthase activity
APECO78_RS17420	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APECO78_RS17430	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APECO78_RS17435	COG0077	Prephenate dehydratase
APECO78_RS17435	COG1605	Chorismate mutase
APECO78_RS17440	COG0287	Prephenate dehydrogenase
APECO78_RS17440	COG1605	Chorismate mutase
APECO78_RS17445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
APECO78_RS17460	COG2199	diguanylate cyclase activity
APECO78_RS17465	COG2885	chlorophyll binding
APECO78_RS17490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APECO78_RS17495	COG4137	Cytochrome C assembly protein
APECO78_RS17500	COG4536	flavin adenine dinucleotide binding
APECO78_RS17520	COG0497	DNA recombination
APECO78_RS17525	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APECO78_RS17535	COG2867	negative regulation of translational initiation
APECO78_RS17545	COG0582	viral genome integration into host DNA
APECO78_RS17555	COG1475	DNA binding
APECO78_RS17565	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APECO78_RS17570	COG0732	type I restriction modification DNA specificity domain
APECO78_RS17575	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APECO78_RS17605	COG0366	Alpha amylase catalytic
APECO78_RS17610	COG0366	Alpha amylase catalytic
APECO78_RS17620	COG0579	oxidoreductase
APECO78_RS17625	COG1012	belongs to the aldehyde dehydrogenase family
APECO78_RS17630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
APECO78_RS17635	COG1113	amino acid transport
APECO78_RS17640	COG1802	Transcriptional regulator
APECO78_RS17645	COG1652	LysM domain
APECO78_RS17650	COG0401	homolog of Blt101
APECO78_RS17655	COG0640	Transcriptional regulator
APECO78_RS17660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APECO78_RS17665	COG2916	Histone family protein nucleoid-structuring protein H-NS
APECO78_RS17680	COG4575	ribosome binding
APECO78_RS17685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APECO78_RS17695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APECO78_RS17700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APECO78_RS17705	COG4175	Glycine betaine
APECO78_RS17710	COG4176	ABC-type proline glycine betaine transport system permease component
APECO78_RS17715	COG2113	Glycine betaine
APECO78_RS17720	COG2814	Major facilitator Superfamily
APECO78_RS17725	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
APECO78_RS17735	COG1846	Transcriptional regulator
APECO78_RS17740	COG1566	PFAM secretion protein HlyD family protein
APECO78_RS17745	COG2814	Major facilitator Superfamily
APECO78_RS17760	COG1238	metal cluster binding
APECO78_RS17765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APECO78_RS17795	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
APECO78_RS17820	COG1546	Belongs to the CinA family
APECO78_RS17825	COG2951	lytic endotransglycosylase activity
APECO78_RS17830	COG3730	PTS system glucitol sorbitol-specific
APECO78_RS17835	COG3732	PTS system glucitol sorbitol-specific
APECO78_RS17845	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS17850	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS17855	COG1349	DNA-binding transcription factor activity
APECO78_RS17880	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APECO78_RS17885	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS17890	COG1609	Transcriptional regulator
APECO78_RS17895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO78_RS17895	COG1263	PTS System
APECO78_RS17900	COG2723	6-phospho-beta-galactosidase activity
APECO78_RS17905	COG5499	transcription regulator containing HTH domain
APECO78_RS17910	COG4680	protein conserved in bacteria
APECO78_RS17920	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APECO78_RS17930	COG3260	NADH ubiquinone oxidoreductase 20
APECO78_RS17935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APECO78_RS17940	COG3261	NADH dehydrogenase
APECO78_RS17940	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
APECO78_RS17945	COG0650	Formate hydrogenlyase subunit 4
APECO78_RS17950	COG0651	ATP synthesis coupled electron transport
APECO78_RS17955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS17970	COG0375	protein maturation
APECO78_RS17975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APECO78_RS17980	COG0298	carbon dioxide binding
APECO78_RS17985	COG0409	Hydrogenase expression formation protein
APECO78_RS17990	COG0309	Hydrogenase expression formation protein (HypE)
APECO78_RS17995	COG3604	Transcriptional regulator
APECO78_RS18010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
APECO78_RS18015	COG1349	DNA-binding transcription factor activity
APECO78_RS18020	COG2084	Dehydrogenase
APECO78_RS18025	COG3395	kinase activity
APECO78_RS18030	COG0235	Class ii aldolase
APECO78_RS18035	COG3622	Belongs to the hyi family
APECO78_RS18040	COG2610	gluconate transmembrane transporter activity
APECO78_RS18045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APECO78_RS18050	COG1388	LysM domain
APECO78_RS18050	COG4942	peptidase
APECO78_RS18105	COG2234	aminopeptidase activity
APECO78_RS18110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
APECO78_RS18115	COG1518	maintenance of DNA repeat elements
APECO78_RS18130	COG1857	crispr-associated protein
APECO78_RS18145	COG1203	CRISPR-associated helicase, Cas3
APECO78_RS18175	COG0720	synthase
APECO78_RS18180	COG0644	oxidoreductase
APECO78_RS18185	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
APECO78_RS18190	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
APECO78_RS18195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
APECO78_RS18200	COG2086	electron transfer activity
APECO78_RS18205	COG0477	Major facilitator Superfamily
