locus-tag	class	description
B21_RS00010	COG0527	aspartate kinase activity
B21_RS00010	COG0460	homoserine dehydrogenase
B21_RS00020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B21_RS00040	COG1115	amino acid carrier protein
B21_RS00050	COG0521	Mo-molybdopterin cofactor biosynthetic process
B21_RS00055	COG1584	GPR1 FUN34 yaaH family protein
B21_RS00060	COG4735	regulation of single-species biofilm formation
B21_RS00080	COG3385	transposase activity
B21_RS00095	COG0583	DNA-binding transcription factor activity
B21_RS00105	COG3188	usher protein
B21_RS00120	COG1662	PFAM IS1 transposase
B21_RS00140	COG0196	riboflavin kinase activity
B21_RS00155	COG1047	Peptidyl-prolyl cis-trans
B21_RS00185	COG0505	Belongs to the CarA family
B21_RS00190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B21_RS00245	COG0644	oxidoreductase
B21_RS00250	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B21_RS00255	COG2271	Major facilitator Superfamily
B21_RS00270	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B21_RS00295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B21_RS00300	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B21_RS00305	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B21_RS00310	COG0564	pseudouridine synthase activity
B21_RS00320	COG0417	DNA replication proofreading
B21_RS00325	COG0235	Class ii aldolase
B21_RS00340	COG4977	sequence-specific DNA binding
B21_RS00345	COG0586	Pfam SNARE associated Golgi protein
B21_RS00355	COG1178	ABC-type Fe3 transport system permease component
B21_RS00360	COG4143	(ABC) transporter
B21_RS00375	COG2814	Major facilitator Superfamily
B21_RS00390	COG0473	3-isopropylmalate dehydrogenase activity
B21_RS00405	COG0583	DNA-binding transcription factor activity
B21_RS00410	COG0028	Belongs to the TPP enzyme family
B21_RS00415	COG0440	acetolactate synthase activity
B21_RS00425	COG1609	Transcriptional regulator
B21_RS00440	COG3116	cell division
B21_RS00445	COG0768	penicillin binding
B21_RS00450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B21_RS00455	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B21_RS00465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B21_RS00470	COG0772	Belongs to the SEDS family
B21_RS00485	COG1181	Belongs to the D-alanine--D-alanine ligase family
B21_RS00490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B21_RS00495	COG0849	cell division
B21_RS00500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B21_RS00520	COG0494	nUDIX hydrolase
B21_RS00540	COG0237	dephospho-CoA kinase activity
B21_RS00550	COG1459	type II secretion system
B21_RS00555	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B21_RS00560	COG4969	Belongs to the N-Me-Phe pilin family
B21_RS00570	COG0157	Belongs to the NadC ModD family
B21_RS00575	COG3023	N-Acetylmuramoyl-L-alanine amidase
B21_RS00580	COG3725	Membrane protein required for beta-lactamase induction
B21_RS00585	COG1113	amino acid transport
B21_RS00590	COG2186	Transcriptional regulator
B21_RS00595	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B21_RS00600	COG0508	dehydrogenase complex catalyzes the overall conversion of
B21_RS00605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B21_RS00610	COG3064	Membrane
B21_RS00615	COG1049	propionate catabolic process, 2-methylcitrate cycle
B21_RS00640	COG2132	Multicopper oxidase
B21_RS00645	COG4993	Dehydrogenase
B21_RS00650	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B21_RS00655	COG0288	reversible hydration of carbon dioxide
B21_RS00660	COG1131	(ABC) transporter
B21_RS00665	COG0842	Transport permease protein
B21_RS00670	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS00675	COG0726	polysaccharide deacetylase
B21_RS00685	COG5464	transposase or invertase
B21_RS00700	COG3539	Fimbrial protein
B21_RS00705	COG3539	Fimbrial protein
B21_RS00710	COG3539	Fimbrial protein
B21_RS00715	COG3539	Fimbrial protein
B21_RS00720	COG3188	usher protein
B21_RS00725	COG3121	Chaperone
B21_RS00730	COG3539	Fimbrial protein
B21_RS00735	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B21_RS00740	COG0617	tRNA 3'-terminal CCA addition
B21_RS00750	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B21_RS00760	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B21_RS00765	COG1643	Atp-dependent helicase
B21_RS00775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B21_RS00780	COG4774	siderophore transport
B21_RS00785	COG1120	ATPase activity
B21_RS00790	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B21_RS00795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B21_RS00815	COG2860	membrane
B21_RS00820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B21_RS00835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B21_RS00840	COG3835	regulator
B21_RS00850	COG1408	metallophosphoesterase
B21_RS00865	COG0024	Methionine aminopeptidase
B21_RS00890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B21_RS00895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B21_RS00900	COG0575	Belongs to the CDS family
B21_RS00905	COG0750	zinc metalloprotease
B21_RS00915	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
B21_RS00920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B21_RS00945	COG0587	DNA-directed DNA polymerase activity
B21_RS00955	COG1982	Orn Lys Arg decarboxylase major
B21_RS00960	COG0346	lactoylglutathione lyase activity
B21_RS00965	COG0037	tRNA processing
B21_RS00970	COG4568	rho-dependent transcription termination
B21_RS00980	COG4681	YaeQ
B21_RS00985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B21_RS00990	COG3015	lipoprotein NlpE involved in copper resistance
B21_RS00995	COG0791	NLP P60 protein
B21_RS01005	COG1720	tRNA m6t6A37 methyltransferase activity
B21_RS01015	COG1464	Belongs to the NlpA lipoprotein family
B21_RS01020	COG2011	ABC-type metal ion transport system permease component
B21_RS01025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B21_RS01030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B21_RS01065	COG0656	L-ascorbic acid biosynthetic process
B21_RS01070	COG0583	DNA-binding transcription factor activity
B21_RS01080	COG2226	methyltransferase
B21_RS01085	COG1388	LysM domain
B21_RS01085	COG0741	lytic transglycosylase activity
B21_RS01095	COG2226	methyltransferase
B21_RS01105	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B21_RS01125	COG5433	transposase activity
B21_RS01130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B21_RS01140	COG1960	acyl-CoA dehydrogenase activity
B21_RS01150	COG0121	glutamine amidotransferase
B21_RS01155	COG3034	peptidoglycan biosynthetic process
B21_RS01160	COG3041	Addiction module toxin RelE StbE family
B21_RS01165	COG3077	Addiction module antitoxin, RelB DinJ family
B21_RS01170	COG0791	NLP P60 protein
B21_RS01175	COG1943	Transposase
B21_RS01195	COG2161	toxin-antitoxin pair type II binding
B21_RS01205	COG0454	-acetyltransferase
B21_RS01210	COG1690	Belongs to the RtcB family
B21_RS01215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B21_RS01220	COG2195	Cleaves the N-terminal amino acid of tripeptides
B21_RS01245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B21_RS01265	COG0583	DNA-binding transcription factor activity
B21_RS01270	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B21_RS01275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B21_RS01280	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B21_RS01285	COG2080	2 iron, 2 sulfur cluster binding
B21_RS01290	COG3477	response to acidic pH
B21_RS01300	COG0727	PFAM Uncharacterised protein family (UPF0153)
B21_RS01305	COG3121	Chaperone
B21_RS01315	COG3188	usher protein
B21_RS01355	COG1388	LysM domain
B21_RS01360	COG2207	Transcriptional regulator
B21_RS01360	COG3708	Transcriptional regulator
B21_RS01365	COG3059	membrane
B21_RS01375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B21_RS01380	COG2207	Transcriptional regulator
B21_RS01385	COG0247	lactate metabolic process
B21_RS01390	COG1139	Iron-sulfur cluster binding protein
B21_RS01395	COG1556	Lactate utilization protein
B21_RS01425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B21_RS01435	COG2771	luxR family
B21_RS01435	COG2200	EAL domain
B21_RS01440	COG0583	DNA-binding transcription factor activity
B21_RS01450	COG0666	response to abiotic stimulus
B21_RS01460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B21_RS01465	COG1304	FMN binding
B21_RS01475	COG0549	Belongs to the carbamate kinase family
B21_RS01480	COG0402	S-adenosylhomocysteine deaminase activity
B21_RS01485	COG1064	alcohol dehydrogenase
B21_RS01500	COG1280	lysine exporter protein (LysE YggA)
B21_RS01510	COG3829	transcription factor binding
B21_RS01515	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B21_RS01520	COG0372	Belongs to the citrate synthase family
B21_RS01525	COG2079	MmgE PrpD family protein
B21_RS01530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B21_RS01535	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B21_RS01540	COG0402	S-adenosylhomocysteine deaminase activity
B21_RS01545	COG0583	DNA-binding transcription factor activity
B21_RS01550	COG0288	reversible hydration of carbon dioxide
B21_RS01560	COG2807	transmembrane transport
B21_RS01565	COG0110	maltose O-acetyltransferase activity
B21_RS01570	COG2223	nitrite transmembrane transporter activity
B21_RS01575	COG3250	beta-galactosidase activity
B21_RS01580	COG1609	Transcriptional regulator
B21_RS01585	COG1414	Transcriptional regulator
B21_RS01605	COG3971	2-oxopent-4-enoate hydratase activity
B21_RS01620	COG2814	Major facilitator Superfamily
B21_RS01625	COG3122	Protein conserved in bacteria
B21_RS01650	COG1662	PFAM IS1 transposase
B21_RS01655	COG4521	taurine ABC transporter
B21_RS01660	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B21_RS01665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B21_RS01670	COG2175	clavaminate synthase activity
B21_RS01675	COG0113	porphobilinogen synthase activity
B21_RS01680	COG3468	outer membrane autotransporter barrel domain protein
B21_RS01685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B21_RS01690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B21_RS01700	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
B21_RS01720	COG1181	Belongs to the D-alanine--D-alanine ligase family
B21_RS01735	COG1785	Belongs to the alkaline phosphatase family
B21_RS01745	COG3706	GGDEF domain
B21_RS01750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B21_RS01775	COG4126	flavin adenine dinucleotide binding
B21_RS01790	COG1662	PFAM IS1 transposase
B21_RS01800	COG1940	carbohydrate kinase activity
B21_RS01805	COG2814	Major facilitator Superfamily
B21_RS01810	COG0419	ATPase involved in DNA repair
B21_RS01815	COG0420	3'-5' exonuclease activity
B21_RS01820	COG0745	RESPONSE REGULATOR receiver
B21_RS01825	COG5002	protein histidine kinase activity
B21_RS01830	COG1114	Component of the transport system for branched-chain amino acids
B21_RS01835	COG1113	amino acid transport
B21_RS01840	COG0366	Alpha amylase catalytic
B21_RS01860	COG1862	Preprotein translocase
B21_RS01865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B21_RS01870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B21_RS01875	COG1403	HNH endonuclease
B21_RS01885	COG3248	Nucleoside-binding outer membrane protein
B21_RS01890	COG4238	major outer membrane lipoprotein
B21_RS01900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B21_RS01900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B21_RS01915	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B21_RS01920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B21_RS01925	COG0667	Aldo Keto reductase
B21_RS01935	COG0142	geranyltranstransferase activity
B21_RS01950	COG0693	protein deglycase activity
B21_RS01955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B21_RS01965	COG2814	Major facilitator Superfamily
B21_RS01990	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B21_RS01995	COG1845	cytochrome c oxidase, subunit III
B21_RS02000	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B21_RS02005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B21_RS02010	COG2223	nitrite transmembrane transporter activity
B21_RS02015	COG3056	Lipoprotein
B21_RS02020	COG0271	Belongs to the BolA IbaG family
B21_RS02045	COG3385	transposase activity
B21_RS02050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B21_RS02055	COG0776	regulation of translation
B21_RS02060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B21_RS02065	COG1555	photosystem II stabilization
B21_RS02070	COG0824	Thioesterase
B21_RS02080	COG4533	DNA binding
B21_RS02090	COG1522	sequence-specific DNA binding
B21_RS02095	COG1132	(ABC) transporter
B21_RS02100	COG1132	(ABC) transporter
B21_RS02105	COG0347	Belongs to the P(II) protein family
B21_RS02110	COG0004	ammonium transporteR
B21_RS02115	COG1946	Acyl-CoA thioesterase
B21_RS02120	COG3126	Type III secretion system lipoprotein chaperone (YscW)
B21_RS02125	COG3695	enzyme binding
B21_RS02130	COG5507	3-demethylubiquinone-9 3-methyltransferase
B21_RS02135	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B21_RS02145	COG0110	maltose O-acetyltransferase activity
B21_RS02160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B21_RS02165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B21_RS02170	COG1309	transcriptional regulator
B21_RS02175	COG1196	nuclear chromosome segregation
B21_RS02175	COG3264	Mechanosensitive ion channel
B21_RS02190	COG3923	Primosomal replication protein n
B21_RS02195	COG2832	Protein of unknown function (DUF454)
B21_RS02205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B21_RS02240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B21_RS02245	COG4651	solute:proton antiporter activity
B21_RS02245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B21_RS02250	COG2223	nitrite transmembrane transporter activity
B21_RS02255	COG0737	Belongs to the 5'-nucleotidase family
B21_RS02260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B21_RS02265	COG3735	TraB family
B21_RS02270	COG3093	addiction module antidote protein HigA
B21_RS02275	COG2217	Heavy metal translocating P-type atpase
B21_RS02280	COG2066	Belongs to the glutaminase family
B21_RS02285	COG0531	amino acid
B21_RS02290	COG0789	Transcriptional regulator
B21_RS02295	COG1585	Membrane protein implicated in regulation of membrane protease activity
B21_RS02300	COG0330	HflC and HflK could
B21_RS02305	COG4619	ABC transporter
B21_RS02310	COG0390	transport system, permease component
B21_RS02315	COG3118	belongs to the thioredoxin family
B21_RS02320	COG0300	oxidoreductase activity
B21_RS02325	COG2755	lipolytic protein G-D-S-L family
B21_RS02330	COG4181	ATPase activity
B21_RS02335	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B21_RS02340	COG3209	COG3209 Rhs family protein
B21_RS02350	COG3209	COG3209 Rhs family protein
B21_RS02360	COG2801	Transposase and inactivated derivatives
B21_RS02370	COG0583	DNA-binding transcription factor activity
B21_RS02380	COG1414	Transcriptional regulator
B21_RS02385	COG3960	tartronate-semialdehyde synthase activity
B21_RS02390	COG3622	Belongs to the hyi family
B21_RS02395	COG2084	Dehydrogenase
B21_RS02400	COG1953	Uracil, thiamine, allantoin
B21_RS02410	COG2233	PERMEase
B21_RS02415	COG1929	Belongs to the glycerate kinase type-1 family
B21_RS02420	COG3257	ureidoglycine aminohydrolase activity
B21_RS02425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B21_RS02430	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B21_RS02435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B21_RS02440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B21_RS02450	COG0549	Belongs to the carbamate kinase family
B21_RS02455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B21_RS02460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B21_RS02470	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B21_RS02480	COG1988	membrane-bound metal-dependent
B21_RS02485	COG2501	S4 domain
B21_RS02495	COG3539	Fimbrial protein
B21_RS02500	COG3121	Chaperone
B21_RS02505	COG3188	usher protein
B21_RS02510	COG3539	Fimbrial protein
B21_RS02515	COG3539	Fimbrial protein
B21_RS02520	COG2197	response regulator
B21_RS02530	COG0582	viral genome integration into host DNA
B21_RS02565	COG2076	Multidrug Resistance protein
B21_RS02575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B21_RS02580	COG1881	PFAM PEBP family protein
B21_RS02585	COG2207	Transcriptional regulator
B21_RS02625	COG1662	PFAM IS1 transposase
B21_RS02640	COG3772	lysozyme
B21_RS02670	COG4220	transposase activity
B21_RS02680	COG5301	cellulose 1,4-beta-cellobiosidase activity
B21_RS02690	COG5002	protein histidine kinase activity
B21_RS02695	COG0745	RESPONSE REGULATOR receiver
B21_RS02700	COG1538	Outer membrane efflux protein
B21_RS02705	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B21_RS02710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B21_RS02715	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B21_RS02720	COG1113	amino acid transport
B21_RS02725	COG0668	transmembrane transport
B21_RS02730	COG0778	Nitroreductase
B21_RS02735	COG2315	Protein conserved in bacteria
B21_RS02755	COG2963	transposase activity
B21_RS02760	COG2801	Transposase and inactivated derivatives
B21_RS02775	COG3385	transposase activity
B21_RS02780	COG2977	Belongs to the P-Pant transferase superfamily
B21_RS02785	COG4771	TonB-dependent receptor
B21_RS02790	COG2382	esterase
B21_RS02795	COG3251	PFAM MbtH domain protein
B21_RS02800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B21_RS02800	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B21_RS02805	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
B21_RS02810	COG1120	ATPase activity
B21_RS02815	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B21_RS02820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B21_RS02830	COG4592	Periplasmic binding protein
B21_RS02835	COG1169	isochorismate synthase
B21_RS02840	COG1021	2,3-dihydroxybenzoate-AMP ligase
B21_RS02845	COG1535	isochorismatase
B21_RS02845	COG3433	isochorismatase activity
B21_RS02850	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS02855	COG2050	protein possibly involved in aromatic compounds catabolism
B21_RS02865	COG2879	small protein
B21_RS02870	COG0371	Dehydrogenase
B21_RS02875	COG0436	Aminotransferase
B21_RS02880	COG1475	DNA binding
B21_RS02885	COG3969	phosphoadenosine phosphosulfate
B21_RS02890	COG1662	PFAM IS1 transposase
B21_RS02895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B21_RS02900	COG0450	alkyl hydroperoxide reductase
B21_RS02905	COG3634	alkyl hydroperoxide reductase activity
B21_RS02910	COG0589	response to stress
B21_RS02915	COG1063	alcohol dehydrogenase
