locus-tag	class	description
E0708_RS00015	COG1960	acyl-CoA dehydrogenase activity
E0708_RS00020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0708_RS00025	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0708_RS00040	COG2197	response regulator
E0708_RS00065	COG1376	ErfK ybiS ycfS ynhG family protein
E0708_RS00080	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
E0708_RS00085	COG4771	TonB-dependent receptor
E0708_RS00090	COG1475	DNA binding
E0708_RS00095	COG3969	phosphoadenosine phosphosulfate
E0708_RS00100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E0708_RS00125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS00140	COG1735	metal-dependent hydrolase with the TIM-barrel fold
E0708_RS00175	COG3547	Transposase (IS116 IS110 IS902 family)
E0708_RS00220	COG1120	ATPase activity
E0708_RS00225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0708_RS00280	COG2003	Belongs to the UPF0758 family
E0708_RS00310	COG4372	Transposase
E0708_RS00325	COG1289	transmembrane transporter activity
E0708_RS00345	COG1686	Belongs to the peptidase S11 family
E0708_RS00350	COG2925	Exonuclease
E0708_RS00355	COG0531	amino acid
E0708_RS00365	COG0583	DNA-binding transcription factor activity
E0708_RS00370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0708_RS00375	COG4115	mRNA cleavage
E0708_RS00380	COG2161	toxin-antitoxin pair type II binding
E0708_RS00395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E0708_RS00405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E0708_RS00405	COG0131	Imidazoleglycerol-phosphate dehydratase
E0708_RS00410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E0708_RS00425	COG0140	phosphoribosyl-ATP diphosphatase activity
E0708_RS00425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E0708_RS00430	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E0708_RS00435	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E0708_RS00440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E0708_RS00445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E0708_RS00475	COG1216	Glycosyl transferase, family 2
E0708_RS00490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E0708_RS00500	COG0438	transferase activity, transferring glycosyl groups
E0708_RS00505	COG2327	Polysaccharide pyruvyl transferase
E0708_RS00510	COG2244	polysaccharide biosynthetic process
E0708_RS00515	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E0708_RS00520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E0708_RS00525	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E0708_RS00525	COG0662	Cupin 2, conserved barrel domain protein
E0708_RS00530	COG0297	glycogen (starch) synthase activity
E0708_RS00535	COG1051	belongs to the nudix hydrolase family
E0708_RS00540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0708_RS00545	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E0708_RS00550	COG0110	maltose O-acetyltransferase activity
E0708_RS00555	COG1216	Glycosyl transferase, family 2
E0708_RS00565	COG0438	transferase activity, transferring glycosyl groups
E0708_RS00570	COG1045	serine acetyltransferase
E0708_RS00575	COG0463	Glycosyl transferase, family 2
E0708_RS00580	COG3206	protein involved in exopolysaccharide biosynthesis
E0708_RS00580	COG0489	protein tyrosine kinase activity
E0708_RS00585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E0708_RS00590	COG1596	polysaccharide export
E0708_RS00600	COG1253	flavin adenine dinucleotide binding
E0708_RS00605	COG2982	Protein involved in outer membrane biogenesis
E0708_RS00615	COG0572	uridine kinase
E0708_RS00620	COG3447	MASE1 domain protein
E0708_RS00620	COG5001	Diguanylate cyclase
E0708_RS00620	COG5002	protein histidine kinase activity
E0708_RS00625	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
E0708_RS00630	COG0443	Heat shock 70 kDa protein
E0708_RS00635	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
E0708_RS00640	COG0631	protein serine/threonine phosphatase activity
E0708_RS00645	COG4245	von Willebrand factor, type A
E0708_RS00660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0708_RS00670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0708_RS00675	COG2814	Major facilitator Superfamily
E0708_RS00680	COG2205	protein histidine kinase activity
E0708_RS00685	COG0745	RESPONSE REGULATOR receiver
E0708_RS00690	COG3422	double-strand break repair
E0708_RS00725	COG1597	lipid kinase activity
E0708_RS00735	COG1063	alcohol dehydrogenase
E0708_RS00740	COG3775	system Galactitol-specific IIC component
E0708_RS00745	COG3414	Phosphotransferase system galactitol-specific IIB component
E0708_RS00750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS00760	COG0191	fructose-bisphosphate aldolase activity
E0708_RS00765	COG1830	Aldolase
E0708_RS00770	COG2211	Major facilitator Superfamily
E0708_RS00775	COG1397	ADP-ribosylglycohydrolase
E0708_RS00780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS00785	COG2188	Transcriptional regulator
E0708_RS00790	COG3757	hydrolase, family 25
E0708_RS00795	COG0351	phosphomethylpyrimidine kinase
E0708_RS00800	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E0708_RS00815	COG5455	response to cobalt ion
E0708_RS00820	COG3539	Fimbrial protein
E0708_RS00825	COG3188	usher protein
E0708_RS00830	COG3121	Chaperone
E0708_RS00835	COG3539	Fimbrial protein
E0708_RS00845	COG0489	protein tyrosine kinase activity
E0708_RS00855	COG3831	ATPase activity
E0708_RS00860	COG3831	ATPase activity
E0708_RS00870	COG0714	Associated with various cellular activities
E0708_RS00875	COG2425	protein containing a von Willebrand factor type A (vWA) domain
E0708_RS00880	COG3552	Protein containing von Willebrand factor type A (VWA) domain
E0708_RS00885	COG4715	Zinc finger, swim domain protein
E0708_RS00890	COG4808	Protein conserved in bacteria
E0708_RS00895	COG4807	Protein conserved in bacteria
E0708_RS00900	COG3279	Response regulator of the LytR AlgR family
E0708_RS00905	COG3275	phosphorelay sensor kinase activity
E0708_RS00910	COG0789	Transcriptional regulator
E0708_RS00920	COG1174	glycine betaine transport
E0708_RS00925	COG1125	glycine betaine transport
E0708_RS00930	COG1174	glycine betaine transport
E0708_RS00935	COG1732	Glycine betaine
E0708_RS00940	COG1472	Belongs to the glycosyl hydrolase 3 family
E0708_RS00945	COG0277	FAD linked oxidase domain protein
E0708_RS00950	COG1686	Belongs to the peptidase S11 family
E0708_RS00960	COG0586	Pfam SNARE associated Golgi protein
E0708_RS00970	COG1538	Outer membrane efflux protein
E0708_RS00980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E0708_RS00990	COG1346	cytolysis
E0708_RS01000	COG2949	membrane
E0708_RS01010	COG0493	'glutamate synthase
E0708_RS01015	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E0708_RS01015	COG0167	dihydroorotate dehydrogenase activity
E0708_RS01020	COG4211	Belongs to the binding-protein-dependent transport system permease family
E0708_RS01030	COG1879	ABC-type sugar transport system periplasmic component
E0708_RS01035	COG1609	Transcriptional regulator
E0708_RS01040	COG2311	Membrane
E0708_RS01055	COG4771	TonB-dependent receptor
E0708_RS01060	COG0833	amino acid
E0708_RS01065	COG0583	DNA-binding transcription factor activity
E0708_RS01070	COG2855	membrane
E0708_RS01080	COG1522	sequence-specific DNA binding
E0708_RS01080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS01090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0708_RS01095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E0708_RS01100	COG2313	pseudouridylate synthase activity
E0708_RS01105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS01110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS01110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS01110	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E0708_RS01115	COG1105	Belongs to the carbohydrate kinase PfkB family
E0708_RS01120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS01120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS01125	COG2814	Major facilitator Superfamily
E0708_RS01140	COG0246	Mannitol dehydrogenase
E0708_RS01145	COG0523	cobalamin synthesis protein
E0708_RS01150	COG0671	phosphoesterase, PA-phosphatase related
E0708_RS01155	COG0791	NLP P60 protein
E0708_RS01160	COG2200	EAL domain
E0708_RS01165	COG4166	transmembrane transport
E0708_RS01170	COG4174	ABC transporter (Permease)
E0708_RS01175	COG4239	(ABC) transporter, permease
E0708_RS01180	COG4172	Belongs to the ABC transporter superfamily
E0708_RS01190	COG2814	Major facilitator Superfamily
E0708_RS01195	COG1187	pseudouridine synthase activity
E0708_RS01200	COG1061	Type III restriction enzyme res subunit
E0708_RS01220	COG3083	sulfuric ester hydrolase activity
E0708_RS01230	COG0582	viral genome integration into host DNA
E0708_RS01305	COG4220	transposase activity
E0708_RS01320	COG2197	response regulator
E0708_RS01325	COG3088	subunit of a heme lyase
E0708_RS01325	COG4235	cytochrome complex assembly
E0708_RS01330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0708_RS01335	COG1138	Cytochrome C-type biogenesis protein
E0708_RS01345	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0708_RS01350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0708_RS01355	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0708_RS01360	COG4133	protoheme IX ABC transporter activity
E0708_RS01365	COG3005	denitrification pathway
E0708_RS01370	COG3043	anaerobic respiration
E0708_RS01375	COG0348	domain, Protein
E0708_RS01380	COG0437	4 iron, 4 sulfur cluster binding
E0708_RS01390	COG3062	negative regulation of establishment of protein localization
E0708_RS01395	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0708_RS01395	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0708_RS01405	COG0579	oxidoreductase
E0708_RS01410	COG4615	Cyclic peptide transporter
E0708_RS01415	COG3145	DNA-N1-methyladenine dioxygenase activity
E0708_RS01420	COG2169	Transcriptional regulator
E0708_RS01420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E0708_RS01425	COG1477	protein flavinylation
E0708_RS01430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E0708_RS01435	COG0642	Histidine kinase
E0708_RS01435	COG2198	Histidine kinase
E0708_RS01440	COG2197	response regulator
E0708_RS01445	COG2205	protein histidine kinase activity
E0708_RS01445	COG0784	Response regulator, receiver
E0708_RS01450	COG3852	Histidine kinase
E0708_RS01455	COG2204	response regulator
E0708_RS01460	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E0708_RS01465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E0708_RS01470	COG2031	fatty acid transporter
E0708_RS01475	COG0183	Belongs to the thiolase family
E0708_RS01480	COG4676	Protein conserved in bacteria
E0708_RS01485	COG5445	Predicted secreted protein (DUF2300)
E0708_RS01490	COG2373	Large extracellular alpha-helical protein
E0708_RS01495	COG3234	Protein of unknown function (DUF1175)
E0708_RS01500	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
E0708_RS01505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E0708_RS01510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E0708_RS01515	COG3468	outer membrane autotransporter barrel domain protein
E0708_RS01520	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0708_RS01525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0708_RS01530	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E0708_RS01535	COG3642	lipopolysaccharide core region biosynthetic process
E0708_RS01540	COG0584	glycerophosphoryl diester phosphodiesterase
E0708_RS01545	COG2271	Major facilitator Superfamily
E0708_RS01550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E0708_RS01555	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
E0708_RS01560	COG0247	lactate metabolic process
E0708_RS01565	COG5464	transposase or invertase
E0708_RS01575	COG2271	Major facilitator Superfamily
E0708_RS01580	COG4948	Mandelate Racemase Muconate Lactonizing
E0708_RS01585	COG1414	Transcriptional regulator
E0708_RS01620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E0708_RS01620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0708_RS01630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E0708_RS01650	COG0318	PFAM AMP-dependent synthetase and ligase
E0708_RS01655	COG1441	menaquinone biosynthetic process
E0708_RS01660	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E0708_RS01675	COG1169	isochorismate synthase
E0708_RS01680	COG4575	ribosome binding
E0708_RS01685	COG2153	protein acetylation
E0708_RS01695	COG2304	oxidoreductase activity
E0708_RS01700	COG2234	aminopeptidase activity
E0708_RS01715	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0708_RS01720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E0708_RS01730	COG0839	Belongs to the complex I subunit 6 family
E0708_RS01745	COG1034	ATP synthesis coupled electron transport
E0708_RS01750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E0708_RS01755	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E0708_RS01780	COG0436	Aminotransferase
E0708_RS01790	COG0490	domain, Protein
E0708_RS01790	COG0471	metal ion transport
E0708_RS01795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0708_RS01805	COG3092	negative regulation of chromosome organization
E0708_RS01810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E0708_RS01815	COG0857	belongs to the CobB CobQ family
E0708_RS01815	COG0280	phosphate acetyltransferase
E0708_RS01820	COG1288	antiporter activity
E0708_RS01825	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E0708_RS01830	COG0622	Phosphoesterase
E0708_RS01835	COG0625	glutathione transferase activity
E0708_RS01840	COG0625	glutathione transferase activity
E0708_RS01845	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E0708_RS01850	COG1090	epimerase
E0708_RS01855	COG4598	ABC transporter
E0708_RS01860	COG4160	amino acid transport
E0708_RS01865	COG4215	(ABC) transporter
E0708_RS01870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0708_RS01880	COG0163	prenyltransferase activity
E0708_RS01885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E0708_RS01890	COG1286	toxin biosynthetic process
E0708_RS01895	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
E0708_RS01900	COG0285	dihydrofolate synthase activity
E0708_RS01910	COG0586	Pfam SNARE associated Golgi protein
E0708_RS01920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E0708_RS01935	COG2814	Major facilitator Superfamily
E0708_RS01940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0708_RS01945	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E0708_RS01945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0708_RS01955	COG3101	peptidyl-lysine hydroxylation
E0708_RS01960	COG0730	response to heat
E0708_RS01990	COG3539	Fimbrial protein
E0708_RS01995	COG3539	Fimbrial protein
E0708_RS02000	COG3539	Fimbrial protein
E0708_RS02005	COG3121	Chaperone
E0708_RS02010	COG3188	usher protein
E0708_RS02015	COG3539	Fimbrial protein
E0708_RS02020	COG2062	phosphohistidine phosphatase, SixA
E0708_RS02025	COG1024	Enoyl-CoA hydratase
E0708_RS02025	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0708_RS02030	COG0183	Belongs to the thiolase family
E0708_RS02035	COG3691	Protein conserved in bacteria
E0708_RS02040	COG2067	long-chain fatty acid transport protein
E0708_RS02050	COG2116	formate transmembrane transporter activity
E0708_RS02075	COG0582	viral genome integration into host DNA
E0708_RS02080	COG0582	viral genome integration into host DNA
E0708_RS02085	COG0583	DNA-binding transcription factor activity
E0708_RS02090	COG2610	gluconate transmembrane transporter activity
E0708_RS02095	COG3048	D-serine ammonia-lyase activity
E0708_RS02100	COG0477	Major facilitator Superfamily
E0708_RS02105	COG1566	PFAM secretion protein HlyD family protein
E0708_RS02110	COG2197	response regulator
E0708_RS02115	COG2205	protein histidine kinase activity
E0708_RS02115	COG0784	Response regulator, receiver
E0708_RS02115	COG2198	Histidine kinase
E0708_RS02115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0708_RS02120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0708_RS02125	COG0679	Auxin Efflux Carrier
E0708_RS02130	COG0028	Belongs to the TPP enzyme family
E0708_RS02135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0708_RS02155	COG1560	Kdo2-lipid A biosynthetic process
E0708_RS02165	COG0436	Aminotransferase
E0708_RS02170	COG3275	phosphorelay sensor kinase activity
E0708_RS02175	COG3279	Response regulator of the LytR AlgR family
E0708_RS02180	COG2207	Transcriptional regulator
E0708_RS02185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS02185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0708_RS02185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS02190	COG1363	Peptidase, m42
E0708_RS02195	COG0006	proline dipeptidase activity
E0708_RS02200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS02205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS02215	COG0038	chloride channel
E0708_RS02230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E0708_RS02235	COG2199	diguanylate cyclase activity
E0708_RS02235	COG2200	EAL domain
E0708_RS02250	COG3415	Transposase
E0708_RS02255	COG3415	Transposase
E0708_RS02260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0708_RS02285	COG0583	DNA-binding transcription factor activity
E0708_RS02295	COG2211	Major facilitator Superfamily
E0708_RS02300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E0708_RS02310	COG0583	DNA-binding transcription factor activity
E0708_RS02315	COG0385	Bile acid
E0708_RS02320	COG3530	Putative quorum-sensing-regulated virulence factor
E0708_RS02330	COG3115	cell septum assembly
E0708_RS02340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E0708_RS02345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS02350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0708_RS02355	COG2190	(PTS) system
E0708_RS02370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E0708_RS02375	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E0708_RS02380	COG4208	sulfate ABC transporter
E0708_RS02385	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E0708_RS02390	COG4150	thiosulfate binding
E0708_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS02405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS02405	COG1263	PTS System
E0708_RS02410	COG2837	iron assimilation
E0708_RS02430	COG0860	N-Acetylmuramoyl-L-alanine amidase
E0708_RS02440	COG2207	Transcriptional regulator
E0708_RS02445	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E0708_RS02450	COG4816	utilization protein
E0708_RS02460	COG4303	Ethanolamine ammonia lyase large subunit
E0708_RS02465	COG4819	ethanolamine utilization protein
E0708_RS02470	COG3192	ethanolamine utilization protein
E0708_RS02475	COG1454	alcohol dehydrogenase
E0708_RS02480	COG4820	ethanolamine utilization protein (EutJ)
E0708_RS02485	COG1012	belongs to the aldehyde dehydrogenase family
E0708_RS02490	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
E0708_RS02495	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
E0708_RS02500	COG0280	phosphate acetyltransferase
E0708_RS02505	COG4812	Cobalamin adenosyltransferase
E0708_RS02510	COG4766	ethanolamine catabolic process
E0708_RS02515	COG4917	ethanolamine utilization protein
E0708_RS02520	COG4810	utilization protein
E0708_RS02525	COG0280	phosphate acetyltransferase
E0708_RS02525	COG0281	malic enzyme
E0708_RS02530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E0708_RS02535	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E0708_RS02540	COG5342	invasion associated locus B
E0708_RS02550	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0708_RS02550	COG0493	'glutamate synthase
E0708_RS02555	COG3850	Histidine kinase
E0708_RS02560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0708_RS02570	COG1393	Belongs to the ArsC family
E0708_RS02585	COG0400	carboxylic ester hydrolase activity
E0708_RS02595	COG2321	neutral zinc metallopeptidase
E0708_RS02605	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E0708_RS02615	COG2716	regulation of RNA biosynthetic process
E0708_RS02620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E0708_RS02625	COG0628	permease
E0708_RS02630	COG4783	chaperone-mediated protein folding
E0708_RS02635	COG1393	Belongs to the ArsC family
E0708_RS02645	COG2233	PERMEase
E0708_RS02660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E0708_RS02665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E0708_RS02670	COG0248	Ppx GppA phosphatase
E0708_RS02675	COG2200	EAL domain
E0708_RS02690	COG3133	Outer membrane lipoprotein