APECO78_RS18210	COG0277	FAD linked oxidase domain protein
APECO78_RS18215	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS18220	COG2223	nitrite transmembrane transporter activity
APECO78_RS18225	COG1070	Carbohydrate kinase
APECO78_RS18230	COG0602	queuosine metabolic process
APECO78_RS18240	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
APECO78_RS18255	COG3956	TIGRFAM MazG family protein
APECO78_RS18260	COG2337	Toxic component of a toxin-antitoxin (TA) module
APECO78_RS18265	COG2336	PFAM SpoVT AbrB
APECO78_RS18270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APECO78_RS18275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APECO78_RS18280	COG4999	Histidine kinase
APECO78_RS18280	COG2205	protein histidine kinase activity
APECO78_RS18280	COG3850	Histidine kinase
APECO78_RS18280	COG3437	response regulator, receiver
APECO78_RS18285	COG4948	Mandelate Racemase Muconate Lactonizing
APECO78_RS18290	COG4948	Mandelate Racemase Muconate Lactonizing
APECO78_RS18295	COG2271	Major facilitator Superfamily
APECO78_RS18300	COG0716	FMN binding
APECO78_RS18305	COG0564	pseudouridine synthase activity
APECO78_RS18310	COG3098	single-species biofilm formation
APECO78_RS18330	COG1611	Belongs to the LOG family
APECO78_RS18335	COG0814	amino acid
APECO78_RS18340	COG1760	l-serine dehydratase
APECO78_RS18350	COG1454	alcohol dehydrogenase
APECO78_RS18355	COG0235	Class ii aldolase
APECO78_RS18360	COG0738	Major facilitator superfamily
APECO78_RS18370	COG1070	Carbohydrate kinase
APECO78_RS18380	COG1349	DNA-binding transcription factor activity
APECO78_RS18390	COG2363	Small membrane protein
APECO78_RS18395	COG0583	DNA-binding transcription factor activity
APECO78_RS18405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APECO78_RS18410	COG2166	iron-sulfur cluster assembly
APECO78_RS18415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
APECO78_RS18420	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
APECO78_RS18440	COG0860	N-Acetylmuramoyl-L-alanine amidase
APECO78_RS18445	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
APECO78_RS18445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APECO78_RS18450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
APECO78_RS18455	COG1074	ATP-dependent DNA helicase activity
APECO78_RS18460	COG1025	Belongs to the peptidase M16 family
APECO78_RS18465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
APECO78_RS18470	COG4967	type IV pilus modification protein PilV
APECO78_RS18480	COG4795	General secretion pathway protein
APECO78_RS18485	COG2165	general secretion pathway protein
APECO78_RS18500	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
APECO78_RS18525	COG0861	Integral membrane protein TerC family
APECO78_RS18535	COG0667	Aldo Keto reductase
APECO78_RS18550	COG1609	Transcriptional regulator
APECO78_RS18560	COG0583	DNA-binding transcription factor activity
APECO78_RS18565	COG1794	racemase activity, acting on amino acids and derivatives
APECO78_RS18570	COG2814	Major facilitator Superfamily
APECO78_RS18575	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS18585	COG0183	Belongs to the thiolase family
APECO78_RS18590	COG0814	amino acid
APECO78_RS18595	COG2771	luxR family
APECO78_RS18600	COG3710	Transcriptional regulator
APECO78_RS18620	COG0457	Tetratricopeptide repeat
APECO78_RS18625	COG0457	Tetratricopeptide repeat
APECO78_RS18625	COG3710	Transcriptional regulator
APECO78_RS18640	COG0457	Tetratricopeptide repeat
APECO78_RS18640	COG3710	Transcriptional regulator
APECO78_RS18655	COG2197	response regulator
APECO78_RS18660	COG2197	response regulator
APECO78_RS18780	COG3387	PFAM Glycoside hydrolase 15-related
APECO78_RS18790	COG4942	peptidase
APECO78_RS18800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APECO78_RS18805	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APECO78_RS18810	COG2080	2 iron, 2 sulfur cluster binding
APECO78_RS18815	COG3829	transcription factor binding
APECO78_RS18820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APECO78_RS18825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APECO78_RS18830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
APECO78_RS18840	COG0549	Belongs to the carbamate kinase family
APECO78_RS18845	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
APECO78_RS18845	COG3608	succinylglutamate desuccinylase aspartoacylase
APECO78_RS18850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APECO78_RS18855	COG2068	MobA-Related Protein
APECO78_RS18860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS18860	COG0493	'glutamate synthase
APECO78_RS18865	COG0402	S-adenosylhomocysteine deaminase activity
APECO78_RS18870	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
APECO78_RS18875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
APECO78_RS18875	COG2080	2 iron, 2 sulfur cluster binding
APECO78_RS18880	COG2233	PERMEase
APECO78_RS18885	COG0402	S-adenosylhomocysteine deaminase activity
APECO78_RS18890	COG2252	PERMEase
APECO78_RS18895	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS18900	COG0493	'glutamate synthase
APECO78_RS18900	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS18910	COG2233	PERMEase
APECO78_RS18935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APECO78_RS18940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APECO78_RS18945	COG4974	Belongs to the 'phage' integrase family
APECO78_RS18950	COG0716	FMN binding
APECO78_RS18960	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
APECO78_RS18970	COG1272	protein, Hemolysin III
APECO78_RS18980	COG2723	6-phospho-beta-galactosidase activity
APECO78_RS18985	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS19005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APECO78_RS19010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APECO78_RS19015	COG0006	proline dipeptidase activity
