locus-tag class description HPM97_RS00005 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HPM97_RS00010 ENOG4107ZSV Receptor HPM97_RS00015 ENOG4105TNG K13735 adhesin invasin HPM97_RS00030 ENOG4105CSH Transporter HPM97_RS00035 ENOG4105FYV Amp nucleosidase HPM97_RS00040 ENOG4105CDY transcriptional regulatory protein HPM97_RS00050 ENOG4105UQX Mate efflux family protein HPM97_RS00060 ENOG4107R11 Transcriptional regulator HPM97_RS00065 ENOG4106P55 Transcriptional regulator HPM97_RS00075 ENOG4108PXI ErfK YbiS YcfS YnhG HPM97_RS00090 ENOG4108YZT Adenosylcobinamide kinase HPM97_RS00100 ENOG4105GTN ParB Domain Protein Nuclease HPM97_RS00105 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HPM97_RS00120 ENOG4105CH7 arginosuccinase HPM97_RS00125 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM97_RS00130 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM97_RS00135 ENOG4105JXH GntR family transcriptional regulator HPM97_RS00140 ENOG4108MRH transcriptional regulatory protein HPM97_RS00145 ENOG4105HDK L-asparaginase HPM97_RS00150 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM97_RS00160 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HPM97_RS00165 ENOG4105CEE C4-dicarboxylate transporter HPM97_RS00180 ENOG4105D44 asparaginase HPM97_RS00200 ENOG4105KT7 mgtC SapB transporter HPM97_RS00210 ENOG4105ETE Transcriptional regulator (LacI family HPM97_RS00240 ENOG4105EMF GntR family transcriptional regulator HPM97_RS00245 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HPM97_RS00250 ENOG4108RTU Aldolase HPM97_RS00260 ENOG4105DJB Major Facilitator Superfamily HPM97_RS00270 ENOG4107YNJ LysR family Transcriptional regulator HPM97_RS00280 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM97_RS00300 ENOG4108RVA ribokinase HPM97_RS00315 ENOG41080QX K07048 phosphotriesterase-related protein HPM97_RS00380 ENOG4108F5E vimentin HPM97_RS00385 ENOG4108YIV HPM97_RS00405 ENOG4106H6R UPF0380 protein HPM97_RS00410 ENOG4105MFG Antirestriction protein HPM97_RS00415 ENOG4108YGG dna repair protein HPM97_RS00425 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HPM97_RS00460 ENOG4105DR8 Membrane HPM97_RS00470 ENOG4105DZ1 carboxypeptidase HPM97_RS00475 ENOG4105CJB Exodeoxyribonuclease I HPM97_RS00485 ENOG4105CUC YeeE YedE family protein HPM97_RS00490 ENOG4105CUB amino acid HPM97_RS00500 ENOG4105EQ1 Transcriptional regulator HPM97_RS00505 ENOG4107SRH Nad-dependent epimerase dehydratase HPM97_RS00520 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HPM97_RS00530 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HPM97_RS00535 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HPM97_RS00555 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HPM97_RS00560 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPM97_RS00565 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HPM97_RS00570 ENOG4107QKV phosphomannomutase HPM97_RS00585 ENOG4105FGF GDP-mannose mannosyl hydrolase HPM97_RS00590 ENOG4105C30 Nad-dependent epimerase dehydratase HPM97_RS00595 ENOG4105C0K Gdp-mannose 4,6-dehydratase HPM97_RS00605 ENOG4105CMR udp-glucose 4-epimerase HPM97_RS00610 ENOG4107XU6 Glycosyl transferase (Group 1 HPM97_RS00620 ENOG4105ECJ Glycosyl Transferase HPM97_RS00625 ENOG4105ER6 polysaccharide biosynthesis protein HPM97_RS00630 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPM97_RS00635 ENOG4105DMT epimerase dehydratase HPM97_RS00640 ENOG4105G1A colanic acid biosynthesis protein HPM97_RS00645 ENOG4107T8Q Glycosyl transferase (Group 1 HPM97_RS00650 ENOG4105C74 pyruvyl transferase HPM97_RS00655 ENOG4105PSV Polysaccharide Biosynthesis Protein HPM97_RS00660 ENOG4105D3Q Sugar transferase HPM97_RS00665 ENOG4107QKV phosphomannomutase HPM97_RS00670 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HPM97_RS00675 ENOG4106CD9 glycosyl transferase group 1 HPM97_RS00680 ENOG4105FGF GDP-mannose mannosyl hydrolase HPM97_RS00685 ENOG4105C30 Nad-dependent epimerase dehydratase HPM97_RS00690 ENOG4105C0K Gdp-mannose 4,6-dehydratase HPM97_RS00695 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HPM97_RS00700 ENOG4105ECJ Glycosyl Transferase HPM97_RS00705 ENOG4108NYJ Colanic acid HPM97_RS00710 ENOG4107RXY Glycosyl transferase HPM97_RS00715 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HPM97_RS00720 ENOG41090RK glycosyl transferase HPM97_RS00725 ENOG4105D75 Capsular exopolysaccharide family HPM97_RS00730 ENOG4105KJF protein tyrosine phosphatase HPM97_RS00735 ENOG4105DAY polysaccharide export protein HPM97_RS00745 ENOG4105EE5 Membrane protein terC HPM97_RS00760 ENOG4108GAE asmA family HPM97_RS00770 ENOG4105DBI uridine monophosphokinase HPM97_RS00775 ENOG4105BZU Histidine kinase HPM97_RS00780 ENOG4105D03 DNA-3-methyladenine glycosylase II HPM97_RS00785 ENOG4105R8A Heat shock protein HPM97_RS00790 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HPM97_RS00795 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HPM97_RS00800 ENOG4108M24 von Willebrand factor, type A HPM97_RS00850 ENOG4105EB3 Histidine kinase HPM97_RS00855 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPM97_RS00860 ENOG4105KWI UPF0339 protein HPM97_RS00865 ENOG4105X54 addiction module antidote protein HPM97_RS00875 ENOG4105CFP Peptidase U32 HPM97_RS00880 ENOG41076Z6 Uncharacterized protein yegR HPM97_RS00895 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HPM97_RS00900 ENOG4105DT3 PTS system, galactitol-specific IIc component HPM97_RS00905 ENOG41090UW PTS System HPM97_RS00910 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HPM97_RS00920 ENOG4105D2N Aldolase HPM97_RS00925 ENOG4105EIE fructose-bisphosphate aldolase HPM97_RS00930 ENOG4105EAA nucleoside HPM97_RS00935 ENOG4108KD5 ADP-ribosylation crystallin J1 HPM97_RS00940 ENOG4108TFM Kinase, PfkB family HPM97_RS00945 ENOG4105FDP GntR family transcriptional regulator HPM97_RS00950 ENOG4108UQ1 hydrolase, family 25 HPM97_RS00955 ENOG4105DWF phosphomethylpyrimidine kinase HPM97_RS01015 ENOG41061MD high-affinity nickel-transporter HPM97_RS01020 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HPM97_RS01025 ENOG410662B Type-1 fimbrial protein HPM97_RS01030 ENOG4105CW0 outer membrane usher protein HPM97_RS01035 ENOG4108MQF Chaperone HPM97_RS01040 ENOG41063W2 Fimbrial protein HPM97_RS01045 ENOG41067AK Protein of unknown function (DUF2574) HPM97_RS01050 ENOG4105D1F ATP-binding protein HPM97_RS01060 ENOG4108KDT Molybdate metabolism regulator HPM97_RS01065 ENOG4108KDT Molybdate metabolism regulator HPM97_RS01070 ENOG4108KDT Molybdate metabolism regulator HPM97_RS01080 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HPM97_RS01085 ENOG4105RD5 HPM97_RS01090 ENOG4105DEG Vwa containing coxe family protein HPM97_RS01095 ENOG410903U zinc ion binding HPM97_RS01100 ENOG4108YCW (LipO)protein HPM97_RS01105 ENOG4108W15 Protein of unknown function (DUF1456) HPM97_RS01110 ENOG4108NEV two component transcriptional regulator, LytTR family HPM97_RS01115 ENOG4108HRK Histidine kinase HPM97_RS01120 ENOG4108XDN Transcriptional regulator HPM97_RS01130 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HPM97_RS01135 ENOG4108IJ8 ABC transporter HPM97_RS01140 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HPM97_RS01145 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HPM97_RS01150 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HPM97_RS01155 ENOG4105CXG d-lactate dehydrogenase HPM97_RS01160 ENOG41061WM D-Alanyl-D-Alanine HPM97_RS01165 ENOG41069YE inner membrane protein yohC HPM97_RS01170 ENOG4105KHU inner membrane protein YohD HPM97_RS01175 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HPM97_RS01180 ENOG4105ETP RND efflux system, outer membrane lipoprotein HPM97_RS01190 ENOG4105EQR Transposase IS116 IS110 IS902 HPM97_RS01195 ENOG4105DWU Membrane HPM97_RS01200 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HPM97_RS01205 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HPM97_RS01210 ENOG4105C7K acetolactate synthase HPM97_RS01215 ENOG4105C5W Aldolase HPM97_RS01220 ENOG4105CGD Nad-dependent epimerase dehydratase HPM97_RS01225 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HPM97_RS01230 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HPM97_RS01245 ENOG41064MM (LipO)protein HPM97_RS01250 ENOG4105E5Z arginine transporter ATP-binding subunit HPM97_RS01255 ENOG4106PMH Extracellular solute-binding protein family 3 HPM97_RS01260 ENOG4105GBT ABC transporter HPM97_RS01265 ENOG4105DMR ABC, transporter HPM97_RS01270 ENOG4106TNF Periplasmic binding protein HPM97_RS01280 ENOG4105RBQ inner membrane protein ybjO HPM97_RS01285 ENOG4105D38 putrescine abc transporter HPM97_RS01290 ENOG4105F38 ABC transporter, permease HPM97_RS01295 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPM97_RS01300 ENOG4107RUE extracellular solute-binding protein family 1 HPM97_RS01305 ENOG4108RMJ sensory transduction regulator HPM97_RS01315 ENOG4108DBC nitroreductase HPM97_RS01320 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HPM97_RS01325 ENOG41090BQ Glutaredoxin HPM97_RS01340 ENOG4108RFG Tetr family transcriptional regulator HPM97_RS01345 ENOG4106UW1 Major Facilitator superfamily HPM97_RS01350 ENOG4108HCJ Hydrolase HPM97_RS01360 ENOG4107QF7 multi-drug HPM97_RS01365 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPM97_RS01370 ENOG4107FB0 transcriptional regulator DeoR family HPM97_RS01375 ENOG4105DZ1 carboxypeptidase HPM97_RS01380 ENOG4108TGY Glutathione S-transferase HPM97_RS01385 ENOG4105D8V Glucose sorbosone dehydrogenase HPM97_RS01390 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HPM97_RS01410 ENOG41064RH membrane protein YliF HPM97_RS01415 ENOG4105BZU Histidine kinase HPM97_RS01430 ENOG4105DEF Extracellular solute-binding protein, family 5 HPM97_RS01435 ENOG4108JQ6 ABC transporter HPM97_RS01440 ENOG4105D44 asparaginase HPM97_RS01445 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPM97_RS01450 ENOG4105D06 uba thif-type nad fad binding protein HPM97_RS01455 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPM97_RS01460 ENOG4105F1A Pyruvate formate-lyase HPM97_RS01470 ENOG4108HCJ Hydrolase HPM97_RS01475 ENOG41072TH Protein of unknown function (DUF1479) HPM97_RS01485 ENOG4105C5H ABC transporter HPM97_RS01490 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPM97_RS01495 ENOG4105F4P )-transporter HPM97_RS01500 ENOG4105KST dependent repressor HPM97_RS01510 ENOG4108I6E Sulfatase HPM97_RS01515 ENOG4108T1M outer membrane protein x HPM97_RS01525 ENOG4107AQZ Membrane HPM97_RS01535 ENOG4107R0W ABC transporter HPM97_RS01540 ENOG4105E5Q amino acid AbC transporter HPM97_RS01545 ENOG4105CDA abc transporter atp-binding protein HPM97_RS01550 ENOG4105D8X mechanosensitive ion channel HPM97_RS01560 ENOG4105ZY9 UPF0379 protein ybiM HPM97_RS01565 ENOG4108IU3 tonb-dependent siderophore receptor HPM97_RS01575 ENOG4105KSC Transcriptional regulator, TraR DksA family HPM97_RS01580 ENOG4105VR4 UPF0379 protein ybiJ HPM97_RS01585 ENOG4105DG4 malate L-lactate dehydrogenase HPM97_RS01590 ENOG4108MTB glycosyl transferase family HPM97_RS01595 ENOG4105DVT helicase HPM97_RS01610 ENOG4105C1J atp-dependent rna helicase HPM97_RS01615 ENOG4107MVR Transcriptional regulator HPM97_RS01625 ENOG4105CJ1 ABC, transporter HPM97_RS01630 ENOG4107QWP ABC-2 type transporter HPM97_RS01635 ENOG4107QWP ABC-2 type transporter HPM97_RS01640 ENOG4105I9U inner membrane protein ybhQ HPM97_RS01645 ENOG4105X23 Endonuclease Exonuclease phosphatase HPM97_RS01650 ENOG4105DZQ phospholipase D Transphosphatidylase HPM97_RS01655 ENOG4107UXM Membrane HPM97_RS01660 ENOG410733J conserved inner membrane protein HPM97_RS01665 ENOG4105HFZ Membrane HPM97_RS01670 ENOG4108ZAF Molybdopterin HPM97_RS01675 ENOG4105M00 molybdopterin converting factor, subunit 1 HPM97_RS01685 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPM97_RS01695 ENOG4105CHW UPF0052 protein HPM97_RS01705 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPM97_RS01710 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPM97_RS01725 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPM97_RS01730 ENOG4108V1U phospholipid-binding protein HPM97_RS01735 ENOG4105NBR Pectinesterase HPM97_RS01740 ENOG4107QM5 aconitate hydratase HPM97_RS01745 ENOG4107QPK )-transporter HPM97_RS01750 ENOG4105C7F AcnD-accessory protein PrpF HPM97_RS01755 ENOG4105F04 LysR family Transcriptional regulator HPM97_RS01765 ENOG4108K4B hydrolase HPM97_RS01775 ENOG4105E0C molybdate abc transporter HPM97_RS01780 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPM97_RS01790 ENOG4105F4R Transcriptional regulator mode HPM97_RS01795 ENOG4105DKW ABC transporter HPM97_RS01800 ENOG4105CMR udp-glucose 4-epimerase HPM97_RS01805 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HPM97_RS01815 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HPM97_RS01825 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPM97_RS01830 ENOG4105JND homeobox protein HPM97_RS01835 ENOG4105PGM cation diffusion facilitator family transporter HPM97_RS01840 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HPM97_RS01885 ENOG4105UFD tol-pal system protein YbgF HPM97_RS01890 ENOG4105KCK Peptidoglycan-associated lipoprotein HPM97_RS01900 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HPM97_RS01910 ENOG4105E02 MotA TolQ exbB proton channel HPM97_RS01915 ENOG4107YD3 Thioesterase HPM97_RS01920 ENOG4105KJB cyd operon protein YbgE HPM97_RS01930 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPM97_RS01935 ENOG4105C4M (Ubiquinol oxidase) subunit I HPM97_RS01950 ENOG4107WFU Glutamate mutase subunit sigma HPM97_RS01960 ENOG4105DJI Methylaspartate mutase, E subunit HPM97_RS01985 ENOG4107GFK fumarate HPM97_RS01990 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HPM97_RS01995 ENOG4105ETT transcriptional Regulator, LysR family HPM97_RS02000 ENOG4105C84 Histidine ammonia-lyase HPM97_RS02005 ENOG41088SP formiminoglutamate hydrolase HPM97_RS02010 ENOG4105CI2 imidazolone-5-propionate hydrolase HPM97_RS02015 ENOG41090B9 response to stress HPM97_RS02020 ENOG4105ETS cytosine purines uracil thiamine allantoin HPM97_RS02025 ENOG4105CGP Urocanate hydratase HPM97_RS02035 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HPM97_RS02045 ENOG4105C7S Dehydrogenase HPM97_RS02050 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HPM97_RS02055 ENOG4105E33 succinate dehydrogenase HPM97_RS02060 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HPM97_RS02065 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HPM97_RS02070 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HPM97_RS02080 ENOG4105BZN citrate synthase HPM97_RS02085 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPM97_RS02095 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPM97_RS02100 ENOG4105CTX dehydratase HPM97_RS02110 ENOG4105CHR reductase HPM97_RS02115 ENOG4105CPQ Dehydrogenase HPM97_RS02120 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPM97_RS02125 ENOG41073TP transcriptional regulator HPM97_RS02130 ENOG4108KK1 membrane protein AbrB duplication HPM97_RS02135 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HPM97_RS02145 ENOG4107R7A Allophanate hydrolase subunit 2 HPM97_RS02150 ENOG4105P4J Allophanate hydrolase, subunit 1 HPM97_RS02155 ENOG4107QNR UPF0135 protein HPM97_RS02160 ENOG4105DUX Transporter HPM97_RS02165 ENOG4105CVP deoxyribo-dipyrimidine photolyase HPM97_RS02170 ENOG4107SEY Conserved Protein HPM97_RS02175 ENOG4105XIQ Protein of unknown function (DUF2517) HPM97_RS02200 ENOG4105C08 Histidine kinase HPM97_RS02205 ENOG4105EEX Two component transcriptional regulator (Winged helix family HPM97_RS02215 ENOG4105CXN decarboxylase HPM97_RS02220 ENOG4105D5Q Arginine ornithine antiporter HPM97_RS02225 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HPM97_RS02230 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HPM97_RS02235 ENOG4105EV9 Alpha Beta Hydrolase HPM97_RS02240 ENOG4105NNH LexA regulated protein HPM97_RS02245 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HPM97_RS02255 ENOG41090R7 Ferric uptake HPM97_RS02260 ENOG4105GX6 (LipO)protein HPM97_RS02275 ENOG4105CI1 PTS System HPM97_RS02285 ENOG4105CE4 GlcNAc 6-P deacetylase HPM97_RS02290 ENOG4105E2R ROK family HPM97_RS02295 ENOG4105D4U had-superfamily hydrolase, subfamily iia HPM97_RS02300 ENOG4105CAQ asparagine synthetase HPM97_RS02345 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HPM97_RS02355 ENOG4105C9A Phoh family HPM97_RS02365 ENOG4108JU5 Magnesium and cobalt efflux protein HPM97_RS02370 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HPM97_RS02375 ENOG4107U91 Rhomboid family HPM97_RS02380 ENOG4107RP9 extracellular solute-binding protein, family 3 HPM97_RS02385 ENOG4105EAD ABC transporter HPM97_RS02390 ENOG4105DRP amino acid AbC transporter HPM97_RS02395 ENOG4105CDA abc transporter atp-binding protein HPM97_RS02405 ENOG4105F7F Chaperone HPM97_RS02410 ENOG4105QFC Hsc56 co-chaperone of HscC HPM97_RS02415 ENOG41069CF Protein of unknown function (DUF1266) HPM97_RS02420 ENOG4107JFD Sel1 repeat HPM97_RS02425 ENOG4105QFC Hsc56 co-chaperone of HscC HPM97_RS02430 ENOG41069CF Protein of unknown function (DUF1266) HPM97_RS02435 ENOG4105EUU Sel1 domain protein repeat-containing protein HPM97_RS02440 ENOG4107PAI alpha helical protein HPM97_RS02450 ENOG4108U2H Rare lipoprotein B HPM97_RS02455 ENOG4105DJF DNA polymerase III, delta' subunit HPM97_RS02465 ENOG4108TGR phosphatase HPM97_RS02470 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HPM97_RS02480 ENOG4105CJN penicillin-binding protein HPM97_RS02485 ENOG4105CNI cell division protein FtsW HPM97_RS02490 ENOG4105K6T rare lipoprotein A HPM97_RS02495 ENOG4105DZ1 carboxypeptidase HPM97_RS02510 ENOG41064T2 transcriptional regulator, lysR family HPM97_RS02520 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HPM97_RS02540 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HPM97_RS02545 ENOG4105CEE C4-dicarboxylate transporter HPM97_RS02550 ENOG4106YYS transcriptional regulatory protein HPM97_RS02555 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPM97_RS02560 ENOG4105DUA (citrate (pro-3S)-lyase ligase HPM97_RS02570 ENOG4105CI0 Citrate lyase HPM97_RS02575 ENOG4105CHY citrate lyase, alpha HPM97_RS02590 ENOG4107QPK )-transporter HPM97_RS02595 ENOG4105KTS ribonuclease HPM97_RS02600 ENOG4105NXH GreA GreB family elongation factor HPM97_RS02605 ENOG4108U51 Universal stress protein HPM97_RS02610 ENOG4108JU3 Alkyl hydroperoxide reductase HPM97_RS02615 ENOG4105D3R alkyl hydroperoxide reductase HPM97_RS02620 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HPM97_RS02625 ENOG4105DQS Transcriptional regulator HPM97_RS02630 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HPM97_RS02635 ENOG4105GTN ParB Domain Protein Nuclease HPM97_RS02640 ENOG4105CHM Aminotransferase HPM97_RS02645 ENOG4107SCQ Iron-containing alcohol dehydrogenase HPM97_RS02650 ENOG4105VCD cytoplasmic protein HPM97_RS02655 ENOG4105D22 carbon starvation protein HPM97_RS02660 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HPM97_RS02665 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HPM97_RS02670 ENOG4105WQI isochorismatase HPM97_RS02675 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HPM97_RS02680 ENOG4105E4F Isochorismate synthase HPM97_RS02685 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HPM97_RS02695 ENOG4105DQ5 transport system permease protein HPM97_RS02700 ENOG4105TVJ transport system, permease HPM97_RS02705 ENOG4105E0A ABC, transporter HPM97_RS02710 ENOG4108QY5 Ferric enterobactin transport protein HPM97_RS02715 ENOG4105C0W non-ribosomal peptide synthetase HPM97_RS02720 ENOG41085A6 mbth domain-containing protein HPM97_RS02725 ENOG4105E93 esterase HPM97_RS02730 ENOG4107RNH Outer membrane receptor FepA HPM97_RS02735 ENOG4108TSE Transferase HPM97_RS02750 ENOG4105WQ6 Membrane HPM97_RS02755 ENOG4105MSB protein, conserved in bacteria HPM97_RS02760 ENOG4108RCM Nitroreductase HPM97_RS02765 ENOG4105CUY Mechanosensitive ion channel HPM97_RS02770 ENOG4105C85 amino acid HPM97_RS02775 ENOG4108IJF Heavy