E0708_RS02705	COG0517	IMP dehydrogenase activity
E0708_RS02705	COG0516	GMP reductase activity
E0708_RS02710	COG1570	exodeoxyribonuclease VII activity
E0708_RS02730	COG1645	bacterial-type flagellum-dependent swarming motility
E0708_RS02745	COG2976	Protein conserved in bacteria
E0708_RS02765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E0708_RS02775	COG4953	penicillin-binding protein 1C
E0708_RS02780	COG2373	Large extracellular alpha-helical protein
E0708_RS02785	COG2897	thiosulfate sulfurtransferase activity
E0708_RS02800	COG2975	iron-sulfur cluster assembly
E0708_RS02805	COG0633	Ferredoxin
E0708_RS02825	COG0822	iron-sulfur transferase activity
E0708_RS02845	COG0483	inositol monophosphate 1-phosphatase activity
E0708_RS02850	COG1073	alpha beta
E0708_RS02855	COG3711	transcriptional antiterminator
E0708_RS02860	COG2814	Major facilitator Superfamily
E0708_RS02865	COG2259	Doxx family
E0708_RS02870	COG2017	converts alpha-aldose to the beta-anomer
E0708_RS02875	COG1063	alcohol dehydrogenase
E0708_RS02880	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0708_RS02885	COG1129	ABC transporter
E0708_RS02890	COG1879	ABC-type sugar transport system periplasmic component
E0708_RS02895	COG0457	Tetratricopeptide repeat
E0708_RS02900	COG1940	carbohydrate kinase activity
E0708_RS02910	COG1017	nitric oxide dioxygenase activity
E0708_RS02910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E0708_RS02915	COG0347	Belongs to the P(II) protein family
E0708_RS02920	COG2204	response regulator
E0708_RS02925	COG3170	Tfp pilus assembly protein FimV
E0708_RS02930	COG2205	protein histidine kinase activity
E0708_RS02935	COG0047	phosphoribosylformylglycinamidine synthase activity
E0708_RS02935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E0708_RS02940	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E0708_RS02945	COG0590	tRNA wobble adenosine to inosine editing
E0708_RS02950	COG0560	Phosphoserine phosphatase
E0708_RS02955	COG1737	Transcriptional regulator
E0708_RS02960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0708_RS02975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E0708_RS02995	COG0681	Belongs to the peptidase S26 family
E0708_RS03005	COG3086	response to oxidative stress
E0708_RS03010	COG3026	antisigma factor binding
E0708_RS03015	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E0708_RS03020	COG1595	DNA-templated transcription, initiation
E0708_RS03030	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E0708_RS03040	COG0513	Belongs to the DEAD box helicase family
E0708_RS03045	COG0583	DNA-binding transcription factor activity
E0708_RS03065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0708_RS03070	COG3118	belongs to the thioredoxin family
E0708_RS03085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E0708_RS03090	COG5544	Lipoprotein
E0708_RS03095	COG0477	Major facilitator Superfamily
E0708_RS03120	COG0542	response to heat
E0708_RS03130	COG0564	pseudouridine synthase activity
E0708_RS03135	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0708_RS03140	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E0708_RS03150	COG1605	Chorismate mutase
E0708_RS03150	COG0077	Prephenate dehydratase
E0708_RS03155	COG1605	Chorismate mutase
E0708_RS03155	COG0287	Prephenate dehydrogenase
E0708_RS03160	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E0708_RS03175	COG2199	diguanylate cyclase activity
E0708_RS03180	COG2885	chlorophyll binding
E0708_RS03205	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E0708_RS03210	COG4137	Cytochrome C assembly protein
E0708_RS03215	COG4536	flavin adenine dinucleotide binding
E0708_RS03230	COG0497	DNA recombination
E0708_RS03235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0708_RS03245	COG2867	negative regulation of translational initiation
E0708_RS03265	COG0579	oxidoreductase
E0708_RS03270	COG1012	belongs to the aldehyde dehydrogenase family
E0708_RS03275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E0708_RS03280	COG1113	amino acid transport
E0708_RS03285	COG1802	Transcriptional regulator
E0708_RS03290	COG1652	LysM domain
E0708_RS03295	COG0401	homolog of Blt101
E0708_RS03300	COG0640	Transcriptional regulator
E0708_RS03305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E0708_RS03310	COG2916	Histone family protein nucleoid-structuring protein H-NS
E0708_RS03325	COG4575	ribosome binding
E0708_RS03330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0708_RS03335	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0708_RS03340	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E0708_RS03350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0708_RS03355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0708_RS03360	COG4175	Glycine betaine
E0708_RS03365	COG4176	ABC-type proline glycine betaine transport system permease component
E0708_RS03370	COG2113	Glycine betaine
E0708_RS03375	COG2814	Major facilitator Superfamily
E0708_RS03380	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E0708_RS03395	COG1846	Transcriptional regulator
E0708_RS03400	COG1566	PFAM secretion protein HlyD family protein
E0708_RS03405	COG2814	Major facilitator Superfamily
E0708_RS03430	COG1238	metal cluster binding
E0708_RS03435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0708_RS03470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
E0708_RS03490	COG1546	Belongs to the CinA family
E0708_RS03495	COG2951	lytic endotransglycosylase activity
E0708_RS03500	COG3730	PTS system glucitol sorbitol-specific
E0708_RS03505	COG3732	PTS system glucitol sorbitol-specific
E0708_RS03515	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS03520	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS03525	COG1349	DNA-binding transcription factor activity
E0708_RS03530	COG0517	IMP dehydrogenase activity
E0708_RS03530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E0708_RS03535	COG3604	Transcriptional regulator
E0708_RS03545	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0708_RS03550	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E0708_RS03555	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0708_RS03565	COG5499	transcription regulator containing HTH domain
E0708_RS03570	COG4680	protein conserved in bacteria
E0708_RS03580	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E0708_RS03590	COG3260	NADH ubiquinone oxidoreductase 20
E0708_RS03595	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0708_RS03600	COG3261	NADH dehydrogenase
E0708_RS03600	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
E0708_RS03605	COG0650	Formate hydrogenlyase subunit 4
E0708_RS03610	COG0651	ATP synthesis coupled electron transport
E0708_RS03615	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0708_RS03625	COG0375	protein maturation
E0708_RS03630	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E0708_RS03635	COG0298	carbon dioxide binding
E0708_RS03640	COG0409	Hydrogenase expression formation protein
E0708_RS03645	COG0309	Hydrogenase expression formation protein (HypE)
E0708_RS03650	COG3604	Transcriptional regulator
E0708_RS03665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E0708_RS03670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E0708_RS03675	COG1349	DNA-binding transcription factor activity
E0708_RS03680	COG2084	Dehydrogenase
E0708_RS03685	COG3395	kinase activity
E0708_RS03690	COG0235	Class ii aldolase
E0708_RS03695	COG3622	Belongs to the hyi family
E0708_RS03700	COG2610	gluconate transmembrane transporter activity
E0708_RS03720	COG1388	LysM domain
E0708_RS03720	COG4942	peptidase
E0708_RS03735	COG0585	pseudouridine synthase activity
E0708_RS03775	COG2234	aminopeptidase activity
E0708_RS03790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E0708_RS03795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E0708_RS03800	COG0720	synthase
E0708_RS03805	COG0644	oxidoreductase
E0708_RS03810	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E0708_RS03815	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E0708_RS03820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E0708_RS03825	COG2086	electron transfer activity
E0708_RS03830	COG0477	Major facilitator Superfamily
E0708_RS03835	COG0277	FAD linked oxidase domain protein
E0708_RS03840	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS03845	COG2223	nitrite transmembrane transporter activity
E0708_RS03850	COG1070	Carbohydrate kinase
E0708_RS03855	COG0602	queuosine metabolic process
E0708_RS03865	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E0708_RS03875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E0708_RS03890	COG3956	TIGRFAM MazG family protein
E0708_RS03895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E0708_RS03905	COG3850	Histidine kinase
E0708_RS03905	COG3437	response regulator, receiver
E0708_RS03905	COG2205	protein histidine kinase activity
E0708_RS03905	COG4999	Histidine kinase
E0708_RS03910	COG4948	Mandelate Racemase Muconate Lactonizing
E0708_RS03915	COG4948	Mandelate Racemase Muconate Lactonizing
E0708_RS03920	COG2271	Major facilitator Superfamily
E0708_RS03925	COG0716	FMN binding
E0708_RS03930	COG0564	pseudouridine synthase activity
E0708_RS03935	COG3098	single-species biofilm formation
E0708_RS03950	COG1611	Belongs to the LOG family
E0708_RS03955	COG0814	amino acid
E0708_RS03960	COG1760	l-serine dehydratase
E0708_RS03970	COG1454	alcohol dehydrogenase
E0708_RS03975	COG0235	Class ii aldolase
E0708_RS03980	COG0738	Major facilitator superfamily
E0708_RS03985	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
E0708_RS03990	COG1070	Carbohydrate kinase
E0708_RS04000	COG1349	DNA-binding transcription factor activity
E0708_RS04010	COG2363	Small membrane protein
E0708_RS04015	COG0583	DNA-binding transcription factor activity
E0708_RS04025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E0708_RS04030	COG2166	iron-sulfur cluster assembly
E0708_RS04035	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E0708_RS04040	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E0708_RS04080	COG2885	chlorophyll binding
E0708_RS04175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E0708_RS04180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS04180	COG1263	PTS System
E0708_RS04185	COG3711	transcriptional antiterminator
E0708_RS04190	COG0860	N-Acetylmuramoyl-L-alanine amidase
E0708_RS04195	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E0708_RS04195	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E0708_RS04200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E0708_RS04205	COG1074	ATP-dependent DNA helicase activity
E0708_RS04210	COG1025	Belongs to the peptidase M16 family
E0708_RS04215	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E0708_RS04220	COG4967	type IV pilus modification protein PilV
E0708_RS04230	COG4795	General secretion pathway protein
E0708_RS04235	COG2165	general secretion pathway protein
E0708_RS04250	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E0708_RS04265	COG0861	Integral membrane protein TerC family
E0708_RS04275	COG0667	Aldo Keto reductase
E0708_RS04290	COG1609	Transcriptional regulator
E0708_RS04300	COG0583	DNA-binding transcription factor activity
E0708_RS04305	COG1794	racemase activity, acting on amino acids and derivatives
E0708_RS04310	COG2814	Major facilitator Superfamily
E0708_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS04325	COG0183	Belongs to the thiolase family
E0708_RS04330	COG0814	amino acid
E0708_RS04340	COG4942	peptidase
E0708_RS04345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E0708_RS04350	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E0708_RS04355	COG2080	2 iron, 2 sulfur cluster binding
E0708_RS04365	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E0708_RS04370	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0708_RS04375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E0708_RS04385	COG0549	Belongs to the carbamate kinase family
E0708_RS04390	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E0708_RS04390	COG3608	succinylglutamate desuccinylase aspartoacylase
E0708_RS04395	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E0708_RS04400	COG2068	MobA-Related Protein
E0708_RS04405	COG0493	'glutamate synthase
E0708_RS04405	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0708_RS04410	COG0402	S-adenosylhomocysteine deaminase activity
E0708_RS04415	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E0708_RS04420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E0708_RS04420	COG2080	2 iron, 2 sulfur cluster binding
E0708_RS04425	COG2233	PERMEase
E0708_RS04430	COG0402	S-adenosylhomocysteine deaminase activity
E0708_RS04435	COG2252	PERMEase
E0708_RS04440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0708_RS04450	COG2233	PERMEase
E0708_RS04465	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
E0708_RS04470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E0708_RS04480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E0708_RS04485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E0708_RS04490	COG4974	Belongs to the 'phage' integrase family
E0708_RS04495	COG0716	FMN binding
E0708_RS04505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E0708_RS04510	COG0354	folic acid binding
E0708_RS04515	COG1272	protein, Hemolysin III
E0708_RS04525	COG2723	6-phospho-beta-galactosidase activity
E0708_RS04530	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E0708_RS04530	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E0708_RS04540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E0708_RS04550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0708_RS04555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0708_RS04560	COG0006	proline dipeptidase activity
E0708_RS04580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E0708_RS04590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0708_RS04610	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E0708_RS04610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E0708_RS04615	COG0583	DNA-binding transcription factor activity
E0708_RS04620	COG2968	Membrane
E0708_RS04625	COG1279	arginine transmembrane transporter activity
E0708_RS04630	COG0668	transmembrane transport
E0708_RS04635	COG0191	fructose-bisphosphate aldolase activity
E0708_RS04670	COG1122	ATPase activity
E0708_RS04675	COG1072	(Pantothenic acid kinase))
E0708_RS04690	COG1063	alcohol dehydrogenase
E0708_RS04695	COG2213	PTS system mannitol-specific
E0708_RS04700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS04705	COG0330	HflC and HflK could
E0708_RS04710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E0708_RS04715	COG0501	Belongs to the peptidase M48B family
E0708_RS04730	COG1166	arginine decarboxylase activity
E0708_RS04750	COG2814	Major facilitator Superfamily
E0708_RS04760	COG2356	endonuclease I
E0708_RS04765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E0708_RS04770	COG0189	ligase activity
E0708_RS04785	COG2805	Type II/IV secretion system protein
E0708_RS04790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E0708_RS04795	COG0762	integral membrane protein
E0708_RS04805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E0708_RS04810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0708_RS04820	COG0252	asparaginase activity
E0708_RS04830	COG3171	Protein conserved in bacteria
E0708_RS04840	COG1194	a g-specific adenine glycosylase
E0708_RS04845	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E0708_RS04855	COG2211	Major facilitator Superfamily
E0708_RS04860	COG1982	Orn Lys Arg decarboxylase major
E0708_RS04865	COG1811	Na channel or pump
E0708_RS04875	COG0582	viral genome integration into host DNA
E0708_RS04895	COG3436	PFAM IS66 Orf2 family protein
E0708_RS04910	COG5002	protein histidine kinase activity
E0708_RS04915	COG0745	RESPONSE REGULATOR receiver
E0708_RS04925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E0708_RS04945	COG2274	protein secretion by the type I secretion system
E0708_RS04965	COG3436	PFAM IS66 Orf2 family protein
E0708_RS05095	COG4771	TonB-dependent receptor
E0708_RS05115	COG3436	PFAM IS66 Orf2 family protein
E0708_RS05180	COG0657	acetylesterase activity
E0708_RS05180	COG2755	lipolytic protein G-D-S-L family
E0708_RS05185	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
E0708_RS05190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E0708_RS05200	COG2814	Major facilitator Superfamily
E0708_RS05205	COG1940	carbohydrate kinase activity
E0708_RS05210	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0708_RS05225	COG3436	PFAM IS66 Orf2 family protein
E0708_RS05235	COG4372	Transposase
E0708_RS05270	COG4983	Phage plasmid primase, P4 family domain protein
E0708_RS05280	COG3468	outer membrane autotransporter barrel domain protein
E0708_RS05295	COG2433	Pfam Transposase IS66
E0708_RS05305	COG3436	PFAM IS66 Orf2 family protein
E0708_RS05315	COG2020	methyltransferase activity
E0708_RS05340	COG2003	Belongs to the UPF0758 family
E0708_RS05400	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E0708_RS05400	COG0517	IMP dehydrogenase activity
E0708_RS05450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E0708_RS05465	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E0708_RS05480	COG3385	transposase activity
E0708_RS05485	COG1620	l-lactate permease
E0708_RS05490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E0708_RS05495	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E0708_RS05500	COG0247	lactate metabolic process
E0708_RS05505	COG0277	FAD linked oxidase domain protein
E0708_RS05510	COG0277	FAD linked oxidase domain protein
E0708_RS05515	COG2186	Transcriptional regulator
E0708_RS05520	COG0456	acetyltransferase
E0708_RS05525	COG0318	PFAM AMP-dependent synthetase and ligase
E0708_RS05535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0708_RS05540	COG0156	8-amino-7-oxononanoate synthase activity
E0708_RS05550	COG0795	lipopolysaccharide-transporting ATPase activity
E0708_RS05555	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E0708_RS05565	COG2244	polysaccharide biosynthetic process
E0708_RS05570	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E0708_RS05575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E0708_RS05580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E0708_RS05585	COG0306	phosphate transporter
E0708_RS05590	COG0754	glutathionylspermidine amidase activity
E0708_RS05595	COG0625	glutathione transferase activity
E0708_RS05600	COG0298	carbon dioxide binding
E0708_RS05605	COG0375	protein maturation
E0708_RS05610	COG1773	rubredoxin
E0708_RS05615	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E0708_RS05620	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E0708_RS05625	COG5557	Pfam Polysulphide reductase, NrfD
E0708_RS05630	COG0437	4 iron, 4 sulfur cluster binding
E0708_RS05635	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E0708_RS05650	COG0667	Aldo Keto reductase
E0708_RS05660	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS05665	COG0848	biopolymer transport protein
E0708_RS05670	COG0811	peptide transport
E0708_RS05675	COG0626	cystathionine gamma-synthase activity
E0708_RS05680	COG0586	Pfam SNARE associated Golgi protein
E0708_RS05685	COG2207	Transcriptional regulator
E0708_RS05690	COG1979	alcohol dehydrogenase
E0708_RS05695	COG0656	L-ascorbic acid biosynthetic process
E0708_RS05705	COG4238	major outer membrane lipoprotein
E0708_RS05710	COG1032	radical SAM domain protein
E0708_RS05715	COG2186	Transcriptional regulator
E0708_RS05720	COG0246	Mannitol dehydrogenase
E0708_RS05725	COG1063	alcohol dehydrogenase
E0708_RS05730	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E0708_RS05750	COG2132	Multicopper oxidase
E0708_RS05755	COG0204	Acyl-transferase
E0708_RS05760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E0708_RS05765	COG4166	transmembrane transport
E0708_RS05770	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E0708_RS05775	COG3111	PFAM Bacterial OB fold (BOF) protein
E0708_RS05780	COG0745	RESPONSE REGULATOR receiver
E0708_RS05785	COG0642	Histidine kinase
E0708_RS05800	COG2249	NAD(P)H dehydrogenase (quinone) activity
E0708_RS05805	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E0708_RS05820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0708_RS05825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0708_RS05830	COG1120	ATPase activity
E0708_RS05835	COG4774	siderophore transport
E0708_RS05840	COG0187	DNA topoisomerase II activity
E0708_RS05850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E0708_RS05855	COG3151	Protein conserved in bacteria
