locus-tag class description HO397_RS00010 ENOG4105CFH Aspartokinase HO397_RS00020 ENOG4105D98 threonine synthase HO397_RS00025 ENOG41062C6 Protein of unknown function (DUF2502) HO397_RS00035 ENOG4105BZG amino acid carrier protein HO397_RS00045 ENOG4108RIR Molybdenum cofactor biosynthesis protein HO397_RS00050 ENOG4106HK8 GPR1 FUN34 yaaH family protein HO397_RS00055 ENOG4108QUJ UPF0174 protein YaaW HO397_RS00075 ENOG4108SER Transposase HO397_RS00080 ENOG4105WI6 cell killing protein encoded within cryptic prophage HO397_RS00090 ENOG41063Z6 transcriptional regulator, lysR family HO397_RS00125 ENOG410647N response to DNA damage stimulus HO397_RS00130 ENOG4105DTN riboflavin biosynthesis protein ribF HO397_RS00135 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HO397_RS00145 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HO397_RS00165 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HO397_RS00170 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HO397_RS00175 ENOG4108XNW Transcriptional activatory protein CaiF HO397_RS00185 ENOG4106YT9 Enoyl-CoA hydratase HO397_RS00205 ENOG4105C94 Transporter HO397_RS00215 ENOG4105C10 Electron transfer flavoprotein HO397_RS00220 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HO397_RS00225 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HO397_RS00230 ENOG4105C54 Major Facilitator superfamily HO397_RS00245 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HO397_RS00250 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HO397_RS00265 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HO397_RS00270 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HO397_RS00275 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HO397_RS00280 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HO397_RS00285 ENOG4105D3G Pseudouridine synthase HO397_RS00290 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HO397_RS00295 ENOG4105CQ2 DNA polymerase HO397_RS00300 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HO397_RS00310 ENOG4105EF1 ribulokinase HO397_RS00315 ENOG41063TF transcriptional regulator (AraC HO397_RS00320 ENOG4108KF1 Membrane HO397_RS00330 ENOG4106SMU thiamine transporter membrane protein HO397_RS00335 ENOG4105DP9 ABC transporter HO397_RS00350 ENOG4105S8Q sugar efflux transporter HO397_RS00365 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HO397_RS00380 ENOG41064T2 transcriptional regulator, lysR family HO397_RS00385 ENOG4105C7K acetolactate synthase HO397_RS00390 ENOG4108ZP8 Acetolactate synthase small subunit HO397_RS00400 ENOG4107B7Y DNA-binding transcriptional regulator FruR HO397_RS00415 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HO397_RS00420 ENOG4105CJN penicillin-binding protein HO397_RS00425 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HO397_RS00430 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HO397_RS00440 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HO397_RS00445 ENOG4105CNI cell division protein FtsW HO397_RS00450 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HO397_RS00460 ENOG4105CPF Cell wall formation (By similarity) HO397_RS00465 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HO397_RS00470 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HO397_RS00475 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HO397_RS00485 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HO397_RS00495 ENOG4105M6F mutator MutT protein HO397_RS00510 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HO397_RS00520 ENOG4105D7Q type ii secretion system HO397_RS00525 ENOG4107QHF type ii secretion system protein e HO397_RS00530 ENOG4108ZUW Major pilin subunit HO397_RS00535 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HO397_RS00540 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HO397_RS00545 ENOG4106A72 regulatory protein AmpE HO397_RS00550 ENOG4105C85 amino acid HO397_RS00555 ENOG41073TP transcriptional regulator HO397_RS00560 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HO397_RS00565 ENOG4107QSN dihydrolipoamide acetyltransferase HO397_RS00570 ENOG4107QN2 dihydrolipoyl dehydrogenase HO397_RS00575 ENOG4108NST exported protein HO397_RS00580 ENOG4107QIJ Aconitate hydratase 2 HO397_RS00600 ENOG4108ZRK uncharacterized protein yacC HO397_RS00605 ENOG4105E3B Multicopper oxidase HO397_RS00610 ENOG4105DZG Dehydrogenase HO397_RS00615 ENOG4108UGV hypoxanthine phosphoribosyltransferase HO397_RS00620 ENOG41077A9 carbonic anhydrase HO397_RS00625 ENOG4105DA5 (ABC) transporter HO397_RS00630 ENOG4105E3A (ABC) transporter HO397_RS00635 ENOG4108YTN IIa component HO397_RS00640 ENOG4107BJW polysaccharide deacetylase HO397_RS00650 ENOG4108A32 Transposase HO397_RS00660 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HO397_RS00665 ENOG4105P0Q fimbrial-like protein YadC HO397_RS00670 ENOG4105SN2 fimbrial-like adhesin protein HO397_RS00675 ENOG4105SYG Fimbrial protein HO397_RS00680 ENOG4108XEY fimbrial-like adhesin protein HO397_RS00685 ENOG4105CW0 outer membrane usher protein HO397_RS00690 ENOG4108VEV chaperone HO397_RS00700 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HO397_RS00705 ENOG4105DJ0 Poly(A) Polymerase HO397_RS00725 ENOG4107XID 2'-5' rna ligase HO397_RS00730 ENOG4105CQ7 ATP-dependent helicase HO397_RS00735 ENOG4105BZ4 penicillin-binding protein HO397_RS00755 ENOG4105E0A ABC, transporter HO397_RS00760 ENOG4105J76 Periplasmic binding protein HO397_RS00765 ENOG4105S6R Iron-hydroxamate transporter permease subunit HO397_RS00770 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HO397_RS00790 ENOG4105EN6 Membrane HO397_RS00795 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HO397_RS00805 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HO397_RS00810 ENOG4105C0H protease HO397_RS00815 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HO397_RS00825 ENOG4105DIN metallophosphoesterase HO397_RS00835 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HO397_RS00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HO397_RS00865 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HO397_RS00870 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HO397_RS00875 ENOG4105KNE Phosphatidate cytidylyltransferase HO397_RS00880 ENOG4105DZP Membrane-associated zinc metalloprotease HO397_RS00890 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HO397_RS00895 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HO397_RS00915 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HO397_RS00920 ENOG4105C0B DNA polymerase III (alpha subunit) HO397_RS00925 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HO397_RS00930 ENOG4105CXN decarboxylase HO397_RS00935 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HO397_RS00940 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HO397_RS00945 ENOG4105M1T rho-binding antiterminator HO397_RS00955 ENOG4108VWS Yaeq family HO397_RS00960 ENOG4108YZN class I peptide chain release factor HO397_RS00965 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HO397_RS00970 ENOG4108UY0 (LipO)protein HO397_RS00980 ENOG4108R96 Methyltransferase, YaeB family HO397_RS00985 ENOG4108R8X outer membrane lipoprotein HO397_RS00990 ENOG4105D01 (LipO)protein HO397_RS00995 ENOG4108UMI ABC transporter, permease HO397_RS01000 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HO397_RS01005 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HO397_RS01040 ENOG4105CV8 reductase HO397_RS01045 ENOG4105HEI LysR family (Transcriptional regulator HO397_RS01060 ENOG4105E9H Lytic Murein transglycosylase HO397_RS01065 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HO397_RS01070 ENOG4105D1A Methyltransferase HO397_RS01080 ENOG4107RZZ dna polymerase iii epsilon subunit HO397_RS01090 ENOG410600K aminopeptidase HO397_RS01105 ENOG410600T transposase HO397_RS01115 ENOG4108WN0 inhibitor of vertebrate lysozyme HO397_RS01120 ENOG4107QPN acyl-Coa dehydrogenase HO397_RS01130 ENOG4105E7A Glutamine amidotransferase HO397_RS01135 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HO397_RS01150 ENOG4108YS0 lipoprotein YafL HO397_RS01155 ENOG4108UK5 Transposase HO397_RS01170 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HO397_RS01175 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system HO397_RS01180 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome HO397_RS01185 ENOG4108HYG acetyltransferase HO397_RS01195 ENOG4108S2Y peptide Chain Release factor HO397_RS01200 ENOG4105CIN aminoacyl-histidine dipeptidase HO397_RS01210 ENOG4105V1F Fermentation respiration switch protein HO397_RS01225 ENOG4105FCK Membrane HO397_RS01250 ENOG4107XAN XdhC and CoxI family HO397_RS01255 ENOG4105C7W Xanthine dehydrogenase HO397_RS01260 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HO397_RS01265 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HO397_RS01270 ENOG4105R3P Inner membrane protein yagU HO397_RS01280 ENOG4105PI0 Ferredoxin HO397_RS01285 ENOG4108UD7 cell wall organization HO397_RS01290 ENOG4106PYX Receptor HO397_RS01295 ENOG4108N3D putative enzyme HO397_RS01310 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HO397_RS01350 ENOG4108KBJ Inner membrane protein YkgB HO397_RS01355 ENOG41066GK UPF0379 protein ykgI HO397_RS01360 ENOG4107QN2 dihydrolipoyl dehydrogenase HO397_RS01365 ENOG4108K01 transcriptional regulator HO397_RS01370 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HO397_RS01375 ENOG4107QR9 Iron-sulfur cluster binding protein HO397_RS01380 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HO397_RS01390 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HO397_RS01405 ENOG4105C94 Transporter HO397_RS01415 ENOG4105BZU Histidine kinase HO397_RS01420 ENOG4108NUU Transcriptional regulator HO397_RS01425 ENOG4105SZ2 membrAne HO397_RS01430 ENOG4107SNB ankyrin repeat protein YahD HO397_RS01435 ENOG4105N16 Protein of unknown function (DUF2877) HO397_RS01440 ENOG4107R1Q Membrane protein FdrA HO397_RS01445 ENOG4107REC cytoplasmic protein HO397_RS01455 ENOG4105C5B carbamate kinase HO397_RS01460 ENOG4105DZC cytosine deaminase HO397_RS01465 ENOG4105DQ4 alcohol dehydrogenase HO397_RS01480 ENOG4105E82 cytochrome subunit of dehydrogenase HO397_RS01485 ENOG4105TDT uncharacterized protein yahO HO397_RS01490 ENOG4108JU7 Transcriptional regulator HO397_RS01495 ENOG4105CR4 methylisocitrate lyase HO397_RS01500 ENOG4105BZN citrate synthase HO397_RS01505 ENOG4105DXD 2-methylcitrate dehydratase HO397_RS01510 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HO397_RS01515 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HO397_RS01520 ENOG4105DZC cytosine deaminase HO397_RS01525 ENOG4105DND Transcriptional regulator HO397_RS01530 ENOG4107B2H carbonic anhydrase HO397_RS01535 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HO397_RS01540 ENOG4105DJ2 Major Facilitator Superfamily HO397_RS01545 ENOG4108UW5 maltose o-acetyltransferase HO397_RS01550 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HO397_RS01555 ENOG4105CNT hydrolase family 2 HO397_RS01560 ENOG4105ETE Transcriptional regulator (LacI family HO397_RS01565 ENOG4108K2P TRANSCRIPTIONal HO397_RS01585 ENOG4105IKQ hydratase HO397_RS01600 ENOG4108SC4 )-transporter HO397_RS01605 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HO397_RS01610 ENOG4105C4W S-formylglutathione hydrolase HO397_RS01625 ENOG4105SRB Uncharacterized protein yaiO HO397_RS01635 ENOG4106FTQ Taurine ABC transporter, periplasmic HO397_RS01640 ENOG4108ETV ABC transporter HO397_RS01645 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HO397_RS01650 ENOG4105E2B Taurine dioxygenase HO397_RS01655 ENOG4105D52 delta-aminolevulinic acid dehydratase HO397_RS01665 ENOG4108PNB DNA-binding transcriptional regulator HO397_RS01670 ENOG4107R6D beta-lactam binding protein AmpH HO397_RS01675 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HO397_RS01680 ENOG4107QS8 (LipO)protein HO397_RS01685 ENOG4105FR5 inner membrane protein YaiY HO397_RS01690 ENOG4105UNH Membrane HO397_RS01695 ENOG4105CPF Cell wall formation (By similarity) HO397_RS01710 ENOG4105G6Z alkaline phosphatase HO397_RS01715 ENOG4105VIF phosphate starvation-inducible protein HO397_RS01720 ENOG4105BZU Histidine kinase HO397_RS01725 ENOG4105II7 pyrroline-5-carboxylate reductase HO397_RS01740 ENOG4105SS3 HO397_RS01745 ENOG4105HBA AroM protein HO397_RS01775 ENOG4105DKQ ROK family HO397_RS01780 ENOG4105F27 Major Facilitator HO397_RS01785 ENOG4105EYH Exonuclease HO397_RS01790 ENOG4107RH8 nuclease SbcCD subunit D HO397_RS01795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HO397_RS01800 ENOG4105BZU Histidine kinase HO397_RS01805 ENOG4105CWM branched-chain amino acid transport system II carrier protein HO397_RS01810 ENOG4105C85 amino acid HO397_RS01815 ENOG4107R28 alpha amylase, catalytic region HO397_RS01820 ENOG4108ZYK Acyl carrier protein phosphodiesterase HO397_RS01835 ENOG4105VIE preprotein translocase, subunit YajC HO397_RS01840 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HO397_RS01845 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HO397_RS01850 ENOG4105N1F Hnh endonuclease HO397_RS01855 ENOG4105DRB nucleoside-specific channel-forming protein HO397_RS01860 ENOG4108KIC (LipO)protein HO397_RS01870 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HO397_RS01875 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HO397_RS01885 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HO397_RS01890 ENOG4108ZAI phosphatidylglycerophosphatase a HO397_RS01895 ENOG4105CPC Aldo Keto reductase HO397_RS01905 ENOG4105CTB Polyprenyl synthetase HO397_RS01920 ENOG4107S0N DJ-1 family HO397_RS01925 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HO397_RS01935 ENOG4107RDB Major Facilitator HO397_RS01960 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HO397_RS01965 ENOG4105CCU oxidase (Subunit III) HO397_RS01970 ENOG4105BZ9 Cytochrome C oxidase, subunit I HO397_RS01975 ENOG4105E2S oxidase) subunit II HO397_RS01980 ENOG4105EYM Major Facilitator superfamily HO397_RS01985 ENOG4105IEY (LipO)protein HO397_RS01990 ENOG4105M85 Bola protein HO397_RS02010 ENOG4108SER Transposase HO397_RS02015 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HO397_RS02020 ENOG4105K70 DNA-binding protein HO397_RS02025 ENOG4105EIN peptidylprolyl cis-trans isomerase HO397_RS02030 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HO397_RS02035 ENOG4108TGP Thioesterase superfamily protein HO397_RS02040 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HO397_RS02045 ENOG4108NFA extracellular solute-binding protein HO397_RS02055 ENOG4108XM1 transcriptional regulator AsnC family HO397_RS02060 ENOG4105BZ1 (ABC) transporter HO397_RS02065 ENOG4105BZ1 (ABC) transporter HO397_RS02070 ENOG4108YZA Nitrogen regulatory protein pii HO397_RS02075 ENOG4105BZU Histidine kinase HO397_RS02080 ENOG4105C29 acyl-CoA thioesterase HO397_RS02085 ENOG4108MNP Glycoprotein polysaccharide metabolism HO397_RS02090 ENOG41080UX Methyltransferase HO397_RS02100 ENOG4105KCV RNA signal recognition particle 4.5S RNA HO397_RS02105 ENOG41066DG (EAL) domain protein HO397_RS02110 ENOG4105GSJ Inner membrane protein ylaC HO397_RS02115 ENOG4108UW5 maltose o-acetyltransferase HO397_RS02120 ENOG4105KF5 hemolysin expression-modulating protein HO397_RS02125 ENOG4108UKR Biofilm formation regulator YbaJ HO397_RS02130 ENOG4105BZS acriflavin resistance protein HO397_RS02135 ENOG4105C1P efflux transporter, rnd family, mfp subunit HO397_RS02140 ENOG4107XI7 Tetr family transcriptional regulator HO397_RS02145 ENOG4105EGS Mechanosensitive ion channel HO397_RS02150 ENOG4106428 Protein of unknown function (DUF2496) HO397_RS02155 ENOG4108URS primosomal replication protein n'' HO397_RS02160 ENOG4105WD1 Membrane HO397_RS02170 ENOG4107QMP dna polymerase iii subunits gamma and tau HO397_RS02205 ENOG4107RE1 Inosine-guanosine kinase HO397_RS02210 ENOG4105CKD glutathione-regulated potassium-efflux system protein HO397_RS02215 ENOG4105EU0 Major facilitator Superfamily HO397_RS02220 ENOG4105CGH 5'-nucleotidase HO397_RS02225 ENOG4108Z66 YbaK ebsC protein HO397_RS02230 ENOG4105MBR gumn family HO397_RS02235 ENOG41081XE plasmid maintenance system antidote protein, xre family HO397_RS02240 ENOG4105C59 p-type ATPase HO397_RS02245 ENOG4105CSV Glutaminase HO397_RS02250 ENOG4107RY6 amino acid HO397_RS02255 ENOG4108Z6Z Transcriptional regulator HO397_RS02260 ENOG4105G5H Membrane HO397_RS02265 ENOG4107QX8 SPFH domain, Band 7 family protein HO397_RS02270 ENOG41083J0 (ABC) transporter HO397_RS02275 ENOG4105C4B ABC transporter, permease HO397_RS02280 ENOG4107QR8 Thioredoxin HO397_RS02285 ENOG4105E1F short-chain dehydrogenase reductase HO397_RS02290 ENOG4108UJV acyl-CoA thioesterase i HO397_RS02295 ENOG4108I0Y (ABC) transporter HO397_RS02300 ENOG4105CV6 ABC transporter, permease HO397_RS02305 ENOG4105CNA YD repeat protein HO397_RS02335 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HO397_RS02340 ENOG4107653 Transcriptional regulator HO397_RS02350 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HO397_RS02355 ENOG41060W2 glyoxylate carboligase HO397_RS02360 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HO397_RS02365 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HO397_RS02370 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HO397_RS02380 ENOG4105DTE Xanthine uracil vitamin C permease HO397_RS02385 ENOG4105BZW Glycerate kinase HO397_RS02390 ENOG4105S0E allantoin catabolism protein HO397_RS02395 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HO397_RS02400 ENOG4105DG4 malate L-lactate dehydrogenase HO397_RS02405 ENOG4107R1Q Membrane protein FdrA HO397_RS02410 ENOG4107REC cytoplasmic protein HO397_RS02415 ENOG4105G5A Protein of unknown function (DUF2877) HO397_RS02420 ENOG4105C5B carbamate kinase HO397_RS02425 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HO397_RS02430 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HO397_RS02440 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HO397_RS02450 ENOG4105S2T inner membrane protein YbcI HO397_RS02455 ENOG4105WQ3 Rna-binding protein HO397_RS02460 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HO397_RS02465 ENOG4108WDE Fimbrial protein HO397_RS02470 ENOG4108AF8 Chaperone HO397_RS02475 ENOG4105CW0 outer membrane usher protein HO397_RS02480 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HO397_RS02485 ENOG4108ZI2 Fimbrial protein HO397_RS02490 ENOG4108Q9V regulatoR HO397_RS02500 ENOG4108KU3 Integrase HO397_RS02530 ENOG410814C multidrug resistance protein HO397_RS02540 ENOG4107TII Recombinase HO397_RS02545 ENOG4108V1U phospholipid-binding protein HO397_RS02550 ENOG4108UQN AraC family transcriptional regulator HO397_RS02560 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HO397_RS02565 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HO397_RS02570 ENOG4105RWQ Protein of unknown function (DUF1364) HO397_RS02585 ENOG4105HRS Antitermination protein HO397_RS02605 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HO397_RS02610 ENOG4105KUS lysozyme HO397_RS02620 ENOG4105QYK bacteriophage lambda Bor protein homolog HO397_RS02625 ENOG4106YSC HO397_RS02655 ENOG4105GR3 Histidine kinase HO397_RS02660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HO397_RS02665 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HO397_RS02670 ENOG410624V efflux system protein HO397_RS02675 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HO397_RS02680 ENOG4108IJF Heavy metal efflux pump, CzcA HO397_RS02685 ENOG4105C85 amino acid HO397_RS02690 ENOG4105CUY Mechanosensitive ion channel HO397_RS02695 ENOG4108RCM Nitroreductase HO397_RS02700 ENOG4105MSB protein, conserved in bacteria HO397_RS02705 ENOG4105WQ6 Membrane HO397_RS02710 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HO397_RS02725 ENOG4105DQ6 Transposase HO397_RS02730 ENOG4107635 Hok Gef family protein