metal efflux pump, CzcA HPM97_RS02780 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HPM97_RS02785 ENOG410624V efflux system protein HPM97_RS02790 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPM97_RS02795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPM97_RS02800 ENOG4105GR3 Histidine kinase HPM97_RS02805 ENOG410802X bacteriophage n4 adsorption protein b HPM97_RS02810 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HPM97_RS02815 ENOG4105QUW HPM97_RS02830 ENOG4108Q9V regulatoR HPM97_RS02835 ENOG4108ZI2 Fimbrial protein HPM97_RS02840 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HPM97_RS02845 ENOG4105CW0 outer membrane usher protein HPM97_RS02850 ENOG4108AF8 Chaperone HPM97_RS02855 ENOG4108WDE Fimbrial protein HPM97_RS02865 ENOG4105WQ3 Rna-binding protein HPM97_RS02870 ENOG4105S2T inner membrane protein YbcI HPM97_RS02880 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HPM97_RS02890 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HPM97_RS02895 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HPM97_RS02900 ENOG4105C5B carbamate kinase HPM97_RS02905 ENOG4105G5A Protein of unknown function (DUF2877) HPM97_RS02910 ENOG4107REC cytoplasmic protein HPM97_RS02915 ENOG4107R1Q Membrane protein FdrA HPM97_RS02920 ENOG4105DG4 malate L-lactate dehydrogenase HPM97_RS02925 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HPM97_RS02930 ENOG4105S0E allantoin catabolism protein HPM97_RS02935 ENOG4105BZW Glycerate kinase HPM97_RS02940 ENOG4105DTE Xanthine uracil vitamin C permease HPM97_RS02950 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HPM97_RS02955 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPM97_RS02960 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HPM97_RS02965 ENOG41060W2 glyoxylate carboligase HPM97_RS02970 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HPM97_RS02980 ENOG4107653 Transcriptional regulator HPM97_RS02990 ENOG4105CV6 ABC transporter, permease HPM97_RS02995 ENOG4108I0Y (ABC) transporter HPM97_RS03000 ENOG4108UJV acyl-CoA thioesterase i HPM97_RS03005 ENOG4105E1F short-chain dehydrogenase reductase HPM97_RS03010 ENOG4107QR8 Thioredoxin HPM97_RS03015 ENOG4105C4B ABC transporter, permease HPM97_RS03020 ENOG41083J0 (ABC) transporter HPM97_RS03025 ENOG4107QX8 SPFH domain, Band 7 family protein HPM97_RS03030 ENOG4105G5H Membrane HPM97_RS03060 ENOG4107RY6 amino acid HPM97_RS03065 ENOG4105CSV Glutaminase HPM97_RS03070 ENOG4105C59 p-type ATPase HPM97_RS03075 ENOG41081XE plasmid maintenance system antidote protein, xre family HPM97_RS03080 ENOG41080ET plasmid maintenance system killer protein HPM97_RS03085 ENOG4105MBR gumn family HPM97_RS03090 ENOG4108Z66 YbaK ebsC protein HPM97_RS03095 ENOG4105CGH 5'-nucleotidase HPM97_RS03100 ENOG4105EU0 Major facilitator Superfamily HPM97_RS03105 ENOG4105CKD glutathione-regulated potassium-efflux system protein HPM97_RS03115 ENOG4107RE1 Inosine-guanosine kinase HPM97_RS03150 ENOG4107QMP dna polymerase iii subunits gamma and tau HPM97_RS03160 ENOG4105WD1 Membrane HPM97_RS03165 ENOG4108URS primosomal replication protein n'' HPM97_RS03170 ENOG4106428 Protein of unknown function (DUF2496) HPM97_RS03175 ENOG4105EGS Mechanosensitive ion channel HPM97_RS03180 ENOG4107XI7 Tetr family transcriptional regulator HPM97_RS03185 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPM97_RS03190 ENOG4105BZS acriflavin resistance protein HPM97_RS03195 ENOG4108UKR Biofilm formation regulator YbaJ HPM97_RS03200 ENOG4105KF5 hemolysin expression-modulating protein HPM97_RS03205 ENOG4108UW5 maltose o-acetyltransferase HPM97_RS03210 ENOG4105GSJ Inner membrane protein ylaC HPM97_RS03215 ENOG41066DG (EAL) domain protein HPM97_RS03220 ENOG4105KCV RNA signal recognition particle 4.5S RNA HPM97_RS03230 ENOG41080UX Methyltransferase HPM97_RS03235 ENOG4108MNP Glycoprotein polysaccharide metabolism HPM97_RS03240 ENOG4105C29 acyl-CoA thioesterase HPM97_RS03245 ENOG4105BZU Histidine kinase HPM97_RS03250 ENOG4108YZA Nitrogen regulatory protein pii HPM97_RS03255 ENOG4105BZ1 (ABC) transporter HPM97_RS03260 ENOG4105BZ1 (ABC) transporter HPM97_RS03265 ENOG4108XM1 transcriptional regulator AsnC family HPM97_RS03275 ENOG4108NFA extracellular solute-binding protein HPM97_RS03285 ENOG4108TGP Thioesterase superfamily protein HPM97_RS03290 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HPM97_RS03295 ENOG4105EIN peptidylprolyl cis-trans isomerase HPM97_RS03300 ENOG4105K70 DNA-binding protein HPM97_RS03305 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HPM97_RS03325 ENOG4105M85 Bola protein HPM97_RS03330 ENOG4105IEY (LipO)protein HPM97_RS03335 ENOG4105EYM Major Facilitator superfamily HPM97_RS03340 ENOG4105E2S oxidase) subunit II HPM97_RS03345 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPM97_RS03350 ENOG4105CCU oxidase (Subunit III) HPM97_RS03355 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HPM97_RS03380 ENOG4107RDB Major Facilitator HPM97_RS03390 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HPM97_RS03395 ENOG4107S0N DJ-1 family HPM97_RS03410 ENOG4105CTB Polyprenyl synthetase HPM97_RS03420 ENOG4105CPC Aldo Keto reductase HPM97_RS03425 ENOG4108ZAI phosphatidylglycerophosphatase a HPM97_RS03430 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HPM97_RS03440 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HPM97_RS03445 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPM97_RS03460 ENOG4105D7V transposase HPM97_RS03475 ENOG4105DRB nucleoside-specific channel-forming protein HPM97_RS03480 ENOG4105N1F Hnh endonuclease HPM97_RS03490 ENOG4105X54 addiction module antidote protein HPM97_RS03495 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPM97_RS03500 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPM97_RS03505 ENOG4105VIE preprotein translocase, subunit YajC HPM97_RS03520 ENOG4108ZYK Acyl carrier protein phosphodiesterase HPM97_RS03530 ENOG4107R28 alpha amylase, catalytic region HPM97_RS03535 ENOG4105C85 amino acid HPM97_RS03540 ENOG4105CWM branched-chain amino acid transport system II carrier protein HPM97_RS03545 ENOG4105BZU Histidine kinase HPM97_RS03550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPM97_RS03555 ENOG4107RH8 nuclease SbcCD subunit D HPM97_RS03560 ENOG4105EYH Exonuclease HPM97_RS03565 ENOG4105F27 Major Facilitator HPM97_RS03570 ENOG4105DKQ ROK family HPM97_RS03595 ENOG4105HBA AroM protein HPM97_RS03600 ENOG4105SS3 HPM97_RS03615 ENOG4105II7 pyrroline-5-carboxylate reductase HPM97_RS03620 ENOG4105BZU Histidine kinase HPM97_RS03625 ENOG4105VIF phosphate starvation-inducible protein HPM97_RS03630 ENOG4105G6Z alkaline phosphatase HPM97_RS03645 ENOG4105CPF Cell wall formation (By similarity) HPM97_RS03650 ENOG4105UNH Membrane HPM97_RS03655 ENOG4105FR5 inner membrane protein YaiY HPM97_RS03660 ENOG4107QS8 (LipO)protein HPM97_RS03665 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HPM97_RS03670 ENOG4107R6D beta-lactam binding protein AmpH HPM97_RS03675 ENOG4108PNB DNA-binding transcriptional regulator HPM97_RS03685 ENOG4105D52 delta-aminolevulinic acid dehydratase HPM97_RS03690 ENOG4105E2B Taurine dioxygenase HPM97_RS03695 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPM97_RS03705 ENOG4106FTQ Taurine ABC transporter, periplasmic HPM97_RS03710 ENOG4107W19 lmbE family HPM97_RS03715 ENOG4108PBI Polysaccharide metabolism HPM97_RS03725 ENOG4105SRB Uncharacterized protein yaiO HPM97_RS03745 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HPM97_RS03750 ENOG4108SC4 )-transporter HPM97_RS03785 ENOG4108K2P TRANSCRIPTIONal HPM97_RS03790 ENOG4105ETE Transcriptional regulator (LacI family HPM97_RS03800 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HPM97_RS03805 ENOG4108UW5 maltose o-acetyltransferase HPM97_RS03810 ENOG4105DJ2 Major Facilitator Superfamily HPM97_RS03820 ENOG4107B2H carbonic anhydrase HPM97_RS03825 ENOG4105DND Transcriptional regulator HPM97_RS03830 ENOG4105DZC cytosine deaminase HPM97_RS03835 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HPM97_RS03840 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPM97_RS03845 ENOG4105DXD 2-methylcitrate dehydratase HPM97_RS03850 ENOG4105BZN citrate synthase HPM97_RS03855 ENOG4105CR4 methylisocitrate lyase HPM97_RS03860 ENOG4108JU7 Transcriptional regulator HPM97_RS03865 ENOG4105TDT uncharacterized protein yahO HPM97_RS03870 ENOG4105E82 cytochrome subunit of dehydrogenase HPM97_RS03885 ENOG4105DQ4 alcohol dehydrogenase HPM97_RS03890 ENOG4105DZC cytosine deaminase HPM97_RS03895 ENOG4105C5B carbamate kinase HPM97_RS03900 ENOG4107REC cytoplasmic protein HPM97_RS03905 ENOG4107R1Q Membrane protein FdrA HPM97_RS03910 ENOG4105N16 Protein of unknown function (DUF2877) HPM97_RS03915 ENOG4107SNB ankyrin repeat protein YahD HPM97_RS03920 ENOG4105SZ2 membrAne HPM97_RS03925 ENOG4108NUU Transcriptional regulator HPM97_RS03930 ENOG4105BZU Histidine kinase HPM97_RS03935 ENOG4105C94 Transporter HPM97_RS03955 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HPM97_RS03960 ENOG4107QR9 Iron-sulfur cluster binding protein HPM97_RS03965 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPM97_RS03970 ENOG4108K01 transcriptional regulator HPM97_RS03975 ENOG4107QN2 dihydrolipoyl dehydrogenase HPM97_RS03980 ENOG41066GK UPF0379 protein ykgI HPM97_RS03985 ENOG4108KBJ Inner membrane protein YkgB HPM97_RS03990 ENOG4105CV8 reductase HPM97_RS04000 ENOG4105TNG K13735 adhesin invasin HPM97_RS04010 ENOG4107SET aldo keto reductase HPM97_RS04015 ENOG4105EQ2 LysR family Transcriptional regulator HPM97_RS04020 ENOG410642W LysR family Transcriptional regulator HPM97_RS04025 ENOG4105ENX hydrolase HPM97_RS04030 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPM97_RS04075 ENOG4106PYX Receptor HPM97_RS04085 ENOG4105PI0 Ferredoxin HPM97_RS04090 ENOG4105R3P Inner membrane protein yagU HPM97_RS04200 ENOG4105DFP Integrase HPM97_RS04220 ENOG4105FCK Membrane HPM97_RS04230 ENOG4105V1F Fermentation respiration switch protein HPM97_RS04240 ENOG4105CIN aminoacyl-histidine dipeptidase HPM97_RS04255 ENOG4108S2Y peptide Chain Release factor HPM97_RS04265 ENOG4108HYG acetyltransferase HPM97_RS04285 ENOG4108UK5 Transposase HPM97_RS04290 ENOG4108YS0 lipoprotein YafL HPM97_RS04305 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HPM97_RS04310 ENOG4105E7A Glutamine amidotransferase HPM97_RS04320 ENOG4107QPN acyl-Coa dehydrogenase HPM97_RS04325 ENOG4108WN0 inhibitor of vertebrate lysozyme HPM97_RS04330 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPM97_RS04340 ENOG4107RZZ dna polymerase iii epsilon subunit HPM97_RS04350 ENOG4105D1A Methyltransferase HPM97_RS04355 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPM97_RS04360 ENOG4105E9H Lytic Murein transglycosylase HPM97_RS04365 ENOG4105F2W methyltransferase HPM97_RS04375 ENOG4105HEI LysR family (Transcriptional regulator HPM97_RS04380 ENOG4105CV8 reductase HPM97_RS04415 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HPM97_RS04420 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPM97_RS04425 ENOG4108UMI ABC transporter, permease HPM97_RS04430 ENOG4105D01 (LipO)protein HPM97_RS04435 ENOG4108R8X outer membrane lipoprotein HPM97_RS04440 ENOG4108R96 Methyltransferase, YaeB family HPM97_RS04450 ENOG4108UY0 (LipO)protein HPM97_RS04455 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HPM97_RS04460 ENOG4108YZN class I peptide chain release factor HPM97_RS04465 ENOG4108VWS Yaeq family HPM97_RS04475 ENOG4105M1T rho-binding antiterminator HPM97_RS04480 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HPM97_RS04485 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HPM97_RS04490 ENOG4105CXN decarboxylase HPM97_RS04500 ENOG4105C0B DNA polymerase III (alpha subunit) HPM97_RS04505 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPM97_RS04525 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HPM97_RS04530 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HPM97_RS04540 ENOG4105DZP Membrane-associated zinc metalloprotease HPM97_RS04545 ENOG4105KNE Phosphatidate cytidylyltransferase HPM97_RS04550 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HPM97_RS04555 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HPM97_RS04580 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPM97_RS04600 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HPM97_RS04605 ENOG4105C0H protease HPM97_RS04620 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HPM97_RS04625 ENOG4105EN6 Membrane HPM97_RS04650 ENOG4105S6R Iron-hydroxamate transporter permease subunit HPM97_RS04655 ENOG4105J76 Periplasmic binding protein HPM97_RS04660 ENOG4105E0A ABC, transporter HPM97_RS04665 ENOG4105E0K tonB-dependent siderophore receptor HPM97_RS04670 ENOG4105BZ4 penicillin-binding protein HPM97_RS04675 ENOG4105CQ7 ATP-dependent helicase HPM97_RS04680 ENOG4107XID 2'-5' rna ligase HPM97_RS04695 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HPM97_RS04700 ENOG4105DJ0 Poly(A) Polymerase HPM97_RS04705 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HPM97_RS04715 ENOG4108VEV chaperone HPM97_RS04720 ENOG4105CW0 outer membrane usher protein HPM97_RS04725 ENOG4108XEY fimbrial-like adhesin protein HPM97_RS04730 ENOG4105SYG Fimbrial protein HPM97_RS04735 ENOG4105SN2 fimbrial-like adhesin protein HPM97_RS04740 ENOG4105P0Q fimbrial-like protein YadC HPM97_RS04755 ENOG4108A32 Transposase HPM97_RS04765 ENOG4107BJW polysaccharide deacetylase HPM97_RS04770 ENOG4108YTN IIa component HPM97_RS04775 ENOG4105E3A (ABC) transporter HPM97_RS04780 ENOG4105DA5 (ABC) transporter HPM97_RS04785 ENOG41077A9 carbonic anhydrase HPM97_RS04790 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPM97_RS04795 ENOG4105DZG Dehydrogenase HPM97_RS04800 ENOG4105E3B Multicopper oxidase HPM97_RS04805 ENOG4108ZRK uncharacterized protein yacC HPM97_RS04825 ENOG4107QIJ Aconitate hydratase 2 HPM97_RS04830 ENOG4108NST exported protein HPM97_RS04840 ENOG4107QN2 dihydrolipoyl dehydrogenase HPM97_RS04845 ENOG4107QSN dihydrolipoamide acetyltransferase HPM97_RS04850 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPM97_RS04855 ENOG41073TP transcriptional regulator HPM97_RS04865 ENOG4106A72 regulatory protein AmpE HPM97_RS04870 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HPM97_RS04875 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPM97_RS04880 ENOG4108ZUW Major pilin subunit HPM97_RS04885 ENOG4107QHF type ii secretion system protein e HPM97_RS04890 ENOG4105D7Q type ii secretion system HPM97_RS04905 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HPM97_RS04920 ENOG4105M6F mutator MutT protein HPM97_RS04940 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPM97_RS04945 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HPM97_RS04950 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HPM97_RS04955 ENOG4105CPF Cell wall formation (By similarity) HPM97_RS04970 ENOG4105CNI cell division protein FtsW HPM97_RS04975 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HPM97_RS04985 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HPM97_RS04990 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HPM97_RS04995 ENOG4105CJN penicillin-binding protein HPM97_RS05000 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HPM97_RS05015 ENOG4107B7Y DNA-binding transcriptional regulator FruR HPM97_RS05025 ENOG4108ZP8 Acetolactate synthase small subunit HPM97_RS05030 ENOG4105C7K acetolactate synthase HPM97_RS05040 ENOG41064T2 transcriptional regulator, lysR family HPM97_RS05085 ENOG4105DP9 ABC transporter HPM97_RS05090 ENOG4106SMU thiamine transporter membrane protein HPM97_RS05100 ENOG4108KF1 Membrane HPM97_RS05115 ENOG41063TF transcriptional regulator (AraC HPM97_RS05130 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HPM97_RS05135 ENOG4105CQ2 DNA polymerase HPM97_RS05145 ENOG4105D3G Pseudouridine synthase HPM97_RS05150 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HPM97_RS05160 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HPM97_RS05200 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HPM97_RS05205 ENOG4105CKD glutathione-regulated potassium-efflux system protein HPM97_RS05215 ENOG4105C54 Major Facilitator superfamily HPM97_RS05220 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HPM97_RS05225 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPM97_RS05240 ENOG4105C94 Transporter HPM97_RS05270 ENOG4108XNW Transcriptional activatory protein CaiF HPM97_RS05275 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HPM97_RS05280 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HPM97_RS05300 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HPM97_RS05315 ENOG4105DTN riboflavin biosynthesis protein ribF HPM97_RS05320 ENOG410647N response to DNA damage stimulus HPM97_RS05340 ENOG41063Z6 transcriptional regulator, lysR family HPM97_RS05345 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HPM97_RS05355 ENOG41061MV Arylsulfatase HPM97_RS05365 ENOG4105WI6 cell killing protein encoded within cryptic prophage HPM97_RS05385 ENOG4108QUJ UPF0174 protein YaaW HPM97_RS05390 ENOG4106HK8 GPR1 FUN34 yaaH family protein HPM97_RS05395 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPM97_RS05405 ENOG4105BZG amino acid carrier protein HPM97_RS05415 ENOG41062C6 Protein of unknown function (DUF2502) HPM97_RS05420 ENOG4105D98 threonine synthase HPM97_RS05430 ENOG4105CFH Aspartokinase HPM97_RS05440 ENOG4106FVC RNA methyltransferase HPM97_RS05445 ENOG410759A HPM97_RS05450 ENOG41065U4 response regulator HPM97_RS05455 ENOG4105CT7 inner membrane cred family protein HPM97_RS05460 ENOG4105EB3 Histidine kinase HPM97_RS05465 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPM97_RS05470 ENOG4108RH0 Crea protein HPM97_RS05475 ENOG4105UEI Transcriptional Regulator AraC Family HPM97_RS05495 ENOG4107SC1 transglycosylase HPM97_RS05500 ENOG4105C5H ABC transporter HPM97_RS05510 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HPM97_RS05515 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPM97_RS05520 ENOG4105EAC phosphoserine phosphatase HPM97_RS05525 ENOG41062Z9 Membrane HPM97_RS05540 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HPM97_RS05560 ENOG4105G0K glycine radical enzyme YjjI family HPM97_RS05565 ENOG41076CZ activating enzyme HPM97_RS05570 ENOG4105EYA deoxyribonuclease HPM97_RS05575 ENOG4108NRW Phospholipase, patatin family HPM97_RS05585 ENOG4105K3G Periplasmic Protein HPM97_RS05595 ENOG4105PAD Hydrolase HPM97_RS05600 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HPM97_RS05605 ENOG4108WPU DNA polymerase III subunit psi HPM97_RS05630 ENOG4105YBH Protein of unknown function (DUF1435) HPM97_RS05635 ENOG4108819 ferric iron reductase HPM97_RS05640 ENOG4108T94 DNA-binding transcriptional activator BglJ HPM97_RS05645 ENOG4108N8T regulatoR HPM97_RS05650 ENOG4105DWK Membrane HPM97_RS05665 ENOG4106CVF DNA replication protein HPM97_RS05670 ENOG4105RI1 glycoprotein receptor HPM97_RS05680 ENOG4105CPQ Dehydrogenase HPM97_RS05685 ENOG410617M Transcriptional regulator HPM97_RS05690 ENOG4108I5G Major Facilitator superfamily HPM97_RS05695 ENOG4105C8Q Methyl-accepting chemotaxis HPM97_RS05705 ENOG4108IA2 Sodium pantothenate symporter HPM97_RS05725 ENOG4105D22 carbon starvation protein HPM97_RS05730 ENOG4105VCD cytoplasmic protein HPM97_RS05735 ENOG4105CKI cobalamin synthesis protein HPM97_RS05750 ENOG4106H3A restriction HPM97_RS05770 ENOG4106DIZ Domain of unknown function (DUF1127) HPM97_RS05775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPM97_RS05790 ENOG41083G8 Multidrug resistance protein MdtM HPM97_RS05795 ENOG4106BRA Membrane HPM97_RS05800 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HPM97_RS05805 ENOG4105CIZ coA-substrate-specific enzyme activase HPM97_RS05820 ENOG4105CBP Major Facilitator HPM97_RS05830 ENOG41074DU domain protein HPM97_RS05835 ENOG4108P2H Inner membrane protein YjiG HPM97_RS05840 ENOG4105DYB Isoaspartyl dipeptidase HPM97_RS05845 ENOG4107YNJ LysR family Transcriptional regulator HPM97_RS05865 ENOG4105C6F GntR Family Transcriptional Regulator