B21_RS02925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B21_RS02930	COG3719	Belongs to the RNase T2 family
B21_RS02935	COG0471	metal ion transport
B21_RS02950	COG3051	citrate lyase alpha subunit
B21_RS02955	COG2301	Belongs to the HpcH HpaI aldolase family
B21_RS02965	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
B21_RS02970	COG1662	PFAM IS1 transposase
B21_RS02975	COG3290	protein histidine kinase activity
B21_RS02980	COG4565	transcriptional regulatory protein
B21_RS02985	COG3069	C4-dicarboxylate transmembrane transporter activity
B21_RS03005	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B21_RS03010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B21_RS03020	COG0583	DNA-binding transcription factor activity
B21_RS03040	COG1686	Belongs to the peptidase S11 family
B21_RS03045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B21_RS03050	COG0772	Belongs to the SEDS family
B21_RS03055	COG0768	penicillin binding
B21_RS03065	COG0799	negative regulation of ribosome biogenesis
B21_RS03070	COG0406	alpha-ribazole phosphatase activity
B21_RS03080	COG1466	dna polymerase III delta subunit
B21_RS03095	COG2888	peptidyl-tyrosine sulfation
B21_RS03110	COG2214	Heat shock protein DnaJ domain protein
B21_RS03115	COG0443	Heat shock 70 kDa protein
B21_RS03125	COG1126	abc transporter atp-binding protein
B21_RS03130	COG2963	transposase activity
B21_RS03135	COG2801	Transposase and inactivated derivatives
B21_RS03140	COG1126	abc transporter atp-binding protein
B21_RS03145	COG0765	amino acid transport
B21_RS03150	COG0765	amino acid transport
B21_RS03155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B21_RS03165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B21_RS03170	COG4535	Mg2 and Co2 transporter CorC
B21_RS03180	COG1702	phosphate starvation-inducible protein PhoH
B21_RS03190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B21_RS03230	COG0367	asparagine synthase
B21_RS03235	COG0647	UMP catabolic process
B21_RS03240	COG1846	Transcriptional regulator
B21_RS03240	COG1940	carbohydrate kinase activity
B21_RS03245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B21_RS03255	COG2190	(PTS) system
B21_RS03255	COG1263	PTS System
B21_RS03255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B21_RS03275	COG0735	belongs to the Fur family
B21_RS03290	COG0716	FMN binding
B21_RS03300	COG0596	Alpha beta hydrolase
B21_RS03305	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
B21_RS03310	COG0033	Phosphoglucomutase
B21_RS03330	COG0531	amino acid
B21_RS03335	COG1982	Orn Lys Arg decarboxylase major
B21_RS03345	COG0745	RESPONSE REGULATOR receiver
B21_RS03350	COG2205	protein histidine kinase activity
B21_RS03380	COG3209	COG3209 Rhs family protein
B21_RS03385	COG3209	COG3209 Rhs family protein
B21_RS03395	COG3209	COG3209 Rhs family protein
B21_RS03410	COG5433	transposase activity
B21_RS03420	COG5433	transposase activity
B21_RS03425	COG3272	Protein of unknown function (DUF1722)
B21_RS03430	COG0415	Belongs to the DNA photolyase family
B21_RS03440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B21_RS03445	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B21_RS03450	COG1984	allophanate hydrolase subunit 2
B21_RS03465	COG3180	Ammonia monooxygenase
B21_RS03470	COG3539	Fimbrial protein
B21_RS03475	COG3121	Chaperone
B21_RS03480	COG3188	usher protein
B21_RS03485	COG3539	Fimbrial protein
B21_RS03490	COG0372	Belongs to the citrate synthase family
B21_RS03500	COG2009	succinate dehydrogenase
B21_RS03505	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B21_RS03510	COG1053	succinate dehydrogenase
B21_RS03515	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B21_RS03525	COG0567	Dehydrogenase, E1 component
B21_RS03530	COG0508	dehydrogenase complex catalyzes the overall conversion of
B21_RS03540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B21_RS03545	COG2188	Transcriptional regulator
B21_RS03550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS03550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS03550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS03555	COG0383	alpha-mannosidase activity
B21_RS03565	COG1271	oxidase subunit
B21_RS03570	COG1294	oxidase, subunit
B21_RS03575	COG4890	Cyd operon protein YbgT
B21_RS03580	COG3790	cyd operon protein YbgE
B21_RS03585	COG0824	Thioesterase
B21_RS03590	COG0811	peptide transport
B21_RS03595	COG0848	biopolymer transport protein
B21_RS03600	COG3064	Membrane
B21_RS03610	COG2885	chlorophyll binding
B21_RS03615	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B21_RS03660	COG3201	nicotinamide mononucleotide transporter
B21_RS03665	COG1230	cation diffusion facilitator family transporter
B21_RS03680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B21_RS03695	COG4677	pectinesterase activity
B21_RS03700	COG1609	Transcriptional regulator
B21_RS03715	COG0582	viral genome integration into host DNA
B21_RS03830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B21_RS03860	COG5562	phage envelope protein
B21_RS03875	COG4220	transposase activity
B21_RS03895	COG1030	water channel activity
B21_RS03945	COG1196	nuclear chromosome segregation
B21_RS03995	COG1881	PFAM PEBP family protein
B21_RS04000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B21_RS04015	COG2226	methyltransferase
B21_RS04020	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B21_RS04030	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B21_RS04045	COG0521	Mo-molybdopterin cofactor biosynthetic process
B21_RS04055	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B21_RS04060	COG0314	molybdopterin synthase activity
B21_RS04065	COG0670	Belongs to the BI1 family
B21_RS04070	COG0670	Belongs to the BI1 family
B21_RS04075	COG0392	lysyltransferase activity
B21_RS04080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B21_RS04085	COG3568	Endonuclease Exonuclease Phosphatase
B21_RS04095	COG0842	Transport permease protein
B21_RS04100	COG0842	Transport permease protein
B21_RS04105	COG1131	(ABC) transporter
B21_RS04115	COG1309	transcriptional regulator
B21_RS04120	COG0513	Belongs to the DEAD box helicase family
B21_RS04125	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
B21_RS04130	COG1199	ATP-dependent helicase activity
B21_RS04135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B21_RS04140	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B21_RS04150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B21_RS04160	COG4774	siderophore transport
B21_RS04175	COG0668	transmembrane transport
B21_RS04180	COG1126	abc transporter atp-binding protein
B21_RS04185	COG0765	amino acid transport
B21_RS04190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B21_RS04205	COG5006	permease, DMT superfamily
B21_RS04210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B21_RS04215	COG2194	sulfuric ester hydrolase activity
B21_RS04225	COG1321	iron dependent repressor
B21_RS04230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B21_RS04235	COG1376	ErfK ybiS ycfS ynhG family protein
B21_RS04240	COG0488	(ABC) transporter
B21_RS04250	COG0561	phosphatase activity
B21_RS04255	COG1882	Formate acetyltransferase
B21_RS04260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B21_RS04265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B21_RS04270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B21_RS04275	COG0303	'Molybdopterin
B21_RS04280	COG1446	asparaginase
B21_RS04285	COG4172	Belongs to the ABC transporter superfamily
B21_RS04290	COG0747	negative chemotaxis
B21_RS04300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B21_RS04305	COG2200	EAL domain
B21_RS04310	COG2200	EAL domain
B21_RS04315	COG2199	diguanylate cyclase activity
B21_RS04330	COG2133	pyrroloquinoline quinone binding
B21_RS04335	COG0625	glutathione transferase activity
B21_RS04340	COG1686	Belongs to the peptidase S11 family
B21_RS04345	COG1349	DNA-binding transcription factor activity
B21_RS04350	COG0671	phosphoesterase, PA-phosphatase related
B21_RS04355	COG2814	Major facilitator Superfamily
B21_RS04365	COG0561	phosphatase activity
B21_RS04370	COG0738	Major facilitator superfamily
B21_RS04375	COG3226	Transcriptional regulator
B21_RS04385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B21_RS04435	COG4695	Portal protein
B21_RS04505	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B21_RS04515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B21_RS04540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B21_RS04550	COG0778	Nitroreductase
B21_RS04570	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B21_RS04575	COG3842	ATPase activity
B21_RS04580	COG1176	ABC-type spermidine putrescine transport system, permease component I
B21_RS04585	COG1177	transmembrane transport
B21_RS04600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B21_RS04605	COG4160	amino acid transport
B21_RS04610	COG4215	(ABC) transporter
B21_RS04615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B21_RS04620	COG1126	abc transporter atp-binding protein
B21_RS04635	COG3023	N-Acetylmuramoyl-L-alanine amidase
B21_RS04640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B21_RS04645	COG0702	epimerase
B21_RS04650	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B21_RS04655	COG0028	Belongs to the TPP enzyme family
B21_RS04660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B21_RS04670	COG2431	L-lysine efflux transmembrane transporter activity
B21_RS04685	COG3593	DNA synthesis involved in DNA repair
B21_RS04690	COG2990	Protein conserved in bacteria
B21_RS04695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B21_RS04700	COG1136	(ABC) transporter
B21_RS04700	COG0577	efflux transmembrane transporter activity
B21_RS04705	COG1278	Cold shock
B21_RS04715	COG0542	response to heat
B21_RS04735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B21_RS04740	COG4988	ABC transporter
B21_RS04745	COG0492	ferredoxin-NADP+ reductase activity
B21_RS04750	COG1522	sequence-specific DNA binding
B21_RS04755	COG1178	ABC-type Fe3 transport system permease component
B21_RS04755	COG1674	ftsk spoiiie
B21_RS04765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B21_RS04775	COG0243	molybdopterin cofactor binding
B21_RS04780	COG0437	4 iron, 4 sulfur cluster binding
B21_RS04785	COG3302	dmso reductase anchor subunit
B21_RS04790	COG1335	isochorismatase
B21_RS04800	COG0531	amino acid
B21_RS04805	COG0583	DNA-binding transcription factor activity
B21_RS04810	COG2249	NAD(P)H dehydrogenase (quinone) activity
B21_RS04815	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B21_RS04820	COG1882	Formate acetyltransferase
B21_RS04825	COG2116	formate transmembrane transporter activity
B21_RS04830	COG1944	ATP diphosphatase activity
B21_RS04835	COG2323	membrane
B21_RS04850	COG0501	Belongs to the peptidase M48B family
B21_RS04860	COG0539	negative regulation of cytoplasmic translation
B21_RS04870	COG2333	competence protein COMEC
B21_RS04870	COG0658	competence protein
B21_RS04875	COG1132	(ABC) transporter
B21_RS04880	COG1663	tetraacyldisaccharide 4'-kinase activity
B21_RS04885	COG3214	Protein conserved in bacteria
B21_RS04900	COG3173	Aminoglycoside phosphotransferase
B21_RS04905	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B21_RS04910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B21_RS04920	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
B21_RS04930	COG2989	Protein conserved in bacteria
B21_RS04935	COG3108	Peptidase M15
B21_RS04940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B21_RS04945	COG1448	Aminotransferase
B21_RS04970	COG0308	aminopeptidase N
B21_RS04975	COG1116	anion transmembrane transporter activity
B21_RS04980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B21_RS04990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B21_RS04995	COG0431	NADPH-dependent FMN reductase
B21_RS05000	COG3539	Fimbrial protein
B21_RS05005	COG3121	Chaperone
B21_RS05010	COG3188	usher protein
B21_RS05015	COG3539	Fimbrial protein
B21_RS05020	COG3539	Fimbrial protein
B21_RS05025	COG3539	Fimbrial protein
B21_RS05030	COG3121	Chaperone
B21_RS05045	COG0633	Ferredoxin
B21_RS05045	COG3217	Mosc domain protein beta barrel domain protein
B21_RS05055	COG0488	(ABC) transporter
B21_RS05060	COG2995	paraquat-inducible protein a
B21_RS05065	COG3008	intermembrane lipid transfer
B21_RS05065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B21_RS05070	COG3009	Protein conserved in bacteria
B21_RS05075	COG3130	regulation of translation
B21_RS05085	COG1067	ATP-dependent peptidase activity
B21_RS05095	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B21_RS05095	COG2885	chlorophyll binding
B21_RS05110	COG3070	regulator of competence-specific genes
B21_RS05115	COG1289	transmembrane transporter activity
B21_RS05120	COG3304	Inner membrane component domain
B21_RS05125	COG0210	DNA helicase
B21_RS05145	COG1832	CoA-binding protein
B21_RS05160	COG1254	Belongs to the acylphosphatase family
B21_RS05170	COG0670	Belongs to the BI1 family
B21_RS05180	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
B21_RS05185	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B21_RS05190	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
B21_RS05195	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B21_RS05200	COG1999	signal sequence binding
B21_RS05205	COG1773	rubredoxin
B21_RS05210	COG1271	oxidase subunit
B21_RS05215	COG1294	oxidase, subunit
B21_RS05230	COG3206	protein involved in exopolysaccharide biosynthesis
B21_RS05230	COG0489	protein tyrosine kinase activity
B21_RS05235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B21_RS05240	COG1596	polysaccharide export
B21_RS05245	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B21_RS05265	COG1278	Cold shock
B21_RS05270	COG1278	Cold shock
B21_RS05285	COG0348	domain, Protein
B21_RS05290	COG2198	Histidine kinase
B21_RS05290	COG0784	Response regulator, receiver
B21_RS05290	COG2205	protein histidine kinase activity
B21_RS05295	COG1879	ABC-type sugar transport system periplasmic component
B21_RS05300	COG0745	RESPONSE REGULATOR receiver
B21_RS05305	COG3005	denitrification pathway
B21_RS05310	COG0243	molybdopterin cofactor binding
B21_RS05355	COG3729	General stress protein
B21_RS05360	COG2233	PERMEase
B21_RS05385	COG1335	isochorismatase
B21_RS05395	COG1309	transcriptional regulator
B21_RS05400	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B21_RS05400	COG0506	proline dehydrogenase activity
B21_RS05400	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B21_RS05410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B21_RS05425	COG2822	iron ion transport
B21_RS05430	COG2837	iron assimilation
B21_RS05440	COG1702	phosphate starvation-inducible protein PhoH
B21_RS05445	COG3658	cytochrome
B21_RS05450	COG1215	transferase activity, transferring glycosyl groups
B21_RS05455	COG1649	PFAM Uncharacterised BCR, COG1649
B21_RS05455	COG0726	polysaccharide deacetylase
B21_RS05460	COG0457	Tetratricopeptide repeat
B21_RS05465	COG3706	GGDEF domain
B21_RS05470	COG2801	Transposase and inactivated derivatives
B21_RS05500	COG3381	protein complex oligomerization
B21_RS05510	COG1462	curli production assembly transport component CsgG
B21_RS05525	COG2197	response regulator
B21_RS05555	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B21_RS05560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B21_RS05585	COG2943	transferase activity, transferring hexosyl groups
B21_RS05590	COG5645	(Lipo)protein
B21_RS05610	COG1560	Kdo2-lipid A biosynthetic process
B21_RS05620	COG2353	YceI-like domain
B21_RS05625	COG3038	cytochrome b561
B21_RS05660	COG2999	glutathione oxidoreductase activity
B21_RS05670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B21_RS05680	COG0673	inositol 2-dehydrogenase activity
B21_RS05685	COG0728	peptidoglycan biosynthetic process
B21_RS05690	COG3418	PFAM FlgN family protein
B21_RS05695	COG2747	anti-sigma28 factor FlgM
B21_RS05700	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
B21_RS05705	COG1815	bacterial-type flagellum-dependent cell motility
B21_RS05710	COG1558	bacterial-type flagellum-dependent cell motility
B21_RS05715	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B21_RS05720	COG1749	Flagellar hook protein flgE
B21_RS05725	COG4787	bacterial-type flagellum-dependent cell motility
B21_RS05730	COG4786	Flagellar basal body rod
B21_RS05745	COG1705	Flagellar rod assembly protein muramidase FlgJ
B21_RS05745	COG3951	Flagellar rod assembly protein muramidase FlgJ
B21_RS05750	COG1256	bacterial-type flagellum assembly
B21_RS05755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B21_RS05760	COG1530	ribonuclease E activity
B21_RS05770	COG0564	pseudouridine synthase activity
B21_RS05775	COG0424	maF-like protein
B21_RS05780	COG1399	metal-binding, possibly nucleic acid-binding protein
B21_RS05800	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B21_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS05815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B21_RS05820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B21_RS05825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B21_RS05835	COG0470	DNA polymerase III
B21_RS05840	COG0084	hydrolase, TatD family'
B21_RS05845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B21_RS05845	COG1263	PTS System
B21_RS05850	COG4773	Receptor
B21_RS05855	COG0537	adenosine 5'-monophosphoramidase activity
B21_RS05860	COG5633	Lipoprotein
B21_RS05865	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
B21_RS05885	COG1252	NADH dehydrogenase
B21_RS05890	COG3134	Outer membrane lipoprotein
B21_RS05895	COG1309	transcriptional regulator
B21_RS05905	COG1376	ErfK ybiS ycfS ynhG family protein
B21_RS05905	COG1388	LysM domain
B21_RS05910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B21_RS05915	COG4763	Acyl-transferase
B21_RS05920	COG4591	ABC-type transport system involved in lipoprotein release permease component
B21_RS05930	COG4591	ABC-type transport system involved in lipoprotein release permease component
B21_RS05950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B21_RS05955	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B21_RS05965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B21_RS05970	COG1177	transmembrane transport
B21_RS05995	COG2850	peptidyl-arginine hydroxylation
B21_RS06000	COG2205	protein histidine kinase activity
B21_RS06010	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B21_RS06030	COG1187	pseudouridine synthase activity
B21_RS06035	COG0538	isocitrate dehydrogenase activity
B21_RS06050	COG5562	phage envelope protein
B21_RS06055	COG0789	Transcriptional regulator
B21_RS06060	COG2200	EAL domain