HO397_RS02735 ENOG4108SER Transposase HO397_RS02740 ENOG4108TSE Transferase HO397_RS02745 ENOG4107RNH Outer membrane receptor FepA HO397_RS02750 ENOG4105E93 esterase HO397_RS02755 ENOG41085A6 mbth domain-containing protein HO397_RS02760 ENOG4105C0W non-ribosomal peptide synthetase HO397_RS02765 ENOG4108QY5 Ferric enterobactin transport protein HO397_RS02770 ENOG4105E0A ABC, transporter HO397_RS02775 ENOG4105TVJ transport system, permease HO397_RS02780 ENOG4105DQ5 transport system permease protein HO397_RS02790 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HO397_RS02795 ENOG4105E4F Isochorismate synthase HO397_RS02800 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HO397_RS02805 ENOG4105WQI isochorismatase HO397_RS02810 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HO397_RS02815 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HO397_RS02825 ENOG4105VCD cytoplasmic protein HO397_RS02830 ENOG4107SCQ Iron-containing alcohol dehydrogenase HO397_RS02835 ENOG4105CHM Aminotransferase HO397_RS02840 ENOG4105GTN ParB Domain Protein Nuclease HO397_RS02855 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HO397_RS02860 ENOG4105D3R alkyl hydroperoxide reductase HO397_RS02865 ENOG4108JU3 Alkyl hydroperoxide reductase HO397_RS02870 ENOG4108U51 Universal stress protein HO397_RS02875 ENOG4105E2A Dehydrogenase HO397_RS02880 ENOG4105NXH GreA GreB family elongation factor HO397_RS02885 ENOG4105KTS ribonuclease HO397_RS02890 ENOG4107QPK )-transporter HO397_RS02905 ENOG4105CHY citrate lyase, alpha HO397_RS02910 ENOG4105CI0 Citrate lyase HO397_RS02920 ENOG4105DUA (citrate (pro-3S)-lyase ligase HO397_RS02930 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HO397_RS02935 ENOG4106YYS transcriptional regulatory protein HO397_RS02940 ENOG4105CEE C4-dicarboxylate transporter HO397_RS02945 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HO397_RS02965 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HO397_RS02975 ENOG41064T2 transcriptional regulator, lysR family HO397_RS02990 ENOG4105DZ1 carboxypeptidase HO397_RS02995 ENOG4105K6T rare lipoprotein A HO397_RS03000 ENOG4105CNI cell division protein FtsW HO397_RS03005 ENOG4105CJN penicillin-binding protein HO397_RS03015 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HO397_RS03020 ENOG4108TGR phosphatase HO397_RS03030 ENOG4105DJF DNA polymerase III, delta' subunit HO397_RS03045 ENOG4107PAI alpha helical protein HO397_RS03055 ENOG41069CF Protein of unknown function (DUF1266) HO397_RS03065 ENOG4105F7F Chaperone HO397_RS03090 ENOG4105DRP amino acid AbC transporter HO397_RS03095 ENOG4105EAD ABC transporter HO397_RS03100 ENOG4107RP9 extracellular solute-binding protein, family 3 HO397_RS03105 ENOG4107U91 Rhomboid family HO397_RS03110 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HO397_RS03115 ENOG4108JU5 Magnesium and cobalt efflux protein HO397_RS03125 ENOG4105C9A Phoh family HO397_RS03135 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HO397_RS03175 ENOG4105CAQ asparagine synthetase HO397_RS03180 ENOG4105D4U had-superfamily hydrolase, subfamily iia HO397_RS03185 ENOG4105E2R ROK family HO397_RS03190 ENOG4105CE4 GlcNAc 6-P deacetylase HO397_RS03200 ENOG4105CI1 PTS System HO397_RS03215 ENOG4105GX6 (LipO)protein HO397_RS03220 ENOG41090R7 Ferric uptake HO397_RS03230 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HO397_RS03235 ENOG4105NNH LexA regulated protein HO397_RS03240 ENOG4105EV9 Alpha Beta Hydrolase HO397_RS03245 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HO397_RS03250 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HO397_RS03270 ENOG4105D5Q Arginine ornithine antiporter HO397_RS03275 ENOG4105CXN decarboxylase HO397_RS03285 ENOG4105EEX Two component transcriptional regulator (Winged helix family HO397_RS03290 ENOG4105C08 Histidine kinase HO397_RS03315 ENOG4105XIQ Protein of unknown function (DUF2517) HO397_RS03330 ENOG41079JQ Membrane HO397_RS03335 ENOG4105CNA YD repeat protein HO397_RS03340 ENOG4106R09 HO397_RS03365 ENOG4107SEY Conserved Protein HO397_RS03370 ENOG4105CVP deoxyribo-dipyrimidine photolyase HO397_RS03375 ENOG4105DUX Transporter HO397_RS03380 ENOG4107QNR UPF0135 protein HO397_RS03385 ENOG4105P4J Allophanate hydrolase, subunit 1 HO397_RS03390 ENOG4107R7A Allophanate hydrolase subunit 2 HO397_RS03395 ENOG4105E7W lamb ycsf family protein HO397_RS03405 ENOG4108KK1 membrane protein AbrB duplication HO397_RS03410 ENOG4108MY7 Fimbrial HO397_RS03415 ENOG4108TTM chaperone HO397_RS03420 ENOG4106PG1 outer membrane usher protein HO397_RS03425 ENOG4106UBK fimbrial-like adhesin protein HO397_RS03430 ENOG4105BZN citrate synthase HO397_RS03440 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HO397_RS03445 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HO397_RS03450 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HO397_RS03455 ENOG4105E33 succinate dehydrogenase HO397_RS03460 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HO397_RS03465 ENOG4105C7S Dehydrogenase HO397_RS03475 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HO397_RS03480 ENOG4105FDP GntR family transcriptional regulator HO397_RS03485 ENOG4105DM4 PTS System HO397_RS03490 ENOG4105C8I hydrolase, family 38 HO397_RS03500 ENOG4105C4M (Ubiquinol oxidase) subunit I HO397_RS03505 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HO397_RS03515 ENOG4105KJB cyd operon protein YbgE HO397_RS03520 ENOG4107YD3 Thioesterase HO397_RS03525 ENOG4105E02 MotA TolQ exbB proton channel HO397_RS03535 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HO397_RS03545 ENOG4105KCK Peptidoglycan-associated lipoprotein HO397_RS03550 ENOG4105UFD tol-pal system protein YbgF HO397_RS03590 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HO397_RS03595 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HO397_RS03600 ENOG4105PGM cation diffusion facilitator family transporter HO397_RS03605 ENOG4105JND homeobox protein HO397_RS03610 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HO397_RS03625 ENOG4105NBR Pectinesterase HO397_RS03630 ENOG4108I1J Integrase HO397_RS03675 ENOG4108TFU terminase (Small subunit) HO397_RS03680 ENOG4108N0N Phage Terminase Large Subunit HO397_RS03725 ENOG4108V1U phospholipid-binding protein HO397_RS03730 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HO397_RS03745 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HO397_RS03750 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HO397_RS03760 ENOG4105CHW UPF0052 protein HO397_RS03770 ENOG4108RIR Molybdenum cofactor biosynthesis protein HO397_RS03780 ENOG4105M00 molybdopterin converting factor, subunit 1 HO397_RS03785 ENOG4108ZAF Molybdopterin HO397_RS03790 ENOG4105HFZ Membrane HO397_RS03795 ENOG410733J conserved inner membrane protein HO397_RS03800 ENOG4107UXM Membrane HO397_RS03805 ENOG4105DZQ phospholipase D Transphosphatidylase HO397_RS03810 ENOG4105X23 Endonuclease Exonuclease phosphatase HO397_RS03815 ENOG4105I9U inner membrane protein ybhQ HO397_RS03820 ENOG4107QWP ABC-2 type transporter HO397_RS03825 ENOG4107QWP ABC-2 type transporter HO397_RS03830 ENOG4105CJ1 ABC, transporter HO397_RS03840 ENOG4107MVR Transcriptional regulator HO397_RS03845 ENOG4105C1J atp-dependent rna helicase HO397_RS03850 ENOG4108UV1 cellular component movement HO397_RS03855 ENOG4105DVT helicase HO397_RS03860 ENOG4108MTB glycosyl transferase family HO397_RS03865 ENOG4105DG4 malate L-lactate dehydrogenase HO397_RS03870 ENOG4105VR4 UPF0379 protein ybiJ HO397_RS03875 ENOG4105KSC Transcriptional regulator, TraR DksA family HO397_RS03885 ENOG4108IU3 tonb-dependent siderophore receptor HO397_RS03890 ENOG4105ZY9 UPF0379 protein ybiM HO397_RS03900 ENOG4105D8X mechanosensitive ion channel HO397_RS03905 ENOG4105CDA abc transporter atp-binding protein HO397_RS03910 ENOG4105E5Q amino acid AbC transporter HO397_RS03915 ENOG4107R0W ABC transporter HO397_RS03925 ENOG4107AQZ Membrane HO397_RS03935 ENOG4108T1M outer membrane protein x HO397_RS03940 ENOG4108I6E Sulfatase HO397_RS03950 ENOG4105KST dependent repressor HO397_RS03955 ENOG4105F4P )-transporter HO397_RS03960 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HO397_RS03965 ENOG4105C5H ABC transporter HO397_RS03970 ENOG41072TH Protein of unknown function (DUF1479) HO397_RS03975 ENOG4108HCJ Hydrolase HO397_RS03985 ENOG4105F1A Pyruvate formate-lyase HO397_RS03990 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HO397_RS03995 ENOG4105D06 uba thif-type nad fad binding protein HO397_RS04000 ENOG4105CVM Molybdenum cofactor synthesis domain protein HO397_RS04005 ENOG4105D44 asparaginase HO397_RS04010 ENOG4108JQ6 ABC transporter HO397_RS04015 ENOG4105DEF Extracellular solute-binding protein, family 5 HO397_RS04025 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HO397_RS04035 ENOG41064RH membrane protein YliF HO397_RS04045 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HO397_RS04050 ENOG4105D8V Glucose sorbosone dehydrogenase HO397_RS04055 ENOG4108TGY Glutathione S-transferase HO397_RS04060 ENOG4105DZ1 carboxypeptidase HO397_RS04065 ENOG4107FB0 transcriptional regulator DeoR family HO397_RS04070 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HO397_RS04075 ENOG4107QF7 multi-drug HO397_RS04085 ENOG4108HCJ Hydrolase HO397_RS04090 ENOG4106UW1 Major Facilitator superfamily HO397_RS04095 ENOG4108RFG Tetr family transcriptional regulator HO397_RS04105 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HO397_RS04110 ENOG4105UPP uncharacterized protein ydcA HO397_RS04120 ENOG4105MEH HO397_RS04150 ENOG4107RRE RNA-directed DNA polymerase HO397_RS04155 ENOG4105ED4 portal protein HO397_RS04220 ENOG4105PTU response to oxidative stress HO397_RS04225 ENOG4108US3 tail fiber assembly HO397_RS04245 ENOG4105ZTC transcriptional activator, Ogr delta HO397_RS04255 ENOG4105GWF inner membrane protein YbjM HO397_RS04260 ENOG41090BQ Glutaredoxin HO397_RS04265 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HO397_RS04270 ENOG4108DBC nitroreductase HO397_RS04280 ENOG4108RMJ sensory transduction regulator HO397_RS04285 ENOG4107RUE extracellular solute-binding protein family 1 HO397_RS04290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HO397_RS04295 ENOG4105F38 ABC transporter, permease HO397_RS04300 ENOG4105D38 putrescine abc transporter HO397_RS04305 ENOG4105RBQ inner membrane protein ybjO HO397_RS04315 ENOG4106TNF Periplasmic binding protein HO397_RS04320 ENOG4105DMR ABC, transporter HO397_RS04325 ENOG4105GBT ABC transporter HO397_RS04330 ENOG4106PMH Extracellular solute-binding protein family 3 HO397_RS04335 ENOG4105E5Z arginine transporter ATP-binding subunit HO397_RS04340 ENOG41064MM (LipO)protein HO397_RS04350 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HO397_RS04355 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HO397_RS04360 ENOG4105CGD Nad-dependent epimerase dehydratase HO397_RS04365 ENOG4105C5W Aldolase HO397_RS04370 ENOG4105C7K acetolactate synthase HO397_RS04375 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HO397_RS04385 ENOG4105DWU Membrane HO397_RS04390 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HO397_RS04395 ENOG4105CPB ATP-dependent endonuclease of the OLD family HO397_RS04400 ENOG4108MJ5 VirK protein HO397_RS04405 ENOG4105DJY efflux transporter, rnd family, mfp subunit HO397_RS04410 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HO397_RS04415 ENOG4105VEQ Cold shock protein HO397_RS04425 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HO397_RS04440 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HO397_RS04450 ENOG4108JJ8 (ABC) transporter HO397_RS04455 ENOG4108JJ9 ABC, transporter HO397_RS04460 ENOG4105C3M thioredoxin reductase HO397_RS04470 ENOG4105CNU cell division protein FtsK HO397_RS04480 ENOG4105D1H recombination factor protein RarA HO397_RS04490 ENOG4107QY8 reductase HO397_RS04495 ENOG4105QAX Iron-sulfur HO397_RS04500 ENOG4107KGK dmso reductase anchor subunit HO397_RS04505 ENOG4105CHJ isochorismatase hydrolase HO397_RS04515 ENOG4105E5D amino acid HO397_RS04520 ENOG410642W LysR family Transcriptional regulator HO397_RS04525 ENOG4108X0B nad(p)h dehydrogenase (quinone) HO397_RS04530 ENOG4105F1A Pyruvate formate-lyase HO397_RS04535 ENOG4105C6N Formate acetyltransferase HO397_RS04540 ENOG4105TMB Formate nitrite transporter HO397_RS04545 ENOG4105DDY UPF0142 protein ycaO HO397_RS04550 ENOG4107VMU Membrane HO397_RS04565 ENOG4108K0D peptidase, M48 HO397_RS04575 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HO397_RS04585 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HO397_RS04590 ENOG4105BZ1 (ABC) transporter HO397_RS04595 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HO397_RS04600 ENOG4105T0Z Conserved Protein HO397_RS04615 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HO397_RS04620 ENOG4107S90 membrAne HO397_RS04625 ENOG4106371 Methyltransferase HO397_RS04635 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HO397_RS04640 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HO397_RS04645 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HO397_RS04650 ENOG4105EAQ (twin-arginine translocation) pathway signal HO397_RS04655 ENOG4105C5X domain protein HO397_RS04660 ENOG4105CGF Aromatic amino acid aminotransferase HO397_RS04665 ENOG4105FCK Membrane HO397_RS04680 ENOG4105CD8 aminopeptidase N HO397_RS04685 ENOG4105E2Y ABC, transporter HO397_RS04690 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HO397_RS04700 ENOG4105GVF (ABC) transporter HO397_RS04705 ENOG4108UZX fmn reductase HO397_RS04710 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HO397_RS04715 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HO397_RS04720 ENOG4105CW0 outer membrane usher protein HO397_RS04725 ENOG4108MDY Fimbrial HO397_RS04730 ENOG4105Q7J Fimbrial HO397_RS04735 ENOG4105MX3 Fimbrial HO397_RS04740 ENOG4106PH7 chaperone HO397_RS04750 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HO397_RS04755 ENOG4105QVC MOSC domain-containing protein HO397_RS04765 ENOG4105C5H ABC transporter HO397_RS04770 ENOG4105F1S paraquat-inducible protein a HO397_RS04775 ENOG4105DY2 Paraquat-inducible protein b HO397_RS04780 ENOG4108Q2G (LipO)protein HO397_RS04785 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HO397_RS04795 ENOG4105DAN ATP-dependent protease HO397_RS04805 ENOG4105UYK outer membrane protein a HO397_RS04815 ENOG4108RZ1 DNA transformation protein HO397_RS04820 ENOG4105EM2 membrane HO397_RS04825 ENOG410901E Membrane HO397_RS04830 ENOG41088T4 Helicase IV HO397_RS04845 ENOG4105K4P CoA-binding domain protein HO397_RS04860 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HO397_RS04870 ENOG4108MN8 Membrane HO397_RS04880 ENOG4105E3S small subunit HO397_RS04885 ENOG4105DPX Hydrogenase, large subunit HO397_RS04890 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HO397_RS04895 ENOG4108USZ hydrogenase HO397_RS04900 ENOG4108VXY Hydrogenase-1 operon protein HyaE HO397_RS04905 ENOG4105MVP hydrogenase-1 operon protein HyaF HO397_RS04910 ENOG4105C4M (Ubiquinol oxidase) subunit I HO397_RS04915 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HO397_RS04925 ENOG4105D6F Phosphatase HO397_RS04930 ENOG4108F2G Chain length determinant protein HO397_RS04935 ENOG4107ZF2 Phosphatase HO397_RS04940 ENOG4105DAY polysaccharide export protein HO397_RS04945 ENOG4105E3R (LipO)protein HO397_RS04950 ENOG4108W78 Pfam:DUF1017 HO397_RS04955 ENOG4108Y9B (LipO)protein HO397_RS04965 ENOG41060EU Cold shock-like protein HO397_RS04970 ENOG4105VEQ Cold shock protein HO397_RS04985 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HO397_RS04990 ENOG4105HEE Binding Domain protein HO397_RS04995 ENOG4105BZU Histidine kinase HO397_RS05000 ENOG4108SV3 Tmao reductase system periplasmic protein tort HO397_RS05005 ENOG4106WF9 DNA-binding transcriptional regulator TorR HO397_RS05010 ENOG4105CUW cytochrome C-TYPE protein HO397_RS05015 ENOG4107QY8 reductase HO397_RS05040 ENOG4105D6F Phosphatase HO397_RS05045 ENOG4105XH3 HO397_RS05055 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HO397_RS05060 ENOG4105C2W permease HO397_RS05075 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HO397_RS05085 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HO397_RS05095 ENOG4108R86 Transcriptional regulator HO397_RS05100 ENOG4105C26 Dehydrogenase HO397_RS05110 ENOG4105CK7 Sodium proline symporter HO397_RS05125 ENOG410650H (LipO)protein HO397_RS05130 ENOG4105DBE peroxidase HO397_RS05135 ENOG4105D5M phosphate starvation-inducible protein HO397_RS05145 ENOG4105CND Glycosyl transferase, family 2 HO397_RS05150 ENOG4107BJW polysaccharide deacetylase HO397_RS05155 ENOG4108TUY outer membrane protein PgaA HO397_RS05160 ENOG4105BZU Histidine kinase HO397_RS05185 ENOG4107XHZ cytoplasmic chaperone TorD family protein HO397_RS05190 ENOG4108UQ5 membrane protein YcdZ HO397_RS05195 ENOG4105P8Q Curli production assembly transport component CsgG HO397_RS05200 ENOG4108WYR Curli production assembly transport component, CsgF HO397_RS05205 ENOG4108XDW curli assembly protein CsgE HO397_RS05210 ENOG41086KC Transcriptional regulator HO397_RS05215 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HO397_RS05220 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HO397_RS05235 ENOG4108UVJ appr-1-p processing domain protein HO397_RS05240 ENOG4107RZC phospholipase d HO397_RS05245 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HO397_RS05250 ENOG4105DJ9 glucan biosynthesis protein HO397_RS05255 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HO397_RS05260 ENOG4105NAC (LipO)protein HO397_RS05265 ENOG4108W47 Acidic protein msyB HO397_RS05275 ENOG4105D1S lipid A biosynthesis HO397_RS05280 ENOG4105C72 UPF0176 protein HO397_RS05285 ENOG4108YYC ycei family HO397_RS05290 ENOG4105DS1 cytochrome b561 HO397_RS05295 ENOG4106974 biofilm formation HO397_RS05300 ENOG4105F76 Sarcosine oxidase HO397_RS05305 ENOG4105PVA Biofilm formation regulatory protein BssS HO397_RS05310 ENOG4105MEA DNA damage-inducible protein i HO397_RS05320 ENOG4105F3T (LipO)protein HO397_RS05325 ENOG4105E9S glutaredoxin 2 HO397_RS05335 ENOG4105D9U N-acetyltransferase HO397_RS05340 ENOG4108YXG UPF0502 protein HO397_RS05345 ENOG4105EP9 oxidoreductase HO397_RS05350 ENOG4105CJR Integral membrane protein (MviN HO397_RS05355 ENOG4105QVD Flagella synthesis protein FlgN HO397_RS05360 ENOG4105M9M anti-sigma28 factor FlgM HO397_RS05365 ENOG4105CKS Flagella basal body P-ring formation protein flgA HO397_RS05370 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HO397_RS05375 ENOG4108ZC9 flagellar basal-body rod protein flgc HO397_RS05380 ENOG4105W00 Flagellar hook capping protein HO397_RS05385 ENOG4105BZE flagellar hook protein, FlgE HO397_RS05390 ENOG4108KPB Flagellar basal-body rod protein FlgF HO397_RS05395 ENOG4105CGA flagellar basal-body rod protein FlgG HO397_RS05410 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HO397_RS05415 ENOG4105E1Q flagellar hook-associated protein HO397_RS05420 ENOG4105DTJ flagellar hook-associated protein HO397_RS05425 ENOG4107QQB Ribonuclease E HO397_RS05430 ENOG4105EI2 Pseudouridine synthase HO397_RS05435 ENOG4108UHJ MAF-like protein HO397_RS05440 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HO397_RS05460 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HO397_RS05465 ENOG4105CHR reductase HO397_RS05470 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HO397_RS05475 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HO397_RS05480 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HO397_RS05485 ENOG4105HHA aminodeoxychorismate lyase HO397_RS05495 ENOG4107QRG dna polymerase iii HO397_RS05500 ENOG4105F8V Hydrolase, tatD family HO397_RS05505 ENOG4105CI1 PTS System HO397_RS05510 ENOG4105CNM Receptor HO397_RS05515 ENOG4105K59 histidine triad (HIT) protein HO397_RS05520 ENOG41090DQ Lipoprotein HO397_RS05525 