HPM97_RS05870 ENOG4105DEI Mannitol dehydrogenase HPM97_RS05880 ENOG4107EFN gluconate transport system permease 3 HPM97_RS05885 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HPM97_RS05890 ENOG4108T65 Fimbrial HPM97_RS05895 ENOG4108SQA Fimbrial HPM97_RS05900 ENOG4105CW0 outer membrane usher protein HPM97_RS05905 ENOG4108NAE Fimbrial chaperone protein HPM97_RS05910 ENOG4108S54 Fimbrial protein HPM97_RS05915 ENOG4108RQP Major type 1 subunit fimbrin HPM97_RS05920 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HPM97_RS05925 ENOG4108W9T type 1 fimbriae regulatory protein HPM97_RS05930 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HPM97_RS05935 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HPM97_RS05955 ENOG4105DZR Type I site-specific deoxyribonuclease HPM97_RS05970 ENOG4105CVR type I restriction-modification system HPM97_RS05990 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPM97_RS06005 ENOG4105DQ4 alcohol dehydrogenase HPM97_RS06010 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HPM97_RS06015 ENOG4105CPQ Dehydrogenase HPM97_RS06020 ENOG4105CHR reductase HPM97_RS06025 ENOG4105C6Z Gluconate HPM97_RS06030 ENOG4105K2J Transcriptional regulator HPM97_RS06035 ENOG4105D7A ATP-binding protein HPM97_RS06040 ENOG4108K5H permease YjgP YjgQ family protein HPM97_RS06045 ENOG4108M8S permease YjgP YjgQ family protein HPM97_RS06055 ENOG4105MYG DNA polymerase iii, chi subunit HPM97_RS06060 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPM97_RS06065 ENOG4108M3P Membrane HPM97_RS06070 ENOG4108MJ3 acetyltransferase HPM97_RS06075 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HPM97_RS06090 ENOG4105XEP YhcH YjgK YiaL family protein HPM97_RS06095 ENOG4108XFH Transcriptional regulator HPM97_RS06100 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HPM97_RS06105 ENOG4108UQ8 endoribonuclease L-psp HPM97_RS06110 ENOG4107C93 pyrBI operon leader peptide HPM97_RS06125 ENOG4105KME endoribonuclease L-psp HPM97_RS06130 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HPM97_RS06140 ENOG4105D4X repressor HPM97_RS06145 ENOG4105C5Y PTS System HPM97_RS06150 ENOG4105CG3 alpha amylase, catalytic region HPM97_RS06155 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HPM97_RS06160 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HPM97_RS06165 ENOG4105K4U addiction module toxin, RelE StbE family HPM97_RS06175 ENOG4108XVM Cytochrome b(562) HPM97_RS06180 ENOG4105CMS peptidase U62, modulator of DNA gyrase HPM97_RS06190 ENOG4105DFU Cell wall formation (By similarity) HPM97_RS06200 ENOG41062B0 ABC transporter, permease HPM97_RS06205 ENOG4107R9N ABC transporter HPM97_RS06210 ENOG4105C2J ABC transporter HPM97_RS06215 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HPM97_RS06220 ENOG4105F0N pyrophosphate phospho-hydrolase HPM97_RS06225 ENOG4105MZG transcriptional modulator of maze toxin, mazf HPM97_RS06230 ENOG41087RY SpoVT_AbrB HPM97_RS06235 ENOG4108ZHD aig2 family HPM97_RS06240 ENOG4105MA0 exported protein HPM97_RS06245 ENOG4105CFU surface antigen HPM97_RS06255 ENOG4105C37 (CBS) domain HPM97_RS06260 ENOG41061GZ Protein of unknown function (DUF1107) HPM97_RS06265 ENOG4108UUE Transcriptional regulator HPM97_RS06270 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HPM97_RS06275 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HPM97_RS06280 ENOG4105KVH Transcriptional regulator HPM97_RS06285 ENOG4105ECR NmrA family HPM97_RS06290 ENOG4105DXC membrane HPM97_RS06315 ENOG4108V1T peptidylprolyl cis-trans isomerase HPM97_RS06320 ENOG4105FHY Opacity-associated protein A HPM97_RS06330 ENOG4105CHR reductase HPM97_RS06340 ENOG4105E39 Enoyl-CoA hydratase HPM97_RS06345 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HPM97_RS06350 ENOG4107S3R L-aspartate oxidase HPM97_RS06355 ENOG41069H7 transport system small permease component HPM97_RS06360 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPM97_RS06365 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPM97_RS06375 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HPM97_RS06390 ENOG4105KIT UPF0379 protein yjfY HPM97_RS06420 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HPM97_RS06435 ENOG4108MXZ Esterase HPM97_RS06440 ENOG4105WSB biofilm stress and motility protein A HPM97_RS06445 ENOG4105S17 UPF0379 protein yjfN HPM97_RS06450 ENOG4105CSU acyl-Coa dehydrogenase HPM97_RS06455 ENOG4106032 Glutathionylspermidine synthase HPM97_RS06460 ENOG4108KXT Conserved Protein HPM97_RS06465 ENOG4105Z6B inner membrane protein yjfl HPM97_RS06470 ENOG4107VNS Protein of unknown function (DUF2491) HPM97_RS06475 ENOG4108P9J Phage shock protein A HPM97_RS06480 ENOG4105FUX Conserved Protein HPM97_RS06485 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPM97_RS06490 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HPM97_RS06510 ENOG4105EPW hflc protein HPM97_RS06515 ENOG4107QJR hflk protein HPM97_RS06520 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPM97_RS06540 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPM97_RS06545 ENOG4105K8N protein family UPF0079, ATPase HPM97_RS06550 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HPM97_RS06595 ENOG4105EGS Mechanosensitive ion channel HPM97_RS06600 ENOG4106CG8 Inner membrane protein YjeO HPM97_RS06620 ENOG4107SC7 Inner membrane transporter yjeM HPM97_RS06630 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HPM97_RS06635 ENOG4105E33 succinate dehydrogenase HPM97_RS06655 ENOG4105QNF Outer membrane lipoprotein HPM97_RS06660 ENOG4105KPY Small multidrug resistance protein HPM97_RS06665 ENOG4106BSU Entericidin B HPM97_RS06670 ENOG4107PEH Entericidin EcnA/B family HPM97_RS06680 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPM97_RS06685 ENOG4105MTB Uncharacterized protein YjeJ HPM97_RS06690 ENOG4108ZVF (LipO)protein HPM97_RS06705 ENOG4105DVH amino acid HPM97_RS06710 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HPM97_RS06715 ENOG4108IJ0 Aspartate ammonia-lyase HPM97_RS06720 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM97_RS06735 ENOG4108SIC Transcriptional regulator HPM97_RS06780 ENOG4108M3R transcriptional activator CadC HPM97_RS06785 ENOG4105D5Q Arginine ornithine antiporter HPM97_RS06790 ENOG4105CXN decarboxylase HPM97_RS06795 ENOG4105DUX Transporter HPM97_RS06800 ENOG4105CRK lysyL-tRNA synthetase HPM97_RS06815 ENOG410830R acetyltransferase HPM97_RS06820 ENOG4105VR1 Pfam:DUF1271 HPM97_RS06825 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPM97_RS06830 ENOG4108MRH transcriptional regulatory protein HPM97_RS06835 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM97_RS06840 ENOG4107GFK fumarate HPM97_RS06845 ENOG4108R5S membrane HPM97_RS06850 ENOG4105F8D glycoside hydrolase family 4 HPM97_RS06855 ENOG4108K2B transcriptional regulator HPM97_RS06860 ENOG4105CXN decarboxylase HPM97_RS06865 ENOG4106ZGR Transcriptional regulator HPM97_RS06870 ENOG4105D5Q Arginine ornithine antiporter HPM97_RS06875 ENOG4105DIJ Phosphoethanolamine transferase HPM97_RS06880 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPM97_RS06885 ENOG4105ECM Sensor protein basS pmrB HPM97_RS06895 ENOG4105CSH Transporter HPM97_RS06900 ENOG4108YIV HPM97_RS06905 ENOG4108F5E vimentin HPM97_RS06910 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HPM97_RS06915 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HPM97_RS06920 ENOG4105D5T phosphonate abc transporter HPM97_RS06925 ENOG4105EHI Phosphonate ABC transporter, periplasmic HPM97_RS06935 ENOG4107RJJ Transcriptional regulator HPM97_RS06940 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HPM97_RS06945 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HPM97_RS06950 ENOG4105EKV Phosphonate metabolism protein HPM97_RS06955 ENOG4105FT8 Phosphonate metabolism HPM97_RS06960 ENOG4105ENV phosphonate C-P lyase system protein PhnK HPM97_RS06965 ENOG4105HRV phosphonate c-p lyase system protein phnl HPM97_RS06970 ENOG4105FD8 phosphonate metabolism protein PhnM HPM97_RS06980 ENOG410849A acetyltransferase, (GNAT) family HPM97_RS06985 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HPM97_RS06995 ENOG4108YZG isomerase HPM97_RS07000 ENOG4105NYY transcriptional regulator, RpiR HPM97_RS07005 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPM97_RS07010 ENOG4105C2J ABC transporter HPM97_RS07015 ENOG4105CNN ABC, transporter HPM97_RS07020 ENOG4105UP7 3-epimerase HPM97_RS07025 ENOG4107TFG D-allose kinase HPM97_RS07030 ENOG4105EUZ Beta-lactamase domain protein HPM97_RS07035 ENOG4106833 HPM97_RS07040 ENOG4105J12 Multidrug resistance protein mdtN HPM97_RS07045 ENOG4108MI0 Resistance protein HPM97_RS07050 ENOG4105ETP RND efflux system, outer membrane lipoprotein HPM97_RS07060 ENOG41082ND Uncharacterized protein yjcO HPM97_RS07065 ENOG4105CK2 sodium dicarboxylate symporter HPM97_RS07070 ENOG4108W0S formate-dependent nitrite reductase complex HPM97_RS07080 ENOG4108QKW cytochrome c-type biogenesis protein HPM97_RS07085 ENOG4105DVI reductase, NrfD HPM97_RS07090 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPM97_RS07095 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HPM97_RS07105 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPM97_RS07110 ENOG41062QD Membrane HPM97_RS07120 ENOG4105EEQ Na H antiporter HPM97_RS07125 ENOG4105C7N Xanthine uracil vitamin C permease HPM97_RS07130 ENOG4108Z4X TRANSCRIPTIONal HPM97_RS07135 ENOG4108W3Q Transcriptional regulator HPM97_RS07140 ENOG4108M8H domain protein HPM97_RS07145 ENOG4105PMV Membrane HPM97_RS07150 ENOG4108UUM single-stranded DNA-binding protein HPM97_RS07155 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPM97_RS07160 ENOG4105MSB protein, conserved in bacteria HPM97_RS07165 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HPM97_RS07170 ENOG4105F0S class B acid phosphatase HPM97_RS07180 ENOG4105CGF Aromatic amino acid aminotransferase HPM97_RS07185 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPM97_RS07190 ENOG4105CDU Replicative dna helicase HPM97_RS07195 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPM97_RS07200 ENOG4105P4Z Phage shock protein G HPM97_RS07205 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPM97_RS07215 ENOG4105MYN Zinc uptake regulation protein HPM97_RS07220 ENOG4105VDW Csbd family HPM97_RS07225 ENOG4107R73 Mate efflux family protein HPM97_RS07235 ENOG41080IJ Diacylglycerol kinase HPM97_RS07260 ENOG4107W52 maltose operon periplasmic protein HPM97_RS07270 ENOG4108IJ9 (ABC) transporter HPM97_RS07275 ENOG4107FKK extracellular solute-binding protein family 1 HPM97_RS07280 ENOG4105D56 permease protein HPM97_RS07285 ENOG4105EG2 ABC transporter, permease HPM97_RS07300 ENOG4105E3R (LipO)protein HPM97_RS07305 ENOG4108Q9C Periplasmic Protein HPM97_RS07310 ENOG4108MDC (LipO)protein HPM97_RS07325 ENOG4105CFH Aspartokinase HPM97_RS07340 ENOG4107SC1 transglycosylase HPM97_RS07420 ENOG410685N tail fiber protein HPM97_RS07435 ENOG410756H nucleotidyltransferase HPM97_RS07445 ENOG4108ZR5 Conserved Protein HPM97_RS07450 ENOG4105FE9 pseudouridine synthase HPM97_RS07455 ENOG4105DKT Transcriptional regulator HPM97_RS07460 ENOG4105CHR reductase HPM97_RS07465 ENOG4108XCU pts system HPM97_RS07470 ENOG4105KPI PTS system sorbose subfamily IIB component HPM97_RS07475 ENOG4105ETZ PTS System HPM97_RS07480 ENOG4105F3R pts system mannose fructose sorbose family iid HPM97_RS07485 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HPM97_RS07490 ENOG4105F9E Shikimate 5-dehydrogenase HPM97_RS07500 ENOG4105EAM Na Pi-cotransporter HPM97_RS07505 ENOG4105C3R Methionine synthase HPM97_RS07510 ENOG41069M3 Transcriptional regulator HPM97_RS07515 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HPM97_RS07520 ENOG4108I9X Isocitrate lyase HPM97_RS07525 ENOG4107QP3 malate synthase g HPM97_RS07535 ENOG4105K5X acetyltransferase HPM97_RS07565 ENOG4105C12 Phosphoribosylglycinamide synthetase HPM97_RS07570 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPM97_RS07575 ENOG4105BZU Histidine kinase HPM97_RS07580 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HPM97_RS07585 ENOG4108T8B Protein of unknown function (DUF1481) HPM97_RS07595 ENOG4105R2J Conserved Protein HPM97_RS07630 ENOG4105D06 uba thif-type nad fad binding protein HPM97_RS07635 ENOG4105WHD thiamine biosynthesis protein ThiS HPM97_RS07645 ENOG4105D41 biosynthesis protein thiH HPM97_RS07665 ENOG4108RVA ribokinase HPM97_RS07700 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HPM97_RS07705 ENOG4105PM1 preprotein translocase subunit SecE HPM97_RS07740 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HPM97_RS07770 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HPM97_RS07775 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HPM97_RS07785 ENOG4108Y73 Membrane HPM97_RS07790 ENOG4105EJ2 Transcriptional regulator HPM97_RS07800 ENOG4105C5Q Transcriptional regulator HPM97_RS07805 ENOG4108I5G Major Facilitator superfamily HPM97_RS07810 ENOG4105CXK mandelate racemase muconate lactonizing HPM97_RS07815 ENOG4105CH7 arginosuccinase HPM97_RS07825 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HPM97_RS07840 ENOG4105DIJ Phosphoethanolamine transferase HPM97_RS07845 ENOG4106R3P AraC family transcriptional regulator HPM97_RS07850 ENOG4108XCZ PTS System HPM97_RS07855 ENOG4108AHH pyruvate formate lyase II activase HPM97_RS07865 ENOG4108YRF PTS System HPM97_RS07870 ENOG4105DM4 PTS System HPM97_RS07875 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPM97_RS07880 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPM97_RS07885 ENOG4105DCT glycerol dehydrogenase HPM97_RS07890 ENOG4108XC3 NADH ubiquinone oxidoreductase HPM97_RS07895 ENOG4108Q5Y Membrane HPM97_RS07905 ENOG4105SYT Methylenetetrahydrofolate reductase HPM97_RS07910 ENOG4105CGH 5'-nucleotidase HPM97_RS07920 ENOG4105CGH 5'-nucleotidase HPM97_RS07925 ENOG4105CGH 5'-nucleotidase HPM97_RS07930 ENOG4105DRB nucleoside-specific channel-forming protein HPM97_RS07935 ENOG4105CFH Aspartokinase HPM97_RS07940 ENOG4105C28 cystathionine HPM97_RS07950 ENOG4107S01 Repressor protein MetJ HPM97_RS07960 ENOG4105C25 Primosomal protein n' HPM97_RS07965 ENOG4105ETE Transcriptional regulator (LacI family HPM97_RS07970 ENOG41063M6 Cell Division Protein HPM97_RS07985 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HPM97_RS08010 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPM97_RS08020 ENOG4105CBT Fructose-1,6-bisphosphatase HPM97_RS08025 ENOG4105DP0 ferredoxin-NADP reductase HPM97_RS08035 ENOG41065TG regulatoR HPM97_RS08040 ENOG4108VTS Membrane HPM97_RS08045 ENOG4105EBK exported protein HPM97_RS08060 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HPM97_RS08075 ENOG4105ZTC transcriptional activator, Ogr delta HPM97_RS08115 ENOG4108C33 Resolvase HPM97_RS08125 ENOG4105PTU response to oxidative stress HPM97_RS08130 ENOG4108US3 tail fiber assembly HPM97_RS08230 ENOG4105ED4 portal protein HPM97_RS08245 ENOG4105NI8 Cytosine-specific methyltransferase HPM97_RS08250 ENOG4105VZ1 Replication Protein HPM97_RS08295 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPM97_RS08300 ENOG4105FMW periplasmic HPM97_RS08305 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPM97_RS08310 ENOG4105E0F Histidine kinase HPM97_RS08315 ENOG4108RPX mosc domain containing protein HPM97_RS08325 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPM97_RS08335 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HPM97_RS08350 ENOG4105DKG l-rhamnose isomerase HPM97_RS08370 ENOG41064BA PTS system, fructose-specific, IIA component HPM97_RS08375 ENOG4105DM4 PTS System HPM97_RS08380 ENOG4105CN9 Peptidase m42 family protein HPM97_RS08385 ENOG4106C3V frv operon regulatory protein HPM97_RS08390 ENOG4108V87 frv operon regulatory protein HPM97_RS08400 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HPM97_RS08415 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPM97_RS08420 ENOG4108MG3 formate dehydrogenase HPM97_RS08435 ENOG41068KX affects formate dehydrogenase-N HPM97_RS08450 ENOG4105SUU thioesterase domain HPM97_RS08465 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HPM97_RS08470 ENOG4105E98 transcriptional regulator DeoR family HPM97_RS08475 ENOG4108MGF sugar kinase HPM97_RS08480 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPM97_RS08485 ENOG4105D2M Aldolase HPM97_RS08490 ENOG4107QKS N-acylglucosamine 2-epimerase HPM97_RS08495 ENOG4107WI4 Aldose-1-epimerase HPM97_RS08500 ENOG4105CJQ hydrolase, family 31 HPM97_RS08505 ENOG4105CT4 transporter HPM97_RS08510 ENOG4105CT4 transporter HPM97_RS08515 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HPM97_RS08520 ENOG4105R9B Major Facilitator HPM97_RS08525 ENOG4108KHF Resistance protein HPM97_RS08530 ENOG4108K85 Transcriptional regulator HPM97_RS08535 ENOG4105VNT transposase (IS4 family) protein HPM97_RS08540 ENOG4105CI3 gtp-binding protein typa HPM97_RS08545 ENOG4105C5F glutamine synthetase HPM97_RS08550 ENOG4105CUX Signal transduction histidine kinase HPM97_RS08555 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPM97_RS08560 ENOG4106FIY HPM97_RS08565 ENOG4105D4P Coproporphyrinogen iii oxidase HPM97_RS08580 ENOG4105C2M dna polymerase I HPM97_RS08585 ENOG4106HNH Acyl-transferase HPM97_RS08595 ENOG4108Z33 Thiol disulfide Interchange Protein HPM97_RS08600 ENOG4105E27 serine threonine protein kinase HPM97_RS08605 ENOG4105PC1 Conserved Protein HPM97_RS08610 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HPM97_RS08615 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HPM97_RS08645 ENOG4108RR8 protoporphyrinogen oxidase HPM97_RS08650 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HPM97_RS08655 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HPM97_RS08675 ENOG4108EX3 reductase HPM97_RS08680 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HPM97_RS08685 ENOG4105MDZ Transcriptional activator rfaH HPM97_RS08695 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HPM97_RS08700 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HPM97_RS08705 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HPM97_RS08715 ENOG4105JC1 sterol-binding domain protein HPM97_RS08725 ENOG4105CGY Dna recombination protein HPM97_RS08730 ENOG4107HP6 Transcriptional regulator HPM97_RS08735 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HPM97_RS08740 ENOG4108RTU Aldolase HPM97_RS08745 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HPM97_RS08760 ENOG4108I5U Uridine phosphorylase HPM97_RS08765 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HPM97_RS08770 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HPM97_RS08780 ENOG4107R1Q Membrane protein FdrA HPM97_RS08785 ENOG4107REC cytoplasmic protein HPM97_RS08790 ENOG4105C5B carbamate kinase HPM97_RS08800 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HPM97_RS08805 ENOG4105F52 Transcriptional regulator HPM97_RS08815 ENOG4105DZ2 Transcriptional regulator HPM97_RS08820 ENOG4105EMK carboxylate amino acid amine transporter HPM97_RS08825 ENOG4105DQF Hydrolase HPM97_RS08830 ENOG4108EUD Lysophospholipase HPM97_RS08835 ENOG410829K Lysine exporter protein (Lyse ygga) HPM97_RS08840 ENOG4105CCF Lysine exporter protein (Lyse ygga) HPM97_RS08845 ENOG4105C9U ATP-dependent DNA helicase RecQ HPM97_RS08850 ENOG4105HDD phospholipase HPM97_RS08855 ENOG4108VUY thioesterase Superfamily protein HPM97_RS08860 ENOG4105FR1 rard protein HPM97_RS08875 ENOG4107QUT magnesium and cobalt transport protein CorA HPM97_RS08880 ENOG4108T58 Mg2 transport protein CorA HPM97_RS08885 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HPM97_RS08890 ENOG4105C4R Atp-dependent dna helicase HPM97_RS08895 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HPM97_RS08905 ENOG4105CT0 Protein of unknown function, DUF484 HPM97_RS08915 ENOG4105S7Z (LipO)protein HPM97_RS08935 ENOG4107T0K Adenylate cyclase HPM97_RS08945 ENOG41076E6 Uroporphyrinogen-III Synthase HPM97_RS08950 ENOG4105ECF c-methyltransferase HPM97_RS08955 ENOG410601J HemY protein HPM97_RS08960 ENOG4105ENH Sulfatase HPM97_RS08965 ENOG4105C4X radical SAM domain protein HPM97_RS08990 ENOG4105C85 amino