B21_RS06085	COG2200	EAL domain
B21_RS06135	COG2894	cell division
B21_RS06165	COG0179	Fumarylacetoacetate (FAA) hydrolase
B21_RS06185	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B21_RS06190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B21_RS06195	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B21_RS06210	COG2719	SpoVR family
B21_RS06220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B21_RS06230	COG1619	proteins homologs of microcin C7 resistance protein MccF
B21_RS06240	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B21_RS06260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B21_RS06260	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
B21_RS06260	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS06265	COG1461	Dihydroxyacetone kinase
B21_RS06270	COG2376	Dihydroxyacetone kinase
B21_RS06275	COG3284	Transcriptional regulator
B21_RS06280	COG3468	outer membrane autotransporter barrel domain protein
B21_RS06290	COG0012	GTP binding
B21_RS06305	COG0659	secondary active sulfate transmembrane transporter activity
B21_RS06310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B21_RS06335	COG2890	protein-(glutamine-N5) methyltransferase activity
B21_RS06340	COG3094	Invasion gene expression up-regulator, SirB
B21_RS06345	COG2912	Transglutaminase-like superfamily
B21_RS06370	COG0387	Pfam Sodium calcium exchanger
B21_RS06375	COG4572	Cation transport regulator
B21_RS06380	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B21_RS06385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B21_RS06390	COG4932	domain protein
B21_RS06395	COG2197	response regulator
B21_RS06400	COG3850	Histidine kinase
B21_RS06410	COG2223	nitrite transmembrane transporter activity
B21_RS06415	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B21_RS06420	COG1140	nitrate reductase beta subunit
B21_RS06425	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B21_RS06430	COG2181	nitrate reductase activity
B21_RS06445	COG0788	formyltetrahydrofolate deformylase activity
B21_RS06455	COG1752	Esterase of the alpha-beta hydrolase superfamily
B21_RS06460	COG0745	RESPONSE REGULATOR receiver
B21_RS06465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B21_RS06475	COG1435	thymidine kinase activity
B21_RS06480	COG1454	alcohol dehydrogenase
B21_RS06480	COG1012	belongs to the aldehyde dehydrogenase family
B21_RS06485	COG2095	MarC family integral membrane protein
B21_RS06490	COG4166	transmembrane transport
B21_RS06495	COG0601	transmembrane transport
B21_RS06500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B21_RS06505	COG0444	Belongs to the ABC transporter superfamily
B21_RS06510	COG4608	Belongs to the ABC transporter superfamily
B21_RS06530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B21_RS06535	COG2350	Protein conserved in bacteria
B21_RS06540	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B21_RS06545	COG1607	acyl-coa hydrolase
B21_RS06560	COG3047	cAMP biosynthetic process
B21_RS06565	COG3685	Protein conserved in bacteria
B21_RS06570	COG3685	Protein conserved in bacteria
B21_RS06575	COG3729	General stress protein
B21_RS06590	COG0134	indole-3-glycerol-phosphate synthase activity
B21_RS06590	COG0135	phosphoribosylanthranilate isomerase activity
B21_RS06595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B21_RS06595	COG0512	Glutamine amidotransferase of anthranilate synthase
B21_RS06600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B21_RS06605	COG0613	PHP domain protein
B21_RS06610	COG0009	L-threonylcarbamoyladenylate synthase
B21_RS06615	COG4907	membrane protein (DUF2207)
B21_RS06620	COG1662	PFAM IS1 transposase
B21_RS06625	COG4907	membrane protein (DUF2207)
B21_RS06630	COG1187	pseudouridine synthase activity
B21_RS06635	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B21_RS06640	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS06650	COG0616	signal peptide processing
B21_RS06665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B21_RS06670	COG0583	DNA-binding transcription factor activity
B21_RS06695	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B21_RS06705	COG0671	phosphoesterase, PA-phosphatase related
B21_RS06710	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
B21_RS06715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B21_RS06725	COG0023	Translation Initiation Factor
B21_RS06735	COG1349	DNA-binding transcription factor activity
B21_RS06745	COG5001	Diguanylate cyclase
B21_RS06760	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B21_RS06760	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B21_RS06765	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B21_RS06775	COG2852	Protein conserved in bacteria
B21_RS06780	COG4172	Belongs to the ABC transporter superfamily
B21_RS06785	COG4172	Belongs to the ABC transporter superfamily
B21_RS06790	COG4171	peptide transport system, permease
B21_RS06795	COG4168	peptide transport system, permease
B21_RS06800	COG4166	transmembrane transport
B21_RS06815	COG0531	amino acid
B21_RS06820	COG0174	glutamine synthetase
B21_RS06825	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B21_RS06830	COG1917	Cupin 2, conserved barrel domain protein
B21_RS06830	COG1396	sequence-specific DNA binding
B21_RS06835	COG1012	belongs to the aldehyde dehydrogenase family
B21_RS06840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B21_RS06845	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B21_RS06850	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B21_RS06855	COG1842	Phage shock protein A
B21_RS06865	COG1983	PspC domain protein
B21_RS06875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B21_RS06880	COG0366	Alpha amylase catalytic
B21_RS06885	COG1653	transport
B21_RS06890	COG1175	transmembrane transport
B21_RS06895	COG0395	ABC-type sugar transport system, permease component
B21_RS06900	COG1063	alcohol dehydrogenase
B21_RS06905	COG1082	Xylose isomerase domain protein TIM barrel
B21_RS06910	COG0673	inositol 2-dehydrogenase activity
B21_RS06915	COG1554	hydrolase, family 65, central catalytic
B21_RS06920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B21_RS06925	COG3842	ATPase activity
B21_RS06935	COG1609	Transcriptional regulator
B21_RS06940	COG3106	COG3106 Predicted ATPase
B21_RS06950	COG3283	Transcriptional regulator of aromatic amino acids metabolism
B21_RS06955	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B21_RS06960	COG4948	Mandelate Racemase Muconate Lactonizing
B21_RS06965	COG2866	Carboxypeptidase
B21_RS06970	COG0702	epimerase
B21_RS06975	COG1073	alpha beta
B21_RS06980	COG0583	DNA-binding transcription factor activity
B21_RS06990	COG4166	transmembrane transport
B21_RS06995	COG0668	transmembrane transport
B21_RS07000	COG3182	Iron-regulated membrane protein
B21_RS07005	COG0589	response to stress
B21_RS07015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B21_RS07020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B21_RS07030	COG1473	amidohydrolase
B21_RS07035	COG1473	amidohydrolase
B21_RS07040	COG0583	DNA-binding transcription factor activity
B21_RS07050	COG2840	Smr protein MutS2
B21_RS07055	COG3706	GGDEF domain
B21_RS07070	COG0513	Belongs to the DEAD box helicase family
B21_RS07080	COG0582	viral genome integration into host DNA
B21_RS07100	COG3723	Recombinational DNA repair protein, rece pathway
B21_RS07145	COG3772	lysozyme
B21_RS07155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B21_RS07160	COG1475	DNA binding
B21_RS07180	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
B21_RS07185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B21_RS07195	COG0589	response to stress
B21_RS07200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B21_RS07205	COG1013	pyruvate-flavodoxin oxidoreductase activity
B21_RS07205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B21_RS07205	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B21_RS07205	COG0674	pyruvate-flavodoxin oxidoreductase activity
B21_RS07210	COG3042	response to heat
B21_RS07215	COG3187	Heat shock protein
B21_RS07220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B21_RS07225	COG2911	Protein conserved in bacteria
B21_RS07235	COG3784	Protein of unknown function (DUF1318)
B21_RS07240	COG2207	Transcriptional regulator
B21_RS07245	COG1012	belongs to the aldehyde dehydrogenase family
B21_RS07250	COG3733	amine oxidase
B21_RS07260	COG2801	Transposase and inactivated derivatives
B21_RS07265	COG0667	Aldo Keto reductase
B21_RS07275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B21_RS07280	COG4589	Belongs to the CDS family
B21_RS07285	COG2267	carboxylic ester hydrolase activity
B21_RS07290	COG2453	phosphatase
B21_RS07290	COG0671	phosphoesterase, PA-phosphatase related
B21_RS07300	COG1643	Atp-dependent helicase
B21_RS07305	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B21_RS07310	COG1012	belongs to the aldehyde dehydrogenase family
B21_RS07315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B21_RS07325	COG1662	PFAM IS1 transposase
B21_RS07330	COG3038	cytochrome b561
B21_RS07345	COG0840	transmembrane signaling receptor activity
B21_RS07350	COG0583	DNA-binding transcription factor activity
B21_RS07355	COG5383	Protein conserved in bacteria
B21_RS07370	COG2841	Protein conserved in bacteria
B21_RS07375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B21_RS07380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B21_RS07385	COG1275	C4-dicarboxylate transporter malic acid transport protein
B21_RS07390	COG0500	methyltransferase
B21_RS07410	COG0675	Transposase, IS605 OrfB family
B21_RS07415	COG3135	benzoate transporter
B21_RS07420	COG1396	sequence-specific DNA binding
B21_RS07425	COG0826	peptidase U32
B21_RS07435	COG1724	mRNA binding
B21_RS07440	COG1598	PFAM Uncharacterised protein family UPF0150
B21_RS07445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B21_RS07450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B21_RS07455	COG3842	ATPase activity
B21_RS07460	COG1176	ABC-type spermidine putrescine transport system, permease component I
B21_RS07465	COG1177	transmembrane transport
B21_RS07490	COG3238	Protein conserved in bacteria
B21_RS07495	COG1247	-acetyltransferase
B21_RS07500	COG2130	NADP-dependent
B21_RS07505	COG1802	Transcriptional regulator
B21_RS07510	COG4772	TonB-dependent receptor
B21_RS07515	COG3391	amine dehydrogenase activity
B21_RS07520	COG1113	amino acid transport
B21_RS07525	COG0625	glutathione transferase activity
B21_RS07540	COG3209	COG3209 Rhs family protein
B21_RS07550	COG5433	transposase activity
B21_RS07555	COG5433	transposase activity
B21_RS07565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B21_RS07570	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B21_RS07580	COG2181	nitrate reductase activity
B21_RS07585	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B21_RS07590	COG1140	nitrate reductase beta subunit
B21_RS07595	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B21_RS07600	COG2223	nitrite transmembrane transporter activity
B21_RS07610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B21_RS07615	COG0697	spore germination
B21_RS07620	COG3383	formate dehydrogenase (NAD+) activity
B21_RS07620	COG0243	molybdopterin cofactor binding
B21_RS07625	COG0243	molybdopterin cofactor binding
B21_RS07625	COG3383	formate dehydrogenase (NAD+) activity
B21_RS07630	COG0437	4 iron, 4 sulfur cluster binding
B21_RS07635	COG2864	formate dehydrogenase
B21_RS07640	COG3093	addiction module antidote protein HigA
B21_RS07645	COG1064	alcohol dehydrogenase
B21_RS07665	COG1764	response to oxidative stress
B21_RS07670	COG4608	Belongs to the ABC transporter superfamily
B21_RS07675	COG0444	Belongs to the ABC transporter superfamily
B21_RS07680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B21_RS07685	COG0601	transmembrane transport
B21_RS07690	COG0747	negative chemotaxis
B21_RS07695	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
B21_RS07700	COG2202	Pas domain
B21_RS07700	COG2200	EAL domain
B21_RS07700	COG2199	diguanylate cyclase activity
B21_RS07710	COG1649	PFAM Uncharacterised BCR, COG1649
B21_RS07715	COG0531	amino acid
B21_RS07720	COG0076	glutamate decarboxylase activity
B21_RS07730	COG0612	Peptidase, M16
B21_RS07735	COG4771	TonB-dependent receptor
B21_RS07740	COG4178	(ABC) transporter
B21_RS07745	COG0641	radical SAM
B21_RS07750	COG3119	arylsulfatase activity
B21_RS07755	COG2207	Transcriptional regulator
B21_RS07765	COG0243	molybdopterin cofactor binding
B21_RS07770	COG3539	Fimbrial protein
B21_RS07775	COG3539	Fimbrial protein
B21_RS07780	COG3539	Fimbrial protein
B21_RS07785	COG3188	usher protein
B21_RS07790	COG3188	usher protein
B21_RS07805	COG3539	Fimbrial protein
B21_RS07810	COG3550	peptidyl-serine autophosphorylation
B21_RS07815	COG1396	sequence-specific DNA binding
B21_RS07850	COG3781	membrane
B21_RS07860	COG2199	diguanylate cyclase activity
B21_RS07870	COG2066	Belongs to the glutaminase family
B21_RS07875	COG1012	belongs to the aldehyde dehydrogenase family
B21_RS07880	COG0583	DNA-binding transcription factor activity
B21_RS07910	COG1846	Transcriptional regulator
B21_RS07915	COG4977	sequence-specific DNA binding
B21_RS07925	COG0697	spore germination
B21_RS07930	COG2814	Major facilitator Superfamily
B21_RS07940	COG3706	GGDEF domain
B21_RS07945	COG3111	PFAM Bacterial OB fold (BOF) protein
B21_RS07950	COG1546	Belongs to the CinA family
B21_RS07955	COG0339	signal peptide processing
B21_RS07960	COG4221	oxidoreductase activity
B21_RS07965	COG1802	Transcriptional regulator
B21_RS07975	COG0246	Mannitol dehydrogenase
B21_RS07980	COG0477	Major facilitator Superfamily
B21_RS07995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B21_RS08025	COG2801	Transposase and inactivated derivatives
B21_RS08040	COG1403	HNH endonuclease
B21_RS08040	COG1403	HNH endonuclease
B21_RS08070	COG1846	Transcriptional regulator
B21_RS08085	COG1396	sequence-specific DNA binding
B21_RS08115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B21_RS08135	COG1063	alcohol dehydrogenase
B21_RS08140	COG4948	Mandelate Racemase Muconate Lactonizing
B21_RS08155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B21_RS08170	COG0243	molybdopterin cofactor binding
B21_RS08175	COG0243	molybdopterin cofactor binding
B21_RS08180	COG0437	4 iron, 4 sulfur cluster binding
B21_RS08185	COG3302	dmso reductase anchor subunit
B21_RS08190	COG3381	protein complex oligomerization
B21_RS08200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B21_RS08205	COG1940	carbohydrate kinase activity
B21_RS08210	COG0583	DNA-binding transcription factor activity
B21_RS08215	COG2814	Major facilitator Superfamily
B21_RS08230	COG3591	Belongs to the peptidase S1B family
B21_RS08245	COG0628	permease
B21_RS08250	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B21_RS08255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B21_RS08265	COG0531	amino acid
B21_RS08275	COG3136	membrane protein required for alginate biosynthesis
B21_RS08280	COG0745	RESPONSE REGULATOR receiver
B21_RS08285	COG2205	protein histidine kinase activity
B21_RS08295	COG0114	fumarate hydratase activity
B21_RS08300	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B21_RS08300	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B21_RS08305	COG1482	cell wall glycoprotein biosynthetic process
B21_RS08310	COG5339	Protein conserved in bacteria
B21_RS08325	COG3250	beta-galactosidase activity
B21_RS08330	COG1309	transcriptional regulator
B21_RS08335	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS08340	COG1609	Transcriptional regulator
B21_RS08345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B21_RS08345	COG1263	PTS System
B21_RS08350	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B21_RS08360	COG0673	inositol 2-dehydrogenase activity
B21_RS08400	COG4659	FMN binding
B21_RS08410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B21_RS08420	COG3104	oligopeptide transport
B21_RS08425	COG0625	glutathione transferase activity
B21_RS08430	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B21_RS08445	COG3895	Periplasmic Protein
B21_RS08455	COG3133	Outer membrane lipoprotein
B21_RS08470	COG1566	PFAM secretion protein HlyD family protein
B21_RS08475	COG1289	transmembrane transporter activity
B21_RS08480	COG2032	superoxide dismutase activity
B21_RS08485	COG4989	oxidoreductase activity
B21_RS08490	COG3313	Fe-S protein
B21_RS08495	COG1309	transcriptional regulator
B21_RS08500	COG1902	pentaerythritol trinitrate reductase activity
B21_RS08505	COG0346	lactoylglutathione lyase activity
B21_RS08515	COG1201	RNA secondary structure unwinding
B21_RS08520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B21_RS08525	COG0791	NLP P60 protein
B21_RS08530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B21_RS08535	COG2814	Major facilitator Superfamily
B21_RS08550	COG0583	DNA-binding transcription factor activity
B21_RS08555	COG2814	Major facilitator Superfamily
B21_RS08560	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B21_RS08565	COG0307	riboflavin synthase, alpha
B21_RS08575	COG3468	outer membrane autotransporter barrel domain protein
B21_RS08595	COG4529	Protein conserved in bacteria
B21_RS08605	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
B21_RS08610	COG0437	4 iron, 4 sulfur cluster binding
B21_RS08620	COG2414	aldehyde ferredoxin oxidoreductase
B21_RS08625	COG0437	4 iron, 4 sulfur cluster binding
B21_RS08635	COG0469	pyruvate kinase activity
B21_RS08640	COG4238	major outer membrane lipoprotein
B21_RS08645	COG1376	ErfK ybiS ycfS ynhG family protein
B21_RS08660	COG0719	Fe-S assembly protein
B21_RS08665	COG0396	ATPase activity
B21_RS08670	COG0719	Fe-S assembly protein
B21_RS08675	COG0316	Belongs to the HesB IscA family
B21_RS08685	COG2050	protein possibly involved in aromatic compounds catabolism
B21_RS08690	COG0277	FAD linked oxidase domain protein
B21_RS08690	COG0247	lactate metabolic process
B21_RS08695	COG0628	permease
B21_RS08710	COG2271	Major facilitator Superfamily
B21_RS08725	COG4670	ketone body catabolic process
B21_RS08730	COG1960	acyl-CoA dehydrogenase activity
B21_RS08735	COG1917	Cupin 2, conserved barrel domain protein
B21_RS08735	COG2207	Transcriptional regulator
B21_RS08745	COG2086	electron transfer activity
B21_RS08750	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B21_RS08755	COG0644	oxidoreductase
B21_RS08760	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B21_RS08765	COG0318	PFAM AMP-dependent synthetase and ligase
B21_RS08770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B21_RS08770	COG0574	Belongs to the PEP-utilizing enzyme family
B21_RS08785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B21_RS08790	COG4256	Hemin uptake protein