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HO397_RS05545 ENOG4105CEP NADH dehydrogenase HO397_RS05550 ENOG4107MBR 17 kDa surface antigen HO397_RS05555 ENOG4108IND Tetr family transcriptional regulator HO397_RS05560 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HO397_RS05565 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HO397_RS05570 ENOG4108JA2 transcriptioN-repair coupling factor HO397_RS05575 ENOG4105IQC Inner membrane protein YcfT HO397_RS05580 ENOG4105D60 lipoprotein releasing system transmembrane protein HO397_RS05585 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HO397_RS05590 ENOG4105D60 lipoprotein releasing system transmembrane protein HO397_RS05610 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HO397_RS05625 ENOG4107RUE extracellular solute-binding protein family 1 HO397_RS05630 ENOG4105D38 putrescine abc transporter HO397_RS05650 ENOG4105EZE Cupin 4 family protein HO397_RS05655 ENOG4105IFJ Histidine kinase HO397_RS05660 ENOG4105XJC Two component transcriptional regulator (Winged helix family HO397_RS05665 ENOG4107QTF adenylosuccinate lyase HO397_RS05685 ENOG4108R99 pseudouridine synthase HO397_RS05690 ENOG4108HMX isocitrate dehydrogenase (NADP) HO397_RS05705 ENOG41064WM Uncharacterized protein YcgX HO397_RS05710 ENOG4108XDN Transcriptional regulator HO397_RS05715 ENOG4105BZU Histidine kinase HO397_RS05720 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HO397_RS05725 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HO397_RS05735 ENOG410738I uncharacterized protein ymgC HO397_RS05740 ENOG4105BZU Histidine kinase HO397_RS05755 ENOG410658X HO397_RS05790 ENOG4107QMS site-determining protein HO397_RS05795 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HO397_RS05800 ENOG4105S66 prophage protein HO397_RS05805 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HO397_RS05815 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HO397_RS05830 ENOG4105KT5 UmuD protein HO397_RS05835 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HO397_RS05840 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HO397_RS05855 ENOG4105ED1 spovr family HO397_RS05865 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HO397_RS05875 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HO397_RS05880 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HO397_RS05885 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HO397_RS05905 ENOG4105VDH Dihydroxyacetone kinase HO397_RS05910 ENOG4108UTZ Dihydroxyacetone kinase HO397_RS05915 ENOG4105CMT Dihydroxyacetone kinase HO397_RS05920 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HO397_RS05925 ENOG4105I1J Autotransporter HO397_RS05930 ENOG4105C3G gtp-binding protein HO397_RS05940 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HO397_RS05945 ENOG4105CHH sulfate transporter HO397_RS05950 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HO397_RS05975 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HO397_RS05980 ENOG4108YY7 Invasion gene expression up-regulator SirB HO397_RS05985 ENOG41063JG Transcriptional regulator HO397_RS06010 ENOG4105EWV Sodium calcium exchanger membrane region HO397_RS06015 ENOG4105WS7 Cation transport regulator HO397_RS06020 ENOG4108NH8 Cation transport protein HO397_RS06025 ENOG41090EX DsrE family HO397_RS06030 ENOG4105ID0 Putative invasin HO397_RS06035 ENOG4105WH1 Two component transcriptional regulator luxr family HO397_RS06040 ENOG4105BZU Histidine kinase HO397_RS06045 ENOG4105DQQ Major facilitator superfamily MFS_1 HO397_RS06050 ENOG4105CRU nitrate reductase, alpha subunit HO397_RS06055 ENOG4108IUE nitrate reductase beta subunit HO397_RS06060 ENOG4105R3A Nitrate reductase HO397_RS06065 ENOG41076YT nitrate reductase, gamma subunit HO397_RS06090 ENOG4105CIY formyltetrahydrofolate deformylase HO397_RS06100 ENOG4105D78 K07001 NTE family protein HO397_RS06105 ENOG4105I93 response regulator HO397_RS06110 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HO397_RS06115 ENOG4108SAU DNA-binding protein H-ns HO397_RS06120 ENOG4107104 thymidine kinase HO397_RS06125 ENOG4105C0A alcohol dehydrogenase HO397_RS06130 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HO397_RS06135 ENOG4108J59 Extracellular solute-binding protein, family 5 HO397_RS06140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HO397_RS06145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HO397_RS06150 ENOG4105C3U ABC transporter HO397_RS06155 ENOG4108JQ7 (ABC) transporter HO397_RS06175 ENOG4107SVH Potassium channel protein HO397_RS06180 ENOG4105K9H YciI-like protein HO397_RS06185 ENOG410822N TonB family HO397_RS06190 ENOG4105NAU thioesterase Superfamily protein HO397_RS06210 ENOG4105EIF outer membrane protein W HO397_RS06215 ENOG4108N8X transition metal ion binding HO397_RS06220 ENOG4108Z9Z response to DNA damage stimulus HO397_RS06240 ENOG4105DK0 Indole-3-glycerol phosphate synthase HO397_RS06245 ENOG4108EFP Anthranilate synthase component II HO397_RS06250 ENOG4105CRQ synthase (Component I) HO397_RS06260 ENOG4105DB7 PHP domain protein HO397_RS06265 ENOG4107RTD sua5 ycio yrdc ywlc family protein HO397_RS06285 ENOG4105FE9 pseudouridine synthase HO397_RS06290 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HO397_RS06295 ENOG4105UBK short-chain dehydrogenase reductase HO397_RS06300 ENOG4105ERU peptidase HO397_RS06305 ENOG4105RKX Protein of unknown function (DUF2498) HO397_RS06310 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HO397_RS06315 ENOG4107R11 Transcriptional regulator HO397_RS06335 ENOG4107QM5 aconitate hydratase HO397_RS06345 ENOG4105EYK Phosphatidylglycerophosphatase B HO397_RS06350 ENOG4105Q4A inner membrane protein yciS HO397_RS06355 ENOG4105CFV Tetratricopeptide repeat protein HO397_RS06365 ENOG4108ZJT translation initiation factor, Sui1 HO397_RS06375 ENOG4105N2W Transcriptional regulator HO397_RS06380 ENOG410643D UPF0509 protein HO397_RS06385 ENOG4105BZU Histidine kinase HO397_RS06400 ENOG4105Q4T oxidoreductase HO397_RS06405 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HO397_RS06410 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HO397_RS06415 ENOG4108JQ2 peptide transport system atp-binding protein HO397_RS06420 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HO397_RS06425 ENOG4108EU3 peptide transport system, permease HO397_RS06430 ENOG4108I5W peptide transport system, permease protein HO397_RS06435 ENOG4108HIY periplasmic HO397_RS06440 ENOG4105N0E Protein of unknown function (DUF2543) HO397_RS06445 ENOG4105CUB amino acid HO397_RS06455 ENOG4105CFQ glutamine synthetase HO397_RS06460 ENOG4108Z86 Glutamine amidotransferase HO397_RS06465 ENOG4107VRI Transcriptional regulator HO397_RS06470 ENOG4105C26 Dehydrogenase HO397_RS06475 ENOG4105CJP fad dependent oxidoreductase HO397_RS06480 ENOG4108JPW Aminotransferase HO397_RS06485 ENOG4105E51 psp operon transcriptional activator HO397_RS06490 ENOG41087YS Phage shock protein A HO397_RS06495 ENOG4105YYT phage shock protein B HO397_RS06500 ENOG4105FM1 phage shock protein C HO397_RS06505 ENOG4105NNG Peripheral inner membrane phage-shock protein HO397_RS06510 ENOG4105K8Z Phage shock protein HO397_RS06515 ENOG4107QW3 Sucrose phosphorylase HO397_RS06520 ENOG4105WEM extracellular solute-binding protein HO397_RS06525 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HO397_RS06530 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HO397_RS06535 ENOG4107RRD Dehydrogenase HO397_RS06540 ENOG4107TYA transient receptor potential locus HO397_RS06545 ENOG4105CK5 oxidoreductase HO397_RS06550 ENOG4105C71 hydrolase family 65, central catalytic HO397_RS06555 ENOG4107URF beta-phospho-glucomutase HO397_RS06560 ENOG4108IJ9 (ABC) transporter HO397_RS06565 ENOG4107EFV Outer membrane protein G HO397_RS06570 ENOG4105FKQ transcriptional regulator HO397_RS06575 ENOG4105CM6 amino acid regulated cytosolic protein HO397_RS06585 ENOG4108JU8 Transcriptional regulator HO397_RS06590 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HO397_RS06595 ENOG4107S8C mandelate racemase muconate lactonizing HO397_RS06600 ENOG4105KXI murein peptide amidase A HO397_RS06615 ENOG4105ENX hydrolase HO397_RS06620 ENOG4105EQ2 LysR family Transcriptional regulator HO397_RS06625 ENOG4107QSI ABC, transporter HO397_RS06630 ENOG4105D64 Mechanosensitive ion channel HO397_RS06635 ENOG4105S5I Membrane HO397_RS06640 ENOG4105Q9Y Universal stress protein HO397_RS06650 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HO397_RS06655 ENOG4105CFC Transporter HO397_RS06660 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HO397_RS06665 ENOG4105CH2 amidohydrolase HO397_RS06670 ENOG4106KR7 LysR family Transcriptional regulator HO397_RS06675 ENOG4108DG9 Smr protein MutS2 HO397_RS06680 ENOG4105BZU Histidine kinase HO397_RS06690 ENOG4105C1J atp-dependent rna helicase HO397_RS06700 ENOG4107R08 Integrase HO397_RS06705 ENOG4107160 Rac prophage HO397_RS06710 ENOG41070YT Rac prophage HO397_RS06715 ENOG4106YAH restriction alleviation and modification enhancement HO397_RS06720 ENOG4108PNI recT protein HO397_RS06735 ENOG4107C82 Rac prophage HO397_RS06755 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HO397_RS06780 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HO397_RS06785 ENOG4108ES9 ParB domain protein nuclease HO397_RS06810 ENOG4105MN3 Resolvase HO397_RS06815 ENOG4105W3V DNA-binding, transcriptional regulator HO397_RS06830 ENOG4108RW8 Universal stress protein F HO397_RS06835 ENOG4105FCK Membrane HO397_RS06840 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HO397_RS06845 ENOG4105IKK cytoplasmic protein HO397_RS06850 ENOG41090X5 Heat shock protein hslJ HO397_RS06855 ENOG4105C5I Dehydrogenase HO397_RS06860 ENOG4107H52 Dicarboxylate transport HO397_RS06865 ENOG410689M (LipO)protein HO397_RS06870 ENOG4105WXT Conserved Protein HO397_RS06875 ENOG4108WFR AraC Family Transcriptional Regulator HO397_RS06880 ENOG4105C26 Dehydrogenase HO397_RS06905 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HO397_RS06910 ENOG4108HPI phosphatidate Cytidylyltransferase HO397_RS06915 ENOG4105E8V Alpha Beta Hydrolase Fold protein HO397_RS06920 ENOG41077RS Phosphatase HO397_RS06930 ENOG4105CQ7 ATP-dependent helicase HO397_RS06935 ENOG4107DB1 DUF218 domain HO397_RS06940 ENOG4105C26 Dehydrogenase HO397_RS06945 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HO397_RS06955 ENOG4105CPW cytochrome b561 HO397_RS06960 ENOG4105UPP uncharacterized protein ydcA HO397_RS06965 ENOG4107NK6 Hok/gef family HO397_RS06970 ENOG4105C8Q Methyl-accepting chemotaxis HO397_RS06975 ENOG4105DDW LysR family Transcriptional regulator HO397_RS06980 ENOG4105E32 cytoplasmic protein HO397_RS06985 ENOG4105DJ9 glucan biosynthesis protein HO397_RS06990 ENOG4105Z2P Protein of unknown function (DUF465) HO397_RS06995 ENOG4108Z9I -acetyltransferase HO397_RS07000 ENOG4107WE3 acetyltransferase YdcK HO397_RS07005 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HO397_RS07010 ENOG41088CC tellurite resistance protein tehB HO397_RS07015 ENOG4108KKZ (LipO)protein HO397_RS07025 ENOG4105D7V transposase HO397_RS07030 ENOG4105DKK Benzoate HO397_RS07035 ENOG4108JCI Transcriptional regulator HO397_RS07040 ENOG4105CFP Peptidase U32 HO397_RS07045 ENOG4105RR0 Protein of unknown function (DUF2554) HO397_RS07055 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HO397_RS07060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HO397_RS07065 ENOG4107TYH extracellular solute-binding protein family 1 HO397_RS07070 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HO397_RS07075 ENOG4105D81 ABC transporter, permease HO397_RS07080 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HO397_RS07095 ENOG410654E Membrane HO397_RS07100 ENOG4105R71 cytoplasmic protein HO397_RS07105 ENOG4108T9Y Inner membrane protein ydcZ HO397_RS07110 ENOG4108Z7F N-acetyltransferase HO397_RS07115 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HO397_RS07120 ENOG4108WYP Transcriptional regulator HO397_RS07125 ENOG4105CHB tonB-dependent Receptor HO397_RS07130 ENOG4108NS2 receptor HO397_RS07135 ENOG4105C85 amino acid HO397_RS07140 ENOG4108N27 Glutathione S-transferase HO397_RS07185 ENOG4108MEJ flavin reductase domain protein HO397_RS07190 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HO397_RS07200 ENOG4105D0D Nitrate reductase 2, gamma subunit HO397_RS07205 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HO397_RS07210 ENOG4108IUE nitrate reductase beta subunit HO397_RS07215 ENOG4105CRU nitrate reductase, alpha subunit HO397_RS07220 ENOG4107QND Nitrite extrusion protein HO397_RS07235 ENOG4105RPH Inner membrane protein YddG HO397_RS07245 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HO397_RS07250 ENOG4108MG3 formate dehydrogenase HO397_RS07255 ENOG41084S7 Plasmid maintenance system antidote protein HO397_RS07260 ENOG4105DQ4 alcohol dehydrogenase HO397_RS07265 ENOG4107R1I NAD-dependent malic enzyme HO397_RS07270 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HO397_RS07275 ENOG4105TPS biofilm-dependent modulation protein HO397_RS07280 ENOG4108Z9K Osmotically inducible protein HO397_RS07285 ENOG4107H6U ABC transporter HO397_RS07290 ENOG4105C3U ABC transporter HO397_RS07295 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HO397_RS07300 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HO397_RS07305 ENOG4105DEF Extracellular solute-binding protein, family 5 HO397_RS07310 ENOG4108UQS dipeptidase HO397_RS07315 ENOG4105BZU Histidine kinase HO397_RS07325 ENOG4105F32 YngK protein HO397_RS07330 ENOG4105E5D amino acid HO397_RS07335 ENOG4105CVK Glutamate decarboxylase HO397_RS07340 ENOG4107RAN Peptidase, M16 HO397_RS07345 ENOG4105PE1 Receptor HO397_RS07350 ENOG4105CQ0 ABC transporter HO397_RS07360 ENOG4105C4X radical SAM domain protein HO397_RS07365 ENOG4105ENH Sulfatase HO397_RS07370 ENOG4105Z68 AraC Family Transcriptional Regulator HO397_RS07380 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HO397_RS07385 ENOG4106PIH fimbrial-like protein ydeQ HO397_RS07390 ENOG4106318 fimbrial-like protein YdeR HO397_RS07395 ENOG4108WDE Fimbrial protein HO397_RS07405 ENOG4105CW0 outer membrane usher protein HO397_RS07410 ENOG4105CW0 outer membrane usher protein HO397_RS07420 ENOG4108RQP Major type 1 subunit fimbrin HO397_RS07425 ENOG4105CAF HipA N-terminal domain protein HO397_RS07430 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HO397_RS07445 ENOG4105D4B ABC, transporter HO397_RS07455 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HO397_RS07460 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HO397_RS07465 ENOG4105FFC UPF0187 protein HO397_RS07475 ENOG4105BZU Histidine kinase HO397_RS07480 ENOG4105M0C cytoplasmic protein HO397_RS07485 ENOG4105CSV Glutaminase HO397_RS07490 ENOG4105C26 Dehydrogenase HO397_RS07495 ENOG4105EGI Transcriptional regulator HO397_RS07525 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HO397_RS07530 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HO397_RS07535 ENOG4106DNR multiple antibiotic resistance protein HO397_RS07540 ENOG4108594 Permease of the drug metabolite transporter HO397_RS07545 ENOG4105E5W Transporter HO397_RS07555 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HO397_RS07560 ENOG4108YDI single-species biofilm formation on inanimate substrate HO397_RS07565 ENOG4108WTK competence damage-inducible protein HO397_RS07570 ENOG4105DGW oligopeptidase A HO397_RS07575 ENOG4105EMU Dehydrogenase HO397_RS07580 ENOG4107XBN GntR Family Transcriptional Regulator HO397_RS07585 ENOG41061EV selenium-binding protein YdfZ HO397_RS07590 ENOG4105DEI Mannitol dehydrogenase HO397_RS07605 ENOG4105W3V DNA-binding, transcriptional regulator HO397_RS07610 ENOG4105MN3 Resolvase HO397_RS07665 ENOG4105HRS Antitermination protein HO397_RS07670 ENOG4108MXB Protein of unknown function (DUF968) HO397_RS07670 ENOG4108MXB Protein of unknown function (DUF968) HO397_RS07685 ENOG4105WI6 cell killing protein encoded within cryptic prophage HO397_RS07715 ENOG41087BU transcriptional repressor DicA HO397_RS07740 ENOG4106G8A Qin prophage HO397_RS07765 ENOG4105CPQ Dehydrogenase HO397_RS07770 ENOG4105CXK mandelate racemase muconate lactonizing HO397_RS07785 ENOG4108MK9 spermidine N(1)-acetyltransferase HO397_RS07790 ENOG4105D69 UPF0257 lipoprotein ynfC HO397_RS07795 ENOG4105KBG Protein of unknown function (DUF1161) HO397_RS07800 ENOG4107QY8 reductase HO397_RS07805 ENOG4105C3J Cysteine desulfurase HO397_RS07810 ENOG4105QAX Iron-sulfur HO397_RS07815 ENOG4107KGK dmso reductase anchor subunit HO397_RS07820 ENOG4108NEM leader-binding protein dmsD HO397_RS07830 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HO397_RS07835 ENOG4105DAG ROK family HO397_RS07840 ENOG4106NZI LysR family Transcriptional regulator HO397_RS07845 ENOG4105D94 Major Facilitator Superfamily HO397_RS07860 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HO397_RS07875 ENOG4105DSF transport protein HO397_RS07880 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HO397_RS07885 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HO397_RS07890 ENOG4105C5D exported protein HO397_RS07895 ENOG4105D5Q Arginine ornithine antiporter HO397_RS07905 ENOG4105RA2 Membrane HO397_RS07910 ENOG4107EXC regulatoR HO397_RS07915 ENOG4105JJR Histidine kinase HO397_RS07925 ENOG4105C9Q fumarate hydratase class II HO397_RS07930 ENOG4107GFK fumarate HO397_RS07935 ENOG4105EIP mannose-6-phosphate isomerase HO397_RS07940 ENOG4106J39 exported protein HO397_RS07945 ENOG4108QNI outer membrane porin protein HO397_RS07950 ENOG4105CT4 transporter HO397_RS07955 ENOG4105CNT hydrolase family 2 HO397_RS07960 ENOG4105XEA Tetr family transcriptional regulator HO397_RS07965 ENOG4107ZQV short-chain dehydrogenase reductase HO397_RS07970 ENOG4107P2S Transcriptional regulator HO397_RS07975 ENOG4105CI1 PTS System HO397_RS07980 ENOG4105C87 Aminotransferase class I and II HO397_RS07990 ENOG4105D9R oxidoreductase HO397_RS07995 ENOG4106C6R beta-lactam resistance protein HO397_RS08000 ENOG4105QZ5 OriC-binding nucleoid-associated protein HO397_RS08005 ENOG4105M9B inner membrane protein ydgK HO397_RS08030 ENOG4108UQQ Electron transport complex HO397_RS08040 ENOG4105CSM endonuclease III HO397_RS08045 ENOG4105DUX Transporter HO397_RS08050 ENOG4108K3A Glutathione S-transferase HO397_RS08055 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HO397_RS08070 ENOG410642K Lysozyme inhibitor HO397_RS08080 ENOG4108XTF Outer Membrane Lipoprotein HO397_RS08095 ENOG4105Y49 secretion protein, HlyD family HO397_RS08100 ENOG4105DSW Fusaric acid resistance protein HO397_RS08105 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HO397_RS08110 ENOG4107RGM aldo keto reductase HO397_RS08115 ENOG4105XZD Fe-S protein HO397_RS08120 ENOG4108WUH Transcriptional regulator, TetR family HO397_RS08125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HO397_RS08130 ENOG4108UYE Lactoylglutathione lyase HO397_RS08140 ENOG4107QRT dEAD DEAH box helicase HO397_RS08145 ENOG4105M2J Glutaredoxin HO397_RS08155 ENOG4105K4H Nlp p60 protein HO397_RS08160 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HO397_RS08165 ENOG4105F27 Major Facilitator HO397_RS08180 ENOG4105F52 Transcriptional regulator HO397_RS08185 ENOG4105CZQ inner membrane transport protein YdhC HO397_RS08190 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HO397_RS08195 ENOG4108R6K riboflavin synthase, subunit alpha HO397_RS08220 ENOG4105N0V mono-oxygenase ydhR HO397_RS08225 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HO397_RS08230 ENOG4108Y7C Conserved Protein HO397_RS08235 ENOG4108NWD Cytochrome HO397_RS08240 ENOG4108393 oxidoreductase Fe-S subunit HO397_RS08245 ENOG4105JVW HO397_RS08250 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HO397_RS08255 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HO397_RS08260 ENOG4105RFR Protein of unknown function (DUF2767) HO397_RS08265 ENOG4105CA9 Pyruvate kinase HO397_RS08270 ENOG4105KMX major outer membrane lipoprotein HO397_RS08275 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HO397_RS08290 ENOG4105JRK feS assembly protein SufD HO397_RS08295 ENOG4105C3K feS assembly ATPase SufC HO397_RS08305 ENOG410671Z uncharacterized protein ydiH HO397_RS08310 ENOG4105KA0 thioesterase Superfamily protein HO397_RS08315 ENOG4105CQB FAD linked oxidase domain protein HO397_RS08320 ENOG4105IPI Membrane HO397_RS08330 ENOG4105SUA Ydil protein HO397_RS08340 ENOG4105EMV Major Facilitator HO397_RS08355 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HO397_RS08360 ENOG4105C1G acyl-Coa dehydrogenase HO397_RS08365 ENOG4105W4W Transcriptional regulator HO397_RS08370 ENOG4105CV7 Electron transfer flavoprotein HO397_RS08375 ENOG4105C10 Electron transfer flavoprotein HO397_RS08380 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HO397_RS08385 ENOG41090P5 ferredoxin-like protein HO397_RS08390 ENOG4105CEY Amp-dependent synthetase and ligase HO397_RS08395 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HO397_RS08405 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HO397_RS08425 ENOG4108QBX (LipO)protein HO397_RS08435 ENOG4108V06 Glutathione peroxidase HO397_RS08450 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HO397_RS08470 ENOG41082NX 50s ribosomal protein l35 HO397_RS08475 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HO397_RS08495 ENOG4108NE3 Salt-induced outer membrane protein HO397_RS08500 ENOG4105DE4 1-phosphofructokinase HO397_RS08505 ENOG4105P10 Uncharacterized protein ydiZ HO397_RS08515 ENOG4107PN8 YfeABCD locus regulator HO397_RS08520 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HO397_RS08525 ENOG4107K5X Membrane-bound metal-dependent hydrolase HO397_RS08530 ENOG4108ETY sodium dicarboxylate symporter HO397_RS08545 ENOG4105CH6 catalase HO397_RS08550 ENOG410901P UPF0249 protein HO397_RS08555 ENOG4105F8D glycoside hydrolase family 4 HO397_RS08560 ENOG4105EZV Transcriptional regulator HO397_RS08565 ENOG4105VCP PTS System HO397_RS08570 ENOG4105CK1 PTS System HO397_RS08575 ENOG4105VZJ PTS System HO397_RS08580 ENOG4105KKI DNA-binding transcriptional activator OsmE HO397_RS08590 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HO397_RS08600 ENOG4108SPG Periplasmic Protein HO397_RS08610 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HO397_RS08630 ENOG4105CGK Exodeoxyribonuclease III HO397_RS08635 ENOG4108RSN SNARE associated Golgi HO397_RS08640 ENOG4108KCW iron-sulfur cluster binding HO397_RS08645 ENOG4108N5C SNARE associated Golgi protein-related protein HO397_RS08650 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HO397_RS08655 ENOG4105VNH ABC transporter solute-binding protein HO397_RS08660 ENOG4105CXZ ABC transporter, permease HO397_RS08665 ENOG4108VGW abc transporter atp-binding protein HO397_RS08670 ENOG4107RM6 sulfurtransferase HO397_RS08675 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HO397_RS08680 ENOG4105M6F mutator MutT protein HO397_RS08685 ENOG4105MTM Protein of unknown function (DUF1496) HO397_RS08690 ENOG4105D82 Glutamate dehydrogenase HO397_RS08695 ENOG41065FB inner membrane protein ynji HO397_RS08700 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HO397_RS08710 ENOG41069NU Nitroreductase HO397_RS08715 ENOG4105D07 Signal peptide peptidase, SppA HO397_RS08720 ENOG4105HDK L-asparaginase HO397_RS08725 ENOG4108RWI nicotinamidase HO397_RS08730 ENOG4108KUU Inner membrane metabolite transport protein ydjE HO397_RS08735 ENOG4105E98 transcriptional regulator DeoR family HO397_RS08740 ENOG4105CPC Aldo Keto reductase HO397_RS08745 ENOG4107UH8 sugar kinase HO397_RS08750 ENOG4105D2N Aldolase HO397_RS08755 ENOG4105CPQ Dehydrogenase HO397_RS08760 ENOG4107TE1 transport protein HO397_RS08765 ENOG4105CPQ Dehydrogenase HO397_RS08770 ENOG4105VUT cytoplasmic protein HO397_RS08780 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HO397_RS08785 ENOG4105DSB aldose 1-epimerase HO397_RS08790 ENOG4105CV8 reductase HO397_RS08795 ENOG4105GNX MltA-interacting MipA family protein HO397_RS08810 ENOG4106KTS Inner membrane protein yeaI HO397_RS08815 ENOG4108KHP Diguanylate cyclase HO397_RS08820 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HO397_RS08835 ENOG4105R1U AraC Family Transcriptional Regulator HO397_RS08840 ENOG4105DJ2 Major Facilitator Superfamily HO397_RS08845 ENOG4105K78 MarR family Transcriptional regulator HO397_RS08850 ENOG4105UCG Domain of unknown function (DUF333) HO397_RS08855 ENOG410620I Diguanylate cyclase HO397_RS08860 ENOG4106G4W HO397_RS08870 ENOG4105Y3U Transglycosylase-associated protein HO397_RS08875 ENOG4105YP6 Domain of unknown function (DUF1869) HO397_RS08885 ENOG4108SER Transposase HO397_RS08890 ENOG4108YS1 cytoplasmic protein HO397_RS08900 ENOG4105EJC lysr family transcriptional regulator HO397_RS08905 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HO397_RS08915 ENOG4105DVW rieske (2Fe-2S) HO397_RS08920 ENOG4105E3J oxidoreductase HO397_RS08925 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HO397_RS08930 ENOG4105CEY Amp-dependent synthetase and ligase HO397_RS08935 ENOG4105Y4Z Outer Membrane Lipoprotein HO397_RS08940 ENOG41072GX Peptidase M22 Glycoprotease HO397_RS08945 ENOG4105DVT helicase HO397_RS08950 ENOG4105M4H endoribonuclease L-psp HO397_RS08955 ENOG4105V2F Uncharacterized protein yoac HO397_RS08965 ENOG4105CRQ synthase (Component I) HO397_RS08975 ENOG4105EJQ L-serine dehydratase HO397_RS08980 ENOG4107XTP (EAL) domain protein HO397_RS08985 ENOG4105EE5 Membrane protein terC HO397_RS08990 ENOG4105DAS pts system HO397_RS08995 ENOG4105ETZ PTS System HO397_RS09000 ENOG4105F3R pts system mannose fructose sorbose family iid HO397_RS09015 ENOG4105DHI Methyltransferase HO397_RS09030 ENOG4105Q3Y exported protein HO397_RS09040 ENOG4105TIK HO397_RS09045 ENOG4105J4Q Transcriptional regulator HO397_RS09050 ENOG4105C0R drug resistance transporter emrb qaca subfamily HO397_RS09060 ENOG4105CN1 protease HO397_RS09070 ENOG4108ZGC gaf domain protein HO397_RS09075 ENOG4105H2K paraquat-inducible protein a HO397_RS09080 ENOG4105DY2 Paraquat-inducible protein b HO397_RS09090 ENOG4105WT8 Protein of unknown function (DUF1480) HO397_RS09095 ENOG4105UVW uncharacterized protein yebW HO397_RS09100 ENOG4108R1E Serine threonine protein phosphatase 1 HO397_RS09105 ENOG4105NKT exported protein HO397_RS09110 ENOG4108PNC copper resistance HO397_RS09115 ENOG4105FXM Copper resistance protein HO397_RS09120 ENOG4105MPK DNA polymerase III subunit theta HO397_RS09125 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HO397_RS09130 ENOG4105UMD exodeoxyribonuclease X HO397_RS09135 ENOG4105CUG Oligopeptidase b HO397_RS09140 ENOG4108Q2J Inner membrane protein YebE HO397_RS09150 ENOG4105X2V dna damage-inducible protein HO397_RS09160 ENOG4108UHU Aldolase HO397_RS09165 ENOG4105C01 Dihydroxy-acid dehydratase HO397_RS09170 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HO397_RS09175 ENOG4106KNT transcriptional regulator HO397_RS09180 ENOG4105CA9 Pyruvate kinase HO397_RS09185 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HO397_RS09190 ENOG4105DR5 peptidase HO397_RS09195 ENOG4105NXV High-affinity zinc uptake system protein HO397_RS09205 ENOG4105FAV ABC, transporter HO397_RS09225 ENOG4107S01 Repressor protein MetJ HO397_RS09235 ENOG4105CDY transcriptional regulatory protein HO397_RS09240 ENOG4108TIT dATP pyrophosphohydrolase HO397_RS09250 ENOG4105D3W isochorismatase HO397_RS09255 ENOG41081XQ Conserved Protein HO397_RS09260 ENOG4105WJG Glutathione HO397_RS09275 ENOG4107QY8 reductase HO397_RS09280 ENOG4105CUW cytochrome C-TYPE protein HO397_RS09290 ENOG4106ZCM YecM protein HO397_RS09295 ENOG4105C75 arginyL-tRNA synthetase HO397_RS09305 ENOG4105W13 flagellar protein HO397_RS09310 ENOG4105D7B Flagellar biosynthesis protein flha HO397_RS09315 ENOG4105D00 flagellar biosynthetic protein flhB HO397_RS09320 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HO397_RS09325 ENOG4108VYJ response regulator receiver protein HO397_RS09335 ENOG4105BZU Histidine kinase HO397_RS09340 ENOG4105C8Q Methyl-accepting chemotaxis HO397_RS09345 ENOG4105C8Q Methyl-accepting chemotaxis HO397_RS09350 ENOG4108V3W Chemotaxis protein, CheW HO397_RS09355 ENOG4105CBS Chea signal transduction histidine kinase HO397_RS09360 ENOG4105ER2 Ompa motb domain protein HO397_RS09365 ENOG4107RD7 Flagellar Motor Protein, MotA HO397_RS09370 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HO397_RS09380 ENOG4108VA4 Universal stress protein HO397_RS09390 ENOG4108K4C ec 3.1.3.12 HO397_RS09395 ENOG4105CNN ABC, transporter HO397_RS09400 ENOG4105C2J ABC transporter HO397_RS09405 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HO397_RS09410 ENOG4108UEC Ferritin-like protein HO397_RS09415 ENOG4105N4N Protein of unknown function (DUF2766) HO397_RS09425 ENOG4105P23 (LipO)protein HO397_RS09430 ENOG41090A1 ferritin HO397_RS09435 ENOG4105VVZ metal-binding protein HO397_RS09440 ENOG4105E0U tyrosine-specific transport protein HO397_RS09445 ENOG4106RHG Yeca family HO397_RS09470 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HO397_RS09490 ENOG4107ZY3 Histidine kinase HO397_RS09495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HO397_RS09500 ENOG4105VT2 5-hydroxyisourate hydrolase HO397_RS09505 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HO397_RS09515 ENOG4108MEK Metal-binding protein YodA HO397_RS09520 ENOG4108VKM cytochrome b561 HO397_RS09540 ENOG4105TNG K13735 adhesin invasin HO397_RS09550 ENOG4105CSH Transporter HO397_RS09555 ENOG4105FYV Amp nucleosidase HO397_RS09560 ENOG4105CDY transcriptional regulatory protein HO397_RS09570 ENOG4105UQX Mate efflux family protein HO397_RS09580 ENOG4107R11 Transcriptional regulator HO397_RS09585 ENOG4106P55 Transcriptional regulator HO397_RS09595 ENOG4108PXI ErfK YbiS YcfS YnhG HO397_RS09600 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HO397_RS09605 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HO397_RS09610 ENOG4108YZT Adenosylcobinamide kinase HO397_RS09660 ENOG4105DR8 Membrane HO397_RS09670 ENOG4105DZ1 carboxypeptidase HO397_RS09675 ENOG4105CJB Exodeoxyribonuclease I HO397_RS09685 ENOG4105CUC YeeE YedE family protein HO397_RS09690 ENOG4105CUB amino acid HO397_RS09700 ENOG4105EQ1 Transcriptional regulator HO397_RS09705 ENOG4107SRH Nad-dependent epimerase dehydratase HO397_RS09720 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HO397_RS09730 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HO397_RS09735 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HO397_RS09750 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HO397_RS09755 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HO397_RS09760 ENOG4105C6Y Udp-glucose 6-dehydrogenase HO397_RS09765 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HO397_RS09770 ENOG4107QKV phosphomannomutase HO397_RS09775 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HO397_RS09785 ENOG4108RYC glycosyltransferase HO397_RS09810 ENOG4108UT6 Transferase hexapeptide repeat containing protein HO397_RS09825 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HO397_RS09830 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HO397_RS09835 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HO397_RS09840 ENOG4105C1B dTDP-glucose 4-6-dehydratase HO397_RS09845 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HO397_RS09850 ENOG4105G1A colanic acid biosynthesis protein HO397_RS09855 ENOG4107T8Q Glycosyl transferase (Group 1 HO397_RS09860 ENOG4105C74 pyruvyl transferase HO397_RS09865 ENOG4105PSV Polysaccharide Biosynthesis Protein HO397_RS09870 ENOG4105D3Q Sugar transferase HO397_RS09875 ENOG4107QKV phosphomannomutase HO397_RS09880 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HO397_RS09885 ENOG4106CD9 glycosyl transferase group 1 HO397_RS09890 ENOG4105FGF GDP-mannose mannosyl hydrolase HO397_RS09895 ENOG4105C30 Nad-dependent epimerase dehydratase HO397_RS09900 ENOG4105C0K Gdp-mannose 4,6-dehydratase HO397_RS09905 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HO397_RS09910 ENOG4105ECJ Glycosyl Transferase HO397_RS09915 ENOG4108NYJ Colanic acid HO397_RS09920 ENOG4107RXY Glycosyl transferase HO397_RS09925 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HO397_RS09930 ENOG41090RK glycosyl transferase HO397_RS09935 ENOG4105D75 Capsular exopolysaccharide family HO397_RS09940 ENOG4105KJF protein tyrosine phosphatase HO397_RS09945 ENOG4105DAY polysaccharide export protein HO397_RS09950 ENOG4105EE5 Membrane protein terC HO397_RS09955 ENOG4108GAE asmA family HO397_RS09965 ENOG4105DBI uridine monophosphokinase HO397_RS09970 ENOG4105BZU Histidine kinase HO397_RS09975 ENOG4105D03 DNA-3-methyladenine glycosylase II HO397_RS09980 ENOG4105R8A Heat shock protein HO397_RS09985 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HO397_RS09990 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HO397_RS09995 ENOG4108M24 von Willebrand factor, type A HO397_RS10030 ENOG4105BZS acriflavin resistance protein HO397_RS10040 ENOG4105EB3 Histidine kinase HO397_RS10045 ENOG4105E3W Two component transcriptional regulator (Winged helix family HO397_RS10050 ENOG4105KWI UPF0339 protein HO397_RS10055 ENOG4105CFP Peptidase U32 HO397_RS10060 ENOG41076Z6 Uncharacterized protein yegR HO397_RS10085 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HO397_RS10090 ENOG4105DT3 PTS system, galactitol-specific IIc component HO397_RS10095 ENOG41090UW PTS System HO397_RS10100 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HO397_RS10115 ENOG4105EIE fructose-bisphosphate aldolase HO397_RS10120 ENOG4105EAA nucleoside HO397_RS10125 ENOG4108KD5 ADP-ribosylation crystallin J1 HO397_RS10130 ENOG4108TFM Kinase, PfkB family HO397_RS10135 ENOG4105FDP GntR family transcriptional regulator HO397_RS10140 ENOG4108UQ1 hydrolase, family 25 HO397_RS10145 ENOG4105DWF phosphomethylpyrimidine kinase HO397_RS10195 ENOG4105D1F ATP-binding protein HO397_RS10205 ENOG4108KDT Molybdate metabolism regulator HO397_RS10210 ENOG4108KDT Molybdate metabolism regulator HO397_RS10220 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HO397_RS10225 ENOG4105RD5 HO397_RS10230 ENOG4105DEG Vwa containing coxe family protein HO397_RS10235 ENOG410903U zinc ion binding HO397_RS10240 ENOG4108YCW (LipO)protein HO397_RS10245 ENOG4108W15 Protein of unknown function (DUF1456) HO397_RS10250 ENOG4108NEV two component transcriptional regulator, LytTR family HO397_RS10255 ENOG4108HRK Histidine kinase HO397_RS10260 ENOG4108XDN Transcriptional regulator HO397_RS10270 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HO397_RS10275 ENOG4108IJ8 ABC transporter HO397_RS10280 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HO397_RS10285 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HO397_RS10290 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HO397_RS10295 ENOG4105CXG d-lactate dehydrogenase HO397_RS10300 ENOG41061WM D-Alanyl-D-Alanine HO397_RS10305 ENOG41069YE inner membrane protein yohC HO397_RS10310 ENOG4105KHU inner membrane protein YohD HO397_RS10315 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HO397_RS10320 ENOG4105ETP RND efflux system, outer membrane lipoprotein HO397_RS10330 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HO397_RS10340 ENOG41067MG lrgb family HO397_RS10350 ENOG4107GZ4 SanA protein HO397_RS10355 ENOG4105Y9N Membrane HO397_RS10360 ENOG4105BZ8 glutamate synthase HO397_RS10365 ENOG4107SJI Dehydrogenase HO397_RS10370 ENOG4108HWV )-transporter HO397_RS10375 ENOG4105C2J ABC transporter HO397_RS10385 ENOG41060NJ transcriptional regulator HO397_RS10390 ENOG4105DHF Membrane HO397_RS10405 ENOG4105D05 Receptor HO397_RS10410 ENOG4108IQI permease HO397_RS10415 ENOG4105DUM transcriptional regulator, lysR family HO397_RS10420 ENOG4105HMI Membrane HO397_RS10430 ENOG4105DD7 kinase (PfkB family HO397_RS10435 ENOG4105D9N nucleoside HO397_RS10445 ENOG4108Y4K DNA-binding transcriptional activator HO397_RS10450 ENOG4105D9N nucleoside HO397_RS10455 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HO397_RS10460 ENOG4105DD7 kinase (PfkB family HO397_RS10465 ENOG4105DM4 PTS System HO397_RS10470 ENOG4105DE4 1-phosphofructokinase HO397_RS10475 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HO397_RS10480 ENOG4105S8Q sugar efflux transporter HO397_RS10485 ENOG4105KRS Proteinase inhibitor HO397_RS10495 ENOG4105DEI Mannitol dehydrogenase HO397_RS10500 ENOG4105CKI cobalamin synthesis protein HO397_RS10505 ENOG41076MN Phosphoesterase, PA-phosphatase related HO397_RS10510 ENOG4107TT5 NLP P60 protein HO397_RS10515 ENOG4105CXC rtn protein HO397_RS10520 ENOG4105E43 Extracellular solute-binding protein, family 5 HO397_RS10525 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HO397_RS10530 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HO397_RS10535 ENOG4108JQ5 ABC transporter HO397_RS10540 ENOG4105HG6 HO397_RS10545 ENOG4105C2C drug resistance transporter, Bcr CflA HO397_RS10550 ENOG4105I08 Pseudouridine synthase HO397_RS10555 ENOG4105CFI type iii restriction protein res subunit HO397_RS10575 ENOG4105E68 Sulfatase HO397_RS10585 ENOG4108MGN ATP-binding component of a transport system HO397_RS10590 ENOG4105WH1 Two component transcriptional regulator luxr family HO397_RS10595 ENOG4105KWW Biogenesis protein HO397_RS10600 ENOG4107QX9 Thiol disulfide interChange protein HO397_RS10605 ENOG4105DA4 cytochrome c-type biogenesis protein HO397_RS10615 ENOG4105X3C heme exporter protein HO397_RS10620 ENOG41060IM Heme exporter protein HO397_RS10625 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HO397_RS10630 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HO397_RS10635 ENOG4105CUW cytochrome C-TYPE protein HO397_RS10640 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HO397_RS10645 ENOG4105GXZ Ferredoxin-type protein NapH HO397_RS10650 ENOG4108BGM Quinol dehydrogenase periplasmic component HO397_RS10660 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HO397_RS10665 ENOG4108ZNS ferredoxin-type protein NapF HO397_RS10675 ENOG4105DWT malate dehydrogenase (quinone) HO397_RS10680 ENOG4105IBP Cyclic peptide transporter HO397_RS10685 ENOG4105CF1 Alkylated DNA repair protein HO397_RS10690 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HO397_RS10695 ENOG4105CJ2 (LipO)protein HO397_RS10700 ENOG4105FCK Membrane HO397_RS10710 ENOG4105BZU Histidine kinase HO397_RS10715 ENOG4105BZU Histidine kinase HO397_RS10720 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HO397_RS10725 ENOG4107QP7 CoA-transferase subunit A HO397_RS10730 ENOG4107QNJ CoA-transferase subunit B HO397_RS10735 ENOG4105CRW Short chain fatty acid transporter HO397_RS10740 ENOG4105CHU acetyl-coa acetyltransferase HO397_RS10745 ENOG4105EDV vault protein HO397_RS10750 ENOG41081SK signal peptide protein HO397_RS10755 ENOG4107S52 alpha-2-macroglobulin domain protein HO397_RS10760 ENOG4108QJJ Protein of unknown function (DUF1175) HO397_RS10765 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HO397_RS10770 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HO397_RS10775 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HO397_RS10780 ENOG4107GHC outer membrane autotransporter HO397_RS10785 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HO397_RS10790 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HO397_RS10795 ENOG4105XPH Ferredoxin HO397_RS10800 ENOG4105FQR PH-inducible protein involved in stress response HO397_RS10810 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HO397_RS10815 ENOG4105CXY transporter HO397_RS10820 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HO397_RS10830 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HO397_RS10835 ENOG4105DNE Transposase HO397_RS10845 ENOG4105CSP Major Facilitator Superfamily