E0708_RS05860	COG0494	nUDIX hydrolase
E0708_RS05865	COG1538	Outer membrane efflux protein
E0708_RS05875	COG0754	glutathionylspermidine amidase activity
E0708_RS05885	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E0708_RS05895	COG3384	dioxygenase
E0708_RS05910	COG3539	Fimbrial protein
E0708_RS05915	COG3188	usher protein
E0708_RS05920	COG3121	Chaperone
E0708_RS05925	COG3539	Fimbrial protein
E0708_RS05945	COG1585	Membrane protein implicated in regulation of membrane protease activity
E0708_RS05950	COG2268	Band 7 protein
E0708_RS05965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E0708_RS05970	COG3025	triphosphatase activity
E0708_RS05980	COG0675	Transposase, IS605 OrfB family
E0708_RS05985	COG4991	sh3 domain protein
E0708_RS05990	COG0617	tRNA 3'-terminal CCA addition
E0708_RS06000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E0708_RS06020	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E0708_RS06035	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E0708_RS06040	COG0358	DNA primase activity
E0708_RS06045	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E0708_RS06060	COG2375	cellular response to nickel ion
E0708_RS06065	COG1695	Transcriptional regulator
E0708_RS06070	COG0840	transmembrane signaling receptor activity
E0708_RS06075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0708_RS06080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0708_RS06085	COG1609	Transcriptional regulator
E0708_RS06090	COG3250	beta-galactosidase activity
E0708_RS06095	COG2731	YhcH YjgK YiaL family protein
E0708_RS06100	COG0531	amino acid
E0708_RS06110	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E0708_RS06110	COG3408	Glycogen debranching enzyme
E0708_RS06115	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0708_RS06115	COG1902	pentaerythritol trinitrate reductase activity
E0708_RS06120	COG5499	transcription regulator containing HTH domain
E0708_RS06135	COG1451	nucleotide metabolic process
E0708_RS06140	COG2949	membrane
E0708_RS06145	COG0673	inositol 2-dehydrogenase activity
E0708_RS06150	COG0861	Integral membrane protein TerC family
E0708_RS06155	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E0708_RS06165	COG2721	sulfolactate sulfo-lyase activity
E0708_RS06175	COG2271	Major facilitator Superfamily
E0708_RS06180	COG2186	Transcriptional regulator
E0708_RS06185	COG0586	Pfam SNARE associated Golgi protein
E0708_RS06195	COG1422	Protein of unknown function (DUF1090)
E0708_RS06200	COG4575	ribosome binding
E0708_RS06205	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
E0708_RS06215	COG2259	Doxx family
E0708_RS06220	COG0435	Glutathione S-transferase
E0708_RS06225	COG3152	Membrane
E0708_RS06230	COG0583	DNA-binding transcription factor activity
E0708_RS06235	COG1741	Belongs to the pirin family
E0708_RS06250	COG0814	amino acid
E0708_RS06255	COG1760	l-serine dehydratase
E0708_RS06260	COG0251	oxidation-reduction process
E0708_RS06265	COG1882	Formate acetyltransferase
E0708_RS06270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E0708_RS06280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0708_RS06285	COG0583	DNA-binding transcription factor activity
E0708_RS06300	COG1929	Belongs to the glycerate kinase type-1 family
E0708_RS06305	COG2084	Dehydrogenase
E0708_RS06310	COG3836	Belongs to the HpcH HpaI aldolase family
E0708_RS06315	COG2271	Major facilitator Superfamily
E0708_RS06320	COG2721	sulfolactate sulfo-lyase activity
E0708_RS06325	COG2002	toxin-antitoxin pair type II binding
E0708_RS06335	COG1349	DNA-binding transcription factor activity
E0708_RS06345	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS06355	COG3716	PTS system mannose fructose sorbose family IID component
E0708_RS06360	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS06365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E0708_RS06370	COG2222	sugar isomerase
E0708_RS06380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS06385	COG3715	PTS system
E0708_RS06390	COG3716	PTS system mannose fructose sorbose family IID component
E0708_RS06395	COG0363	glucosamine-6-phosphate deaminase activity
E0708_RS06400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E0708_RS06405	COG3107	peptidoglycan biosynthetic process
E0708_RS06420	COG2823	Periplasmic or secreted lipoprotein
E0708_RS06425	COG0701	Predicted permease
E0708_RS06430	COG0702	epimerase
E0708_RS06445	COG3153	acetyltransferase
E0708_RS06450	COG3154	lipid carrier protein
E0708_RS06455	COG0826	peptidase U32
E0708_RS06460	COG0826	peptidase U32
E0708_RS06465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E0708_RS06470	COG0814	amino acid
E0708_RS06475	COG0513	Belongs to the DEAD box helicase family
E0708_RS06515	COG0195	Participates in both transcription termination and antitermination
E0708_RS06535	COG2194	sulfuric ester hydrolase activity
E0708_RS06545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E0708_RS06555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E0708_RS06560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0708_RS06570	COG1534	Rna-binding protein
E0708_RS06575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0708_RS06580	COG2027	D-alanyl-D-alanine carboxypeptidase
E0708_RS06590	COG0697	spore germination
E0708_RS06605	COG0142	geranyltranstransferase activity
E0708_RS06610	COG3423	Transcriptional regulator
E0708_RS06620	COG5007	Belongs to the BolA IbaG family
E0708_RS06625	COG3113	response to antibiotic
E0708_RS06630	COG2854	intermembrane phospholipid transfer
E0708_RS06635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E0708_RS06640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E0708_RS06645	COG1127	ABC transporter
E0708_RS06650	COG0530	calcium, potassium:sodium antiporter activity
E0708_RS06655	COG0517	IMP dehydrogenase activity
E0708_RS06655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E0708_RS06660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E0708_RS06665	COG3117	lipopolysaccharide transmembrane transporter activity
E0708_RS06670	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E0708_RS06675	COG1137	ATPase activity
E0708_RS06680	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E0708_RS06685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E0708_RS06700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS06705	COG0515	serine threonine protein kinase
E0708_RS06715	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E0708_RS06720	COG5002	protein histidine kinase activity
E0708_RS06720	COG2198	Histidine kinase
E0708_RS06720	COG0784	Response regulator, receiver
E0708_RS06725	COG1242	4 iron, 4 sulfur cluster binding
E0708_RS06730	COG0067	glutamate synthase
E0708_RS06730	COG0069	glutamate synthase activity
E0708_RS06730	COG0070	glutamate synthase
E0708_RS06735	COG0493	'glutamate synthase
E0708_RS06740	COG2731	YhcH YjgK YiaL family protein
E0708_RS06745	COG1940	carbohydrate kinase activity
E0708_RS06755	COG2814	Major facilitator Superfamily
E0708_RS06770	COG2969	positive regulation of protein catabolic process
E0708_RS06775	COG0625	glutathione transferase activity
E0708_RS06790	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E0708_RS06795	COG3105	Protein conserved in bacteria
E0708_RS06800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0708_RS06805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0708_RS06825	COG2732	(Barnase) inhibitor
E0708_RS06830	COG1289	transmembrane transporter activity
E0708_RS06845	COG0583	DNA-binding transcription factor activity
E0708_RS06850	COG0312	modulator of DNA gyrase
E0708_RS06855	COG3164	Protein of unknown function
E0708_RS06860	COG1530	ribonuclease E activity
E0708_RS06870	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E0708_RS06875	COG1792	Involved in formation and maintenance of cell shape
E0708_RS06880	COG1077	Cell shape determining protein MreB Mrl
E0708_RS06885	COG2199	diguanylate cyclase activity
E0708_RS06885	COG2200	EAL domain
E0708_RS06890	COG0604	alcohol dehydrogenase
E0708_RS06900	COG0511	ligase activity, forming carbon-carbon bonds
E0708_RS06905	COG0439	Biotin carboxylase
E0708_RS06915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS06920	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0708_RS06925	COG1129	ABC transporter
E0708_RS06930	COG1879	ABC-type sugar transport system periplasmic component
E0708_RS06940	COG1349	DNA-binding transcription factor activity
E0708_RS06945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS06950	COG3924	membrane
E0708_RS06955	COG4145	pantothenate transmembrane transporter activity
E0708_RS06965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E0708_RS06975	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E0708_RS06985	COG1309	transcriptional regulator
E0708_RS06990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0708_RS06995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0708_RS07005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0708_RS07010	COG4597	amino acid ABC transporter
E0708_RS07015	COG0765	amino acid transport
E0708_RS07020	COG1126	abc transporter atp-binding protein
E0708_RS07060	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E0708_RS07070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E0708_RS07075	COG0009	L-threonylcarbamoyladenylate synthase
E0708_RS07080	COG0551	DNA topoisomerase type I activity
E0708_RS07090	COG0758	DNA mediated transformation
E0708_RS07100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E0708_RS07105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E0708_RS07105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E0708_RS07110	COG0569	domain protein
E0708_RS07120	COG3036	rescue of stalled ribosome
E0708_RS07125	COG0789	Transcriptional regulator
E0708_RS07165	COG0201	protein transport
E0708_RS07255	COG0089	rRNA binding
E0708_RS07280	COG3267	Type II secretory pathway component ExeA
E0708_RS07280	COG3409	Peptidoglycan-binding domain 1 protein
E0708_RS07285	COG3031	protein transport across the cell outer membrane
E0708_RS07290	COG1450	Type ii and iii secretion system protein
E0708_RS07295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E0708_RS07300	COG1459	type II secretion system
E0708_RS07305	COG2165	general secretion pathway protein
E0708_RS07310	COG2165	general secretion pathway protein
E0708_RS07315	COG2165	general secretion pathway protein
E0708_RS07320	COG4795	General secretion pathway protein
E0708_RS07330	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E0708_RS07335	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E0708_RS07340	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E0708_RS07345	COG2193	ferroxidase activity
E0708_RS07350	COG2906	2 iron, 2 sulfur cluster binding
E0708_RS07355	COG3979	chitinase
E0708_RS07395	COG2964	Protein conserved in bacteria
E0708_RS07400	COG0545	Peptidyl-prolyl cis-trans isomerase
E0708_RS07410	COG1047	Peptidyl-prolyl cis-trans
E0708_RS07415	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E0708_RS07430	COG0488	(ABC) transporter
E0708_RS07435	COG0429	hydrolase of the alpha beta-hydrolase fold
E0708_RS07445	COG3954	Phosphoribulokinase
E0708_RS07450	COG1765	OsmC-like protein
E0708_RS07455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0708_RS07460	COG1289	transmembrane transporter activity
E0708_RS07465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0708_RS07470	COG0512	Glutamine amidotransferase of anthranilate synthase
E0708_RS07475	COG2184	nucleotidyltransferase activity
E0708_RS07485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E0708_RS07495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E0708_RS07500	COG2146	nitrite reductase [NAD(P)H] activity
E0708_RS07505	COG2116	formate transmembrane transporter activity
E0708_RS07520	COG0626	cystathionine gamma-synthase activity
E0708_RS07535	COG1735	metal-dependent hydrolase with the TIM-barrel fold
E0708_RS07540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E0708_RS07545	COG3457	Alanine racemase
E0708_RS07555	COG2188	Transcriptional regulator
E0708_RS07560	COG0180	Tryptophanyl-tRNA synthetase
E0708_RS07565	COG0546	phosphoglycolate phosphatase activity
E0708_RS07570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E0708_RS07575	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E0708_RS07580	COG3266	domain, Protein
E0708_RS07595	COG4796	Type ii and iii secretion system protein
E0708_RS07610	COG3166	PFAM Fimbrial assembly family protein
E0708_RS07615	COG4972	Pilus assembly protein
E0708_RS07620	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E0708_RS07625	COG0494	nUDIX hydrolase
E0708_RS07635	COG1011	Hydrolase
E0708_RS07640	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E0708_RS07650	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E0708_RS07655	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E0708_RS07670	COG2205	protein histidine kinase activity
E0708_RS07675	COG0745	RESPONSE REGULATOR receiver
E0708_RS07680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0708_RS07685	COG2183	response to ionizing radiation
E0708_RS07690	COG1918	ferrous iron import across plasma membrane
E0708_RS07695	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E0708_RS07710	COG0596	Alpha beta hydrolase
E0708_RS07715	COG1040	competence protein
E0708_RS07725	COG2610	gluconate transmembrane transporter activity
E0708_RS07730	COG1640	4-alpha-glucanotransferase
E0708_RS07735	COG0058	SHG alpha-glucan phosphorylase activity
E0708_RS07740	COG2909	trisaccharide binding
E0708_RS07750	COG1690	Belongs to the RtcB family
E0708_RS07755	COG4650	regulator
E0708_RS07760	COG1349	DNA-binding transcription factor activity
E0708_RS07775	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
E0708_RS07815	COG3188	usher protein
E0708_RS07820	COG3121	Chaperone
E0708_RS07830	COG0058	SHG alpha-glucan phosphorylase activity
E0708_RS07845	COG1523	belongs to the glycosyl hydrolase 13 family
E0708_RS07850	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E0708_RS07855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E0708_RS07860	COG2095	MarC family integral membrane protein
E0708_RS07870	COG0514	ATP-dependent DNA helicase (RecQ)
E0708_RS07875	COG2610	gluconate transmembrane transporter activity
E0708_RS07880	COG3265	gluconokinase activity
E0708_RS07885	COG1609	Transcriptional regulator
E0708_RS07890	COG1741	Belongs to the pirin family
E0708_RS07895	COG0673	inositol 2-dehydrogenase activity
E0708_RS07900	COG1247	-acetyltransferase
E0708_RS07905	COG1247	-acetyltransferase
E0708_RS07910	COG3157	Type VI secretion system effector, Hcp
E0708_RS07930	COG0405	Gamma-glutamyltransferase
E0708_RS07940	COG0584	glycerophosphoryl diester phosphodiesterase
E0708_RS07945	COG3842	ATPase activity
E0708_RS07955	COG1175	transmembrane transport
E0708_RS07965	COG0410	ABC transporter
E0708_RS07970	COG0411	ABC transporter
E0708_RS07975	COG4177	L-phenylalanine transmembrane transporter activity
E0708_RS07980	COG0559	Belongs to the binding-protein-dependent transport system permease family
E0708_RS07985	COG0683	leucine binding
E0708_RS07990	COG0456	acetyltransferase
E0708_RS07995	COG0683	leucine binding
E0708_RS08000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E0708_RS08005	COG2177	Part of the ABC transporter FtsEX involved in
E0708_RS08010	COG2884	Cell division ATP-binding protein ftsE
E0708_RS08015	COG0552	protein localization to endoplasmic reticulum
E0708_RS08020	COG0742	ribosomal rna small subunit methyltransferase
E0708_RS08025	COG3776	membrane
E0708_RS08035	COG3714	YhhN family
E0708_RS08050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E0708_RS08060	COG0477	Major facilitator Superfamily
E0708_RS08065	COG0628	permease
E0708_RS08070	COG2091	lysine biosynthetic process via aminoadipic acid
E0708_RS08075	COG0747	negative chemotaxis
E0708_RS08080	COG0601	transmembrane transport
E0708_RS08085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0708_RS08090	COG0444	Belongs to the ABC transporter superfamily
E0708_RS08105	COG2188	Transcriptional regulator
E0708_RS08115	COG3414	Phosphotransferase system galactitol-specific IIB component
E0708_RS08120	COG3775	system Galactitol-specific IIC component
E0708_RS08135	COG0191	fructose-bisphosphate aldolase activity
E0708_RS08140	COG0842	Transport permease protein
E0708_RS08145	COG0842	Transport permease protein
E0708_RS08145	COG1129	ABC transporter
E0708_RS08150	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0708_RS08160	COG2081	HI0933 family
E0708_RS08165	COG0306	phosphate transporter
E0708_RS08175	COG0589	response to stress
E0708_RS08180	COG3104	oligopeptide transport
E0708_RS08190	COG0339	signal peptide processing
E0708_RS08195	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E0708_RS08200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0708_RS08210	COG1393	Belongs to the ArsC family
E0708_RS08220	COG3065	identical protein binding
E0708_RS08225	COG2197	response regulator
E0708_RS08230	COG3720	iron ion transport
E0708_RS08235	COG4771	TonB-dependent receptor
E0708_RS08250	COG3721	Heme iron utilization protein
E0708_RS08260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0708_RS08270	COG1285	pathogenesis
E0708_RS08285	COG3247	response to pH
E0708_RS08290	COG2771	luxR family
E0708_RS08300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0708_RS08305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0708_RS08310	COG2207	Transcriptional regulator
E0708_RS08315	COG2207	Transcriptional regulator
E0708_RS08320	COG0076	glutamate decarboxylase activity
E0708_RS08325	COG1858	cytochrome C peroxidase
E0708_RS08335	COG2197	response regulator
E0708_RS08340	COG0583	DNA-binding transcription factor activity
E0708_RS08345	COG1295	ribonuclease BN
E0708_RS08350	COG0477	Major facilitator Superfamily
E0708_RS08355	COG2982	Protein involved in outer membrane biogenesis
E0708_RS08360	COG2200	EAL domain
E0708_RS08365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS08370	COG0612	Peptidase, M16
E0708_RS08385	COG0457	Tetratricopeptide repeat
E0708_RS08385	COG3118	belongs to the thioredoxin family
E0708_RS08390	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E0708_RS08395	COG1215	transferase activity, transferring glycosyl groups
E0708_RS08400	COG1215	transferase activity, transferring glycosyl groups
E0708_RS08425	COG2194	sulfuric ester hydrolase activity
E0708_RS08440	COG0814	amino acid
E0708_RS08445	COG4608	Belongs to the ABC transporter superfamily
E0708_RS08450	COG0444	Belongs to the ABC transporter superfamily
E0708_RS08455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0708_RS08460	COG0601	transmembrane transport
E0708_RS08470	COG0747	negative chemotaxis
E0708_RS08480	COG2194	sulfuric ester hydrolase activity
E0708_RS08485	COG2223	nitrite transmembrane transporter activity
E0708_RS08490	COG5571	outer membrane autotransporter
E0708_RS08495	COG2818	Glycosylase
E0708_RS08500	COG0456	acetyltransferase
E0708_RS08505	COG0243	molybdopterin cofactor binding
E0708_RS08510	COG2885	chlorophyll binding
E0708_RS08515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E0708_RS08525	COG2944	sequence-specific DNA binding
E0708_RS08530	COG1278	Cold shock
E0708_RS08555	COG3274	enterobacterial common antigen metabolic process
E0708_RS08560	COG4682	membrane
E0708_RS08565	COG4682	membrane
E0708_RS08570	COG1070	Carbohydrate kinase
E0708_RS08580	COG4213	ABC transporter substrate-binding protein
E0708_RS08590	COG4214	carbohydrate transport
E0708_RS08595	COG1609	Transcriptional regulator
E0708_RS08595	COG2207	Transcriptional regulator
E0708_RS08600	COG2992	FlgJ-related protein
E0708_RS08605	COG0366	Alpha amylase catalytic
E0708_RS08610	COG3977	Valine--pyruvate aminotransferase
E0708_RS08615	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0708_RS08620	COG1414	Transcriptional regulator
E0708_RS08630	COG2731	YhcH YjgK YiaL family protein
E0708_RS08640	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E0708_RS08645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0708_RS08650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0708_RS08655	COG1070	Carbohydrate kinase
E0708_RS08660	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
E0708_RS08665	COG3623	hexulose-6-phosphate isomerase
E0708_RS08670	COG0235	Class ii aldolase
E0708_RS08675	COG1012	belongs to the aldehyde dehydrogenase family
E0708_RS08685	COG1454	alcohol dehydrogenase
E0708_RS08690	COG3276	selenocysteine insertion sequence binding
E0708_RS08700	COG0625	glutathione transferase activity