APECO78_RS19030	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APECO78_RS19040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APECO78_RS19060	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APECO78_RS19060	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
APECO78_RS19065	COG1703	isobutyryl-CoA mutase activity
APECO78_RS19070	COG1024	Enoyl-CoA hydratase
APECO78_RS19075	COG0427	acetyl-CoA hydrolase
APECO78_RS19080	COG0583	DNA-binding transcription factor activity
APECO78_RS19085	COG2968	Membrane
APECO78_RS19095	COG0668	transmembrane transport
APECO78_RS19100	COG0191	fructose-bisphosphate aldolase activity
APECO78_RS19130	COG1122	ATPase activity
APECO78_RS19135	COG1122	ATPase activity
APECO78_RS19140	COG1072	(Pantothenic acid kinase))
APECO78_RS19150	COG1494	fructose-1,6-bisphosphatase
APECO78_RS19155	COG1063	alcohol dehydrogenase
APECO78_RS19160	COG2213	PTS system mannitol-specific
APECO78_RS19165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS19170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APECO78_RS19175	COG0501	Belongs to the peptidase M48B family
APECO78_RS19190	COG1166	arginine decarboxylase activity
APECO78_RS19215	COG2814	Major facilitator Superfamily
APECO78_RS19225	COG2356	endonuclease I
APECO78_RS19230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APECO78_RS19235	COG0189	ligase activity
APECO78_RS19250	COG2805	Type II/IV secretion system protein
APECO78_RS19255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APECO78_RS19260	COG0762	integral membrane protein
APECO78_RS19275	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APECO78_RS19285	COG0252	asparaginase activity
APECO78_RS19300	COG3171	Protein conserved in bacteria
APECO78_RS19310	COG1194	a g-specific adenine glycosylase
APECO78_RS19325	COG2211	Major facilitator Superfamily
APECO78_RS19330	COG1982	Orn Lys Arg decarboxylase major
APECO78_RS19335	COG1811	Na channel or pump
APECO78_RS19345	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
APECO78_RS19375	COG2165	general secretion pathway protein
APECO78_RS19385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APECO78_RS19395	COG1620	l-lactate permease
APECO78_RS19400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
APECO78_RS19405	COG3193	protein, possibly involved in utilization of glycolate and propanediol
APECO78_RS19410	COG0247	lactate metabolic process
APECO78_RS19415	COG0277	FAD linked oxidase domain protein
APECO78_RS19420	COG0277	FAD linked oxidase domain protein
APECO78_RS19425	COG2186	Transcriptional regulator
APECO78_RS19430	COG0456	acetyltransferase
APECO78_RS19435	COG0318	PFAM AMP-dependent synthetase and ligase
APECO78_RS19445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APECO78_RS19450	COG0156	8-amino-7-oxononanoate synthase activity
APECO78_RS19460	COG0795	lipopolysaccharide-transporting ATPase activity
APECO78_RS19465	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
APECO78_RS19475	COG2244	polysaccharide biosynthetic process
APECO78_RS19480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APECO78_RS19485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APECO78_RS19490	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APECO78_RS19495	COG0306	phosphate transporter
APECO78_RS19500	COG0754	glutathionylspermidine amidase activity
APECO78_RS19505	COG0625	glutathione transferase activity
APECO78_RS19510	COG0298	carbon dioxide binding
APECO78_RS19520	COG1773	rubredoxin
APECO78_RS19525	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
APECO78_RS19530	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
APECO78_RS19535	COG5557	Pfam Polysulphide reductase, NrfD
APECO78_RS19540	COG0437	4 iron, 4 sulfur cluster binding
APECO78_RS19545	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
APECO78_RS19565	COG0667	Aldo Keto reductase
APECO78_RS19575	COG1028	Short-chain dehydrogenase reductase Sdr
APECO78_RS19580	COG0848	biopolymer transport protein
APECO78_RS19585	COG0811	peptide transport
APECO78_RS19595	COG0626	cystathionine gamma-synthase activity
APECO78_RS19600	COG0586	Pfam SNARE associated Golgi protein
APECO78_RS19605	COG2207	Transcriptional regulator
APECO78_RS19615	COG1979	alcohol dehydrogenase
APECO78_RS19620	COG0656	L-ascorbic acid biosynthetic process
APECO78_RS19630	COG4238	major outer membrane lipoprotein
APECO78_RS19635	COG1032	radical SAM domain protein
APECO78_RS19640	COG2132	Multicopper oxidase
APECO78_RS19645	COG0204	Acyl-transferase
APECO78_RS19650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APECO78_RS19655	COG4166	transmembrane transport
APECO78_RS19660	COG2944	sequence-specific DNA binding
APECO78_RS19670	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
APECO78_RS19675	COG3111	PFAM Bacterial OB fold (BOF) protein
APECO78_RS19680	COG0745	RESPONSE REGULATOR receiver
APECO78_RS19685	COG0642	Histidine kinase
APECO78_RS19690	COG2249	NAD(P)H dehydrogenase (quinone) activity
APECO78_RS19695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
APECO78_RS19720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO78_RS19740	COG0187	DNA topoisomerase II activity
APECO78_RS19745	COG3150	esterase
APECO78_RS19750	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APECO78_RS19755	COG3151	Protein conserved in bacteria
APECO78_RS19760	COG0494	nUDIX hydrolase
APECO78_RS19765	COG1538	Outer membrane efflux protein
APECO78_RS19780	COG0754	glutathionylspermidine amidase activity
APECO78_RS19785	COG3384	dioxygenase
APECO78_RS19805	COG2960	long-chain fatty acid transporting porin activity
APECO78_RS19810	COG3539	Fimbrial protein