acid HPM97_RS09010 ENOG4105EGZ biosynthesis protein HPM97_RS09015 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPM97_RS09020 ENOG4108WJ1 acetyltransferase HPM97_RS09025 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HPM97_RS09030 ENOG4105C1B dTDP-glucose 4-6-dehydratase HPM97_RS09035 ENOG4107QQG Dehydrogenase HPM97_RS09040 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPM97_RS09045 ENOG4105SFE lipopolysaccharide biosynthesis protein HPM97_RS09050 ENOG4105ESV Glycosyl transferase, family 4 HPM97_RS09055 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HPM97_RS09080 ENOG4105C4R Atp-dependent dna helicase HPM97_RS09090 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HPM97_RS09100 ENOG4105EMY transcriptional regulator HPM97_RS09105 ENOG4105C7B Threonine dehydratase HPM97_RS09115 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPM97_RS09120 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HPM97_RS09140 ENOG4105C0P Mg chelatase subunit ChlI HPM97_RS09145 ENOG4108WFC UPF0438 protein yifE HPM97_RS09185 ENOG4107EJG GntR family transcriptional regulator HPM97_RS09190 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPM97_RS09195 ENOG4105ETE Transcriptional regulator (LacI family HPM97_RS09200 ENOG4108RVA ribokinase HPM97_RS09205 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPM97_RS09210 ENOG4105CNN ABC, transporter HPM97_RS09215 ENOG4105C2J ABC transporter HPM97_RS09245 ENOG4108VVK transcriptional Regulator, AsnC HPM97_RS09250 ENOG4105QTB Flavodoxin HPM97_RS09265 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HPM97_RS09315 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HPM97_RS09330 ENOG4105CW0 outer membrane usher protein HPM97_RS09340 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HPM97_RS09345 ENOG4105C8U phosphate abc transporter HPM97_RS09350 ENOG4105E2Z phosphate ABC transporter (Permease HPM97_RS09355 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HPM97_RS09360 ENOG4108UTW Plays a role in the regulation of phosphate uptake HPM97_RS09390 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HPM97_RS09395 ENOG4105C7N Xanthine uracil vitamin C permease HPM97_RS09400 ENOG4108YYH Nadph-dependent fmn reductase HPM97_RS09405 ENOG4105E8Q phosphopantetheinyl transferase HPM97_RS09410 ENOG4105G2Y Transcriptional regulator HPM97_RS09420 ENOG4108P6C Tryptophan transporter of low affinity HPM97_RS09455 ENOG4105VG0 50S ribosomal protein l34 HPM97_RS09470 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPM97_RS09480 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPM97_RS09485 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HPM97_RS09490 ENOG410667J hydrolase HPM97_RS09495 ENOG410657R replicase EC 2.7 HPM97_RS09500 ENOG4105EMF GntR family transcriptional regulator HPM97_RS09505 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HPM97_RS09510 ENOG4108RTU Aldolase HPM97_RS09520 ENOG4105DJB Major Facilitator Superfamily HPM97_RS09530 ENOG4105D99 atp gtp-binding protein HPM97_RS09535 ENOG4105R2A (LipO)protein HPM97_RS09555 ENOG4105FDP GntR family transcriptional regulator HPM97_RS09560 ENOG4105CI1 PTS System HPM97_RS09565 ENOG4105F8D glycoside hydrolase family 4 HPM97_RS09570 ENOG4108AHD Transcriptional regulator HPM97_RS09575 ENOG4107RUZ Sss sodium solute transporter superfamily HPM97_RS09580 ENOG4105CBG Sulfatase HPM97_RS09585 ENOG4105VG5 Membrane HPM97_RS09590 ENOG4105JP4 Inner membrane protein yidG HPM97_RS09595 ENOG4105J13 transcriptional regulator HPM97_RS09600 ENOG4105E5M Multidrug resistance protein D HPM97_RS09615 ENOG4105C7K acetolactate synthase HPM97_RS09620 ENOG4105M71 acetolactate synthase 1 regulatory subunit HPM97_RS09635 ENOG4108KX4 response regulator HPM97_RS09640 ENOG4105BZU Histidine kinase HPM97_RS09645 ENOG4105CXY transporter HPM97_RS09650 ENOG4105CXY transporter HPM97_RS09660 ENOG4105C7N Xanthine uracil vitamin C permease HPM97_RS09665 ENOG4108SAJ Protein of unknown function (DUF1198) HPM97_RS09685 ENOG4105TNG K13735 adhesin invasin HPM97_RS09690 ENOG4108YAB Invasion protein HPM97_RS09695 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HPM97_RS09720 ENOG4105T8A Uncharacterized protein YicS HPM97_RS09725 ENOG4105D01 (LipO)protein HPM97_RS09730 ENOG4108UZ3 Transporter HPM97_RS09735 ENOG4105S8Q sugar efflux transporter HPM97_RS09750 ENOG4105CT4 transporter HPM97_RS09755 ENOG4105CJQ hydrolase, family 31 HPM97_RS09760 ENOG4105ETD TRANSCRIPTIONal HPM97_RS09765 ENOG4105DM4 PTS System HPM97_RS09770 ENOG4108YRF PTS System HPM97_RS09775 ENOG4105DM4 PTS System HPM97_RS09780 ENOG4105D2N Aldolase HPM97_RS09790 ENOG4105DKQ ROK family HPM97_RS09800 ENOG4105JV1 AsmA family HPM97_RS09805 ENOG4105C2W permease HPM97_RS09810 ENOG4105D6U Sodium Glutamate Symporter HPM97_RS09815 ENOG4105CB5 ATP-dependent DNA helicase recG HPM97_RS09820 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HPM97_RS09825 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPM97_RS09835 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HPM97_RS09845 ENOG4105EN6 Membrane HPM97_RS09850 ENOG4105F5P DNA-damage-inducible protein d HPM97_RS09855 ENOG4105DSJ YicC domain protein HPM97_RS09875 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HPM97_RS09880 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HPM97_RS09890 ENOG4105KDC 50s ribosomal protein l28 HPM97_RS09910 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HPM97_RS09915 ENOG4105DKP glycosyl transferase, family 9 HPM97_RS09920 ENOG4107RJ7 Glycosyl transferase (Group 1 HPM97_RS09925 ENOG4107543 (lipo)polysaccharide HPM97_RS09930 ENOG4106AH0 Glycosyl Transferase HPM97_RS09935 ENOG4105X1N Glycosyl transferase family 8 HPM97_RS09945 ENOG4105X1N Glycosyl transferase family 8 HPM97_RS09950 ENOG4105K64 Glycosyl transferase, family 2 HPM97_RS09955 ENOG41068PG O-Antigen polymerase HPM97_RS09960 ENOG4105D16 lipopolysaccharide heptosyltransferase i HPM97_RS09965 ENOG4105XA0 heptosyltransferase ii HPM97_RS09975 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HPM97_RS09985 ENOG4105K64 Glycosyl transferase, family 2 HPM97_RS09990 ENOG4105PXI polysaccharide deacetylase HPM97_RS09995 ENOG41063SB peptidase HPM97_RS10005 ENOG4107YZP Rhodanese domain protein HPM97_RS10010 ENOG4105VW4 glutaredoxin 3 HPM97_RS10025 ENOG4105D7W serine acetyltransferase HPM97_RS10030 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HPM97_RS10040 ENOG41073TP transcriptional regulator HPM97_RS10045 ENOG4105DAA L-lactate HPM97_RS10055 ENOG4108WY4 inner membrane lipoprotein HPM97_RS10060 ENOG4108YYI Protein of unknown function (DUF2810) HPM97_RS10065 ENOG41060ND LF82 chromosome, complete sequence HPM97_RS10070 ENOG4105E61 Mannitol repressor protein HPM97_RS10080 ENOG4105CTS PTS system mannitol-specific HPM97_RS10085 ENOG4105FP6 Protein of unknown function (DUF3302) HPM97_RS10090 ENOG4105EFX secretion protein, HlyD family HPM97_RS10135 ENOG4108BMY protease HPM97_RS10140 ENOG4108U78 Glutathione S-transferase HPM97_RS10150 ENOG4105EM7 Selenocysteine-specific translation elongation factor HPM97_RS10155 ENOG4105C0A alcohol dehydrogenase HPM97_RS10165 ENOG4105C26 Dehydrogenase HPM97_RS10180 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HPM97_RS10190 ENOG4105CT4 transporter HPM97_RS10200 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HPM97_RS10205 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HPM97_RS10210 ENOG4105H6Q decarboxylase HPM97_RS10215 ENOG4105CMG Carbohydrate kinase HPM97_RS10220 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPM97_RS10225 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPM97_RS10230 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HPM97_RS10235 ENOG4108R66 Conserved Protein HPM97_RS10245 ENOG4105J4Q Transcriptional regulator HPM97_RS10250 ENOG4108XIB electron transport protein ysaA HPM97_RS10255 ENOG4105JKW Valine--pyruvate aminotransferase HPM97_RS10260 ENOG4107T9C Alpha amylase catalytic region HPM97_RS10265 ENOG4108UR8 BAX protein HPM97_RS10270 ENOG4105T16 Transcriptional regulator (AraC family) HPM97_RS10275 ENOG4108HWW ABC transporter HPM97_RS10280 ENOG4105C2J ABC transporter HPM97_RS10285 ENOG4105DFW ABC transporter HPM97_RS10295 ENOG4105CMG Carbohydrate kinase HPM97_RS10300 ENOG410688U Inner membrane protein yiaB HPM97_RS10305 ENOG4108Z12 YiaAB two helix domain-containing protein HPM97_RS10310 ENOG4105MEV Acyl-transferase HPM97_RS10335 ENOG41060TC Hok gef cell toxic protein HPM97_RS10345 ENOG4105MVF Transcriptional regulator HPM97_RS10350 ENOG4106JH6 (LipO)protein HPM97_RS10360 ENOG4108ZG0 Ompa motb domain protein HPM97_RS10365 ENOG4107QY8 reductase HPM97_RS10370 ENOG4105HNP -acetyltransferase HPM97_RS10375 ENOG4108R3E Dna-3-methyladenine glycosylase i HPM97_RS10380 ENOG4105EAX Putative lipase HPM97_RS10385 ENOG4105FCD Major Facilitator HPM97_RS10390 ENOG4105DIJ Phosphoethanolamine transferase HPM97_RS10400 ENOG4105DEF Extracellular solute-binding protein, family 5 HPM97_RS10405 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPM97_RS10410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPM97_RS10415 ENOG4105C3U ABC transporter HPM97_RS10420 ENOG4108JQ7 (ABC) transporter HPM97_RS10425 ENOG4105C44 Serine transporter HPM97_RS10450 ENOG4105D1V cellulose synthase operon protein YhjU HPM97_RS10455 ENOG4105WQA Cellulose biosynthesis protein BcsF HPM97_RS10460 ENOG4105U74 cellulose biosynthesis protein BcsE HPM97_RS10465 ENOG410661M cytoplasmic protein HPM97_RS10475 ENOG4107QZ7 Cellulose synthase catalytic subunit HPM97_RS10480 ENOG4107EEX Cellulose synthase regulator protein HPM97_RS10485 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HPM97_RS10490 ENOG4105EJG cellulose synthase HPM97_RS10495 ENOG4105BZU Histidine kinase HPM97_RS10505 ENOG4105CS0 peptidase HPM97_RS10510 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HPM97_RS10515 ENOG4105CMB EAL domain-containing protein HPM97_RS10520 ENOG41066T0 asmA family HPM97_RS10525 ENOG4105CSH Transporter HPM97_RS10530 ENOG4107H3J ribonuclease HPM97_RS10535 ENOG4105CBN LysR family transcriptional regulator HPM97_RS10540 ENOG4106S2D Transcriptional regulator HPM97_RS10550 ENOG4105CA0 peroxidase HPM97_RS10555 ENOG4105CVK Glutamate decarboxylase HPM97_RS10570 ENOG4105BZS acriflavin resistance protein HPM97_RS10575 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPM97_RS10585 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HPM97_RS10590 ENOG4108YK4 Acid-resistance membrane protein HPM97_RS10595 ENOG41060V2 Acid-resistance protein HPM97_RS10600 ENOG4105XXV Acid-resistance protein HPM97_RS10605 ENOG4105KT7 mgtC SapB transporter HPM97_RS10610 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HPM97_RS10615 ENOG4105EHG Permease protein HPM97_RS10625 ENOG41090JE Utilization Protein HPM97_RS10630 ENOG4105D4P Coproporphyrinogen iii oxidase HPM97_RS10640 ENOG4107ENK receptor HPM97_RS10645 ENOG4106QJH hemin transport protein HPM97_RS10655 ENOG4105Y4Z Outer Membrane Lipoprotein HPM97_RS10675 ENOG4105K89 arsenate reductase HPM97_RS10680 ENOG4107R5R arsenical pump membrane protein HPM97_RS10685 ENOG4105KBH arsR family transcriptional regulator HPM97_RS10695 ENOG4105DC8 reductase HPM97_RS10700 ENOG4105D6S protein involved in catabolism of external DNA HPM97_RS10705 ENOG4105DGW oligopeptidase A HPM97_RS10715 ENOG4105DUX Transporter HPM97_RS10730 ENOG4105CJ3 phosphate transporter HPM97_RS10735 ENOG4105CBX hi0933 family HPM97_RS10740 ENOG4107UNS conserved inner membrane protein HPM97_RS10755 ENOG4105D0S secretion protein (HlyD HPM97_RS10760 ENOG4105CJ1 ABC, transporter HPM97_RS10765 ENOG4105CMI transporter HPM97_RS10785 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HPM97_RS10790 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HPM97_RS10795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPM97_RS10800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPM97_RS10805 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HPM97_RS10810 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HPM97_RS10815 ENOG4105DSF transport protein HPM97_RS10820 ENOG4105F9N Major Facilitator Superfamily HPM97_RS10825 ENOG4108W1V Lipoprotein HPM97_RS10830 ENOG4105EX9 Membrane HPM97_RS10850 ENOG4107FS9 Membrane HPM97_RS10860 ENOG4105MG3 Membrane HPM97_RS10865 ENOG4106H78 methyltransferase HPM97_RS10870 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HPM97_RS10875 ENOG4105CAK Cell division ATP-binding protein ftsE HPM97_RS10880 ENOG4105CRP Part of the ABC transporter FtsEX involved in HPM97_RS10885 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPM97_RS10890 ENOG4105CP9 extracellular ligand-binding receptor HPM97_RS10895 ENOG4105U59 -acetyltransferase HPM97_RS10900 ENOG4105CP9 extracellular ligand-binding receptor HPM97_RS10905 ENOG4105C32 Amino acid ABC transporter (Permease) HPM97_RS10910 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPM97_RS10915 ENOG4105C0Z ABC transporter HPM97_RS10920 ENOG4108IV0 ABC, transporter HPM97_RS10925 ENOG4105BZ7 extracellular solute-binding protein family 1 HPM97_RS10930 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HPM97_RS10935 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HPM97_RS10940 ENOG4108IJ9 (ABC) transporter HPM97_RS10945 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HPM97_RS10950 ENOG4105WC8 Conserved Protein HPM97_RS10955 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPM97_RS10975 ENOG4105GMB type VI secretion system effector, hcp1 family HPM97_RS10980 ENOG4105WCN acetyltransferase HPM97_RS10985 ENOG4105D9R oxidoreductase HPM97_RS10990 ENOG4105C2I pirin domain protein HPM97_RS10995 ENOG4105DIQ Transcriptional regulator HPM97_RS11000 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HPM97_RS11005 ENOG4105C6Z Gluconate HPM97_RS11010 ENOG4105C9U ATP-dependent DNA helicase RecQ HPM97_RS11020 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HPM97_RS11025 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPM97_RS11030 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HPM97_RS11050 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HPM97_RS11070 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HPM97_RS11085 ENOG4105E98 transcriptional regulator DeoR family HPM97_RS11090 ENOG4105CYB regulatoR HPM97_RS11095 ENOG4105E0Y RtcB Protein HPM97_RS11110 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HPM97_RS11115 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HPM97_RS11120 ENOG4105C6Z Gluconate HPM97_RS11130 ENOG4105MJ2 Competence protein HPM97_RS11140 ENOG4105DNE Transposase HPM97_RS11150 ENOG4105CE1 Ferrous iron transport protein b HPM97_RS11155 ENOG4105XFK Ferrous iron transport protein A HPM97_RS11160 ENOG4105BZM domain protein HPM97_RS11165 ENOG4108RRZ Transcription elongation factor GreB HPM97_RS11175 ENOG4105E0F Histidine kinase HPM97_RS11195 ENOG4108MAJ Membrane HPM97_RS11205 ENOG4105VEJ Heat shock protein HPM97_RS11210 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HPM97_RS11215 ENOG4105DQY intracellular growth attenuator HPM97_RS11220 ENOG4107RK2 ADP-ribose diphosphatase NudE HPM97_RS11225 ENOG4108JQC penicillin-binding protein 1A HPM97_RS11230 ENOG4108U1Q Pilus assembly protein HPM97_RS11235 ENOG41065NF Fimbrial assembly family protein HPM97_RS11240 ENOG4105XPX DNA utilization protein HofO HPM97_RS11245 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HPM97_RS11250 ENOG4105E4G Type IV pilus HPM97_RS11265 ENOG4105EGB membrane protein DamX HPM97_RS11270 ENOG4105DFE Dna adenine methylase HPM97_RS11275 ENOG4105DJV ribulose-phosphate 3-epimerase HPM97_RS11280 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPM97_RS11285 ENOG4105C31 Tryptophanyl-tRNA synthetase HPM97_RS11290 ENOG4108M21 HPM97_RS11295 ENOG4105RMW regulation of transcription, DNA-dependent HPM97_RS11300 ENOG4108626 Racemase HPM97_RS11305 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HPM97_RS11310 ENOG41080QX K07048 phosphotriesterase-related protein HPM97_RS11315 ENOG4105MUZ Protein of unknown function DUF2620 HPM97_RS11320 ENOG4106M0N transport system permease protein HPM97_RS11325 ENOG4106PKC pyridoxal phosphate binding HPM97_RS11330 ENOG4105VYH HPM97_RS11340 ENOG4107V9H nitrite transporter HPM97_RS11345 ENOG4105WZK nitrite reductase NADPH small subunit HPM97_RS11350 ENOG4107QZF nitrite reductase NADPH large subunit HPM97_RS11360 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HPM97_RS11370 ENOG4105MZU cell filamentation protein HPM97_RS11375 ENOG4105DDQ anthranilate synthase HPM97_RS11380 ENOG4105C8Y Acetylornithine aminotransferase HPM97_RS11385 ENOG410613R integral membrane protein, YccS YhfK family HPM97_RS11395 ENOG4108UKZ OsmC family HPM97_RS11400 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HPM97_RS11410 ENOG4105DNZ Alpha Beta Hydrolase HPM97_RS11415 ENOG4105C5H ABC transporter HPM97_RS11430 ENOG4105VKU nucleicacid-binding protein HPM97_RS11435 ENOG4108YZY peptidylprolyl cis-trans isomerase HPM97_RS11445 ENOG4108V1T peptidylprolyl cis-trans isomerase HPM97_RS11450 ENOG4105WWK YheO domain protein HPM97_RS11460 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HPM97_RS11490 ENOG4105W53 bacterioferritin-associated ferredoxin HPM97_RS11495 ENOG4108UQY Iron-storage protein HPM97_RS11520 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HPM97_RS11565 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HPM97_RS11610 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPM97_RS11615 ENOG41067V7 50S ribosomal protein L36 HPM97_RS11645 ENOG4105VTS DnaJ-like, subfamily C HPM97_RS11650 ENOG4105W1Y Transcriptional regulator HPM97_RS11655 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HPM97_RS11665 ENOG4105C1A potassium transporter peripheral membrane HPM97_RS11685 ENOG4105C79 DNA protecting protein DprA HPM97_RS11695 ENOG4108WI1 Dna topoisomerase HPM97_RS11710 ENOG4105SG3 Protein of unknown function (DUF1488) HPM97_RS11715 ENOG4108Z0R Transferase HPM97_RS11755 ENOG4105CDA abc transporter atp-binding protein HPM97_RS11760 ENOG4105DRP amino acid AbC transporter HPM97_RS11765 ENOG4105EZ7 amino acid ABC transporter HPM97_RS11775 ENOG4105XCM membrane LIPOPROTEIN HPM97_RS11780 ENOG4105BZS acriflavin resistance protein HPM97_RS11785 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPM97_RS11790 ENOG4108XG4 DNA-binding transcriptional regulator HPM97_RS11795 ENOG41061ME transport protein HPM97_RS11800 ENOG4105CEC DNA methylase N-4 N-6 HPM97_RS11810 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPM97_RS11820 ENOG4108IA2 Sodium pantothenate symporter HPM97_RS11825 ENOG4105RG0 Membrane HPM97_RS11830 ENOG4107UEK pfkb domain protein HPM97_RS11835 ENOG4105E98 transcriptional regulator DeoR family HPM97_RS11840 ENOG4105D2N Aldolase HPM97_RS11845 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPM97_RS11850 ENOG4105C2J ABC transporter HPM97_RS11855 ENOG4105CNN ABC, transporter HPM97_RS11860 ENOG4107UEK pfkb domain protein HPM97_RS11870 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPM97_RS11875 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HPM97_RS11880 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HPM97_RS11885 ENOG41062P1 Diguanylate cyclase phosphodiesterase HPM97_RS11895 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HPM97_RS11900 ENOG4105VQ7 Rod shape-determining protein MreD HPM97_RS11910 ENOG4105C03 ribonuclease HPM97_RS11915 ENOG4105QD6 exported protein HPM97_RS11920 ENOG4105D1U peptidase U62 modulator of DNA gyrase HPM97_RS11925 ENOG4105CR8 Transcriptional regulator HPM97_RS11930 ENOG4105ZQC membrane protein AaeX HPM97_RS11945 ENOG4105UNR (Barnase) inhibitor HPM97_RS11950 ENOG4105RID UPF0379 protein yhcN HPM97_RS11965 ENOG4105C0H protease HPM97_RS11970 ENOG4105C0H protease HPM97_RS11975 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HPM97_RS11980 ENOG4105D6Z AFG1 family ATPase HPM97_RS12000 ENOG4107MKT Stringent starvation protein a HPM97_RS12005 ENOG4105KB2 stringent starvation protein b HPM97_RS12010 ENOG4105CEE C4-dicarboxylate transporter