B21_RS08805	COG0791	NLP P60 protein
B21_RS08815	COG0386	Belongs to the glutathione peroxidase family
B21_RS08830	COG0072	phenylalanine-tRNA ligase activity
B21_RS08830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B21_RS08875	COG3137	Salt-induced outer membrane protein
B21_RS08880	COG1105	Belongs to the carbohydrate kinase PfkB family
B21_RS08890	COG3001	Fructosamine kinase
B21_RS08900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B21_RS08905	COG1988	membrane-bound metal-dependent
B21_RS08910	COG1823	symporter activity
B21_RS08925	COG0753	catalase activity
B21_RS08935	COG1486	melibiose metabolic process
B21_RS08940	COG1917	Cupin 2, conserved barrel domain protein
B21_RS08940	COG2169	Transcriptional regulator
B21_RS08945	COG1447	Phosphotransferase system cellobiose-specific component IIA
B21_RS08950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B21_RS08955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B21_RS08960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B21_RS08975	COG0322	excinuclease ABC activity
B21_RS08985	COG3678	ATP-independent chaperone mediated protein folding
B21_RS09015	COG0708	Exodeoxyribonuclease III
B21_RS09020	COG0398	Pfam SNARE associated Golgi protein
B21_RS09030	COG0398	Pfam SNARE associated Golgi protein
B21_RS09035	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B21_RS09040	COG4134	Bacterial extracellular solute-binding protein
B21_RS09045	COG4135	transport system, permease component
B21_RS09050	COG4136	ATPase activity
B21_RS09055	COG2897	thiosulfate sulfurtransferase activity
B21_RS09060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B21_RS09065	COG0494	nUDIX hydrolase
B21_RS09075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B21_RS09085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B21_RS09100	COG0778	Nitroreductase
B21_RS09110	COG0616	signal peptide processing
B21_RS09115	COG0252	asparaginase activity
B21_RS09120	COG1335	isochorismatase
B21_RS09125	COG2814	Major facilitator Superfamily
B21_RS09130	COG1349	DNA-binding transcription factor activity
B21_RS09135	COG0667	Aldo Keto reductase
B21_RS09140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B21_RS09145	COG0191	fructose-bisphosphate aldolase activity
B21_RS09150	COG1063	alcohol dehydrogenase
B21_RS09155	COG2271	Major facilitator Superfamily
B21_RS09160	COG1063	alcohol dehydrogenase
B21_RS09165	COG3139	Protein of unknown function (DUF1315)
B21_RS09175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B21_RS09180	COG0676	glucose-6-phosphate 1-epimerase activity
B21_RS09185	COG0656	L-ascorbic acid biosynthetic process
B21_RS09190	COG3713	MltA-interacting MipA family protein
B21_RS09195	COG2766	serine protein kinase
B21_RS09205	COG2199	diguanylate cyclase activity
B21_RS09210	COG2199	diguanylate cyclase activity
B21_RS09215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B21_RS09230	COG2207	Transcriptional regulator
B21_RS09235	COG2807	transmembrane transport
B21_RS09240	COG3189	MarR family transcriptional regulator
B21_RS09245	COG3042	response to heat
B21_RS09250	COG2199	diguanylate cyclase activity
B21_RS09250	COG2203	Gaf domain
B21_RS09260	COG2261	transglycosylase associated protein
B21_RS09270	COG3615	Tellurite resistance protein tehB
B21_RS09275	COG3385	transposase activity
B21_RS09280	COG3615	Tellurite resistance protein tehB
B21_RS09290	COG0583	DNA-binding transcription factor activity
B21_RS09295	COG0473	3-isopropylmalate dehydrogenase activity
B21_RS09300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B21_RS09305	COG4638	Rieske (2fe-2S)
B21_RS09310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B21_RS09315	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B21_RS09320	COG0318	PFAM AMP-dependent synthetase and ligase
B21_RS09325	COG3065	identical protein binding
B21_RS09330	COG1214	PFAM Peptidase M22, glycoprotease
B21_RS09335	COG1199	ATP-dependent helicase activity
B21_RS09340	COG0251	oxidation-reduction process
B21_RS09360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B21_RS09370	COG1760	l-serine dehydratase
B21_RS09375	COG2200	EAL domain
B21_RS09380	COG1253	flavin adenine dinucleotide binding
B21_RS09390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B21_RS09390	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS09395	COG3715	PTS system
B21_RS09400	COG3716	PTS system mannose fructose sorbose family IID component
B21_RS09420	COG2226	methyltransferase
B21_RS09455	COG1414	Transcriptional regulator
B21_RS09460	COG2814	Major facilitator Superfamily
B21_RS09470	COG0793	Belongs to the peptidase S41A family
B21_RS09480	COG1956	GAF domain-containing protein
B21_RS09485	COG2995	paraquat-inducible protein a
B21_RS09490	COG3008	intermembrane lipid transfer
B21_RS09510	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B21_RS09525	COG1276	copper resistance
B21_RS09530	COG2372	response to copper ion
B21_RS09540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B21_RS09545	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B21_RS09550	COG1770	oligopeptidase
B21_RS09555	COG2979	Protein of unknown function (DUF533)
B21_RS09570	COG3141	response to X-ray
B21_RS09580	COG0800	Aldolase
B21_RS09585	COG0129	dihydroxy-acid dehydratase activity
B21_RS09590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B21_RS09600	COG1737	Transcriptional regulator
B21_RS09605	COG0469	pyruvate kinase activity
B21_RS09610	COG1560	Kdo2-lipid A biosynthetic process
B21_RS09615	COG0739	heme binding
B21_RS09620	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B21_RS09630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B21_RS09655	COG0217	transcriptional regulatory protein
B21_RS09660	COG0494	nUDIX hydrolase
B21_RS09670	COG1335	isochorismatase
B21_RS09675	COG1801	Protein of unknown function DUF72
B21_RS09680	COG3788	relative of glutathione S-transferase, MAPEG superfamily
B21_RS09695	COG0243	molybdopterin cofactor binding
B21_RS09700	COG3005	denitrification pathway
B21_RS09710	COG3102	Protein conserved in bacteria
B21_RS09720	COG3755	Protein conserved in bacteria
B21_RS09730	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B21_RS09735	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B21_RS09740	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B21_RS09745	COG0745	RESPONSE REGULATOR receiver
B21_RS09755	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B21_RS09760	COG0840	transmembrane signaling receptor activity
B21_RS09765	COG0840	transmembrane signaling receptor activity
B21_RS09770	COG0835	chemotaxis
B21_RS09775	COG2198	Histidine kinase
B21_RS09775	COG0643	Histidine kinase
B21_RS09780	COG1360	Flagellar Motor Protein
B21_RS09785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B21_RS09800	COG0589	response to stress
B21_RS09810	COG1877	trehalose-phosphatase activity
B21_RS09815	COG1172	Belongs to the binding-protein-dependent transport system permease family
B21_RS09820	COG1129	ABC transporter
B21_RS09825	COG1879	ABC-type sugar transport system periplasmic component
B21_RS09830	COG1528	Iron-storage protein
B21_RS09850	COG1528	Iron-storage protein
B21_RS09860	COG0814	amino acid
B21_RS09865	COG3012	SEC-C Motif Domain Protein
B21_RS09865	COG3318	Belongs to the UPF0149 family
B21_RS09895	COG2197	response regulator
B21_RS09900	COG1662	PFAM IS1 transposase
B21_RS09910	COG2205	protein histidine kinase activity
B21_RS09915	COG0745	RESPONSE REGULATOR receiver
B21_RS09920	COG2351	hydroxyisourate hydrolase activity
B21_RS09935	COG3443	Belongs to the bacterial solute-binding protein 9 family
B21_RS09940	COG3038	cytochrome b561
B21_RS09965	COG1388	LysM domain
B21_RS09965	COG1470	cell adhesion involved in biofilm formation
B21_RS09975	COG0477	Major facilitator Superfamily
B21_RS09980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B21_RS09985	COG0217	transcriptional regulatory protein
B21_RS09995	COG0534	Mate efflux family protein
B21_RS10005	COG0583	DNA-binding transcription factor activity
B21_RS10010	COG0583	DNA-binding transcription factor activity
B21_RS10020	COG1376	ErfK ybiS ycfS ynhG family protein
B21_RS10035	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
B21_RS10075	COG4372	Transposase
B21_RS10090	COG1289	transmembrane transporter activity
B21_RS10100	COG1686	Belongs to the peptidase S11 family
B21_RS10105	COG2925	Exonuclease
B21_RS10110	COG0425	Belongs to the sulfur carrier protein TusA family
B21_RS10115	COG2391	methyltransferase activity
B21_RS10120	COG0531	amino acid
B21_RS10125	COG0583	DNA-binding transcription factor activity
B21_RS10130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B21_RS10140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B21_RS10150	COG0131	Imidazoleglycerol-phosphate dehydratase
B21_RS10150	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B21_RS10155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B21_RS10170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B21_RS10170	COG0140	phosphoribosyl-ATP diphosphatase activity
B21_RS10175	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
B21_RS10180	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B21_RS10185	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B21_RS10190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B21_RS10200	COG1662	PFAM IS1 transposase
B21_RS10240	COG2244	polysaccharide biosynthetic process
B21_RS10250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B21_RS10260	COG1088	dTDP-glucose 4,6-dehydratase activity
B21_RS10265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B21_RS10275	COG0438	transferase activity, transferring glycosyl groups
B21_RS10280	COG2327	Polysaccharide pyruvyl transferase
B21_RS10285	COG2244	polysaccharide biosynthetic process
B21_RS10290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B21_RS10295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B21_RS10300	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B21_RS10300	COG0662	Cupin 2, conserved barrel domain protein
B21_RS10305	COG0297	glycogen (starch) synthase activity
B21_RS10310	COG1051	belongs to the nudix hydrolase family
B21_RS10315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B21_RS10320	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B21_RS10325	COG0110	maltose O-acetyltransferase activity
B21_RS10330	COG1216	Glycosyl transferase, family 2
B21_RS10340	COG0438	transferase activity, transferring glycosyl groups
B21_RS10345	COG1045	serine acetyltransferase
B21_RS10350	COG0463	Glycosyl transferase, family 2
B21_RS10355	COG3206	protein involved in exopolysaccharide biosynthesis
B21_RS10355	COG0489	protein tyrosine kinase activity
B21_RS10360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B21_RS10365	COG1596	polysaccharide export
B21_RS10370	COG1253	flavin adenine dinucleotide binding
B21_RS10375	COG2982	Protein involved in outer membrane biogenesis
B21_RS10385	COG0572	uridine kinase
B21_RS10390	COG5001	Diguanylate cyclase
B21_RS10390	COG3447	MASE1 domain protein
B21_RS10390	COG5002	protein histidine kinase activity
B21_RS10395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B21_RS10400	COG0443	Heat shock 70 kDa protein
B21_RS10405	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
B21_RS10410	COG0631	protein serine/threonine phosphatase activity
B21_RS10415	COG4245	von Willebrand factor, type A
B21_RS10440	COG2205	protein histidine kinase activity
B21_RS10445	COG0745	RESPONSE REGULATOR receiver
B21_RS10455	COG0826	peptidase U32
B21_RS10490	COG1063	alcohol dehydrogenase
B21_RS10495	COG3775	system Galactitol-specific IIC component
B21_RS10500	COG3414	Phosphotransferase system galactitol-specific IIB component
B21_RS10505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS10525	COG1830	Aldolase
B21_RS10530	COG2211	Major facilitator Superfamily
B21_RS10535	COG1397	ADP-ribosylglycohydrolase
B21_RS10540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B21_RS10545	COG2188	Transcriptional regulator
B21_RS10550	COG3757	hydrolase, family 25
B21_RS10555	COG0351	phosphomethylpyrimidine kinase
B21_RS10595	COG0489	protein tyrosine kinase activity
B21_RS10605	COG3831	ATPase activity
B21_RS10610	COG3831	ATPase activity
B21_RS10620	COG0714	Associated with various cellular activities
B21_RS10625	COG2425	protein containing a von Willebrand factor type A (vWA) domain
B21_RS10630	COG3552	Protein containing von Willebrand factor type A (VWA) domain
B21_RS10635	COG4715	Zinc finger, swim domain protein
B21_RS10640	COG4808	Protein conserved in bacteria
B21_RS10645	COG4807	Protein conserved in bacteria
B21_RS10650	COG3279	Response regulator of the LytR AlgR family
B21_RS10655	COG3275	phosphorelay sensor kinase activity
B21_RS10660	COG0789	Transcriptional regulator
B21_RS10670	COG1174	glycine betaine transport
B21_RS10675	COG1125	glycine betaine transport
B21_RS10680	COG1174	glycine betaine transport
B21_RS10685	COG1732	Glycine betaine
B21_RS10690	COG1472	Belongs to the glycosyl hydrolase 3 family
B21_RS10695	COG0277	FAD linked oxidase domain protein
B21_RS10700	COG1686	Belongs to the peptidase S11 family
B21_RS10710	COG0586	Pfam SNARE associated Golgi protein
B21_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS10730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B21_RS10740	COG1346	cytolysis
B21_RS10750	COG2949	membrane
B21_RS10760	COG0493	'glutamate synthase
B21_RS10765	COG0167	dihydroorotate dehydrogenase activity
B21_RS10765	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B21_RS10770	COG4211	Belongs to the binding-protein-dependent transport system permease family
B21_RS10775	COG1129	ABC transporter
B21_RS10785	COG1609	Transcriptional regulator
B21_RS10795	COG2311	Membrane
B21_RS10815	COG4771	TonB-dependent receptor
B21_RS10820	COG0833	amino acid
B21_RS10825	COG0583	DNA-binding transcription factor activity
B21_RS10830	COG2855	membrane
B21_RS10840	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B21_RS10840	COG1522	sequence-specific DNA binding
B21_RS10845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B21_RS10855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B21_RS10860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B21_RS10865	COG2313	pseudouridylate synthase activity
B21_RS10870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B21_RS10875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS10875	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B21_RS10875	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS10880	COG1105	Belongs to the carbohydrate kinase PfkB family
B21_RS10885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS10885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS10890	COG2814	Major facilitator Superfamily
B21_RS10905	COG0246	Mannitol dehydrogenase
B21_RS10910	COG0523	cobalamin synthesis protein
B21_RS10915	COG0671	phosphoesterase, PA-phosphatase related
B21_RS10920	COG0791	NLP P60 protein
B21_RS10925	COG2200	EAL domain
B21_RS10930	COG4166	transmembrane transport
B21_RS10935	COG4174	ABC transporter (Permease)
B21_RS10940	COG4239	(ABC) transporter, permease
B21_RS10945	COG4172	Belongs to the ABC transporter superfamily
B21_RS10955	COG2814	Major facilitator Superfamily
B21_RS10960	COG1187	pseudouridine synthase activity
B21_RS10965	COG1061	Type III restriction enzyme res subunit
B21_RS10985	COG3083	sulfuric ester hydrolase activity
B21_RS10995	COG3468	outer membrane autotransporter barrel domain protein
B21_RS11005	COG2197	response regulator
B21_RS11010	COG4235	cytochrome complex assembly
B21_RS11010	COG3088	subunit of a heme lyase
B21_RS11015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B21_RS11020	COG1138	Cytochrome C-type biogenesis protein
B21_RS11030	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B21_RS11035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B21_RS11040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B21_RS11045	COG4133	protoheme IX ABC transporter activity
B21_RS11050	COG3005	denitrification pathway
B21_RS11055	COG3043	anaerobic respiration
B21_RS11060	COG0348	domain, Protein
B21_RS11065	COG0437	4 iron, 4 sulfur cluster binding
B21_RS11075	COG3062	negative regulation of establishment of protein localization
B21_RS11080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS11080	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS11100	COG4615	Cyclic peptide transporter
B21_RS11105	COG3145	DNA-N1-methyladenine dioxygenase activity
B21_RS11110	COG2169	Transcriptional regulator
B21_RS11110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B21_RS11115	COG1477	protein flavinylation
B21_RS11120	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B21_RS11125	COG1662	PFAM IS1 transposase
B21_RS11130	COG2205	protein histidine kinase activity
B21_RS11130	COG0784	Response regulator, receiver
B21_RS11135	COG3852	Histidine kinase
B21_RS11140	COG2204	response regulator
B21_RS11145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B21_RS11150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B21_RS11155	COG2031	fatty acid transporter
B21_RS11160	COG0183	Belongs to the thiolase family
B21_RS11165	COG4676	Protein conserved in bacteria
B21_RS11170	COG5445	Predicted secreted protein (DUF2300)
B21_RS11175	COG2373	Large extracellular alpha-helical protein
B21_RS11180	COG3234	Protein of unknown function (DUF1175)
B21_RS11185	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
B21_RS11190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B21_RS11200	COG3468	outer membrane autotransporter barrel domain protein
B21_RS11210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B21_RS11215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B21_RS11220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B21_RS11225	COG3642	lipopolysaccharide core region biosynthetic process
B21_RS11230	COG0583	DNA-binding transcription factor activity
B21_RS11235	COG0584	glycerophosphoryl diester phosphodiesterase
B21_RS11240	COG2271	Major facilitator Superfamily
B21_RS11245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B21_RS11255	COG0247	lactate metabolic process
B21_RS11260	COG5464	transposase or invertase
B21_RS11270	COG2271	Major facilitator Superfamily
B21_RS11280	COG1414	Transcriptional regulator
B21_RS11345	COG0318	PFAM AMP-dependent synthetase and ligase
B21_RS11355	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B21_RS11370	COG1169	isochorismate synthase
B21_RS11375	COG4575	ribosome binding
B21_RS11380	COG2153	protein acetylation
B21_RS11390	COG5160	protein modification by small protein removal
B21_RS11395	COG2234	aminopeptidase activity