E0708_RS08705	COG1566	PFAM secretion protein HlyD family protein
E0708_RS08715	COG2213	PTS system mannitol-specific
E0708_RS08715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS08725	COG3722	fumarate hydratase activity
E0708_RS08745	COG5295	Hep Hag repeat protein
E0708_RS08750	COG1620	l-lactate permease
E0708_RS08755	COG2186	Transcriptional regulator
E0708_RS08765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E0708_RS08770	COG1045	serine acetyltransferase
E0708_RS08785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E0708_RS08790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E0708_RS08800	COG4942	peptidase
E0708_RS08805	COG2861	carbohydrate metabolic process
E0708_RS08810	COG1216	Glycosyl transferase, family 2
E0708_RS08820	COG0156	8-amino-7-oxononanoate synthase activity
E0708_RS08830	COG0859	PFAM glycosyl transferase family 9
E0708_RS08835	COG0859	PFAM glycosyl transferase family 9
E0708_RS08840	COG3307	-O-antigen
E0708_RS08845	COG1216	Glycosyl transferase, family 2
E0708_RS08850	COG1442	glycosyl transferase family 8
E0708_RS08855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E0708_RS08870	COG0515	serine threonine protein kinase
E0708_RS08875	COG0438	transferase activity, transferring glycosyl groups
E0708_RS08880	COG0859	PFAM glycosyl transferase family 9
E0708_RS08885	COG1519	Transferase
E0708_RS08895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E0708_RS08915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E0708_RS08940	COG1561	YicC-like family, N-terminal region
E0708_RS08945	COG3645	SOS response
E0708_RS08950	COG2860	membrane
E0708_RS08955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E0708_RS08960	COG0194	GDP metabolic process
E0708_RS08970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E0708_RS08975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0708_RS08980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E0708_RS08985	COG0786	glutamate:sodium symporter activity
E0708_RS08990	COG2233	PERMEase
E0708_RS08995	COG2982	Protein involved in outer membrane biogenesis
E0708_RS09005	COG1940	carbohydrate kinase activity
E0708_RS09010	COG0191	fructose-bisphosphate aldolase activity
E0708_RS09020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS09020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS09025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS09030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS09030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS09030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS09035	COG3711	transcriptional antiterminator
E0708_RS09040	COG1501	Belongs to the glycosyl hydrolase 31 family
E0708_RS09045	COG2211	Major facilitator Superfamily
E0708_RS09055	COG0582	viral genome integration into host DNA
E0708_RS09085	COG2378	regulation of single-species biofilm formation
E0708_RS09090	COG3596	GTP binding
E0708_RS09120	COG2003	Belongs to the UPF0758 family
E0708_RS09160	COG0697	spore germination
E0708_RS09165	COG1464	Belongs to the NlpA lipoprotein family
E0708_RS09175	COG2814	Major facilitator Superfamily
E0708_RS09185	COG2252	PERMEase
E0708_RS09190	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E0708_RS09195	COG2271	Major facilitator Superfamily
E0708_RS09200	COG2271	Major facilitator Superfamily
E0708_RS09205	COG3851	Histidine kinase
E0708_RS09210	COG2197	response regulator
E0708_RS09220	COG0440	acetolactate synthase activity
E0708_RS09225	COG0028	Belongs to the TPP enzyme family
E0708_RS09235	COG2814	Major facilitator Superfamily
E0708_RS09240	COG0641	radical SAM
E0708_RS09250	COG2149	membrane
E0708_RS09255	COG3119	arylsulfatase activity
E0708_RS09260	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E0708_RS09265	COG2207	Transcriptional regulator
E0708_RS09285	COG5645	(Lipo)protein
E0708_RS09290	COG0823	Involved in the tonB-independent uptake of proteins
E0708_RS09295	COG0644	oxidoreductase
E0708_RS09300	COG2271	Major facilitator Superfamily
E0708_RS09310	COG0800	Aldolase
E0708_RS09315	COG3734	2-keto-3-deoxy-galactonokinase
E0708_RS09320	COG2186	Transcriptional regulator
E0708_RS09330	COG0561	phosphatase activity
E0708_RS09335	COG3753	Protein conserved in bacteria
E0708_RS09340	COG0187	DNA topoisomerase II activity
E0708_RS09350	COG0592	DNA-directed DNA polymerase activity
E0708_RS09395	COG3033	Beta-eliminating lyase
E0708_RS09400	COG0814	amino acid
E0708_RS09410	COG0583	DNA-binding transcription factor activity
E0708_RS09415	COG2091	lysine biosynthetic process via aminoadipic acid
E0708_RS09420	COG0431	NADPH-dependent FMN reductase
E0708_RS09425	COG2252	PERMEase
E0708_RS09430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0708_RS09440	COG0363	glucosamine-6-phosphate deaminase activity
E0708_RS09445	COG2382	esterase
E0708_RS09450	COG4580	involved in the transport of maltose and maltodextrins
E0708_RS09455	COG2723	6-phospho-beta-galactosidase activity
E0708_RS09460	COG2190	(PTS) system
E0708_RS09460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS09460	COG1263	PTS System
E0708_RS09465	COG3711	transcriptional antiterminator
E0708_RS09470	COG0704	Plays a role in the regulation of phosphate uptake
E0708_RS09475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E0708_RS09480	COG0581	inorganic phosphate transmembrane transporter activity
E0708_RS09485	COG0573	inorganic phosphate transmembrane transporter activity
E0708_RS09490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E0708_RS09495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E0708_RS09500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E0708_RS09545	COG3312	ion transport
E0708_RS09560	COG0716	FMN binding
E0708_RS09565	COG1522	sequence-specific DNA binding
E0708_RS09580	COG0714	Associated with various cellular activities
E0708_RS09590	COG1869	D-ribose catabolic process
E0708_RS09595	COG1129	ABC transporter
E0708_RS09600	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0708_RS09605	COG1879	ABC-type sugar transport system periplasmic component
E0708_RS09610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS09615	COG1609	Transcriptional regulator
E0708_RS09620	COG0477	Major facilitator Superfamily
E0708_RS09625	COG2186	Transcriptional regulator
E0708_RS09665	COG3085	chromosome segregation
E0708_RS09670	COG0606	chelatase, subunit chli
E0708_RS09690	COG3978	acetolactate synthase activity
E0708_RS09695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E0708_RS09700	COG0129	dihydroxy-acid dehydratase activity
E0708_RS09705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0708_RS09710	COG0583	DNA-binding transcription factor activity
E0708_RS09720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0708_RS09725	COG0210	DNA helicase
E0708_RS09740	COG3118	belongs to the thioredoxin family
E0708_RS09750	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E0708_RS09755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E0708_RS09760	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E0708_RS09765	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E0708_RS09770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E0708_RS09775	COG1088	dTDP-glucose 4,6-dehydratase activity
E0708_RS09780	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E0708_RS09785	COG0456	acetyltransferase
E0708_RS09790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E0708_RS09795	COG2244	polysaccharide biosynthetic process
E0708_RS09800	COG1819	glycosyl
E0708_RS09815	COG1113	amino acid transport
E0708_RS09840	COG0641	radical SAM
E0708_RS09845	COG3119	arylsulfatase activity
E0708_RS09850	COG3071	HemY protein
E0708_RS09855	COG2959	enzyme of heme biosynthesis
E0708_RS09860	COG1587	Uroporphyrinogen-III synthase
E0708_RS09865	COG0181	hydroxymethylbilane synthase activity
E0708_RS09870	COG3072	Adenylate cyclase
E0708_RS09875	COG1965	Belongs to the frataxin family
E0708_RS09890	COG5567	small periplasmic lipoprotein
E0708_RS09895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E0708_RS09900	COG3159	Protein conserved in bacteria
E0708_RS09910	COG1011	Hydrolase
E0708_RS09915	COG0210	DNA helicase
E0708_RS09920	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
E0708_RS09925	COG3698	Phosphodiester glycosidase
E0708_RS09930	COG0598	Magnesium transport protein CorA
E0708_RS09945	COG2962	Rard protein
E0708_RS09950	COG2050	protein possibly involved in aromatic compounds catabolism
E0708_RS09955	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E0708_RS09960	COG0514	ATP-dependent DNA helicase (RecQ)
E0708_RS09965	COG1280	lysine exporter protein (LysE YggA)
E0708_RS09970	COG1280	lysine exporter protein (LysE YggA)
E0708_RS09975	COG2267	carboxylic ester hydrolase activity
E0708_RS09980	COG0561	phosphatase activity
E0708_RS09985	COG0697	spore germination
E0708_RS09990	COG0583	DNA-binding transcription factor activity
E0708_RS09995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E0708_RS10005	COG3157	Type VI secretion system effector, Hcp
E0708_RS10010	COG3157	Type VI secretion system effector, Hcp
E0708_RS10020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS10020	COG1263	PTS System
E0708_RS10020	COG2190	(PTS) system
E0708_RS10025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E0708_RS10030	COG1737	Transcriptional regulator
E0708_RS10035	COG0583	DNA-binding transcription factor activity
E0708_RS10040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E0708_RS10050	COG0549	Belongs to the carbamate kinase family
E0708_RS10055	COG1304	FMN binding
E0708_RS10060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E0708_RS10070	COG1335	isochorismatase
E0708_RS10075	COG0412	Dienelactone hydrolase
E0708_RS10080	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E0708_RS10100	COG0800	Aldolase
E0708_RS10105	COG3734	2-keto-3-deoxy-galactonokinase
E0708_RS10110	COG1414	Transcriptional regulator
E0708_RS10115	COG1322	Protein conserved in bacteria
E0708_RS10125	COG3165	ubiquinone biosynthetic process from chorismate
E0708_RS10135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E0708_RS10145	COG0805	protein transport
E0708_RS10160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E0708_RS10165	COG0543	2 iron, 2 sulfur cluster binding
E0708_RS10170	COG0183	Belongs to the thiolase family
E0708_RS10175	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0708_RS10175	COG1024	Enoyl-CoA hydratase
E0708_RS10185	COG1739	Uncharacterized protein family UPF0029
E0708_RS10190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E0708_RS10195	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
E0708_RS10220	COG1763	Mo-molybdopterin cofactor biosynthetic process
E0708_RS10225	COG0746	molybdenum cofactor guanylyltransferase activity
E0708_RS10230	COG3084	Protein conserved in bacteria
E0708_RS10235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E0708_RS10240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E0708_RS10245	COG5339	Protein conserved in bacteria
E0708_RS10250	COG0204	Acyl-transferase
E0708_RS10255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0708_RS10255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0708_RS10270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0708_RS10280	COG2204	response regulator
E0708_RS10285	COG3852	Histidine kinase
E0708_RS10290	COG0174	glutamine synthetase
E0708_RS10300	COG2188	Transcriptional regulator
E0708_RS10305	COG1082	Xylose isomerase domain protein TIM barrel
E0708_RS10310	COG2271	Major facilitator Superfamily
E0708_RS10315	COG1349	DNA-binding transcription factor activity
E0708_RS10320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS10325	COG2084	Dehydrogenase
E0708_RS10330	COG3684	Belongs to the aldolase LacD family
E0708_RS10335	COG1063	alcohol dehydrogenase
E0708_RS10345	COG0477	Major facilitator Superfamily
E0708_RS10355	COG1011	Hydrolase
E0708_RS10370	COG0456	acetyltransferase
E0708_RS10380	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E0708_RS10405	COG2864	formate dehydrogenase
E0708_RS10410	COG0437	4 iron, 4 sulfur cluster binding
E0708_RS10420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E0708_RS10440	COG0235	Class ii aldolase
E0708_RS10445	COG4806	L-rhamnose isomerase
E0708_RS10455	COG4977	sequence-specific DNA binding
E0708_RS10470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E0708_RS10480	COG2258	MOSC domain
E0708_RS10485	COG2205	protein histidine kinase activity
E0708_RS10490	COG0745	RESPONSE REGULATOR receiver
E0708_RS10495	COG3678	ATP-independent chaperone mediated protein folding
E0708_RS10510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E0708_RS10530	COG3152	Membrane
E0708_RS10535	COG3691	Protein conserved in bacteria
E0708_RS10540	COG0589	response to stress
E0708_RS10550	COG1494	fructose-1,6-bisphosphatase
E0708_RS10555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E0708_RS10560	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E0708_RS10575	COG1575	Belongs to the MenA family. Type 1 subfamily
E0708_RS10590	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E0708_RS10595	COG1609	Transcriptional regulator
E0708_RS10600	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E0708_RS10610	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
E0708_RS10620	COG0626	cystathionine gamma-synthase activity
E0708_RS10625	COG0460	homoserine dehydrogenase
E0708_RS10625	COG0527	aspartate kinase activity
E0708_RS10635	COG0737	Belongs to the 5'-nucleotidase family
E0708_RS10640	COG0737	Belongs to the 5'-nucleotidase family
E0708_RS10650	COG0737	Belongs to the 5'-nucleotidase family
E0708_RS10655	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E0708_RS10665	COG0697	spore germination
E0708_RS10670	COG3738	Protein conserved in bacteria
E0708_RS10675	COG0371	Dehydrogenase
E0708_RS10680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E0708_RS10685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0708_RS10685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS10685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS10690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS10695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS10700	COG1882	Formate acetyltransferase
E0708_RS10705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E0708_RS10710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E0708_RS10715	COG2207	Transcriptional regulator
E0708_RS10720	COG2194	sulfuric ester hydrolase activity
E0708_RS10735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E0708_RS10740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E0708_RS10750	COG4948	Mandelate Racemase Muconate Lactonizing
E0708_RS10755	COG2271	Major facilitator Superfamily
E0708_RS10760	COG0583	DNA-binding transcription factor activity
E0708_RS10770	COG1473	amidohydrolase
E0708_RS10775	COG0477	Major facilitator Superfamily
E0708_RS10830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E0708_RS10835	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E0708_RS10835	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E0708_RS10870	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E0708_RS10875	COG0250	Participates in transcription elongation, termination and antitermination
E0708_RS10910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E0708_RS10915	COG2022	thiamine diphosphate biosynthetic process
E0708_RS10920	COG2104	thiamine diphosphate biosynthetic process
E0708_RS10925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E0708_RS10930	COG0352	thiamine-phosphate diphosphorylase activity
E0708_RS10935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E0708_RS10940	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
E0708_RS10960	COG3068	Protein conserved in bacteria
E0708_RS10975	COG3678	ATP-independent chaperone mediated protein folding
E0708_RS10980	COG4191	Histidine kinase
E0708_RS10985	COG2204	response regulator
E0708_RS10990	COG0151	Belongs to the GarS family
E0708_RS10995	COG0138	bifunctional purine biosynthesis protein purh
E0708_RS11025	COG0456	acetyltransferase
E0708_RS11035	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E0708_RS11040	COG2224	Isocitrate lyase
E0708_RS11050	COG1414	Transcriptional regulator
E0708_RS11055	COG1410	methionine synthase
E0708_RS11055	COG0646	methionine synthase
E0708_RS11070	COG1283	sodium-dependent phosphate transmembrane transporter activity
E0708_RS11115	COG1187	pseudouridine synthase activity
E0708_RS11125	COG0527	aspartate kinase activity
E0708_RS11150	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0708_RS11165	COG3833	ABC-type maltose transport systems, permease component
E0708_RS11170	COG1175	transmembrane transport
E0708_RS11175	COG2182	Extracellular solute-binding protein
E0708_RS11180	COG3842	ATPase activity
E0708_RS11210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E0708_RS11220	COG0534	Mate efflux family protein
E0708_RS11225	COG3237	CsbD-like
E0708_RS11230	COG0735	belongs to the Fur family
E0708_RS11235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E0708_RS11245	COG0604	alcohol dehydrogenase
E0708_RS11250	COG1053	succinate dehydrogenase
E0708_RS11255	COG0477	Major facilitator Superfamily
E0708_RS11260	COG1024	Enoyl-CoA hydratase
E0708_RS11270	COG1609	Transcriptional regulator
E0708_RS11275	COG0305	Participates in initiation and elongation during chromosome replication
E0708_RS11290	COG3201	nicotinamide mononucleotide transporter
E0708_RS11300	COG1448	Aminotransferase
E0708_RS11305	COG0567	Dehydrogenase, E1 component
E0708_RS11315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0708_RS11320	COG0045	succinate-CoA ligase (ADP-forming) activity
E0708_RS11325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E0708_RS11330	COG0471	metal ion transport
E0708_RS11335	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E0708_RS11340	COG2204	response regulator
E0708_RS11350	COG3700	Belongs to the class B bacterial acid phosphatase family
E0708_RS11355	COG0432	Pfam Uncharacterised protein family UPF0047
E0708_RS11360	COG2315	Protein conserved in bacteria
E0708_RS11365	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E0708_RS11370	COG0629	single-stranded DNA binding
E0708_RS11380	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E0708_RS11385	COG2207	Transcriptional regulator
E0708_RS11390	COG0789	Transcriptional regulator
E0708_RS11395	COG2252	PERMEase
E0708_RS11400	COG0025	NhaP-type Na H and K H
E0708_RS11405	COG0583	DNA-binding transcription factor activity
E0708_RS11410	COG1380	Effector of murein hydrolase LrgA
E0708_RS11415	COG1346	cytolysis
E0708_RS11425	COG3162	membrane
E0708_RS11430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0708_RS11440	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E0708_RS11445	COG0437	4 iron, 4 sulfur cluster binding
E0708_RS11450	COG3301	Polysulphide reductase, NrfD
E0708_RS11455	COG1138	Cytochrome C-type biogenesis protein
E0708_RS11460	COG3088	subunit of a heme lyase
E0708_RS11465	COG4235	cytochrome complex assembly
E0708_RS11470	COG1301	dicarboxylic acid transport
E0708_RS11475	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E0708_RS11480	COG4608	Belongs to the ABC transporter superfamily
E0708_RS11485	COG0444	Belongs to the ABC transporter superfamily
E0708_RS11495	COG0601	transmembrane transport
E0708_RS11510	COG1538	Outer membrane efflux protein
E0708_RS11515	COG1289	transmembrane transporter activity
E0708_RS11520	COG1566	PFAM secretion protein HlyD family protein
E0708_RS11530	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E0708_RS11535	COG1940	carbohydrate kinase activity
E0708_RS11540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E0708_RS11545	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0708_RS11550	COG1129	ABC transporter
E0708_RS11555	COG1879	ABC-type sugar transport system periplasmic component
E0708_RS11560	COG1737	Transcriptional regulator
E0708_RS11565	COG0698	ribose 5-phosphate isomerase
E0708_RS11575	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E0708_RS11580	COG0456	acetyltransferase
E0708_RS11590	COG3454	Phosphonate metabolism
E0708_RS11595	COG4778	phosphonate C-P lyase system protein PhnL
E0708_RS11600	COG4107	phosphonate C-P lyase system protein PhnK
E0708_RS11605	COG3627	carbon phosphorus lyase activity
E0708_RS11610	COG3626	phosphonate metabolism
E0708_RS11615	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
E0708_RS11620	COG3624	Phosphonate C-P lyase system protein PhnG
E0708_RS11625	COG2188	Transcriptional regulator
E0708_RS11630	COG3639	organic phosphonate transmembrane transporter activity