HPM97_RS12040 ENOG4108R66 Conserved Protein HPM97_RS12045 ENOG4105DFS Conserved Protein HPM97_RS12050 ENOG4105BZ8 glutamate synthase HPM97_RS12055 ENOG4105CBC glutamate synthase HPM97_RS12060 ENOG4105N5T Radical SAM Protein HPM97_RS12065 ENOG4105BZU Histidine kinase HPM97_RS12070 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HPM97_RS12080 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HPM97_RS12085 ENOG41080Z8 PHOSPHOCARRIER protein HPM97_RS12095 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HPM97_RS12100 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HPM97_RS12105 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPM97_RS12110 ENOG4108IUZ ABC transporter HPM97_RS12115 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HPM97_RS12120 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HPM97_RS12130 ENOG4105C2X Arabinose 5-phosphate isomerase HPM97_RS12135 ENOG4105FEU K -dependent Na -Ca exchanger HPM97_RS12140 ENOG4105DHJ ABC, transporter HPM97_RS12145 ENOG4105CY3 ABC transporter, permease HPM97_RS12150 ENOG4107PE3 Mammalian cell entry related domain protein HPM97_RS12155 ENOG4105E3I toluene tolerance HPM97_RS12160 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HPM97_RS12165 ENOG4105VFK BolA family HPM97_RS12175 ENOG4105HVQ Regulatory factor of maltose metabolism HPM97_RS12180 ENOG4105EAH synthase HPM97_RS12195 ENOG4105QYV Membrane HPM97_RS12205 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HPM97_RS12210 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HPM97_RS12215 ENOG4105HBR Rna-binding protein HPM97_RS12225 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPM97_RS12230 ENOG4105EEI dihydropteroate synthase HPM97_RS12240 ENOG4105NTZ Preprotein translocase subunit SecG HPM97_RS12250 ENOG4105DIJ Phosphoethanolamine transferase HPM97_RS12270 ENOG4105CHV Transcription elongation factor NusA HPM97_RS12310 ENOG4105C1J atp-dependent rna helicase HPM97_RS12315 ENOG4105CIC tryptophan-specific transport protein HPM97_RS12320 ENOG4105DEN Luciferase family HPM97_RS12340 ENOG4108YYD acetyltransferase HPM97_RS12355 ENOG4107R7Y intracellular protease Pfpi family HPM97_RS12360 ENOG4105K4T epimerase HPM97_RS12365 ENOG4107S21 permease HPM97_RS12370 ENOG4105W4M Transport-associated protein HPM97_RS12390 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HPM97_RS12395 ENOG4106HBN Galactosamine-6-phosphate isomerase HPM97_RS12400 ENOG4105F3R pts system mannose fructose sorbose family iid HPM97_RS12405 ENOG4105ETZ PTS System HPM97_RS12410 ENOG4108UZY PTS System HPM97_RS12420 ENOG4105E70 isomerase HPM97_RS12425 ENOG4105CE4 GlcNAc 6-P deacetylase HPM97_RS12430 ENOG4108YTN IIa component HPM97_RS12435 ENOG4105F3R pts system mannose fructose sorbose family iid HPM97_RS12445 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HPM97_RS12455 ENOG4105E98 transcriptional regulator DeoR family HPM97_RS12460 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HPM97_RS12465 ENOG4105ZEG Suppressor protein HPM97_RS12470 ENOG4105CTX dehydratase HPM97_RS12475 ENOG4105DJB Major Facilitator Superfamily HPM97_RS12485 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPM97_RS12490 ENOG4105BZW Glycerate kinase HPM97_RS12515 ENOG410811B TRANSCRIPTIONal HPM97_RS12520 ENOG4105C7B Threonine dehydratase HPM97_RS12525 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HPM97_RS12530 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPM97_RS12535 ENOG4105C6N Formate acetyltransferase HPM97_RS12540 ENOG4105KME endoribonuclease L-psp HPM97_RS12545 ENOG4105EJQ L-serine dehydratase HPM97_RS12550 ENOG4105C44 Serine transporter HPM97_RS12560 ENOG4106D80 Uncharacterized protein YhaL HPM97_RS12565 ENOG4108CNN domain protein HPM97_RS12570 ENOG4105CWB LysR family transcriptional Regulator HPM97_RS12575 ENOG4105KAF membrAne HPM97_RS12580 ENOG4105KAF membrAne HPM97_RS12585 ENOG4105CHF Glutathione S-transferase HPM97_RS12590 ENOG4108VBZ doxx family HPM97_RS12595 ENOG4105YJD HPM97_RS12600 ENOG41090KG Inner membrane protein YqjE HPM97_RS12605 ENOG4105NE1 Conserved Protein HPM97_RS12610 ENOG4105WAY exported protein HPM97_RS12615 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HPM97_RS12620 ENOG4106W5V Membrane HPM97_RS12625 ENOG4107YCY Transcriptional regulator HPM97_RS12650 ENOG4105DPW Major facilitator superfamily MFS_1 HPM97_RS12660 ENOG4105CTX dehydratase HPM97_RS12665 ENOG4105P66 Membrane HPM97_RS12670 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HPM97_RS12675 ENOG4105DU1 integral membrane protein, terc HPM97_RS12680 ENOG4105EE0 oxidoreductase HPM97_RS12685 ENOG4108UB4 uncharacterized protein ygjQ HPM97_RS12690 ENOG4108VKG metal-dependent hydrolase HPM97_RS12700 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPM97_RS12705 ENOG4107WCA isomerase HPM97_RS12710 ENOG4107W6W Conserved Protein HPM97_RS12715 ENOG4105E5D amino acid HPM97_RS12720 ENOG4105FK9 beta-D-galactosidase beta subunit HPM97_RS12725 ENOG4105CNT hydrolase family 2 HPM97_RS12730 ENOG4105CQ4 Transcriptional regulator HPM97_RS12735 ENOG4108Y51 tRNA-binding protein HPM97_RS12745 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HPM97_RS12750 ENOG4105NTW Transcriptional regulator HPM97_RS12755 ENOG4105Q26 Siderophore-interacting protein HPM97_RS12770 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPM97_RS12775 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HPM97_RS12790 ENOG4107QPK )-transporter HPM97_RS12795 ENOG4107GFK fumarate HPM97_RS12800 ENOG4106DSS Tartrate dehydratase subunit alpha HPM97_RS12805 ENOG4105EJC lysr family transcriptional regulator HPM97_RS12815 ENOG4107ZVW dihydroneopterin aldolase HPM97_RS12830 ENOG4106MWK domain protein HPM97_RS12835 ENOG4105I7R Adenylate cyclase HPM97_RS12855 ENOG4107S78 Band 7 protein HPM97_RS12860 ENOG4105PV3 Inner membrane protein yqiJ HPM97_RS12870 ENOG4105W0Z cytoplasmic protein HPM97_RS12890 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HPM97_RS12900 ENOG4108N92 Thiol disulfide Interchange Protein HPM97_RS12905 ENOG4108MR7 Arylsulfotransferase HPM97_RS12910 ENOG4106032 Glutathionylspermidine synthase HPM97_RS12920 ENOG4105DFG type I secretion outer membrane protein HPM97_RS12925 ENOG41087AY ADP-Ribose pyrophosphatase HPM97_RS12930 ENOG4108SX3 cytoplasmic protein HPM97_RS12935 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HPM97_RS12940 ENOG4105IPS esterase HPM97_RS12945 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPM97_RS12955 ENOG4105E0A ABC, transporter HPM97_RS12960 ENOG4105DQ5 transport system permease protein HPM97_RS12965 ENOG4105EHG Permease protein HPM97_RS12975 ENOG4106KNT transcriptional regulator HPM97_RS12980 ENOG4105VRH Antibiotic biosynthesis monooxygenase HPM97_RS12985 ENOG4105NF4 modulator of drug activity HPM97_RS12990 ENOG4105DHQ Histidine kinase HPM97_RS12995 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPM97_RS13000 ENOG4105H4F exported protein HPM97_RS13005 ENOG4105F4I Transcriptional regulator HPM97_RS13010 ENOG4108J59 Extracellular solute-binding protein, family 5 HPM97_RS13015 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPM97_RS13020 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HPM97_RS13025 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HPM97_RS13030 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPM97_RS13040 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPM97_RS13045 ENOG4105DG4 malate L-lactate dehydrogenase HPM97_RS13050 ENOG4105CPQ Dehydrogenase HPM97_RS13055 ENOG4105DEI Mannitol dehydrogenase HPM97_RS13060 ENOG4107YCY Transcriptional regulator HPM97_RS13065 ENOG4105CCT upf0313 protein HPM97_RS13085 ENOG4105ZKC Conserved Protein HPM97_RS13090 ENOG4105CV8 reductase HPM97_RS13095 ENOG4108I6A alcohol dehydrogenase HPM97_RS13100 ENOG4105CF7 AraC family transcriptional regulator HPM97_RS13105 ENOG4108K81 inner membrane protein YghB HPM97_RS13110 ENOG4105C28 cystathionine HPM97_RS13115 ENOG4105CWK Biopolymer transport protein, ExbB HPM97_RS13120 ENOG4108ZZF transport protein (ExbD) HPM97_RS13125 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HPM97_RS13135 ENOG4105CPC Aldo Keto reductase HPM97_RS13145 ENOG410900S Protein of unknown function (DUF2623) HPM97_RS13150 ENOG4105E3S small subunit HPM97_RS13155 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPM97_RS13160 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HPM97_RS13165 ENOG4105DPX Hydrogenase, large subunit HPM97_RS13170 ENOG4108USZ hydrogenase HPM97_RS13175 ENOG4108WGS hydrogenase 2-specific chaperone HPM97_RS13185 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HPM97_RS13190 ENOG4105CYM Glutathione S-transferase HPM97_RS13195 ENOG4106032 Glutathionylspermidine synthase HPM97_RS13200 ENOG4105CJ3 phosphate transporter HPM97_RS13205 ENOG4108GH0 ATP-binding protein yghT HPM97_RS13210 ENOG4108NDC ATP-binding protein yghS HPM97_RS13215 ENOG4106FPV ATP-binding protein YghR HPM97_RS13220 ENOG4108S55 polysaccharide biosynthesis protein HPM97_RS13230 ENOG4108UUE Transcriptional regulator HPM97_RS13235 ENOG4108M8S permease YjgP YjgQ family protein HPM97_RS13245 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HPM97_RS13250 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPM97_RS13260 ENOG4107RCI amp-dependent synthetase and ligase HPM97_RS13270 ENOG4108KWP DNA-binding transcriptional regulator GlcC HPM97_RS13275 ENOG4105CQB FAD linked oxidase domain protein HPM97_RS13280 ENOG4105EU8 FAD linked oxidase domain protein HPM97_RS13285 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPM97_RS13290 ENOG4108ZJF Glcg protein HPM97_RS13295 ENOG4107QP3 malate synthase g HPM97_RS13300 ENOG4105DAA L-lactate HPM97_RS13305 ENOG4105F88 accessory colonization factor AcfD HPM97_RS13310 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HPM97_RS13315 ENOG410765S (LipO)protein HPM97_RS13330 ENOG4107QHF type ii secretion system protein e HPM97_RS13335 ENOG4105D7Q type ii secretion system HPM97_RS13340 ENOG4108VAU general secretion pathway protein G HPM97_RS13350 ENOG4105X5Z General secretion pathway protein I HPM97_RS13370 ENOG4105U1E general secretion pathway protein M HPM97_RS13375 ENOG41090SZ ABC-2 type transporter HPM97_RS13385 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HPM97_RS13395 ENOG4107SJB teichoic acid biosynthesis HPM97_RS13415 ENOG41084CK capsule polysaccharide HPM97_RS13420 ENOG4105E12 capsule polysaccharide HPM97_RS13425 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HPM97_RS13430 ENOG4107V1M polysaccharide export protein HPM97_RS13435 ENOG4105ECX polysaccharide export HPM97_RS13440 ENOG4105C2X Arabinose 5-phosphate isomerase HPM97_RS13450 ENOG4108YXQ IS66 Orf2 family protein HPM97_RS13455 ENOG4105E5H Transposase HPM97_RS13480 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HPM97_RS13495 ENOG4108YGG dna repair protein HPM97_RS13500 ENOG4105MFG Antirestriction protein HPM97_RS13505 ENOG4106H6R UPF0380 protein HPM97_RS13520 ENOG4108PZQ Inner membrane protein YeeR HPM97_RS13525 ENOG4105F4K antigen 43 HPM97_RS13575 ENOG4108YXQ IS66 Orf2 family protein HPM97_RS13580 ENOG4105E5H Transposase HPM97_RS13605 ENOG4105CXN decarboxylase HPM97_RS13610 ENOG4105EAA nucleoside HPM97_RS13625 ENOG4105CEN a g-specific adenine glycosylase HPM97_RS13635 ENOG41090ED Protein with unknown function (DUF469) HPM97_RS13645 ENOG4105K33 Periplasmic Protein HPM97_RS13650 ENOG4105HDK L-asparaginase HPM97_RS13655 ENOG4106MH3 alpha helix chain HPM97_RS13660 ENOG4105CSA Coproporphyrinogen iii oxidase HPM97_RS13665 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HPM97_RS13675 ENOG4108VIA integral membrane protein HPM97_RS13680 ENOG4105DFA alanine racemase domain protein HPM97_RS13685 ENOG4105CZX twitching motility protein HPM97_RS13705 ENOG4105D7Z glutathione synthase HPM97_RS13710 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPM97_RS13715 ENOG4105RWS endonuclease I HPM97_RS13725 ENOG4107QNK )-transporter HPM97_RS13745 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HPM97_RS13760 ENOG4108K0D peptidase, M48 HPM97_RS13765 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPM97_RS13770 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HPM97_RS13775 ENOG4105CTS PTS system mannitol-specific HPM97_RS13780 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HPM97_RS13785 ENOG4108Q8A Fructose-1,6-bisphosphatase HPM97_RS13790 ENOG4108R4K DNA-binding, transcriptional regulator HPM97_RS13800 ENOG4108JJB ABC transporter HPM97_RS13805 ENOG4108JJB ABC transporter HPM97_RS13835 ENOG4105D2N Aldolase HPM97_RS13840 ENOG4105D64 Mechanosensitive ion channel HPM97_RS13845 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HPM97_RS13850 ENOG4105MPN Membrane HPM97_RS13855 ENOG4105DEQ transcriptional regulator HPM97_RS13860 ENOG4105CYC Transferase HPM97_RS13865 ENOG4108M7F enoyl-CoA hydratase isomerase HPM97_RS13870 ENOG4105DJT lAO AO transport system ATPase HPM97_RS13875 ENOG4105D5P Methylmalonyl-coA mutase HPM97_RS13890 ENOG4108JQ1 Dehydrogenase HPM97_RS13900 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HPM97_RS13920 ENOG4107RAQ aminopeptidase HPM97_RS13925 ENOG4105D0A hydroxylase HPM97_RS13930 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HPM97_RS13955 ENOG4105CS2 ec 3.2.1.21 HPM97_RS13960 ENOG4105N5Z UPF0267 protein HPM97_RS13965 ENOG4108UT2 hemolysin iii HPM97_RS13975 ENOG4105Y75 tpr repeat protein HPM97_RS13980 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HPM97_RS13985 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HPM97_RS13990 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPM97_RS13995 ENOG4105T95 Thiol disulfide interChange protein HPM97_RS14000 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HPM97_RS14010 ENOG4105CRK lysyL-tRNA synthetase HPM97_RS14025 ENOG4105C2W permease HPM97_RS14030 ENOG4105BZ8 glutamate synthase HPM97_RS14035 ENOG4108R8B oxidoreductase Fe-S subunit HPM97_RS14040 ENOG4105C7N Xanthine uracil vitamin C permease HPM97_RS14045 ENOG4107QUY Guanine deaminase HPM97_RS14050 ENOG4105C2W permease HPM97_RS14055 ENOG4105C7W Xanthine dehydrogenase HPM97_RS14060 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HPM97_RS14065 ENOG4107UUR Chlorohydrolase aminohydrolase HPM97_RS14070 ENOG4105BZ8 glutamate synthase HPM97_RS14075 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HPM97_RS14080 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HPM97_RS14085 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HPM97_RS14090 ENOG4105C5B carbamate kinase HPM97_RS14100 ENOG4107S4Y M20 DapE family protein YgeY HPM97_RS14105 ENOG4107RCH Diaminopropionate ammonia-lyase HPM97_RS14110 ENOG4105IW6 Carbamoyltransferase HPM97_RS14115 ENOG4108JUB Transcriptional regulator HPM97_RS14120 ENOG4108UTP (2Fe-2S)-binding domain protein HPM97_RS14125 ENOG4108HR6 Dehydrogenase HPM97_RS14130 ENOG4105C7W Xanthine dehydrogenase HPM97_RS14135 ENOG4108K5P (LipO)protein HPM97_RS14145 ENOG4108MHD transport protein HPM97_RS14150 ENOG4105CHU acetyl-coa acetyltransferase HPM97_RS14160 ENOG4105CHR reductase HPM97_RS14165 ENOG4107QNK )-transporter HPM97_RS14175 ENOG4105RQF LysR family Transcriptional regulator HPM97_RS14185 ENOG41060NJ transcriptional regulator HPM97_RS14200 ENOG4105CPC Aldo Keto reductase HPM97_RS14205 ENOG4105SUV lipoprotein YgdR HPM97_RS14210 ENOG4105EE5 Membrane protein terC HPM97_RS14225 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HPM97_RS14240 ENOG4105IPU prepilin peptidase dependent protein A HPM97_RS14245 ENOG4105JCS prepilin peptidase dependent protein HPM97_RS14250 ENOG4105SEN Protein of unknown function (DUF2509) HPM97_RS14255 ENOG4105RVB Prepilin peptidase dependent protein c HPM97_RS14260 ENOG4105DSY exodeoxyribonuclease V, gamma HPM97_RS14265 ENOG4107QXK peptidase HPM97_RS14270 ENOG4107QKA exodeoxyribonuclease V beta HPM97_RS14275 ENOG4107QYX exodeoxyribonuclease v alpha HPM97_RS14280 ENOG4108EKC n-acetylglutamate synthase HPM97_RS14285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPM97_RS14290 ENOG4105CID antiterminator HPM97_RS14295 ENOG4105CI1 PTS System HPM97_RS14300 ENOG4105C87 Aminotransferase class I and II HPM97_RS14305 ENOG4105C2X Arabinose 5-phosphate isomerase HPM97_RS14330 ENOG4105CA3 membrane-bound lytic murein transglycosylase HPM97_RS14335 ENOG4105CUZ uba thif-type nad fad binding protein HPM97_RS14340 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HPM97_RS14345 ENOG4105C9B Cysteine desulfurase HPM97_RS14350 ENOG4105M5B (LipO)protein HPM97_RS14355 ENOG4105ETT transcriptional Regulator, LysR family HPM97_RS14360 ENOG4105M08 Membrane HPM97_RS14370 ENOG4107EDW L-fucose operon activator HPM97_RS14380 ENOG4105CMG Carbohydrate kinase HPM97_RS14385 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HPM97_RS14390 ENOG4105EDR glucose galactose transporter HPM97_RS14395 ENOG4107W7X Aldolase HPM97_RS14400 ENOG4105C0A alcohol dehydrogenase HPM97_RS14410 ENOG4105EJQ L-serine dehydratase HPM97_RS14415 ENOG4105C44 Serine transporter HPM97_RS14420 ENOG4105EWT decarboxylase family HPM97_RS14435 ENOG4105WP7 tRNA pseudouridine synthase C HPM97_RS14440 ENOG4105DR9 pseudouridine synthase HPM97_RS14445 ENOG4105QDK Flavodoxin HPM97_RS14450 ENOG4105DJB Major Facilitator Superfamily HPM97_RS14455 ENOG4105EQX glucarate dehydratase HPM97_RS14460 ENOG4105EQX glucarate dehydratase HPM97_RS14465 ENOG4105BZU Histidine kinase HPM97_RS14470 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPM97_RS14475 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPM97_RS14480 ENOG4106A2Z transcriptional regulator antitoxin, MazE HPM97_RS14485 ENOG4105MZG transcriptional modulator of maze toxin, mazf HPM97_RS14490 ENOG4105DXN mazG family HPM97_RS14505 ENOG4105HA9 of methanol dehydrogenase type HPM97_RS14515 ENOG4105HA9 of methanol dehydrogenase type HPM97_RS14525 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HPM97_RS14530 ENOG4105WBN Transcriptional regulator (LacI family HPM97_RS14555 ENOG4108CWB sugar kinase ygcE HPM97_RS14560 ENOG4108ITV Inner membrane protein yqcE HPM97_RS14565 ENOG4105CHR reductase HPM97_RS14570 ENOG4107R3A FAD linked oxidase domain protein HPM97_RS14575 ENOG4105C54 Major Facilitator superfamily HPM97_RS14580 ENOG4106IKH Electron transfer flavoprotein HPM97_RS14585 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HPM97_RS14590 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HPM97_RS14595 ENOG4105WQV ferredoxin-like protein HPM97_RS14600 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPM97_RS14605 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HPM97_RS14620 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HPM97_RS14625 ENOG4107635 Hok Gef family protein HPM97_RS14630 ENOG4108MXK alkaline phosphatase isozyme conversion HPM97_RS14650 ENOG4105N0Z inner membrane protein ygbE HPM97_RS14685 ENOG4108K5P (LipO)protein HPM97_RS14690 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPM97_RS14700 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HPM97_RS14705 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HPM97_RS14710 ENOG4105KZM cytoplasmic protein HPM97_RS14715 ENOG4105MEW serine threonine protein phosphatase HPM97_RS14730 ENOG4105VXR cytoplasmic protein HPM97_RS14740 ENOG4108JUA Transcriptional regulator HPM97_RS14745 ENOG4105C45 hydrogenase expression formation protein (HypE) HPM97_RS14750 ENOG4105CQS hydrogenase expression formation protein HypD HPM97_RS14755 ENOG41083WG hydrogenase assembly chaperone HPM97_RS14760 ENOG4107RSS Hydrogenase accessory protein HypB HPM97_RS14765 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HPM97_RS14770 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HPM97_RS14775 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HPM97_RS14780 ENOG4107R30 NADH dehydrogenase HPM97_RS14785 ENOG4107TDF Formate hydrogenlyase subunit 4 HPM97_RS14790 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPM97_RS14795 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HPM97_RS14800 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HPM97_RS14805 