B21_RS11410	COG2801	Transposase and inactivated derivatives
B21_RS11420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B21_RS11425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B21_RS11435	COG0839	Belongs to the complex I subunit 6 family
B21_RS11450	COG1034	ATP synthesis coupled electron transport
B21_RS11455	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B21_RS11460	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B21_RS11480	COG0583	DNA-binding transcription factor activity
B21_RS11485	COG0436	Aminotransferase
B21_RS11495	COG0471	metal ion transport
B21_RS11495	COG0490	domain, Protein
B21_RS11500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B21_RS11520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B21_RS11525	COG0857	belongs to the CobB CobQ family
B21_RS11525	COG0280	phosphate acetyltransferase
B21_RS11530	COG1288	antiporter activity
B21_RS11535	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B21_RS11540	COG0622	Phosphoesterase
B21_RS11545	COG0625	glutathione transferase activity
B21_RS11550	COG0625	glutathione transferase activity
B21_RS11555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B21_RS11560	COG1090	epimerase
B21_RS11565	COG5464	transposase or invertase
B21_RS11570	COG4598	ABC transporter
B21_RS11575	COG4160	amino acid transport
B21_RS11580	COG4215	(ABC) transporter
B21_RS11585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B21_RS11590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B21_RS11595	COG0163	prenyltransferase activity
B21_RS11600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B21_RS11605	COG1286	toxin biosynthetic process
B21_RS11610	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
B21_RS11615	COG0285	dihydrofolate synthase activity
B21_RS11625	COG0586	Pfam SNARE associated Golgi protein
B21_RS11635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B21_RS11650	COG2814	Major facilitator Superfamily
B21_RS11655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B21_RS11670	COG3101	peptidyl-lysine hydroxylation
B21_RS11675	COG0730	response to heat
B21_RS11705	COG3539	Fimbrial protein
B21_RS11710	COG3539	Fimbrial protein
B21_RS11715	COG3539	Fimbrial protein
B21_RS11720	COG3121	Chaperone
B21_RS11725	COG3188	usher protein
B21_RS11730	COG3539	Fimbrial protein
B21_RS11735	COG2062	phosphohistidine phosphatase, SixA
B21_RS11750	COG3691	Protein conserved in bacteria
B21_RS11755	COG2067	long-chain fatty acid transport protein
B21_RS11775	COG2853	Lipoprotein
B21_RS11780	COG2116	formate transmembrane transporter activity
B21_RS11790	COG0583	DNA-binding transcription factor activity
B21_RS11795	COG2610	gluconate transmembrane transporter activity
B21_RS11805	COG0477	Major facilitator Superfamily
B21_RS11810	COG1566	PFAM secretion protein HlyD family protein
B21_RS11815	COG2197	response regulator
B21_RS11820	COG2198	Histidine kinase
B21_RS11820	COG2205	protein histidine kinase activity
B21_RS11820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B21_RS11820	COG0784	Response regulator, receiver
B21_RS11825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B21_RS11830	COG0679	Auxin Efflux Carrier
B21_RS11835	COG0028	Belongs to the TPP enzyme family
B21_RS11865	COG1560	Kdo2-lipid A biosynthetic process
B21_RS11870	COG0436	Aminotransferase
B21_RS11875	COG3275	phosphorelay sensor kinase activity
B21_RS11880	COG3279	Response regulator of the LytR AlgR family
B21_RS11885	COG2207	Transcriptional regulator
B21_RS11890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B21_RS11890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS11890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS11895	COG1363	Peptidase, m42
B21_RS11900	COG0006	proline dipeptidase activity
B21_RS11905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS11910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS11940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B21_RS11945	COG2199	diguanylate cyclase activity
B21_RS11945	COG2200	EAL domain
B21_RS11960	COG3415	Transposase
B21_RS11965	COG3415	Transposase
B21_RS12000	COG0583	DNA-binding transcription factor activity
B21_RS12005	COG0385	Bile acid
B21_RS12010	COG3530	Putative quorum-sensing-regulated virulence factor
B21_RS12030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B21_RS12035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS12040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B21_RS12045	COG2190	(PTS) system
B21_RS12060	COG4884	unkown
B21_RS12060	COG3831	ATPase activity
B21_RS12065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B21_RS12070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B21_RS12075	COG4208	sulfate ABC transporter
B21_RS12080	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B21_RS12085	COG4150	thiosulfate binding
B21_RS12090	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS12095	COG1737	Transcriptional regulator
B21_RS12105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B21_RS12105	COG1263	PTS System
B21_RS12110	COG2837	iron assimilation
B21_RS12135	COG0860	N-Acetylmuramoyl-L-alanine amidase
B21_RS12145	COG2207	Transcriptional regulator
B21_RS12150	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
B21_RS12155	COG4816	utilization protein
B21_RS12165	COG4303	Ethanolamine ammonia lyase large subunit
B21_RS12170	COG4819	ethanolamine utilization protein
B21_RS12175	COG3192	ethanolamine utilization protein
B21_RS12180	COG1454	alcohol dehydrogenase
B21_RS12185	COG4820	ethanolamine utilization protein (EutJ)
B21_RS12190	COG1012	belongs to the aldehyde dehydrogenase family
B21_RS12195	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
B21_RS12200	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
B21_RS12205	COG0280	phosphate acetyltransferase
B21_RS12210	COG4812	Cobalamin adenosyltransferase
B21_RS12215	COG4766	ethanolamine catabolic process
B21_RS12220	COG4917	ethanolamine utilization protein
B21_RS12225	COG4810	utilization protein
B21_RS12230	COG0280	phosphate acetyltransferase
B21_RS12230	COG0281	malic enzyme
B21_RS12235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B21_RS12240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B21_RS12245	COG5342	invasion associated locus B
B21_RS12255	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS12255	COG0493	'glutamate synthase
B21_RS12260	COG3850	Histidine kinase
B21_RS12265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B21_RS12275	COG1393	Belongs to the ArsC family
B21_RS12290	COG0400	carboxylic ester hydrolase activity
B21_RS12295	COG1444	tRNA N-acetyltransferase activity
B21_RS12300	COG2321	neutral zinc metallopeptidase
B21_RS12315	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B21_RS12325	COG2716	regulation of RNA biosynthetic process
B21_RS12330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B21_RS12335	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS12340	COG0651	ATP synthesis coupled electron transport
B21_RS12350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B21_RS12355	COG4237	Hydrogenase 4 membrane
B21_RS12360	COG0651	ATP synthesis coupled electron transport
B21_RS12365	COG3261	NADH dehydrogenase
B21_RS12365	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
B21_RS12370	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B21_RS12375	COG3260	NADH ubiquinone oxidoreductase 20
B21_RS12385	COG3604	Transcriptional regulator
B21_RS12390	COG2116	formate transmembrane transporter activity
B21_RS12395	COG0628	permease
B21_RS12400	COG4783	chaperone-mediated protein folding
B21_RS12405	COG1393	Belongs to the ArsC family
B21_RS12415	COG2233	PERMEase
B21_RS12430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B21_RS12435	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B21_RS12440	COG0248	Ppx GppA phosphatase
B21_RS12445	COG2200	EAL domain
B21_RS12460	COG3133	Outer membrane lipoprotein
B21_RS12475	COG0517	IMP dehydrogenase activity
B21_RS12475	COG0516	GMP reductase activity
B21_RS12485	COG1645	bacterial-type flagellum-dependent swarming motility
B21_RS12500	COG2976	Protein conserved in bacteria
B21_RS12530	COG4953	penicillin-binding protein 1C
B21_RS12535	COG2373	Large extracellular alpha-helical protein
B21_RS12540	COG2897	thiosulfate sulfurtransferase activity
B21_RS12550	COG2801	Transposase and inactivated derivatives
B21_RS12565	COG2975	iron-sulfur cluster assembly
B21_RS12570	COG0633	Ferredoxin
B21_RS12590	COG0822	iron-sulfur transferase activity
B21_RS12610	COG0483	inositol monophosphate 1-phosphatase activity
B21_RS12615	COG1073	alpha beta
B21_RS12620	COG3711	transcriptional antiterminator
B21_RS12625	COG2814	Major facilitator Superfamily
B21_RS12630	COG0583	DNA-binding transcription factor activity
B21_RS12635	COG4638	Rieske (2fe-2S)
B21_RS12660	COG2259	Doxx family
B21_RS12665	COG2017	converts alpha-aldose to the beta-anomer
B21_RS12670	COG1063	alcohol dehydrogenase
B21_RS12675	COG1172	Belongs to the binding-protein-dependent transport system permease family
B21_RS12680	COG1129	ABC transporter
B21_RS12685	COG1879	ABC-type sugar transport system periplasmic component
B21_RS12690	COG0457	Tetratricopeptide repeat
B21_RS12695	COG1940	carbohydrate kinase activity
B21_RS12705	COG1017	nitric oxide dioxygenase activity
B21_RS12705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B21_RS12710	COG0347	Belongs to the P(II) protein family
B21_RS12715	COG2204	response regulator
B21_RS12720	COG3170	Tfp pilus assembly protein FimV
B21_RS12725	COG2205	protein histidine kinase activity
B21_RS12750	COG0560	Phosphoserine phosphatase
B21_RS12755	COG1737	Transcriptional regulator
B21_RS12760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS12785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B21_RS12805	COG0681	Belongs to the peptidase S26 family
B21_RS12815	COG3086	response to oxidative stress
B21_RS12820	COG3026	antisigma factor binding
B21_RS12825	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
B21_RS12830	COG1595	DNA-templated transcription, initiation
B21_RS12840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B21_RS12850	COG0513	Belongs to the DEAD box helicase family
B21_RS12860	COG0583	DNA-binding transcription factor activity
B21_RS12880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B21_RS12890	COG3118	belongs to the thioredoxin family
B21_RS12895	COG3148	PFAM DTW domain containing protein
B21_RS12900	COG1042	CoA-binding domain protein
B21_RS12900	COG0045	succinate-CoA ligase (ADP-forming) activity
B21_RS12900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B21_RS12905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B21_RS12910	COG5544	Lipoprotein
B21_RS12915	COG0477	Major facilitator Superfamily
B21_RS12940	COG0542	response to heat
B21_RS12950	COG0564	pseudouridine synthase activity
B21_RS12955	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B21_RS12965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B21_RS12970	COG1605	Chorismate mutase
B21_RS12970	COG0077	Prephenate dehydratase
B21_RS12975	COG1605	Chorismate mutase
B21_RS12975	COG0287	Prephenate dehydrogenase
B21_RS12980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B21_RS12995	COG2199	diguanylate cyclase activity
B21_RS13000	COG2885	chlorophyll binding
B21_RS13025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B21_RS13030	COG4137	Cytochrome C assembly protein
B21_RS13035	COG4536	flavin adenine dinucleotide binding
B21_RS13055	COG0497	DNA recombination
B21_RS13060	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B21_RS13070	COG2867	negative regulation of translational initiation
B21_RS13080	COG0582	viral genome integration into host DNA
B21_RS13090	COG1475	DNA binding
B21_RS13110	COG0579	oxidoreductase
B21_RS13115	COG1012	belongs to the aldehyde dehydrogenase family
B21_RS13120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B21_RS13125	COG1113	amino acid transport
B21_RS13130	COG1802	Transcriptional regulator
B21_RS13135	COG1652	LysM domain
B21_RS13140	COG0401	homolog of Blt101
B21_RS13145	COG0640	Transcriptional regulator
B21_RS13150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B21_RS13155	COG2916	Histone family protein nucleoid-structuring protein H-NS
B21_RS13170	COG4575	ribosome binding
B21_RS13175	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B21_RS13185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B21_RS13190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B21_RS13195	COG4175	Glycine betaine
B21_RS13200	COG4176	ABC-type proline glycine betaine transport system permease component
B21_RS13205	COG2113	Glycine betaine
B21_RS13210	COG2814	Major facilitator Superfamily
B21_RS13215	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B21_RS13225	COG1846	Transcriptional regulator
B21_RS13230	COG1566	PFAM secretion protein HlyD family protein
B21_RS13235	COG2814	Major facilitator Superfamily
B21_RS13250	COG1238	metal cluster binding
B21_RS13255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B21_RS13290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B21_RS13315	COG1546	Belongs to the CinA family
B21_RS13320	COG2951	lytic endotransglycosylase activity
B21_RS13325	COG3730	PTS system glucitol sorbitol-specific
B21_RS13330	COG3732	PTS system glucitol sorbitol-specific
B21_RS13340	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS13345	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS13350	COG1349	DNA-binding transcription factor activity
B21_RS13355	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B21_RS13355	COG0517	IMP dehydrogenase activity
B21_RS13375	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
B21_RS13380	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS13385	COG1609	Transcriptional regulator
B21_RS13390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B21_RS13390	COG1263	PTS System
B21_RS13395	COG2723	6-phospho-beta-galactosidase activity
B21_RS13400	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B21_RS13410	COG3260	NADH ubiquinone oxidoreductase 20
B21_RS13415	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B21_RS13420	COG3261	NADH dehydrogenase
B21_RS13420	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
B21_RS13425	COG0650	Formate hydrogenlyase subunit 4
B21_RS13430	COG0651	ATP synthesis coupled electron transport
B21_RS13435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS13450	COG0375	protein maturation
B21_RS13455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B21_RS13460	COG0298	carbon dioxide binding
B21_RS13465	COG0409	Hydrogenase expression formation protein
B21_RS13470	COG0309	Hydrogenase expression formation protein (HypE)
B21_RS13475	COG3604	Transcriptional regulator
B21_RS13490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B21_RS13495	COG1349	DNA-binding transcription factor activity
B21_RS13500	COG2084	Dehydrogenase
B21_RS13505	COG3395	kinase activity
B21_RS13510	COG0235	Class ii aldolase
B21_RS13515	COG3622	Belongs to the hyi family
B21_RS13520	COG2610	gluconate transmembrane transporter activity
B21_RS13525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B21_RS13530	COG4942	peptidase
B21_RS13530	COG1388	LysM domain
B21_RS13585	COG2234	aminopeptidase activity
B21_RS13590	COG3385	transposase activity
B21_RS13605	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B21_RS13615	COG0720	synthase
B21_RS13620	COG0644	oxidoreductase
B21_RS13625	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B21_RS13630	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B21_RS13635	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B21_RS13640	COG2086	electron transfer activity
B21_RS13645	COG0477	Major facilitator Superfamily
B21_RS13650	COG0277	FAD linked oxidase domain protein
B21_RS13655	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS13660	COG2223	nitrite transmembrane transporter activity
B21_RS13665	COG1070	Carbohydrate kinase
B21_RS13670	COG0602	queuosine metabolic process
B21_RS13680	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B21_RS13695	COG3956	TIGRFAM MazG family protein
B21_RS13700	COG2337	Toxic component of a toxin-antitoxin (TA) module
B21_RS13705	COG2336	PFAM SpoVT AbrB
B21_RS13710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B21_RS13715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B21_RS13720	COG4999	Histidine kinase
B21_RS13720	COG3437	response regulator, receiver
B21_RS13720	COG2205	protein histidine kinase activity
B21_RS13720	COG3850	Histidine kinase
B21_RS13725	COG4948	Mandelate Racemase Muconate Lactonizing
B21_RS13730	COG4948	Mandelate Racemase Muconate Lactonizing
B21_RS13735	COG2271	Major facilitator Superfamily
B21_RS13740	COG0716	FMN binding
B21_RS13745	COG0564	pseudouridine synthase activity
B21_RS13750	COG3098	single-species biofilm formation
B21_RS13770	COG1611	Belongs to the LOG family
B21_RS13775	COG0814	amino acid
B21_RS13780	COG1760	l-serine dehydratase
B21_RS13790	COG1454	alcohol dehydrogenase
B21_RS13795	COG0235	Class ii aldolase
B21_RS13805	COG0235	Class ii aldolase
B21_RS13815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B21_RS13820	COG1609	Transcriptional regulator
B21_RS13825	COG1172	Belongs to the binding-protein-dependent transport system permease family
B21_RS13830	COG1129	ABC transporter
B21_RS13840	COG1070	Carbohydrate kinase
B21_RS13850	COG1349	DNA-binding transcription factor activity
B21_RS13860	COG2363	Small membrane protein
B21_RS13865	COG0583	DNA-binding transcription factor activity
B21_RS13875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B21_RS13880	COG2166	iron-sulfur cluster assembly
B21_RS13885	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B21_RS13890	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B21_RS13910	COG0860	N-Acetylmuramoyl-L-alanine amidase
B21_RS13915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B21_RS13915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B21_RS13920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B21_RS13925	COG1074	ATP-dependent DNA helicase activity
B21_RS13935	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B21_RS13940	COG4967	type IV pilus modification protein PilV
B21_RS13950	COG4795	General secretion pathway protein
B21_RS13955	COG2165	general secretion pathway protein
B21_RS13970	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
B21_RS13995	COG0861	Integral membrane protein TerC family
B21_RS14005	COG0667	Aldo Keto reductase
B21_RS14020	COG1609	Transcriptional regulator
B21_RS14030	COG0583	DNA-binding transcription factor activity
B21_RS14035	COG1794	racemase activity, acting on amino acids and derivatives