APECO78_RS19815	COG3188	usher protein
APECO78_RS19820	COG3121	Chaperone
APECO78_RS19825	COG3539	Fimbrial protein
APECO78_RS19835	COG1585	Membrane protein implicated in regulation of membrane protease activity
APECO78_RS19840	COG2268	Band 7 protein
APECO78_RS19865	COG3025	triphosphatase activity
APECO78_RS19875	COG4991	sh3 domain protein
APECO78_RS19890	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APECO78_RS19900	COG0583	DNA-binding transcription factor activity
APECO78_RS19905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO78_RS19910	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
APECO78_RS19915	COG0471	metal ion transport
APECO78_RS19925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APECO78_RS19930	COG0358	DNA primase activity
APECO78_RS19935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APECO78_RS19950	COG2375	cellular response to nickel ion
APECO78_RS19955	COG1695	Transcriptional regulator
APECO78_RS19960	COG0840	transmembrane signaling receptor activity
APECO78_RS19970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APECO78_RS19975	COG1609	Transcriptional regulator
APECO78_RS19980	COG3250	beta-galactosidase activity
APECO78_RS19985	COG2731	YhcH YjgK YiaL family protein
APECO78_RS19990	COG0531	amino acid
APECO78_RS20000	COG3408	Glycogen debranching enzyme
APECO78_RS20000	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
APECO78_RS20005	COG1902	pentaerythritol trinitrate reductase activity
APECO78_RS20005	COG0446	pyridine nucleotide-disulphide oxidoreductase
APECO78_RS20010	COG5499	transcription regulator containing HTH domain
APECO78_RS20015	COG4680	protein conserved in bacteria
APECO78_RS20025	COG1451	nucleotide metabolic process
APECO78_RS20030	COG2949	membrane
APECO78_RS20035	COG0673	inositol 2-dehydrogenase activity
APECO78_RS20040	COG0861	Integral membrane protein TerC family
APECO78_RS20045	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
APECO78_RS20055	COG2721	sulfolactate sulfo-lyase activity
APECO78_RS20065	COG2271	Major facilitator Superfamily
APECO78_RS20105	COG2186	Transcriptional regulator
APECO78_RS20110	COG0586	Pfam SNARE associated Golgi protein
APECO78_RS20120	COG1422	Protein of unknown function (DUF1090)
APECO78_RS20125	COG4575	ribosome binding
APECO78_RS20130	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
APECO78_RS20140	COG2259	Doxx family
APECO78_RS20145	COG0435	Glutathione S-transferase
APECO78_RS20150	COG3152	Membrane
APECO78_RS20155	COG3152	Membrane
APECO78_RS20160	COG0583	DNA-binding transcription factor activity
APECO78_RS20165	COG1741	Belongs to the pirin family
APECO78_RS20180	COG0814	amino acid
APECO78_RS20185	COG1760	l-serine dehydratase
APECO78_RS20190	COG0251	oxidation-reduction process
APECO78_RS20195	COG1882	Formate acetyltransferase
APECO78_RS20200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APECO78_RS20210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APECO78_RS20215	COG0583	DNA-binding transcription factor activity
APECO78_RS20235	COG1929	Belongs to the glycerate kinase type-1 family
APECO78_RS20240	COG2084	Dehydrogenase
APECO78_RS20250	COG2271	Major facilitator Superfamily
APECO78_RS20255	COG2721	sulfolactate sulfo-lyase activity
APECO78_RS20260	COG2002	toxin-antitoxin pair type II binding
APECO78_RS20270	COG1349	DNA-binding transcription factor activity
APECO78_RS20280	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO78_RS20290	COG3716	PTS system mannose fructose sorbose family IID component
APECO78_RS20295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS20300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APECO78_RS20305	COG2222	sugar isomerase
APECO78_RS20315	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO78_RS20320	COG3715	PTS system
APECO78_RS20325	COG3716	PTS system mannose fructose sorbose family IID component
APECO78_RS20330	COG0363	glucosamine-6-phosphate deaminase activity
APECO78_RS20335	COG3539	Fimbrial protein
APECO78_RS20340	COG3121	Chaperone
APECO78_RS20345	COG3188	usher protein
APECO78_RS20350	COG3539	Fimbrial protein
APECO78_RS20355	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APECO78_RS20375	COG2823	Periplasmic or secreted lipoprotein
APECO78_RS20380	COG0701	Predicted permease
APECO78_RS20385	COG0702	epimerase
APECO78_RS20390	COG0693	protein deglycase activity
APECO78_RS20405	COG3153	acetyltransferase
APECO78_RS20410	COG3154	lipid carrier protein
APECO78_RS20415	COG0826	peptidase U32
APECO78_RS20420	COG0826	peptidase U32
APECO78_RS20425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
APECO78_RS20430	COG0814	amino acid
APECO78_RS20440	COG0513	Belongs to the DEAD box helicase family
APECO78_RS20475	COG0195	Participates in both transcription termination and antitermination
APECO78_RS20495	COG2194	sulfuric ester hydrolase activity
APECO78_RS20505	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APECO78_RS20515	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APECO78_RS20520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APECO78_RS20530	COG1534	Rna-binding protein
APECO78_RS20535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APECO78_RS20540	COG2027	D-alanyl-D-alanine carboxypeptidase
APECO78_RS20550	COG0697	spore germination
APECO78_RS20565	COG0142	geranyltranstransferase activity
APECO78_RS20570	COG3423	Transcriptional regulator
APECO78_RS20580	COG5007	Belongs to the BolA IbaG family
APECO78_RS20585	COG3113	response to antibiotic
APECO78_RS20590	COG2854	intermembrane phospholipid transfer
APECO78_RS20595	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
APECO78_RS20600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APECO78_RS20605	COG1127	ABC transporter