ENOG4105I6X formate hydrogenlyase maturation HPM97_RS14810 ENOG4108MG9 hydrogenase 3 maturation protease HPM97_RS14820 ENOG4105CS2 ec 3.2.1.21 HPM97_RS14825 ENOG4105C5Y PTS System HPM97_RS14830 ENOG4105DDV Transcriptional regulator (LacI family HPM97_RS14835 ENOG4108RC0 Electron transport protein HPM97_RS14840 ENOG4105C8H hydrogenase maturation protein Hypf HPM97_RS14855 ENOG4108JUA Transcriptional regulator HPM97_RS14865 ENOG410804X Transcriptional regulator HPM97_RS14870 ENOG4105J92 DNA-binding transcriptional activator GutM HPM97_RS14875 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HPM97_RS14880 ENOG4105VI0 Pts system, glucitol sorbitol-specific HPM97_RS14885 ENOG4105DZY Pts system, glucitol sorbitol-specific HPM97_RS14890 ENOG410787A Pts system, glucitol sorbitol-specific HPM97_RS14895 ENOG4105CVE Lytic murein transglycosylase HPM97_RS14900 ENOG4107TH8 cina domain protein HPM97_RS14920 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HPM97_RS14950 ENOG4107VXZ Hydrolase HPM97_RS14955 ENOG4105W39 Membrane HPM97_RS14970 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPM97_RS14975 ENOG4105CW7 secretion protein, HlyD family HPM97_RS14980 ENOG4105NTK Transcriptional repressor Mpra HPM97_RS14985 ENOG4105ZED uncharacterized protein ygaH HPM97_RS14990 ENOG4108UMN azlc family HPM97_RS15000 ENOG4105GIJ Glycine betaine HPM97_RS15005 ENOG4108HQS Glycine betaine HPM97_RS15010 ENOG4108IJ7 Glycine betaine HPM97_RS15015 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPM97_RS15020 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPM97_RS15030 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HPM97_RS15035 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPM97_RS15040 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPM97_RS15045 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HPM97_RS15050 ENOG4108WMJ Protein of unknown function (DUF2002) HPM97_RS15055 ENOG4108RNS Exports L-alanine (By similarity) HPM97_RS15060 ENOG4108X73 DNA- binding protein HPM97_RS15065 ENOG4108V62 Rhodanese domain protein HPM97_RS15070 ENOG41080HT Transcriptional regulator, arsr family HPM97_RS15075 ENOG4105VPI YqaE family transport protein HPM97_RS15080 ENOG4109066 lysm domain bon superfamily protein HPM97_RS15085 ENOG4108PVQ transcriptional regulator HPM97_RS15090 ENOG4105C85 amino acid HPM97_RS15095 ENOG4108JPW Aminotransferase HPM97_RS15100 ENOG4105C26 Dehydrogenase HPM97_RS15105 ENOG4105D5U fad dependent oxidoreductase HPM97_RS15115 ENOG4105E54 alpha-amylase HPM97_RS15140 ENOG4108MGN ATP-binding component of a transport system HPM97_RS15255 ENOG4105DFP Integrase HPM97_RS15270 ENOG4108Z1B Cyclase dehydrase HPM97_RS15280 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPM97_RS15285 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPM97_RS15300 ENOG4108JU6 CBS domain protein HPM97_RS15305 ENOG4106KVJ cytochrome C assembly protein HPM97_RS15310 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HPM97_RS15335 ENOG41090EK ompa motb domain protein HPM97_RS15340 ENOG4108KHX Diguanylate cyclase HPM97_RS15345 ENOG4108WS1 HPM97_RS15350 ENOG4105QP9 Protein of unknown function (DUF2799) HPM97_RS15355 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPM97_RS15360 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HPM97_RS15365 ENOG4105CQC Prephenate dehydratase HPM97_RS15375 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HPM97_RS15380 ENOG4105VNT transposase (IS4 family) protein HPM97_RS15385 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HPM97_RS15390 ENOG4105C34 Pseudouridine synthase HPM97_RS15395 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HPM97_RS15400 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPM97_RS15425 ENOG4105CSH Transporter HPM97_RS15430 ENOG4105T42 (LipO)protein HPM97_RS15435 ENOG4105JIM Phosphatidylserine synthase HPM97_RS15440 ENOG4105CD5 CoA-binding domain protein HPM97_RS15445 ENOG4106IUH DTW domain containing protein HPM97_RS15450 ENOG4105K63 Thioredoxin HPM97_RS15455 ENOG4105EIB trna rrna methyltransferase HPM97_RS15475 ENOG41090KR LysR family transcriptional Regulator HPM97_RS15480 ENOG4105C1J atp-dependent rna helicase HPM97_RS15490 ENOG4108IYU L-aspartate oxidase HPM97_RS15500 ENOG4105EMN RNA polymerase sigma factor HPM97_RS15505 ENOG41069PW sigma-e factor negative regulatory protein HPM97_RS15510 ENOG4105VQK sigma E regulatory protein, MucB RseB HPM97_RS15515 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HPM97_RS15525 ENOG4105C3F Signal peptidase i HPM97_RS15545 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HPM97_RS15560 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HPM97_RS15565 ENOG4106G6Q Transcriptional regulator HPM97_RS15570 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HPM97_RS15575 ENOG4108Z6B deaminase HPM97_RS15585 ENOG4108ETH Formylglycinamide ribotide synthetase HPM97_RS15590 ENOG4107WP9 Histidine kinase HPM97_RS15595 ENOG4108SKK alpha helix protein HPM97_RS15600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPM97_RS15610 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HPM97_RS15620 ENOG4108NZE NAGC-like transcriptional regulator HPM97_RS15625 ENOG4107HQ7 repeat protein HPM97_RS15630 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HPM97_RS15635 ENOG4108F37 ATP-binding component of a transport system HPM97_RS15640 ENOG4105CNN ABC, transporter HPM97_RS15645 ENOG4105CPQ Dehydrogenase HPM97_RS15650 ENOG4108ZKT aldose 1-epimerase HPM97_RS15655 ENOG4108SB3 DoxX Family HPM97_RS15680 ENOG4105FUY alpha subunit HPM97_RS15685 ENOG4108W5M transcriptional regulator HPM97_RS15690 ENOG4105D8G Major Facilitator superfamily HPM97_RS15695 ENOG4108MN2 Stationary phase inducible protein CsiE HPM97_RS15700 ENOG4107XM9 (LipO)protein HPM97_RS15705 ENOG4105ECY inositol monophosphatase HPM97_RS15725 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HPM97_RS15745 ENOG4108ZIT Ferredoxin, 2FE-2S HPM97_RS15750 ENOG4105WVQ Fe-S assembly protein IscX HPM97_RS15760 ENOG4105YYA enhanced serine sensitivity protein SseB HPM97_RS15765 ENOG4105KHC sulfurtransferase HPM97_RS15770 ENOG4105DN3 alpha-2-macroglobulin domain protein HPM97_RS15775 ENOG4108JQB penicillin-binding protein 1C HPM97_RS15805 ENOG4105N21 Membrane HPM97_RS15820 ENOG4105VPD cellular component movement HPM97_RS15845 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPM97_RS15850 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPM97_RS15855 ENOG41066DY Membrane HPM97_RS15860 ENOG4108ZMA Outer membrane lipoprotein HPM97_RS15865 ENOG41062G3 Protein of unknown function (DUF2633) HPM97_RS15875 ENOG4105BZU Histidine kinase HPM97_RS15880 ENOG4105C9X ppx gppa phosphatase HPM97_RS15885 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HPM97_RS15890 ENOG4108V3E phosphoribosylglycinamide formyltransferase HPM97_RS15895 ENOG4105CXB phosphoribosylaminoimidazole synthetase HPM97_RS15905 ENOG4105C2W permease HPM97_RS15910 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HPM97_RS15915 ENOG4105K89 arsenate reductase HPM97_RS15920 ENOG4105ERG peptidase m48, ste24p HPM97_RS15925 ENOG4105C02 permease HPM97_RS15930 ENOG4105TMB Formate nitrite transporter HPM97_RS15935 ENOG4108JUA Transcriptional regulator HPM97_RS15940 ENOG4105I6X formate hydrogenlyase maturation HPM97_RS15945 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HPM97_RS15955 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPM97_RS15960 ENOG4108JPZ Monovalent cation H antiporter subunit D HPM97_RS15965 ENOG4107WQX hydrogenase 4 membrane subunit HPM97_RS15970 ENOG4105D65 subunit l HPM97_RS15975 ENOG4107TDF Formate hydrogenlyase subunit 4 HPM97_RS15980 ENOG4108JPZ Monovalent cation H antiporter subunit D HPM97_RS15985 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HPM97_RS15990 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPM97_RS15995 ENOG4105RH4 Glycine cleavage system transcriptional repressor HPM97_RS16005 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPM97_RS16015 ENOG4105CGZ zinc metallopeptidase HPM97_RS16025 ENOG4106KED esterase YpfH HPM97_RS16040 ENOG4105KUZ arsenate reductase HPM97_RS16050 ENOG4105BZS acriflavin resistance protein HPM97_RS16055 ENOG4105BZU Histidine kinase HPM97_RS16060 ENOG4105BZ8 glutamate synthase HPM97_RS16070 ENOG4108PVD exported protein HPM97_RS16075 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPM97_RS16080 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPM97_RS16085 ENOG4105C6K Malic enzyme HPM97_RS16090 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HPM97_RS16095 ENOG4106S4J ethanolamine utilization protein EutP HPM97_RS16100 ENOG4105NDK ethanolamine utilization protein HPM97_RS16105 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HPM97_RS16110 ENOG4107WUY phosphate acetyltransferase HPM97_RS16115 ENOG4105KNY Microcompartments protein HPM97_RS16120 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HPM97_RS16125 ENOG4108EKI Dehydrogenase HPM97_RS16130 ENOG4107RWI ethanolamine utilization protein eutJ HPM97_RS16135 ENOG4105C0A alcohol dehydrogenase HPM97_RS16140 ENOG4105ENY Ethanolamine utilization protein eutH HPM97_RS16145 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HPM97_RS16150 ENOG4105CPD ethanolamine ammonia-lyase HPM97_RS16160 ENOG4106D67 ethanolamine utilization protein HPM97_RS16165 ENOG4108X49 Ethanolamine utilization protein EutK HPM97_RS16170 ENOG4108K3Z AraC family transcriptional regulator HPM97_RS16180 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HPM97_RS16190 ENOG4105QZU Inner membrane protein YfeZ HPM97_RS16195 ENOG4105E7K (LipO)protein HPM97_RS16200 ENOG4105EZR dyp-type peroxidase family protein HPM97_RS16205 ENOG4107S1E Beta-lactamase HPM97_RS16210 ENOG4105C5Y PTS System HPM97_RS16225 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HPM97_RS16230 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HPM97_RS16235 ENOG4108I5D sulfate abc transporter HPM97_RS16240 ENOG4105ECW sulfate abc transporter HPM97_RS16245 ENOG4108IJ6 ABC transporter HPM97_RS16250 ENOG4105C6T cysteine synthase HPM97_RS16255 ENOG4105M0Y HPM97_RS16265 ENOG4105C5Y PTS System HPM97_RS16270 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPM97_RS16280 ENOG4105C6T cysteine synthase HPM97_RS16300 ENOG4105VRT cytoplasmic protein HPM97_RS16305 ENOG4105DHU Bile acid HPM97_RS16310 ENOG4108M0I Transcriptional regulator HPM97_RS16315 ENOG4108NFH Sugar hydrolase HPM97_RS16320 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HPM97_RS16325 ENOG4105EAA nucleoside HPM97_RS16335 ENOG4105CN8 Transcriptional regulator HPM97_RS16375 ENOG4105GXM Putative transcription regulator (DUF1323) HPM97_RS16380 ENOG4105HZG regulatoR HPM97_RS16395 ENOG4108KMM Diguanylate cyclase HPM97_RS16400 ENOG4105D9N nucleoside HPM97_RS16410 ENOG4109076 Conserved Protein HPM97_RS16425 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HPM97_RS16430 ENOG410863U PTS System HPM97_RS16435 ENOG4105DC7 peptidase M24 HPM97_RS16440 ENOG4105CN9 Peptidase m42 family protein HPM97_RS16445 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPM97_RS16450 ENOG4108CIP transcriptional regulator HPM97_RS16455 ENOG4105DY9 regulatoR HPM97_RS16460 ENOG4108HRK Histidine kinase HPM97_RS16465 ENOG4105CHM Aminotransferase HPM97_RS16475 ENOG4105D1S lipid A biosynthesis HPM97_RS16480 ENOG4105W9M Membrane HPM97_RS16490 ENOG4108V08 YfdX protein HPM97_RS16500 ENOG4105CFN oxalyl-CoA decarboxylase HPM97_RS16505 ENOG4108N2Y auxin Efflux HPM97_RS16510 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPM97_RS16515 ENOG4105BZU Histidine kinase HPM97_RS16520 ENOG4108WQH regulatoR HPM97_RS16525 ENOG4105CW7 secretion protein, HlyD family HPM97_RS16530 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPM97_RS16545 ENOG4105W8I Transcriptional regulator HPM97_RS16550 ENOG4108W9T type 1 fimbriae regulatory protein HPM97_RS16555 ENOG4108W9T type 1 fimbriae regulatory protein HPM97_RS16595 ENOG4105C6F GntR Family Transcriptional Regulator HPM97_RS16645 ENOG4105CPQ Dehydrogenase HPM97_RS16650 ENOG4108I5G Major Facilitator superfamily HPM97_RS16680 ENOG4107QRT dEAD DEAH box helicase HPM97_RS16705 ENOG4105DFP Integrase HPM97_RS16715 ENOG4105S64 Formate nitrite transporter HPM97_RS16720 ENOG410903C (LipO)protein HPM97_RS16730 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HPM97_RS16735 ENOG4105KZW UPF0381 protein HPM97_RS16750 ENOG4108BY2 phosphohistidine phosphatase HPM97_RS16760 ENOG4106PG1 outer membrane usher protein HPM97_RS16765 ENOG4108FZ9 Chaperone HPM97_RS16770 ENOG4105NEV Fimbrial HPM97_RS16775 ENOG4105UGQ Fimbrial HPM97_RS16780 ENOG4105US4 fimbrial-like protein yfcP HPM97_RS16805 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HPM97_RS16810 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HPM97_RS16820 ENOG4105EJ9 Membrane HPM97_RS16825 ENOG4108BPE -transporting atpase HPM97_RS16830 ENOG4105MH2 YfcL protein HPM97_RS16840 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPM97_RS16845 ENOG4105F9N Major Facilitator Superfamily HPM97_RS16850 ENOG4106WZ1 flagella biosynthesis regulator HPM97_RS16860 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPM97_RS16870 ENOG4105DQR SNARE associated Golgi HPM97_RS16880 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPM97_RS16885 ENOG4108S3P Sporulation domain protein HPM97_RS16890 ENOG4105E96 Colicin v production protein HPM97_RS16895 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HPM97_RS16900 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HPM97_RS16905 ENOG4105E89 ABC transporter HPM97_RS16910 ENOG4105E89 ABC transporter HPM97_RS16915 ENOG4105DSP amino acid AbC transporter HPM97_RS16920 ENOG4106YG3 ABC transporter HPM97_RS16925 ENOG4108JEH abc transporter atp-binding protein HPM97_RS16930 ENOG4105DNE Transposase HPM97_RS16940 ENOG4105DFD Na H antiporter HPM97_RS16945 ENOG4105ECP epimerase HPM97_RS16950 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HPM97_RS16955 ENOG4105CYM Glutathione S-transferase HPM97_RS16960 ENOG4108SHQ Glutathione S-transferase HPM97_RS16965 ENOG4108RE9 Phosphodiesterase HPM97_RS16970 ENOG4105PTV Nudix Hydrolase HPM97_RS16975 ENOG4105CSX c4-dicarboxylate anaerobic carrier HPM97_RS16980 ENOG4105C6K Malic enzyme HPM97_RS16985 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPM97_RS16995 ENOG4105XWI UPF0304 protein HPM97_RS17000 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HPM97_RS17005 ENOG4107QWE )-transporter HPM97_RS17015 ENOG4105CHM Aminotransferase HPM97_RS17020 ENOG4107NQ8 LysR family Transcriptional regulator HPM97_RS17040 ENOG4105GKE subunit e HPM97_RS17045 ENOG4107QIZ NADH dehydrogenase HPM97_RS17050 ENOG4108IEH NADH dehydrogenase subunit g HPM97_RS17065 ENOG4107UFS subunit j HPM97_RS17075 ENOG4105D65 subunit l HPM97_RS17080 ENOG4105C8S subunit m HPM97_RS17090 ENOG4105GDX Domain of unknown function (DUF1877) HPM97_RS17110 ENOG4107YB6 acetyltransferase, (GNAT) family HPM97_RS17115 ENOG4105TNS Conserved Protein HPM97_RS17120 ENOG4105E4F Isochorismate synthase HPM97_RS17135 ENOG4108IPT Naphthoate synthase HPM97_RS17145 ENOG4105CEY Amp-dependent synthetase and ligase HPM97_RS17150 ENOG4106GZG polymyxin resistance protein B HPM97_RS17200 ENOG4108UII YfaZ family HPM97_RS17210 ENOG4107258 Transcriptional regulator HPM97_RS17220 ENOG4105CSP Major Facilitator Superfamily HPM97_RS17235 ENOG4105DNE Transposase HPM97_RS17240 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPM97_RS17250 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HPM97_RS17255 ENOG4105CXY transporter HPM97_RS17260 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HPM97_RS17265 ENOG4105GZI Transcriptional regulator HPM97_RS17270 ENOG4105CZM Major Facilitator HPM97_RS17275 ENOG4105FQR PH-inducible protein involved in stress response HPM97_RS17280 ENOG4105XPH Ferredoxin HPM97_RS17285 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPM97_RS17290 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPM97_RS17295 ENOG4107GHC outer membrane autotransporter HPM97_RS17305 ENOG4105DRR Transcriptional regulator, GntR family HPM97_RS17315 ENOG4105CXK mandelate racemase muconate lactonizing HPM97_RS17320 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPM97_RS17325 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HPM97_RS17330 ENOG4108QJJ Protein of unknown function (DUF1175) HPM97_RS17335 ENOG4107S52 alpha-2-macroglobulin domain protein HPM97_RS17340 ENOG41081SK signal peptide protein HPM97_RS17345 ENOG4105EDV vault protein HPM97_RS17350 ENOG4105CHU acetyl-coa acetyltransferase HPM97_RS17355 ENOG4105CRW Short chain fatty acid transporter HPM97_RS17360 ENOG4107QNJ CoA-transferase subunit B HPM97_RS17365 ENOG4107QP7 CoA-transferase subunit A HPM97_RS17370 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPM97_RS17375 ENOG4105BZU Histidine kinase HPM97_RS17380 ENOG4105BZU Histidine kinase HPM97_RS17385 ENOG41068CG regulatoR HPM97_RS17390 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HPM97_RS17395 ENOG4105FCK Membrane HPM97_RS17400 ENOG4105CJ2 (LipO)protein HPM97_RS17405 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPM97_RS17410 ENOG4105CF1 Alkylated DNA repair protein HPM97_RS17415 ENOG4105IBP Cyclic peptide transporter HPM97_RS17430 ENOG4108ZNS ferredoxin-type protein NapF HPM97_RS17435 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HPM97_RS17445 ENOG4108BGM Quinol dehydrogenase periplasmic component HPM97_RS17450 ENOG4105GXZ Ferredoxin-type protein NapH HPM97_RS17455 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HPM97_RS17460 ENOG4105CUW cytochrome C-TYPE protein HPM97_RS17465 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HPM97_RS17470 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HPM97_RS17475 ENOG41060IM Heme exporter protein HPM97_RS17480 ENOG4105X3C heme exporter protein HPM97_RS17490 ENOG4105DA4 cytochrome c-type biogenesis protein HPM97_RS17495 ENOG4107QX9 Thiol disulfide interChange protein HPM97_RS17500 ENOG4105KWW Biogenesis protein HPM97_RS17505 ENOG4105WH1 Two component transcriptional regulator luxr family HPM97_RS17510 ENOG4108MGN ATP-binding component of a transport system HPM97_RS17520 ENOG4105E68 Sulfatase HPM97_RS17540 ENOG4105CFI type iii restriction protein res subunit HPM97_RS17545 ENOG4105I08 Pseudouridine synthase HPM97_RS17550 ENOG4105C2C drug resistance transporter, Bcr CflA HPM97_RS17555 ENOG4105HG6 HPM97_RS17560 ENOG4108JQ5 ABC transporter HPM97_RS17565 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HPM97_RS17570 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HPM97_RS17575 ENOG4105E43 Extracellular solute-binding protein, family 5 HPM97_RS17580 ENOG4105CXC rtn protein HPM97_RS17585 ENOG4107TT5 NLP P60 protein HPM97_RS17590 ENOG41076MN Phosphoesterase, PA-phosphatase related HPM97_RS17595 ENOG4105CKI cobalamin synthesis protein HPM97_RS17600 ENOG4105DEI Mannitol dehydrogenase HPM97_RS17610 ENOG4105KRS Proteinase inhibitor HPM97_RS17615 ENOG4105S8Q sugar efflux transporter HPM97_RS17620 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HPM97_RS17625 ENOG4105DE4 1-phosphofructokinase HPM97_RS17630 ENOG4105DM4 PTS System HPM97_RS17635 ENOG4105DD7 kinase (PfkB family HPM97_RS17640 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HPM97_RS17645 ENOG4105D9N nucleoside HPM97_RS17650 ENOG4108Y4K DNA-binding transcriptional activator HPM97_RS17660 ENOG4105D9N nucleoside HPM97_RS17665 ENOG4105DD7 kinase (PfkB family HPM97_RS17675 ENOG4105HMI Membrane HPM97_RS17680 ENOG4105DUM transcriptional regulator, lysR family HPM97_RS17685 ENOG4108IQI permease HPM97_RS17690 ENOG4105D05 Receptor HPM97_RS17695 ENOG4105CXY transporter HPM97_RS17700 ENOG4105EAC phosphoserine phosphatase HPM97_RS17705 ENOG4105EJQ L-serine dehydratase HPM97_RS17715 ENOG4105C4W S-formylglutathione hydrolase HPM97_RS17725 ENOG4105DHF Membrane HPM97_RS17730 ENOG41060NJ transcriptional regulator HPM97_RS17735 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HPM97_RS17740 ENOG4105C2J ABC transporter