B21_RS14040	COG2814	Major facilitator Superfamily
B21_RS14045	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS14050	COG2963	transposase activity
B21_RS14055	COG2801	Transposase and inactivated derivatives
B21_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS14070	COG0183	Belongs to the thiolase family
B21_RS14075	COG0814	amino acid
B21_RS14080	COG2771	luxR family
B21_RS14090	COG2801	Transposase and inactivated derivatives
B21_RS14095	COG3387	PFAM Glycoside hydrolase 15-related
B21_RS14105	COG4942	peptidase
B21_RS14110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B21_RS14115	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B21_RS14120	COG2080	2 iron, 2 sulfur cluster binding
B21_RS14125	COG3829	transcription factor binding
B21_RS14130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B21_RS14135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B21_RS14140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B21_RS14150	COG0549	Belongs to the carbamate kinase family
B21_RS14155	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B21_RS14155	COG3608	succinylglutamate desuccinylase aspartoacylase
B21_RS14160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B21_RS14165	COG2068	MobA-Related Protein
B21_RS14170	COG0493	'glutamate synthase
B21_RS14170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS14175	COG0402	S-adenosylhomocysteine deaminase activity
B21_RS14180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B21_RS14185	COG2080	2 iron, 2 sulfur cluster binding
B21_RS14185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B21_RS14190	COG2233	PERMEase
B21_RS14195	COG0402	S-adenosylhomocysteine deaminase activity
B21_RS14200	COG2252	PERMEase
B21_RS14205	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS14210	COG0493	'glutamate synthase
B21_RS14210	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS14220	COG2233	PERMEase
B21_RS14235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B21_RS14245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B21_RS14250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B21_RS14255	COG4974	Belongs to the 'phage' integrase family
B21_RS14260	COG0716	FMN binding
B21_RS14270	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B21_RS14280	COG1272	protein, Hemolysin III
B21_RS14290	COG2723	6-phospho-beta-galactosidase activity
B21_RS14295	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS14315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B21_RS14320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B21_RS14325	COG0006	proline dipeptidase activity
B21_RS14340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B21_RS14345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B21_RS14365	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B21_RS14365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B21_RS14370	COG1703	isobutyryl-CoA mutase activity
B21_RS14375	COG1024	Enoyl-CoA hydratase
B21_RS14380	COG0427	acetyl-CoA hydrolase
B21_RS14385	COG0583	DNA-binding transcription factor activity
B21_RS14390	COG2968	Membrane
B21_RS14395	COG1279	arginine transmembrane transporter activity
B21_RS14400	COG0668	transmembrane transport
B21_RS14405	COG0191	fructose-bisphosphate aldolase activity
B21_RS14420	COG1072	(Pantothenic acid kinase))
B21_RS14425	COG3722	fumarate hydratase activity
B21_RS14430	COG1494	fructose-1,6-bisphosphatase
B21_RS14435	COG1063	alcohol dehydrogenase
B21_RS14440	COG2213	PTS system mannitol-specific
B21_RS14445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS14450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B21_RS14455	COG0501	Belongs to the peptidase M48B family
B21_RS14465	COG1166	arginine decarboxylase activity
B21_RS14490	COG2814	Major facilitator Superfamily
B21_RS14500	COG2356	endonuclease I
B21_RS14505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B21_RS14510	COG0189	ligase activity
B21_RS14525	COG2805	Type II/IV secretion system protein
B21_RS14530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B21_RS14535	COG0762	integral membrane protein
B21_RS14545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B21_RS14550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B21_RS14560	COG0252	asparaginase activity
B21_RS14575	COG3171	Protein conserved in bacteria
B21_RS14585	COG1194	a g-specific adenine glycosylase
B21_RS14600	COG2211	Major facilitator Superfamily
B21_RS14605	COG1982	Orn Lys Arg decarboxylase major
B21_RS14610	COG1811	Na channel or pump
B21_RS14620	COG0582	viral genome integration into host DNA
B21_RS14715	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B21_RS14745	COG2165	general secretion pathway protein
B21_RS14750	COG1459	type II secretion system
B21_RS14755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B21_RS14775	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B21_RS14780	COG3064	Membrane
B21_RS14790	COG1620	l-lactate permease
B21_RS14795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B21_RS14800	COG3193	protein, possibly involved in utilization of glycolate and propanediol
B21_RS14805	COG0247	lactate metabolic process
B21_RS14810	COG0277	FAD linked oxidase domain protein
B21_RS14815	COG0277	FAD linked oxidase domain protein
B21_RS14820	COG2186	Transcriptional regulator
B21_RS14825	COG0456	acetyltransferase
B21_RS14830	COG0318	PFAM AMP-dependent synthetase and ligase
B21_RS14840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B21_RS14845	COG0156	8-amino-7-oxononanoate synthase activity
B21_RS14855	COG0795	lipopolysaccharide-transporting ATPase activity
B21_RS14860	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
B21_RS14870	COG2244	polysaccharide biosynthetic process
B21_RS14875	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B21_RS14880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B21_RS14885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B21_RS14890	COG0306	phosphate transporter
B21_RS14895	COG0754	glutathionylspermidine amidase activity
B21_RS14900	COG0625	glutathione transferase activity
B21_RS14905	COG0298	carbon dioxide binding
B21_RS14910	COG0375	protein maturation
B21_RS14915	COG1773	rubredoxin
B21_RS14920	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B21_RS14925	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
B21_RS14930	COG5557	Pfam Polysulphide reductase, NrfD
B21_RS14935	COG0437	4 iron, 4 sulfur cluster binding
B21_RS14940	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
B21_RS14960	COG0667	Aldo Keto reductase
B21_RS14970	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS14975	COG0848	biopolymer transport protein
B21_RS14980	COG0811	peptide transport
B21_RS14990	COG0626	cystathionine gamma-synthase activity
B21_RS14995	COG0586	Pfam SNARE associated Golgi protein
B21_RS15000	COG2207	Transcriptional regulator
B21_RS15010	COG1979	alcohol dehydrogenase
B21_RS15015	COG0656	L-ascorbic acid biosynthetic process
B21_RS15025	COG4238	major outer membrane lipoprotein
B21_RS15030	COG1032	radical SAM domain protein
B21_RS15035	COG2132	Multicopper oxidase
B21_RS15040	COG0204	Acyl-transferase
B21_RS15045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B21_RS15050	COG4166	transmembrane transport
B21_RS15055	COG2944	sequence-specific DNA binding
B21_RS15065	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B21_RS15070	COG3111	PFAM Bacterial OB fold (BOF) protein
B21_RS15075	COG0745	RESPONSE REGULATOR receiver
B21_RS15080	COG0642	Histidine kinase
B21_RS15090	COG2249	NAD(P)H dehydrogenase (quinone) activity
B21_RS15095	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B21_RS15100	COG0187	DNA topoisomerase II activity
B21_RS15105	COG3150	esterase
B21_RS15110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B21_RS15115	COG3151	Protein conserved in bacteria
B21_RS15120	COG0494	nUDIX hydrolase
B21_RS15125	COG1538	Outer membrane efflux protein
B21_RS15140	COG0754	glutathionylspermidine amidase activity
B21_RS15145	COG3384	dioxygenase
B21_RS15165	COG2960	long-chain fatty acid transporting porin activity
B21_RS15170	COG3539	Fimbrial protein
B21_RS15175	COG3188	usher protein
B21_RS15180	COG3121	Chaperone
B21_RS15185	COG3539	Fimbrial protein
B21_RS15195	COG1585	Membrane protein implicated in regulation of membrane protease activity
B21_RS15200	COG2268	Band 7 protein
B21_RS15225	COG3025	triphosphatase activity
B21_RS15235	COG4991	sh3 domain protein
B21_RS15250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B21_RS15260	COG0583	DNA-binding transcription factor activity
B21_RS15265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B21_RS15270	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B21_RS15275	COG0471	metal ion transport
B21_RS15285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B21_RS15290	COG0358	DNA primase activity
B21_RS15295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B21_RS15310	COG2375	cellular response to nickel ion
B21_RS15315	COG1695	Transcriptional regulator
B21_RS15320	COG0840	transmembrane signaling receptor activity
B21_RS15330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B21_RS15335	COG1609	Transcriptional regulator
B21_RS15340	COG3250	beta-galactosidase activity
B21_RS15345	COG2731	YhcH YjgK YiaL family protein
B21_RS15350	COG0531	amino acid
B21_RS15360	COG3408	Glycogen debranching enzyme
B21_RS15360	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
B21_RS15365	COG1902	pentaerythritol trinitrate reductase activity
B21_RS15365	COG0446	pyridine nucleotide-disulphide oxidoreductase
B21_RS15370	COG5499	transcription regulator containing HTH domain
B21_RS15375	COG4680	protein conserved in bacteria
B21_RS15390	COG1451	nucleotide metabolic process
B21_RS15395	COG2949	membrane
B21_RS15400	COG0673	inositol 2-dehydrogenase activity
B21_RS15405	COG0861	Integral membrane protein TerC family
B21_RS15410	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B21_RS15420	COG2721	sulfolactate sulfo-lyase activity
B21_RS15430	COG2271	Major facilitator Superfamily
B21_RS15435	COG2186	Transcriptional regulator
B21_RS15440	COG0586	Pfam SNARE associated Golgi protein
B21_RS15450	COG1422	Protein of unknown function (DUF1090)
B21_RS15455	COG4575	ribosome binding
B21_RS15460	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
B21_RS15470	COG2259	Doxx family
B21_RS15475	COG0435	Glutathione S-transferase
B21_RS15480	COG3152	Membrane
B21_RS15485	COG3152	Membrane
B21_RS15490	COG0583	DNA-binding transcription factor activity
B21_RS15495	COG1741	Belongs to the pirin family
B21_RS15510	COG0814	amino acid
B21_RS15515	COG1760	l-serine dehydratase
B21_RS15520	COG0251	oxidation-reduction process
B21_RS15525	COG1882	Formate acetyltransferase
B21_RS15530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B21_RS15540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B21_RS15545	COG0583	DNA-binding transcription factor activity
B21_RS15565	COG1929	Belongs to the glycerate kinase type-1 family
B21_RS15570	COG2084	Dehydrogenase
B21_RS15580	COG2271	Major facilitator Superfamily
B21_RS15585	COG2721	sulfolactate sulfo-lyase activity
B21_RS15590	COG2002	toxin-antitoxin pair type II binding
B21_RS15600	COG1349	DNA-binding transcription factor activity
B21_RS15610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B21_RS15620	COG3716	PTS system mannose fructose sorbose family IID component
B21_RS15625	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS15630	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B21_RS15635	COG2222	sugar isomerase
B21_RS15645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B21_RS15650	COG3715	PTS system
B21_RS15655	COG3716	PTS system mannose fructose sorbose family IID component
B21_RS15660	COG0363	glucosamine-6-phosphate deaminase activity
B21_RS15665	COG3539	Fimbrial protein
B21_RS15670	COG3121	Chaperone
B21_RS15675	COG3188	usher protein
B21_RS15680	COG3539	Fimbrial protein
B21_RS15685	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B21_RS15690	COG3107	peptidoglycan biosynthetic process
B21_RS15705	COG2823	Periplasmic or secreted lipoprotein
B21_RS15710	COG0701	Predicted permease
B21_RS15715	COG0702	epimerase
B21_RS15720	COG0693	protein deglycase activity
B21_RS15735	COG3153	acetyltransferase
B21_RS15740	COG3154	lipid carrier protein
B21_RS15745	COG0826	peptidase U32
B21_RS15750	COG0826	peptidase U32
B21_RS15755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B21_RS15760	COG0814	amino acid
B21_RS15770	COG0513	Belongs to the DEAD box helicase family
B21_RS15805	COG0195	Participates in both transcription termination and antitermination
B21_RS15825	COG2194	sulfuric ester hydrolase activity
B21_RS15835	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B21_RS15845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B21_RS15850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B21_RS15860	COG1534	Rna-binding protein
B21_RS15865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B21_RS15870	COG2027	D-alanyl-D-alanine carboxypeptidase
B21_RS15880	COG0697	spore germination
B21_RS15895	COG0142	geranyltranstransferase activity
B21_RS15900	COG3423	Transcriptional regulator
B21_RS15910	COG5007	Belongs to the BolA IbaG family
B21_RS15915	COG3113	response to antibiotic
B21_RS15920	COG2854	intermembrane phospholipid transfer
B21_RS15925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B21_RS15930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B21_RS15935	COG1127	ABC transporter
B21_RS15940	COG0530	calcium, potassium:sodium antiporter activity
B21_RS15945	COG0517	IMP dehydrogenase activity
B21_RS15945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B21_RS15950	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B21_RS15955	COG3117	lipopolysaccharide transmembrane transporter activity
B21_RS15960	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B21_RS15965	COG1137	ATPase activity
B21_RS15970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B21_RS15975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B21_RS15990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS15995	COG0515	serine threonine protein kinase
B21_RS16005	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
B21_RS16010	COG2198	Histidine kinase
B21_RS16010	COG5002	protein histidine kinase activity
B21_RS16010	COG0784	Response regulator, receiver
B21_RS16015	COG1242	4 iron, 4 sulfur cluster binding
B21_RS16020	COG0070	glutamate synthase
B21_RS16020	COG0069	glutamate synthase activity
B21_RS16020	COG0067	glutamate synthase
B21_RS16025	COG0493	'glutamate synthase
B21_RS16030	COG4804	nuclease activity
B21_RS16040	COG2731	YhcH YjgK YiaL family protein
B21_RS16070	COG3069	C4-dicarboxylate transmembrane transporter activity
B21_RS16075	COG2969	positive regulation of protein catabolic process
B21_RS16080	COG0625	glutathione transferase activity
B21_RS16095	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B21_RS16100	COG3105	Protein conserved in bacteria
B21_RS16105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B21_RS16110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B21_RS16130	COG2732	(Barnase) inhibitor
B21_RS16150	COG0583	DNA-binding transcription factor activity
B21_RS16155	COG0312	modulator of DNA gyrase
B21_RS16160	COG3164	Protein of unknown function
B21_RS16165	COG1530	ribonuclease E activity
B21_RS16170	COG0424	maF-like protein
B21_RS16175	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B21_RS16180	COG1792	Involved in formation and maintenance of cell shape
B21_RS16185	COG1077	Cell shape determining protein MreB Mrl
B21_RS16195	COG2200	EAL domain
B21_RS16195	COG2199	diguanylate cyclase activity
B21_RS16200	COG0604	alcohol dehydrogenase
B21_RS16220	COG0511	ligase activity, forming carbon-carbon bonds
B21_RS16225	COG0439	Biotin carboxylase
B21_RS16230	COG3924	membrane
B21_RS16235	COG4145	pantothenate transmembrane transporter activity
B21_RS16245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B21_RS16255	COG2189	Belongs to the N(4) N(6)-methyltransferase family
B21_RS16265	COG1309	transcriptional regulator
B21_RS16270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B21_RS16275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B21_RS16290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B21_RS16295	COG4597	amino acid ABC transporter
B21_RS16300	COG0765	amino acid transport
B21_RS16305	COG1126	abc transporter atp-binding protein
B21_RS16345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B21_RS16365	COG0551	DNA topoisomerase type I activity
B21_RS16375	COG0758	DNA mediated transformation
B21_RS16395	COG0569	domain protein
B21_RS16405	COG3036	rescue of stalled ribosome
B21_RS16410	COG0789	Transcriptional regulator
B21_RS16450	COG0201	protein transport
B21_RS16540	COG0089	rRNA binding
B21_RS16565	COG3409	Peptidoglycan-binding domain 1 protein
B21_RS16565	COG3267	Type II secretory pathway component ExeA
B21_RS16570	COG3031	protein transport across the cell outer membrane
B21_RS16575	COG1450	Type ii and iii secretion system protein
B21_RS16580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B21_RS16585	COG1459	type II secretion system
B21_RS16590	COG2165	general secretion pathway protein
B21_RS16595	COG2165	general secretion pathway protein
B21_RS16600	COG2165	general secretion pathway protein
B21_RS16605	COG4795	General secretion pathway protein
B21_RS16610	COG3156	type II secretion system protein K
B21_RS16615	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B21_RS16620	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B21_RS16625	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B21_RS16630	COG2193	ferroxidase activity
B21_RS16635	COG2906	2 iron, 2 sulfur cluster binding
B21_RS16640	COG3979	chitinase
B21_RS16680	COG2964	Protein conserved in bacteria
B21_RS16685	COG0545	Peptidyl-prolyl cis-trans isomerase
B21_RS16695	COG1047	Peptidyl-prolyl cis-trans
B21_RS16700	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B21_RS16715	COG0488	(ABC) transporter
B21_RS16720	COG0429	hydrolase of the alpha beta-hydrolase fold
B21_RS16730	COG3954	Phosphoribulokinase
B21_RS16735	COG1765	OsmC-like protein
B21_RS16745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B21_RS16750	COG1289	transmembrane transporter activity
B21_RS16755	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B21_RS16760	COG0512	Glutamine amidotransferase of anthranilate synthase
B21_RS16765	COG2184	nucleotidyltransferase activity
B21_RS16775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B21_RS16785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B21_RS16790	COG2146	nitrite reductase [NAD(P)H] activity