APECO78_RS20610	COG0530	calcium, potassium:sodium antiporter activity
APECO78_RS20615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
APECO78_RS20615	COG0517	IMP dehydrogenase activity
APECO78_RS20620	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
APECO78_RS20625	COG3117	lipopolysaccharide transmembrane transporter activity
APECO78_RS20630	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
APECO78_RS20635	COG1137	ATPase activity
APECO78_RS20640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
APECO78_RS20645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APECO78_RS20660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS20665	COG0515	serine threonine protein kinase
APECO78_RS20675	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
APECO78_RS20680	COG0784	Response regulator, receiver
APECO78_RS20680	COG2198	Histidine kinase
APECO78_RS20680	COG5002	protein histidine kinase activity
APECO78_RS20685	COG1242	4 iron, 4 sulfur cluster binding
APECO78_RS20690	COG0070	glutamate synthase
APECO78_RS20690	COG0069	glutamate synthase activity
APECO78_RS20690	COG0067	glutamate synthase
APECO78_RS20695	COG0493	'glutamate synthase
APECO78_RS20700	COG4804	nuclease activity
APECO78_RS20705	COG2731	YhcH YjgK YiaL family protein
APECO78_RS20735	COG3069	C4-dicarboxylate transmembrane transporter activity
APECO78_RS20740	COG2969	positive regulation of protein catabolic process
APECO78_RS20745	COG0625	glutathione transferase activity
APECO78_RS20760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
APECO78_RS20765	COG3105	Protein conserved in bacteria
APECO78_RS20770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APECO78_RS20775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APECO78_RS20795	COG2732	(Barnase) inhibitor
APECO78_RS20815	COG0583	DNA-binding transcription factor activity
APECO78_RS20820	COG0312	modulator of DNA gyrase
APECO78_RS20825	COG3164	Protein of unknown function
APECO78_RS20830	COG1530	ribonuclease E activity
APECO78_RS20840	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
APECO78_RS20845	COG1792	Involved in formation and maintenance of cell shape
APECO78_RS20850	COG1077	Cell shape determining protein MreB Mrl
APECO78_RS20860	COG2200	EAL domain
APECO78_RS20860	COG2199	diguanylate cyclase activity
APECO78_RS20865	COG0604	alcohol dehydrogenase
APECO78_RS20885	COG0511	ligase activity, forming carbon-carbon bonds
APECO78_RS20890	COG0439	Biotin carboxylase
APECO78_RS20895	COG3924	membrane
APECO78_RS20900	COG4145	pantothenate transmembrane transporter activity
APECO78_RS20910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APECO78_RS20920	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APECO78_RS20930	COG1309	transcriptional regulator
APECO78_RS20935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO78_RS20940	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO78_RS20955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APECO78_RS20960	COG4597	amino acid ABC transporter
APECO78_RS20965	COG0765	amino acid transport
APECO78_RS20970	COG1126	abc transporter atp-binding protein
APECO78_RS21010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APECO78_RS21030	COG0551	DNA topoisomerase type I activity
APECO78_RS21040	COG0758	DNA mediated transformation
APECO78_RS21060	COG0569	domain protein
APECO78_RS21070	COG3036	rescue of stalled ribosome
APECO78_RS21075	COG0789	Transcriptional regulator
APECO78_RS21115	COG0201	protein transport
APECO78_RS21205	COG0089	rRNA binding
APECO78_RS21230	COG3267	Type II secretory pathway component ExeA
APECO78_RS21230	COG3409	Peptidoglycan-binding domain 1 protein
APECO78_RS21235	COG3031	protein transport across the cell outer membrane
APECO78_RS21240	COG1450	Type ii and iii secretion system protein
APECO78_RS21245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APECO78_RS21250	COG1459	type II secretion system
APECO78_RS21255	COG2165	general secretion pathway protein
APECO78_RS21260	COG2165	general secretion pathway protein
APECO78_RS21265	COG2165	general secretion pathway protein
APECO78_RS21270	COG4795	General secretion pathway protein
APECO78_RS21275	COG3156	type II secretion system protein K
APECO78_RS21280	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
APECO78_RS21285	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
APECO78_RS21290	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APECO78_RS21295	COG2193	ferroxidase activity
APECO78_RS21300	COG2906	2 iron, 2 sulfur cluster binding
APECO78_RS21305	COG3979	chitinase
APECO78_RS21345	COG2964	Protein conserved in bacteria
APECO78_RS21350	COG0545	Peptidyl-prolyl cis-trans isomerase
APECO78_RS21360	COG1047	Peptidyl-prolyl cis-trans
APECO78_RS21365	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
APECO78_RS21380	COG0488	(ABC) transporter
APECO78_RS21385	COG0429	hydrolase of the alpha beta-hydrolase fold
APECO78_RS21395	COG3954	Phosphoribulokinase
APECO78_RS21400	COG1765	OsmC-like protein
APECO78_RS21410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APECO78_RS21415	COG1289	transmembrane transporter activity
APECO78_RS21420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APECO78_RS21425	COG0512	Glutamine amidotransferase of anthranilate synthase
APECO78_RS21430	COG2184	nucleotidyltransferase activity
APECO78_RS21440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APECO78_RS21450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APECO78_RS21455	COG2146	nitrite reductase [NAD(P)H] activity
APECO78_RS21460	COG2116	formate transmembrane transporter activity
APECO78_RS21475	COG0531	amino acid
APECO78_RS21480	COG2222	sugar isomerase
APECO78_RS21485	COG1082	Xylose isomerase domain protein TIM barrel