E0708_RS11635	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E0708_RS11640	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E0708_RS11645	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E0708_RS11650	COG2824	Alkylphosphonate utilization operon protein PhnA
E0708_RS11665	COG0477	Major facilitator Superfamily
E0708_RS11675	COG0642	Histidine kinase
E0708_RS11680	COG0745	RESPONSE REGULATOR receiver
E0708_RS11685	COG2194	sulfuric ester hydrolase activity
E0708_RS11690	COG0531	amino acid
E0708_RS11695	COG2207	Transcriptional regulator
E0708_RS11700	COG1982	Orn Lys Arg decarboxylase major
E0708_RS11705	COG2169	Transcriptional regulator
E0708_RS11710	COG1486	melibiose metabolic process
E0708_RS11720	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E0708_RS11720	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E0708_RS11725	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E0708_RS11730	COG4565	transcriptional regulatory protein
E0708_RS11735	COG3290	protein histidine kinase activity
E0708_RS11740	COG3592	Divergent 4Fe-4S mono-cluster
E0708_RS11745	COG2388	GCN5-related N-acetyl-transferase
E0708_RS11760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E0708_RS11765	COG3104	oligopeptide transport
E0708_RS11770	COG1982	Orn Lys Arg decarboxylase major
E0708_RS11780	COG3710	Transcriptional regulator
E0708_RS11790	COG1309	transcriptional regulator
E0708_RS11795	COG4232	protein-disulfide reductase activity
E0708_RS11810	COG1027	Aspartate ammonia-lyase
E0708_RS11815	COG3030	protein affecting phage T7 exclusion by the F plasmid
E0708_RS11820	COG0531	amino acid
E0708_RS11845	COG1509	lysine 2,3-aminomutase activity
E0708_RS11855	COG5510	response to toxic substance
E0708_RS11860	COG5510	response to toxic substance
E0708_RS11865	COG2076	Multidrug Resistance protein
E0708_RS11870	COG3040	lipid binding
E0708_RS11875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E0708_RS11890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E0708_RS11895	COG1053	succinate dehydrogenase
E0708_RS11905	COG0531	amino acid
E0708_RS11910	COG1511	domain protein
E0708_RS11910	COG3264	Mechanosensitive ion channel
E0708_RS11955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E0708_RS11955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E0708_RS11960	COG0802	atpase or kinase
E0708_RS11965	COG0860	N-Acetylmuramoyl-L-alanine amidase
E0708_RS11970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E0708_RS11985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E0708_RS11990	COG0330	HflC and HflK could
E0708_RS11995	COG0330	HflC and HflK could
E0708_RS12000	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
E0708_RS12015	COG0557	exoribonuclease II activity
E0708_RS12020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0708_RS12025	COG3789	protein conserved in bacteria
E0708_RS12030	COG1842	Phage shock protein A
E0708_RS12040	COG3766	membrane
E0708_RS12045	COG5463	Belongs to the UPF0441 family
E0708_RS12050	COG0754	glutathionylspermidine amidase activity
E0708_RS12055	COG1960	acyl-CoA dehydrogenase activity
E0708_RS12065	COG3650	response to hydrogen peroxide
E0708_RS12070	COG1073	alpha beta
E0708_RS12085	COG3037	sugar-specific permease SgaT UlaA
E0708_RS12095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS12110	COG0235	Class ii aldolase
E0708_RS12130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E0708_RS12155	COG2271	Major facilitator Superfamily
E0708_RS12160	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E0708_RS12165	COG4670	ketone body catabolic process
E0708_RS12170	COG1024	Enoyl-CoA hydratase
E0708_RS12185	COG1309	transcriptional regulator
E0708_RS12190	COG3061	Opacity-associated protein A
E0708_RS12195	COG0545	Peptidyl-prolyl cis-trans isomerase
E0708_RS12200	COG1113	amino acid transport
E0708_RS12210	COG0697	spore germination
E0708_RS12215	COG0702	epimerase
E0708_RS12220	COG1733	regulation of RNA biosynthetic process
E0708_RS12225	COG0737	Belongs to the 5'-nucleotidase family
E0708_RS12230	COG1218	3'(2'),5'-bisphosphate nucleotidase
E0708_RS12235	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
E0708_RS12245	COG1253	flavin adenine dinucleotide binding
E0708_RS12250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0708_RS12255	COG0729	surface antigen
E0708_RS12260	COG2911	Protein conserved in bacteria
E0708_RS12265	COG2105	PFAM AIG2 family protein
E0708_RS12270	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E0708_RS12275	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E0708_RS12280	COG1879	ABC-type sugar transport system periplasmic component
E0708_RS12285	COG1129	ABC transporter
E0708_RS12290	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0708_RS12295	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0708_RS12305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E0708_RS12310	COG3028	Belongs to the UPF0307 family
E0708_RS12315	COG0312	modulator of DNA gyrase
E0708_RS12320	COG3783	Cytochrome b(562)
E0708_RS12325	COG0602	queuosine metabolic process
E0708_RS12330	COG1328	CTP reductase activity
E0708_RS12335	COG0366	Alpha amylase catalytic
E0708_RS12340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS12340	COG1263	PTS System
E0708_RS12345	COG1609	Transcriptional regulator
E0708_RS12355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E0708_RS12360	COG0251	oxidation-reduction process
E0708_RS12380	COG1438	arginine binding
E0708_RS12385	COG1288	antiporter activity
E0708_RS12390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E0708_RS12395	COG0549	Belongs to the carbamate kinase family
E0708_RS12405	COG2731	YhcH YjgK YiaL family protein
E0708_RS12410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E0708_RS12415	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E0708_RS12420	COG0456	acetyltransferase
E0708_RS12430	COG0525	valine-tRNA ligase activity
E0708_RS12435	COG2927	DNA polymerase III (CHI subunit)
E0708_RS12445	COG0795	lipopolysaccharide-transporting ATPase activity
E0708_RS12450	COG0795	lipopolysaccharide-transporting ATPase activity
E0708_RS12455	COG0433	COG0433 Predicted ATPase
E0708_RS12460	COG1064	alcohol dehydrogenase
E0708_RS12515	COG2963	transposase activity
E0708_RS12520	COG2826	transposase and inactivated derivatives, IS30 family
E0708_RS12530	COG2085	NADP oxidoreductase coenzyme F420-dependent
E0708_RS12535	COG1120	ATPase activity
E0708_RS12540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0708_RS12545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0708_RS12550	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
E0708_RS12555	COG4772	TonB-dependent receptor
E0708_RS12560	COG3712	iron ion homeostasis
E0708_RS12565	COG1595	DNA-templated transcription, initiation
E0708_RS12585	COG4372	Transposase
E0708_RS12590	COG3436	PFAM IS66 Orf2 family protein
E0708_RS12640	COG3468	outer membrane autotransporter barrel domain protein
E0708_RS12665	COG2003	Belongs to the UPF0758 family
E0708_RS12740	COG1215	transferase activity, transferring glycosyl groups
E0708_RS12745	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
E0708_RS12755	COG0235	Class ii aldolase
E0708_RS12765	COG2390	Transcriptional regulator
E0708_RS12770	COG2610	gluconate transmembrane transporter activity
E0708_RS12775	COG0129	dihydroxy-acid dehydratase activity
E0708_RS12780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0708_RS12785	COG1414	Transcriptional regulator
E0708_RS12790	COG1349	DNA-binding transcription factor activity
E0708_RS12795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E0708_RS12800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS12805	COG0434	BtpA family
E0708_RS12810	COG3775	system Galactitol-specific IIC component
E0708_RS12815	COG3414	Phosphotransferase system galactitol-specific IIB component
E0708_RS12820	COG1363	Peptidase, m42
E0708_RS12830	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
E0708_RS12835	COG3153	acetyltransferase
E0708_RS12855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E0708_RS12855	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
E0708_RS12865	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
E0708_RS12870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E0708_RS12895	COG4974	Belongs to the 'phage' integrase family
E0708_RS12905	COG3539	Fimbrial protein
E0708_RS12910	COG3121	Chaperone
E0708_RS12915	COG3188	usher protein
E0708_RS12920	COG3539	Fimbrial protein
E0708_RS12925	COG3539	Fimbrial protein
E0708_RS12930	COG3539	Fimbrial protein
E0708_RS12935	COG2610	gluconate transmembrane transporter activity
E0708_RS12945	COG0246	Mannitol dehydrogenase
E0708_RS12950	COG2186	Transcriptional regulator
E0708_RS12970	COG0583	DNA-binding transcription factor activity
E0708_RS12975	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E0708_RS12980	COG0700	Nucleoside recognition
E0708_RS12985	COG3366	ferrous iron transmembrane transporter activity
E0708_RS12995	COG0477	Major facilitator Superfamily
E0708_RS13010	COG1924	4 iron, 4 sulfur cluster binding
E0708_RS13015	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
E0708_RS13020	COG2733	membrane
E0708_RS13025	COG2814	Major facilitator Superfamily
E0708_RS13040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0708_RS13045	COG5457	Domain of unknown function (DUF1127)
E0708_RS13055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E0708_RS13060	COG0732	type I restriction modification DNA specificity domain
E0708_RS13065	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E0708_RS13070	COG1715	Restriction endonuclease
E0708_RS13085	COG0523	cobalamin synthesis protein
E0708_RS13090	COG2879	small protein
E0708_RS13095	COG1966	Carbon starvation protein
E0708_RS13100	COG0840	transmembrane signaling receptor activity
E0708_RS13105	COG2271	Major facilitator Superfamily
E0708_RS13110	COG1802	Transcriptional regulator
E0708_RS13115	COG1063	alcohol dehydrogenase
E0708_RS13130	COG1484	DNA-dependent DNA replication
E0708_RS13145	COG2966	Psort location CytoplasmicMembrane, score
E0708_RS13150	COG2197	response regulator
E0708_RS13155	COG2197	response regulator
E0708_RS13160	COG4114	ferric iron reductase
E0708_RS13190	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
E0708_RS13195	COG0456	acetyltransferase
E0708_RS13200	COG1011	Hydrolase
E0708_RS13210	COG2823	Periplasmic or secreted lipoprotein
E0708_RS13220	COG4667	esterase of the alpha-beta hydrolase superfamily
E0708_RS13225	COG0084	hydrolase, TatD family'
E0708_RS13230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E0708_RS13235	COG1328	CTP reductase activity
E0708_RS13270	COG3726	membrane protein affecting hemolysin expression
E0708_RS13275	COG0560	Phosphoserine phosphatase
E0708_RS13280	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E0708_RS13285	COG1056	cytidyltransferase-related domain
E0708_RS13285	COG3172	ATPase kinase involved in NAD metabolism
E0708_RS13290	COG0488	(ABC) transporter
E0708_RS13295	COG0741	lytic transglycosylase activity
E0708_RS13315	COG3708	Transcriptional regulator
E0708_RS13315	COG2207	Transcriptional regulator
E0708_RS13320	COG3045	CreA protein
E0708_RS13325	COG0745	RESPONSE REGULATOR receiver
E0708_RS13330	COG2205	protein histidine kinase activity
E0708_RS13335	COG4452	Inner membrane protein CreD
E0708_RS13340	COG0745	RESPONSE REGULATOR receiver
E0708_RS13350	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E0708_RS13360	COG0527	aspartate kinase activity
E0708_RS13360	COG0460	homoserine dehydrogenase
E0708_RS13365	COG0083	homoserine kinase activity
E0708_RS13370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E0708_RS13385	COG1115	amino acid carrier protein
E0708_RS13395	COG0521	Mo-molybdopterin cofactor biosynthetic process
E0708_RS13400	COG1584	GPR1 FUN34 yaaH family protein
E0708_RS13405	COG4735	regulation of single-species biofilm formation
E0708_RS13435	COG3119	arylsulfatase activity
E0708_RS13450	COG0583	DNA-binding transcription factor activity
E0708_RS13465	COG0196	riboflavin kinase activity
E0708_RS13480	COG1047	Peptidyl-prolyl cis-trans
E0708_RS13505	COG0505	Belongs to the CarA family
E0708_RS13510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E0708_RS13560	COG0644	oxidoreductase
E0708_RS13565	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E0708_RS13570	COG2271	Major facilitator Superfamily
E0708_RS13580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0708_RS13580	COG0475	glutathione-regulated potassium exporter activity
E0708_RS13585	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E0708_RS13615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E0708_RS13620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0708_RS13630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E0708_RS13635	COG0564	pseudouridine synthase activity
E0708_RS13645	COG0417	DNA replication proofreading
E0708_RS13650	COG0235	Class ii aldolase
E0708_RS13655	COG2160	L-arabinose isomerase activity
E0708_RS13660	COG1069	ribulokinase activity
E0708_RS13665	COG4977	sequence-specific DNA binding
E0708_RS13685	COG0586	Pfam SNARE associated Golgi protein
E0708_RS13690	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E0708_RS13695	COG1178	ABC-type Fe3 transport system permease component
E0708_RS13700	COG4143	(ABC) transporter
E0708_RS13725	COG0473	3-isopropylmalate dehydrogenase activity
E0708_RS13740	COG0583	DNA-binding transcription factor activity
E0708_RS13745	COG0028	Belongs to the TPP enzyme family
E0708_RS13750	COG0440	acetolactate synthase activity
E0708_RS13760	COG1609	Transcriptional regulator
E0708_RS13770	COG0275	rRNA processing
E0708_RS13775	COG3116	cell division
E0708_RS13780	COG0768	penicillin binding
E0708_RS13785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E0708_RS13790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E0708_RS13800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E0708_RS13805	COG0772	Belongs to the SEDS family
E0708_RS13820	COG1181	Belongs to the D-alanine--D-alanine ligase family
E0708_RS13825	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E0708_RS13830	COG0849	cell division
E0708_RS13835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E0708_RS13855	COG0494	nUDIX hydrolase
E0708_RS13865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E0708_RS13875	COG0237	dephospho-CoA kinase activity
E0708_RS13885	COG1459	type II secretion system
E0708_RS13890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E0708_RS13895	COG4969	Belongs to the N-Me-Phe pilin family
E0708_RS13900	COG0157	Belongs to the NadC ModD family
E0708_RS13905	COG3023	N-Acetylmuramoyl-L-alanine amidase
E0708_RS13910	COG3725	Membrane protein required for beta-lactamase induction
E0708_RS13915	COG1113	amino acid transport
E0708_RS13920	COG3157	Type VI secretion system effector, Hcp
E0708_RS13950	COG2186	Transcriptional regulator
E0708_RS13955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E0708_RS13960	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0708_RS13965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0708_RS13970	COG3064	Membrane
E0708_RS13975	COG1049	propionate catabolic process, 2-methylcitrate cycle
E0708_RS14000	COG2132	Multicopper oxidase
E0708_RS14005	COG4993	Dehydrogenase
E0708_RS14010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E0708_RS14015	COG0288	reversible hydration of carbon dioxide
E0708_RS14020	COG1131	(ABC) transporter
E0708_RS14025	COG0842	Transport permease protein
E0708_RS14030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS14035	COG0726	polysaccharide deacetylase
E0708_RS14045	COG5464	transposase or invertase
E0708_RS14055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E0708_RS14065	COG3539	Fimbrial protein
E0708_RS14070	COG3539	Fimbrial protein
E0708_RS14075	COG3539	Fimbrial protein
E0708_RS14080	COG3539	Fimbrial protein
E0708_RS14085	COG3188	usher protein
E0708_RS14090	COG3121	Chaperone
E0708_RS14095	COG3539	Fimbrial protein
E0708_RS14100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E0708_RS14105	COG0617	tRNA 3'-terminal CCA addition
E0708_RS14110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0708_RS14115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E0708_RS14125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E0708_RS14130	COG1643	Atp-dependent helicase
E0708_RS14135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E0708_RS14140	COG4774	siderophore transport
E0708_RS14145	COG1120	ATPase activity
E0708_RS14150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E0708_RS14155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0708_RS14180	COG2860	membrane
E0708_RS14185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E0708_RS14200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0708_RS14205	COG3835	regulator
E0708_RS14215	COG2171	N-acyltransferase activity
E0708_RS14220	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E0708_RS14225	COG0024	Methionine aminopeptidase
E0708_RS14250	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E0708_RS14255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E0708_RS14260	COG0575	Belongs to the CDS family
E0708_RS14265	COG0750	zinc metalloprotease
E0708_RS14275	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E0708_RS14280	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0708_RS14300	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E0708_RS14305	COG0587	DNA-directed DNA polymerase activity
E0708_RS14320	COG0346	lactoylglutathione lyase activity
E0708_RS14325	COG0037	tRNA processing
E0708_RS14330	COG4568	rho-dependent transcription termination
E0708_RS14340	COG4681	YaeQ
E0708_RS14345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E0708_RS14350	COG3015	lipoprotein NlpE involved in copper resistance
E0708_RS14360	COG0791	NLP P60 protein
E0708_RS14370	COG1720	tRNA m6t6A37 methyltransferase activity
E0708_RS14380	COG1464	Belongs to the NlpA lipoprotein family
E0708_RS14385	COG2011	ABC-type metal ion transport system permease component
E0708_RS14390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E0708_RS14395	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E0708_RS14430	COG0656	L-ascorbic acid biosynthetic process
E0708_RS14435	COG0583	DNA-binding transcription factor activity
E0708_RS14445	COG2226	methyltransferase
E0708_RS14450	COG1388	LysM domain
E0708_RS14450	COG0741	lytic transglycosylase activity
E0708_RS14455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0708_RS14460	COG2226	methyltransferase
E0708_RS14470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0708_RS14495	COG3436	PFAM IS66 Orf2 family protein
E0708_RS14505	COG3547	Transposase (IS116 IS110 IS902 family)
E0708_RS14545	COG2003	Belongs to the UPF0758 family
E0708_RS14610	COG0582	viral genome integration into host DNA
E0708_RS14635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0708_RS14640	COG1120	ATPase activity
E0708_RS14710	COG0823	Involved in the tonB-independent uptake of proteins
E0708_RS14715	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS14720	COG1917	Cupin 2, conserved barrel domain protein
E0708_RS14760	COG1349	DNA-binding transcription factor activity
E0708_RS14770	COG0738	Major facilitator superfamily
E0708_RS14785	COG3037	sugar-specific permease SgaT UlaA
E0708_RS14795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS14820	COG3210	domain, Protein
E0708_RS14825	COG3210	domain, Protein
E0708_RS14845	COG3210	domain, Protein
E0708_RS14845	COG3468	outer membrane autotransporter barrel domain protein
E0708_RS14890	COG2197	response regulator
E0708_RS14910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0708_RS14920	COG1960	acyl-CoA dehydrogenase activity
E0708_RS14930	COG0121	glutamine amidotransferase
E0708_RS14935	COG3034	peptidoglycan biosynthetic process
E0708_RS14940	COG0791	NLP P60 protein
E0708_RS14955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E0708_RS14960	COG0454	-acetyltransferase
E0708_RS14965	COG1690	Belongs to the RtcB family
E0708_RS14970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E0708_RS14975	COG2195	Cleaves the N-terminal amino acid of tripeptides
E0708_RS14995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E0708_RS15005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E0708_RS15015	COG0582	viral genome integration into host DNA
E0708_RS15045	COG3477	response to acidic pH
E0708_RS15055	COG0727	PFAM Uncharacterised protein family (UPF0153)
E0708_RS15070	COG3188	usher protein
E0708_RS15110	COG1902	pentaerythritol trinitrate reductase activity
E0708_RS15115	COG1073	alpha beta