B21_RS16795	COG2116	formate transmembrane transporter activity
B21_RS16810	COG0531	amino acid
B21_RS16815	COG2222	sugar isomerase
B21_RS16820	COG1082	Xylose isomerase domain protein TIM barrel
B21_RS16825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B21_RS16830	COG2188	Transcriptional regulator
B21_RS16835	COG0626	cystathionine gamma-synthase activity
B21_RS16845	COG0626	cystathionine gamma-synthase activity
B21_RS16860	COG1735	metal-dependent hydrolase with the TIM-barrel fold
B21_RS16865	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B21_RS16870	COG3457	Alanine racemase
B21_RS16880	COG2188	Transcriptional regulator
B21_RS16885	COG0180	Tryptophanyl-tRNA synthetase
B21_RS16890	COG0546	phosphoglycolate phosphatase activity
B21_RS16895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B21_RS16900	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B21_RS16905	COG3266	domain, Protein
B21_RS16920	COG4796	Type ii and iii secretion system protein
B21_RS16935	COG3166	PFAM Fimbrial assembly family protein
B21_RS16940	COG4972	Pilus assembly protein
B21_RS16945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B21_RS16950	COG0494	nUDIX hydrolase
B21_RS16960	COG1011	Hydrolase
B21_RS16965	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B21_RS16975	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B21_RS17000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B21_RS17005	COG2183	response to ionizing radiation
B21_RS17010	COG1918	ferrous iron import across plasma membrane
B21_RS17015	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B21_RS17025	COG5464	transposase or invertase
B21_RS17045	COG2610	gluconate transmembrane transporter activity
B21_RS17050	COG1640	4-alpha-glucanotransferase
B21_RS17055	COG0058	SHG alpha-glucan phosphorylase activity
B21_RS17070	COG1690	Belongs to the RtcB family
B21_RS17075	COG4650	regulator
B21_RS17080	COG1349	DNA-binding transcription factor activity
B21_RS17095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B21_RS17110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B21_RS17115	COG0058	SHG alpha-glucan phosphorylase activity
B21_RS17140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B21_RS17145	COG2095	MarC family integral membrane protein
B21_RS17150	COG2610	gluconate transmembrane transporter activity
B21_RS17155	COG3265	gluconokinase activity
B21_RS17160	COG1609	Transcriptional regulator
B21_RS17165	COG1741	Belongs to the pirin family
B21_RS17170	COG0673	inositol 2-dehydrogenase activity
B21_RS17175	COG1247	-acetyltransferase
B21_RS17180	COG3157	Type VI secretion system effector, Hcp
B21_RS17195	COG0405	Gamma-glutamyltransferase
B21_RS17205	COG0584	glycerophosphoryl diester phosphodiesterase
B21_RS17210	COG3842	ATPase activity
B21_RS17215	COG0395	ABC-type sugar transport system, permease component
B21_RS17220	COG1175	transmembrane transport
B21_RS17225	COG1653	transport
B21_RS17235	COG0410	ABC transporter
B21_RS17240	COG0411	ABC transporter
B21_RS17245	COG4177	L-phenylalanine transmembrane transporter activity
B21_RS17250	COG0559	Belongs to the binding-protein-dependent transport system permease family
B21_RS17255	COG0683	leucine binding
B21_RS17260	COG0456	acetyltransferase
B21_RS17270	COG0683	leucine binding
B21_RS17275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B21_RS17280	COG2177	Part of the ABC transporter FtsEX involved in
B21_RS17285	COG2884	Cell division ATP-binding protein ftsE
B21_RS17290	COG0552	protein localization to endoplasmic reticulum
B21_RS17295	COG0742	ribosomal rna small subunit methyltransferase
B21_RS17300	COG3776	membrane
B21_RS17310	COG3714	YhhN family
B21_RS17325	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B21_RS17335	COG0477	Major facilitator Superfamily
B21_RS17340	COG0628	permease
B21_RS17345	COG2091	lysine biosynthetic process via aminoadipic acid
B21_RS17350	COG0747	negative chemotaxis
B21_RS17355	COG0601	transmembrane transport
B21_RS17360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B21_RS17365	COG0444	Belongs to the ABC transporter superfamily
B21_RS17380	COG3209	COG3209 Rhs family protein
B21_RS17395	COG5433	transposase activity
B21_RS17400	COG0842	Transport permease protein
B21_RS17405	COG0842	Transport permease protein
B21_RS17405	COG1129	ABC transporter
B21_RS17410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B21_RS17440	COG2081	HI0933 family
B21_RS17445	COG0306	phosphate transporter
B21_RS17455	COG0589	response to stress
B21_RS17460	COG3104	oligopeptide transport
B21_RS17470	COG0339	signal peptide processing
B21_RS17475	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B21_RS17480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B21_RS17495	COG0640	Transcriptional regulator
B21_RS17500	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B21_RS17505	COG1393	Belongs to the ArsC family
B21_RS17515	COG3065	identical protein binding
B21_RS17520	COG2197	response regulator
B21_RS17525	COG1285	pathogenesis
B21_RS17540	COG3247	response to pH
B21_RS17545	COG2771	luxR family
B21_RS17555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B21_RS17560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B21_RS17565	COG2207	Transcriptional regulator
B21_RS17570	COG2207	Transcriptional regulator
B21_RS17575	COG0076	glutamate decarboxylase activity
B21_RS17580	COG1858	cytochrome C peroxidase
B21_RS17590	COG2197	response regulator
B21_RS17595	COG0583	DNA-binding transcription factor activity
B21_RS17600	COG1295	ribonuclease BN
B21_RS17605	COG0477	Major facilitator Superfamily
B21_RS17610	COG2982	Protein involved in outer membrane biogenesis
B21_RS17615	COG2200	EAL domain
B21_RS17630	COG0612	Peptidase, M16
B21_RS17640	COG2200	EAL domain
B21_RS17640	COG2199	diguanylate cyclase activity
B21_RS17645	COG0457	Tetratricopeptide repeat
B21_RS17645	COG3118	belongs to the thioredoxin family
B21_RS17650	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B21_RS17655	COG1215	transferase activity, transferring glycosyl groups
B21_RS17660	COG1215	transferase activity, transferring glycosyl groups
B21_RS17685	COG2194	sulfuric ester hydrolase activity
B21_RS17710	COG0814	amino acid
B21_RS17715	COG4608	Belongs to the ABC transporter superfamily
B21_RS17720	COG0444	Belongs to the ABC transporter superfamily
B21_RS17725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B21_RS17730	COG0601	transmembrane transport
B21_RS17740	COG0747	negative chemotaxis
B21_RS17755	COG2194	sulfuric ester hydrolase activity
B21_RS17760	COG2223	nitrite transmembrane transporter activity
B21_RS17765	COG5571	outer membrane autotransporter
B21_RS17770	COG2818	Glycosylase
B21_RS17775	COG0456	acetyltransferase
B21_RS17780	COG0243	molybdopterin cofactor binding
B21_RS17785	COG2885	chlorophyll binding
B21_RS17800	COG2944	sequence-specific DNA binding
B21_RS17805	COG1278	Cold shock
B21_RS17815	COG2963	transposase activity
B21_RS17820	COG2801	Transposase and inactivated derivatives
B21_RS17840	COG3274	enterobacterial common antigen metabolic process
B21_RS17845	COG4682	membrane
B21_RS17850	COG4682	membrane
B21_RS17855	COG1070	Carbohydrate kinase
B21_RS17865	COG4213	ABC transporter substrate-binding protein
B21_RS17875	COG4214	carbohydrate transport
B21_RS17880	COG1609	Transcriptional regulator
B21_RS17880	COG2207	Transcriptional regulator
B21_RS17885	COG2992	FlgJ-related protein
B21_RS17890	COG0366	Alpha amylase catalytic
B21_RS17895	COG3977	Valine--pyruvate aminotransferase
B21_RS17905	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B21_RS17910	COG1414	Transcriptional regulator
B21_RS17920	COG2731	YhcH YjgK YiaL family protein
B21_RS17925	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B21_RS17930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B21_RS17935	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B21_RS17940	COG1070	Carbohydrate kinase
B21_RS17945	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B21_RS17950	COG3623	hexulose-6-phosphate isomerase
B21_RS17955	COG0235	Class ii aldolase
B21_RS17965	COG2211	Major facilitator Superfamily
B21_RS17975	COG3713	MltA-interacting MipA family protein
B21_RS17980	COG0583	DNA-binding transcription factor activity
B21_RS17985	COG1566	PFAM secretion protein HlyD family protein
B21_RS18000	COG1012	belongs to the aldehyde dehydrogenase family
B21_RS18005	COG1454	alcohol dehydrogenase
B21_RS18010	COG3276	selenocysteine insertion sequence binding
B21_RS18020	COG0625	glutathione transferase activity
B21_RS18025	COG3209	COG3209 Rhs family protein
B21_RS18030	COG1413	lyase activity
B21_RS18035	COG3209	COG3209 Rhs family protein
B21_RS18040	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B21_RS18050	COG1566	PFAM secretion protein HlyD family protein
B21_RS18060	COG2213	PTS system mannitol-specific
B21_RS18060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS18070	COG3722	fumarate hydratase activity
B21_RS18090	COG5295	Hep Hag repeat protein
B21_RS18095	COG1620	l-lactate permease
B21_RS18100	COG2186	Transcriptional regulator
B21_RS18110	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B21_RS18115	COG1045	serine acetyltransferase
B21_RS18130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B21_RS18135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B21_RS18145	COG4942	peptidase
B21_RS18150	COG2861	carbohydrate metabolic process
B21_RS18155	COG1216	Glycosyl transferase, family 2
B21_RS18165	COG0156	8-amino-7-oxononanoate synthase activity
B21_RS18175	COG0859	PFAM glycosyl transferase family 9
B21_RS18180	COG0859	PFAM glycosyl transferase family 9
B21_RS18185	COG3307	-O-antigen
B21_RS18190	COG1216	Glycosyl transferase, family 2
B21_RS18195	COG1442	glycosyl transferase family 8
B21_RS18200	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B21_RS18225	COG0515	serine threonine protein kinase
B21_RS18230	COG0438	transferase activity, transferring glycosyl groups
B21_RS18235	COG0859	PFAM glycosyl transferase family 9
B21_RS18240	COG1519	Transferase
B21_RS18270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B21_RS18295	COG1561	YicC-like family, N-terminal region
B21_RS18300	COG3645	SOS response
B21_RS18305	COG2860	membrane
B21_RS18315	COG0194	GDP metabolic process
B21_RS18325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B21_RS18330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B21_RS18335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B21_RS18345	COG0786	glutamate:sodium symporter activity
B21_RS18350	COG2233	PERMEase
B21_RS18355	COG2982	Protein involved in outer membrane biogenesis
B21_RS18360	COG1501	Belongs to the glycosyl hydrolase 31 family
B21_RS18365	COG2211	Major facilitator Superfamily
B21_RS18375	COG0582	viral genome integration into host DNA
B21_RS18385	COG1609	Transcriptional regulator
B21_RS18390	COG2271	Major facilitator Superfamily
B21_RS18445	COG2963	transposase activity
B21_RS18450	COG2826	transposase and inactivated derivatives, IS30 family
B21_RS18480	COG2814	Major facilitator Superfamily
B21_RS18485	COG0697	spore germination
B21_RS18490	COG1464	Belongs to the NlpA lipoprotein family
B21_RS18515	COG2252	PERMEase
B21_RS18525	COG2271	Major facilitator Superfamily
B21_RS18530	COG2271	Major facilitator Superfamily
B21_RS18535	COG3851	Histidine kinase
B21_RS18540	COG2197	response regulator
B21_RS18545	COG0440	acetolactate synthase activity
B21_RS18550	COG0028	Belongs to the TPP enzyme family
B21_RS18575	COG2814	Major facilitator Superfamily
B21_RS18580	COG0641	radical SAM
B21_RS18590	COG2149	membrane
B21_RS18600	COG3119	arylsulfatase activity
B21_RS18605	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B21_RS18610	COG2207	Transcriptional regulator
B21_RS18650	COG5645	(Lipo)protein
B21_RS18655	COG0823	Involved in the tonB-independent uptake of proteins
B21_RS18665	COG2271	Major facilitator Superfamily
B21_RS18675	COG0800	Aldolase
B21_RS18680	COG3734	2-keto-3-deoxy-galactonokinase
B21_RS18685	COG2186	Transcriptional regulator
B21_RS18695	COG0561	phosphatase activity
B21_RS18700	COG3753	Protein conserved in bacteria
B21_RS18710	COG0187	DNA topoisomerase II activity
B21_RS18720	COG0592	DNA-directed DNA polymerase activity
B21_RS18765	COG0814	amino acid
B21_RS18780	COG2091	lysine biosynthetic process via aminoadipic acid
B21_RS18785	COG0431	NADPH-dependent FMN reductase
B21_RS18790	COG2252	PERMEase
B21_RS18795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B21_RS18805	COG3196	Protein conserved in bacteria
B21_RS18810	COG0363	glucosamine-6-phosphate deaminase activity
B21_RS18815	COG2382	esterase
B21_RS18825	COG2723	6-phospho-beta-galactosidase activity
B21_RS18830	COG1263	PTS System
B21_RS18830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B21_RS18830	COG2190	(PTS) system
B21_RS18835	COG3711	transcriptional antiterminator
B21_RS18840	COG0704	Plays a role in the regulation of phosphate uptake
B21_RS18845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B21_RS18850	COG0581	inorganic phosphate transmembrane transporter activity
B21_RS18855	COG0573	inorganic phosphate transmembrane transporter activity
B21_RS18860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B21_RS18865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B21_RS18915	COG3312	ion transport
B21_RS18930	COG0716	FMN binding
B21_RS18935	COG1522	sequence-specific DNA binding
B21_RS18965	COG2801	Transposase and inactivated derivatives
B21_RS18970	COG2963	transposase activity
B21_RS18980	COG1129	ABC transporter
B21_RS18985	COG1172	Belongs to the binding-protein-dependent transport system permease family
B21_RS18990	COG1879	ABC-type sugar transport system periplasmic component
B21_RS18995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B21_RS19000	COG1609	Transcriptional regulator
B21_RS19005	COG0477	Major facilitator Superfamily
B21_RS19010	COG2186	Transcriptional regulator
B21_RS19050	COG3085	chromosome segregation
B21_RS19055	COG0606	chelatase, subunit chli
B21_RS19070	COG3978	acetolactate synthase activity
B21_RS19075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B21_RS19085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B21_RS19090	COG0583	DNA-binding transcription factor activity
B21_RS19100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B21_RS19110	COG0210	DNA helicase
B21_RS19125	COG3118	belongs to the thioredoxin family
B21_RS19135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B21_RS19145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B21_RS19150	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
B21_RS19155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B21_RS19160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B21_RS19165	COG1088	dTDP-glucose 4,6-dehydratase activity
B21_RS19170	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B21_RS19175	COG0456	acetyltransferase
B21_RS19180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B21_RS19185	COG2244	polysaccharide biosynthetic process
B21_RS19205	COG1113	amino acid transport
B21_RS19230	COG0641	radical SAM
B21_RS19235	COG3119	arylsulfatase activity
B21_RS19240	COG3071	HemY protein
B21_RS19245	COG2959	enzyme of heme biosynthesis
B21_RS19250	COG1587	Uroporphyrinogen-III synthase
B21_RS19260	COG3072	Adenylate cyclase
B21_RS19270	COG5567	small periplasmic lipoprotein
B21_RS19280	COG3159	Protein conserved in bacteria
B21_RS19290	COG1011	Hydrolase
B21_RS19295	COG0210	DNA helicase
B21_RS19300	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
B21_RS19305	COG3698	Phosphodiester glycosidase
B21_RS19315	COG0598	Magnesium transport protein CorA
B21_RS19345	COG2962	Rard protein
B21_RS19350	COG2050	protein possibly involved in aromatic compounds catabolism
B21_RS19355	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
B21_RS19360	COG0514	ATP-dependent DNA helicase (RecQ)
B21_RS19365	COG1280	lysine exporter protein (LysE YggA)
B21_RS19370	COG1280	lysine exporter protein (LysE YggA)
B21_RS19375	COG2267	carboxylic ester hydrolase activity
B21_RS19380	COG0561	phosphatase activity
B21_RS19385	COG0697	spore germination
B21_RS19390	COG0583	DNA-binding transcription factor activity
B21_RS19395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B21_RS19400	COG0583	DNA-binding transcription factor activity
B21_RS19405	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B21_RS19415	COG0549	Belongs to the carbamate kinase family
B21_RS19420	COG1304	FMN binding
B21_RS19425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B21_RS19435	COG1335	isochorismatase
B21_RS19445	COG0412	Dienelactone hydrolase
B21_RS19450	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B21_RS19470	COG0800	Aldolase
B21_RS19475	COG3734	2-keto-3-deoxy-galactonokinase
B21_RS19480	COG1414	Transcriptional regulator
B21_RS19485	COG1322	Protein conserved in bacteria
B21_RS19495	COG3165	ubiquinone biosynthetic process from chorismate
B21_RS19505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B21_RS19510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B21_RS19515	COG0805	protein transport
B21_RS19520	COG0084	hydrolase, TatD family'
B21_RS19525	COG0250	Participates in transcription elongation, termination and antitermination
B21_RS19530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B21_RS19535	COG0543	2 iron, 2 sulfur cluster binding
B21_RS19555	COG1739	Uncharacterized protein family UPF0029
B21_RS19560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B21_RS19565	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
B21_RS19595	COG1763	Mo-molybdopterin cofactor biosynthetic process
B21_RS19600	COG0746	molybdenum cofactor guanylyltransferase activity
B21_RS19605	COG3084	Protein conserved in bacteria
B21_RS19610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B21_RS19615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B21_RS19620	COG5339	Protein conserved in bacteria
B21_RS19625	COG0204	Acyl-transferase
B21_RS19635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B21_RS19635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B21_RS19650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B21_RS19660	COG2204	response regulator
B21_RS19665	COG3852	Histidine kinase
B21_RS19670	COG0174	glutamine synthetase
B21_RS19680	COG1217	gtp-binding protein TYPA
B21_RS19685	COG2188	Transcriptional regulator
B21_RS19690	COG1082	Xylose isomerase domain protein TIM barrel
B21_RS19695	COG2271	Major facilitator Superfamily
B21_RS19700	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B21_RS19705	COG2211	Major facilitator Superfamily
B21_RS19710	COG2211	Major facilitator Superfamily
B21_RS19715	COG1501	Belongs to the glycosyl hydrolase 31 family