APECO78_RS21495	COG2188	Transcriptional regulator
APECO78_RS21500	COG0626	cystathionine gamma-synthase activity
APECO78_RS21515	COG1735	metal-dependent hydrolase with the TIM-barrel fold
APECO78_RS21520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
APECO78_RS21525	COG3457	Alanine racemase
APECO78_RS21535	COG2188	Transcriptional regulator
APECO78_RS21540	COG0180	Tryptophanyl-tRNA synthetase
APECO78_RS21545	COG0546	phosphoglycolate phosphatase activity
APECO78_RS21550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APECO78_RS21555	COG0338	D12 class N6 adenine-specific DNA methyltransferase
APECO78_RS21560	COG3266	domain, Protein
APECO78_RS21575	COG4796	Type ii and iii secretion system protein
APECO78_RS21590	COG3166	PFAM Fimbrial assembly family protein
APECO78_RS21595	COG4972	Pilus assembly protein
APECO78_RS21600	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APECO78_RS21605	COG0494	nUDIX hydrolase
APECO78_RS21615	COG1011	Hydrolase
APECO78_RS21620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
APECO78_RS21630	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
APECO78_RS21655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
APECO78_RS21660	COG2183	response to ionizing radiation
APECO78_RS21665	COG1918	ferrous iron import across plasma membrane
APECO78_RS21670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
APECO78_RS21680	COG5464	transposase or invertase
APECO78_RS21700	COG2610	gluconate transmembrane transporter activity
APECO78_RS21705	COG1640	4-alpha-glucanotransferase
APECO78_RS21710	COG0058	SHG alpha-glucan phosphorylase activity
APECO78_RS21725	COG1690	Belongs to the RtcB family
APECO78_RS21730	COG4650	regulator
APECO78_RS21735	COG1349	DNA-binding transcription factor activity
APECO78_RS21750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APECO78_RS21770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APECO78_RS21775	COG0058	SHG alpha-glucan phosphorylase activity
APECO78_RS21800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APECO78_RS21805	COG2095	MarC family integral membrane protein
APECO78_RS21810	COG2610	gluconate transmembrane transporter activity
APECO78_RS21815	COG3265	gluconokinase activity
APECO78_RS21820	COG1609	Transcriptional regulator
APECO78_RS21825	COG1741	Belongs to the pirin family
APECO78_RS21830	COG0673	inositol 2-dehydrogenase activity
APECO78_RS21835	COG1247	-acetyltransferase
APECO78_RS21845	COG0405	Gamma-glutamyltransferase
APECO78_RS21855	COG0584	glycerophosphoryl diester phosphodiesterase
APECO78_RS21865	COG0395	ABC-type sugar transport system, permease component
APECO78_RS21870	COG1175	transmembrane transport
APECO78_RS21875	COG1653	transport
APECO78_RS21885	COG0410	ABC transporter
APECO78_RS21890	COG0411	ABC transporter
APECO78_RS21895	COG4177	L-phenylalanine transmembrane transporter activity
APECO78_RS21900	COG0559	Belongs to the binding-protein-dependent transport system permease family
APECO78_RS21905	COG0683	leucine binding
APECO78_RS21910	COG0456	acetyltransferase
APECO78_RS21925	COG0683	leucine binding
APECO78_RS21930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APECO78_RS21935	COG2177	Part of the ABC transporter FtsEX involved in
APECO78_RS21940	COG2884	Cell division ATP-binding protein ftsE
APECO78_RS21945	COG0552	protein localization to endoplasmic reticulum
APECO78_RS21950	COG0742	ribosomal rna small subunit methyltransferase
APECO78_RS21955	COG3776	membrane
APECO78_RS21965	COG3714	YhhN family
APECO78_RS21980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
APECO78_RS21995	COG0628	permease
APECO78_RS22000	COG2091	lysine biosynthetic process via aminoadipic acid
APECO78_RS22005	COG0747	negative chemotaxis
APECO78_RS22010	COG0601	transmembrane transport
APECO78_RS22015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APECO78_RS22020	COG0444	Belongs to the ABC transporter superfamily
APECO78_RS22045	COG0842	Transport permease protein
APECO78_RS22050	COG1129	ABC transporter
APECO78_RS22050	COG0842	Transport permease protein
APECO78_RS22055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO78_RS22085	COG2081	HI0933 family
APECO78_RS22090	COG0306	phosphate transporter
APECO78_RS22100	COG0589	response to stress
APECO78_RS22105	COG3104	oligopeptide transport
APECO78_RS22115	COG0339	signal peptide processing
APECO78_RS22120	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
APECO78_RS22125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APECO78_RS22140	COG0640	Transcriptional regulator
APECO78_RS22145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
APECO78_RS22150	COG1393	Belongs to the ArsC family
APECO78_RS22160	COG3065	identical protein binding
APECO78_RS22165	COG2197	response regulator
APECO78_RS22170	COG1285	pathogenesis
APECO78_RS22185	COG3247	response to pH
APECO78_RS22190	COG2771	luxR family
APECO78_RS22200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APECO78_RS22205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APECO78_RS22210	COG2207	Transcriptional regulator
APECO78_RS22220	COG0076	glutamate decarboxylase activity
APECO78_RS22225	COG1858	cytochrome C peroxidase
APECO78_RS22235	COG2197	response regulator
APECO78_RS22240	COG0583	DNA-binding transcription factor activity
APECO78_RS22245	COG1295	ribonuclease BN
APECO78_RS22250	COG0477	Major facilitator Superfamily
APECO78_RS22255	COG2982	Protein involved in outer membrane biogenesis
APECO78_RS22260	COG2200	EAL domain
APECO78_RS22275	COG0612	Peptidase, M16
APECO78_RS22285	COG2200	EAL domain
APECO78_RS22285	COG2199	diguanylate cyclase activity
APECO78_RS22290	COG0457	Tetratricopeptide repeat
APECO78_RS22290	COG3118	belongs to the thioredoxin family