E0708_RS15120	COG0583	DNA-binding transcription factor activity
E0708_RS15130	COG0667	Aldo Keto reductase
E0708_RS15135	COG0656	L-ascorbic acid biosynthetic process
E0708_RS15140	COG1388	LysM domain
E0708_RS15145	COG2207	Transcriptional regulator
E0708_RS15145	COG3708	Transcriptional regulator
E0708_RS15150	COG0656	L-ascorbic acid biosynthetic process
E0708_RS15155	COG3059	membrane
E0708_RS15165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0708_RS15170	COG2207	Transcriptional regulator
E0708_RS15175	COG0247	lactate metabolic process
E0708_RS15180	COG1139	Iron-sulfur cluster binding protein
E0708_RS15185	COG1556	Lactate utilization protein
E0708_RS15195	COG3468	outer membrane autotransporter barrel domain protein
E0708_RS15210	COG2200	EAL domain
E0708_RS15210	COG2771	luxR family
E0708_RS15215	COG0582	viral genome integration into host DNA
E0708_RS15220	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E0708_RS15225	COG1012	belongs to the aldehyde dehydrogenase family
E0708_RS15235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E0708_RS15240	COG2200	EAL domain
E0708_RS15240	COG2771	luxR family
E0708_RS15245	COG0583	DNA-binding transcription factor activity
E0708_RS15255	COG0666	response to abiotic stimulus
E0708_RS15265	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E0708_RS15270	COG1304	FMN binding
E0708_RS15280	COG0549	Belongs to the carbamate kinase family
E0708_RS15285	COG0402	S-adenosylhomocysteine deaminase activity
E0708_RS15290	COG1064	alcohol dehydrogenase
E0708_RS15300	COG1280	lysine exporter protein (LysE YggA)
E0708_RS15310	COG3829	transcription factor binding
E0708_RS15315	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E0708_RS15320	COG0372	Belongs to the citrate synthase family
E0708_RS15325	COG2079	MmgE PrpD family protein
E0708_RS15330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0708_RS15335	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E0708_RS15340	COG0402	S-adenosylhomocysteine deaminase activity
E0708_RS15345	COG0110	maltose O-acetyltransferase activity
E0708_RS15350	COG2223	nitrite transmembrane transporter activity
E0708_RS15355	COG3250	beta-galactosidase activity
E0708_RS15360	COG1609	Transcriptional regulator
E0708_RS15370	COG3122	Protein conserved in bacteria
E0708_RS15375	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E0708_RS15400	COG1215	transferase activity, transferring glycosyl groups
E0708_RS15405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E0708_RS15410	COG4521	taurine ABC transporter
E0708_RS15415	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E0708_RS15420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0708_RS15425	COG2175	clavaminate synthase activity
E0708_RS15430	COG0113	porphobilinogen synthase activity
E0708_RS15450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0708_RS15455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E0708_RS15460	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E0708_RS15480	COG1181	Belongs to the D-alanine--D-alanine ligase family
E0708_RS15495	COG1785	Belongs to the alkaline phosphatase family
E0708_RS15505	COG3706	GGDEF domain
E0708_RS15510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E0708_RS15555	COG1940	carbohydrate kinase activity
E0708_RS15560	COG2814	Major facilitator Superfamily
E0708_RS15565	COG0419	ATPase involved in DNA repair
E0708_RS15570	COG0420	3'-5' exonuclease activity
E0708_RS15575	COG0745	RESPONSE REGULATOR receiver
E0708_RS15580	COG5002	protein histidine kinase activity
E0708_RS15585	COG1114	Component of the transport system for branched-chain amino acids
E0708_RS15590	COG1113	amino acid transport
E0708_RS15595	COG0366	Alpha amylase catalytic
E0708_RS15600	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
E0708_RS15605	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E0708_RS15620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0708_RS15625	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0708_RS15630	COG1403	HNH endonuclease
E0708_RS15635	COG3248	Nucleoside-binding outer membrane protein
E0708_RS15640	COG4238	major outer membrane lipoprotein
E0708_RS15650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0708_RS15650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0708_RS15665	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E0708_RS15670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E0708_RS15675	COG0667	Aldo Keto reductase
E0708_RS15685	COG0142	geranyltranstransferase activity
E0708_RS15700	COG0693	protein deglycase activity
E0708_RS15705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E0708_RS15715	COG2814	Major facilitator Superfamily
E0708_RS15725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E0708_RS15730	COG1845	cytochrome c oxidase, subunit III
E0708_RS15735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0708_RS15740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E0708_RS15745	COG2223	nitrite transmembrane transporter activity
E0708_RS15750	COG3056	Lipoprotein
E0708_RS15755	COG0271	Belongs to the BolA IbaG family
E0708_RS15775	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E0708_RS15780	COG0776	regulation of translation
E0708_RS15785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0708_RS15790	COG1555	photosystem II stabilization
E0708_RS15795	COG0824	Thioesterase
E0708_RS15810	COG0561	phosphatase activity
E0708_RS15815	COG1522	sequence-specific DNA binding
E0708_RS15820	COG1132	(ABC) transporter
E0708_RS15825	COG1132	(ABC) transporter
E0708_RS15830	COG0347	Belongs to the P(II) protein family
E0708_RS15835	COG0004	ammonium transporteR
E0708_RS15840	COG1946	Acyl-CoA thioesterase
E0708_RS15845	COG3126	Type III secretion system lipoprotein chaperone (YscW)
E0708_RS15850	COG3695	enzyme binding
E0708_RS15860	COG5507	3-demethylubiquinone-9 3-methyltransferase
E0708_RS15865	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E0708_RS15875	COG0110	maltose O-acetyltransferase activity
E0708_RS15890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0708_RS15895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0708_RS15900	COG1309	transcriptional regulator
E0708_RS15905	COG3264	Mechanosensitive ion channel
E0708_RS15905	COG1196	nuclear chromosome segregation
E0708_RS15915	COG3923	Primosomal replication protein n
E0708_RS15920	COG2832	Protein of unknown function (DUF454)
E0708_RS15930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E0708_RS15960	COG0657	acetylesterase activity
E0708_RS15965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS15970	COG4651	solute:proton antiporter activity
E0708_RS15970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0708_RS15975	COG2223	nitrite transmembrane transporter activity
E0708_RS15980	COG0737	Belongs to the 5'-nucleotidase family
E0708_RS15985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E0708_RS15990	COG3735	TraB family
E0708_RS16000	COG3093	addiction module antidote protein HigA
E0708_RS16005	COG2217	Heavy metal translocating P-type atpase
E0708_RS16010	COG2066	Belongs to the glutaminase family
E0708_RS16015	COG0531	amino acid
E0708_RS16020	COG0789	Transcriptional regulator
E0708_RS16030	COG1585	Membrane protein implicated in regulation of membrane protease activity
E0708_RS16035	COG0330	HflC and HflK could
E0708_RS16040	COG4619	ABC transporter
E0708_RS16045	COG0390	transport system, permease component
E0708_RS16050	COG3118	belongs to the thioredoxin family
E0708_RS16055	COG0300	oxidoreductase activity
E0708_RS16060	COG2755	lipolytic protein G-D-S-L family
E0708_RS16070	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E0708_RS16085	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E0708_RS16090	COG1414	Transcriptional regulator
E0708_RS16095	COG3960	tartronate-semialdehyde synthase activity
E0708_RS16100	COG3622	Belongs to the hyi family
E0708_RS16105	COG2084	Dehydrogenase
E0708_RS16110	COG1953	Uracil, thiamine, allantoin
E0708_RS16120	COG2233	PERMEase
E0708_RS16125	COG1929	Belongs to the glycerate kinase type-1 family
E0708_RS16130	COG3257	ureidoglycine aminohydrolase activity
E0708_RS16135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E0708_RS16140	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E0708_RS16145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E0708_RS16150	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E0708_RS16160	COG0549	Belongs to the carbamate kinase family
E0708_RS16165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E0708_RS16170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E0708_RS16180	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0708_RS16185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E0708_RS16200	COG2501	S4 domain
E0708_RS16225	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E0708_RS16230	COG0500	methyltransferase
E0708_RS16235	COG4571	Outer membrane protease
E0708_RS16245	COG4783	chaperone-mediated protein folding
E0708_RS16255	COG5002	protein histidine kinase activity
E0708_RS16260	COG0745	RESPONSE REGULATOR receiver
E0708_RS16265	COG1538	Outer membrane efflux protein
E0708_RS16270	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0708_RS16275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0708_RS16280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0708_RS16285	COG1113	amino acid transport
E0708_RS16290	COG0668	transmembrane transport
E0708_RS16295	COG0778	Nitroreductase
E0708_RS16300	COG2315	Protein conserved in bacteria
E0708_RS16310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E0708_RS16320	COG2977	Belongs to the P-Pant transferase superfamily
E0708_RS16325	COG4771	TonB-dependent receptor
E0708_RS16330	COG2382	esterase
E0708_RS16335	COG3251	PFAM MbtH domain protein
E0708_RS16340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E0708_RS16340	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E0708_RS16345	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
E0708_RS16350	COG1120	ATPase activity
E0708_RS16355	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0708_RS16360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0708_RS16370	COG4592	Periplasmic binding protein
E0708_RS16375	COG1169	isochorismate synthase
E0708_RS16380	COG1021	2,3-dihydroxybenzoate-AMP ligase
E0708_RS16385	COG3433	isochorismatase activity
E0708_RS16385	COG1535	isochorismatase
E0708_RS16390	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS16395	COG2050	protein possibly involved in aromatic compounds catabolism
E0708_RS16400	COG1966	Carbon starvation protein
E0708_RS16405	COG2879	small protein
E0708_RS16410	COG0371	Dehydrogenase
E0708_RS16415	COG0436	Aminotransferase
E0708_RS16420	COG1475	DNA binding
E0708_RS16425	COG3969	phosphoadenosine phosphosulfate
E0708_RS16430	COG0583	DNA-binding transcription factor activity
E0708_RS16435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E0708_RS16440	COG0450	alkyl hydroperoxide reductase
E0708_RS16445	COG3634	alkyl hydroperoxide reductase activity
E0708_RS16450	COG0589	response to stress
E0708_RS16455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0708_RS16460	COG3719	Belongs to the RNase T2 family
E0708_RS16465	COG0471	metal ion transport
E0708_RS16480	COG3051	citrate lyase alpha subunit
E0708_RS16485	COG2301	Belongs to the HpcH HpaI aldolase family
E0708_RS16495	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E0708_RS16500	COG3290	protein histidine kinase activity
E0708_RS16505	COG4565	transcriptional regulatory protein
E0708_RS16510	COG3069	C4-dicarboxylate transmembrane transporter activity
E0708_RS16530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0708_RS16535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E0708_RS16560	COG1686	Belongs to the peptidase S11 family
E0708_RS16565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E0708_RS16570	COG0772	Belongs to the SEDS family
E0708_RS16575	COG0768	penicillin binding
E0708_RS16585	COG0799	negative regulation of ribosome biogenesis
E0708_RS16590	COG0406	alpha-ribazole phosphatase activity
E0708_RS16600	COG1466	dna polymerase III delta subunit
E0708_RS16615	COG2888	peptidyl-tyrosine sulfation
E0708_RS16625	COG1126	abc transporter atp-binding protein
E0708_RS16630	COG0765	amino acid transport
E0708_RS16635	COG0765	amino acid transport
E0708_RS16640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0708_RS16650	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E0708_RS16655	COG4535	Mg2 and Co2 transporter CorC
E0708_RS16665	COG1702	phosphate starvation-inducible protein PhoH
E0708_RS16675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0708_RS16715	COG0367	asparagine synthase
E0708_RS16720	COG0647	UMP catabolic process
E0708_RS16725	COG1846	Transcriptional regulator
E0708_RS16725	COG1940	carbohydrate kinase activity
E0708_RS16730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E0708_RS16735	COG0363	glucosamine-6-phosphate deaminase activity
E0708_RS16740	COG1263	PTS System
E0708_RS16740	COG2190	(PTS) system
E0708_RS16740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS16760	COG0861	Integral membrane protein TerC family
E0708_RS16765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0708_RS16770	COG1454	alcohol dehydrogenase
E0708_RS16775	COG3395	kinase activity
E0708_RS16780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E0708_RS16785	COG1349	DNA-binding transcription factor activity
E0708_RS16805	COG0735	belongs to the Fur family
E0708_RS16815	COG0716	FMN binding
E0708_RS16825	COG0596	Alpha beta hydrolase
E0708_RS16830	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E0708_RS16835	COG0033	Phosphoglucomutase
E0708_RS16840	COG0531	amino acid
E0708_RS16845	COG1982	Orn Lys Arg decarboxylase major
E0708_RS16855	COG0745	RESPONSE REGULATOR receiver
E0708_RS16860	COG2205	protein histidine kinase activity
E0708_RS16875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E0708_RS16890	COG3272	Protein of unknown function (DUF1722)
E0708_RS16895	COG0415	Belongs to the DNA photolyase family
E0708_RS16905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E0708_RS16910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E0708_RS16915	COG1984	allophanate hydrolase subunit 2
E0708_RS16920	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E0708_RS16930	COG3180	Ammonia monooxygenase
E0708_RS16940	COG0372	Belongs to the citrate synthase family
E0708_RS16950	COG2009	succinate dehydrogenase
E0708_RS16955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E0708_RS16960	COG1053	succinate dehydrogenase
E0708_RS16965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E0708_RS16970	COG0567	Dehydrogenase, E1 component
E0708_RS16975	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0708_RS16985	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E0708_RS17000	COG1271	oxidase subunit
E0708_RS17005	COG1294	oxidase, subunit
E0708_RS17010	COG4890	Cyd operon protein YbgT
E0708_RS17015	COG3790	cyd operon protein YbgE
E0708_RS17020	COG0824	Thioesterase
E0708_RS17025	COG0811	peptide transport
E0708_RS17030	COG0848	biopolymer transport protein
E0708_RS17035	COG3064	Membrane
E0708_RS17045	COG2885	chlorophyll binding
E0708_RS17050	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E0708_RS17090	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E0708_RS17095	COG3201	nicotinamide mononucleotide transporter
E0708_RS17110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E0708_RS17120	COG2017	converts alpha-aldose to the beta-anomer
E0708_RS17130	COG1085	galactose-1-phosphate uridylyltransferase
E0708_RS17135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E0708_RS17140	COG1119	ATPase activity
E0708_RS17145	COG2005	Transcriptional regulator
E0708_RS17145	COG3585	molybdate ion transport
E0708_RS17155	COG0725	ABC transporter, periplasmic molybdate-binding protein
E0708_RS17160	COG4149	molybdate abc transporter
E0708_RS17165	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E0708_RS17170	COG0561	phosphatase activity
E0708_RS17180	COG0583	DNA-binding transcription factor activity
E0708_RS17185	COG2828	Protein conserved in bacteria
E0708_RS17190	COG0471	metal ion transport
E0708_RS17195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E0708_RS17200	COG4677	pectinesterase activity
E0708_RS17205	COG1881	PFAM PEBP family protein
E0708_RS17215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E0708_RS17225	COG0156	8-amino-7-oxononanoate synthase activity
E0708_RS17230	COG2226	methyltransferase
E0708_RS17235	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E0708_RS17245	COG0391	Required for morphogenesis under gluconeogenic growth conditions
E0708_RS17255	COG0521	Mo-molybdopterin cofactor biosynthetic process
E0708_RS17265	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E0708_RS17270	COG0314	molybdopterin synthase activity
E0708_RS17275	COG0670	Belongs to the BI1 family
E0708_RS17280	COG0670	Belongs to the BI1 family
E0708_RS17285	COG0392	lysyltransferase activity
E0708_RS17290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E0708_RS17295	COG3568	Endonuclease Exonuclease Phosphatase
E0708_RS17305	COG0842	Transport permease protein
E0708_RS17310	COG0842	Transport permease protein
E0708_RS17315	COG1131	(ABC) transporter
E0708_RS17325	COG1309	transcriptional regulator
E0708_RS17330	COG0513	Belongs to the DEAD box helicase family
E0708_RS17340	COG1199	ATP-dependent helicase activity
E0708_RS17345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E0708_RS17350	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E0708_RS17360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E0708_RS17365	COG3128	pkhd-type hydroxylase
E0708_RS17370	COG4774	siderophore transport
E0708_RS17380	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
E0708_RS17385	COG0668	transmembrane transport
E0708_RS17390	COG1126	abc transporter atp-binding protein
E0708_RS17395	COG0765	amino acid transport
E0708_RS17400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0708_RS17405	COG0783	Belongs to the Dps family
E0708_RS17410	COG5006	permease, DMT superfamily
E0708_RS17420	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E0708_RS17425	COG2194	sulfuric ester hydrolase activity
E0708_RS17435	COG1321	iron dependent repressor
E0708_RS17440	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E0708_RS17445	COG1376	ErfK ybiS ycfS ynhG family protein
E0708_RS17455	COG0561	phosphatase activity
E0708_RS17460	COG1882	Formate acetyltransferase
E0708_RS17465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E0708_RS17470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E0708_RS17475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E0708_RS17480	COG0303	'Molybdopterin
E0708_RS17490	COG4172	Belongs to the ABC transporter superfamily
E0708_RS17510	COG2200	EAL domain
E0708_RS17515	COG2199	diguanylate cyclase activity
E0708_RS17535	COG0625	glutathione transferase activity
E0708_RS17540	COG1686	Belongs to the peptidase S11 family
E0708_RS17545	COG1349	DNA-binding transcription factor activity
E0708_RS17550	COG0671	phosphoesterase, PA-phosphatase related
E0708_RS17555	COG2814	Major facilitator Superfamily
E0708_RS17565	COG0561	phosphatase activity
E0708_RS17570	COG0738	Major facilitator superfamily
E0708_RS17575	COG3226	Transcriptional regulator
E0708_RS17590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E0708_RS17600	COG0778	Nitroreductase
E0708_RS17615	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E0708_RS17620	COG3842	ATPase activity
E0708_RS17625	COG1176	ABC-type spermidine putrescine transport system, permease component I
E0708_RS17630	COG1177	transmembrane transport
E0708_RS17640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E0708_RS17650	COG4160	amino acid transport
E0708_RS17655	COG4215	(ABC) transporter
E0708_RS17660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0708_RS17665	COG1126	abc transporter atp-binding protein
E0708_RS17680	COG3023	N-Acetylmuramoyl-L-alanine amidase
E0708_RS17685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0708_RS17690	COG0702	epimerase
E0708_RS17695	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E0708_RS17700	COG0028	Belongs to the TPP enzyme family
E0708_RS17705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E0708_RS17710	COG1151	hydroxylamine reductase activity
E0708_RS17715	COG2431	L-lysine efflux transmembrane transporter activity
E0708_RS17725	COG3593	DNA synthesis involved in DNA repair
E0708_RS17730	COG2990	Protein conserved in bacteria