HPM97_RS17745 ENOG4108HWV )-transporter HPM97_RS17750 ENOG4107SJI Dehydrogenase HPM97_RS17755 ENOG4105BZ8 glutamate synthase HPM97_RS17760 ENOG4105Y9N Membrane HPM97_RS17765 ENOG4107GZ4 SanA protein HPM97_RS17775 ENOG41067MG lrgb family HPM97_RS17785 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HPM97_RS17790 ENOG4105EQR Transposase IS116 IS110 IS902 HPM97_RS17795 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPM97_RS17800 ENOG4105CPB ATP-dependent endonuclease of the OLD family HPM97_RS17805 ENOG4108MJ5 VirK protein HPM97_RS17810 ENOG4105DJY efflux transporter, rnd family, mfp subunit HPM97_RS17815 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPM97_RS17820 ENOG4105VEQ Cold shock protein HPM97_RS17830 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPM97_RS17840 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HPM97_RS17850 ENOG4108JJ8 (ABC) transporter HPM97_RS17855 ENOG4108JJ9 ABC, transporter HPM97_RS17860 ENOG4105C3M thioredoxin reductase HPM97_RS17870 ENOG4105CNU cell division protein FtsK HPM97_RS17880 ENOG4105D1H recombination factor protein RarA HPM97_RS17890 ENOG4107QY8 reductase HPM97_RS17895 ENOG4105QAX Iron-sulfur HPM97_RS17900 ENOG4107KGK dmso reductase anchor subunit HPM97_RS17905 ENOG4105CHJ isochorismatase hydrolase HPM97_RS17915 ENOG4105E5D amino acid HPM97_RS17920 ENOG410642W LysR family Transcriptional regulator HPM97_RS17925 ENOG4108X0B nad(p)h dehydrogenase (quinone) HPM97_RS17930 ENOG4105F1A Pyruvate formate-lyase HPM97_RS17935 ENOG4105C6N Formate acetyltransferase HPM97_RS17940 ENOG4105TMB Formate nitrite transporter HPM97_RS17945 ENOG4105DDY UPF0142 protein ycaO HPM97_RS17950 ENOG4107VMU Membrane HPM97_RS17965 ENOG4108K0D peptidase, M48 HPM97_RS17975 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HPM97_RS17985 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HPM97_RS17990 ENOG4105BZ1 (ABC) transporter HPM97_RS18000 ENOG4105T0Z Conserved Protein HPM97_RS18015 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HPM97_RS18020 ENOG4107S90 membrAne HPM97_RS18025 ENOG4106371 Methyltransferase HPM97_RS18035 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HPM97_RS18045 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HPM97_RS18050 ENOG4105EAQ (twin-arginine translocation) pathway signal HPM97_RS18055 ENOG4105C5X domain protein HPM97_RS18060 ENOG4105CGF Aromatic amino acid aminotransferase HPM97_RS18065 ENOG4105FCK Membrane HPM97_RS18080 ENOG4105CD8 aminopeptidase N HPM97_RS18085 ENOG4105E2Y ABC, transporter HPM97_RS18090 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPM97_RS18100 ENOG4105GVF (ABC) transporter HPM97_RS18105 ENOG4108UZX fmn reductase HPM97_RS18110 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HPM97_RS18115 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HPM97_RS18120 ENOG4105CW0 outer membrane usher protein HPM97_RS18125 ENOG4108MDY Fimbrial HPM97_RS18130 ENOG4105Q7J Fimbrial HPM97_RS18135 ENOG4105MX3 Fimbrial HPM97_RS18140 ENOG4106PH7 chaperone HPM97_RS18150 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HPM97_RS18155 ENOG4105QVC MOSC domain-containing protein HPM97_RS18165 ENOG4105C5H ABC transporter HPM97_RS18170 ENOG4105F1S paraquat-inducible protein a HPM97_RS18175 ENOG4105DY2 Paraquat-inducible protein b HPM97_RS18180 ENOG4108Q2G (LipO)protein HPM97_RS18185 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HPM97_RS18195 ENOG4105DAN ATP-dependent protease HPM97_RS18205 ENOG4105UYK outer membrane protein a HPM97_RS18215 ENOG4108RZ1 DNA transformation protein HPM97_RS18220 ENOG4105EM2 membrane HPM97_RS18225 ENOG410901E Membrane HPM97_RS18230 ENOG41088T4 Helicase IV HPM97_RS18245 ENOG4105K4P CoA-binding domain protein HPM97_RS18260 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HPM97_RS18265 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HPM97_RS18270 ENOG4108MN8 Membrane HPM97_RS18280 ENOG4105E3S small subunit HPM97_RS18285 ENOG4105DPX Hydrogenase, large subunit HPM97_RS18290 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HPM97_RS18295 ENOG4108USZ hydrogenase HPM97_RS18300 ENOG4108VXY Hydrogenase-1 operon protein HyaE HPM97_RS18305 ENOG4105MVP hydrogenase-1 operon protein HyaF HPM97_RS18310 ENOG4105C4M (Ubiquinol oxidase) subunit I HPM97_RS18315 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPM97_RS18325 ENOG4105D6F Phosphatase HPM97_RS18330 ENOG41060EU Cold shock-like protein HPM97_RS18335 ENOG4105VEQ Cold shock protein HPM97_RS18350 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HPM97_RS18355 ENOG4105HEE Binding Domain protein HPM97_RS18360 ENOG4105BZU Histidine kinase HPM97_RS18365 ENOG4108SV3 Tmao reductase system periplasmic protein tort HPM97_RS18370 ENOG4106WF9 DNA-binding transcriptional regulator TorR HPM97_RS18375 ENOG4105CUW cytochrome C-TYPE protein HPM97_RS18380 ENOG4107QY8 reductase HPM97_RS18405 ENOG4105D6F Phosphatase HPM97_RS18410 ENOG4105XH3 HPM97_RS18420 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HPM97_RS18425 ENOG4105C2W permease HPM97_RS18450 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HPM97_RS18460 ENOG4108R86 Transcriptional regulator HPM97_RS18465 ENOG4105C26 Dehydrogenase HPM97_RS18475 ENOG4105CK7 Sodium proline symporter HPM97_RS18490 ENOG4105DBE peroxidase HPM97_RS18495 ENOG4105D5M phosphate starvation-inducible protein HPM97_RS18505 ENOG4105CND Glycosyl transferase, family 2 HPM97_RS18510 ENOG4107BJW polysaccharide deacetylase HPM97_RS18515 ENOG4108TUY outer membrane protein PgaA HPM97_RS18520 ENOG4105BZU Histidine kinase HPM97_RS18530 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HPM97_RS18540 ENOG4107XHZ cytoplasmic chaperone TorD family protein HPM97_RS18545 ENOG4108UQ5 membrane protein YcdZ HPM97_RS18550 ENOG4105P8Q Curli production assembly transport component CsgG HPM97_RS18555 ENOG4108WYR Curli production assembly transport component, CsgF HPM97_RS18560 ENOG4108XDW curli assembly protein CsgE HPM97_RS18565 ENOG41086KC Transcriptional regulator HPM97_RS18570 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HPM97_RS18575 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HPM97_RS18590 ENOG4108UVJ appr-1-p processing domain protein HPM97_RS18595 ENOG4107RZC phospholipase d HPM97_RS18610 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HPM97_RS18615 ENOG4105NAC (LipO)protein HPM97_RS18620 ENOG4108W47 Acidic protein msyB HPM97_RS18630 ENOG4105D1S lipid A biosynthesis HPM97_RS18640 ENOG4108YYC ycei family HPM97_RS18645 ENOG4105DS1 cytochrome b561 HPM97_RS18650 ENOG4106974 biofilm formation HPM97_RS18655 ENOG4105F76 Sarcosine oxidase HPM97_RS18660 ENOG4105PVA Biofilm formation regulatory protein BssS HPM97_RS18665 ENOG4105MEA DNA damage-inducible protein i HPM97_RS18675 ENOG4105F3T (LipO)protein HPM97_RS18680 ENOG4105E9S glutaredoxin 2 HPM97_RS18690 ENOG4105D9U N-acetyltransferase HPM97_RS18700 ENOG4105EP9 oxidoreductase HPM97_RS18705 ENOG4105CJR Integral membrane protein (MviN HPM97_RS18710 ENOG4105QVD Flagella synthesis protein FlgN HPM97_RS18715 ENOG4105M9M anti-sigma28 factor FlgM HPM97_RS18720 ENOG4105CKS Flagella basal body P-ring formation protein flgA HPM97_RS18725 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HPM97_RS18730 ENOG4108ZC9 flagellar basal-body rod protein flgc HPM97_RS18735 ENOG4105W00 Flagellar hook capping protein HPM97_RS18740 ENOG4105BZE flagellar hook protein, FlgE HPM97_RS18745 ENOG4108KPB Flagellar basal-body rod protein FlgF HPM97_RS18750 ENOG4105CGA flagellar basal-body rod protein FlgG HPM97_RS18765 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HPM97_RS18770 ENOG4105E1Q flagellar hook-associated protein HPM97_RS18775 ENOG4105DTJ flagellar hook-associated protein HPM97_RS18790 ENOG4107QQB Ribonuclease E HPM97_RS18795 ENOG4105EI2 Pseudouridine synthase HPM97_RS18800 ENOG4108UHJ MAF-like protein HPM97_RS18805 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HPM97_RS18825 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HPM97_RS18830 ENOG4105CHR reductase HPM97_RS18835 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPM97_RS18840 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPM97_RS18845 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HPM97_RS18850 ENOG4105HHA aminodeoxychorismate lyase HPM97_RS18860 ENOG4107QRG dna polymerase iii HPM97_RS18865 ENOG4105F8V Hydrolase, tatD family HPM97_RS18870 ENOG4105CI1 PTS System HPM97_RS18875 ENOG4105CNM Receptor HPM97_RS18880 ENOG4105K59 histidine triad (HIT) protein HPM97_RS18885 ENOG41090DQ Lipoprotein HPM97_RS18890 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HPM97_RS18910 ENOG4105CEP NADH dehydrogenase HPM97_RS18915 ENOG4107MBR 17 kDa surface antigen HPM97_RS18920 ENOG4108IND Tetr family transcriptional regulator HPM97_RS18925 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HPM97_RS18930 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPM97_RS18935 ENOG4108JA2 transcriptioN-repair coupling factor HPM97_RS18940 ENOG4105IQC Inner membrane protein YcfT HPM97_RS18945 ENOG4105D60 lipoprotein releasing system transmembrane protein HPM97_RS18950 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPM97_RS18955 ENOG4105D60 lipoprotein releasing system transmembrane protein HPM97_RS18965 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HPM97_RS18980 ENOG4107RUE extracellular solute-binding protein family 1 HPM97_RS18985 ENOG4105D38 putrescine abc transporter HPM97_RS18995 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPM97_RS19005 ENOG4105EZE Cupin 4 family protein HPM97_RS19010 ENOG4105IFJ Histidine kinase HPM97_RS19015 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPM97_RS19020 ENOG4107QTF adenylosuccinate lyase HPM97_RS19045 ENOG4108HMX isocitrate dehydrogenase (NADP) HPM97_RS19065 ENOG41064WM Uncharacterized protein YcgX HPM97_RS19070 ENOG4108XDN Transcriptional regulator HPM97_RS19075 ENOG4105BZU Histidine kinase HPM97_RS19080 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HPM97_RS19085 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HPM97_RS19095 ENOG410738I uncharacterized protein ymgC HPM97_RS19100 ENOG4105BZU Histidine kinase HPM97_RS19115 ENOG410658X HPM97_RS19155 ENOG4107QMS site-determining protein HPM97_RS19165 ENOG4105S66 prophage protein HPM97_RS19170 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HPM97_RS19180 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HPM97_RS19190 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HPM97_RS19195 ENOG4105KT5 UmuD protein HPM97_RS19200 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPM97_RS19205 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HPM97_RS19220 ENOG4105ED1 spovr family HPM97_RS19230 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPM97_RS19250 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPM97_RS19260 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HPM97_RS19275 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPM97_RS19280 ENOG4108BSC Methyltransferase HPM97_RS19285 ENOG4105E0A ABC, transporter HPM97_RS19290 ENOG4105EHG Permease protein HPM97_RS19295 ENOG4105S10 periplasmic binding protein HPM97_RS19305 ENOG4105VDH Dihydroxyacetone kinase HPM97_RS19310 ENOG4108UTZ Dihydroxyacetone kinase HPM97_RS19315 ENOG4105CMT Dihydroxyacetone kinase HPM97_RS19320 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HPM97_RS19330 ENOG4105C3G gtp-binding protein HPM97_RS19340 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HPM97_RS19345 ENOG4105CHH sulfate transporter HPM97_RS19350 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HPM97_RS19375 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPM97_RS19380 ENOG4108YY7 Invasion gene expression up-regulator SirB HPM97_RS19385 ENOG41063JG Transcriptional regulator HPM97_RS19410 ENOG4105EWV Sodium calcium exchanger membrane region HPM97_RS19415 ENOG4105WS7 Cation transport regulator HPM97_RS19420 ENOG4108NH8 Cation transport protein HPM97_RS19425 ENOG41090EX DsrE family HPM97_RS19430 ENOG4105ID0 Putative invasin HPM97_RS19435 ENOG4105WH1 Two component transcriptional regulator luxr family HPM97_RS19440 ENOG4105BZU Histidine kinase HPM97_RS19445 ENOG4105DQQ Major facilitator superfamily MFS_1 HPM97_RS19450 ENOG4105CRU nitrate reductase, alpha subunit HPM97_RS19455 ENOG4108IUE nitrate reductase beta subunit HPM97_RS19460 ENOG4105R3A Nitrate reductase HPM97_RS19465 ENOG41076YT nitrate reductase, gamma subunit HPM97_RS19495 ENOG4105CIY formyltetrahydrofolate deformylase HPM97_RS19505 ENOG4105D78 K07001 NTE family protein HPM97_RS19510 ENOG4105I93 response regulator HPM97_RS19515 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPM97_RS19520 ENOG4108SAU DNA-binding protein H-ns HPM97_RS19525 ENOG4107104 thymidine kinase HPM97_RS19530 ENOG4105VNT transposase (IS4 family) protein HPM97_RS19535 ENOG4105C0A alcohol dehydrogenase HPM97_RS19540 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HPM97_RS19550 ENOG4108J59 Extracellular solute-binding protein, family 5 HPM97_RS19555 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPM97_RS19560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPM97_RS19565 ENOG4105C3U ABC transporter HPM97_RS19570 ENOG4108JQ7 (ABC) transporter HPM97_RS19590 ENOG4107SVH Potassium channel protein HPM97_RS19595 ENOG4105K9H YciI-like protein HPM97_RS19600 ENOG410822N TonB family HPM97_RS19605 ENOG4105NAU thioesterase Superfamily protein HPM97_RS19625 ENOG4105EIF outer membrane protein W HPM97_RS19630 ENOG4108N8X transition metal ion binding HPM97_RS19635 ENOG4108Z9Z response to DNA damage stimulus HPM97_RS19655 ENOG4105DK0 Indole-3-glycerol phosphate synthase HPM97_RS19660 ENOG4108EFP Anthranilate synthase component II HPM97_RS19665 ENOG4105CRQ synthase (Component I) HPM97_RS19675 ENOG4105DB7 PHP domain protein HPM97_RS19680 ENOG4107RTD sua5 ycio yrdc ywlc family protein HPM97_RS19685 ENOG4105EG3 transmembrane signal peptide protein HPM97_RS19690 ENOG4105FE9 pseudouridine synthase HPM97_RS19705 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HPM97_RS19710 ENOG4105UBK short-chain dehydrogenase reductase HPM97_RS19715 ENOG4105ERU peptidase HPM97_RS19720 ENOG4105RKX Protein of unknown function (DUF2498) HPM97_RS19725 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPM97_RS19730 ENOG4107R11 Transcriptional regulator HPM97_RS19750 ENOG4107QM5 aconitate hydratase HPM97_RS19760 ENOG4105EYK Phosphatidylglycerophosphatase B HPM97_RS19765 ENOG4105Q4A inner membrane protein yciS HPM97_RS19770 ENOG4105CFV Tetratricopeptide repeat protein HPM97_RS19780 ENOG4108ZJT translation initiation factor, Sui1 HPM97_RS19790 ENOG4105N2W Transcriptional regulator HPM97_RS19795 ENOG410643D UPF0509 protein HPM97_RS19800 ENOG4105BZU Histidine kinase HPM97_RS19815 ENOG4105Q4T oxidoreductase HPM97_RS19820 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HPM97_RS19825 ENOG41067SE Tetr family transcriptional regulator HPM97_RS19830 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPM97_RS19835 ENOG4105BZS acriflavin resistance protein HPM97_RS19840 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPM97_RS19845 ENOG4105C2C drug resistance transporter, Bcr CflA HPM97_RS19850 ENOG4108JQ2 peptide transport system atp-binding protein HPM97_RS19855 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HPM97_RS19860 ENOG4108EU3 peptide transport system, permease HPM97_RS19865 ENOG4108I5W peptide transport system, permease protein HPM97_RS19870 ENOG4108HIY periplasmic HPM97_RS19875 ENOG4105N0E Protein of unknown function (DUF2543) HPM97_RS19880 ENOG4105CUB amino acid HPM97_RS19890 ENOG4105CFQ glutamine synthetase HPM97_RS19895 ENOG4108Z86 Glutamine amidotransferase HPM97_RS19900 ENOG4107VRI Transcriptional regulator HPM97_RS19905 ENOG4105C26 Dehydrogenase HPM97_RS19910 ENOG4105CJP fad dependent oxidoreductase HPM97_RS19915 ENOG4108JPW Aminotransferase HPM97_RS19920 ENOG4105E51 psp operon transcriptional activator HPM97_RS19925 ENOG41087YS Phage shock protein A HPM97_RS19930 ENOG4105YYT phage shock protein B HPM97_RS19935 ENOG4105FM1 phage shock protein C HPM97_RS19940 ENOG4105NNG Peripheral inner membrane phage-shock protein HPM97_RS19945 ENOG4105K8Z Phage shock protein HPM97_RS19950 ENOG4107QW3 Sucrose phosphorylase HPM97_RS19955 ENOG4105WEM extracellular solute-binding protein HPM97_RS19960 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HPM97_RS19965 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HPM97_RS19970 ENOG4107RRD Dehydrogenase HPM97_RS19975 ENOG4107TYA transient receptor potential locus HPM97_RS19980 ENOG4105CK5 oxidoreductase HPM97_RS19985 ENOG4105C71 hydrolase family 65, central catalytic HPM97_RS19990 ENOG4107URF beta-phospho-glucomutase HPM97_RS19995 ENOG4108IJ9 (ABC) transporter HPM97_RS20000 ENOG4107EFV Outer membrane protein G HPM97_RS20005 ENOG4105FKQ transcriptional regulator HPM97_RS20010 ENOG4105CM6 amino acid regulated cytosolic protein HPM97_RS20020 ENOG4108JU8 Transcriptional regulator HPM97_RS20025 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HPM97_RS20030 ENOG4107S8C mandelate racemase muconate lactonizing HPM97_RS20035 ENOG4105KXI murein peptide amidase A HPM97_RS20040 ENOG4107QSI ABC, transporter HPM97_RS20045 ENOG4105D64 Mechanosensitive ion channel HPM97_RS20050 ENOG4105S5I Membrane HPM97_RS20055 ENOG4105Q9Y Universal stress protein HPM97_RS20060 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HPM97_RS20065 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPM97_RS20070 ENOG4105CFC Transporter HPM97_RS20075 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HPM97_RS20080 ENOG4105CH2 amidohydrolase HPM97_RS20085 ENOG4106KR7 LysR family Transcriptional regulator HPM97_RS20090 ENOG4108DG9 Smr protein MutS2 HPM97_RS20095 ENOG4105BZU Histidine kinase HPM97_RS20105 ENOG4105C1J atp-dependent rna helicase HPM97_RS20115 ENOG4108RW8 Universal stress protein F HPM97_RS20120 ENOG4105FCK Membrane HPM97_RS20125 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HPM97_RS20130 ENOG4105IKK cytoplasmic protein HPM97_RS20135 ENOG41090X5 Heat shock protein hslJ HPM97_RS20140 ENOG4105C5I Dehydrogenase HPM97_RS20145 ENOG4107H52 Dicarboxylate transport HPM97_RS20150 ENOG410689M (LipO)protein HPM97_RS20155 ENOG4105WXT Conserved Protein HPM97_RS20160 ENOG4108WFR AraC Family Transcriptional Regulator HPM97_RS20165 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HPM97_RS20170 ENOG4108Z0R Transferase HPM97_RS20175 ENOG4107S5I aldo keto reductase HPM97_RS20185 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HPM97_RS20190 ENOG4108HPI phosphatidate Cytidylyltransferase HPM97_RS20195 ENOG4105E8V Alpha Beta Hydrolase Fold protein HPM97_RS20200 ENOG41077RS Phosphatase HPM97_RS20210 ENOG4105CQ7 ATP-dependent helicase HPM97_RS20215 ENOG4107DB1 DUF218 domain HPM97_RS20220 ENOG4105C26 Dehydrogenase HPM97_RS20225 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPM97_RS20230 ENOG4105CPW cytochrome b561 HPM97_RS20235 ENOG4105UPP uncharacterized protein ydcA HPM97_RS20240 ENOG4107NK6 Hok/gef family HPM97_RS20250 ENOG4105C8Q Methyl-accepting chemotaxis HPM97_RS20255 ENOG4105DDW LysR family Transcriptional regulator HPM97_RS20260 ENOG4105E32 cytoplasmic protein HPM97_RS20270 ENOG4105Z2P Protein of unknown function (DUF465) HPM97_RS20275 ENOG4108Z9I -acetyltransferase HPM97_RS20280 ENOG4107WE3 acetyltransferase YdcK HPM97_RS20285 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HPM97_RS20290 ENOG41088CC tellurite resistance protein tehB HPM97_RS20295 ENOG4108KKZ (LipO)protein HPM97_RS20305 ENOG4105D7V transposase HPM97_RS20310 ENOG4105DKK Benzoate HPM97_RS20315 ENOG4108JCI Transcriptional regulator HPM97_RS20320 ENOG4105CFP Peptidase U32 HPM97_RS20325 ENOG4105RR0 Protein of unknown function (DUF2554) HPM97_RS20335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPM97_RS20340 ENOG4107TYH extracellular solute-binding protein family 1 HPM97_RS20345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPM97_RS20350 ENOG4105D81 ABC