APECO78_RS22295	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
APECO78_RS22300	COG1215	transferase activity, transferring glycosyl groups
APECO78_RS22305	COG1215	transferase activity, transferring glycosyl groups
APECO78_RS22330	COG2194	sulfuric ester hydrolase activity
APECO78_RS22360	COG0814	amino acid
APECO78_RS22365	COG4608	Belongs to the ABC transporter superfamily
APECO78_RS22370	COG0444	Belongs to the ABC transporter superfamily
APECO78_RS22375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APECO78_RS22380	COG0601	transmembrane transport
APECO78_RS22390	COG0747	negative chemotaxis
APECO78_RS22400	COG2194	sulfuric ester hydrolase activity
APECO78_RS22405	COG2223	nitrite transmembrane transporter activity
APECO78_RS22410	COG5571	outer membrane autotransporter
APECO78_RS22415	COG2818	Glycosylase
APECO78_RS22420	COG0456	acetyltransferase
APECO78_RS22425	COG0243	molybdopterin cofactor binding
APECO78_RS22430	COG2885	chlorophyll binding
APECO78_RS22445	COG2944	sequence-specific DNA binding
APECO78_RS22450	COG1278	Cold shock
APECO78_RS22475	COG3274	enterobacterial common antigen metabolic process
APECO78_RS22480	COG4682	membrane
APECO78_RS22485	COG4682	membrane
APECO78_RS22490	COG1070	Carbohydrate kinase
APECO78_RS22500	COG4213	ABC transporter substrate-binding protein
APECO78_RS22505	COG1129	ABC transporter
APECO78_RS22510	COG4214	carbohydrate transport
APECO78_RS22515	COG2207	Transcriptional regulator
APECO78_RS22515	COG1609	Transcriptional regulator
APECO78_RS22520	COG2992	FlgJ-related protein
APECO78_RS22525	COG0366	Alpha amylase catalytic
APECO78_RS22530	COG3977	Valine--pyruvate aminotransferase
APECO78_RS22540	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
APECO78_RS22545	COG1414	Transcriptional regulator
APECO78_RS22555	COG2731	YhcH YjgK YiaL family protein
APECO78_RS22560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
APECO78_RS22565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APECO78_RS22570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
APECO78_RS22575	COG1070	Carbohydrate kinase
APECO78_RS22580	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
APECO78_RS22585	COG3623	hexulose-6-phosphate isomerase
APECO78_RS22590	COG0235	Class ii aldolase
APECO78_RS22595	COG3713	MltA-interacting MipA family protein
APECO78_RS22600	COG0583	DNA-binding transcription factor activity
APECO78_RS22605	COG1566	PFAM secretion protein HlyD family protein
APECO78_RS22620	COG1012	belongs to the aldehyde dehydrogenase family
APECO78_RS22625	COG1454	alcohol dehydrogenase
APECO78_RS22630	COG3276	selenocysteine insertion sequence binding
APECO78_RS22640	COG0625	glutathione transferase activity
APECO78_RS22650	COG1413	lyase activity
APECO78_RS22655	COG3209	COG3209 Rhs family protein
APECO78_RS22660	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
APECO78_RS22670	COG1566	PFAM secretion protein HlyD family protein
APECO78_RS22680	COG2213	PTS system mannitol-specific
APECO78_RS22680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
APECO78_RS22690	COG3722	fumarate hydratase activity
APECO78_RS22710	COG5295	Hep Hag repeat protein
APECO78_RS22715	COG1620	l-lactate permease
APECO78_RS22720	COG2186	Transcriptional regulator
APECO78_RS22730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APECO78_RS22735	COG1045	serine acetyltransferase
APECO78_RS22750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APECO78_RS22755	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APECO78_RS22765	COG4942	peptidase
APECO78_RS22770	COG2861	carbohydrate metabolic process
APECO78_RS22775	COG1216	Glycosyl transferase, family 2
APECO78_RS22785	COG0156	8-amino-7-oxononanoate synthase activity
APECO78_RS22795	COG0859	PFAM glycosyl transferase family 9
APECO78_RS22800	COG0859	PFAM glycosyl transferase family 9
APECO78_RS22805	COG3307	-O-antigen
APECO78_RS22810	COG1216	Glycosyl transferase, family 2
APECO78_RS22815	COG1442	glycosyl transferase family 8
APECO78_RS22820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APECO78_RS22835	COG0515	serine threonine protein kinase
APECO78_RS22840	COG0438	transferase activity, transferring glycosyl groups
APECO78_RS22845	COG0859	PFAM glycosyl transferase family 9
APECO78_RS22850	COG1519	Transferase
APECO78_RS22880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APECO78_RS22910	COG1561	YicC-like family, N-terminal region
APECO78_RS22915	COG3645	SOS response
APECO78_RS22920	COG2860	membrane
APECO78_RS22935	COG0194	GDP metabolic process
APECO78_RS22945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APECO78_RS22950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APECO78_RS22955	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APECO78_RS22965	COG0786	glutamate:sodium symporter activity
APECO78_RS22970	COG2233	PERMEase
APECO78_RS22975	COG2982	Protein involved in outer membrane biogenesis
APECO78_RS22980	COG1501	Belongs to the glycosyl hydrolase 31 family
APECO78_RS22985	COG2211	Major facilitator Superfamily
APECO78_RS23000	COG2814	Major facilitator Superfamily
APECO78_RS23005	COG0697	spore germination
APECO78_RS23010	COG1464	Belongs to the NlpA lipoprotein family
APECO78_RS23035	COG2252	PERMEase
APECO78_RS23045	COG2271	Major facilitator Superfamily
APECO78_RS23050	COG2271	Major facilitator Superfamily
APECO78_RS23055	COG3851	Histidine kinase
APECO78_RS23060	COG2197	response regulator
APECO78_RS23065	COG0440	acetolactate synthase activity
APECO78_RS23070	COG0028	Belongs to the TPP enzyme family
APECO78_RS23095	COG2814	Major facilitator Superfamily
APECO78_RS23100	COG0641	radical SAM
APECO78_RS23110	COG2149	membrane
APECO78_RS23120	COG3119	arylsulfatase activity
APECO78_RS23125	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
APECO78_RS23130	COG2207	Transcriptional regulator
APECO78_RS23145	COG2188	Transcriptional regulator
APECO78_RS23165	COG5645	(Lipo)protein
APECO78_RS23170	COG0823	Involved in the tonB-independent uptake of proteins
APECO78_RS23180	COG2271	Major facilitator Superfamily
APECO78_RS23190	COG0800	Aldolase
APECO78_RS23195	COG3734	2-keto-3-deoxy-galactonokinase
APECO78_RS23200	COG2186	Transcriptional regulator
APECO78_RS23210	COG0561	phosphatase activity
APECO78_RS23215	COG3753	Protein conserved in bacteria
APECO78_RS23225	COG0187	DNA topoisomerase II activity
APECO78_RS23235	COG0592	DNA-directed DNA polymerase activity
APECO78_RS23280	COG0814	amino acid
APECO78_RS23295	COG2091	lysine biosynthetic process via aminoadipic acid
APECO78_RS23300	COG0431	NADPH-dependent FMN reductase
APECO78_RS23305	COG2252	PERMEase
APECO78_RS23310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APECO78_RS23320	COG3196	Protein conserved in bacteria
APECO78_RS23325	COG0363	glucosamine-6-phosphate deaminase activity
APECO78_RS23330	COG2382	esterase
APECO78_RS23340	COG2723	6-phospho-beta-galactosidase activity
APECO78_RS23345	COG2190	(PTS) system
APECO78_RS23345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
APECO78_RS23345	COG1263	PTS System
APECO78_RS23350	COG3711	transcriptional antiterminator
APECO78_RS23355	COG0704	Plays a role in the regulation of phosphate uptake
APECO78_RS23360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APECO78_RS23365	COG0581	inorganic phosphate transmembrane transporter activity
APECO78_RS23370	COG0573	inorganic phosphate transmembrane transporter activity
APECO78_RS23375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APECO78_RS23385	COG3188	usher protein
APECO78_RS23400	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APECO78_RS23450	COG3312	ion transport
APECO78_RS23465	COG0716	FMN binding
APECO78_RS23470	COG1522	sequence-specific DNA binding
APECO78_RS23505	COG1172	Belongs to the binding-protein-dependent transport system permease family
APECO78_RS23510	COG1879	ABC-type sugar transport system periplasmic component
APECO78_RS23515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APECO78_RS23520	COG1609	Transcriptional regulator
APECO78_RS23525	COG0477	Major facilitator Superfamily
APECO78_RS23530	COG2186	Transcriptional regulator
APECO78_RS23575	COG3085	chromosome segregation
APECO78_RS23580	COG0606	chelatase, subunit chli
APECO78_RS23595	COG3978	acetolactate synthase activity
APECO78_RS23600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APECO78_RS23610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APECO78_RS23615	COG0583	DNA-binding transcription factor activity
APECO78_RS23625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
APECO78_RS23630	COG3692	DNA binding
APECO78_RS23635	COG0210	DNA helicase
APECO78_RS23650	COG3118	belongs to the thioredoxin family
APECO78_RS23660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
APECO78_RS23670	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APECO78_RS23675	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
APECO78_RS23680	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APECO78_RS23685	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
APECO78_RS23690	COG1088	dTDP-glucose 4,6-dehydratase activity
APECO78_RS23695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
APECO78_RS23700	COG0456	acetyltransferase
APECO78_RS23705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
APECO78_RS23710	COG2244	polysaccharide biosynthetic process
APECO78_RS23730	COG1113	amino acid transport
APECO78_RS23755	COG0641	radical SAM
APECO78_RS23760	COG3119	arylsulfatase activity
APECO78_RS23765	COG3071	HemY protein
APECO78_RS23770	COG2959	enzyme of heme biosynthesis
APECO78_RS23775	COG1587	Uroporphyrinogen-III synthase
APECO78_RS23785	COG3072	Adenylate cyclase
APECO78_RS23795	COG5567	small periplasmic lipoprotein
APECO78_RS23805	COG3159	Protein conserved in bacteria
APECO78_RS23815	COG1011	Hydrolase
APECO78_RS23820	COG0210	DNA helicase
APECO78_RS23825	COG3698	Phosphodiester glycosidase
APECO78_RS23835	COG0598	Magnesium transport protein CorA
APECO78_RS23850	COG2962	Rard protein
APECO78_RS23855	COG2050	protein possibly involved in aromatic compounds catabolism
APECO78_RS23860	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
APECO78_RS23865	COG0514	ATP-dependent DNA helicase (RecQ)
APECO78_RS23870	COG1280	lysine exporter protein (LysE YggA)
APECO78_RS23875	COG1280	lysine exporter protein (LysE YggA)
APECO78_RS23880	COG2267	carboxylic ester hydrolase activity
APECO78_RS23885	COG0561	phosphatase activity
APECO78_RS23890	COG0697	spore germination
APECO78_RS23895	COG0583	DNA-binding transcription factor activity
APECO78_RS23905	COG0412	Dienelactone hydrolase
APECO78_RS23910	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
APECO78_RS23915	COG1322	Protein conserved in bacteria
APECO78_RS23925	COG3165	ubiquinone biosynthetic process from chorismate
APECO78_RS23935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APECO78_RS23940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APECO78_RS23945	COG0805	protein transport
APECO78_RS23950	COG0084	hydrolase, TatD family'
APECO78_RS23955	COG0250	Participates in transcription elongation, termination and antitermination
APECO78_RS23960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APECO78_RS23965	COG0543	2 iron, 2 sulfur cluster binding
APECO78_RS23985	COG1739	Uncharacterized protein family UPF0029
APECO78_RS23990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APECO78_RS23995	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
APECO78_RS24095	COG3757	hydrolase, family 25