E0708_RS17735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0708_RS17745	COG1278	Cold shock
E0708_RS17755	COG0542	response to heat
E0708_RS17775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E0708_RS17780	COG4988	ABC transporter
E0708_RS17785	COG0492	ferredoxin-NADP+ reductase activity
E0708_RS17790	COG1522	sequence-specific DNA binding
E0708_RS17795	COG1674	ftsk spoiiie
E0708_RS17795	COG1178	ABC-type Fe3 transport system permease component
E0708_RS17805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E0708_RS17815	COG0243	molybdopterin cofactor binding
E0708_RS17820	COG0437	4 iron, 4 sulfur cluster binding
E0708_RS17825	COG3302	dmso reductase anchor subunit
E0708_RS17830	COG1335	isochorismatase
E0708_RS17840	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E0708_RS17845	COG1882	Formate acetyltransferase
E0708_RS17850	COG2116	formate transmembrane transporter activity
E0708_RS17855	COG1944	ATP diphosphatase activity
E0708_RS17860	COG2323	membrane
E0708_RS17870	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E0708_RS17875	COG0501	Belongs to the peptidase M48B family
E0708_RS17885	COG0539	negative regulation of cytoplasmic translation
E0708_RS17895	COG2333	competence protein COMEC
E0708_RS17895	COG0658	competence protein
E0708_RS17910	COG3214	Protein conserved in bacteria
E0708_RS17920	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E0708_RS17925	COG3173	Aminoglycoside phosphotransferase
E0708_RS17930	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E0708_RS17935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E0708_RS17945	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
E0708_RS17950	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E0708_RS17955	COG2989	Protein conserved in bacteria
E0708_RS17960	COG3108	Peptidase M15
E0708_RS17965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0708_RS17970	COG1448	Aminotransferase
E0708_RS17990	COG0308	aminopeptidase N
E0708_RS17995	COG1116	anion transmembrane transporter activity
E0708_RS18000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0708_RS18010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E0708_RS18015	COG0431	NADPH-dependent FMN reductase
E0708_RS18030	COG0633	Ferredoxin
E0708_RS18030	COG3217	Mosc domain protein beta barrel domain protein
E0708_RS18035	COG0116	Belongs to the methyltransferase superfamily
E0708_RS18035	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E0708_RS18040	COG0488	(ABC) transporter
E0708_RS18045	COG2995	paraquat-inducible protein a
E0708_RS18050	COG3008	intermembrane lipid transfer
E0708_RS18050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E0708_RS18055	COG3009	Protein conserved in bacteria
E0708_RS18060	COG3130	regulation of translation
E0708_RS18070	COG1067	ATP-dependent peptidase activity
E0708_RS18090	COG3070	regulator of competence-specific genes
E0708_RS18095	COG1289	transmembrane transporter activity
E0708_RS18100	COG3304	Inner membrane component domain
E0708_RS18105	COG0210	DNA helicase
E0708_RS18120	COG1832	CoA-binding protein
E0708_RS18135	COG1254	Belongs to the acylphosphatase family
E0708_RS18140	COG2920	part of a sulfur-relay system
E0708_RS18145	COG0670	Belongs to the BI1 family
E0708_RS18155	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E0708_RS18160	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E0708_RS18165	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E0708_RS18170	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E0708_RS18175	COG1999	signal sequence binding
E0708_RS18180	COG1773	rubredoxin
E0708_RS18185	COG1271	oxidase subunit
E0708_RS18190	COG1294	oxidase, subunit
E0708_RS18205	COG1278	Cold shock
E0708_RS18210	COG1278	Cold shock
E0708_RS18230	COG0348	domain, Protein
E0708_RS18235	COG0784	Response regulator, receiver
E0708_RS18235	COG2198	Histidine kinase
E0708_RS18235	COG2205	protein histidine kinase activity
E0708_RS18240	COG1879	ABC-type sugar transport system periplasmic component
E0708_RS18245	COG0745	RESPONSE REGULATOR receiver
E0708_RS18250	COG3005	denitrification pathway
E0708_RS18255	COG0243	molybdopterin cofactor binding
E0708_RS18260	COG3381	protein complex oligomerization
E0708_RS18290	COG3729	General stress protein
E0708_RS18295	COG2233	PERMEase
E0708_RS18300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E0708_RS18305	COG0778	Nitroreductase
E0708_RS18310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E0708_RS18320	COG1335	isochorismatase
E0708_RS18325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E0708_RS18330	COG1309	transcriptional regulator
E0708_RS18335	COG0506	proline dehydrogenase activity
E0708_RS18335	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E0708_RS18335	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E0708_RS18345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E0708_RS18350	COG0672	)-iron permease
E0708_RS18355	COG2822	iron ion transport
E0708_RS18365	COG1702	phosphate starvation-inducible protein PhoH
E0708_RS18370	COG3658	cytochrome
E0708_RS18375	COG1215	transferase activity, transferring glycosyl groups
E0708_RS18380	COG0726	polysaccharide deacetylase
E0708_RS18380	COG1649	PFAM Uncharacterised BCR, COG1649
E0708_RS18385	COG0457	Tetratricopeptide repeat
E0708_RS18390	COG3706	GGDEF domain
E0708_RS18395	COG0582	viral genome integration into host DNA
E0708_RS18420	COG4983	Phage plasmid primase, P4 family domain protein
E0708_RS18430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E0708_RS18440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E0708_RS18450	COG2222	sugar isomerase
E0708_RS18470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0708_RS18475	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS18485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0708_RS18510	COG1216	Glycosyl transferase, family 2
E0708_RS18515	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E0708_RS18530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0708_RS18540	COG0204	Acyl-transferase
E0708_RS18570	COG3210	domain, Protein
E0708_RS18575	COG3210	domain, Protein
E0708_RS18615	COG4644	lycopene metabolic process
E0708_RS18620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E0708_RS18645	COG2994	toxin metabolic process
E0708_RS18700	COG3539	Fimbrial protein
E0708_RS18740	COG3335	DDE superfamily endonuclease
E0708_RS18745	COG4771	TonB-dependent receptor
E0708_RS18750	COG2819	hydrolase of the alpha beta superfamily
E0708_RS18755	COG2382	esterase
E0708_RS18800	COG4771	TonB-dependent receptor
E0708_RS18810	COG0523	cobalamin synthesis protein
E0708_RS18855	COG3468	outer membrane autotransporter barrel domain protein
E0708_RS18860	COG2020	methyltransferase activity
E0708_RS18885	COG2003	Belongs to the UPF0758 family
E0708_RS18930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0708_RS18940	COG3381	protein complex oligomerization
E0708_RS18950	COG1462	curli production assembly transport component CsgG
E0708_RS18965	COG2197	response regulator
E0708_RS18990	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E0708_RS18995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E0708_RS19010	COG2943	transferase activity, transferring hexosyl groups
E0708_RS19015	COG5645	(Lipo)protein
E0708_RS19030	COG1560	Kdo2-lipid A biosynthetic process
E0708_RS19040	COG2353	YceI-like domain
E0708_RS19045	COG3038	cytochrome b561
E0708_RS19055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0708_RS19070	COG0418	dihydroorotase activity
E0708_RS19080	COG2999	glutathione oxidoreductase activity
E0708_RS19090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E0708_RS19100	COG0673	inositol 2-dehydrogenase activity
E0708_RS19105	COG0728	peptidoglycan biosynthetic process
E0708_RS19110	COG3418	PFAM FlgN family protein
E0708_RS19115	COG2747	anti-sigma28 factor FlgM
E0708_RS19120	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E0708_RS19125	COG1815	bacterial-type flagellum-dependent cell motility
E0708_RS19130	COG1558	bacterial-type flagellum-dependent cell motility
E0708_RS19135	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E0708_RS19145	COG4787	bacterial-type flagellum-dependent cell motility
E0708_RS19160	COG1706	bacterial-type flagellum-dependent cell motility
E0708_RS19165	COG3951	Flagellar rod assembly protein muramidase FlgJ
E0708_RS19165	COG1705	Flagellar rod assembly protein muramidase FlgJ
E0708_RS19170	COG1256	bacterial-type flagellum assembly
E0708_RS19175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E0708_RS19180	COG1530	ribonuclease E activity
E0708_RS19185	COG0564	pseudouridine synthase activity
E0708_RS19190	COG0424	maF-like protein
E0708_RS19195	COG1399	metal-binding, possibly nucleic acid-binding protein
E0708_RS19215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E0708_RS19220	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS19230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0708_RS19235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E0708_RS19240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E0708_RS19245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E0708_RS19250	COG0470	DNA polymerase III
E0708_RS19255	COG0084	hydrolase, TatD family'
E0708_RS19260	COG1263	PTS System
E0708_RS19260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS19265	COG4773	Receptor
E0708_RS19270	COG0537	adenosine 5'-monophosphoramidase activity
E0708_RS19275	COG5633	Lipoprotein
E0708_RS19280	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
E0708_RS19285	COG0510	thiamine kinase activity
E0708_RS19290	COG1472	Belongs to the glycosyl hydrolase 3 family
E0708_RS19300	COG1252	NADH dehydrogenase
E0708_RS19305	COG3134	Outer membrane lipoprotein
E0708_RS19310	COG1309	transcriptional regulator
E0708_RS19320	COG1388	LysM domain
E0708_RS19320	COG1376	ErfK ybiS ycfS ynhG family protein
E0708_RS19325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E0708_RS19330	COG4763	Acyl-transferase
E0708_RS19335	COG4591	ABC-type transport system involved in lipoprotein release permease component
E0708_RS19345	COG4591	ABC-type transport system involved in lipoprotein release permease component
E0708_RS19350	COG1940	carbohydrate kinase activity
E0708_RS19370	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E0708_RS19375	COG1177	transmembrane transport
E0708_RS19390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0708_RS19445	COG1846	Transcriptional regulator
E0708_RS19450	COG1484	DNA-dependent DNA replication
E0708_RS19455	COG1846	Transcriptional regulator
E0708_RS19515	COG1403	HNH endonuclease
E0708_RS19520	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E0708_RS19570	COG3772	lysozyme
E0708_RS19600	COG4220	transposase activity
E0708_RS19705	COG5301	cellulose 1,4-beta-cellobiosidase activity
E0708_RS19710	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E0708_RS19715	COG0500	methyltransferase
E0708_RS19730	COG3842	ATPase activity
E0708_RS19740	COG2850	peptidyl-arginine hydroxylation
E0708_RS19745	COG2205	protein histidine kinase activity
E0708_RS19755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E0708_RS19775	COG1187	pseudouridine synthase activity
E0708_RS19780	COG0538	isocitrate dehydrogenase activity
E0708_RS19790	COG5562	phage envelope protein
E0708_RS19795	COG0789	Transcriptional regulator
E0708_RS19800	COG2200	EAL domain
E0708_RS19880	COG2894	cell division
E0708_RS19905	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0708_RS19920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E0708_RS19925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E0708_RS19935	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E0708_RS19945	COG2719	SpoVR family
E0708_RS19955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E0708_RS19965	COG1619	proteins homologs of microcin C7 resistance protein MccF
E0708_RS19975	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E0708_RS19990	COG0157	Belongs to the NadC ModD family
E0708_RS19995	COG0500	methyltransferase
E0708_RS20000	COG1120	ATPase activity
E0708_RS20020	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E0708_RS20025	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
E0708_RS20025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS20025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0708_RS20030	COG1461	Dihydroxyacetone kinase
E0708_RS20035	COG2376	Dihydroxyacetone kinase
E0708_RS20040	COG3284	Transcriptional regulator
E0708_RS20050	COG0012	GTP binding
E0708_RS20065	COG0659	secondary active sulfate transmembrane transporter activity
E0708_RS20070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E0708_RS20075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E0708_RS20080	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E0708_RS20095	COG2890	protein-(glutamine-N5) methyltransferase activity
E0708_RS20100	COG3094	Invasion gene expression up-regulator, SirB
E0708_RS20105	COG2912	Transglutaminase-like superfamily
E0708_RS20120	COG0387	Pfam Sodium calcium exchanger
E0708_RS20125	COG4572	Cation transport regulator
E0708_RS20130	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E0708_RS20135	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E0708_RS20140	COG4932	domain protein
E0708_RS20145	COG2197	response regulator
E0708_RS20150	COG3850	Histidine kinase
E0708_RS20155	COG2223	nitrite transmembrane transporter activity
E0708_RS20160	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E0708_RS20165	COG1140	nitrate reductase beta subunit
E0708_RS20170	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E0708_RS20175	COG2181	nitrate reductase activity
E0708_RS20180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E0708_RS20185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0708_RS20230	COG0788	formyltetrahydrofolate deformylase activity
E0708_RS20240	COG1752	Esterase of the alpha-beta hydrolase superfamily
E0708_RS20245	COG0745	RESPONSE REGULATOR receiver
E0708_RS20250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E0708_RS20260	COG1435	thymidine kinase activity
E0708_RS20270	COG1012	belongs to the aldehyde dehydrogenase family
E0708_RS20270	COG1454	alcohol dehydrogenase
E0708_RS20275	COG2095	MarC family integral membrane protein
E0708_RS20285	COG4166	transmembrane transport
E0708_RS20290	COG0601	transmembrane transport
E0708_RS20295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0708_RS20300	COG0444	Belongs to the ABC transporter superfamily
E0708_RS20305	COG4608	Belongs to the ABC transporter superfamily
E0708_RS20325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0708_RS20335	COG2350	Protein conserved in bacteria
E0708_RS20345	COG1607	acyl-coa hydrolase
E0708_RS20365	COG3047	cAMP biosynthetic process
E0708_RS20370	COG3685	Protein conserved in bacteria
E0708_RS20375	COG3685	Protein conserved in bacteria
E0708_RS20380	COG0159	tryptophan synthase activity
E0708_RS20390	COG0135	phosphoribosylanthranilate isomerase activity
E0708_RS20390	COG0134	indole-3-glycerol-phosphate synthase activity
E0708_RS20395	COG0512	Glutamine amidotransferase of anthranilate synthase
E0708_RS20395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E0708_RS20400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E0708_RS20410	COG0613	PHP domain protein
E0708_RS20415	COG0009	L-threonylcarbamoyladenylate synthase
E0708_RS20420	COG4907	membrane protein (DUF2207)
E0708_RS20425	COG1187	pseudouridine synthase activity
E0708_RS20430	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E0708_RS20435	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS20440	COG0616	signal peptide processing
E0708_RS20450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E0708_RS20455	COG0583	DNA-binding transcription factor activity
E0708_RS20475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E0708_RS20485	COG0671	phosphoesterase, PA-phosphatase related
E0708_RS20490	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
E0708_RS20495	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E0708_RS20505	COG0023	Translation Initiation Factor
E0708_RS20515	COG1349	DNA-binding transcription factor activity
E0708_RS20525	COG5001	Diguanylate cyclase
E0708_RS20540	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0708_RS20540	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0708_RS20545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E0708_RS20555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0708_RS20560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0708_RS20570	COG2814	Major facilitator Superfamily
E0708_RS20575	COG4172	Belongs to the ABC transporter superfamily
E0708_RS20580	COG4172	Belongs to the ABC transporter superfamily
E0708_RS20585	COG4171	peptide transport system, permease
E0708_RS20590	COG4168	peptide transport system, permease
E0708_RS20595	COG4166	transmembrane transport
E0708_RS20610	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E0708_RS20615	COG1842	Phage shock protein A
E0708_RS20625	COG1983	PspC domain protein
E0708_RS20635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E0708_RS20640	COG0366	Alpha amylase catalytic
E0708_RS20645	COG1653	transport
E0708_RS20650	COG1175	transmembrane transport
E0708_RS20655	COG0395	ABC-type sugar transport system, permease component
E0708_RS20660	COG1063	alcohol dehydrogenase
E0708_RS20665	COG1082	Xylose isomerase domain protein TIM barrel
E0708_RS20670	COG0673	inositol 2-dehydrogenase activity
E0708_RS20675	COG1554	hydrolase, family 65, central catalytic
E0708_RS20680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0708_RS20685	COG3842	ATPase activity
E0708_RS20695	COG1609	Transcriptional regulator
E0708_RS20700	COG3106	COG3106 Predicted ATPase
E0708_RS20710	COG3283	Transcriptional regulator of aromatic amino acids metabolism
E0708_RS20715	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E0708_RS20720	COG4948	Mandelate Racemase Muconate Lactonizing
E0708_RS20730	COG0702	epimerase
E0708_RS20740	COG1073	alpha beta
E0708_RS20750	COG4166	transmembrane transport
E0708_RS20755	COG0668	transmembrane transport
E0708_RS20760	COG3182	Iron-regulated membrane protein
E0708_RS20765	COG0589	response to stress
E0708_RS20770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0708_RS20785	COG2207	Transcriptional regulator
E0708_RS20790	COG1566	PFAM secretion protein HlyD family protein
E0708_RS20800	COG2840	Smr protein MutS2
E0708_RS20805	COG3706	GGDEF domain
E0708_RS20815	COG0513	Belongs to the DEAD box helicase family
E0708_RS20840	COG0589	response to stress
E0708_RS20845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E0708_RS20850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0708_RS20850	COG0674	pyruvate-flavodoxin oxidoreductase activity
E0708_RS20850	COG1013	pyruvate-flavodoxin oxidoreductase activity
E0708_RS20850	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E0708_RS20855	COG3042	response to heat
E0708_RS20860	COG3187	Heat shock protein
E0708_RS20865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E0708_RS20870	COG2911	Protein conserved in bacteria
E0708_RS20880	COG3784	Protein of unknown function (DUF1318)
E0708_RS20890	COG0667	Aldo Keto reductase
E0708_RS20895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E0708_RS20900	COG4589	Belongs to the CDS family
E0708_RS20905	COG2267	carboxylic ester hydrolase activity
E0708_RS20910	COG2453	phosphatase
E0708_RS20910	COG0671	phosphoesterase, PA-phosphatase related
E0708_RS20915	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E0708_RS20920	COG1643	Atp-dependent helicase
E0708_RS20925	COG1434	Gram-negative-bacterium-type cell wall biogenesis
E0708_RS20930	COG1012	belongs to the aldehyde dehydrogenase family
E0708_RS20935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E0708_RS20940	COG3038	cytochrome b561
E0708_RS20960	COG0583	DNA-binding transcription factor activity
E0708_RS20965	COG5383	Protein conserved in bacteria
E0708_RS20975	COG2841	Protein conserved in bacteria
E0708_RS20980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E0708_RS20985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E0708_RS20990	COG1275	C4-dicarboxylate transporter malic acid transport protein
E0708_RS20995	COG0500	methyltransferase
E0708_RS21005	COG3135	benzoate transporter
E0708_RS21010	COG1396	sequence-specific DNA binding
E0708_RS21015	COG0826	peptidase U32
E0708_RS21030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0708_RS21035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E0708_RS21040	COG3842	ATPase activity
E0708_RS21045	COG1176	ABC-type spermidine putrescine transport system, permease component I
E0708_RS21050	COG1177	transmembrane transport
E0708_RS21075	COG3238	Protein conserved in bacteria
E0708_RS21080	COG1247	-acetyltransferase
E0708_RS21095	COG4772	TonB-dependent receptor
E0708_RS21100	COG3391	amine dehydrogenase activity
E0708_RS21105	COG1113	amino acid transport
E0708_RS21110	COG0625	glutathione transferase activity
E0708_RS21115	COG0625	glutathione transferase activity
E0708_RS21125	COG3501	Rhs element vgr protein
E0708_RS21150	COG3501	Rhs element vgr protein
E0708_RS21180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E0708_RS21185	COG2162	N-hydroxyarylamine O-acetyltransferase activity
E0708_RS21190	COG0384	phenazine biosynthesis protein PhzF
E0708_RS21195	COG2181	nitrate reductase activity
E0708_RS21200	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E0708_RS21205	COG1140	nitrate reductase beta subunit
E0708_RS21210	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E0708_RS21215	COG2223	nitrite transmembrane transporter activity
E0708_RS21220	COG0697	spore germination
E0708_RS21230	COG0437	4 iron, 4 sulfur cluster binding
E0708_RS21235	COG2864	formate dehydrogenase
E0708_RS21240	COG3093	addiction module antidote protein HigA
E0708_RS21250	COG1064	alcohol dehydrogenase
E0708_RS21255	COG0281	malic enzyme
E0708_RS21270	COG1764	response to oxidative stress
E0708_RS21275	COG2202	Pas domain
E0708_RS21275	COG2200	EAL domain
E0708_RS21275	COG2199	diguanylate cyclase activity
E0708_RS21280	COG3706	GGDEF domain
E0708_RS21280	COG3706	GGDEF domain
E0708_RS21290	COG0531	amino acid
E0708_RS21295	COG0076	glutamate decarboxylase activity
E0708_RS21300	COG0612	Peptidase, M16
E0708_RS21305	COG4771	TonB-dependent receptor
E0708_RS21310	COG4178	(ABC) transporter
E0708_RS21320	COG0641	radical SAM
E0708_RS21325	COG3119	arylsulfatase activity
E0708_RS21330	COG2207	Transcriptional regulator
E0708_RS21340	COG0243	molybdopterin cofactor binding
E0708_RS21345	COG3539	Fimbrial protein
E0708_RS21350	COG3539	Fimbrial protein
E0708_RS21355	COG3539	Fimbrial protein
E0708_RS21360	COG3188	usher protein
E0708_RS21375	COG0702	epimerase
E0708_RS21385	COG3550	peptidyl-serine autophosphorylation
E0708_RS21390	COG1396	sequence-specific DNA binding
E0708_RS21395	COG4106	trans-aconitate 2-methyltransferase activity
E0708_RS21400	COG3781	membrane
E0708_RS21410	COG2199	diguanylate cyclase activity
E0708_RS21420	COG2066	Belongs to the glutaminase family
E0708_RS21430	COG0583	DNA-binding transcription factor activity
E0708_RS21450	COG1846	Transcriptional regulator
E0708_RS21455	COG4977	sequence-specific DNA binding
E0708_RS21465	COG2723	6-phospho-beta-galactosidase activity
E0708_RS21475	COG1447	Phosphotransferase system cellobiose-specific component IIA
E0708_RS21480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E0708_RS21490	COG2188	Transcriptional regulator
E0708_RS21495	COG0697	spore germination
E0708_RS21500	COG2814	Major facilitator Superfamily
E0708_RS21510	COG3706	GGDEF domain
E0708_RS21515	COG3111	PFAM Bacterial OB fold (BOF) protein
E0708_RS21520	COG0339	signal peptide processing
E0708_RS21525	COG4221	oxidoreductase activity
E0708_RS21530	COG1802	Transcriptional regulator
E0708_RS21540	COG0246	Mannitol dehydrogenase
E0708_RS21545	COG0477	Major facilitator Superfamily
E0708_RS21560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E0708_RS21565	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E0708_RS21570	COG5301	cellulose 1,4-beta-cellobiosidase activity
E0708_RS21645	COG0740	serine-type endopeptidase activity
E0708_RS21675	COG5562	phage envelope protein
E0708_RS21700	COG1278	Cold shock
E0708_RS21710	COG3772	lysozyme
E0708_RS21725	COG1278	Cold shock
E0708_RS21735	COG0484	heat shock protein binding
E0708_RS21790	COG1396	sequence-specific DNA binding
E0708_RS21815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0708_RS21825	COG0582	viral genome integration into host DNA
E0708_RS21835	COG1063	alcohol dehydrogenase
E0708_RS21840	COG4948	Mandelate Racemase Muconate Lactonizing
E0708_RS21855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E0708_RS21870	COG0243	molybdopterin cofactor binding
E0708_RS21880	COG0437	4 iron, 4 sulfur cluster binding
E0708_RS21885	COG3302	dmso reductase anchor subunit
E0708_RS21890	COG3381	protein complex oligomerization
E0708_RS21900	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E0708_RS21905	COG1940	carbohydrate kinase activity
E0708_RS21910	COG0583	DNA-binding transcription factor activity
E0708_RS21915	COG2814	Major facilitator Superfamily
E0708_RS21930	COG3591	Belongs to the peptidase S1B family
E0708_RS21935	COG2076	Multidrug Resistance protein
E0708_RS21940	COG2076	Multidrug Resistance protein
E0708_RS21945	COG0628	permease
E0708_RS21950	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E0708_RS21955	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E0708_RS21965	COG0531	amino acid
E0708_RS21970	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS21975	COG3136	membrane protein required for alginate biosynthesis
E0708_RS21980	COG0745	RESPONSE REGULATOR receiver
E0708_RS21985	COG2205	protein histidine kinase activity
E0708_RS21995	COG0114	fumarate hydratase activity
E0708_RS22000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E0708_RS22000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E0708_RS22005	COG1482	cell wall glycoprotein biosynthetic process
E0708_RS22010	COG5339	Protein conserved in bacteria
E0708_RS22025	COG3250	beta-galactosidase activity
E0708_RS22030	COG1309	transcriptional regulator
E0708_RS22035	COG1028	Short-chain dehydrogenase reductase Sdr
E0708_RS22040	COG1609	Transcriptional regulator
E0708_RS22045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS22045	COG1263	PTS System
E0708_RS22050	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E0708_RS22060	COG0673	inositol 2-dehydrogenase activity
E0708_RS22085	COG2878	Part of a membrane complex involved in electron transport
E0708_RS22100	COG4659	FMN binding
E0708_RS22105	COG4660	Part of a membrane complex involved in electron transport
E0708_RS22110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E0708_RS22115	COG3104	oligopeptide transport
E0708_RS22120	COG0625	glutathione transferase activity
E0708_RS22125	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E0708_RS22140	COG3895	Periplasmic Protein
E0708_RS22150	COG3133	Outer membrane lipoprotein
E0708_RS22165	COG1566	PFAM secretion protein HlyD family protein
E0708_RS22170	COG1289	transmembrane transporter activity
E0708_RS22175	COG2032	superoxide dismutase activity
E0708_RS22180	COG4989	oxidoreductase activity
E0708_RS22185	COG3313	Fe-S protein
E0708_RS22190	COG1309	transcriptional regulator
E0708_RS22195	COG1902	pentaerythritol trinitrate reductase activity
E0708_RS22200	COG0346	lactoylglutathione lyase activity
E0708_RS22210	COG1201	RNA secondary structure unwinding
E0708_RS22215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E0708_RS22220	COG0791	NLP P60 protein
E0708_RS22225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E0708_RS22230	COG2814	Major facilitator Superfamily
E0708_RS22240	COG1609	Transcriptional regulator
E0708_RS22245	COG0583	DNA-binding transcription factor activity
E0708_RS22250	COG2814	Major facilitator Superfamily
E0708_RS22255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E0708_RS22260	COG0307	riboflavin synthase, alpha
E0708_RS22270	COG3468	outer membrane autotransporter barrel domain protein
E0708_RS22290	COG4529	Protein conserved in bacteria
E0708_RS22300	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E0708_RS22305	COG0437	4 iron, 4 sulfur cluster binding
E0708_RS22315	COG2414	aldehyde ferredoxin oxidoreductase
E0708_RS22320	COG0437	4 iron, 4 sulfur cluster binding
E0708_RS22330	COG0469	pyruvate kinase activity
E0708_RS22335	COG4238	major outer membrane lipoprotein
E0708_RS22340	COG1376	ErfK ybiS ycfS ynhG family protein
E0708_RS22355	COG0719	Fe-S assembly protein
E0708_RS22360	COG0396	ATPase activity
E0708_RS22365	COG0719	Fe-S assembly protein
E0708_RS22370	COG0316	Belongs to the HesB IscA family
E0708_RS22380	COG2050	protein possibly involved in aromatic compounds catabolism
E0708_RS22385	COG0247	lactate metabolic process
E0708_RS22385	COG0277	FAD linked oxidase domain protein
E0708_RS22390	COG0628	permease
E0708_RS22405	COG0738	Major facilitator superfamily
E0708_RS22410	COG2271	Major facilitator Superfamily
E0708_RS22425	COG4670	ketone body catabolic process
E0708_RS22430	COG1960	acyl-CoA dehydrogenase activity
E0708_RS22435	COG2207	Transcriptional regulator
E0708_RS22435	COG1917	Cupin 2, conserved barrel domain protein
E0708_RS22440	COG2086	electron transfer activity
E0708_RS22445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E0708_RS22450	COG0644	oxidoreductase
E0708_RS22455	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E0708_RS22460	COG0318	PFAM AMP-dependent synthetase and ligase
E0708_RS22465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0708_RS22465	COG0574	Belongs to the PEP-utilizing enzyme family
E0708_RS22475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E0708_RS22480	COG4256	Hemin uptake protein
E0708_RS22490	COG2200	EAL domain
E0708_RS22495	COG0791	NLP P60 protein
E0708_RS22505	COG0386	Belongs to the glutathione peroxidase family
E0708_RS22510	COG4139	cobalamin transport
E0708_RS22565	COG3137	Salt-induced outer membrane protein
E0708_RS22570	COG1105	Belongs to the carbohydrate kinase PfkB family
E0708_RS22580	COG3001	Fructosamine kinase
E0708_RS22590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0708_RS22595	COG1988	membrane-bound metal-dependent
E0708_RS22610	COG0753	catalase activity
E0708_RS22615	COG3394	polysaccharide catabolic process
E0708_RS22620	COG1486	melibiose metabolic process
E0708_RS22625	COG2169	Transcriptional regulator
E0708_RS22625	COG1917	Cupin 2, conserved barrel domain protein
E0708_RS22630	COG1447	Phosphotransferase system cellobiose-specific component IIA
E0708_RS22635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E0708_RS22640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E0708_RS22645	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0708_RS22655	COG0322	excinuclease ABC activity
E0708_RS22665	COG3678	ATP-independent chaperone mediated protein folding
E0708_RS22675	COG3724	N-succinylarginine dihydrolase activity
E0708_RS22680	COG1012	belongs to the aldehyde dehydrogenase family
E0708_RS22685	COG3138	arginine N-succinyltransferase
E0708_RS22695	COG0708	Exodeoxyribonuclease III
E0708_RS22700	COG0398	Pfam SNARE associated Golgi protein
E0708_RS22710	COG0398	Pfam SNARE associated Golgi protein
E0708_RS22715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0708_RS22720	COG4134	Bacterial extracellular solute-binding protein
E0708_RS22725	COG4135	transport system, permease component
E0708_RS22730	COG4136	ATPase activity
E0708_RS22735	COG2897	thiosulfate sulfurtransferase activity
E0708_RS22740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E0708_RS22745	COG0494	nUDIX hydrolase
E0708_RS22755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E0708_RS22765	COG0443	Heat shock 70 kDa protein
E0708_RS22775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E0708_RS22780	COG0709	Synthesizes selenophosphate from selenide and ATP
E0708_RS22785	COG0778	Nitroreductase
E0708_RS22790	COG0616	signal peptide processing
E0708_RS22795	COG0252	asparaginase activity
E0708_RS22800	COG1335	isochorismatase
E0708_RS22805	COG2814	Major facilitator Superfamily
E0708_RS22810	COG1349	DNA-binding transcription factor activity
E0708_RS22815	COG0667	Aldo Keto reductase
E0708_RS22820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0708_RS22825	COG0191	fructose-bisphosphate aldolase activity
E0708_RS22830	COG1063	alcohol dehydrogenase
E0708_RS22835	COG2271	Major facilitator Superfamily
E0708_RS22840	COG1063	alcohol dehydrogenase
E0708_RS22845	COG3139	Protein of unknown function (DUF1315)
E0708_RS22855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E0708_RS22860	COG0676	glucose-6-phosphate 1-epimerase activity
E0708_RS22865	COG0656	L-ascorbic acid biosynthetic process
E0708_RS22870	COG3713	MltA-interacting MipA family protein
E0708_RS22875	COG2766	serine protein kinase
E0708_RS22885	COG2199	diguanylate cyclase activity
E0708_RS22890	COG2199	diguanylate cyclase activity
E0708_RS22895	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E0708_RS22910	COG2207	Transcriptional regulator
E0708_RS22915	COG2807	transmembrane transport
E0708_RS22920	COG3189	MarR family transcriptional regulator
E0708_RS22925	COG3042	response to heat
E0708_RS22930	COG2199	diguanylate cyclase activity
E0708_RS22930	COG2203	Gaf domain
E0708_RS22945	COG2261	transglycosylase associated protein
E0708_RS22955	COG3615	Tellurite resistance protein tehB
E0708_RS22965	COG0583	DNA-binding transcription factor activity
E0708_RS22970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E0708_RS22975	COG0318	PFAM AMP-dependent synthetase and ligase
E0708_RS22980	COG3065	identical protein binding
E0708_RS22985	COG1214	PFAM Peptidase M22, glycoprotease
E0708_RS22990	COG1199	ATP-dependent helicase activity
E0708_RS22995	COG0251	oxidation-reduction process
E0708_RS23010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E0708_RS23015	COG0494	nUDIX hydrolase
E0708_RS23020	COG1760	l-serine dehydratase
E0708_RS23025	COG2200	EAL domain
E0708_RS23030	COG1253	flavin adenine dinucleotide binding
E0708_RS23035	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0708_RS23035	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E0708_RS23040	COG3715	PTS system
E0708_RS23045	COG3716	PTS system mannose fructose sorbose family IID component
E0708_RS23060	COG2226	methyltransferase
E0708_RS23090	COG1414	Transcriptional regulator
E0708_RS23095	COG2814	Major facilitator Superfamily
E0708_RS23105	COG0793	Belongs to the peptidase S41A family
E0708_RS23115	COG1956	GAF domain-containing protein
E0708_RS23120	COG2995	paraquat-inducible protein a
E0708_RS23125	COG3008	intermembrane lipid transfer
E0708_RS23130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E0708_RS23130	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E0708_RS23145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E0708_RS23155	COG1276	copper resistance
E0708_RS23160	COG2372	response to copper ion
E0708_RS23170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0708_RS23175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0708_RS23185	COG2979	Protein of unknown function (DUF533)
E0708_RS23195	COG3141	response to X-ray
E0708_RS23205	COG0800	Aldolase
E0708_RS23210	COG0129	dihydroxy-acid dehydratase activity
E0708_RS23215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E0708_RS23220	COG1737	Transcriptional regulator
E0708_RS23225	COG0469	pyruvate kinase activity
E0708_RS23230	COG1560	Kdo2-lipid A biosynthetic process
E0708_RS23235	COG0739	heme binding
E0708_RS23240	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
E0708_RS23250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E0708_RS23280	COG0217	transcriptional regulatory protein
E0708_RS23285	COG0494	nUDIX hydrolase
E0708_RS23295	COG1335	isochorismatase
E0708_RS23300	COG1801	Protein of unknown function DUF72
E0708_RS23305	COG3788	relative of glutathione S-transferase, MAPEG superfamily
E0708_RS23320	COG0243	molybdopterin cofactor binding
E0708_RS23325	COG3005	denitrification pathway
E0708_RS23335	COG3102	Protein conserved in bacteria
E0708_RS23355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E0708_RS23360	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E0708_RS23365	COG0745	RESPONSE REGULATOR receiver
E0708_RS23375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E0708_RS23385	COG0840	transmembrane signaling receptor activity
E0708_RS23390	COG0835	chemotaxis
E0708_RS23395	COG2198	Histidine kinase
E0708_RS23395	COG0643	Histidine kinase
E0708_RS23400	COG1360	Flagellar Motor Protein
E0708_RS23405	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E0708_RS23420	COG0589	response to stress
E0708_RS23430	COG1877	trehalose-phosphatase activity
E0708_RS23435	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0708_RS23440	COG1129	ABC transporter
E0708_RS23445	COG1879	ABC-type sugar transport system periplasmic component
E0708_RS23450	COG1528	Iron-storage protein
E0708_RS23470	COG1528	Iron-storage protein
E0708_RS23480	COG0814	amino acid
E0708_RS23485	COG3318	Belongs to the UPF0149 family
E0708_RS23485	COG3012	SEC-C Motif Domain Protein
E0708_RS23515	COG2197	response regulator
E0708_RS23530	COG2197	response regulator
E0708_RS23545	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E0708_RS23560	COG1191	sigma factor activity
E0708_RS23570	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E0708_RS23575	COG1516	flagellar protein fliS
E0708_RS23585	COG0366	Alpha amylase catalytic
E0708_RS23595	COG2391	methyltransferase activity
E0708_RS23600	COG0425	Belongs to the sulfur carrier protein TusA family
E0708_RS23605	COG2135	peptidase activity
E0708_RS23620	COG2207	Transcriptional regulator
E0708_RS23625	COG1881	PFAM PEBP family protein
E0708_RS23630	COG2076	Multidrug Resistance protein
E0708_RS23640	COG1766	The M ring may be actively involved in energy transduction
E0708_RS23645	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E0708_RS23650	COG1317	bacterial-type flagellum organization
E0708_RS23655	COG1157	protein secretion by the type III secretion system
E0708_RS23660	COG2882	bacterial-type flagellum organization
E0708_RS23665	COG3144	bacterial-type flagellum assembly
E0708_RS23670	COG1580	Controls the rotational direction of flagella during chemotaxis
E0708_RS23675	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E0708_RS23680	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E0708_RS23685	COG3190	flagellar
E0708_RS23690	COG1338	Plays a role in the flagellum-specific transport system
E0708_RS23695	COG1987	bacterial-type flagellum assembly
E0708_RS23700	COG1684	flagellar biosynthetic protein fliR
E0708_RS23705	COG2197	response regulator
E0708_RS23720	COG3769	mannosylglycerate metabolic process
E0708_RS23725	COG3706	GGDEF domain
E0708_RS23730	COG5475	Uncharacterized small protein (DUF2158)
E0708_RS23735	COG2354	Protein conserved in bacteria
E0708_RS23740	COG0697	spore germination
E0708_RS23745	COG3727	T/G mismatch-specific endonuclease activity
E0708_RS23750	COG0270	DNA (cytosine-5-)-methyltransferase activity
E0708_RS23755	COG1418	mRNA catabolic process
E0708_RS23765	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E0708_RS23775	COG2205	protein histidine kinase activity
E0708_RS23780	COG0745	RESPONSE REGULATOR receiver
E0708_RS23785	COG2351	hydroxyisourate hydrolase activity
E0708_RS23790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E0708_RS23795	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E0708_RS23800	COG3443	Belongs to the bacterial solute-binding protein 9 family
E0708_RS23805	COG0582	viral genome integration into host DNA
E0708_RS23945	COG0582	viral genome integration into host DNA
E0708_RS23955	COG2814	Major facilitator Superfamily
E0708_RS23960	COG1132	(ABC) transporter
E0708_RS23975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E0708_RS23975	COG2226	methyltransferase
E0708_RS23975	COG3433	isochorismatase activity
E0708_RS23995	COG1021	2,3-dihydroxybenzoate-AMP ligase
E0708_RS24000	COG4771	TonB-dependent receptor
E0708_RS24005	COG4932	domain protein
E0708_RS24005	COG2373	Large extracellular alpha-helical protein
E0708_RS24005	COG1388	LysM domain
E0708_RS24010	COG1388	LysM domain
E0708_RS24010	COG1470	cell adhesion involved in biofilm formation
E0708_RS24015	COG1388	LysM domain
E0708_RS24015	COG1470	cell adhesion involved in biofilm formation
E0708_RS24025	COG0477	Major facilitator Superfamily
E0708_RS24030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E0708_RS24035	COG0217	transcriptional regulatory protein
E0708_RS24045	COG0583	DNA-binding transcription factor activity
E0708_RS24050	COG0583	DNA-binding transcription factor activity
E0708_RS24060	COG0534	Mate efflux family protein
E0708_RS24070	COG0582	viral genome integration into host DNA
E0708_RS24080	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
E0708_RS24105	COG0154	amidase activity
E0708_RS24325	COG5301	cellulose 1,4-beta-cellobiosidase activity
E0708_RS24420	COG0740	serine-type endopeptidase activity
E0708_RS24445	COG1475	DNA binding
E0708_RS24455	COG1475	DNA binding
E0708_RS24460	COG1475	DNA binding