transporter, permease HPM97_RS20355 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HPM97_RS20370 ENOG410654E Membrane HPM97_RS20375 ENOG4105R71 cytoplasmic protein HPM97_RS20380 ENOG4108T9Y Inner membrane protein ydcZ HPM97_RS20385 ENOG4108Z7F N-acetyltransferase HPM97_RS20390 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HPM97_RS20395 ENOG4108WYP Transcriptional regulator HPM97_RS20400 ENOG4105CHB tonB-dependent Receptor HPM97_RS20405 ENOG4108NS2 receptor HPM97_RS20410 ENOG4105C85 amino acid HPM97_RS20415 ENOG4108N27 Glutathione S-transferase HPM97_RS20425 ENOG4105EUZ Beta-lactamase domain protein HPM97_RS20435 ENOG4108MEJ flavin reductase domain protein HPM97_RS20440 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HPM97_RS20450 ENOG4105JAB phenazine biosynthesis protein, phzf family HPM97_RS20455 ENOG4105D0D Nitrate reductase 2, gamma subunit HPM97_RS20460 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HPM97_RS20465 ENOG4108IUE nitrate reductase beta subunit HPM97_RS20470 ENOG4105CRU nitrate reductase, alpha subunit HPM97_RS20475 ENOG4107QND Nitrite extrusion protein HPM97_RS20480 ENOG4108UI3 Leucine Rich repeat HPM97_RS20485 ENOG4108UI3 Leucine Rich repeat HPM97_RS20495 ENOG4105RPH Inner membrane protein YddG HPM97_RS20505 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPM97_RS20510 ENOG4108MG3 formate dehydrogenase HPM97_RS20515 ENOG41084S7 Plasmid maintenance system antidote protein HPM97_RS20525 ENOG4105DQ4 alcohol dehydrogenase HPM97_RS20535 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HPM97_RS20540 ENOG4105TPS biofilm-dependent modulation protein HPM97_RS20545 ENOG4108Z9K Osmotically inducible protein HPM97_RS20550 ENOG4107H6U ABC transporter HPM97_RS20555 ENOG4105C3U ABC transporter HPM97_RS20560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPM97_RS20565 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPM97_RS20570 ENOG4105DEF Extracellular solute-binding protein, family 5 HPM97_RS20575 ENOG4108UQS dipeptidase HPM97_RS20580 ENOG4105BZU Histidine kinase HPM97_RS20595 ENOG4105F32 YngK protein HPM97_RS20600 ENOG4105E5D amino acid HPM97_RS20605 ENOG4105CVK Glutamate decarboxylase HPM97_RS20610 ENOG4107RAN Peptidase, M16 HPM97_RS20615 ENOG4105PE1 Receptor HPM97_RS20620 ENOG4105CQ0 ABC transporter HPM97_RS20630 ENOG4105C4X radical SAM domain protein HPM97_RS20635 ENOG4105ENH Sulfatase HPM97_RS20650 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HPM97_RS20655 ENOG4106PIH fimbrial-like protein ydeQ HPM97_RS20660 ENOG4106318 fimbrial-like protein YdeR HPM97_RS20665 ENOG4108WDE Fimbrial protein HPM97_RS20670 ENOG4105CW0 outer membrane usher protein HPM97_RS20675 ENOG4108NAE Fimbrial chaperone protein HPM97_RS20680 ENOG4108RQP Major type 1 subunit fimbrin HPM97_RS20700 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HPM97_RS20735 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HPM97_RS20745 ENOG4105FFC UPF0187 protein HPM97_RS20755 ENOG4105BZU Histidine kinase HPM97_RS20760 ENOG4105M0C cytoplasmic protein HPM97_RS20765 ENOG4105CSV Glutaminase HPM97_RS20770 ENOG4105C26 Dehydrogenase HPM97_RS20775 ENOG4105EGI Transcriptional regulator HPM97_RS20795 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HPM97_RS20800 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HPM97_RS20805 ENOG4106DNR multiple antibiotic resistance protein HPM97_RS20810 ENOG4105CS2 ec 3.2.1.21 HPM97_RS20820 ENOG4105VCP PTS System HPM97_RS20835 ENOG4105FDP GntR family transcriptional regulator HPM97_RS20840 ENOG4108594 Permease of the drug metabolite transporter HPM97_RS20845 ENOG4105E5W Transporter HPM97_RS20865 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HPM97_RS20870 ENOG4108YDI single-species biofilm formation on inanimate substrate HPM97_RS20875 ENOG4105DGW oligopeptidase A HPM97_RS20880 ENOG4105EMU Dehydrogenase HPM97_RS20885 ENOG4107XBN GntR Family Transcriptional Regulator HPM97_RS20890 ENOG41061EV selenium-binding protein YdfZ HPM97_RS20895 ENOG4105DEI Mannitol dehydrogenase HPM97_RS20905 ENOG4105CPQ Dehydrogenase HPM97_RS20910 ENOG4105CXK mandelate racemase muconate lactonizing HPM97_RS20925 ENOG4108MK9 spermidine N(1)-acetyltransferase HPM97_RS20935 ENOG4105KBG Protein of unknown function (DUF1161) HPM97_RS20940 ENOG4107QY8 reductase HPM97_RS20945 ENOG4105C3J Cysteine desulfurase HPM97_RS20950 ENOG4105QAX Iron-sulfur HPM97_RS20955 ENOG4107KGK dmso reductase anchor subunit HPM97_RS20960 ENOG4108NEM leader-binding protein dmsD HPM97_RS20970 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPM97_RS20975 ENOG4105DAG ROK family HPM97_RS20980 ENOG4106NZI LysR family Transcriptional regulator HPM97_RS20985 ENOG4105D94 Major Facilitator Superfamily HPM97_RS21000 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HPM97_RS21015 ENOG4105DSF transport protein HPM97_RS21020 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPM97_RS21025 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPM97_RS21030 ENOG4105C5D exported protein HPM97_RS21035 ENOG4105D5Q Arginine ornithine antiporter HPM97_RS21045 ENOG4105RA2 Membrane HPM97_RS21050 ENOG4107EXC regulatoR HPM97_RS21055 ENOG4105JJR Histidine kinase HPM97_RS21065 ENOG4105C9Q fumarate hydratase class II HPM97_RS21070 ENOG4107GFK fumarate HPM97_RS21075 ENOG4105EIP mannose-6-phosphate isomerase HPM97_RS21080 ENOG4106J39 exported protein HPM97_RS21085 ENOG4108QNI outer membrane porin protein HPM97_RS21090 ENOG4105CT4 transporter HPM97_RS21095 ENOG4105CNT hydrolase family 2 HPM97_RS21100 ENOG4105XEA Tetr family transcriptional regulator HPM97_RS21105 ENOG4107ZQV short-chain dehydrogenase reductase HPM97_RS21110 ENOG4107P2S Transcriptional regulator HPM97_RS21115 ENOG4105CI1 PTS System HPM97_RS21120 ENOG4105C87 Aminotransferase class I and II HPM97_RS21130 ENOG4105D9R oxidoreductase HPM97_RS21135 ENOG4106C6R beta-lactam resistance protein HPM97_RS21140 ENOG4105QZ5 OriC-binding nucleoid-associated protein HPM97_RS21145 ENOG4105M9B inner membrane protein ydgK HPM97_RS21170 ENOG4108UQQ Electron transport complex HPM97_RS21180 ENOG4105CSM endonuclease III HPM97_RS21185 ENOG4105DUX Transporter HPM97_RS21190 ENOG4108K3A Glutathione S-transferase HPM97_RS21195 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HPM97_RS21210 ENOG410642K Lysozyme inhibitor HPM97_RS21220 ENOG4108XTF Outer Membrane Lipoprotein HPM97_RS21235 ENOG4105Y49 secretion protein, HlyD family HPM97_RS21240 ENOG4105DSW Fusaric acid resistance protein HPM97_RS21245 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPM97_RS21250 ENOG4107RGM aldo keto reductase HPM97_RS21255 ENOG4105XZD Fe-S protein HPM97_RS21260 ENOG4108WUH Transcriptional regulator, TetR family HPM97_RS21265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPM97_RS21270 ENOG4108UYE Lactoylglutathione lyase HPM97_RS21280 ENOG4107QRT dEAD DEAH box helicase HPM97_RS21285 ENOG4105M2J Glutaredoxin HPM97_RS21290 ENOG4105K4H Nlp p60 protein HPM97_RS21295 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPM97_RS21300 ENOG4105F27 Major Facilitator HPM97_RS21315 ENOG4105F52 Transcriptional regulator HPM97_RS21320 ENOG4105CZQ inner membrane transport protein YdhC HPM97_RS21325 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPM97_RS21330 ENOG4108R6K riboflavin synthase, subunit alpha HPM97_RS21355 ENOG4105N0V mono-oxygenase ydhR HPM97_RS21360 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HPM97_RS21365 ENOG4108Y7C Conserved Protein HPM97_RS21370 ENOG4108NWD Cytochrome HPM97_RS21375 ENOG4108393 oxidoreductase Fe-S subunit HPM97_RS21380 ENOG4105JVW HPM97_RS21385 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HPM97_RS21390 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HPM97_RS21395 ENOG4105RFR Protein of unknown function (DUF2767) HPM97_RS21400 ENOG4105CA9 Pyruvate kinase HPM97_RS21405 ENOG4105KMX major outer membrane lipoprotein HPM97_RS21410 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPM97_RS21425 ENOG4105JRK feS assembly protein SufD HPM97_RS21430 ENOG4105C3K feS assembly ATPase SufC HPM97_RS21435 ENOG4105DIW FeS assembly protein SUFB HPM97_RS21440 ENOG4108Z4V iron-sulfur cluster assembly HPM97_RS21445 ENOG410671Z uncharacterized protein ydiH HPM97_RS21450 ENOG4105KA0 thioesterase Superfamily protein HPM97_RS21455 ENOG4105CQB FAD linked oxidase domain protein HPM97_RS21460 ENOG4105IPI Membrane HPM97_RS21470 ENOG4105SUA Ydil protein HPM97_RS21475 ENOG4105EMV Major Facilitator HPM97_RS21480 ENOG4105EMV Major Facilitator HPM97_RS21495 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HPM97_RS21500 ENOG4105C1G acyl-Coa dehydrogenase HPM97_RS21505 ENOG4105W4W Transcriptional regulator HPM97_RS21510 ENOG4105CV7 Electron transfer flavoprotein HPM97_RS21515 ENOG4105C10 Electron transfer flavoprotein HPM97_RS21520 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPM97_RS21525 ENOG41090P5 ferredoxin-like protein HPM97_RS21530 ENOG4105CEY Amp-dependent synthetase and ligase HPM97_RS21535 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPM97_RS21545 ENOG4105C5I Dehydrogenase HPM97_RS21550 ENOG4107QPK )-transporter HPM97_RS21555 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPM97_RS21565 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPM97_RS21580 ENOG4108TC0 Diguanylate phosphodiesterase HPM97_RS21585 ENOG4108QBX (LipO)protein HPM97_RS21595 ENOG4108V06 Glutathione peroxidase HPM97_RS21630 ENOG41082NX 50s ribosomal protein l35 HPM97_RS21635 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HPM97_RS21655 ENOG4108NE3 Salt-induced outer membrane protein HPM97_RS21660 ENOG4105DE4 1-phosphofructokinase HPM97_RS21665 ENOG4105P10 Uncharacterized protein ydiZ HPM97_RS21675 ENOG4107PN8 YfeABCD locus regulator HPM97_RS21680 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HPM97_RS21685 ENOG4107K5X Membrane-bound metal-dependent hydrolase HPM97_RS21690 ENOG4108ETY sodium dicarboxylate symporter HPM97_RS21705 ENOG4105CH6 catalase HPM97_RS21710 ENOG410901P UPF0249 protein HPM97_RS21715 ENOG4105F8D glycoside hydrolase family 4 HPM97_RS21720 ENOG4105EZV Transcriptional regulator HPM97_RS21725 ENOG4105VCP PTS System HPM97_RS21730 ENOG4105CK1 PTS System HPM97_RS21735 ENOG4105VZJ PTS System HPM97_RS21740 ENOG4105KKI DNA-binding transcriptional activator OsmE HPM97_RS21750 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HPM97_RS21760 ENOG4108SPG Periplasmic Protein HPM97_RS21770 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HPM97_RS21790 ENOG4105CGK Exodeoxyribonuclease III HPM97_RS21795 ENOG4108RSN SNARE associated Golgi HPM97_RS21800 ENOG4108KCW iron-sulfur cluster binding HPM97_RS21805 ENOG4108N5C SNARE associated Golgi protein-related protein HPM97_RS21810 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPM97_RS21815 ENOG4105VNH ABC transporter solute-binding protein HPM97_RS21820 ENOG4105CXZ ABC transporter, permease HPM97_RS21825 ENOG4108VGW abc transporter atp-binding protein HPM97_RS21830 ENOG4107RM6 sulfurtransferase HPM97_RS21835 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HPM97_RS21840 ENOG4105M6F mutator MutT protein HPM97_RS21845 ENOG4105MTM Protein of unknown function (DUF1496) HPM97_RS21850 ENOG4105D82 Glutamate dehydrogenase HPM97_RS21855 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPM97_RS21860 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HPM97_RS21865 ENOG41069NU Nitroreductase HPM97_RS21870 ENOG4105D07 Signal peptide peptidase, SppA HPM97_RS21875 ENOG4105HDK L-asparaginase HPM97_RS21880 ENOG4108RWI nicotinamidase HPM97_RS21885 ENOG4108KUU Inner membrane metabolite transport protein ydjE HPM97_RS21890 ENOG4105E98 transcriptional regulator DeoR family HPM97_RS21895 ENOG4105CPC Aldo Keto reductase HPM97_RS21900 ENOG4107UH8 sugar kinase HPM97_RS21905 ENOG4105D2N Aldolase HPM97_RS21910 ENOG4105CPQ Dehydrogenase HPM97_RS21915 ENOG4107TE1 transport protein HPM97_RS21920 ENOG4105CPQ Dehydrogenase HPM97_RS21925 ENOG4105VUT cytoplasmic protein HPM97_RS21935 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPM97_RS21940 ENOG4105DSB aldose 1-epimerase HPM97_RS21945 ENOG4105CV8 reductase HPM97_RS21950 ENOG4105GNX MltA-interacting MipA family protein HPM97_RS21955 ENOG4105CYN Serine protein kinase HPM97_RS21965 ENOG4106KTS Inner membrane protein yeaI HPM97_RS21970 ENOG4108KHP Diguanylate cyclase HPM97_RS21975 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HPM97_RS21990 ENOG4105R1U AraC Family Transcriptional Regulator HPM97_RS21995 ENOG4105DJ2 Major Facilitator Superfamily HPM97_RS22000 ENOG4105K78 MarR family Transcriptional regulator HPM97_RS22005 ENOG4105UCG Domain of unknown function (DUF333) HPM97_RS22010 ENOG410620I Diguanylate cyclase HPM97_RS22015 ENOG4106G4W HPM97_RS22025 ENOG4105Y3U Transglycosylase-associated protein HPM97_RS22030 ENOG4105YP6 Domain of unknown function (DUF1869) HPM97_RS22035 ENOG4108YS1 cytoplasmic protein HPM97_RS22045 ENOG4105EJC lysr family transcriptional regulator HPM97_RS22050 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPM97_RS22055 ENOG4105C94 Transporter HPM97_RS22060 ENOG4105DVW rieske (2Fe-2S) HPM97_RS22065 ENOG4105E3J oxidoreductase HPM97_RS22070 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HPM97_RS22075 ENOG4105CEY Amp-dependent synthetase and ligase HPM97_RS22080 ENOG4105Y4Z Outer Membrane Lipoprotein HPM97_RS22085 ENOG41072GX Peptidase M22 Glycoprotease HPM97_RS22090 ENOG4105DVT helicase HPM97_RS22095 ENOG4105M4H endoribonuclease L-psp HPM97_RS22100 ENOG4105V2F Uncharacterized protein yoac HPM97_RS22110 ENOG4105CRQ synthase (Component I) HPM97_RS22115 ENOG4105P8F nudix hydrolase HPM97_RS22120 ENOG4105EJQ L-serine dehydratase HPM97_RS22125 ENOG4107XTP (EAL) domain protein HPM97_RS22130 ENOG4105EE5 Membrane protein terC HPM97_RS22135 ENOG4105DAS pts system HPM97_RS22140 ENOG4105ETZ PTS System HPM97_RS22145 ENOG4105F3R pts system mannose fructose sorbose family iid HPM97_RS22160 ENOG4105DHI Methyltransferase HPM97_RS22175 ENOG4105Q3Y exported protein HPM97_RS22185 ENOG4105TIK HPM97_RS22190 ENOG4105J4Q Transcriptional regulator HPM97_RS22195 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPM97_RS22205 ENOG4105CN1 protease HPM97_RS22215 ENOG4108ZGC gaf domain protein HPM97_RS22220 ENOG4105H2K paraquat-inducible protein a HPM97_RS22225 ENOG4105DY2 Paraquat-inducible protein b HPM97_RS22235 ENOG4105WT8 Protein of unknown function (DUF1480) HPM97_RS22240 ENOG4105UVW uncharacterized protein yebW HPM97_RS22245 ENOG4108R1E Serine threonine protein phosphatase 1 HPM97_RS22250 ENOG4105NKT exported protein HPM97_RS22255 ENOG4108PNC copper resistance HPM97_RS22260 ENOG4105FXM Copper resistance protein HPM97_RS22265 ENOG4105MPK DNA polymerase III subunit theta HPM97_RS22270 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPM97_RS22275 ENOG4105UMD exodeoxyribonuclease X HPM97_RS22280 ENOG4105CUG Oligopeptidase b HPM97_RS22285 ENOG4108Q2J Inner membrane protein YebE HPM97_RS22295 ENOG4105X2V dna damage-inducible protein HPM97_RS22305 ENOG4108UHU Aldolase HPM97_RS22310 ENOG4105C01 Dihydroxy-acid dehydratase HPM97_RS22315 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HPM97_RS22320 ENOG4106KNT transcriptional regulator HPM97_RS22325 ENOG4105CA9 Pyruvate kinase HPM97_RS22330 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HPM97_RS22335 ENOG4105DR5 peptidase HPM97_RS22340 ENOG4105NXV High-affinity zinc uptake system protein HPM97_RS22350 ENOG4105FAV ABC, transporter HPM97_RS22375 ENOG4107S01 Repressor protein MetJ HPM97_RS22385 ENOG4105CDY transcriptional regulatory protein HPM97_RS22390 ENOG4108TIT dATP pyrophosphohydrolase HPM97_RS22400 ENOG4105D3W isochorismatase HPM97_RS22405 ENOG41081XQ Conserved Protein HPM97_RS22410 ENOG4105WJG Glutathione HPM97_RS22425 ENOG4107QY8 reductase HPM97_RS22430 ENOG4105CUW cytochrome C-TYPE protein HPM97_RS22440 ENOG4106ZCM YecM protein HPM97_RS22450 ENOG4105W13 flagellar protein HPM97_RS22455 ENOG4105D7B Flagellar biosynthesis protein flha HPM97_RS22460 ENOG4105D00 flagellar biosynthetic protein flhB HPM97_RS22465 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HPM97_RS22470 ENOG4108VYJ response regulator receiver protein HPM97_RS22480 ENOG4105BZU Histidine kinase HPM97_RS22485 ENOG4105C8Q Methyl-accepting chemotaxis HPM97_RS22490 ENOG4105C8Q Methyl-accepting chemotaxis HPM97_RS22495 ENOG4108V3W Chemotaxis protein, CheW HPM97_RS22500 ENOG4105CBS Chea signal transduction histidine kinase HPM97_RS22505 ENOG4105ER2 Ompa motb domain protein HPM97_RS22510 ENOG4107RD7 Flagellar Motor Protein, MotA HPM97_RS22515 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HPM97_RS22525 ENOG4108VA4 Universal stress protein HPM97_RS22535 ENOG4108K4C ec 3.1.3.12 HPM97_RS22540 ENOG4105CNN ABC, transporter HPM97_RS22545 ENOG4105C2J ABC transporter HPM97_RS22550 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HPM97_RS22555 ENOG4108UEC Ferritin-like protein HPM97_RS22560 ENOG4105N4N Protein of unknown function (DUF2766) HPM97_RS22570 ENOG4105P23 (LipO)protein HPM97_RS22575 ENOG41090A1 ferritin HPM97_RS22580 ENOG4105VVZ metal-binding protein HPM97_RS22585 ENOG4105E0U tyrosine-specific transport protein HPM97_RS22590 ENOG4106RHG Yeca family HPM97_RS22620 ENOG4105WH1 Two component transcriptional regulator luxr family HPM97_RS22630 ENOG4105XVG cytoplasmic protein HPM97_RS22635 ENOG4105VJY transcriptional regulator HPM97_RS22640 ENOG4105CDA abc transporter atp-binding protein HPM97_RS22645 ENOG4105E5Q amino acid AbC transporter HPM97_RS22650 ENOG4105K6H D-cysteine desulfhydrase HPM97_RS22655 ENOG4105EAB amino acid AbC transporter HPM97_RS22660 ENOG4108M9K flagella biosynthesis protein FliZ HPM97_RS22665 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPM97_RS22670 ENOG4105I03 Flagellin HPM97_RS22675 ENOG4105DTS flagellar hook-associated HPM97_RS22680 ENOG4105MQ3 flagellar protein FliS HPM97_RS22685 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HPM97_RS22690 ENOG4105E5K Alpha-amylase HPM97_RS22695 ENOG4108W9D (LipO)protein HPM97_RS22700 ENOG41066VF YeeE YedE family protein HPM97_RS22710 ENOG4108RAV Conserved protein HPM97_RS22715 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HPM97_RS22720 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HPM97_RS22725 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPM97_RS22730 ENOG41090PJ Flagellar assembly protein HPM97_RS22735 ENOG4108JIR Flagellum-specific ATP synthase HPM97_RS22740 ENOG4105GSA Flagellar export protein flij HPM97_RS22745 ENOG4105WF4 Flagellar hook-length control protein HPM97_RS22750 ENOG4107ZI8 flagellar basal body-associated protein flil HPM97_RS22755 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPM97_RS22760 ENOG4105DD5 Flagellar motor switch protein HPM97_RS22765 ENOG4105K0P flagellar biosynthesis protein HPM97_RS22770 ENOG4105CN7 Flagellar biosynthetic protein FliP HPM97_RS22780 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HPM97_RS22785 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HPM97_RS22795 ENOG4105YX3 cellular response to acidity HPM97_RS22810 ENOG4105VNZ cytoplasmic protein HPM97_RS22815 ENOG4105CKW Inner membrane protein yedI HPM97_RS22820 ENOG4105FDR Membrane HPM97_RS22825 ENOG41090BB DNA mismatch endonuclease (vsr) HPM97_RS22830 ENOG4105DVF Cytosine-specific methyltransferase HPM97_RS22835 ENOG4105EST Metal Dependent Phosphohydrolase HPM97_RS22840 ENOG4105Y0K Inner membrane protein YedR HPM97_RS22845 ENOG4105ZIT Porin Gram-negative type HPM97_RS22850 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) HPM97_RS22855 ENOG4107ZY3 Histidine kinase HPM97_RS22860 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPM97_RS22865 ENOG4105VT2 5-hydroxyisourate hydrolase HPM97_RS22880 ENOG4108MEK Metal-binding protein YodA HPM97_RS22885 ENOG4108VKM cytochrome b561 HPM97_RS22895 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HPM97_RS22915 ENOG4105EYM Major Facilitator superfamily HPM97_RS22920 ENOG4105BZ1 (ABC) transporter HPM97_RS22935 ENOG4105C0W non-ribosomal peptide synthetase