HO397_RS10850 ENOG4105CXK mandelate racemase muconate lactonizing HO397_RS10855 ENOG4107258 Transcriptional regulator HO397_RS10860 ENOG4108EWA cinA-like protein HO397_RS10865 ENOG4108UII YfaZ family HO397_RS10870 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HO397_RS10875 ENOG4108WMR Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity) HO397_RS10890 ENOG4105C3I Nad-dependent epimerase dehydratase HO397_RS10900 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HO397_RS10910 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HO397_RS10915 ENOG4106GZG polymyxin resistance protein B HO397_RS10920 ENOG4105CEY Amp-dependent synthetase and ligase HO397_RS10925 ENOG4105DNI Converts SHCHC to OSB (By similarity) HO397_RS10930 ENOG4108IPT Naphthoate synthase HO397_RS10935 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HO397_RS10945 ENOG4105E4F Isochorismate synthase HO397_RS10950 ENOG4105TNS Conserved Protein HO397_RS10955 ENOG4107YB6 acetyltransferase, (GNAT) family HO397_RS10965 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is HO397_RS10975 ENOG4105GDX Domain of unknown function (DUF1877) HO397_RS10990 ENOG4105C8S subunit m HO397_RS10995 ENOG4105D65 subunit l HO397_RS11005 ENOG4107UFS subunit j HO397_RS11020 ENOG4108IEH NADH dehydrogenase subunit g HO397_RS11025 ENOG4107QIZ NADH dehydrogenase HO397_RS11030 ENOG4105GKE subunit e HO397_RS11050 ENOG4107NQ8 LysR family Transcriptional regulator HO397_RS11055 ENOG4105CHM Aminotransferase HO397_RS11065 ENOG4107QWE )-transporter HO397_RS11070 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HO397_RS11075 ENOG4105XWI UPF0304 protein HO397_RS11085 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HO397_RS11090 ENOG4105C6K Malic enzyme HO397_RS11095 ENOG4105CSX c4-dicarboxylate anaerobic carrier HO397_RS11100 ENOG4105PTV Nudix Hydrolase HO397_RS11105 ENOG4108RE9 Phosphodiesterase HO397_RS11110 ENOG4108SHQ Glutathione S-transferase HO397_RS11115 ENOG4105CYM Glutathione S-transferase HO397_RS11120 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HO397_RS11125 ENOG4105ECP epimerase HO397_RS11130 ENOG4105DNE Transposase HO397_RS11135 ENOG4108JEH abc transporter atp-binding protein HO397_RS11140 ENOG4106YG3 ABC transporter HO397_RS11145 ENOG4105DSP amino acid AbC transporter HO397_RS11150 ENOG4105E89 ABC transporter HO397_RS11155 ENOG4105E89 ABC transporter HO397_RS11160 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HO397_RS11165 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HO397_RS11170 ENOG4105E96 Colicin v production protein HO397_RS11175 ENOG4108S3P Sporulation domain protein HO397_RS11180 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HO397_RS11190 ENOG4105DQR SNARE associated Golgi HO397_RS11200 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HO397_RS11205 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HO397_RS11210 ENOG4106WZ1 flagella biosynthesis regulator HO397_RS11215 ENOG4105F9N Major Facilitator Superfamily HO397_RS11220 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HO397_RS11225 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HO397_RS11230 ENOG4105MH2 YfcL protein HO397_RS11235 ENOG4108BPE -transporting atpase HO397_RS11240 ENOG4105EJ9 Membrane HO397_RS11245 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HO397_RS11250 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HO397_RS11270 ENOG4105US4 fimbrial-like protein yfcP HO397_RS11275 ENOG4105UGQ Fimbrial HO397_RS11280 ENOG4105NEV Fimbrial HO397_RS11285 ENOG4108FZ9 Chaperone HO397_RS11290 ENOG4106PG1 outer membrane usher protein HO397_RS11300 ENOG4108BY2 phosphohistidine phosphatase HO397_RS11305 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HO397_RS11310 ENOG4105CHU acetyl-coa acetyltransferase HO397_RS11315 ENOG4105KZW UPF0381 protein HO397_RS11320 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HO397_RS11340 ENOG410903C (LipO)protein HO397_RS11345 ENOG4105S64 Formate nitrite transporter HO397_RS11355 ENOG4105W8I Transcriptional regulator HO397_RS11360 ENOG4105C6Z Gluconate HO397_RS11370 ENOG4105C0R drug resistance transporter emrb qaca subfamily HO397_RS11375 ENOG4105CW7 secretion protein, HlyD family HO397_RS11380 ENOG4108WQH regulatoR HO397_RS11385 ENOG4105BZU Histidine kinase HO397_RS11390 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HO397_RS11395 ENOG4108N2Y auxin Efflux HO397_RS11400 ENOG4105CFN oxalyl-CoA decarboxylase HO397_RS11410 ENOG4108V08 YfdX protein HO397_RS11420 ENOG4105W9M Membrane HO397_RS11425 ENOG4105D1S lipid A biosynthesis HO397_RS11435 ENOG4105CHM Aminotransferase HO397_RS11440 ENOG4108HRK Histidine kinase HO397_RS11445 ENOG4105DY9 regulatoR HO397_RS11450 ENOG4108CIP transcriptional regulator HO397_RS11455 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HO397_RS11460 ENOG4105CN9 Peptidase m42 family protein HO397_RS11465 ENOG4105DC7 peptidase M24 HO397_RS11470 ENOG410863U PTS System HO397_RS11475 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HO397_RS11485 ENOG4105VCT ion-transport protein YfeO HO397_RS11490 ENOG4109076 Conserved Protein HO397_RS11500 ENOG4105D9N nucleoside HO397_RS11505 ENOG4108KMM Diguanylate cyclase HO397_RS11520 ENOG4105HZG regulatoR HO397_RS11525 ENOG4105GXM Putative transcription regulator (DUF1323) HO397_RS11560 ENOG4108M0I Transcriptional regulator HO397_RS11565 ENOG4105DHU Bile acid HO397_RS11570 ENOG4105VRT cytoplasmic protein HO397_RS11590 ENOG4105C6T cysteine synthase HO397_RS11600 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HO397_RS11605 ENOG4105C5Y PTS System HO397_RS11615 ENOG4105M0Y HO397_RS11620 ENOG4105WEC Molybdate metabolism regulator HO397_RS11625 ENOG4105C6T cysteine synthase HO397_RS11630 ENOG4108IJ6 ABC transporter HO397_RS11635 ENOG4105ECW sulfate abc transporter HO397_RS11640 ENOG4108I5D sulfate abc transporter HO397_RS11645 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HO397_RS11650 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HO397_RS11655 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) HO397_RS11665 ENOG4105C5Y PTS System HO397_RS11670 ENOG4105EZR dyp-type peroxidase family protein HO397_RS11675 ENOG4105E7K (LipO)protein HO397_RS11680 ENOG4105QZU Inner membrane protein YfeZ HO397_RS11690 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HO397_RS11700 ENOG4108K3Z AraC family transcriptional regulator HO397_RS11705 ENOG4108X49 Ethanolamine utilization protein EutK HO397_RS11710 ENOG4106D67 ethanolamine utilization protein HO397_RS11720 ENOG4105CPD ethanolamine ammonia-lyase HO397_RS11725 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HO397_RS11730 ENOG4105ENY Ethanolamine utilization protein eutH HO397_RS11735 ENOG4105C0A alcohol dehydrogenase HO397_RS11740 ENOG4107RWI ethanolamine utilization protein eutJ HO397_RS11745 ENOG4108EKI Dehydrogenase HO397_RS11750 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HO397_RS11755 ENOG4105KNY Microcompartments protein HO397_RS11760 ENOG4107WUY phosphate acetyltransferase HO397_RS11765 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HO397_RS11770 ENOG4105NDK ethanolamine utilization protein HO397_RS11775 ENOG4106S4J ethanolamine utilization protein EutP HO397_RS11780 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HO397_RS11785 ENOG4105C6K Malic enzyme HO397_RS11790 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HO397_RS11795 ENOG4105CV1 Transketolase (EC 2.2.1.1) HO397_RS11800 ENOG4108PVD exported protein HO397_RS11810 ENOG4105BZ8 glutamate synthase HO397_RS11815 ENOG4105BZU Histidine kinase HO397_RS11820 ENOG4105BZS acriflavin resistance protein HO397_RS11830 ENOG4105KUZ arsenate reductase HO397_RS11845 ENOG4106KED esterase YpfH HO397_RS11850 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HO397_RS11855 ENOG4105CGZ zinc metallopeptidase HO397_RS11865 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HO397_RS11875 ENOG4105RH4 Glycine cleavage system transcriptional repressor HO397_RS11880 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HO397_RS11885 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HO397_RS11890 ENOG4108JPZ Monovalent cation H antiporter subunit D HO397_RS11910 ENOG4107WQX hydrogenase 4 membrane subunit HO397_RS11915 ENOG4108JPZ Monovalent cation H antiporter subunit D HO397_RS11920 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HO397_RS11930 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HO397_RS11935 ENOG4105I6X formate hydrogenlyase maturation HO397_RS11940 ENOG4108JUA Transcriptional regulator HO397_RS11945 ENOG4105TMB Formate nitrite transporter HO397_RS11950 ENOG4105C02 permease HO397_RS11955 ENOG4105ERG peptidase m48, ste24p HO397_RS11960 ENOG4105K89 arsenate reductase HO397_RS11965 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HO397_RS11970 ENOG4105C2W permease HO397_RS11985 ENOG4108V3E phosphoribosylglycinamide formyltransferase HO397_RS11990 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HO397_RS11995 ENOG4105C9X ppx gppa phosphatase HO397_RS12000 ENOG4105BZU Histidine kinase HO397_RS12010 ENOG41062G3 Protein of unknown function (DUF2633) HO397_RS12015 ENOG4108ZMA Outer membrane lipoprotein HO397_RS12020 ENOG41066DY Membrane HO397_RS12025 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HO397_RS12030 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HO397_RS12035 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HO397_RS12040 ENOG4105VPD cellular component movement HO397_RS12055 ENOG4105N21 Membrane HO397_RS12085 ENOG4108JQB penicillin-binding protein 1C HO397_RS12090 ENOG4105DN3 alpha-2-macroglobulin domain protein HO397_RS12095 ENOG4105KHC sulfurtransferase HO397_RS12105 ENOG4105YYA enhanced serine sensitivity protein SseB HO397_RS12115 ENOG4105WVQ Fe-S assembly protein IscX HO397_RS12120 ENOG4108ZIT Ferredoxin, 2FE-2S HO397_RS12140 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HO397_RS12160 ENOG4105ECY inositol monophosphatase HO397_RS12165 ENOG4107XM9 (LipO)protein HO397_RS12170 ENOG4108MN2 Stationary phase inducible protein CsiE HO397_RS12175 ENOG4105D8G Major Facilitator superfamily HO397_RS12180 ENOG4108W5M transcriptional regulator HO397_RS12185 ENOG4105FUY alpha subunit HO397_RS12210 ENOG4108SB3 DoxX Family HO397_RS12215 ENOG4108ZKT aldose 1-epimerase HO397_RS12220 ENOG4105CPQ Dehydrogenase HO397_RS12225 ENOG4105CNN ABC, transporter HO397_RS12230 ENOG4108F37 ATP-binding component of a transport system HO397_RS12235 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HO397_RS12240 ENOG4107HQ7 repeat protein HO397_RS12245 ENOG4108NZE NAGC-like transcriptional regulator HO397_RS12255 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HO397_RS12265 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HO397_RS12270 ENOG4108SKK alpha helix protein HO397_RS12275 ENOG4107WP9 Histidine kinase HO397_RS12295 ENOG4108Z6B deaminase HO397_RS12300 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HO397_RS12305 ENOG4106G6Q Transcriptional regulator HO397_RS12310 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HO397_RS12325 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HO397_RS12345 ENOG4105C3F Signal peptidase i HO397_RS12355 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HO397_RS12360 ENOG4105VQK sigma E regulatory protein, MucB RseB HO397_RS12365 ENOG41069PW sigma-e factor negative regulatory protein HO397_RS12370 ENOG4105EMN RNA polymerase sigma factor HO397_RS12380 ENOG4108IYU L-aspartate oxidase HO397_RS12390 ENOG4105C1J atp-dependent rna helicase HO397_RS12395 ENOG41090KR LysR family transcriptional Regulator HO397_RS12415 ENOG4105EIB trna rrna methyltransferase HO397_RS12420 ENOG4105K63 Thioredoxin HO397_RS12425 ENOG4106IUH DTW domain containing protein HO397_RS12430 ENOG4105CD5 CoA-binding domain protein HO397_RS12435 ENOG4105JIM Phosphatidylserine synthase HO397_RS12440 ENOG4105T42 (LipO)protein HO397_RS12445 ENOG4105CSH Transporter HO397_RS12470 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HO397_RS12475 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HO397_RS12480 ENOG4105C34 Pseudouridine synthase HO397_RS12485 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HO397_RS12490 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HO397_RS12500 ENOG4105CQC Prephenate dehydratase HO397_RS12505 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HO397_RS12510 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HO397_RS12515 ENOG4105QP9 Protein of unknown function (DUF2799) HO397_RS12520 ENOG4108WS1 HO397_RS12525 ENOG4108KHX Diguanylate cyclase HO397_RS12530 ENOG41090EK ompa motb domain protein HO397_RS12555 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HO397_RS12560 ENOG4106KVJ cytochrome C assembly protein HO397_RS12565 ENOG4108JU6 CBS domain protein HO397_RS12580 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HO397_RS12585 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HO397_RS12595 ENOG4108Z1B Cyclase dehydrase HO397_RS12610 ENOG4105DFP Integrase HO397_RS12620 ENOG4105FA0 parb-like partition protein HO397_RS12640 ENOG4105D5U fad dependent oxidoreductase HO397_RS12645 ENOG4105C26 Dehydrogenase HO397_RS12650 ENOG4108JPW Aminotransferase HO397_RS12655 ENOG4105C85 amino acid HO397_RS12660 ENOG4108PVQ transcriptional regulator HO397_RS12665 ENOG4109066 lysm domain bon superfamily protein HO397_RS12670 ENOG4105VPI YqaE family transport protein HO397_RS12675 ENOG41080HT Transcriptional regulator, arsr family HO397_RS12680 ENOG4108V62 Rhodanese domain protein HO397_RS12685 ENOG4108X73 DNA- binding protein HO397_RS12690 ENOG4108RNS Exports L-alanine (By similarity) HO397_RS12695 ENOG4108WMJ Protein of unknown function (DUF2002) HO397_RS12700 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HO397_RS12705 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HO397_RS12715 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HO397_RS12720 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HO397_RS12725 ENOG4108IJ7 Glycine betaine HO397_RS12730 ENOG4108HQS Glycine betaine HO397_RS12735 ENOG4105GIJ Glycine betaine HO397_RS12745 ENOG4108UMN azlc family HO397_RS12750 ENOG4105ZED uncharacterized protein ygaH HO397_RS12755 ENOG4105NTK Transcriptional repressor Mpra HO397_RS12760 ENOG4105CW7 secretion protein, HlyD family HO397_RS12765 ENOG4105C0R drug resistance transporter emrb qaca subfamily HO397_RS12780 ENOG4105W39 Membrane HO397_RS12785 ENOG4107VXZ Hydrolase HO397_RS12815 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HO397_RS12820 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HO397_RS12835 ENOG4107TH8 cina domain protein HO397_RS12840 ENOG4105CVE Lytic murein transglycosylase HO397_RS12845 ENOG410787A Pts system, glucitol sorbitol-specific HO397_RS12850 ENOG4105DZY Pts system, glucitol sorbitol-specific HO397_RS12855 ENOG4105VI0 Pts system, glucitol sorbitol-specific HO397_RS12860 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HO397_RS12865 ENOG4105J92 DNA-binding transcriptional activator GutM HO397_RS12870 ENOG410804X Transcriptional regulator HO397_RS12875 ENOG4105C2X Arabinose 5-phosphate isomerase HO397_RS12880 ENOG4108JUA Transcriptional regulator HO397_RS12895 ENOG4105C8H hydrogenase maturation protein Hypf HO397_RS12900 ENOG4108RC0 Electron transport protein HO397_RS12905 ENOG4105DDV Transcriptional regulator (LacI family HO397_RS12910 ENOG4105C5Y PTS System HO397_RS12915 ENOG4105CS2 ec 3.2.1.21 HO397_RS12920 ENOG4108MG9 hydrogenase 3 maturation protease HO397_RS12925 ENOG4105I6X formate hydrogenlyase maturation HO397_RS12930 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HO397_RS12935 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HO397_RS12940 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HO397_RS12945 ENOG4107TDF Formate hydrogenlyase subunit 4 HO397_RS12950 ENOG4107R30 NADH dehydrogenase HO397_RS12955 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HO397_RS12960 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HO397_RS12965 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HO397_RS12970 ENOG4107RSS Hydrogenase accessory protein HypB HO397_RS12975 ENOG41083WG hydrogenase assembly chaperone HO397_RS12980 ENOG4105CQS hydrogenase expression formation protein HypD HO397_RS12985 ENOG4105C45 hydrogenase expression formation protein (HypE) HO397_RS12990 ENOG4108JUA Transcriptional regulator HO397_RS12995 ENOG4105VXR cytoplasmic protein HO397_RS13010 ENOG4105MEW serine threonine protein phosphatase HO397_RS13015 ENOG4105MVE transcriptional regulator HO397_RS13020 ENOG4105ZXK Dehydrogenase HO397_RS13025 ENOG4105G63 Type III effector Hrp-dependent HO397_RS13030 ENOG4105FB2 class II Aldolase HO397_RS13035 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HO397_RS13040 ENOG4105C6Z Gluconate HO397_RS13045 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HO397_RS13050 ENOG4108K5P (LipO)protein HO397_RS13085 ENOG4105N0Z inner membrane protein ygbE HO397_RS13095 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HO397_RS13100 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HO397_RS13105 ENOG4108MXK alkaline phosphatase isozyme conversion HO397_RS13110 ENOG4108SER Transposase HO397_RS13115 ENOG4107635 Hok Gef family protein HO397_RS13125 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HO397_RS13135 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HO397_RS13140 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HO397_RS13145 ENOG4105WQV ferredoxin-like protein HO397_RS13150 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HO397_RS13155 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HO397_RS13160 ENOG4106IKH Electron transfer flavoprotein HO397_RS13165 ENOG4105C54 Major Facilitator superfamily HO397_RS13170 ENOG4107R3A FAD linked oxidase domain protein HO397_RS13175 ENOG4105CHR reductase HO397_RS13180 ENOG4108ITV Inner membrane protein yqcE HO397_RS13185 ENOG4108CWB sugar kinase ygcE HO397_RS13190 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HO397_RS13200 ENOG4105HA9 of methanol dehydrogenase type HO397_RS13215 ENOG4105DXN mazG family HO397_RS13220 ENOG4105MZG transcriptional modulator of maze toxin, mazf HO397_RS13225 ENOG4106A2Z transcriptional regulator antitoxin, MazE HO397_RS13230 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HO397_RS13235 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HO397_RS13240 ENOG4105BZU Histidine kinase HO397_RS13245 ENOG4105EQX glucarate dehydratase HO397_RS13250 ENOG4105EQX glucarate dehydratase HO397_RS13255 ENOG4105DJB Major Facilitator Superfamily HO397_RS13260 ENOG4105QDK Flavodoxin HO397_RS13265 ENOG4105DR9 pseudouridine synthase HO397_RS13270 ENOG4105WP7 tRNA pseudouridine synthase C HO397_RS13285 ENOG4105EWT decarboxylase family HO397_RS13290 ENOG4105C44 Serine transporter HO397_RS13295 ENOG4105EJQ L-serine dehydratase HO397_RS13305 ENOG4105C0A alcohol dehydrogenase HO397_RS13330 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HO397_RS13340 ENOG4105CNN ABC, transporter HO397_RS13345 ENOG4105C2J ABC transporter HO397_RS13350 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HO397_RS13355 ENOG4105CMG Carbohydrate kinase HO397_RS13365 ENOG4107EDW L-fucose operon activator HO397_RS13375 ENOG4105M08 Membrane HO397_RS13380 ENOG4105ETT transcriptional Regulator, LysR family HO397_RS13385 ENOG4105M5B (LipO)protein HO397_RS13390 ENOG4105C9B Cysteine desulfurase HO397_RS13395 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HO397_RS13400 ENOG4105CUZ uba thif-type nad fad binding protein HO397_RS13405 ENOG4105CA3 membrane-bound lytic murein transglycosylase HO397_RS13425 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HO397_RS13430 ENOG4108EKC n-acetylglutamate synthase HO397_RS13435 ENOG4107QYX exodeoxyribonuclease v alpha HO397_RS13440 ENOG4107QKA exodeoxyribonuclease V beta HO397_RS13445 ENOG4107QXK peptidase HO397_RS13450 ENOG4105DSY exodeoxyribonuclease V, gamma HO397_RS13455 ENOG4105RVB Prepilin peptidase dependent protein c HO397_RS13460 ENOG4105SEN Protein of unknown function (DUF2509) HO397_RS13465 ENOG4105JCS prepilin peptidase dependent protein HO397_RS13470 ENOG4105IPU prepilin peptidase dependent protein A HO397_RS13485 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HO397_RS13500 ENOG4105EE5 Membrane protein terC HO397_RS13505 ENOG4105SUV lipoprotein YgdR HO397_RS13510 ENOG4105CPC Aldo Keto reductase HO397_RS13515 ENOG4107S74 Lysophospholipid transporter LplT HO397_RS13525 ENOG41060NJ transcriptional regulator HO397_RS13535 ENOG4105RQF LysR family Transcriptional regulator HO397_RS13545 ENOG4107QNK )-transporter HO397_RS13570 ENOG4105CHU acetyl-coa acetyltransferase HO397_RS13575 ENOG4108MHD transport protein HO397_RS13580 ENOG4105ISV protein with bipartite regulator domain HO397_RS13600 ENOG4108K5P (LipO)protein HO397_RS13605 ENOG4105C7W Xanthine dehydrogenase HO397_RS13610 ENOG4108HR6 Dehydrogenase HO397_RS13615 ENOG4108UTP (2Fe-2S)-binding domain protein HO397_RS13620 ENOG4108JUB Transcriptional regulator HO397_RS13625 ENOG4105IW6 Carbamoyltransferase HO397_RS13630 ENOG4107RCH Diaminopropionate ammonia-lyase HO397_RS13635 ENOG4107S4Y M20 DapE family protein YgeY HO397_RS13645 ENOG4105C5B carbamate kinase HO397_RS13650 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HO397_RS13655 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HO397_RS13660 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HO397_RS13665 ENOG4105BZ8 glutamate synthase HO397_RS13670 ENOG4107UUR Chlorohydrolase aminohydrolase HO397_RS13675 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HO397_RS13680 ENOG4105C7W Xanthine dehydrogenase HO397_RS13685 ENOG4105C2W permease HO397_RS13690 ENOG4107QUY Guanine deaminase HO397_RS13695 ENOG4105C7N Xanthine uracil vitamin C permease HO397_RS13700 ENOG4108R8B oxidoreductase Fe-S subunit HO397_RS13705 ENOG4105BZ8 glutamate synthase HO397_RS13710 ENOG4105C2W permease HO397_RS13730 ENOG4105CRK lysyL-tRNA synthetase HO397_RS13740 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HO397_RS13745 ENOG4105T95 Thiol disulfide interChange protein HO397_RS13750 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HO397_RS13755 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HO397_RS13760 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HO397_RS13765 ENOG4105Y75 tpr repeat protein HO397_RS13775 ENOG4108UT2 hemolysin iii HO397_RS13785 ENOG4105CS2 ec 3.2.1.21 HO397_RS13790 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HO397_RS13815 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HO397_RS13820 ENOG4105D0A hydroxylase HO397_RS13825 ENOG4107RAQ aminopeptidase HO397_RS13845 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HO397_RS13855 ENOG4108JQ1 Dehydrogenase HO397_RS13875 ENOG4105D5P Methylmalonyl-coA mutase HO397_RS13880 ENOG4105DJT lAO AO transport system ATPase HO397_RS13885 ENOG4108M7F enoyl-CoA hydratase isomerase HO397_RS13890 ENOG4105CYC Transferase HO397_RS13895 ENOG4105DEQ transcriptional regulator HO397_RS13900 ENOG4105MPN Membrane HO397_RS13905 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HO397_RS13910 ENOG4105D64 Mechanosensitive ion channel HO397_RS13915 ENOG4105D2N Aldolase HO397_RS13930 ENOG4107Z1W Fructose transport system kinase HO397_RS13935 ENOG4108R4K DNA-binding, transcriptional regulator HO397_RS13940 ENOG4108Q8A Fructose-1,6-bisphosphatase HO397_RS13945 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HO397_RS13950 ENOG4105CTS PTS system mannitol-specific HO397_RS13955 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HO397_RS13960 ENOG4105CV1 Transketolase (EC 2.2.1.1) HO397_RS13965 ENOG4108K0D peptidase, M48 HO397_RS13975 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HO397_RS14000 ENOG4107QNK )-transporter HO397_RS14010 ENOG4105RWS endonuclease I HO397_RS14015 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HO397_RS14020 ENOG4105D7Z glutathione synthase HO397_RS14035 ENOG4105CZX twitching motility protein HO397_RS14040 ENOG4105DFA alanine racemase domain protein HO397_RS14045 ENOG4108VIA integral membrane protein HO397_RS14055 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HO397_RS14060 ENOG4105CSA Coproporphyrinogen iii oxidase HO397_RS14065 ENOG4106MH3 alpha helix chain HO397_RS14070 ENOG4105HDK L-asparaginase HO397_RS14075 ENOG4105K33 Periplasmic Protein HO397_RS14080 ENOG41090ED Protein with unknown function (DUF469) HO397_RS14090 ENOG4105CEN a g-specific adenine glycosylase HO397_RS14105 ENOG4105EAA nucleoside HO397_RS14110 ENOG4105CXN decarboxylase HO397_RS14115 ENOG4108UQV Membrane HO397_RS14150 ENOG4105C2X Arabinose 5-phosphate isomerase HO397_RS14155 ENOG4105ECX polysaccharide export HO397_RS14160 ENOG4107V1M polysaccharide export protein HO397_RS14165 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HO397_RS14170 ENOG4105E12 capsule polysaccharide HO397_RS14175 ENOG41084CK capsule polysaccharide HO397_RS14215 ENOG41090SZ ABC-2 type transporter HO397_RS14220 ENOG4105U1E general secretion pathway protein M HO397_RS14240 ENOG4105X5Z General secretion pathway protein I HO397_RS14250 ENOG4108VAU general secretion pathway protein G HO397_RS14255 ENOG4105D7Q type ii secretion system HO397_RS14260 ENOG4107QHF type ii secretion system protein e HO397_RS14275 ENOG410765S (LipO)protein HO397_RS14280 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HO397_RS14285 ENOG4105F88 accessory colonization factor AcfD HO397_RS14290 ENOG4105DAA L-lactate HO397_RS14295 ENOG4107QP3 malate synthase g HO397_RS14300 ENOG4108ZJF Glcg protein HO397_RS14305 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HO397_RS14310 ENOG4105EU8 FAD linked oxidase domain protein HO397_RS14315 ENOG4105CQB FAD linked oxidase domain protein HO397_RS14320 ENOG4108KWP DNA-binding transcriptional regulator GlcC HO397_RS14330 ENOG4107RCI amp-dependent synthetase and ligase HO397_RS14340 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HO397_RS14345 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HO397_RS14355 ENOG4108M8S permease YjgP YjgQ family protein HO397_RS14360 ENOG4108UUE Transcriptional regulator HO397_RS14370 ENOG4108S55 polysaccharide biosynthesis protein HO397_RS14375 ENOG4106FPV ATP-binding protein YghR HO397_RS14380 ENOG4108NDC ATP-binding protein yghS HO397_RS14385 ENOG4108GH0 ATP-binding protein yghT HO397_RS14390 ENOG4105CJ3 phosphate transporter HO397_RS14395 ENOG4106032 Glutathionylspermidine synthase HO397_RS14400 ENOG4105CYM Glutathione S-transferase HO397_RS14405 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HO397_RS14410 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HO397_RS14415 ENOG4108WGS hydrogenase 2-specific chaperone HO397_RS14420 ENOG4108USZ hydrogenase HO397_RS14425 ENOG4105DPX Hydrogenase, large subunit HO397_RS14430 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HO397_RS14435 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HO397_RS14440 ENOG4105E3S small subunit HO397_RS14445 ENOG410900S Protein of unknown function (DUF2623) HO397_RS14455 ENOG4105CPC Aldo Keto reductase HO397_RS14465 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HO397_RS14470 ENOG4108ZZF transport protein (ExbD) HO397_RS14475 ENOG4105CWK Biopolymer transport protein, ExbB HO397_RS14480 ENOG4105C28 cystathionine HO397_RS14485 ENOG4108K81 inner membrane protein YghB HO397_RS14490 ENOG4105CF7 AraC family transcriptional regulator HO397_RS14495 ENOG4108I6A alcohol dehydrogenase HO397_RS14500 ENOG4105CV8 reductase HO397_RS14505 ENOG4105ZKC Conserved Protein HO397_RS14515 ENOG4105CCT upf0313 protein HO397_RS14520 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HO397_RS14525 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HO397_RS14530 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HO397_RS14535 ENOG4108J59 Extracellular solute-binding protein, family 5 HO397_RS14540 ENOG4105WJ3 XRE family Transcriptional regulator HO397_RS14545 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation HO397_RS14550 ENOG4105F4I Transcriptional regulator HO397_RS14555 ENOG4105H4F exported protein HO397_RS14560 ENOG4105XJC Two component transcriptional regulator (Winged helix family HO397_RS14565 ENOG4105DHQ Histidine kinase HO397_RS14570 ENOG4107DEU Inner membrane protein YgiZ HO397_RS14575 ENOG4105NF4 modulator of drug activity HO397_RS14580 ENOG4105VRH Antibiotic biosynthesis monooxygenase HO397_RS14585 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HO397_RS14590 ENOG4105IPS esterase HO397_RS14595 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HO397_RS14600 ENOG4108SX3 cytoplasmic protein HO397_RS14605 ENOG41087AY ADP-Ribose pyrophosphatase HO397_RS14610 ENOG4105DFG type I secretion outer membrane protein HO397_RS14620 ENOG4106032 Glutathionylspermidine synthase HO397_RS14625 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HO397_RS14645 ENOG4105W0Z cytoplasmic protein HO397_RS14650 ENOG4105H8W Fimbrial protein HO397_RS14660 ENOG4108TTM chaperone HO397_RS14665 ENOG4108MY7 Fimbrial HO397_RS14675 ENOG4105PV3 Inner membrane protein yqiJ HO397_RS14680 ENOG4107S78 Band 7 protein HO397_RS14705 ENOG4105I7R Adenylate cyclase HO397_RS14710 ENOG4106MWK domain protein HO397_RS14725 ENOG4107ZVW dihydroneopterin aldolase HO397_RS14735 ENOG4105EJC lysr family transcriptional regulator HO397_RS14740 ENOG4106DSS Tartrate dehydratase subunit alpha HO397_RS14745 ENOG4107GFK fumarate HO397_RS14750 ENOG4107QPK )-transporter HO397_RS14755 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HO397_RS14765 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HO397_RS14770 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HO397_RS14785 ENOG4105Q26 Siderophore-interacting protein HO397_RS14790 ENOG4105NTW Transcriptional regulator HO397_RS14795 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HO397_RS14800 ENOG4105C8Y Acetylornithine aminotransferase HO397_RS14805 ENOG4108Y51 tRNA-binding protein HO397_RS14810 ENOG4105CQ4 Transcriptional regulator HO397_RS14815 ENOG4105CNT hydrolase family 2 HO397_RS14820 ENOG4105FK9 beta-D-galactosidase beta subunit HO397_RS14825 ENOG4105E5D amino acid HO397_RS14830 ENOG4107W6W Conserved Protein HO397_RS14835 ENOG4107WCA isomerase HO397_RS14840 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HO397_RS14845 ENOG4108Z3N Transcriptional regulator HO397_RS14850 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase HO397_RS14855 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HO397_RS14860 ENOG4108VKG metal-dependent hydrolase HO397_RS14865 ENOG4108UB4 uncharacterized protein ygjQ HO397_RS14870 ENOG4105EE0 oxidoreductase HO397_RS14875 ENOG4105DU1 integral membrane protein, terc HO397_RS14880 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HO397_RS14885 ENOG4105P66 Membrane HO397_RS14890 ENOG4105CTX dehydratase HO397_RS14900 ENOG4105DPW Major facilitator superfamily MFS_1 HO397_RS14905 ENOG4107YCY Transcriptional regulator HO397_RS14910 ENOG4106W5V Membrane HO397_RS14915 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HO397_RS14920 ENOG4105WAY exported protein HO397_RS14925 ENOG4105NE1 Conserved Protein HO397_RS14930 ENOG41090KG Inner membrane protein YqjE HO397_RS14935 ENOG4105YJD HO397_RS14940 ENOG4108VBZ doxx family HO397_RS14945 ENOG4105CHF Glutathione S-transferase HO397_RS14950 ENOG4105KAF membrAne HO397_RS14955 ENOG4105KAF membrAne HO397_RS14960 ENOG4105CWB LysR family transcriptional Regulator HO397_RS14965 ENOG4108CNN domain protein HO397_RS14970 ENOG4106D80 Uncharacterized protein YhaL HO397_RS14980 ENOG4105C44 Serine transporter HO397_RS14985 ENOG4105EJQ L-serine dehydratase HO397_RS14990 ENOG4105KME endoribonuclease L-psp HO397_RS14995 ENOG4105C6N Formate acetyltransferase HO397_RS15000 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HO397_RS15010 ENOG4105C7B Threonine dehydratase HO397_RS15015 ENOG410811B TRANSCRIPTIONal HO397_RS15040 ENOG4105BZW Glycerate kinase HO397_RS15045 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HO397_RS15055 ENOG4105DJB Major Facilitator Superfamily HO397_RS15060 ENOG4105CTX dehydratase HO397_RS15065 ENOG4105ZEG Suppressor protein HO397_RS15075 ENOG4105E98 transcriptional regulator DeoR family HO397_RS15085 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HO397_RS15095 ENOG4105F3R pts system mannose fructose sorbose family iid HO397_RS15100 ENOG4108YTN IIa component HO397_RS15105 ENOG4105CE4 GlcNAc 6-P deacetylase HO397_RS15110 ENOG4105E70 isomerase HO397_RS15120 ENOG4108UZY PTS System HO397_RS15125 ENOG4105ETZ PTS System HO397_RS15130 ENOG4105F3R pts system mannose fructose sorbose family iid HO397_RS15135 ENOG4106HBN Galactosamine-6-phosphate isomerase HO397_RS15140 ENOG4105Q10 Fimbrial-like protein HO397_RS15145 ENOG4108VCD Chaperone HO397_RS15150 ENOG4105CW0 outer membrane usher protein HO397_RS15155 ENOG4105I74 Fimbrial protein HO397_RS15160 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HO397_RS15165 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HO397_RS15170 ENOG41082RQ UPF0102 protein HO397_RS15180 ENOG4105W4M Transport-associated protein HO397_RS15185 ENOG4107S21 permease HO397_RS15190 ENOG4105K4T epimerase HO397_RS15195 ENOG4107R7Y intracellular protease Pfpi family HO397_RS15210 ENOG4108YYD acetyltransferase HO397_RS15230 ENOG4105DEN Luciferase family HO397_RS15235 ENOG4105CIC tryptophan-specific transport protein HO397_RS15240 ENOG4105C1J atp-dependent rna helicase HO397_RS15280 ENOG4105CHV Transcription elongation factor NusA HO397_RS15300 ENOG4105DIJ Phosphoethanolamine transferase HO397_RS15310 ENOG4105NTZ Preprotein translocase subunit SecG HO397_RS15320 ENOG4105EEI dihydropteroate synthase HO397_RS15325 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HO397_RS15335 ENOG4105HBR Rna-binding protein HO397_RS15340 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HO397_RS15345 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HO397_RS15355 ENOG4105QYV Membrane HO397_RS15370 ENOG4105EAH synthase HO397_RS15375 ENOG4105HVQ Regulatory factor of maltose metabolism HO397_RS15385 ENOG4105VFK BolA family HO397_RS15390 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HO397_RS15395 ENOG4105E3I toluene tolerance HO397_RS15400 ENOG4107PE3 Mammalian cell entry related domain protein HO397_RS15405 ENOG4105CY3 ABC transporter, permease HO397_RS15410 ENOG4105DHJ ABC, transporter HO397_RS15415 ENOG4105FEU K -dependent Na -Ca exchanger HO397_RS15420 ENOG4105C2X Arabinose 5-phosphate isomerase HO397_RS15430 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HO397_RS15435 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HO397_RS15440 ENOG4108IUZ ABC transporter HO397_RS15445 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HO397_RS15450 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HO397_RS15455 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HO397_RS15465 ENOG41080Z8 PHOSPHOCARRIER protein HO397_RS15470 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HO397_RS15480 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HO397_RS15485 ENOG4105BZU Histidine kinase HO397_RS15490 ENOG4105N5T Radical SAM Protein HO397_RS15495 ENOG4105CBC glutamate synthase HO397_RS15500 ENOG4105BZ8 glutamate synthase HO397_RS15505 ENOG4105DFS Conserved Protein HO397_RS15515 ENOG4108R66 Conserved Protein HO397_RS15520 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HO397_RS15530 ENOG4105JHE Major Facilitator Superfamily HO397_RS15545 ENOG4105CEE C4-dicarboxylate transporter HO397_RS15550 ENOG4105KB2 stringent starvation protein b HO397_RS15555 ENOG4107MKT Stringent starvation protein a HO397_RS15570 ENOG4105D6Z AFG1 family ATPase HO397_RS15575 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HO397_RS15580 ENOG4105C0H protease HO397_RS15585 ENOG4105C0H protease HO397_RS15600 ENOG4105RID UPF0379 protein yhcN HO397_RS15605 ENOG4105UNR (Barnase) inhibitor HO397_RS15620 ENOG4105ZQC membrane protein AaeX HO397_RS15625 ENOG4105CR8 Transcriptional regulator HO397_RS15630 ENOG4105D1U peptidase U62 modulator of DNA gyrase HO397_RS15635 ENOG4105QD6 exported protein HO397_RS15640 ENOG4105C03 ribonuclease HO397_RS15645 ENOG4108Z03 MAF-like protein HO397_RS15650 ENOG4105VQ7 Rod shape-determining protein MreD HO397_RS15655 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HO397_RS15665 ENOG41062P1 Diguanylate cyclase phosphodiesterase HO397_RS15670 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HO397_RS15675 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HO397_RS15680 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HO397_RS15685 ENOG4105RG0 Membrane HO397_RS15690 ENOG4108IA2 Sodium pantothenate symporter HO397_RS15700 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HO397_RS15710 ENOG4105CEC DNA methylase N-4 N-6 HO397_RS15715 ENOG41061ME transport protein HO397_RS15720 ENOG4108XG4 DNA-binding transcriptional regulator HO397_RS15725 ENOG4105C1P efflux transporter, rnd family, mfp subunit HO397_RS15730 ENOG4105BZS acriflavin resistance protein HO397_RS15735 ENOG4105XCM membrane LIPOPROTEIN HO397_RS15745 ENOG4105EZ7 amino acid ABC transporter HO397_RS15750 ENOG4105DRP amino acid AbC transporter HO397_RS15755 ENOG4105CDA abc transporter atp-binding protein HO397_RS15795 ENOG4108Z0R Transferase HO397_RS15800 ENOG4105SG3 Protein of unknown function (DUF1488) HO397_RS15815 ENOG4108WI1 Dna topoisomerase HO397_RS15825 ENOG4105C79 DNA protecting protein DprA HO397_RS15845 ENOG4105C1A potassium transporter peripheral membrane HO397_RS15855 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HO397_RS15860 ENOG4105W1Y Transcriptional regulator HO397_RS15865 ENOG4105VTS DnaJ-like, subfamily C HO397_RS15895 ENOG41067V7 50S ribosomal protein L36 HO397_RS15900 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HO397_RS15945 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HO397_RS15990 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HO397_RS16010 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication HO397_RS16015 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression HO397_RS16020 ENOG4107KSE General secretion pathway protein C HO397_RS16025 ENOG4105GVR general secretion pathway protein D HO397_RS16030 ENOG4107QHF type ii secretion system protein e HO397_RS16035 ENOG4105D7Q type ii secretion system HO397_RS16040 ENOG4108VAU general secretion pathway protein G HO397_RS16045 ENOG41069X0 general secretion pathway protein h HO397_RS16060 ENOG4105R04 type II secretion system protein K HO397_RS16065 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HO397_RS16075 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HO397_RS16080 ENOG4108UQY Iron-storage protein HO397_RS16085 ENOG4105W53 bacterioferritin-associated ferredoxin HO397_RS16090 ENOG4108NNZ chitinase HO397_RS16130 ENOG4105WWK YheO domain protein HO397_RS16135 ENOG4108V1T peptidylprolyl cis-trans isomerase HO397_RS16145 ENOG4108YZY peptidylprolyl cis-trans isomerase HO397_RS16150 ENOG4105VKU nucleicacid-binding protein HO397_RS16165 ENOG4105C5H ABC transporter HO397_RS16170 ENOG4105DNZ Alpha Beta Hydrolase HO397_RS16180 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HO397_RS16185 ENOG4108UKZ OsmC family HO397_RS16195 ENOG410613R integral membrane protein, YccS YhfK family HO397_RS16200 ENOG4105C8Y Acetylornithine aminotransferase HO397_RS16205 ENOG4105DDQ anthranilate synthase HO397_RS16210 ENOG4105MZU cell filamentation protein HO397_RS16220 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HO397_RS16230 ENOG4107QZF nitrite reductase NADPH large subunit HO397_RS16235 ENOG4105WZK nitrite reductase NADPH small subunit HO397_RS16240 ENOG4107V9H nitrite transporter HO397_RS16250 ENOG4105VYH HO397_RS16255 ENOG4107QHQ amino acid HO397_RS16260 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HO397_RS16265 ENOG4107Y0V Not clear, may be involved in an isomerization step HO397_RS16270 ENOG4108KPW sugar kinase HO397_RS16275 ENOG4105FDP GntR family transcriptional regulator HO397_RS16280 ENOG4106PKC pyridoxal phosphate binding HO397_RS16295 ENOG4106M0N transport system permease protein HO397_RS16300 ENOG4105MUZ Protein of unknown function DUF2620 HO397_RS16305 ENOG41080QX K07048 phosphotriesterase-related protein HO397_RS16310 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HO397_RS16315 ENOG4108626 Racemase HO397_RS16320 ENOG4105RMW regulation of transcription, DNA-dependent HO397_RS16325 ENOG4108M21 HO397_RS16330 ENOG4105C31 Tryptophanyl-tRNA synthetase HO397_RS16335 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HO397_RS16340 ENOG4105DJV ribulose-phosphate 3-epimerase HO397_RS16345 ENOG4105DFE Dna adenine methylase HO397_RS16350 ENOG4105EGB membrane protein DamX HO397_RS16365 ENOG4105E4G Type IV pilus HO397_RS16370 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HO397_RS16375 ENOG4105XPX DNA utilization protein HofO HO397_RS16380 ENOG41065NF Fimbrial assembly family protein HO397_RS16385 ENOG4108U1Q Pilus assembly protein HO397_RS16390 ENOG4108JQC penicillin-binding protein 1A HO397_RS16395 ENOG4107RK2 ADP-ribose diphosphatase NudE HO397_RS16400 ENOG4105DQY intracellular growth attenuator HO397_RS16405 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HO397_RS16410 ENOG4105VEJ Heat shock protein HO397_RS16420 ENOG4108MAJ Membrane HO397_RS16430 ENOG4105E0F Histidine kinase HO397_RS16440 ENOG4108RRZ Transcription elongation factor GreB HO397_RS16445 ENOG4105BZM domain protein HO397_RS16450 ENOG4105XFK Ferrous iron transport protein A HO397_RS16455 ENOG4105CE1 Ferrous iron transport protein b HO397_RS16465 ENOG4105DNE Transposase HO397_RS16475 ENOG4105MJ2 Competence protein HO397_RS16485 ENOG4105C6Z Gluconate HO397_RS16490 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HO397_RS16495 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HO397_RS16510 ENOG4105E0Y RtcB Protein HO397_RS16515 ENOG4105CYB regulatoR HO397_RS16520 ENOG4105E98 transcriptional regulator DeoR family HO397_RS16535 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HO397_RS16555 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HO397_RS16580 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HO397_RS16585 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HO397_RS16590 ENOG4105C6Z Gluconate HO397_RS16595 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HO397_RS16600 ENOG4105DIQ Transcriptional regulator HO397_RS16605 ENOG4105C2I pirin domain protein HO397_RS16610 ENOG4105D9R oxidoreductase HO397_RS16615 ENOG4105WCN acetyltransferase HO397_RS16620 ENOG4105GMB type VI secretion system effector, hcp1 family HO397_RS16635 ENOG4106FA4 HO397_RS16640 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HO397_RS16645 ENOG4105WC8 Conserved Protein HO397_RS16650 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HO397_RS16655 ENOG4108IJ9 (ABC) transporter HO397_RS16660 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HO397_RS16665 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HO397_RS16670 ENOG4105BZ7 extracellular solute-binding protein family 1 HO397_RS16675 ENOG4108IV0 ABC, transporter HO397_RS16680 ENOG4105C0Z ABC transporter HO397_RS16685 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HO397_RS16690 ENOG4105C32 Amino acid ABC transporter (Permease) HO397_RS16695 ENOG4105CP9 extracellular ligand-binding receptor HO397_RS16700 ENOG4105U59 -acetyltransferase HO397_RS16705 ENOG4105CP9 extracellular ligand-binding receptor HO397_RS16710 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HO397_RS16715 ENOG4105CRP Part of the ABC transporter FtsEX involved in HO397_RS16720 ENOG4105CAK Cell division ATP-binding protein ftsE HO397_RS16725 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HO397_RS16730 ENOG4106H78 methyltransferase HO397_RS16735 ENOG4105MG3 Membrane HO397_RS16745 ENOG4107FS9 Membrane HO397_RS16760 ENOG4105EX9 Membrane HO397_RS16765 ENOG4108W1V Lipoprotein HO397_RS16770 ENOG4105F9N Major Facilitator Superfamily HO397_RS16775 ENOG4105DSF transport protein HO397_RS16780 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HO397_RS16785 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HO397_RS16790 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HO397_RS16795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HO397_RS16800 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HO397_RS16815 ENOG4105CNA YD repeat protein HO397_RS16825 ENOG4105NUP lyase containing HEAT-repeat HO397_RS16830 ENOG410600T transposase HO397_RS16835 ENOG4105CMI transporter HO397_RS16840 ENOG4105CJ1 ABC, transporter HO397_RS16845 ENOG4105D0S secretion protein (HlyD HO397_RS16860 ENOG4107UNS conserved inner membrane protein HO397_RS16865 ENOG4105CBX hi0933 family HO397_RS16870 ENOG4105CJ3 phosphate transporter HO397_RS16885 ENOG4105DUX Transporter HO397_RS16895 ENOG4105DGW oligopeptidase A HO397_RS16900 ENOG4105D6S protein involved in catabolism of external DNA HO397_RS16905 ENOG4105DC8 reductase HO397_RS16915 ENOG4105KBH arsR family transcriptional regulator HO397_RS16920 ENOG4107R5R arsenical pump membrane protein HO397_RS16925 ENOG4105K89 arsenate reductase HO397_RS16935 ENOG4105Y4Z Outer Membrane Lipoprotein HO397_RS16945 ENOG4105KT7 mgtC SapB transporter HO397_RS16950 ENOG4105XXV Acid-resistance protein HO397_RS16955 ENOG41060V2 Acid-resistance protein HO397_RS16960 ENOG4108YK4 Acid-resistance membrane protein HO397_RS16965 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HO397_RS16975 ENOG4105C1P efflux transporter, rnd family, mfp subunit HO397_RS16980 ENOG4105BZS acriflavin resistance protein HO397_RS16990 ENOG4108NKV transcriptional regulator HO397_RS16995 ENOG4105CVK Glutamate decarboxylase HO397_RS17000 ENOG4105CA0 peroxidase HO397_RS17010 ENOG4106S2D Transcriptional regulator HO397_RS17015 ENOG4105CBN LysR family transcriptional regulator HO397_RS17020 ENOG4107H3J ribonuclease HO397_RS17025 ENOG4105CSH Transporter HO397_RS17030 ENOG41066T0 asmA family HO397_RS17035 ENOG4105CMB EAL domain-containing protein HO397_RS17045 ENOG4105CS0 peptidase HO397_RS17055 ENOG4105BZU Histidine kinase HO397_RS17060 ENOG4105EJG cellulose synthase HO397_RS17065 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HO397_RS17070 ENOG4107EEX Cellulose synthase regulator protein HO397_RS17075 ENOG4107QZ7 Cellulose synthase catalytic subunit HO397_RS17085 ENOG410661M cytoplasmic protein HO397_RS17090 ENOG4105U74 cellulose biosynthesis protein BcsE HO397_RS17095 ENOG4105WQA Cellulose biosynthesis protein BcsF HO397_RS17100 ENOG4105D1V cellulose synthase operon protein YhjU HO397_RS17120 ENOG4105C44 Serine transporter HO397_RS17125 ENOG4108JQ7 (ABC) transporter HO397_RS17130 ENOG4105C3U ABC transporter HO397_RS17135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HO397_RS17140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HO397_RS17145 ENOG4105DEF Extracellular solute-binding protein, family 5 HO397_RS17160 ENOG4105DIJ Phosphoethanolamine transferase HO397_RS17165 ENOG4105FCD Major Facilitator HO397_RS17170 ENOG4105EAX Putative lipase HO397_RS17175 ENOG4108R3E Dna-3-methyladenine glycosylase i HO397_RS17180 ENOG4105HNP -acetyltransferase HO397_RS17185 ENOG4107QY8 reductase HO397_RS17190 ENOG4108ZG0 Ompa motb domain protein HO397_RS17200 ENOG4106JH6 (LipO)protein HO397_RS17205 ENOG4105MVF Transcriptional regulator HO397_RS17215 ENOG41060TC Hok gef cell toxic protein HO397_RS17240 ENOG4105MEV Acyl-transferase HO397_RS17245 ENOG4108Z12 YiaAB two helix domain-containing protein HO397_RS17250 ENOG410688U Inner membrane protein yiaB HO397_RS17255 ENOG4105CMG Carbohydrate kinase HO397_RS17265 ENOG4105DFW ABC transporter HO397_RS17275 ENOG4108HWW ABC transporter HO397_RS17280 ENOG4105T16 Transcriptional regulator (AraC family) HO397_RS17285 ENOG4108UR8 BAX protein HO397_RS17290 ENOG4107T9C Alpha amylase catalytic region HO397_RS17295 ENOG4105JKW Valine--pyruvate aminotransferase HO397_RS17300 ENOG4108XIB electron transport protein ysaA HO397_RS17305 ENOG4105J4Q Transcriptional regulator HO397_RS17315 ENOG4108R66 Conserved Protein HO397_RS17320 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HO397_RS17325 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HO397_RS17330 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HO397_RS17335 ENOG4105CMG Carbohydrate kinase HO397_RS17340 ENOG4105H6Q decarboxylase HO397_RS17345 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HO397_RS17350 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HO397_RS17360 ENOG4105CT4 transporter HO397_RS17370 ENOG4105GNX MltA-interacting MipA family protein HO397_RS17375 ENOG4108Q2M Transcriptional regulator HO397_RS17380 ENOG4105EFX secretion protein, HlyD family HO397_RS17385 ENOG4105KK7 inner membrane protein YiaW HO397_RS17395 ENOG4105C26 Dehydrogenase HO397_RS17400 ENOG4105C0A alcohol dehydrogenase HO397_RS17405 ENOG4105EM7 Selenocysteine-specific translation elongation factor HO397_RS17415 ENOG4108U78 Glutathione S-transferase HO397_RS17420 ENOG4105CNA YD repeat protein HO397_RS17420 ENOG4105CNA YD repeat protein HO397_RS17425 ENOG4105NUP lyase containing HEAT-repeat HO397_RS17445 ENOG4105EFX secretion protein, HlyD family HO397_RS17450 ENOG4105FP6 Protein of unknown function (DUF3302) HO397_RS17455 ENOG4105CTS PTS system mannitol-specific HO397_RS17465 ENOG4105E61 Mannitol repressor protein HO397_RS17475 ENOG4108YYI Protein of unknown function (DUF2810) HO397_RS17480 ENOG4108WY4 inner membrane lipoprotein HO397_RS17485 ENOG4105EUR Domain-Containing protein HO397_RS17490 ENOG4105DAA L-lactate HO397_RS17495 ENOG41073TP transcriptional regulator HO397_RS17505 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HO397_RS17510 ENOG4105D7W serine acetyltransferase HO397_RS17525 ENOG4105VW4 glutaredoxin 3 HO397_RS17530 ENOG4107YZP Rhodanese domain protein HO397_RS17540 ENOG41063SB peptidase HO397_RS17545 ENOG4105PXI polysaccharide deacetylase HO397_RS17550 ENOG4105K64 Glycosyl transferase, family 2 HO397_RS17560 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HO397_RS17570 ENOG4105XA0 heptosyltransferase ii HO397_RS17575 ENOG4105D16 lipopolysaccharide heptosyltransferase i HO397_RS17580 ENOG41068PG O-Antigen polymerase HO397_RS17585 ENOG4105K64 Glycosyl transferase, family 2 HO397_RS17590 ENOG4105X1N Glycosyl transferase family 8 HO397_RS17615 ENOG4106AH0 Glycosyl Transferase HO397_RS17620 ENOG4107543 (lipo)polysaccharide HO397_RS17625 ENOG4107RJ7 Glycosyl transferase (Group 1 HO397_RS17630 ENOG4105DKP glycosyl transferase, family 9 HO397_RS17635 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HO397_RS17655 ENOG4105KDC 50s ribosomal protein l28 HO397_RS17665 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HO397_RS17670 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HO397_RS17690 ENOG4105DSJ YicC domain protein HO397_RS17700 ENOG4105F5P DNA-damage-inducible protein d HO397_RS17705 ENOG4105EN6 Membrane HO397_RS17710 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HO397_RS17715 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HO397_RS17725 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HO397_RS17730 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HO397_RS17735 ENOG4105CB5 ATP-dependent DNA helicase recG HO397_RS17745 ENOG4105D6U Sodium Glutamate Symporter HO397_RS17750 ENOG4105C2W permease HO397_RS17755 ENOG4105JV1 AsmA family HO397_RS17760 ENOG4105CJQ hydrolase, family 31 HO397_RS17765 ENOG4105CT4 transporter HO397_RS17775 ENOG4105DFP Integrase HO397_RS17785 ENOG4105CQ4 Transcriptional regulator HO397_RS17790 ENOG4105DPW Major facilitator superfamily MFS_1 HO397_RS17800 ENOG4108UUM single-stranded DNA-binding protein HO397_RS17880 ENOG4105S8Q sugar efflux transporter HO397_RS17885 ENOG4108UZ3 Transporter HO397_RS17890 ENOG4105D01 (LipO)protein HO397_RS17895 ENOG4105T8A Uncharacterized protein YicS HO397_RS17905 ENOG4108SAJ Protein of unknown function (DUF1198) HO397_RS17910 ENOG4105C7N Xanthine uracil vitamin C permease HO397_RS17915 ENOG4105CPN adenine deaminase HO397_RS17920 ENOG4105CXY transporter HO397_RS17925 ENOG4105CXY transporter HO397_RS17930 ENOG4105BZU Histidine kinase HO397_RS17935 ENOG4108KX4 response regulator HO397_RS17940 ENOG4105M71 acetolactate synthase 1 regulatory subunit HO397_RS17945 ENOG4105C7K acetolactate synthase HO397_RS17960 ENOG4105E5M Multidrug resistance protein D HO397_RS17965 ENOG4105J13 transcriptional regulator HO397_RS17970 ENOG4105JP4 Inner membrane protein yidG HO397_RS17975 ENOG4105VG5 Membrane HO397_RS17980 ENOG4106DRA Inner membrane protein YidI HO397_RS17985 ENOG4105CBG Sulfatase HO397_RS17990 ENOG4107RUZ Sss sodium solute transporter superfamily HO397_RS17995 ENOG4108AHD Transcriptional regulator HO397_RS18000 ENOG4105F8D glycoside hydrolase family 4 HO397_RS18005 ENOG4105CI1 PTS System HO397_RS18030 ENOG4105R2A (LipO)protein HO397_RS18035 ENOG4105D99 atp gtp-binding protein HO397_RS18045 ENOG4105DJB Major Facilitator Superfamily HO397_RS18055 ENOG4108RTU Aldolase HO397_RS18060 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HO397_RS18065 ENOG4105EMF GntR family transcriptional regulator HO397_RS18070 ENOG410657R replicase EC 2.7 HO397_RS18075 ENOG410667J hydrolase HO397_RS18080 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HO397_RS18085 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HO397_RS18095 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HO397_RS18110 ENOG4105VG0 50S ribosomal protein l34 HO397_RS18145 ENOG4108P6C Tryptophan transporter of low affinity HO397_RS18160 ENOG4105E8Q phosphopantetheinyl transferase HO397_RS18165 ENOG4108YYH Nadph-dependent fmn reductase HO397_RS18170 ENOG4105C7N Xanthine uracil vitamin C permease HO397_RS18175 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HO397_RS18185 ENOG4106611 bacteriocin immunity HO397_RS18190 ENOG4107VKM 6-phosphogluconolactonase HO397_RS18195 ENOG4105DYC esterase HO397_RS18205 ENOG4105CS2 ec 3.2.1.21 HO397_RS18210 ENOG4105C5Y PTS System HO397_RS18215 ENOG4105CID antiterminator HO397_RS18220 ENOG4108UTW Plays a role in the regulation of phosphate uptake HO397_RS18225 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HO397_RS18230 ENOG4105E2Z phosphate ABC transporter (Permease HO397_RS18235 ENOG4105C8U phosphate abc transporter HO397_RS18240 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HO397_RS18245 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HO397_RS18295 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HO397_RS18310 ENOG4105QTB Flavodoxin HO397_RS18315 ENOG4108VVK transcriptional Regulator, AsnC HO397_RS18330 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) HO397_RS18355 ENOG4105C2J ABC transporter HO397_RS18360 ENOG4105CNN ABC, transporter HO397_RS18365 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HO397_RS18370 ENOG4108RVA ribokinase HO397_RS18375 ENOG4105ETE Transcriptional regulator (LacI family HO397_RS18380 ENOG4105C0R drug resistance transporter emrb qaca subfamily HO397_RS18385 ENOG4107EJG GntR family transcriptional regulator HO397_RS18425 ENOG4108WFC UPF0438 protein yifE HO397_RS18430 ENOG4105C0P Mg chelatase subunit ChlI HO397_RS18450 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HO397_RS18455 ENOG4105CM2 brancheD-chain amino acid aminotransferase HO397_RS18465 ENOG4105C7B Threonine dehydratase HO397_RS18470 ENOG4105EMY transcriptional regulator HO397_RS18480 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HO397_RS18490 ENOG4105C4R Atp-dependent dna helicase HO397_RS18515 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HO397_RS18520 ENOG4105ESV Glycosyl transferase, family 4 HO397_RS18525 ENOG4105SFE lipopolysaccharide biosynthesis protein HO397_RS18530 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HO397_RS18535 ENOG4107QQG Dehydrogenase HO397_RS18540 ENOG4105C1B dTDP-glucose 4-6-dehydratase HO397_RS18545 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HO397_RS18550 ENOG4108WJ1 acetyltransferase HO397_RS18555 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HO397_RS18560 ENOG4105EGZ biosynthesis protein HO397_RS18565 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HO397_RS18580 ENOG4105C85 amino acid HO397_RS18605 ENOG4105C4X radical SAM domain protein HO397_RS18610 ENOG4105ENH Sulfatase HO397_RS18615 ENOG410601J HemY protein HO397_RS18620 ENOG4105ECF c-methyltransferase HO397_RS18625 ENOG41076E6 Uroporphyrinogen-III Synthase HO397_RS18635 ENOG4107T0K Adenylate cyclase HO397_RS18650 ENOG4105S7Z (LipO)protein HO397_RS18660 ENOG4105CT0 Protein of unknown function, DUF484 HO397_RS18670 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HO397_RS18675 ENOG4105C4R Atp-dependent dna helicase HO397_RS18680 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HO397_RS18685 ENOG4108T58 Mg2 transport protein CorA HO397_RS18690 ENOG4107QUT magnesium and cobalt transport protein CorA HO397_RS18705 ENOG4107QUT magnesium and cobalt transport protein CorA HO397_RS18710 ENOG4105NRM Membrane HO397_RS18720 ENOG4105FR1 rard protein HO397_RS18725 ENOG4108VUY thioesterase Superfamily protein HO397_RS18730 ENOG4105HDD phospholipase HO397_RS18735 ENOG4105C9U ATP-dependent DNA helicase RecQ HO397_RS18740 ENOG4105CCF Lysine exporter protein (Lyse ygga) HO397_RS18745 ENOG410829K Lysine exporter protein (Lyse ygga) HO397_RS18750 ENOG4108EUD Lysophospholipase HO397_RS18755 ENOG4105DQF Hydrolase HO397_RS18760 ENOG4105EMK carboxylate amino acid amine transporter HO397_RS18765 ENOG4105DZ2 Transcriptional regulator HO397_RS18770 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HO397_RS18775 ENOG4105F52 Transcriptional regulator HO397_RS18780 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HO397_RS18790 ENOG4105C5B carbamate kinase HO397_RS18795 ENOG4107REC cytoplasmic protein HO397_RS18800 ENOG4107R1Q Membrane protein FdrA HO397_RS18810 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HO397_RS18815 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HO397_RS18820 ENOG4108I5U Uridine phosphorylase HO397_RS18835 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HO397_RS18840 ENOG4108RTU Aldolase HO397_RS18845 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HO397_RS18850 ENOG4107HP6 Transcriptional regulator HO397_RS18855 ENOG4105CGY Dna recombination protein HO397_RS18865 ENOG4105JC1 sterol-binding domain protein HO397_RS18875 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HO397_RS18880 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HO397_RS18885 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HO397_RS18890 ENOG4105F8V Hydrolase, tatD family HO397_RS18895 ENOG4105MDZ Transcriptional activator rfaH HO397_RS18900 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HO397_RS18905 ENOG4108EX3 reductase HO397_RS18915 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HO397_RS18925 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HO397_RS18930 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HO397_RS18935 ENOG4108RR8 protoporphyrinogen oxidase HO397_RS18965 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HO397_RS18970 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HO397_RS18975 ENOG4105PC1 Conserved Protein HO397_RS18980 ENOG4105E27 serine threonine protein kinase HO397_RS18985 ENOG4108Z33 Thiol disulfide Interchange Protein HO397_RS18995 ENOG4106HNH Acyl-transferase HO397_RS19000 ENOG4105C2M dna polymerase I HO397_RS19015 ENOG4105D4P Coproporphyrinogen iii oxidase HO397_RS19020 ENOG4106FIY HO397_RS19025 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HO397_RS19030 ENOG4105CUX Signal transduction histidine kinase HO397_RS19035 ENOG4105C5F glutamine synthetase HO397_RS19040 ENOG4105CI3 gtp-binding protein typa HO397_RS19045 ENOG4108K85 Transcriptional regulator HO397_RS19050 ENOG4108KHF Resistance protein HO397_RS19055 ENOG4105R9B Major Facilitator HO397_RS19060 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HO397_RS19065 ENOG4105CT4 transporter HO397_RS19070 ENOG4105CT4 transporter HO397_RS19080 ENOG4107WI4 Aldose-1-epimerase HO397_RS19085 ENOG4107QKS N-acylglucosamine 2-epimerase HO397_RS19090 ENOG4105D2M Aldolase HO397_RS19095 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HO397_RS19100 ENOG4108MGF sugar kinase HO397_RS19105 ENOG4105E98 transcriptional regulator DeoR family HO397_RS19110 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HO397_RS19125 ENOG4105SUU thioesterase domain HO397_RS19135 ENOG41068KX affects formate dehydrogenase-N HO397_RS19145 ENOG4108MG3 formate dehydrogenase HO397_RS19150 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HO397_RS19160 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HO397_RS19165 ENOG4108V87 frv operon regulatory protein HO397_RS19170 ENOG4106C3V frv operon regulatory protein HO397_RS19175 ENOG4105CN9 Peptidase m42 family protein HO397_RS19180 ENOG4105DM4 PTS System HO397_RS19185 ENOG41064BA PTS system, fructose-specific, IIA component HO397_RS19230 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HO397_RS19240 ENOG4108RPX mosc domain containing protein HO397_RS19245 ENOG4105E0F Histidine kinase HO397_RS19250 ENOG4105E3W Two component transcriptional regulator (Winged helix family HO397_RS19255 ENOG4105FMW periplasmic HO397_RS19270 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HO397_RS19285 ENOG4105EBK exported protein HO397_RS19290 ENOG4108VTS Membrane HO397_RS19295 ENOG41065TG regulatoR HO397_RS19305 ENOG4105DP0 ferredoxin-NADP reductase HO397_RS19310 ENOG4105CBT Fructose-1,6-bisphosphatase HO397_RS19320 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HO397_RS19335 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HO397_RS19350 ENOG41063M6 Cell Division Protein HO397_RS19355 ENOG4105ETE Transcriptional regulator (LacI family HO397_RS19360 ENOG4105C25 Primosomal protein n' HO397_RS19375 ENOG4107S01 Repressor protein MetJ HO397_RS19385 ENOG4105C28 cystathionine HO397_RS19390 ENOG4105CFH Aspartokinase HO397_RS19395 ENOG4105SYT Methylenetetrahydrofolate reductase HO397_RS19405 ENOG4108Q5Y Membrane HO397_RS19410 ENOG4108XC3 NADH ubiquinone oxidoreductase HO397_RS19415 ENOG4105DCT glycerol dehydrogenase HO397_RS19420 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HO397_RS19425 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HO397_RS19430 ENOG4105DM4 PTS System HO397_RS19435 ENOG4108YRF PTS System HO397_RS19445 ENOG4108AHH pyruvate formate lyase II activase HO397_RS19450 ENOG4108XCZ PTS System HO397_RS19455 ENOG4106R3P AraC family transcriptional regulator HO397_RS19460 ENOG4105DIJ Phosphoethanolamine transferase HO397_RS19475 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HO397_RS19490 ENOG4105C5Q Transcriptional regulator HO397_RS19500 ENOG4105EJ2 Transcriptional regulator HO397_RS19505 ENOG4108Y73 Membrane HO397_RS19520 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HO397_RS19550 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HO397_RS19585 ENOG4105PM1 preprotein translocase subunit SecE HO397_RS19590 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HO397_RS19625 ENOG410645W Thiamin biosynthesis protein ThiH HO397_RS19630 ENOG4105D41 biosynthesis protein thiH HO397_RS19640 ENOG4105WHD thiamine biosynthesis protein ThiS HO397_RS19645 ENOG4105D06 uba thif-type nad fad binding protein HO397_RS19680 ENOG4105R2J Conserved Protein HO397_RS19690 ENOG4108T8B Protein of unknown function (DUF1481) HO397_RS19695 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HO397_RS19700 ENOG4105BZU Histidine kinase HO397_RS19705 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HO397_RS19710 ENOG4105C12 Phosphoribosylglycinamide synthetase HO397_RS19715 ENOG4105DC1 bifunctional purine biosynthesis protein purh HO397_RS19740 ENOG4105K5X acetyltransferase HO397_RS19745 ENOG4105CVG Homoserine O-transsuccinylase HO397_RS19750 ENOG4107QP3 malate synthase g HO397_RS19755 ENOG4108I9X Isocitrate lyase HO397_RS19760 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HO397_RS19770 ENOG41069M3 Transcriptional regulator HO397_RS19775 ENOG4105C3R Methionine synthase HO397_RS19780 ENOG4105EAM Na Pi-cotransporter HO397_RS19790 ENOG4105FE9 pseudouridine synthase HO397_RS19795 ENOG4108ZR5 Conserved Protein HO397_RS19800 ENOG4105CFH Aspartokinase HO397_RS19805 ENOG4107QP8 phosphohexose isomerase HO397_RS19815 ENOG4108MDC (LipO)protein HO397_RS19820 ENOG4108Q9C Periplasmic Protein HO397_RS19825 ENOG4105E3R (LipO)protein HO397_RS19845 ENOG4107QNK )-transporter HO397_RS19850 ENOG4105EG2 ABC transporter, permease HO397_RS19855 ENOG4105D56 permease protein HO397_RS19860 ENOG4107FKK extracellular solute-binding protein family 1 HO397_RS19865 ENOG4108IJ9 (ABC) transporter HO397_RS19870 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HO397_RS19875 ENOG4107W52 maltose operon periplasmic protein HO397_RS19900 ENOG41080IJ Diacylglycerol kinase HO397_RS19910 ENOG4107R73 Mate efflux family protein HO397_RS19915 ENOG4105VDW Csbd family HO397_RS19920 ENOG4105MYN Zinc uptake regulation protein HO397_RS19930 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HO397_RS19935 ENOG4105P4Z Phage shock protein G HO397_RS19940 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HO397_RS19945 ENOG4105CDU Replicative dna helicase HO397_RS19950 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HO397_RS19955 ENOG4105CGF Aromatic amino acid aminotransferase HO397_RS19965 ENOG4105F0S class B acid phosphatase HO397_RS19970 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HO397_RS19975 ENOG4105MSB protein, conserved in bacteria HO397_RS19980 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HO397_RS19985 ENOG4108UUM single-stranded DNA-binding protein HO397_RS19990 ENOG4105PMV Membrane HO397_RS19995 ENOG4108M8H domain protein HO397_RS20000 ENOG4108W3Q Transcriptional regulator HO397_RS20005 ENOG4108Z4X TRANSCRIPTIONal HO397_RS20010 ENOG4105C7N Xanthine uracil vitamin C permease HO397_RS20015 ENOG4105EEQ Na H antiporter HO397_RS20030 ENOG41062QD Membrane HO397_RS20035 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HO397_RS20045 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HO397_RS20050 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HO397_RS20055 ENOG4105DVI reductase, NrfD HO397_RS20060 ENOG4108QKW cytochrome c-type biogenesis protein HO397_RS20070 ENOG4108W0S formate-dependent nitrite reductase complex HO397_RS20075 ENOG4105CK2 sodium dicarboxylate symporter HO397_RS20080 ENOG41082ND Uncharacterized protein yjcO HO397_RS20090 ENOG4105ETP RND efflux system, outer membrane lipoprotein HO397_RS20095 ENOG4108MI0 Resistance protein HO397_RS20100 ENOG4105J12 Multidrug resistance protein mdtN HO397_RS20105 ENOG4106833 HO397_RS20110 ENOG4105EUZ Beta-lactamase domain protein HO397_RS20115 ENOG4107TFG D-allose kinase HO397_RS20120 ENOG4105UP7 3-epimerase HO397_RS20125 ENOG4105CNN ABC, transporter HO397_RS20130 ENOG4105C2J ABC transporter HO397_RS20135 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HO397_RS20140 ENOG4105NYY transcriptional regulator, RpiR HO397_RS20145 ENOG4108YZG isomerase HO397_RS20155 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HO397_RS20160 ENOG410849A acetyltransferase, (GNAT) family HO397_RS20165 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HO397_RS20170 ENOG4105FD8 phosphonate metabolism protein PhnM HO397_RS20175 ENOG4105HRV phosphonate c-p lyase system protein phnl HO397_RS20180 ENOG4105ENV phosphonate C-P lyase system protein PhnK HO397_RS20185 ENOG4105FT8 Phosphonate metabolism HO397_RS20190 ENOG4105EKV Phosphonate metabolism protein HO397_RS20195 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HO397_RS20200 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HO397_RS20205 ENOG4107RJJ Transcriptional regulator HO397_RS20215 ENOG4105EHI Phosphonate ABC transporter, periplasmic HO397_RS20220 ENOG4105D5T phosphonate abc transporter HO397_RS20225 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HO397_RS20230 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HO397_RS20235 ENOG4108F5E vimentin HO397_RS20240 ENOG4108YIV HO397_RS20245 ENOG4105CSH Transporter HO397_RS20255 ENOG4105ECM Sensor protein basS pmrB HO397_RS20260 ENOG4105XJC Two component transcriptional regulator (Winged helix family HO397_RS20265 ENOG4105DIJ Phosphoethanolamine transferase HO397_RS20270 ENOG4105D5Q Arginine ornithine antiporter HO397_RS20275 ENOG4106ZGR Transcriptional regulator HO397_RS20280 ENOG4105CXN decarboxylase HO397_RS20285 ENOG4108K2B transcriptional regulator HO397_RS20290 ENOG4105F8D glycoside hydrolase family 4 HO397_RS20295 ENOG4105CT4 transporter HO397_RS20300 ENOG4108R5S membrane HO397_RS20305 ENOG4107GFK fumarate HO397_RS20310 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HO397_RS20315 ENOG4108MRH transcriptional regulatory protein HO397_RS20325 ENOG4105VR1 Pfam:DUF1271 HO397_RS20330 ENOG410830R acetyltransferase HO397_RS20345 ENOG4105CRK lysyL-tRNA synthetase HO397_RS20350 ENOG4105DUX Transporter HO397_RS20355 ENOG4105CXN decarboxylase HO397_RS20360 ENOG4105D5Q Arginine ornithine antiporter HO397_RS20365 ENOG4108M3R transcriptional activator CadC HO397_RS20375 ENOG4108SIC Transcriptional regulator HO397_RS20390 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HO397_RS20395 ENOG4108IJ0 Aspartate ammonia-lyase HO397_RS20400 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HO397_RS20405 ENOG4105DVH amino acid HO397_RS20420 ENOG4108ZVF (LipO)protein HO397_RS20425 ENOG4105MTB Uncharacterized protein YjeJ HO397_RS20430 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HO397_RS20440 ENOG4107PEH Entericidin EcnA/B family HO397_RS20445 ENOG4106BSU Entericidin B HO397_RS20450 ENOG4105KPY Small multidrug resistance protein HO397_RS20455 ENOG4105QNF Outer membrane lipoprotein HO397_RS20460 ENOG41066YJ Beta-lactamase HO397_RS20475 ENOG4105E33 succinate dehydrogenase HO397_RS20480 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HO397_RS20490 ENOG4107SC7 Inner membrane transporter yjeM HO397_RS20495 ENOG4105EGS Mechanosensitive ion channel HO397_RS20535 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HO397_RS20540 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HO397_RS20545 ENOG4105K8N protein family UPF0079, ATPase HO397_RS20550 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HO397_RS20555 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HO397_RS20570 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HO397_RS20575 ENOG4107QJR hflk protein HO397_RS20580 ENOG4105EPW hflc protein HO397_RS20600 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HO397_RS20605 ENOG4105C2N RNA methyltransferase TrmH family group 3 HO397_RS20610 ENOG4105FUX Conserved Protein HO397_RS20615 ENOG4108P9J Phage shock protein A HO397_RS20620 ENOG4107VNS Protein of unknown function (DUF2491) HO397_RS20625 ENOG4105Z6B inner membrane protein yjfl HO397_RS20630 ENOG4108KXT Conserved Protein HO397_RS20635 ENOG4106032 Glutathionylspermidine synthase HO397_RS20640 ENOG4105CSU acyl-Coa dehydrogenase HO397_RS20645 ENOG4105S17 UPF0379 protein yjfN HO397_RS20650 ENOG4105WSB biofilm stress and motility protein A HO397_RS20655 ENOG4108MXZ Esterase HO397_RS20670 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HO397_RS20675 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HO397_RS20695 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HO397_RS20700 ENOG4105KIT UPF0379 protein yjfY HO397_RS20715 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HO397_RS20725 ENOG4105DPW Major facilitator superfamily MFS_1 HO397_RS20730 ENOG4107S3R L-aspartate oxidase HO397_RS20735 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HO397_RS20740 ENOG4105E39 Enoyl-CoA hydratase HO397_RS20750 ENOG4105CHR reductase HO397_RS20760 ENOG4105FHY Opacity-associated protein A HO397_RS20765 ENOG4108V1T peptidylprolyl cis-trans isomerase HO397_RS20770 ENOG4105C85 amino acid HO397_RS20780 ENOG4105DXC membrane HO397_RS20785 ENOG4105ECR NmrA family HO397_RS20790 ENOG4105KVH Transcriptional regulator HO397_RS20795 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HO397_RS20800 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HO397_RS20805 ENOG4108UUE Transcriptional regulator HO397_RS20810 ENOG41061GZ Protein of unknown function (DUF1107) HO397_RS20815 ENOG4105C37 (CBS) domain HO397_RS20825 ENOG4105CFU surface antigen HO397_RS20830 ENOG4105MA0 exported protein HO397_RS20835 ENOG4108ZHD aig2 family HO397_RS20840 ENOG4105F0N pyrophosphate phospho-hydrolase HO397_RS20845 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HO397_RS20850 ENOG4105C2J ABC transporter HO397_RS20855 ENOG4107R9N ABC transporter HO397_RS20860 ENOG41062B0 ABC transporter, permease HO397_RS20870 ENOG4105DFU Cell wall formation (By similarity) HO397_RS20880 ENOG4105CMS peptidase U62, modulator of DNA gyrase HO397_RS20890 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HO397_RS20895 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HO397_RS20900 ENOG4105CG3 alpha amylase, catalytic region HO397_RS20905 ENOG4105C5Y PTS System HO397_RS20910 ENOG4105D4X repressor HO397_RS20920 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HO397_RS20925 ENOG4105KME endoribonuclease L-psp HO397_RS20940 ENOG4107C93 pyrBI operon leader peptide HO397_RS20945 ENOG4108UQ8 endoribonuclease L-psp HO397_RS20950 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HO397_RS20955 ENOG4108XFH Transcriptional regulator HO397_RS20960 ENOG4105XEP YhcH YjgK YiaL family protein HO397_RS20975 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HO397_RS20980 ENOG4108MJ3 acetyltransferase HO397_RS20985 ENOG4108M3P Membrane HO397_RS20995 ENOG4105MYG DNA polymerase iii, chi subunit HO397_RS21005 ENOG4108M8S permease YjgP YjgQ family protein HO397_RS21010 ENOG4108K5H permease YjgP YjgQ family protein HO397_RS21015 ENOG4105D7A ATP-binding protein HO397_RS21020 ENOG4105K2J Transcriptional regulator HO397_RS21025 ENOG4105C6Z Gluconate HO397_RS21030 ENOG4105CHR reductase HO397_RS21035 ENOG4105CPQ Dehydrogenase HO397_RS21040 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HO397_RS21045 ENOG4105DQ4 alcohol dehydrogenase HO397_RS21075 ENOG4105VNT transposase (IS4 family) protein HO397_RS21080 ENOG4105JHE Major Facilitator Superfamily HO397_RS21085 ENOG4107RJ5 oxidoreductase HO397_RS21115 ENOG4105C94 Transporter HO397_RS21135 ENOG4105E0A ABC, transporter HO397_RS21140 ENOG4108IHU transport system permease protein HO397_RS21145 ENOG4105DQ5 transport system permease protein HO397_RS21150 ENOG4108HUF Transporter HO397_RS21155 ENOG4105GAV receptor HO397_RS21160 ENOG4108S3W Anti-feci sigma factor, fecr HO397_RS21165 ENOG4108SF5 RNA Polymerase HO397_RS21195 ENOG4108PQ7 sgc region transcriptional regulator HO397_RS21200 ENOG4108RK0 3-epimerase HO397_RS21205 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HO397_RS21210 ENOG4106P19 photosystem i assembly btpa HO397_RS21215 ENOG4105DT3 PTS system, galactitol-specific IIc component HO397_RS21220 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HO397_RS21225 ENOG4105CN9 Peptidase m42 family protein HO397_RS21235 ENOG4105DTA methyltransferase HO397_RS21240 ENOG41080VW acetyltransferase HO397_RS21245 ENOG4105YCT UPF0386 protein HO397_RS21265 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HO397_RS21270 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HO397_RS21290 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HO397_RS21295 ENOG4108RQP Major type 1 subunit fimbrin HO397_RS21300 ENOG4108S54 Fimbrial protein HO397_RS21305 ENOG4108NAE Fimbrial chaperone protein HO397_RS21310 ENOG4105CW0 outer membrane usher protein HO397_RS21315 ENOG4108SQA Fimbrial HO397_RS21320 ENOG4108T65 Fimbrial HO397_RS21325 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HO397_RS21330 ENOG4107EFN gluconate transport system permease 3 HO397_RS21340 ENOG4105DEI Mannitol dehydrogenase HO397_RS21345 ENOG4105C6F GntR Family Transcriptional Regulator HO397_RS21365 ENOG4107YNJ LysR family Transcriptional regulator HO397_RS21370 ENOG4105DYB Isoaspartyl dipeptidase HO397_RS21375 ENOG4108P2H Inner membrane protein YjiG HO397_RS21380 ENOG41074DU domain protein HO397_RS21390 ENOG4105CBP Major Facilitator HO397_RS21395 ENOG4108ZK4 sdia-regulated domain-containing protein HO397_RS21405 ENOG4105CIZ coA-substrate-specific enzyme activase HO397_RS21410 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HO397_RS21415 ENOG4106BRA Membrane HO397_RS21420 ENOG41083G8 Multidrug resistance protein MdtM HO397_RS21440 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC HO397_RS21445 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HO397_RS21470 ENOG4105CVR type I restriction-modification system HO397_RS21475 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HO397_RS21480 ENOG4106H3A restriction HO397_RS21485 ENOG4105CKI cobalamin synthesis protein HO397_RS21490 ENOG4105VCD cytoplasmic protein HO397_RS21495 ENOG4105D22 carbon starvation protein HO397_RS21500 ENOG4107UWN reductase HO397_RS21505 ENOG4105EFA 4-hydroxyphenylacetate HO397_RS21535 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HO397_RS21540 ENOG4105C26 Dehydrogenase HO397_RS21545 ENOG4105ERH Fumarylacetoacetate hydrolase HO397_RS21550 ENOG4108V8F Transcriptional regulator, MarR family HO397_RS21555 ENOG4105C8Q Methyl-accepting chemotaxis HO397_RS21560 ENOG4108I5G Major Facilitator superfamily HO397_RS21570 ENOG4105CPQ Dehydrogenase HO397_RS21580 ENOG4105RI1 glycoprotein receptor HO397_RS21585 ENOG4106CVF DNA replication protein HO397_RS21600 ENOG4105DWK Membrane HO397_RS21605 ENOG4108N8T regulatoR HO397_RS21610 ENOG4108T94 DNA-binding transcriptional activator BglJ HO397_RS21615 ENOG4108819 ferric iron reductase HO397_RS21620 ENOG4105YBH Protein of unknown function (DUF1435) HO397_RS21640 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HO397_RS21645 ENOG4108WPU DNA polymerase III subunit psi HO397_RS21650 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HO397_RS21655 ENOG4105PAD Hydrolase HO397_RS21665 ENOG4105K3G Periplasmic Protein HO397_RS21675 ENOG4108NRW Phospholipase, patatin family HO397_RS21680 ENOG4105EYA deoxyribonuclease HO397_RS21685 ENOG41076CZ activating enzyme HO397_RS21690 ENOG4105G0K glycine radical enzyme YjjI family HO397_RS21710 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HO397_RS21720 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) HO397_RS21725 ENOG41062Z9 Membrane HO397_RS21730 ENOG4105EAC phosphoserine phosphatase HO397_RS21735 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HO397_RS21740 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HO397_RS21745 ENOG4105C5H ABC transporter HO397_RS21750 ENOG4107SC1 transglycosylase HO397_RS21760 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HO397_RS21770 ENOG4105UEI Transcriptional Regulator AraC Family HO397_RS21775 ENOG4108RH0 Crea protein HO397_RS21780 ENOG4105E3W Two component transcriptional regulator (Winged helix family HO397_RS21785 ENOG4105EB3 Histidine kinase HO397_RS21790 ENOG4105CT7 inner membrane cred family protein HO397_RS21795 ENOG41065U4 response regulator HO397_RS21800 ENOG410759A HO397_RS21805 ENOG4106FVC RNA methyltransferase