B21_RS19720	COG2017	converts alpha-aldose to the beta-anomer
B21_RS19725	COG2942	2-epimerase
B21_RS19730	COG3684	Belongs to the aldolase LacD family
B21_RS19735	COG2084	Dehydrogenase
B21_RS19740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B21_RS19745	COG1349	DNA-binding transcription factor activity
B21_RS19750	COG1011	Hydrolase
B21_RS19765	COG0456	acetyltransferase
B21_RS19770	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B21_RS19775	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B21_RS19790	COG2864	formate dehydrogenase
B21_RS19795	COG0437	4 iron, 4 sulfur cluster binding
B21_RS19800	COG0243	molybdopterin cofactor binding
B21_RS19800	COG3383	formate dehydrogenase (NAD+) activity
B21_RS19805	COG0243	molybdopterin cofactor binding
B21_RS19805	COG3383	formate dehydrogenase (NAD+) activity
B21_RS19820	COG3711	transcriptional antiterminator
B21_RS19820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS19825	COG1363	Peptidase, m42
B21_RS19830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS19830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS19835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS19885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B21_RS19900	COG2258	MOSC domain
B21_RS19905	COG2205	protein histidine kinase activity
B21_RS19910	COG0745	RESPONSE REGULATOR receiver
B21_RS19915	COG3678	ATP-independent chaperone mediated protein folding
B21_RS19935	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B21_RS19955	COG3152	Membrane
B21_RS19960	COG3691	Protein conserved in bacteria
B21_RS19965	COG0589	response to stress
B21_RS19975	COG1494	fructose-1,6-bisphosphatase
B21_RS19985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B21_RS20000	COG1575	Belongs to the MenA family. Type 1 subfamily
B21_RS20015	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B21_RS20020	COG1609	Transcriptional regulator
B21_RS20025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B21_RS20040	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
B21_RS20050	COG0626	cystathionine gamma-synthase activity
B21_RS20055	COG0527	aspartate kinase activity
B21_RS20055	COG0460	homoserine dehydrogenase
B21_RS20065	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B21_RS20075	COG0697	spore germination
B21_RS20080	COG3738	Protein conserved in bacteria
B21_RS20090	COG0371	Dehydrogenase
B21_RS20095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B21_RS20100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS20100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B21_RS20100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS20105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS20110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS20115	COG1882	Formate acetyltransferase
B21_RS20120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B21_RS20125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B21_RS20130	COG2207	Transcriptional regulator
B21_RS20135	COG2194	sulfuric ester hydrolase activity
B21_RS20150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B21_RS20165	COG0583	DNA-binding transcription factor activity
B21_RS20225	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B21_RS20225	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B21_RS20265	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B21_RS20270	COG0250	Participates in transcription elongation, termination and antitermination
B21_RS20310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B21_RS20320	COG2104	thiamine diphosphate biosynthetic process
B21_RS20325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B21_RS20360	COG3068	Protein conserved in bacteria
B21_RS20375	COG3678	ATP-independent chaperone mediated protein folding
B21_RS20380	COG4191	Histidine kinase
B21_RS20385	COG2204	response regulator
B21_RS20390	COG0151	Belongs to the GarS family
B21_RS20420	COG0456	acetyltransferase
B21_RS20430	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B21_RS20435	COG2224	Isocitrate lyase
B21_RS20455	COG1414	Transcriptional regulator
B21_RS20460	COG1410	methionine synthase
B21_RS20460	COG0646	methionine synthase
B21_RS20465	COG1283	sodium-dependent phosphate transmembrane transporter activity
B21_RS20475	COG1187	pseudouridine synthase activity
B21_RS20485	COG0527	aspartate kinase activity
B21_RS20510	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B21_RS20535	COG0477	Major facilitator Superfamily
B21_RS20535	COG2814	Major facilitator Superfamily
B21_RS20540	COG3833	ABC-type maltose transport systems, permease component
B21_RS20545	COG1175	transmembrane transport
B21_RS20550	COG2182	Extracellular solute-binding protein
B21_RS20560	COG3842	ATPase activity
B21_RS20580	COG1357	PFAM Pentapeptide repeats (8 copies)
B21_RS20600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B21_RS20610	COG0534	Mate efflux family protein
B21_RS20615	COG3237	CsbD-like
B21_RS20620	COG0735	belongs to the Fur family
B21_RS20635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B21_RS20645	COG0604	alcohol dehydrogenase
B21_RS20650	COG0305	Participates in initiation and elongation during chromosome replication
B21_RS20655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B21_RS20660	COG1448	Aminotransferase
B21_RS20670	COG3700	Belongs to the class B bacterial acid phosphatase family
B21_RS20675	COG0432	Pfam Uncharacterised protein family UPF0047
B21_RS20680	COG2315	Protein conserved in bacteria
B21_RS20685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B21_RS20690	COG0629	single-stranded DNA binding
B21_RS20700	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B21_RS20705	COG2207	Transcriptional regulator
B21_RS20710	COG0789	Transcriptional regulator
B21_RS20715	COG2252	PERMEase
B21_RS20720	COG0025	NhaP-type Na H and K H
B21_RS20735	COG3162	membrane
B21_RS20740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B21_RS20750	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
B21_RS20755	COG0437	4 iron, 4 sulfur cluster binding
B21_RS20760	COG3301	Polysulphide reductase, NrfD
B21_RS20765	COG1138	Cytochrome C-type biogenesis protein
B21_RS20770	COG3088	subunit of a heme lyase
B21_RS20775	COG4235	cytochrome complex assembly
B21_RS20780	COG1301	dicarboxylic acid transport
B21_RS20785	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B21_RS20790	COG3383	formate dehydrogenase (NAD+) activity
B21_RS20795	COG3383	formate dehydrogenase (NAD+) activity
B21_RS20800	COG1538	Outer membrane efflux protein
B21_RS20805	COG1289	transmembrane transporter activity
B21_RS20810	COG1566	PFAM secretion protein HlyD family protein
B21_RS20820	COG2015	COG2015, Alkyl sulfatase and related hydrolases
B21_RS20825	COG1940	carbohydrate kinase activity
B21_RS20830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B21_RS20835	COG1172	Belongs to the binding-protein-dependent transport system permease family
B21_RS20840	COG1129	ABC transporter
B21_RS20845	COG1879	ABC-type sugar transport system periplasmic component
B21_RS20850	COG1737	Transcriptional regulator
B21_RS20855	COG0698	ribose 5-phosphate isomerase
B21_RS20865	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B21_RS20870	COG0456	acetyltransferase
B21_RS20875	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
B21_RS20880	COG3454	Phosphonate metabolism
B21_RS20885	COG4778	phosphonate C-P lyase system protein PhnL
B21_RS20890	COG4107	phosphonate C-P lyase system protein PhnK
B21_RS20895	COG3627	carbon phosphorus lyase activity
B21_RS20900	COG3626	phosphonate metabolism
B21_RS20905	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
B21_RS20910	COG3624	Phosphonate C-P lyase system protein PhnG
B21_RS20915	COG2188	Transcriptional regulator
B21_RS20920	COG3639	organic phosphonate transmembrane transporter activity
B21_RS20925	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B21_RS20935	COG2764	glyoxalase bleomycin resistance protein dioxygenase
B21_RS20940	COG2824	Alkylphosphonate utilization operon protein PhnA
B21_RS20955	COG0477	Major facilitator Superfamily
B21_RS20965	COG0642	Histidine kinase
B21_RS20970	COG0745	RESPONSE REGULATOR receiver
B21_RS20975	COG2194	sulfuric ester hydrolase activity
B21_RS20980	COG0531	amino acid
B21_RS20985	COG2207	Transcriptional regulator
B21_RS20990	COG1982	Orn Lys Arg decarboxylase major
B21_RS20995	COG2169	Transcriptional regulator
B21_RS21005	COG1486	melibiose metabolic process
B21_RS21010	COG2211	Major facilitator Superfamily
B21_RS21015	COG3647	Membrane
B21_RS21020	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B21_RS21020	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B21_RS21025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B21_RS21035	COG4565	transcriptional regulatory protein
B21_RS21045	COG3592	Divergent 4Fe-4S mono-cluster
B21_RS21050	COG2388	GCN5-related N-acetyl-transferase
B21_RS21065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B21_RS21070	COG3104	oligopeptide transport
B21_RS21075	COG1982	Orn Lys Arg decarboxylase major
B21_RS21080	COG0531	amino acid
B21_RS21085	COG3710	Transcriptional regulator
B21_RS21095	COG1309	transcriptional regulator
B21_RS21110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B21_RS21115	COG1027	Aspartate ammonia-lyase
B21_RS21120	COG3030	protein affecting phage T7 exclusion by the F plasmid
B21_RS21125	COG0531	amino acid
B21_RS21150	COG1509	lysine 2,3-aminomutase activity
B21_RS21160	COG5510	response to toxic substance
B21_RS21165	COG5510	response to toxic substance
B21_RS21170	COG2076	Multidrug Resistance protein
B21_RS21175	COG3040	lipid binding
B21_RS21180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B21_RS21195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B21_RS21200	COG1053	succinate dehydrogenase
B21_RS21210	COG0531	amino acid
B21_RS21215	COG1511	domain protein
B21_RS21215	COG3264	Mechanosensitive ion channel
B21_RS21250	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B21_RS21255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B21_RS21255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B21_RS21260	COG0802	atpase or kinase
B21_RS21265	COG0860	N-Acetylmuramoyl-L-alanine amidase
B21_RS21285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B21_RS21290	COG0330	HflC and HflK could
B21_RS21295	COG0330	HflC and HflK could
B21_RS21300	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
B21_RS21315	COG0557	exoribonuclease II activity
B21_RS21320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B21_RS21325	COG3789	protein conserved in bacteria
B21_RS21330	COG1842	Phage shock protein A
B21_RS21340	COG3766	membrane
B21_RS21345	COG5463	Belongs to the UPF0441 family
B21_RS21350	COG0754	glutathionylspermidine amidase activity
B21_RS21355	COG1960	acyl-CoA dehydrogenase activity
B21_RS21365	COG3650	response to hydrogen peroxide
B21_RS21370	COG1073	alpha beta
B21_RS21385	COG3037	sugar-specific permease SgaT UlaA
B21_RS21390	COG3414	Phosphotransferase system galactitol-specific IIB component
B21_RS21435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B21_RS21445	COG2271	Major facilitator Superfamily
B21_RS21450	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B21_RS21455	COG4670	ketone body catabolic process
B21_RS21460	COG1024	Enoyl-CoA hydratase
B21_RS21470	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS21475	COG1309	transcriptional regulator
B21_RS21480	COG3061	Opacity-associated protein A
B21_RS21485	COG0545	Peptidyl-prolyl cis-trans isomerase
B21_RS21490	COG1113	amino acid transport
B21_RS21500	COG0697	spore germination
B21_RS21505	COG0702	epimerase
B21_RS21510	COG1733	regulation of RNA biosynthetic process
B21_RS21515	COG0737	Belongs to the 5'-nucleotidase family
B21_RS21520	COG1218	3'(2'),5'-bisphosphate nucleotidase
B21_RS21525	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
B21_RS21535	COG1253	flavin adenine dinucleotide binding
B21_RS21550	COG0729	surface antigen
B21_RS21555	COG2911	Protein conserved in bacteria
B21_RS21560	COG2105	PFAM AIG2 family protein
B21_RS21565	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B21_RS21570	COG1879	ABC-type sugar transport system periplasmic component
B21_RS21575	COG1129	ABC transporter
B21_RS21580	COG1172	Belongs to the binding-protein-dependent transport system permease family
B21_RS21585	COG1172	Belongs to the binding-protein-dependent transport system permease family
B21_RS21595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B21_RS21605	COG0312	modulator of DNA gyrase
B21_RS21610	COG3783	Cytochrome b(562)
B21_RS21615	COG0602	queuosine metabolic process
B21_RS21620	COG1328	CTP reductase activity
B21_RS21625	COG0366	Alpha amylase catalytic
B21_RS21630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B21_RS21630	COG1263	PTS System
B21_RS21635	COG1609	Transcriptional regulator
B21_RS21640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B21_RS21645	COG0251	oxidation-reduction process
B21_RS21670	COG0251	oxidation-reduction process
B21_RS21675	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS21680	COG1309	transcriptional regulator
B21_RS21685	COG2731	YhcH YjgK YiaL family protein
B21_RS21700	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
B21_RS21705	COG0456	acetyltransferase
B21_RS21710	COG4269	membrane
B21_RS21720	COG2927	DNA polymerase III (CHI subunit)
B21_RS21730	COG0795	lipopolysaccharide-transporting ATPase activity
B21_RS21735	COG0795	lipopolysaccharide-transporting ATPase activity
B21_RS21740	COG0433	COG0433 Predicted ATPase
B21_RS21745	COG1609	Transcriptional regulator
B21_RS21750	COG2610	gluconate transmembrane transporter activity
B21_RS21755	COG1028	Short-chain dehydrogenase reductase Sdr
B21_RS21760	COG1063	alcohol dehydrogenase
B21_RS21765	COG3265	gluconokinase activity
B21_RS21770	COG1064	alcohol dehydrogenase
B21_RS21780	COG0582	viral genome integration into host DNA
B21_RS21810	COG3385	transposase activity
B21_RS21815	COG2814	Major facilitator Superfamily
B21_RS21820	COG0673	inositol 2-dehydrogenase activity
B21_RS21850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B21_RS21875	COG2085	NADP oxidoreductase coenzyme F420-dependent
B21_RS21880	COG1120	ATPase activity
B21_RS21885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B21_RS21890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B21_RS21895	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B21_RS21900	COG4772	TonB-dependent receptor
B21_RS21905	COG3712	iron ion homeostasis
B21_RS21910	COG1595	DNA-templated transcription, initiation
B21_RS21945	COG1349	DNA-binding transcription factor activity
B21_RS21950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B21_RS21955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B21_RS21960	COG0434	BtpA family
B21_RS21965	COG3775	system Galactitol-specific IIC component
B21_RS21970	COG3414	Phosphotransferase system galactitol-specific IIB component
B21_RS21975	COG1363	Peptidase, m42
B21_RS21980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B21_RS21985	COG3153	acetyltransferase
B21_RS22015	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
B21_RS22020	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B21_RS22035	COG0582	viral genome integration into host DNA
B21_RS22045	COG4974	Belongs to the 'phage' integrase family
B21_RS22055	COG3539	Fimbrial protein
B21_RS22060	COG3539	Fimbrial protein
B21_RS22065	COG3121	Chaperone
B21_RS22070	COG3188	usher protein
B21_RS22075	COG3539	Fimbrial protein
B21_RS22080	COG3539	Fimbrial protein
B21_RS22085	COG3539	Fimbrial protein
B21_RS22090	COG2610	gluconate transmembrane transporter activity
B21_RS22105	COG0246	Mannitol dehydrogenase
B21_RS22115	COG2186	Transcriptional regulator
B21_RS22140	COG0583	DNA-binding transcription factor activity
B21_RS22145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B21_RS22150	COG0700	Nucleoside recognition
B21_RS22155	COG3366	ferrous iron transmembrane transporter activity
B21_RS22165	COG0477	Major facilitator Superfamily
B21_RS22170	COG3204	pilus organization
B21_RS22180	COG1924	4 iron, 4 sulfur cluster binding
B21_RS22185	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
B21_RS22190	COG2733	membrane
B21_RS22195	COG2814	Major facilitator Superfamily
B21_RS22215	COG4268	DNA restriction-modification system
B21_RS22220	COG1401	restriction endodeoxyribonuclease activity
B21_RS22235	COG1662	PFAM IS1 transposase
B21_RS22245	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B21_RS22250	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B21_RS22255	COG1715	Restriction endonuclease
B21_RS22260	COG0523	cobalamin synthesis protein
B21_RS22265	COG2879	small protein
B21_RS22270	COG1966	Carbon starvation protein
B21_RS22280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B21_RS22285	COG2368	4-hydroxyphenylacetate
B21_RS22305	COG3971	2-oxopent-4-enoate hydratase activity
B21_RS22315	COG3384	dioxygenase
B21_RS22320	COG1012	belongs to the aldehyde dehydrogenase family
B21_RS22325	COG0179	Fumarylacetoacetate (FAA) hydrolase
B21_RS22330	COG1846	Transcriptional regulator
B21_RS22335	COG0840	transmembrane signaling receptor activity
B21_RS22340	COG2271	Major facilitator Superfamily
B21_RS22350	COG1063	alcohol dehydrogenase
B21_RS22365	COG1484	DNA-dependent DNA replication
B21_RS22380	COG2966	Psort location CytoplasmicMembrane, score
B21_RS22385	COG2197	response regulator
B21_RS22390	COG2197	response regulator
B21_RS22395	COG4114	ferric iron reductase
B21_RS22425	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
B21_RS22430	COG0456	acetyltransferase
B21_RS22435	COG1011	Hydrolase
B21_RS22445	COG2823	Periplasmic or secreted lipoprotein
B21_RS22455	COG4667	esterase of the alpha-beta hydrolase superfamily
B21_RS22460	COG0084	hydrolase, TatD family'
B21_RS22465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B21_RS22470	COG1328	CTP reductase activity
B21_RS22510	COG3726	membrane protein affecting hemolysin expression
B21_RS22515	COG0560	Phosphoserine phosphatase
B21_RS22520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B21_RS22525	COG1056	cytidyltransferase-related domain
B21_RS22525	COG3172	ATPase kinase involved in NAD metabolism
B21_RS22535	COG0488	(ABC) transporter
B21_RS22540	COG0741	lytic transglycosylase activity
B21_RS22560	COG2207	Transcriptional regulator
B21_RS22560	COG3708	Transcriptional regulator
B21_RS22565	COG3045	CreA protein
B21_RS22570	COG0745	RESPONSE REGULATOR receiver
B21_RS22575	COG2205	protein histidine kinase activity
B21_RS22580	COG4452	Inner membrane protein CreD
B21_RS22585	COG0745	RESPONSE REGULATOR receiver
B21_RS22595	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA